Court Opinion

ID: 4407959
Source: CourtListenerOpinion
Date Created: 2019-06-19 04:01:35.441152+00
Date Added: 2024-06-11T14:52:47.055621
License: Public Domain

In the United States Court of Federal Claims
                                     OFFICE OF SPECIAL MASTERS
                                               No. 11-577V
                                           Filed: May 24, 2019
                                             To be Published

*************************
D.G.,                                       *
                                            *
               Petitioner,                  *
                                            *
 v.                                         *      Influenza (“flu”) vaccine; seizures;
                                            *      autoimmune autonomic neuropathy;
SECRETARY OF HEALTH                         *      gastroparesis; POTS; myasthenia
AND HUMAN SERVICES,                         *      gravis; conversion disorder
                                            *
               Respondent.                  *
                                            *
*************************
Lisa A. Roquemore, Rancho Santa Maria, CA, for petitioner.
Justine E. Walters, Washington, DC, for respondent.

MILLMAN, Special Master
                                           DISMISSAL DECISION1
       On September 9, 2011, petitioner filed a petition under the National Childhood Vaccine
Injury Act, 42 U.S.C. § 300aa-10-34 (2012), alleging that influenza (“flu”) vaccine administered
on August 23, 2009 caused her muscle weakness, fatigue, dizziness, excessive sweating
especially after meals, whose onset was 10 days post-vaccination. On September 12, 2009, she
alleged she had seizure and fainting after breakfast. On September 17, 2009, she alleged

1
  Vaccine Rule 18(b) states that all decisions of the special masters will be made available to the public unless they
contain trade secrets or commercial or financial information that is privileged and confidential, or medical or similar
information whose disclosure would constitute a clearly unwarranted invasion of privacy. This means the decision
will be available to anyone with access to the Internet. When such a decision is filed, petitioner has 14 days to
identify and move to redact such information prior to the document’s disclosure. If the special master, upon review,
agrees that the identified material fits within the banned categories listed above, the special master shall redact such
material from public access. On August 16, 2017, petitioner filed a status report in which she informally moved to
change the caption to reflect just her initials “for privacy reasons.” S.R., at 2. On the same date, the undersigned
granted petitioner’s informal motion to redact her name to her initials and ordered the Clerk of Court to change the
case caption, which the Clerk of Court did. This case is already redacted.
vasovagal syncope,2 benign systolic murmur, positive ANA,3 multiple somatic complaints,
anxiety, dystonia, neurocardiogenic syncope,4 and postural orthostatic tachycardia syndrome
(“POTS”).5 Pet. at ¶¶ 9, 12, 13, 15, 15, 19, 20, 23, 25, 28. 31, 34, 38, 41. Petitioner’s affidavit,
dated September 7, 2011, was attached without an exhibit number.
                                         PROCEDURAL HISTORY
         On September 9, 2011, this case was assigned to former Special Master Daria J. Zane.
         On February 21, 2012, petitioner filed a status report regarding record collection in which
petitioner’s original counsel Robert J. Krakow stated that he was having difficulty obtaining
treatment records from Dr. Rashid A. Buttar because of an unpaid bill reflected in Exhibit 56.
S.R., at 5. Mr. Krakow states that Generation Rescue offered to pay for all medical treatment
and expenses for petitioner’s medical treatment by Dr. Buttar, an osteopath. Id. at 6. The
condition for Generation Rescue’s payment of petitioner’s medical treatment and expenses was
petitioner’s agreement to being on video during Dr. Buttar’s treatment of her. Id. Mr. Krakow
states that for reasons Generation Rescue did not explain to petitioner, Generation Rescue
discontinued its involvement with Dr. Buttar’s treatment of petitioner and refused to pay her
medical bills for that treatment. Id.
         On May 9, 2012, petitioner filed as Exhibit 58 an external terabyte hard drive with the
name “DG Copy” consisting of files of videos. Each video is marked by the name of the digital
file or folder as the files appear on the hard drive.
        On July 16, 2012, petitioner’s counsel filed a motion to withdraw. Mot. Petitioner wrote
her counsel on May 30, 2012, stating that “she wished to ‘take over representation of my case’
and instructed counsel to discontinue representation of her before the Court for all purposes.”
Mot., at 1.
       On October 2, 2012, petitioner filed a consented Motion to Substitute Attorney, which
former Special Master Zane granted on October 22, 2012.

2
  Vasovagal syncope is “a transient vascular and neurogenic reaction marked by pallor, nausea, sweating,
bradycardia, and rapid fall in arterial blood pressure which, when below a critical level, results in loss of
consciousness and characteristic electroencephalographic changes. It is most often evoked by emotional stress
associated with fear or pain.” Dorland’s Illustrated Medical Dictionary 1818 (32nd ed. 2012) [hereinafter,
“Dorland’s”].
3
  ANA or antinuclear antibodies are “antibodies directed against nuclear antigens; ones against a variety of different
antigens are almost invariably found in systemic lupus erythematosus and are frequently found in rheumatoid
arthritis, scleroderma (systemic sclerosis), Sjögren syndrome, and mixed connective tissue disease. Antinuclear
antibodies may be detected by immunofluorescent staining. Serologic tests are also used to determine antibody
titers against specific antigens.” Dorland’s at 101.
4
  Neurocardiogenic syncope is “a serious type of vasovagal syncope precipitated by a stimulus that causes either
bradycardia, a decrease in vascular tone, or both at once.” Dorland’s at 1818.
5
  Postural orthostatic tachycardia syndrome (POTS) is “a group of symptoms (not including hypotension) that
sometimes occur when a person assumes an upright position, including tachycardia, tremulousness, lightheadedness,
sweating, and hyperventilation; this is seen more often in women than in men, and the etiology is uncertain.”
Dorland’s at 1844.

                                                          2
          On December 6, 2012, petitioner filed a Statement of Completion.
      On March 19, 2013, respondent filed his Rule 4(c) Report, recommending against
compensation.
        On June 11, 2013, petitioner filed a status report regarding her review of video footage
and attached a list of those videos which she contended were relevant and irrelevant. Videos
included interviews on the television shows “20/20,” “Inside Edition,” “60 Minutes,” “NBC
Washington,” “Fox D.C. News,” and “NBC Charlotte News,” videos of petitioner incapable of
walking forward and then running races, and multiple videos during the week she spent at Dr.
Buttar’s treatment center in North Carolina.
       On July 7, 2013, former Special Master Zane issued a decision awarding interim
attorneys’ fees and costs to petitioner’s former attorney, stating that the special master concluded
a reasonable basis existed only up to the point of petitioner’s former counsel’s withdrawal.
“Whether a reasonable basis existed beyond this point and continues to exist to date cannot be
decided based on the record at present, and this decision should not be construed as making any
such decision.” Int. Fees Dec. at 5 n.7. Former Special Master Zane awarded petitioner’s former
counsel $44,961.65 in fees and costs. Id. at 8. Judgment entered on August 2, 2013.
      On September 4, 2013, this case was reassigned to former Special Master Lisa Hamilton-
Fieldman.
       On October 22, 2013, petitioner filed the expert report of Dr. Lawrence Steinman, a
neurologist. Ex. 65. This was over two years after she filed her petition.
          On April 25, 2014, respondent filed the expert report of Dr. Peter D. Donofrio. Ex. B.
        On May 30, 2014, former Special Master Hamilton-Fieldman issued a decision awarding
petitioner’s interim costs of $2,950.29. Judgment entered on July 1, 2014.
          On August 14, 2014, petitioner filed the first supplemental expert report of Dr. Steinman.
Ex. 92.
        On August 19, 2014, former Special Master Hamilton-Fieldman issued an Order for
petitioner to file a second supplemental report from Dr. Steinman, explaining how demyelination
led to the variety of petitioner’s symptoms.
          On August 28, 2014, petitioner filed Dr. Steinman’s second supplemental report. Ex.
108.
       On January 13, 2015, respondent filed the expert report of Dr. Eric Lancaster, a
neurologist. Ex. H.
          On January 15, 2015, the case was reassigned to the undersigned.
          On February 20, 2015, respondent filed the expert report of Dr. J. Lindsay Whitton. Ex.
Z.
          On June 1, 2015, petitioner filed a third supplemental report of Dr. Steinman. Ex. 118.
                                                  3
        On August 11, 2015, respondent filed a Motion for Issuance of Subpoena to obtain any
and all documentation, video files, audio files, news releases, reporting, or broadcasts, and/or
website postings/updates relating to petitioner posted on Dr. Buttar’s websites. On the same
date, the undersigned granted respondent’s motion.
       On September 4, 2015, respondent filed the first supplemental expert reports of Dr.
Lancaster (Ex. RR) and Dr. Whitton (Ex. SS).
        On October 13, 2015, petitioner filed a supplemental declaration in support of her
petition (Ex. 139). She explains how she became a media star by saying she alerted her family
and friends about her physical problems. Ex. 139, at 4. One of her former colleagues was
working for the county newspaper and asked if he could do an article in his paper explaining her
condition and its being tied to flu vaccine. Petitioner writes she agreed since he was a friend and
struggling to get started in his new job. Petitioner writes:
               After I learned that the flu vaccine was causing my issues, I
               thought I was doing a public service by speaking out as perhaps the
               batch of vaccine I received was tainted. From there the media
               circus began, starting with local stations contacting me to national
               syndicates. However, I remember one of my doctors or
               psychologists recommending later on that I should avoid the media
               as the chaos was probably not helping my symptoms, but likely
               contributing to them.
Id.
       Petitioner continues in her supplemental declaration by saying that she thought her first
attorney Robert Krakow, whom her then-husband hired per Stan Kurtz’s recommendation, was
involved to help her deal with media relations. Id. She continues:
               At this time, I was also contacted by Stan Kurtz from Generation
               Rescue, who is an anti-vaccine advocate. He and his organization
               quickly commandeered my injury to turn it into a poster story for
               their cause against vaccines[.] [I]n exchange they promised to
               “cure” me with the help of Dr. Buttar. Upon the advice of Dr.
               Buttar, I declined Dr. Cintron’s plasmaparesis [sic]
               recommendation and started receiving [Dr. Buttar’s] protocol of
               several bags of IV hydration mixed with his own cocktail of
               vitamins. This began to relieve quite a bit of the dizziness and
               fainting I had when I stood up or ate. Slowly, my speech started to
               improve and I could eat, but limited amounts of food. . . .
Id. at 4-5. Petitioner then goes through the videos respondent’s neurologic expert Dr. Lancaster
saw and about which he comments in his first expert report (Ex. H). Petitioner gives her own
interpretation of them. Id. at 8-25. She mentions giving an interview to channel 5 and stating
she could not walk or talk normally and the only thing she could do was run. Id. at 10. She

                                                 4
states her voice returned when she was running. She told John Henry of Channel 5 that when
she runs, her heart rate would go down to 60, whereas when she walked, her heart rate was in the
130s. Id. at 10.
        She mentions that Dr. Buttar talked about getting thousands of patients after airing on
television petitioner’s treatment with him. Id. at 23. He talked about people paying $500-600
for his drops. Petitioner states she is not sure how the drops work, but they did seem to improve
her muscle weakness, but much faster than her myasthenia drugs do because of the drops’ rapid
absorption through her skin. Id. Petitioner describes getting an EEG with Ms. Preston, whom
she refers to as “Dr.” Preston even though she is a Ph.D., not a medical doctor. Id. at 24.
Petitioner says Dr. Preston determined petitioner was having seizure. Id.
         On January 13, 2016, petitioner filed a fourth supplemental report of Dr. Steinman. Ex.
141.
       On April 26, 2016, respondent filed a CD with Exhibits AAA-JJJ, consisting of the
following: Ex. AAA, “20/20” broadcast, approximately July 25, 2010; Ex. BBB, “Inside Edition
Update,” February 4, 2010; Ex. CCC, “20/20” broadcast followed by Robert Scott Bell show;
Ex. DDD, [D.G.] update, October 29, 2009; Ex. EEE, “NBC Washington,” October 15, 2009;
Ex. FFF, “Fox 5 DC News,” October 15, 2009; Ex. GGG, “Inside Edition,” October 16, 2009;
“Ex. HHH, “Fox 5 DC News,” October 19, 2009; Ex. III, “NBC Charlotte,” November 5, 2009;
and Ex. JJJ, “Fox 5 DC News,” November 19, 2009. 6
       From June 14-17, 2016, the undersigned held a four-day hearing. On the second day of
the hearing, petitioner sank from her chair to the floor in the hearing room, making growling
noises. The undersigned asked petitioner’s expert Dr. Steinman to attend to her while the
undersigned’s law clerk called 911. Petitioner was transported by ambulance to MedStar
Georgetown University Hospital, which necessitated the obtaining of those hospital records and
the subsequent opinions of the experts interpreting those records after the hearing.
      On July 14, 2016, respondent filed the second supplemental expert report of Dr. Whitton.
Ex. YYY.
      Also, on July 14, 2016, petitioner filed the fifth supplemental expert report of Dr.
Steinman. Ex. 181.
        On September 7, 2016, petitioner filed her second supplemental declaration (Ex. 190).
Attached to her declaration is a copy of e-mail she sent to her treater Dr. Joey R. Gee consisting
of her question and his response (Attachment 2): [D.G.] “Given the positive GAD7 antibody

6
  Respondent also relied on the videos respondent identified as Respondent’s Trial Exhibit 58-1 to Respondent’s
Trial Exhibit 58-66, which were specific videos derived from petitioner’s Exhibit 58 (the external terabyte hard
drive). Doc 143. Respondent relied on additional videos identified by dates from October 17, 2009 to October 22,
2009 including nine undated videos. Multiple videos come from Dr. Buttar’s treatment center. Respondent’s expert
Dr. Lancaster identifies the videos upon which he relies as support for his opinion in his first expert report (Ex. H).
Respondent added Respondent’s Trial Exhibit 58-66 to the prior list of Respondent’s Trial Exhibit 58-1 to
Respondent’s Trial Exhibit 58-65 at the hearing, noted in a filing dated June 21, 2016. Doc 147.
7
  GAD or glutamate decarboxylase or glutamic acid decarboxylase is “an enzyme of the lyase class that catalyzes

                                                           5
result, do you think this explains some of the spasms and tremors you saw in the videos online
when you first took me on as a patient.” Petitioner then says that when she tried to go off
gabapentin8 a year previously, a lot of her symptoms returned, necessitating her going back on
gabapentin, and she wondered if the drug were masking her symptoms. Dr. Gee responded, “It
just might…I did think about that. The spasms can be quite extreme. I am dealing with this
same issue now with a new patient and her GAD have been fluctuating between 10 to over 100[;]
she is on IVIG now.”
      On October 14, 2016, petitioner filed the sixth supplemental expert report of Dr.
Steinman. Ex. 191.
      On December 16, 2016, respondent filed the third supplemental expert report of Dr.
Whitton (Ex. ZZZ) and the second supplemental expert report of Dr. Lancaster (Ex. FFFF).
      On May 16, 2017, petitioner filed the seventh supplemental expert report of Dr.
Steinman. Ex. 198.
        On May 17, 2017, petitioner filed her third supplemental declaration (Ex. 205), arguing
that respondent’s neurologic expert Dr. Lancaster was wrong for assuming Dr. Gee told the
treating doctors at MedStar Georgetown University Hospital that petitioner had a “non-organic
(psychogenic)9 gait disorder.” Ex. 205, at 3. She asserts that in the five years she has been
seeing Dr. Gee, he never “even insinuated” that she had an underlying psychogenic illness. Id.
        Also, on May 17, 2017, the undersigned issued an Order to petitioner that she file by June
19, 2017 a statement from Dr. Gee indicating whether he believed petitioner had a high GAD
antibody in 2009 and, if she did, whether the high GAD antibody could have caused some of
petitioner’s spasms and tremors that she manifested in 2009 in her videos. Moreover, the
undersigned asked Dr. Gee to opine whether he thought petitioner had myasthenia gravis in 2009
and, if he did not think she did, then how would a purportedly high GAD antibody be connected
to her spasms and tremors in 2009. Dr. Gee never provided petitioner with answers to the
undersigned’s questions. Therefore, the undersigned never learned if petitioner’s assertions in
her third supplemental declaration (Ex. 205) as to what Dr. Gee told her were accurate.
       On June 19, 2017, petitioner filed the eighth supplemental expert report of Dr. Steinman,
answering the questions the undersigned asked Dr. Gee to answer in her Order of May 17, 2017,
even though the undersigned addressed those questions to Dr. Gee and not to Dr. Steinman. Ex.
206.
        On September 15, 2017, petitioner filed an amended petition, which repeats in detail her
prior allegations. She states flu vaccine caused her the following conditions: (1) autoimmune

the decarboxylation of glutamate to form ƴ-aminobutyrate (GABA). The enzyme is a pyridoxal phosphate protein,
and the reaction occurs within the mitochondria in kidney, and outside the mitochondria in brain. Deficiency of the
brain enzyme may be the cause of convulsions that begin in infancy and are responsive to pyridoxine therapy.”
Dorland’s at 790.
8
  Gabapentin is “an anticonvulsant that is a structural analogue of ƴ-aminobutyric acid (GABA), used as adjunctive
therapy in the treatment of partial seizures; administered orally.” Dorland’s at 753.
9
  Psychogenic means “produced or caused by psychological factors. See also psychosomatic.” Dorland’s at 1549.

                                                         6
autonomic neuropathy/dysautonomia;10 (2) myasthenia gravis11 and in parenthesis states the
following: petitioner admits myasthenia gravis is not her expert Dr. Steinman’s “favorite”
diagnosis; instead it is Dr. Geoffrey L. Sheean’s diagnosis and Dr. Steinman puts a high value on
Dr. Sheean’s opinion; and (3) autoimmunity to GAD. Am. Pet. at ¶ 60.
      On October 30, 2017, petitioner filed the ninth supplemental expert report of Dr.
Steinman. Ex. 208. On the same date, respondent filed the fourth supplemental expert report of
Dr. Whitton (Ex. MMMM) and the third supplemental expert report of Dr. Lancaster (Ex.
QQQQ).
        On February 7, 2018, petitioner filed her post-hearing brief.
        On May 31, 2018, respondent filed his responsive post-hearing brief.
        On July 2, 2018, petitioner filed her reply post-hearing brief.
       Petitioner filed 209 exhibits and respondent filed 80 exhibits, for a total of 289. The
undersigned has read all of them and the entire 1,110-page transcript. The undersigned has
weighed the conflicting opinions of the experts and observed their demeanor at trial. The
undersigned has seriously considered the opinions of the 58 treating/diagnosing doctors and two
psychologists.
        Because the evidence in this case as well as the more persuasive opinions of respondent’s
experts and supporting medical literature show that petitioner did not have an adverse reaction to
flu vaccine, the undersigned DISMISSES this case.
                                                     FACTS
                                           Prevaccination Records
        Petitioner was born on December 23, 1983. She is 35 years old.
       Prior to vaccination, petitioner was generally healthy without significant medical
problems. She had a medical history of bronchitis, nose surgery, bulimia,12 and breast
augmentation surgery. Med. recs. Ex. 2, at 11-12; Ex. 9, at 2-3; Ex. 21, at 1-2; Ex. 22, at 24-26.
        On November 29, 2004, petitioner saw Dr. Michael Rodriguez of Broadlands Family
Practice, complaining of a fungus for the past week or two. Med. recs. Ex. 11, at 33. Petitioner

10
   Dysautonomia is “malfunction of the autonomic nervous system.” Dorland’s at 575.
11
   Myasthenia gravis is “an autoimmune disease of neuromuscular function due to the presence of antibodies to
acetylcholine receptors at the neuromuscular junction; characteristics include muscle fatigue and exhaustion that
fluctuates in severity, without sensory disturbance or atrophy. It may be restricted to one muscle group or become
generalized with severe weakness and sometimes respiratory insufficiency. It may affect any muscle of the body,
but especially those of the eyes, face, lips, tongue, throat, and neck.” Dorland’s at 1214.
12
   Bulimia is “episodic binge eating usually followed by behavior designed to negate the excessive caloric intake,
most commonly purging behaviors such as self-induced vomiting or laxative abuse but sometimes other methods
such as excessive exercise or fasting.” Dorland’s at 259.

                                                         7
weighed 137 pounds. She had a temperature of 100 degrees. Her blood pressure was 130/60.
Id. Dr. Rodriguez diagnosed petitioner with tinea nigra13 (ringworm). Id. at 34.
        On November 16, 2006, petitioner saw Dr. Rodriguez of Broadlands Family Practice, for
tinea nigra. Id. at 32.
       On July 2, 2008, petitioner saw PA-C Deirdre Ellis at Broadlands Family Practice,
needing a health screening for work. Med. recs. Ex. 22, at 29. Her history included rare to
occasional EtOH (ethanol). Id.
        On December 16, 2008, petitioner saw Dr. Huong Thai-Kemprowski, an allergist and
immunologist, for an evaluation of environmental allergies. Id. at 82. Petitioner stated she had
rhinorrhea, nasal congestion, and constant sniffing. She said she had had constant nasal
congestion for the prior 10 years. She has sneezing and itchy eyes in the spring. Her father had
allergic rhinitis. She has post-nasal drip. Id. Physical examination of petitioner’s nose showed
enlarged turbinate with nasal obstruction left greater than right. Id. at 83. Test results showed no
sensitivity to tree pollens, grass pollens, weed pollens, dust mites, cockroach, cat, dog, horse, and
mold spores. Dr. Thai-Kemprowski’s impression was there was no evidence of allergic rhinitis.
Id.
        In March 2009, petitioner became a Washington Redskins Cheerleader Ambassador14 as
a public relations representative for the Washington Redskins. Med. recs. Ex. 31, at 2.
      On April 10, 2009, petitioner and her then-husband saw psychologist Christine M.
Cosgrave for petitioner’s then-husband’s psychotherapy. Med. recs. Ex. 187, at 1, 3.
        On May 14, 2009, petitioner saw Dr. Elizabeth Mann at Broadlands Family Practice,
complaining of headache, sore throat, and chills. Med. recs. Ex. 31, at 27. Dr. Mann diagnosed
petitioner with allergic rhinitis. Id. at 28.
       On May 18, 2009, petitioner saw Dr. Rodriguez at Broadlands Family Practice,
complaining of moderate to severe cough for several days. Id. at 25. She felt tired, achy, and
had trouble sleeping. Id. Dr. Rodriguez diagnosed her with acute bronchitis. Id. at 26.
       On June 22, 2009, petitioner went to Dr. Rodriguez, complaining of moderate to severe
cough for several days. Id. at 23. She felt tired, achy and had trouble sleeping. Id. Dr.
Rodriguez diagnosed petitioner with acute bronchitis. Id. at 24.
                                           Postvaccination Records

13
   Tinea nigra is “a minor fungal infection, caused by Hortaea werneckii, having dark lesions that look like spattered
silver nitrate on the skin of the hands or occasionally other areas.” Dorland’s at 1930.
14
   “Selected during the Redskins Cheerleaders auditions process every April, the Ambassadors’ main focus is
interacting with fans during all Redskins home games at FedExField. While the Redskins Cheerleaders captivate the
90,000+ fans with energetic dance routines, the Ambassadors are in the AAA Ultimate Fan Zone, Touchdown Club
and Suites—and even in the stands—bringing a personal, up-close interaction with fans.” Washington Redskins
Cheerleader Ambassadors, ULTIMATE CHEERLEADERS, https://ultimatecheerleaders.com/tag/ambassadors/ (last
visited Mar. 18, 2019).

                                                          8
       On August 23, 2009, petitioner received flu vaccine at a Safeway Pharmacy in Reston,
Virginia. Med. recs. Ex. 4, at 3.
        On September 12, 2009, petitioner was transported via emergency medical services
(“EMS”) to the emergency department (“ED”) at Inova Loudoun Hospital, complaining of
weakness, overall not feeling well for the last nine days, subjective fevers, body aches,
weakness, and dizziness although she worked full time and ran every day to train for a 5K race.
Med. recs. Ex. 5, at 6, and Ex. 51, at 112. Petitioner reported having bronchitis four to five times
since February 2009 treated with antibiotics, although she still had a productive cough and
fatigue. Id. The assessment was rhabdomyolysis,15 near syncope, recurrent respiratory issues,
elevated liver function test. Med. recs. Ex. 51, at 113. Petitioner had no problem getting out of
bed to a chair and her speech and thoughts were clear. Id. The nursing assessment noted
petitioner was hyperventilating, complaining of fever, syncope, dizziness, nausea, non-
productive cough, pain in her left upper quadrant, shivering, and feeling cold. Her speech was
clear and understandable. Her temperature was normal. Med. recs. Ex. 5, at 15. The onset of
symptoms was sudden. She did not have any associated shortness of breath. She reported that
she “was watching TV and almost passed out and began to shake.” Id. at 9. She reported a
history of lightheadedness, dizziness, weakness, subjective fevers, and body aches over the
previous nine days. Id. at 6, 9. Petitioner said she had a sore throat for several days the prior
week. Id. at 10.
        On physical examination, Dr. Zachary Malachias noted petitioner was well-appearing,
alert and oriented, appeared comfortable, and had a normal pulse and blood pressure, but an
increased respiratory rate. Id. Neurologically, she did not have focal motor deficits, focal
sensory deficits, or nystagmus.16 She had intact cranial nerves and normal speech. She was
oriented, and had normal affect, insight, and concentration. Id. Her EKG was normal. Id. Her
oxygen saturation was normal. Id. at 11. Petitioner was admitted to the hospital. Id. On blood
testing in the ED, petitioner’s mono percentage was high at 10.9. Id. at 12. She tested negative
for both influenza A antigen and influenza B antigen, indicating she did not have the flu. She
tested negative for mono. Id. Her creatine kinase (“CK”)17 tested high at 12,018 U/L when the
normal range is between 19-204. Id. at 13. Her myoglobin18 tested high at 675 ng/mL when the

15
   Rhabdomyolysis is “disintegration or dissolution of muscle, associated with excretion of myoglobin in the urine.”
Dorland’s at 1637. Myoglobin is “the oxygen-transporting pigment of muscle [which] combines with oxygen
released by erythrocytes, stores it, and transports it to the mitochondria of muscle cells, where it generates energy by
combustion of glucose to carbon dioxide and water.” Id. at 1223.
16
   Nystagmus is “an involuntary, rapid, rhythmic movement of the eyeball, which may be horizontal, vertical,
rotatory, or mixed.” Dorland’s at 1307.
17
   Creatine kinase (CK) is “an Mg2+-activated enzyme of the transferase class that catalyzes the phosphorylation of
creatine by ATP to form phosphocreatine. The reaction effectively stores the energy of ATP as phosphocreatine in
muscle and brain tissue and holds the muscle concentration of ATP nearly constant during the initiation of exercise.”
Dorland’s at 429. ATP is adenosine triphosphate. Id. at 173. Adenosine triphosphate is “a nucleotide, the 5’-
triphosphate of adenosine, involved in energy metabolism and required for RNA synthesis; it occurs in all cells and
is used to store energy in the form of high-energy phosphate bonds. The free energy derived from hydrolysis of
ATP is used to drive metabolic reactions including the synthesis of nucleic acids and proteins, to move molecules
against concentration gradients (active transport), and to produce mechanical motion (contraction of microfibrils and
microtubules).” Id. at 30.
18
   Myoglobin (Mb) is “the oxygen-transporting pigment of muscle, a type of hemoprotein resembling a single

                                                           9
normal range is 0-62. Id. at 14. Her CKMB19 mass tested high at 7.49 ng/mL when the normal
range is 0.00-3.38. Id.
        As an inpatient, petitioner reported during a History and Physical that she had bronchitis
four to five times since February 2009 and was treated with antibiotics, although she still had a
productive cough and fatigue. Id. at 6. Despite her symptoms, petitioner was working full-time
and running every morning to train for a 5K race. Id. Petitioner had a history of eating disorder
years ago. Id. Her history also includes turbinate20 reduction, rhinoplasty,21 and breast
augmentation. She reported a questionable blood transfusion during her breast augmentation
surgery. Id. Her white count was 10.9. Id. She had no acute findings on chest x-ray. Id. She
was negative for flu. Id. at 7.
        On physical examination, petitioner was alert and oriented. Id. She was not in acute
distress. The diagnosis was rhabdomyolysis, leukocytosis,22 and near syncope. Petitioner did
not have any gross neurologic deficits. She was out of bed to a chair without difficulty. Her
speech and thoughts were clear. Petitioner had recurrent respiratory issues of an ongoing cough
and fatigue. Id. She had an increased respiratory rate, but she was otherwise afebrile with no
abnormalities. Id. at 10. Petitioner was diagnosed with rhabdomyolysis, leukocytosis, near
syncope, recurrent respiratory issues, elevated liver function tests, and a heart murmur. Id. at 7.
She was admitted to the hospital for hydration with IV fluids. Id. at 7. The results of her chest
x-ray on September 12, 2009 and brain CT scan were normal. Id. at 25, 26. Her chest x-ray on
September 13, 2009 showed small non-specific hypodensities in her thyroid. Id. at 28. Her EKG
on September 12, 2009 was normal. Id. at 31.
       Petitioner was discharged on September 14, 2009. Med. recs. Ex. 5, at 2. Dr. Brian A.
Hazen wrote the discharge summary stating serial laboratory tests included a CPK which was
12,018 on September 12, 2009, but 6,546 on September 13, 2009; an AST23 which was 366 on
September 12th, but 167 on September 14th; and an ALT24 which was 102 on September 12th, but
80 on September 14th. Id. Dr. Hazen stated these test results were probably reflective of muscle
damage and not a hepatic process. Petitioner’s long-term goal was long-distance running. Dr.
Hazen told her to get one more test of her CPK and liver function before ensuring she had
completely resolved from the muscle damage of rhabdomyolysis. In the meantime, he said it

subunit of hemoglobin, composed of one globin polypeptide chain and one heme group (containing one iron atom);
it combines with oxygen released by erythrocytes, stores it, and transports it to the mitochondria of muscle cells,
where it generates energy by combustion of glucose to carbon dioxide and water.” Dorland’s at 1223.
19
   CKMB is “CK2 (MB) … primarily in cardiac muscle.” Dorland’s at 429.
20
   Turbinate is “any of the nasal conchae.” Dorland’s at 1991.
21
   Rhinoplasty is “a plastic surgical operation on the nose, either reconstructive, restorative, or cosmetic.” Dorland’s
at 1640.
22
   Leukocytosis is “a transient increase in the number of leukocytes in the blood; seen normally with strenuous
exercise and pathologically accompanying hemorrhage, fever, infection, or inflammation.” Dorland’s at 1028.
23
   AST is aspartate transaminase. Dorland’s at 167. “The serum level of aspartate transaminase (SGOT) and that of
other transaminases are frequently elevated in a variety of disorders causing tissue damage.”
24
   ALT is alanine transaminase. Dorland’s at 54. Alanine transaminase is “an enzyme found in serum and body
tissues, especially in the liver. Serum enzyme activity (SGPT) is greatly increased in liver disease and also elevated
in infectious mononucleosis.” Id. at 43.

                                                          10
was all right for her to do very light, brief aerobic exercise, to stay hydrated, not to do anaerobic
exercise, and to avoid excessive heat. Id. Petitioner’s diagnosis was mild rhabdomyolysis. Id.
        On September 17, 2009, petitioner returned to the ED at Inova Loudoun Hospital,
complaining of sudden lightheadedness, blackout, and shortness of breath, noting immediate
restoration of normal mental status. Med. recs. Ex. 51, at 13. Dr. Pranav Vermani did a physical
examination, noting weakness bilaterally in the upper extremities and profound weakness
bilaterally in the lower extremities. Id. at 14. On the same day, during a consultation with Dr.
Sarbjot S. Dulai, a neurologist, petitioner reported that she had subjective fevers, chills, body
aches, generalized fatigue, weakness, and intermittent lightheadedness. Id. at 21. She had
shortness of breath and tingling in her feet and hands when she was hyperventilating. Id.
Petitioner continued to train for a 5K race. Although she was admitted to Inova Loudoun
Hospital on September 12, 2009 and discharged on September 14, 2009, she continued to have
subjective chills and fevers, generalized body aches, and intermittent lightheadedness. She
claimed multiple brief episodes of passing out which occurred only when she was sitting or
standing. She thought her shortness of breath was related to hyperventilation, when she would
get some tingling in her feet and hands. Petitioner received intravenous hydration in the
emergency room. She reported some headaches without visual changes or problems with
speech, swallowing, or balance. Id. Dr. Dulai noted petitioner had very minimal weakness
proximally in the lower extremities. Id. at 4, 23. Petitioner’s neurologic examination was
otherwise unremarkable. Id. at 23. Dr. Dulai’s impression was that petitioner’s symptoms were
due to a continuation of her viral syndrome and possibly a component of dehydration. Id.
         On September 17, 2009, petitioner’s AST was high at 60 U/L when the normal range is
5-40. Med. recs. Ex. 6, at 6. Her ALT was also high on September 17, 2009 at 61 U/L when the
normal range is 7-56. Id. On September 17, 2009, petitioner’s ANA was 1:80 when normal is
less than 1:40. Med. recs. Ex. 22, at 76. On September 18, 2009, petitioner’s AST returned to
normal at 38 and her ALT returned to normal at 48. Med. rec. Ex. 6, at 6. On September 17,
2009, petitioner’s CK was elevated at 485 U/L when the normal range is 19-204. Id. at 7. It was
still elevated, but less so, on September 18, 2009 when the CK measured 236 U/L. Id. On
September 17, 2009, petitioner’s C-reactive protein was negative. Id. at 17.
       On September 17, 2009, petitioner had a brain MRI with and without contrast. Id. at 37,
and Ex. 51, at 48. Dr. Ho-Song Lee wrote the brain MRI was normal. There was no mass,
hemorrhage, or extra-axial fluid collection. The gray matter, intracranial vessels and
postcontrast exam were normal. Petitioner had mild left maxillary sinus membrane thickening.
Id.
        On September 18, 2009, petitioner had a consultation with Dr. Jeffrey S. Luy, a
cardiologist, who observed normal muscle strength and tone on physical exam. She also had
normal and appropriate affect. Med. recs. Ex. 51, at 25; Ex. 6, at 1-4; Ex. 22, at 58-59. Dr.
Luy’s impression was that petitioner’s syncope was “probably vasovagal due to some relative
element of dehydration,” prior rhabdomyolysis which had improved, and benign systolic heart
murmur. Med. recs. Ex. 51, at 25. Dr. Luy recommended discharge with fluid, Tylenol, and
rest. Id. On the same day, petitioner was discharged with a diagnosis of “syncope, likely

                                                  11
vasovagal, history of recent rhabdomyolysis, underlying etiology not clear, possible viral illness
with complaint of still being tired and fatigued” and instructions to follow up with her primary
care physician (“PCP”). Id. at 4-5 and med. recs. Ex. 22, at 48.
        On September 21, 2009, petitioner visited her primary care physician (“PCP”) Dr.
Michael Rodriguez at Broadlands Family Practice with concerns of multiple episodes of near
syncope over the past couple of weeks. Med. recs. Ex. 22, at 19. She said that she would feel
dizzy, nauseated, and as if she were going to pass out. Id. She asked Dr. Rodriguez to review
her ED records and tests because she was convinced that her symptoms were due to Lyme
disease even though a Lyme test was negative. Id. On physical examination, Dr. Rodriguez
observed normal joints and muscles. Id. at 20. Dr. Rodriguez referred petitioner to an infectious
diseases specialist, Dr. Sarfraz A. Choudhary, and a rheumatologist, Dr. Alexia Gospodinoff. Id.
         On September 22, 2009, petitioner visited Dr. Choudhary with complaints of headache,
neck pain, multiple joint pains, and pseudoseizures. Id. at 56. On physical examination, Dr.
Choudhary found nothing remarkable. Id. Dr. Choudhary stated the possibilities included
“psychological as [petitioner] had a history of bulimia, tick borne illness like Lyme disease, and
viral illnesses like West Nile.” Id. at 57. He ordered a spinal tap with Inova Loudoun Hospital
to rule out any neurological etiology. Id. Dr. Choudhary also recommended counseling and
reassurance, discussed different infection control precautions, and had petitioner follow up with
her neurologist and cardiologist. Id. A lumbar puncture was performed on September 24, 2009
and the evaluation of lupus was negative. Med. recs. Ex. 7 at 1 and Ex. 44, at 16, 29.
Petitioner’s lumbar puncture showed a normal cerebrospinal fluid (“CSF”) of 24 mg/dL when
the normal range is 15-60. Med. recs. Ex. 7, at 2.
        On September 26, 2009, petitioner went to Inova Fairfax Hospital ED, complaining of
three days of unsteady gait, difficulty with speech, syncope when standing up, shakiness,
constant fatigue, an achy neck, headache, and difficulty sleeping. Med. recs. Ex. 44, at 136.
Petitioner told Dr. Scott Weir that she was recently discharged from Loudon Hospital on
September 21, 2009 for the same symptoms and that she received flu vaccine three days before
her symptoms began. Id. Petitioner arrived via stretcher since she was unable to ambulate. Id.
at 137. Petitioner’s speech was clear and understandable. Her bilateral hand grasp was weak
and toes were progressing upward. Petitioner reported “it feels like numb spots in my mind.” Id.
Petitioner’s family reported petitioner seemed confused at times and sometimes could not finish
her sentences. Id. Her C-reactive protein was normal. Id. at 142. Petitioner said the onset of
symptoms was gradual and occurred on September 3, 2009, starting with a fever and headache.
She developed syncopal episodes after meals, difficulty speaking and concentrating, tremors in
her neck, head, and arms, weakness in her legs, and a wide-based and unsteady gait. She said
she received flu vaccine on August 30, 2009 (the wrong date; she received flu vaccine on August
23, 2009). She was admitted to Loudoun Hospital for a cardiac syncopal workup and discharged
on September 21, 2009 with no definitive diagnosis. Petitioner stated she developed intermittent
paresthesia25 in her legs and arms. She developed seizure-like episodes two days previously with

25
  Paresthesia is “an abnormal touch sensation, such as burning, prickling, or formication, often in the absence of an
external stimulus.” Dorland’s at 1383.

                                                         12
jerking of her arms and legs, but no postictal period or incontinence. Petitioner states she knew
what was happening but could not stop her muscles. She denied slurred speech and stated she
has difficulty concentrating and difficulty getting words out. Id. Petitioner reported chills,
fatigue, weakness, vision changes, seeing visual spots, syncope, nausea, arthralgias, myalgias,
and joint stiffness. Id.
        Physical examination showed petitioner was ill-appearing and uncomfortable. Id. at 143.
The range of movement of her neck was within normal but difficult due to tremulous movements
and stiff motions. She had a tremulous head. Her extremities had 4/5 strength. She had
dysmetria26 on cerebellar examination. Petitioner was admitted to the hospital for neurologic
examination. Id.
        On admission, petitioner complained of a four-day history of worsening and bilateral
lower and upper extremity weakness, difficulty ambulating, and generalized tremors with
multiple vague somatic complaints. Med. recs. Ex. 9, at 1-2; Ex. 44, at 1 (complaining of
syncope, low blood pressure, with an admitting diagnosis of other malaise and fatigue); Ex. 22,
at 50. She complained of having “sweating” in the central core area and mid-epigastric pain that
stopped beneath the sternum. Med. recs. Ex. 44, at 55. She was discharged on September 29,
2009 with a principal diagnosis of abnormal involuntary movement not elsewhere classified
(“NEC”), and secondary diagnoses of lack of coordination, other malaise and fatigue, conversion
disorder,27 obstructive sleep apnea, and stuttering. Med. recs. Ex. 44, at 8.
         Dr. Mohammed A. Mannan was petitioner’s attending physician. Med. recs. Ex. 9, at 1.
Petitioner told Dr. Mannan that she had been in excellent health until around August 30, 2009
(which would be one week after she received flu vaccine). Id. She said within a few days after
getting a flu vaccination, she had a flu-like illness with upper respiratory symptoms,
bronchorrhea,28 sore throat, mild nonproductive cough, fevers, chills, and diffuse myalgias. She
had some lightheadedness, dizziness, and syncopal episodes and presented to Inova Loudon
Hospital. (She went to Inova Loudon Hospital on September 12, 2009.) Id. Dr. Mannan notes
in petitioner’s records that petitioner had a positive ANA “which was only 1:80.” Id.

26
   Dysmetria is “a condition in which there is improper estimation of distance in muscular acts, with disturbance of
the power to control the range of muscular movement, often resulting in overreaching.” Dorland’s at 578.
27
   Conversion disorder is “a mental disorder characterized by conversion symptoms (loss or alteration of voluntary
motor or sensory functioning suggesting physical illness, such as seizures, paralysis, dyskinesia, anesthesia,
blindness, or aphonia) having no demonstrable physiological basis and whose psychological basis is suggested by
(1) exacerbation of symptoms at times of psychological stress, (2) relief from tension or inner conflicts (primary
gains) provided by the symptoms, or (3) secondary gains (support, attention, avoidance of unpleasant
responsibilities) provided by the symptoms. Many patients exhibit “la belle indifference,” a lack of concern about
the impairment caused by the symptoms; histrionic personality traits are also common. Symptoms are neither
intentionally produced nor feigned, and are not limited to pain or sexual dysfunction.” Dorland’s at 549.
Dyskinesia is “distortion or impairment of voluntary movement, as in tic, spasm, or myoclonus.” Id. at 578.
Myoclonus is “shocklike contractions of a portion of a muscle, an entire muscle, or a group of muscles, restricted to
one area of the body or appearing synchronously or asynchronously in several areas.” Id. at 1222. Aphonia is loss
of voice, mutism. Id. at 115.
28
   Bronchorrhea is “excessive discharge of mucus from the bronchi.” Dorland’s at 253.

                                                         13
         Petitioner complained that she had progressive deterioration in the prior four days and
some new symptoms, including symmetric lower greater than upper extremity weakness and
difficulty ambulating, as if her legs were going to buckle due to weakness. She was much more
fatigued and very easily winded with minimal exertion. However, she denied any shortness of
breath at rest, but stated she got very exhausted and short of breath with any minimal exertion.
She reported difficulty sleeping. She stated she had onset of worsening uncontrollable tremors at
times that became worse with effort or exertion. She had intermittent headaches, but no vision
changes. She stated that, at times, she had trouble concentrating and had stuttering speech, but
not specific slurring. She denied the following: difficulty swallowing, chest pain, recent cough,
palpitations, nausea, vomiting, abdominal pain, diarrhea, constipation, urinary changes, calf pain,
swelling, orthopnea, or PND (paroxysmal nocturnal dyspnea29). She described occasional
shooting tingling pains in her lower extremities more than in her upper extremities which was
symmetric. She stated her sensation was intact. She reported intermittent, mainly frontal but
occasionally diffuse, headaches, giving a vague description of occasionally feeling cold spots in
the back of her head. She reported some fainting episodes and occasional lightheadedness which
was somewhat worse when she was upright. She described recent fevers as occasional hot
flashes but did not measure them. She said she received a flu vaccine two to three years ago
without problems. Id. at 2. Her past medical history included chronic bronchitis, bulimia,
obstructive sleep apnea with turbinate reduction around 2008, rhinoplasty, breast augmentation,
intestinal surgery in early childhood, and oral and genital herpes. Id. at 2-3. A chest x-ray done
on September 26, 2009 because petitioner complained of shortness of breath was stable. Dr.
Elise Berman noted petitioner had degenerative change to her right AC (acromioclavicular) joint.
Id. at 7.
        On physical examination, petitioner’s blood pressure was 110/60 and her pulse 70. Id. at
3. She was alert and oriented, well-nourished, somewhat anxious, and generally fatigued, but
generally comfortable. She was very easily fatigued with minimal activity. Id. She did not have
a heart murmur. Id. at 4. Her C3 and C4 complement levels were normal at 85 and 15
respectively.
         Dr. Mannan’s impression was multiple somatic complaints following flu vaccination
initially with flu-like illness with myalgia, rhabdomyolysis, and mild transaminitis (high level of
enzymes), all of which resolved. She had recurrent near syncope and syncope. Id. Petitioner
did not lose her distal deep tendon reflexes. Conversely, she complained of generalized tremors
and possible hyperreflexia, more so in the upper extremities and worse with effort. Dr. Mannan
wrote that “Etiology regarding above constellation of symptoms is not entirely clear at present.”
Id.
       On September 27, 2009, Dr. Jonathan Bresner, a neurologist, saw petitioner because of
abnormal movements. Med. recs. Ex. 44, at 29. Petitioner said that on September 23, 2009, she
had shooting pains in various parts of her body and sensory changes in her head. She felt as
though her whole body was hot although her hands and feet were cold. She described seeing
white spots in her vision and had intermittent headaches. She had lab work done and the only

29
     Dyspnea is “breathlessness or shortness of breath; difficult or labored respiration.” Dorland’s at 582.

                                                            14
abnormality was an ANA of 1:80. Petitioner’s lumbar puncture was normal. Id. A family friend
who is a physician was concerned petitioner had GBS because of her difficulty breathing, which
is why she returned to the ED. Id. at 29-30. She had a history of bronchitis five times in the last
year and going to the ED for severe abdominal pain. Id. at 30. On physical examination,
petitioner had fluent speech, but also stuttering and halting speech. She was alert, oriented, and
anxious. Her strength was 5/5 throughout. Her tone was alternating and uncoordinated with
tremors, contractions, dystonic30 posturing, and myoclonic jerks. She had spastic jerking
movements of the limbs and at times dystonic posturing as well. Her reflexes were 1 to 2+. She
was able to walk unassisted, but had jerking movements of her entire body while she was
walking. Id.
       Petitioner’s lab results were normal for CK, C-reactive protein, and erythrocyte
sedimentation rate. Id. at 31. The protein in her CSF was 24. Dr. Bresner’s impression was
multiple complaints progressing over the last month as well as progressive tremulousness and
abnormal body movements for the prior several days. Dr. Bresner states:
                    The observed movements are extremely peculiar and not easily
                    described from a neurological standpoint. It is also odd that the
                    patient’s symptoms resolved for a long enough period each
                    morning for her to apply makeup but then return so forcefully that
                    she is unable to speak or move her limbs in any sort of coordinated
                    motion. The patient is able to walk despite her inability to control
                    her limbs . . . . I am reassured that her neurological exam is
                    otherwise normal and had an extensive workup including
                    laboratory CSF and reportedly a brain MRI are also unremarkable,
                    excluding a borderline elevated ANA. … I was originally asked to
                    assess the patient for Guillain-Barre syndrome. There is [sic]
                    currently no signs or symptoms on her exam to suggest this
                    diagnosis. A psychogenic etiology to the patient’s symptoms
                    remains a consideration. The patient might benefit from
                    psychological counseling or psychiatric evaluation. . . .
Id. at 31-32.
        On September 28, 2009, petitioner had a psychiatric consultation on a question of
conversion disorder with Dr. Paul M. Dellemonache. Med. recs. Ex. 21, at 1-6, and Ex. 44, at
33-38. Petitioner reported that she had a history of bulimic and self-induced vomiting behavior
during her teens “to control something since my father controlled me.” Med. recs. Ex. 21, at 2.
Neurology had seen petitioner and did not feel her signs and symptoms were consistent with a
clear neurologic etiology and questioned a psychogenic element. Id. at 1. The only stressor
petitioner could mention within the past year was her younger sister’s suicide attempt. Id.
Petitioner felt her sister did that to get attention as she had apparently done before. Petitioner
stopped speaking with her sister who had since moved out of petitioner’s house and back in with

30
     Dystonia is “dyskinetic movements due to disordered tonicity of muscle.” Dorland’s at 582.

                                                          15
petitioner’s father. Petitioner reported her other siblings agree with her regarding her sister, but
denied that this caused any difficult family strife. Petitioner did not speak to her mother after her
parents’ separation when she was 18 years old. Id. Petitioner thought her mother was jealous of
petitioner’s relationship with her father. Id. at 3. She was not distressed when her parents
separated because she felt her father could do better. Petitioner moved out of the house when she
was 18 to her own house which she then flipped and moved into a bigger house but lost its equity
when the housing market declined. She went straight to work at AOL after high school. In order
to get onto the Washington Redskins cheerleading team, she had breast augmentation which she
felt was a necessity to get onto the team. She practices once or twice a month and enjoys it. She
also enjoys marathon running. Id. Petitioner noted that her illness had brought her then-husband
and her “even closer together.” Id. at 5.
        Petitioner said she had bronchitis several times over the prior year and thought her
symptoms might be due to Lyme disease because she had several coworkers and friends who
themselves or their family members had Lyme disease with similar presentations and she had
many tick bites on her legs in the past from running outside. Id. at 2. She also mentioned that
she had a flu vaccination at the end of August which might or might not be related to her
symptoms. Id. Dr. Dellemonache noted that conversion disorder is a “diagnosis of exclusion,”
which could not be conclusively diagnosed until all other workups were exhaustive and
continued to be negative. Id. A lupus anticoagulant evaluation done on September 28, 2009
resulted in no detection. Med. recs. Ex. 8, at 6, 9. Testing for Epstein-Barr virus antibody and
IgG was positive, but IgM was negative. Id. at 10. Cytomegalovirus was not detected. Id. at 16.
        On September 28, 2009, petitioner and her then-husband met with a social worker
Michelle Ougheltree. Med. recs. Ex. 44, at 57. Petitioner still had a significant stutter.
Petitioner was assisted in walking that morning by two persons because her knees buckled and
currently her knees and hips hurt. Petitioner was interested in outpatient therapy. Petitioner’s
then-husband requested SW Ougheltree complete a short-term disability form as petitioner’s sick
leave had run out. The social worker would give the form to petitioner’s PCP. Id.
       On September 29, 2009, petitioner was discharged. Dr. Mannan diagnosed her with
“multiple somatic complaints and progressive but fluctuating neurologic deficits (including
abnormal movements/tremors and speech) of unclear etiology, not fitting any particular pattern.
Possible psychogenic etiology. No evidence of GBS.” Id. at 13. He also said that petitioner’s
orthostatic hypotension was likely due to volume depletion and it improved with intravenous
hydration. Dr. Mannan writes that at the time of petitioner’s presentation, she had “very odd
neurological symptoms with difficulty walking and tremors during evaluation of strength.” Id.
However, petitioner’s reflexes were normal, and she did not have any focal findings. Id. Dr.
Bresner in the ED suspected petitioner’s neurological symptoms were not consistent with GBS
and there could be a psychogenic component to her symptoms. Id. at 13-14.
       In his discharge summary, Dr. Mannan drew attention to the fact that petitioner “was
unable to hold a cup of water in her hand without spilling; however, she was able to fully put
makeup on in the morning during hospitalization, including eyeliner, without complication until
confronted by the nursing staff, after which she no long could do this task.” Id. at 14. All of

                                                 16
petitioner’s lab tests, including Lyme disease, repeat ANA, antiphospholipid antibody panel,
West Nile, and H1 N1, were negative. Id. Dr. Mannan discussed with petitioner’s then-husband
putting petitioner on doxycycline even though multiple tests for Lyme disease were negative.
Her then-husband said petitioner had been very concerned about possible Lyme disease after
researching it on the internet and he felt petitioner would be greatly reassured by empiric
treatment for it. Dr. Mannan gave petitioner a one-week course of doxycycline upon discharge.
In addition, petitioner was treated with IV hydration to help with orthostatic and volume
depletion during this hospitalization. Id. Dr. Mannan spoke with petitioner’s PCP Dr. Rodriguez
who also did not see any clear evidence of obvious organic etiology, and seemed concerned
about a psychogenic etiology, and agreed with a psychiatric evaluation. Id. Petitioner requested
a note for short-term disability but Dr. Mannan suggested she follow up with Dr. Rodriguez
because there was no clear diagnosis. Id. Lab results showed a negative C-reactive protein and a
sedimentation rate of 19. Her cortisol at 10.7 was normal as was her B-12. ANA was detected
with a ratio of 1:80. Lyme antibodies were negative. Med. recs. Ex. 22, at 49.
        On October 2, 2009, petitioner saw Dr. Garry Ho at Broadlands Family Practice, for a
consultation and to review her recent medical problems. Med. recs. Ex. 22, at 15-17. She
discussed multiple sclerosis (“MS”) with Dr. Ho. Id. at 15. Petitioner reported that she woke up
on September 24, 2009 with trouble walking “like I had MS.” Id. She also reported that she
developed dysarthria and stuttering when she tried to talk out loud on September 26, 2009. Id.
At that time, petitioner was in the process of setting up an admission to Johns Hopkins Hospital’s
neuromuscular neurology service. Id. On physical examination, Dr. Ho found petitioner had a
broad-based, spastic, stamping and waddling gait, and dysarthric and stuttering speech. Id. at 16-
17.
        On October 2, 2009, petitioner went to Johns Hopkins Medicine ED and spoke to Dr.
Julius C. Pham. Med. recs. Ex. 55, at 24. Johns Hopkins was to evaluate whether petitioner had
GBS since she reported lower leg weakness that progressed to her upper legs, increased
difficulty speaking and walking, and shortness of breath. Id. She had uncontrollable bobbing of
her head when speaking or making intentional movements. She also described electric-like
shooting pains starting in her legs and moving around her body. She also had symptoms of
dysphonia that whispering or singing in a high-pitched voice relieved. She had difficulty using
her lower limbs for prolonged periods of time because either they gave out or she had
uncontrollable movements in them. Id. Petitioner complained of a headache at the base of her
neck which was constant and dull. Id. When it went away, she had diffuse, cool spots all around
or she developed a headache behind her right eye and again had cool sensations. Id. at 24-25.
Petitioner said she had episodes of uncontrollable blinking that she was unaware of and
photophobia. Id. at 25. She had mild congestion and intermittent tinnitus in her left ear that
woke her. She had dysgeusia.31 Petitioner had inappropriate episodes of uncontrollable laughter.
She had autonomic dysfunction with hot flushing at the core and cool extremities. She had
syncopal episodes associated with eating, and loss of consciousness without incontinence or
tongue biting after she had bobbing of her head. Her sleep cycle was off. She had increased

31
     Dysgeusia is parageusia. Parageusia is “a bad taste in the mouth.” Dorland’s at 577, 1375.

                                                           17
appetite and a recent two-pound weight loss. Warm water worsened her symptoms, particularly
at her knees. Petitioner told Dr. Pham she received flu vaccine on August 30, 2009 (not the true
date of August 23, 2009). She was taking doxycycline and prednisone.32 Id.
        On physical examination, petitioner did not have nystagmus. Id. Her lower extremities
were cool to the touch. Id. at 26. On motor examination, petitioner had an abnormal, ataxic,
waddling/wide stance. Her strength was 4/5 in the upper and lower extremities. Her right upper
extremities were weaker, but her grip was equal. Petitioner tapped her foot and her head bobbed.
Dr. Pham’s final assessment was that petitioner presented with multiple neurologic findings both
central and peripheral in nature. The final diagnosis was weakness. Dr. Pham wrote petitioner
had a complex problem, which was likely neurological, but for which she had not received a
diagnosis even though several outside medical facilities and neurologists had evaluated her.
About one month ago, she was normal. Since then, she developed lower extremity weakness,
paresthesia, and some dysphonia. The differential diagnosis included GBS, MS, Lyme, and
myasthenia gravis. Id. Petitioner awaited admission to neurology for unexplained ascending
weakness and head bobbing. Id.
        A nursing assessment dated October 2, 2009 notes that petitioner was brought to a room
by wheelchair with ED staff. Id. at 27. Petitioner told RN Michelle E. Charron that she had pain
in both ears when she tried to speak. Petitioner said she had difficulty breathing “like I can’t get
enough oxygen.” Id. She said she had nausea after eating and weight loss despite increased food
intake. She had 5/5 muscle strength throughout. She had severely stuttering speech which began
one week previously. She reported progressive weakness in her lower extremities moving up her
legs. Id. RN Pia L. Bolano did a reassessment, during which petitioner denied shortness of
breath, and denied nausea, vomiting, diarrhea or abdominal pain. Id. RN Czereyna C. Pearl
similarly wrote petitioner denied shortness of breath, nausea, vomiting, diarrhea or abdominal
pain. Id. at 28. RN Pearl noted petitioner’s positive stuttering. Id. at 28. A chest x-ray done on
October 2, 2009 was normal. Id. at 33. On October 2, 2009, petitioner had an MRI of her
lumbar spine which did not show abnormal enhancement within the cervical, thoracic, or lumbar
spinal cord or cauda equina. Id. at 18. She had mild degenerative changes including a T7-T8
disc bulge and annular tears in the L4-L5 and L5-S1 discs. Id.
        On October 3, 2009, petitioner was admitted to Johns Hopkins Hospital. Med. recs. Ex.
2, at 11. Dr. Anjajl Sharrief took a history that petitioner received flu vaccine on August 30,
2009 (not the true date of August 23, 2009). Three days afterward, she woke with a sore throat
and congestion, progressing to fever and fatigue. She then had severe fatigue and muscle aches
but continued to work. She came to the emergency department on September 12, 2009 with
generalized weakness and lightheadedness. On the day she presented, she reportedly had
generalized convulsions and an episode of syncope. Her CK was 12,000 on presentation with
MB of 7.5. Myoglobin was 75. Troponin was negative. AST and ALT were elevated at 366
and 102 respectively. Her white blood cell count was 10.6 on admission. This was thought to be
secondary to a viral illness. CK and liver function tests came down with IV fluid hydration. She

32
  Prednisone is “a synthetic glucocorticoid derived from cortisone, administered orally as an anti-inflammatory and
immunosuppressant in a wide variety of disorders.” Dorland’s at 1509.

                                                        18
was admitted from September 12 to 14, 2009 and discharged home. She went back to work on
September 17, 2009 and began feeling weak with nausea and fainting at work. She began
trembling uncontrollably and was readmitted to the hospital. She was discharged the following
day.
        Since her lethargy continued, she saw her PCP on September 21, 2009 who said
petitioner’s ANA was positive at 1:80 and that she had systemic lupus erythematosus (“SLE”).33
Petitioner began having reproducible chest pain and was referred to an infectious disease
specialist and a rheumatologist. When she saw the infectious disease specialist on September 22,
2019, she fainted with convulsions. The doctor had a lumbar puncture performed. Petitioner
began having difficulty ambulating with knees buckling and continued nausea, chills, sweats,
and lightheadedness. She described that at this point she began having vivid dreams and
difficulty sleeping. Id. Petitioner also began having headaches which she told Dr. Sharrief felt
like cold spots in the back of her head. She returned to the hospital on September 27, 2009 with
unsteadiness and difficulty speaking. She described it as pain in her face and neck when she
spoke. She sounded as if she were stuttering. She could talk normally if she whispered. She
began to have symptoms in her toes which petitioner described as their moving erratically and
misfiring. Several specialists whom she saw could not determine the etiology of her symptoms.
She began taking doxycycline for possibly Lyme disease. She also started taking
methylprednisolone34 Dosepak for chest pain which her PCP prescribed. Petitioner’s symptoms
persisted and progressed to intermittent uncontrollable blinking, difficulty focusing, pain in her
neck muscles, uncontrollable shaking, cold feelings in her feet, and sharp pain in her legs. She
was referred to Johns Hopkins ED. Id.
        Petitioner’s history was rhinoplasty, breast augmentation, and oral and genital herpes. Id.
at 12. She has a half-sister who had an autoimmune disorder at age four. Her cousin has
Grave’s disease and now breast cancer. Her maternal great aunt has multiple sclerosis. Her
mother’s father’s mother had fibromyalgia. Her maternal grandmother had breast cancer. Her
maternal grandfather had lung cancer. Her father has a benign brain tumor. Petitioner said she
has possible tick bites from a 5K run in August 2009. Id.
         On physical examination, Dr. Sharrief noted that petitioner was well-appearing, sitting up
in a stretcher in no apparent distress. Her face was “very well made up.” Id. Her heart rate was
77, and blood pressure 111/63. Neurologically, petitioner was spontaneously alert and oriented.
She was able to give a full history which was limited only by her inability to speak properly. She
had good attention and a normal fund of knowledge. She registered 4 out of 4 items and recalled
4 out of 4 after five minutes. Id. Petitioner spoke in a broken voice taking deep gasps of air
between words. Id. at 13. Her speaking appeared labored. She was able to whisper without a

33
   Systemic lupus erythematosus is “a chronic, inflammatory, often febrile multisystemic disorder of connective
tissue that proceeds through remissions and relapses; it may be either acute or insidious in onset and is characterized
principally by involvement of the skin …, joints, kidneys, and serosal membranes.” Dorland’s at 1080.
34
   Methylprednisolone is “a synthetic glucocorticoid derived from progesterone, used in replacement therapy for
adrenocortical insufficiency and as an anti-inflammatory and immunosuppressant in a wide variety of disorders.”
Dorland’s at 1154.

                                                          19
broken voice. Petitioner explained this by saying speaking in a normal voice caused a strain on
her face and neck muscles.
        Petitioner’s shoulder shrug was 5 out of 5. She had normal bulk and tone. She had a
jerky vertical tremor of her head which waxed and waned in intensity depending on her level of
exertion. Tremor also affected her arms and legs. Her strength was 5 out of 5 proximally in the
upper extremities including deltoids, biceps, and triceps. Petitioner had mild weakness (4+ out
of 5) in wrist extension, finger extension, and finger flexors on the left hand. She was strong in
these groups on the right. Her lower extremity strength was notable for some component of
giveaway weakness. Id. Her reflexes were 2+/brisk in her bilateral biceps, triceps,
brachioradialis, patellae, and Achilles. She did not have clonus. Her toes were downgoing
bilaterally. She had intact and symmetric sensation to light touch and temperature proximally
and distally. Her vibratory sensation was intact. Her finger-nose-finger coordination was slow
and brought out severe vertical head tremor as did heel-to-shin testing. She was able to stand
without assistance. Her gait was narrow-based. After taking 2-3 steps, she began to have severe
shaking of her head in a vertical motion and then a bouncing motion of her legs as if her knees
were going to give way. She asked to sit down. Id.
        Petitioner’s lab studies showed erythrocyte sedimentation rate on September 26, 2009 of
12, negative results for: ANA, anti-double stranded DNA, lupus, Epstein Barr virus (“EBV”)
IgM. Her EBV IgG was greater than 5, and her EBV viral capsule antigen IgG was 3.8 high. On
September 17, 2009, her C-reactive protein was low titer negative, cortisol was 10.7, ANA was
detected at 1:80, and HIV western blot negative. A lumbar puncture on September 24, 2009
showed zero white blood cells, and a protein of 24. Her Lyme antibodies were negative. Id. On
October 4, 2009, petitioner’s erythrocyte sedimentation rate was normal at 6 mm/hr when normal
is 4-25. Med. recs. Ex. 55, at 66. On October 4, 2009, petitioner’s ANA was positive at 1:320.
Her Lyme disease antibody was negative. Id.
       Petitioner’s September 17, 2009 brain MRI was normal with no mass hemorrhage or
extra-axial fluid. She had mild left maxillary sinus membrane thickening. A chest CT on
September 13, 2009 showed soft tissue in the anterior mediastinum probably residual findings
without mass effect. A head CT done on September 12, 2009 was normal. Dr. Sharrief
reviewed the September 17, 2009 brain MRI. The T1 and T2 images showed no signal
abnormality. Id. There was no evidence of masses, ischemic stroke, bleeding, or a
demyelinating process. Med. recs. Ex. 2, at 14.
         Dr. Sharrief’s assessment was petitioner did not have significant medical problems until
four weeks before she came to Johns Hopkins. Her presentation began with what seemed like a
viral illness. She had constitutional symptoms and upper respiratory symptoms. She was
admitted to another hospital and found to have elevated CK and elevated liver function tests.
These tests eventually normalized. She had progressive symptoms including some
lightheadedness, many episodes of syncope, tremor in her head, pain in her neck and face which
affected her voice, and inability to ambulate because of perceived weakness in her legs. An
extensive workup included brain MRI, lumbar puncture, and multiple laboratory studies, none of
which were revealing. Her ANA was positive with a low titer of 1:80. Lyme studies were

                                                20
negative. Inflammatory markers were not elevated. She began on doxycycline and prednisone,
but there was no evidence to begin these drugs. Petitioner’s neurologic examination had many
components which were not physiologic. Nevertheless, it was possible that her viral syndrome
had persistent effects which debilitated her. She could have had exposure to ticks within weeks
of her initial presentation. Tickborne illness might explain some of her symptoms, but not many
of her neurologic complains. Dr. Sharrief thought there was currently a likely component of
“psychological overlay contributing to her symptoms.” Id.
        Dr. Victor C. Urrutia, a neurologist, assessed that petitioner’s symptoms clearly had a
strong psychogenic component but noted that petitioner did have elevated liver enzymes and
CPK, and could have had a mild post-vaccination reaction with neurological symptoms. Id. He
reassured petitioner that she did not have GBS and there was no evidence that she had SLE or
Lyme. He recommended she stop taking doxycycline and prednisone. He thought if the workup
were negative, she might have had a mild reaction and she would get better soon without specific
treatment. Petitioner told him she saw a psychologist that ruled out stress. Petitioner was
admitted because she could not walk. Id. and med. recs. Ex. 55, at 12. A neurology progress
note dated October 3, 2009 states astasia-abasia.35 Med. recs. Ex. 55, at 85.
      On October 3, 2009, petitioner had a brain MRI, which did not show an acute process or
abnormal enhancement. Id. at 15.
        On October 4, 2009, Dr. Urrutia further evaluated petitioner. Med. recs. Ex. 2, at 10.
Petitioner stated she felt better and was able to walk backwards and sideways but still not
forward. A physical therapist mentioned dystonia to her. After receiving Ativan36 the prior
night, petitioner felt much better. An MRI of her brain was normal. On examination, petitioner
continued to stutter when she spoke but talked normally if she whispered. She did not have any
focal deficits. She was able to get off the bed and walk normally backwards, but when she
walked forward, she buckled and seemed jerky, but did not fall or hit herself. She managed to
turn around and sit on the bed. Dr. Urrutia’s assessment was that petitioner had “symptoms that
do not fit a physiologic paradigm.” Id. Her symptoms might be a reaction due to anxiety. He
suggested petitioner see a therapist. He prescribed clonazepam37 for management of her
symptoms as they were likely related to anxiety and because she felt better after taking Ativan.
His impression was speech dysfunction and gait dysfunction. Id. On the same day, petitioner
was discharged.
        On October 4, 2009, Dr. Christopher B. Oakley wrote the discharge summary. Med.
recs. Ex. 55, at 6. Under the impression that petitioner received flu vaccine on August 30, 2009,

35
   Astasia-abasia is “motor incoordination with an inability to stand or walk despite normal ability to move the lower
limbs when sitting or lying down, a form of hysterical ataxia.” Dorland’s at 167. Ataxia is “failure of muscular
coordination; irregularity of muscular action.” Id. at 170. Hysterical ataxia is “ataxia that is part of a conversion
disorder.” Id. at 171.
36
   Ativan is “trademark for preparations of lorazepam.” Dorland’s at 173. Lorazepam is “a benzodiazepine with
anxiolytic and sedative effects, administered orally in the treatment of anxiety disorders and short-term relief of
anxiety symptoms and as a sedative-hypnotic agent.” Id. at 1074.
37
   Clonazepam is “a benzodiazepine used as an anticonvulsant in the treatment of Lennox-Gastaut syndrome and of
atonic and myoclonic seizures and as an antipanic agent in the treatment of panic disorders.” Dorland’s at 373.

                                                         21
Dr. Oakley wrote that petitioner developed URI symptoms that progressed to severe fatigue and
muscles aches, but she continued to work. Petitioner told Dr. Oakley that she was told she had
lupus and Lyme disease. MRIs of petitioner’s cervical, thoracic, and lumbar spine were normal
as was a brain MRI. After receiving Valium,38 she improved. With no other intervention, her
symptoms improved and she was discharged on clonazepam. Her symptoms were thought to be
a stress reaction to what happened weeks earlier when her liver enzymes and CPK were elevated.
Her symptoms might be an anxiety reaction, which was explained to her. She was advised to
undergo physical therapy and have psychological support with a therapist or psychiatrist. “She
was also informed that the relationship with the flu vaccine was not clear.” Id. She was
expected to improve on clonazepam, positive encouragement, and time. Id. Petitioner was able
to speak without abnormalities in a soft whisper with some mild stuttering that improved with
encouragement. Id. at 7. Her eyes did not have nystagmus. On motor examination, she had
normal bulk and tone. Her strength was 5 out of 5 in all extremities. Her reflexes were 2+/brisk
with no clonus and downgoing toes. Finger-nose-finger was slow and brought out severe
vertical head tremor as did heel-to-shin-testing. She was able to stand without assistance. Her
gait was narrow-based. After taking two to three steps, she began to have severe shaking of her
head in a vertical motion, then began to have a bouncing motion of her legs as if her knees were
going to give way, but she did not fall. Her gait improved with reassurance and encouragement.
        On October 6, 2009, petitioner visited her PCP Dr. Ho. Med. recs. Ex. 22, at 12.
Petitioner reported that when she touched her anterior left thigh or fastened a belt around her left
thigh, she could walk completely normally. Id. When she did not do this, she could only run
forward, but she could walk backward and sideways normally. Id. She also reported that her
difficulty with talking was relieved by placing a hand on her chin. Id. Petitioner also claimed
that when she took her husband’s 5mg Valium tabs, she was “perfectly normal” for about 10
hours. Id. She had plans to see a dystonia specialist at Mayo Clinic in November 2009. Id.
Upon physical examination, Dr. Ho noted that petitioner was well-nourished and well-groomed,
and had normal strength and tone overall with no atrophy, spasticity or tremors while seated. Id.
at 14. Dr. Ho suggested that if further extensive workups were unrevealing, he would strongly
consider a conversion disorder, delusional disorder, or other psychogenic etiology. Id. at 14.
        On October 7, 2009, petitioner completed a Vaccine Adverse Event Reporting System
(“VAERS”) form, giving the wrong date of vaccination, August 30, 2009, and stating onset was
on September 3, 2009 at 6:20 a.m. Med. recs. Ex. 3, at 2. She described the adverse event
symptoms as sore throat, nasal congestions, followed by fever, body aches, chills, and headache.
She states she was hospitalized for eight days and her reaction resulted in permanent disability.
She states that three days after her flu vaccination, on September 3, 2009 (which was 10 days
after her flu vaccination on August 23, 2009), she came down with flu-like symptoms. On
September 12, 2009, she began fainting and going into violent convulsions. Two weeks later,
her legs began to fatigue and her neck began to shake periodically. On September 23, 2009, she
lost the ability to walk and walked as if she had MS. She could not walk straight and her entire

38
  Valium is “trademark for preparations of diazepam.” Dorland’s at 2020. Diazepam is “a benzodiazepine used as
an anti-anxiety agent in the treatment of anxiety disorders and for short-term relief of anxiety symptoms, … also as a
skeletal muscle relaxant, anticonvulsant, antitremor agent, antipanic agent . . . .” Id. at 512.

                                                         22
body shook when she walked. Id. On September 24, 2009, she lost the ability to talk (stuttering)
and had neck pulls and strains when talking. Her symptoms continued and she was diagnosed
with dystonia. Id. at 3.
       On October 9, 2009, petitioner saw Dr. Christine M. Cosgrave, a psychologist, for her
cognitive and emotional issues.39 Med. recs. Ex. 45, at 1-3. Petitioner displayed significant
physical and neurological difficulties and Dr. Cosgrave recommended that petitioner seek an
evaluation by a neurologist and neuropsychologist. Id. at 2. Dr. Cosgrave referred petitioner to
Dr. Sidney W. Binks III, a clinical neuropsychologist, for a neuropsychological evaluation. Id.
         On October 12, 2009, petitioner saw physical therapist Dallas A. Simons, a visit that Ms.
Simons described in a letter entitled “To Whom It May Concern,” dated May 12, 2010. Med.
recs. Ex. 16, at 1. Petitioner told PT Simons that she had a muscular problem, which she felt was
a complication of flu vaccination. On October 12, 2009, PT Simons evaluated petitioner’s gait
and found petitioner could walk backward fairly normally, but was very ataxic walking forward.
If petitioner held her thigh, she could walk much more normally. Petitioner spoke very softly,
but if she held her chin, her volume and cadence improved. PT Simons felt this was beyond her
competency to evaluate and did not complete a formal evaluation. PT Simons gave petitioner the
name and phone number of a physical therapist more experienced in neurological problems and
dystonia and did not provide petitioner with treatment. Id.
        On October 13, 2009, petitioner saw Dr. Ho, requesting a medical letter supporting
extension of her disability benefits. Med. recs. Ex. 22, at 9. She said that when she touched her
anterior left thigh or fastened a belt around her left thigh, she could walk completely normally.
When she did not do this, she could only run forward, not walk, but she could walk backward
and sideways normally. Her difficulty talking was eased by placing a hand on her chin. She was
discharged from Johns Hopkins on Klonopin40 but, after her first dose, she had “convulsions.”
Id. When she took one of her husband’s Valium tablets, she was perfectly normal for about 10
hours. Id. Dr. Ho discussed petitioner’s findings in her rather extensive work up and said if
further extensive workups at academic centers were unrevealing, he “would strongly consider a
conversion d/o [disorder], delusional d/o, or other psychogenic etiology.” Id. at 10 and 11. Dr.
Ho performed a physical examination and found her reflexes normal, but her gait broad-based
“(VERY ERRATIC [Dr. Ho’s emphasis])”, spastic, stamping (sensory ataxia) and waddling. Id.
at 11. Dr. Ho provided a letter to excuse petitioner from work or school due to her “undergoing
work up and treatment for dystonia of uncertain etiology.” Id. at 38.

39
   Petitioner first met Dr. Christine M. Cosgrave on April 10, 2009, when she accompanied her then-husband, B.J.,
for an initial psychotherapy intake session for him. Med. recs. Ex 187, at 3. However, by referral from her
physician, petitioner began her own individual psychotherapy with Dr. Cosgrave on October 9, 2009 to obtain
cognitive and emotional help “associated with possible reaction to an influenza vaccine she reportedly received in
September 2009.” Id. Subsequently, petitioner obtained services from Dr. Cosgrave on October 9, 2009, December
7, 2009, February 12, 2010, and March 5, 2010. Id.
40
   Klonopin is “trademark for a preparation of clonazepam.” Dorland’s at 989. For the definition of Clonazepam,
see supra, n.33.

                                                        23
        On October 15, 2009, petitioner and her then-husband saw Dr. Ruben Cintron,41 a
neurologist. Med. recs. Ex. 1, at 10. The history was that within a few weeks of flu vaccination
in August, she developed flu-like and numerous neurological symptoms, including sensory
symptoms. She had a fair amount of difficulty with her motor system, i.e., speech, gait,
movements, tolerance to eating, and syncope, which had been labeled as a dystonic reaction or
disorder related to vaccination. Id. She was initially diagnosed with rhabdomyolysis with a
CPK in the 13,000 range and elevation of her liver enzymes. MRI of the brain, spinal fluid
analysis, and multiple serologies were all unremarkable. She could not walk forward or
sideways,42 only backward. When she walks, she has jerking episodes. Id. During physical
examination, petitioner was alert and oriented. Her speech was interrupted and non-fluid,
although much better when whispering or singing. Id. at 10. She did not have visual
dysmorphism or dystonic features. Id. at 10-11. When she tried to exert power, she had a fair
amount of clinical rhythmic jerking throughout her shoulder girdles. Id. at 11. At least once,
petitioner lost control with an episode of jerking that seemed to take over her ability to function
motorally. During that time, her heart rate did not seem to have changed, she was aware, and she
came back quickly without lying down. When petitioner tried to walk forward, her legs
collapsed. When she walked backward, she did better. Her reflexes were symmetrical with
downgoing toes. She had normal CSF, brain MRI, test results for Lyme disease and other
serologies. Her CPK elevation ranged from 13,000 to 300. Id. Dr. Cintron’s impression was
that petitioner’s history did “suggest vaccination induced motor disorder, with some dystonic and
myoclonic features.” Id. Dr. Citron did not believe that petitioner had a functional disorder
based on her behavior and the consistency of the behavior. Id. Dr. Cintron prescribed
Cogentin43 and gave petitioner and her then-husband information on plasmapheresis44 and
intravenous immunoglobulin (“IVIG”). Id.
     From October 19-22, 2009 and October 26-28, 2009, and on November 18, 2009, and
December 1, 2009, petitioner had treatments with Dr. Rashid Buttar, D.O.45 at his Center for

41
   Dr. Cintron received his MD at Wake Forest School of Medicine. He did an internship in internal medicine at
Georgetown University Hospital, followed by a residency there in neurology. He did a fellowship in Neuromuscular
Diseases and Electrodiagnostic Medicine at George Washington University Medical Center. In 1995-1996, Dr.
Cintron became board certified in Adult Neurology and Neuromuscular /EMG. He considers himself a general
neurologist with special interest in neuromuscular disorders/EMG, migraines, movement disorders and memory
disorders. Physicians and Practitioners, NEUROSCIENCE CONSULTANTS, PLC, www.nscpic.com/ruben-cintron-m-d/
(last visited Jan. 9, 2019).
42
   This is the first medical record to note petitioner could not walk sideways. In previous histories, she said she
could walk sideways and backward.
43
   Cogentin is “trademark for preparations of benztropine mesylate.” Dorland’s at 382. Benztropine mesylate is “an
antidyskinetic believed to act by partially blocking central cholinergic receptors, so that cholinergic and
dopaminergic activity in the basal ganglia is more balanced; used in the treatment of parkinsonism . . . .” Id. at 209.
44
   Plasmapheresis is “the removal of plasma from withdrawn blood, with retransfusion of the formed elements into
the donor; generally, type-specific fresh frozen plasma or albumin is used to replace the withdrawn plasma.”
Dorland’s at 1456.
45
   The North Carolina Board of Medical Examiners issued a reprimand to Dr. Buttar on March 26, 2010 for not
informing his patients about the types of treatment and therapies he was recommending to them. Dr. Buttar
consented to the reprimand. Licensee Information: Rashad Ali Buttar- DO Full and Unrestricted, NORTH CAROLINA
MEDICAL BOARD,
https://wwwapps.ncmedboard.org/Clients/NCBOM/Public/LicenseeInformation/Details.aspx?EntityID=66840&Pub

                                                          24
Advanced Medicine & Clinical Research in Huntersville, North Carolina. See med. recs. Ex. 59,
at 59-83. Petitioner arrived at Dr. Buttar’s clinic with her then-husband, brother-in-law, Stan
Kurtz,46 and a camera crew on October 19, 2009. Id. at 80. Petitioner heard about Dr. Buttar47
from Generation Rescue. Id. at 304.
        Petitioner gave Dr. Buttar a timeline including her impression she received flu vaccine on
August 30, 2009. Id. at 90. She described waking up on September 3, 2009 with a sore throat
and congestion. That afternoon, she started feeling fatigue and was very hot. She took a
decongestant and two Aleve. After dinner, she started feeling hot and nauseated. She lay on the
couch and had body aches all over, most severely at the hip muscle and biceps where she had
been working out. From September 4-7, 2009, she mostly slept, had no appetite, and was very
lethargic. Her sore throat and congestion continued. Id. From September 8-11, 2009, she went
back to work, but was constantly lethargic and fatigued. She had a mild sore throat in the
morning, continuing congestion, and a green ball of mucus in the morning. In the evening of
September 11th, she drank a glass of wine and two mixed drinks over a four-hour period starting
at 7:00 p.m. At 11:00 p.m., she started vomiting violently and uncontrollably. On September
12th, she woke up very weak, dehydrated, and tired. She drank lots of fluids and ate breakfast.
Around 11:00 a.m., she became very lightheaded and hot, but her hands and feet were cold. Id.
She fainted while sitting on the couch. She lost all muscle control while trying to walk. She
states she began convulsing and hyperventilating in the car. Id. From September 18-20, 2009,
petitioner states she was still lethargic and weak. She “finally figured out I was fainting and
going into convulsions after eating.” Id. Petitioner would eat while lying down to avoid
fainting. She still was congested with greenish yellow mucus each morning. Id. Petitioner
notes that even by September 28, 2009, she still had congestion with yellow and white mucus.
Id. at 95.
         Dr. Buttar stated that petitioner presented to his clinic “in emergent state, in severe
distress with labored breathing, experiencing multiple witnessed, back to back seizures or
contractures, extraordinary gross motor deficits, loss of coordination, absence of fine motor
skills, inability to articulate with dysphonia, and unable to ambulate.” Id. at 74. Petitioner
reported that she had done an 8K race two days previously. Id. Petitioner claimed that she was
able to breathe better while running than at rest. Id. Petitioner lost ten pounds over the last five

licFile=1 (last updated Jan. 16, 2019). On February 10, 2011, the Hawaii Medical Board denied Dr. Buttar’s
application for medical licensure due to the NC Board action. Id. Dr. Buttar lists his area of practice as
occupational and environmental medicine. Id. He was licensed in Texas until 1994. Id. Dr. Buttar does not have
any hospital affiliations. Health, U.S. NEWS & WORLD REPORT, https://health.usnews.com/doctors/rashid-buttar-
626895 (last visited Jan. 19, 2019).
46
   Mr. Kurtz has invented treatments to cure autism and was awarded top 20 “Hall of Fame” status by Generation
Rescue. www.stankurtz.org/about/affiliations.html (last visited Jan. 10, 2019). Generation Rescue is an
organization promoting treatment for autism. www.generationrescue.org/who-we-are/ (last visited Jan. 10, 2019).
47
   Dr. Buttar has a website: https://www.drbuttar.com (last visited Feb. 12, 2019). It states on its home page that
The Center for Advanced Medicine and Clinical Research specializes in addressing the needs of patients suffering
from chronic disease, treatment failures, difficult to diagnose conditions, cancer, autism, cardiovascular disease,
neurodegenerative disease, environmental toxicity, heavy metal toxicity, chemical toxicity, and metabolism
disorders. It also states its treatments are “so effective that even the North Carolina Medical Board is trying to
suppress the truth” and cites to another website: DrButtarTruth.org. Id.

                                                         25
to seven days and experienced inability to “keep foods down.” Id. Dr. Buttar noted that
petitioner experienced nausea, vomiting, and dry heaving throughout the day. Id. at 80. Dr.
Buttar diagnosed petitioner with dystonia by history, acute respiratory distress; acute viral, post-
immunization encephalopathy; allergic reaction to medicinal substance; and rule out heavy metal
toxicity. Id. at 75.
        During the following days after arriving at Dr. Buttar’s office on October 19, 2009,
petitioner received IV chelation therapy to “have ability to speak and walk.” Id. at 68-80. Dr.
Buttar noted on October 19, 2009 that petitioner tolerated the IV well and it made a “huge
difference.” Id. at 70-71. In his note of October 20, 2009, Dr. Buttar stated petitioner was
“ecstatic” and the nursing staff was “celebrating” since petitioner was able to walk into the IV
suite and talk in a normal voice. Id. at 69. On October 21, 2009, petitioner received IV
treatment and hyperbaric oxygen therapy (“HBOT”). Id. at 79. On the same day, petitioner
called Dr. Buttar with complaints of seizing again and her voice going out. Id. at 67. Dr. Buttar
visited petitioner and gave her TD-DMPS,48 and eventually petitioner stated that she felt good.
Id.
        On October 22, 2009, petitioner continued to have the ability to speak and walk and
underwent a quantitative electroencephalogram (“qEEG”). Id. Myra A. Preston,49 Ph.D.,
evaluated petitioner’s qEEG data and concluded petitioner’s left parietal and temporal regions
contained abnormal activity that should be further investigated. Id. at 87-89. During the time
that Ms. Preston thought petitioner was having a seizure, the qEEG recording consisted of
muscle artifact as petitioner had strong muscle contractions in her facial muscles. Id. at 88.
Then the “seizure” subsided and the qEEG returned to baseline. Petitioner applied a cream to
her forearms and the qEEG data began to appear more normal in the parietal and temporal

48
   TD-DMPS stands for transdermal 2,3-Dimercaptopropane-1-sulfonate, which “is a metal chelator approved in
Europe for oral or intravenous use for heavy metal poisoning. Transdermally applied DMPS (TD-DMPS) is used by
some alternative practitioners to treat autism, despite the absence of evidence for its efficacy.” Plasma and urine
dimercaptopropoanesulfonate concentrations after dermal application of transdermal DMPS (TD-DMPS), 9 J MED
TOXICOL 9-15, at 9 (2013).
49
   Ms. Preston has a website called www.siberimaging.com in which she states that she offers through qEEG and
neurofeedback enhancement of central nervous system functioning to promote peak performance, intelligence,
alertness, focus, strength, balance, positive mood, and awareness. She claims she and Kim Phillips, Clinical
Director, developed and patented this in 1993. SIBER IMAGING, WWW.SIBERIMAGING.COM (last visited Jan. 11,
2019). Ms. Preston claims success in training individuals with the following disorders: alcohol & substance abuse,
medical reduction & withdrawal, depression, post-traumatic stress disorder, panic disorder, obsessive compulsive
disorder, bipolar disorder, dementia, eating disorders, attention deficit disorder, attention deficit hyperactivity
disorder, adult attention deficit disorder, chronic fatigue syndrome/myalgic encephalomyelitis, various sleeping
disorders, fibromyalgia, post-viral syndromes, premenstrual stress syndrome, migraine headache, hypertension,
gastrointestinal dysfunction, bowel dysfunction, bladder dysfunction, heart rate regulation, chronic pain syndrome,
vulvodynia pain, dysautonomia, epilepsy seizure disorders, Tourette’s syndrome, tic disorder, autism, autism
spectrum disorders, brain injury, closed head injury, spinal cord injury, anoxic brain injury, and stroke. Id. Chronic
Fatigue Immune Dysfunction Syndrome (“CFIDS”) was the focus of Ms. Preston’s Ph.D. dissertation. Id. She
claims that the reasons CFIDS clients have normal EEG results on conventional EEGs is that they are done with the
client’s eyes closed. Ms. Preston does qEEGs on CFIDS clients with their eyes open, and gets an abnormal response
showing the clients have metabolic encephalopathy. Id. Ms. Preston received her doctorate in Psychophysiology in
1994 from The Union Institute. Id. The North Carolina Medical Board accused Ms. Preston of practicing medicine
without a license through her company Siber Imaging, and selling a BrainMaster “brain mapping machine.”
Medicine, COURTHOUSE NEWS SERVICE (Feb. 22, 2011), http://www.courthousenews.com/medicine-2.

                                                         26
regions for 10 to 15 minutes. However, neither region became completely normal. Ms. Preston
did not see any additional seizures and petitioner began to speak normally. Id. During the next
21 minutes, petitioner applied more of the cream and the qEEG maintained improvements. Id.
Ms. Preston characterized the one seizure as an absence seizure. Id. In addition, Ms. Preston
added that, in her experience, “the data acquired from the left temporal and parietal regions most
resemble data correlated with myoclonic seizures,” and went on to note that medical literature
identifies these types of findings with acute insults. Id. at 89. However, Ms. Preston also noted
that “this evaluation should not be considered diagnostic.” Id. at 87.

       While seeking treatment at Dr. Buttar’s office, petitioner’s urine tests revealed high levels
of mercury, nickel, copper, lead, zinc, and manganese. Id. at 16-40. Petitioner’s urine test
revealed low levels of molybdenum. Id. at 42.
        On October 30, 2009, petitioner visited Dr. Cintron for a neurological follow-up. Med.
recs. Ex. 1, at 13. She reported that she had been working in Charlotte with chelating therapy
and felt that she was making progress. Dr. Cintron thought petitioner had a minor seizure in his
waiting area but by using a compound that Dr. Buttar gave her, she dropped into her forearm and
was able to calm down. Her speech seemed somewhat easier to understand. Id. Dr. Cintron also
ordered an EEG, the result of which was normal. Id.
      On December 7, 2009, petitioner saw Dr. Cosgrave again and her gait and speech had
“somewhat improved.” Med. recs. 45, at 2.
        Also, on December 7, 2009, petitioner visited Dr. Randolph R. Stephenson, a neurologist.
Med. recs. Ex. 22, at 36-37. Petitioner stated that in September, she was hospitalized for
rhabdomyolysis following either a viral illness or flu vaccination. Afterward, she started
developing problems with walking and speech. She felt as though she had difficulty moving her
legs while walking, but “remarkably,” she had no problems running. Id. at 36. She had
problems with stuttering. She said numerous doctors suggested she might be having a stress
reaction and suggested she see a neuropsychologist. She was going to North Carolina for
chelation therapy, “although it is unclear what is being chelated.” Id. She reported that she was
having frequent “seizures” at the rate of around 60 per day, during which she would shake
frequently. She denied losing consciousness or having urinary incontinence during these
episodes. She did not appear to be having these episodes anymore at the same frequency. Id. at
36. Petitioner also reported that she continued to exercise regularly, but after running she
sometimes passed out. Id.
        On physical examination, petitioner’s blood pressure was 166/86. Id. at 37. Dr.
Stephenson noted petitioner had normal cognition, comprehension, and vocabulary, but
frequently talked in a British or Australian accent. Id. Petitioner said it was part of the changes
in her speech. Id. She also had frequent stuttering. Petitioner had normal muscle bulk, strength,
and tone. Id. When Dr. Stephenson asked her to point or hold or write something, petitioner
would start shaking her head and hands vigorously. The tremor would be in several planes of
direction and was highly distractible. There was also a highly suggestible component to it so that
Dr. Stephenson could easily bring out the tremor just by having petitioner talk about it. She had
normal light touch, pinprick, temperature, and vibratory sensation. Her reflexes were 1 to 4 and
                                                27
symmetric at the biceps, triceps, patellae, and ankles. Her toes were downgoing. Petitioner had
a “very clear” astasia-abasia gait when walking. Id. She would often appear off balance without
actually falling. When Dr. Stephenson watched her closely, he saw clearly that her balance was
actually better than average given some of the positioning her body took while walking. Id. Dr.
Stephenson’s stated he was not entirely sure what caused all of petitioner’s movement
complaints. However, he wrote she had “a very clear functional component to the majority of
her exam. There were no neurological findings that would suggest any particular organic disease
process.” Id.
        On December 11, 2009, petitioner saw Dr. Sidney W. Binks, III, Ph.D., at the
recommendation of Dr. Christine Cosgrove, the clinical psychologist. Med. recs. Ex. 19, at 1.
Dr. Binks is a neuropsychologist and clinical psychologist. Id. While giving a history to Dr.
Binks, petitioner said that her MRI had been painful as if she were on fire. Id. at 2. She said that
looking at carpet patterns could cause her whole body to shake and a speech problem. She said
she was having 60 seizures a day. She reported great difficulty with fine motor coordination.
Her mental health history was positive for bulimia at age 13 for one year. She was currently in
psychotherapy with Dr. Cosgrove. Her sister had attempted suicide. Dr. Binks interviewed
petitioner on December 11, 2009 and evaluated her on December 19, 2009 and January 16, 2010
for about seven hours. Petitioner drove herself to and from the testing on both days. She did not
have any muscle contractions or involuntary movement as she entered or exited Dr. Binks’ office
on either testing day. However, on the day of the interview, she walked extremely awkwardly.
She could not walk forward but instead walked sideways. Dr. Binks interviewed her when she
was with her then-husband who often reported her history because she had difficulty speaking
and recalling. Id.
        Petitioner frequently became frustrated during testing when she was asked to pronounce
words. She had muscle contractions and seemed to put great effort into producing the answer.
She also had a stutter. Her arm muscles and face muscles would simultaneously contract during
these times. Her right-sided muscle movement was more pronounced, including her arm and
face. The more frustrated she became, the more the muscle movements increased. Dr. Binks
did not observe these muscle contractions during general conversations. Her general speech had
somewhat of a British accent. Her volume would occasionally be high-pitched. Id.
        Petitioner reported she had difficulty focusing on a page when asked to perform certain
tasks such as sentence comprehension, and she used a piece of blank paper with a small cut in
the middle to read line by line. She would spell a word out loud as she wrote it on the paper
because she indicated that made it easier. She said attempting to look at pages gave her a
headache. Id. Petitioner had great difficulty pressing her finger down on a button and had
muscle contraction increase in the finger tapping test. Id. at 3. Petitioner reported that some of
her physical complaints had lessened, but her speech and cognitive symptoms had recently
worsened. Id.
        Dr. Binks also conducted a personality/psychopathology test in addition to the interview.
Id. Petitioner’s validity scales suggested that she was “uncomfortable acknowledging personal
faults” and presented herself in an extremely positive light by denying many minor faults and

                                                28
shortcomings that most people acknowledge.” Id. Dr. Binks noted that “this level of virtuous
self-presentation is uncommon and likely resulted in an underestimate of personality-related
clinical findings.” Id. Dr. Binks stated that due to petitioner’s preoccupation with physical
health concerns, “she is likely prone to developing physical symptoms in response to stress.” Id.
at 4. Dr. Binks concluded, “Problems with her emotional life, thought process and behavior
could not be ruled out given the tendency to under-report even normal psychological
imperfections.” Id. Dr. Binks’ impression was that petitioner had weakened, but not impaired,
cognitive skills. Id. Dr. Binks believed that intensive speech and language evaluation/therapy
should be pursued, working on lowering petitioner’s expectations to realistic levels could be
helpful, and stress reduction techniques would be useful. Id. Although petitioner’s cognitive
skills were currently weakened, Dr. Binks did not consider them impaired but at functional
levels. He suggested psychotherapy to help lower her perfectionism to realistic levels. Dr. Binks
noted petitioner was under tremendous stress and he suggested stress reduction. He stated, “She
would do well to avoid the pull toward being a public spokesperson for others and instead focus
on her own wellbeing and rehabilitation. It is clear that stress exacerbates her symptoms.” Id.
        On December 18, 2009, petitioner saw Dr. Cintron for a neurological follow-up. Med.
recs. Ex. 1, at 14. Petitioner’s gait and speech were better, but she still had difficulty walking
unless she walked sideways, and her speech tone changed during her visit. The EEG50 done in
Charlotte implied petitioner had epilepsy, but Dr. Cintron did an EEG himself and it was normal.
He looked at the Charlotte EEG with petitioner and did not see any abnormalities. Petitioner
“alleged” [Dr. Cintron’s verb] that her heart beat went to almost 200 when she exercised and Dr.
Cintron told her to stop exercising until she saw a cardiologist. He states, “Ultimately, this
appears to be a very complicated situation with post vaccination disorder. . . .” Id.
        On December 18, 2009, petitioner saw Dr. Mark P. Tanenbaum at the Cardiovascular
Group, P.C., for a cardiology assessment for her increased heart beat while running. Med. recs.
Ex. 13, at 7. Petitioner said she received flu vaccine on August 23, 2009 and, within a couple of
weeks, she developed apparent flu-like symptoms, neurologic symptoms, and sensory symptoms.
She had some motor, gait, and speech abnormalities. She had an episode including syncope on
September 12th after eating. She was admitted to Loudoun Hospital which diagnosed her with
rhabdomyolysis. She was discharged on September 14th but readmitted on September 17th with
recurrent syncope. She was discharged, but she was readmitted with similar symptoms at Fairfax
Hospital on September 26th. She said she was told she may have GBS related to her flu
vaccination. She went to Johns Hopkins University Hospital and was treated with Ativan and
Klonopin. She had an EEG which was normal. She went to Charlotte, NC, for chelation therapy
to remove apparent excess mercury. She had been usually quite active, running three miles in 25
minutes. During the last several months, when she ran, her heart rate would increase more
quickly up to 180 beats a minute associated with fatigue. Id. In a review of systems, Dr.
Tanenbaum wrote petitioner denied any difficulty speaking. On physical examination, petitioner
did not have any gross motor or sensory deficits. Id. at 8. Dr. Tanenbaum’s impression was

50
 This must be the qEEG that Ms. Preston did since there is no other EEG that petitioner underwent while staying in
North Carolina to receive evaluation and treatment from Dr. Buttar.

                                                       29
“apparent vaccination-induced motor disorder, along with apparent dystonic and myoclonic
features.” Id. Dr. Tanenbaum suspected that petitioner’s elevated heart rate represented sinus
tachycardia, which “might be exacerbated by her ongoing problem with apparent vaccination-
induced motor disorder, along with apparent dystonic and myoclonic features.” Id. at 8.
       On December 21, 2009, petitioner had a stress echocardiogram. Id. at 11. Dr. Nick
Cossa concluded petitioner had a normal stress echocardiogram without evidence of ischemia.
She had a normal heart rate and blood pressure response to exercise, normal exercise capacity,
no chest pain, ischemic EKG changes, or left ventricular wall motion abnormalities with
exercise. She had a transient syncope after exercise secondary to neurocardiogenic hypotension.
Id.
         On December 28, 2009, petitioner went to a follow up appointment with Dr. Cintron.
Med. recs. Ex. 1, at 15. He thought petitioner walked better and her speech was more fluid. She
still had an “accent” [quotation marks are by Dr. Cintron]. She sounded dystonic and still had
some occasional syncopal episodes although her blood pressure in Dr. Cintron’s office was fine.
Apparently, she had a syncopal episode while on a treadmill in the cardiologist’s office, but the
office felt she did not have arrhythmia. Petitioner found that Valium allowed her to run better
and she took it sporadically. She still had better heat intolerance to some extent, and she was
better with not being overwhelmed in a stimulating environment. Dr. Cintron concluded that
petitioner’s problem was vaccine related consisting of dystonia and possibly some autonomic
problem. Id.
        On January 19, 2010, petitioner saw Dr. Cintron. Med. recs. Ex. 1, at 9. She seemed
better. She had learned that with pain in her left quadriceps, she was able to walk better because
she got distracted. She also learned that by looking to the left, she could walk straighter.
Petitioner’s speech was significantly better that day. Dr. Cintron thought petitioner had some
type of dystonia related to her insult and he did not believe her situation was functional,
“although certainly there is some bizarre aspects to her disease.” Id.
        On February 5, 2010, Dr. Cintron had petitioner undergo a Transcranial Doppler because
of her vertigo/dizziness and vertebrobasilar51 syndrome. Med. recs. Ex. 1, at 22. The result was
normal. He also checked her carotid arteries for stenosis52 because of transient ischemic attacks.
Id. at 23. The result was no significant stenosis in the right internal carotid artery and minimal 1-
15% stenosis in her left internal carotid artery. Both external carotid arteries had no significant
stenosis. Id.
        On February 5, 2010, petitioner went to the Reston Hospital ED, complaining of
vomiting. Med. recs. Ex. 50, at 5. This started the day before. Id. at 6. Petitioner said she felt
dizzy on standing and had increased thirst. On physical examination, her motor exam was
normal in all extremities and her sensory exam intact. She had no abnormalities on the
cerebellar exam. Her cardiac rate and rhythm were normal. Her extremities were normal.
Petitioner told Dr. David Kruse that she had autonomic dysfunction after a flu shot. Id.

51
     Vertebrobasilar pertains to vertebrae and arteries. Dorland’s at 2051.
52
     Stenosis is “an abnormal narrowing.” Dorland’s at 1769.

                                                            30
Petitioner had driven herself to see Dr. Cintron that morning and “developed a syncopal episode
with thickened speech with a British accent and inability to walk.” Id. at 12. Her glucose was
low at 73 when the normal range is 74-106 mg/DL. Id. at 19. Dr. Kruse diagnosed petitioner
with clinical dehydration and discharged her. Id. at 7.
         On February 8, 2010, petitioner went to Inova Fair Oaks Hospital Rehabilitation Center
Speech-Language Pathology (SLP) for an evaluation, to which Dr. Cintron sent her. Med. recs.
Ex. 17, at 7. The onset of petitioner’s speech difficulty was noted as September 3, 2009. The
history was that petitioner developed an adverse reaction to a flu vaccination, and was
hospitalized for seizures and decreased ambulation. She also developed vasodepressor syncope
and reported a decrease in speech manifesting as stuttering, foreign accent, and blocks. She
stated she had a decrease in doing simple math and in memory. Id. The assessment was
moderately severe cognitive, language processing/mild speech production disorders. Processing
deficits were noted for combined modalities. She had significant breakdowns in attention skills,
including selective and divided. This impacted her ability to complete basic routines of activities
of daily living (“ADLs”). When petitioner’s cognition, processing, and attention are challenged,
this impacted her verbal expression complicated by dysfluencies/blocks. Id. The pathologist
(whose signature is illegible) wrote petitioner would benefit from skilled speech therapy
intervention to improve her cognitive skills for ADLs. Id. As part of petitioner’s evaluation, the
therapist noted petitioner spoke English with an Australian accent and when stressed, her speech
became extremely dysarthric with spasmodic head movements which the therapist diagnosed as
transient neurogenic stuttering brought on by stress, cognitive stress vs. distraction and auditory
distraction. Id. at 8. During more testing on February 15, 2010, the therapist noted that
petitioner was able to jog in place to “refresh” herself with more normalized speech afterwards.
Id. at 9. On March 15, 2010, the therapist noted that a low dosage of Valium appeared to
facilitate petitioner’s ability to tolerate multi-modal stimulation and function more optimally. Id.
at 5.
        On February 12, 2010, Dr. Cintron sent petitioner to Cardiovascular Group again.
Petitioner saw Dr. Pradeep Nayak. Med. recs. Ex. 13, at 4; Ex. 53, at 66. Dr. Nayak diagnosed
petitioner with vasodepressor53 syncope, demonstrated following her stress echocardiogram
about six weeks previously. Med. recs. Ex. 12, at 5. He also diagnosed her with “apparent
vaccination-induced motor disorder,” elevated heart rate early in exercise, mild rhabdomyolysis
in 2009, and a leg injury with desire to return to running. Id. He recommended she see Dr.
Walter L. Atiga.
        On February 23, 2010, petitioner saw Dr. Cintron. Med. recs. Ex. 1, at 8. Her speech
was mildly impaired with mild dystonic-type filter. Dr. Cintron found that her
neuropsychological testing was somewhat confusing in his interpretation. He thought it
interesting that when petitioner exercised, she did better.

53
     Vasodepression is a “decrease in vascular resistance with hypotension.” Dorland’s at 2027.

                                                          31
        On February 26, 2010, Dr. Cosgrave, petitioner’s psychologist, mailed a letter to
petitioner’s former attorney. Ex. 11, at 1, and Ex. 45, at 2. She states that the extent of
petitioner’s impairments was beyond her scope of expertise. Id.
        On March 2, 2010, petitioner underwent a brain MRI for foreign accent syndrome.54
Med. recs. Ex. 53, at 68. Dr. Arun Kumar compared the results with petitioner’s brain MRI,
done October 3, 2009. Petitioner’s ventricles, sulci, and cisterns were normal for her age. She
did not have hydrocephalus, abnormal signal intensity in the brain parenchyma, hemorrhage,
mass, mass effect, or midline shift. She did not have evidence of restricted diffusion to suggest
an acute or subacute infarction. Her mesial temporal lobe structures were symmetric. She did
not have evidence of cortical dysplasia. Her flow voids were maintained. There was mucosal
inflammation in the mastoid sinuses, ethmoidal air cells, and frontal sinuses. Her orbits were
normal. Her mastoid air cells were clear. Dr. Kumar’s impression was petitioner did not have an
acute intracranial process and she had mild sinus disease. Id.
        On March 3, 2010, petitioner underwent a F-18 FDG PET/55CT scan of her brain for
cognitive impairment and foreign accent syndrome. Id. at 69. Dr. Stuart A. Fruman compared
the results with petitioner’s brain MRI, done on October 2, 2010. Petitioner had symmetric
distribution of FDG metabolism through her brain parenchyma. She did not have any abnormal
areas of increased or decreased isotope accumulation. Dr. Fruman wrote petitioner had a normal
brain PET/CT scan. Id.
        On March 16, 2010, petitioner and her then-husband saw Dr. Cintron. Med. recs. Ex. 1,
at 7. Petitioner’s PET scan was normal. He told petitioner and her then-husband that he had not
seen any evidence of any irreversible changes to any part of her central nervous system and he
felt confident she would recover. At this point, he empirically labeled petitioner as having
dystonic-type illness with other “not very well explained features and possible autonomic
dysfunction secondary to her vaccination.” Id. She seemed to have an exaggerated vasovagal
syndrome because she faints after eating and exercising. Dr. Cintron states, “From the
neurological perspective the symptoms are still bizarre, she has an accent which fluctuates, she is
able to walk sideways but not forward, but no objective evidence on exam of where the problems
are coming from.” Id.
      On March 23, 2010, petitioner saw Dr. Atiga, a cardiologist, for an evaluation and
management of syncope. Med. recs. Ex. 13, at 1. Dr. Nayak referred petitioner to Dr. Atiga for

54
   “Foreign accent syndrome (FAS) is speech disorder that causes a sudden change to speech so that a native speaker
is perceived to speak with a ‘foreign’ accent. FAS is most often caused by damage to the brain caused by a stroke or
traumatic brain injury. Other causes have also been reported including multiple sclerosis and conversion disorder
and in some cases no clear cause has been identified.” What is Foreign Accent Syndrome?, THE UNIVERSITY OF
TEXAS AT DALLAS, https://www.utdallas.edu/research/FAS/ (last visited Jan. 25, 2019).
55
   Positron emission tomography (PET) is “tomography accomplished by detection of gamma rays emitted from
tissues after administration of a natural biochemical substance (e.g., glucose, fatty acids) into which positron-
emitting isotopes have been incorporated. The paths of the gamma rays, which result from collisions of positrons
and electrons, are interpreted by a computer, and the resultant tomogram represents local concentrations of the
isotope-containing substance.” Dorland’s at 1935. FDG is 18fluorodeoxyglucose. Neil M. Davis ed., MEDICAL
ABBREVIATIONS 144 (12th ed. 2005) [hereinafter “Med. Abbrev.”].

                                                        32
management of vasovagal syncope. Petitioner stated she was healthy and active as a runner until
she started having problems late summer 2009. She received flu vaccine for the third year in a
row. A couple of weeks later, she started having recurrent episodes of syncope preceded by
lightheadedness, warmth, and cold hands and feet. These would always occur soon after eating.
The symptoms got so bad she would take a sip of water and then pass out, having nausea and
vomiting afterwards. She went to Loudoun Hospital, and then Johns Hopkins, but was not able
to get a clear and definitive diagnosis. She was featured on the local channel 5 news because she
thought her symptoms were due to flu vaccine. Having read that news story, an organization that
believes vaccines may cause autism contacted her because her symptoms could be consistent
with mercury toxicity. As a result, she went to North Carolina and underwent chelation
treatment because of elevated levels of mercury. The chelation therapy helped her feel better,
but since it was prohibitively costly, she could not continue with it.
         Presently, petitioner discovered that if she exercised, such as went running, she could eat
without becoming nauseated, vomiting, or passing out. On days when she did not run, she had
presyncope or syncope. She tore her left quadriceps and could not run. Since then, she has had a
recurrence of symptoms so that she cannot eat without passing out. She is very sensitive to heat
and, if she goes out on a warm day, she has lightheadedness, warmth, presyncope, syncope,
nausea, and vomiting. Her then-husband hugged her tightly and compressed her neck at one
point, and she passed out and had seizure-like activity. She had the same symptoms while
undergoing a carotid Doppler examination. At her worst, she was unable to walk forward but
could walk sideways or backward. However, when she began taking Neurontin56 and after the
dosage was increased, she was able to walk forward. Another “interesting” symptom was that
she developed what sounds like a British accent although she is from Ohio. Id. at 1. She
increased her salt intake by 2,000 mg of sodium and increased her fluids, but they did not have
an effect. Id. at 1-2. Under job description, Dr. Atiga wrote professional cheerleader. Id. at 2.
        Dr. Atiga’s impression was that petitioner’s symptom complex “does certainly time out
with her receiving the flu vaccination.” Id. Her symptoms were consistent with a vasovagal or
neurocardiogenic mechanism. He writes, “It is interesting that on days when she has heavier
physical exertion, her symptoms are improved enough that she can actually eat,” but on days
when she does not do this, her symptoms are worse. She also seemed to have evidence of carotid
sinus hypersensitivity. Dr. Atiga writes, “I believe that she has an unusual form of
neurocardiogenic syncope in that she has very heightened vagal tone and the reason that the
exercise improves her on that day is because it increases her sympathetic tone.” Id. To reduce
petitioner’s vagal tone, Dr. Atiga offered her either a Scopolamine57 patch or Norpace.58 Either

56
   Neurontin is “trademark for preparations of gabapentin.” Dorland’s at 1268. For a definition of gabapentin, see
supra, n.8.
57
   Scopolamine is “an anticholinergic alkaloid, derived from several solanaceous plants, including Atropa
belladonna, Hyoscyamus niger, Datura species, and Scopolia species. It has effects on the autonomic nervous
system similar to those of atropine. It is used as an antiemetic, particularly in motion sickness.” Dorland’s at 1681.
58
   Norpace is “trademark for preparations of disopyramide phosphate.” Dorland’s at 1291. Disopyramide is “a
cardiac depressant with anticholinergic properties, used as an antiarrhythmic.” Id. at 547. An antiarrhythmic is “an
agent that prevents or alleviates cardiac arrhythmia.” Id. at 100.

                                                          33
drug would put her parasympathetic and sympathetic tone in more balance. He prescribed
Norpace. Id.
        On March 25, 2010, petitioner saw Dr. Cintron. Med. recs. Ex. 1, at 6. He states she is a
very pleasant woman whom he follows for neurological implications secondary to exposure to a
flu vaccine. She was doing significantly better since he increased her Neurontin to 200mg twice
a day. She could walk forward. Her voice sounded much better. but she still had some difficulty
eating unless she exercised. She was working with Dr. Atiga to help with her dysautonomia. Id.
        Throughout February and April 2010, petitioner sought treatment at the Physical
Medicine and Rehabilitation unit at Inova Fair Oaks Hospital. Med. recs. Ex. 53, at 41-59.
Petitioner sought cognitive treatment that focused on processing multiple stimuli simultaneously
and tuning out extraneous stimuli. Id. at 41. Through a hierarchy of graduated attention tasks
and possibly a change in medications to help control her dystonia, Wendy Morgan, MS, CCC-
SLP, wrote that petitioner had made significant gains in all cognitive areas. Petitioner was
discharged because she moved out of the area. Id.
        On May 21, 2010, petitioner saw Dr. Cintron. Med. recs. Ex. 1, at 5. Petitioner was
trying to control her syncopal episodes that occurred when she was overheated. She seemed to
be somewhat able to prevent them by exercising excessively as if she were trying to get her
adrenaline going. Petitioner was seeing Dr. Atiga to see if she could get help with what appeared
to be autonomic imbalance. From a neurological perspective, petitioner continued to have
dystonia and speech difficulty, but had significantly improved over time. She was getting ready
to move to California. Id.
        On May 24, 2010, petitioner saw Dr. Farhad Zangeneh for an endocrine evaluation.
Med. recs. Ex. 43, at 28. Petitioner was on disability and wanted Dr. Zangeneh to evaluate her
adrenal gland, thyroid, and overall endocrine status. Id. A comprehensive metabolic test result
was normal. Id. at 29. Dr. Zangeneh wrote that petitioner’s blood pressure both sitting and
standing was nearly identical, and she did not have orthostatic hypotension. Petitioner was on
Depo-Provera. Dr. Zangeneh discussed with petitioner that, from an endocrine standpoint, he
did not recommend Depo-Provera because of an increased risk for bone loss and for the
development of metabolic syndrome. Id. On June 4, 2010, Dr. Zangeneh informed Dr. Ho that
petitioner’s lab results were normal and there was no endocrine etiology for petitioner’s
symptoms. Id. at 27.
        On July 2, 2010, after petitioner moved to California, she saw Dr. Neil Q. Tran as her
new PCP, at the Mission Internal Medicine Group. Med. recs. Ex. 42, at 28. In his note, Dr.
Tran listed multiple problems including petitioner’s intolerance to heat over 75oF, anxiety,
dystonia, autonomic dysfunction, dizziness, fatigue, diarrhea, and facial weakness. Id.
        On July 2, 2010, petitioner began keeping a log of events and blood sugar readings. Med.
recs. Ex. 42, at 26. She noted that on July 1, 2010, she last engaged in 30+ minutes of aerobics
at noon. On Friday, July 2, 2010, she did not have any trouble all day eating or drinking. On
Saturday, July 3, 2010, she became nauseated, dizzy, and unable to walk and talk after breakfast.
This continued throughout the day at every meal. Later in the day, meals resulted in diarrhea.

                                                34
On Sunday, July 4, 2010, she had very little appetite. Water now triggered her symptoms.
Immediately after eating breakfast, she went into the hyperbaric chamber to stop her symptoms.
She ate a peach and chicken with water. She became unable to walk or talk, became dizzy, had a
headache, chest pain, and an upset stomach. She found the smell of food disgusting. She had an
upset stomach upon drinking sips of water. She was dizzy when she got out of bed quickly. She
had stomach pain. On Tuesday, July 6, 2010, she had a breakfast sandwich with apricots, a bagel
with cream cheese and salmon, a pomegranate smoothie, and a small bowl of cereal with almond
milk. She lost the ability to walk and talk, and had a painful headache upon simply sipping water
if not allowed to lie down. She ate all her meals lying down. Her blood sugar was 100mg/dl
before breakfast right after waking up, 117mg/dl ten minutes after eating breakfast, 203mg/dl
two hours after eating, 92mg/dl at 2:51 p.m., and 82mg/dl at 7:29 p.m., which was two hours
after eating. On Wednesday, July 7, 2010, she had a breakfast sandwich with apricots. She lost
the ability to walk and talk, and had a headache when not able to lie down. She was extremely
tired. She slept most of the morning. She felt she might be coming down with a cold because
she had a sore/swollen throat, felt weak, and had a heavy chest for the prior couple of days. She
had a lot more irritability with throbbing pain in her teeth. Her blood sugar was 82mg/dl before
breakfast right after waking up, 99mg/dl two hours after eating, 125mg/dl at 4:45 p.m., and
97mg/dl before going to bed at 8:47 p.m. Id.
        On July 12, 2010, petitioner was tested for levels of epinephrine and norepinephrine in
her urine. The results were reported on July 16, 2010. Med. recs. Ex. 42, at 41. Her total was
low at 1559 when normal should be 26-121.
        On July 15, 2010, Dr. Atiga conducted a tilt-table test. Med. recs. Ex. 23, at 1. Upon
upright tilt, petitioner immediately developed slurred speech that progressively worsened over
the next 15 minutes so that she could not speak at all. This occurred despite her having normal
peripheral blood pressure and heart rate. She was then provoked with 0.4mg sublingual
nitroglycerin and, shortly thereafter, she became dystonic, progressing to more severe dystonia,
with tonic/clonic movements without loss of consciousness. Her blood pressure was 169/123
with a heart rate of 120 beats per minute. She was laid flat with her legs elevated. Petitioner had
rapid resolution of dystonia, but her slurred speech persisted for nearly one hour. Id. Dr. Atiga
wrote petitioner might have a form of cerebral syncope in which she had dysregulation of
cerebral blood flow to upright posture, especially with orthostatic stress. Id. at 2.
        On August 4, 2010, petitioner saw Dr. Frisca Yan-Go, a neurologist, at UCLA Health
System on the recommendations of Dr. Cintron and Dr. Atiga. Med. recs. Ex. 18, at 2.
Petitioner saw Dr. Yan-Go for dysautonomia, the main component of which was syncopal attack
when standing, but also inability to eat or drink without her body expelling food or liquid. She
needed to engage in 10 minutes or more of aerobic activity before she could tolerate eating.

59
   Low levels of epinephrine and norepinephrine can contribute to a variety of physical and mental conditions,
including: anxiety, depression, fibromyalgia, hypoglycemia, migraine headaches, restless leg syndrome, and sleep
disorders. Chronic stress, poor nutrition, and taking certain medications, such as methylphenidate (Ritalin) can
make someone produce less epinephrine and norepinephrine. What’s the Difference Between Epinephrine and
Norepinephrine?, HEALTHLINE NEWSLETTER, https://www.healthline.com/health/epinephrine-vs-norepinephrine
(last visited Jan. 8, 2019).

                                                        35
Once she stopped exercising, she could not eat and quickly lost weight and became severely
dehydrated. She is very intolerant to heat and humidity. She cannot lift her legs to walk, her
speech becomes slurred and she has nausea, dizziness, and profuse sweating. After eating, she
gets very dizzy. Sometimes, when she has to talk or gets short of breath with chest pain, this
triggers a dystonic reaction in which her jaw tightens, she slurs her words, and she adopts
abnormal positioning of her extremities, all while she is conscious. She had a tilt-table test on
July 15th and apparently her blood pressure did not change much, but her heart rate increased
from 70 to 125, and she had presyncope, resulting in stopping the test. Id.
        Dr. Yan-Go went through petitioner’s history. She received her first flu shot in October
2007 and had flu symptoms. She received her second flu shot in October 2008 and developed a
flu and bronchitis pneumonia 30 days after the shot. On September 3, 2009, she had her third
seasonal flu shot [this is incorrect; her flu vaccination in 2009 occurred on August 23, 2009; Dr.
Yan-Go is basing this history on petitioner’s recounting her history to her]. Petitioner said she
had total body aches and fatigue. Nine days later, on September 12, 2009, she could not move
much, was very fatigued, and went to the hospital which said she had increased creatine kinase
and diagnosed her with rhabdomyolysis. On September 17, 2009, she saw an infectious disease
specialist who thought she might have Lyme disease. Her speech got worse and she felt fatigued
and weak. In retrospect, they thought she might have a form of postinfectious GBS.
        On September 27 and 28, 2019, petitioner had low orthostatic tolerance and orthostatic
hypotension, but not a full faint. By October, she had to lie down most of the time. In December
2009, she fainted again. In March 2010, she saw an endocrinologist and other specialists who
said she might have a form of GBS-like symptoms which triggered a dysautonomia. The
dysautonomia fluctuated in intensity intermittently. She could not change position from sitting
or bending to standing without being dizzy or fainting. Norpace controlled it 60 percent. She
cannot hold her breath for more than five seconds without becoming dizzy and then she loses
some speech and the ability to walk. Even at 75 degrees in temperature, she has extreme fatigue
and then chest pain and headache especially when she was walking and standing. She slept quite
well and sometimes had to sleep for 10 hours at night and four hours in the day. Id.
        She gets depressed if she cannot exercise. She cannot tolerate stress without sharp chest
pain, slurred speech, weakened muscles, and dizziness. She has extreme difficulty eating and
consuming or retaining water if she cannot complete 10 to 20 minutes of exercise like running,
biking, rowing, or stair stepping. Then her symptoms would return and she could not tolerate
food. She cannot control her leg muscles without Neurontin. Sometimes, she can soothe the
dystonia with a sensory trick like touching her left eye. She cannot tolerate multiple noises,
sounds, or flashing lights, which result in a “violent convulsion,” but she has 90 percent control
with low-dose Neurontin. She cannot multitask and has intermittent difficulty speaking, which
speech therapy did not improve. Id. Many times, she has extreme difficulty with cognition
concerning calculating, remembering things, strategizing, and recalling, but she did not mention
whether she improved in a supine position from being upright. Id. at 2-3. Her Epworth
Sleepiness Scale was 15, with normal being less than 9. Id. at 3. She has been observed to have

                                                36
sleep talking and sleep walking. Her Beck Inventory60 is rated slightly elevated at 14 with
normal being less than 9. Id.
        On physical examination, Dr. Yan-Go notes that petitioner was not orthostatic. Id. at 3.
Dr. Yan-Go hyperventilated her for only 10 seconds. Her eyes looked glassy, but she was still
conscious and then she went into almost a tetany61 state. Her jaw locked and her extremities
went dystonic for about 10 to 15 seconds. Dr. Yan-Go told her to close her mouth and stop
hyperventilating. Petitioner then came back to baseline in 30 seconds. Dr. Yan-Go wrote this
was more of a tetany reaction to respiratory alkalosis and not the usual chronic dystonic
syndrome because petitioner did not have dystonic posturing in baseline except when she was
being hyperventilated. Dr. Yan-Go put petitioner on a bed and was able to get her to breathe
very slowly. She was able to breathe about 20-30 seconds without dystonic posturing if she
breathed slowly and was recumbent. Id. Dr. Yan-Go noted petitioner did not have Raynaud’s
phenomenon62 and had some increased sweating while she was hyperventilating.
         In her assessment, Dr. Yan-Go writes:
                  This is a very complex set of symptomatology. It is very hard to
                  put it all together, but the way I analyze it is that she is born with
                  normal nervous system and autonomic nervous system.
Id.
        On August 25, 2010, petitioner saw Dr. Yan-Go again. Id. at 1. Dr. Yan-Go states
petitioner “has a very complex symptomatology, many of which I cannot explain by unified
disorder.” Id. Dr. Yan-Go thought petitioner’s tilt-table test was interesting because when she
was tilted, she had dystonic posturing and slurred speech. Dr. Yan-Go thought petitioner had
some symptoms of orthostatic intolerance or maybe POTS, and might have some presyncopal
phenomena, but not full syncopal phenomena. If petitioner did not exercise vigorously for 30
minutes, she could not get a sip of water or a bolus of food without having slurred speech and
she would get very dystonic and fall. She had neurologic testing, imaging, and neuropsychologic
testing without a diagnosis. She was referred to Dr. Yan-Go for dysautonomia. Dr. Yan-Go said
she would not be able to explain all of petitioner’s symptoms such as walking sideways or else
she gets dystonia. Dr. Yan-Go observed all these events that day in her office. Petitioner took
herself off Neurontin and Norpace in the prior two weeks because she had to do that before
undergoing autonomic testing. She told Dr. Yan-Go that she could not tolerate the heat because
she is intolerant of heat and cold temperatures and barometric pressure. Petitioner could not

60
   Beck Depression Inventory is “a self-report questionnaire for measuring the symptoms of depression, focusing on
the cognitive symptoms.” Dorland’s at 955.
61
   Tetany is “hyperexcitability of nerves and muscles due to decrease in concentration of extracellular ionized
calcium, which may be associated with such conditions as parathyroid hypofunction, vitamin D deficiency, and
alkalosis or result from ingestion of alkaline salts; it is characterized by carpopedal spasm, muscular twitching and
cramps, laryngospasm with inspiratory stridor, hyperreflexia, and choreiform movements.” Dorland’s at 1904.
62
   Raynaud’s phenomenon is “intermittent bilateral ischemia of the fingers, toes, and sometimes ears and nose, with
severe pallor and often paresthesias and pain, usually brought on by cold or emotional stimuli or anatomical
abnormality.” Dorland’s at 1430.

                                                         37
swallow one gulp of water in front of Dr. Yan-Go without exercising for 30 minutes. Then she
got dystonic speech. Dr. Yan-Go wrote, “I am really out of ideas today and so I said if she needs
to resume her Neurontin and Norpace so that she could eat and exercise 30 minutes but not
hyperventilate so she would not faint,” she could do so. Dr. Yan-Go suggested petitioner see a
gastroenterologist and take some swallowing tests and motility63 testing to determine if she has
dysmotility of the GI tract. Dr. Yan-Go said she “entertained” the idea that petitioner might have
dysautonomia, but Dr. Yan-Go observed petitioner did not have seizures because petitioner could
talk, this was gradual, and petitioner came back with no change of her sensorium. In addition,
petitioner had an EEG during these spells and the EEGs were normal. “I am worried whether
this also has some functional overlay and subconscious effect of conversion reaction or not.” Id.
Dr. Yan-Go stated it was very difficult, and whether petitioner had true triggers for movement
disorder, dystonic movement was “very very hard to differentiate.” Id.
         On August 26, 2010, petitioner saw Dr. Kevin Ghassemi, a gastroenterologist, at UCLA.
Id. at 8. Petitioner complained that she would vomit if she had not exercised for 30 minutes prior
to eating. Id. However, if she exercised for 30 minutes, she was able to swallow solid food and
liquid for the next 24 hours. Id. In addition, she felt a sense of throat constriction, dizziness,
sweating, chest discomfort, and some slurring of her speech. Id. Petitioner reported that even
drinking water could immediately lead to slurring of speech. Id. Dr. Ghassemi reviewed her
laboratory testing. Petitioner had a normal C-peptide, morning cortisol level, metabolic panel,
lipid panel, and renin-angiotensin-aldosterone64 labs. Her ACTH level was slightly below the
reference range. Id. On physical examination, when Dr. Ghassemi palpated petitioner’s carotid
arteries, she developed slurred speech which immediately improved on lying in the supine
position. Id. at 9. She had a normal gait except for an episode of slurred speech when she
appeared to have unsteadiness. When she developed episodes of slurred speech during carotid
palpation and when she provoked symptoms by drinking water, she had twitching of her eyes
and lips, was unable to stick out her tongue, and had unsteady gait. Id. Dr. Ghassemi’s
impression was, “Dysphagia65 and vomiting in the setting of a complex group of symptoms.” He
found no reason to conclude petitioner had a structural gastrointestinal abnormality, given that
she experienced periods of tolerating both solids and liquids without dysphagia. He stated
petitioner might have a motility disorder but in the setting of her other symptoms, “it is unlikely
that she has a primary gastrointestinal motility disorder.” Id.
        On August 30, 2010, petitioner returned to Dr. Ghassemi after undergoing esophageal
manometry66 and an upper GI series, both of which were normal. Id. at 11. Both tests provoked
a feeling of dysphagia and nausea. Since her manometry, after each meal, within 10 to 15
minutes, petitioner began to experience diarrhea while she was lying down. Subsequently, while
she was sitting to defecate, she would start to vomit. She recalled having similar problems

63
   Gastric motility is “the spontaneous movements of the stomach muscles that grind food and mix it with gastric
secretions, and move the products into the duodenum.” Dorland’s at 1182.
64
   Renin-angiotensin-aldosterone system (RAAS) is “the regulation of sodium balance, fluid volume, and blood
pressure by renal secretions.” Dorland’s at 1862.
65
   Dysphagia is “difficulty in swallowing.” Dorland’s at 579.
66
   Manometry is “the measurement of pressure by means of a manometer.” Dorland’s at 1104. A manometer is “an
instrument for measuring the pressure or tension of liquids or gases.” Id.

                                                       38
lasting about four days when she took an SSRI67 for her symptoms. She worried about becoming
dehydrated. On physical examination, petitioner went in and out of speaking with a British
accent. Petitioner asked Dr. Ghassemi if she had postprandial68 hypotension and he said he
could not find in the literature a specific controlled way of making this diagnosis. Dr. Ghassemi
assumed petitioner had an underlying neurologic disorder, “possibly related to autonomic
dysfunction” without evidence of esophageal dysmotility. Id.
        On September 9, 2010, petitioner had an evaluation of autonomic disorder at The Ohio
State University Department of Neurology. Med. recs. Ex. 13, at 13 and Ex. 37, at 1-2. The tilt
test findings were consistent with grade II orthostatic intolerance or POTS. Med. recs. Ex. 37, at
2. The technologist conducting the test commented that petitioner “experienced symptoms of
feeling hot, focused in her upper trunk and head, with slight diaphoresis.69 The patient’s hands
and feet were cold and moist to the touch.” Id. at 1. Dr. Sheri Hart wrote that the tilt test
findings were consistent with Grade II Orthostatic Intolerance (Postural Orthostatic Tachycardia
Syndrome). Id. at 2. Petitioner’s heart rate-deep breathing study was normal. Her blood
pressure and pulse pressure were normal, but variable during 15 minutes of orthostatic stress.
Her heart rate variability in response to deep breathing was normal. Id.
        On September 14, 2010, petitioner saw Dr. Yan-Go. Med. recs. Ex. 18, at 6. Dr. Yan-Go
reviewed Dr. Kevin Ghassemi’s complete GI test. Petitioner did not have a structurally
abnormal GI problem and no true dysfunctional GI problem in motility. Dr. Yan-Go’s opinion
was that petitioner did not have a serious, pure, autonomic failure or degenerative dysautonomia.
Dr. Yan-Go was confident that she could treat petitioner’s symptoms to prevent deconditioning
and prevent chronic patterning in her brain that might lead to further disability. Dr. Yan-Go
listed two choices. First, petitioner could have another full diagnostic study at the Mayo Clinic,
but the clinic cannot manage her treatment. Second, she can manage each symptom locally. Dr.
Yan-Go suggested nutritional management and directed petitioner to the website mypyramid.gov
to look at a high-protein, complex-carbohydrate, nutrient-dense diet with fluids and small
feedings. Dr. Yan-Go said petitioner had to condition her nervous system. She told petitioner
not to do aerobic exercises. Dr. Yan-Go preferred petitioner do aquatic exercise in an indoor
pool with controlled light, humidity, and temperature. Dr. Yan-Go said petitioner might have to
repattern her brain by seeing a psychologist for repatterning or cognitive behavioral therapy. She
also had to have proper sleep. Id.
        On October 4, 2010, petitioner saw Dr. Robert A. Wohlman at NW Gastroenterology
Associates with the chief complaint of postprandial hypotension. Med. recs. Ex. 42, at 16.
Petitioner stated that “whenever she eats, within 15 minutes she becomes allergic, dizzy,
diaphoretic, and sweaty.” Id. Petitioner had to have her feet elevated after eating to help control
her symptoms. He described petitioner’s medical condition as “unusual.” Id. Petitioner said she
developed a “huge amount of neuropathy” after having a flu shot several years previously. Id.
Petitioner did not have any anorexia, weight loss, fever, musculoskeletal complaints, or other

67
   SSRI stands for selective serotonin reuptake inhibitor. Dorland’s at 1759.
68
   Postprandial means after a meal. Dorland’s at 1502.
69
   Diaphoresis is sweating. Dorland’s at 509.

                                                         39
gastrointestinal or systemic complaints. Id. However, under review of systems, Dr. Wohlman
listed petitioner complained of diarrhea, abdominal pain, constipation, nausea, vomiting, and
getting full quickly at meals. Id. at 17. Petitioner’s gait was normal and she could undergo
exercise testing and/or participate in an exercise program. Id. at 18. Petitioner’s memory was
intact for recent and remote events. Dr. Wohlman’s assessment was that petitioner had
autonomic dysfunction manifested especially postprandially. Id.
       On October 28, 2010, petitioner saw Dr. Cintron, her neurologist. Med. recs. Ex. 1, at 2.
Her voice and walking were better. Her problem continued to be memory and decompensating
when she tried to work hard cognitively. In addition, she had fainting episodes when she ate. Id.
         On December 15, 2010, petitioner saw Dr. Daniel V. Wilkinson Jr., a cardiologist at
Swedish Medical Center. Med. recs. Ex. 12, at 3. Under history of present illness, he wrote
petitioner had a very unfortunate history of a profound immunologic reaction to a flu shot,
resulting in autonomic dysfunction which she characterized as POTS. She responded reasonably
well to Norpace. She subsequently developed profound postprandial hypotension. She
manifested virtual collapse with loss of speech and was placed on Sandostatin70 intramuscularly,
causing “a dramatic improvement.” Id. Petitioner was extremely heat intolerant and reported
that if she walked into a heated building, her blood pressure would drop and she would become
presyncopal. She did not have a history of palpitations. Id.
        On January 14, 2011, petitioner saw Dr. Cintron, who noted that petitioner was able to
walk better, run better, and tolerate food significantly better. Med. recs. Ex. 1, at 1. Dr. Cintron
stated the biggest cognitive problem petitioner still had was speaking in her accent which was
more prominent, and cognitive function when she was in a hot temperature and standing,
compared to when she was lying down. Id.
         On February 3, 2011, Dr. Cintron wrote a medical summary. Med. recs. Ex. 26, at 1. He
states, “In summary, her medical and neurological situation has been at best confusing and very
difficult to intellectually define.” Id. He concludes that her main physiological pathology
involved her autonomic nervous system and regulation of cerebral blood flow, resulting in
extreme sensitivity to collapse and fainting for which she tried to compensate by exercising
“almost to a pathological amount” and taking medications to augment vasomotor tone. Id.
Because of ongoing cerebral hypoperfusion, she developed cognitive processes and issues which
fluctuated and changed her intonation. Dr. Cintron states, “I don’t know if these particular
problems are related to the initial insult, versus ongoing cerebral hypoperfusion. All of this is in
my opinion is casually [sic] related to her flu vaccination, which is not unknown to cause post-

70
   Sandostatin is “trademark for preparations of octreotide acetate.” Dorland’s at 1667. Octreotide is “an eight-
amino acid synthetic analogue of somatostatin, having actions similar to those of somatostatin but having a
prolonged duration of effect.” Id. at 1312. Octreotide acetate is “the acetate salt of octreotide, used as a treatment
adjunct for the palliative treatment of diarrhea associated with gastrointestinal endocrine tumors.” Id. Somatostatin
is “any of several cyclic tetradecapeptides elaborated primarily by the median eminence of the hypothalamus and by
the delta cells of the pancreatic islets; they inhibit release of growth hormone, thyrotropin, and corticotropin by the
adenohypophysis, of insulin and glucagon by the pancreas, of gastrin by the gastric mucosa, of secretin by the
intestinal mucosa, and of renin by the kidney.” Id. at 1735.

                                                          40
vaccination neuropathies, which can present with autonomic instability.” Id. He goes on to state
that petitioner is not able to be gainfully employed and is totally disabled. Id.
        On February 3, 2011, petitioner saw Dr. Wilkinson. Med. recs. Ex. 12, at 1. Petitioner
continued to deal with abnormal neurovascular activity with symptomatic hypotension. She was
taking very potent medications. She had multiple “very unusual symptoms” including changes
in her speech and language patterns associated with presumed drop in blood pressure. Her
exercise tolerance was poor. She stated walking up two flights of stairs caused her to lose her
speech and become presyncopal. She started taking midodrine,71 but it was difficult to know if
she had a significant response. She also took disopyramide72 and gabapentin. She took
Sandostatin which apparently allowed her to eat reasonably. She denied palpitations. She did
not have unusual syncope. She was frequently presyncopal presumably on an orthostatic basis.
She said she had episodic chest pain which totally went away with exercise and she felt best
when exercising vigorously. Id. Dr. Wilkinson’s impression was that petitioner had severe
vasodepressive syndrome, “apparently following viral syndrome,” and “unusual manifestations”
of hypotension which in addition to presyncope included change of voice and dialect. Id. at 2.
       On February 15, 2011, petitioner wore a Holter monitor73 for 23 hours and 55 minutes
because of syncope and collapse. Id. at 5. Petitioner reported symptoms of shortness of breath
and chest pain, but the monitor showed they were clearly not related to arrhythmia. Id.
        On July 29, 2011, petitioner was evaluated by Dr. Blair Grubb at the Cardiac
Electrophysiology and Autonomic Function Clinic at the University of Toledo Medical Center.
Med. recs. Ex. 38, at 1. Dr. Grubb writes petitioner developed POTS because of flu vaccination.
Dr. Grubb was under the impression that petitioner received flu vaccine on September 3, 2009,
rather than the actual date which was August 23, 2009. Therefore, his statement that “shortly
thereafter” (i.e., shortly after the vaccination), petitioner began to experience muscle weakness,
fatigue, and exercise intolerance as well as POTS is inaccurate. Petitioner continued to
misinform Dr. Grubb because he notes petitioner was diagnosed with GBS as a consequence of
vaccination.74 Id. On physical examination, petitioner’s supine blood pressure was 148/78 and
her upright blood pressure was 148/84. Her pulse in both supine and upright positions was 79.
Id. To Dr. Grubb, “it sounds as though she has developed an autonomic neuropathy” as the
result of a reaction to the vaccination. Id. at 1-2. Dr. Grubb stated that he had “personally seen
this on several occasions previously” and “in most cases of postural tachycardia syndrome in
adults, they were well either until a viral infection or similar immunologic stimulus caused them
to produce autoantibodies against peripheral acetylcholine receptors in the sympathetic and
parasympathetic system.” Id. at 2. Dr. Grubb suggested adding pyridostigmine (Mestinon) to

71
   Midodrine hydrochloride is “a direct-acting sympathomimetic agent, which stimulates the ɑ-adrenergic receptors
of the arteriolar and venous vasculature; used as a vasopressor in the treatment of orthostatic hypotension.”
Dorland’s at 1165. A vasopressor stimulates “contraction of the muscular tissue of the capillaries and arteries.” Id.
at 2027.
72
   Norpace. See supra, n.58.
73
   A Holter monitor is a type of ambulatory EKG. Dorland’s at 1175.
74
   Petitioner’s history to Dr. Grubb and his reliance on it are inconsistent with petitioner’s medical records where her
treating doctors ruled out GBS. Med. recs. Ex. 44, at 17.

                                                          41
petitioner’s medical treatment of Neurontin, Norpace, midodrine, and octreotide. While noting
Mestinon was initially used to treat myasthenia gravis, its use has extended to autonomic nervous
system disease. For petitioner’s cognitive impairment, he prescribed Cerefolin NAC. He
described it as a modified form of folic acid frequently used to treat cognitive impairment
associated with chemotherapy. Dr. Grubb spent two and one-half hours with petitioner. Id.
        On August 12, 2011, petitioner had a single-photon emission computed tomography
(“SPECT”) brain scan at Cedars-Sinai Medical Center that Dr. Kelly E. Williams, petitioner’s
new PCP, requested. Med. recs. Ex. 39, at 2-3; Ex. 52, at 5-6; Ex. 54, at 13. According to the
report, Dr. Alan D. Waxman noted marked reduction in perfusion of the watershed75 areas of the
frontal lobes extending to the posterior brain and a decrease in perfusion in the right thalamus
when compared to the left. Med. recs. Ex. 39, at 2, and Ex. 54, at 13. The periventricular white
matter/ventricular regions were within normal limits. There was a slight but definite decrease in
the right cerebellum when compared to the left. Dr. Waxman’s impression was that the findings
were consistent with a vascular process, mainly impacting the small vessels and, to some extent,
branches of the right middle cerebral artery and left posterior cerebellar artery. Dr. Waxman
stated these findings were highly associated with systemic lupus or other autoimmune processes,
including antiphospholipid antibody syndrome. Id. Lyme disease was a consideration as well.
Med. recs. Ex. 39, at 3.
        However, petitioner’s laboratory testing for antiphospholipid antibodies, C-reactive
protein, Cyclic Citrullinated Peptide (“CCP”) antibody, and ANA choice Cascade antibody were
all normal. Med. recs. Ex. 41, at 1-5, and Ex. 42, at 30-37. A handwritten note on the laboratory
test report stated “. . . blood tests all normal. No evidence of autoimmune disease.” Med. recs.
Ex. 42, at 30. The filing of Exhibit 42 lists more blood tests than the filing of Exhibit 41
although they both reflect testing done on August 31, 2011 with reports issued on September 6,
2011. Exhibit 42 includes petitioner’s negative testing for not only phosphatidylserine
antibodies, but also cardiolipin antibodies, IgG, IgM, and IgA. Med. recs. Ex. 42, at 31.
        On November 2, 2011, petitioner saw Dr. Elmer Y. Chang, a gastroenterologist, in
Mission Viejo, California, upon Dr. Williams’ referral for an evaluation for postprandial
hypotension. Med. recs. Ex. 114, at 1. In August 2010, petitioner went to UCLA for an upper
endoscopy, CT scan of her abdomen and pelvis, esophageal manometry, and a gastric emptying
study, all of which were reportedly normal. Id. at 2. She was diagnosed with postprandial
hypotension secondary to autonomic dysfunction. Id. She was started on octreotide with
dramatic improvement of her symptoms. Id. at 2-3. Since then, she had not had any further GI
symptoms. Id. at 3. Dr. Chang found petitioner’s vitals and physical examination unremarkable.
His impression was:
                 This is a very unusual case of postprandial hypotension. Normally,
                 one would expect [a] slight decrease in systemic blood pressure
                 following meals due to increased splanchnic blood flow.

75
  Watershed is “an area where the peripheries of two vascular beds meet, particularly in the brain.” Dorland’s at
2076.

                                                         42
                  However, because of her autonomic dysreflexia, she develops an
                  exaggerated blood pressure response. The reason why octreotide
                  may work for her is that it decreases splanchnic blood flow,
                  thereby increasing systemic blood pressure. Obviously, large
                  meals would also increase splanchnic blood flow and should be
                  avoided.
Id. Dr. Chang recommended petitioner continue with octreotide, which his clinic would
administer to her. In addition, she should eat small meals multiple times a day instead of large
meals so as to decrease the chance of postprandial hypotension. Id.
        On December 8, 2011, petitioner saw Dr. Mariko L. Ishimori, a rheumatologist, at
Cedars-Sinai Medical Center, for an assessment of her abnormal SPECT scan and concern for a
possible central nervous system vasculitis. Med. recs. Ex. 54, at 4. Petitioner told Dr. Ishimori
that she had had a severe and unusual reaction to flu vaccination resulting in an autoimmune
reaction two years previously. It started with postprandial hypotension and progressed to
orthostatic hypotension which required hospitalization. Within the first few days of
hospitalization, she developed rhabdomyolysis with CPK peaking at 13,000. She said all these
symptoms progressed and accelerated over one week, escalating over a two-month period during
which she was hospitalized consistently at Inova Fairfax Hospital. Id.
        Serologic testing resulted in a negative result for an extensive panel of antiphospholipid
antibodies. Petitioner’s ANA was negative as well. Petitioner stated that she had only one
positive ANA test during her acute hospitalization, and the highest was 1:80. Id. Dr. Ishimori
ordered ANA testing on December 8, 2011. Med. recs. Ex. 57, at 1. Two results are listed:
1:320 (speckled pattern) and 1:40 (homogeneous pattern). Petitioner tested negative for the
following: anti-centromere antibody, anti-SCL-70 antibody, anti-Sm antibody, anti-RNP
antibody, anti-RO antibody, anti-LA antibody, anti-DS DNA antibody, and anti-chromatin
antibody. Anti-DS DNA antibody tested 3.0 when normal is less than 7.0. Petitioner’s
complement C3 tested at 110 when normal is between 79 and 152 mg/dL. Petitioner’s
complement C4 tested at 25 when normal is between 16 and 49 mg/dL. Petitioner tested
negative to cardiolipin, IgG, IgA, and IgM. She tested negative to citrulline, rheumatoid factor,
and thyroid microsomal P antibody. Id.
        Petitioner said she tried to exercise 20 hours per week by running, cycling, and
weightlifting. Id. at 5. She did not have a problem with sleep. Petitioner said she had an allergy
to lidocaine,76 Carbocaine,77 Ativan, Zoloft,78 Klonopin, transdermal Scopolamine patch,
Benadryl,79 and NyQuil, all of which resulted in heart palpitations, slurred speech, fainting, and

76
   Lidocaine is “a drug having anesthetic, sedative, analgesic, anticonvulsant, and cardiac depressant activities, used
as a local anesthetic.” Dorland’s at 1034.
77
   Carbocaine is “trademark for preparations of mepivacaine hydrochloride.” Dorland’s at 288. Mepivacaine
hydrochloride is “a local anesthetic, an analogue of lidocaine.” Id. at 1136.
78
   Zoloft is “trademark for preparations of sertraline hydrochloride.” Dorland’s at 2092. Sertraline hydrochloride is
“a selective serotonin reuptake inhibitor, used to treat depressive, obsessive-compulsive, and panic disorders.” Id. at
1699.
79
   Benadryl is “trademark for preparations of diphenhydramine hydrochloride.” Dorland’s at 208.

                                                          43
difficulty breathing. Id. Dr. Ishimori did a review of systems. Petitioner had fatigue, weakness,
pain, ringing in her ears, and dry mouth. Id. She claimed irregular heart beat and chest pains.
Id. at 6. She had occasional shortness of breath and difficulty breathing at night. She had nausea
and recurrent diarrhea. She had morning sickness lasting one hour, and joint pain involving her
hands and feet. She had headaches, dizziness, fainting, muscle spasm, loss of consciousness,
memory loss, and night sweats, all related to orthostatic hypotension. She had excessive thirst.
Id.
        On physical examination, petitioner had a blood pressure of 122/79. She was well-
nourished. She did not have synovitis in the MCP,80 PIP,81 or DIP82 joints. Her hands had full
range of motion. She did not have evidence of tenderness over the extensor tendons and no
evidence of tenosynovitis or erythema on the dorsum of her hands. She did not have warmth,
swelling, or tenderness to palpation. She had full range of motion. Her ulnar nerve when
examined led to significant tremor. She had no evidence of vascular changes. Her strength was
intact bilaterally and symmetrically in the upper and lower extremities. She did not have
evidence of muscle weakness. She had good strength, 5/5 symmetrically. Id.
        Petitioner showed Dr. Ishimori the results of her lab tests done August 31, 2011. Id. at 7.
Her antiphospholipid antibody panel was negative, as were antibody IgG, IgA, C-reactive
protein, CCP antibody, ANA, and a complete metabolic panel. Dr. Ishimori discussed with
petitioner that there was no clear-cut evidence based on her examination or history that she
actually had lupus or a phospholipid antibody syndrome. Id. As far as her abnormal brain
SPECT was concerned, Dr. Ishimori wrote “it is interesting to note that she had a normal MRI
and MRA.” Id. Although the SPECT scan was reported to be associated with some cognitive
function and central nervous system lupus, Dr. Ishimori believed there were other potential
etiologies and explanations, particularly in a patient with a very unusual history of a very severe
orthostatic dysfunction, which may lead to poor episodic perfusion of specific areas of the brain,
which might be related to her poor previous control of orthostatic hypotension. Id.
       Dr. Ishimori recommended petitioner see Dr. Patrick D. Lyden, the chairman of
neurology at Cedars-Sinai Medical Center. Id. Dr. Ishimori wrote:
                  I think based on her examination I see no evidence of a peripheral
                  autoimmune or connective tissue disorder that would explain a
                  SPECT that would be vasculitic in nature, and I do not think that
                  this result necessarily correlates with a vasculitis in this patient. In
                  addition, I do not think this is a primary central nervous system
                  vasculitic process as she is not in a typical group, and given her
                  history of orthostatic hypotension . . . . I also discussed with the
                  patient that in young women, … there are other conditions such as

Diphenhydramine is “a potent antihistamine (H1 receptor antagonist) with anticholinergic, antitussive, antiemetic,
antivertigo, antidyskinetic, and sedative actions.” Id. at 523.
80
   MCP stands for “metacarpophalangeal.” Med. Abbrev. at 221.
81
   PIP stands for “proximal interphalangeal.” Med. Abbrev. at 282.
82
   DIP stands for “distal interphalangeal.” Med. Abbrev. at 115.

                                                         44
                 benign angiopathy that can occur, which are associated with more
                 vasoreactivity than necessarily vascular inflammation, which can
                 be mimics for vasculitic pictures. I think in her case most likely
                 these abnormalities represent her perfusion related issues and not a
                 true inflammatory vasculitic process.
Id.
        On January 10, 2012, petitioner saw Dr. Patrick D. Lyden, chairman of neurology at
Cedars-Sinai Medical Center. Med. recs. Ex. 54, at 9. Dr. Lyden did a physical examination and
wrote petitioner was alert and fluent and had good recall. On looking to the right, petitioner had
a few beats of rotary nystagmus, fast component. Id. On motor examination, she had normal
bulk, power, and tone throughout. Id. at 10. On sensory examination, she was intact to light
touch, pinprick, double simultaneous stimulation, and position sense. Her reflexes were
markedly suppressed throughout with slight asymmetry, being more depressed on the right than
on the left. Her finger-nose-finger coordination was normal. She had some functional
component and stimulated tremor, but no deficit. Heel-shin was normal. Romberg83 was
negative. Heel-toe walking was normal. Id.
        Dr. Lyden’s impression was that:
                 This is a very complicated case. I believe we need to assemble more
                 data to be sure. Taking everything at face value, it sounds as though
                 she did have an illness that has left her with a severe dysautonomia.
                 In addition, I believe she has migraine as evidenced by the
                 intolerance of bright lights, loud sounds and a history of migraines.
                 A lot of her headache and nausea in response to bright lights could
                 be migraine related. The dysautonomia has been documented and
                 could be an exaggeration of normal vagal hypersensitivity. In
                 addition, I believe there is an unsuspected psychiatric diagnosis, but
                 it is too soon to be sure that this is real. She does have some trace
                 neurologic findings that would localize to the right cerebellum or
                 brainstem, given the rotary nystagmus and hypotonia. I would like
                 to review her MRI scan.
                 She will return next visit with MRI scans from Johns Hopkins and
                 UCLA. We will perform a transcranial duplex to try to recreate the
                 small-vessel disease seen on SPECT scan. I will review her medical
                 workup at that time.
Id. at 10.
        On January 13, 2012, petitioner returned to Dr. Lyden and had a transcranial doppler to
see if she had small vessel vasculitis. Id. at 11, 12. Velocities and resistances were obtained at

83
  The Romberg sign is “swaying of the body or falling when standing with the feet close together and the eyes
closed; the result of loss of joint position sense.” Dorland’s at 1715.

                                                        45
multiple depths from the middle cerebral, anterior cerebral, and posterior cerebral arteries. Id. at
11. In addition, the ophthalmic, vertebral, and basilar arteries, and extracranial internal carotid
arteries were imaged. All of petitioner’s waveforms were normal. Her velocities were slightly
elevated, especially at depth. For example, at 51mm in the right middle cerebral artery, the
pulsatility index was 1.34 and, on the left, 1.13. Dr. Lyden’s impression was that petitioner’s
study was normal. However, the pulsatility indices trended toward the high side, indicating
possible small vessel involvement. Id. His clinical impression was that, taken in the context of
petitioner’s other findings, the result of the transcranial doppler could indicate a normal state.
However, petitioner could also have distal compression of the smallest vessels in her brain. Id.
        On January 13, 2012, petitioner resumed her visit with Dr. Lyden. Id. at 12. Petitioner
told Dr. Lyden she did not have any change in her symptomatology. She brought a series of
medical records which Dr. Lyden reviewed. Petitioner’s tilt test was negative for hypotension.
During the tilt test, she had acute onset of dysarthria and dystonic posturing. Her multiple MRI
scans were normal. Cardiologists treated her possible dysautonomia with Norpace. The medical
records did not support any evidence of GBS. The medical records did not support any evidence
of hypotension. Dr. Lyden notes the medical records repeatedly described petitioner’s “bizarre
and unusual symptoms related to postural changes.” Id. He noted petitioner had a significant
dystonic and syncopal reaction during a carotid ultrasound. Id.
        On physical examination, petitioner’s mental status was “again remarkable” for a
significant indifference to her medical state. Id. She spoke in a foreign accent for approximately
half of the visit. This resolved spontaneously and she finished the visit with her Midwestern
American accent. Id. There was no change in her cranial nerve exam, her motor or sensory
function, or her reflexes. Dr. Lyden’s impression was that her transcranial doppler study was
essentially normal but did have resistance indices trending toward the high side. After reviewing
petitioner’s medical records and her examination, Dr. Lyden stated he clearly saw that she had a
number of symptoms that were “embellished;” however, she did have an acute reaction
characterized by rhabdomyolysis during a dehydrational episode. Id. She also had symptoms
that were suggestive of dysautonomia despite the negative tilt table test. Dr. Lyden believed
petitioner needed a good psychologic evaluation, referring her to Dr. Ellen Basian. Id.
       Dr. Lyden noted petitioner had a history of empty sella84 on imaging, which he thought
was probably benign, but recommended pituitary function testing. Dr. Lyden said there was an
extremely remote possibility that petitioner could have acute intermittent porphyria.85 That
would explain the bulk of her symptoms, including the rhabdomyolysis. Petitioner was not at the
time symptomatic, but nevertheless, he would send her for a baseline urine porphyrin and
porphobilinogen86 and see her in follow up after she saw Dr. Basian, the psychologist. Id.

84
   Sella is “a saddle-shaped depression.” Dorland’s at 1689.
85
   Porphyria is “any of a group of disturbances of porphyrin metabolism, characterized biochemically by marked
increase in formation and excretion of porphyrins or their precursors and clinically by various neurologic and
cutaneous manifestations.” Dorland’s at 1497.
86
   Porphobilinogen is “the immediate precursor of the porphyrins.” Dorland’s at 1497.

                                                       46
        On February 29, 2012, petitioner saw Dr. Michael J. Olek, osteopath, at Newport Doctors
Multiple Sclerosis Clinic. Med. recs. Ex. 61, at 1. Petitioner gave a history that the onset of her
symptoms was August 23, 2009, the day of her flu vaccination. Id. Dr. Olek did not have
petitioner’s medical records. Petitioner complained that in January 2012, her extreme fatigue
worsened. Id. Petitioner complained of blurry vision, eye pain, snoring, ringing in the ears,
earache, chest pain, fainting, shortness of breath, nausea, vomiting, frequent urination, nighttime
urination, sleepiness, headache, dizziness, numbness, fatigue, hot and cold intolerance, and joint
pain. Id. at 3. Although petitioner complained to Dr. Olek that she was allergic to Lidocaine,
Carbocaine, Zoloft, Ativan, Klonopin, transdermal Scopolamine patch, Benadryl, and Nyquil, he
thought that most of these were just bad reactions, rather than allergies. Id. Petitioner was
divorced and lived alone. She drank seven cups of coffee a day. Id.
        On physical examination, petitioner had occasional slurred speech and foreign accent. Id.
at 4. Her motor strength was 5 out of 5 with normal tone and bulk. Her deep tendon reflexes
were +2 and equal. Her toes were downgoing. Coordination showed normal finger-to-nose-
finger, rapid alternating movement, and heel-to-shin. Sensory exam was intact to light touch,
pinprick, vibration, proprioception, and temperature. She was able to walk 25 feet in six seconds
with a normal gait. Her tandem walk was normal. The Romberg was negative. Petitioner could
hop independently on each foot. Dr. Olek’s wrote his impression, “At this time, it is difficult to
have a unifying diagnosis.” Id. He felt petitioner had some symptoms of lupus and autoimmune
dysautonomia. He planned to have her undergo a spinal tap to look for signs of MS. In
December 2011, she had an ANA positive at 1:320 in a speckled pattern. Id.
        On March 13, 2012, petitioner saw Dr. Chang for a follow-up visit. Med. recs. Ex. 114,
at 4. Petitioner reported that she had more trouble with bloating with wheat products, but the
trouble stopped when she stopped eating wheat products. Id. Dr. Chang ordered labs as well as
recommended a trial of probiotics. Id. Noted on petitioner’s pathology report, collected on
March 20, 2012, was the recommendation that petitioner should proceed with a gastric emptying
study. Id. at 6. A pathology report dated March 20, 2012 showed mild inflammation of
petitioner’s esophagus consistent with acid reflux. Id.
         On March 28, 2012, petitioner saw Dr. Olek, complaining of left foot drop. Med. recs.
Ex. 61, at 5. Petitioner had an MRI of her brain on March 15, 2012 whose result was normal.
Id. at 5. Petitioner told Dr. Olek that two years previously, she underwent hyperbaric oxygen for
one to two hours a day “prescribed by her neurologist” [Dr. Buttar is an osteopath, not a
neurologist]. Id. She said it was helpful, but she stopped in December and related that, since
January, she had been having increasing problems. Petitioner had a lumbar puncture. Her IgG
index was normal at 0.52, and she did not have oligoclonal banding. Id.
        Petitioner saw Dr. Swaraj Bose,87 a neuro-ophthalmologist at University of California,
Irvine, on February 22, 2012 and March 21, 2012. Dr. Olek had Dr. Bose’s records. Dr. Bose’s

87
  Petitioner did not file Dr. Bose’s records. At the time petitioner saw him, Dr. Bose was Associate Professor of
Ophthalmology and Neurology, a board-certified ophthalmologist, and Director of Neuro-ophthalmology and orbital
surgery at the University of California, Irvine. He specializes in the medical and surgical management of patients
with diseases of the eye in relation to the brain. His interests include optic neuropathies including MS, cranial nerve

                                                          47
records showed petitioner’s visual acuity was normal at 20/20, and her color vision was normal
at 8 out of 8 bilaterally. Her confrontational fields were normal. Id. Petitioner told Dr. Olek
that Dr. Bose diagnosed her with optic neuritis, but Dr. Olek did not find that diagnosis in Dr.
Bose’s medical records. Id. at 5-6. In petitioner’s visit to Dr. Bose on March 21, 2012, Dr. Bose
wrote petitioner’s eye exam was totally normal. Id. at 6.
        During a physical and neurologic examination, Dr. Olek observed that petitioner was
awake, alert, and oriented with fluent speech. Her visual fields were full. Motor strength was 5
out of 5 throughout except for her left lower extremity which was 5- out of 5 distally. Her deep
tendon reflexes were +2 and equal. Her coordination was equal except for her left lower
extremity. Her sensory exam was intact throughout. She was able to walk 25 feet in eight
seconds, with a mild left foot drop. Id. Dr. Olek again noted it was difficult to have a unifying
diagnosis; however, he felt petitioner had some symptoms of lupus and autoimmune
dysautonomia. Id. He prescribed a trial of five days of one gram of IV methylprednisolone and
continuation of her medications. He told her to continue with physical therapy. Petitioner said
she was going to buy a hyperbaric oxygen chamber for $7,500 and would start this after her IV
infusion at Hoag Hospital. Id.
        On March 30, 2012, petitioner had a gastric emptying study for abdominal pain. Med.
recs. Ex. 62, at 1. Dr. Sam Kipper wrote petitioner had significant retention of activity within the
gastric fundus and remainder of the stomach. This was very slow gastric emptying. Petitioner’s
half-emptying time was 223 minutes compared to the normal time of between 30 and 90 minutes.
Petitioner emptied 18 percent of the gastric mean by 90 minutes. Dr. Kipper’s impression was
markedly prolonged gastric emptying consistent with gastroparesis.88 Id.
        On April 13, 2012, petitioner had a CT scan of the abdomen and pelvis with and without
contrast. Med. recs. Ex. 114, at 8. The test found the lung bases, liver, spleen, gallbladder,
adrenal glands, pancreas, kidneys, ureters, bladder, uterus, adnexa,89 abdomen, and pelvis were
normal. Id. The test showed that there was mild distention of the gallbladder. Id. Petitioner
then returned to see Dr. Chang on April 16, 2012. Id. at 10-11. Dr. Chang recommended
petitioner continue her medications, eat small meals, and return in three months.90 Id. at 11.
        On April 16, 2012, petitioner saw Dr. Chang. Med. recs. Ex. 114, at 10. Her
postprandial nausea and bloating improved with octreotide. Reglan91 also helped. She had
epigastric pain whenever she overate. Id.

palsies, ocular myopathies including myasthenia gravis, thyroid eye disease, pseudotumor cerebri, and eyelid/orbital
tumors. Swaraj Bose, UCI FACULTY PROFILE SYSTEM, https://www.faculty.uci.edu/profile.cfm?faculty_id=4861
(last visited Mar. 6, 2019).
88
   Gastroparesis is “paralysis of the stomach, usually from damage to its nerve supply, so that food empties out much
more slowly, if at all. Symptoms include postprandial bloating and vomiting, and often hypoglycemia because of
food not moving properly into the duodenum.” Dorland’s at 765.
89
   Adnexa are appendages. Dorland’s at 32.
90
   Petitioner subsequently visited Dr. Chang for follow-up appointments to manage her gastroparesis and
postprandial hypotension on May 29, 2012, April 9, 2013, and August 28, 2013. Med. recs. Ex. 114, at 12-16.
91
   Reglan is “trademark for preparations of metoclopramide hydrochloride.” Dorland’s at 1621. Metoclopramide
hydrochloride is “a prokinetic dopamine receptor antagonist that stimulates gastric motility, used as an antiemetic,

                                                         48
        On April 18, 2012, petitioner saw Dr. Daniel J. Wallace, an internist and rheumatologist
in West Hollywood, CA, to rule out autoimmune disease. Med. recs. Ex. 60, at 8, and Ex. 112,
at 1. He noted petitioner had an extremely complicated and detailed medical history. Id.
Porphyria workup was negative. Id. Petitioner told him that a neuro-ophthalmologist told her
she has optic neuritis but the doctor’s notes do not mention it. On physical examination, she had
a scanning speech pattern that changed into different foreign accents as the exam progressed.
She was cushingoid.92 Her carotid arteries were exquisitely sensitive to touch. Minimal
Raynaud’s was present. Her neurologic exam was intact. Id. Dr. Wallace’s impression was that
petitioner suffered from post-vaccination syndrome characterized by rhabdomyolysis and
orthostatic hypotension in somebody with a strong family history for rheumatic disease. Med.
recs. Ex. 60 at 9; Ex. 112, at 2. Dr. Wallace stated that petitioner may have a metabolic or
mitochondrial myopathy that needed to be further explored. Id. He wrote, “I personally think
she has ‘Raynaud’s of the brain’93 with severe dysautonomia.” Id.

… and in the treatment of gastroparesis and gastroesophageal reflux.” Id. at 1154.
92
   Cushingoid means “resembling the features, symptoms, and signs associated with Cushing syndrome.” Dorland’s
at 450. Cushing syndrome is “a complex of symptoms caused by hyperadrenocorticism due either to a neoplasm of
the adrenal cortex or adenohypophysis, or to excessive intake of glucocorticoids. Symptoms may include adiposity
of the face, neck, and trunk; kyphosis from osteoporosis of the spine; hypertension; diabetes mellitus; amenorrhea
and hypertrichosis in females; … dusky complexion with purple striae; polycythemia; and muscular wasting and
weakness. When secondary to excessive pituitary secretion of corticotropin, it is known as Cushing disease.” Id. at
1827.
93
   Dr. Wallace wrote a letter in response to an article by Efrosini Papadaki et al., Neuropsychiatric Lupus or not?
Cerebral Hypoperfusion by Perfusion-Weighted MRI in Normal-Appearing White Matter in Primary
Neuropsychiatric Lupus Erythematosus, 77 ANN RHEUM DIS 441 (2018). David J. Wallace, Correspondence, 78
ANN RHEUM DIS e5 (2019). Dr. Wallace writes he read with interest the Papadaki article but believes the authors
come to the wrong conclusion, firstly because they rely on definitions Dr. Wallace and others used in a 1999 article
to define neuropsychiatric lupus syndromes, which Dr. Wallace now says are outdated and not evidence based. He
cites to ACR Ad Hoc Committee on Neuropsychiatric Lupus Nomenclature, The American College of
Rheumatology Nomenclature and Case Definitions for Neuropsychiatric Lupus Syndromes, 42 ARTHRITIS RHEUM
599 (1999). Dr. Wallace states in his correspondence related to the Papadaki article that the best objective measure
for a central nervous system inflammatory process is a lumbar puncture. Dr. Wallace states that pleocytosis,
increased protein levels, increased IgG synthesis rates, oligoclonal bands or antineuronal antibodies are the only
objective metrics that can make the diagnosis of neuropsychiatric lupus outside a brain biopsy or obvious
neuroimaging abnormalities. But none of the patients in Papadaki’s articles had a spinal tap. Secondly, he criticizes
Papadaki for not realizing that others before him, including Dr. Wallace’s group, demonstrated that most lupus
patients with neuropsychiatric lupus had SPECT imaging abnormalities consistent with hypoperfusion in the
watershed regions. He cites to an article in which he is a co-author: Catherine B. Driver et al., Clinical Validation of
the Watershed Sign as a Marker for Neuropsychiatric Systemic Lupus Erythematosus, 59 ARTHRITIS RHEUM 332
(2008). Dr. Wallace states in his correspondence, “In other words, most patients had vasomotor instability on an
autonomic basis (‘Raynaud’s of the brain’) in, for example, the frontal-parietal interface where the vasculature is
very small, numerous and prone to spasm. While some of these patients have an inflammatory process, the majority
develop ‘lupus fog’ as a consequence of intermittent hypoperfusion. This should not be considered to be
neuropsychiatric lupus and is managed with cognitive behavioural [sic] therapy, anxiety reduction measures,
biofeedback and approaches that target the dysautonomia of lupus.” Dr. Wallace cites to Ljudmila Stojanovich,
Autonomic Dysfunction in Autoimmune Rheumatic Disease, 8 AUTOIMMUN REV 569 (2009). Dr. Wallace also used
the expression “Raynaud’s of the brain” in an interview for a blog that one of his colleagues calls Attune Health.
Dr. Wallace used the expression in relation to lupus patients complaining of a mental fog or difficulty thinking
clearly. He explains that the sympathetic nervous system (part of the autonomic nervous system) controls opening
and closing blood vessels. When it is cold, the patient’s Raynaud’s constricts the blood vessels. When it is warm,
the blood vessels can over dilate and turn red. Dr. Wallace said the same phenomenon can occur in the brain. When

                                                          49
        On May 17, 2012, Dr. Williams referred petitioner to Dr. Joey R. Gee, an osteopath at
Mission Internal Medical Group in Mission Viejo, California, for consultation. Med. recs. Ex.
115, at 1. Petitioner complained about daily headache and sharp pains in her right eye. Id.
Petitioner told Dr. Gee that she had optic neuritis in both eyes (there has never been a diagnosis
of optic neuritis in petitioner; Dr. Gee did not have her neuro-ophthalmologist records to know
that she did not have optic neuritis). Pyridostigmine was prescribed for possible myasthenia
gravis but it did not help. Yet petitioner seemed to control her breathing problem, and weakness
in her foot and voice. She reported a brain SPECT suggested vascular changes indicating small
vessel vasculopathy, with impairment of the cerebellum, right thalamus, and bilateral watershed
zones. Since January, petitioner had been declining, but her speech and drop foot were better.
Id.
        On physical examination, petitioner had normal range of motion in all four extremities.
Her memory was intact. She had normal 5 out of 5 strength in her upper and lower extremities
although she might have some fatiguing of the proximal muscles of the arms and hips. Id. at 4.
Her reflexes were 2+ with absent frontal release signs. Id. Petitioner had normal tone, no
spasticity, and normal sensation in the extremities. Id. at 5. Her balance was stable with her feet
together and her eyes closed. Her gait was intact with tandem. Her balance was normal. She
did not have any language deficits and had a normal attention span and concentration. Id.
        Dr. Gee noted that petitioner presented with a myriad of symptoms, the underlying
diagnosis was still an “enigma,” and she had yet to present with a distinct primary diagnosis. Id.
Petitioner had gross syndromes for the most part, “characterized by all the systemic complaints,
ranging through a number of systems” of her body, i.e., rheumatological, cardiovascular,
neurological, cognitive, orthopedic, ophthalmological, and gastrointestinal “to name a few.” Id.
Concerning the diagnosis of myasthenia gravis, Dr. Gee said it was difficult to include all her
system complaints in that diagnosis. Dr. Gee thought lupus might encompass all these systemic
complaints, but a rheumatologist did not give her a specific diagnosis. Id.
        On May 29, 2012, petitioner saw Dr. Chang, the gastroenterologist. Med. recs. Ex. 114,
at 12. She tried Domperidone,94 which caused weakness and fatigue. Reglan seemed to help.
Petitioner said when she runs, her gastroparesis improves. Petitioner was on Sandostatin LAR
for postprandial hypotension. Dr. Chang put a question mark in his records as to whether
petitioner’s postprandial hypotension was secondary to autonomic dysfunction on his March 13,
2012 and May 29, 2012 records. Med. recs Ex. 114, at 4, 12.
        On June 1, 2012, petitioner saw Dr. Gee, complaining of numbness and weakness. Med.
recs. Ex. 115, at 8, 10. Petitioner underwent electromyography (“EMG”) and nerve conduction
studies (“NCS”). The impression was there was no electrodiagnostic evidence for diagnosing a

the vessels overdilate, they cause a headache. When they overconstrict, they cause a mental fog. Dr. Wallace
remarks, “I like to call it ‘Raynaud’s of the brain.’” Rheumatology. Getting Lost in the Brain Fog, THE PURSUIT OF
BETTER, THE BLOG OF ATTUNE HEALTH, https://attunehealth.com/getting-lost-brain-fog/ (last visited Feb. 1, 2019).
94
   Domperiodone is “an antiemetic and prokinetic agent; its actions are related to its peripheral dopamine receptor-
blocking properties. It is used in the treatment of upper gastrointestinal motility disorders caused by chronic and
subacute gastritis and diabetes and the prophylaxis of gastrointestinal symptoms caused by dopamine agonists used
to treat parkinsonism.” Dorland’s at 562.

                                                         50
neuromuscular process. Id. at 10. Repetitive stimulation of one isolated nerve did not reflect a
decremental response which one would expect if petitioner had myasthenia gravis. Petitioner
had stopped taking pyridostigmine for the testing. Id.
        On July 18, 2012, petitioner visited Dr. Gee, complaining of gastroparesis and heart rate
issues. She still complained of myasthenia gravis. Id. at 13. Dr. Gee told petitioner, “I
counseled it is less clear as to the exact nature of her illness given neurological tests are
unremarkable.” Id. Petitioner appeared well on physical examination with no dizziness, no focal
weakness, no gait disturbance, no memory impairment, and no paresthesia. Id. at 15. She did
not have any language deficits. Id. at 16. Her knowledge was intact and she had normal
attention span and concentration. Her cerebral angiogram was normal. Id.
        On March 1, 2013, Dr. Williams filled out an evaluation report for Special Services,
Saddleback College, to enable petitioner to receive disability-related support services. Med.
recs. Ex. 174, at 1. Dr. Williams diagnosed petitioner with autonomic dysfunction. Id. at 2.
        On March 8, 2013, petitioner reported to Dr. Gee, complaining of a cold over the prior
two weeks and feeling weaker with trouble walking. Med. recs. Ex. 115, at 18. On physical
examination, Dr. Gee found that petitioner did not have motor or sensory deficits. Her balance
and gait were intact. Her coordination was intact and her reflexes were preserved at 2+.
However, she had fatiguing weakness of her upper extremities and neck muscles, which caused
spasms of her neck. Id. She did not have language deficits. Id. at 19. She had normal attention
span and concentration. Dr. Gee thought her cold might have mildly exacerbated petitioner’s
myasthenia gravis. He prescribed a small dose of corticosteroid. To help her weakness, she was
to use a smaller dose of pyridostigmine. Id.
       On March 20, 2013, petitioner had a test for acetylcholine receptor binding antibody,
which was negative (<0.30nmol/L), and a test for acetylcholine receptor blocking antibody,
which was negative (<15). Id. at 22, 23. Also on March 20, 2013, petitioner had a test for
MuSK on antibody titer which was negative. Id. at 24. The interpretation states, “This
individual is negative for muscle-specific receptor tyrosine kinase (MuSK) antibodies that are
associated with Myasthenia gravis syndrome (MG).” Id.
       On March 22, 2013, petitioner was retested for acetylcholine receptor binding antibody,
acetylcholine receptor blocking antibody, and MuSK on antibody, all of which were again
negative. Id. at 26, 27, 29. In addition, on that date, petitioner was tested for acetylcholine
receptor modulating antibody, which was negative at 9% (reference range: <32%). Id. at 28.
        On March 26, 2013, petitioner signed a Saddleback College Special Services Educational
Accommodations form, which Connie Jackson, M.S., signed as a faculty member of Special
Services. Med. recs. Ex. 174, at 3. Ms. Jackson noted that petitioner needed to use a laptop for
note-taking and written assignments because handwriting would be too difficult for her due to
mobility issues. Id. Ms. Jackson also authorized petitioner to have use of a room with minimal
distractions and an extension of time to include an additional half-hour increase to accomplish
tasks. Id. at 4.

                                                51
        On April 9, 2013, petitioner saw Dr. Chang. Med. recs. Ex. 114, at 14. Petitioner said
she had daily heartburn in the morning. She had postprandial nausea after breakfast. She was
satiated until dinner time. She also vomited and had anorexia with a 10-pound weight loss since
she last visited. Domperidone did not help her and she had not taken Reglan. Id. Dr. Chang
started petitioner on Protonix95 and restarted her on Reglan. Id.
        On August 13, 2013, petitioner underwent a barium swallow and RAD UGI barium upper
GI exams. Med. recs. Ex. 91, at 1. Dr. Jackson W. Penry wrote petitioner had a normal
swallowing mechanism and no evidence for esophageal obstruction, ulceration, or mucosal mass
lesion. She did not have hiatal hernia or gastric outlet obstruction. She had intermittent partial
obstruction to the forward flow of contrast at the third portion of the duodenum. She did not
have associated mucosal irregularity, external mass lesion, or fold thickening. The findings of
intermittent partial obstruction might represent functional sequelae of external superior
mesenteric artery. Id. Otherwise, this was a normal examination. Id.
        On November 4, 2013, petitioner went to Mission Hospital ED in California with
complaints of shortness of breath and weakness. Med. recs. Ex. 88, at 1. Petitioner told Dr. Raj
Patel that she had a history of myasthenia gravis and autonomic dysfunction consisting of POTS,
gastroparesis, intestinal pseudo-obstruction, and Raynaud’s phenomenon. Her shortness of
breath began on November 2, 2013 at 1:00 a.m. She said she had been sick for two weeks. But
on Friday, her cat and dog fought and were sent to an animal hospital, triggering a flare of her
myasthenia gravis. She woke up Saturday night at 1:00 a.m. with trouble breathing and called
her neurologist Dr. Gee who advised her to come to the ED. Petitioner denied any pain, nausea,
vomiting, chills, fever or dizziness. Id. at 1-2.
        Later the same day, petitioner saw Dr. Loan T. Nguyen. Id. at 4. She told Dr. Nguyen
that she had shortness of breath for the past three days. Dr. Gee recommended IV Mestinon. Id.
Arterial blood gases showed respiratory alkalosis consistent with hyperventilation. Petitioner
was admitted overnight for supportive measures. Id. Petitioner told Dr. Nguyen that she went
on vacation about a week earlier and had a cold after she came back. She reported that she had
not been sleeping well and was undergoing a significant amount of stress at home. She also had
trouble swallowing and obvious stridor.96 Id. Dr. Nguyen’s impression was that petitioner had
myasthenia gravis flare and she was put on BiPAP.97 Id. Petitioner communicated by writing.
Id. at 10.
        On November 5, 2013, petitioner saw Dr. Jagmeet S. Mundi for evaluation of her upper
airway. Id. at 12. Dr. Mundi put a fiberoptic tube down petitioner’s upper airway. Id. at 13.
Petitioner had evidence of significant laryngopharyngeal reflux disease secondary to esophageal
reflux. She had hyperfunction of her true vocal cords including adduction of her vocal cords

95
   Protonix is “trademark for topical preparations of pantoprazole sodium.” Dorland’s at 1537. Pantoprazole
sodium is “a proton pump inhibitor with properties similar to those of omeprazole, used in the treatment of erosive
esophagitis associated with gastroesophageal reflux disease.” Id. at 1371.
96
   Stridor is “a harsh, high-pitched breath sound such as the one often heard on inhalation with an acute laryngeal
obstruction.” Dorland’s at 1785.
97
   BiPAP stands for “bilevel (biphasic) positive airway pressure.” Med. Abbrev. at 65.

                                                         52
during phonation and inspiration, consistent with her history of inspiratory stridor. She did not
have spasming of her vocal cords. The rest of her upper airway evaluation was within normal
limits. Dr. Mundi notes petitioner was seronegative for myasthenia gravis, but there was strong
suspicion for myasthenia, and inspiratory stridor is a known manifestation of myasthenia gravis.
Id.
        On November 7, 2013, petitioner was discharged to home and diagnosed with myasthenia
gravis flare that was improved with IVIG, headache due to IVIG, and stridor related to
myasthenia gravis flare which had resolved. Id. at 6. A CT of petitioner’s chest showed no
evidence of pulmonary embolism, aneurysm, or dissection; her lungs were clear. Id. at 7. On the
day of discharge, petitioner was hemodynamically stable with no complaints. Id.
        On December 2, 2013, petitioner saw Dr. Gee, who describes her as having atypical
myasthenic syndrome, with seronegative biomarkers, but responds to pyridostigmine. Med. recs.
Ex. 115, at 33. Thus far, tertiary care centers Mayo Clinic and UCLA have not determined
another diagnosis. Dr. Gee states that IVIG therapy helped petitioner when she suffered a severe
recent crisis98 of weakness, with symptoms of upper airway stridor, respiratory distress, and
exacerbation of gastroparesis. Id. Dr. Gee ordered Gamunex99 IV solution to be infused every
30 days for six months. Id.
        On February 4 and 5, 2014, petitioner underwent a 24-hour Holter monitor for
palpitations because petitioner complained of dizziness, chest pains, and spots in her vision while
running one mile and lifting weights. Med. recs. Ex. 115, at 36. According to the report,
petitioner’s baseline rhythm was normal, but she had sinus arrhythmia during nocturnal hours.
Id. No arrhythmia was noted during the Holter monitor test and she had normal conduction
intervals in sinus rhythm. Id.
       On March 26, 2014, petitioner saw Dr. Gee again. Id. at 85. Petitioner appeared stable
and showed a positive effect with IVIG. Id. Petitioner’s physical examination was normal. Id.
at 86.
         On March 27, 2014, petitioner saw Dr. Daniel J. Wallace. Med. recs. Ex. 90, at 1.
Petitioner reported that she had abnormal diffuse joint pain and she felt pain in her flank when
she breathed deeply. Id. at 2. Dr. Wallace noted that on April 18, 2012, petitioner had an ANA
titer of 1:160, which he marked as normal, and an ANA speckled pattern, which he also marked
as normal. Id. Petitioner also reported that she had a feeding tube inserted in September 2013,
was receiving IVIG treatment, and was using Mestinon every few hours for her condition. Id.
Petitioner’s autoimmune lab results showed high levels of CO2, AST, and CPK. Id. at 6-7; Ex.
115, at 88-89. Dr. Wallace gave petitioner a neurology referral. Med. recs. Ex. 90, at 5.
       On April 10, 2014, petitioner underwent a stress echocardiogram at Cardiology
Consultants of Newport in Newport Beach, California. Med. recs. Ex. 115, at 90. The result was
normal without evidence for stress-induced myocardial ischemia or dysrhythmia. Id.

98
   Myasthenic crisis is a “sudden development of dyspnea requiring respiratory support in myasthenia gravis; the
crisis is usually transient, lasts several days, and is accompanied by fever.” Dorland’s at 431.
99
   Gamunex is “trademark for a preparation of immune globulin intravenous (human).” Dorland’s at 757.

                                                        53
Petitioner’s baseline echocardiogram showed mitral valve buckling without true prolapse and her
left ventricular systolic function was normal. Id. She had mild mitral regurgitation. Id.
        On April 15, 2014, petitioner had a test of her CPK which was normal. Id. at 91.
       On September 3, 2014, petitioner saw Dr. Gee, reporting she was able to eat and swallow
without bouts of weakness. Id. at 92. She found that the IVIG made a huge difference in her
treatment. Id. Her physical examination was normal. Id. at 93-94.
       On January 9, 2015, petitioner saw Dr. Gee, reporting some intermittent symptoms. Id. at
95. He noted petitioner was struggling. He counseled petitioner about taking Northera,100 a new
drug for autonomic dysfunction. He discussed her concerns over central sleep apnea and
recommended a sleep study. Id. Her physical examination was normal. Id. at 97.
        On January 29, 2015, petitioner saw Dr. Geoffrey L. Sheean,101 a neurologist at Scripps
Clinic Medical Group in La Jolla, California, complaining of myasthenia gravis (to which Dr.
Sheean added a question mark) and dysautonomia. Med. recs. Ex. 116, at 1. Petitioner told Dr.
Sheean she had flu vaccine two weeks before her rhabdomyolysis and, one week later, leg
weakness neck extensor weakness, dysarthria, and dysphagia. Id. He notes petitioner did not
have exertional dyspnea, ptosis,102 diplopia, blurred vision, or dry mouth. Id. He also notes that
CT and MRI chest scans did not show thymic103 abnormality. Petitioner told Dr. Sheean that her
reflexes disappeared and reappeared with prescriptions. Id. at 2. Dr. Sheean attributed
petitioner’s vertigo episodes to likely benign positional vertigo (“BPV”). A SPECT scan of
petitioner’s brain suggested vasculitis, but she did not have central nervous system symptoms.
Id. An angiogram, which Dr. Sheean wondered was really an MRA, did not show vasculitis. Id.
        On physical examination, petitioner had moderate symmetrical weakness in her face,
tongue, jaw, neck extensors, proximal upper and lower limbs, girdle muscles, and distal upper
limb muscles (intrinsic hand), with no post-activation improvement in strength. Id. Petitioner
did not have atrophy or fasciculations. Her motor effort was very shaky, but she did not have
any proprioceptive deficit. Her Romberg was negative. Her reflexes tested at zero or 1+, with
no obvious post-activation facilitation, but petitioner would have a coughing spell after effort,

100
    Northera contains droxidopa, which is a synthetic amino acid precursor of norepinephrine, used for the treatment
of orthostatic dizziness, lightheadedness, and other illnesses. Northera, RXLIST, https://www.rxlist.com/northera-
drug.htm#description (last visited Feb. 4, 2019).
101
    Dr. Sheean is from Australia. He is not board-certified in neurology in the US. The undersigned could not find
him board-certified in other areas. Is My Doctor Board Certified?, AMERICAN BOARD OF MEDICAL SPECIALTIES,
https://www.certificationmatters.org/find-my-doctor/?search=Geoffrey&lname=Sheean&state=CA&specialty=1012
(last visited Mar. 19, 2019). He graduated from the University of Queensland Faculty of Health Sciences in 1984
and is a research physician, specializing in electrophysiology. About Dr. Geoffrey Sheean, MD, U.S. NEWS
HEALTH, https://health.usnews.com/doctors/geoffrey-sheean-984802 (last visited Mar. 19, 2019); Dr. Geoffrey
Sheean, MD, HEALTHGRADES, https://www.healthgrades/com/physician/dr-geoffrey-sheean-2ktfw (last visited Mar.
19, 2019). Dr. Sheean was licensed to practice medicine in California on June 28, 2002. He did not identify having
any board certifications to the Medical Board of California. The website information is self-reported. Medical
Board of California, DCA SEARCH,
https://search.dca.ca.gov/details/8002/A/79636/4aa0336fbf751a885ccecba6541c977c (last visited Mar. 19, 2019).
102
    Ptosis is “drooping of the upper eyelid.” Dorland’s at 1551.
103
    The thymus “is the site of production of T lymphocytes.” Dorland’s at 1925.

                                                        54
making testing difficult. Id. Petitioner’s pupils were 5-6mm and poorly reactive. Id. at 3. She
had mild ptosis bilaterally, left > right, which was non-fatiguable. A Cogan’s lid sign104 was
absent. Extraocular movement (“EOM”) showed normal pursuits with bilateral hypometric105
horizontal saccades.106 Her eyes were white. Her mouth was not dry. Id.
        Dr. Sheean diagnosed petitioner with acute, progressive, severe dysautonomia involving
the gastrointestinal, genitourinary, and cardiovascular systems, noting POTS and questioning
Raynaud’s, with possibly pupillary dysautonomia. Id. He also diagnosed petitioner with
myasthenia, but he was unsure if it were myasthenia gravis (“MG”) or Lambert-Eaton
myasthenic syndrome (LEMS).107 He entertained the possibility that petitioner could have mild
residual myositis (CKs).
       Dr. Sheean then considered four possible triggers: (1) flu vaccine leading to autoimmune
myositis with rhabdomyolysis, triggering myasthenia gravis, and vaccine-triggered
dysautonomia; (2) flu vaccine leading to autoimmune myositis with rhabdomyolysis, triggering
LEMS; (3) acute viral myositis causing rhabdomyolysis, triggering MG+dysautonomia, or
LEMS; or (4) acute autoimmune attack causing myositis (largely self-limiting) plus
MG+dysautonomia or LEMS. Id.
         Dr. Sheean stated:
                  The severity of the dysautonomia argues against Lambert-Eaton
                  myasthenic syndrome and that is supported by the very good
                  response of the weakness to pyridostigmine. However, Lambert-
                  Eaton myasthenic syndrome is still a plausible diagnosis and [since
                  petitioner is] a young woman, would almost certainly be
                  nonmalignant, not to mention that it has been more than 5 years
                  since the onset. It is also important to distinguish myasthenia
                  gravis from Lambert-Eaton myasthenic syndrome because of the
                  option of thymectomy for myasthenia gravis, despite the absence
                  of thymic enlargement.
Id.

104
    Eric L. Singman et al., Use of the Cogan Lid Twitch to Identify Myasthenia Gravis, 31 J NEUROOPHTHALMOL
239 (2011). Of 117 patients evaluated, 24 had myasthenia gravis, of whom 18 had a positive lid twitch. Patients
were instructed to look straight, up, down, and straight again. If the upper eyelids had a brief upward twitch, this
indicated a positive Cogan Lid Twitch test.
105
    Hypometria is “dysmetria in which voluntary muscular movement falls short of reaching the intended goal.”
Dorland’s at 903.
106
    Saccadic movement is “the quick movement of the eye in going from one fixation point to another.” Dorland’s at
1184.
107
    Lambert-Eaton myasthenia syndrome is “an autoimmune, myasthenialike syndrome caused by autoantibodies to
the voltage-gated calcium channel (anna 1 antibodies) that interfere with the release of acetylcholine at the motor
nerve terminal. Weakness usually affects the limbs, but ocular and bulbar muscles are spared; there is reduced
muscle action potential on stimulation of its nerve but with repetitive stimulation it becomes augmented. It is often
associated with oat-cell carcinoma of the lung.” Dorland’s at 1836.

                                                         55
        Dr. Sheean further stated petitioner clearly needed to start immunosuppressants and
recommended CellCept (mycophenolate mofetil)108 for six months, with monthly monitoring of
her complete blood cells and comprehensive metabolic panel. If CellCept failed, he would
switch petitioner to tacrolimus.109 After that, he would put her on rituximab.110 He suggested
she receive zoster vaccine. He suggested petitioner increase her IVIG because her myasthenia
was still very symptomatic. He recommended repetitive nerve stimulation and short exercise
testing for post-activation facilitation, which should distinguish between MG and LEMS. If not,
petitioner would need stimulated single-fiber EMG. Id. He noted that voltage-gated calcium
channel antibodies would indicate LEMS. Id. at 4. He ordered repeat testing of AChR
antibodies and LRP4 antibodies.111 If they were negative, he would repeat testing for MuSK.
He would test for SSA/SSB antibodies for primary Sjögren’s syndrome. In addition, he would
check voltage-gated potassium channel antibodies for dysautonomia. Id.
       On January 29, 2015, petitioner was tested for numerous antibodies, all of which were
negative: SSA antibody and SSB antibody to test for Sjögren’s; acetylcholine receptor
modulating antibody; acetylcholine receptor blocking antibody; voltage-gated calcium channel
antibody; voltage-gated potassium channel antibodies. Id. at 6-11.
        On February 10, 2015, petitioner had repetitive nerve testing, which was normal. Id. at
12. Dr. Sheean reviewed her other tests results, all of which were negative: voltage-gated
potassium channel antibodies, voltage-gated calcium channel antibodies, acetylcholine receptor
antibodies, and Sjögren’s antibodies. However, the laboratory had difficulty obtaining LRP4
antibodies. Dr. Sheean believed that the most likely form of myasthenia that petitioner had was
myasthenia gravis Robinson Lambert-Eaton myasthenic syndrome. Id. Dr. Sheean thought it
might be prudent to check to see if petitioner had MuSK antibodies, but there might be an option
for thymectomy. A thymectomy would not help if she did have MuSK antibodies or Lambert-
Eaton myasthenic syndrome. It also would not affect her autonomic neuropathy. Dr. Sheean
thought petitioner’s autonomic neuropathy could be a ganglionopathy perhaps due to antibodies
to ganglionic acetylcholine receptors. Petitioner decided not to have a thymectomy and opted to
proceed with immunosuppression and continue IVIG. Because petitioner had problems with
aseptic meningitis, Dr. Sheean recommended premedication with Solu-Medrol to prevent
infusion-related headaches. Id. Dr. Sheean recommended increasing IVIG dosage and starting
CellCept. Id.

108
    Mycophenolate mofetil is “an immunosuppressive agent used in conjunction with cyclosporine and
corticosteroids to prevent rejection of allogeneic renal, hepatic, and cardiac transplants.” Dorland’s at 1216.
109
    Tacrolimus is “a macrolide suppressant of the calcineurin inhibitor group, derived from Streptomyces
tsukubaensis and having actions similar to those of cyclosporine. Administered orally or intravenously to prevent
rejection of organ transplants, especially liver.” Dorland’s at 1868.
110
    Rituximab is “a chimeric murine/human monoclonal antibody that binds the CD 20 antigen; used as an
antineoplastic in the treatment of CD20-positive, B-cell non-Hodgkin lymphoma.” Dorland’s at 1650.
111
    LRP4 antibodies are lipoprotein receptor-related protein 4 antibodies. “Recently, the novel antigen, the low-
density lipoprotein receptor-related protein 4 (LRP4), has been identified as a target for the autoantibodies in MG.”
Goichi Beck et al., Double Seronegative Myasthenia Gravis with Anti-LRP4 Antibodies Presenting with Dropped
Head and Acute Respiratory Insufficiency, 55 INTERN MED 3361, 3361 (2016).

                                                          56
        Also, on February 10, 2015, petitioner underwent another EMG/NCS. Id. at 13.
Repetitive nerve stimulation was done on petitioner’s right ulnar, accessory (trapezius) radial,
and median nerves at rest and after exercise, in the absence of pyridostigmine. Petitioner did not
have any abnormal decrement. A short exercise test was performed on the right radial and
median nerves with no significant post-activation facilitation. Dr. Sheean’s interpretation was,
“At present, there is no indication of a neuromuscular junction disorder.” He notes, however,
that petitioner was receiving IVIG. Id.
        On March 5, 2015, petitioner saw Dr. Gee. Med. recs. Ex. 140, at 2. Petitioner reported
that she was doing better with the higher IVIG dose. Id. On physical examination, petitioner’s
motor skills, balance, and gait were intact. She did not have language deficits. Her deep tendon
reflexes were preserved. Id. at 3. Dr. Gee recommended petitioner return every three to four
months. Id. at 2.
       On March 25, 2015, April 9, 2015, and August 3, 2015, petitioner saw Dr. Craig A.
Salcido, an obstetrician-gynecologist, to seek consultation and treatment including a
hysterectomy. Med. recs. Ex 173, at 1-5.
       On July 17, 2015, petitioner saw Dr. Gee and discussed her intent to have a
hysterectomy. Med. recs. Ex. 140, at 7. Petitioner appeared to be stable. Id. On physical
examination, Dr. Gee noted petitioner did not have language deficits and her motor skills,
balance, and gait were intact. Id. at 9.
        On August 7, 2015, Dr. Salcido performed a power morcellation laparoscopic
supracervical hysterectomy. Med. recs. Ex. 173, at 12; see also Ex. 140, at 11-16. Petitioner
also received a pulmonary consultation from Dr. Robert Y. Goldberg on the day of her
hysterectomy. Med. recs. Ex. 140, at 17. Dr. Goldberg assessed that petitioner “has a history of
laryngeal spasm and myasthenia gravis.” Id. His plan was to monitor petitioner postoperatively,
monitor her respiratory status with vital capacities only, and “should respiratory status become
compromised,” he would have a low threshold to intubate. Id. Petitioner’s EKG report, dated on
the day of her procedure, showed that petitioner had normal sinus rhythm and a normal EKG.
Med. recs. Ex 173, at 10. On August 10, 2015, Dr. Oscar H. Otanez’s pathology report
diagnosed “uterine tissue with benign glands and stroma; bilateral fallopian tubes with no
significant histopathologic changes; negative for malignancy.” Id. at 11.
        On August 21, 2015, petitioner had a post-operation visit with Dr. Salcido, who noted
that petitioner was “doing great,” “very happy,” and healing well. Id. at 12.
        On June 15, 2016, during the second day of the hearing in this case, petitioner collapsed
on the floor of the hearing room and was transported via EMS to the ED at MedStar Georgetown
University Hospital. Med. recs. Ex. 179, at 1. Petitioner was “having difficulty breathing” and
was nonverbal; she wrote for the EMTs that she could be treated only with Mestinon. Id. at 2.
Petitioner reported that she “has a genetic disorder call[ed] (myasthenia gravis).” Id. Petitioner
had “no swelling to tongue, mouth or face,” and “she doesn’t feel as though her throat is
closing.” Id.

                                                57
        At MedStar ED, Dr. Eric A. Glasser noted that petitioner was calm considering the
amount of stridor she was having. Med. recs. Ex. 180, at 1. He requested a neurologic
consultation. Id. at 2. Nurse Conway Luu noted petitioner’s respiration at 1:20 p.m. to be
diaphragmatic, gasping, grunting, labored, and shallow, with tachypnea112 and use of accessory
muscles. Id. at 25. Her respiratory pattern was described as regular. Id. Petitioner used
furniture to assist herself in walking. Id. at 26. At 1:52 p.m., Nurse Luu noted petitioner was
able to speak in full sentences, with slurred speech and wheezing to auscultation. Id. at 27. She
had significant improvement in respirations, which were more relaxed. At 4:56 p.m., Nurse Luu
noted petitioner had audible stridor bilaterally with shortness of breath. Id.
        Dr. Brian Barry, a neurologist, spoke with petitioner who reported that she had an acute
onset of shortness of breath associated with difficulty talking. Id. at 3. Petitioner said she had
been recently sick with a sore throat, nasal congestion, mild weakness, and shortness of breath
the prior night. However, she walked normally that morning. Around noon, she became acutely
worse, and came to the ED. Petitioner denied problems with swallowing or diplopia but reported
her lower extremities were weak. She said she had been unable to walk for the prior half-hour
before arrival. Petitioner told Dr. Barry that she had never been intubated for myasthenia, and
that she had been managed on BiPAP previously after she had similar symptoms in 2013. She
said she took Mestinon at home as needed which greatly helped her symptoms, but she had not
taken Mestinon that day. She said she was overdue for maintenance IVIG. Petitioner
communicated with Dr. Barry through writing because she was not talking. She complained of
fatigue. Id.
        Dr. Barry did a physical examination of petitioner. Id. at 4. She was in mild distress and
anxious. She did not have any wheezing. She had mild to moderate ptosis bilaterally which she
could overcome spontaneously with upgaze and which did not worsen with fatigue. She had
mild weakness in eyelid closure. She did not have nystagmus. Id. On motor examination,
petitioner had normal bulk and tone. Id. at 5. She had bilateral drift and could sustain
antigravity proximally for 1-2 seconds before the limb dropped. At maximum effort, her
strength was 4/5 and symmetric. Her neck flexion and extension were 4/5. Her sensation was
intact symmetrically to fine touch. She could do finger to nose bilaterally without dysmetria or
tremor. Her reflexes were 2 everywhere except in the Achilles tendons where they were 1. Her
big toes were downgoing. Dr. Barry’s diagnosis was acute dyspnea. Her neurologic
examination was significant for ptosis, weakness in eyelid closure, and diffuse weakness.
However, she possibly had an element of effort dependence. Her negative inspiratory force
(“NIF”) was within normal and her arterial blood gases (“ABG”) were reassuring. Id. Dr. Barry
noted that petitioner’s history was concerning for myasthenic exacerbation vs. crisis; however,
her vital signs, NIF, and ABG were stable on admission. Id. at 5-6. Petitioner initially made
“lots of upper airway noises with excellent respiratory effort,” which are “inconsistent with MG
weakness” and “more consistent with vocal cord dysfunction.” Id. at 6. This resolved after a
single dose of Mestinon.

112
      Tachypnea is “excessive rapidity of breathing.” Dorland’s at 1868.

                                                          58
       Dr. Barry discussed petitioner’s case at length with petitioner’s physician Dr. Gee in
California, who said a specialist at Scripps (which would be Dr. Sheean) diagnosed petitioner
with seronegative MG with autonomic features. However, on multiple occasions, petitioner
came to Dr. Gee with upper airway noises and shortness of breath. She was admitted to the
hospital multiple times with this complaint. She was on monthly IVIG and was frequently
admitted to the hospital with “low NIFs”, but “no neuromuscular cause was believed to be
associated with these spells.” Id. Her myasthenia has been stable. Also, petitioner had
“previously been assessed for non-organic dystonia attributed to a flu shot.” Id.
        On June 16, 2016, at 11:45 a.m., registered and licensed dietician Kelsie N. Hitesman
noted that petitioner had “psychogenic stridor” and said she was currently unable to tolerate
anything orally due to stridor and hesitance to swallow food, liquids, or medicine. Med. recs. Ex
183, at 90. Petitioner said she had been unable to take anything orally for two to three weeks and
would take only oat milk via a feeding tube. Id. at 91. However, petitioner denied any weight
changes in the last six months. Id.
        On June 17, 2016, petitioner was discharged with a diagnosis of myasthenia gravis. Med.
recs. Ex. 180, at 8. Petitioner was instructed to continue taking her medications as prescribed
and to follow up with her outpatient neurologist within two weeks. Id. at 13.
        On August 4, 2016, petitioner saw Dr. Sheean at Scripps to review her neurological
condition and “provisional” diagnosis of myasthenia gravis. Med. recs. Ex 185, at 1. Dr. Sheean
noted petitioner felt much better now that she was off oral contraceptives following her
hysterectomy. She was now back working and did not have any more nocturnal shortness of
breath. She was more active, which caused some muscle aching. She did not have evidence of
joint hypermobility. Id. She had a continuing benefit from monthly IVIG, 2G per kg over three
days, but it initially worsened her vertigo and autonomic symptoms (necessitating her using a
feeding tube afterwards for two weeks). Id.
        Petitioner reported right eyelid ptosis “now.” Id. Dr. Sheean’s physical examination of
petitioner showed mild left ptosis. She also complained of poor visual tracking and diplopia,
which was worse at the end of the day. Both symptoms responded to Mestinon. Petitioner said
she was always dehydrated and had episodes of stridor that forceful inspiration, which occurred
during pulmonary function tests, triggered. This resolved with IVIG. Her POTS was
manageable. Petitioner was more troubled by weakness and fatigue, as well as her
gastrointestinal autonomic symptoms. Dr. Sheean concluded petitioner likely had generalized,
seronegative myasthenia gravis, especially with the addition of ptosis and diplopia. He discussed
with petitioner her having a thymectomy, and testing for MuSK antibodies and LRP4 antibodies.
He diagnosed petitioner with dysautonomia (gastroparesis and POTS), and episodic stridor
which was likely laryngospasms that her forceful inspiration triggered. Id.
        Dr. Sheean planned to retest petitioner for MG antibodies, including MuSK with an
option for LRP4 antibodies if MuSK antibodies were negative. Id. at 2. If petitioner’s MuSK
antibodies were negative, he would repeat the single-fiber EMG with petitioner off IVIG, trying
“to obtain better evidence of myasthenia gravis before considering thymectomy.” Id. He would

                                               59
consider a low dose of IVIG which might help both petitioner’s dysautonomia and myasthenia.
Id.
        Dr. Sheean had petitioner undergo various tests. She had a high result for glutamic acid
decarboxylase antibody (“GAD ab”), which was 22.2 when the normal range is 0.0-5.0U/ml. Id.
at 3. Petitioner’s creatine kinase (“CK”) level was normal at 109 (reference range 26-192
units/L). Id. at 4. She was negative for Sjögren’s antibodies (SSA and SSB antibodies). Id. at 8.
She was normal for ceruloplasmin. Id. at 9. She was negative for MuSK antibody. Id. at 10.
        On August 11, 2016, petitioner saw Dr. Gee. Med. recs. Ex 186, at 1. Dr. Gee noted
petitioner had a positive GAD antibody, myasthenic syndrome, and muscle spasm. He counseled
petitioner on the importance of the GAD antibody and the potential diagnosis of stiff person
syndrome113 and variant cerebellar ataxia. Id. He wrote orders for petitioner to test for GAD65,
IA-2, and insulin autoantibody. Id. For review of systems, Dr. Gee wrote petitioner was
negative for fatigue, dyspnea, wheezing gait disturbance, and psychiatric symptoms. Id. at 2.
Upon physical examination, petitioner appeared well-nourished, alert, and oriented, with intact
range of motion, no spasms, intact knowledge, no language deficits, normal attention span and
concentration, fluent speech, no motor or sensory deficits, normal fine motor skills, and intact
coordination, balance, and gait. She had preserved reflexes. Id.
         On August 19, 2016, petitioner saw Dr. Sheean at Scripps to review her test results.
Med. recs. Ex 188, at 1. The test results were as follows: (1) negative acetylcholine receptor
antibodies and MuSK antibodies; (2) negative Mayo Clinic autonomic antibody panel--SSA,
SSB, and Fodrin antibodies; (3) celiac haplotype risk <0.1x; and (4) positive GAD antibodies
22.2 (<5). Id. Petitioner reported that she experienced episodes of stridor and neck spasms in
response to IVIG and questioned if she had stiff person syndrome. Id. Petitioner reported that
she was clumsy and fell especially in the dark. Dr. Sheean thought her ataxia was sensory rather
than cerebellar. She had a positive Romberg’s sign and deafferentation114 pseudoweakness with
irregular motor effort on examination that she stabilized with visual fixation. The morning of her
visit, all of petitioner’s involuntary movements were slow, almost apraxic.115 Her extraocular
movements did not show nystagmus but seemed difficult for her to perform. Id.
         Dr. Sheean assessed that petitioner has:
                  (1) Likely seronegative myasthenia gravis;
                  (2) Dysautonomia: cardiovascular (orthostatic) and gastrointestinal
                      predominantly;
                  (3) Sensory ataxia, which did not appear to be cerebellar;

113
    Stiff person syndrome is “a condition of unknown etiology characterized by progressive fluctuating rigidity of
axial and limb muscles in the absence of signs of cerebral and spinal cord disease but with continuous
electromyographic activity; some cases have been linked to autoimmune conditions.” Dorland’s at 1849.
114
    Deafferentation is “the elimination or interruption of afferent nerve impulses, as by destruction of the afferent
pathway.” Dorland’s at 473. The afferent pathway is “the nerve structures through which an impulse, especially a
sensory impression, is conducted to the cerebral cortex.” Id. at 1397.
115
    Apraxia is “loss of ability to carry out familiar, purposeful movements in the absence of paralysis or other motor
or sensory impairment.” Dorland’s at 121.

                                                          60
                  (4) Cognitive impairment, likely autoimmune encephalopathy;
                  (5) Episodic muscle spasms, including laryngeal and cervical,
                      possibly manifestations of stiff person syndrome, with
                      accompanying anti-GAD antibodies; and
                  (6) Appears to have an incomplete DAME Syndrome
                      (Dysautonomia, Autoimmune disease, Mast cell116 activation
                      disorder, Ehlers-Danlos syndrome117); absence of mast cell
                      activation disorder.
Id. at 1-2. Dr. Sheean’s plan was to “continue current IVIG regimen, recommend adding
CellCept, 1G twice a day, advise against thymectomy for now.” Id. at 2.
        On August 14, 2016, petitioner had insulin autoantibody, GAD65 antibody, and IA-2
antibody tested. Med. recs. Ex. 189, at 1. Her insulin autoantibody result was normal. Her
GAD65 antibody was high at 11 when the reference range was <5 IU/ml. Her IA-2 antibody
result was normal. Id.
        On January 16, 2017, petitioner saw Dr. Gee, complaining of weakness. Med. recs. Ex.
207, at 1. Dr. Gee stated petitioner was doing well and was stable. Id. He notes that her
myasthenic syndrome resolved August 11, 2016. Id. He also notes that her POTS resolved on
September 23, 2013. Id. He notes she had a prolonged QT interval.118 Id. On physical
examination, petitioner had intact range of motion and no spasms. Id. at 3. She was alert and
oriented, with intact knowledge, normal attention span and concentration, fluent speech, and no
language deficits. Id. She did not have any motor or sensory deficits, her fine motor skills were
normal, her coordination, balance, and gait were intact, and she had preserved reflexes. Id.
        On January 13, 2017, petitioner’s GAD65 antibody was tested. Id. at 4. The result was
high at 6 when the reference range was >5IU/ml. Id.
       On May 2, 2017, petitioner had her GAD65 antibody tested. Med. recs. Ex 204, at 1.
The result was high at 37 when the reference range was <5IU/ml. Id.
        On July 17, 2017, petitioner saw Dr. Gee, stating she had been under stress, and had
spasms and a bad rash along her trunk after taking Octagam.119 Med. recs. Ex. 207, at 6. The
review of systems and physical examination were normal. Id. at 7-8. Dr. Gee diagnosed
petitioner with myasthenic syndrome, stiff person syndrome, POTS, positive GAD antibody, and

116
    Mast cell is “a type of connective tissue cell whose specific physiologic function remains unknown; it can
elaborate basophilic, metachromatic, cytoplasmic granules that contain histamine and heparin in humans.”
Dorland’s at 320.
117
    Ehlers-Danlos syndrome is “a group of inherited disorders of the connective tissue. The major manifestations
include hyperextensible skin and joints, easy bruisability, friability of tissues with bleeding and poor wound healing,
calcified subcutaneous spheroids, and pseudotumors.” Dorland’s at 1828.
118
    The QT interval is “in electrocardiography, the time from the beginning of the Q wave to the termination of the S
wave, representing the time for ventricular depolarization.” Dorland’s at 951.
119
    Octagam is immune globulin intravenous preparation for treatment of primary humoral immunodeficiency.
Common side effects include headache and nausea. Octagam, RXLIST, https://www.rxlist.com/octagam-side-
effects-drug-center.htm (last visited Feb. 5, 2019).

                                                          61
pruritic rash. Id. at 8. Dr. Gee suggested petitioner try immunoglobulin, but not Octagam. Id.
Dr. Gee’s plan was to refer petitioner to dermatology for evaluation and treatment, request
testing for immunoglobins, and renew carimune120 and diazepam. Id.
       On July 25, 2017, petitioner was tested for Immunoglobulin A, G, M, and E. Id. at 9.
The results were normal. Id.
                                          Medical Expert Reports
        On October 22, 2013, petitioner filed the expert report of Dr. Lawrence Steinman. Ex.
65. Petitioner also filed on that date Dr. Steinman’s CV. Ex. 66. On June 1, 2015, petitioner
filed an updated CV, which Dr. Steinman dated May 23, 2015. Ex. 119. On January 13, 2016,
petitioner filed another updated CV, which Dr. Steinman dated December 14, 2015. Ex. 143.121
Dr. Steinman is board certified in neurology. Id. at 2. He is Professor of the Departments of
Neurology and Neurological Sciences, Pediatrics and Genetics at Stanford University. Id. at 1.
He is also incumbent of the G.A. Zimmermann Chair as Professor of Neurological Sciences,
Neurology, and Pediatrics. Id. In 2004, he won the John M. Dystel Prize for Outstanding
Contributions in Multiple Sclerosis Research, National MS Society and the American Academy
of Neurology. Id. In 2009, he was elected to the Institute of Medicine, renamed in 2015 as the
National Academy of Medicine. Id. In 2011, he won the Charcot Prize for Lifetime
Achievement in MS Research—International Federation of MS Societies. Id. In 2015, he was
elected to the National Academy of Sciences.122 Id. Dr. Steinman has 38 patents. Id. at 2-3.
He is associate editor of the journal Neurobiology of Disease. Id. at 4.
        Dr. Steinman had been on the board of directors of Centocor from 1991-99 when it was
sold to Johnson and Johnson.123 Id. He was the founder advisor of Neurocrine Biosciences
from 1992-2005, and on the board of directors from 2001-2005. He was on the scientific
advisory board (“SAB”) of Roche Biosciences from 1998-2002. He was the founder of Bayhill
Therapeutics, head of its SAB from 2011, and a member of the board of directors. He was the
founder and a board member of Atreca, Cardinal Therapeutics, and Tolerion. He was the

120
    CSL Behring, the manufacturer of Carimune, an immune globulin intravenous product, discontinued its
production in the third quarter of 2018. CSL Behring to Discontinue Production of Carimune NF, IMMUNE
DEFICIENCY FOUNDATION, https://primaryimmune.org/news/csl-behring-discontinue-production-carimune-nf (last
visited Feb. 5, 2019).
121
    Posted on the internet in PDF format is the latest version of his CV, dated July 14, 2018. Rather than the 514
articles Dr. Steinman authored or co-authored listed on his December 14, 2015 CV, his 2018 CV lists 566 articles.
Curriculum Vitae Lawrence Steinman, MD, STANFORD PROFILES,
https://cap.stanford.edu/profiles/viewCV?facultyId=3784.Lawrence_Steinman (last visited Mar. 8, 2019).
122
    The National Academy of Sciences lists Dr. Steinman’s research interests as the pathogenesis of multiple
sclerosis and related neuroinflammatory diseases; development of antigen-specific tolerance therapy for
autoimmune diseases where the autoantigen is clearly defined, particularly type 1 diabetes and neuromyelitis optica;
and the pathogenesis and therapy of diseases in which amyloid structures are central in pathogenesis, including
Huntington’s disease and Alzheimer’s. Member Directory. Lawrence Steinman, NATIONAL ACADEMY OF SCIENCES,
www.nasonline.org/member-directory/members/14142.html (last visited Mar. 8, 2019).
123
    Johnson & Johnson announced its purchase of Centocor for $4.9 billion in stock on July 21, 1999. Johnson &
Johnson to Acquire Centocor, THE NEW YORK TIMES (July 22, 1999),
https://www.nytimes.com/1999/07/22/business/johnson-johnson-to-acquire-centocor.html.

                                                        62
founder and head of the SAB of Transparency Life Sciences. He was on the SAB of Receptos124
starting in 2012 until the date of this CV, May 23, 2015. Dr. Steinman has also been affiliated
with Janssen Biotech, Inc., Peptimmune, Inc., Garnet Biotherapeutics, Inc., Neurion
Pharmaceuticals, Inc., Provid Pharmaceuticals, Inc., Biocon Limited, Vaccinex, Inc., Horizon
Pharmaceutical LLC, KAHR Medical Ltd., BioAtla, LLC, Sequenta, Inc., Syapse, Bionure, Inc.,
and Applied Therapeutics, Inc.125
       Dr. Steinman’s opinion is that petitioner developed profound neurologic and muscle
disturbances with rhabdomyolysis followed by serious autoimmune dysautonomia, a type of
inflammatory autoimmune neuropathy, whose onset was approximately September 3, 2009,
about 10 days after she received flu vaccine. Ex. 65, at 1. He states flu vaccine caused her
rhabdomyolysis and autoimmune dysautonomia due to molecular mimicry between flu vaccine
and myelin proteins (“MBP”) leading to nervous system inflammation. Id. He says there are
MBP sequences with which various viruses, including influenza virus A, can cross-react. Id. at
11.
        Dr. Steinman states that portions of the autonomic nervous system are myelinated. Id. at
14. Thus, inflammation directed to myelin can affect autonomic function. Id. at 15. He writes
activation of petitioner’s innate immune system exacerbated a chain reaction of autoimmune
reactions, including many serologic indications that she has lupus in addition to dysautonomia.
Id. at 17. Dr. Steinman does not mention the fact that all the serologic testing of petitioner
resulted in the conclusion that she does not and never did have lupus. He also focuses intently
on how flu vaccine causes Guillain-Barré syndrome (“GBS”), but he does not mention the fact
that doctors tested petitioner for GBS and concluded she did not have it. Dr. Steinman states:
                Activation of innate immunity and adaptive immunity to influenza
                vaccine components is the more likely reason that immunity to
                myelin occurred in [petitioner’s] case. The autonomic nervous
                system is myelinated in many of its anatomic locations, and
                autonomic dysautonomia is at times a major feature of
                inflammatory demyelinating neuropathy and at times GBS.
                Autoimmune neuropathies with dysautonomia are often the result
                of immunity directed to the ganglionic AChR. Once inflammation
                is induced to myelin proteins via molecular mimicry to the
                influenza vaccine, various pathogenic reactions occur including
                autoimmune ganglionopathy.
Id. at 19.

124
    Celgene bought Receptos for $7.2 billion in cash, announced July 14, 2015. Celgene to Acquire Receptos,
Advancing Leadership in Immune-Inflammatory Diseases, CELGENE (July 14, 2015), https://ir.celgene.com/press-
releases/press-release-details/2015/Celgene-to-Acquire-Receptos-Advancing-Leadership-in-Immune-Inflammatory-
Diseases/default.aspx.
125
    Executive Profile. Lawrence Steinman, Co-Founder and Member of Scientific Advisory Board, Nuon
Therapeutics, Inc., BLOOMBERG, (March 8, 2019),
https://www.bloomberg.com/research/stocks/private/person.asp?personId=1153833&privcapId=35786930.

                                                     63
        Dr. Steinman states petitioner had autoimmune autonomic ganglionopathy (“AAG”). Id.
at 20. He reflects that no one tested petitioner for antibody to ganglionic acetylcholine receptor,
which would appear in 50% of patients with autoimmune ganglionopathy. Id. at 21. However,
he states whether petitioner tested positive or negative for antibody to ganglionic acetylcholine
receptor would not “undermine” his conclusion. But if petitioner did have a positive result on
testing for antibody to ganglionic AChR, that would be an important finding. Id. Dr. Steinman
notes this is a “complex case,” but he has a “high degree of medical certainty” that flu vaccine
caused petitioner’s rhabdomyolysis and subsequent autoimmune dysautonomia due to an
autoimmune inflammatory neuropathy. Id.
        On April 25, 2014, respondent filed the expert report of Dr. Peter D. Donofrio. Ex. B.126
Respondent also filed on that date Dr. Donofrio’s CV. Ex. C. Dr. Donofrio is board certified in
neurology, electrodiagnostic medicine, and internal medicine. Id. at 2. At the time of the filing
of his expert report, he was Director and Professor of Neurology at the Vanderbilt University
School of Medicine, Neuromuscular Division. Id. He was a fellow with the American Academy
of Neurology, and a member of the following associations: American Association of
Electromyography and Electrodiagnosis, the American Neurological Association, the American
Medical Association, and the Tennessee Neurological Association. Id. at 3. He authored or co-
authored 86 articles (id., at 12-20), 12 book chapters (id., at 20-21), 83 abstracts (id., at 21-28),
and 13 monographs (id., at 28-29).
        Dr. Donofrio notes that petitioner’s medical records show that her jerking and dystonic
posturing improved when a doctor distracted her and her movements tended to fluctuate during
the day. Id. at 7. She also had a speech aberration. Both the senior neurology resident and the
neurology attending physician at Johns Hopkins University in early October 2009 had a strong
suspicion that petitioner had a non-physiologic disorder. She was able to run, but not to walk
forward unless she put her hand on her thigh. Her speech worsened when she rose from a chair,
but her blood pressure did not change. Id. Dr. Donofrio notes that petitioner’s expert Dr.
Steinman ignored all these anomalies in petitioner’s presentation and failed to explain how they
are consistent with his diagnosis in his expert report. Dr. Donofrio states he is unaware of any
neurologic condition that would manifest the way petitioner’s condition manifested. Id.
Petitioner’s head CT scans, brain MRIs with and without contrast, and PET CT scan were
normal and did not show brain pathology that would cause a movement disorder or autonomic
dysfunction. Dr. Donofrio states petitioner’s movement disorder cannot be related to any form
of dysautonomia. Id.
         As for petitioner having POTS, testing did not show petitioner had a significant change in
pulse or blood pressure during up-tilt testing to substantiate the diagnosis of either POTS or
orthostatic hypotension. Id. at 7-8. To diagnose POTS, petitioner should have had a 30-point
rise in her pulse within the first 10 minutes of tilting or a pulse greater than 120 within the first
10 minutes in the setting of little change in blood pressure. Id. at 8. In addition, petitioner did
not have blood pressure features of an autonomic neuropathy because she should have had a

126
   On August 15, 2013, respondent filed Exhibit A (A1 to A5). It is a CD of video files originally in Final Cut Pro
format (petitioner’s Exhibit 58), which respondent converted to a format viewable in Windows Media Player.

                                                         64
profound drop in blood pressure when she stood or was tilted up associated with little change in
her pulse. Id.
        Dr. Donofrio stated if petitioner had dysautonomia from autoimmune ganglionopathy,
she should have had clinical symptoms and signs of a global autonomic disorder, i.e., sluggish
pupillary responses, dry eyes and mouth, slow pulse, documented orthostatic hypotension,
gastric bloating, constipation, urinary retention, sexual dysfunction, and dry skin. Id. These
findings are not in her medical records. Dr. Donofrio notes that in November 2013, petitioner
denied any autonomic features, including nausea, vomiting, abdominal pain, and dizziness. Dr.
Donofrio stated petitioner did not have pulse or blood pressure features of either POTS or
orthostatic hypotension. Id.
         Dr. Donofrio observes that petitioner had a pre-existing history of recurrent bronchitis
since February 2009 and a probable viral illness in early September 2009 because she had sore
throat, fever, chills, muscle aches, and fatigue. Id. She was thought to have viral myositis, but
continued training for a 5K race. In her September 12-14, 2009 hospitalization, the diagnosis
was viral myositis because her creatine kinase values were very high at 12,000, although her
neurologic examination was normal including normal deep tendon reflexes. Because petitioner
had normal deep tendon reflexes and normal strength, she was not diagnosed with GBS.
Moreover, GBS rarely causes elevated creatine kinase levels and, when it does, the elevation is
mild and not 12,000. Petitioner also had normal reflexes when she went to Johns Hopkins
University on October 3, 2009. Because of her neurological evaluations at Inova Loudon and
Johns Hopkins, Dr. Donofrio does not believe petitioner had GBS. Id.
        Dr. Donofrio thinks petitioner’s viral illness rather than her flu vaccination caused her
rhabdomyolysis since the vaccination occurred on August 23, 2009, but her symptoms did not
develop until early September 2009, about 10 days later. Id. He notes that rhabdomyolysis is
common in athletes and people who participate in regular, strenuous physical activity. Petitioner
ran daily to prepare for a race. Id. Dr. Donofrio says that even if the vaccination caused
rhabdomyolysis, it would not predispose petitioner to an autoimmune dysautonomia. Id. at 8-9.
The muscle breakdown causing elevated CK levels after a viral illness is due to the virus’s effect
on muscle rather than to autoimmune disease. Id. at 9.
         On August 14, 2014, petitioner filed Dr. Steinman’s first supplemental expert report. Ex.
92. He states dysautonomia or autonomic dysfunction is a broad term describing any disease or
malfunction of the autonomic nervous system (“ANS”). Id. at 1. The ANS controls numerous
bodily functions, e.g., heart rate, blood pressure, digestive tract peristalsis, and sweating.
Because dysregulation of the ANS can produce apparent malfunction of the organs it regulates,
patients with dysautonomia often present with numerous, seemingly-unrelated maladies. Id. He
lists the types of dysautonomia: POTS, inappropriate sinus tachycardia (“ITS”), vasovagal
syncope, pure autonomic failure, neurocardiogenic syncope (“NCS”), neutrally-mediated
hypotension (“NMH”), orthostatic hypotension, orthostatic hypertension, autonomic instability,
and lesser-known disorders such as cerebral salt-wasting syndrome. Id. He lists some of the
symptoms of patients with dysautonomia: excessive fatigue; excessive thirst (polydipsia);
lightheadedness, dizziness, or vertigo; anxiety or panic that is not mentally induced; rapid or

                                                65
slow heart rate; orthostatic hypotension sometimes resulting in syncope (fainting); blood
pressure fluctuation; difficulty breathing or swallowing; gastroparesis (delayed gastric emptying)
with associated nausea, acid reflux, and vomiting; and activity- and exercise-induced heat
intolerance. Id. at 2.
         Other symptoms frequently associated with dysautonomia are: headaches, pallor, malaise,
facial flushing, salt craving, mydriasis (abnormal dilation of pupils), constipation, diarrhea,
nausea, acid reflux, visual disturbances, numbness, nerve pain, chest pains, and sometimes loss
of consciousness and seizures. Id. Petitioner was diagnosed with neurocardiogenic syncope,
syncope and dystonia, POTS, gastroparesis, etc. Id. Dr. Steinman counted 17 treating
physicians who acknowledged petitioner had conditions or symptoms consistent with
autoimmune dysautonomia. Id.
        Dr. Steinman chooses to ignore petitioner’s viral illness which she had in early
September 2009 because “we do not know the exact nature of the alleged illness.” Id. at 6. He
continues, “I do not see any objective evidence of an infection, virus or any confirmed
microbiologic diagnosis of a virus or bacteria.” Id. However, even if petitioner did have a virus,
Dr. Steinman says, the virus and the flu vaccine could have acted in combination, meaning the
vaccine would have been a substantial factor, i.e., but for the vaccination, petitioner would never
have had these issues. Id. Dr. Steinman disagrees with Dr. Donofrio that petitioner’s training for
a 5K race was sufficient exertion to cause rhabdomyolysis. Id. Dr. Steinman says that he was
not trying to opine in his initial report that petitioner’s rhabdomyolysis caused her neurological
symptoms, i.e., autoimmune inflammatory neuropathy. Id. at 7.
        Dr. Steinman thinks that his discussion of data concerning GBS in his initial expert report
is relevant to petitioner even though petitioner did not have GBS. Id. His opinion remains that
flu vaccine caused petitioner’s rhabdomyolysis and autoimmune dysautonomia due to an
autoimmune inflammatory neuropathy, i.e., ganglionopathy. Id. at 8.
        On August 14, 2014, petitioner filed two charts Dr. Steinman prepared: (1) Exhibit 93,
entitled “Analysis of Doctors Who Agree Autoimmune Dysautonomia;” listing 20 doctors127
over seven pages, and (2) Exhibit 94, entitled “Symptoms Relevant to Opinion of Autoimmune
Dysautonomia,” listing over 100 symptoms128 on 11 pages. Out of those more than 100

127
    The doctors Dr. Steinman listed on the chart who purportedly agree petitioner has autoimmune dysautonomia are:
Dr. Atiga, Dr. Buttar, Dr. Cintron, Dr. Ghassemi, Dr. Grubb, Dr. Ho, Dr. Naya, Dr. Lyden, Dr. Olek, Dr.
Tannenbaum, Dr. Tang, Dr. Tran, Dr. Urrutia, Dr. Sharrief, Dr. Virmani, Dr. Wallace, Dr. Waxman, Dr. Wilkinson,
Dr. Wohlman, and Dr. Yan-Go. Ex. 93, at 1-7. Only five of these doctors are neurologists: Dr. Cintron, Dr. Lyden,
Dr. Olek, Dr. Sharrief, and Dr. Yan-Go.
128
    The symptoms Dr. Steinman finds relevant to the diagnosis of autoimmune dysautonomia are: syncope, near
syncope, shaking, weakness, dizziness, lightheadedness, increased respiratory rate, cough, fatigue, feeling weak and
tired, rhabdomyolysis, leukocytosis, recurrent respiratory issues, elevated liver function tests, elevated creatine
kinase, heart murmur, shortness of breath, muscle weakness, tingling in hands and feet, passing out while sitting or
standing, fainting or convulsions (sometimes after eating), lower extremity weakness, headaches, neck/joint pains,
generalized tremors, worsening of extremity weakness, difficulty ambulating, easily winded, feeling legs would
buckle from lack of strength, trouble concentrating, stuttering speech, shooting and tingling pains in lower
extremities, walking and performing motor functions for 15 minutes in the morning before tremors would set in,
syncope after meals, hot flashes vs. fever, symptoms such as tremors that did not start right away each morning but

                                                        66
symptoms, Dr. Steinman finds irrelevant to the diagnosis of autoimmune dysautonomia only five
symptoms: hyperventilation, talking in one-word answers, cold symptoms (body aches, sore
throat, not feeling well), pseudoseizures, and cold spots in the back of her head.
        On August 28, 2014, petitioner filed Dr. Steinman’s second supplemental expert report.
Ex. 108. He reiterates that petitioner had autoimmune dysautonomia due to autoimmune
neuropathy as a result of flu vaccination on August 23, 2009. Id. at 1. He states, “Autoimmune
inflammatory neuropathy is also known as Guillain Barre Syndrome.” Id. He observes that
GBS may have autonomic nervous system manifestations. Dr. Steinman then proceeds to
describe the various manifestations of autonomic changes in someone who has GBS. Id. He
states “dysautonomia is a variant of GBS.” Id. at 2. He admits he concludes petitioner had GBS
by “inference,” i.e., he infers since she had autonomic dysfunction, she had GBS. Id.
        On January 13, 2015, respondent filed the expert report of Dr. Eric Lancaster, a
neurologist. Ex. H. Respondent filed Dr. Lancaster’s CV as Exhibit I. Respondent filed an
updated CV of Dr. Lancaster on May 6, 2016. It is dated April 18, 2016. Ex. KKK. He states in
his CV that he has expertise in antibody-mediated neurological disorders. Id. at 1. He is based
in the Center for Autoimmune Neurology at the University of Pennsylvania. Id. He is Assistant

30 minutes after waking up or soon after eating and then being unable to move her limbs, spastic jerking limb
movements, dystonic posturing, jerking movement of the entire body while walking, normal reflexes and strength,
stuttering and halting speech which would disappear upon whispering, inability to hold a cup of water in her hand
without spilling, trouble walking, dysarthria, abnormal gait, ascending bilateral lower leg weakness, dysphonia,
episodes of uncontrollable blinking, inappropriate laughter, photophobia, tinnitus, syncopal episodes associated with
eating, ataxic waddling gait, foot tapping, head bobbing, jerky vertical head tremor varying according to the level of
exertion, ability to walk backward and sideways but not forward without abnormal gait and head bobbing, speech
issues relieved by placing her hand on her chin, touching her anterior left thigh or fastening a belt around her leg to
allow her to walk normally, memory difficulties, concentration difficulties, labored breathing, back to back
seizure/contractures, gross motor deficits, loss of coordination, inability to ambulate, inability to articulate with
dysphonia, absence of fine motor skills, ability to run an 8K race two days prior to rapid deterioration, inability to
keep food down without vomiting, changing speech tones and a foreign accent (British or Australian), easier to
breathe while running than at rest, walking straighter if she looked to the left, heartbeat increasing to 200 while
exercising, symptoms improving with exercise, overheating resulting in syncopal episodes, exercising excessively to
prevent syncope, difficulty walking but no problem running except would sometimes pass out after running,
frequent seizures (about 60 per day) without losing consciousness, difficulty reading, difficulty
recalling/strategizing, trouble with noise/lights which exacerbated her problem with talking and caused stuttering,
loud noises causing seizure, inability to do math, directional confusion, eating making her pass out, arm and face
muscle contractions while speaking, inability to focus on words on a page, inability to read and comprehend,
weakened cognitive skills, stress exacerbating her symptoms, sinus tachycardia, normal heart rate and blood
pressure response to exercise, post-exercise syncope secondary to neurocardiogenic hypotension, unusual form or
neurocardiogenic syncope that improved with exercise because exercise would increase her sympathetic tone, tilt-
table test showing that petitioner’s clinical symptoms were reproduced and worsened in upright tilt position by
provocation with nitroglycerin, Dr. Atiga’s suggestion of cerebral syncope as dysregulation of cerebral blood flow to
upright posture especially with orthostatic stress, not eating or drinking but vomiting and dry heaving, facial
weakness, heat intolerance, postural orthostatic tachycardia syndrome (POTS), postprandial hypotension, poor
exercise tolerance but feeling best when exercising vigorously, SPECT brain scan showing reduction in watershed
bilaterally and decreased perfusion in right thalamus, Raynaud’s of the brain, reaction to central nervous system
anti-depressant drugs and SSRIs, gastrojejunostomy tube, controlling breathing with extreme concentration, tremors
resolving each morning to apply makeup but later unable to speak or move limbs, spastic jerking, dystonic
posturing, uncontrollable blinking, and absence of fine motor skills. Ex. 94, at 1-11. The undersigned is at a loss to
understand why Dr. Steinman included normal reflexes, normal strength, and normal heart rate and blood pressure
responses to exercise as symptoms of autoimmune dysautonomia.

                                                          67
Professor of Neurology at The University of Pennsylvania. Id. He is board certified in
neurology, electrodiagnostic medicine (scoring in the top 10 percent of the examination), and
neuromuscular medicine. Id. at 2. Dr. Lancaster’s thesis for his Ph.D. concerned the physiology
of the autonomic nervous system. Id.
       Dr. Lancaster is a member of the following associations: Society for Neuroscience, the
American Academy of Neurology, and the American Association of Neuromuscular and
Electrodiagnostic Medicine. Id. He has authored or co-authored 32 articles. Id. at 3-5.
         Dr. Lancaster reviewed videos filmed by Generation Rescue (Ex. 58), 20/20 news
reports, and petitioner’s medical records. Ex. H, at 1. Dr. Lancaster notes that on October 17,
2009, petitioner completed the Brain Aneurysm Awareness 8K run in 56 minutes and 13 seconds
(8K is almost 5 miles). Id. at 4. He says the diagnosis of petitioner’s having an abnormal qEEG
done on October 22, 2009 was illogical because it said petitioner had absence epilepsy over one
part of her brain, but absence epilepsy is a genetic condition and would not suddenly occur at
petitioner’s age. Dr. Lancaster does not believe this study validly measured petitioner’s brain.
Id. at 5. Referring to Dr. Buttar’s test conclusion that petitioner had heavy metal poisoning on
October 27, 2009, Dr. Lancaster states it is highly improbable that a single flu vaccination caused
heavy metal poisoning. Id. Moreover, petitioner’s test for mercury was normal just a week
before on October 20, 2009. Id. On November 9, 2009, a news story by vactruth.com reported
that Dr. Buttar had cured petitioner. Id. Dr. Lancaster notes that a similar report appeared on
http://www.ageofautism.com/2009/11/nfl-cheerlreader-disabled-by-2009-flu-shot-on-road-to-
recovery.html. Id.
        Dr. Lancaster notes that on November 18, 2009, Dr. Buttar saw petitioner and recorded
that her cognitive functioning had improved, and she could reportedly read one sentence at a
time but without comprehension. Id. at 5-6. Petitioner had a complex series of speech
symptoms, including losing all speech on November 3, 2009. Id. at 6. Petitioner spoke with an
accent afterward. Dr. Buttar diagnosed her with mercury toxicity and encephalopathy.
Petitioner was on chelation therapy. Id. On December 1, 2009, Dr. Buttar noted petitioner could
not do math or read. Dr. Lancaster does not believe petitioner’s lab results establish Dr. Buttar’s
diagnoses. Id.
        On July 15, 2010, petitioner underwent a tilt-table test. Id. at 7. She was tilted upright
and developed slurred speech progressing to a total inability to speak for more than 15 minutes.
Id. Her blood pressure and heart rate were normal the entire time. Id. at 7-8. When petitioner
was laid flat, her dystonia resolved immediately, but her speech remained slurred for nearly an
hour. Id. at 8. The tilt-table report concludes petitioner had normal heart rate and blood pressure
response. Id. On September 9, 2010, petitioner underwent another tilt-table test. Id.
Petitioner’s blood pressure remained stable, but one data point showed elevated pulse. Her
response to deep breathing was normal. The diagnosis was grade 2 POTS. Id.
       Discussing videos filed into evidence, under the subheading “October 17, 2009 videos,”
Dr. Lancaster describes a video (#00071W.mov) showing petitioner complaining of having no

                                                68
thoughts and speaking in a slow, labored voice. Id. at 11. Dr. Lancaster states this pattern of
speech does not correspond to any neurological disorder in his experience. Id.
       Dr. Lancaster notes in another video (#409_0239_01), petitioner says she cannot drink
water without triggering convulsions. Id. at 12. Dr. Lancaster states this complaint does not
correspond to a neurological disorder in his experience. Id.
        In another video (#409_0240_01), petitioner was preparing to run a race while giving an
interview to channel 5. She reports she cannot talk or walk normally and the only thing she can
do is run. She says when she runs, her voice returns. She wanted to warn people about what was
in vaccines. Id.
        In another video (#409_022_02), petitioner discusses how all her symptoms resolve when
she is running. Id.
        In another video (#409_0245_01), petitioner drinks a large glass of water and eats several
large bites of food very quickly. She has no problem swallowing. Then she immediately drops
her head and has a strained voice. She is assisted to a couch and lies on her side, continuing to
eat and feed herself while jerking her head with her eyes shut. Even with the jerking, she chews
and swallows the food without difficulty. Id. She also demonstrates good fine motor control.
Id. at 13. She begins to suck on a lollipop without difficulty, but then reports it is hard to
breathe. Dr. Lancaster comments that an epileptic seizure with altered consciousness and
generalized shaking would have prevented petitioner from sucking the lollipop. Id.
        Another video (#409_252_01) shows petitioner lying on the couch, being fed while
reporting difficulty moving her tongue. Her then-husband says that petitioner’s moving the food
around with her tongue causes her to seize. Dr. Lancaster notes this is inconsistent with her
claim her tongue is paralyzed. The event appears to Dr. Lancaster to be most consistent with a
psychogenic, non-epileptic seizure-like movement due to bilateral jerking, but preserved
consciousness. Id.
        In another video (#409_254_01), petitioner is lying on her back, speaking with a slurred
pattern, and shaking, which Dr. Lancaster interprets as most consistent with a psychogenic event.
        In another interview (video #409_255_01), petitioner is sitting on a couch and speaking
with a slurred voice again. Id. While she is being interviewed, petitioner has a couple of
episodes of head jerking which her then-husband says are seizures. Petitioner discusses how
prominent her seizures were as an early symptom after vaccination. Occasionally, she speaks
with a British accent. The severity of petitioner’s speech problem fluctuates considerably during
the interview. Petitioner claims she had severe leg weakness and could not walk. Id. In another
video, petitioner continues her interview, and her speech is almost normal. When she whispers,
she has excessive facial movement. She says thinking up words is difficult. She claims reading
can sometimes trigger a seizure. She says that she was angry when someone in the hospital told
her she was crazy. Id.
        Dr. Lancaster describes the next video (#409_0257_02), which is a continuation of
petitioner’s recounting her initial illness, describing seizure-like episodes, ability to walk

                                                 69
backward but not forward, and periods of being able to walk but not talk or talk but not walk.
She says she can relieve vocal problems by putting her hand on her chin. Id. Dr. Lancaster
comments that a real autoimmune brain disease causing neurological deficits would not have
resolution and recurrence within seconds and would not respond to sensory tricks.
       In another video (#409_0257_03), petitioner states all her symptoms immediately recur
when she stops running, which Dr. Lancaster notes is also inconsistent with an autoimmune brain
disease. Petitioner says in the video that she has convulsions and blacking out when she stops
running. Id.
        Under the subheading “October 18, 2009 videos,” Dr. Lancaster describes three videos
(#409_0272_01, #409_0272_02, and #409_0272_03) in which petitioner discusses injuries from
the vaccination while using a computer. Id. at 14. Petitioner speaks in a strained and unusual
way and then sucks on a lollipop, swallowing without apparent difficulty. She also has no
difficulty using her hands to operate the computer, pet her dog, or suck the lollipop. Dr.
Lancaster finds it interesting that petitioner could operate a computer because, in other videos,
she reported profound trouble reading or thinking. Id.
        In another video (#409_0278_01), petitioner is taking liquid medicine from a spoon,
swallowing pills, then drinking liquid several times, all without difficulty. Id. At 4:22 p.m., she
has a non-epileptic (psychogenic) seizure-like event. Dr. Lancaster notes that during the event,
petitioner’s body was shaking but she was able to put her drink down properly. He notes that her
eyes were closed during the event, which he calls a predictive factor for a non-epileptic event.
He comments that petitioner carefully positioned herself to avoid injury during the event. Id.
        In three videos (#409_0278_03, #409_0279_01, and #409_0279_02), petitioner is lying
on a couch and speaking with a slurred voice. Plans are to film her visit to Dr. Buttar’s clinic in
North Carolina. In video #409_0279_01, petitioner’s then-husband is typing on a laptop next to
petitioner and states petitioner learned about sensory tricks on the Mayo Clinic website for
dystonia after a physical therapist mentioned the diagnosis of dystonia. Id.
        In another video (#409_0283_01), petitioner discusses how the back of her head feels
cold and she cannot make it warm. Id. at 15. Later, petitioner reports burning in her neck and
similar burning (“on fire”) while undergoing an MRI. She later explains she believes this
burning is due to her having mercury in her system. She becomes very upset and then has head
shaking while saying repeatedly, “It burns.” Her then-husband helps her lie down, while she
repeatedly says, “It burns,” clenches her fists, and has someone support her jaw. She says the
burning is like “acid in the brain.” Her then-husband says she had periods of two hours of
involuntary laughing. Dr. Lancaster explains that mercury is not paramagnetic and, thus, a
magnetic field from an MRI would not affect her this way, particularly if mercury were dissolved
in the human body. Id.
        In another video (#409_0298_01), petitioner’s then-husband describes petitioner having a
seizure-like event. At Johns Hopkins, she had Ativan and then, when she woke, she spoke
perfectly normally. She later had a miraculous recovery of her strength, doing 20 laps and a little
dance in her room, but then suddenly went into “big time payback seizures.” Id. A physical

                                                 70
therapist thought she had dystonia and mentioned medication and sensory tricks. Id. at 16.
Petitioner seemed to get her speech and walking back with benzodiazepines. She would have
“seizures” with any kind of stimuli, e.g., a dog barking or a plane flying overhead, or if more
than one thing was occurring at a time. She attributed these “seizures” to benzodiazepines. She
spoke to someone on the phone who thought she had an immune problem and that the
benzodiazepines were treating it. Dr. Lancaster comments that there is no medical basis for
opining that benzodiazepines treat an autoimmune disease. Moreover, Dr. Lancaster thought it
extremely unlikely that the events of dog barking or planes flying overhead would trigger
epileptic seizures. His opinion is that petitioner was having psychogenic, non-epileptic events
and not epileptic seizures. Id.
       Another video (#409_0299_01) shows a phone conversation with Dr. Buttar, who had yet
to meet petitioner. He said he wanted to cool her system down and said he could treat it. He
wanted her to come to a controlled environment to get supplements and endorsed hyperbaric
therapy to treat brain inflammation. He endorsed IV fluids, but not IVIG which he thought
would be detrimental. Id.
        Under the subheading “October 19, 2009 videos,” is a video of petitioner arriving at Dr.
Buttar’s clinic. Petitioner is lying down and communicating with gestures, but not talking. Id.
Petitioner has rhythmic head shaking when a nurse asks her a question. Id. at 16-17. Petitioner
covers her face with her hands. Dr. Lancaster comments this does not look like epilepsy but is
another non-epileptic psychogenic event. Id. at 17.
         In another video (#409_0314_01), petitioner’s then-husband and Stan Kurtz discuss how
anything, such as eating or seeing a floor pattern, could trigger petitioner to seize. Dr. Lancaster
states that eating or seeing a floor pattern as a trigger for seizures supports the diagnosis of
psychogenic events rather than epileptic seizures. Id.
        Video #409_0325_01 shows petitioner being spoon-fed. She then stares. Stan Kurtz
says, “She’s seizing.” Petitioner responds somewhat to a hand near her eye and then
hyperventilates a bit when the event stops. Dr. Lancaster comments this event was most
consistent with another psychogenic, non-epileptic event.
        In video #409_0326_01, petitioner makes retching noises but does not vomit. She
clenches her arms and has another shaking event. Dr. Buttar arrives. Petitioner lies on the bed
with her eyes closed as Dr. Buttar speaks. He plans to insert an IV. Stan Kurtz states that when
petitioner is “in this state, any activity can set her off.” She has head shaking after she is asked
to squeeze Dr. Buttar’s hand. Dr. Lancaster comments this is all much more consistent with
psychogenic events than with epilepsy. Id.
       Videos #409_0328_01 and #409_0329_01, show petitioner’s then-husband and Stan
Kurtz putting a wet cloth on petitioner’s head as she lies on a couch without moving. When
asked questions, she shakes her body, but does not answer. Id.
       In another video (#409_0337_01), one of Dr. Buttar’s employees places an electronic
device on petitioner’s neck, talking about electric frequencies in every cell of the body. Dr.

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Lancaster comments he has never seen anything like this and does not know what this device is
supposed to do. Moreover, the process sounded like nonsense to Dr. Lancaster and the testing
method described in the video has no scientific or medical basis. Id.
         In video #409_0338_01, Dr. Buttar explains the results of this test, saying it shows
“lymphatics” and “nutrients.” Dr. Lancaster comments he has never heard of a reliable electrical
test for either lymphatics or nutrients and could not imagine how it would work. Id.
        In four videos (#409_0359_01, #409_0360_01, #409_0360_02, and #409_0360_03), Dr.
Buttar states he is very impressed by how effectively petitioner could advocate for the dangers of
vaccines “like another Jenny McCarthy.” Dr. Buttar sees a connection between petitioner’s
condition and children with autism, which Dr. Buttar thinks vaccines cause. Dr. Buttar and Stan
Kurtz discuss how petitioner could speak for millions of people whom vaccines injured. Id.
        In three videos (#409_0361_01, #409_0361_02, and #409_0362_01), Dr. Buttar
discusses with petitioner several unusual treatments involving her “interference.” Petitioner
speaks to Dr. Buttar in a slow, laborious way. She is connected to an IV which appears to
remove and return her blood. Id. In video #409_0363_01, Dr. Buttar’s staff explains the
machine uses ultraviolet light to kill viruses and bacteria in her blood. Dr. Lancaster comments
that this treatment has no basis in reliable medicine and does not correspond to any accepted
treatment for disease. Moreover, petitioner did not have a bloodstream infection and this method
would not treat one. Id.
       Videos #409_0368_01 and #409_0369_01 show petitioner talking to Dr. Buttar when she
suddenly has jerking of her head when asked to move (something not apparent on a prior video
when she made similar movements). Petitioner puts a hand on her chin and stops the jerking. Id.
        Videos #409_0380_01 and #409_0381_01 show petitioner in a hyperbaric chamber. Id.
at 19. She seems suddenly to have improved speech later in this process. Video #409_0382_01
shows Stan Kurtz saying petitioner spoke very well for three hours after hyperbaric chamber
therapy earlier. The video shows petitioner coming out, communicating by gestures. She
whispers she can wiggle her toes. She whispers she had a seizure just in her toes. Dr. Buttar
plans more therapy with “mist” and “chelators.” Id.
        Under the subheading “October 20, 2009 videos,” video #409_0398_01 shows petitioner
preparing to go into the hyperbaric chamber. Id. She has a headshaking episode. Video
#409_0401_01 shows petitioner speaking normally in the hyperbaric chamber. Petitioner says
she is speaking in her normal voice. She drinks water without difficulty. Id.
       Three videos (#409_0402_01, #409_0403_01, and #409_0404_01) show petitioner
speaking, moving, and eating in the chamber normally. Her then-husband notes excitedly her
remarkable recovery. Id. Video #409_0405_01 shows the hyperbaric chamber being
depressurized. Video #409_0406_01 shows petitioner out of the chamber in a wheelchair.
Video #409_0407_01 shows Stan Kurtz explaining that petitioner worsened immediately as the
chamber depressurized. Id.

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        Video #409_0430_02 shows petitioner communicating only with gestures in Dr. Buttar’s
office. Id. Video #409_0430_03 shows petitioner speaking quietly but normally at first, but
later unclearly. She is carried from the room. Id.
        Three videos (#409_0433_01, #409_0433_02, and #409_0433_03) show petitioner
having a video chat with Jenny McCarthy, in which petitioner speaks normally and describes
how much she has recovered. Id. at 20. Petitioner says she thought she would die when her
tongue paralysis spread to her throat or lungs. She says she could not speak normally because of
tongue paralysis. She states she had burning pain in the MRI machine because of mercury in her
system. Dr. Buttar then explains his theories on mercury toxicity and his treatments. He states
petitioner would not have survived a week without his treatments. He also states the hyperbaric
therapy did not use oxygen, just pressure. Petitioner speaks normally with Dr. Buttar; she eats
and drinks without difficulty. She appears asymptomatic. Dr. Lancaster comments that
petitioner was unaware that mercury is not paramagnetic and therefore the MRI’s magnetic field
would not have affected her. Id.
       In three videos (#409_0434_01, #409_0434_02, and #409_0434_03), petitioner is
speaking on the phone with a normal, clear voice. She drinks without difficulty. Her voice and
movements are normal. She discusses how important it was to have Fairfax Hospital and Johns
Hopkins Hospital to say on camera that flu vaccine caused her symptoms. Id.
        Videos #409_0435_01 and #409_0436_01 show petitioner sitting in a chair, speaking
normally, while getting an IV. Her movements appear entirely normal. She is very enthusiastic
about eating and discusses her immediate recovery with chelation therapy. Id. Video
#409_0437_01 discusses how important it is to get the word out correctly about her recovery.
Video #409_0438_01 shows petitioner standing and moving very well without evidence of her
earlier movement difficulty. Her speech is normal and she seems happy and comfortable.
Videos #409_0439_01 and #409_0442_01 show her planning with Dr. Buttar and Stan Kurtz to
publicize her story. Id.
       Video #409_0446_01 shows petitioner doing various tests of coordination: balancing,
touching her finger to her nose, etc. She does very well on these tests. Video #409_0447_01
shows petitioner sticking out her tongue and waving it to demonstrate good tongue coordination.
She speaks and walks normally. Id.
        Under the heading “October 21, 2009,” video #409_0473_01 shows Stan Kurtz saying
that petitioner’s particular sequence of treatments has never been used before on anyone else. Id.
        Videos #409_0493_01 and #409_0494_01 show petitioner speaking to Dr. Buttar and
then eating a hamburger, performing both activities without any difficulty. Id. at 21.
        Three videos (#409_0514_01, #409_0514_02, and #409_0514_03) show petitioner
resting on a sofa apparently in a hotel room or apartment. She speaks in a low, quiet, unclear
voice and says her symptoms have returned, which she attributes to mercury. Id. She says her
whole body feels hot. Dr. Buttar puts TD-DMPS drops on her arms and asks petitioner to rub

                                               73
her forearms together. She says she cannot and asks Dr. Buttar to rub her forearms for her. Dr.
Buttar says petitioner’s nervous system will pick up this treatment. Id.
        Video #409_0514_04 shows Dr. Buttar continuing to rub petitioner’s forearms together.
He says he thinks the treatment will work quickly, and he applies more drops to her forearms.
Video #409_0514_05 shows Dr. Buttar saying he thinks petitioner is getting better. She then
says, “My tongue is coming back.” Her speech soon returns to normal and she remarks, “that
was really quick.” Dr. Buttar says the cause was mercury. He also mentions viral replication.
Petitioner says her lungs are burning and that this will cause a seizure. Petitioner says, “It is
moving up here” while pointing to her face, and then says, “Forehead.” Her voice is slurred
again. Her voice is back to normal with the next sentence and she states again that the feeling is
moving, while she speaks in a slow, unclear voice. Within seconds, petitioner is normal again.
Id.
        Video #409_0514_06 shows Dr. Buttar administering more of the drops to petitioner. In
videos #409_0516_01 and #409_0516_02, petitioner and Dr. Buttar discuss how many people
have vaccine injuries. In video #409_0517_01, petitioner holds up the bottle of drops to the
camera. The bottle says TD-DMPS. Dr. Lancaster comments that there is no sound scientific
basis to think a chelator can be applied to the forearms in order to treat mercury toxicity. In
addition, a rapid response to these drops emphasizes strongly that petitioner had a psychogenic
illness. Id.
        Under the subheading “October 22, 2009 videos,” video #409_0519_01 shows petitioner
eating food and speaking without any difficulty. Video #409_0520_01 shows petitioner placing
more of the TD-DMPS drops on her forearms and rubbing them together. Id.
       In video #409_0533_01, petitioner is in a car and reports her tongue is numb again. Id.
        Video #409_0546_01 shows someone performing a qEEG on petitioner and discussing
whether the test showed artifact or seizure. Id. The viewer (i.e., Dr. Lancaster) could see the
qEEG partially in the background of the video. The person performing the qEEG states
petitioner’s headshaking event was a diffuse seizure. Id. Dr. Lancaster found this statement
unconvincing because the event looked like muscle artifact that petitioner’s headshaking
triggered. Id. at 21-22. He said an epilepsy specialist could review the entire data of the qEEG
to examine this. Id. at 22. Dr. Ruben Cintron, petitioner’s neurologist who is also board
certified in neuromuscular electromyography (see supra, n.41) did review this qEEG and found it
to be normal (med. recs. Ex. 1, at 14), contrary to the technician Ms. Preston’s conclusion when
petitioner was under Dr. Buttar’s care.
       Video #409_0562_01 shows petitioner speaking normally, then pausing, staring off, and
having head shaking. Then she speaks in a slow, slurred voice. Dr. Lancaster comments this
behavior is most consistent with a psychogenic event. Petitioner returned to her normal voice
and then back to her slurred, strained voice a couple of times within a period of minutes. Id.
       On November 19, 2009, Fox News had a follow-up showing petitioner walking,
laughing, and talking normally after her treatment sessions with Dr. Buttar. Id.

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        Dr. Lancaster then comments on this case. He notes petitioner developed a complex
series of symptoms after receiving flu vaccine on August 23, 2009. She reported a flu-like
illness beginning on September 3, 2009. She then went to the ED of a hospital for
rhabdomyolysis from which she recovered. Dr. Lancaster defines rhabdomyolysis as a
breakdown of muscle fibers with leakage of the muscle enzymes into the blood. There is a risk
of kidney damage if the levels of these proteins in the blood are excessive, but petitioner
recovered with hydration and supportive care. Dr. Lancaster states rhabdomyolysis is self-
limiting and recovery of muscle is generally full. He notes that petitioner manifested full
recovery from rhabdomyolysis by running an 8K race. Ex. H, at 22.
       Dr. Lancaster says there are many causes of rhabdomyolysis, the most common being
substance abuse, exertion, trauma/immobilization/crush injuries, excessive heat, and seizures.
Influenza infection may also cause rhabdomyolysis, but only a very few isolated case reports of
rhabdomyolysis after flu vaccination exist, often in conjunction with other risk factors such as
medications and illness. Id.
        Dr. Lancaster notes that before petitioner had rhabdomyolysis, she was regularly engaged
in distance running and was training for a half-marathon. He states exertion is a common cause
of rhabdomyolysis. Dr. Lancaster’s opinion is that it is more likely that factors other than her flu
vaccination, i.e., running, a viral infection, or other causes, triggered her rhabdomyolysis. In any
event, Dr. Lancaster notes that rhabdomyolysis does not damage the autonomic nervous system
or the central nervous system. Rhabdomyolysis would not explain foreign accent syndrome,
seizure-like events, tongue paralysis, and other symptoms that petitioner reported. Dr. Lancaster
writes he cannot find any logical connection between petitioner’s isolated rhabdomyolysis and
her subsequent symptoms. Id.
        Dr. Lancaster states that from September 17, 2009 to December 2009, multiple
physicians treated petitioner for numerous symptoms which had no physiological basis. Id. at
23. These symptoms persisted into other phases of her illness. Multiple physicians suspected
petitioner had conversion disorder. Dr. Lancaster gives 11 examples of conversion disorder:
       1. On September 17, 2009, petitioner returned to Loudon Hospital, complaining of
          profound weakness and tingling of all four limbs. She appeared initially to be
          profoundly weak, but on physical examination, the treating neurologist found no
          physiological cause for these symptoms. Although she reported having fainted, her
          orthostatic blood pressure measurements were normal.
       2. On September 22, 2009, Dr. Sarfraz A. Chaudhary evaluated petitioner and suspected
          a psychologic cause. He ordered a lumbar puncture, which was normal.
       3. On September 26, 2009, petitioner was admitted to Inova Health System where Dr.
          Mohammad Mannon suspected a psychiatric etiology for her symptoms.
       4. On September 29, 2009, Dr. Paul M. Dellemonache evaluated petitioner for suspected
          conversion disorder. Dr. Dellemonache noted conversion disorder was a diagnosis of
          exclusion.
       5. On October 2, 2009, Dr. Garry Ho evaluated petitioner for MS. He considered
          whether petitioner had conversion disorder or another psychiatric etiology.

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       6. On October 3, 2009, petitioner was admitted to Johns Hopkins Hospital for
           headaches, pain in her face and neck with speaking, intermittent uncontrollable
           blinking, difficulty focusing, chills, sweats, lightheadedness, vivid dreams, and
           difficulty sleeping. Physical examination was notable for elements strongly
           suggesting she had psychogenic illness, such as “give-way” weakness (which Dr.
           Lancaster explains is inconsistent effort during strength testing), odd speech patterns,
           and astasia-abasia (which Dr. Lancaster explains is a wild gait that does not conform
           to any physiological disorder and requires good balance to perform; it is a sign of
           conversion disorder). The attending neurologist Dr. Victor C. Urrutia thought
           petitioner clearly had a strong psychogenic component to her symptoms. He also
           noted that petitioner’s symptoms did not fit a physiological paradigm and that they
           were related to anxiety after her earlier event of rhabdomyolysis.
       7. On October 6, 2009 and October 13, 2009, Dr. Garry Ho again considered diagnosing
           petitioner with conversion disorder.
       8. On December 7, 2009, Dr. Randolph R. Stevenson, a neurologist, noted petitioner had
           a very clear astasia-abasia when walking. Her tremor was highly distractible and
           strongly suggestible. Dr. Stevenson opined petitioner had a very clear functional
           component to the majority of her examination.
       9. On March 16, 2010, Dr. Ruben Cintron, a neurologist who had seen petitioner
           multiple times, thought her symptoms were still bizarre neurologically. Petitioner
           had an accent which fluctuated. She was able to walk sideways but not forward. But
           there was no objective evidence on examination of etiology.
       10. On January 10, 2012, Dr. Patrick Lyden, a neurologist, evaluated petitioner and
           thought she had an unsuspected psychiatric diagnosis, but it was too soon to be sure.
       11. On January 13, 2012, Dr. Lyden saw petitioner again and noted the lack of evidence
           that petitioner had ever had GBS. He also noted the lack of evidence that petitioner
           had hypotension. He described her tilt-table test result as normal although she had
           very unusual symptoms during the test. She had a dystonic and syncopal attack
           during a carotid ultrasound. During physical examination, petitioner had a foreign
           accent for half the examination. Dr. Lyden opined that a number of petitioner’s
           symptoms were embellished. Dr. Lyden thought a good psychologist should see
           petitioner and referred her to Dr. Basian.
Id. at 23-24.
        Dr. Lancaster defines conversion disorder as a psychiatric illness in which symptoms
such as numbness or weakness appear to be neurologic or medical, but they lack a physiological
basis. The cause of these symptoms is a subconscious reaction to stress. Dr. Lancaster
distinguishes conversion disorder from malingering. Patients with conversion disorder are not
consciously aware of what they are manifesting and thus do not voluntarily control it. Common
manifestations of conversion disorder are: psychogenic seizure-like events; bizarre gait; reported
numbness or weakness; events resembling syncope; difficulty swallowing; and tremor. Dr.
Lancaster states persons with conversion disorder may be highly suggestible and stress may
provoke their symptoms. He notes that conversion disorder is common in neurologic clinics. Up

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to 14 percent of patients seeking neurological care do not appear to have a physiological cause of
their symptoms and may have conversion disorder. Particularly common are psychogenic
seizure-like events and a common diagnosis during evaluation of patients who appear to have
epilepsy. Because of the lack of specific diagnostic tests, doctors are cautious about diagnosing
conversion disorder. However, Dr. Lancaster notes that there is a low frequency of patients
initially diagnosed with conversion disorder who have a subsequent medical explanation for their
symptoms. Id.
       Dr. Lancaster opines that the symptoms petitioner displayed between September and
October 2009, as the medical records describe and the videos display, support the diagnosis of
conversion disorder. These symptoms include: periods of speaking with a foreign accent;
unexplained weakness and numbness of her limbs; reported paralysis of her tongue; an unusual
(non-physiological) jerking gait while maintaining her balance; memory complaints; the ability
to walk backward, but not forward; and the ability to run forward but not to walk forward. These
symptoms were inconsistent during the time period of the video displays. For example, Dr.
Lancaster notes that petitioner reported paralysis of her tongue but then she ate and spoke
normally at times. She reported profound cognitive and reading problems, but then would send
e-mail on her computer. She reported profound weakness, but then ran an 8K race. She reported
profound unsteadiness, but never fell regardless of her wild gyrations. Id.
        Dr. Lancaster notes that petitioner underwent MRI, EMG, and lumbar puncture tests, but
they did not show any physiological basis for her symptoms. Dr. Lancaster states it is difficult to
imagine a disorder that would cause all of petitioner’s symptoms without any objective findings
on any of the tests of petitioner’s central and peripheral nervous systems. He recalls that
multiple skilled neurologists thought petitioner’s symptoms were non-physiological. In addition,
the varying severity of the symptoms and the ease and frequency with which they disappeared
and reappeared with sensory tricks and other non-traditional treatment suggest a psychogenic
etiology. Although conversion disorder is a diagnosis of exclusion, Dr. Lancaster notes that
thorough diagnostic testing, including repeated examinations, brain MRIs, and lumbar puncture,
excluded any other plausible cause. He concludes that the most logical explanation of
petitioner’s events in this time frame is conversion disorder. Id.
        He notes that the events in Dr. Rashid Buttar’s office, beginning on October 19, 2009,
strongly support a diagnosis of conversion disorder. Id. In this visit and subsequent ones,
petitioner appeared unable to speak, to have profound cognitive problems and seizure-like
episodes, and to be profoundly weak. Id. at 24-25. Dr. Buttar diagnosed petitioner with mercury
toxicity from her flu vaccination. Id. at 25. At other times, Dr. Buttar mentioned infections,
autoimmunity, and other theories as causative. Dr. Lancaster opines these diagnoses are
implausible. Dr. Buttar administered a series of alternative treatments, including EDTA
(ethylenediaminetetraacetic acid), DMPS (dimercaptopropanesulfonic acid), hyperbaric
chamber, and some sort of nerve stimulation. Id. The videos show petitioner responding
dramatically to multiple different treatments, including the hyperbaric chamber without oxygen,
the chelators, and the TD-DMPS drops that Dr. Buttar placed on her forearms. Dr. Lancaster
says the most likely explanation of these events is conversion disorder with petitioner’s strong

                                                77
response to the suggestion that she would get better with these treatments. For example,
petitioner responded within seconds to minutes of Dr. Buttar’s applying drops to her forearms
with a dramatic recovery of her speech. Dr. Lancaster says it is difficult to imagine any
biological basis for her response. He says the most likely explanation is conversion disorder
responding to suggestion. Id.
        Dr. Lancaster continues by noting subsequent reports, including extensive video and
audio of petitioner on “20/20” (the ABC interview show) and in the videos Dr. Lancaster already
described in his expert report show an apparently psychogenic gait disorder with features of
astasia-abasia. Id. Petitioner would lean forward and lurch wildly while flailing her arms. Dr.
Lancaster notes that this gait requires someone with very good balance to perform it without
falling and is not consistent with dystonia or any other neurological disorder in Dr. Lancaster’s
experience. He says petitioner’s foreign accent syndrome and trouble speaking which she
exhibited during the “20/20” show also seems psychogenic. Dr. Lancaster points out that foreign
accent syndrome has rarely been reported after structural brain injuries, but petitioner has never
had a structural brain injury. Therefore, psychogenic etiology is most likely. Moreover, the
quality of petitioner’s speech problem varies over time. Her voice ranges from being strained,
slurred, staccato, and quiet, to a clear British-sounding accent. Id.
         Dr. Lancaster emphasizes that it is important to note that petitioner’s main symptoms
(gait, speech, psychogenic seizures, tongue paralysis causing trouble eating) during this period of
time have nothing to do with the autonomic nervous system. Id. Petitioner’s ability to run an 8K
race while her symptoms resolved during running demonstrates she has excellent cardiovascular
autonomic function. Moreover, her cardiology work-up was normal. Petitioner’s eating
difficulties reportedly involved tongue movements, not the autonomic aspects of digestion. Dr.
Lancaster notes the dramatic fluctuation of petitioner’s gait symptoms, gait nature, and ability to
run but inability to walk forward argue strongly for a psychogenic gait disorder.
        Similarly, petitioner’s speech problem is most consistent with a psychogenic disorder.
Dr. Lancaster says the sudden resolution of petitioner’s speaking problem as soon as she starts to
run is inconsistent with any neurological disorder and certainly not a neurological disorder with
an autoimmune etiology. Dr. Lancaster’s opinion is that the seizure-like events were
psychogenic non-epileptic seizures. They involved generalized tremulousness and apparent
weakness, but never a fall or convulsion. Petitioner retained the ability to respond during many
of these events. Dr. Lancaster says that her events responded dramatically to treatments that do
not affect epilepsy, such as chelation and hyperbaric chamber without oxygen. Id. Dr. Lancaster
says the video evidence strongly argues against petitioner having autonomic dysfunction at this
time and shows diverse manifestations of conversion disorder. People around her who focused
on her symptoms and proposed various theories for them influenced petitioner’s reported
symptoms. For instance, after hearing about mercury coming from her body, petitioner reported
feeling mercury coming out and affecting in a migratory fashion her chest, mouth, and head. Id.
        Dr. Lancaster recounts that by December 2009, many doctors were evaluating petitioner
for possible autoimmune dysfunction. Ex. H, at 26. He notes the following evaluations from
various doctors from December 2009 to April 2012:

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1. On December 18, 2009, Dr. Mark Tanenbaum, a cardiologist, found petitioner did not
    have cardiac abnormalities. A stress cardiogram showed normal heart rate and blood
    pressure responses to exercise, normal exercise capacity, no arrhythmia, and transient
    syncope post-exercise secondary to neurocardiogenic hypotension. Dr. Lancaster
    says it is unclear whether this represented true or psychogenic syncope. He thinks in
    the overall context of petitioner’s case, a psychogenic cause is more likely.
2. The results of a brain MRI and a brain PET/CT scan were normal.
3. On June 4, 2010, Dr. Zangeneh, an endocrinologist, concluded petitioner’s adrenal,
    thyroid, and other endocrine systems were normal.
4. On July 15, 2010, petitioner underwent a tilt-table test. She was tilted upright and
    developed slurred speech progressing to a total inability to speak over 15 minutes.
    However, blood pressure and heart rate were normal during the entire time.
    Petitioner was laid flat and her dystonia resolved immediately, but her speech
    remained slurred for nearly one hour. The report concluded that petitioner had a
    normal heart rate and blood pressure response to tilt-table testing. Dr. Lancaster says
    this study is strong evidence that petitioner’s speech and language symptoms had
    nothing to do with blood pressure changes or autonomic function at all. He considers
    this description of her symptoms is remarkably similar to her speech problems
    recorded on various videos. Her autonomic function was totally normal, but her
    symptoms were profound.
5. On August 4, 2010 and August 25, 2010, Dr. Frisca Yan-Go, whom Dr. Lancaster
    describes as a very well-respected autonomic specialist, evaluated petitioner and
    concluded petitioner has a very complex symptomatology, many symptoms of which
    Dr. Yan-Go could not explain by a unified disorder. Dr. Yan-Go stated she was
    worried about whether petitioner had some functional overlay and subconscious
    effect of conversion reaction.
6. On August 30, 2010, Dr. Kevin Ghassemi, a gastroenterologist at UCLA, evaluated
    petitioner. She had a test called esophageal manometry and an upper GI series, the
    results of which were normal.
7. On September 9, 2010, petitioner had a repeat tilt-table test. Petitioner’s blood
    pressure did not drop, but there was one data point where she had elevated pulse.
    Petitioner’s response to deep breathing was normal.
8. On September 14, 2010, Dr. Frisca Yan-Go noted petitioner’s GI evaluation did not
    show any true motility problem, and concluded that, overall, this did not point to a
    serious pure autonomic failure or neurodegenerative dysautonomia.
9. On October 15, 2010, Northwest GI associates measured petitioner’s blood pressure
    and pulse over nine times after she ate a meal. The results were within the normal
    range.
10. On December 15, 2010, Dr. Daniel Wilkson, a cardiologist, reviewed petitioner’s
    Holter monitor study, which did not show evidence of arrhythmia. Petitioner did not
    have any pauses or abnormal heart beat to explain her symptoms.
11. On August 12, 2011, a brain SPECT scan showed severe bilateral watershed
    perfusion deficits, which the technician said supported a diagnosis consistent with

                                        79
           lupus or vasculitis, even though, as Dr. Lancaster points out, the medical records do
           not support a diagnosis of lupus or vasculitis. Dr. Lancaster thinks this SPECT scan
           conclusion was a false positive. He notes that petitioner’s subsequent normal brain
           PET scan suggests the SPECT scan interpretation was incorrect.
       12. On March 30, 2012, petitioner underwent a gastric emptying study, which showed
           markedly prolonged gastric emptying. Id. Dr. Lancaster notes that petitioner’s
           medications around this time (April 18, 2012) included Sandostatin, metoclopramide,
           gabapentin, disopyramide, midodrine, fludrocortisone, Depo-Provera, acyclovir,
           cerefolin, and methylprednisolone dose pack (apparently on August 31, 2011), some
           of which could affect gastric motility.
       13. On April 18, 2012, Dr. Daniel Wallace, a rheumatologist, evaluated petitioner and
           reported she felt better after she received IV steroids that Dr. Olek prescribed, but did
           not mention that she improved objectively.
Id. at 26-27.
         Dr. Lancaster concludes from this summary that preponderant evidence suggests
petitioner’s autonomic function was intact. Id. Multiple objective measures of petitioner’s
cardiovascular responses (tilt-table testing) and autonomic GI function (GI series) were
objectively normal. Dr. Yan-Go, whom Dr. Lancaster describes as a specialist in the autonomic
nervous system, did a thorough evaluation of petitioner and did not find evidence of significant
autonomic dysfunction. Dr. Wilkinson, a cardiologist, conducted extensive cardiac monitoring
of petitioner to detect abnormal heart rhythms and did not found any abnormality. Dr. Ghassemi,
a gastroenterologist, did a GI series to evaluate petitioner for failure of autonomic motility of her
GI system and did not find any abnormalities. Northwest GI associates tried to document a post-
prandial, i.e., after eating, drop in blood pressure but instead found petitioner had multiple
normal pulse and blood pressure readings over one hour after she ate a meal. The one abnormal
test result Dr. Lancaster found (the September 9, 2010 tilt-table test) reported a rise in one pulse
measurement after tilting in the context of multiple normal pulse measurements and maintained
blood pressure. Dr. Lancaster notes that petitioner’s response to deep breathing, i.e., another
autonomic cardiovascular measurement, was normal. Petitioner’s medical records did not
document any problem petitioner had with pupillary reactivity or sweating, which are also
autonomic functions.
        Dr. Lancaster sums up that looking at petitioner’s clinical picture and diagnostic
evaluations in toto, he does not think the isolated data point on the September 9, 2010 tilt-table
test provides sufficient evidence that petitioner had any autonomic disorder through the end of
2010. Ex. H, at 27. He notes that petitioner’s profound symptoms on tilt-table testing, including
dystonic posturing and inability to speak normally for almost an hour, occurred even though she
had normal blood pressure and heart rate. He says autonomic failure would cause neurological
symptoms during a tilt-table test only if the test prevented the maintenance of normal blood
pressure, resulting in decreased perfusion of the brain and syncope (passing out) or presyncope
(feeling lightheaded). These symptoms would resolve very quickly, taking seconds to one to two
minutes when the patient returns to the supine position. If petitioner failed to maintain adequate

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blood pressure, her mentation might change due to an autonomic cause, but this change would
not occur during normal pressure. He concludes therefore that dysautonomia would not explain
petitioner’s symptoms during her tilt-table test.
        Dr. Lancaster also explains that petitioner’s rapid expulsion of food from her mouth
during the GI studies is not consistent with autonomic failure. Her earlier studies showed she
has normal GI motility throughout her enteral system once she swallowed food. Autonomic
failure could produce vomiting from a lack of forward motility in the esophagus, stomach, and
intestines. But initiation of swallowing is under voluntary control, not under autonomic control.
Therefore, petitioner’s expulsion of food from her mouth was not due to autonomic failure
during the GI study. Id.
        After Dr. Lancaster watched hours of petitioner’s earlier speech and eating symptoms on
the videos, he concludes that the most likely cause of her symptoms was of the same nature as
her earlier conversion disorder symptoms, i.e., the cause for these symptoms was psychogenic,
not autonomic. Id. He notes that a later GI study on March 30, 2012 showed delayed gastric
emptying, but this result conflicts with the results of prior testing, which he attributes to a false
positive. Id. at 28. But, even if it did prove autonomic GI failure, it occurred many months after
petitioner’s August 23, 2009 flu vaccination and, moreover, petitioner was taking medications
that could have affected her GI motility by March 30, 2012, thus influencing the results of that
GI study.
         Dr. Lancaster states the results of the brain SPECT scan were not diagnostic of a
particular illness. Petitioner’s results on other brain imaging, i.e., PET/CT of the brain, brain
MRI, suggest the results of her SPECT scan were probably a false positive. Dr. Lancaster notes
that if petitioner did have central nervous system vasculitis, he would have expected her to have
a series of cerebral infarctions that would have caused different symptoms and revealed objective
abnormalities on her brain MRI.
        Dr. Lancaster believes Mission Hospital had insufficient evidence to diagnose petitioner
with myasthenia gravis. She tested negative for two antibodies used to diagnose myasthenia
gravis (AChR and MuSK). He notes that 85 percent of myasthenia gravis patients have AChR
antibodies and an additional 5 percent have MuSK antibodies. Dr. Lancaster emphasizes that at
least one of these antibodies is present in the great majority of patients with myasthenia gravis.
To diagnose the remaining seronegative myasthenia gravis patients, electrodiagnostic studies
such as repetitive nerve stimulation and single fiber EMG can support the diagnosis. (At the
time of Dr. Lancaster’s first expert report, petitioner had not taken these tests. But when she did
later on, the results were normal.) Dr. Lancaster concludes that if all these tests are negative,
systemic myasthenia gravis is very unlikely to be the correct diagnosis. Given petitioner’s
previously unexplained neurologic symptoms, which he attributes to conversion disorder, Dr.
Lancaster thinks petitioner’s later symptoms suggesting myasthenia gravis are also due to
conversion disorder. He concludes the evidence in the exhibits is insufficient to diagnose
petitioner with myasthenia gravis.

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        Dr. Lancaster states the autonomic nervous system controls multiple bodily systems,
most of them outside complete conscious control or awareness. Id. The primary systems that the
autonomic nervous system controls, and the consequences of autonomic failure, manifest in: (1)
control of blood pressure/orthostatic hypotension; (2) sweating/anhidrosis; (3) bladder
function/urinary retention; (4) sexual function/sexual dysfunction; and (5) gastrointestinal
motility/dysphagia, regurgitation, bloating, and pain.
        Dr. Lancaster notes that the autonomic nervous system does not control consciousness,
memory, speech, movement, sensation, or gait. A patient who has autonomic failure may have
syncope when assuming an upright posture, but he or she should not have problems with
cognition. A patient may fall from a decrease in blood pressure, but his or her gait should
otherwise be normal. Dr. Lancaster says dysautonomia cannot cause a flailing or wild gait and
cause a difference in the ability to walk forward and backward. He also says that the ability to
run but not to walk forward is inconsistent with autonomic failure. If a person can maintain
blood pressure while running, he or she should be able to maintain it while walking. He notes
running makes greater demands on the autonomic blood pressure control mechanisms than
walking does. Id.
        Dr. Lancaster lists many potential causes of autonomic disease: (1) neurodegenerative
conditions, e.g., Parkinson’s or multisystem atrophy; (2) peripheral neuropathies, e.g., GBS and
many others; (3) Sjögren’s syndrome; (4) paraneoplastic disorders; and (5) autoimmune
ganglionopathies. Id. He states while many types of peripheral neuropathy could affect the
autonomic nerves, GBS is an autoimmune neuropathy that typically causes severe neuropathy
with autonomic dysfunction over a period of days to weeks. Id. at 29. Patients with GBS do not
get autonomic involvement without involvement of non-autonomic nerves. In a study Dr.
Lancaster provided for respondent to file, the primary autonomic finding was tachycardia; no
GBS patient had orthostatic hypotension. Another study of GBS patients had autonomic
symptoms of bradycardia and hypertension, but not GI symptoms. In all the cases, the
autonomic symptoms resolved within six months. Dr. Lancaster states, even though petitioner
did not have GBS, and had problems completely inconsistent with GBS (foreign accent
syndrome, speech problems), the autonomic symptoms she reported are not of the type or
duration of autonomic symptoms seen in GBS patients with GBS-related autonomic dysfunction.
        Dr. Lancaster states that autoimmune autonomic neuropathy, also known as autoimmune
autonomic ganglionopathy (“AAG”), is an autoimmune disorder in which the immune system
targets autonomic ganglia neurons. Id. Unlike GBS, AAG primarily affects only the autonomic
nervous system. Some patients have a receptor on autonomic ganglia called the ganglionic
acetylcholine receptor. AAG patients have severe problems with autonomic function, including:
abnormal lack of pupillary reactivity; fixed heart rate; orthostatic hypotension; anhidrosis; dry
mouth/eyes; sexual dysfunction; urinary dysfunction; and GI dysmotility. When the
autoantibodies are present together with appropriate symptoms, a doctor can make the diagnosis
of AAG confidently. When someone does not have a measurable antibody presence, the
diagnosis of AAG is less likely. Dr. Lancaster says petitioner had no evidence of AAG despite
multiple careful evaluations of pupillary abnormalities, dry mouth/eyes, urinary dysfunction,

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sexual dysfunction, fixed heart rate, or anhidrosis. Her test results of orthostatic hypotension
were normal or unconvincing. Her GI evaluations had mixed results, but the studies done within
a reasonable proximity to her August 23, 2009 flu vaccination were normal. Dr. Lancaster
regards petitioner’s diagnosis of AAG as unlikely for three reasons: (1) her autonomic symptoms
and findings were atypical for AAG; (2) she had many non-autonomic symptoms; and (3) the
only specific diagnostic test for antibodies was negative. Id.
        Dr. Lancaster examines the results of studies of Fluzone vaccine and dysautonomia and
finds a paucity of evidence linking autoimmune autonomic neuropathy with vaccines of any
kind. Id.
        As for temporal interval between the flu vaccination and petitioner’s onset of symptoms,
Dr. Lancaster notes petitioner had an episode of rhabdomyolysis 20 days after vaccination and 9
days after a flu-like illness. Id. at 30. He comments that there are case reports of flu vaccination
followed by rhabdomyolysis, but he considers these case reports insufficient to establish
causation. Dr. Lancaster states that exertion is a more common cause of rhabdomyolysis and a
more likely explanation of petitioner’s symptoms. He considers it unlikely that petitioner’s
rhabdomyolysis was related to her flu vaccination. He notes petitioner recovered from
rhabdomyolysis rapidly and it did not cause her persistent disability. He also notes that her
rhabdomyolysis did not have a logical connection to petitioner’s subsequent symptoms which
petitioner’s expert Dr. Steinman attributes to autoimmune dysautonomia. Id.
        Continuing with his analysis of timing, Dr. Lancaster says petitioner’s neurological
symptoms of numbness, weakness, shaking, cognitive complaints, tongue paralysis, and foreign
accent syndrome began 25 days after she received flu vaccine. He admits that this is a plausible
time frame for a vaccine-induced illness. However, he states no neurological disorder including
autonomic nervous system disorder explains petitioner’s symptoms after extensive work ups. He
attributes her symptoms to conversion disorder. Id.
        Dr. Lancaster notes that petitioner’s doctors did not focus on autonomic symptoms until
2010, which was over three months from her August 23, 2009 flu vaccination. In contrast, from
September to December 2009, petitioner’s primary complaints were speech disruption, reported
weakness, and seizure-like events, which were indicative of central nervous system, not
autonomic nervous system, symptoms. Id. Throughout 2010, the opinion of autonomic experts
such as Dr. Yan-Go was petitioner did not have any significant autonomic dysfunction. The first
apparently abnormal GI study was in 2012, over two years after petitioner’s flu vaccination. He
says that in order to link any autonomic symptoms to petitioner’s August 23, 2009 flu
vaccination, the symptoms would have to be part of a single syndrome with neurologic
symptoms. Dr. Lancaster states petitioner’s theory of the case fails to explain the neurologic
symptoms and focuses just on the later autonomic symptoms. He says her case therefore
involves too long a time frame between the vaccination and her autonomic symptoms. Id.
         Dr. Lancaster finds several logical gaps in petitioner’s proposed chain of causation of
alleged serious autoimmune dysautonomia, a type of inflammatory autoimmune neuropathy,
after flu vaccination, as Dr. Steinman proposed in Exhibit 65. First, Dr. Lancaster says

                                                 83
autonomic failure does not explain many of petitioner’s most prominent symptoms. He says Dr.
Steinman’s diagnosis is therefore incorrect. Secondly, Dr. Lancaster states there is no evidence
that petitioner had autonomic failure in temporal proximity to her flu vaccination. Thirdly, Dr.
Lancaster says petitioner’s clinical history and presentation do not fit the diagnosis of
autoimmune disorders with prominent autonomic symptoms, such as AAG and GBS. Fourthly,
no evidence links Fluzone vaccine to autonomic failure or AAG. Id.
         Dr. Lancaster states that conversion disorder, a non-vaccine related alternate cause of
petitioner’s most prominent symptoms, explains her lurching gait, abnormal movements, spells
of decreased responsiveness, reports of numbness/weakness, foreign accent syndrome, and
periods of speech arrest. Moreover, he says conversion disorder is entirely consistent with the
diverse and fluctuating nature of her symptoms. Id. He continues that conversion disorder
explains petitioner’s response to suggestion and Dr. Buttar’s multiple treatments (hyperbaric
chamber, drops on her forearms, chelation). Id. at 30-31. Dr. Lancaster states he cannot
conceive of a medical illness responding so dramatically to any of these treatments, let alone to
all of them. Id. at 31. Moreover, Dr. Lancaster says the negative findings on MRI studies,
lumbar puncture, nerve conduction studies, and many autonomic tests are entirely consistent with
the diagnosis of conversion disorder. He states, “The only logical diagnosis that could produce
such diverse findings over such a long period of time without leaving objective abnormalities on
these tests is conversion disorder.” Id.
        Dr. Lancaster notes that many of petitioner’s doctors suspected conversion disorder or
another psychiatric cause of petitioner’s symptoms. While some of her doctors agreed with the
diagnosis of autonomic failure, others conducted careful evaluations and did not find any
evidence to support the diagnosis of autonomic failure. Dr. Lancaster as well does not see
evidence that petitioner had autonomic failure in the months following her flu vaccination. Id.
He says, in reviewing all of petitioner’s medical records and the videos filed in the case, he is
struck with how the great majority of petitioner’s symptoms had nothing to do with the
autonomic nervous system. He says that doctors who enunciate a theory of petitioner’s case
focusing on the autonomic nervous system without accounting for petitioner’s symptoms such as
the ability to walk backward or sideways but not forward, unusual jerking movements while
walking, ability to run better than walk, cognitive difficulties, language arrest, and speaking with
a foreign accent have “fundamentally failed to explain the actual cause” of petitioner’s alleged
disability. Id.
        Dr. Lancaster then comments on Dr. Steinman’s expert report (Ex. 65). He says Dr.
Steinman’s theory is that petitioner developed “serious autoimmune dysautonomia, a type of
inflammatory neuropathy,” while dismissing the opinions of doctors at Johns Hopkins Hospital
that petitioner had conversion disorder. Dr. Lancaster thinks the Johns Hopkins doctors are
correct. Multiple treating doctors at different times and in different facilities suspected or
diagnosed petitioner with conversion disorder. Their findings included inconsistencies in
petitioner’s neurological examination (astasia-abasia, speaking with a British accent,
unexplained weakness/numbness, speech arrest) which Dr. Steinman does not explain. Dr.

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Lancaster viewed the extensive symptoms in hours of videos and could arrive at no other
explanation for them except conversion disorder. Ex. H, at 31.
        Dr. Lancaster says Dr. Steinman relied on doctors’ opinions that were not convincing
proof of autonomic dysfunction in order to diagnose autonomic dysfunction himself. Id. In
many of these medical records, Dr. Lancaster states the treaters relied on petitioner’s giving them
her diagnosis without making that diagnosis themselves. Objective testing of petitioner was
mainly negative and Dr. Yan-Go, whom Dr. Lancaster described as the most expert practitioner
of autonomic neuropathy, decided petitioner did not have significant autonomic dysfunction
based on objective findings.
        Dr. Lancaster’s biggest problem with Dr. Steinman’s opinion is that Dr. Steinman fails to
address petitioner’s most serious and disabling symptoms: profound language disturbance
including foreign accent syndrome and periods of inability to speak or walk forward (while
maintaining the ability to walk backward and respond to sensory tricks), ataxia, tremors, and
cognitive complaints. Id. Dr. Lancaster says Dr. Steinman “simply qualifies these symptoms as
‘relevant’ to his diagnosis of autoimmune dysautonomia (Ex. 93).” Id. at 31-32. Dr. Lancaster
notes that petitioner’s symptoms do not pertain to the autonomic nervous system, but instead to
the central nervous system. Id. at 32. He reiterates that Dr. Steinman’s diagnosis based on
autonomic dysfunction ignores the most salient clinical features and does not support Dr.
Steinman’s causation theory because it is not a reliable explanation for petitioner’s symptoms.
       Dr. Lancaster takes exception to Dr. Steinman’s thesis that flu virus, containing a small
peptide fragment similar to a peripheral nerve protein (myelin basic protein) can produce an
autoimmune response to peripheral nerve myelin, causing a demyelinating neuropathy. Dr.
Lancaster has three problems with Dr. Steinman’s thesis:
       (1) Why would this cause only an autonomic neuropathy when most myelin basic protein
           is located in other parts of the nervous system? Myelin basic protein is particularly
           prevalent in peripheral nerve and brain. If Dr. Steinman’s proposed mechanism were
           true, petitioner would have developed GBS with perhaps inflammation of the brain
           and spinal cord. But she did not have GBS.
       (2) The medical records do not show that petitioner has antibodies to myelin basic
           protein.
       (3) People have widely studied autoimmunity to myelin basic protein in the context of
           MS, an autoimmune disease targeting myelin in the central nervous system. Dr.
           Lancaster says MS does not affect the peripheral autonomic nervous system.
           Moreover, petitioner does not have MS. Her brain MRI and lumbar puncture were
           normal. Dr. Lancaster finds Dr. Steinman’s theory a poor explanation for petitioner
           developing autonomic symptoms since the explanation requires hypothetical
           antibodies (antibodies which no doctor ever measured) to do something very different
           from what doctors would expect them to do and to cause a disease with which doctors
           have never associated them.
Id.

                                                85
        Dr. Lancaster notes that Dr. Steinman mentions autonomic dysfunction occurs in many
GBS patients. Dr. Lancaster says it is extremely important to recognize that autonomic
dysfunction occurs in GBS when there is widespread demyelination of other, non-autonomic
nerves resulting in objective weakness, measurable abnormalities on nerve conduction studies,
dropped reflexes, and elevated CSF protein. Dr. Lancaster states petitioner never had any GBS
findings. Although some of her doctors pondered whether she had GBS, petitioner’s preserved
reflexes, normal EMG/NCS, and normal CSF protein ruled out the diagnosis of GBS. Id.
        Dr. Lancaster comments on Dr. Steinman’s analysis of autoimmune autonomic
neuropathy (“AAN”)/ganglionopathy (“AAG”). Dr. Lancaster notes a doctor can confirm a
patient has AAG with a specific autoantibody test, but no one did that test on petitioner. AAG
involves generally persistent, severe, and objectively demonstrated failure of multiple
components of the autonomic nervous system. However, petitioner lacked features of AAG,
such as fixed pupils. Moreover, AAG would not explain foreign language syndrome, gait
problems, ataxia, cognitive disability, and many other symptoms petitioner had which do not
pertain to the autonomic nervous system. Id.
       Dr. Lancaster notes the absence of convincing evidence showing that petitioner’s
symptoms responded to immune therapies. Her symptoms responded very rapidly to Dr.
Buttar’s diverse alternate treatments, but Dr. Lancaster views it as implausible for an
autoimmune disorder to respond so rapidly to any therapy or to treatments such as chelation or
hyperbaric chamber. The evidence does not persuade him that petitioner had autoimmune
autonomic neuropathy or any related unspecified disorder. Id.
        Dr. Lancaster takes issue with Dr. Steinman’s linking autoimmune autonomic
ganglionopathy to flu vaccine. The four studies Dr. Steinman cites do not support his thesis. Id.
One paper relies on an earlier paper which itself does not cite a reference or facts about a specific
case. Id. at 33. The third paper does not discuss vaccines. The fourth paper discusses animal
models but no evidence that AAN occurs in people after flu vaccination or any other vaccination.
Dr. Lancaster states that the specific antigen in AAN is a form of the acetylcholine receptor
present in autonomic ganglia. Dr. Lancaster says if Dr. Steinman’s diagnosis of AAN were
correct, this is problematic for his theory of molecular mimicry. The problem is what component
of flu vaccine mimics or resembles the ganglionic acetylcholine receptor. Dr. Lancaster asks if
there is some other antigen on autonomic ganglia, what is that antigen and how closely does a flu
vaccine component resemble it? Moreover, where is the evidence that any of this is true? Id.
         Dr. Lancaster takes further issue with Dr. Steinman’s first supplemental report (Ex. 92) in
which Dr. Steinman says only 50 percent of patients with presumed autoimmune autonomic
neuropathy have antibodies to the ganglionic acetylcholine receptor. Patients who have those
antibodies have important proof of the autoimmune nature of the disease. Dr. Lancaster cites an
article,129 in which the authors at the Mayo Clinic propose criteria for diagnosing autoimmune
gastric dysmotility: subacute autonomic GI symptoms, a personal or family history of

129
   Eoin P. Flanagan et al., Immunotherapy trial as diagnostic test in evaluating patients with presumed autoimmune
gastrointestinal dysmotility, 26 NEUROGASTROENTEROL MOTIL 1285 (2014). This was filed as Ex. V.

                                                        86
autoimmunity, clear objective proof of autonomic GI dysfunction that objectively improves with
immune therapy. Id. Dr. Lancaster states petitioner did not satisfy these criteria. Id.
        Dr. Lancaster notes that Dr. Steinman thinks the diagnosis of GBS is pertinent in this
case even though petitioner did not have GBS (intact reflexes, normal CSF protein, normal
strength). He says Dr. Steinmann seems to imply that petitioner had a purely autonomic form of
GBS, although there is no objective evidence to support this diagnosis. The doctors who
discussed whether or not petitioner had GBS were not neurologists. Petitioner’s neurologists
rejected the diagnosis of GBS. Id. Dr. Steinman does not address petitioner’s many reported
symptoms (dramatic seizure-like episodes, foreign language syndrome, unusual movement
problems such as only being able to walk backward or sideways) which no dysfunction of the
autonomic nervous system can explain. Id. 33-34.
        Dr. Lancaster says very specific objective diagnostic findings exist to diagnose
myasthenia gravis, such as specific antibody tests (AChR, MuSK) and electrodiagnostic findings
(repetitive nerve stimulation, single fiber EMG). Ex. H, at 34. He notes that petitioner did not
have either of the antibody markers. The records do not support electrophysiological evidence of
myasthenia gravis. In the absence of this evidence, Dr. Lancaster thinks petitioner’s having
myasthenia gravis is unlikely. If she developed myasthenia gravis years after her 2009 flu
vaccination, there was no relationship between the vaccination and her myasthenia gravis. Id.
        Referring to Dr. Steinman’s second supplemental expert report (Ex. 108), Dr. Lancaster
notes that Dr. Steinman mentions the autonomic manifestations of GBS without mentioning they
occur in the context of GBS in the non-autonomic nervous system, i.e., lessened reflexes,
weakness, numbness, abnormal nerve conduction studies, elevated CSF protein, none of which
petitioner had. Id. Dr. Steinman notes that autonomic symptoms of GBS rarely persist, which to
Dr. Lancaster means Dr. Steinman is invoking a purely autonomic form of GBS for which no
reliable diagnostic criteria exist. Dr. Lancaster also says Dr. Steinman’s analysis does not
explain the atypical features petitioner manifested that GBS never causes: dystonia, foreign
accent syndrome, speech arrest, etc. Dr. Lancaster finds Dr. Steinman’s analysis has too many
novel, atypical, or inconsistent elements to be acceptable or medically reliable. Id.
        Referring to Dr. Steinman’s chart entitled “Analysis of Doctors Who Agree Autoimmune
Dysautonomia” (Ex. 93), Dr. Lancaster notes that some of the treating doctors Dr. Steinman cites
clearly do not agree with the diagnosis of autonomic failure. Id. Dr. Lancaster also says that
while other treating doctors mention the diagnosis of autonomic failure, they do not support it
with facts. Dr. Lancaster therefore disagrees with several parts of Dr. Steinman’s chart that
constitutes Ex. 93:
       1. Dr. Lancaster states Dr. Yan-Go did not agree with the diagnosis and thought
          petitioner did not have dysautonomia. Dr. Yan-Go suspected petitioner had
          conversion disorder. On August 25, 2010, Dr. Yan-Go, who is affiliated with UCLA,
          evaluated petitioner and noted petitioner had a very complex symptomatology, much
          of which Dr. Yan-Go could not explain by a unified disorder. Dr. Yan-Go also wrote
          she was worried about whether petitioner had some functional overlay and a

                                              87
            conversion reaction. On September 14, 2010, Dr. Yan-Go wrote she still thought
            overall that petitioner did not have a serious, pure autonomic failure or
            neurodegenerative dysautonomia.
       2.   Dr. Lancaster describes Dr. Buttar’s diagnosis as mercury toxicity from a vaccine.
            He notes Dr. Buttar did not focus on autonomic symptoms. The many hours of video
            of petitioner in Dr. Buttar’s office did not involve autonomic nervous system
            symptoms. In addition, Dr. Buttar’s treatments were inconsistent with Dr. Steinman’s
            theory of causation.
       3.   Dr. Lancaster notes Dr. Atiga did not address and may not have been aware of
            petitioner’s extensive non-autonomic symptoms early in her disease course. Dr.
            Atiga suspected autonomic dysfunction but did not produce support for that
            diagnosis. Dr. Atiga referred petitioner to Dr. Yan-Go for an evaluation of whether
            petitioner had autonomic failure.
       4.   Dr. Lancaster says Dr. Cintron occasionally suspected an autonomic disorder, but
            never proved petitioner had one. Dr. Cintron noted the bizarre nature of petitioner’s
            symptoms and his uncertainty about her diagnosis particularly in light of the lack of
            objective evidence on physical examination about what petitioner’s problem was. Dr.
            Cintron noted her bizarre symptoms of fluctuating accent and ability to walk
            sideways but not forward. Later in his course of analysis, Dr. Cintron proposed focal
            dysregulation of cerebral blood flow to explain petitioner’s case. Dr. Lancaster says
            he could not find any precedent for focal dysregulation of blood flow causing
            someone to walk backward but not forward, to speak in a foreign accent, to have
            seizure-like events, or petitioner’s other neurological symptoms. Dr. Lancaster
            regards Dr. Cintron’s diagnosis of focal dysregulation of cerebral blood flow as
            incorrect.
       5.   Dr. Lancaster states Dr. Ghassemi thought autonomic causes of petitioner’s GI
            symptoms were unlikely. On August 26, 2010, given petitioner’s many non-GI
            symptoms, Dr. Ghassemi ordered a test for GI motility. On August 30, 2010,
            petitioner underwent a gastroesophageal manometry and an upper GI series, both of
            which were normal. Dr. Lancaster says the normal results of these tests confirmed
            Dr. Ghassemi’s earlier suspicion that petitioner’s symptoms were not autonomic.
       6.   Dr. Lancaster notes that Dr. Ho’s diagnosis of dysarthria and stuttering does not
            support a diagnosis of autonomic failure and these symptoms do not result from
            autonomic failure. Although Dr. Steinman cites Dr. Ho’s notation of dystonia as
            supportive of Dr. Steinman’s diagnostic theory, Dr. Lancaster notes that Dr. Ho
            recorded petitioner had been worked up for possible dystonia, but did not himself
            diagnose petitioner with dystonia. Dr. Lancaster also notes that dysautonomia does
            not logically explain dystonia.
Id. at 34-35.
      Referring to Dr. Steinman’s chart entitled “Symptoms Relevant to Opinion of
Autoimmune Dysautonomia” (Ex. 94), Dr. Lancaster notes Dr. Steinman lists a series of
symptoms as being relevant to his diagnosis of autoimmune dysautonomia. Dr. Lancaster states

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he takes a different approach than Dr. Steinman by listing petitioner’s most prominent symptoms
and findings during the few months after petitioner’s vaccination on August 23, 2009. Dr.
Lancaster says petitioner’s treating doctors listed these symptoms in their notes in the end of
2009 and the videos extensively document these symptoms. Dr. Lancaster classifies these
symptoms as either plausibly related or not related to the autonomic nervous system. Id. Of the
16 symptoms130 Dr. Lancaster lists (combining several of them to reach a total less than Dr.
Steinman’s total number of petitioner’s symptoms), only two symptoms are potentially
autonomic but could have many possible causes: (1) lightheadedness, dizziness; and (2)
vomiting, poor GI motility. Id. at 36.
        In conclusion, Dr. Lancaster states petitioner had diverse symptoms after flu vaccination
including rhabdomyolysis, from which she quickly recovered, but her rhabdomyolysis was not
related to her other subsequent symptoms. Id. He continues petitioner later reported symptoms
for which doctors could not find a physiologic cause. These symptoms included numbness and
weakness, fluctuating foreign accent syndrome, periods of speech arrest, seizure-like events,
fluctuating memory difficulties, and a highly abnormal gait (e.g., ability to walk backward or
sideways but not forward, making wildly jerking movements when walking). Later, petitioner
developed periods of lightheadedness and difficulty eating. Id. Months later, petitioner reported
symptoms suggestive of myasthenia gravis, but Dr. Lancaster notes objective evidence does not
support this diagnosis. Id. at 36-37. Dr. Lancaster continues by stating the diagnosis of
autonomic failure does not explain most of petitioner’s symptoms and could not possibly account
for her foreign accent syndrome, memory problems abnormal gait, numbness or weakness. Id. at
37.
        Dr. Lancaster notes that the results of autonomic tests on petitioner conducted within a
reasonable temporal interval after petitioner’s flu vaccination do not support the diagnosis of
autonomic failure. Her only abnormal gastric emptying study was conducted over two years
after the vaccination. Moreover, a well-respected autonomic expert, Dr. Yan-Go, did a thorough
evaluation of petitioner and concluded petitioner’s autonomic function was intact. Id.
        Dr. Lancaster reiterates that petitioner most likely has conversion disorder, which
accounts much better for her most disabling symptoms, i.e., foreign accent syndrome, inability to
walk forward (but ability to walk backward or sideways or to run), seizure-like events, bizarre
gait consistent with astasia-abasia, confusion, and language disruption. He states multiple
treating doctors suspected petitioner has conversion disorder. Dr. Lancaster notes that the
medical records do not support a diagnosis of petitioner having an autoimmune disorder that
would cause autonomic dysfunction, i.e., she did not have GBS or AAN. He continues that
reliable scientific evidence is lacking to associate flu vaccine with a poorly specified autonomic

130
   The 14 symptoms Dr. Lancaster lists as not plausibly related to the autonomic nervous system are: unusual
jerking gait; ability to run but not walk; ability to walk backward or sideways but not forward; tongue paralysis;
limb paralysis; spitting food out of her mouth before swallowing; memory difficulties; confusion; inability to speak,
speech arrest, quiet whispered speech; seizure-like events; unusual postures/dystonia; response to sensory tricks;
prolonged dystonic posturing, speech arrest with tilt-table testing in the setting of normal blood pressure; and
response to chelation therapy, hyperbaric chamber without oxygen, “drops” from Dr. Buttar; and improvement with
exercise. Ex. H, at 35-36.

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dysfunction. Moreover, reliable scientific evidence is lacking that any component of flu vaccine
mimics an antigen specific to the autonomic nervous system. Therefore, Dr. Lancaster concludes
that Dr. Steinman’s proposed logical chain of causation between flu vaccine and petitioner’s
symptoms fails on multiple levels. Id.
        On February 20, 2015, respondent filed the expert report of Dr. J. Lindsay Whitton, a
virologist and immunologist whose practice is devoted to research. Ex. Z. Respondent filed Dr.
Whitton’s CV as Exhibit AA. Dr. Whitton received his M.B. Ch.B. (the United Kingdom
equivalent of an M.D.) in 1979 and his Ph.D. in herpes virus transcription in 1984. Id. at 1. He
is Professor in the Department of Immunology and Microbial Science at Scripps Research
Institute. Id. He is a fellow in the American Academy of Microbiology, elected in 2011, and in
the American Association for the Advancement of Science, elected in 2012. Id. He is a member
of the following associations: American Association of Pathologists, American Association of
Immunologists, American Society of Virology, and American Society of Microbiology. Id. He
is on the editorial boards of the following journals: Journal of Virology, Virology (for which he
is editor), BMC Microbiology (core reviewer), and Molecular Therapy. Id. at 1-2. He declined
becoming editor of the Journal of Virology because he was editor for Virology. Id. at 2. He has
authored or co-authored 185 articles (id. at 2-13); he has had 27 international lab trainees (id. at
19).
       Dr. Whitton describes his role is to evaluate the biological plausibility of the
mechanism(s) that Dr. Steinman uses to explain how flu vaccine could cause petitioner’s signs
and symptoms. Ex. Z, at 1. In the context of that purpose, Dr. Whitton states he has not read all
the medical records but is familiar with the general facts of the case. In assessing Dr. Steinman’s
analysis, Dr. Whitton cautions that he focuses on the disease Dr. Steinman claims petitioner has
but does not necessarily agree that Dr. Steinman’s diagnoses are correct. Id.
       Having read Dr. Steinman’s three expert reports at that point (Exs. 65, 92, and 108), Dr.
Whitton states they lack a consistent and clear explanation for how flu vaccine can cause the
various diseases at issue in this case because Dr. Steinmann invokes essentially the entire
immune system, i.e., innate immunity, T-cells, and other antibodies, yet appears to focus on a
very specific immune response against “HFFK-like amino acid sequences.” Ex. Z, at 2.
       Dr. Whitton summarizes Dr. Steinman’s analysis as follows:
       1. Petitioner developed rhabdomyolysis (Ex. 65, at 1 and elsewhere);
       2. Petitioner developed a form of GBS (Ex. 65, at 9);
       3. Petitioner developed autoimmune autonomic ganglionopathy (“AAG”), resulting in
          autoimmune dysautonomia (Ex. 65, at 1 and elsewhere);
       4. Flu vaccine administered August 23, 2009 caused all of the above (Ex, 65, at 1 and
          elsewhere); and
       5. Molecular mimicry directed against “HFFK-like” amino acid sequences that flu
          vaccine and petitioner’s myelin basic protein (“MBP”) share, which is a component
          of most nerve cells, is the mechanism underlying the above diseases (Ex. 65, at 1, 10-
          15).

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Id.
        Dr. Whitton says he is intimately familiar with the theory of molecular mimicry, having
been a laboratory colleague of Dr. Robert Fujinami in 1984 when he with their shared mentor Dr.
Michael Oldstone popularized the concept of molecular mimicry in an article in the journal
Science. In that article, Drs. Fujinami and Oldstone posited that hepatitis B virus could trigger
an immune response that cross-reacted with a protein in the central nervous system (“CNS”),
causing disease in the host. The central precept of molecular mimicry is that foreign material
must be sufficiently different from the host to break immunologic tolerance, i.e., trigger an
immune response in the person, but also sufficiently similar to allow those immune responses to
cross-react against the person, causing autoimmune disease. Id.
        Dr. Whitton agrees with Dr. Steinman who wrote that molecular mimicry is mainstream
science, pointing to its being an explanation for how early versions of rabies vaccine, made in the
brain tissue of rabbits or suckling mice, and administered for 21 days to humans, could induce
cross-reactive responses, as anti-CNS antibodies, including anti-MBP antibodies, indicated in the
patients’ spinal fluid. Id. at 3. Dr. Whitton notes, however, that molecular mimicry does not
cause many human diseases and, interestingly, the incidence of autoimmune disease has risen in
locales in which infections have become far less frequent. Id.
       Dr. Whitton states Dr. Steinman argues flu vaccine and the host protein MBP share a
short homology, i.e., an HFFK-like motif (Ex. 65, at 10).131 Id. Dr. Steinman contends the
sequence FFKN in flu vaccine triggers an adaptive immune response, i.e., antibodies and T-cells,
to enable the vaccinee, should she encounter flu virus, to fight if off by attacking the equivalent
sequence in the viral protein. Id. at 3-4. But Dr. Steinman argues those antibodies and T-cells
would also attack the HFFK-like sequence in MBP through molecular mimicry, causing
neurological disease. Id. at 4.
        Besides invoking the adaptive immune system, i.e., antibodies and T-cells, Dr. Steinman
invokes the innate immune system constituting a less specific immune response that in general
precedes the adaptive immune response and also contributed to petitioner’s various diseases (Ex.
65, at 16-17). Dr. Whitton writes that, as far as he can tell, Dr. Steinman mentions the innate
immune system in order to discuss molecules called toll-like receptors (“TLRs”) which Dr.
Steinman states are important in GBS. Id. Dr. Whitton notes that one of the articles Dr.
Steinman cites in support of his thesis of molecular mimicry being vital in causing autoimmune
diseases says infections may prevent autoimmune diseases. Thus, Dr. Whitton concludes that the
significance of molecular mimicry in inducing the vast majority of autoimmune diseases remains
highly speculative. Id.
        Dr. Whitton goes through petitioner’s symptoms in discussing her rhabdomyolysis. Ex.
Z, at 5. On September 2, 2009, petitioner developed a sore throat, fevers, and a runny nose (Ex.
22, at 56) and later felt weak and dizzy, causing her to go to Loudon Hospital ED on September

131
   In Exhibit 65, at 10, Dr. Steinman writes, “Influenza viruses, like many other viruses, shares molecular
similarities with one of the major myelin protein[s], myelin basic protein . . . specifically with an HFFK like motif.”
He continues, “The motif FFKN is shared between influenza and myelin basic protein.” Ex. 65, at 11.

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12, 2009 (Ex. 5, at 6). In the days before she was admitted to the hospital on September 12,
2009, petitioner had been doing daily training runs (Ex. 5, at 5). Blood work on September 12,
2009 showed elevated creatine phosphokinase, an enzyme in muscle cells. Its presence in
petitioner’s blood showed she had muscle cell damage over the prior few days. The hospital
discharged petitioner on September 14, 2009 with a diagnosis of mild rhabdomyolysis, i.e.,
destruction of skeletal muscle cells. Dr. Whitton disagrees with Dr. Steinman’s opinion that flu
vaccine on August 23, 2009 caused petitioner’s rhabdomyolysis (Ex. 65, at 1).
        Dr. Whitton is puzzled as to how Dr. Steinman’s theory of molecular mimicry between
HFFK-like sequences applies to flu vaccine causing rhabdomyolysis. Dr. Whitton inquires what
does Dr. Steinman think is the flu vaccine’s proposed target protein, which presumably should be
a protein in skeletal muscle cells. Id. Dr. Whitton asks where is the FFKN sequence that Dr.
Steinman claims the flu vaccine-induced response attacked? Dr. Whitton notes that rather than
explain this lapse, Dr. Steinman cites four articles, but the first involves flu virus and its
relevance is unclear. The second is complicated because the patient was on statins when he
received flu vaccine and rhabdomyolysis is a rare side effect of statins. The third and fourth
papers discuss rhabdomyolysis in association with GBS, an association well-established but
generally with the muscle disease occurring together with or after the onset of GBS’s neurologic
signs and symptoms. Dr. Whitton points out that when petitioner had rhabdomyolysis, she did
not have any neurologic complaints. Her neurologic examination was normal (Ex. 5, at 7 and
10). When she did later complain of neurologic symptoms, Johns Hopkins neurologists
attributed them to anxiety. Id.
         Dr. Whitton gives two alternate explanations for petitioner’s rhabdomyolysis which are
far more likely than the flu vaccine. First, on September 2, 2009, petitioner developed sore
throat, fever, and a runny nose. He states many viruses can cause myositis and rhabdomyolysis.
Secondly, petitioner is an enthusiastic runner and, when she developed rhabdomyolysis, she was
actively training for a 5K race. Dr. Whitton notes that exercise is a known cause of
rhabdomyolysis. He says strenuous exercise most commonly triggers rhabdomyolysis in people
who do not usually exercise, but it can occur unexpectedly even in habitual exercisers. Id.
         Dr. Whitton, without opining whether petitioner had GBS since that is not the purpose of
his expert report, notes that Dr. Steinman’s provision of a Table and Figure on pages 12 and 13
of Exhibit 65 purportedly to show the importance of the FFKN sequence in GBS does not pertain
to GBS, a disease of peripheral nerves, but to MS, a disease of central nerves. Id. at 7.
Moreover, Dr. Whitton notes that Dr. Steinman relies on immune responses to myelin basic
protein, which is not the target of the autoimmune response in GBS. Gangliosides are the target.
Thus Dr. Whitton says Dr. Steinman does not provide a clear hypothesis to explain how flu
vaccine causes GBS generally or in the instant case. Id. Dr. Whitton also notes that Dr.
Steinman on page 11 of Exhibit 65 highlights two specific MBP sequences: HFFK and FFKN.
Id. at 7-8. Dr. Whitton states the more loosely defined Dr. Steinman’s target sequence is, the
more likely it exists by chance in any given protein. Id. at 8.
        Dr. Whitton states that humans have only about 20 different amino acids. The average
protein contains about 500 amino acids, and there are about 30,000 proteins in the human

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genome. Dr. Whitton says it is inevitable that a scientist will find identical sequences and
multiple homologies. Id. Using a protein sequence search engine, Dr. Whitton found 50 human
proteins (including MBP) containing the sequence FFKN. Id. at 9. Thus, the identification of
FFKN or any other short sequence of amino acids in viral proteins and human proteins is
predictable. Id.
        As for Dr. Steinman’s invoking the innate immune system in GBS in his analysis, and the
increase of TLRs in the blood cells of people, Dr. Whitton comments that Dr. Steinman relies on
what Dr. Whitton calls a “dreadful” study as well as a third-rate paper. Id. Dr. Whitton notes
that a wide array of inflammatory stimuli activate TLRs. Id. Moreover, Dr. Whitton points out
that antibodies, not T-cells, mediate GBS, which is why plasma exchange is the primary therapy
for most GBS cases. Id. at 10.
        Moving on to Dr. Steinman’s thesis that vaccines can trigger AAG, Dr. Whitton takes
issue with the papers upon which Dr. Steinman relies in making this statement. Id. Two of the
four papers state vaccination may be associated with (but do not say “cause”) autoimmune
ganglionopathy, without providing support, while the other two papers do not mention
vaccination. Id. Dr. Whitton then asks how Dr. Steinman’s theory of HFFK-like molecular
mimicry applies to AAG. Id. at 11. Dr. Steinman is unclear as to whether innate immunity or
adaptive immunity causes AAG. Dr. Whitton would subscribe to an adaptive immunity analysis
of AAG in which antibodies against acetylcholine receptors are present, but is puzzled why flu
vaccine would trigger their production. If this were so, Dr. Whitton states acetylcholine
receptors would have to contain the FFKN sequence, but there is no evidence that they do or
even that petitioner has antibodies to acetylcholine receptors, for which Dr. Steinman noted
petitioner had not yet been tested (Ex. 65, at 21). Id. Dr. Whitton notes that the ganglionic
AChR antibodies found in many AAG patients recognize a specific subunit of ganglionic AChR
which is a protein that does not contain HFFK. Dr. Whitton asks how Dr. Steinman’s HFFK-like
hypothesis explains how flu vaccine can cause AAG and says that it does not. Id.
         In conclusion, Dr. Whitton says the evidence Dr. Steinman provides to support his
opinion that flu vaccine administered on August 23, 2009 was responsible for petitioner’s signs
and symptoms is extremely weak. Dr. Whitton regards Dr. Steinman’s invocation of molecular
mimicry as implausible whether in the context of rhabdomyolysis, GBS, or AAG. He reiterates
that petitioner’s viral infection (sore throat, etc.) is much more likely than flu vaccine to have
caused her rhabdomyolysis. Id. He notes that exercise could also have been a factor in causing
her rhabdomyolysis. Id. at 12. Dr. Whitton says Dr. Steinman’s molecular mimicry hypothesis
fails to explain how HFFK-like sequences can cause rhabdomyolysis. Dr. Whitton notes that Dr.
Steinman’s focus on an FFKN-driven autoimmune response against MBP in causing GBS is
invalid because gangliosides, not MBP, are GBS’s target. Dr. Whitton criticizes Dr. Steinman’s
use of molecular mimicry between HFFK-like sequences between flu vaccine and human protein
in explaining how flu vaccine caused AAG because the most common target protein in AAG
does not contain HFFK or FFKN. Dr. Whitton concludes that Dr. Steinman’s entire thesis
requires flu vaccine to cause an adaptive, i.e., antibody or T-cell, immune response against

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FFKN, but no one has ever made this finding even though Dr. Whitton says it would be
relatively simple to determine. Id.
        On June 1, 2015, petitioner filed Dr. Steinman’s third supplemental expert report in
which he comments on the videos that Dr. Lancaster reviewed in his expert report, and also
responds to the expert reports of Dr. Lancaster (Ex. H) and Dr. Whitton (Ex. Z). Ex. 118. Dr.
Steinman asserts that petitioner had many symptoms of autoimmune dysautonomia within 10 to
20 days after her August 23, 2009 flu vaccination. Dr. Steinman also asserts that petitioner’s
onset of myasthenia gravis “in hindsight” was about 20 days after that flu vaccination.132 Id. at
1. Dr. Steinman summarizes Dr. Sheean’s medical records and diagnoses, emphasizing that
petitioner’s having received IVIG treatments at the time she was tested for signs of myasthenia
gravis impaired the test results. Id. at 2.
        Dr. Steinman responds to Dr. Whitton’s expert report (Ex. Z) first. Ex. 11, at 4. Dr.
Steinman defends referring to myelin basic protein in patients with GBS. Id. at 6. He criticizes
Dr. Whitton for not being licensed to practice medicine in the United States and for not having
practiced medicine for decades. Id. Dr. Steinman states he will not react to Dr. Whitton’s
assertions about the medical records since Dr. Whitton chose not to read the complete set of
records. Id.
       Dr. Steinman then attacks Dr. Whitton’s opinion that petitioner’s viral illness of early
September 2009 is the more likely cause of her rhabdomyolysis than the August 23, 2009 flu
vaccination based on the ground that the type of viral infection petitioner had is unknown. Id. at
7-8. To support his thesis that an unknown virus cannot be the cause of rhabdomyolysis, Dr.
Steinman quotes verbatim an excerpt from a decision133 10 years ago by another special master
in another case in which that other special master says an unknown virus cannot be an alternate
cause. Id. at 8.
         Dr. Steinman seems unaware that another special master’s decision does not bind the
undersigned. Hanlon v. Sec’y of HHS, 40 Fed. Cl. 625, 630 (1998), aff’d, 191 F.3d 1344 (Fed.
Cir. 1999) (special masters are not bound by their own or other special masters’ decisions, or
those of the Court of Federal Claims, except in the same case). In the almost 28 years of the
undersigned’s experience as a special master, the undersigned has never seen a medical expert
attempt to support his position by citing a legal decision in another case instead of on medical
literature and/or his own experience.

132
    Dr. Steinman’s opinion that petitioner had myasthenia gravis changed over time. At the hearing, he distanced
himself from the diagnosis. Fifteen months after the hearing, petitioner filed an amended petition on September 15,
2017, in which she alleges inter alia that flu vaccine caused her myasthenia gravis, but she follows that statement
with a disclaimer that this is not Dr. Steinman’s “favorite diagnosis” but Dr. Sheean’s diagnosis and Dr. Steinman
puts a “high value” on Dr. Sheean’s opinion. Am. Pet. at ¶ 60.
133
    Torday v. Sec’y of HHS, No. 07-372V, 2009 WL 5196163 (Fed. Cl. Spec. Mstr. Dec. 10, 2009). Dr. Steinman
was petitioner’s neurologic expert in Torday. The issue in Torday was whether petitioner’s flu vaccination or his
preceding upper respiratory illness caused petitioner’s GBS. Dr. Steinman testified that not all viruses cause GBS
which persuaded the then-Chief Special Master to rule the vaccination caused petitioner’s GBS.

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        Dr. Steinman’s point is that a virus whose identity is unknown cannot be considered the
cause of an illness that follows it. The undersigned rejects that point. To accept it would be to
say since the upper respiratory infection petitioner in this case had in early September 2009
before she had rhabdomyolysis is unknown, respondent must prove all upper respiratory
infections can cause rhabdomyolysis or the undersigned cannot find that petitioner’s upper
respiratory illness caused her rhabdomyolysis.
        Dr. Steinman does not insist on such rigid proof for himself in his own expert reports that
petitioner’s flu vaccination caused her rhabdomyolysis. He relies solely on a couple of case
reports, one of which involved someone who was taking a statin, which is itself a risk factor for
rhabdomyolysis. Moreover, Dr. Steinman does not refrain from relying on articles about GBS,
an illness petitioner did not have, as support for his opinion that petitioner had autonomic
nervous system disease based on his “inference” she had GBS despite her normal neurological
test results for GBS. Dr. Steinman is inconsistent in what he demands of respondent’s expert yet
allows for himself. Further in Dr. Steinman’s response to Dr. Whitton’s expert report, Dr.
Steinman engages in a lengthy dispute about Dr. Whitton’s understanding of GBS. But since
petitioner never had GBS, this is not an issue in the case.
         Dr. Steinman then goes on to say that a viral peptide of just five amino acids within a
stretch of 12 amino acids can induce clinical signs of EAE with paralysis in mice. Ex. 118, at
14. EAE is experimental allergic encephalomyelitis.134 Experimental allergic encephalomyelitis
is “an animal model for acute disseminated encephalomyelitis in which the characteristic
pathophysiology and clinical signs of this disease are produced by immunization of an animal
with extracts of brain tissue or with myelin basic protein together with Freund adjuvant; it is
transferable by adoptive transfer of lymphocytes but not by serum.”135 Encephalomyelitis is a
disease involving inflammation of the brain and spinal cord.136 But petitioner never had
inflammation of her brain or spinal cord. Her brain MRIs were normal and her lumbar puncture
showed her CSF (cerebrospinal fluid) was normal. Petitioner is not a mouse. The undersigned
finds it irrelevant that Dr. Steinman can make mice ill with inflammation of their brains and
spinal cords with a mere homology of five amino acids within 12 amino acids, plus Freund
adjuvant, particularly since petitioner did not have GBS, which is a peripheral neuropathy which
does not include inflammation of the brain or spinal cord. Multiple sclerosis, which is Dr.
Steinman’s specialty, does involve inflammation of the brain and spinal cord.
        Dr. Steinman reiterates that there are six amino acids with close structural homology
between flu A hemagglutinin in the 2009 Fluzone vaccine which cross-react with myelin basic
protein. Id. at 15. In answer to Dr. Whitton’s criticism that proof does not exist that flu vaccine
induces a host response to the FFKN sequence, Dr. Steinman protests that absence of evidence
does not mean evidence is absent. Id. at 16. But that is exactly what it means. A protestation

134
    Dorland’s at 586.
135
    Dorland’s at 614. Freund adjuvant is “a water-in-oil emulsion incorporating antigen, in the aqueous phase, into
lightweight paraffin oil with the aid of an emulsifying agent. On injection, this mixture . . . induces strong
persistent antibody formation.” Id. at 32.
136
    Dorland’s at 613.

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that absent evidence does not mean that some time, some place, somewhere, evidence might be
produced. This is speculation. Dr. Steinman is proficient at speculating, but short on proof.
        Turning to Dr. Lancaster’s expert report, Dr. Steinman disagrees that petitioner has
conversion disorder. Id. at 17. Dr. Steinman protests that Dr. Lancaster has not met or treated
petitioner. But then Dr. Lancaster has seen the contemporaneously recorded videos which means
he saw what petitioner was manifesting which is the crux of Dr. Steinman’s diagnosis of
petitioner with autoimmune autonomic neuropathy and autonomic ganglionopathy. It is true that
neither Dr. Lancaster nor Dr. Steinman is petitioner’s treating physician. Dr. Steinman states
there was no triggering event137 for petitioner’s having conversion disorder. He thinks doctors
mistook petitioner’s POTS and myasthenia gravis138 for anxiety.
        Although Dr. Lancaster considers petitioner’s symptoms of profound language
disturbance, including foreign accent syndrome and periods of being unable to speak, inability to
walk forward but ability to walk backward and respond to sensory tricks, reported ataxia,
tremors, and cognitive complaints are localized to the central nervous system, and not to the
autonomic nervous system, Dr. Steinman disagrees. He thinks the inability to walk forward at
times but the ability to walk backward are classic manifestations of certain movement disorders
connected to the autonomic nervous system. Dr. Steinman refers to the “Inside Edition”
interview of petitioner and writes, “It is hard to imagine that someone would concoct these
symptoms, or that it is a conversion disorder.” Id. at 18. Dr. Steinman attributes petitioner’s
foreign accent syndrome to an impairment to the muscles involved with speech that myasthenia
gravis causes. Id. at 19. He thinks her foreign accent is merely the perception of her listeners.
Id.
       Dr. Steinman agrees petitioner did not have classic GBS, but he thinks she had an
inflammatory neuropathy in which dysautonomia is the dominant feature. Id. at 21. Dr.
Steinman cites the Suarez article139 in support of petitioner’s having an inflammatory neuropathy
in which dysautonomia is the dominant feature. He thinks idiopathic autonomic neuropathy is at
one end of the spectrum and GBS is at the other. He agrees with Dr. Lancaster that a specific
autoantibody test for AAG should have been done, but he disagrees that the failure to do this test
means petitioner did not have AAG. Id. Nowhere, except for a brief mention of the “Inside
Edition” video, does Dr. Steinman describe the numerous videos and comments Dr. Lancaster
made concerning them. Only on January 13, 2016 did petitioner file Dr. Steinman’s fourth
supplemental report in which he discusses the videos. Ex. 114.

137
    Dr. Steinman has forgotten that stress can trigger conversion disorder. Dorland’s at 549. See also, Functional
Neurologic Disorders/Conversion Disorder, MAYO CLINIC, https://www.mayoclinic.org/diseases-
conditions/conversion-disorder/symptoms-causes/syc-20355197 (last visited Mar. 1, 2019) (“The cause of functional
neurologic disorders is unknown. The condition may be triggered by a … reaction to stress….”).
138
    Dr. Steinman wrote this report before he decided petitioner’s having myasthenia gravis was not his “favorite”
diagnosis. See Am. Pet. at ¶ 60. At the hearing, he abandoned the diagnosis of myasthenia gravis and just stated
petitioner had autoimmune autonomic neuropathy and vagus nerve injury.
139
    Guillermo A. Suarez et al., Idiopathic Autonomic Neuropathy: Clinical, Neurophysiologic, and Follow-up
Studies on 27 Patients, 1994 NEUROLOGY 1675 (1994); Ex. 132.

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       On September 4, 2015, respondent filed the first supplemental expert reports of Dr.
Lancaster and Dr. Whitton. Exs. RR and SS.
        Dr. Lancaster notes that he reviewed additional exhibits 11-38 including the records of
Dr. Elmer Chang, dated November 2, 2011, who reviewed petitioner’s negative autonomic
studies at UCLA (upper endoscopy, CT of the abdomen and pelvis, gastric emptying study, and
esophageal manometry (Ex. 114, at 1-5)). Ex. RR, at 1. Dr. Lancaster also notes that, on
January 29, 2015, Dr. Sheean saw petitioner and she told him she was taking one Mestinon a
day, which Dr. Lancaster thought unusual because Mestinon lasts only four hours. Id. at 2. Dr.
Lancaster also notes, on February 10, 2015, petitioner had a negative result of a repetitive nerve
stimulation study, involving the ulnar, accessory, radial, and median nerves, at rest and after
exercise to see if she had evidence of a neuromuscular junction disorder (Ex. 116, at 13-18). Id.
at 3.
        Dr. Lancaster emphasizes that myasthenia gravis does not affect sensation, cognition, or
autonomic function. Id. at 4. Patients with myasthenia gravis may have weakness and decreased
muscle tone, but they do not become spastic or have abnormal movements. Dr. Lancaster states
that the likelihood that a patient with generalized myasthenia gravis, as petitioner alleges, would
be negative for MuSK antibodies, negative for AChR antibodies, and have negative repetitive
stimulation studies is about 2 percent. Id. Dr. Lancaster’s opinion is that petitioner’s diagnosis
of myasthenia gravis is very unlikely to be correct, particularly in light of petitioner’s other
symptoms that are very unlikely to have a physiological basis. Id.
         Dr. Lancaster criticizes the chart Dr. Steinman created as a timeline of petitioner’s
symptoms (Ex. 117) purporting to show symptoms of myasthenia gravis or AAN because
petitioner did not have either disease. Id. at 4-5. Dr. Lancaster also criticizes the symptoms Dr.
Steinman attributes to these disorders because they could never reasonably be attributed to them.
Id. at 5. Dr. Lancaster states spastic jerking limb movements are not symptoms of myasthenia
gravis. Dr. Lancaster says spasticity and jerking movements occur due to a central nervous
system disorder, and both involve excessive movements and increased muscle tone. But
myasthenia gravis affects the nerve-muscle junction in the peripheral nervous stem, causing
fatigue, weakness, and in extreme myasthenia gravis, decreased muscle tone. Id. Dr. Lancaster
notes that Dr. Steinman attributes petitioner’s talking in one-word answers to myasthenia gravis,
leading to respiratory failure. But Dr. Lancaster heard petitioner speaking in the videos and
petitioner was not having respiratory failure in them. Her inability to speak occurred while she
was breathing normally. Moreover, Dr. Lancaster found particularly noticeable petitioner’s
dramatic improvement in speech when she started to run a 5K race, which is exactly the opposite
of what someone with myasthenia gravis would experience in which sudden exertion would
worsen shortness of breath and make speaking even harder. Dr. Lancaster notes petitioner’s
apparent foreign accent that could not be due to AAN or myasthenia gravis. Id.
       Dr. Lancaster states that tingling in hands and feet would involve somatic nerves, not
autonomic nerves, and Dr. Steinman should not have attributed those symptoms to AAN.
Moreover, myasthenia gravis does not cause sensory symptoms or affect sensory nerves. Id. Dr.
Lancaster describes petitioner’s difficulty walking during the months after her August 23, 2009

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flu vaccination as consisting of wild lurching movements that actually require excellent balance
to perform. He saw extensive video evidence of petitioner’s gait problem. He labels this
phenomenon astasia-abasia, which is a psychogenic movement disorder and would not occur
with either myasthenia gravis or autoimmune autonomic neuropathy. Id. Dr. Lancaster states
that someone with autoimmune autonomic neuropathy might become lightheaded with exertion
but would not engage in wild, lurching movements, and if the patient did, he or she would find
them more difficult to perform than normal walking. Dr. Lancaster says myasthenia gravis
might cause fatigue, which would result in a patient with that disease walking slowly or needing
to rest frequently, but not engaging in wild lurching movements, which require a lot of energy to
perform. Id. He notes that at the time petitioner performed her most prominent gait symptoms,
she also ran a 5K race, which resulted in sudden resolution of her symptoms with running. Dr.
Lancaster says this would be even more inconsistent with petitioner having AAN or myasthenia
gravis. He says a patient with weakness from myasthenia gravis would not suddenly feel better
with running but would have even worse shortness of breath and need to stop. Id. A patient with
autoimmune autonomic neuropathy causing autonomic dysfunction who became lightheaded
with walking would probably collapse if he or she attempted to run. Id. at 5-6. In autonomic
nervous system disease, a patient can barely maintain adequate blood pressure to perfuse the
brain while walking. Id. at 6. The additional blood flow demands of running would cause
collapse.
        Dr. Lancaster notes Dr. Steinman attributes petitioner’s complaints of shooting, tingling
pains in her lower extremities to both AAN and myasthenia gravis. Dr. Lancaster says
myasthenia gravis causes painless weakness and he would not attribute pain of any kind to
myasthenia gravis. He says AAN affects autonomic ganglia, not pain fibers, and would not
cause pain either. Id.
        Having watched petitioner’s videos, Dr. Lancaster comments that petitioner’s being
unable to move or speak was not attributable to myasthenia gravis. He notes petitioner did not
have any symptoms of myasthenia gravis, e.g., ptosis, weakness, ocular movements, or
respiratory weakness. Petitioner also appeared to have fluctuating consciousness during these
events, also not attributable to myasthenia gravis. A patient in myasthenia gravis crisis to the
extent of not being able to move his or her limbs would typically need to be placed on a
ventilator immediately or he or she would die. Id.
        Dr. Lancaster says that petitioner’s report at Johns Hopkins of lower extremity weakness
and numbness was not due to myasthenia gravis. He notes that myasthenia gravis does not cause
numbness. The weakness in myasthenia gravis is typically bulbar (involving muscles of the face
and neck) more than the limbs and does not ascend. He notes that skilled neurologists at Johns
Hopkins evaluated petitioner and did not think her complaints had a physiological cause and they
did not diagnose her with myasthenia gravis. Id.
       Dr. Lancaster states that Dr. Steinman attributed petitioner’s inappropriate laughter to
autoimmune autonomic neuropathy. Dr. Lancaster questioned how a disorder of the autonomic
nervous system could cause inappropriate laughter. Dr. Lancaster thinks Dr. Steinman’s
statement is implausible. Dr. Lancaster notes that Dr. Steinman incorrectly attributes numerous

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other symptoms to myasthenia gravis: relief of speech symptoms by placing a hand on her chin,
dystonia, foot tapping, head bobbing, improvement of speech with singing, walking better
backward than forward, speaking with a foreign accent, contracting her arm and face when
speaking, etc. Id.
       Dr. Lancaster notes that Dr. Steinman attributes dystonic posturing and apparent dystonic
symptoms to autoimmune autonomic neuropathy. However, dystonia is not a symptom of
autoimmune autonomic neuropathy because dystonia comes from the brain and not from the
autonomic nervous system. In addition, Dr. Lancaster does not think petitioner actually had
dystonia. In summary, Dr. Lancaster states Dr. Steinman’s attribution of petitioner’s numerous
symptoms to autoimmune autonomic neuropathy or myasthenia gravis is illogical and incorrect.
Id.
       Dr. Lancaster states it is unclear to him whether Dr. Steinman is asserting flu vaccine
caused petitioner autoimmune autonomic neuropathy or some other less clearly defined disorder
when Dr. Steinman asserts petitioner has autoimmune dysautonomia due to an autoimmune
inflammatory neuropathy as a result of flu vaccination. Id. at 7.
        Dr. Lancaster takes issue with Dr. Steinman’s assertion that petitioner’s symptoms of
myasthenia gravis began within 20 days of vaccination. Dr. Lancaster says petitioner had
rhabdomyolysis possibly due to an infection or running about 20 days after vaccination and nine
days after a flu-like illness. Then petitioner reported numerous neurologic symptoms, e.g.,
numbness, weakness, shaking, cognitive complaints, tongue paralysis, foreign accent syndrome,
about 25 days post-vaccination. Dr. Lancaster says these symptoms were generally not
symptoms of myasthenia gravis, especially foreign accent syndrome, shaking, and cognitive
complaints. Expert neurologists at Johns Hopkins did not think petitioner had a physiologic
basis for her complaints. From September to December 2009, petitioner’s primary problems
were seizure-like events, speech disruption (generally foreign accent syndrome), and a bizarre
lurching gait that improved with running. Dr. Lancaster notes that petitioner’s videos “provide
abundant evidence of these symptoms,” and he detected nothing in these videos to make
myasthenia gravis a plausible diagnosis. Id.
       Dr. Lancaster notes that from January 2010, petitioner’s symptoms shifted to those
resembling autonomic failure, but that diagnosis has scant objective evidence. Id. He states only
in about 2012 did petitioner have symptoms resembling myasthenia gravis, years after the
vaccination at issue. Even in 2012, objective testing of petitioner for myasthenia gravis was
repeatedly negative and she most likely does not have it. Id.
         Dr. Lancaster says he agrees that Dr. Sheean’s testing and Dr. Gee’s earlier testing in
2012-2013 do not show any objective evidence of myasthenia gravis. Dr. Lancaster does not
agree with Dr. Steinman’s opinion that IVIG treatments might account for petitioner’s negative
test results. He notes petitioner’s testing on two occasions for AChR and MuSK antibodies were
negative. Her repetitive stimulation studies were negative twice as well. He states IVIG might
dilute her immunoglobulins slightly, but there is no evidence and basis to think that IVIG would
result in negative test results. Dr. Lancaster states patients with real autoantibodies have levels at

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an order of magnitude higher than control patients who do not have myasthenia gravis, which
IVIG cannot normalize. Moreover, Dr. Lancaster states IVIG would not normalize petitioner’s
electrophysiology tests. He emphasizes that Dr. Gee tested petitioner when she was not on IVIG
treatments. Dr. Lancaster concludes the most logical reason petitioner tested negative for
myasthenia gravis both before and after she started receiving IVIG is that she did not have
myasthenia gravis. Id.
        Dr. Lancaster disagrees with Dr. Steinman’s theory that a similarity between flu protein
and myelin basic protein underlies petitioner’s symptoms which Dr. Steinman diagnoses as
myasthenia gravis and autoimmune autonomic neuropathy. Ex. RR, at 8. Dr. Lancaster states he
agrees with Dr. Steinman that myelin basic protein is a major component of insulating cells of
both the central and peripheral nervous systems, but autoimmunity to myelin basic protein has
never been demonstrated to be important for the pathophysiology of myasthenia gravis, which
involves autoantigens that are clearly neuromuscular junction proteins on skeletal muscles cells
and do not have significant amounts of myelin basic protein. Id. Therefore, Dr. Lancaster says,
it is implausible that autoimmunity to myelin basic protein would cause myasthenia gravis.
Moreover, Dr. Lancaster states that autoimmunity to myelin basic protein has never been shown
to cause autonomic failure and, therefore, Dr. Steinman’s reliance on an explanation for
autonomic failure based on autoimmunity to myelin basic protein is scientifically unreliable.
The theory of myelin basic protein autoimmunity is most accepted for the model of MS, which is
a completely different disease which fails to explain petitioner’s wide-ranging constellation of
symptoms. Id.
        Dr. Lancaster states petitioner’s preceding viral infection or her running caused her
rhabdomyolysis. He finds the lack of a specific cause for the virus unsurprising due to the
diversity of viral infections. He thinks the flu vaccine is a less likely cause than the viral
infection. He notes petitioner’s rhabdomyolysis was self-limited and cured with appropriate
treatment. It does not explain petitioner’s subsequent diverse symptoms for which no
physiologic cause was established. Id.
        Dr. Lancaster finds interesting Dr. Steinman’s discussion of the animal model of
encephalomyelitis in discussing how molecular mimicry between proteins in flu vaccine and
myelin basic protein may be related to petitioner’s illness. Id. However, if flu vaccine affected
petitioner in this way, she should have had acute disseminated encephalomyelitis (“ADEM”) or
MS, not myasthenia gravis or autonomic autoimmune neuropathy. Id. Regarding Dr.
Steinman’s statement that some autonomic fibers are myelinated, Dr. Lancaster asks why
autoimmunity to myelin basic protein selects autonomic fibers. In Dr. Steinman’s animal model,
this autoimmunity targeted the brain, which has abundant myelin. Autoimmune autonomic
neuropathy is selective for autonomic ganglia because ganglionic AChR (the target antigen) is
selectively expressed in autonomic ganglia. However, Dr. Lancaster says there is no evidence
that autoimmunity to myelin basic protein causes any autonomic or neuromuscular junction
disorder in people. Id.
       Dr. Lancaster notes that Dr. Steinman’s diagnosis of petitioner’s problem has changed
from his initial expert report to include myasthenia gravis and autonomic failure, but they do not

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account for most of petitioner’s symptoms (numbness, foreign accent syndrome, lurching gait,
altered consciousness, paralysis) during the first three months after her flu vaccination. Id. at 8-
9. Now, Dr. Steinman seems to be proposing in Exhibit 118, at 18, that petitioner’s gait is a form
of dystonia, adding a third diagnosis, which is wrong. Id. at 9. Dr. Lancaster says that dystonia
is a central nervous system disorder, directly contradicting Dr. Steinman’s theory that
petitioner’s symptoms are due to myasthenia gravis and autoimmune autonomic neuropathy. Dr.
Lancaster states the autonomic nervous system has nothing to do with dystonia. The autonomic
nervous system controls involuntary processes, e.g., sweating, pupillary constriction, heart rate,
and blood pressure. It does not control complex limb movements or gait. Id.
        Dr. Lancaster asks how does Dr. Steinman prove flu vaccine causes dystonia, now that
Dr. Steinman added dystonia to myasthenia gravis and autoimmune autonomic neuropathy as
diagnostic of petitioner’s disorders? Dr. Lancaster says none of these three diseases is
explainable by hypothetical autoimmunity to myelin basic protein and all three involve distinct
regions of the nervous system. Id. If petitioner had brain lesions, why would she not have MS
and ADEM as well as dystonia?
        Dr. Lancaster says petitioner’s foreign accent syndrome cannot be related to myasthenia
gravis. The video shows petitioner shifting in and out of a British accent with a strong clear
voice. He says myasthenia does not do this. He adds that petitioner’s reported focal paralysis of
her tongue is also not related to myasthenia. Dr. Lancaster says that if petitioner had
autoimmunity to myelin basic protein, she would have peripheral and central nervous system
effects because myelin basic protein is so widespread. She would not have focal autonomic
dysfunction. Id.
         Dr. Lancaster states that the reason no one tested petitioner for antibodies to myelin basic
protein is that they are not useful for diagnosing any neurologic disease. Id. at 10. Dr. Lancaster
criticizes Dr. Steinman’s remark that the proof that petitioner does not have conversion disorder
is her response to treatment (Ex. 118, at 18). Dr. Lancaster says that he personally witnessed
petitioner having a miraculous response from Dr. Buttar’s hyperbaric chamber without oxygen,
chelation, and TD-DMPS drops that Dr. Buttar placed on petitioner’s forearms. He says, “It is
completely implausible that these treatments would affect dystonia, AAN, or MG—let alone cure
all three diseases in a matter of seconds.” Id. His explanation for petitioner’s “cure” is
conversion disorder plus the repeated suggestions that she would respond to these treatments. Id.
         As for Dr. Steinman’s criticism of Dr. Lancaster’s saying petitioner has conversion
disorder because Dr. Lancaster is not a psychiatrist, Dr. Lancaster responds that a neurologist’s
role is to exclude organic etiologies. Dr. Lancaster says he spent many hours reviewing
petitioner’s entire medical record and had the benefit of directly observing petitioner’s symptoms
for many hours on video. The videos were probably the equivalent of 20 typical office visits.
He says there is no plausible physiological basis for petitioner’s most striking symptoms and she
has conversion disorder. Id.
       Dr. Lancaster says petitioner does not have dystonia. He defines dystonia as a movement
disorder characterized by sustained or intermittent muscle contractions causing abnormal tone or

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movements. Id. Initially, petitioner’s symptoms resembled GBS, not dystonia. Id. at 11. But
the Johns Hopkins neurologist concluded that petitioner’s symptoms did not have a physiological
basis. Afterwards, petitioner developed an abnormal gait and unusual speech patterns. He states
a careful review of the videos shows these symptoms were not of dystonia. Dr. Lancaster says
vocal dystonia causes a strained or hoarse voice, not speaking with a British accent. Her
lurching gait is characteristic of a psychogenic movement disorder, not dystonia. Her wild
lurching without falling is characteristic of psychogenic movement disorder. Sudden onset at
maximal severity is also characteristic. Dr. Lancaster notes that petitioner’s movement problem
came about after doctors told her she did not have GBS. These movements faded as her
symptoms focused more on autonomic and apparently myasthenic symptoms. Dr. Lancaster
notes that when confronted by “Inside Edition,” her symptoms suddenly recurred, which is also
characteristic of psychogenic movement disorders. Dr. Lancaster states that petitioner
complained of many symptoms that dystonia does not cause or with which dystonia is not
associated. Id. These symptoms include alteration in consciousness, sensory symptoms
(numbness), profound weakness or paralysis, and speaking with a foreign accent. Id. Dr.
Lancaster says that if petitioner had dystonia, vaccination did not cause it. Most cases of
dystonia have no known cause. Id.
        Dr. Lancaster concludes that the long period of time between vaccination and symptoms
suggestive of myasthenia gravis make vaccination as the cause very unlikely. Id. at 11-12.
Vaccinations do not cause autoimmunity to myelin basic protein, and autoimmunity to myelin
basic protein would not explain focal autonomic failure, myasthenia gravis, or dystonia. Id. at
12. He states vaccination did not cause petitioner’s symptoms. Id.
        Dr. Whitton notes in his supplemental expert report (Ex. SS) that he obtained a Ph.D.
after his medical degree, and he pursued a career specializing in virology and immunology. Ex.
SS, at 1. He has received five National Institute of Health grants to focus on viruses,
immunology, and disease. Id. at 2. Dr. Whitton states that Dr. Steinman failed to address many
of the questions Dr. Whitton raised in his first expert report (Ex. Z). Ex. SS, at 2. Dr. Whitton
says that Dr. Steinman identifies the proposed cellular target for rhabdomyolysis as nerve cells
(Ex. 118, at 5). Ex. SS, at 3. Dr. Whitton notes if nerve damage caused the death of muscle cells
in rhabdomyolysis, petitioner should have had preceding or concurrent neurologic signs and
symptoms, but petitioner’s neurological examination was normal (Ex. 5, at 7 and 10).
        As for Dr. Steinman’s position that petitioner’s preceding viral infection does not count
as a cause of her rhabdomyolysis because no one knows the identity of the viral infection, Dr.
Whitton responds that doctors do not identify the great majority of viral infections. Id. Dr.
Whitton notes that the risk of GBS increases after undiagnosed infections. Id. As for Dr.
Steinman’s position that exercise could not explain petitioner’s rhabdomyolysis because she is an
experienced runner, Dr. Whitton reiterates there is a case report in which an experienced runner,
after a minor change in her training routine, came down with rhabdomyolysis. Id. at 4. Dr.
Whitton states that notably absent from Dr. Steinman’s response is evidence that flu vaccine can
cause rhabdomyolysis. Id.

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        Dr. Whitton takes issue with Dr. Steinman’s contention that myelin basic protein is an
important target in GBS because Dr. Steinman relies on an article that is over three decades old
in support of that proposition. Id. To disprove Dr. Steinman’s new claim (Ex. 118, at 14) that
the peptide sequence FYKNLI (in Fluzone vaccine) is homologous to the sequence FFKNIV in
myelin basic protein and, thus, the immune system sees the F and Y amino acids as mimics, Dr.
Whitton looked at the data from Dr. Steinman’s laboratory and found that if someone takes a
peptide with the FFKN motif and replaces either of the Fs with a Y, antibodies can no longer see
the peptide efficiently. Id. at 4-5. Thus, because the FFK core amino acids are missing from the
flu peptide sequence of FYKNLI in Fluzone vaccine, the antibodies would not efficiently
recognize them and would not be a compelling molecular mimic of the sequence FFKNIV in
myelin basic protein. Id. at 6-7.
        Dr. Whitton notes that Dr. Steinman has still not explained how he thinks flu vaccine
causes AAG. Id. Dr. Steinman admits that the HFFK-like motif has nothing to do with
producing antibodies against acetylcholine receptors. Id. at 9. Dr. Whitton characterizes Dr.
Steinman’s theories as “jumbled.” Id. at 10. Dr. Whitton asks if Dr. Steinman’s “current”
hypothesis is that flu vaccine triggered two completely distinct sets of molecular mimicking
responses. The FYKNLI in flu vaccine induced one response which hypothetically cross-reacted
with the FFKNIV sequence in myelin basic protein, even though, as Dr. Steinman published, the
F to Y difference dramatically altered any potential cross-reactivity of the two sequences.
Supposedly, this imagined cross-reactive response would have caused both rhabdomyolysis and
GBS even though myelin basic protein is not an important target antigen in GBS. Moreover, Dr.
Whitton asks if Dr. Steinman is proposing that flu vaccine induced a second, completely
different immune response, which an unidentified sequence in flu vaccine induced and which
then cross-reacted with an unidentified protein on nerve cells (either AChR or something in
myelin) to cause AAG? Dr. Whitton says he does not understand what hypotheses Dr. Steinman
is proposing. Id.
        On January 13, 2016, petitioner filed Dr. Steinman’s fourth supplemental expert report.
Ex. 141. In the first 20 pages of Exhibit 41, he responds to Dr. Whitton’s supplemental expert
report (Ex. SS). In the last six pages, he responds to Dr. Lancaster’s comments on videos dated
October 17-22, 2009 (Ex. H). Dr. Steinman lists the cases in which he and Dr. Whitton have
debated at hearing the merits of Dr. Steinman’s thesis that HFFKNIV is a molecular mimic. Dr.
Steinman mentions that a number of cases have settled and states, “I have no idea of the impact
of my expanded analysis in the strategic decision to settle, but it certainly appears that
Respondent is aware of much that I shall present here.” Ex. 141, at 1. Dr. Steinman devotes the
next two pages to his many disagreements with Dr. Whitton, indicative of a long history of
professional feuding.
        Dr. Steinman then reveals a “remarkable” feature of the Fluzone vaccine petitioner
received in 2009, i.e., it contains H1N1 viruses capable of eliciting anti-ganglioside antibodies,
one of the known antibodies with which some forms of GBS are associated. Id. at 6. Dr.
Steinman concludes that petitioner’s 2009 flu vaccination not only had a component capable of
inducing anti-myelin basic protein antibodies, but also anti-ganglioside antibodies. All of Dr.

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Steinman’s discussion in this section of his report assumes petitioner had GBS. But the fact that
flu vaccine can cause GBS does not mean it did cause GBS in this case if petitioner did not have
GBS. In response to a question in one of the undersigned’s orders whether Dr. Steinman thinks
petitioner has idiopathic torsion dystonia (dystonia musculorum deformans), Dr. Steinman
replies petitioner has both autoimmune dysautonomia due to autoimmune autonomic neuropathy
and myasthenia gravis. Id. at 20-21. He notes dysautonomia also appears in myasthenia gravis.
Id. at 21.
       Dr. Steinman then proceeds to comment on videos dated October 17-22, 2009 upon
which Dr. Lancaster commented in Exhibit H, which respondent filed one year earlier on January
13, 2015.
       For the October 17, 2009 video (#409_0239_01), petitioner was preparing to run a race
and reported she could not drink water without triggering convulsions. Dr. Lancaster states in
his expert report that this does not correspond to a neurological disorder in his experience. Dr.
Steinman comments he has not heard of this in his experience either. He interprets petitioner’s
statement as manifesting clear dysarthria, i.e., drinking involves muscles needed for speech and
swallowing and, therefore, drinking water worsened petitioner’s muscle weakness in her neck,
causing her head to shake. Id.
        In another video (#409_252_01), petitioner is lying on a couch being fed during an attack
and reporting difficulty moving her tongue. Her then-husband discusses how moving food
around with her tongue causes her to seize. Id. Dr. Lancaster states this is inconsistent with
petitioner’s claim that her tongue is paralyzed and appears most consistent with a psychogenic,
non-epileptic seizure-like movement because she was jerking bilaterally while remaining
conscious. Id. at 21-22. Dr. Steinman says he cannot comment because he would need a
concomitant EEG and the best would be a video EEG. Id. at 22.
        In another video (#409_254_01), petitioner is lying on her back and speaking with a
slurred speech pattern while shaking. Dr. Lancaster considers this most consistent with a
psychogenic disorder. Dr. Steinman says he cannot comment because he would need a
concomitant EEG and video monitoring. Id.
         In another video (#409_0257_02), petitioner continues to relate the story of her initial
illness, describing seizure-like episodes, being able to walk backward but not forward, being able
to walk but not talk at times or talk but not walk at other times. Id. She also describes relieving
vocal symptoms by putting her hand on her chin. Dr. Lancaster comments this is inconsistent
with Dr. Steinman’s theory that an autoimmune condition caused petitioner’s symptoms because
a real autoimmune brain disease causing neurologic deficits would not resolve and recur within a
period of seconds and would not respond to sensory tricks. Dr. Steinman comments that cues
can modulate successfully neurologic deficits whether autoimmunity triggered them or not, and
that a patient can learn from experience. Id.
        In another video (#409_0257_03), petitioner explains how all her symptoms resolve
when she runs, but all her symptoms immediately recur when she stops running. Dr. Lancaster
says this is inconsistent with an autoimmune brain disease. Petitioner also reports convulsions

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and blacking out when she stops running. Dr. Steinman comments, “It is good to listen to the
patient, but I find it difficult to integrate these comments with symptoms.” He also reiterates he
would like to see this when petitioner has concomitant video and EEG monitoring. Id.
         For the October 18, 2009 video (#409_0278_01), petitioner is taking some kind of liquid
medicine from a spoon, then swallowing pills, and then drinking liquid several times, all without
difficulty. Id. At 4:22 p.m., she has a non-epileptic seizure-like event, which Dr. Lancaster
depicts as a psychogenic seizure. During the event, her body shakes but Dr. Lancaster notes she
is able to put her drink down properly. Then she closes her eyes, which Dr. Lancaster says is a
predictive factor for a non-epileptic event. Id. Dr. Lancaster also notes that petitioner carefully
positions herself to avoid injury during the event. Id. at 22-23. Dr. Steinman’s only comment is,
“I would like to see all these activities during concomitant EEG monitoring.” Id. at 23.
        In another video (#409_0298_01), petitioner’s then-husband describes petitioner as
having a seizure-like event and describes her episode of rhabdomyolysis, then losing the ability
to move or speak, and her suspected GBS. He says petitioner’s team of doctors were stumped
and later she could whisper, but not talk, which the neurologists could not explain. He says two
psychologists saw petitioner for one hour and she was discharged from Fairfax Hospital and
went to Johns Hopkins and told the doctors there that her diagnosis was GBS. Johns Hopkins
gave petitioner Ativan and when she woke, she spoke perfectly normally. She later had a
miraculous recovery of her strength, doing 20 laps and a little dance in her room, but then went
into what her then-husband described as bigtime seizures. A physical therapist examined
petitioner and thought she had dystonia, telling petitioner of medication and sensory tricks.
Petitioner was discharged with instructions to follow up with a therapist and seemed to get her
speech and walking ability back with benzodiazepine. He says she would have seizures if she
had any stimuli such as a dog barking or a plane flying overhead, or if more than one thing was
going on at a time. Her seizures were attributed to the benzodiazepines. Petitioner and her then-
husband spoke on the phone with someone who thought her problem was autoimmune and that
benzodiazepines were treating her autoimmune disease. Dr. Lancaster says the idea that
benzodiazepine would treat an autoimmune disease has no medical basis. He also says that these
so-called triggering events for epileptic seizures are extremely unlikely. Dr. Lancaster views
these events as psychogenic and non-epileptic, and not as epileptic seizures. Dr. Steinman’s
comment is his familiar, “I would need to see an objective situation with EEG monitoring and
video in order to analyze the events.” Id.
       Dr. Steinman then states his view on all these videos: “In general for all the discussions
and video sessions, my inclination is to watch and listen thoughtfully, but really I would need
more objective evidence with EEG and video in order to make any pronouncements.” Id.
        Dr. Steinman then moves onto the videos taken October 19, 2009. Video #409_0313_01
depicts petitioner arriving at Dr. Buttar’s clinic, lying down in the clinic and communicating with
gestures, but not talking. Id. Stan Kurtz thinks petitioner should not speak and they should carry
petitioner. Id. at 23-24. Petitioner has rhythmic head shaking when a nurse asks her a question.
Id. at 24. She covers her face with her hands. Dr. Lancaster comments this did not look like
epilepsy but as another non-epileptic psychogenic event. Dr. Steinman continues his refrain:

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“My inclination is to watch and listen thoughtfully, but really I would need more objective
evidence with EEG and video in order to make any pronouncements.”
        In another video (#409_0318_01), petitioner’s then-husband and Stan Kurtz discuss how
anything, e.g., eating or seeing a floor pattern, can trigger a seizure in petitioner. Petitioner feels
the blood move from her head down to her stomach when she eats. They think she is too ill to
answer questions. Dr. Lancaster comments that the fact that eating or a floor pattern can trigger
these events is another factor supporting his diagnosis of psychogenic events rather than epileptic
seizures. Id. Dr. Steinman repeats his mantra: “My inclination is to watch and listen
thoughtfully, but really I would need more objective evidence with EEG and video in order to
make any pronouncements.”
        In another video (#409_0325_01), petitioner receives food by spoon, then stares and Stan
Kurtz says, “She’s seizing.” Petitioner responds somewhat to stimuli (such as a hand near her
eye) and then hyperventilates a bit when the event stops. Dr. Lancaster says this event is most
consistent with another psychogenic, non-epileptic event. Petitioner retches but does not appear
to be actually vomiting. Dr. Steinman repeats his mantra: “My inclination is to watch and listen
thoughtfully, but really I would need more objective evidence with EEG and video in order to
make any pronouncements.” Id.
         In another video (#409_0326_01), petitioner makes more retching noises but does not
apparently vomit. She clenches her arms and has another shaking event. Dr. Buttar arrives and
petitioner lies on the bed with her eyes closed as Dr. Buttar speaks. Dr. Buttar plans to insert an
IV, but Stan Kurtz says that when petitioner “is in this state any activity can set her off.” He
gives as examples a rug pattern, making eye contact, or hearing two voices at the same time.
Petitioner has head shaking after she squeezes Dr. Buttar’s hand on request. Dr. Lancaster says
this is all much more consistent with psychogenic events than with epilepsy. Dr. Steinman
repeats his mantra: “My inclination is to watch and listen thoughtfully, but really I would need
more objective evidence with EEG and video in order to make any pronouncements.” Id.
       In another video (#409_0346_01), petitioner is being transferred to a wheelchair and
retching. She also had rhythmic head shaking during this while her eyes are closed. Id. at 25.
Nevertheless, Dr. Steinman repeats his mantra: “My inclination is to watch and listen
thoughtfully, but really I would need more objective evidence with EEG and video in order to
make any pronouncements.” Id.
         In another video (#409_0382_01), Stan Kurtz reports that petitioner spoke very well for
three hours after earlier hyperbaric chamber therapy. Stan Kurtz says the hyperbaric therapy
makes petitioner speak normally. The video shows petitioner out from the chamber
communicating with gestures. She whispers in a very normal voice that she can wiggle her toes
and states in a whisper that she had a seizure just in her toes. Dr. Buttar plans more therapy with
mist and chelators. Id. Dr. Steinman comments, “I myself am quite skeptical about hyperbaric
therapy and chelators.” Id. He repeats his mantra by saying “my inclination is to watch and
listen thoughtfully, but really I would need more objective evidence with EEG and video in order
to make any pronouncements.” Id.

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       In another video (#409_0401_01), petitioner speaks normally while in the hyperbaric
chamber. She reports she is speaking normally and she drinks water without difficulty. Dr.
Steinman comments with the exact comment he made before about his skepticism about
hyperbaric therapy and chelators, but his inclination is to “watch and listen thoughtfully” and he
needs to have “more objective evidence with EEG and video.”
       Dr. Steinman moves on to videos dated October 22, 2009. In videos #409_0541_01,
#409_0542_01, and #409_0544_01, petitioner has electrodes placed on her head for a qEEG. Id.
He agreed with Dr. Lancaster that an epilepsy specialist should review the entire data of the
study. Id. at 26. He admits he is not a board certified EEG specialist.
        In all, whereas Dr. Lancaster in Exhibit H, at 11-21, describes and comments upon 178
videos, Dr. Steinman in Exhibit 141, at 21-25, describes and comments upon only 17 videos.
Most of his comments on these videos is that he would watch and listen thoughtfully, and he
could not make any other comment until he had more objective evidence with EEG and video
monitoring. He ignores the fact that petitioner has had numerous EEGs, all of which were
normal.
        Dr. Steinman concludes that none of petitioner’s doctors excluded the diagnosis of
autoimmune dysautonomia due to autoimmune autonomic neuropathy or of myasthenia gravis
and, therefore, she cannot have a conversion disorder. Id.
        On June 20, 2016 (which was after the hearing held on June 14-17, 2016), the
undersigned issued an Order that Dr. Steinman and Dr. Whitton give their opinion on whether
the negative test for flu A and B virus antigen on September 12, 2009 means the flu vaccination
petitioner received on August 23, 2009 was ineffective and whether that affected their expert
opinions.
        On July 14, 2016, respondent filed Dr. Whitton’s second supplemental expert report. Ex.
YYY. Dr. Whitton states that the goal of testing for viral antigens is to determine if a patient had
a current viral infection. Id. at 1. The medical records show that on September 2, 2009,
petitioner had a sore throat, fever, and a runny nose. On September 12, 2009, she went to
Loudon Hospital ER where she was diagnosed with rhabdomyolysis. Since viral infections quite
commonly cause rhabdomyolysis, the doctor did a throat swab to look for streptococcal
infection, and a nasopharyngeal wash to look for the presence of flu virus (Ex. 51, at 138). Both
tests were negative. Id. The way to test for the effectiveness of a vaccine is to look for
pathogen-specific antibodies with a blood draw. Also, a doctor would test for pathogen-specific
T-cells with a blood draw. Id. Thus, to test for a vaccine’s effectiveness, a doctor would not
look for antigens; instead the doctor would look for antibody and T-cell responses to antigen. Id.
at 2. Therefore, petitioner’s negative testing for flu A and B virus antigen on September 12,
2009 did not mean the flu vaccination petitioner received was ineffective. Id. She was never
tested for its effectiveness. Id. Dr. Whitton stated his opinion on the case has not changed. Id.
      On July 14, 2016, petitioner filed Dr. Steinman’s fifth supplemental expert report. Ex.
181. His opinion is similar to Dr. Whitton’s and his opinion remains unchanged. Id. at 1.

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         On October 14, 2016, after petitioner filed the medical records of MedStar Georgetown
University Hospital (Ex. 180) where the EMTs took petitioner on June 15, 2016 when she sank
to the floor while growling during the hearing, petitioner filed Dr. Steinman’s sixth supplemental
expert report. Ex. 191. Dr. Steinman states petitioner was making loud inspiratory noises from
the seating area while he was in court. Id. at 1. He heard and observed her inspiratory stridor.
Petitioner wrote on a pad her medication for myasthenia gravis, i.e., Mestinon, after Dr.
Steinman asked if she took the medicine. Dr. Steinman states he was at petitioner’s side during
the 16 minutes it took for the paramedics to arrive, but Dr. Lancaster “did not offer any
assistance.” Id. This is a cheap shot. None of the doctors in the room moved to assist petitioner
when she sank to the floor while growling. The undersigned instructed Dr. Steinman to attend to
petitioner since he was her expert. Only then did Dr. Steinman get up from his chair to assist
her. There was no need for Dr. Lancaster to offer any further assistance.
        Dr. Steinman then pastes into his sixth supplemental expert report the neurological record
from MedStar Georgetown and stresses the importance of the mention at Ex. 183,140 at 5, of
petitioner having ptosis. Ex. 191, at 2. He writes ptosis is a manifestation of myasthenia gravis
and states it cannot be faked. However, Dr. Steinman failed to paste into his sixth supplemental
expert report the further comment of Dr. Brian Barry, the neurologist, on the same page (Ex.
183, at 5), stating that petitioner had bilateral mild to moderate ptosis which could be overcome
spontaneously with upgaze, and which was not worse with fatigue.
        Dr. Steinman comments on the finding of an elevated anti-GAD antibody. Ex. 191, at 8.
Dr. Steinman states he has studied and published on GAD itself and anti-GAD antibodies in type
1 diabetes and multiple sclerosis. He says anti-GAD antibodies have been reported in conditions
that include dystonia and neuromyotonia.141 He cites three references142 and says petitioner has
elements of what these references describe, referring to petitioner’s “quite extraordinary
neurologic functions.” Id. Dr. Steinman says petitioner’s anti-GAD antibodies are “profoundly
important in unraveling her case.” Id. He ran a BLAST search for homologies between GAD
and elements of the 2009 Fluzone vaccine whose components are: A/Brisbane/59/2007 (H1N1)-
like virus, A/Brisbane/10/2007 (H3N2)-like virus, and B/Brisbane/60/2008-like virus. Id. He
says he found a “remarkable” molecular mimic between the A/Brisbane/10/2007 (H3N2)-like
virus and GAD.143 Id. Although he admits that petitioner was not tested for anti-GAD
antibodies recently, he says the results of the test provide objective evidence for her early

140
    Petitioner filed the complete record of June 15, 2016 at MedStar Georgetown, including the ED record, as Ex.
180. Dr. Steinman, in his sixth supplemental expert report, is referring only to the neurological portion of that
record which is Ex. 183.
141
    Neuromyotonia is “myotonia caused by electrical activity of a peripheral nerve, characterized by stiffness,
delayed relaxation, fasciculations, and myokymia.” Dorland’s at 1267. Myotonia is “dystonia involving increased
muscular irritability and contractility with decreased power of relaxation.” Id. at 1226. Myokymia is “a benign
condition marked by brief spontaneous tetanic contractions of motor units or groups of muscle fibers, usually
adjacent groups of fibers contracting alternately.” Id. at 1223.
142
    The undersigned identifies and discusses these three references in the section entitled “Medical Literature and
Other Filings.”
143
    Dr. Steinman discovered at the hearing that he had mistakenly analyzed the components of the trivalent flu
vaccine of the 2010-2011 flu season, and not the components of the trivalent flu vaccine petitioner received in 2009.
Tr. at 530-35.

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symptom onset. Id. at 10. He thinks the results of the test prove petitioner does not have
conversion disorder. Id. Dr. Steinman concludes that based on this recent information, he adds a
further assertion, i.e., that petitioner’s flu vaccination likely triggered autoimmunity to GAD
(glutamic acid decarboxylase). Id. at 12.
         Dr. Steinman engages in a paean to Dr. Sheean, reciting his credentials: In 2005, 2006,
Dr. Sheean won the Senior Faculty Teaching Award at the University of California, San
Diego.144 Id. Dr. Sheean joined the faculty of the University of California San Diego in
February 1998 and serves as Director of the Neuromuscular Division. The website continues
and states Dr. Sheean does both teaching and clinical research. He has used botox to treat
spasticity and movement disorders and maintains a demanding schedule of clinical activities,
including several weekly clinics, consisting of five EMG clinic sessions, one neuromuscular
clinic, one ALS clinic, one botulinum toxin injection clinic, and one botulinum toxin review and
assessment clinic. Id. at 5-6. Dr. Sheean treats patients with a variety of neuromuscular
conditions, including myasthenia gravis and peripheral neuropathy. Id. at 6. In July 2003, Dr.
Sheean was named Director of the Neurology Outpatient Clinic at Perlman Ambulatory Care
Center in La Jolla. In July 2004, Dr. Sheean helped establish the ALS Center at the UCSD
Medical Center in Hillcrest and served as co-Director for the first two years of operations. As
Director of the Neuromuscular Fellowship Program, Dr. Sheean is responsible for the selection
and training of fellows. All his clinics incorporate teaching for EMG Fellows and neurology
residents. He trains neurology residents in EMG and nerve conduction during their four-month
rotation through the service in their first year. One of the busiest clinics is devoted to using
botulinum toxin injections to treat focal dystonia, minifacial spasm, spasticity, and migraine. Dr.
Sheean provides tutorials and case presentations in the Clinical Core Clerkship course. He gives
an annual lecture and demonstration on nerve conduction and EMG in the basic neurology
course. He received the Clinical Teaching Award for 1999-2000. Id. Neither Dr. Steinman nor
the UCSD website mentions that Dr. Sheean is not board certified in neurology. See supra,
n.101.
         On December 16, 2016, respondent filed Dr. Whitton’s third supplemental expert report
(Ex. ZZZ) and Dr. Lancaster’s second supplemental expert report (Ex. FFFF). Dr. Whitton
states that Dr. Steinman’s initial reports suggest that petitioner suffered from rhabdomyolysis,
GBS, and autonomic ganglionopathy due to responses to a short amino acid sequence of myelin
basic protein. Ex. ZZZ, at 1. Dr. Steinman proposed this link to myelin basic protein by relying

144
   A UCSD website depicting Dr. Sheean’s name and his publications, and describing his title as “Associate
Physician Diplomate, Medicine” at Health Sciences. UCSD Profiles: Geoffrey Sheean, UC SAN DIEGO,
https://profiles.ucsd.edu/geoffrey.sheean (last visited Mar. 19, 2019). This website lists Dr. Sheean’s “concepts”
derived automatically from his publications. These research areas include: muscle spasticity; botulinum toxins, type
A; neuromuscular agents; electromyography; torticollis; etc. for a total number of 119 concepts. Among these
research areas, myasthenia gravis is not listed. https://profiles.ucsd.edu/display/180912/Network/ResearchAreas
(last visited Mar. 19, 2019). Dr. Sheean is no longer listed on the UCSD faculty website that Dr. Steinman used for
his description of Dr. Sheean’s past accomplishments: https://neurosciences.ucsd.edu/faculty/Pages/geoffrey-
sheean.aspx (last visited Mar. 20, 2019). Clicking on that cited page brings up this statement instead: “The page
you’re looking for doesn’t exist.” School of Medicine, UC SAN DIEGO SCHOOL OF MEDICINE,
https://medschool.ucsd.edu/Pages/PageNotFoundError.aspx?requestUrl=https://medschool.ucsd.edu/faculty/Pages/g
eoffrey-sheean.aspx (last visited Mar. 20, 2019).

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on a homology between that protein and flu vaccine. However, at the hearing, Dr. Steinman
realized he had erred because petitioner received a different vaccine than the one Dr. Steinman
had analyzed. As a result, Dr. Steinman openly rejected the myelin basic link and relied instead
on other vaccine sequences that he said were more important than the myelin basic protein
sequences and which he claimed could cause disease by cross-reacting with two other central
nervous system proteins (myelin oligodendroglial glycoprotein and 2,3CNPase). In Dr.
Steinman’s latest expert report (Ex. 191), he invokes another protein as a target for immune
cross-reactivity, i.e., glutamic acid decarboxylase (GAD). Id.
        Dr. Whitton notes petitioner displayed signs of distress at hearing, necessitating the
phone call to paramedics. The medical records from MedStar Georgetown University Hospital
note petitioner’s inspiratory stridor resolved after a single dose of Mestinon. Dr. Whitton
discusses a possible placebo effect of Mestinon because hospital personnel noted that petitioner’s
inspiratory stridor was inconsistent with myasthenia gravis. Id.
        Dr. Whitton discusses Dr. Steinman’s invoking a protein as a target for immune cross-
reactivity called GAD and says Dr. Steinman seems to be proposing in Ex. 191, at 11, that
petitioner suffers from stiff person syndrome. Ex. ZZZ, at 2. Dr. Whitton comments that Dr.
Steinman put a lot of weight on Dr. Sheean’s opinion, stressing repeatedly that he did so in part
because Dr. Sheean was on the staff at Scripps, the same outstanding institution where Dr.
Whitton works. As Dr. Whitton said at the hearing, to the best of his knowledge, Dr. Sheean
does not have an appointment at or association with the Scripps Research Institute where Dr.
Whitton works. (Apparently, Dr. Sheean has moved on professionally. He apparently is no
longer on the faculty of UCSD. See supra, n.144.).
         Dr. Whitton explains that GAD has two isoforms in humans: GAD65 and GAD67. Ex.
ZZZ, at 2. Antibodies specific for both these isoforms are associated with type 1 diabetes and
stiff person syndrome. Dr. Whitton says that Dr. Steinman in Ex. 191, at 11, appears to believe
that petitioner has stiff person syndrome. Dr. Whitton notes that petitioner’s detectable level of
GAD antibodies in her blood may not be significant because her blood level was very low. He
states this low level would not support the diagnosis of stiff person syndrome because, in stiff
person syndrome, the anti-GAD antibody levels are usually high. Secondly, he notes that
although anti-GAD antibodies are associated with stiff person syndrome does not mean they are
always causal. Instead, anti-GAD antibodies may be the consequence of stiff person syndrome.
Additionally, Dr. Whitton points out that petitioner received multiple IVIG infusions, which can
lead to false blood test results. He further notes that 1-2 percent of the general population has
anti-GAD antibodies. IVIG is prepared from a pool of about 1,000 blood donations and the
constitution of the IVIG reflects the serological status of the donor population. Dr. Whitton
expects that any preparation of IVIG would contain immunoglobulins from 10-20 donors who
are positive for anti-GAD antibodies. Id.
         Dr. Whitton moves on to Dr. Steinman’s identification of two homologies between a
vaccine protein, A/Brisbane/10/2007 (H3N2)-like virus, and human GAD. Id. at 3. Dr. Steinman
states there are four identical residues out of one in one homology and five out of seven identical
residues out of a second homology. But, Dr. Whitton says this applies only to mice who receive

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pertussis toxin and a strong adjuvant, which differs dramatically from flu vaccination
administered to humans. Moreover, Dr. Whitton notes that flu vaccine has never been shown to
cause EAE in mice. Id. Dr. Whitton says that Dr. Steinman does not provide any evidence that
an immune response to either of the GAD67 “homologies” actually occurs or is in any way
harmful. Id. at 3-4.
         Dr. Whitton states that short homologies are predictable and are not “remarkable” (as Dr.
Steinman characterized them). Id. at 4. Dr. Whitton continues that flu virus HA protein is 329
amino acids in length, whereas human GAD67 protein is 594 amino acids in length. Dr. Whitton
says it is not remarkable that there would be four out of five homologies or five out of seven
homologies between them. Id. Dr. Whitton says that short homologies are not unusual. Id. at 5.
He notes that viruses contain multiple proteins while the human proteome is thought to contain
about 30,000 proteins. A scientist would not be surprised to find a very large number of short
matches between the proteins of viruses and people merely by chance. Id. at 5-6.
         To illustrate the fallacy of Dr. Steinman’s thinking, Dr. Whitton did an experiment using
the same vaccine sequence Dr. Steinman used and comparing it by a BLAST search against
human albumin, a protein playing a key function in the bloodstream. Id. at 6. Human albumin at
609 amino acids is very similar in length to GAD67. He then shows that the vaccine protein had
several homologies with albumin, but the data is limited and does not prove disease causation.
Id. at 6-7. Dr. Whitton concludes that the mere presence of such homologies does not mean they
have biological significance. Id. at 7.
        In Dr. Lancaster’s second supplemental expert report (Ex. FFFF), he states that stress
may have triggered petitioner’s stridor on June 16, 2016 during the hearing in this case. Ex.
FFFF, at 1. He notes petitioner did not show any signs of myasthenia gravis during this episode.
She was able to move air strongly, as Dr. Steinman later noted. Her ability to move air strongly
was apparent from the loud sounds she generated while breathing, which required considerable
respiratory muscle strength. Dr. Lancaster also notes that the MedStar Georgetown University
Hospital records state petitioner had mild to moderate bilateral ptosis which looking up (i.e., up-
gaze) could overcome and which did not fatigue. Dr. Lancaster states this signifies that
petitioner’s ptosis may not be due to myasthenia gravis. Id. She might instead have had eye
closure weakness. The Georgetown neurologist Dr. Brian Barry who performed a physical
examination on petitioner expressed doubts about whether petitioner’s symptoms were
physiological because, although she measured 4/5 strength, she dropped her arms one to two
seconds after holding them up. Id. Dr. Barry noted petitioner had possible evidence of effort
dependence, meaning it was questionable how hard petitioner was trying to generate full strength
and questionable whether she had actual weakness. Id. at 1-2.
       Dr. Lancaster also notes petitioner had negative inspiratory force, which means she was
not weak in breathing. Id. at 2. Dr. Barry noted this negative inspiratory force was inconsistent
with myasthenia gravis weakness. Id. Dr. Lancaster quotes the Georgetown Hospital notes on
Dr. Gee’s phone call with Dr. Barry, to the effect that petitioner had frequently been admitted to
the hospital in California with low negative inspiratory force, which is effort dependent, but no
neuromuscular cause was believed associated with these spells and her myasthenia was stable.

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Dr. Gee also told Dr. Barry petitioner had been previously assessed for non-organic dystonia
attributed to a flu vaccination. Dr. Lancaster stresses this is a very important observation,
suggesting Dr. Gee believed petitioner’s abnormal gait after flu vaccination was non-organic,
i.e., did not have a physiological basis. This is another way of saying it is psychogenic. Id.
        Dr. Lancaster notes that petitioner’s GAD65 antibodies on August 4, 2016 were mildly
elevated at 22.2 units. Id. at 3. The normal range is 0.0 to 5.0 units. However, in Dr.
Lancaster’s experience, a strong GAD65 response is generally measured as >250 units.
Petitioner had normal test results for CK, copper, anti-thyroglobulin, thyroglobulin, TTG
antibody, SSA antibody, SSB antibody, ceruloplasm, and MuSK antibody. All of petitioner’s
objective tests for myasthenia gravis were negative. Id. On physical examination, petitioner did
not have stiff person syndrome. Another GAD65 antibody test was weakly positive at 11 units.
Dr. Lancaster notes that the diagnosis of myasthenia gravis was not raised until well over a year
after petitioner’s flu vaccination. Myasthenia gravis would not explain her lurching gait (astasia-
abasia), foreign-accent syndrome, ability to run but not walk, ability to walk backward, but not
forward, trouble concentrating, seizure-like spells, etc. Dr. Lancaster says he agrees with Dr.
Whitton’s analysis of GAD65 antibodies. They are found in one to two percent of the general
population. Petitioner’s low-titer GAD65 antibodies could have come from her IVIG infusions.
Id. Dr. Lancaster notes that Dr. Steinman’s proposed homology between flu vaccine components
and GAD65 resembles chance events. Id. at 4. Dr. Lancaster writes that people with type 1
diabetes frequently have GAD65 antibodies.
        Dr. Lancaster writes stiff person syndrome is an acquired disease causing increased
muscle tone. Stiff person syndrome patients have very strong GAD65 antibody responses. They
do not have sudden attacks of abnormal movements that rapidly resolve as petitioner’s abnormal
movements rapidly resolved. Stiff person patients do not have foreign-accent syndrome, seizure-
like events, and the ability to walk backward, but not forward. Dr. Lancaster writes petitioner
did not have stiff person syndrome in the three months after her flu vaccination or at any time
thereafter. Id. He says petitioner’s rapid response to chelation therapy drops and other
unconventional treatments Dr. Buttar gave her is entirely inconsistent with stiff person
syndrome. Id. at 5. Dr. Lancaster writes that stiff person syndrome patients would not respond
to Mestinon.
       Dr. Lancaster says that a subset of patients with epilepsy have GAD65 antibodies, but it
is unknown how the antibodies relate to the seizures. Id. Dr. Lancaster notes petitioner did not
have cerebellar degeneration. Patients with cerebellar degeneration may have GAD65
antibodies. Patients with cerebellar degeneration have progressive nystagmus and ataxia of their
limbs and gait. They have severe difficulty moving. These symptoms are static or slowly
progressive. They do not suddenly come and go over minutes. A patient with cerebellar
degeneration would not have a wildly lurching gait one minute and then run a race normally
seconds later. If patients with cerebellar gait disorders attempted petitioner’s wildly lurching gait
shown in her videos, they would fall. He states the many hours of videos are the key to
diagnosing petitioner with conversion disorder. Id.

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        Patients with encephalitis and opsoclonus-myoclonus may have GAD65 antibodies, but it
is unknown if the antibodies cause any of these syndromes. In any event, the GAD65 antibodies
are high titer. Petitioner did not have any of the syndromes associated with GAD65. Id.
        Dr. Lancaster comments that ptosis can be faked (psychogenic pseudoptosis) just by
lowering one’s eyelids. Id. at 6. The Georgetown neurologist overcame petitioner’s ptosis by
having her look up. Dr. Lancaster states physiological ptosis would not be overcome with up-
gaze. He also attributed petitioner’s recovery when she took Mestinon to the placebo effect. He
said there is no logical link between flu vaccination seven years previously and petitioner’s
recent measurement of GAD65 antibodies. Dr. Lancaster regards the IVIG infusions as the
cause of these GAD65 antibodies. Id.
        Dr. Lancaster questions the metamorphosis of Dr. Steinman’s constantly shifting theories
and diagnoses. Id. at 6. Dr. Lancaster states he is unsure of what Dr. Steinman’s current theory
of the case is on either an immunologic or clinical level. Dr. Steinman now seems to believe flu
vaccine caused GAD65 antibodies and therefore her symptoms. Dr. Lancaster states there is no
logical link between a vaccination administered seven years earlier and her recent measurement
of GAD65 antibodies. Also, this is a completely different theory than Dr. Steinman’s original
theories on autoimmunity to myelin basic protein. He asks if Dr. Steinman believes both
theories are true. Dr. Lancaster asks which specific type of autoantibody is supposed to have
caused petitioner’s foreign-accent syndrome, her ability to walk backward, but not forward, and
her ability to run but not walk. Dr. Lancaster says there is no reliable medical evidence that flu
vaccine can cause autoimmunity to either myelin basic protein or GAD65. Furthermore, there is
no evidence that petitioner had autoimmunity to myelin proteins at all, let alone that this would
have clinical significance. Now years after vaccination, she has a very low-titer GAD65
response, best explained by the IVIG infusions and unlikely to have any diagnostic significance.
Id.
        Dr. Lancaster notes that Dr. Steinman states he stands by his original opinions in this
case, but his initial diagnosis was that petitioner had a form of autonomic neuropathy. Id. at 6-7.
Dr. Lancaster states the autonomic nervous system controls unconscious or subconscious
neurological functions, including the regulation of heart rate, the regulation of blood pressure,
the constriction of pupils in response to light, sweating, etc. Id. at 7. The autonomic nervous
system does not regulate gait or accent; neither does it cause seizure-like events. Moreover,
autoimmune autonomic disorders such as autoimmune autonomic neuropathy have well-defined
clinical features: orthostasis, fixed or unresponsive pupils, anhidrosis, gastrointestinal
immobility, etc. Id. Dr. Lancaster recalls Dr. Steinman invoking the diagnosis of dystonia.
Dystonia involves the pathways for controlling voluntary motor functions in the brain. Patients
with dystonia have abnormal fixed postures or abnormal muscle contraction with movements.
Dystonia does not cause foreign-accent syndrome or petitioner’s wildly lurching gait (astasia-
abasia). Dystonia comes from the brain and not the autonomic nervous system. Many forms of
dystonia are considered of genetic origin and only a few cases are thought to be autoimmune,
such as dystonia of anti-NMDAR encephalitis. Thus, Dr. Lancaster identifies that Dr. Steinman

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introduced a second diagnosis with a completely different localization and pathophysiology with
the diagnosis of dystonia. Id.
        Dr. Lancaster notes that Dr. Steinman adds a third diagnosis to autonomic neuropathy
and dystonia: myasthenia gravis which was only suggested one year after vaccination. Id.
Myasthenia involves autoantibodies to the neuromuscular junction on the post-synaptic side, i.e.,
on the muscle side of the nerve-muscle communication. Dr. Lancaster stresses there is still no
objective evidence that petitioner has myasthenia gravis. She was tested for acetylcholine
receptor antibodies, MuSK antibodies, and with neurophysiology. The negative test results
strongly suggest the diagnosis of myasthenia gravis is incorrect. Moreover, petitioner’s
symptoms after vaccination are inconsistent with a diagnosis of myasthenia gravis. He states a
patient with active myasthenic weakness cannot run a 5K race, as petitioner did. Id.
        Dr. Lancaster notes that Dr. Steinman adds a fourth diagnosis, i.e., a GAD65-associated
syndrome. Dr. Lancaster wants to know which syndrome Dr. Steinman proposes: stiff person
syndrome, cerebellar ataxia. Dr. Lancaster states petitioner does not have either. Even if she had
those syndromes now, they would not explain her symptoms after vaccination since neither of
these conditions causes someone to run but not walk, to walk backward but not forward, to speak
with a foreign accent, or to have seizure-like events. Id. Neither syndrome would have the
dramatic responses to placebo seen in the videos when Dr. Buttar rubbed chelation drops on
petitioner’s forearms. Id.
        Dr. Lancaster states it would be entirely unprecedented for one patient to have so many
presumably autoimmune disorders affecting so many distinct areas of her nervous system. Id. at
8. He says it would be even more remarkable that her condition is able to remit completely,
sometimes in seconds, and leave no convincing objective evidence of its existence. By contrast,
conversion disorder is quite common and easily accounts for petitioner’s prominent symptoms
after vaccination and those evolving over time. Id.
        On May 16, 2017, petitioner filed Dr. Steinman’s seventh supplemental expert report.
Ex. 198. He thinks petitioner’s collapse and stridor in the courtroom on the second day of the
hearing was proof of her myasthenia gravis, a consequence of petitioner’s being overdue for
IVIG, and the stress of travel and of testifying in the case. Id. at 1-2. Dr. Steinman believes that
petitioner’s most recent May 2017 anti-GAD antibody test result of 37 proves she is undergoing
an immunologic process rather than a passive transfer of anti-GAD antibodies through IVIG
transfusions. Id. at 3. Dr. Steinman thinks that petitioner’s anti-GAD antibodies explain the
diagnoses of her myasthenia gravis, stiff person syndrome, intestinal pseudo-obstruction, and
autonomic neuropathy. Id. Dr. Steinman says that even if petitioner’s anti-GAD antibodies were
a result not of her illnesses but of passive transfer from her IVIG treatment, she would not be
receiving IVIG treatment but for her vaccine reaction, and therefore the anti-GAD antibodies are
a sequela of her vaccine injuries. Id. at 4.
       Dr. Steinman disagrees with Dr. Whitton’s dismissal of the homology thesis between flu
vaccine and human GAD that Dr. Steinman previously put forth. Id. He disagrees with Dr.
Whitton’s statement that short homologies are predictable. Id. at 7. Dr. Steinman notes that

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petitioner “is a complex individual, as we all are.” Id. at 18. He says that there are aspects of
petitioner’s responses in the videos that perplex him. He says, “Not everything in medicine is
clear cut, easy to diagnose, black and white.” Id. He relies on petitioner’s neurologists “who
made concrete diagnoses and prescribed powerful medicines.” Id. He thinks petitioner’s
insurance company would not have paid for petitioner’s IVIG treatments if IVIG were just a
placebo. He thinks, “A placebo effect under such circumstances is too speculative” and
undermines petitioner’s neurologists while elevating the “speculative opinion” of respondent’s
experts. Id.
        Dr. Steinman doubts that petitioner was feigning ptosis. Id. He recognizes that Dr.
Lancaster relied on the videos in supporting his opinion that petitioner has conversion disorder,
but Dr. Steinman says this is illogical because her treating physicians Dr. Cintron and Dr. Atiga
did not opine that. Id. Dr. Steinman said Dr. Cintron knew about the bizarre aspects of the case
and discussed sensory tricks but still did not think petitioner’s illness was functional, i.e., non-
organic. Id. at 19.
        On May 17, 2017, petitioner filed her supplemental declaration. Ex. 205. She states that
Dr. Gee told her that some of the spasms and tremors she manifested in her videos can be
explained by a high GAD antibody. On May 17, 2017, the undersigned issued an Order for
petitioner to file a statement from Dr. Gee indicating whether he believes petitioner had a high
GAD in 2009 and, if she did, whether the high GAD antibody would cause some of the spasms
and tremors she had in 2009 as shown in her videos. Moreover, the undersigned wanted to know
if Dr. Gee thought petitioner had myasthenia gravis in 2009. Petitioner filed a status report
stating Dr. Gee did not give her a statement to file.
        On June 19, 2017, petitioner filed Dr. Steinman’s eighth supplemental expert report. Ex.
206. Dr. Steinman writes that petitioner was not tested for high GAD antibody in 2009, but he
thinks that her early-onset symptoms indicate that she very likely did have a high GAD antibody
in 2009. Ex. 206, at 1. He notes that he previously attributed petitioner’s early symptoms of
tremors and spasms to myasthenia gravis. He attributes her other symptoms to high GAD as
well. He writes that petitioner has been diagnosed (or a doctor considered whether to diagnose
her) with many illnesses connected to anti-GAD antibodies: (1) stiff person syndrome; (2)
intestinal pseudo-obstruction;145 and (3) autonomic neuropathy. Id. He continues that
petitioner’s early onset of symptoms indicates: (1) myasthenia gravis; (2) intestinal pseudo-
obstruction; and (3) autonomic neuropathy. Id. He opines that petitioner did have myasthenia
gravis in 2009. Id. at 2. He believes that petitioner’s 2009 flu vaccination likely triggered
autoimmunity to GAD in petitioner. Id.
        On July 18, 2017, the undersigned issued an Order asking Dr. Steinman to clarify his
opinion since it shifted from an initial diagnosis of autoimmune autonomic neuropathy to explain
petitioner’s earliest symptoms to her having myasthenia gravis as the explanation for all her

145
   Intestinal pseudo-obstruction is “a condition characterized by constipation, colicky pain, and vomiting, but
without evidence of organic obstruction; it is frequently a motor disorder.” Dorland’s at 1545.

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symptoms. The undersigned gave petitioner the option to reopen testimony, amend her petition,
or any other action. Petitioner chose to file an amended petition and post-hearing briefs.
         On October 30, 2017, petitioner filed Dr. Steinman’s ninth supplemental expert report.
Ex. 208. He states it is not his opinion that all of petitioner’s initial symptoms were related to
myasthenia gravis. Id. at 3. He states GAD antibody helps explain all of petitioner’s symptoms,
including those relating to dystonia, gastroparesis, myasthenia gravis, and intestinal pseudo-
obstruction. Id. He notes petitioner’s GAD antibody tests ranged from 22.2 (August 4, 2016,
Ex. 185, at 3), to 11 (August 14, 2016, Ex. 189, at 1), to 6 (January 13, 2017, Ex. 207, at 4), to 37
(May 2, 2017, Ex. 204, at 1). Id. He attaches a medical article in which respondent’s expert Dr.
Lancaster is a co-author (Ex. 209) as proof that therapeutic plasma exchange and
immunosuppressive therapy lower levels of anti-GAD antibodies and improve clinical symptoms
(without mentioning that the patient on whom the article focuses had a level of GAD
autoantibody of 115,900IU/ml and, even after five sessions of therapeutic plasma exchange, had
an anti-GAD antibody level of 3,970IU/ml). See Ex. 209, at 4. This level of anti-GAD antibody
is profoundly higher than petitioner’s range of 6 to 37. Dr. Steinman concludes that flu vaccine
likely triggered petitioner’s autoimmunity to GAD. Ex. 208, at 5.
        On October 30, 2017, respondent filed the fourth supplemental expert report of Dr.
Whitton (Ex. MMMM) and the third supplemental expert report of Dr. Lancaster (Ex. QQQQ).
Dr. Whitton notes that Dr. Steinman agrees that IVIG infusions can passively transmit anti-GAD
antibodies. Ex. MMMM, at 1. Both Dr. Whitton and Dr. Lancaster point out that petitioner’s
serum reflected anti-GAD antibodies at a low titer. Dr. Whitton finds Dr. Steinman’s
disagreeing because the lab test results indicate a “high” reference value to be disingenuous
because anything above normal is reported as “high.” In practice, Dr. Whitton points out, the
extent of the elevation above normal is often expressed as “low” or “high” titer. Thus, slightly
above normal, as were petitioner’s lab results, would be referred to as “low titer,” while a huge
increase would be referred to as “high titer.” Id. Petitioner’s anti-GAD antibody titers between
6 and 37 were in the relatively low range, i.e., above normal, but not extremely high. Id. Dr.
Whitton states the upper limit of normal is 5IU/ml for anti-GAD antibodies. Id. at 2. Thus, the
lowest above normal reading petitioner could have would be 6, which she had on January 13,
2017. Stiff person syndrome patients have anti-GAD antibody titer levels that are very high,
from 600IU/ml to 3,000IU/ml. Id.
        Dr. Whitton emphasizes the changing diagnoses Dr. Steinman provides in his expert
reports over time. Dr. Steinman’s initial reports reflect his belief that petitioner had three
illnesses: rhabdomyolysis, GBS, and autonomic ganglionopathy. Id. Dr. Steinman claims all
three were responses to a homology between a short amino acid sequence in flu vaccine and
myelin basic protein. At the hearing, Dr. Steinman discovered he erred and explicitly abandoned
the homology of myelin basic protein and flu vaccine because petitioner received a different
vaccine than the one he analyzed. Dr. Steinman then discarded the homology to myelin basic
protein and relied on other vaccine sequences that he said were more important than the myelin
basic protein homology and which Dr. Steinman asserted cross-reacted with myelin
oligodendroglial glycoprotein and 2,3CNPase. In Ex. 191, Dr. Steinman added stiff person

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syndrome to petitioner’s conditions and asserted this resulted from immune cross-reactivity
between a vaccine protein and GAD. In Ex. 198, Dr. Steinman asserts petitioner has myasthenia
gravis, which his first report never mentions, but does not explain how flu vaccine triggers
myasthenia gravis. Id.
        Dr. Whitton points out that Dr. Steinman, in Ex. 198, did two identical BLAST searches
to look for homologies and reported different outcomes. Id. at 4. Dr. Whitton says that
comparing any two proteins of a reasonable length, e.g., 400-500 amino acids, would produce
homology of 5/12. Id. at 6. Dr. Whitton disagrees with Dr. Steinman that homology proves
molecular mimicry has occurred. Dr. Whitton notes that when a scientist injects a protein in a
lab animal, the animal makes immune responses only to certain parts of the protein, not to each
and every run of amino acids in the protein. Id. When a scientist finds a homology, he cannot
assume that a foreign part of the homology triggers any immune response in the animal. Dr.
Whitton states that proteins fold into complex three-dimensional structures and the relevant part
of the host protein may be hidden inside when the protein is folded and, therefore, inaccessible to
antibodies. Moreover, the sequences of the amino acids are different, meaning if this part of the
protein were on the outside of the folded ball of protein, a scientist cannot assume that the
immune response, taking the form of antibodies or T-cells, will be able to recognize it as its host
sequence. Id. Dr. Whitton adds that even if this hypothetical cross-reactive immune response
existed, a scientist would not assume it causes disease. Id. Dr. Whitton concludes that Dr.
Steinman has not provided evidence that flu vaccine can cause any of the various diseases that
have surfaced in his reports. Id. at 7.
        Dr. Lancaster in his third supplemental expert report notes that the reported parts of
petitioner’s neurological examinations reflected in Ex. 207 were normal, weighing against a
diagnosis of stiff person syndrome and not supportive of a diagnosis of active myasthenia gravis.
Ex. QQQQ, at 1. Dr. Lancaster states that myasthenia gravis, autonomic failure, and dystonia
are completely different disorders that affect different parts of the nervous system and have
different causes. No one should conflate these diseases or refer to them interchangeably or
consider them part of the same disease process. He also says that none of these disorders would
account for petitioner’s most prominent symptoms during the weeks and months after her flu
vaccination. He also cautions we should consider petitioner’s rapid responses to Dr. Buttar’s
treatment of these prominent symptoms in assessing the validity of their diagnoses. Id.
        Dr. Lancaster states myasthenia gravis is an autoimmune disease of the muscular junction
where nerve cells communicate with voluntarily-controlled muscles. Id. In most cases of
myasthenia gravis, autoantibodies to the acetylcholine receptor cause the disease, with smaller
groups having other autoantibodies. Id. at 1-2. He says GAD65 antibodies do not cause
myasthenia gravis and are not used clinically as a diagnostic test for myasthenia gravis. Id. at 2.
Dr. Lancaster notes that GAD65 antibodies are relatively common in the general population,
leading to patients with GAD65 antibodies who also have myasthenia gravis by chance. He
comments that petitioner’s test results in general are unsupportive of a diagnosis of myasthenia
gravis. He advises weighing the negative AChrR and MuSK tests against a diagnosis of
myasthenia gravis. Id.

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        Dr. Lancaster states patients with myasthenia gravis have severe weakness with attacks
occurring over many hours to days and weeks. They do not and cannot maintain wild lurching
gaits. They do not and cannot run 5K races in the middle of an attack. They do not speak with a
foreign accent. He says myasthenia gravis does not cause confusion, mental symptoms, or
numbness. Anyone who watched petitioner’s videos saw these symptoms clearly. He notes
these videos are extremely valuable in showing the viewers what was actually wrong with
petitioner in the weeks following vaccination. Id.
        Dr. Lancaster states that all of petitioner’s tests seeking objective confirmation of her
diagnosis of having myasthenia gravis were negative. He believes it very unlikely that petitioner
ever had myasthenia gravis. In her first years after the 2009 flu vaccination, no neurologist
suspected she had or diagnosed her with myasthenia gravis. Dr. Lancaster says he disagrees
strongly with Dr. Steinman that myasthenia gravis caused petitioner’s tremors and spasms.
Myasthenia gravis tends to make patients weak and slow, not cause the wild lurching gait
manifest on the videos. Patients with myasthenia gravis may show a slight limb tremor due to
difficulty holding the limb up while undergoing a severe attack, but that is not at all like the
hyperkinetic movement petitioner had on the videos. A person in myasthenic crisis who tried
this would simply collapse from exhaustion. Dr. Lancaster states a person with myasthenia
gravis can have a weak, quiet speech pattern, but myasthenia gravis would not cause a person to
speak loudly and clearly with a British accent.
        Dr. Lancaster continues with an analysis of petitioner’s alleged diseases. He states that
abnormal brain pathways for controlling motor movements cause dystonia, which is abnormal
posture or muscle tone. Id. The autonomic nervous system does not cause dystonia. Dystonia is
therefore not a form of dysautonomia. Myasthenia gravis, which originates in the brain, is not
the cause of dystonia. The type of dystonic gait petitioner manifested where she could walk
backward but not forward is generally considered to be either genetically caused or idiopathic,
but not autoimmune. Dr. Lancaster thinks petitioner did not have dystonia but conversion
disorder. He says dystonia does not cause attacks of weakness, foreign accent syndrome, mental
confusion, numbness, or seizure-like events. Dystonia is not a good explanation for petitioner’s
symptoms. Id.
        Dr. Lancaster then focuses on autonomic failure, which involves damage to the
autonomic nervous system, which regulates blood pressure, heart rate, sweating, shivering,
salivation, reactivity of pupils to light, urination, and mobility of the gastrointestinal tract. Id. at
2-3. Generally, no one has voluntary control of these functions. Id. at 3. The autonomic
nervous system does not control voluntary movements such as walking, talking, thinking,
sensation of touch, and seizure-like events. He says an autonomic disorder could not cause the
complex abnormal movements petitioner showed in the videos. Patients with autonomic failure
affecting their blood pressure control cannot run a 5K race. No autonomic disorder comes and
goes over a period of seconds, as petitioner’s symptoms rapidly improved and worsened in the
videos. Dr. Lancaster considers a diagnosis of autonomic failure to explain petitioner’s primary
symptoms “terrible.” Id.

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        Dr. Lancaster moves on to an analysis of the diagnosis of petitioner with autoimmune
autonomic neuropathy. He describes this as an incredibly severe autonomic disorder with
widespread failure of the autonomic nervous system. A person’s pupils do not react to light, he
or she cannot maintain his or her blood pressure, the heart rate may become fixed and invariant,
his or her sweating is impaired, etc. Id. Dr. Lancaster says petitioner did not have autoimmune
autonomic neuropathy. He states a patient with autoimmune autonomic neuropathy would not
run, would not walk with a lurching gait, and would not speak in one-word answers since the
disease is confined to the autonomic parts of the peripheral nervous system. Id.
        Dr. Lancaster then focuses on GAD65 antibodies, noting they are associated with several
different disorders. He is unclear which of these disorders Dr. Steinman thinks petitioner had.
Dr. Lancaster thinks it highly unlikely that petitioner had any of them. None of these disorders
rapidly turns on and off over a period of seconds. Rather, they persist for many weeks to months
and years. A patient with stiff person syndrome could not lurch and bob wildly but would have a
slow, cautious, stiff gait. Someone with the incoordination of cerebellar ataxia who attempted
the gait petitioner manifested would fall and injure himself or herself. Cerebellar degeneration
causes a severe and persistent, often permanent, inability to control muscles. Patients with
cerebellar degeneration are at severe risk of falling even when walking as normally as possible,
and often need walkers even if they can walk. Id.
        Dr. Lancaster states that Dr. Steinman’s clinical diagnoses in his latest report are highly
unlikely to be correct. Even if they were correct, they would not explain petitioner’s course after
her flu vaccination. Dr. Lancaster says the only reasonable diagnosis that explains petitioner’s
clinical findings is conversion disorder. GAD65 antibodies do not provide a rational explanation
for her symptoms. One to two percent of the general population have GAD65 antibodies,
especially at low titers. They are found in IVIG, raising the possibility that their presence in
petitioner is an artifact of IVIG treatment. By low titers, Dr. Lancaster means up to 10-20 times
normal. Id. In his practice, Dr. Lancaster evaluates GAD65 responses in spinal fluid in his
patients. Id. at 3-4.
        Dr. Lancaster says it is important to note that expert neurologists at Johns Hopkins
evaluated petitioner when she was talking in one-word answers. Id. at 4. They did not diagnose
petitioner with myasthenia gravis and she did not have myasthenia gravis. That diagnosis arose
years after her vaccination. He reiterates that Dr. Steinman conflated two unrelated diseases,
autoimmune autonomic neuropathy (involving peripheral nerves that control heart rate, blood
pressure, sweating, pupillary constriction, and other autonomic functions) with dystonia
(involving abnormalities in the tone and movement of muscles that are under voluntary control in
the arms, legs, neck face, and voice) arising from abnormal motor control in the brain and not the
autonomic nervous system. Id.
        Dr. Lancaster says petitioner’s GAD65 antibody test results have titers that fit his
definition of a weakly positive GAD65 response. For example, a response of 6IU/ml with a
normal range of 0-5IU/ml is only minimally positive. Other titer results were still less than 10
times the upper limit of normal, which would be 50 (petitioner’s highest titer was 37IU/ml).
Since petitioner’s treatment included IVIG and GAD65 is commonly present in some of the

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general population, she could possibly have this weak GAD65 result from her various doses of
IVIG. In addition, Dr. Lancaster says we do not know when petitioner acquired these GAD65
antibodies since doctors first measured them years after her flu vaccination and onset of
symptoms. Id. He notes petitioner does not have any of the neurological symptoms associated
with GAD65 antibodies. Id. at 4-5.
         Dr. Lancaster mentions that Dr. Gee’s diagnosis of petitioner with stiff person syndrome
is incorrect and was made years after her flu vaccination. Id. at 5. Dr. Lancaster states he treats
stiff person syndrome in his clinic and he did not observe any signs of it in petitioner during the
hearing. Not only does petitioner not have the symptoms of stiff person syndrome, but also the
diagnosis would not explain her symptoms after her flu vaccination. A patient with stiff person
syndrome does not have a wild lurching gait and, if he or she attempted such a gait, he or she
would probably fall down. Stiff person syndrome does not cause unexplained weakness, foreign
accent syndrome, seizure-like events, periods of apparent paralysis, numbness, and tongue
paralysis. He notes stiff person syndrome would not come and go rapidly over seconds. Patients
with stiff person syndrome do not walk better backward than forward. Instead, they would have
more difficulty walking backward than walking forward. Dr. Lancaster concludes that none of
petitioner’s treating physicians, with good reason, in the years after the onset of her symptoms
diagnosed her with stiff person syndrome. Id.
        Dr. Lancaster also disagrees with Dr. Gee’s diagnosis of petitioner having POTS. The
diagnosis was made years after her vaccination, is mostly likely incorrect, and would not explain
petitioner’s symptoms in the month after flu vaccination. POTS was considered as a possible
diagnosis in 2010. POTS manifests in lightheadedness, palpitations or something similar when
standing, accompanied by an abnormal increase in pulse rate. POTS is a syndrome and not a
disease, meaning the symptoms may have many causes. The possible causes could be
deconditioning, dehydration, and prolonged bedrest. Dr. Lancaster says POTS is generally not
an autoimmune disease. Id.
       Dr. Lancaster notes that POTS is sometimes considered a disorder of the autonomic
nervous system as a form of dysautonomia. Dr. Lancaster believes that petitioner did not have
an autonomic disorder in the months after vaccination and he does not think she has POTS and
that POTS is an explanation for her symptoms. Id. POTS would not cause foreign accent
syndrome, wild lurching gait, the ability to run but not walk, abnormal postures, numbness, or
symptoms occurring when supine. Id. at 5-6.
         Dr. Lancaster thinks Mestinon at MedStar Georgetown University Hospital had a placebo
effect on petitioner which is a reasonable possibility explaining her rapid recovery. Id. at 6. The
videos with Dr. Buttar and petitioner show a very powerful placebo effect when Dr. Buttar
rubbed chelation drops on petitioner’s forearms. In response to Dr. Steinman’s skepticism that a
person could have GAD65 antibodies without also having neurological symptoms, Dr. Lancaster
states it is far more likely that an individual has incidental GAD65 antibodies than the person has
stiff person syndrome. Id. Dr. Lancaster states that in his practice, a high-titer GAD65 is several
orders of magnitude above normal. Since normal is 0-5IU/ml, a strong positive titer would be
>250IU/ml. Petitioner’s GAD65 titer was as low as 6IU/ml and could not have been any lower

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and be positive at all. Her strongest titer (37IU/ml) was less than 8 times normal, i.e., 40IU/ml.
Id. Dr. Lancaster notes that Dr. Steinman neither endorses the diagnosis of stiff person disease
in petitioner nor rejects it. How then can Dr. Steinman be providing evidence of petitioner
having this disease if he is not willing to endorse it?
        Dr. Lancaster states Dr. Steinman is skeptical that IVIG could have a placebo effect on
petitioner’s symptoms. Dr. Lancaster refutes that skepticism by noting IVIG has a well-
recognized placebo effect. Id.
        Dr. Lancaster disagrees with Dr. Steinman about the importance of the video evidence.
Id. The central issue in this case is what occurred in the weeks and months after petitioner
received flu vaccine. Id. at 7. Dr. Lancaster states the videos provide hours of objective
evidence of what her symptoms and signs were. Id. Dr. Lancaster notes that Dr. Steinman was
“extremely reticent” in stating which of petitioner’s symptoms seen in the videos were due to
which disease process. Dr. Lancaster says this is “the core of the case.” Id. Dr. Lancaster notes
that diagnoses proposed years later are too remote in time to illuminate what was happening
contemporaneously with petitioner’s vaccination in 2009. Id.
        Dr. Lancaster questions the plausibility for petitioner’s having all the illnesses with which
doctors diagnosed her later on. He questions where petitioner’s abnormal brain MRIs and
abnormal CSF from her purported autoimmune encephalopathy are. He queries what specific
type of autoimmune encephalopathy did petitioner purportedly have. He questions where the
objective laboratory and electrophysiologic findings supporting a diagnosis of myasthenia gravis
are. He queries what objective evidence exists for petitioner’s having dysautonomia. He
questions what type of autoimmune dystonia petitioner supposedly had. He notes that Dr.
Steinman has not identified which type of dystonic disorder petitioner purportedly had or how flu
vaccine could trigger it and why the immune system would be involved. Id.
         Dr. Lancaster says if petitioner had myelin autoimmunity, she would be expected to have
widespread and obvious lesions throughout her nervous system, not dystonia. Id. at 8. Dr.
Lancaster states the four diagnoses Dr. Steinman proposes, i.e., autoimmune dysautonomia,
seronegative myasthenia gravis, dystonia, and GAD65 (stiff person syndrome and/or cerebellar
ataxia), are four completely different diseases affecting completely different parts of the nervous
system. Id. Dr. Lancaster says none of the four diseases captures what happened to petitioner
after flu vaccination, including cognitive difficulties, foreign accent syndrome, odd burning
sensations, ability to walk backward or run but not walk forward, numbness, and seizure-like
events. Id.
                                       Medical Literature
        Petitioner filed as reference 1 to Dr. Steinman’s first expert report (Ex. 65) a case report
by Sophie C. Skellett & Rosepal Dhesi, Myositis, rhabdomyolysis and compartment syndrome
complicating influenza A in a child, BMJ CASE REP (Dec. 17, 2009), published online:
doi:10.1136/bcr.07.2009.2099, as Exhibit 67. An eight-year-old boy with influenza A virus (not
vaccine) came down with fever, lethargy, vomiting, and, on day four, myositis, rhabdomyolysis,
renal failure, and compartment syndrome, leading to death from cardiorespiratory arrest and

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multiorgan failure. The authors state the most common cause of viral myositis in children is
influenza A and B. Id. at 3. In the case of the little boy, influenza A caused myositis, the muscle
cells swelled, and he had compartment syndrome from elevated pressure in a closed fascial
space. The authors note there are few case reports of rhabdomyolysis, renal failure, and
compartment syndrome in adults. Id. at 4. They also note that viral myositis is uncommon in
adults. Id. The authors also note that there are no reports of rhabdomyolysis, renal failure, and
compartment syndrome associated with influenza infection in children who received flu vaccine.
Id. at 5.
         Petitioner filed as reference 2 to Dr. Steinman’s first expert report (Ex. 65) a case report
by Rodrigo B. Callado et al., Rhabdomyolysis Secondary to influenza A H1N1 Vaccine
Resulting in Acute Kidney Injury, 11 TRAVEL MED & INFECTIOUS DIS 130 (2013), published
online: https://doi.org/10.1016/j.tmaid.2012.11.004, as Exhibit 68. A 58-year-old man on statins
developed rhabdomyolysis one day after receiving influenza A H1N1 vaccine. He went to the ED
four days later and underwent hemodialysis to recover renal function. The authors note that one
of the many factors causing rhabdomyolysis is exertion. Muscle toxicity has also been described
as one of the major adverse effects of statins. The patient also had diabetes mellitus,
hypercholesterolemia, coronary artery disease, and recurrent atrial flutter. The authors state
that, although influenza B virus has been reported as the most common viral cause of myositis,
influenza type A is associated more with rhabdomyolysis. Id. at 1. The patient had progressive
symmetric quadriparesis, pain in the upper limbs and lower back, dark urine and dysuria. The
patient had acute kidney injury classified as failure stage.
        Petitioner filed as reference 6 to Dr. Steinman’s first expert report (Ex. 65) a review by
Haruki Koike et al., The Spectrum of Immune-Mediated Autonomic Neuropathies: Insights from
the Clinicopathological Features, 84 J NEUROL NEUROSURG PSYCHIATRY 98 (2013), as Exhibit
72. The authors state that upper respiratory tract infections and gastrointestinal tract infections,
which are likely due to viral infections, are the most common antecedent infections causing
autoimmune autonomic ganglionopathies. Id. at 99. Case reports also indicate as causes
preceding influenza A, infectious mononucleosis, mumps, epididymitis, aseptic meningitis,
encephalitis, vaccination, surgical procedures, and interferon therapy. Id.
       Petitioner filed as reference 16 to Dr. Steinman’s first expert report (Ex. 65) an article by
Yu-Zhong Wang et al., Expression of Toll-Like Receptors 2, 4, and 9 in Patients with Guillain-
Barré Syndrome, 19 NEUROIMMUNOMODULATION 60 (2012), as Exhibit 82. The authors state
that GBS is characterized by the progressive weakness of extremities, which mostly an
antecedent respiratory or gastrointestinal tract infection triggers. Ex. 82, at 98.
        Petitioner filed as reference 19 to Dr. Steinman’s first expert report (Ex. 65) an article by
Steven Vernino et al., Invited Article: Autonomic Ganglia. Target and Therapeutic Tool, 70
NEUR 1926 (2008), as Exhibit 85. The authors state that, in many cases, an antecedent viral
syndrome such as upper respiratory symptoms or gastroenteritis precedes autoimmune
autonomic ganglionopathy (“AAG”), but no specific infectious agent has been consistently
identified. Id. at 1927. The authors note that about 14% of postural tachycardia syndrome

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(“POTS”) cases have a subacute onset and may follow a viral prodrome, much as in the case of
AAG. Id. at 1929.
        Petitioner filed as reference 20 to Dr. Steinman’s first expert report (Ex. 65) an article by
Steven Vernino et al., Autoantibodies to Ganglionic Acetylcholine Receptors in Autoimmune
Autonomic Neuropathies, 343 NEJM 847 (2000), as Exhibit 86. The authors state that clinical
features of autoimmune autonomic neuropathies are: a subacute onset, prominent symptoms of
gastrointestinal dysmotility, and an abnormal pupillary response to light and to accommodation.
Ex. 86, at 851. Besides testing for gastrointestinal dysmotility, doctors would have to test for
cardiovascular and sudomotor autonomic functions to diagnose autonomic neuropathy. Id. at
852. The authors note that autoimmune autonomic neuropathy is often a monophasic illness. Id.
at 854. In September-December 2009, petitioner did not have gastrointestinal dysmotility or
cardiac dysfunction and no one tested her for sudomotor autonomic function
        Petitioner filed as reference 21 to Dr. Steinman’s first expert report (Ex. 65) an article by
Steven Vernino et al., Autonomic Ganglia, Acetylcholine Receptor Antibodies, and Autoimmune
Ganglionopathy, 146 AUTON NEUROSCI 3 (2009), as Exhibit 87. The authors state that patients
with autoimmune autonomic ganglionopathy (“AAG”) typically do not have weakness or other
clinical features of myasthenia gravis (“MG”). Id. at 6.
         Respondent filed as reference 2 to Dr. Donofrio’s expert report (Ex. B) an article by
Walker B. Plash et al., Diagnosing Postural Tachycardia Syndrome: Comparison of Tilt Testing
Compared with Standing Haemodynamics, 123 CLIN SCI 109 (2013), as Exhibit E. The authors
disagree with the standard tilt-table test for POTS which is an increase in heart rate of 30 beats
per minute within 10 minutes of assuming upright posture because active standing forces blood
to return to the heart and results in passive tilt-test (false positive) results in nearly 15 percent of
healthy subjects who experience vasovagal episodes. Ex. E, at 109. They note that a 10-minute
tilt and a 30-minute tilt are not nearly as accurate when using 30 beats per minute as a cut-off.
Id. at 112. The 10-minute tilt-test with a 30 beat per minute cut-off was highly sensitive but had
poor specificity because it identified 60 percent of the control subjects as having POTS. Id. at
113. By increasing the heart rate cut-off to 37 beats per minute, the authors found the test was
much more specific to those who had POTS while maintaining sensitivity. Id. The authors
found that increasing the heart rate cut-off to 47 beats per minute increased the specificity to 80
percent while maintaining similar sensitivity. They note that an increase in heart rate is not the
only criterion for diagnosing POTS. Patients must also have symptoms of presyncope or
orthostatic intolerance. Id.
        Petitioner filed as reference 3 to Dr. Steinman’s first supplemental expert report (Ex. 92)
an article by Blair P. Grubb et al., The Postural Orthostatic Tachycardia Syndrome: A
Neurocardiogenic Variant Identified During Head-Up Tilt Table Testing, 20 PACE 2205 (1997),
as Exhibit 97. In half of their POTS patients, a viral illness appeared to precede the onset of
symptoms. Id. at 2210.
        Petitioner filed as reference 1 to Dr. Steinman’s second supplemental expert report (Ex.
108), a Medscape article by Michael T. Andary, Guillain-Barre Syndrome Clinical Presentation,

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MEDSCAPE (Sept. 4, 2014), https://emedicine.medscape.com/article/315632-clinical-overview, as
Exhibit 111. The author states that variants of GBS may present as acute dysautonomia. Ex.
111, at 1. The mean time to clinical function nadir is 12 days with 98% of patients reaching a
nadir by four weeks. Then, they experience a plateau of persistent, unchanging symptoms,
which gradual symptom improvement follows. Recovery usually begins two to four weeks after
the progression of symptoms ends. Id. The author states dysautonomia is more frequent in
patients with severe weakness and respiratory failure. It is important to note that petitioner’s
severe weakness was a consequence of rhabdomyolysis, not GBS, and she never had respiratory
failure. The author of the Medscape article notes that up to two-thirds of GBS patients have an
antecedent illness, usually upper respiratory and gastrointestinal, one to three weeks prior to
onset of weakness. Id. at 2. The author states reflexes in GBS patients are absent or reduced
early in the disease course. Id. at 3. Petitioner had normal reflexes.
        Petitioner filed as reference 3 to Dr. Steinman’s second supplemental expert report (Ex.
108) an article by Udaya Seneviratne (a neurologist at General Hospital, Ratnapura, Sri Lanka),
Review. Guillain-Barré Syndrome, 76 POSTGRAD MED J 774 (2000), as Exhibit 110. Dr.
Seneviratne is the sole author. She says autonomic dysfunction occurs in about two-thirds of
GBS cases. Ex. 110, at 776. She also states that a variant of GBS includes pure dystonia.146 Id.
at 778. She states rarely autonomic neuropathy may be the presenting feature of GBS. Id. at
779. However, she also states that in order to diagnose GBS, progressive motor weakness and
areflexia are prime requirements and CSF analysis is the only laboratory criterion. Id. at 780.
Petitioner did not satisfy those prime requirements of GBS as she did not have motor weakness
and areflexia and her CSF protein on lumbar puncture was normal.

146
   Dr. Seneviratne relies on two articles for her statement that a variant of GBS includes pure dystonia. The first is
by Emilia-Romagna Study Group on Clinical and Epidemiological Problems in Neurology, Guillain-Barré
Syndrome Variants in Emilia-Romagna, Italy, 1992-3: Incidence, Clinical Features, and Prognosis, 65 J NEUROL
NEUROSURG PSYCHIATRY 218 (1998). The authors feature 11 patients. Id. at 220. None of these patients had pure
dystonia. Six of them had either facial diplegia or bifacial weakness among other symptoms. One had asymmetric
motor defect, nystagmus, and areflexia, among other symptoms. Another had upper limb motor defect with cervical
pain. Another had pure sensory defect, absent ankle reflexes, and elevated CSF protein. The remaining patient had
motor-sensory defect, abdominal hypesthesia, and sensory ataxia. Id. at 220-21. None of them had pure dystonia.
The Emilia-Romagna Study Group on Clinical and Epidemiological Problems in Neurology does state a variant of
GBS is pure pandysautonomia, citing to the same article Dr. Seneviratne cites as her second basis for writing pure
dystonia can be a GBS variant. That article is the Ropper article. It does not however describe pandysautonomia or
pure dystonia as a GBS variant. Allan H. Ropper, Unusual Clinical Variants and Signs in Guillain-Barré Syndrome,
43 ARCH NEUROL 1150 (1986). Dr. Ropper describes three patients with blurred or double vision, ptosis, marked
oropharyngeal, neck, and shoulder weakness, respiratory failure with areflexia in the arms of two of the patients.
Another had areflexia and elevated protein. The third had severe oropharyngeal weakness, ptosis, absent or low
reflexes and an elevated CSF protein. The doctors considered whether these patients had botulism. Id. at 1150-51.
Petitioner did not have any of these symptoms or signs. Dr. Ropper describes another three patients who had
areflexic paraparesis resembling a spinal cord lesion with elevated CSF protein. Petitioner did not have any of these
symptoms or signs. Id. at 1151. Dr. Ropper describes eight patients with severe ptosis and mild facial weakness
early in their illness, resembling myasthenia gravis. Five of them developed typical GBS symptoms and eight
developed the restricted pharyngeal-cervical-brachial form. Id. at 1151-52. Petitioner did not have any of these
symptoms or signs. Dr. Ropper describes two patients with acute severe midline back pain followed by a typical
generalized GBS, including bifacial paresis. Id. at 1152. Petitioner did not have any of these symptoms or signs.

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        Respondent filed as reference 1 to Dr. Lancaster’s expert report (Ex. H) a review by Rodi
Zutt et al., Rhabdomyolysis: Review of the Literature, 24 NEUROMUSCUL DISORD 651 (2014), as
Exhibit J. The authors define rhabdomyolysis as the rapid breakdown of skeletal muscle fibers,
which leads to leakage of potentially toxic cellular contents into systemic circulation. Id. at 651.
About 26,000 cases of rhabdomyolysis are reported annually in the United States. Id. at 652.
The authors state many symptoms of rhabdomyolysis are non-specific, including myalgia,
swelling, and weakness. Id. Patients may have fever, nausea, emesis, confusion, agitation,
delirium, and anuria. Id. Muscle weakness can occur in any part of the body, but most
frequently occurs in proximal leg muscles. Id. Among numerous causes of rhabdomyolysis that
the authors list are viral infections and extreme physical exertion. Id. at 254. If a patient
experiences a first episode of rhabdomyolysis but no family history of it, the authors state an
environmental factor is the most likely cause in 75 percent of cases. Id. at 255.
        Respondent filed as reference 2 to Dr. Lancaster’s expert report (Ex. H) a case report by
Sneh V. Shah & Krishna Reddy, Rhabdomyolysis with Acute Renal Failure Triggered by the
Seasonal Flu Vaccination in a Patient Taking Simvastatin, BMJ CASE REPORTS, published
online: https://doi:10.1136.bcr.11.2009.2485 (2010), as Exhibit K. Noting that their case was
extremely rare, the authors describe a man in his 70s taking a statin (simvastatin) who had
symptoms of rhabdomyolysis within 24 hours of receiving seasonal flu vaccine. Id. at 1. He
entered the hospital where he had hospital-acquired pneumonia and multiorgan failure. Id. The
authors note that the patient did not have a history of any symptoms suggestive of an infectious
illness before his vaccination and, therefore, the authors felt that viral infection was unlikely to
be the cause of his rhabdomyolysis. Id. at 2. Because acute viral infections can cause
rhabdomyolysis, the authors considered the patient’s flu vaccination as the trigger of his
rhabdomyolysis in the context of the risk factor of his taking a statin. Id.
        Respondent filed as reference 4 to Dr. Lancaster’s expert report (Ex. H) an article by
Sonia Berrih-Aknin et al., Diagnostic and Clinical Classification of Autoimmune Myasthenia
Gravis, 48-49 J AUTOIMMUN 143 (Feb – Mar 2014), published online:
https://doi.org/10.1016/j.jaut.2014.01.003, as Exhibit M. In intermediate cases of myasthenia
gravis, symptoms include marked fatigue, impaired swallowing, a hypernasal voice, and
diplopia. Id. at 143. Severe myasthenia gravis involves respiratory muscles and severe
swallowing disorders. Id. They note a myasthenia crisis could be life-threatening involving
shortness of breath, choking, and rapid motor deterioration. Id. at 146. They say the number of
myasthenia patients with unknown antibodies is less than 5 percent. Id. at 147.
        Respondent filed as reference 5 to Dr. Lancaster’s expert report (Ex. H) an article by
Eduardo E. Benarroch, The Clinical Approach to Autonomic Failure in Neurological Disorders,
10 NAT REV NEUROL 396 (2014) as Exhibit N. Benarroch states, “Many symptoms attributed to
‘dysautonomia’ in otherwise healthy young patients, such as gastroparesis or urinary retention,
are rarely associated with objective evidence of autonomic failure. Id. at 396. He also states that
onset of symptoms of autoimmune autonomic ganglionopathy may follow a viral infection,
minor surgical procedure, or vaccination. Id. at 401. He mentions adverse effects for drugs
prescribed for orthostatic hypotension: (1) midodrine - scalp tingling; (2) pyridostigmine -

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nausea, abdominal cramps, and diarrhea; (3) octreotide - nausea and abdominal cramps. Id. at
403. Petitioner was taking these drugs.
        Respondent filed as reference 4 to Dr. Whitton’s expert report (Ex. Z) a case report by
Michael D. Nauss et al., Viral Myositis Leading to Rhabdomyolysis: A Case Report and
Literature Review, 27 AM J EMERG MED 372.e5 (2009), as Exhibit EE. The authors state,
“Several viruses have been implicated in rhabdomyolysis: influenza A/B, parainfluenza,
coxsackie, Epstein-Barr, herpes simplex, adenovirus, and cytomegalovirus.” Id. at 372.e5. In
their case report, a 29-year-old man came to the ED, complaining of dark urine and muscle pain.
About 10 days before, he had developed fevers and a cough. Four days before going to the
hospital, he developed muscle swelling in his calves and arms associated with weakness. The
authors note that, in adults, the most common causes of rhabdomyolysis are exertion, crush
injury, seizures, alcohol, viruses, drug abuse, and use of statins. Id. They posit three possible
causes to explain viral-associated myositis: (1) direct viral invasion of myocytes; (2) viral
mediated myotoxic cytokines released by infection; these cytokines include tumor necrosis factor
that can cause skeletal muscle breakdown; and (3) autoimmune myositis resulting from the viral
infection. Id. at 372.e6. The time from viral illness to the onset of myositis varies from
coincidental to a three-week delay. Id.
        Respondent filed as reference 6 to Dr. Whitton’s expert report (Ex. Z) a case report by
Nikhil Sharma et al., Exercise-Induced Rhabdomyolysis: Even the Fit May Suffer, 53 INT J CLIN
PRACT 476 (1999), as Exhibit GG. The authors report the case of a female 29-year-old family
doctor who had been using a gym two or three times a week for about four years, exercising for
60 minutes including resistance work followed by a 15-minute swim. Id. at 476. Three days
before she came to the hospital, she attempted a new exercise called body biking which entailed
standing on the pedals of a stationary bike for 40 minutes, moving up and down against
resistance, followed by a swim of 10 minutes. The next day, her thighs were excessively painful
and slightly swollen. The pain worsened considerably 24 hours later and her urine turned dark
brown. She was on oral contraceptives but took no other medication. The hospital diagnosed
her with rhabdomyolysis. The authors state an increase in intracellular calcium is an important
factor in the muscle injury. Damage to muscle cell membranes leads to an influx of sodium
which disrupts the relationship between intracellular sodium and calcium, leading to a rise in
intracellular calcium. Id. The authors say the development of rhabdomyolysis following
exercise depends on the extent of the muscular activity, the condition of the athlete, and the type
of muscular contraction involved. Id. at 477. They conclude, “Even a young, fit woman without
apparent risk factors and who exercises regularly can develop acute rhabdomyolysis with only a
modest change to her exercise routine.” Id.
        Respondent filed as reference 7 to Dr. Whitton’s expert report (Ex. Z) an article by Pieter
A. van Doorn et al., Clinical Features, Pathogenesis, and Treatment of Guillain-Barré Syndrome,
7 LANCET NEUROL 939 (2008), as Exhibit HH. The authors describe the first symptoms as pain,
numbness, paresthesia, or weakness in the limbs. Ex. HH, at 939. The main features of GBS are
rapidly progressive bilateral and relatively symmetric weakness of the limbs with or without
involvement of respiratory muscles or cranial-nerve-innervated muscles. Id. CSF examination

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by lumbar puncture typically shows increased protein. Patients have decreased or absent deep
tendon reflexes. Id. Citing a Japanese study, the authors state the most frequent antecedent
symptoms in GBS were fever, cough, sore throat, nasal discharge, and diarrhea. Id. at 940. They
state, “an argument for the post-infectious nature of GBS is the typical monophasic clinical
course of the disease.” Id.
        Petitioner filed as reference 7 to Dr. Steinman’s third supplemental expert report (Ex.
118) an article by Arthur K. Asbury et al., The Inflammatory Lesions in Idiopathic Polyneuritis.
Its Role in Pathogenesis, 48 MEDICINE 173 (1969), as Exhibit 126. The authors studied 19 cases
of people with polyneuritis who died. They state the clinical picture encountered most
frequently was weakness progressing to paralysis in legs, arms, and respiratory musculature over
three to seven days. Ex. 126, at 201. Motor weakness overshadowed sensory disturbances in all
cases, but most patients complained of paresthesia and tingling. Id. As the illness evolved, CSF
protein levels rose. Id. at 202. The pathologic hallmark of idiopathic polyneuritis is perivenular
mononuclear inflammatory infiltrate, which occurred in all 19 cases. Id. They found lesions
throughout the peripheral nervous system. Id. at 203. Petitioner did not have any lesions in her
peripheral nervous system as all her EMGs and nerve conduction studies were normal.
        Petitioner filed as reference 10 to Dr. Steinman’s third supplemental expert report (Ex.
118) an article by Stanley Fahn, Clinical Variants of Idiopathic Dystonia, J NEUR NEUROSURG &
PSYCHIATRY Supp 96 (1989), as Exhibit 129. Fahn states, “The presence of clinical clues, such
as fake weakness, somatisations [sic], and deliberate slowness of movement, serve to lead one to
the diagnosis of psychogenic dystonia.” Id. at 97.
        Petitioner filed as reference 11 to Dr. Steinman’s third supplemental expert report (Ex.
118) an article by Alexander G. Munts & Peter J. Koehler, Occasional Paper. How psychogenic
is dystonia? Views from Past to Present, 133 BRAIN 1552 (2010), as Exhibit 130. The authors
list seven reasons why focal dystonias have been regarded as psychogenic: (1) the bizarre nature
of the dyskinesias; (2) their appearance frequently only during certain actions while other motor
acts using the same muscles are done normally; (3) certain inexplicable trick actions relieving
the dyskinesias; (4) the manifestation of dyskinesias being exquisitely sensitive to social and
mental stress; (5) the failure to find any anatomic, physiologic, or biochemical abnormality in
any of the dyskinesias; (6) the impression that the patient shows overt psychiatric disturbance;
and (7) a psychopathologic interpretation of the significance of dyskinesias such as eye closure
or neck turning. Ex. 130, at 9.
       Petitioner filed as reference 13 to Dr. Steinman’s third supplemental expert report (Ex.
118) an article by Guillermo A. Suarez et al., Idiopathic Autonomic neuropathy: Clinical,
Neurophysiologic, and Follow-up studies on 27 Patients, 44 NEUROLOGY 1675 (1994), as Exhibit
132. The authors included from their study those who had neurotoxic drug exposure and those
with acquired polyneuropathies, i.e., chronic inflammatory demyelinating polyneuropathy
(“CIDP”), acute inflammatory demyelinating polyneuropathy (“AIDP”), and neuropathies
associated with monoclonal gammopathy of undetermined significance. Ex. 132, at 1. Dr.
Steinman uses the Suarez article as proof for his thesis that someone with GBS or AIDP can
have a primary autonomic nervous system disease, i.e., that patients with idiopathic autonomic

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neuropathy are on a spectrum with patients who have AIDP, yet the Suarez authors explicitly
eliminated patients with AIDP from their study. The authors also excluded patients with POTS.
Id. Petitioner allegedly has POTS, which means the authors would have excluded her from this
study. The authors also excluded patients on anticholinergic and antidepressant medications, id.,
which would have been a further reason to exclude petitioner from their study.
         The authors thoroughly tested the patients with various tests that would prove autonomic
failure, including the thermoregulatory sweat test, the quantitative sudomotor axon reflex test
(QSART), abnormal EMG, and plasma norepinephrine testing in both supine and upright
positions. Id. at 2. Petitioner either passed these tests or never took them. The authors again
would not have included her in patients with idiopathic autonomic neuropathy.
        Twenty-seven patients, including 18 females and nine males, met the authors’ criteria for
idiopathic autonomic neuropathy. Id. at 3. Their ages ranged from 7 to 75 years, with a mean of
45 years. The onset of symptoms was acute (less than two weeks) in 10 patients, subacute (up to
eight weeks) in 12 patients, and gradual in five. Id. In 16 patients, a presumed viral infection
preceded the onset of symptoms. An antecedent or concurrent flulike syndrome or upper
respiratory infection occurred in 11 patients. Id.
       The most common symptoms, occurring in 21 out of 27 patients, were orthostatic
symptoms, e.g., persistent and severe lightheadedness, dizziness, or near syncope upon standing.
Nineteen patients reported gastrointestinal symptoms, e.g., nausea, vomiting, diarrhea,
constipation, and postprandial bloating. Seventeen patients had symptoms of thermoregulatory
impairment and heat intolerance, e.g., becoming hot, dizzy, and flushed during exercise or
elevated temperatures but would not sweat. Ten patients had visual and ocular symptoms, e.g.,
blurred vision, photophobia, and dry eyes. Nine patients had urinary symptoms, e.g., difficulty
voiding to urinary retention. Seven patients (26%) had neuropathic symptoms to tingling and
numbness in their feet and hands. Id.
        Except for variable postural hypotension, 14 patients had normal neurologic exams. Six
patients had mild limb weakness. Nine patients had impaired deep tendon reflexes. Seven
patients had distal sensory deficits. The CSF protein level in 10 of 27 patients was evaluated
with a mean slight elevation of 46.9mg/dL with a range from 22 to 67mg/dL. No other
serologic or immunologic abnormalities were recorded in lab studies. Id.
        The authors surmised that the majority of these 27 patients had a monophasic course with
a progressive phase followed by a plateau and remission, or a prolonged stable deficit without
remission or recurrence. Id. at 6. There was a trend to recovery of function in two and one-half
years, but not complete recovery. Severe autonomic failure in 17 patients at initial presentation
was the most common degree of abnormality (63%). Id.
       The authors suspected the lesion is in the peripheral (preganglionic or postganglionic147)
nervous system for the following reasons: (1) none of the 27 patients had clinical evidence of

147
   Preganglionic is “situated anterior or proximal to a ganglion; said especially of autonomic nerve fibers so
located.” Dorland’s at 1509. Postganglionic is “situated posterior or distal to a ganglion; said especially of
autonomic nerve fibers so located.” Id. at1502. A ganglion is “anatomic terminology for a group of nerve cell

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CNS involvement (brain/spinal cord); (2) 24 patients had evidence of postganglionic sudomotor
denervation on the summated QSART (distal legs and proximal foot); (3) combining the results
of the TST and the summated QSART, the authors note 20 patients had evidence of a peripheral
postganglionic lesion; (4) three patients had electrophysiologic evidence of peripheral somatic
nerve involvement on EMG; (5) four patients had histopathologic evidence of a neuropathic
process on nerve biopsy; and (6) recovery of function, although incomplete, occurred in the
majority of patients. Id. at 7. The authors state this recovery argued against a central lesion
because central axons do not regenerate whereas peripheral axons can regenerate. Id.
        The authors conclude that significant overlap of symptoms of idiopathic autonomic
neuropathy with those who have AIDP or GBS exists since persons with AIDP or GBS can have
autonomic involvement. Id. That is a different statement than Dr. Steinman makes, i.e., that
someone with an autonomic nervous system disease has AIDP or GBS because someone with
AIDP or GBS can have autonomic nervous system symptoms as well. The spectrum the authors
create is not AIDP/GBS but of idiopathic autonomic neuropathy whose spectrum runs from
idiopathic autonomic neuropathy to AIDP/GBS. They state, “Idiopathic autonomic neuropathy
is at one end of the spectrum and AIDP is at the other, as the brunt of the disorder affects the
somatic nervous system in AIDP.” Id.
         Of note, Dr. Steinman quotes in his expert report a sentence from the abstract of the
Suarez article which is not verbatim in the article itself: “Pathologic features include the presence
of a small inflammatory mononuclear cell infiltrate148 in the epineurium.149” Cf. Ex. 118, at 21,
with Ex. 132, at 1 (abstract). By including that sentence in his expert report, Dr. Steinman
conveys the impression that this pathologic finding was common in the Suarez article’s study of
27 patients with idiopathic autonomic neuropathy. This is not true. The authors found this
pathologic presence in only one patient. Ex. 132, at 5. In a section entitled “Pathologic studies,”
the authors describe different pathologic results from different patients among the 27 who were
the subject of the article. The authors state without comment, “A small mononuclear cell
infiltrate surrounding an epineurial vessel, without changes typical of necrotizing vasculitis, was
found in one patient.” Id.
       Petitioner filed as reference 14 to Dr. Steinman’s third supplemental expert report (Ex.
118) an article by Joan Sneddon, Myasthenia Gravis—The Difficult Diagnosis, 136 BRIT J
PSYCHIAT 92 (1980), as Exhibit 133. The author describes four cases of myasthenia gravis
which had delayed diagnosis. She goes on to write:
                  Pseudo-myasthenia gravis must also be mentioned [citation
                  omitted]. Such patients, mainly women, show this syndrome as

bodies located outside the central nervous system.” Id. at 757. “Anterior” means “in front of.” Id. at 98.
“Posterior” means “situated in back of.” Id. at 1502.
148
    Infiltration is “the pathological accumulation in tissue or cells of substances not normal to it or in amounts in
excess of the normal.” Dorland’s at 936. Cellular infiltration is “the migration and accumulation of cells within the
tissues.” Id. at 936. Mononuclear means “a cell having a single nucleus, especially a monocyte of the blood or
tissues.” Id. at 1177.
149
    The epineurium is “the outermost layers of connective tissue of a peripheral nerve, surrounding the entire nerve
and containing its supplying blood vessels and lymphatics.” Dorland’s at 634.

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                  part of a long history of conversion hysteria. They have some of
                  the symptoms of myasthenia and are able to tolerate large doses of
                  cholinesterase inhibitors without getting side-effects but if the
                  drugs are withdrawn do not go into myasthenic crisis.
Ex. 133, at 93.
        Petitioner filed as reference 17 to Dr. Steinman’s third supplemental expert report (Ex.
118) a review article by Glenis K. Scadding & C.W.H. Havard, Pathogenesis and Treatment of
Myasthenia Gravis, 283 BMJ 1008 (1981), as Exhibit 136. The authors state that typically
someone with myasthenia gravis has worse muscle weakness after effort which is improved by
rest. Ex. 136, at 1008. Interestingly, petitioner felt better when she ran than when she was at
rest. In 2011, she was exercising 20 hours a week, which is nearly three hours a day.
       The authors note that generalized myasthenia has three clinical patterns: (1) association
with thymoma;150 (2) association with thymitis151 under the age of 40; and (3) association with
thymitis over the age of 40. Id. Petitioner does not fall into any of these three clinical patterns.
She did not have thymoma or thymitis.
        Petitioner filed as reference 19 to Dr. Steinman’s third supplemental expert report (Ex.
118) a case report by Jacqueline I. Bakker et al., Foreign Accent Syndrome in a Patient with
Multiple Sclerosis, 31 CAN J NEUROL SCI 271 (2004), as Exhibit 138. The authors report a 52-
year-old woman with relapsing remitting MS who had a Dutch accent with other neurologic
symptoms that resolved simultaneously. Ex. 138, at 271. Her brain MRI showed deep white
matter lesions in the corpus callosum, left parietal lobe, and left frontal lobe, which the authors
said were consistent with previous reports of foreign accent syndrome. Id. at 271-72. The
patient recovered from foreign accent syndrome after she received treatment with high dose
methylprednisolone. Id. at 272. The authors review reported cases of foreign accent syndrome,
noting that most of the reported cases involve lesions in the dominant inferior dorsolateral
premotor cortical-striatal-pallidal-thalamic circuit which mediates motor speech planning. Id.
The authors opine the patient’s MS caused her episodes of foreign accent. In the instant action,
petitioner’s brain MRIs were normal and she does not have MS.
        Respondent filed as reference 1 to Dr. Lancaster’s second supplemental expert report (Ex.
RR) a review article by Donald B. Sanders & Jeffrey T. Guptill, Myasthenia Gravis and
Lambert-Eaton Myasthenic Syndrome, 20 CONTINUUM 1413 (2014), as Exhibit WW. The
authors state, “Diseases that affect the neuromuscular junction are characterized by weakness
that predominantly affects certain muscle groups and fluctuates over time, worsening with use
and improving after rest.” Ex. WW, at 1413. In contrast, petitioner stated to her doctors on
numerous occasions that she felt better exercising and worse at rest, which is the exact opposite
of what a patient with myasthenia gravis should be experiencing.

150
    Thymoma is “a tumor derived from the epithelial or lymphoid elements of the thymus.” Dorland’s at 1925. The
thymus is “a bilaterally symmetric lymphoid organ consisting of two pyramidal lobes situated in the anterior
superior mediastinum. … The thymus is the site of production of T lymphocytes.” Id.
151
    Thymitis is “inflammation of the thymus.” Dorland’s at 1924.

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         Respondent filed as reference 5 to Dr. Lancaster’s second supplemental expert report (Ex.
RR) an article by Mark Hallett et al., Psychogenic Movement Disorders, 18S1 PARKINSONISM
REL DISORD S155 (2012), as Exhibit ZZ. The authors list clues to diagnose a psychogenic
movement disorder: (1) movements may be inconsistent over time; (2) tremors may come and go
and vary in frequency; (3) movements are sometimes difficult to classify and may be a mixture
of disorders, such as myoclonus, chorea, and dystonia; (4) movements might be so unusual that a
doctor may view them as bizarre; (5) distraction may cause a movement to disappear; and (6)
suggestion might precipitate a movement to appear. Ex. ZZ, at S156. Someone with a
psychogenic movement disorder might have extreme slowness, sometimes appearing markedly
fatigued. On physical examination, the patient might have give-way weakness or psychogenic
patterns of sensory loss. Id. Psychogenic tremor is often highly variable in frequency, direction,
and amplitude. The tremor can vary or cease with distraction. The authors write psychogenic
gait is characterized by unusual patterns of stance and gait which are often inconsistent and
dramatic with lurching but with only rare falls and no injury. Sudden knee buckling without
falling is a common pattern. Id. Petitioner manifested all these characteristics of psychogenic
movement.
        Respondent filed as reference 1 to Dr. Whitton’s third supplemental expert report (Ex.
SS) an article by Bianca van den Berg et al., Guillain-Barré Syndrome: Pathogenesis, Diagnosis,
Treatment and Prognosis, 10 NAT REV NEUROL 469 (2014), as Exhibit TT. The authors state,
“GBS typically occurs after an infectious disease in which the immune response generates
antibodies that cross-react with gangliosides at nerve membranes.” Ex. TT, at 469. They note
that GBS is characterized by rapidly progressive, symmetrical limb weakness with hyporeflexia
or areflexia. Id. at 470. They also state progressive weakness reaches its maximum within four
weeks and often within two weeks. Id. The authors state “vaccinations might even reduce the
risk of acquiring GBS, as this condition can be caused by infections such as influenza.” Id. at
472. They state the risk of developing GBS after flu infection is estimated to be four to seven
times higher than after flu vaccination. Id.
        Petitioner filed as reference 3 to Dr. Steinman’s fourth supplemental report (Ex. 141) an
article by Daniel B. Drachman, The Biology of Myasthenia Gravis, 4 ANN REV NEUROSCI 195
(1981), as Exhibit 144. The author states the cardinal features of myasthenia gravis consist of
weakness and fatigue of skeletal muscles, involving impairment only of the motor system. Ex.
144, at 1-2. Sensation, reflexes, coordination, and other neural functions remain normal. Id. at
2. Often ptosis and diplopia are involved. “In severe cases, the patient’s life may be endangered
by weakness of the muscles of respiration and swallowing.” Id. Muscle strength rapidly fatigues
on repeated or sustained contraction and may improve after resting.
        Petitioner filed as reference 5 to Dr. Steinman’s fourth supplemental report (Ex. 141) an
article by Irving Nachamkin et al., Anti-Ganglioside Antibody Induction by Swine
(A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine-Associated Guillain-
Barré Syndrome, 198 J INFECT DIS 226 (2008), as Exhibit 146 (respondent also filed this as Ex.
LLL before the hearing). The authors suspected that swine flu vaccine contained contamination
from Campylobacter jejuni (“C. jejuni”) antigens that mimic human gangliosides because more

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GBS cases occurred after swine flu vaccination compared to the occurrence of GBS in the
unvaccinated population. Ex. 146, at 227. They tested swine flu vaccine and flu vaccines
manufactured for the 1991-1992 and 2004-2005 flu seasons in mice. Id. They did not detect
anti-hemagglutinin antibodies on day zero but they detected significantly increased titers on days
21 and 35. Id. at 228. The authors discovered no contamination from C. jejuni, but all three
vaccines, i.e., swine flu, and flu vaccine from 1991-1992 and 2004-2005, induced IgG and IgM
antibodies to gangliosides even though the flu vaccines for 1991-1992 and 2004-2005 did not
manifest an increased incidence of GBS among the vaccinated. Id. at 230. The authors
speculate that low levels of viral neuraminidase (“NA”) in the 1976 swine flu vaccine may have
allowed sufficient sialic acid to remain bound to viral hemagglutinin (“HA”) forming a sialic
acid-HA complex that mimicked human ganglioside. Id. at 231. They state higher levels of viral
NA in other flu vaccines could be sufficient to reduce the amount of sialic acid-HA complex so
that the vaccine was less immunogenic and did not trigger GBS as swine flu vaccine did. They
conclude that the immunogenicity of HA differs among flu viral strains and that was the reason
that swine flu vaccine had different immunogenic properties than other flu vaccines, resulting in
a more potent anti-ganglioside antibody response and GBS in susceptible recipients of swine flu
vaccine compared to those receiving other flu vaccines. Id. This explains to the authors why “it
has been difficult to establish a link between GBS and influenza vaccine-related GBS in recent
years.” Id. Dr. Steinman ignores in his report (Ex. 141, at 6) the conclusion of Nachamkin and
his co-authors that only swine flu vaccine resulted in a greater incidence of GBS and subsequent
flu vaccines have not resulted in a greater incidence of GBS than above baseline.
        Petitioner filed as reference 11 to Dr. Steinman’s fourth supplemental report (Ex. 141) an
article by Silva Markovic-Plese et al., High Level of Cross-Reactivity in Influenza Virus
Hemagglutinin-Specific CD4+ T-cell Response: Implications for the Initiation of Autoimmune
Response in Multiple Sclerosis, 169 J IMMUNOL 31 (2005), as Exhibit 152. The authors focused
on T-cell receptor (“TCR”) cross-reactivity. Ex. 52, at 31. They recognize the pathogenic role
of autoreactive T-lymphocytes in initiating an autoimmune response in MS has yet to be
determined. Id. In order to study the requirements for molecular mimicry, the authors examined
the flexibility of TCR recognition and the degree of sequence homology required for a cross-
reactive immune response. Id. They identified a hierarchy of antigen specificities for a clone
generated against immunodominant flu virus hemagglutinin (“Flu-HA”) epitope within the
setting of an acute viral infection in someone with MS. Id. at 32. They noted a high stimulatory
potency of two MOG- and one CNPase-derived peptide as antigens capable of inducing cross-
reactive responses in a particular CD4+ T-cell clone (“TCC”). Id. at 37. The authors discovered
the CNPase-derived peptide had no homology with the native Flu-HA epitope and, therefore,
major histocompatibility complex (“MHC”) or TCR binding motif searches would not detect it.
They concluded that molecular mimicry, although it occurs frequently, leads to autoimmune
disease only in the context of chronic local inflammation, the presentation of self-antigens, and a
sufficient number of autoreactive T-cells. Id. Dr. Steinman, at page 17 of his fourth
supplemental report, uses the Markovic-Plese article to support his view that the 2009 flu
vaccine caused a reaction to petitioner’s myelin. He omits Markovic-Plese’s conclusion that the
CNPase-derived peptide had no homology to influenza virus A. Dr. Steinman also does not
include Markovic-Plese’s caveat that molecular mimicry would occur only in the context of
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chronic local inflammation, the presentation of self-antigens, and a sufficient number of
autoreactive T-cells.
        Petitioner filed a 1974 article to which Dr. Steinman referred in his fourth supplemental
report (Ex. 141) on pages 20-21, although he did not list it as a reference, by Charles David
Marsden & M.J.G. Harrison, Idiopathic Torsion Dystonia (Dystonia Musculorum Deformans).
A Review of Forty-Two Patients, 97 BRAIN 793 (1974), as Exhibit 170. The authors state it is
frequently an inherited disease beginning in childhood and relentlessly progressive so that the
patient is inevitably crippled by grotesque involuntary movements and postures by the time he or
she becomes an adult. Ex. 170, at 1. However, they note that the illness can vary in severity, age
of onset, and prognosis. Id. In order to participate in the authors’ study, someone could not have
evidence of cerebellar or sensory deficit on examination. Id. at 2. The authors studied 42
patients. The most common symptom was the difficulty in using one or both arms. Id. at 3.
(Petitioner complained more about her legs than her arms.) The second most common feature
was gait abnormality. Id. at 4. One-third of the patients were bed- or chair-bound. Id. at 6.
Intelligence, personality and memory appeared unaffected in all 42 patients. Id. at 7. (Petitioner
complained of cognitive impairment and decreased memory.) In their adult cases, only two
patients (both younger than 21) had problems with gait disturbance. Id. at 9. (Petitioner’s
primary manifestation was gait disturbance.) The authors state adult onset dystonia has a
relatively benign prognosis. Id. at 10.
        Before the hearing, respondent filed an article by Ting Lei et al., Anti-Ganglioside
Antibodies Were Not Detected in Human Subjects Infected with or Vaccinated Against 2009
Pandemic Influenza A (H1N1) Virus, 30 VACCINE 2605 (2012), as Exhibit OOO. The authors
attempted to find anti-ganglioside antibodies in humans and mice vaccinated against 2009
pandemic H1N1 flu virus. Ex. OOO, at 2606. Eight of the persons had post-vaccination GBS,
yet the authors did not detect anti-ganglioside antibodies in them or in the vaccinated mice. Id.
at 2609. The authors also checked for anti-ganglioside antibodies in people infected with 2009
H1N1 virus and did not detect anti-ganglioside antibodies. Id. They state, “Our work did not
support the model in which influenza vaccines induce anti-[ganglioside] antibodies in many
recipients, which subsequently cause GBS in a small subset of individuals.” Id. They also state
that GBS associated with flu virus infection or flu vaccination might be pathologically different
from GBS associated with an infection such as Campylobacter jejuni or another pathogen, in
which anti-ganglioside antibodies were more frequently detected. Id.
        On June 18, 2016, after the hearing held from June 14-17, 2016, petitioner filed
additional articles marked during the hearing. One was by Satish R. Raj et al., Blood Volume
Perturbations in the Postural Tachycardia Syndrome, 334 AM J MED SCI 57 (2007), as Exhibit
176. The authors state that patients with POTS have chronic symptoms lasting at least six
months, consisting of rapid palpitation, exercise intolerance, lightheadedness, extreme fatigue,
and mental clouding. Ex. 176, at 57. They have an increase in heart rate of at least 30 beats/min
within 5 to 30 minutes of assuming an upright posture which should occur in the absence of
orthostatic hypotension, i.e., a fall in blood pressure >20/10mm Hg. The authors also state many
patients with POTS have low blood volume. Id. The authors theorize that abnormalities in the

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renin-angiotensin-aldosterone axis may play a role in the pathophysiology of POTS by
contributing to hypovolemia, perhaps by impaired sodium retention. Id. at 58. They trace
perturbations in the renin-aldosterone system to partial sympathetic denervation involving the
kidney, an explanation consistent with the partial dysautonomia hypothesis for some patients
with POTS. Id. The recommendation to increase salt in the diet and intake of water is
commonly made for POTS patients.
        On October 14, 2016, petitioner filed case reports that Dr. Steinman listed as references
4, 5, and 6 in his sixth supplemental report (Ex. 191). The first reference is a case report by Yi-
Ting Hsu et al., Polyglandular Autoimmune Syndrome Type 4 with GAD Antibody and
Dystonia, 114 CLIN NEURO & NEUROSURG 1024 (2012), as Exhibit 194. A 20-year-old man had
limb twisting for four years, type 1 diabetes mellitus, right hand and left leg twisting triggered by
action or postural maintenance, alopecia and skin vitiligo, myasthenia gravis, and action-
triggered left hand twisting movement. Ex. 194, at 1024. Polyglandular autoimmune syndrome
(“PAS”) is reported to be associated with various extrapyramidal disorders. Id. at 1026. The
patient’s brain MRI showed striatal necrosis. (Petitioner does not have polyglandular
autoimmune syndrome or striatal necrosis of her brain.) The authors mention that nearly all
patients with stiff person syndrome, cerebellar ataxia, epilepsy or myoclonus are affected by
polyglandular autoimmune syndrome. (Petitioner does not have stiff person syndrome,
cerebellar ataxia, epilepsy or myoclonus.) Interestingly, the authors state that their patient’s
dystonia was poorly responsive to immunotherapy, implying that his immune-mediated cause of
dystonia was different than that of myasthenia gravis, vitiligo, or alopecia in PAS. Id.
       The second reference is a case report by Jana Kenda et al., (Pseudo)hemidystonia
Associated with Anti-Glutamic Acid Decarboxylase Antibodies – A Case Report, 22 EUR J NEUR
1573 (2015), as Exhibit 195. A 55-year-old woman with type 1 diabetes mellitus, chronic
lymphocytic thyroiditis, and vitiligo presented with abnormal painful posturing of the left
hemibody. She had a high titer of autoantibodies against GAD in both her CSF and serum. She
was diagnosed with stiff person syndrome. Id. The authors mention pseudodystonia which is
abnormal postures of body parts not caused by disorders of basal ganglia. Id. at 1574. Petitioner
does not have any disorder of her basal ganglia.
        The third reference is a “short report” by Angela Vincent et al., Antibodies to 125I-
glutamic acid decarboxylase in patients with stiff man syndrome, 62 J NEUR NEUROSUR & PSYCH
395 (1997), as Exhibit 196. The authors state stiff man syndrome involves muscle rigidity and
cramps resulting from immune-mediated inhibition of GABAergic neuron function. Ex. 196, at
395. Some cases occur with type 1 diabetes mellitus and others are paraneoplastic, with breast
tumors being most common. Anti-GAD antibodies are present in about 40 percent of patients
with stiff man syndrome. Id. Of 15 patients with myasthenia gravis and 30 with acquired
neuromyotonia, only one patient had clearly raised anti-GAD antibodies (this patient had
neuromyotonia and a thymoma). Id. at 396-97. (Petitioner has not been diagnosed with
neuromyotonia. She does not have a thymoma.) Interestingly, the authors found no anti-GAD
antibodies among 15 patients with myasthenia gravis and only one patient out of 30 with
acquired myotonia (and a thymoma) who had raised anti-GAD antibodies. Dr. Steinman

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emphasizes in his fifth supplemental report (Ex. 191) how petitioner’s positive anti-GAD
antibodies are a basis for many of petitioner’s problems. Ex. 191, at 10. Dr. Steinman does not
specify what those many problems are, but this short report does not provide support for any
correlation between anti-GAD antibodies and myasthenia gravis.
         Dr. Steinman has an additional reference to a case report in his sixth supplemental expert
report to emphasize that people with stiff man syndrome are frequently diagnosed as having a
psychogenic movement disorder. Ex. 191, at 11. But that does not mean that someone who has
a psychogenic movement disorder actually has stiff man syndrome. The case report petitioner
filed is by E. Andreadou et al., Stiff Person Syndrome: Avoiding Misdiagnosis, 28 NEUROL SCI
35 (2007), as Exhibit 197. A 41-year-old woman had spasms and intense painless clonic jerks of
her trunk and limbs lasting 30 minutes to two hours without impairment of consciousness. Ex.
197, at 35. She had profuse sweating and tachycardia. Id. Her EMG was abnormal, showing
spontaneous involuntary normal motor unit potentials in lumbar paraspinal and abdominal
muscles and in lower limbs in agonist and antagonist muscles simultaneously. Id. at 36. She had
anti-GAD65 antibodies in her blood. Id. Petitioner never had an abnormal EMG.
        Respondent filed as reference 4 to Dr. Whitton’s third supplemental expert report (Ex.
ZZZ) a report of two cases by Benjamin Lichtiger & Karen Rogge, Spurious Serologic Test
Results in Patients Receiving Infusions of Intravenous Immune Gammaglobulin, 115 ARCH
PATHOL LAB MED 467 (1991), as Exhibit DDDD. The authors state intravenous immune
gammaglobulin is a concentrate of IgG coming from the plasma of a large number of donors.
Ex. DDDD, at 467. People who undergo this therapy may test falsely positive for antibodies that
are in the donor plasma. Id.
         Respondent filed as reference 4 to Dr. Lancaster’s third supplemental expert report (Ex.
FFFF) a report of two cases by Abbas Bagheri et al., Psychogenic Unilateral Pseudoptosis, 31
OPHTHAL PLAST RECONSTR SURG e55 (2015), as Exhibit KKKK. The first case was a 21-year-
old man with unilateral ptosis which occurred suddenly on his left side two weeks earlier. Ex.
KKKK, at e55. He was treated by a psychiatrist and his symptoms spontaneously disappeared.
Id. at e56. The second case was a 10-year-old girl with left upper eyelid ptosis for six months.
She had stress in school. The doctors administered placebo intravenous saline injection and her
symptoms almost completely disappeared, only to recur a few hours later. She was referred to a
pediatric psychologist who treated her for conversion disorder. Two months later, she had
complete recovery. Id. The authors note that conversion symptoms are clearly associated with
psychological problems and environmental stresses. On clinical examination, the doctors could
not find anything neurologically wrong. Id.
        Respondent filed as reference 5 to Dr. Lancaster’s third expert report (Ex. FFFF) a report
of three cases by Jeanette W. Hop et al., Psychogenic Pseudoptosis, 244 J NEUROL 623 (1997), as
Exhibit LLLL. The first case involved a 39-year-old engineer who developed ptosis of his left
eye eight years before admission, without any other symptoms. Ex. LLLL, at 623. Episodes of
severe drooping alternated with months without complaint. When administered a placebo of
saline, his ptosis cleared. He had been under stress and underwent relaxation therapy. After
three months, his ptosis completely disappeared.

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        The second case was a 30-year-old nurse who complained of eight months of tiredness,
difficulty with walking, a funny sensation in her head (resulting three times in a brief loss of
consciousness without any witnesses), swallowing difficulties, and concentration problems. For
three months, she noticed a persistent lowering of her left upper eyelid which first started after a
headache. When tired, she had diplopia while reading. All symptoms worsened in the evening.
Id. Extensive medical and neurological investigation did not show any abnormality. Id. at 624.
She was diagnosed with generalized somatization disorder and hysterical ptosis. The doctors
recommended a program in behavior. But, two years and three hospitals later, her complaints
and ptosis remained unchanged. After a pseudo-epileptic fit, she was not able to return to work.
Id.
        The third case was a 48-year-old woman who complained of episodes of abrupt
involuntary closure of her left eye. At first, this resolved spontaneously after a few days, but
during the next four months, the ptosis increased and she had double vision when looking to the
left. She also complained of right calf pain, drowsiness, difficulty walking, transient attacks of
loss of sensation in her left arm and leg, and episodes of transient loss of vision in both eyes,
preceded by flashing lights. Testing did not show abnormalities. Her symptoms were
unchanged until a follow-up visit three months later. Her husband had recurrent and bilateral
facial palsies. The doctors opined the patient had some role copying contributing to her
conversion disorder. She was treated for thrombocytosis which had been detected earlier in the
year and six months later, her platelet count was normal. Her ptosis also almost completely
disappeared without specific therapy. Id. The authors conclude that psychological factors
contribute to conversion disorder. Id.
        Petitioner filed as reference 7 to Dr. Steinman’s seventh supplemental expert report (Ex.
198) a case report by Andrea Maier et al., GAD Antibodies as Key Link Between Chronic
Intestinal Pseudoobstruction, Autonomic Neuropathy, and Limb Stiffness in a Nondiabetic
Patient. A CARE-Compliant Case Report and Review of the Literature, 94 MEDICINE 1 (2015),
as Exhibit 203. At age 28, the patient had her first symptoms of achalasia152 and early satiety
requiring her to eat more than five meals a day. Ex. 203, at 1. She had constipation with
intervals of three or more days, leading to her using laxatives. She fainted several times and
avoided standing upright for more than 15 minutes. Severe gastroesophageal dysmotility and
dysphagia led to a weight loss of 15kg153 in one and one-half years. Id. When she was 36 years
old, intestinal dysmotility had advanced to chronic intestinal pseudoobstruction (“CIP”) with
complete paresis of the intestinal passage and severe abdominal pain. She had a percutaneous
enteral tube and stoma inserted. Due to abnormal urinary retention, she had to catheterize herself
four to six times a day. Dizziness and palpitations reduced her orthostatic tolerance to less than
10 minutes. Id.

152
    Achalasia is “failure of the smooth muscle fibers of the gastrointestinal tract to relax at a point of junction of one
part with another; usually used to denote esophageal achalasia.” Dorland’s at 14.
153
    Fifteen kilograms is 33 pounds. CALCULATEME, https://www.calculateme.com/weight/kilograms-to-pounds/15
(last visited Mar. 22, 2019).

                                                           136
         She developed dry eyes, dry mouth, dry, irritable skin with recurrent eczema, and
difficulties in visual adaptation to darkness. Id. at 1-2. Occasionally she felt paresthesia and
pain in her legs. Id. at 2. At the age of 37, she presented to the autonomic clinic of the authors
with emaciation and spasms in her right leg. Her cranial nerves were intact except for an
anisocoria154 of one mm right < left eye and a reduced dilation of the right pupil in the dark. Her
sensation was normal, including pain, light touch, vibration and proprioception. Deep tendon
reflexes mainly of the right leg were increased. Id. Moving her legs passively was painful and
difficult because her leg muscle tone was increased. Id. at 2-3. Testing of her autonomic
nervous functions showed she had a right-sided Horner syndrome155 of postganglionic156 origin.
Id. at 3. The patient had bilateral sicca syndrome.157 She had detrusor hypocontractility with
urinary retention and an enormous delay in the barium enema passage. Galvanic skin responses
were delayed in hands and feet bilaterally. Head-up tilting at 70 degrees revealed a postural
tachycardia with a heart rate increasing by 35 bpm. Her time upright was limited to five and
one-half minutes due to presyncopal complaints. Id.
        Nerve conduction studies, including somatosensory and motor evoked potentials, were
normal. Repeated neuromuscular stimulation did not provide a basis for diagnosing the patient
with myasthenia gravis or Lambert-Eaton myasthenic syndrome. However, the patient was
diagnosed with stiff limb syndrome because of spontaneous grouped neuromyotonic discharges
of motor units in her quadriceps and biceps femoris muscles of the right leg. Repeated
measurements of her GAD65 antibodies were between 24 and 197IE/mL when the normal result
should be <10IE/mL. The doctors administered IVIG at intervals of four weeks. Id. After three
cycles of IVIG, her ability to stand rose from five to ten minutes and her weight stabilized. Id. at
3-4. Self-catheterization was reduced to two times a day. Id. at 4. This improvement remained
for about three weeks, but then bladder retention recurred, her weight dropped again, and her gait
unsteadiness and leg muscle stiffness increased. By adding prednisolone to the monthly IVIG,
the patient improved.
       The authors view this patient’s condition as autoimmune. Id. They say GAD antibodies
are considered organ specific and are usually associated with diabetes mellitus, although they can
be found in nondiabetic patients such as the subject of the case report. They note that GAD
antibodies are rare findings in patients with predominant enteric dysmotility. Id. (Petitioner did
not have CIP, anhidrosis, spontaneous grouped neuromyotonic discharges, a brainstem lesion
leading to Horner’s syndrome, or urinary retention.)

154
    Anisocoria is “inequality in diameter of the pupils.” Dorland’s at 93.
155
    Horner syndrome is “sinking in of the eyeball, ptosis of the upper eyelid, slight elevation of the lower lid,
constriction of the pupil, narrowing of the palpebral fissure, and anhidrosis and flushing of the affected side of the
face; caused by a brainstem lesion on the ipsilateral side that interrupts sympathetic nerve fibers.” Dorland’s at
1833.
156
    Postganglionic means “situated posterior or distal to a ganglion; said especially of autonomic nerve fibers so
located.” Dorland’s at 1502.
157
    Sicca syndrome is “keratoconjunctivitis and xerostomia without connective tissue disease.” Dorland’s at 1848.
Keratoconjunctivitis is “inflammation of the cornea and conjunctiva.” Id. at 980. Conjunctiva is “the delicate
membrane that lines the eyelids and covers the exposed surface of the sclera.” Id. at 405. Xerostomia is “dryness of
the mouth from salivary gland dysfunction.” Id. at 2087.

                                                         137
         Petitioner filed as reference 1 to Dr. Steinman’s ninth supplemental report (Ex. 208), an
article by Midhat S. Farooqui et al., Therapeutic Plasma Exchange and Immunosuppressive
Therapy in a Patient with Anti-GAD Antibody-Related Epilepsy: Quantification of the Antibody
Response, 30 J APHERESIS 8 (205), as Exhibit 209. One of the co-authors of this article is
respondent’s expert Dr. Lancaster. The women whom the authors describe was 23 years old,
coming to the authors’ hospital because of increasing seizure frequency over the prior few
weeks. Ex. 209, at 9. Her seizures were generalized tonic-clonic typically preceded by an aura
of anxiety and sometimes déjà vu. They usually occurred at night and lasted for about one to
two minutes, followed by five minutes of confusion. Id. In the month prior to her going to the
hospital, the patient had about one seizure a week which progressed to one per day. Id. at 9-10.
The patient had been diagnosed with epilepsy four years earlier. Id. at 10. EEG showed frequent
left temporal epileptiform discharges with intermittent left temporal slowing. A later MRI
showed T2 hyperintensity in her left mesial temporal lobe and a small area of T2 hyperintensity
in her right temporal lobe. Id. She had elevated anti-GAD antibodies in her serum, measuring
115,900 IU/ml at her highest level and, after completing five sessions of treatment with
therapeutic plasma exchange (“TPE”) and immunosuppressive therapy (mycophenolate mofetil
for two days followed by oral prednisone), her lowest level of anti-GAD antibodies was
3,970IU/ml. Id. at 11. The normal level of anti-GAD antibodies is ≤5IU/ml. Id. at 10.
        Over these five treatments with TPE, the patient was seizure-free. Id. The patient’s
decrease in GAD autoantibody burden and decline in serum reactivity to GAD antigens
correlated with clinical recovery. Id. at 11. She went from one seizure per day to being seizure-
free over the next month. After that month, however, her seizures recurred. Id. The authors
conclude that the patient’s seizure disorder had an immune-mediated component, noting that
anti-GAD antibodies have been linked to a variety of neurological syndromes including stiff
person syndrome, cerebellar ataxia, limbic encephalitis, and epilepsy. Id. at 11, 12. They also
note that through immunostaining, they characterized the patient’s GAD as the likely dominant
neuronal autoantigen for this patient who had a progressive loss of GAD reactivity in her sera to
neurons while she underwent TPE treatments. Id. at 13. The authors cannot conclude however
whether TPE could be used as maintenance treatment as part of her long-term therapy. Id.
        The undersigned fails to see the relevancy of this article to petitioner herein. Petitioner
never had seizures. All her EEGs and brain MRIs were normal. She does not have any of the
neurological syndromes with which anti-GAD antibodies are associated, i.e., stiff person
syndrome, cerebellar ataxia, limbic encephalitis, and epilepsy. Moreover, her elevation above
the ≤5IU/ml normal level of anti-GAD antibodies, ranging from 6IU/ml to 37IU/ml, are
infinitesimally smaller that the patient’s anti-GAD antibodies in this article, ranging from a high
of 115,900IU/ml to 3,970IU/ml. Thus, petitioner has neither the neurologic illnesses with which
anti-GAD antibodies are associated nor the high titers of anti-GAD antibodies which people with
these neurologic illnesses have.
       Respondent filed as reference 2 to Dr. Whitton’s fourth supplemental expert report (Ex.
MMMM) an article by Beth B. Murinson, Stiff-Person Syndrome, 10 THE NEUROLOGIST 131
(2004), as Exhibit OOOO. The author lists the characteristics of stiff person syndrome. Ex.

                                               138
OOOO, at 132. The legs and spine are almost always affected. The patient will hold the leg in
stiff extension making ambulation awkward. The most important clinical sign is increased
lumbar lordosis. The abnormal postures are due to sustained muscle contraction. Abdominal
muscles are frequently involved. Arms, when involved, may assume a flexed posture.
Superimposed spasms can be overwhelming, making it impossible for a doctor performing a
physical examination on the patient to bend or move the stiffened limb. The syndrome is
associated with stress and results in numerous falls. These falls are described as statue-like or
log-like. Id. Onset of stiff person syndrome is typically in middle age. Id. at 133. The classic
EMG finding of stiff person disease is continuous motor unit activity. Id. at 135.
         Petitioner did not have any of the characteristics of stiff person syndrome as depicted in
this article. Petitioner complained of weakness. She would drop an arm in seconds. She would
weave when walking, as if she were about to fall, but she would not fall. No doctor noted
petitioner had lumbar lordosis. Her EMG was normal.
        Respondent filed as reference 2 to Dr. Lancaster’s third supplemental expert report (Ex.
QQQQ) an article by Wei Hao et al., Epitope-Specific Glutamic Acid Decarboxylase-65
Autoantibodies in Intravenous Immunoglobulin Preparations, 9 TRANSFUS MED 307 (1999), as
Exhibit SSSS. The authors report there are autoantibodies to GAD65 present in IVIG. Ex.
SSSS, at 307. They tested six preparations of IVIG for the presence of GAD65 antibodies and
found GAD65 antibodies in all six. Id. They also tested to see if the antibodies to GAD65 in
IVIG were reactive in humans (as well as in rats and mice) and found that they were. Id. The
authors note that the presence of GAD65 autoantibodies is not surprising since about one to two
percent of healthy normal individuals may have GAD65 autoantibodies in their plasma. Id. at
309. They note that since IVIG is used as a treatment for patients with stiff person syndrome, a
possible harmful effect may be caused by the administration of more GAD65 autoantibodies.
Another possibility is a beneficial effect in generating an idiotypic immune response. They
suggest screening commercial preparations of IVIG for GAD65 autoantibodies before treating
patients with stiff person syndrome to detect the presence of GAD65 autoantibodies. Id.
         Respondent filed as reference 3 to Dr. Lancaster’s third supplemental expert report (Ex.
QQQQ) an article by Jeffrey L. Kishiyama et al., A Multicenter, Randomized, Double-Blind,
Placebo-Controlled Trial of High-Dose Intravenous Immunoglobulin for Oral Corticosteroid-
Dependent Asthma, 91 CLIN IMMUNOL 126 (1999), as Exhibit TTTT. The authors compared the
efficacy of high-dose IVIG treatment of severe, steroid-dependent asthma with placebo
consisting of albumin and discovered no significant difference in treatment effects of IVIG and
placebo. Ex. TTTT, at 126, 131. The authors did however note the severe adverse effects of
IVIG treatment which can include aseptic meningitis and severe headaches. Id. at 131. Because
of the cost of adverse effects of IVIG therapy, “clinical efficacy would need to be dramatic to
justify such therapy.” Id. They conclude, “In summary, in this controlled study, high doses of
IVIG did not demonstrate a clinically or statistically significant advantage over placebo
(albumin) infusions for the treatment of corticosteroid-dependent asthma.” Id. at 132.
                                          Other Filings

                                                139
       Respondent filed as Exhibit W the results of an 8K race held on October 17, 2009, which
is almost eight weeks after petitioner received flu vaccine. Petitioner came in 179th out of 220
runners with a time of 56 minutes and 13 seconds. Ex. W, at 4. Eight kilometers is almost five
miles, which means petitioner ran at a pace of about a mile in about 11 minutes.
        Respondent filed as Exhibit X a page from a podcast edition of The Robert Scott Bell158
Show, on the website Vactruth.com, dated November 5, 2009, which is 10 and ½ weeks after
petitioner received flu vaccine. Mr. Bell interviews Dr. Rashid Buttar who states petitioner was
now cured. Ex. X, at 1. After stating Dr. Buttar reversed a supposedly incurable neurological
adverse event reaction, Mr. Bell refers the listeners to petitioner’s own website which includes
her name and “my story.” Id. at 2.
       Respondent filed as Exhibit Y pages from Age of Autism, NFL Cheerleader Disabled by
2009 Flu Shot on Road to Recovery, (Nov. 6, 2009), http://www.ageofautism.com/2009/11/nfl-
cheerleader-disabled-by-2009-flu-shot-on-road-to-recovery.html. It shows petitioner in her
Redskins uniform, smiling at the camera. It states:
                 The vibrant, 25-year-old Washington Redskins Cheerleader
                 Ambassador has a website to tell her story and keep well-wishers
                 from around the world informed of her progress as well as to
                 promote “true informed consent.”
Ex. Y, at 2. The article says petitioner’s story made headlines both in the US and abroad, with
videos explaining her disorder attracting millions of viewers on YouTube. Id. It continues:
                 The responses she has received have been overwhelmingly
                 supportive, encouraging, and informative. Celebrity couple Jenny
                 McCarthy and Jim Carrey helped point [petitioner] in the right
                 direction through Generation Rescue, a non-profit organization
                 dedicated to preventing and reversing autism.
                 The treatments with Dr. Buttar at the Center for Advanced
                 Medicine and Clinical Research in Charlotte, NC are working, and
                 the results are nothing short of amazing. [Petitioner] can now walk
                 and talk normally throughout the vast majority of the day and the
                 seizures/convulsions have significantly decreased. Although her
                 full recovery will take an undetermined amount of time, her family
                 is now for the first time, convinced she will make a complete
                 recovery. She is now more than ever driven by a desire to educate
                 others to be informed of the potential side effects caused by
                 vaccines and prevent others from suffering a similar fate.

158
   “Robert Scott Bell tackles the tough issues and shows no fear when confronting government and corporate bullies
who would stand in the way of health freedom. You will be amazed by the amount of information about healing
that is kept secret from you and what you can do to learn more about it.” GCNLIVE, rss.gcnlive.com/RobertScottBell
(last visited Feb. 25, 2019).

                                                       140
               Visitors to her new website [listing it] will find regular updates on
               her progress, helpful details on her treatment and valuable
               information on the importance of “informed consent” – truly
               knowing ALL of the options before making important medical
               decisions.
               “I set up the site to tell my story and warn people of the
               neurological side effects that can result from vaccinations,”
               [petitioner] said, “Especially knowing that in the majority of cases,
               these stories are seldom heard outside of immediate families and
               friends.” Visit [petitioner’s website] for more information.
Id.
       On October 21, 2011, petitioner left the following comment on a website called
Operation Jack:
               I was injured too from a flu vaccine in 2009. They call it autism,
               but in reality it’s really brain damage. I now exhibit a lot of the
               same cognitive issues that someone with autism would have. I
               have brain vasculitis and a shrunken cerebellum all from my
               mistake to become vaccinated. I however can still run and plan on
               running in this year’s Operation for [sic] Jack race. . . .
Operation Jack, Picturing Regression (Aug. 24, 2011), http://www.operationjack.org/picturing-
regression.
                                            HEARING
        For the four days of hearing, Robert J. Krakow, who was petitioner’s first attorney,
assisted Lisa A. Roquemore, who is petitioner’s current attorney. Tr. at 2. For respondent,
Debra A. Filteau Begley assisted Justine E. Walters. Id. at 3.
                                     Petitioner’s Testimony
        Petitioner testified first. Id. at 18. She explained that she chose a French name for her
last name at random in December 2012 because she was divorced twice and did not want to use
her maiden name since, in 2009, the media paid a lot of unkind and unhelpful attention to her
symptoms and a lot of people attacked her on social media. Id. at 19. She went public initially
when a co-worker at AOL asked to do a story in the local newspaper he worked for and, from
there, “it kind of took off.” Id. at 20. Petitioner said her original reasoning for going public was
she thought her batch of vaccine was tainted and she wanted to warn others that they should
probably look into that particular batch. Id.
        Petitioner went through her education. She was a junior studying for a bachelor’s degree
in finance and economics at night. She started working at AOL at 18 as a secretary. Id. She
says she quickly moved up the ranks and became a communications marketing manager. She
also worked at Morgan Stanley as a securities representative. Id. She holds a series 7, 66, 31

                                                141
and an insurance license to trade annuities. Id. at 21. She also has a real estate license. She and
her second husband divorced in February 2011. Id.
        Petitioner described her health before receiving the flu vaccination in 2009 as excellent.
She was training for a 5K race, which is about three miles, but she was not really able to do a lot
of training given her work schedule. She was about to be promoted at work.
         Petitioner said she had seasonal allergies in the spring and fall. Id. at 22. AOL had a
vitality wellness program and she would submit health milestones, such as running 5Ks, in the
hope of getting a vacation. Her seasonal allergies caused a sinus infection that became
bronchitis. Id. She was still going to work 50 hours a week and going to the gym with her
bronchitis and cough. Id. at 23. For a couple of months prior to the flu vaccination, the bulk of
petitioner’s activities were running three to five miles a week, exercising, and going to the gym.
Id. at 25. In her spare time, she read or studied. Id. at 26. She eventually wanted to get back
into the finance sector and start her own brokerage someday. Id. at 26.
         Petitioner joined the Washington Redskins Cheerleader Ambassadors in April 2009.
Cheerleaders were a dancing squad specifically meant to entertain on the field. However,
cheerleader ambassadors were specifically meant to go around to the suite owners and interact
with them. Id. To become an ambassador, you had to have a good background, good education,
and speak very well because you were going to speak with CEOs of corporations and high-level
executives in these suites. Id. at 26-27. You had to be able to articulate well and speak with
them. Id. at 27. An ambassador needed a lot of intelligence, and the ability to do public
relations and communication. Petitioner said she wanted to be an ambassador because she hoped
to start a brokerage someday. She thought being an ambassador would be a good networking
opportunity to find investors to eventually help her start her own brokerage. Her job as an
ambassador was on Sundays, while she still worked at AOL. Id.
        Petitioner said she got a flu vaccination in August 2009 and remembers the day because
she and her then-husband were going to a barbecue that day and stopped at a Safeway to buy
dessert. Id. at 28. She also felt bad that she was missing her younger brother’s birthday that day.
In addition, the flu vaccination would give her 200 more points for the AOL health wellness
program. Id. She remembers her resting heart rate at the time was in the 60s. Id. at 29. Her
blood pressure was usually around 100. Id.
         Starting on September 3, 2009, she woke up and felt unwell, hot, sweaty, and nauseated.
Id. at 29-30. Her symptoms worsened during the day. Id. at 30. She remembers it was
September 3, 2009 because that was her and her then-husband’s third wedding anniversary and
they were supposed to go out to dinner. She did go to the dinner and powered through it. She
went to work that day and powered through it. Id. After dinner, she was nauseated and felt
really lightheaded. Id. at 31. Four people lived in the house with her: her husband, her brother,
her sister, and a roommate. None of them was ill and no one at work was ill. Id. She ate dinner
as she normally would, but she was too dizzy to drive home. Id. at 31-32. That evening, her
nausea worsened and she was sweating. Id. at 32. She started feeling muscle pains as if
someone were tearing a knife through all her muscles. Id.

                                                142
        On September 12, 2009 she went to the hospital. That morning, she ate a burrito for
breakfast and water and an energy drink. After 20-30 minutes, she was sitting on the couch and
felt nauseated, lightheaded, and really cold. She “kind of fainted sitting on the couch.” Id. She
got up and she got worse with more lightheadedness and dizziness. Id. She collapsed and her
then-husband and roommate rushed her to urgent care. Id. at 33. This was a Saturday. She
started shaking and had a hard time breathing. Id. She stated she had never fainted before her
flu vaccination. Id. at 34.
       At the hospital, she was started on IV saline and felt slightly better. She was diagnosed
with rhabdomyolysis. After the IV, she felt much better. She had no problems keeping food
down. She was on IV fluids for three or four days. Id.
         The day after she was discharged from the hospital, she went back to work. Id. at 35.
She felt pretty good on the day of discharge. A day later, her symptoms started to return. She
felt extremely lethargic and fatigued and she did not have any appetite or very little appetite. A
day or two later, she started having dizziness and almost fainted after she had eaten some grapes.
Id.
        On the second or third day back to work, she was sitting at her desk eating grapes and a
coworker came up to her. Id. at 36. Petitioner was dizzy and lightheaded. The coworker
grabbed her then-husband because he and petitioner worked in the same department together at
AOL. Petitioner stood up and became lightheaded and dizzy. She had to sit down. Her then-
husband took her to the hospital. Id. Between the two hospitalizations of September 12 and 17,
she had no appetite at all and just ate very small meals. She had problems with nausea and
almost vomited some of the time. Id. at 37. On September 17, 2009, she noticed heart rate
issues. Her heart rate was a lot higher than it had ever been. Id.
        In the hospital on September 17th, she was told she had a high ANA. Id. at 38. When she
was discharged, her symptoms worsened. Id. at 39. It was harder for her to eat. Her appetite
was almost completely gone. She had more dizziness and fainting. A few days after discharge,
she had walking problems and speech problems along with fainting, nausea, and eating
problems. Her walking problems consisted of feeling as if her legs were weak and buckling
when she tried to get up. It started when she went to have a spinal tap. She was all right in the
beginning of the morning, but halfway through the morning, her legs started to buckle and she
was losing muscle control. Id. Her speech issues happened a day or two after that and she thinks
it was stuttering. Id.
        On September 26th, she went back to the hospital because of the walking issues and the
dizziness. Id. at 40. A family friend who was a doctor said she could possibly have GBS and
told her to go to the emergency room of a hospital to have them assess her. At the hospital, she
started having breathing issues and they admitted her. Id. A nurse mentioned to an intern that
petitioner had an orthostatic issue when she got up. Id. at 40-41.
        Some of the hospital notes indicate petitioner was applying her makeup in the hospital.
Id. at 41. Petitioner explained she had more strength in the morning and could do her showering,
apply makeup, get ready, and had perhaps 30 minutes to an hour before she would start to lose

                                               143
muscle control. She said she came into the hospital but was unable to walk and had a commode
next to her hospital bed because she could not get up. She thinks what the hospital personnel
were “probably insinuating” is that she had makeup on that she could not wash off because she
could not get up to go to the bathroom. Id. She said she never at any time at any of her hospital
visits had makeup with her. Id. at 42. She said she would have makeup on before she went to
each hospital. Id.
        Petitioner said that, in general, she typically had about 30 minutes to an hour in the
mornings before any muscle issue “would kick in.” Id. Gradually, that became maybe 20
minutes and, later on, she would waken and almost have complete muscle problems in just a few
minutes. She had more strength in the morning. Id. Petitioner said that the personnel in the
hospital visit of September 26, 2009 did not seem to know what was happening and told her they
were stumped. Id. Her infectious disease doctor ran a series of tests and said there was no
infectious disorder. Id. at 42-43. He said she should see a neurologist. Id. at 43.
         Petitioner thought initially she had Lyme disease, but she tested negative for that. Her
doctor prescribed an antibiotic anyway, which she took, but it did not help her symptoms. Id.
She saw a psychologist during her hospital visit of September 26th to rule out conversion disorder
as a diagnosis. Id. The psychologist said she did not have conversion disorder and “passed the
test, so to speak.” Id.
        Petitioner explained the reference to her teenage bulimia in the psychologist’s notes. Id.
at 44. She only tried it because of friends but did not continue with it. Id. Petitioner had pain in
her esophagus like heartburn, but a sharper stabbing pain that began in mid-September around
September 16 or 17, 2009. Id. at 45-46. It occurred mostly after she ate. Id. at 46.
         After her September 26, 2009 hospitalization, the doctors said they could not figure out
what she had and she needed to follow up with her general practitioner. He said he was not
really sure what was going on but she still had a high ANA. Id. He recommended she go to
Johns Hopkins hospital for a diagnosis, which she did on October 2, 2009. At the time, she was
still having a lot of eating issues. When she arose in the morning, she had maybe 10-20 minutes
before she would have walking problems. They started to become almost a shaking movement.
Id. The weakness combined with jerky movements. Id. at 47. After only 20-30 minutes after
she ate, she would start getting dizzy and lightheaded. Then her speech became stuttering. She
could not recall when her speech became more slurred. She also had a high heart rate. Id. She
had one-word responses. It was hard to get out the words. She also had trouble breathing to
make each answer. Id.
        She also had trouble keeping food down. Id. at 47-48. When she tried to eat and move
her tongue, it would produce other muscle symptoms, a kind of weakness and jerky movement in
her neck. Id. at 48. When she attempted standing or sitting up, she would be dizzy and
lightheaded from a meal. Id.
        Petitioner said the personnel at Johns Hopkins told her she “was just having some kind of
reaction to the vaccine and that, hopefully, it would get better within six weeks.” Id. She saw a
physical therapist at Johns Hopkins who saw her walking and said that type of dystonia is easily

                                                144
treated by physical therapy and medication. Id. at 48-49. Petitioner said she was “kind of blown
away” because no one had diagnosed her until the physical therapist said she had dystonia. Id. at
49. Petitioner testified that after petitioner told the Johns Hopkins neurologist what the physical
therapist told her, he said petitioner should follow up with a neurologist and he would give her
medication, Klonopin, to help with dystonia. Its generic name is clonazepam. The reason the
Johns Hopkins neurologists gave for prescribing this was they thought she had some kind of
reaction to the vaccine and the drug would help. But the main reason was that earlier, in the
evening, they had prescribed Ativan to help her sleep. Id. When a phlebotomist came in to draw
blood, she was able to speak very fluently after the Ativan without any problem. Id. at 49-50. In
the morning, still on Ativan, she was able to walk briefly for a few minutes before she returned
to having trouble speaking and walking. Id.
        Petitioner explained that Klonopin is in the same family of drugs as Ativan, but an
alternative because Ativan made her too sleepy to function during the day. No one else had a
thought about an alternate diagnosis to dystonia. They just thought she had some reaction to the
vaccination. They did propose she could have some kind of stress and should follow up with a
general practitioner, a neurologist, a psychologist, and a physical therapist. Id.
       The physical therapist told petitioner about sensory tricks. Tr. at 51. When petitioner got
home, she went on the web and searched dystonia, finding a Mayo Clinic list of sensory tricks to
try. For example, for speech, she placed her hand on her chin to alleviate the muscle spasm.
Another sensory trick was to place pressure on her leg to alleviate some of the muscle spasms
there. These sensory tricks worked initially for her. Running would alleviate the dystonia. Id.
       Petitioner lost a considerable amount of weight. Id. Petitioner said that when the Johns
Hopkins neurologist Dr. Anjail Sharrief saw petitioner’s walking, Dr. Sharrief’s jaw dropped and
she looked like she had never seen anything like that before, but the physical therapist was just
the opposite and knew what petitioner had as soon as she saw it. Id. at 52. Petitioner and her
then-husband decided not to follow up with Dr. Sharrief when petitioner left Johns Hopkins and
wanted to find someone with a little more experience. Id. Petitioner said the Johns Hopkins
personnel told her Ativan would alleviate the symptoms of dystonia. Id. at 52-53. She had a lot
of insomnia at the time. Id. at 53.
         Petitioner said the publicity about her “took off into some kind of media circus.” After
the initial newspaper article with her former colleague, local news stations and national stations
started calling her and she committed doing a few of those and “it just became its own beast.”
Id.
        Petitioner went to see Dr. Cintron, a neurologist, in Reston, Virginia around October 15,
2009. Id. She said Dr. Cintron seemed to think she was having a reaction to the flu vaccination
and it was causing a movement disorder. Id. at 54. Later on, he said it looked like it was also
causing autonomic issues as well. Dr. Cintron did 30 minutes of a physical examination,
watching her walk, doing different tests, having her whisper and sing (she was able to do both
without having speech issues). Id. at 54-55. He recommended petitioner have IVIG treatment as
well as a medication and she never did either. Id. Because of the media attention, Stan Kurtz

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from Generation Rescue, “some whacky anti-vaccine group,” approached her and offered to help
cure her. In exchange, she would help them do a documentary. She said Stan Kurtz seemed
convincing and believed he could cure her of all her symptoms. She felt it might be a better
course of action since she had gone to so many hospitals and still did not have a treatment or an
answer to what was going on. Id. She stated she did not think she had autism. Id. at 55-56.
        On October 17, 2009, petitioner was getting ready to run a 5K or an 8K race. Id. at 57.
She was going to run three to five miles. Her symptoms were probably at their worst at that
point. She had trouble keeping food and water down. Her speech was horrible. She could get
out only one word at a time and if she tried too hard, her speech became slurred. She was having
walking issues. Whenever she ate or drank, she got lightheaded or dizzy. She did not want to do
that race on that particular day. Id. It was raining and cold. Id. at 58. But she said she had
committed to Generation Rescue and their documentary and they brought in film crews. Plus,
she had committed to friends who were going to help her run the race. She did not want to back
down on the commitment she made to them. Before this race, the last time she ran a race was
probably in August when she did a three-mile run. Id. Petitioner states she did not run for
exercise during that time period in September. Id. at 59. She discovered she could walk
backward by accident. Id.
        Petitioner states at this time, she had trouble chewing and swallowing even just liquids or
moving her tongue around. Id. at 60. It would worsen her muscle problems. It was not so much
the swallowing itself. It was the movement of her tongue. Id. Every time she tried to move her
tongue around to swallow, she would have speech issues and breathing problems. Id. at 60-61.
The undersigned asked petitioner if she were breathing through her mouth and she responded she
would just stop breathing. Id. at 61. She was not choking. It was almost like the muscles with
breathing stopped working and she could not physically get them to go on her own for a period
of a few seconds. Her breathing “would just start working after a few seconds.” Id. She would
stop breathing when she was eating or doing something strenuous like overexerting her muscles,
trying to talk when she could not talk or walk further than she could walk. This would bring on
these brief periods when she stopped breathing. Id. The undersigned asked petitioner if she
would faint and she said she could not quite recall if she would faint during these periods. Id. at
62.
         Petitioner then consulted her supplemental declaration, Exhibit 139, page 9, paragraph
30, video #409_0237_01, because Dr. Lancaster commented on that October 17, 2009 video in
his first expert report (Ex. H). Id. at 63. Petitioner said that her voice sounded more slurred than
what Dr. Lancaster described. Petitioner described it as if the muscles in her tongue were not
moving but were numb or more likely paralyzed. Id. at 67. She stated in paragraph 35 of her
supplemental declaration that her throat felt paralyzed with swallowing. Id. at 68. As soon as
she swallowed a liquid, she started feeling as if her lungs were paralyzed and she could not get
them to move. Id. When petitioner’s attorney asked her if it were her lungs, petitioner said,
“Well, the throat.” Id. at 68-69. She stopped breathing for a few seconds. Id. at 69. On October
17, 2009, it would be 10, 20 seconds. Id.

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        Ms. Roquemore asked petitioner if she agreed with Dr. Lancaster’s comments on video
#409_251_01 in her supplemental declaration, Ex. 139, page 12, paragraph 42. She said no.
When she reviewed the video, she was having difficulty eating the strawberries which had to be
cut up. She believes she had three or four bites before having trouble chewing and finishing the
food. Therefore, she was not chewing easily and not swallowing easily. For a brief moment, she
stopped breathing. Id. Then she started having shaking tremors. Id. at 70. Then her speech
became slurred. She concludes there was a lot more going on in this video than Dr. Lancaster
described in his expert report. Before all this, she would eat a whole pack of strawberries and
not cut them up. Id.
        Ms. Roquemore asked petitioner if she agreed with Dr. Lancaster’s comments on video
#409_258_01 in her supplemental declaration, Ex. 139, page 14, paragraph 49. Petitioner said
this video shows her explaining how she was having shortness of breath when she walked or ate.
Id. She would have stabbing pain in her ribs, hips, and knees. Id. at 71. In the video, she
describes how she had trouble eating and she was losing a lot of weight because as soon as food
“hit” her stomach, she felt sick. She also described in the video how when using her tongue to
eat or swallow, that caused her symptoms to worsen and how in the hospital, when she was given
IV fluids, she would feel a lot better and a lot of the symptoms would improve. She discussed
how she had a high heart rate. Id.
        Ms. Roquemore asked petitioner if she agreed with Dr. Lancaster’s comments about a
video she refers to in supplemental declaration, Ex. 139, page 14, paragraph 151 (without
identifying the video number). The video shows petitioner eating a large salad and Dr. Lancaster
said she did it easily. Petitioner protested that it was the opposite. She was trying to eat really
quickly because she figured if she could eat fast enough, then she would get the food down
before she had symptoms. Id. She said she could only get in three bites before she had trouble
chewing. Id. at 72. Petitioner stated the video shows her becoming weak, and having shaky
movements, tremors, and trouble breathing. When she tries to take another bite, she has
weakness and is shaky. Her then-husband tries to help feed her and, several minutes later, she
drinks water easily since she figured out that if she did not move her tongue and she was not
chewing, she could get liquids down okay. Then she explains that her face feels paralyzed or the
muscles feel as if they are not working. Later, others used a food processor to blend her salad so
she could try to eat it later. Id.
       Ms. Roquemore asked petitioner if she agreed with Dr. Lancaster’s comments on video
#409_0285_01 in her supplemental declaration, Ex. 139, page 16, paragraphs 58 and 59. Id. at
73. She said the video showed her nauseated and vomiting a small amount of pink liquid into a
bowl. She said she had really weak leg muscles in that video. She denied spitting any food up.
She said it was vomit. She was having a very hard time keeping food down. Id.
        Ms. Roquemore asked if October 19, 2009 was the first time she saw Dr. Buttar and
petitioner said yes. Id. at 73-74. She directed petitioner to look at her supplemental declaration,
Ex. 139, page 17, paragraphs 64 and 65, and describe video #409_0326_01. Id. at 74. Petitioner
said she was lying on some kind of examination table and personnel had fed her some baby food.
She had not eaten a solid meal in days and was starving. Shortly afterward, she started feeling

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dizzy, nauseated, and sick. She started vomiting and did vomit before this video began. Stan
Kurtz ran out of the room to get Dr. Buttar. Id. The biggest issue she reported to Dr. Buttar was
eating. Id. at 75. She also had weakness, especially with walking, periods of a few seconds
when she would stop breathing, and speech issues. Id.
        Petitioner thought that doing the race on October 17, 2009 worsened her condition quite a
bit. Id. at 76. Some of the treatments Dr. Buttar gave her were hours and hours of some kind of
IV solution whose contents she does not know. Occasionally, Dr. Buttar put her in the
hyperbaric chamber for a period of time. When she received the IVs, she got stronger. She
could eat without a lot of issues. She could eat a chicken sandwich. Id. She would go into the
hyperbaric chamber after IV hydration and eat, drink, and speak fairly well. Id. at 77. Petitioner
believes her symptoms were better because of the IV hydration. When she borrowed a
hyperbaric chamber for about a year or two years after Dr. Buttar’s treatments and got into the
chamber without previous hydrations, she did not experience anywhere near the same effect as
she did when she was on IVs at Dr. Buttar’s or even at the hospital. Id. She was on IV solutions
for eight hours a day when she was at Dr. Buttar’s. Id. at 78.
        When she left Dr. Buttar’s or he decided to cut back her time on the IVs, she got worse.
Her walking issues and difficulty eating came back. The video on October 21, 2009 showing
petitioner eating a chicken sandwich was when she was still hooked up to an IV. Id. She was
able to eat while on the IV. Id. at 78-79. She was able to walk as well. Id. at 79. This seemed
to be true with hospital IVs, which is why she did not improve at Fairfax Hospital, because they
never put her on any hydration or IVs at all. She had walking problems the entire time she was
there. Id. At this point, the undersigned asked petitioner’s counsel why petitioner needed
immunoglobulin intravenously if just fluid with either saline or glucose was enough to make
petitioner better, and asked her to have Dr. Steinman respond to that question. Id. at 80-81.
         After petitioner left Dr. Buttar’s and he stopped the IVs, she went back to the hotel and
thought that she could eat the same way she had earlier in the day, but found out quickly that she
could not. Id. at 82. All her stomach issues came back. Stan Kurtz call Dr. Buttar to see her
than night. Id. Initially, Stan called to have Dr. Buttar bring more IVs, but Dr. Buttar could not.
Instead he brought some drops to see if he could treat her issue after eating. Id. at 82-83.
Initially, Dr. Buttar put on 10 or 15 drops on her arm because her arms were really weak. Id. at
83. Several minutes later, petitioner noticed her speech slightly improved but then it went back
to being slurred. Dr. Buttar applied more drops again to try to get her speech back. In the video,
petitioner described a burning pain because of the drops but it felt as if the burning was her
muscles tightening and then releasing. At the same time, her speech would come back and then
become kind of slurred. “Back and forth. Whatever the drops were doing was not holding.” Id.
       Petitioner said she had a falling out with Dr. Buttar during a 20/20 interview in
December. Id. at 84. She did not want to do it. She was not feeling well, but Dr. Buttar
reminded her that he had treated her for free. She said she was forced into doing the interview
and Dr. Buttar wanted her to stick “with this ridiculous script about talking about autistic kids,”
and she refused to do that. When 20/20 asked her if she were cured, she told them no, not at all,
and she also said things that they did not put in the final cut. She testified one of the things that

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did not go in the final cut was her statement that she was getting worse. That is when Dr. Buttar
stormed out of the interview room and stopped all her treatments. Id.
        Petitioner returned to Dr. Cintron around October 20, 2009 because she was not getting
better with Dr. Buttar’s treatments and his treatments were starting to get a little bizarre. Id. at
85. She thought it was time to cut ties with Dr. Buttar and find an actual good doctor. Dr.
Cintron prescribed Valium to help her walk. He also referred her to Dr. Tanenbaum, a
cardiologist, because she was having trouble with high heart rate and blood pressure. Id.
Petitioner said that Dr. Cintron believed she had a vaccine reaction causing movement disorder
issues and autonomic issues. Id. at 86. She took a stress test and, when she got close to her
maximum heart rate, she felt really dizzy, lightheaded, and overall not well. She got weak and
collapsed from the lightheadedness. The doctor told her she had some kind of neurocardiogenic
syncope. Id.
        In late October, early November, her voice settled on a speech impediment that sounded
like a foreign accent. Id. at 86-87. It was better in the morning but, by the end of the day, it was
more pronounced. Id. at 87. However, the slurred speech would return when she ate too much.
In February 2010, she had a transcranial Doppler where the technician pushed a wand against
both her carotid arteries. Petitioner was lying down and not feeling well from the procedure.
When the technician finished, petitioner tried to sit up and became so dizzy and lightheaded that
she started almost falling over and felt as if she were going to vomit. The technician called in
Dr. Cintron and he said petitioner had some autonomic issues and he wanted her to go to the
hospital. Id. She saw Dr. Nayak on February 12, 2010 after the stress test with Dr. Tanenbaum
because Dr. Nayak was a specialist in autonomic instability. Id. at 88. Dr. Nayak did an EKG
and checked her heart rate and blood pressure. He touched her carotid arteries and she started
getting lightheaded and dizzy again. Id. Dr. Nayak believed the cause of her problems was the
vaccination and what happened in the beginning might have been some sort of GBS-type of issue
and she should have been on IVIG or plasmapheresis early on. Id. at 88-89. Dr. Nayak said she
should see an electrophysiologist. Id. at 89.
        Petitioner saw Dr. Christine Cosgrave, a psychologist, who told petitioner she had a
neurological issue and should see a neurologist. Id. Petitioner saw Dr. Atiga, whom Dr. Nayak
had recommended, on March 23, 2010. Id. at 89-90. Petitioner had to go running in order to be
able to keep any food down. Id. at 90. She still had dizziness, lightheadedness, and a high heart
rate. Dr. Atiga put her on Norpace to increase her exercise tolerance. Her problem was when
she stopped running, she got so dizzy and lightheaded that it was dangerous to stop exercising.
Id. He also prescribed Midodrine to get her blood pressure higher. Id. at 90-91. Dr. Atiga told
her he believed the vaccination caused her problems. Id. at 91. She started taking Neurontin in
December 2010. She started having trouble with Valium because it made it difficult for her to
breathe at times and made her a little bit weaker. After a couple of days of taking Neurontin, she
did not have any more issues with walking. Id. An increase in the dose in March improved her
walking greatly. Id. at 91-92. She did not have the stuttering in her speech as much on
Neurontin. Id. at 92. Her foreign accent did not improve on Neurontin, but her dizziness and

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lightheadedness slightly improved. Neurontin helped slightly with her voice issues. It helped
mostly with her walking and jerky movement of her neck.
        Inside Edition did an interview outside Walmart as an update in mid-January 2010. Id. It
was early in the morning and she was heading from a fabric store to her car when the interviewer
approached her in the parking lot. Tr. at 93. Her walking was good. She had a little bit of a
walking issue from a slightly torn quadriceps. She had the speech impediment in the video. She
explained she walked sideways in the video to get to her car because it was parked close to
another car. Id. She went to an emergency room the day after the video. Id. at 94. The hospital
put her on a couple of IV hydration saline to help with her fainting and getting lightheaded which
had occurred during the transcranial Doppler when the technician pushed on her arteries. Id.
        Petitioner said she noticed in April or May 2010 that she had issues with walking in
extreme heat, which to her would be 85 degrees. Id. at 96. Her walking would become weak,
she would have trouble speaking (slurring), she would get lightheaded and dizzy, and she would
start having trouble breathing. If she exercised, usually running, she became able to eat more
food or a normal moderate diet without having nausea, vomiting, or lightheadedness, but it was
exhausting to keep doing that. Id. Dr. Atiga told her to keep her meals small and space them
throughout the day. Id. at 97. She found she could eat more calories if she exercised. She
moved to California to get out of the heat in Washington, DC. Id.
        Dr. Atiga did the first tilt-table test on petitioner on July 15, 2010. Id. at 98. Petitioner
said a few minutes into the test, she started having trouble speaking and her speech became
slurred. Then the technician gave her a spray in her mouth and, quickly afterward, her speech
became even worse and she had a brief period of trouble breathing. She shook and got dizzy.
That is when the technician completed the test. Petitioner said she had slurred speech for close
to an hour afterwards. The technician would not let her go until her speech improved. Id.
        Dr. Atiga thought petitioner might have a problem with blood flow in her brain and she
looked up top doctors specializing in autonomic issues, making an appointment with Dr. Yan-Go
at UCLA. Id. at 98-99. Petitioner said Dr. Yan-Go thought she was having some autonomic
issues and did her own assessment, recommending petitioner see a gastroenterologist about her
eating problems and have an esophageal test for motility for swallowing issues. The motility test
showed that her swallowing was normal. Id.
        Petitioner saw Dr. Ghassemi, a gastroenterologist, at UCLA in August 2010. Id. at 100.
Petitioner testified that Dr. Ghassemi thought her issues were autonomic and within the
neurologic specialty. He recommended Sandostatin, whose generic name is octreotide, an
injection one self-administers before meals. Id. She obtained the medication and it worked
perfectly. Id. at 101.
        She found an autonomic lab in Ohio to get a second tilt-table test as Dr. Yan-Go had
recommended. Id. at 102. She had a lot of the same issues with the second tilt-table test as at the
first one, but not as severe. She noticed she had a high heart rate, her hands and feet were
freezing, and she had a little slurred speech. Id. Dr. Atiga called her and told her she had POTS,
grade two. Id. at 103. She had testing to get documentation that she needed Sandostatin which

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consisted of blood pressure measurements at intervals while she ate. Petitioner believes there
was an 18-point drop in blood pressure. Id. Petitioner said that Dr. Wilkinson, her cardiologist
in Seattle, believed her blood pressure, heart rate, dizziness, trouble eating, speech impediment,
i.e., the whole condition, was due to the vaccination. Id. at 105.
        On July 29, 2011, petitioner saw Dr. Grubb at the University of Toledo, who is supposed
to be the top specialist in autonomic issues and POTS. She waited almost a year to see him. Id.
Dr. Grubb had a frank discussion with her that none of her symptoms was treatable by
medication and that her life would not return to the way it was before. Id. at 106. He told her he
was not surprised by her divorce because a lot of spouses leave after someone becomes ill. He
also said petitioner would probably never be able to have children because pregnancy would be
too difficult and dangerous, and she would not have the physical capability to take care of
children if she were able to have them. She thinks they spoke for almost two hours. Id.
Petitioner said that Dr. Grubb told her the vaccine caused this and he had seen similar cases in
the past. Id. at 107. Dr. Grubb told her that the vaccine caused some kind of autoimmune
response that attacked her nerves controlling her autonomic system. He drew pictures for her.
He prescribed Mestinon to help the autonomic issues and a vitamin to see if it would help her
cognitive issues. Id. Dr. Grubb told her that Mestinon was used for myasthenia gravis, but off
label, for autonomic issues. Id. at 108.
       Petitioner said she tried Mestinon for a day or two and did not notice that it affected her
autonomic issues although her speech was a little better. But since it was expensive and not
improving her autonomic issues, she stopped taking it. She could not afford to spend money on
a medication that did not improve her symptoms dramatically as she had hoped. Id.
        Petitioner’s general practitioner ordered a SPECT scan to see if it would identify the
cause of her issues with dizziness and cognition. Id. at 108-09. The result was that she had
issues with blood flow in her brain and doctors needed to rule out lupus and a second
autoimmune disease. Id. Her gastroenterologist Dr. Elmer Chang recommended petitioner
continue Sandostatin but, after a year or 18 months, the Sandostatin stopped working. Then Dr.
Chang recommended a feeding tube. Eventually her feeding issues became impossible to
manage. Id. She was vomiting and could not keep food down. Id. at 110. In 2013, she had a
feeding tube inserted. Earlier, a gastric emptying study showed severe gastroparesis which Dr.
Chang said meant food was not moving out of her stomach as fast as it should and that is why
she was vomiting. Id.
        In 2012, petitioner had another ANA panel and the result was higher than her first ANA
panel, the first being 1:40 and the second being 1:320. Id. at 114-15. In January 2012, she saw
Dr. Lyden, a neurologist, at Cedars-Sinai. Id. at 115. He said petitioner had nystagmus. Id. Dr.
Leyden said her reflexes were not present. Id. at 116. He also said her pupil size was irregular.
Id. Petitioner provided him with all her medical records. When she saw Dr. Lyden a couple of
days later, he had completely changed in his tone toward her. Id. He no longer wanted to see
her and dismissed all of his earlier findings. Id. at 118. Dr. Lyden said petitioner needed to see a
psychologist. His demeanor completely changed. Petitioner stated Dr. Lyden must have seen

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something in the medical records about the media. He had not seen her medical records before
her first visit to him, but only after that first visit and before the second visit. Id.
        Then petitioner saw Dr. Olek, a neurologist specializing in MS. Id. at 119. Petitioner
said she had been stable for two and one-half years, but starting in January 2012, she was much
worse. Her fingers turned completely white anytime she was near cold. She could not eat very
well, despite being on $5,000 a month medication. She had a dropped foot. She saw Dr. Olek in
February 2012. He thought she might have autoimmune dysautonomia or autoimmune
autonomic issues. He thought she might have central nervous system lupus. Id. She was in
extreme pain from her stomach extending out so far she looked pregnant. Id.
        Petitioner went to see Dr. Gee, a neurologist. Id. at 120. He was thinking she might have
autonomic issues and wanted to test for lupus. Id. at 121. He told her the vaccine caused her
issues. Id. She saw the rheumatologist Dr. Wallace in spring 2012. Id. Petitioner testified that
Dr. Wallace thought she had an autoimmune autonomic disease and that she might have
myasthenia gravis. Id. at 122. Petitioner stated that when she worsened in 2012, she thought she
would try Mestinon again that Dr. Grubb had prescribed and found it improved all of her muscle
issues. She no longer had problems with walking, strength, breathing, or speech. Id.
        In November 2013, petitioner went to the hospital emergency department because she
was very weak and had a cold plus a fight between her cat and her dogs produced stress. She
had stridor. Id. Her perception of stridor is that her vocal chords were collapsing and not
allowing air to come in. Id. at 123. She noticed every time she became ill, her foreign accent
came back and she would have breathing issues at night and walking issues. Her muscle
weakness became worse. The hospital ED noticed her heart rate was extremely high and that she
had a heart arrhythmia called a long QT. Id.
        Dr. Hung, a cardiologist, told her that a long QT is extremely dangerous and can be
quickly fatal. Id. at 124. The doctors suspected autoimmune autonomic disease was perhaps
exacerbating arrhythmia in her heart. Id. Dr. Gee told her his sister died of lupus in her twenties
and that the progression of petitioner’s disease was very severe and affecting a lot of critical
systems. Id. at 124-25. He said petitioner should fight as long as she could and see if IVIG
would extend her life. Id. at 125. Petitioner testified that Dr. Gee tested for myasthenia gravis,
but she was either on steroids or IVIG and he gave up trying to get lab results. Dr. Gee said
petitioner had myasthenia gravis because she responded to Mestinon and to IVIG. Id.
        Petitioner went on IVIG every four weeks after this hospital visit and it improved her
muscle weakness and stomach slightly. Id. at 127-28. But her breathing and muscle weakness
were not fully under control and she still had dizziness, fainting, and problems with heat and
breathing. Id. at 128. Because her symptoms on IVIG were not fully resolved, she saw Dr.
Sheean in San Diego. Id. Dr. Sheean said the vaccination caused petitioner’s rhabdomyolysis
that led to her myasthenia which led to her autoimmune autonomic neuropathy. Id. at 130. Dr.
Sheean said, in the alternative, the vaccine triggered all three at the same time. He thought
petitioner’s IVIG dosage was too low and should be raised “to mop up the antibodies” her body
was making every month. Id. He also said her contraceptive pills were making her diseases

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worse and she needed to avoid getting pregnant. Id. at 130-31. This is what led petitioner to
have a hysterectomy. Id. at 131. Dr. Sheean wanted petitioner to take a low-dose of a
chemotherapy drug. He said all the IVIG was doing every month was “just mopping up the mess
of the antibodies” and he wanted her to take the chemotherapy drug “to kind of stop the immune
system completely.” Id. She did not want to go on the chemotherapy drug until she figured out
whether to donate her eggs to her cousin or what options she had. Id.
        Petitioner is still on IVIG. Id. at 132. Her muscles weakness is improved. She had
occasional breathing issues in the middle of the night while sleeping. However, the new dosage
of IVIG is so high that she has more problems eating and relies more heavily on the feeding tube
to get through the several hours between breakfast and dinner. Id. She still has dizziness on the
new dosage. Id. Dr. Gee said that high-dosage IVIG worsens autonomic problems. Id. at 133.
Petitioner does not know if she still has rhabdomyolysis. Id. Petitioner stated she does not see a
doctor separately for autonomic dysautonomia. Id. at 135. Dr. Sheean treats her myasthenia
gravis and Dr. Gee treats her myasthenia gravis and autonomic dysautonomia. The IVIG would
be helping her dysautonomia if it were given at a lower dose. Id.
       Dr. Gee said petitioner would be on this treatment for the rest of her life unless she tried
the chemotherapy. Id. at 136. Even though she had a hysterectomy, she still has her ovaries and
she has not decided what to do with her eggs. Id.
         On cross-examination, petitioner admitted that she created a calendar of September to
November 2009 a week before the hearing. Id. at 140. She put it together from memory. Id.
Her testimony about her conversations with her doctors that was not contained in any of her
medical records is all based on petitioner’s memory. Id. at 141. Respondent’s counsel had the
calendar marked as Exhibit SSS, and a seven-page document entitled “Medical Treatment:
Doctor and Personal Statements and Frustrations” marked as Exhibit TTT. Id. at 142. Petitioner
testified she thought her then-husband created Exhibit TTT. Id. at 143. Petitioner found it a
couple of weeks before the hearing. Id. It is written from her then-husband’s perspective. She
thought her then-brother-in-law might have put some of Exhibit TTT together as well. Id.
Respondent moved into evidence a series of reflections on respondent’s expert Dr. Lancaster’s
opinion about the videos as Exhibit VVV. Id. at 152.
         Petitioner thinks she filed 40 hours of videos, half with Dr. Buttar and half taken before
she saw Dr. Buttar. Id. at 165-66. She first talked to Stan Kurtz in mid-October 2009. Id. at
166. It was soon after NBC and Fox News aired on October 15, 2009. Some of the videos
showed petitioner before she arrived at Dr. Buttar’s office. Id. Stan Kurtz arrived at her home
the day before the 8K race petitioner did on October 17, 2009. Id. at 166-67. When Stan Kurtz
arrived, he came with a doctor and a video crew. Id. at 167. Stan Kurtz said in exchange for the
video footage, he would pay for her treatments with Dr. Buttar who he said was making progress
in treating vaccine injuries. Id. At some point, Stan Kurtz put petitioner in contact with Jenny
McCarthy and petitioner did a video chat with Jenny McCarthy. Id. at 168. Stan Kurtz
videotaped petitioner at the beginning and end of the 8K race. Id.

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        Petitioner said her cognitive issues began with recollection, mathematics, and reading.
Id. But most of those problems improved greatly since she has been on IVIG. Id. at 169. She
said her cognitive issues made it harder for her to access information and relay it to people in a
timely fashion. She believes it was Dr. Cintron who diagnosed her with dystonia. Id. She told
him that the physical therapist mentioned dystonia. Id. at 170.
        Petitioner denied a number of details in a history she stated her then-husband gave to
Inova Fairfax and Loudon hospitals and (with her then-brother-in-law) to Dr. Buttar, including:
fainting, chest pain, uncontrollable laughing, trembling, hot flashes, drinking a glass of wine and
two mixed drinks over a four-hour period, constant sweating, sore throat, the correct date of the
vaccination, greenish-yellow mucus, taking a decongestant and two Aleves, body aches most
severely at spots injured while working out (hip, muscle, bicep pull), blacking out. Id. at 171-81.
Petitioner said she had trouble speaking at the time and her then-husband did all the talking to
the doctors. Id. at 181.
         Petitioner denied the accuracy of Dr. Mannon’s notes on September 27, 2009 when he
wrote petitioner’s speech was quite clear. Id. at 188. Petitioner insisted she had speech and
stuttering issues. Id. She said the psychologist recognized she had to whisper because she had
trouble talking. Id. Petitioner stated Dr. Mannon got a history from her then-husband because of
her problem talking either because she was stuttering or slurring. Id. at 189. She said, “In my
opinion, there was no clear speech. It was not clear.” Id. Petitioner denied she had had a flu-
like illness. Id. at 190. She said she had had symptoms she never had before. Id.
        Petitioner said that her then-husband filled out the VAERS report even though her name
is on the completion line. Id. at 191. When petitioner heard that the VAERS report identified
“parent” as the identity of the relationship to the patient, she thought her former father-in-law
might have filled it out. Id. at 192. Or maybe both her then-husband and his father filled out the
VAERS report. She believes that because the wrong date of vaccination is on the form. Id.
Petitioner denied that she had written she had a sore throat, nasal congestion followed by fever,
body aches, chills, and a headache. Id. at 193. She denied having a sore throat, nasal
congestion, a headache, or a fever. She guesses her former father-in-law filled out the VAERS
form. Id. Petitioner denied even knowing what VAERS was. Id. at 194.
        Petitioner denied writing in the VAERS form that she had flu-like symptoms, fainting,
violent convulsions, walking as if she had MS, and entire body shaking. Id. She said her former
father-in-law was an English major and he does not write anything in the third person if it is
supposed to be in the first person, which is why the language in the form sounds as if she had
written it, i.e., “my,” and “I”. Petitioner said the symptoms in the VAERS form are not
consistent with what her actual symptoms were at the time (the form is dated October 7, 2009)
and given her former father-in-law’s “anal retentiveness to English being proper, I believe that
he filled this out and put it into the first person, especially since a lot of these symptoms are not
what I remember and reported, the vaccine date is wrong, and he has parent as relationship to the
patient in here.” Id.

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        Petitioner said she did not recall having a sore throat or congestion. Id. at 196. She does
remember allergies. She said that all the histories given to doctors and hospitals that, after the
flu vaccination, she had a cold, a cough, a sore throat, a fever, and mucus are wrong. Her then-
husband gave those histories because she had trouble breathing and speaking and she relied on
him to be the communicator. She did not have the capacity to speak up and correct him. Tr. at
195-96.
         Respondent’s counsel asked petitioner if she were too ill on October 7, 2009, the date of
the VAERS form, she was also too ill to do anything on the computer. Id. at 197. Petitioner
replied that she could work minimally on the computer, but she had trouble eye tracking and
trouble reading. She said she was more focused on trying to eat and alleviate her symptoms
which was why her then-father-in-law and then-brother-in-law were there, to help with
administrative things. She could check e-mail but not transcribe a whole report. She could look
at things in the morning. Id. Petitioner said she discovered a way to read by using a piece of
paper to track a computer page. Id. at 198. She would put the piece of paper on the screen. But
this was so exhausting and time-consuming that she could not read all the e-mails she used to
read at work. She was just able to do enough to see if her mother e-mailed her, but not enough to
fill out an entire VAERS form and that is why her former father-in-law and former brother-in-
law were in town. Id. She does not remember if she used the piece of paper on the computer in
early or late October or early November. Id. at 199.
        Regarding putting on her makeup, petitioner said she would have a short period of time in
the morning when she did not have any symptoms. Id. And when the period of 30 minutes
ended, she would have difficulty walking. She told doctors she had uncontrollable tremors. Id.
Originally, she had an hour in the morning before her symptoms would “kick in.” Id. at 200.
Then that time period shortened to about 30 minutes, then 20 minutes, and so forth. In the
morning, during that period, she would do what she did as if she were going to work: take a
shower, get ready, and put on makeup. Then she would eat breakfast. That is when she started
having tremors and walking problems. After that period, she would have speaking issues after
she ate. Id. Petitioner said her tremors were limited to her neck and hands. She does not recall
if her entire body had tremors. Id.
        In the morning, she was able to lift her hands to her face to apply her makeup, including
mascara and foundation. Id. at 201. She washed her hair every three to four days. Id. She also
applied eyeliner, but she had to sit down and use her elbow resting on the table to apply the
mascara, eyeliner, and eyeshadow. Id. at 202. Petitioner had a vanity and put her elbow against
the vanity to apply her makeup. Id. She did not need to hold the opposite eye taut while she
applied the eyeliner and mascara because she “was really good at it.” Id. at 203. She used liquid
eyeliner and found a trick for applying mascara where if she just held the brush and blinked into
it, she would apply the mascara. Her eyebrows are so thick, she did not need eyebrow pencil.
Id.
        Petitioner said that she usually sat down in the shower even before she became ill. Id. at
204. It was just easier for her. She would lean her elbows against her knees and turn her head
down to reach the shampoo and minimize the muscle strength to wash her hair. She still uses

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those techniques. Id. She would air dry her hair. Id. at 205. She had a hair dryer attached to the
wall like a hand dryer in a gym, but this was an ionizer. The only thing she found difficult was
brushing her hair when it was wet. Id. That was to get all the knots out. Id. at 206. She put her
elbow on the vanity and tried to use both hands to get out the knots or would ask her then-
husband to help. She still uses these techniques today. Id.
        Petitioner said her then-husband did not want her to drive. But once she got stronger
with the medication Dr. Cintron prescribed, she would go out when her then-husband was at
work. As seen in Inside Edition, she went shopping at a fabric store and her then-husband did
not know she was out. She told the interviewer of Inside Edition not to let her then-husband see
the interview. She had “ways of dealing with the weakness, just clever.” Id.
        Petitioner said that September 12, 2009 was when she had a lot of weakness because it
took longer than usual for her to get ready to go out to breakfast with her then-husband. Id. at
207. She clarified that when she said she sat in the shower, it was not on a chair but on the floor
of the shower and she would use the handles of the stall shower to lower herself and raise
herself. Id. Petitioner said September 23, 2009 was when she started having walking issues. Id.
at 208. The handles in the shower were an inch or two inches above her head when she sat on
the floor of the shower. Id. at 209. The shampoo was located on the floor of the shower and
petitioner used body wash instead of soap. The body wash was on the floor of the shower, too.
Id.
        Petitioner testified her symptoms were at their worst when she went to Dr. Buttar’s clinic
in October 2009. Id. at 210. She rapidly deteriorated after her 8K race on October 10, 2009.
When she arrived at Dr. Buttar’s clinic, she was too weak to walk. After she ate, she would have
tremors. Id. Petitioner had tremors associated with eating or drinking, usually in the mid-
morning and afterward. Id. at 210-11. She described her tremors as a shaking of her neck and
sometimes her arms. Id. at 211. “It was kind of like a weakness that wasn’t – like a weakness in
the muscles that was making it tremor is kind of how I felt.” Id. At the time, she and her then-
husband referred to them as seizures even though they did not know what they were. But in
retrospect, they were definitely more like tremors and “not seizures.” Id. Petitioner thinks her
then-husband was reporting them as seizures and saying they happened 60 times a day because
petitioner was not able to count how often they happened. Id. at 211-12. “We were counting
something that we thought were seizures when they were really just tremors.” Id. at 212.
        When she reported seizures to doctors, she meant tremors. Id. Petitioner thinks the
tremors in early or mid-September 2009 were not as significant as they were closer to her
visiting Dr. Buttar’s clinic. Id. at 213. The tremors worsened quite significantly after she ran the
8K race. Id. If she tried not to move and tried not to eat or drink, she did not have any tremors.
Id. at 214. They were just little bursts of weakness. In early September, she ate only twice a
day. Id. She did not have an appetite. Id. at 214-15. Later in September and in October, she
was concentrating on keeping food down. Id. at 215. It did not matter what kind of food she ate.
She would be more likely to have a longer period of tremors toward the end of the day than
earlier and she would have more nausea and vomiting at that time of day. Id.

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         In October 2009, she had five or ten minutes after she ate before getting lightheaded and
dizzy, and if she did not lie down, “the tremors would come on.” Id. at 216. After that period,
she would get tremors or weakness in her arms and neck if she put anything in her mouth and
tried to chew or swallow. If she did not move, she was fine. But the moment she tried to eat
more or use those muscles again, the tremors would return. Id. At some point, she had to eat all
her meals lying down. Id. at 217. Some of the videos show her lying down and eating. But
moving her tongue around to swallow what she chewed would cause tremors and issues with
muscle weakness. She thinks being wheeled backward after looking at the carpet in Dr. Buttar’s
office started making her feel sick and the tremors “started to happen.” Id.
         Petitioner said while she was at Dr. Buttar’s clinic, she was not allowed to speak. Id. at
218. All they allowed her to do was make gestures. They did not want her speaking because
they thought speaking would worsen her symptoms. She agreed that the videos in Dr. Buttar’s
office in mid-October 2009 showed her having a lot of tremors. The tremors started when she
tried to shake Dr. Buttar’s hand or when they fed her baby food and she immediately got sick
and lightheaded and started having tremors. Id. Any sort of muscle movement would cause
tremors which she attributes to a weakness in her arms and neck. Id. at 219. Petitioner thinks
the weakness caused the tremors. Id. at 220. Drinking cold liquids would cause the tremors. Id.
        Respondent’s counsel asked petitioner if the Inside Edition news broadcast that aired on
October 16, 2009, Ex. GGG, was a good example of her forward-walking gait problem. Id. at
221. Petitioner agreed that that is what her gait looked like before going to Dr. Buttar’s office.
Id. at 222. It was after she was discharged from Johns Hopkins Hospital on October 5, 2009 and
before she saw Dr. Cintron October 15, 2009. Id. at 223-24. Her weakness began on September
23, 2009, but the jerky gait did not begin until closer to her going to Johns Hopkins. Id. at 224.
When she went to Johns Hopkins, she had the same gait as the Inside Edition broadcast showed.
Id. at 225. Her gait and speech problems completely resolved when she ran. She also found that
she could walk normally sideways. Id. She recalled that one of the sensory tricks that worked
was touching her hand to a pressure point on her leg and, if she tied a belt to her leg, she was
able to walk forward mostly normally. Id. at 226.
        On October 2, 2009, petitioner had a lot of difficulty talking without stuttering when she
went to Johns Hopkins. Id. at 227. Although the notes at the hospital said she could be
understood quite well if she were singing, petitioner does not remember that. Id. She said only
Dr. Cintron asked her to sing for him and that was well after she went to Johns Hopkins. Id. She
does recall that she could speak well while whispering at Johns Hopkins. Id. at 227-28. She
learned that whispering enabled her to talk normally at Inova Fairfax Hospital September 26,
2009. Id. at 228. She said she did not correct the wrong information her then-husband gave to
the doctors at Inova Fairfax because they did not come to see her after she was admitted as a
patient and she was limited to the nurses. Id. at 229. It was still cumbersome to try to whisper to
someone an entire history especially the doctor who interviewed her. Id. at 229-30. Whispering
relieved her stuttering. Id. at 232.
       Petitioner arrived at Dr. Buttar’s office on October 19, 2009. Id. at 234. Her symptoms
were at their worst. Id. at 235. She does not know why Dr. Buttar did not take her to the

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hospital. Dr. Buttar immediately hooked petitioner to an IV and put her feet in a foot bath that
he said would help chelate her. Id. On October 20, 2009, the day after she arrived at Dr.
Buttar’s clinic, petitioner had a remarkable improvement in her symptoms. Id. at 236.
Following the IVs, she got much better. She was able to communicate with an entirely normal
voice. After the rounds of IVs and maybe the chelation, she was able to speak and walk pretty
well. She told Dr. Buttar she felt the best she had felt in the prior month. She told him she was
starving and requested chicken. Dr. Buttar told her that her improvement would likely be
transient and she would need more treatment. Id. On October 20, 2009, she was able to walk
out of Dr. Buttar’s office and return to her hotel room. Id. at 236-37. She could walk and talk
normally. Id. at 237.
       When she returned to her hotel room and ate, she had a recurrence of her symptoms. Id.
Stan Kurtz called Dr. Buttar. Id. at 238. She was lying down on the couch and had slurred
speech and muscle weakness in her arms. Id. Dr. Buttar came and put liquid TD (“transdermal”)
DMPS on her arms. Id. at 238-39. Ten minutes later, after Dr. Buttar repeated the drops on her
arms, her speech returned and then went back to slurring. Id. at 239. Briefly, her speaking
improved. She said she had a burning sensation moving throughout her body. Id. Her muscles
were spasming, tightening, and constricting, going from her lungs to her neck or throat and face
and then it dissipated. Id. at 239-40. After the burning, she had difficulty speaking again. Id. at
240. Dr. Buttar put more drops on petitioner and the speech eventually completely resolved, but
she never got up and does not know if the weakness, dizziness, and nausea improved. Id.
       Eventually, petitioner did get up after the food had moved out of her stomach in an hour
or an hour and one-half. Id. at 241. She used the drops one or twice afterward and believes they
resolved some of the muscle weakness or the tremors. Id. at 242.
        There is a video of petitioner in the hyperbaric oxygen therapy chamber with Stan Kurtz
talking to her, saying this was the first time he had heard her voice. Id. at 243. Dr. Buttar’s IVs
allowed her to speak. Id. She does not know why Stan Kurtz said this was the first time he had
heard her voice. Id. at 246. There were periods of time when her symptoms improved before
she went in the hyperbaric oxygen therapy chamber. Id. at 248.
        In mid-September 2009, she had cognitive issues where she could not do math or process
conversations. Id. She noticed it more toward the end of her visit to Dr. Buttar’s clinic when she
no longer had to worry about walking or talking. Id. Her cognitive skills improved slightly in
late December 2009 or early January 2010 when she had occupational therapy. Id. at 249. The
most dramatic of the cognitive improvement came with IVIG. She thinks that when her speech
issues resolved, she was left with a speech impediment which sounded like a foreign accent. Id.
On November 6, 2009, her stuttering and inability to talk resolved, but she could not move her
tongue properly and her speech sounded like an accent. Id. at 250.
       On the second day of testimony, on redirect, petitioner said that Dr. Buttar would start her
treatment on a few hours of IV before she ever went into the hyperbaric oxygen therapy
chamber. Id. at 264. They did not give petitioner oxygen in the hyperbaric chamber. Tr. at 265.
She was inside the chamber for an hour. Petitioner found it hard to say whether there was any

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difference being in the chamber. She always felt better after Dr. Buttar gave her several hours of
IVs. Id. He said she could eat and drink in the hyperbaric chamber. Id. She noticed that her
mercury levels were barely out of the normal range and she does not know what mercury was
coming out of her system. Id. at 267.
       On recross, petitioner stated that she believed at the time that when Dr. Buttar gave her
the IVs, she started to feel better. Id. at 268.
                                   Dr. Steinman’s Testimony
        Dr. Lawrence Steinman testified next for petitioner. Id. at 271. He is board certified in
neurology. Id. at 272. He stressed that he is not an advocate. Id. at 273. He said even though
he appears only for petitioners in the Vaccine Program, he does not appear when a case does not
have merit. Id. He is a specialist in multiple sclerosis and does animal experimentation. Id. at
278. At the time of the hearing, Dr. Steinman was treating patients no more than 25 percent of
the time. Id. at 281. He does full-time practice for two to four weeks a year as he is then in
charge of the neurology ward, but because of his other activities, he stopped doing outpatient
work when he became chairman of the department of immunology. In his earlier years, he split
his activities between clinical and research 50-50. At the time of the hearing, he was doing
research 75 percent of the time. Id. He said everything he does involves teaching and learning.
Id. at 282.
       For the first 35 years of his career, the National Institutes of Health has been the main
source of his funding at Stanford. Id. He was elected to the National Academy of Medicine and
the National Academy of Sciences. Id. at 283. In 2011, he received a lifetime achievement
award from the International Federation of MS Societies named after Martin Charcot, who
discovered or first described MS. Id. at 284-85. Sigmund Freud was one of Charcot’s students
and the two of them are responsible for what then was called hysteria but is now termed
conversion disorder. Id. at 285.
       Dr. Steinman said he talks a lot about molecular mimicry in this case, but he does not
have a known molecular mimic that he can identify:
               THE WITNESS: I talk a lot about molecular mimicry, and I don’t
               have a known molecular mimic that I can identify. There might be
               one, but I haven’t been able to identify it, including something in
               the influenza vaccine that Petitioner received . . . .
Id. at 286. He thinks there might be one, but he has not been able to identify it. Maybe it would
be on an autonomic acetylcholine receptor in a ganglion. Dr. Steinman testified that the
autonomic nervous system is myelinated and a reaction to myelin can cause dysautonomia. Id.
He stated there is a spectrum in inflammatory neuropathies between GBS to inflammatory
demyelinating neuropathy and dysautonomia. Id. at 287. He thinks a common mechanism can
link the pathogenesis. He thinks that if the autonomic nervous system is myelinated and there is
damage to autonomic myelin, that can also damage the underlying axon and underlying nerves to
cause dysautonomia. Id.

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         The undersigned asked if dysautonomia can occur without damage to the myelin of the
autonomic nervous system. Dr. Steinman said it probably can be an immune response against
the ganglionic acetylcholine receptor. Id. Petitioner in this case was not tested for it. Id. at 288.
If petitioner had been tested for an immune response against the ganglionic acetylcholine
receptor, the antibody is positive only about 50 percent of the time. Id.
        The undersigned asked if myasthenia gravis is a dysautonomic disease. Dr. Steinman
replied myasthenia gravis is a disease against the acetylcholine receptor at the neuromuscular
junction. Someone with many of the symptoms petitioner described can have myasthenia gravis.
Dr. Steinman said there are a few other antigenic targets, e.g., muscle-specific kinase, but he
does not know that any of these other antigenic targets is a direct molecular mimic of anything in
influenza that cross-reacts with myelin. Id. He thinks that when someone has both
dysautonomia and myasthenia gravis, a connecting mechanism probably exists. Id. at 289.
        Dr. Steinman said he has done a lot of research on myasthenia gravis and published on it.
Id. at 290. He stated myasthenia gravis is probably one of the best understood of all autoimmune
conditions. Some interesting molecular mimics between other viruses, but not influenza virus,
exist. He cited as an example herpes virus and acetylcholine receptor as a molecular mimic. Id.
       Dr. Steinman said that, as a practicing neurologist over the years, he has seen people with
dystonia. Id. It is a whole specialty unto itself. Id. at 291. He has seen a whole catalog of
abnormal movements. He testified he has been involved in diagnosing dysautonomia. He is the
general attending physician on the neurology practice and often gets patients with dysautonomia.
The neurology practice sees dysautonomia occurring when a patient has the inflammatory
neuropathy GBS. The neurology practice also sees dysautonomia associated with other
neurologic diseases. Sometimes, the neurology practice sees people presenting primarily with
dysautonomia. To Dr. Steinman, dysautonomia is one of the less well understood areas of
neurology. Id.
        Dr. Steinman said he has dealt with diagnosing people with POTS. In POTS, the patient
has difficulty regulating postural changes, i.e., getting up from a supine position, and the
patient’s heart will race. Id. Dr. Steinman called the condition “fascinating.” Id. at 292.
        Dr. Steinman stated he has seen and treated many patients with myasthenia gravis.
Nearly all his patients with myasthenia gravis have had altered speech with stridor and a voice
that gets weaker during the day with nasal speaking. He has also seen patients with MS,
especially those with impairment of their cerebellar pathways who have speech that is very hard
to understand.
      He refers patients with gastroparesis to a gastroenterologist although he has seen patients
who have gastroparesis as a manifestation of dysautonomia. Id.
       Dr. Steinman interprets someone speaking with a British or Australian accent as really
having nasal speech. Id. He said one can hear foreign accent in people who have dysphonia
from dystonia. Id. The undersigned asked if when people have a cold, they sound like Laurence

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Olivier, to which Dr. Steinman responded that he was nodding his head in agreement and he does
not have full answers, but it is intriguing. Id. at 294.
        Dr. Steinman’s opinion is that 10 days after receiving flu vaccine, petitioner had
symptoms of rhabdomyolysis followed by a series of neurological symptoms that he would
describe as ultimately dysautonomia. Id. at 295. His opinion is that flu vaccine was the trigger
of both the rhabdomyolysis and the dysautonomia. He does not link the rhabdomyolysis to the
dysautonomia, but he thinks flu vaccine triggered both. Id. When the undersigned asked Dr.
Steinman if he thought petitioner had myasthenia gravis and that the flu vaccine caused it, Dr.
Steinman responded that he thinks dysautonomia caused petitioner’s major problem and very
fine doctors think she has myasthenia gravis and he agrees with them. Id. at 295-96. He said
petitioner has been on treatments for myasthenia gravis. Id. at 296.
        Dr. Steinman testified that petitioner’s case is one of the most complicated because of
several different diagnoses which some superb treating doctors made. Id.
        Dr. Steinman defined autoimmune inflammatory neuropathy as a condition in which the
immune system attacks myelin, predominantly in the peripheral nerve or nerve roots. Id. at 297.
Its most classic manifestation is GBS. One of the manifestations of autoimmune inflammatory
neuropathy is dysautonomia. Dr. Steinman would put at one end of the spectrum inflammatory
neuropathy dysautonomia and at the other end of the spectrum GBS without dysautonomia or
with some dysautonomia. He views that spectrum as the same disease. Id. He stated in
autoimmune dysautonomia, the manifestation of symptoms is related to the autonomic nervous
system, including heat intolerance, cold extremities, excess sweating, feeling too warm,
problems with gastric motility, problems with maintaining blood pressure when getting up from
a chair or from a supine position. Id. at 297-98.
       The undersigned asked Dr. Steinman if all dysautonomia is autoimmune. Id. at 298. He
responded probably not. He said there are likely to be some inborn errors of the autonomic
nervous system that can cause dysautonomia. Id.
       Dr. Steinman then said the following:
               THE WITNESS: And I have to comment, after hearing the
               Petitioner yesterday, even after seeing her on videotapes, and
               certainly after reading the – all the medical records, there is
               nothing like face-to-face meeting with a human describing their
               [sic] problems.
               I spent yesterday, as we all did, hearing the Petitioner, and it’s so
               very different from reading PDFs on a computer and watching
               videotapes on a little screen
Id. at 302, 303.
       Dr. Steinman said petitioner’s onset of symptoms was September 3, 2009 with weakness,
dizziness, and cold-like symptoms. Id. at 304. On September 11, 2009, she had emesis. On

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September 12, 2009, she had decreased appetite, nausea and vomiting. Id. She also had
syncope, shaking because she felt cold, weakness, and talking in one-word answers. Id. at 305.
Dr. Steinman allowed that having cold symptoms may be a symptom of an allergy or an
infection. Id. at 305-06. If Dr. Steinman accepted that petitioner had a cough, sore throat, a
runny nose, and fever, it could be an infection or an allergy. Id. at 306-07. If he were to
consider that petitioner had both an infection and the flu vaccine, he would say the flu vaccine
aggravated the viral infection. Id. at 308-09. He would say the flu vaccine was a substantial
factor. Id. at 309.
        The undersigned said to Dr. Steinman that in order for the vaccine to aggravate her cold,
the cold symptoms would have had to have preceded the vaccination, but here the vaccination
preceded the cold symptoms. Id. at 310. Dr. Steinman agreed that the temporal positioning in
this case was hard for asserting aggravation because how could flu vaccine aggravate the cold
symptoms if the vaccination occurred before the cold symptoms. He then said he felt a lot more
comfortable with saying flu vaccine was a substantial factor. Id. He feels very strongly that
petitioner does not have conversion disorder. Id. at 311.
        Dr. Steinman said that having the flu affects autonomic behavior, from feeling cold,
clammy, and sweaty at the same time as having decreased appetite and feeling sleepy while
feeling faint and sometimes fainting. Id. at 312. Dr. Steinman said that petitioner’s weakness on
September 3, 2009 would certainly be a manifestation of myasthenia gravis. Id. at 313. Talking
in one-word sentences could be a manifestation of myasthenia, which petitioner manifested on
September 12, 2009. The cough could be a manifestation of respiratory weakness, also
myasthenia gravis on September 12, 2009. Fatigue on September 12, 2009 could also manifest
myasthenia gravis which involves feeling tired and weak. Id. On September 17, 2009,
petitioner’s shortness of breath could be due to muscle weakness from myasthenia gravis. Id. at
314. Dr. Steinman added profound bilateral lower extremity weakness followed by minimal
weakness was due to myasthenia gravis. In addition, lower extremity weakness was due to
myasthenia gravis. Id.
        Dr. Steinman explained an elevated ANA is sometimes associated with systemic lupus
erythematosus. Id. Sometimes, it accompanies myasthenia gravis. Id. at 314-15. He admitted
petitioner does not have lupus. Id. at 315.
        In Dr. Steinman’s second supplemental expert report, Ex. 108, he states that autoimmune
inflammatory neuropathy is also known as GBS and GBS is widely known to include autonomic
nervous system symptoms, citing a Medscape article. Id. at 315-16. Dr. Steinman explained that
the autonomic nervous system is myelinated. Id. at 316. He thinks petitioner had a
demyelinating disease restricted to the autonomic nervous system which did not affect the
myelin of her peripheral nerves. Id. at 317. Dr. Steinman believes dysautonomia is a variant of
GBS even without CSF changes and without high levels of autoantibodies that bind to ganglionic
AChR. Id. at 318.
       Dr. Steinman refers to petitioner’s cardiologist Dr. Walter Atiga and his relating the
timing of petitioner’s symptoms of vasovagal or neurocardiogenic mechanism to the date of flu

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vaccination. Id. at 319. Dr. Atiga thought petitioner had an unusual form of neurocardiogenic
syncope because when she did more physical exertion, her symptoms improved and she could
actually eat, but when she did not exercise, she was worse. Id. at 320. Dr. Atiga’s notes that
petitioner had normal heart rate and blood pressure in response to an upright tilt table. But
because petitioner’s symptoms worsened with nitroglycerin, Dr. Atiga thought petitioner might
have a form of cerebral syncope involving dysregulation of cerebral blood flow. Id. Dr.
Steinman thinks the results of petitioner’s tilt-table test was a positive indication that petitioner
had dysautonomia. Id. at 321.
       The undersigned asked Dr. Steinman why petitioner got better on IVs with just saline or
glucose, but not immunoglobulin. Id. at 322. Dr. Steinman said he had “a very elegant
explanation of why she’s feeling better.” Id. He said people with POTS are a little bit
hypovolemic. Id. They do better with an increase in blood volume. Id. at 323.
        While Dr. Steinman was discussing newly-admitted medical articles on the point that
intravenous infusions help people with POTS, petitioner sank to the floor and started growling.
At this point, the undersigned told the court reporter to go off the record. Id. at 329.
       While we were off the record, the undersigned asked Ms. Roquemore if the
undersigned’s law clerk should call 911 and she said yes. The undersigned’s law clerk called
911. All three doctors in the hearing room, including Dr. Steinman, kept their seats. The
undersigned asked Dr. Steinman, since he was petitioner’s expert, to go to her and see how she
was doing. The EMTs arrived and took petitioner away on a gurney to Medstar Georgetown
University Hospital. After that, Dr. Steinman retook his seat as the testifying expert. The
undersigned went back on the record and the following colloquy occurred:
               THE COURT: Dr. Steinman, can you, because you were the one
               administering to her until the EMTs arrived, can you describe what
               was going on?
               THE WITNESS: We noticed that she had developed stridor, very
               noisy breathing. She was actually moving air reasonably well.
               She didn’t look cyanotic from her nail beds, her pulse was fast, but
               regular, and she was having a lot of problems. The EMTs came
               and she wrote down on a piece of paper that normally she would
               take Mestinon, a drug for myasthenia, in this situation.
               I first asked does she need epinephrine, and because of the stridor,
               whether it was pharyngeal edema, and she said no, very
               definitively. And the EMTs are taking her now. They didn’t have
               to put in an IV or intubate her immediately. So, they felt
               comfortable just moving her in a sitting position. …
               THE COURT: Is the attack that you saw that she had something
               that is a part of her illness? Is this myasthenia gravis, is this part of
               dysautonomia, or what is it?

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THE WITNESS: Well, you can certainly see this in myasthenia
gravis, stridor could be part of the dysautonomia, but my first two
guesses were it was either her myasthenia, and she wrote Mestinon
on a piece of paper that she would normally take but she didn’t
have it with her. The second thing that came to mind was she was
having some kind of pharyngeal edema, laryngeal spasm for which
she would want to take epinephrine, but throughout the whole
thing, she moved air. It sounded and looked horrible, but her nail
beds and her lips looked like she was moving air reasonably well.
…
THE COURT: Because conversion disorder has been raised as an
issue, do you think what you just saw and helped her with, trying
to cope with, was an actual episode of stridor, or was this
something that she performed, and it wasn’t actually a physical
problem?
THE WITNESS: It would be pretty hard, in my opinion, to do
stridor. It takes a huge amount of effort for that long as an act. It
really did sound like bona fide stridor, and it was going on for a
long time, but she was moving air. She didn’t turn cyanotic. So,
that’s -- I don’t think it was a manifestation of a conversion
disorder, but I imagine all of these stresses here created a lot of
anxiety, but it looked like – well, it didn’t look like, it was stridor.
If the person can do that as part of the conversion disorder, it’s
pretty impressive.
THE COURT: And you mentioned, and you’ve mentioned it
numerous times, that she was “moving air.” Is that unusual with
stridor? Do you normally not move air with stridor?
THE WITNESS: Well, the biggest concern I had is that she would
turn blue and then we would have to do something – it’s even
really hard to give mouth to mouth with somebody in stridor
because you can’t move them by their vocal cords. So, there’s that
crazy thing that we all hear about, and you would never want a
neurologist to try it, of sticking a pen without the ink cartridge
through their cricothyroid membrane. I mean, I wasn’t going to do
it, I would need a young guy to do that. But in all seriousness, she
did seem to move air okay, in terms of not turning cyanotic.
THE COURT: No, I’m not suggesting that you gave her the
improper treatment, I’m just, because of my own ignorance,
asking, is it unusual to move air if you’re actually having an attack
of stridor?

                                  164
                 THE WITNESS: Most people who have stridor are able to move
                 air okay. I mean, where I’ve seen it really get bad is little kids
                 with croup, you know, they sound like they’re barking, and they
                 start getting cyanotic. She in the sitting up position, which she
                 preferred, was moving air okay.
                 THE COURT: Did she also throw up?
                 THE WITNESS: Just dry heaves.
Tr. at 329-36.
        Dr. Steinman resumed his testimony on direct, going through the medical notes of Dr.
Cintron, petitioner’s neurologist, and Dr. Grubb, her internist and cardiologist. Id. at 341-42.
Dr. Grubb notes autoantibodies against peripheral acetylcholine receptors, but Dr. Steinman said
there is no evidence that petitioner had antiganglionic acetylcholine receptor antibodies. Id. at
342-43. Dr. Steinman’s theory is based on the fact that autonomic ganglia have myelinated
fibers going into them and damage to the myelin could cause a transmission defect. Id. at 343.
Dr. Steinman mentions Dr. Lyden and his initial view that petitioner might have severe
dysautonomia. Id.
         Dr. Steinman said these doctors were giving it their best shot with a lot of difficulty in
putting everything together and that is what he was doing as well. Id. at 344. He said he would
like to know if petitioner had antibodies to acetylcholine receptor before she took IVIG because,
if so, he would not be able to use his theory of molecular mimic to myelin. Id. at 345. He cannot
find a molecular mimic in flu vaccine to acetylcholine receptor. Id.
        Dr. Steinman notes that Johns Hopkins did not diagnose petitioner with GBS. Id. at 347.
Dr. Wallace, a rheumatologist, thought petitioner had Raynaud’s of the brain. Id. at 347-48. The
undersigned asked Dr. Steinman, “You can’t have Raynaud’s of the brain, can you?” to which he
replied, “I don’t think so.” Id. at 348.
        Dr. Steinman said he did not know who Dr. Sheean was before this case and looked him
up. Id. at 349. Dr. Steinman thinks Dr. Sheean’s four possible diagnoses are close to his own
thinking. Id. at 351. Dr. Sheean believes that vaccines can cause myasthenia gravis. Id. at 356.
Dr. Steinman states that the autonomic nervous system, sympathetic and parasympathetic, is
myelinated in its preganglionic portion. Id. at 357. Thus, he says his arguments about how the
immune system attacks myelin after exposure to flu virus leading to autoimmune dystonia are
relevant. The autonomic ganglia received input from demyelinated preganglionic fibers and the
location of this attack disrupted ganglionic transmission. Id. Dr. Steinman repeated that
dysautonomia is a variant of GBS. Id. at 358.
        Dr. Steinman said, regarding rhabdomyolysis, that there are case reports of both flu virus
and flu vaccine causing it. Id. at 359. He said one could make the argument that demyelinated
nerves can innervate skeletal muscle as collateral damage. Id. at 359-60. Dr. Steinman said he
would not invoke the occurrence of rhabdomyolysis in this case in order for him to opine that flu
vaccine caused petitioner’s dysautonomia. Id. at 360. He said petitioner’s case is complex and

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he does not need the “step” of rhabdomyolysis. Petitioner had so many things going wrong, i.e.,
rhabdomyolysis, autonomic neuropathy, some doctors thinking she had myasthenia, not just the
anti-acetylcholine receptor ganglionic response, but also the nicotinic acetylcholine response.
Petitioner was getting hit at all levels. He asked why this was happening in one individual, why
in addition she has ANA antibodies, which may be a predecessor of something like lupus, but we
do not have a full explanation. Dr. Steinman said petitioner is “quite rare.” Id.
         The undersigned told Dr. Steinman that the undersigned did not regard GBS as a
predicate to finding flu vaccine caused petitioner’s dystonia, and the undersigned did not
consider her to have GBS as no one diagnosed her with GBS. Id. at 361. The undersigned
assumed Dr. Steinman was referring to GBS only as an analog. Id. at 362. The undersigned
asked if the undersigned understood his testimony correctly that he was not keying in
dysautonomia to GBS as if it were a Jack and Jill causation. He said, “That’s right.” Id. He said
if there were any relationship, it is at the complete other end of the spectrum. If they were Jack
and Jill, they are only connected by opposite ends of the spectrum. The undersigned asked if that
spectrum were called autoimmunity and Dr. Steinman agreed he would call the spectrum
“autoimmunity.” Id.
         As for petitioner’s having seizures in the videos, even though petitioner denied in her
testimony that she had seizures and said she confused seizures with tremors, Dr. Steinman said
based on the videos, he still does not know if petitioner was having seizures. Id. at 365.
However, he did think the videos showed petitioner had dystonic tremor. Id. at 367-68, 369. He
thought it more unusual for petitioner to lose the tremor when she ran forward. Id. at 368. Dr.
Steinman said he wants to see her in an examining room and put her through various paces and
he cannot have that liberty watching videos. Id. at 371. He said that some of the videos having
to do with publicity created a negative impression in him. Id. He did not like that happening and
this is the part of the case that he is unhappy with. Id. at 371-72. He was not happy that it was
on national news programs and is a medical mystery. Id. at 372. He was unhappy that petitioner
was engaging voluntarily in national publicity. Id.
        Dr. Steinman regards petitioner as having the same dystonia as in the Marsden article
(Ex. 170), in which the subjects could not walk normally but could run, dance, or walk
backward. Id. at 373. He said that stridor can be a manifestation of dystonia. Id. at 374.
Returning to the Marsden article, Dr. Steinman mentioned that Dr. Marsden was the world’s
expert in neuromuscular disease in the second half of the 20th century, and dystonia is a really
puzzling phenomenon. Id. at 375-76. Marsden’s article was on torsion dystonia which is not the
same as dysautonomia, but someone can get dystonia in dysautonomia. Id. at 376. Dystonia is a
subsection of dysautonomia. Id. He said the old term for torsion dystonia was dystonia
musculorum deformans because people thought something was wrong with the muscles. Id. at
376-77. Eventually, the muscles can become hypertrophied and atrophied because of awkward
positions. Id. at 377.
       Stanley Fahn’s article (Ex. 129) describes a clinical variance of idiopathic torsion
dystonia in 1989. The abnormal movements constituting dystonia are diverse with a wide range
in speed, amplitude, rhythmicity, torsion, forcefulness, distribution in the body and relationship

                                               166
to rest or voluntary activities. Id. Fahn mentions a child who has idiopathic dystonia in one leg,
but only when walking forward; it could be absent when running or walking backward. Id. at
378. Dr. Steinman said this is what petitioner had. Id.
        Dr. Steinman stated that many of petitioner’s symptoms overlap with myasthenia gravis.
Id. at 379. He noted that Fluzone, the flu vaccine petitioner received, has been associated with a
case of myasthenia gravis. Myasthenia gravis is associated with dysautonomia. Id. Shukla (Exs.
102 and 103) assessed autonomic function in patients with myasthenia. Id. On orthostatic tests,
myasthenia patients and the control group both had a rise in heart rate, and systolic and diastolic
blood pressure. Id. at 379-80. However, the myasthenia patients had a significantly higher rate
and duration of the rise than the control group did. Id. at 380. Similar differences were observed
in the hand grip test. No difference was observed between the two groups on the
parasympathetic test. The authors concluded that myasthenia gravis patients have sympathetic
hyperreactivity which could cause some hemodynamic abnormalities. Id. Dr. Steinman said that
dysautonomia and autoimmune dysautonomia can affect in some cases parasympathetic fibers.
Id. The most famous parasympathetic innervation159 is the vagus nerve.160 Id. at 381.
         Dr. Steinman testified that there is evidence of dysautonomia from the tilt-table tests and
the QT interval abnormalities, i.e., cardiac arrhythmia. Id. at 382. In addition, the gastric
motility study showed gastroparesis. Id. at 383. Petitioner did not have decremental repetitive
stimulation as electrophysiologic evidence of myasthenia. She did not have acetylcholine
receptor antibodies. Nevertheless, Dr. Sheean thought she could have myasthenia and he is a
pretty compelling person because of his neuromuscular specialty. IVIG treatment could give a
false positive on tests for myasthenia and could also suppress the immune response so that the
tests were negative. Id. He said that IVIG is a popular drug because it is effective in a number
of diseases ranging from GBS to other autoimmune conditions. Id. at 388. It is also approved to
treat inflammatory neuropathy and chronic inflammatory neuropathy to a certain extent. Its side
effects are headaches. Id.
       The undersigned asked Dr. Steinman if petitioner improved because she was able to enter
the courtroom walking forward and did not have any tremors because the IVIG treatment was
working. Id. at 389. Dr. Steinman said it is possible. Id. at 390. The undersigned asked Dr.
Steinman why he hesitated. He responded that he did not know enough about the whole
contemporary picture to know whether to attribute petitioner’s doing better to the IVIG. He
thought petitioner gave a compelling history in the first day of hearing. Her voice was strong
and she held up for a long time on the stand. He thought she was doing marvelously, but then

159
    Innervation is “1. the distribution or supply of nerves to a part. 2. the supply of nervous energy or of nerve
stimulus sent to a part.” Dorland’s at 942.
160
    The nervus vagus is the “vagus nerve: tenth cranial nerve; origin, by numerous rootlets from lateral side of
medulla oblongata in the groove between the olive and the inferior cerebellar peduncle; branches, superior and
recurrent laryngeal nerves, meningeal, auricular, pharyngeal, cardiac, bronchial, gastric, hepatic, celiac, and renal
rami, pharyngeal, pulmonary, and esophageal plexuses, and anterior and posterior trunks; distribution, descending
through the jugular foramen, it presents as a superior and an inferior ganglion, and continues through the neck and
thorax into the abdomen. It supplies sensory fibers to the ear, tongue, pharynx, and larynx, motor fibers to the
pharynx, larynx, and esophagus, and parasympathetic and visceral afferent fibers to thoracic and abdominal viscera;
…; modality, parasympathetic, visceral afferent, motor, general sensory.” Dorland’s at 1261.

                                                        167
she collapsed the morning of his testimony. He said, “I don’t know how well she’s doing or not.
It seems like a big mess to me.” Id.
       Dr. Steinman does not think the technician who did the brain scan finding marked
reduction in watershed profusion bilaterally could diagnose lupus or antiphospholipid antibody
syndrome from it, but he said that was just his doubting personality. Id. at 391-92. He thinks the
scan adds to the evidence that petitioner has something autoimmune going on. Id. at 392. Dr.
Steinman said he is not so impressed with these kinds of brain scans, but it was conducted not at
a highly respected institution that knows how to do these things. Id. at 393.
       The long QT is part of the abnormality of the autonomic nervous system. Id. The long
QT is a cardiac induction arrhythmia. Id. at 394. It sometimes has no consequences and
sometimes can produce very serious medical consequences. The undersigned asked Dr.
Steinman if he had any explanation for petitioner’s testifying that when her doctor increased her
dosage of IVIG, her myasthenia gravis got better but her dysautonomia got worse. Id. Dr.
Steinman said no, he did not. Id. at 395.
         Dr. Steinman posited that Fluzone containing H1N1 induces not only anti-myelin basic
protein antibodies, but also antiganglioside antibodies. Id. at 403. Although Dr. Steinman
opines there is a 15 to 20 percent binding level between a mimic in Fluzone to myelin, there is no
mimic in flu vaccine to the acetylcholine receptor. Id. at 409. However, the preganglionic axon
is likely myelinated and that is the connection to the 15 to 20 percent binding level between the
mimic in Fluzone to myelin. Id. at 410. The best argument he can muster is that flu vaccine
targets the myelinated preganglionic axon and induces an immune response with inflammation in
the preganglionic axon, inducing damage in the ganglion itself. Id. This is his answer for how
flu vaccine causes dysautonomia. Id. at 411. He cannot say what is a mimic between the
components of flu vaccine and ganglionic acetylcholine receptor. Id. at 411-12.
        Dr. Steinman gave an onset interval of 10 days for petitioner’s dysautonomia symptoms
after receiving flu vaccine on August 23, 2009. Id. at 415. He relates petitioner’s weakness,
dizziness, decreased appetite, nausea, and vomiting to dysautonomia. Id. at 416-17. These
symptoms occurred on September 12, 2009. Id. at 417. That is more like an onset of 20 days.
He attributes the same symptoms to myasthenia gravis as to dysautonomia and thus the onset of
myasthenia gravis is the same 20 days. Petitioner also had rhabdomyolysis in that same period.
Id. In attempting to link petitioner’s later diagnosis of gastroparesis, Dr. Steinman said once an
autoimmune autonomic nervous system disorder begins, it was “perfectly reasonable that other
manifestations will occur.” Id. at 419. Dr. Steinman agreed with Dr. Lancaster’s point in
Exhibit H that petitioner’s results for her gastric emptying study done on March 30, 2012 could
have been due to all the medications that she was taking affecting gastric motility. Id. at 424.
But, Dr. Steinman said that it does not mean she did not have gastric emptying problems. He
admitted petitioner is a very complex patient. Her gastric emptying study result was abnormal
and she was on a lot of medicines. He said, “We’re stuck.” Id.
        Dr. Steinman said petitioner has a variety of diagnoses. Id. at 427. He stated he said
directly and indirectly that myasthenia gravis was not his favorite diagnosis but a significant

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expert Dr. Sheean thinks petitioner has myasthenia or Lambert-Eaton Syndrome and Dr.
Steinman puts a high weight on an expert treating physician. Id.
        Dr. Steinman stated, “We’re not saying that it’s GBS here, we should make that clear.”
Id. at 430. He said we are not talking about GBS-related autonomic dysfunction. Id. at 434. We
are talking about the other end of the spectrum. We do not think it is GBS. Id. He agrees with
Dr. Lancaster that there is no evidence of petitioner having antibodies to myelin basic protein.
Id. at 435. Most normal people have responses to myelin basic protein (to HFFK). Id. He said
that autoimmunity in myelin basic protein has not been studied extensively in autoimmune
dysautonomia. Id. at 436-37. When Ms. Roquemore asked, referring to Dr. Lancaster’s
comments in his expert report (Ex. H), what are Dr. Steinman’s thoughts “that although GBS
was initially suspected by a few physicians, her preserved reflexes, normal EMG, NCS studies
and normal CSF proteins all rule out the diagnosis?” Dr. Steinman responded, “I don’t think I
base my opinion on GBS.” Id. at 637.
         Dr. Steinman does not think petitioner got better from chelation therapy, but from the
fluid loading. Id. at 439. He attributes petitioner’s confusion to anxiety. Id. at 440. Dr.
Steinman agreed he was neutral about whether petitioner has myasthenia gravis. Id. at 441-42.
He said the foreign accent was not associated with dystonia. Id. at 443. Dr. Steinman thinks
petitioner was manifesting anxiety, frustration, and fear, but he does not think that makes it a
conversion disorder. Id. at 444. He thinks doctors were perfectly reasonable to suggest anti-
anxiety treatments. He thinks dysautonomia is at the heart of the whole matter. Id. Dr.
Steinman thinks dystonia as a manifestation of dysautonomia could be due to an autoimmune
disease. Id. at 445. A vaccination could cause dystonia if it were due to an autoimmune problem
and if it is a manifestation of the dysautonomia. Id.
        On the third day of testimony, on cross-examination, Dr. Steinman said the first time he
met petitioner was at the hearing. Id. at 467. He stated that petitioner’s injury is restricted to the
autonomic nervous system and the vagus nerve.161 Id. at 467. He said petitioner’s case is
complex and whether or not she has myasthenia is not central to his conclusions. Id. at 469. He
does not think petitioner had Lambert-Eaton syndrome, which Dr. Sheean included in a
differential diagnosis. Id. The undersigned asked Dr. Steinman if the undersigned held
petitioner did not have myasthenia gravis, would Dr. Steinman’s opinion be she still had
dysautonomia and the vaccine caused everything she has, and he said that is a very accurate
summary of his reasoning. Id. at 471. Dr. Steinman said myasthenia gravis is “not a
cornerstone” of his thinking. Tr. at 475.
       As for foreign accent syndrome, Dr. Steinman explained petitioner has bulbar weakness
from involvement of her autonomic nervous system, controlling speaking and breathing. Id. at
476. She could not speak naturally unless she breathed physiologically. He also said if

161
    “Vagus nerve damage can occur following upper respiratory viral infections. These infections initially involved
symptoms such as cough, nasal congestion and runny noses. Symptoms that persisted in patients identified as
having post viral vagal neuropathy, or PVVN, included cough, throat clearing, difficulty speaking and vocal
fatigue.” What Are the Causes of Vagus Nerve Damage?, LIVESTRONG, https://www.livestrong.com/article/148586-
what-are-the-causes-of-vagus-nerve-damage/ (last visited April 9, 2019).

                                                       169
petitioner had abnormal breathing due to mechanisms controlling her diaphragm through her
vagus nerve, that could also cause foreign accent syndrome. Id. He said, “I’ll say, frankly, right
now, it’s not the case in such a complex spectrum of behavioral abnormalities that I am even
going to attempt to say that I can explain everything by point A or B.” Id.
        Dr. Steinman continued:
                 Your very good questions force me to think, and the vagus nerve,
                 heavily myelinated, a cornerstone of my argument is that there is
                 molecular mimicry to myelin. She may have abnormalities of her
                 vagus nerve that contribute to POTS and her orthostatic
                 tachycardia. It may interfere with her respirations.
Id. at 477. Dr. Steinman then proceeded to imitate talking nasally as if he had respiratory
problems. The undersigned said that he did not sound as if he comes from England. Id.
        The undersigned reminded him that he linked petitioner’s foreign accent syndrome to her
having myasthenia gravis and asked him if it were affiliated with other conditions. Id. at 478.
Dr. Steinman responded that he was not “the definitive authority on foreign accent syndrome”
and could only say it would not be specific only to myasthenia gravis. Id. Dr. Steinman
continued, “I’m not personally wild about myasthenia” and repeated his admiration for Dr.
Sheean. Id. at 480-81.
        Dr. Steinman said, “I’ve mentioned that there are certain aspects of this case that I
thought long and hard about on do I want to come here and put my reputation on the line? And
I’m here. And I feel very strongly about this case.” Id. at 484-85. He repeated he is “not a
world’s expert on foreign accent syndrome.” Id. at 486. He said it was a tough call whether
petitioner has a psychiatric or organic illness or both. Id. at 487.
        Dr. Steinman questioned whether the vagus nerve was central or peripheral. Id. at 491. It
has a huge, wandering path. He does not make this separation. He said dystonia can affect both
the autonomic and non-autonomic parts of the nervous system. He has been thinking about it as
mainly a central nervous system disorder, but then the autonomic nervous system has a central
input. Id. at 491. He said there are amazing linkages between the peripheral and central nervous
systems. Id. at 491-92. He believes that petitioner had dystonia and it was a manifestation of
dysautonomia. Id. at 492. He did not think petitioner had dystonia until he saw petitioner’s
weird movements going away when she walked backward in the videos. Id. at 492-93. He
questioned how anyone could ever know162 that walking backward would make her flailing go
away. Id. at 493.

162
   Dr. Steinman must not have watched the videos in which petitioner’s then-husband said petitioner looked up
dystonia on the Mayo Clinic website and learned about sensory tricks after the Johns Hopkins physical therapist told
her she had dystonia. Ex. 58, Video #409_0279_01. This was not the first time petitioner looked up a disease on
the Internet. She told Dr. Mannon at Inova Fairfax Hospital on September 26, 2009 that she looked up Lyme
disease on the Internet because she knew people who had it and she thought she did, too. Med. recs. Ex. 44, at 14.

                                                        170
        Dr. Steinman said that if the vagus nerve is impaired, a person can get autoimmune
diseases. Id. at 496. If you stimulate the vagus nerve, you can overcome the issues resulting
with vagal nerve abnormality. He mentioned articles by Kevin Tracey which were not in
evidence to support his statement. Id. Dr. Steinman thinks vagal nerve abnormality caused
petitioner autoimmune dysautonomia. Id. at 497. Dr. Steinman said he could analyze whether a
symptom was autonomic or non-autonomic only on a case by case basis. Id. at 499.
        Dr. Steinman thinks that petitioner responded to Dr. Buttar’s treatment because IV
therapy improves POTS. Id. at 502. He thinks petitioner’s POTS is autoimmune and part of her
dysautonomia. Id. at 503. Dr. Steinman testified that he has never seen any evidence that
hyperbaric therapy works for anything but diving injuries. Id. at 504. Dr. Steinman clarified his
opinion by stating that POTS would not have anything to do with petitioner’s ability to walk
forward when she embraced her husband and said she was healed. Id. at 505. He said POTS
would apply only to her cardiac physiology, but it would be part of a broader dysautonomic
syndrome and the dystonia was due to an autoimmune dysautonomia. Id. When the undersigned
asked Dr. Steinman why the IVs’ improving her blood volume would help petitioner walk
forward and speak normally, Dr. Steinman said, “I can’t integrate all of these things, no. I could
try, but I’m not going to.” Id. at 506. He went on to explain the placebo effect:
               So, in imparting to an individual that something is going to help
               them, we humans are complex, we often get more of a positive
               response. You know, if you could put a placebo effect in a bottle
               and make a drug out of it, part of it is that art of practicing, and
               maybe Buttar and maybe this other guy, they’re good salespeople,
               and they tell somebody they’re going to be better and they are
               better for a while.
               So, there may be inconsistencies, and believe me, I saw
               inconsistencies in the films and in the history, not everything
               satisfied me 100 percent, but in sum, and in summary, not – I felt
               that there’s clearly something organic going on, and then I made a
               theory.
Id. at 507.
        He continued explaining the placebo effect:
               And I’m implying when a person has a positive response or even
               thinks they’re [sic] having a positive response, there may be a
               ripple effect into other areas, and she may, indeed, be – you know,
               do better in other areas for a while.
Id. at 508.
       Dr. Steinman said he considers autoimmune dysautonomia and autoimmune autonomic
neuropathy as equal. He stated autoimmune autonomic neuropathy can involve either the
peripheral nervous system or central nervous system or both nervous systems. Id. He considers

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petitioner to have autoimmune autonomic ganglionopathy which is negative for antibody to
ganglionic acetylcholine receptors. Id. at 510. He testified autoimmune autonomic
ganglionopathy is subsumed in autoimmune dysautonomia. Id.
       Dr. Steinman admitted that he included in a chart (Ex. 93) he created of doctors who
diagnosed petitioner with autoimmune dysautonomia the name of Dr. Urrutia at Johns Hopkins
University without also including Dr. Urrutia’s later note that petitioner’s symptoms did not fit a
physiologic paradigm and, instead, might be her reaction to anxiety. Id. at 514, 515.
        Dr. Steinman admitted that volume correction of petitioner’s POTS from Dr. Buttar’s IV
treatment would not explain petitioner’s positive response to Dr. Buttar’s rubbing transdermal
DMPS drops on her arms, and Dr. Steinman noted for the transcript of the hearing that he
laughed in agreement with respondent’s counsel’s question (“let it be known for the record that I
had to laugh in agreement”). Id. at 518.
         Dr. Steinman said that the ability to walk backward and sideways but not forward is
symptomatic of dystonia, but not myasthenia gravis, recognizing an error in his list of symptoms
common to each disease (Ex. 94). Id. at 525, 526. In a list (Ex. 94), he said that cold spots in the
back of petitioner’s head were irrelevant for autoimmune dysautonomia. Id. at 527. But in a
later list of symptoms of autoimmune dystonia (Ex. 175), he admitted he made a mistake when
he included cold spots in the back of petitioner’s head. Id. at 528. Dr. Steinman said, “And as
I’m sitting here, I don’t put a lot of – I can’t explain, as I sit here today, what on Earth the cold
spots in the back of the head was all about.” Id. at 529.
        Dr. Steinman admitted that his understanding was that 2009 Fluzone vaccine that
petitioner received in 2009 was composed of A/California/2009, A/Victoria/2009, and
B/Brisbane/2008, and could induce anti-myelin basic protein antibodies and antiganglioside
antibodies. Id. at 530. He also said he based the symptomatology portion of his molecular
mimicry theory on the components A/California and A/Victoria strains that he believed were in
the 2009 Fluzone vaccine that petitioner received. Id. at 530-31. Respondent then introduced
Exhibit WWW, which was a Sanofi-Pasteur press release stating the actual components of the
2009 Fluzone vaccine (which were not what Dr. Steinman had based his opinion on). Id. at 531,
532. The three components were A/Brisbane strain H1N1-like virus, A/Brisbane strain H3N2-like
virus, and B/Brisbane strain-like virus. Id. at 532. Dr. Steinman admitted there was a
discrepancy in what he conceived were the components with what were the actual components in
the vaccine petitioner received. Id. He said it would require a little detective work. Id. at 534.
Dr. Steinman had looked at the wrong flu season (2010-2011) for his understanding of the
components of Fluzone in 2009. Id. at 535.
        On redirect, Dr. Steinman said the most important mimic known is the antiganglioside.
Id. at 542. All these different viruses will elicit antiganglioside independent of their differences
in protein structure. Id. at 543. They have enough sites in their proteins to get glycosylated. If a
hemagglutinin gets glycosylated with a ganglioside, it can elicit antiganglioside antibodies. He
said many questions remain unanswered why only once in a while does epidemiology reflect

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this, but he thinks it is highly likely that the 2009 vaccine petitioner received could elicit an
antiganglioside antibody. Id.
                                    Dr. Lancaster’s Testimony
        Dr. Eric Lancaster testified for respondent. Id. at 547. Dr. Lancaster is an assistant
professor at the University of Pennsylvania, conducting research concerning the mechanisms of
autoantibodies to different brain and peripheral nerve proteins, to provide clinical care for
patients in his clinic which mostly focuses on people with autoimmune neurological conditions,
and to assist with diagnostic testing of autoantibodies for patients with various forms of
suspected autoimmune encephalitis. Id. at 548-49. He also educates residents, fellows, and
medical students. Id. at 549. He has a Ph.D. in neuroscience. The topic of his thesis was the
response of autonomic neurons of the vagus nerve to injury. He is board certified in neurology,
neuromuscular medicine, and electrodiagnostic medicine. Id. He sees patients with various
forms of autoimmune encephalitis, autoimmune neuropathies, autoimmune neuromuscular
junction disorders, and antibody-mediated neurological problems. Id.
        Dr. Lancaster has diagnosed and treated about 30 patients with dysautonomia. Id. at 550.
He has diagnosed and treated about 30 patients with myasthenia gravis. He has seen about five
patients with autoantibodies to the ganglionic acetylcholine receptor. Id. He has diagnosed and
treated patients with dystonia. Id. at 551. Dr. Lancaster has done research on the response of
vagal sensory neurons to injury, which is an important part of the autonomic nervous system. Id.
Dr. Lancaster believes that dystonia and dysautonomia are very different and need to be
considered separately. Id. at 552. Respondent offered Dr. Lancaster as an expert in neurology
and autoimmune neurological disorders and diseases. Id. at 553. Petitioner had no objection.
Id. at 554.
        Dr. Lancaster’s opinion is that petitioner’s primary diagnosis is conversion disorder. Id.
at 554. Dr. Lancaster explained conversion disorder is a subconscious response to stress. Id. at
555. A person with conversion disorder can manifest many abnormal medical problems for
which a physiologic explanation does not exist, but subconscious stress is the explanation for the
manifestations. Some of the most common manifestations of conversion disorder occur in
neurology, e.g., events that look like seizures, but do not involve actual seizures in the brain, but
are precipitated by stress rather than by an abnormal discharge of electricity among neurons in
the brain. Id. Other manifestations might include an abnormal gait. Id. Further manifestations
might be weakness for which no physiologic cause is apparent or is likely to exist. Id. at 556.
Some patients can have more than one manifestation. Conversion disorder problems are
relatively common in neurology. Dr. Lancaster has had about 50 to 100 patients with conversion
disorder. It is not a rare problem. Id.
        Dr. Lancaster said that a person manifesting conversion disorder generally is not
conscious of what is causing his or her symptoms. Id. at 557. Dr. Lancaster distinguished
between someone with conversion disorder and a malingerer. A malingerer consciously decides
to fake a medical illness with a concrete goal. For example, someone who pretends to have a
cold to call in sick in order to go out and play golf is a malingerer. Conversion disorder is

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subconscious. There is no apparent gain for the patient. In many cases, what the person with
conversion disorder is doing makes his or her life difficult, more unpleasant, and could
eventually hurt him or her. Id.
       Dr. Lancaster stated that a neurologist, rather than a psychiatrist, more often diagnoses
conversion disorder. Id. at 558. He stressed the extreme importance of excluding physiological
causes. He stated specific clues often suggest the diagnosis of conversion disorder. Id.
        Dr. Lancaster testified that petitioner had a variety of symptoms in the first several
months after her supposed seizures that in totality do not admit to an organic or physiologic
cause. Id. at 559. She had many different manifestations. Some that were most prominent and
aid in diagnosing her with conversion disorder include repeated attacks of severe weakness
resulting in apparently profound inability to move, followed by a rapid recovery. Other events
included the unusual nature of her walking problem with a wildly lurching gait that made
petitioner seem profoundly off balance and yet required her to have a great deal of balance to
perform. Dr. Lancaster said this manifestation is called astasia-abasia, which is seen in the
videos. Id.
       Another manifestation of petitioner’s conversion disorder is her speech problem which
was inconsistent with an organic etiology, in Dr. Lancaster’s opinion. Id. at 560. Her speech
problem fluctuated among four or five different presentations, as apparent on some of the videos.
        Dr. Lancaster said another manifestation of petitioner’s conversion disorder was the
nature of her responses to some of her tests, e.g., her first tilt-table test. Id.
         In sum, Dr. Lancaster could not give any physiologic explanation for the great majority
of petitioner's most serious and impairing symptoms in the first three months or so after the onset
of her condition and concludes she had conversion disorder. Id. The objective testing at Johns
Hopkins and other centers was extremely helpful in ruling out an organic etiology. She had
normal brain MRIs, normal nerve conduction studies and EMGs on several occasions, normal
lumbar puncture result, and normal EEGs. Id. Her tilt-table testing was also extremely helpful
because she had profound and impairing symptoms when tilted, but her blood pressure remained
normal. Id. at 560-61. In other words, she did not have hypotension as the cause of her
symptoms. Id. at 561.
        Dr. Lancaster said that the physicians who were directly observing petitioner and
maintained medical records in the first three months after the onset of her condition often
suspected a psychiatric etiology. Many of them saw her gait and thought it did not have an
organic basis or observed other symptoms which they wrote did not have an organic basis. The
later records of physicians who did not observe petitioner early may not have had all the
information. Id. The video evidence was extremely helpful. Id. Normally. Dr. Lancaster said
he would spend an hour with a patient in the office to diagnose him or her with conversion
disorder. Id. at 562. With the videos of petitioner, Dr. Lancaster said he was able to observe
petitioner’s behavior directly over a long period of time, i.e., many hours. He was able to stop,
go back, view something again, look at it in detail, observe petitioner’s gait, speech, and other

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symptoms. Dr. Lancaster said petitioner is the person with conversion disorder that he has been
able to study in the most detail because of the videos. Id.
        Dr. Lancaster stated that the videos show petitioner having very rapid changes in her
level of strength, in her apparent level of consciousness, with wild shaking-like events taking
several forms, shaking limbs at rest, shaking limbs with movement, shaking of her head, and
forward thrusting of her head. They also show multiple changes in her speech, sometimes
speaking with a “flat out” British accent or close to it. Id. They show that sometimes she spoke
in a slow and exaggerated way that was harsh and strained. Sometimes she spoke very quietly
and whispered. Sometimes she shifted rapidly from one to another. Id. at 562. He thinks there
were at least five distinct changes. Id. at 562-63. He said, “The fact that there were just so many
different manifestations of the dysarthria weighs pretty heavily against an organic cause.” Tr. at
563.
       As for petitioner’s gait, the videos show her walking in the characteristic way of astasia-
abasia where she appears wildly off balance, lurching forward, jerking violently as she is
moving, and yet not falling down, maintaining excellent balance. Id. Dr. Lancaster said it takes
balance and strength to perform that. Someone who was off balance or uncoordinated could not
perform that and would fall down. Id.
         Dr. Lancaster said he observed events that were highly characteristic of nonepileptic
spells, sometimes call nonepileptic seizures which are not really seizures but rather psychiatric
seizures. For instance, petitioner would appear to have profoundly altered consciousness and yet
still respond to people. She would still be able to move both her arms during an attack. She
would close her eyes and shake her extremities during an attack. Id.
        Dr. Lancaster also called attention to the profound effect of suggestion in the videos. Id.
at 564. He said Dr. Buttar gave petitioner “an incredibly powerful treatment” in his office, i.e.,
suggestion. Dr. Lancaster stated Dr. Buttar in the videos would tell petitioner that something
was going to work and help her and, in agreeing with Dr. Steinman, Dr. Lancaster said there was
“an incredibly powerful placebo effect” to which petitioner had a great response. Dr. Lancaster
said that it did not seem to matter what the exact physical treatment was. But any time someone
suggested the treatment would work for petitioner, it did profoundly, at least transiently. Id. Dr.
Lancaster said he did see in the videos that petitioner had tremors, which he would describe as
psychogenic tremors. Id.
       Dr. Lancaster’s opinion is that the August 23, 2009 flu vaccination is highly unlikely to
have resulted in an adverse reaction. Id. His reason is that conversion disorder is a
manifestation of stress and flu vaccine does not cause it. Id. at 565.
        Dr. Lancaster described the autonomic nervous system. It refers to the very specific parts
of the nervous system that handle a small subset of neuronal functions that are completely
outside conscious control. These specific functions include regulating the following: blood
pressure; heart rate; sweating; salivation; tearing; and the size of the pupil. Id. The autonomous
nervous system is sometimes divided into components, such as the sympathetic nervous system
(controlling mostly sweating, cardiovascular responses, dilating of the pupils), and the

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parasympathetic nervous system (controlling salivation, moving of the intestinal tract, slowing
down the heart rate, constricting the pupil, and assisting with urination). Id. at 565-66.
        Sometimes, doctors include the enteric nervous system as part of the autonomic nervous
system. Id. at 566. The gut itself has as many neurons as the spinal cord in order to allow the
gut to squeeze properly and coordinate its motions. Thus, the enteric nervous system constitutes
the third main component of the autonomic nervous system.
        Dr. Lancaster said the autonomic nervous system is mostly in the periphery, involving
nerves running out to the heart, glands, blood vessels, skin (to control sweating and goose flesh).
He stated the autonomic nervous system also has a central component that is a very small part of
the central nervous system, involving monitoring and controlling these bases on a central basis.
Id. For example, the light pathways, when a light shining in one’s eye constricts the pupil, is part
of the autonomic nervous system. Id. at 566-67. The central pathways for regulating one’s
temperature and determining whether someone should be sweating or shivering is considered
part of the autonomic nervous system. Id. at 567.
       Dr. Lancaster stated it is important to distinguish what the autonomic nervous system
does not do, such as voluntary motion which voluntary motor control performs from the brain
through the spinal cord to the peripheral nerves to muscle. Walking involves the activation of
muscles from the nerves directing those muscles to work and is not based in the autonomic
nervous system. Id. He noted that “autonomic” does not mean “unconscious.” Id. Dr.
Lancaster said that speech, understanding speech, visual perception, and hearing are completely
outside voluntary control but are not considered part of the autonomic nervous system. Id. at
568. Balance is generally outside voluntary control and is not considered part of the autonomic
nervous system. The perception of light and sound are not considered part of the autonomic
nervous system. Thus, there are small parts of the central nervous system that are autonomic.
Id. There are also parts of the peripheral nervous system that are considered autonomic that do
very specific things. Id. at 569.
        The undersigned asked Dr. Lancaster what the vagus nerve is. He replied the vagus
nerve comes out of the brainstem, travels a long, winding course, and touches many inner
organs. The vagus nerve is mostly autonomic and considered part of the parasympathetic
system. Its autonomic functions include slowing the heart rate and balancing out the sympathetic
tone that could increase heart rate. It helps the intestines move food along and tells the intestines
to digest faster when someone puts food in his or her mouth and into his or her stomach. It
mediates the activity of the liver with glucose control. It also has some role in sensing blood
pressure. Id.
       Dr. Lancaster disagrees with Dr. Steinman that the vagus nerve controls breathing. Id. at
569-70. Dr. Lancaster said the phrenic nerve which is under voluntary control and not part of the
autonomic nervous system controls breathing. Id. at 570. He said the vagus nerve also has some
components that are not autonomic.
         Dr. Lancaster said a long QT is not autonomic. Id. at 572-73. The QT refers to the fact
that, as the heart contracts, it conducts electrical signal across itself through the heart muscle

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cells. Id. at 573. A long QT means that one part of that conduction pathway is too slow. That is
a process with the heart muscle cells that conduct the electricity, not with any nerve cell. When
someone has a long QT, he or she has a problem with the conduction of certain muscle cells
within the heart that are supposedly specialized to conduct the impulse rapidly through the heart.
In order for some disease to cause a long QT, there must be a mechanism for that disease to
affect heart muscle cells, not nerve cells. Dr. Lancaster said that there is nothing anyone can do
to a nervous system to give someone a long QT syndrome. It is a cardiac conduction
phenomenon. Its cause can be genetic, drugs, or toxins. Id. Dr. Lancaster said he does not
know why petitioner has long QT syndrome. Id. at 574. He does not think she has
dysautonomia per se. The long QT syndrome could be from any of the number of medications
petitioner is on. Perhaps she developed it over time. Id.
        Returning to digestion, Dr. Lancaster said that moving of the tongue, chewing, and initial
swallowing are not autonomic. They are under voluntary control. Salivation and drooling are
autonomic. Id. Beyond the initial voluntary initiation of swallowing, from the lower two-thirds
of the esophagus on down is considered autonomic. Id. at 575.
       Speaking is not a function of the autonomic nervous system. The vocal cords, the tongue,
and the mouth are under voluntary control. Dr. Lancaster’s opinion is that petitioner does not
have myasthenia gravis.
        Dr. Lancaster said his definition of the autonomic nervous system is widely accepted in
the neurologic community and would come straight out of any neurology textbook or any
prominent review of the subject. Id. For example, orthostatic hypotension means one’s system
for maintaining blood pressure is not working right and becomes stressed when one stands up.
Id. at 577. When one stands up, one becomes dizzy and might pass out or become lightheaded.
If one lay down again, the symptoms would rapidly resolve. Someone could make too much
saliva (drool) or too little saliva. Id. Someone with autonomic nervous system disease might
have trouble squeezing his or her bladder out or allowing the bladder to relax and accommodate
fluid. Id. at 577-78.
        Dr. Lancaster said cognition is not considered an autonomic function. Id. at 578. The
only connection between cognition and autonomic function is the maintenance of blood pressure
which enables someone to think. If someone stands up and cannot maintain his or her blood
pressure, he or she will feel dizzy and pass out. Id. Someone’s consciousness, thoughts,
emotions, feelings, understanding, and memory are not autonomic, and the autonomic nervous
system does not directly control them. Id. at 579. The medical community does not consider
the autonomic nervous system as the mediator of dystonia. Dystonia is an abnormality of motor
control involving areas in the brain that control and execute movements. Nothing in the
peripheral nervous system causes dystonia. It is a problem of voluntary muscles. It is a problem
of the central nervous system. Id.
        Dr. Lancaster said the most common form of dystonia is writer’s cramp in which, while
someone is writing, the motion triggers hyperexcitability in certain motor pathways, generally in
the brain, and the hand locks into an uncomfortable position for a period of time. Id. at 579-80.

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He stated another form of dystonia might involve the leg as someone is walking. Id. at 580. The
leg might have abnormal tone, and the leg would be turned in and extended at the ankle. Vocal
dystonia involves having a fixed, hoarse, or strained voice. Motion can trigger some dystonia
while other dystonia occurs constantly whether the person is moving or not. Some dystonia can
activate part of the sympathetic nervous system rarely when a hand might feel clammy and cold
while contracted. That would be very unusual. The overwhelming manifestation of dystonia is
an abnormality of the voluntary motor control system, not the autonomic nervous system. Id.
Dr. Lancaster testified that the Marsden and Fahn articles describing torsion dystonia in children
and sometimes adults, involving walking backward while unable to walk forward, are describing
a central nervous system condition. Id. at 580-81. Dr. Lancaster said that the overwhelming
majority of neurologists would be shocked and surprised to hear anyone attributing a complex
motor coordination problem to dysautonomia, rather than the central nervous system. Id. at 580.
        Dr. Lancaster then discussed the Marsden article which he said is an excellent description
of patients with dystonia involving many classic features. Id. at 582. Dr. Lancaster thinks the
patients in the article most likely had a genetic disease, not an autoimmune disease. Those
patients sometimes have complex gait disorders, but not astasia-abasia. Dr. Lancaster also noted
that once these patients had onset of dystonia, their dystonia tended to be the same for years.
Their manifestations of dystonia are relatively static or worsen over time. They do not have one
kind of wild lurching movement one day and then it is all gone and then a completely different
wild movement the next day, and yet another movement the third day, and then it is all better.
Id. Dr. Lancaster said that IVIG would be completely useless to treat patients with dystonia
because it is not autoimmune. Id. at 583.
       Dr. Lancaster said there are very rare autoimmune diseases that might manifest dystonia
for which he would use immune therapy. For instance, someone with anti-NMDA receptor
encephalitis might have dystonic posturing as part of that brain disease. Id.
        Dr. Lancaster said that Fahn in Ex. 129 described the clinical variance of idiopathic
torsion dystonia. Id. at 584. Since the publication of Fahn’s article, some of these unknown
(“idiopathic”) causes have turned out to be genetic. Dr. Lancaster does not believe the neurology
community believes that idiopathic torsion dystonia is an autoimmune disease. It would be very
surprising to treat such a patient with IVIG or steroids. Id.
        Dr. Lancaster explained why notable treating doctors such as Dr. Grubb, Dr. Sheean, and
Dr. Atiga diagnosed petitioner with either dysautonomia or myasthenia gravis because they did
not have the privilege of observing all of petitioner’s florid symptoms of conversion disorder
early on in 2009. Id. at 585. By the time, in 2012 or 2013, petitioner saw these doctors, the
medical records mention the gait disorder much less often or not at all during a visit. Id. at 585-
86. Her abnormal movements and seizure-like events were mostly gone. Id. at 586. Dr.
Lancaster contrasted these doctors with Dr. Urrutia who saw petitioner early on and suspected a
psychogenic etiology. Id.
       Moreover, Dr. Lancaster explained that the later doctors were working with limited
information and would write down petitioner’s history that she had a positive tilt-table test,

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which they would accept at face value. Id. But, Dr. Lancaster continued, if they had read the
original tilt-table report, it is unclear if it concluded petitioner had autonomic dysfunction. Id.
What happened in the first tilt-table test is that they tilted petitioner to an upright position and
she had a long period of normal blood pressure and normal pulse, while at the same time, she
manifested florid symptoms of abnormal speech and feeling profoundly unwell. Id. at 587. That
is not an autonomic problem. That was not a blood pressure regulation problem. The
mechanism of blood pressure problems is dropping the blood pressure. If petitioner had an
autonomic disorder, when she was upright after being tilted, her blood pressure would drop, her
brain would not be well-profused, she would feel lightheaded and unwell, and perhaps she would
pass out. Id. Dr. Lancaster thinks in many of the later doctors’ cases, they were working with
incomplete information.
        As for petitioner’s gastrointestinal concerns, she had a number of normal studies early on.
Id. Dr. Frisca Yan-Go, an expert autonomic neurologist, reviewed all petitioner’s tests and
concluded petitioner did not have significant autonomic disorder. Later on, petitioner had one
abnormal gastric emptying test result while she was taking Sandostatin, which can cause that
result on the test. Id.
         As for petitioner’s having myasthenia gravis, that is a difficult diagnosis. Id. at 588.
Petitioner had patterns of fluctuating weakness. Ninety percent of patients with myasthenia
gravis have antibodies to acetylcholine receptor and MuSK. Petitioner did not. Then she was
tested with the repetitive stimulation test and that was normal. But ninety percent of myasthenia
gravis patients have an abnormal result. Dr. Lancaster asked would one or two percent of
myasthenia gravis patients have both a negative antibody to acetylcholine receptor and MuSK
and negative repetitive stimulation test. He concluded that the myasthenia gravis diagnosis of
petitioner did not have much in the way of actual factual basis to support it. Then, looking back
at petitioner’s episodes of profound weakness that instantly got better, episodes of slurred speech
that got better, Dr. Lancaster thinks what was actually happening was ongoing conversion
disorder. The more florid manifestations of petitioner’s conversion disorder became much more
subtle over time. Id.
       Dr. Lancaster noted that petitioner’s antibody tests were done both before and after she
went on IVIG. Id. at 589. They were widely separated in time. He does not think IVIG would
make the antibody test negative. Patients with myasthenia remain antibody positive for years
and years, even when they go into clinical remission. Those who are antibody negative do not
have myasthenia any more. Id.
        Dr. Lancaster said petitioner took a second tilt-table test. Id. at 590. The first tilt-table
test was July 15, 2010 (Ex. 23, at 1,2) and the second one was on September 9, 2010 (Ex. 37).
Id. at 590-91. The second tilt-table test was done at Ohio State University and the findings were
normal but for variable blood pressure and pulse pressure during 15 minutes of orthostatic stress.
Id. at 591. Heart rate increased by 35 beats per minute to an absolute maximum of 123 beats per
minute. Petitioner had normal heart rate variability in response to deep breathing. Ohio State’s
conclusion was that petitioner’s tilt-table results were consistent with grade two orthostatic
intolerance, POTS, a conclusion with which Dr. Lancaster disagrees. Id.

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         Dr. Lancaster referred to the Plash article (Ex. E), which is a study of different diagnostic
criteria using tilt-table testing to diagnose patients positive or negative for POTS. Id. at 592. Dr.
Lancaster said the key question is for what length of time should technicians tilt their patients
and how high should a patient’s pulse go in order to differentiate normal patients from those with
POTS. He described the Plash article as trying a number of different conditions. Id. at 592. He
said another important component was whether to use standing or tilting as the more likely
determinant of who is normal and who has POTS. Id. at 592-93. Dr. Lancaster stated the
question is whether to use an increase of 30 or 37 beats per minute and whether to tilt the patient
up for 10 minutes and keep observing the patient for that increase or to tilt the patient up for 30
minutes and observe the patient for all that time to see if there is an increase. Id. at 593. The
Plash article states that a 10-minute tilt correctly identified 93 percent of POTS patients, but also
identified 60 percent of normal control subjects as having orthostatic tachycardia, which was a
false positive. Id. This suggests that tilting for 10 minutes, 30 beats per minute, is highly
sensitive but has poor specificity, that is, it classifies normal people as positive. Id. at 593-94.
The Plash authors found that increasing the heart rate cutoff between POTS and normal to 37
beats per minute resulted in a more specific test which had good sensitivity. Id. at 594.
        As for the second tilt-table test petitioner took at the University of Ohio (Ex. 37). Dr.
Lancaster said that petitioner had an increase of heart rate by 35 beats per minute at 15 minutes
into the test. Id. He noted that between 10 and 30 minutes, from 40 to 80 percent of normal
people have the same result. Id. Dr. Lancaster stated this is an extremely non-specific finding
that a great number of normal people have. Id. at 594-95. He said that petitioner’s second tilt-
table test was not “gold-plated” evidence that she has an autonomic disorder. Id. at 596. He
does not think the results of this test diagnose petitioner with POTS or autonomic dysfunction.
        Dr. Lancaster then looked at the first tilt-table test done July 15, 2010, which was 10
months after vaccination. Id. The test results were normal heart rate and blood pressure
responses to upright tilt-table test. Id. Provocation with nitroglycerin reproduced and worsened
petitioner’s symptoms, which the technicians thought indicated petitioner had a form a cerebral
syncope in which she had dysregulation of cerebral blood flow when upright, especially with
orthostatic stress. Id. at 596-97. Dr. Lancaster disagreed with this assessment. He thought the
results weighed against petitioner having an autonomic disorder because petitioner was able to
regulate her blood pressure during the test. Id. at 597. He does not think that focal regulation of
cerebral blood flow when upright is a well-established disease. Id. He does not know why the
technicians gave petitioner nitroglycerin, which is a vasodilator. Id. at 598. Dr. Lancaster does
not agree with the cerebral diagnosis and thinks it relates to the issue of the PET scan, where the
technician thought there was a focal abnormality in distributing blood around her brain. Id. at
598-99. He thinks the technician got one abnormal SPECT scan to support that diagnosis, which
Dr. Lancaster noted Dr. Steinman was skeptical about and Dr. Lancaster entirely agrees that
those tests are very non-specific. Id. at 599. Petitioner had a subsequent PET scan of her brain
that did not show any abnormality at all. Id.
       As for petitioner’s doctors diagnosing her with illnesses she did not have, Dr. Lancaster
explained they were recording what petitioner told them, oftentimes a diagnosis outside their

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specialty which they did not personally check out or create for themselves. Tr. at 601. For
instance, Dr. Atiga, a cardiologist, repeated petitioner’s diagnosis of dystonia even though he is
not a neurologist and did not check that petitioner had dystonia. Id.
        Dr. Lancaster testified that dysautonomia does not impact cognition. Id. He said that
dysautonomia does not impact a person’s ability to speak or pronounce words. Id. at 601-02.
Dr. Lancaster also stated that dysautonomia does not impact someone’s gait. Id. at 602. If
someone did not have sufficient blood pressure, he or she might get lightheaded or fall down, but
not otherwise have an abnormal gait. There is a form of dysautonomia that is autoimmune,
which is autoimmune autonomic neuropathy sometimes called autoimmune autonomic
ganglionopathy. In most cases, it is a relatively acute illness with a timing similar to that of GBS
over several weeks or months with a profound failure of the autonomic nervous system. Id.
Patients with autoimmune autonomic neuropathy manifest pupils unresponsive to light which
might be completely fixed. Id. at 603. They are unable to salivate. They have profound
inability to maintain blood pressure. If you give them a tilt test, their blood pressure drops
straight down to 40/20 and they are out. For people with autoimmune autonomic neuropathy,
their heart rates are fixed like a machine and do not vary. They have profound abnormalities in
sweating. Huge parts of their bodies are unable to generate any sweat. They might have
profound gastroparesis such that if they put food in their stomach, nothing happens. Autonomic
autoimmune neuropathy is not subtle. They have sexual dysfunction and urinary dysfunction.
Id.
         Dr. Lancaster stated that half these patients have an antibody to the form of the
acetylcholine receptor expressed almost entirely in the autonomic nervous system, called alpha 3
acetylcholine receptor. Id. at 604. Dr. Lancaster said that petitioner does not have this clinical
picture. Her medical records do not document any significant problem with her pupils, any
failure of salivation, any failure of sweating, or urinary or sexual dysfunction. Her
cardiovascular tests do not show any significant abnormality in maintaining her blood pressure in
response to several stresses. The fact that she could run an 8K race near the peak of her
symptoms indicates her excellent cardiovascular sympathetic function. When someone runs, he
or she has to increase his or her cardiac output, i.e., the amount of blood being pumped by the
heart, by five or six times above normal. Id. It goes to 500 percent of normal. Id. at 604-05.
Someone running has to make the heart beat about three times faster, squeeze about twice as
much blood in each squeeze, and control the tone in all the other major arteries of his or her body
to distribute it to the most active muscles and constrict other blood vessels to maintain the tone
so that the quadriceps muscles get their fair share and keep it from getting to the brain and
kidneys. Id. at 605. Dr. Lancaster said maintaining blood pressure during an intense prolonged
run is an “amazing feat of the autonomic nervous system.” He notes petitioner did it perfectly.
Id.
         Diagnosing autoimmune autonomic gangliopathy would include the most useful test, i.e.,
the test for ganglionic acetylcholine receptor antibody. Id. If a patient does not have that
antibody, Dr. Lancaster said he would not be totally sure what that patient had. Id. at 606.

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         Dr. Lancaster said that dysautonomia is not a variant of GBS. Id. at 607. In patients with
GBS, the predominant symptoms are in the non-autonomic parts of the peripheral nervous
system including demyelination of the nerves that allow someone to move his or her muscles and
to feel sensations. Id. Some patients with GBS also have significant effects on their autonomic
nervous system. Id. at 607-08. Dr. Lancaster said he does not know how anyone could diagnose
someone with GBS who has an isolated autonomic syndrome. Id. at 608. It does not make sense
to him and he does not think most neurologists would accept it. Patients with GBS who have
autonomic failure have overwhelming evidence of weakness and numbness in the non-autonomic
parts of their nervous system. The weakness and numbness tend to peak at the same time as the
autonomic failure rapidly improves when the person gets better. Id.
       Dr. Lancaster said he disagrees with Dr. Steinman on several levels. He said petitioner
has conversion disorder, not an autonomic disorder, not autoimmune autonomic neuropathy, and
not some sort of autonomic-only version of GBS. Id.
        Dr. Lancaster defined dystonia as a complex and abnormal contraction of certain muscle
groups, either with motion or at rest. Id. at 609. The brain primarily mediates dystonia,
particularly in the areas for planning complex motor movements called the motor cortex, the pre-
motor area, and the supplemental motor areas. Other structures such as the basal ganglia and the
cerebellum help coordinate movements, and none is part of the autonomic central nervous
system. Id.
        Dr. Lancaster distinguished dystonia from dysautonomia. Id. at 610. Dystonia is a very
complex motor problem emanating from the brain that does not involve the autonomic nervous
system in any substantial way. Dysautonomia involves failure of other autonomic functions but
does not involve dystonia. Id. Dr. Lancaster discussed the Suarez paper (Ex. 132), whose senior
author is Dr. Philip Low, an esteemed expert on autonomic disorders. The paper discusses
idiopathic autonomic neuropathies without any known cause. Id. at 610-11. Dystonia is not
included in the paper. Id. at 611. The paper does discuss the symptoms of autoimmune
autonomic neuropathy that Dr. Lancaster mentioned in his testimony: pseudomotor testing
(sweating) and adrenergic function testing (blood pressure, cardiovascular functions). But the
authors do not discuss dystonia. Id.
        Dr. Lancaster defined myasthenia gravis as a disorder of acquired muscle weakness
occurring insidiously over weeks to months. Id. The pattern of the weakness in myasthenia
often centers on the muscles of the face, neck, and eyes with some involvement of the neck and
shoulder girdle, but very little involvement with the smaller muscles in the hands, feet, and legs.
Id. at 611-12. Some of the more characteristic aspects of patients with myasthenia gravis is that
the muscles keeping their eyes open are weak, resulting in ptosis. Id. at 612. In addition, many
myasthenia patients have weakness of the muscles moving the eyes. They frequently complain
that they see two images because their eyes are not aligned any more. Nystagmus would be
uncommon. Id. Nystagmus is a repetitive beating movement of the eyes. Id. at 613. In all of
petitioner’s medical records, Dr. Lancaster testified that he did not see any description of
petitioner having ocular weakness. People with myasthenia gravis become objectively weak
with repeated muscle use. Id. People with myasthenia gravis become weaker toward the

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evening. Id. at 614. Myasthenia gravis does not fluctuate second to second or minute to minute,
Dr. Lancaster said. People with myasthenia develop respiratory weakness because the phrenic
nerve is not transmitting well to the diaphragm’s neuromuscular junction and the diaphragm
becomes weak. As myasthenia patients lose respiratory strength, they go into myasthenia crisis.
Id. They become weaker over several weeks or days and each breath is labored and short. Id. at
614-15. These patients are incredibly ill and in danger of imminent death. Id. at 615. They need
to go to the hospital and often to go on a ventilator. That crisis does not rapidly turn on and off
from minute to minute and second to second. They can be gradually brought out of crisis over a
course of days to a couple of weeks. Id.
       The undersigned asked Dr. Lancaster about petitioner’s episode of stridor during the
hearing the day before and his medical analysis of what he saw and heard. Id. at 615-16. He
responded:
                 I heard the loud stridors kind of breathing sound. Clearly there
                 was a component of stress triggering a physical illness, which is
                 exactly what we’ve been talking about here. There could well be
                 some underlying physiologic contribution to the stridor as well.
                 For instance, she could have gastric reflux coming back up and
                 irritating the vocal cords, and then she just in the setting of the
                 stress, that was enough to push her over the edge. She could, as far
                 as I know, have allergies or some other problem with her larynx
                 that I would have no way of knowing about that until they do a full
                 evaluation. I did not think I saw any stigmata of myasthenia at that
                 time whatsoever. It’s particularly notable that Dr. Steinman, who
                 was close to her, kept pointing out that she’s moving air well,
                 which is the main problem with myasthenia gravis is your
                 diaphragm is weak and you can’t move air well. What she was
                 doing probably required something like five or ten times as much
                 respiratory effort as a normal person would have at rest, and so we
                 observed her doing that. You could hear the very loud quality of
                 the sound. So, I don’t think that that was myasthenia gravis.
                 There was stridor.
Id. at 616-17.
        Dr. Lancaster said the normal treatment for stridor would be epinephrine to activate the
sympathetic system which reduces airway inflammation. Id. at 617-18. He would probably not
use Mestinon as the first treatment for stridor because it causes drooling and diarrhea. Id. at 618.
But Dr. Lancaster stated Mestinon might have an “incredibly powerful placebo effect” if
petitioner thinks that it would help her. Id. Dr. Lancaster said that if he were in the ER, he
would not be sure what he would do and might well just give her what she thinks would help her
for the placebo effect. Id.

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        Dr. Lancaster recalled that petitioner also went to the hospital for stridor in November
2013 when her dog and cat were fighting. Id. at 619. (Subsequent to the hearing, once petitioner
filed the Medstar Georgetown University Hospital records, Dr. Gee told the Georgetown doctors
that petitioner had numerous visits to hospital emergency rooms for stridor.) Dr. Lancaster said
that he did not observe petitioner have an increased effort of breathing or respiratory distress the
day before. Id. at 621.
        Dr. Lancaster said her running an 8K race is completely inconsistent with having
significant symptoms of myasthenia gravis. Her very rapid fluctuations and reports of weakness
are not myasthenia. When she reported that her tongue was vocally paralyzed, that was not
myasthenia. The nature of her voice and her sound during the videos when she made
exaggerated increased movements in her face when speaking is the opposite of what a
myasthenia patient would do. Id. At times, petitioner would whisper and, at other times, she
would speak very loudly. Id. at 622. When Dr. Lancaster saw that on video, it did not look like
actual myasthenic shortness of breath.
        Dr. Lancaster explained that myasthenia gravis is a disorder of the neuromuscular
junction, particularly of the post-synaptic neuromuscular junction. In order to move, a nerve cell
that comes from your brain or your spinal cord (the central nervous system) has to go out and tell
a muscle to contract by releasing acetylcholine on the muscle in a specific area called the
synapse. Id. The muscle cell has acetylcholine receptors to pick up the signal and those
receptors will trigger the electrical signal to the muscle. Id. at 623. If someone has an antibody
to those proteins that are on the muscle at the acetylcholine receptors, that makes the connection
unreliable. Then, the muscle fails and the person becomes weak. He noted that an antibody to
the acetylcholine receptor in the post-synaptic membrane is a completely different disease than
an antibody to nerve on the pre-synaptic membrane, which is Lambert-Eaton Syndrome. Id. Dr.
Lancaster said he agreed completely with Dr. Steinman that petitioner does not have Lambert-
Eaton Syndrome. Id. at 624. Dr. Lancaster said that myasthenia gravis is not some sort of
vaguely defined autoimmunity to the autonomic nervous system or even to the somatic (non-
autonomic) nervous system. Myasthenia involves patients with antibodies to specific proteins on
muscle cells at the neuromuscular junction. Id.
        Dr. Lancaster said that petitioner’s allegations would encompass autoimmunity all over
the nervous system, without objective evidence of damage on MRIs, EEGs, and lumbar
punctures. Id. at 625. He explained this is why he is strongly of the opinion that petitioner does
not have an organic etiology for her symptoms. Id. at 626. He said:
               If the symptoms were very brief, confined to one specific area,
               then sure, easier to come up with an organic etiology, but
               prolonged over a long period of time, so many different areas, so
               severe, that’s what makes it impossible.
Id. Because petitioner did not have acetylcholine receptor antibodies and MuSK antibodies, and
she had negative results of repetitive stimulation studies (she was tested twice before and after
IVIG), Dr. Lancaster opined it is far more likely that petitioner does not have myasthenia gravis.

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Id. at 626, 627. He noted that myasthenia gravis does not impact cognition. Id. at 627. He also
noted that patients with myasthenia gravis do not have tremors. Id. at 628. He said that is
actually unusual, particularly since large amplitude, violent tremors take a lot of energy. Violent
tremors or shaking is not part of myasthenia gravis. He does not know of any evidence that flu
vaccine causes myasthenia gravis. Id.
        Dr. Lancaster then discussed the videos filed into evidence. Id. at 631. Respondent’s
counsel showed Exhibit AAA which was a 20/20 news story broadcast in July 2010 but showing
footage from the time period of the fall of 2009 after petitioner received flu vaccine on August
23, 2009. Dr. Lancaster said one of the most prominent symptoms was language which was
variable on the video. She appeared to sound Australian but then more like an English person.
There was a period where she had severe stuttering. She seemed to use her facial muscles
excessively while talking. Id. In addition, she had unusual movements when she was running.
Id. at 632. She seemed to have great difficulty walking forward, but could walk backward or
sideways, and she could run forward. Dr. Lancaster termed this astasia-abasia. Petitioner was
deeply bent and shaking her body quite violently, keeping her feet on a narrow basis, one close
to and in front of the other, rather than widening out her gait, yet she did not fall. Id.
        The video also showed petitioner running for almost an hour without lightheadedness or
the inability to maintain her blood pressure. The video showed petitioner reporting numbness.
She also reported cognitive difficulties such as not thinking clearly and not being able to access
her memories despite no obvious physical manifestations at that moment. The video showed her
having several kinds of tremors. She appeared to have a shaking event with decreased
responsiveness. She reported respiratory distress but did not appear on the video to be in
respiratory distress. Dr. Lancaster said he had never seen a distressed myasthenic patient look
like that. Id.
         Dr. Lancaster found it very interesting that petitioner reported reading about the fact that
some patients could run and not walk. Id. at 633. She read about them walking backward but
not forward, and then she would go and experiment, and each time it worked. Dr. Lancaster
stated, “I believe in that case each of these was an example of suggestion.” Id. He explained
that it worked for her because she thought it should or might work. He said the videos show this
power of suggestion in other situations, i.e., the infusions, the chelation, the hyperbaric oxygen
therapy, the drops on her forearms. Id. Dr. Lancaster stated, “When someone with a disease like
conversion disorder thinks that something is going to work, it’s very likely to work.” Id. at 633-
34. This is unlike myasthenia gravis where no matter how many suggestions a doctor might
make, it will not make any significant difference in the patient’s symptoms. Id. at 634.
         The undersigned asked Dr. Lancaster if he saw on the videos dystonia or dysautonomia
and he replied in the negative. He thought it interesting that petitioner referred to sensory tricks,
i.e., touching her chin or jaw if she had vocal dystonia, or putting a little stimulus on her neck if
she had neck dystonia. He said, “Here, again, I noticed that each of these things can occur in
some patients, she goes and reads about it, and in short order it happens.” Id. Dr. Lancaster
stated it would be very unusual for patient to have this many different types of dystonia all at

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once in which all the tricks worked perfectly, and which seem to come and go depending on
what other things she was doing during the video. Id. at 634-35.
        Dr. Lancaster said that petitioner’s seeming to be barely able to breathe when she arrived
at Dr. Buttar’s clinic on October 18, 2009 was extremely unlikely. Id. at 635. As for petitioner’s
stuttering, compared to someone with myasthenia gravis, Dr. Lancaster said stuttering comes
from the brain not from the neuromuscular junction. Id. at 635-36. Similarly, an accent comes
from the brain. Id. at 636. Language is a learned process. Sometimes a brain injury, e.g., a
stroke, causes someone to shift from one accent to another. More common is someone who grew
up speaking a different language and switches to another language might, after a stroke, have
relatively preserved parts of his brain that could still speak the original language but not the
second language. Id. Dr. Lancaster never saw on video that petitioner had facial weakness,
another distinguishing feature in myasthenia patients. Id. at 637.
      Dr. Lancaster noted that petitioner on other videos complained of abnormal movements
when she moved her tongue. He said that would be very uncommon for an organic disease.
Moving the tongue would not trigger a seizure-like event if petitioner had a seizure disorder. Id.
        Dr. Lancaster explained that if the autonomic nervous system is objectively impaired, it
cannot function, and sensory tricks would not work. Id. at 638. He defined astasia-abasia as the
characteristic gait of many psychogenic movement disorders. Id. at 639. The patient puts one
foot in front of the other, bending and lurching wildly, reporting a feeling of incredible
unbalance and incredible instability, yet does not actually lose balance. It is very distinctive
because if someone has a problem with his or her nerves or all his or her muscles, as in
peripheral neuropathy, he or she cannot feel his or her feet well. The natural response would be
to stand up straight, widen out his or her gait, and move slowly with no extra movements. If a
patient with a nerve or muscle disorder tried to walk as someone with astasia-abasis does, that
person would fall flat on his or her face. When someone bends his or her knees deeply and puts
one foot right in front of the other, that effort requires the most strength, energy, and balance. Id.
       With reference to petitioner’s inappropriate episodes of uncontrollable laughter, Dr.
Lancaster said that the autonomic nervous system does not control laughter. Id. at 640. He
added that inappropriate episodes of uncontrollable laughter would not be a symptom of
dysautonomia, myasthenia gravis, or dystonia. Id. Identifying areas of the nervous system that
could be invoked in petitioner’s case if she had an organic problem, Dr. Lancaster said that
shakings and tremor concern motor control pathways; stuttering concerns central motor control
pathways; and trouble walking concerns motor pathways in the brain through the spinal cord,
sensory motor fibers in the legs and muscles, and the neuromuscular junction. Id. at 641.
Trouble concentrating is not attributable to the autonomic nervous system either. Id. at 642.
        If petitioner did have damage to all these nervous systems, he would expect abnormal
brain MRI, lumbar puncture, and other studies. Damage affecting many areas of the nervous
system should leave objective evidence showing up on examinations. Id. Dr. Lancaster said that
petitioner does not have any objective evidence of damage to her nervous system. Id. at 643.

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         Dr. Lancaster discussed the difference between someone with a dystonic gait and
someone with astasia-abasia. Someone with a dystonic gait develops it gradually. Typically, his
or her leg will have abnormally increased muscle tone extended at the knee and extending and
turning in at the ankle. It looks somewhat like the gait of someone who had a stroke affecting a
leg. It is fixed and stays the same for years. It looks the same when the person walks. The
person with a dystonic gait does not lurch or shake. Someone with a dystonic gait might have
trouble walking forward, but she would also not be able to walk backward. Id. Astasia-abasia,
on the other hand, involves a wild gait with deeply bent knees and wild lurching movements,
giving the appearance that the person is incredibly off-balance without falling. Id. at 644. If the
person does fall, he or she tends to fall on a couch, on a bed, or where people can catch him or
her. Astasia-abasia varies a lot from moment to moment. It is distractible. It comes and goes. It
is inconsistent. Id.
        Besides the lack of objective proof of petitioner’s having an organic reason for her
symptoms, i.e., normal brain MRIs, normal lumbar puncture, she had a number of neurologists
who examined her very carefully, such as Dr. Urrutia and Dr. Yan-Go. Id. at 645. Petitioner did
not have stigmata of a neurologic injury. Id. at 646. If she had a brain injury, she should have
had spasticity, abnormal changes in muscle tone, abnormalities in reflexes, abnormalities in
pupillary function, fixed language deficits, and fixed problems. Her EEG in late 2009 was
normal. All her brain CT scans and brain MRIs were normal. Id. All her cardiologic
examinations, including EKG and stress echo on December 21, 2009, were normal. Id. at 647.
Petitioner appeared to pass out at the end of her stress echo, which Dr. Lancaster interprets as
another manifestation of her conversion disorder since her test results were normal and they did
not document any hypotension during the study. Id. at 648. The cardiologist Dr. Tanenbaum
found that petitioner’s heart had a regular rhythm, normal cardiac sounds except for a low-grade
murmur, with a blood pressure of 110/70 supine and 102/70 sitting, both of which are normal.
Id. at 649-50. There was no objective evidence of autonomic neuropathy. The stress echo
results of normal heart rate and normal blood pressure mediate against a diagnosis of autonomic
disorder involving cardiovascular function. Id. at 650. Dr. Lancaster explained Dr.
Tanenbaum’s notation of neurocardiogenic syncope as a generic term for someone who appeared
to pass out. Id. at 651.
        Dr. Lancaster said that during petitioner’s first three hospitalizations in September 2009
(twice at Inova Loudon and once at Inova Fairfax), when she complained of syncope or near
syncope, the hospitals checked her orthostatic status and found nothing clinically significant. Dr.
Lancaster did not see any objective testing revealing petitioner had significantly abnormal blood
pressure or heart rate during the four months post-vaccination on August 23, 2009. Id. He
explains petitioner’s complaints as a result of conversion disorder. Id. at 652.
        Dr. Jonathan Bresner, a neurologist at Inova Fairfax during petitioner’s hospitalization
from September 26-29, 2009, noted petitioner’s tremulousness and abnormal body movements.
Id. at 652-53. Dr. Lancaster commented that Dr. Bresner thought they were peculiar and
difficult to characterize neurologically and regarded petitioner’s neurologic exam as normal. Id.
at 653. Dr. Bresner noted that he originally asked to see petitioner to check whether she had

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GBS and decided she did not. He considered she might have a psychogenic etiology for her
symptoms. Dr. Bresner thought petitioner might benefit from psychological counseling or
psychiatric evaluation. Id. The discharge diagnosis was malaise and fatigue, abnormal
involuntary movement not otherwise specified and lack of coordination, other malaise and
fatigue, conversion disorder, obstructive sleep apnea, and stuttering. Id. at 653-54.
        The discharge summary notes:
              At the time of presentation, the patient was noted to have very odd
              neurological symptoms with difficulty walking and tremors during
              evaluation of strength. However, patient’s reflexes were normal
              and no other focal findings could be identified.
Id. at 654. The notes continue that Dr. Bresner suspected petitioner’s neurological symptoms
were not consistent with GBS and there could be a psychogenic component to her symptoms. Id.
at 654-55. The records also note that petitioner was unable to hold a cup of water in her hand
without spilling the water, but she was able to put makeup on fully in the morning during the
hospitalization, including eyeliner, without complication until the nursing staff confronted her,
after which she could no longer do this task. Id. at 655. The doctors did repeat testing of ANA
and a phospholipid antibody panel. The doctor spoke to petitioner’s personal care physician Dr.
Kelly Rodriguez who did not see clear evidence of an obvious organic etiology, seemed
concerned about a psychogenic etiology, and agreed with petitioner’s having a psychiatric
evaluation. Id.
       Dr. Lancaster remarked that it is clear that many different physicians came to the same
conclusion of a diagnosis of conversion disorder. Id. at 655-67.
        Dr. Lancaster then turned to petitioner’s visit to Johns Hopkins Hospital on October 2,
2009. Id. at 658. Petitioner was referred for an evaluation of GBS. Id. at 659. Petitioner
reported bilateral lower leg weakness that progressed to the upper legs, increasing difficulty
speaking and walking, and shortness of breath. Id. Petitioner had normal strength, sensation,
and reflexes. Id. at 660. These were careful examinations to determine whether she had
peripheral neuropathy and there was no evidence of it. Moreover, they did a lumbar puncture to
rule out elevated protein. There was no GBS. Id.
      Dr. Lancaster with reference to Dr. Steinman’s thesis that there is a purely autonomic
GBS said:
              I don’t believe that anyone could make the diagnosis of a purely
              autonomic GBS. I don’t believe that’s an accepted medical illness,
              so I don’t think we should rely on GBS or anything like that to
              explain her symptoms. [T]here’s nothing about this case that
              makes any sense for GBS.
Id. at 661.

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        Dr. Lancaster said that Dr. Urrutia, the neurologist at Johns Hopkins, is a skilled
neurologist who observed petitioner when she had her most active motor symptoms. Id. at 662.
Dr. Urrutia did not find any objective deficits on petitioner’s neurological examination. He
observed that her symptoms clearly had a strong psychogenic component and he seemed to be
working toward a diagnosis of conversion disorder. Dr. Urrutia wrote this note on October 3,
2009. Id. At a later time, Dr. Urrutia came by and noticed that petitioner felt better, having been
given Ativan. Id. at 662-63. Petitioner had no focal deficits and was able to get off the bed
walking normally backward or sideways, but not forward. Id. at 663. A physical therapist
mentioned dystonia. Petitioner continued to stutter on examination but talked normally if she
whispered. When she walked forward, she buckled and seemed jerky, but did not fall or hurt
herself. She managed to turn around and sit on the bed. Dr. Urrutia’s assessment was that her
symptoms did not fit a physiologic paradigm and he thought she might be having a reaction to
anxiety. Id.
        Dr. Lancaster found it very interesting to see a neurologist who got to see things that
were probably very similar to what Dr. Lancaster sees in his practice and what Dr. Lancaster
observed in petitioner’s videos reach the same conclusion he has. Id. at 663-64. Dr. Lancaster
thinks significant Dr. Urrutia’s description of petitioner’s wild lurches in astasia-abasia, but she
catches herself without injury. Id. at 664. Patients with organic disorders of gait unsteadiness
fall down a lot and get hurt a lot. Id. Dr. Lancaster noted that even though the physical therapist
at Johns Hopkins opined petitioner might have dystonia, none of the physicians at Johns Hopkins
diagnosed petitioner with dystonia. Id. at 665. Dr. Lancaster agrees from his viewing of
petitioner’s videos that she did not have dystonia, and the treating neurologists’ opinions are a
helpful supporting factor. Id.
        Dr. Lancaster reviewed petitioner’s personal care physician Dr. Ho’s records and noted
that Dr. Ho did not independently assess and diagnose petitioner with dystonia. Id. at 669. Dr.
Ho listed dystonia in his records because petitioner gave him a history that a physical therapist
had told her this at Johns Hopkins. Dr. Ho recommended further workups which, if they proved
unavailing, he would strongly consider a conversion disorder, delusional disorder, or other
psychogenic etiology. Id. Even if petitioner were diagnosed with dystonia, Dr. Lancaster said
that would not mean she had dysautonomia because dystonia and dysautonomia are very
different. Id. at 670-71. Dr. Ho prescribed Valium, a benzodiazepine, used for anxiety among
other reasons for petitioner. Id. at 671. Johns Hopkins had discharged petitioner on
Clonazepam, which is another benzodiazepine, 0.25mg. Petitioner said she took the first dose
and had convulsions afterward. She tried one-half dose the day before the visit to Dr. Ho, which
was better, but she noted that when she took one of her then-husband’s 5mg doses of Valium,
she was “perfectly normal” for about 10 hours. Id. Petitioner said she tried some Ativan, which
knocked her out. Id. She told Dr. Ho she planned to see a dystonia specialist at the Mayo Clinic
in November 2009. Id. at 671-72.
       Dr. Lancaster said he does not know how to provide a physiological mechanism to
explain how taking a benzodiazepine would rapidly produce convulsions. Tr. at 672. He stated
doctors use benzodiazepine to treat seizures. Benzodiazepines produce increased inhibition in

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the brain. Dr. Lancaster strongly suspected that petitioner’s convulsions were the same kind of
event all her videos portrayed. He noted that benzodiazepines can be used to treat anxiety and
that someone with conversion disorder would transiently feel somewhat better after taking a
benzodiazepine or, in petitioner’s case, with any other drug where there was a suggestion it
might work. Id.
        Dr. Lancaster noted petitioner’s visit to Dr. Randolph Stephenson, a neurologist, on
December 7, 2009, during which Dr. Stephenson gave petitioner a thorough examination which
was completely normal. Id. at 673. However, when he asked petitioner to point or write
something, she would start shaking quite vigorously as would her hands. Id. at 673-74.
Petitioner’s tremor was in several planes of direction and highly distractible. Id. at 674. It also
had a highly suggestible component to it. Dr. Stephenson could easily bring her out of a tremor
by having petitioner talk about it. Dr. Stephenson also recognized petitioner’s gait was very
clearly astasia-abasia. Petitioner would often appear off-balance, but she actually had better
balance than the average person given her body position when she was walking. Dr. Lancaster’s
opinion was that Dr. Stephenson’s record shows that petitioner’s tremors were suggestible and
distractible, meaning they were psychogenic. Id. A patient with psychogenic tremor who is
suddenly distracted tends not to maintain the tremor. Id. at 675. Dr. Lancaster also noted that
the fact petitioner’s tremor was in multiple different directions and planes is very unusual for an
organic tremor. Organic tremors tend to be very consistent. Id.
        Dr. Lancaster commented that Dr. Stephenson’s description of petitioner’s gait was
excellent, entirely consistent with astasia-abasia, and exactly what Dr. Lancaster saw in
petitioner’s videos. Id. at 676. He said that Dr. Stephenson’s conclusion was that there was a
very clear functional component to the majority of petitioner’s physical examination. Id. at 676-
77. “Functional component” means psychological component. Id. at 677.
        Respondent’s counsel then played Exhibit GGG, a video of Inside Edition, which aired
on October 16, 2009. Id. at 678. Dr. Lancaster noted that petitioner’s gait did not represent true
classic dystonia. From the video, Dr. Lancaster said petitioner does not appear to have any fixed
dystonic postures in any of her limbs. She has rather wild-flowing movements. She had deep
bending of her knees and balancing. He remarked how much sheer energy it would take to do
her gait. Id. He does not believe it is dystonic. Id. at 679. He would call it psychogenic
dystonic. Dr. Lancaster also said that petitioner’s gait and movements are not consistent with
autonomic failure. He stated someone with autonomic failure has nothing directly wrong with
the motor control of his or her legs and arms. The problem is with maintaining blood pressure.
The person might get a little lightheaded, need to sit down and rest, but would not have anything
like what petitioner manifested in the video from autonomic failure. Dr. Lancaster was
impressed with petitioner’s good autonomic cardiovascular control to behave as she did in the
video. She did not report she was getting dizzy or needed to sit down or that she passed out. She
did not have autonomic failure. Id.
       Dr. Lancaster also did not think the symptoms petitioner depicted in the video supported
a diagnosis of myasthenia gravis. Id. He called attention to her harsh speech and how much her
face moved when she was trying to talk, while she was obviously moving very well considering

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how much she was exerting herself. Id. at 680. Dr. Lancaster said myasthenia gravis does not
get better with exercise. Myasthenia gravis gets worse with exercise. Id.
        Although petitioner testified about weakness, Dr. Lancaster said he did not see any
convincing evidence of weakness in the video and the other videos he saw. She seemed to be
doing remarkably well in many aspects of strength. Being able to run on a narrow base with her
knees deeply bent while jerking her arms takes a lot of strength. He does not believe she had
muscle weakness in the video, and her physical examinations showed she had good strength in
many muscle groups. Id. Dr. Lancaster stated the video is consistent with conversion disorder
but not organic disease. Id. at 681.
        Dr. Lancaster agreed that petitioner had rhabdomyolysis. She recovered from it in about
two weeks. Her rhabdomyolysis was relatively mild. Id. Dr. Lancaster believes the cause of
petitioner’s rhabdomyolysis was a viral infection. Id. at 682. She was coughing up green
phlegm on multiple occasions, had a sore throat day after day and subjective fevers. Exercise
can be a very strong contributing factor to rhabdomyolysis. Petitioner was training for a race and
she would probably have been fine if she did not have a cold. Muscle enzymes tend to rise with
any significant strenuous exertion and superimposing a cold can lead to rhabdomyolysis. Id. Dr.
Lancaster explained that rhabdomyolysis is a breakdown in muscle fibers from a muscle injury.
Id. at 583. Typical causes are infection, overexertion or overuse, excessive heat, and severe
metabolic derangements. Rhabdomyolysis reflects transient damage to the muscle. Id. The
number one cause for rhabdomyolysis is infection and overexertion. Id. at 684.
        Dr. Lancaster said it would be extremely unlikely for an autonomic nervous system
problem to cause rhabdomyolysis. He stated the autonomic nervous system does not directly
control skeletal muscle and could not make skeletal muscle break down. He remarked that nerve
injuries of any sort tend not to cause rhabdomyolysis because the muscle is fine. Patients with
GBS generally do not have a significant elevation in their creatine kinase (CK). Id. Creatine
kinase is a muscle enzyme. Id. at 685. It is a useful marker for muscle injury. Too much protein
in the blood from a damaged muscle could damage the kidneys. Id.
        Dr. Lancaster testified that petitioner’s rhabdomyolysis was a self-limited event and mild.
Id. at 686. Petitioner’s other symptoms have nothing to do with rhabdomyolysis. Id.
         Dr. Lancaster then spoke about the Hallett article on psychogenic movement disorders
(Ex. ZZ). Id. at 687. The first clue is movements may be inconsistent over time. This is
something that both Dr. Stephenson and Dr. Lancaster noticed, the former during his physical
examination and the latter while watching petitioner’s videos. Tremors might come and go and
be variable in frequency. The movements may sometimes be difficult to classify and may be
mixtures of disorders such as myoclonus (rapid muscle jerks), chorea (dance-like movements)
and dystonia. The movements might be so unusual as to be classified as bizarre. Movements
might disappear with distraction or be precipitated by suggestion. Other features of psychogenic
movement disorders are give-away weakness, which means inconsistent effort when a doctor is
testing a patient’s strength. Id. A patient who does not have an organic disease will often have a
brief strong effort and then the limb will give way suddenly. Id. at 688.

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        Hallett also mentions psychogenic gait which is characterized by unusual patterns of
stance and gait often inconsistent, often dramatic with lurching, but only rarely results in falls
and then the patient does not hurt himself or herself. Sudden knee buckling without falling is a
common pattern. Dr. Lancaster thinks the Hallett article is a good description of what he has
seen in this case, i.e., a great variability in the types of tremors, the characteristics of tremors, the
types of speech problems, the types of movement problems in general, and the gait where
petitioner almost falls and does not hurt herself. This is all an excellent fit. Id.
        Respondent’s counsel then played the next video, Trial Exhibit 58-1, which is dated
October 17, 2009, and depicts petitioner preparing for a race, her dysarthria is getting better, she
walks backward to start the race, and starts the race jerking a little but soon her running turns
into a normal run and she speaks normally while running an 8K race. Tr. at 689. Dr. Lancaster
says that petitioner’s presentation was inconsistent with autonomic dysfunction because there
was no indication that she had trouble maintaining her blood pressure as she was running, she
was talking quite clearly, and she did not report feeling lightheaded, dizzy, or weak. Dr.
Lancaster stated that petitioner’s presentation in this video is also inconsistent with dystonia. Id.
Petitioner has a psychogenic movement disorder with a lot of lurching and apparent instability,
but not real instability, and then she gets better. Id. at 689-90. Dr. Lancaster found novel the
idea that vocal dystonia would improve when petitioner was running. Id. at 690. He is not
aware that anyone has ever reported that for dystonia. Petitioner’s presentation in the video is
inconsistent with myasthenia gravis. Someone with myasthenia gravis would rapidly fatigue and
need to stop running as he or she attempted to run. His or her speech would not improve while
running. He or she would be short of breath and start gasping. Id. Dr. Lancaster did not see any
weakness in this video. Id. at 691. Dr. Lancaster said that petitioner’s presentation in the video
was inconsistent with petitioner’s having any organic neurologic condition. Id. Conversion
disorder is a diagnosis doctors use when the symptoms have a psychiatric rather than a
neurologic basis. Id. at 692.
        Dr. Lancaster testified it would be extremely unlikely for someone with active
myasthenia to run an 8K race. Id. at 693. He said that petitioner’s presentation of symptoms in
this video is inconsistent with an autoimmune etiology because autoimmune damage to the
nervous system does not come and go this quickly. Id. at 694. Autoimmune diseases do not
suddenly turn on and turn off.
        Respondent’s counsel then played the next video, Trial Exhibit 58-3, which is an
interview after the 8K race on October 17, 2009. Id. Dr. Lancaster describes the video as
showing petitioner sitting at the end of the race, describing how when she stops running, her
abnormal movements return. It does not sound like cardiovascular collapse. Petitioner’s
breathing appears very steady and effortless. Her face has a strong expression. She does not
have any evidence of ptosis, i.e., drooping of the eyelids. She appears to move her tongue
normally when she talks. Dr. Lancaster said he never sees a focal paralysis of the tongue in
myasthenia gravis. He could not think of any organic etiology for focal tongue paralysis. It is
another symptom of conversion disorder. Id.

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        Respondent’s counsel then played the next video, Trial Exhibit 58-4, also dated October
17, 2009, which shows petitioner walking backward slowly into a house while manifesting
abnormal speech. Id. at 695-96. Dr. Lancaster stated petitioner walks backward as she did
before, but before when she walked backward, she did that normally and effortlessly. Id. at 696.
In this video, she walks backward stomping each time she takes a step backward. She lifts each
leg high and stomps it down while leaning forward as she walks backward. Dr. Lancaster said it
takes more strength and balance to walk backward upstairs than it does to walk forward or even
forward up a staircase. This increases the amount of work and balance petitioner did by a couple
of factors, arguing more against her having dystonia. Id. Dr. Lancaster said this video does not
have anything to justify a diagnosis of either dysautonomia or myasthenia gravis. Id. at 697.
Instead, it supports the diagnosis of conversion disorder. Id.
         Respondent’s counsel then played the next three videos, Trial Exhibits 58-5, 58-7, and
58-8, all dated October 17, 2009. Id. at 697-98. Trial Exhibit 58-5 depicts petitioner drinking
water and eating food very quickly at a table, swallowing very well. Then she immediately
drops her head and is assisted to a couch where she lies on her side and continues to eat while
having “seizures.” Then she starts having a lollipop. She says it was hard to breathe and then
starts crying. Trial Exhibit 58-7 depicts petitioner lying on a couch, eating strawberries. Her
then-husband holds her head down so she can continue to eat strawberries. Trial Exhibit 58-8
depicts petitioner’s then-husband holding her forehead and chin while feeding her blueberries.
Petitioner finished the whole bowl and has a “seizure” after moving her tongue. Her speech is
slow and slurred.
        Dr. Lancaster said that the tremors appearing in the videos are not dystonic because the
pattern of complex shaking of multiple areas of petitioner’s body progressing over time is
inconsistent with dystonia. Tr. at 698. He stated dystonia tends to be relatively localized to
certain muscles or groups of muscles. Id. at 698-99. He said that petitioner’s convulsive-like
event is not what dystonia looks like and is a psychogenic event. Id. at 699. An epileptic seizure
causes patients to lose consciousness. Id. When petitioner was shaking in all four limbs but still
wide awake, manipulating things with her arms, and responding to what other people were doing
or saying to her, that is inconsistent with an epileptic seizure. Id. at 700. Where in petitioner’s
brain would this seizure have to be? It would have to be in the right hemisphere to make the left
side of her body and head jerk. Id.
        In addition, 90 percent of the time, people who have epileptic seizures open their eyes in
the direction away from the hemisphere driving the seizure. Id. at 700-01. Only a small subset
of people having an epileptic seizure have their eyes closed. Id. at 701. But petitioner at many
points closed her eyes while she was shaking. Her limbs were shaking while she used her left
hand to feed herself strawberries. Dr. Lancaster said this makes no sense. The videos show
petitioner eating during a seizure that was affecting her neck and head muscles so that her head
was jerking. Anyone who tried to eat during a seizure would most likely inhale the food into his
or her lungs and would aspirate and choke. But the videos show how well petitioner ate multiple
times. This is very consistent with a psychogenic seizure. Id.

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        Another very important factor is petitioner’s idea that protruding her tongue caused her to
seize. Id. Dr. Lancaster said this makes no sense because protruding the tongue does not cause
epileptic seizures. Id. at 702. However, anything that the patient thinks can trigger a seizure can
trigger a psychogenic seizure. Dr. Lancaster thought it interesting how well petitioner could
stick out her tongue. When petitioner talked, her tongue often appeared paralyzed, but at other
times, petitioner sticks out her tongue.
        Dr. Lancaster noted petitioner was breathing very well. He said petitioner’s swallowing
and breathing functions were excellent. This is inconsistent with myasthenia gravis. Myasthenia
gravis patients have trouble swallowing and if they attempted drinking a whole glass of water,
they would choke. Myasthenia patients do not have shaking spells like this either. Similarly,
autonomic dysfunction is not the cause of her symptoms. In autonomic dysfunction, the
voluntary parts of swallowing are basically fine. Id.
        The videos do not show a blood pressure drop or syncope even when petitioner is lying
flat on her back. Id. at 703. Yet she is having all these complex movements. If she were
passing out, she would not be feeding herself strawberries. Nothing about the video depicts
myasthenia gravis or autonomic failure. If you showed 100 neurologists this video, a high
percentage would say petitioner is having a non-epileptic seizure and no one would diagnose
myasthenia gravis, autonomic failure, or dystonia. Id.
         Dr. Lancaster said the videos show petitioner had really excellent use of her chewing
muscles. Id. at 704. She very rapidly and strongly chewed her food. She swallowed both water
and solid food without difficulty. Her jaw muscles were not weak. Id. Petitioner’s presentation
in this video is inconsistent with any known organic neurological condition. Id. at 705.
         Respondent’s counsel then played the next video, Trial Exhibit 58-12, dated October 18,
2009, which shows an interview continuing. Id. Petitioner’s speech flows more than before.
She does not show physical impediment and uses her hands while talking. Then she slows down
and starts singing “Mary had a Little Lamb” but then transitions to a mini seizure that does not
last long. Petitioner goes out of head bopping and hand curling to talk to the interviewer again.
Then she stands to demonstrate that she does not feel lightheaded standing, but only when she
starts trying to move.
        Dr. Lancaster says that petitioner is discussing how moving her tongue triggers seizure-
like events. She has a vocal problem which continues to fluctuate under different circumstances.
Here, she is speaking in a very strong, loud voice with good movements of her face. But she
often has a harsh tone in her voice that seems to go away instantly when she touches her jaw.
Then when she sings, the movement returns with shaking of the head. Id. Her arm movements
are good and normal. Id. at 706. Petitioner’s presentation in this video is not consistent with
dysautonomia, dystonia, and myasthenia gravis. She has excellent strength in her face as she is
moving, her eyelids do not droop, and she does not have respiratory distress. Someone with
myasthenia gravis who tries to sing will get worse because you have to move more air and use
your vocal apparatus more to sing than to speak. Id. Patients with myasthenia gravis give up

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singing (referring to Ex. WW, at 3). Id. at 708. Dr. Lancaster said that petitioner’s presentation
in the video is inconsistent with any known organic neurologic condition. Id. at 709.
        Respondent’s counsel then played the next two videos, Exhibit AAA and Trial Exhibit
58-20. Id. at 710. Exhibit AAA is the 20/20 broadcast of clips of petitioner stumbling and
struggling to walk, and clips of an interview of petitioner and her then-husband in which
petitioner speaks in a British accent. Then there is an analysis of whether she is faking it or not.
There are clips of an interview with Dr. Buttar defending his treatments and allegations he is a
fraud. Experts state petitioner does not have dystonia and that whatever she has is not caused by
flu vaccine. Clips comment on her Internet fame and petitioner comments that there is no way
she is faking it because she would have to be an amazing actress to do this. Other experts in the
clips believe it is psychogenic. Trial Exhibit 58-20, dated October 18, 2009, shows petitioner
and her then-husband sitting on a couch using a laptop together. Petitioner has the laptop on her
lap with earphones in. Petitioner has slurred speech. She is reading e-mails from people
contacting her regarding her condition including doctors and sympathizers. Petitioner says it is
hard to read, but she types on her laptop well.
        Dr. Lancaster notes that petitioner’s speech pattern changed again in that it was starting
and stopping with a staccato quality. He noticed petitioner seemed to be using her computer
without difficulty. She and her then-husband seem to be learning about Dr. Buttar’s clinic. Id.
Petitioner mentions that some patient received detoxification treatment, saying “her got detox.”
Id. at 711. To Dr. Lancaster, this indicates not only trouble pronouncing, but also an abnormal
word choice. Petitioner complained about her eyes jerking or it was difficult for her to read.
That would require an explanation for what happened to her ocular pathways, which Dr.
Lancaster said he has yet to hear. None of petitioner’s medical records, including neurologists’
notes and other doctors’ notes, say there is anything objectively wrong with petitioner’s visual
system either in her eye movements or in terms of her visual acuity. To give petitioner an
organic etiology for her symptoms would require giving her “a pile of different diseases that are
located in many different areas of the nervous system.” Id.
         Dr. Lancaster stated that petitioner’s symptoms have been fluctuating and changing the
entire time, depending on the situation and what she is doing. Id. at 712. Sometimes she has a
lot of tremors in her arms. Other times, her arms are fine. Sometimes, she has a neck tremor.
Other times she does not have a neck tremor. Sometimes her speech problem is foreign accent
syndrome where she speaks clearly but with a British accent. Other times, her speech is harsh
and strained. Still other times, her speech is slow and halting. Throughout these videos,
petitioner’s symptoms are constantly different.
         The autonomic nervous system does not process the muscles that allow one’s eyes to
move from side to side. Those muscles are under voluntary control. Similarly, the perception of
light is not considered part of the neurologic problem. The only part of the autonomic nervous
system relating to vision is the generation of sufficient tears. If that fails, someone would get
terribly dry eyes or dilated or constricted pupils. Id. Petitioner has been examined multiple
times with no evidence of any defect. Id. at 713.

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        Dr. Lancaster said that dystonia, dysautonomia, and myasthenia gravis are not relevant to
her gait problems, speech problems, perception problems, abnormal feeling of hot and cold
(sensory symptoms), language problems, and problems thinking what word she is going to say.
Id.
        Respondent’s counsel then asked about petitioner’s treatment at Dr. Buttar’s clinic. Dr.
Lancaster described chelation as using a chelator, a substance for binding heavy metals, on a
patient who is actually exposed to heavy metals. Id. at 714. Chelators are chemicals which in
high enough doses to work are quite dangerous and potentially toxic. Dr. Lancaster called them
serious substances. He does not know what dose Dr. Buttar used on petitioner. Id.
        Dr. Buttar had two chelators. Id. at 716. Dr. Lancaster said, “the idea that you could get
enough of these things to be physiologically effective by putting the drops on your arms is
ridiculous.” Id. The little drops would not make any difference at all.
        In addition, Dr. Buttar put petitioner in a hyperbaric chamber with pressurized air, but not
hyperbaric oxygen. Id. Petitioner received several IVs, the exact contents of which are unclear.
Id. at 717. Most importantly, Dr. Lancaster said, Dr. Buttar repeatedly suggested to petitioner
that she would respond to different treatments and recover. He said the DMPS drops (another
chelator) have no validity or use. Id. The lollipop (Vitapop) that petitioner was sucking in a
video with vitamin B12 would have no effect on a person who was not vitamin B12 deficient.
Id. at 718. The idea that someone could suck on a vitamin B12 lollipop and have an
instantaneous effect is the placebo effect. Id. Dr. Lancaster said petitioner did not have mercury
poisoning. Id. at 719. She was never exposed to any sufficient source of mercury to cause her
symptoms unless she ate one or two thermometers which she never reported. The amount of
mercury and the type of mercury in vaccines is completely harmless. Dr. Buttar said he was
chelating petitioner because of ethyl mercury in flu vaccine. Id.
        Dr. Lancaster remembered one treatment at Dr. Buttar’s clinic purportedly to remove
blood from one of petitioner’s arms and return it to the other arm after passing it through a
machine. Id. at 720. Dr. Buttar was going to blast the blood with ultraviolet light to kill
whatever infection petitioner might have. Id. Dr. Lancaster said he had no idea what this
machine actually did. Id. at 720-21. It did not correspond to any accepted medical treatment for
infection of which he is aware. Id. at 721. It sounded hazardous to Dr. Lancaster in that it could
introduce a blood clot by destroying petitioner’s blood cells. It could create a sepsis response.
He could not imagine it helping with any infection. Dr. Lancaster said that sitting in a
pressurized air cubicle would be very unlikely helpful and he agreed with Dr. Steinman that the
accepted medical use of hyperbaric chambers is primarily for treating diving injuries. It also can
potentially accelerate wound healing. Id. He has never used it for an autoimmune disease. Id. at
722. Dr. Lancaster believes Dr. Buttar’s diagnosis is completely incorrect and he would not have
given any of those treatments for whatever diagnosis petitioner had. Id.
       Respondent’s counsel then played the next video, Trial Exhibit 58-35, dated October 20,
2009. Id. Dr. Lancaster described the video as depicting petitioner undergoing treatment in the
hyperbaric oxygen chamber. Id. at 723. Stan Kurtz says this is the first time he has heard

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petitioner speak in a normal tone of voice. Petitioner’s symptoms have gone away. She is eating
normally, with excellent use of her hand to control the fork and no difficulty with coordination.
She can now stick out her tongue and wag it around without it triggering symptoms or abnormal
movements. Petitioner appears not to have respiratory distress or weakness of breathing. She
swallows her food perfectly. Id. She does not vomit. Id. at 724. Before then, petitioner was
speaking abnormally. Dr. Lancaster said that hyperbaric treatment is not effective for dystonia,
autoimmune encephalitis, autonomic disorders, myasthenia gravis, or any other known
autoimmune disease. Id. Dr. Lancaster said petitioner’s response to the hyperbaric treatment in
this video is not consistent with an autoimmune condition. Id. at 724-25.
        Dr. Lancaster explained that autoimmune conditions involve either antibodies that bind to
specific targets and nerves, i.e., neuromuscular junction in myasthenia gravis, autonomic ganglia
in autoimmune autonomic neuropathy. Id. at 725. They use complement and other mechanisms
to cause lasting damage at those locations. If someone could use a magic wand to dispel
instantly antibodies completely from someone with an autoimmune disease, such as myasthenia
gravis, it would take days to weeks for the neuromuscular junctions to be repaired from the
damage the antibodies did. Someone with autoimmune autonomic neuropathy would take days,
weeks, or months to recover from an elimination of all those antibodies. Patients with
autoimmune encephalitis have antibodies affecting the brain causing long-lasting changes in ion
channels. That would take days, weeks, or months to become totally better as well. Id. The idea
that an antibody-mediated disease would instantly resolve from any mechanism makes no sense.
Id. at 726.
        Dr. Lancaster said that if we are talking about cytotoxic T-cells damaging other cells,
there is even more lasting damage which will not get better instantly even if one could make the
T-cells immediately disappear. Improvement would take days, weeks, or months of recovery.
Dr. Lancaster stated petitioner’s very rapid recovery in the video between profound disability
and being totally fine mediates very strongly against her having any autoimmune neurologic
disorder in his experience. He thinks the reason petitioner improved with chamber therapy was
the placebo effect because of the very strong suggestion that she would improve. One can hear
in the video that petitioner was being told how these things would work over and over. Id. In a
psychogenic illness, suggestion is powerful. Id. at 727. The following colloquy took place:
              THE COURT: I take it the basis of your testimony that she
              doesn’t have what she alleges she has, dysautonomia, dystonia,
              myasthenia gravis, is not only that the symptoms that you’re
              familiar with from the medical records do not match those
              illnesses, but that she also recovered instantaneously with this fake
              treatment?
              THE WITNESS: That is exactly my point. And that’s not
              consistent with any of these diseases. There is nothing that I can
              conceive of that would make those diseases instantly get better.
Id.

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        Respondent’s counsel then played the next video, Trial Exhibit 58-46. Id. at 728. This
video deals with petitioner’s assertion that she had cold spots in her head. Dr. Lancaster said that
myasthenia gravis would not cause cold spots or abnormal cold sensation in her head because
myasthenia gravis is a motor problem not a sensory problem. Id. He would not associate cold
spots with dystonia or any autonomic symptoms either. Id. at 728-29. Dr. Lancaster thinks
petitioner is reporting sensory symptoms for which an organic basis has not been established. Id.
at 729. Petitioner was trying to make sense of her symptoms through the idea Dr. Buttar gave
her of mercury coming out of her body. Id. at 730. Dr. Lancaster’s best explanation is the power
of suggestion. Dr. Lancaster noted that the video showed petitioner awake, alert, speaking
normally and clearly, and using her face normally. Id.
        Respondent’s counsel then played the next video, Trial Exhibit 58-50. Id. at 731. This
shows petitioner walking forward, backward, and sideways, telling her then-husband she feels
good and talking on a cellphone coherently and loudly. Dr. Lancaster states petitioner’s speech
function, facial movements, limb movements, gait, and balance have completely resolved with
her treatment at Dr. Buttar’s clinic, which is very rapid. Id. Dr. Lancaster said that various IV
fluids and glutathione, which is an antioxidant, would be highly unlikely to have had any
physiologic effect on the alleged diseases. Id. at 732. This is another factor favoring
psychogenic etiology. Id.
        Respondent’s counsel then played three videos, Trial Exhibits 58-59, 58-60, and 58-61,
all dated October 21, 2009. Id. at 732-33. Petitioner is lying on a couch, feeling unwell,
struggling to speak. Dr. Buttar arrives at the hotel with DMPS transdermal drops which he
applies to petitioner’s arms. Petitioner lying on the couch speaks and says her tongue is coming
back and her speech starts to improve. They tell her it was the mercury. She says her lungs are
burning and it will cause a seizure. She indicates the side of her mouth is burning and her speech
becomes slurred again. Dr. Buttar is getting ready to give her more drops, saying petitioner is so
toxic that it is phasing fast. Petitioner says it is moving to the back of her head and her speech is
comprehensible again. Dr. Buttar puts more drops on her arms and she rubs the drops in herself.
In the middle of petitioner’s rubbing, her speech worsens suddenly and is a raspy moan. Then
within a minute, her speech becomes normal again. She talks about the path the burning
sensation is traveling and how it differs with each dose. Dr. Buttar offers to have petitioner and
her then-husband stay at his home if the drops do not help.
        Dr. Lancaster described these DMPS drops as chelator drops. Id. at 733. He notes how
Dr. Buttar repeatedly suggested that they would work. Dr. Buttar also told her that she had
mercury toxicity and that mercury was being removed from her body and was moving through
her body. Id. Dr. Lancaster said several things were not plausible. Id. at 734. Someone with
mercury toxicity cannot feel it moving throughout his or her body. Mercury would not affect
how someone feels in an MRI. Mercury would not heat up and, if it did, it would be so evenly
distributed throughout someone’s body that someone would not notice it. The idea that a
chelator would get into someone’s body and move mercury around which would somehow cure a
patient of any neurologic disease is completely implausible, said Dr. Lancaster. Dr. Buttar told
petitioner all sorts of things happening to her body and she developed symptoms corresponding

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to the story he told her about mercury coming out of her body. He told her the drops would work
and they did through the placebo effect. The videos show petitioner moving her arms, at first
slowly and clumsily, and then just fine after the application of more drops. Id.
        Dr. Lancaster said that petitioner’s speech problems, always a little different, manifested
as a very slow voice that would taper off and slow down until she stopped talking. Id. at 734-35.
At times, petitioner had a harsh croaking sound and then she would rapidly return to her normal
voice at different points of the treatment. None of this is biologically plausible. Id.
        Dr. Lancaster said that autonomic failure would not cause that kind of speech problem
and would not respond to the placebo effect. Id. at 736. Myasthenia gravis does not cause that
sort of speech problem and would not respond on and off very quickly like that to anything. But
conversion disorder frequently would respond to suggestions and placebo effects. Dr. Lancaster
said that what petitioner is manifesting does not make medical sense, in other words, is not
logical as an organic illness. Id.
         Respondent’s counsel then played the next video, Trial Exhibit 58-62, dated October 22,
2009. Id. at 739. Petitioner is eating on a couch, using utensils and speaking normally.
Petitioner says she got tired and had a good night because she could fall asleep. She felt great.
Dr. Lancaster’s observation was that petitioner appeared perfectly well. She was clearly feeling
fine, sitting up, and eating. She did not have any problem chewing, swallowing, or digesting (no
vomiting). Id. Petitioner mentions a seizure that moving her eyes or reading triggered. Id. at
740. Dr. Lancaster said that unusual triggers fit within the paradigm of psychogenic, non-
epileptic events. He did not see any symptom in the video of dystonia or myasthenia gravis. Id.
        Respondent’s counsel then played the next video, Trial Exhibit 58-63, dated October 22,
2009. Id. at 741. It depicts petitioner in a car with her head bobbing that moving her tongue
induced. Dr. Lancaster stated petitioner had some neck thrusting movements. He said this
would be extremely atypical for dystonia and even more atypical for dystonia is petitioner’s
claim she could trigger the neck thrusting movements by moving her tongue. On top of that,
petitioner claims her tongue is numb, which autonomic failure, myasthenia gravis, or dystonia
would not cause. There is no organic explanation for this. Id. The idea that someone could
move his or her tongue and then have involuntary head thrusting does not correspond to any
neurologic disease Dr. Lancaster knows. Id. at 742.
        Respondent’s counsel then played the next video, Trial Exhibit 58-65, dated October 22,
2009. Id. Petitioner has finished eating while receiving an IV. She does not have the electrical
device on her neck. She first speaks normally, but then pauses, is quiet, and starts whispering.
Then she seems to have a seizure. Her head bobs and her speech is slurred. In less than one
minute, she can speak normally. Then petitioner switches back and forth within seconds
between normal and slurred speech. Id. Dr. Lancaster stated the video shows petitioner’s
abnormal head thrusting and changes in her voice fluctuating very rapidly, turning on and off.
She does touch her chin, which is her understanding of a sensory trick working for dystonia. Id.
at 743. Dr. Lancaster said that cervical dystonia does not look like that. Cervical dystonia
involves a forced turn and/or tilt of the head to one side. It tends to be relatively fixed and is

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very uncomfortable. Torticollis is a form of cervical dystonia. Petitioner’s repeated head
thrusting is not cervical dystonia. She read something about sensory tricks and that they are
supposed to work. Id. This is one of the many factors that support Dr. Lancaster’s diagnosis of
conversion disorder. Id. at 744. Petitioner was told she had arsenic poisoning and uranium
poisoning which he finds implausible. Id. Dr. Lancaster testified that the video does not show
any evidence of actual autonomic disease. Id. at 744-45. Nothing about the autonomic nervous
system would explain what petitioner manifests in this video. Tr. at 745.
        Dr. Lancaster said that a patient with myasthenia gravis could have a head drop, which
looks very different than petitioner’s thrusting of her head. Head drop is gradual so that the chin
rests on the chest or near it and it takes more effort to bring the head up. Id.
        Respondent’s counsel then played the next video, Trial Exhibit 58-66. Id. at 746.
Petitioner is sitting in her treatment chair, talking coherently, and shaking a bottle of transdermal
DMPS drops, saying “This stuff saved my life.” She says she used to have 20-25 seizures daily
and it stopped when a drop of transdermal DMPS was on her skin. Dr. Lancaster says this is
additional confirmation that the treatment had a very powerful placebo effect on her symptoms.
Id.
        Respondent’s counsel then played the next video, Exhibit DDD, dated October 29, 2009.
Id. at 747. This video shows petitioner receiving IV treatment at Dr. Buttar’s office, thanking
people and wanting to let people know that she was getting better. She speaks normally. The
video was going to a website where she posted status updates of her health. Dr. Lancaster
comments petitioner reports feeling quite well, she is sitting upright, and she is talking and
thinking clearly and logically. Id. at 748. She does not have any evidence of weakness of the
muscles of her face. Her breathing is relaxed and at a normal rate. She appears well. There is
no evidence that she has dysautonomia, dystonia, or myasthenia gravis. Id.
        Respondent’s counsel then played the next video, Exhibit JJJ, which is a Fox 5 news clip
that aired on November 19, 2009, but the date Fox filmed it is unknown. Id. It details
petitioner’s progress in Dr. Buttar’s office. Her voice changes whenever she talks about the time
period when she believes her injury occurred, which Dr. Lancaster states is implausible for
dystonia to appear instantly and result in a slowing of speech, much less that saying a particular
word, such as the date something happened, would trigger dystonia. Id. at 749. He also said that
myasthenia gravis would not suddenly come on and impair someone’s speech as the person said
a particular word. He said it was a ridiculous concept. Dr. Lancaster stated that the idea that
autoimmune autonomic neuropathy would change as someone says a word affecting his or her
speech is “ridiculous squared. It’s so absurd I don’t even know how to explain how illogical it
is.” Id. The reason for petitioner’s sudden speech symptom to come on when she mentioned a
date is psychogenic. She knew it was stressful to talk about. Id.
       Dr. Lancaster stated that the idea that remembering something would trigger vocal
dystonia is incorrect and not logical. Id. at 750. The idea that a memory would affect
myasthenia gravis is illogical. The idea that a memory would affect an autonomic system
disorder such as autoimmune autonomic neuropathy is completely implausible. These are

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problems with how ganglia are working in the sympathetic and parasympathetic nervous
systems. They do not care what one’s memories are. It makes no medical sense. Id.
        In recapping his analysis of all petitioner’s videos, Dr. Lancaster said petitioner did not
have epileptic seizures. Id. at 751. Her tremors were psychogenic, resembling seizures. Id.
From October 17 through October 22, 2009, the videos did not show any evidence of petitioner
having respiratory distress or breathing problems. Id. at 751-52. He did not see her lose
consciousness. Id. at 752. She had episodes he would describe as non-epileptic seizures where
her consciousness appeared to be altered, although she would partially respond during those
events. Someone with an autoimmune disorder would not respond rapidly to treatments that Dr.
Buttar administered. Id. Her symptoms fluctuated: seizure-like events, abnormal movements
involving gait, apparent alterations in her level of consciousness, abnormal tremors in the limbs,
and abnormal positive and negative sensations such as feeling cold spots moving around her
body, or feelings of heat in the MRI. Id. at 752-53.
         All of these cannot be localized to any one part of the nervous system. Id. at 753. She
responded strongly to suggestion about what would happen. The overall nature of the events was
consistent with psychogenic movement disorder, astasia-abasia, psychogenic seizure-like
activities, and psychogenic tumors. There is only one logical conclusion, i.e., petitioner had
conversion disorder fed by repeated suggestions about the sort of disease process she was
thought to have, such as mercury poisoning, and fed by what thoughts she had about her
responses to treatment which Dr. Buttar and other people gave her. Id.
        Dr. Lancaster disagrees with petitioner’s neurologist Dr. Cintron’s assessment that
petitioner had a vaccination-induced motor disorder because there is no diagnostic test to support
that conclusion. Id. at 755. Dr. Lancaster believes from the videos that petitioner had a couple
of dramatically different gait fluctuations. Id. at 757. Dr. Cintron would not have seen these
inconsistencies because he did not view the videos. Id.
        Although Dr. Cintron recommended plasmapheresis and IVIG treatment, Dr. Lancaster
does not agree with those recommendations. Id. at 757-58. Dr. Cintron did not go forward with
those recommendations. Id. at 758. Dr. Lancaster stated that Dr. Cintron did not mention the
autonomic nervous system at all in his notes. He mentioned a motor disorder. Id. A motor
disorder involves voluntary movement, very different from a disorder of the autonomic nervous
system. Id. at 759.
        When petitioner was at the Inova Loudoun Hospital ED on September 17, 2009, Dr.
Dulai, a neurologist, did a physical examination and found petitioner did not have significant
weakness. Id. at 761-62. This is inconsistent with myasthenia gravis. Id. at 762. Her eye
movements and eyelids were basically intact. Id. Dr. Dulai’s examination results are not
consistent with dysautonomia. Id. at 763. Her vital signs were normal. Id.
        Dr. Lancaster testified that from August 23, 2009, when she received flu vaccine, through
the end of 2009, petitioner did not have autoimmune failure or myasthenia gravis. Id. at 764. In
that period of time, she did not have dystonia unless it is described as psychogenic dystonia. Id.
at 766. She had conversion disorder. Id.

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        On the fourth day of the hearing, Dr. Lancaster resumed his direct testimony. Id. at 773.
Respondent asked Dr. Lancaster if an article marked as Exhibit 176 was relevant to petitioner.
That is the Raj article on blood volume in POTS. The authors state that patients with POTS have
chronic symptoms lasting at least six months, consisting of rapid palpitation, exercise
intolerance, lightheadedness, extreme fatigue, and mental clouding. They have an increase in
heart rate of at least 30 beats/min within 5 to 30 minutes of assuming an upright posture which
should occur in the absence of orthostatic hypotension, i.e., a fall in blood pressure >20/10 mm
Hg. The authors also state many patients with POTS have low blood volume. The authors
theorize that abnormalities in the renin-angiotensin-aldosterone axis may play a role in the
pathophysiology of POTS by contributing to hypovolemia, perhaps by impaired sodium
retention. They trace perturbations in the renin-aldosterone system to partial sympathetic
denervation involving the kidney, an explanation consistent with the partial dysautonomia
hypothesis for some patients with POTS. The recommendation to increase salt in the diet and
intake of water is commonly made for POTS patients.
        Dr. Lancaster said the Raj article does not explain what happened with petitioner. Tr. at
774. The basic idea of the article is that patients with POTS have a mild degree of
cardiovascular autonomic dysregulation for reasons not entirely known. It is a syndrome but not
a disease. Id. He agrees with Dr. Steinman that giving a patient with POTS IV fluid for a long
period of time lessens POTS symptoms. Id. at 775. Feeling better would only deal with
lightheadedness and dizziness. It would not deal with foreign accent syndrome, complex
movements, and numbness. In Dr. Buttar’s office, petitioner did not really seem to have any
symptoms consistent with POTS and she had numerous symptoms that POTS would not explain.
Id.
        Dr. Lancaster said that someone with POTS might feel a little tremulous or shaky when
standing up and need to sit down. Id. at 776. But the violent tremors petitioner exhibited were
not indicative of POTS. Psychogenic seizures are not related to POTS either. IV fluids would
not help them physiologically. But someone could have a placebo effect through receiving IV
fluids which could likely work with psychogenic seizures. Id.
        Dr. Lancaster stated it was extremely unlikely that petitioner had POTS when she was
receiving treatment at Dr. Buttar’s clinic. POTS could not plausibly account for the symptoms
appearing on the videos. Dr. Lancaster does not believe petitioner ever had POTS. Id. The
numerous times when petitioner had various tests and maneuvers, she developed numerous
symptoms without having characteristic blood pressure changes or pulse changes one might
expect with POTS, particularly the pulse changes. Id. at 776-77.
        Moving beyond 2009 into 2010, respondent’s counsel showed a video, Exhibit BBB,
which is a segment of Inside Edition, aired February 4, 2010, depicting an encounter between the
Inside Edition reporter and petitioner in a parking lot in January 2010. Id. at 777. The show is
an update following petitioner and showing clips of her walking normally and driving. The
reporter walked up to her and she told him she had recovered but not completely because she
was speaking with an Australian accent. Petitioner insisted that her illness was not psychogenic.
At the end of the interview, as she approaches her parked car, she walks sideways.

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        Dr. Lancaster found significant the clip of petitioner walking very normally without any
sign of a movement disorder as she comes out of a store before meeting the reporter. Id. at 778.
She speaks loudly and very clearly with what appears to be an Australian accent. After she
finishes talking to the reporter, she walks sideways to get to her parked car. She also reported
cognitive issues, but she was driving at the time and did not show any signs that Dr. Lancaster
could observe of cognitive issues. Dr. Lancaster stated these observations are consistent with the
overall picture of a psychogenic etiology. Petitioner did not have any symptoms until she
encountered the reporter, a stressful situation, and he asked her uncomfortable questions,
resulting in the recurrence of her symptoms such as the foreign accent. Id. Nothing in this video
would support a diagnosis of dystonia, dysautonomia, POTS, or myasthenia gravis. Id. at 779.
        Even though petitioner testified that her foreign accent was due to her inability to
pronounce words, Dr. Lancaster said she pronounced words very well. He thinks many people
speaking with an Australian accent would sound exactly like petitioner did. Dr. Lancaster stated
in his career, he has heard many patients with different types of dysarthria, but their dysarthria
did not make them sound like that. “Dysarthria” means difficulty pronouncing words without
any impairment in thought content or language content. The words do not come out clearly as if
someone had a bunch of marbles in his or her mouth. Id. Someone with a nerve injury that
paralyzed his or her tongue would have dysarthria. Id. at 780. Someone with a stroke that
weakened facial and mouth muscles could have dysarthria. An injury to the cerebellum would
affect coordination of motor movements can cause dysarthria. Id. Petitioner sounded as if she
were either Australian or someone trying to speak as an Australian.
       As time moved on from 2010, petitioner’s symptoms changed. Id. at 781. In the early
time period, petitioner’s predominant symptoms were abnormal lurching gait. That faded away
or was much less prominent. Her complaints of seizure-like episodes which were very
prominent then faded away. Complaints of cognitive clouding were initially very prominent but
became much less prominent in subsequent visits. Id.
         Then, reports of gastrointestinal or autonomic problems came on. In the beginning, she
had trouble eating. Id. But she would say she had trouble when she moved her tongue because it
triggered seizure-like events or abnormal neck movements or other symptoms. Id. at 782. At
times, she said her tongue was numb or paralyzed. These were troubles of voluntary eating. But
her initial reports would not have indicated gastroparesis where someone eats and vomits
subsequently. Those symptoms emerged later, i.e., inability to keep food down after swallowing
it. Dr. Lancaster distinguished between everything post-vaccination in 2009 and what petitioner
complained of in 2010. Id.
        In 2009, as petitioner described in the videos, she reported that movement of her tongue
triggered abnormal thrusting movements of her head or sometimes seizure-like spells. This is
the reason she gave for having trouble eating. Later, she did not connect her symptoms to tongue
movement, but to her not keeping food down. Id. at 783. Petitioner saw Dr. Patrick D. Lyden, a
neurologist, on January 10, 2012 for an evaluation of dysautonomia and spells. Id. at 784.
Petitioner told him she developed POTS after a flu vaccination in 2009. Id. at 784-85. Petitioner
gave a history of muscle weakness, fatigue, exercise intolerance, tachycardia, and postprandial

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hypotension. Id. at 785. Dr. Lancaster stated Dr. Lyden was unaware of petitioner’s lurching
gait and seizure-like spells because petitioner did not tell him. She told him she had exercise
intolerance but did not tell him her profound movement disorder got much better with exercise.
Id. She did not tell him of numbness or tongue movement triggering her symptoms. Id. at 786.
She did not tell him about dystonia. Dr. Lancaster thinks petitioner’s report to Dr. Lyden of a
positive tilt-table test is an oversimplification of what happened during the test. Dr. Lyden’s
view of the case, therefore, is different than if he had seen the videos filed in the case. Id.
        Dr. Lyden stated in his records that the case was very complicated. He thought petitioner
might have severe dysautonomia and a possible diagnosis of migraine. In addition, he thought
petitioner might have an unsuspected psychiatric diagnosis. Id. Petitioner had a trace neurologic
finding localized to the right cerebellum or brainstem given her rotary nystagmus and hypotonia.
Id. at 786-87. He wanted to review her brain MRI scan. Id. at 787. He also planned to have a
transcranial duplex, a vascular study of the blood vessels in the brain to try to recreate the small
vessel disease seen on the SPECT scan. Id.
        On January 13, 2012, Dr. Lyden followed up with additional information. Id. He did a
physical examination and commented that her mental status was again remarkable for a
significant indifference to her medical state. Id. at 787-88. She spoke in a foreign accent for half
the visit. Id. at 788. The foreign accent syndrome resolved spontaneously and she finished her
visit with her midwestern American accent. She did not have any change in her cranial nerve
exam, motor or sensory function or reflexes. He noted that in petitioner’s tilt-table test, she had
an acute onset of dysarthria and dystonic posturing. Multiple brain MRI scans were normal. She
took Norpace for possible dysautonomia from a post-vaccine reaction. No evidence in the record
supported a diagnosis of GBS. No evidence supported the diagnosis of hypotension. However,
there were repeated descriptions of bizarre and unusual symptoms related to postural changes.
Id. She had a significant dystonic and syncopal reaction during a carotid ultrasound. Id. at 789.
        Dr. Lyden’s overall impression was that petitioner’s transcranial doppler study was
essentially normal. Id. He recognized that she embellished her symptoms although she did have
rhabdomyolysis during an episode of dehydration. She had symptoms suggestive of
dysautonomia despite the negative tilt-table test. He thought a good psychologist should
evaluate petitioner. Id. To Dr. Lancaster, Dr. Lyden favored a psychogenic etiology for her
symptoms and he changed his initial impressions once he had additional data. Id. at 790.
        Dr. Lancaster discussed Dr. Yan-Go’s records. Id. He described her as a respected
expert in autonomic neurologic disorders. She performed a careful evaluation looking for
objective evidence of autonomic dysfunction in petitioner. After weighing that evidence, Dr.
Yan-Go concluded petitioner did not have a significant autonomic dysfunction. Id. Dr. Yan-Go
specifically stated that petitioner had a very complex symptomatology, many symptoms of which
she could not explain with a unified disorder. Id. at 791. Dr. Lancaster stated that means Dr.
Yan-Go could not find one explanation for all of petitioner’s symptoms. Dr. Lancaster said Dr.
Yan-Go suspected petitioner had a functional component. “Functional” means psychogenic. Id.

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         On September 14, 2010, Dr. Yan-Go wrote she still thought overall petitioner did not
have any serious pure autonomic failure or degenerative dysautonomia. Id. Dr. Yan-Go wanted
to treat petitioner symptomatically and make sure petitioner did not become deconditioned. Id.
at 792. Dr. Yan-Go wanted to prevent petitioner having subconscious brain patterning that
would affect her and lead to further disability. This was approximately one year after
petitioner’s flu vaccination. Dr. Lancaster mentioned that Dr. Yan-Go is eminently qualified to
detect autonomic dysfunction. Id.
        On August 26, 2010, Dr. Kevin Ghassemi, a gastroenterologist, notes petitioner’s
complaints of vomiting and difficulty swallowing. Id. at 794. He notes petitioner can eat only if
she exercises first. Id. Dr. Lancaster said if petitioner were having effects on the cardiovascular
part of her autonomic nervous system, exercise would make everything worse, not better. Id. at
795. Exercise stresses and uses the cardiovascular autonomic system to maintain one’s blood
pressure. Id. Dr. Lancaster stated that the idea that intense exercise would somehow solve a
gastrointestinal dysautonomia does not make a lot of sense, particularly that petitioner would, as
she told Dr. Ghassemi, have a 24-hour benefit from exercise. Id. at 796. Dr. Ghassemi wrote
that petitioner was unlikely to have a primary gastrointestinal motility disorder. Id. at 797.
         Dr. Ghassemi had petitioner undergo an upper GI series and esophageal manometry, the
first outlining what is going through the digestive tract and the second measuring pressure. Id. at
798. Both studies were basically normal. Dr. Ghassemi deferred to neurologists as to any
neurologic diagnosis of petitioner. As for making a gastrointestinal diagnosis, he concluded she
did not have evidence of esophageal dysmotility. Id.
        On March 30, 2012, petitioner underwent a gastric emptying study. Id. at 799. It showed
markedly prolonged gastric emptying consistent with gastroparesis. Id. at 799-800. This is two
and one-half years post-vaccination. Id. at 800. Dr. Lancaster said there was a major
confounding factor at that time which was petitioner was taking medications, some of which can
interfere with gastric motility, particularly Sandostatin, which is known to prolong gastric
emptying. Dr. Lancaster said Sandostatin could be why petitioner’s stomach emptying was slow.
Id. To Dr. Lancaster, this one test of gastric emptying does not in the overall context of the case
make it probable that petitioner has autonomic failure. Id. at 801. Dr. Lancaster said that
gastroparesis is not itself a disease, but a finding, that might have numerous causes including
medications. Id. at 803.
        Dr. Lancaster’s opinion is that petitioner may have gastroparesis due to medications, but
she did not have gastrointestinal dysautonomic disorder in light of multiple other tests. Id. at
808. Since petitioner’s vaccination was two or three years earlier, Dr. Lancaster does not think
anyone can plausibly link it to the vaccine. Tr. at 809.
       Dr. Lancaster does not believe that petitioner’s gastrointestinal postprandial hypotension
study on October 15, 2010 supports a diagnosis of postprandial hypotension. Id. There were
multiple blood pressure readings from 8:15 to 9:35 a.m. and multiple pulse readings over the
same period of time. Id. at 809-10. The pulse ranged from 98 to 114. Id. at 810. The systolic
blood pressure ranged from 117 to 135 and the diastolic from 77 to 89. All were well within the

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range of normal. He thought it would be interesting to know if petitioner developed any
symptoms at 45 minutes when she experienced an 18-point drop. He said a healthy, athletic
young woman with a blood pressure of 117/82 and a pulse of 108 should be feeling fine. He
thinks it would be a big mistake to regard this drop as evidence of postprandial hypotension as an
explanation for her symptoms. Id.
        Dr. Lancaster stated that Dr. Cintron’s diagnostic impression shifted from 2009 going
into 2010 and beyond. Id. at 814. Initially, Dr. Cintron wrote about dystonia or myoclonic
features, i.e., abnormal postures and jerking. Id. Later, he began to suspect an autonomic
disorder or gastroparesis. Id. at 814-15. Dr. Lancaster does not see convincing evidence of
autonomic dysfunction in Dr. Cintron’s records. Id. at 815. From 2010, Dr. Cintron considered
the diagnosis of dystonia or a dystonic-like illness. Dr. Lancaster disagrees with this diagnosis
based on seeing the videos. Other neurologists did not diagnose petitioner with dystonia. In
2010 and afterward, the symptoms upon which Dr. Cintron relied to diagnose dystonia became
much less prominent. Id.
        Dr. Daniel V. Wilkinson, Jr., a cardiologist, saw petitioner on December 15, 2010 and
took a history from petitioner in which she said she had POTS. Id. at 816. Dr. Lancaster stated
that Dr. Wilkinson did not arrive at the diagnosis of POTS independently. Id. at 817. Dr.
Wilkinson’s note clarifies that petitioner began taking Sandostatin well before she underwent the
gastric emptying test. Id. Dr. Wilkinson notes that petitioner manifested multiple very unusual
symptoms, including changes in her speech and language patterns associated with a presumed
drop in blood pressure. Id. at 818. Dr. Wilkinson notes petitioner’s exercise tolerance is poor.
She told him walking up two flights of stairs will cause her to lose speech and become
presyncopal. Id. She reported episodic chest pain. Id. at 819. This went away with exercise and
she felt best when she exercised vigorously. Dr. Lancaster comments that it makes no sense to
write petitioner had poor exercise tolerance when she said she feels best when exercising
vigorously. Dr. Lancaster thinks this is why Dr. Wilkinson said petitioner’s symptoms were very
unusual. Dr. Lancaster thinks that petitioner’s difficulty in climbing two flights of stairs would
be much worse if she exercised vigorously. It would cause more disabling symptoms. Id. Dr.
Lancaster said it is not easy to explain this with any organic disease of the heart or the neurologic
system for the autonomic nervous system. Id. at 820.
         Dr. Lancaster explained that one of the many factors forming his opinion that autonomic
dysfunction is not the correct diagnosis (and myasthenia gravis would not cause these complaints
either) is that someone with either autonomic dysfunction or myasthenia gravis would get much
worse with exercise. Id.
       Dr. Blair Grubb, on July 9, 2011 evaluated petitioner who told him she had GBS after flu
vaccination and as a reaction to it. Id. at 820-21. She then had extreme hypotension and also
rhabdomyolysis. Id. at 821. Dr. Lancaster said the history petitioner gave Dr. Grubb is not
accurate compared to the contemporaneous medical records. Id. at 822. First, she said that she
was diagnosed with GBS which her treating doctors ruled out. Dr. Lancaster said the diagnosis
of GBS would be important to explain autonomic dysfunction in regulating her blood pressure.
Id. Any doctor would think autonomic dysfunction was a logical result of having GBS. Id. at

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823. Dr. Lancaster noted petitioner was hypertensive at this time with her blood pressure
measuring 148/78. When petitioner stood, her blood pressure did not drop but was 148/84.
Thus, petitioner did not show any evidence of having autonomic failure when she saw Dr.
Grubb. To answer why a healthy, athletic young runner had blood pressure that was too high,
Dr. Lancaster answered she was on Midodrine, a medication used to increase blood pressure in
patients who are suspected of having autonomic failure. Dr. Lancaster said the medicine
probably caused petitioner to be hypertensive. Id.
        Dr. Lancaster disagreed with Dr. Grubb’s assessment of petitioner’s condition as an
autonomic neuropathy due to a vaccine reaction because petitioner gave him incorrect
information. Id. at 824. Moreover, petitioner did not have postural hypotension when she saw
Dr. Grubb. She was hypertensive. Id. Dr. Lancaster noted that petitioner had a markedly
different recollection during her testimony of some of the visits compared to what the doctors
documented. Id. at 826. He said this is extremely common in conversion disorder. Id.
         Dr. Joey Gee worked petitioner up on May 17, 2012 for myasthenia gravis. Id. at 828.
Dr. Gee recorded a myriad of symptoms relating to dysautonomia, weakness, and possible
vasculopathy, and records that petitioner has seen rheumatologists, cardiovascular specialists,
neurologists, cognitive specialists, orthopedists, ophthalmologists, and other specialists. Id. Dr.
Gee notes quite correctly that myasthenia gravis is a neuromuscular junction process and could
account for petitioner’s weakness, but it would not account for cerebral changes with a vasculitis
pattern or for optic neuritis. Id. at 828-29. Dr. Gee considers GBS and chronic inflammatory
demyelinating polyneuropathy (“CIDP”) which could induce and promote weakness and
dysautonomia. Id. at 829. Dr. Gee notes petitioner had never undergone an EMG and plans to
order one for her. This would provide evidence for myasthenia gravis as would doing the
repetitive nerve stimulation test. Id. He also planned to do a test for MuSK antibody and he did
a test for acetylcholine receptor antibody. Id. at 830.
         Dr. Lancaster remarked that petitioner never had optic neuritis. Id. Dr. Lancaster points
out how multifocal the symptoms are about which petitioner complained. Id. at 831. Dr.
Lancaster said petitioner “bombarded” Dr. Gee with a great deal of information which he, to his
credit, tried to decipher. Id. at 832. She also had foreign accent syndrome. She complained of
weakness and foot drop. She gave a history of nystagmus, which means abnormal shaking
movements of the eyes. She said her arms were weak and she had urinary frequency and
dizziness. Dr. Lancaster thinks Dr. Gee was thrown off by the history petitioner gave him of
optic neuritis, which led Dr. Gee to consider neuromyelitis optica and multiple sclerosis. Id. Dr.
Lancaster said:
                 I feel what Dr. Gee is going through here. There was just a tidal
                 wave of information that came in and many things that do not
                 appear to be accurate were given to him.
Id. at 832-33.
        Petitioner gave Dr. Gee a new symptom of post-exertional headaches and a new symptom
of foot drop. Id. at 833. Dr. Lancaster said Dr. Gee did not find an organic basis for these

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symptoms. Dr. Gee considered whether petitioner had vasculitis because that could damage
multiple different parts of the nervous system, causing tiny strokes to different areas of the brain,
spinal cord, and peripheral nerves. The SPECT study would have thrown him off and made him
worry about vasculopathy. Dr. Lancaster said Dr. Gee was understandably thinking about “a ton
of different diseases under this avalanche of information” that petitioner gave him. Id. Dr.
Lancaster said the SPECT study can be inconsistent and not specific to individual neurologic
diagnoses. Id. at 835. The fact that the subsequent PET study was normal makes Dr. Lancaster
consider the SPECT result a false positive. Id.
        Dr. Lancaster said that no doctor diagnosed petitioner with vasculitis and he does not
believe she had vasculitis. Id. at 836. Vasculitis means strokes of different tissues. Brain
vasculitis causes permanent severe brain injuries. Vasculitis of the peripheral nerves generally
causes permanent very severe nerve damage that objective evidence would find. Id.
        The results of the testing Dr. Gee ordered were negative for myasthenia gravis and the
PET study was normal. Id. Dr. Sheean in San Diego tested petitioner a second time for
myasthenia gravis on January 29, 2015. Id. at 837. Dr. Sheean’s testing was to quantify levels
of different antibodies in petitioner’s blood. All the tests were normal. She had normal IgA,
SSA and SSB (which test for lupus-like conditions), and acetylcholine receptor antibody (which
was zero, which is as negative as it could possibly be since normal is less than 45). Id. at 837.
Dr. Lancaster explained there are two different kinds of acetylcholine receptor antibody test.
One is for antibodies that modulate the receptor and the other is for antibodies that block the
receptor. Id. Petitioner was negative for both kinds of acetylcholine receptor antibodies. Id. at
838. Petitioner was tested for voltage-gated calcium channel antibodies which, if the test were
positive, would support a diagnosis of Lambert-Eaton syndrome. That, too, was negative. She
was tested for antibodies to the voltage-gated channel complex, which was negative. Id.
        The undersigned asked Dr. Lancaster why Dr. Sheean diagnosed petitioner with
myasthenia gravis when all her test results were negative, a result that was consistent with the
results of the tests Dr. Gee ordered three years earlier. Id. at 838-39. Dr. Lancaster responded
that he thinks Dr. Sheean was using myasthenia gravis as a working diagnosis, but he was
looking for objective confirmation that his diagnosis was correct. Id. at 839. Petitioner’s
repetitive stimulation studies were done again and were yet again negative. Id. at 840. As all
these tests came back negative, Dr. Lancaster said it was very unlikely that the diagnosis of
myasthenia gravis was correct. Id. at 841.
        Dr. Lancaster thinks if Dr. Sheean had seen petitioner’s videos and Dr. Buttar’s records,
Dr. Sheean might have had a very different impression of how likely it was that petitioner has
myasthenia gravis. Id. Dr. Lancaster wondered if Dr. Sheean would do the one test on petitioner
that he did not do: single fiber test. Id. He said that people with conversion disorder who
receive treatments for illnesses they do not have are being put at risk. Id. at 843. Dr. Lancaster
said he does not have an organic explanation for petitioner’s testifying that when Dr. Sheean
raised the dosage of her IVIG, her myasthenia gravis symptoms got better, but her autoimmune
dysautonomia symptoms got worse. Id. at 844-45.

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        As for Dr. Steinman’s assertion that petitioner’s test results were negative because she
was on IVIG, Dr. Lancaster said the initial tests were done before she went on IVIG. Id. at 846.
He does not think it is true that IVIG would cause a negative result. Id. Dr. Lancaster explained
petitioner’s statement that IVIG helped her symptoms by saying this was the same placebo effect
as her positive responses to Dr. Buttar’s treatments. Id. at 846-47. IVIG is an incredibly
powerful placebo. Id. at 847. What Dr. Lancaster saw in the hearing room on the second day of
trial when petitioner sank to the floor growling was not indicative of a myasthenic crisis. Id.
She also had an episode of stridor when her dog and cat were fighting on November 4, 2013. Id.
at 848.
        Dr. Lancaster remarked that the videos showed petitioner with large flailing movements
of her limbs, raising her arms up and down, which he would not associate with a natural dystonic
posture of the limb which usually involves a forcible contraction and fixed flexion of the hands.
Id. at 853. Patients with organic dystonia probably have a genetic etiology and not an
autoimmune etiology in Marsden’s article (Ex. 170). Id. For the patients in Marsden’s article,
the dystonia came on gradually and persisted for years, remaining the same. Id. at 853-54. The
patients did not have rapid fluctuation among different symptoms. Id. at 854. They did not have
associated symptoms of seizure-like events, passing out, feeling events were triggered by their
tongue, feeling cold spots, and feeling profound weakness. Dr. Lancaster, in comparing
petitioner with the subjects of Marsden’s article, called them as different as night and day. Id.
        In the Fahn article (Ex. 129), the subjects had dystonia and used sensory tricks. Id. The
patients often developed deformities in the neck from having their neck twisted in one direction
over a prolonged and sustained contraction. Id. at 855. Fahn is describing torsion dystonia, a
twisting of part of the body, particularly the neck. Mostly the cause is genetic or idiopathic, not
considered to be autoimmune. Id. Dr. Lancaster noted that most of petitioner’s doctors who
observed the prominent movements of her gait, such as Dr. Urrutia, thought it was non-
physiologic. Id. at 856. Dr. Lancaster does not think petitioner had any autoimmune neurologic
injury in proximity to her flu vaccination. Id. He does not think petitioner had autoimmune
autonomic ganglionopathy. Id. at 857. He stated, “I do not believe she had any organic disease
induced by vaccination.” Id. at 858.
      Dr. Lancaster took issue with Dr. Steinman’s thesis that there is molecular mimicry
between flu virus and myelin proteins, eliciting nervous system inflammation leading to
autoimmune dysautonomia. Id. at 858, 859. Dr. Lancaster stated:
               Myelin is ubiquitously expressed in myelinated fibers of the
               nervous system. The idea of a selective attack against a myelin
               antigen in such a way as to only damage the autonomic parts of the
               nervous system without damaging the myelin to the arms and legs,
               while … also ignoring … myelin in the optic nerve, in the brain,
               that’s very unlikely. I don’t believe any disease like that has been
               shown to exist.

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                 And, so, one of the things about this case is we’re not just saying
                 that the vaccine caused Petitioner to get some well-established
                 disease, such as Guillain-Barre syndrome. . . . [Petitioner] has a
                 novel disease process that’s not an accepted neurological disease. .
                 . . [T]here is no precedent for it.
Tr. at 859.
       He continued:
                 In the case of myasthenia gravis, we are talking about a disease
                 that we all agree absolutely exists and whether or not she has it.
                 When we’re talking about whether or not she has an autoimmune
                 disease selective to myelin of pre-ganglionic fibers in the
                 autonomic nervous system only, then I don’t know what disease
                 we’re even talking about. It’s not like we can consult a large
                 literature on that disease and what its diagnostic criteria are,
                 because there isn’t one.
                 So, that’s a very different thing from debating whether someone
                 has or doesn’t have a known disease, as we’re discussing a novel
                 disease.
Id. at 860-61.
       Dr. Lancaster’s testimony prompted questions from the undersigned and the following
colloquy took place:
                 THE COURT: All right. Tell me, because this is the first time
                 I’ve heard this kind of comment, is what Dr. Steinman has been
                 identifying with various terms as an autonomic autoimmune
                 neuropathy, does that disease entity not exist?
                 THE WITNESS. No. So, the disease entity of autoimmune
                 autonomic ganglionopathy, autoimmune autonomic neuropathy
                 exists. [T]he one mechanism that’s been established for
                 approximately half of those patients is autoantibodies to the
                 ganglion acetylcholine receptor. Absolutely exists. I don’t think
                 Petitioner had it. [B]ut this idea that at times has been mentioned
                 as a potential disease mechanism of autoimmunity selectively to
                 myelin in the autonomic nervous system, I don’t know what
                 disease that is.
                 THE COURT: So, not only does the physiologic description not
                 make sense, but the disease that would manifest if it existed,
                 doesn’t exist?

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                 THE WITNESS: Well, it’s never been shown to exist as a disease
                 mechanism, in any person. So, it’s one thing to say that someone
                 has a vaccine causing Guillain-Barre syndrome. [He or she] had
                 demyelination of [his or her] autonomic nervous system along with
                 other things. I’m not aware of any evidence, for instance, in
                 patients with autoimmune autonomic neuropathy that has anything
                 to do with demyelination of the autonomic nervous system. That’s
                 an idea. I’m not aware of any patient where that’s been proven to
                 be the case in that sort of selective autonomic neuropathy. The
                 ones that we understand well are autoantibodies to ganglionic
                 acetylcholine receptors, which is a different thing. [I]t’s analogous
                 to myasthenia gravis. …
                 THE COURT: [I]f you don’t have GBS and you don’t have CIDP
                 and all you’re asserting is you have autonomic symptoms which
                 are somehow autoimmune because there’s myelin in autonomic
                 nerves, that just doesn’t exist by itself?
                 THE WITNESS: As far as I know, that has not been shown to
                 exist.
Id. at 861-63.
        Dr. Lancaster said that autoimmunity to myelin in the brain would cause multiple
sclerosis and acute disseminated encephalomyelitis. Id. at 864. Autoimmunity to peripheral
nerves causes GBS or CIDP. Id. Myelin proteins have not been implicated in the
pathophysiology of autoimmune autonomic neuropathy. Id. at 866. Dr. Lancaster testified that
there is no logical or scientific connection of myelin proteins and the pathophysiology of
dystonia. Myelin proteins have not been implicated in the pathophysiology of myasthenia gravis
either. Id.
         All these illnesses have different loci. Id. at 867. Myasthenia gravis localizes to the
neuromuscular junctions on skeletal muscle cells to particular proteins on those skeletal muscle
cells in the neuromuscular junction that are used to receive signals or organize receptors.
Autoimmune autonomic neuropathy involves the sympathetic and parasympathetic parts of the
peripheral nervous system. Dystonia comes from the brain. Petitioner has many other symptoms
that cannot be explained by all these diseases. Dr. Lancaster said Dr. Steinman has not provided
a reliable explanation for flu vaccine causing petitioner this constellation of symptoms. Id.
        Dr. Lancaster said that if we were going to attribute petitioner’s illness to flu vaccine, we
need a plausible explanation of what was wrong with petitioner’s gait and her speech, and why
she was having seizure-like episodes, cold spots, abnormal sensations, tongue paralysis and
numerous other symptoms. Id. at 868. He said, “We cannot just ignore her symptoms and
decide to explain other symptoms that became much more prominent later because that’s more
easy to explain.” Id.

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       Dr. Lancaster thinks infection superimposed on exercise is perfectly reasonable and the
most likely explanation for petitioner’s rhabdomyolysis. Id. There is a clear, contemporaneous
record of petitioner having cold-like symptoms, sore throat, subjective fevers, and green phlegm
to assume she had a cold at the time. Id. at 869.
       (Because respondent’s other expert, Dr. Whitton, had a plane to catch, the undersigned
took his direct and cross examinations before Dr. Lancaster’s cross examination. But for the sake
of consistency, the undersigned summarizes Dr. Lancaster’s cross examination first below.)
        On cross-examination, Dr. Lancaster said this case was the third or fourth one in which
he testified. Id. at 994. He has testified in any kind of court 12 or 13 times. In his practice, he
has made the diagnosis in 100 patients of some form of conversion disorder over a 13-year
period. Id. at 998. For neurology in general, that’s very typical. For someone who works in
epilepsy, that would be a huge underestimation. Id. It would also be a huge underestimation for
someone who works in movement disorders. Id. at 999. Dr. Lancaster’s own clinic focuses on
autoimmune encephalitis for which there is abundant evidence of organic disease. That is why
the number of patients with conversion disorder is lower. Id. Dr. Lancaster said petitioner’s
rhabdomyolysis was relatively mild and short-lived. Id. at 1024. It was essentially gone by the
time she had her most severe symptoms when she went to Dr. Buttar’s clinic. At that time, Dr.
Lancaster did not observe any signs of physiological illness. Petitioner was in great physical
condition, running an 8K race in a pretty good time, performing multiple highly strenuous gaits
which are on the videos, and numerous activities requiring good overall physical health to
perform that astasia-abasia gait. Dr. Lancaster did not observe any physiologic illness that
triggered what was occurring. Id. Dr. Lancaster said he does not know of any evidence for
rhabdomyolysis causing conversion disorder, particularly when it is self-limited and already
over. Id. at 1025.
        Dr. Lancaster said cold-like syndromes are caused by hundreds if not thousands of
different viruses and families of viruses. Id. at 1029. He said there is no comprehensive viral
test panel that can exclude a viral infection. Id. Petitioner on September 18, 2009 had
tachycardia in the context of shortness of breath, a cough producing sputum, and difficulty
breathing, which Dr. Lancaster said was extremely common in anyone who his sick with a cold
or other illness. Id. at 1044, 1047. That indicates petitioner’s autonomic nervous system was
working, not that it was not working. Id. at 1047. Dr. Lancaster said that he did not observe any
actual syncope petitioner was having despite seeing many syncope-like events. Id. at 1052.
        Dr. Lancaster said Dr. Cintron was missing vital information when he diagnosed
petitioner. Id. at 1055. Dr. Cintron was missing the Johns Hopkins Hospital medical records.
Id. In none of Dr. Cintron’s notes did Dr. Lancaster see a good discussion of petitioner’s
seizure-like events in assessing whether they were seizures or non-epileptic seizures. Id. at 1056.
       Dr. Lancaster said that POTS is a clinical syndrome that is very loosely and
problematically defined. Id. at 1089. He has diagnosed several patients with autonomic
disorders but, in general, he does not diagnose people with POTS. Id.

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        On redirect, Dr. Lancaster said that petitioner’s antibodies were never tested for
acetylcholine receptors. Id. at 1099. In his opinion, she does not have autoimmune autonomic
neuropathy or autoimmune autonomic ganglionopathy. Id. Petitioner’s minimal heart murmur is
due to a structural issue and not due to an autonomic disorder. Id. at 1104.
                                    Dr. Whitton’s Testimony
        Respondent’s second expert, Dr. James L. Whitton, testified. Id. at 872. He works at the
Scripps Research Institute in La Jolla, California. This is not the same Scripps as Scripps Health.
Id. Scripps Research Institute is a large nonprofit research institute of independent investigators.
Id. at 872-73. Dr. Whitton has been there 31 years. Id. at 873. Dr. Whitton is in the department
of immunology and microbial science. Id. He has studied vaccines extensively. Id. at 874. He
has also studied the immune response to viral infection. Id. He studies how vaccines impact the
immune system. Id. at 874. Dr. Whitton has a medical degree but is not a licensed medical
doctor and not licensed to practice medicine in the United States. Id. at 875. He also has a Ph.D.
Id. He does not treat patients. Id. at 876. Dr. Whitton’s role in this case is to comment on the
mechanisms Dr. Steinman proposed for the cause of disease. Part of Dr. Whitton’s lab work
focuses on how viruses cause disease, rather than looking at the immune response. Id.
        Recognizing that Dr. Steinman’s opinion evolved over the reports and during the hearing,
Dr. Whitton said that two conditions at issue are rhabdomyolysis and autoimmune dysautonomia.
Id. at 880. There is also the issue of myasthenia gravis. Dr. Whitton describes Dr. Steinman’s
theory as flu vaccine inducing an immune response that cross-reacted with petitioner’s myelin.
Id. Dr. Steinman’s argument is that flu vaccine components attacked the preganglionic fibers of
petitioner’s autonomic nervous system. Id. at 881. Dr. Steinman’s thesis is that destruction of
the myelin on these preganglionic fibers causes autonomic dysfunction. Dr. Whitton was
surprised that one of the autonomic symptoms Dr. Steinman described as being affected included
walking. Id.
         Dr. Whitton described molecular mimicry as an immune reaction of a host protein to a
viral or bacterial protein. Id. at 882. The two proteins have to be sufficiently different to trigger
an immune response, but sufficiently similar so that response, once triggered, can attack the host
protein. Id. at 882-83. An example of molecular mimicry is the use of rabies vaccine causing
neuroparalysis among vaccinees. Id. at 883. The rabies vaccine was prepared in animal brains.
Id. at 884. Roughly 0.5 percent of vaccinees developed encephalitis. Id. at 884-85. Dr. Whitton
said molecular mimicry is not easy to trigger because with rabies vaccine including both animal
brain protein and rabies protein, and with multiple injections, only 0.5 percent of people
developed encephalitis. Id. at 887. He said this vaccine had quite a bit of homology since the
central nervous system proteins of sheep and the central nervous system proteins of humans have
a lot of homology. “Sequence homology” means at the level of individual amino acids. Id.
        Dr. Whitton said Dr. Steinman discussed the sequence FFKN present in myelin basic
protein and compared that to FYKN present in some strains of flu virus. Id. at 888. When one
compares FFKN to FYKN, there is no identity. Id. Dr. Steinman proffered four theories, the
first two based on myelin basic protein. Id. at 891. The first theory could be called the myelin

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basic protein antibody theory. The second theory could be called the myelin basic protein T-cell
theory. Both theories rely on homology or substantial cross-reactivity between a vaccine
sequence that petitioner did not receive because Dr. Steinman picked a subsequent flu vaccine
season flu vaccine. Because of Dr. Steinman’s mistaken analysis of the incorrect flu vaccine, Dr.
Whitton considers those first two theories out of the discussion. The third theory is a sequence in
the Brisbane component of the flu vaccine triggered a cross-reactive response that could attack
one of two different myelin proteins. Id. One is called MOG and the other is called CNPase. Id.
at 891-92. Dr. Whitton did a search of A/Brisbane/10/2007 and discovered it is not an immune
epitope capable of triggering an immune response. Id. at 892. He said no one has ever shown
that the Brisbane H3N2 virus induces a T-cell response. Id.
         Dr. Whitton said that Dr. Steinman was no longer talking about myelin basic protein but
MOG or a component of myelin called myelin oligodendrocyte glycoprotein for which
autoimmune responses to MOG in animal models indicate the autoimmune damage tends to be
more restricted to the central nervous system than to the peripheral nervous system. Id. at 895.
Dr. Steinman’s thesis is that there is a very highly specific attack on either MOG or CNPase in
this subset of peripheral nerve cells on the preganglionic fibers. Id. He uses the Markovic-Plese
article (Ex. 152) as proof of his thesis. Id. at 897-88. The subject that the authors studied had
MS and an acute active flu A virus infection. Id. at 899. The authors took blood from the patient
and made a T-cell clone. Id. The authors then incubated the mixture of T-cells with a specific
peptide that represents a viral epitope. The sequence of the epitope was PKYVKQNT-KLAT.
Id. The authors asked themselves what other peptide sequences might stimulate the T-cell clone.
Id. at 900. Flu A viruses all stimulated the clone. Id. at 901. The authors took four peptides: (1)
the viral peptide; (2) and (3) oligodendrocyte myelin glycoproteins (“MOG”); and (4) CNPase.
Id. at 902. The viral peptide was the positive control. Id. at 902-03. The authors stimulated the
T-cell clone with either no peptide or a lot of peptide. Id. As they increased the peptide dose,
they increased the division of the T-cells. Id. The two MOG peptides stimulated the T-cell
clone a little bit. Id. at 904. The best stimulation came from the CNPase peptide. Id.
        Dr. Whitton said that a researcher doing synthetic peptide stimulation adds billions of
peptides to the well. Id. at 905. That opens the experiment to artifacts. Id. Research with
actual, not synthetic, peptide sequences can be very different. Id. at 906. Going back to the
Markovic-Plese article, Dr. Whitton pointed out that the sequence of the CNPase, which is
LYSLGNGRWN, when compared to the viral sequence, which is UVKNTLKLE, is not very
homologous. Id. at 908. The authors state the same conclusion on page 37 (internally marked
page 7) of their paper: the CNPase-derived peptide had no homology with the native flu HA
epitope. Id.
         Dr. Whitton asked what is the evidence that a T-cell might be pathogenic. Id. at 908. Dr.
Steinman is making many presumptions. Dr. Whitton does not see evidence that the vaccine
induces a T-cell that could cross-react with MOG or CNPase. But if it did, does that mean the T-
cell is pathogenic? Id. Dr. Whitton said a T-cell might not be the cause of an illness but the
result of it. Id. at 909. Dr. Whitton does not think flu vaccine induces pathogenic T-cells that

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attack a very specific place in the peripheral nervous system. Id. at 910. He would call a T-cell
or an antibody autoimmune only if it causes disease. Id. at 911.
         Dr. Whitton described Dr. Steinman’s fourth theory that flu virus triggers the induction in
a vaccinated or infected host of antiganglioside antibodies which then attack gangliosides which
are components of myelin. Tr. at 912. Dr. Whitton notes that antiganglioside antibodies have
been implicated in GBS particularly GBS that Campylobacter jejuni causes. Id. Dr. Steinman
testified that this theory was his most important theory, although it only appeared in Dr.
Steinman’s fifth expert report. Id. at 913. Dr. Whitton turned to the Nachamkin article (Ex. LLL
and Ex. 146). Id. at 914. The article is based on the observation of the increase in number of
GBS cases among swine flu vaccine recipients compared to the number of baseline GBS cases in
people not vaccinated. Id. The authors found that the swine flu vaccine induced antiganglioside
antibodies, but also found that additional flu vaccines not associated with an increased incidence
of GBS also induced anti-ganglioside antibodies, as well as IgM and IgG antibodies in mice. Id.
at 916.
        Dr. Whitton turned his attention to the Lei article (Ex. OOO). Id. at 918. The study’s
aim was to find out if the 2009 H1N1 vaccine induced antiganglioside antibodies in humans and
mice. Eight patients had post-vaccination GBS after receiving this vaccine. Id. The authors did
not detect antibodies against ganglioside in any of these people or in vaccinated mice. Id. at 918-
19. The authors conclude their study results do not support the proposition that flu viruses or flu
vaccines induce antiganglioside antibodies. Id. at 919.
        Dr. Whitton explained that flu viruses have a receptor called hemagglutinin which binds
to the cell the flu virus wants to infect, and the molecule called sialic acid facilitates cell entry.
Once the virus gets into the cell, it replicates. The virus then exits the cell to infect other cells.
Id. Neuraminidase is an enzyme in the virus that cleans the sialic acid, releasing the virus from
the infected cell. Id. at 919-20. But the virus trails little pieces of the host cell as it escapes from
the cell. Id. at 920. The human or mouse forms antibodies to the little pieces of the host cell.
That the virus is grown in eggs means that the pattern of glycosylation, i.e., the types of sugars
(the sialic acids) might slightly differ from mammalian cells, which increases the chance of
inducing antiganglioside antibodies in a human. Dr. Whitton notes that the authors of this study
specifically attempted to confirm the Nachamkin article results and could not confirm them. Id.
        Because of the Nachamkin and Lei articles, Dr. Whitton does not believe petitioner’s flu
vaccination induced antiganglioside antibodies. Id. at 930. These two articles do not support Dr.
Steinman’s thesis that flu vaccine induced in petitioner an antiganglioside antibody response. Id.
at 931. He also does not believe that the flu vaccine petitioner received induced a T-cell
response to MOG or CNPase. Id. Dr. Whitton said that antibodies are not associated with
rhabdomyolysis. Id. at 932. He thinks the cause of petitioner’s rhabdomyolysis is much more
likely to be either petitioner’s concurrent viral infection or exercise or both. Id. at 932-33. He
does not think that flu vaccine caused petitioner’s rhabdomyolysis. Id. at 933.
        As for autoimmune autonomic neuropathy, Dr. Whitton testified there is no evidence that
flu vaccine can cause an antibody response against the acetylcholine receptor. Id. Dr. Whitton

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recalled that once Dr. Steinman learned at the hearing that he had analyzed the wrong flu vaccine
(2010-2011 instead of 2009-2010), Dr. Steinman said he could not link through homology flu
vaccine with acetylcholine receptor because there is no known homology. Id. at 934. Dr.
Whitton said he disagrees with the theory that flu vaccine induces an immune response against
the myelin in the preganglionic fibers of the autonomic nervous system to cause autoimmune
autonomic neuropathy. Id. at 235. Dr. Whitton does not accept Dr. Steinman’s theory that flu
vaccine caused an anti-myelin response in the peripheral nerves which innervate muscles and
caused myasthenia gravis. Id.
        Dr. Whitton said it is very common to have autoreactive antibodies that do not cause
disease in healthy people. Id. at 936-37. Even if someone has antiganglioside antibodies, one
cannot conclude that induces pathogenic disease. Id. at 937. Dr. Whitton’s opinion is that
petitioner’s flu vaccination did not cause any of her alleged injuries. Id.
        On cross-examination, Dr. Whitton explained that to cause disease, a scientist does not
want total homology but something close to it. Id. at 947. He accepts that molecular mimicry is
mainstream science. Id. at 961. The Markovic-Plese article states the protein sequence is not
homologous at the amino acid level. Id. The CNPase-derived peptide had no homology with the
native flu HA epitope. Id. at 962. Markovic-Plese does not show a reaction to vaccine. Id. at
971. It shows a reaction to a peptide taken from a vaccine. Id.
        On redirect, Dr. Whitton said that muscle cells are not myelinated. Id. at 988. Muscle
cells are innervated by myelinated nerves. Id. GBS can cause rhabdomyolysis and neurogenic
problems with muscles, inducing creatine kinase. Id. at 989. “Innervated” means they have a
nerve cell connection. The electricity changes into chemistry at the synapse and the electricity is
restored at the level of the myocyte (the muscle cell). Id. In other words, “innervation” means
stimulus. Id.
                                          DISCUSSION
        To prevail under the Vaccine Act, petitioner must prove by preponderant evidence that a
vaccination caused her injury. 42 U.S.C. §§ 300aa-11(c)(1), -13(a)(1)(A). If petitioner’s alleged
injury satisfies the criteria of being a Table injury, the Act presumes causation. 42 U.S.C. §
300aa-11(c)(1)(C)(i); Broekelschen v. Sec’y of HHS, 618 F.3d 1339, 1341-42 (Fed. Cir. 2010);
Andreu v. Sec’y of HHS, 569 F.3d 1367, 1374 (Fed. Cir. 2009). Where, as in the instant action,
petitioner’s alleged injuries are not Table injuries, she must prove causation in fact.
Broekelschen, 618 F.3d at 1342 (citing Moberly ex rel. Moberly v. Sec’y of HHS, 592 F.3d
1315, 1321 (Fed. Cir. 2010)). To prevail in a causation-in-fact case, “petitioner must show that
the vaccine was ‘not only a but-for cause of the injury but also a substantial factor in bringing
about the injury.’” Stone v. Sec’y of HHS, 676 F.3d 1373, 1379 (Fed. Cir. 2012) (quoting
Shyface v. Sec’y of HHS, 165 F.3d 1344, 1352-53 (Fed. Cir. 1999)). “Once petitioner has
demonstrated causation, she is entitled to compensation unless the government can show by a
preponderance of the evidence that the injury is due to factors unrelated to the vaccine.”
Broekelschen, 618 F.3d at 1342 (citing Doe v. Sec’y of HHS, 601 F.3d 1349, 1351 (Fed. Cir.
2010); 42 U.S.C. § 300aa-13(a)(1)(B)).

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       To satisfy her burden of proving causation in fact, petitioner must prove by preponderant
evidence: “(1) a medical theory causally connecting the vaccination and the injury; (2) a logical
sequence of cause and effect showing that the vaccination was the reason for the injury; and (3) a
showing of a proximate temporal relationship between vaccination and injury.” Althen v. Sec’y
of HHS, 418 F.3d 1274, 1278 (Fed. Cir. 2005). In Althen, the Federal Circuit quoted its opinion
in Grant v. Secretary of Health and Human Services, 956 F.2d 1144, 1148 (Fed. Cir. 1992):
                 A persuasive medical theory is demonstrated by “proof of a logical
                 sequence of cause and effect showing that the vaccination was the
                 reason for the injury [,]” the logical sequence being supported by a
                 “reputable medical or scientific explanation[,]” i.e., “evidence in
                 the form of scientific studies or expert medical testimony[.]”
418 F.3d at 1278.
       Without more, “evidence showing an absence of other causes does not meet petitioner’s
affirmative duty to show actual or legal causation.” Grant, 956 F.2d at 1149. Mere temporal
association is not sufficient to prove causation in fact. Id. at 1148.
       The Federal Circuit has held that petitioner must present more than a possible causal link
between vaccination and injury; moreover, the causal link must be based upon persuasive and
reputable evidence. Paterek v. Sec’y of HHS, 527 F. App’x 875, 879 (Fed. Cir. 2013).
        The Federal Circuit in Capizzano v. Secretary of Health and Human Services, 440 F.3d
1317, 1326 (Fed. Cir. 2006), emphasized that special masters are to evaluate seriously the
opinions of petitioner’s treating doctors since “treating physicians are likely to be in the best
position to determine whether a logical sequence of cause and effect show[s] that the vaccination
was the reason for the injury.” See also Broekelschen, 618 F.3d at, 1347; Andreu v. Sec’y of
HHS, 569 F.3d 1367,1375 (Fed. Cir. 2009). Dr. Steinman calls petitioner’s treating doctors
“boots on the ground.” Petitioner has seen and/or had tests interpreted by 56 doctors163 and two
psychologists,164 and has visited 11 medical institutions.165 The undersigned has evaluated

163
    Dr. Zachary Malachias, Dr. Brian A. Hazen, Dr. Pranav Vermani, Dr. Sarbjot S. Dulai, Dr. Ho-Song Lee, Dr.
Jeffrey S. Luy, Dr. Michael Rodriguez, Dr. Sarfraz A. Choudhary, Dr. Scott Weir, Dr. Mohammed A. Mannan, Dr.
Elise Berman, Dr. Jonathan Bresner, Dr. Paul M. Dellemonache, Dr. Garry Ho, Dr. Julius C. Pham, Dr. Anjail
Sharrief, Dr. Victor C. Urrutia, Dr. Christopher C. Oakley, Dr. Ruben Cintron, Dr. Rashid Buttar, Dr. Randolph R.
Stephenson, Dr. Mark P. Tanenbaum, Dr. Nick Cossa, Dr. David Kruse, Dr. Pradeep Nayak, Dr. Arun Kumar, Dr.
Walter Atiga, Dr. Stuart A. Fruman, Dr. Farhad Zangeneh, Dr. Neil Q. Tran, Dr. Frisca Yan-Go, Dr. Kevin
Ghassemi, Dr. Sheri Hart, Dr. Robert A. Wohlman, Dr. Daniel V. Wilkinson, Jr., Dr. Blair Grubb, Dr. Kelly E.
Williams, Dr. Alan D. Waxman, Dr. Elmer Y. Chang, Dr. Mariko L. Ishimori, Dr. Patrick J. Olek, Dr. Swaraj Bose,
Dr. Sam Kipper, Dr. Daniel J. Wallace, Dr. Joey R. Gee, Dr. Jackson W. Penry, Dr. Raj Patel, Dr. Loan T. Nguyen,
Dr. Jagmeet S. Mundi, Dr. Geoffrey L. Sheean, Dr. Craig A. Salcido, Dr. Robert Y. Goldberg, Dr. Oscar H. Otanez,
Dr. Eric A. Glasser, and Dr. Brian Barry.
164
    Dr. Christine Cosgrove and Dr. Sidney Binks.
165
    Inova Loudon Hospital (twice), Fairfax Hospital, Johns Hopkins Hospital, Reston Hospital, Inova Fair Oaks
Hospital, Swedish Medical Center, Toledo Medical Center, Cedars-Sinai Medical Center, Mission Hospital, Mayo
Clinic (petitioner did not file any records from the Mayo Clinic but mentioned to Dr. Yan-Go that she had been
there), and MedStar Georgetown Hospital.

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seriously all the opinions of these 58 doctors and 11 medical institutions in forming an opinion
about this case.
        Other than there being no dispute that petitioner had rhabdomyolysis in early September
2009, the opinions of these treating physicians fall within three categories: (1) petitioner has
conversion disorder and there is nothing physically wrong with her; (2) petitioner has
dysautonomia; or (3) petitioner has dysautonomia and conversion disorder. Doctors have also
diagnosed petitioner with numerous other medical maladies: gastroparesis, stiff person
syndrome, myasthenia gravis, POTS, autoimmune autonomic neuropathy, autoimmune
encephalopathy, unspecified GAD65 disorder, and cerebellar ataxia. No doctor has diagnosed
petitioner with GBS or optic neuritis although petitioner has given a history to doctors that she
had both. Those doctors who had access to petitioner’s previous medical records note in their
own medical records that she did not have GBS and that her eyes are normal.
       Where there is a discrepancy between what petitioner tells her later doctors compared to
what the earlier doctors wrote in their medical records, the undersigned believes the earlier
medical records when the later doctors base their diagnoses on what petitioner tells them rather
than on the earlier medical records. Where there is a discrepancy between what petitioner
declared in her filed court statements or testified about in the hearing and the contemporaneous
medical records, the undersigned finds more credible the contemporaneous medical records.
Well-established case law holds that information in contemporary medical records is more
believable than that produced years later at trial. United States v. United States Gypsum Co.,
333 U.S. 364, 396 (1948); Burns v. Sec’y of HHS, 3 F.3d 415 (Fed. Cir. 1993); Ware v. Sec’y of
HHS, 28 Fed. Cl. 716, 719 (1993); Estate of Arrowood v. Sec’y of HHS, 28 Fed. Cl. 453 (1993);
Murphy v. Sec’y of HHS, 23 Cl. Ct. 726, 733 (1991), aff'd, 968 F.2d 1226 (Fed. Cir.), cert.
denied sub nom. Murphy v. Sullivan, 113 S. Ct. 263 (1992); Montgomery Coca-Cola Bottling
Co. v. United States, 615 F.2d 1318, 1328 (1980). Contemporaneous medical records are
considered trustworthy because they contain information necessary to make diagnoses and
determine appropriate treatment:
               Medical records, in general, warrant consideration as trustworthy
               evidence. The records contain information supplied to or by health
               professionals to facilitate diagnosis and treatment of medical
               conditions. With proper treatment hanging in the balance,
               accuracy has an extra premium. These records are also generally
               contemporaneous to the medical events.
Cucuras v. Sec’y of HHS, 993 F.2d 1525, 1528 (Fed. Cir. 1993).
                                      Conversion Disorder
        The medical records and/or Dr. Steinman’s 10 reports name 21 illnesses or conditions
that petitioner has or might have, not all of which she alleges flu vaccine caused: (1) viral
infection; (2) rhabdomyolysis; (3) seizures; (4) GBS; (5) dystonia; (6) dysautonomia; (7)
autonomic autoimmune neuropathy/autonomic immune ganglionopathy; (8) POTS; (9)
neurocardiogenic syncope; (10) vagal nerve damage (11) gastroparesis; (12) myasthenia gravis;
(13) stiff person syndrome; (14) optic neuritis; (15) Raynaud’s of the brain; (16) cerebral brain
flow problems; (17) systemic lupus erythematosus; (18) mercury poisoning; (19) GAD

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antibodies-associated syndrome, (20) intestinal pseudo-obstruction; and (21) conversion
disorder.
        The undersigned starts this discussion with the last condition, conversion disorder. This
is respondent’s defense of a known factor unrelated to vaccination, 42 U.S.C. § 300aa-13(a)(1).
Respondent does not have the burden of proving a known factor unrelated to flu vaccine is the
cause in fact of petitioner’s symptoms unless petitioner makes a prima facie case that flu vaccine
caused at least one of her 20 illnesses and conditions. Respondent also defends that petitioner
has failed to make a prima facie case that she has any physical illness other than her transient
rhabdomyolysis.
        The Federal Circuit held in Broekelschen that determining “causation turns on which
injury [petitioner] suffered.” 618 F.3d at 1346. The issue in that case was whether flu vaccine
caused Dr. Broekelschen transverse myelitis or anterior spinal artery syndrome. Id. at 1342. Dr.
Steinman, petitioner’s expert in the instant action, was also Dr. Broekelschen’s expert. The
special master found respondent’s neurologic expert more credible than Dr. Steinman, thus
dismissing the case. Dr. Broekelschen appealed on the basis that the special master first had to
determine if petitioner made a prima facie case of causation in fact and, only then, decide if
respondent’s known factor unrelated (anterior spinal artery syndrome) was the cause in fact of
petitioner’s condition. The Federal Circuit disagreed, stating “nearly all the evidence on
causation was dependent on the diagnosis of Dr. Broekelschen’s injury.” Id. at 1346.
        The way the instant action has developed is remarkable in that the experts, counsel, and
the undersigned have had the unique privilege of seeing contemporaneous videos of petitioner
within one month of her flu vaccination when she was on national television broadcasts and
visiting Dr. Buttar’s clinic in North Carolina. Thus, the experts did not have to rely solely on the
contemporaneous medical records to evaluate whether petitioner had a physical illness and, if she
did, what was the identity of that illness. Petitioner also had her own website in which she spoke
directly to her audience. Interestingly, Dr. Steinman in his testimony said he was more
impressed meeting petitioner in person (right before the hearing) than in reading PDFs of her
medical records or watching videos on, as he put it, a little screen. His downplaying the
importance of those videos is in stark contrast with respondent’s expert Dr. Lancaster who called
the videos central to the case. The undersigned finds Dr. Lancaster more persuasive about the
importance of the videos than Dr. Steinman.
        The undersigned relies more on Dr. Lancaster’s opinion concerning whether petitioner
manifested dystonia, dysautonomia, or autoimmune autonomic neuropathy/autoimmune
autonomic ganglionopathy when she was violently flailing her arms and bopping her head up and
down while trying to walk a precipitously narrow line forward, but having no problem running
forward or walking backward or sideways. The undersigned analyzes the two striking details of
these videos, i.e., supposed seizures and purported dystonia affecting petitioner’s ability to walk
forward and whether these are symptomatic of conversion disorder.
                                             Seizures
        The parties might wonder why the undersigned is discussing seizures when, for the first
time in this case, petitioner recanted at the hearing that she ever had seizures, using the excuse
that she is not a doctor and just assumed the violent bopping of her head up and down was
seizures. The reason is the analysis of the videos is central to evaluating the credibility of Dr.

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Steinman as an expert in this case. Dr. Lancaster in his first expert report (Ex. H) went
painstakingly through each video and described what each video out of 14 hours of videos
showed petitioner doing and what his professional opinion of it was. He wrote and testified that
petitioner was manifesting psychogenic seizures, in other words, fake seizures. When, a year
later, Dr. Steinman wrote his report (Ex. 141) after seeing some of the same videos, his only
comment about petitioner’s violent bopping of her head was he would need a concomitant EEG
and preferably a video EEG in order to comment. Yet, the medical records show that petitioner
always had normal EEGs, even when Ms. Preston falsely diagnosed petitioner with an abnormal
qEEG. Dr. Cintron, one of petitioner’s neurologists who is not only board certified in neurology
but also in neuromuscular EMG, reanalyzed the qEEG and then did his own EEG, showing
petitioner had a normal EEG.
        Dr. Steinman at the hearing was still waffling about whether petitioner had seizures, but
he clearly did not pursue the point in his testimony, which when respondent’s counsel Ms.
Walters whittled it down to its essence was that he believed flu vaccine caused petitioner
autoimmune autonomic neuropathy and vagus nerve injury. Seizures are a central nervous
system problem and petitioner never had a central nervous system problem. Dr. Steinman agreed
that the SPECT scan that purportedly showed cerebral blood flow problems was inaccurate,
agreeing with Dr. Lancaster. Moreover, all of petitioner’s brain MRIs were normal as were her
EEGs. The PET scan of her brain after the falsely positive SPECT scan was also normal.
       The undersigned finds that petitioner never had seizures.
                                          Astasia-Abasia
        The second notable phenomenon of these videos is crucial to understanding whether
petitioner had a physical illness or conversion disorder, i.e., astasia-abasia. Dr. Lancaster wrote
in Ex. H and testified that petitioner’s narrow, jerky, twisting walk forward with her arms flailing
is astasia-abasia, a typical symptom of conversion disorder. He noted that it is actually difficult
to walk like that, and, thus, only someone in good physical condition, as petitioner was, can
manage it without falling down.
       Dr. Lancaster is not alone in noting that petitioner displayed astasia-abasia. Dr. Victor C.
Urrutia, a neurologist, noted petitioner had astasia-abasia (med. recs. Ex. 55, at 85). Dr.
Randolph R. Stevenson, a neurologist, noted petitioner had astasia-abasia (med. recs. Ex. 22, at
37).
        Dr. Steinman likes to use the phrase “boots on the ground” in describing in his expert
reports and testimony how important treating doctors’ opinions are in forming his own opinion.
Yet, not only does Dr. Steinman not consider Dr. Urrutia’s and Dr. Stephenson’s diagnoses that
petitioner had astasia-abasia and, thus, conversion disorder, but also Dr. Steinman never
commented once in Ex. 141 or in his testimony about the contemporaneous videos showing
petitioner had astasia-abasia and not dystonia. Instead, Dr. Steinman testified that it was only
when he saw the videos that he thought petitioner had dystonia. Tr. at 492-93. He reasoned that
petitioner could not have known that if she walked backward, she would not have the flailing and
jerky walk she had walking forward. Id. at 493. But Dr. Lancaster testified that petitioner stated
in the videos that she read on the Internet about dystonia and learned that some dystonia patients
could run and not walk. Then she went and experimented and, each time, walking backward

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worked, which Dr. Lancaster attributed to the power of suggestion coming from the information
on the Internet. Id. at 633.
        Dr. Lancaster cogently explained that petitioner’s manifestations of various symptoms
involving numerous anatomic sites is exactly the behavior the Hallett article on psychogenic
movement disorders describes (Ex. ZZ). As petitioner’s treating neurologist Dr. Stephenson
depicted in his notes of December 2009, petitioner’s movements had variability (manifesting
different planes of direction), suggestibility, distractibility, and instant appearance and
disappearance at multiple loci. Med. recs. Ex. 22, at 36-37.
        What Dr. Steinman could not explain medically was why Dr. Buttar’s treatment of
petitioner with IVs of saline and/or glucose in water would not only cure her POTS, but also her
inability to walk and speak appropriately. Dr. Steinman attributed that “cure” to the placebo
effect. But he adamantly continued to believe that petitioner’s alleged dystonia was real. The
undersigned finds Dr. Lancaster’s opinion that petitioner had astasia-abasia, i.e., conversion
disorder, more persuasive than Dr. Steinman’s opinion that petitioner had dystonia. Dr.
Lancaster said he has had 50-100 patients seeing him for a neurological diagnosis who, in fact,
manifested conversion disorder. Dr. Steinman never testified that he has the experience of
patients who seek his neurologic help but in fact had conversion disorder. Dr. Lancaster, through
his greater experience of conversion disorder, is the more credible expert on this diagnosis than
Dr. Steinman.
         In addition, although Dr. Steinman emphasizes the importance of “boots on the ground”
for those doctors having opinions favorable to petitioner’s allegations, he ignores the fact that
most of these doctors did not see the videos that Dr. Lancaster, Dr. Steinman, and the
undersigned saw. Petitioner asserts that Dr. Gee saw the videos, and she asserted that he thought
they bore out that she had dystonia. But when the undersigned ordered petitioner to obtain and
file a statement from Dr. Gee about his opinion, according to petitioner’s attorney in a status
report, Dr. Gee never gave her a statement. Moreover, when petitioner was transported by EMTs
to Medstar Georgetown Hospital on the second day of the hearing, staying there for a few days,
Dr. Gee phoned Dr. Barry and told him petitioner had a “non-organic dystonia to a flu shot.”
Med. recs. Ex. 179, at 6. Dr. Steinman seems to have ignored Dr. Gee, an important set of boots
on the ground, who is currently acting as petitioner’s treating neurologist and recognizes that
there is not an organic dystonic reaction to a flu vaccination and transmits that information to
another treating neurologist, Dr. Barry, who wrote it in the Georgetown Hospital records.
Petitioner’s reputation at Georgetown Hospital must have been extensive for the dietician Kelsie
N. Hitesman to put in her own notes “psychogenic stridor.” Med. recs. Ex. 183, at 90.
        Dr. Steinman’s reliance on boots on the ground is misplaced when the doctors upon
whose opinion he relies (including Dr. Sheean) were never privileged to watch the videos of
petitioner in October 2009. Moreover, the doctors who examined petitioner even without the
assistance of videos expressed numerous concerns over whether her symptoms were organic:
       1. Inova Fairfax Hospital ED on September 27, 2009, just one month after vaccination,
          had the first treaters to diagnose petitioner with conversion disorder. Dr. Jonathan
          Bresner, a neurologist, noted petitioner’s “movements are extremely peculiar and not
          easily described from a neurological standpoint. It is also odd that the patient’s
          symptoms resolved for a long enough period each morning for her to apply makeup
          but then return so forcefully that she is unable to speak or move her limbs in any sort
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     of coordinated motion. The patient is able to walk despite her inability to control her
     limbs.” Her neurological examination was otherwise normal and she had no signs or
     symptoms of GBS. A psychogenic etiology remained a consideration and she might
     benefit from psychological counseling or a psychiatric evaluation. Med. recs. Ex. 44,
     at 31-32.
2.   Dr. Mohammamed Mannan wrote on September 29, 2009 that petitioner’s condition
     had a possible psychogenic etiology. Petitioner had very odd neurological symptoms.
     Med. recs. Ex. 44, at 13. Dr. Mannan noted the discrepancy of petitioner putting on
     makeup including eyeliner in the hospital, but unable to hold a cup of water in her
     hand. When the nurses confronted her, she stopped putting on makeup. Petitioner’s
     PCP Dr. Rodriguez contacted Dr. Mannan and said he did not see any organic
     etiology either, he was concerned about a psychogenic etiology, and he agreed that
     petitioner should have a psychiatric evaluation. Id. at 14.
3.   Dr. Anjail Sharrief at Johns Hopkins Hospital on October 3, 2009 wrote petitioner’s
     neurological examination had many components that were not physiologic, and likely
     had a psychological overlay. Med. recs. Ex. 2, at 14.
4.   Dr. Victor C. Urrutia, a neurologist, on October 3, 2009 wrote petitioner had a strong
     psychogenic component to her symptoms and she did not have GBS. Med. recs. Ex.
     55, at 12. A neurologic progress note identified petitioner’s gait as astasia-abasia. Id.
     at 85. Dr. Urrutia also wrote that petitioner’s symptoms “do not fit a physiologic
     paradigm” and could be due to anxiety. Id. at 15. Dr. Urrutia suggested petitioner
     see a therapist and noted she felt better after taking Ativan. Id.
5.   Dr. Christopher Oakley on October 4, 2009 wrote petitioner was having a stress
     reaction and anxiety. He recommended she see a therapist or a psychiatrist. Med.
     recs. Ex. 55, at 6.
6.   Dr. Garry Ho wrote on October 6, 2009 that if petitioner did not have anything further
     on work up, he would strongly consider she had a conversion disorder, delusional
     disorder, or other psychogenic etiology. Med. recs. Ex. 22, at 14. He also notes that
     petitioner said she was perfectly normal for 10 hours when she took her then-
     husband’s valium. Id. at 12.
7.   Dr. Randolph R. Stephenson, a neurologist, wrote on December 7, 2009 that
     petitioner had astasia-abasia when he saw her gait on physical examination. Med.
     recs. Ex. 22, at 37. He noted she had a very clear functional component to her
     physical examination and no neurological findings that would suggest any particular
     organic disease. Id.
8.   Dr. Reuben Cintron, a neurologist, wrote on January 19, 2010 that petitioner had
     “some bizarre aspects to her disease.” Med. recs. Ex. 1, at 9. He also noted on March
     16, 2010 that petitioner’s symptoms were still bizarre and there was no objective
     evidence of where the problems were coming from. Id. at 7. He added on February
     3, 2011, “In summary her medical and neurological situation has been at best
     confusing and very difficult to intellectually define.” Med. recs. Ex. 16, at 1. He
     stated petitioner was exercising “almost to a pathological amount.” Id.
9.   Dr. Frisca Yan-Go, a neurologist specializing in autonomic neuropathy, wrote on
     August 15, 2010 that petitioner had a functional overlay and conversion reaction.
     Med. recs. Ex. 18, at 1.

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       10. Dr. Daniel Wilkinson, a cardiologist, wrote on February 2, 2011 that petitioner had
           multiple “very unusual symptoms.” Med. recs. Ex. 12, at 1.
       11. Dr. Patrick Lyden, a neurologist, wrote on January 10, 2012, that petitioner had a
           “very complicated case” and an “unsuspected psychiatric diagnosis.” Med. recs. Ex.
           54, at 10. He added on January 13, 2012 that petitioner “embellished symptoms” and
           needed a good psychological evaluation. Id. at 12.
       12. Dr. Michael Olek, an osteopath, wrote on February 29, 2012, “At this time, it is
           difficult to have a unifying diagnosis.” Med. recs. Ex. 61, at 4.
       13. Dr. Joey Gee, an osteopath functioning as petitioner’s neurologist, wrote her
           underlying diagnosis was an “enigma.” Med. recs. Ex. 115, at 5. Dr. Gee noted on
           July 18, 2012 that petitioner’s neurologic tests were unremarkable. Id. at 10.
       14. Dr. Brian Barry, a neurologist, wrote on June 15, 2016 that petitioner had “effort
           dependence” on physical examination at Medstar Georgetown University Hospital.
           Med. recs. Ex. 179, at 5. On that same date, Dr. Gee telephoned Dr. Barry and told
           Dr. Barry that petitioner had a “non-organic dystonia attributed to a flu shot.” Id. at
           6.
        The negative opinions of the above 14 doctors about the medical legitimacy of
petitioner’s complaints were from her physical examinations, yet Dr. Steinman ignores their
concerns even though their boots were on the ground at the time petitioner claimed the illness
that Dr. Steinman now interprets as dystonia.
        Dr. Steinman also ignores petitioner’s misinforming doctors by giving them a history that
she had GBS when her doctors on more than one occasion in two separate hospitals examined
her specifically looking for GBS and concluded that since she had normal reflexes, a normal
protein count in her CSF, and no paralysis, she did not have GBS. When doctors heard from her
that she had GBS, they were more likely to ascribe her history of having autonomic nervous
system symptoms to the well-established component of a reaction to flu vaccine. On the witness
stand, Dr. Steinman agreed that autoimmune autonomic neuropathy and GBS are at either end of
the spectrum of inflammatory neuropathy and did not press his written view that autoimmune
autonomic neuropathy was a variant of GBS. Moreover, he finally admitted in his testimony that
GBS was out of the case.
        Dr. Steinman also ignores petitioner’s misinforming doctors by giving them a history that
she had optic neuritis when Dr. Swaraj Bose, a neuro-ophthalmologist with stellar credentials,
examined her and found nothing wrong with her eyes. Petitioner’s website (for which the
undersigned would give the URL but the undersigned redacted this case to petitioner’s initials at
petitioner’s request) shows her using a straight edge of a paper in order to read a computer
screen, as if she had something wrong with her eyes. Having vision problems is one sign of
myasthenia gravis which Dr. Sheean diagnosed petitioner as having. Dr. Sheean is the doctor
upon whom Dr. Steinman relies in opining that petitioner has myasthenia gravis, even though it
is not Dr. Steinman’s “favorite” diagnosis. He said he was not personally wild about that
diagnosis and myasthenia gravis was not a cornerstone of his opinion.
        Finally, Dr. Steinman diagnosed petitioner with only autoimmune autonomic neuropathy
and vagus nerve injury. Petitioner’s misinforming doctors about her history did not persuade
him even a little that petitioner has conversion disorder. When pressed at the hearing whether
petitioner could have both conversion disorder and physical illness, he mused that one day we

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may find an organic reason for psychogenic behavior. He said a person could have an illness
that was so upsetting that it led to abnormal behavior. Yet, he had just testified Dr. Buttar’s use
of repeated IVs on petitioner worked not only for her POTS by hydrating her, but also improved
her alleged inability to walk forward and speak normally because they had the placebo effect.
He recognized IVs cannot improve someone’s ability to walk forward and speak normally
because blood volume is not pertinent to those activities.
        The impression the undersigned received from Dr. Steinman’s testimony as well as from
his expert reports is he is uncomfortable staying with one position and flits back and forth from
opinion to opinion to assist petitioner in prevailing, even if he does not eventually believe what
he wrote or said. Dr. Steinman is the essence of a team player, in other words, an advocate. Dr.
Steinman’s testimony is inconsistent with his own opinions on the stand as well as his opinions
in his expert reports, inconsistencies that do not engender credibility.
        Dr. Steinman on the witness stand finally rethought and narrowed down what his opinion
was: petitioner had autoimmune autonomic neuropathy and vagus nerve damage that her August
23, 2009 flu vaccination caused. As Dr. Lancaster critically notes, the events depicted in the
videos and the initial physical examinations of petitioner occurred within the first couple of
months after petitioner’s August 23, 2009 flu vaccination. If petitioner later had other illnesses,
such as POTS, gastroparesis, and/or myasthenia gravis, petitioner has not alleged that flu vaccine
caused these diseases months if not years later. The first few months after the flu vaccination,
from August 23 to October 23, 2009, make or break petitioner’s chance of prevailing in this case,
a point Dr. Lancaster made.
        Dr. Steinman tried repeatedly in his 10 reports to create a grand picture: flu vaccine
caused her rhabdomyolysis, GBS, and myasthenia gravis, whose onsets occurred at the same
time (20 days post-vaccination). Then, he moved on to dystonia and to dysautonomia. Then he
progressed to autoimmune autonomic neuropathy/autoimmune autonomic ganglionopathy. He
was still hanging on to his “inference” of GBS. Further down the road, he added gastroparesis
and POTS. Finally, he decided she had anti-GAD antibody syndrome which was undetected
earlier because no one tested petitioner’s GAD antibodies in 2009. Respondent through experts
and hardworking counsel hammered away at the grand picture until only autoimmune autonomic
neuropathy and vagus nerve damage were left.
        After petitioner slumped to the ground growling during Dr. Steinman’s testimony on the
second day of the hearing, the undersigned asked Dr. Steinman to attend to her until the EMTs
arrived. When the EMTs removed petitioner from the hearing room to the ambulance, Dr.
Steinman returned to the witness stand and all his usual conviviality went out of him. He looked
disturbed and disheartened. He kept repeating the same statement in response to the
undersigned’s question--that petitioner was moving air, i.e., breathing, and she was not cyanotic.
Respondent’s counsel Ms. Walters sensed Dr. Steinman’s disquietude as well and asked on
cross-examination whether he actually believed petitioner had myasthenia gravis to which he
responded in the affirmative. But Ms. Walters whittled Dr. Steinman down to what he really
believed and he said the illnesses she has due to the vaccine were autoimmune autonomic
neuropathy and vagus nerve damage. He did not mention myasthenia gravis.
        His disinclination for that diagnosis surfaced again in the unusual caveat in the Amended
Petition that petitioner filed after the hearing that myasthenia gravis was not Dr. Steinman’s
“favorite” diagnosis but he relied on Dr. Sheean to support it (and petitioner was still alleging flu
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vaccine caused it). Yet, Dr. Steinman testified that he did not believe petitioner has Lambert-
Eaton Syndrome, another one of Dr. Sheean’s diagnoses. Clearly, the fact that Dr. Sheean
diagnoses an illness is not determinative of Dr. Steinman’s agreement with Dr. Sheean. But
petitioner did not allege flu vaccine caused Lambert-Eaton syndrome and thus Dr. Steinman did
not need to comment on it. The firefly appearance and disappearance of myasthenia gravis as a
diagnosis Dr. Steinman accepted reduced his credibility.
        Dr. Steinman asked in one of his expert reports what else could have triggered
petitioner’s various conditions if not the flu vaccine (ignoring the presence of a viral infection
because he claims no one knows the identity of the virus and therefore it does not count as a
cause). The Federal Circuit in Grant states petitioner’s burden is to prove vaccine causation with
affirmative evidence. 956 F.2d at 1149. Saying since there is no other cause, it has to be the
vaccine is not affirmative proof.
        Dr. Lancaster explains the reason for petitioner’s conversion disorder is a subconscious
manifestation of stress. A number of petitioner’s treating doctors attribute her symptoms to
stress or anxiety (Dr. Urrutia, Dr. Oakley) and prescribed benzodiazepines to alleviate her stress
or anxiety. They also recommended she get psychological or psychiatric help (Dr. Bresner, Dr.
Rodriguez, Dr. Urrutia, Dr. Oakley, Dr. Lyden).
        Conversion disorder gives the person who manifests it attention as well as relief from
anxiety. See supra, n.27. Dorland’s lists the reasons for conversion disorder as: (1) exacerbation
of symptoms at times of psychological stress, (2) relief from tension or inner conflicts (primary
gains) provided by the symptoms, or (3) secondary gains (support, attention, avoidance of
unpleasant responsibilities) provided by the symptoms.
                          Video Evidence in Support of Conversion Disorder
        During one of petitioner’s many conversations with Dr. Buttar that video captured, in
one,166 dated October 21, 2009, she and Dr. Buttar exclaim that divine intervention brought them
together and that her gut was right: mercury was the cause of her condition. She tells Dr. Buttar
he is her hero. Dr. Buttar tells her she is his hero. Dr. Buttar says thank God for the flu shot so
we could learn all this. He says they were opening the pathways that day. He says petitioner
needed an IV167 in case her illness comes back. Petitioner says she is “so waiting for Blue Cross
Blue Shield’s rejection letter” of her claim for reimbursement. Dr. Buttar says petitioner needs
oxygen. She says she needs deep brain stimulation and that she has pure dystonia. Dr. Buttar
says this is going to be big, and health care in general is going to change. Petitioner says her
insomnia is gone. She says she can feel stuff moving back up into her head. She states mercury
went back into her head and paralyzed her tongue, neck, and face, giving her cold spots. Dr.
Buttar says this proves she does not have a psychogenic component to her condition. Petitioner
says it will be hard to make a movie out of her life and wonders who would play her in the movie
and portray the physiologic facts. Dr. Buttar says she is having petit mal seizures and acute
spasms. He says there is probably enough evidence of that without her having an EEG.

166
    This dialogue starts at minute 7:18 on Ex. 58, Video #409_0514_07. This is part of a terabyte of videos that
petitioner filed as Exhibit 58 on a hard drive on May 9, 2012.
167
    Dr. Buttar is not recommending IVIG, but a standard IV. Ex. 58, Video #409_0299_01, at minutes 4:50–5:48, in
a phone conversation Stan Kurtz (onscreen) has with Dr. Buttar (offscreen), Dr. Buttar endorses IV fluids but not
IVIG which he thought would be detrimental to petitioner and could hurt her.

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         In another video,168 dated October 20, 2009, petitioner walks forward without problem to
her then-husband in Dr. Buttar’s clinic waiting room, puts her arms around her then-husband,
tells him she feels good and that she can walk backward, forward, and sideways, exclaims this is
great, and kisses her then-husband. She tells Stan Kurtz’s wife Michelle on a cellphone that
“they fixed her.” She says she can walk and talk. She says it is huge. She says she will show
Michelle all her new tricks. She states, “It went away so fast too.” She says it was the same
burning sensations she had in the MRI at Johns Hopkins because MRIs drew metals to the back
of her brain. She says she knew it had to be metal because nothing else could pull the mercury
down. Petitioner talks about being free again and expresses sympathy for poor autistic kids. She
says she does not know how they deal with it, presumably autism. She says Johns Hopkins
diagnosed her with dystonia and they cannot back out of it. But they said dystonia has no cure;
she would be paralyzed for life. They said she had an irreversible reaction to the flu shot. (None
of this is in the Johns Hopkins medical notes. Only a physical therapist there said petitioner had
dystonia.)
        In another video,169 dated October 21, 2009, Stan Kurtz is having a conversation with
Michael, one of Dr. Buttar’s employees. Stan Kurtz says many people told him not to come. A
friend of his who is a neurologist who had looked at the videos of petitioner warned him that
petitioner has a psychogenic disorder. His neurologist friend said he was 99.9 percent sure it was
psychogenic. He said Stan Kurtz should not put his reputation and the reputation of Generation
Rescue on the line by associating with petitioner. He said he was telling Stan Kurtz this as a
friend. When Stan Kurtz said petitioner’s heart rate was 120 beats per minute, his friend said
that was an additional condition to the psychogenic disorder.
         Stan Kurtz also told Michael that the former head of the National Institutes of Health,
Bernadine Healy,170 was a friend. She had been mourning the death of her mother when Stan
Kurtz telephoned her. She warned him to stay away from petitioner and not to put Generation
Rescue’s reputation at risk. She said petitioner had an eating disorder, perfect makeup, and was
sitting up. She said Stan Kurtz should get an EEG done to prove petitioner’s condition was not
psychogenic. Stan Kurtz said to Michael that people will marginalize petitioner and say that she
has a rare strange condition. But Stan Kurtz said he would have evidence, get the Johns Hopkins
records, and let the facts speak for themselves.
        The undersigned finds quite remarkable that Stan Kurtz had two friends, a neurologist
and the noted Dr. Bernadine Healy, separately warn him away from associating with petitioner
after seeing the videos of petitioner on national television. Both separately told Stan Gertz that
petitioner has a psychogenic disorder and that if he continued associating with her, he risked his
own and Generation Rescue’s reputations.

168
    The pertinent parts are between minutes 1-5 on Ex. 58, Video #409_0438_01.
169
    The pertinent parts are between minutes 6-13 on Ex. 58, Video #409_0474_02.
170
    Bernadine Healy was the 13th director of NIH, and the first woman to head NIH. She died from brain cancer at
the age of 67 on August 6, 2011. “The Age of Autism anti-vaccine group named her 2008 Person of the Year for
her support of the discredited hypothesis that vaccines are linked to autism.” Bernadine Healy, WIKIPEDIA, THE
FREE ENCYCLOPEDIA , https://en.wikipedia.org/wiki/Bernadine_Healy (last visited April 5, 2019). Dr. Healy gave an
interview on CBS News on May 12, 2008 that the existing vaccine court claims prove vaccines can cause harm.
Leading Dr.: Vaccines-Autism Worth Study, CBS NEWS (May 12, 2008), https://www.cbsnews.com/news/leading-
dr-vaccines-autism-worth-study/.

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        Ironically, Dr. Buttar and petitioner had an agreement that she would be the proponent of
his IV and hyperbaric oxygen therapy treatments on the show 20/20, but she broke her agreement
with him and said on national television that those treatments had not cured her. By rejecting the
“cure” on national television, petitioner continued from 2009 through 2016 with more symptoms,
more doctors, and more drugs, and onto IVIG therapy. She also ended up paying for her
“treatment” with Dr. Buttar because Stan Kurtz refused to pay for it.
        Dr. Steinman and Dr. Lancaster were total opposites in their opinions about whether
petitioner has a lasting physical illness and on the value of the videos filed into evidence. Dr.
Steinman dismissed the videos as less important than meeting petitioner in person right before
the hearing rather than watching, as he put it, a “little screen,” although he did testify that
watching the videos convinced him petitioner had dystonia. Dr. Lancaster, on the other hand,
valued the worth of the videos in giving him an opportunity to observe petitioner’s behavior
directly over many hours. He testified that he was able to stop, go back, view something again,
look at it in detail, and observe petitioner’s gait, speech, and other symptoms. Dr. Lancaster said
that with these videos, he had been able to study petitioner and diagnose her with conversion
disorder with the most detail of any patient he has had.
        What a vast difference in approach in these two neurologic experts. Dr. Steinman was
cavalier in dismissing the value of the videos, except for saying they confirmed his opinion
petitioner had dystonia. He testified he did not think petitioner had dystonia until he saw
petitioner’s weird movements going away when she walked backward in the videos. Tr. at 492-
93. Dr. Steinman questioned how could anyone know that walking backward would make her
flailing go away. Id. at 493. But Dr. Lancaster pointed out that petitioner stated in the videos
that she read on the Internet about dystonia and learned that some dystonia patients could run and
not walk. Then she went and experimented and, each time, it worked. Id. at 633. Dr. Lancaster
stated this was an example of suggestion which worked for petitioner because she thought it
would.
        The undersigned views Dr. Lancaster as the more persuasive expert in this case. Both
experts agreed on one point however: the powerful placebo effect of Dr. Buttar’s suggestion to
petitioner that she would get better to which petitioner had a great response.
       The undersigned finds that more likely than not petitioner has conversion disorder.
              Does petitioner have any physical illness that flu vaccine caused?
        Dr. Steinman testified that someone can have both conversion disorder and a physical
illness. He agreed that Dr. Buttar’s treatment had a placebo effect on petitioner because not only
did the IV (without immunoglobulin) “cure” her POTS, it also “cured” her alleged inability to
walk forward and to speak normally, at least for a time. This leads to the question whether
petitioner had any physical illness other than rhabdomyolysis, recognizing as Dr. Steinman did
that petitioner’s serious medications could have caused her gastroparesis, as Dr. Lancaster said.
         Dr. Steinman constantly shifted in his 10 expert reports about what he thought happened
in this case. Dr. Steinman testified that the case is complex, rare, and difficult, which is true.
The undersigned assumes the many demands on Dr. Steinman’s time and the numerous cases in
which he is petitioners’ expert have made him incapable of focusing until he gets to the hearing
because he mentioned several times at the hearing that “now” that he was at the hearing, he could

                                                227
focus on the issues. His shape-shifting necessitated an extraordinary amount of effort not only
on the parts of respondent’s experts, Dr. Lancaster and Dr. Whitton, to respond to Dr. Steinman’s
ever new theories, but also on the part of the undersigned. So many statements he made at the
hearing, such as he has no proof of any component of flu vaccine that is homologous to
petitioner in molecular mimicry explanation of her autoimmune autonomic neuropathy, set
everyone else in catch-up mode. GBS dropped out of the picture although he had focused on it
as the explanation of everything in several of his reports. Myasthenia dropped out of the picture
when he realized he did not believe petitioner had it. Anti-GAD65 antibody syndrome, stiff
person syndrome, and intestinal pseudo-obstruction dropped out of the picture when he never
testified about them.
      When discovery is not the norm and expert reports replace depositions as in the Vaccine
Program, an expert who can never make up his mind is practically useless. A summary of Dr.
Steinman’s metamorphoses follows.
       Dr. Steinman’s first expert report (Ex. 65) was that flu vaccine caused petitioner’s
rhabdomyolysis followed by serious autoimmune dysautonomia, based on a theory of
inflammation directed to myelin in portions of the autonomic nervous system via molecular
mimicry. He also states that tests of petitioner’s sera indicated she had lupus as well as
dysautonomia. He focuses on how flu vaccine causes GBS. He states petitioner had
autoimmune ganglionopathy.
        Respondent’s initial neurologic expert Dr. Donofrio focuses on the variability on
distraction of petitioner’s symptoms. Ex. B. Dr. Donofrio states Dr. Steinman ignored all the
anomalies in petitioner’s presentation and did not explain how they are consistent with his
diagnosis. Testing did not show petitioner having a significant change in pulse or blood pressure
during up-tilt testing to substantiate the diagnosis of either POTS or orthostatic hypotension. He
states petitioner did not have symptoms that accompany autoimmune ganglionopathy. He denies
petitioner had GBS because she had normal reflexes and normal strength. Dr. Donofrio thinks
petitioner’s viral illness (which Dr. Steinman ignores) is the more likely cause of her
rhabdomyolysis.
        Dr. Steinman’s first supplemental expert report (Ex. 92) clarifies that flu vaccine caused
both petitioner’s rhabdomyolysis and her autonomic autoimmune neuropathy, but that
rhabdomyolysis did not cause her autonomic autoimmune neuropathy. He recognizes that
petitioner will not receive compensation under the Vaccine Program for rhabdomyolysis because
she did not have sequelae of it for more than six months.
        Dr. Steinman’s second supplemental expert report (Ex. 108) states that petitioner had a
variant of GBS which no one recognized and that two treaters (one of whom was at the tertiary
care center Johns Hopkins) denied. Dr. Steinman’s theory for the treaters’ denying petitioner
had GBS was that she did not have classic GBS, i.e., she did not have signs or symptoms of GBS
(areflexia, paralysis, increased protein in her cerebrospinal fluid). He posited that pure dystonia
can be a GBS variant, citing three pieces of medical literature, none of which supports that view.
Finally, on the witness stand, he admitted that autoimmune autonomic neuropathy is at one end
of the spectrum of inflammatory neuropathy and GBS is at the other end of the spectrum of
inflammatory neuropathy. He admits that he infers petitioner had GBS since she had autonomic
dysfunction. Finally, he dispenses at the hearing with GBS altogether.

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        Respondent’s second neurologic expert Dr. Lancaster gives his opinions about the videos
showing petitioner flailing her arm, bopping her head, while walking forward in astasia-abasia
gait. Ex. H. He states that petitioner’s viral infection and racing training were the more likely
cause of her rhabdomyolysis than flu vaccine. He notes that rhabdomyolysis does not damage
the autonomic nervous system or the central nervous system. His summary of the medical
records forms the basis of his opinion that petitioner has conversion disorder.
        Respondent’s virologic and immunologic expert Dr. Whitton points out that when
petitioner had rhabdomyolysis, she did not have any neurologic complaints. Ex. Z. He disagrees
with Dr. Steinman’s use of molecular mimicry in this case because humans have only about 20
different amino acids and it is inevitable a scientist will find identical sequences and multiple
homologies. This response from Dr. Whitton is obviously based on Dr. Steinman’s initial claim
that he found homology, which he denied at the hearing.
        Dr. Steinman’s third supplemental expert report (Ex. 118) states petitioner had three
illnesses, all beginning at the same time (20 days after vaccination) and all with the same
symptoms of fatigue and weakness. The three illnesses are rhabdomyolysis, autonomic
autoimmune neuropathy, and myasthenia gravis. He disputes Dr. Lancaster’s opinion that
petitioner has conversion disorder on the basis that Dr. Lancaster has not met her or treated her.
Dr. Steinman ignores the contemporaneous videos that form the basis of Dr. Lancaster’s opinion.
       Respondent filed Dr. Lancaster’s first supplemental expert report (Ex. RR), noting that
Dr. Sheean’s diagnosis of petitioner having myasthenia gravis was likely incorrect. Dr.
Lancaster states that dystonia is not a symptom of autoimmune autonomic neuropathy because
dystonia comes from the brain and not from the autonomic nervous system.
      Respondent filed Dr. Whitton’s first supplemental expert report (Ex. SS), stating Dr.
Steinman’s theories are jumbled.
        Dr. Steinman’s fourth supplemental expert report (Ex. 141) still discusses GBS as if
petitioner had it. He then comments on the contemporaneous videos. He refuses to comment on
petitioner’s singularly narrow attempt to walk forward with flailing arms. As for her bobbing her
head violently, he states repeatedly that he would need a concomitant EEG and video monitoring
to know if this was an actual seizure. He ignores petitioner’s normal prior EEGs.
        After the hearing, petitioner filed Dr. Steinman’s fifth supplemental expert report (Ex.
181) and respondent filed Dr. Whitton’s second supplemental report (Ex. YYY), stating the same
opinion that petitioner’s negative testing for flu A and B virus antigen on September 12, 2009
did not mean flu vaccine was ineffective.
        Dr. Steinman’s sixth supplemental expert report (Ex. 191) states that petitioner at
Medstar Georgetown University Hospital was noted to have ptosis which confirms she has
myasthenia gravis. He fails to comment on the treating neurologist Dr. Barry’s statement that
petitioner’s ptosis could be overcome with upward gaze, which means petitioner did not have
true ptosis. Dr. Steinman focuses on anti-GAD antibodies as proof that petitioner had an
autoimmune reaction to flu vaccine, although she was not tested for anti-GAD antibodies in
2009.
       Dr. Whitton’s third supplemental expert report (Ex. ZZZ) states Dr. Steinman’s previous
analogy of homologies between flu vaccine and petitioner’s various conditions relied upon Dr.

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Steinman’s error in picking 2010-2011 flu vaccine components instead of 2009-2010 flu vaccine
components. Thus, Dr. Steinman switched from homology to myelin basic protein to homology
to myelin oligodendroglial glycoprotein and 2,3 CNPase. Dr. Steinman also invoked another
protein, i.e., GAD. Dr. Steinman seemed to be favoring a stiff person syndrome diagnosis. Dr.
Whitton attributed petitioner’s elevated GAD antibodies to her receiving IVIG therapy which
contained anti-GAD antibodies from the donors.
        Dr. Lancaster’s second supplemental expert report (Ex. FFFF) says stress may have
triggered petitioner’s stridor during the second day of the hearing. Dr. Lancaster states petitioner
does not have stiff person syndrome. He notes petitioner’s ptosis at Georgetown could be
overcome by looking up, which means it was psychogenic. He also attributed petitioner’s
elevated GAD antibodies to IVIG infusions and wrote petitioner did not have any syndromes
associated with GAD65 antibodies. Dr. Lancaster states it would be entirely unprecedented for
one patient to have so many presumably autoimmune disorders affecting so many distinct areas
of her nervous system, and even more remarkable, that her condition remits completely,
sometimes in seconds, leaving no convincing objective evidence of its existence.
        Dr. Steinman’s seventh supplemental expert report (Ex. 198) states petitioner’s collapse
and stridor in the hearing room the second day of the hearing proves she has myasthenia gravis.
He insists her anti-GAD antibody test results prove she has an ongoing immunologic process.
He says the anti-GAD antibodies explain her having myasthenia gravis, stiff person syndrome,
intestinal pseudo-obstruction, and autonomic neuropathy.
       Dr. Steinman’s eight supplemental expert report (Ex. 206) says all of petitioner’s
problems are related to anti-GAD antibodies.
        Dr. Steinman’s ninth supplemental expert report (Ex. 208) says flu vaccine likely
triggered petitioner’s autoimmunity to GAD.
        Dr. Whitton’s fourth supplemental report (Ex. MMMM) says petitioner had much lower
anti-GAD antibodies than someone with stiff person syndrome would have. He disagrees with
Dr. Steinman’s thesis that homology proves molecular mimicry occurred. Dr. Whitton states
proteins fold into complex three-dimensional structures and the relevant part of the host protein
may be hidden inside the fold and therefore inaccessible to antibodies.
        Dr. Lancaster’s third supplemental report (Ex. QQQQ) states that none of the disorders
Dr. Steinman says petitioner has (myasthenia gravis, autonomic failure, and dystonia) accounts
for petitioner’s most prominent symptoms in the weeks and months after her flu vaccination.
        Petitioner had a physical illness rhabdomyolysis whose cause could be the viral infection
that Dr. Steinman ignores because he does not know what kind of virus petitioner had in early
September 2009. In addition, petitioner was training for a race and exercise can provoke
rhabdomyolysis, particularly in someone who was not yet over her upper respiratory infection.
As for vagus nerve damage, petitioner has been diagnosed with orthostatic hypotension due to
volume depletion, i.e., she was not drinking enough fluids, causing her to faint. This has nothing
to do with flu vaccination. Her doctors note this connection of vasovagal syncope with
dehydration, and also note she was not orthostatic when hydrated:

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       1. Dr. Jeffrey Luy, a cardiologist, wrote on September 18, 2009 that petitioner’s syncope
          was “probably vasovagal due to some relative element of dehydration.” Med. recs.
          Ex. 51, at 25.
       2. Dr. Mannan, attending physician in Inova Fairfax Hospital, wrote on September 29,
          2009 that she had orthostatic hypotension due to volume depletion. Med. recs. Ex.
          44, at 13. Her hypotension improved with IV hydration. Id.
       3. Dr. Farhad Zangeneh, an endocrinologist, wrote on May 24, 2010 that petitioner’s
          blood pressure when she was sitting and standing was nearly identical. He wrote she
          did not have orthostatic hypotension. Med. recs. Ex. 43, at 29.
       4. Dr. Yan-Go, a neurologist specializing in autonomic neuropathy, wrote on August 24,
          2010 that petitioner was not orthostatic. Med. recs. Ex. 18, at 3. She also wrote on
          September 14, 2010 that petitioner did not have serious pure autonomic failure or
          degenerative dysautonomia. Id. at 6.
       5. Dr. Wilkinson, a cardiologist, wrote on February 3, 2011 that petitioner was taking
          very potent medications and did not have unusual syncope. Med. recs. Ex. 12, at 1.
        Dr. Steinman and Dr. Lancaster agreed on six medical points: (1) that a technician’s
interpretation of a SPECT scan to show that petitioner had abnormal cerebral perfusion was
wrong; (2) that petitioner’s drugs (particularly Sandostatin) may have caused her gastroparesis;
(3) that Dr. Buttar’s eight-hour IV infusions of water and glucose/saline had a placebo effect in
“curing” albeit temporarily petitioner’s alleged POTS, alleged dystonia, and alleged foreign
accent syndrome; (4) that there is no such diagnostic entity as “Raynaud’s of the brain,” (5) that
hyperbaric oxygen therapy and chelation have only limited utility and no utility whatsoever for
petitioner’s complaints; and (6) that petitioner does not have Lambert-Eaton Syndrome (one of
the diagnoses Dr. Sheean posited as a diagnosis for petitioner). That petitioner in early
September 2009 had rhabdomyolysis is not an issue. It is also not an issue that petitioner
recovered quickly from rhabdomyolysis.
        As is obvious from the description of Dr. Steinman’s constantly changing analysis of
petitioner’s purported illnesses, he never had a grasp of this case and that is not only because the
case is complex. He never focused on it, he brushed away the many indications of conversion
disorder and, finally, at hearing, admitted on cross-examination that now that he was focused on
the case, his only diagnoses were autoimmune autonomic neuropathy and vagus nerve damage.
He flitted through 10 expert reports with constant changes of his opinion. Then, in his
testimony, he changed his mind again.
        Dr. Steinman’s frequent carping at Dr. Whitton that he is not licensed to practice
medicine in the United States is irrelevant since Dr. Whitton is a researcher, not a clinician. Dr.
Whitton’s purpose at the hearing was to counter Dr. Steinman’s age-old attempt to shoehorn
molecular mimicry into every causation in fact case. As for lack of board certification, although
Dr. Steinman is not board certified in immunology, he testifies not only as an expert neurologist
(and he is board certified in neurology) but also as an expert immunologist. Respondent did not
object to his expertise in immunology. Dr. Sheean, for whom Dr. Steinman provided copious
encomiums, is not board certified in anything.
       Dr. Steinman denied at the beginning of his testimony that he is an advocate and that he
would not delve into the law. He pictured himself as just a neutral physician whose purpose was
to educate the special master about the significance of the medical facts of the case. Would that

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were so. Dr. Steinman is indeed an advocate. He cited legal decisions in more than one of his
expert reports. He cherry picked among the evidence to support the conclusion he wanted the
special master to reach. But he never completely focused on the issues until the hearing when
his numerous other vaccine cases and professional chores were not before him. He even mistook
the date of the flu season he was checking to note the components of the 2009 flu vaccine
petitioner received as part of his analysis of molecular mimicry, picking the 2010-2011 flu
season instead of the 2009-2010 flu season. That made numerous reports he wrote erroneous.
        Dr. Steinman had a valid concern about participating in this case because of the presence
of Dr. Buttar and petitioner’s participation in numerous public media. The undersigned can
appreciate Dr. Steinman’s concern. He has an extraordinary list of accomplishments in his CV.
But accomplishments are not enough when he squandered his own time and that of respondent’s
experts, both counsel, and the special master by pulling out various diagnoses and analyses like
rabbits from a hat without grasping the facts of this complex case.
        It is problematic when an expert witness is at war with himself, proposing diagnoses and
then negating them, eventually ending up with pure speculation that because petitioner had a
higher than normal measure of GAD65 in 2015 that GAD associated-antibody disease is the
explanation for all her many illnesses going back six years to her 2009 flu vaccination when no
one tested her for GAD65 antibodies. Yet, he had bursts of honesty through the haze of his
advocacy when he agreed with Dr. Lancaster on the six above-mentioned medical points. He
admitted, “We’re not saying that it’s GBS here, we should make that clear.” Tr. at 430.
        Consequently, because of Dr. Steinman’s many foibles and fumbles, the undersigned
found herself relying exclusively on Dr. Lancaster who was methodical, precise, and dedicated to
sticking to the record. His opinion and the opinion of Dr. Donofrio are consistent. Dr. Donofrio
wrote that petitioner did not have dystonia, dysautonomia, POTS, orthostatic hypotension, or
GBS. Ex. B, at 7-8. He believed petitioner probably had a viral illness in early September 2009
which, together with her regimented exercise while training for a race, caused her
rhabdomyolysis. Id. at 8.
       Dr. Lancaster cogently explained how petitioner’s medical records belie her having a
physical illness, other than rhabdomyolysis. His opinion is consistent with the opinions of the
numerous neurologists petitioner saw at Inova Fairfax, Inova Loudon, and Johns Hopkins. Dr.
Lancaster’s opinion is consistent with the conclusion of the early treating neurologist, Dr.
Stephenson. All these neurologists saw petitioner in the few months after her vaccination and
would know best if she were manifesting any neurologic illness. They uniformly denied she had
any neurologic illness. Dr. Steinman ignored these records. Dr. Lancaster paid attention to these
records, and medically interpreted in great detail what the contemporary videos conveyed. He
was a straight arrow from start to finish.
         The undersigned also values Dr. Whitton’s explanation that Dr. Steinman’s reliance on
homology to explain how flu vaccine caused whatever Dr. Steinman decided at the moment she
had was oversimplistic and does not encompass the complexity of protein folding in three
dimensions. It was respondent’s expert, not petitioner’s expert, who recognized Dr. Steinman
initially analyzed the components of the 2010-2011 flu season trivalent flu vaccine, not the 2009-
2010 flu season trivalent flu vaccine (the flu vaccine petitioner received was on August 23,
2009), an example of Dr. Steinman’s carelessness. The undersigned finds Dr. Whitton’s
testimony compelling.
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        What is most perplexing of all the many twists and turns of Dr. Steinman’s opinions is
his putting dystonia within the category of the autonomic nervous system. Dr. Lancaster
persuasively testified that dystonia is not an autonomic nervous system malfunction, but instead
is a problem in the central nervous system. Dr. Lancaster said the medical community accepts
this understanding of dystonia. Dr. Steinman based his erroneous opinion on four mistakes he
made: (1) that petitioner manifested dystonia (Dr. Steinman’s supposed “aha” moment when he
saw the videos); (2) that dystonia is a problem of the autonomic nervous system; (3) that
petitioner had dysautonomia of which dystonia is a part; and (4) that flu vaccine caused all these
problems, none of which she had. These mistakes negate Dr. Steinman’s credibility.
        The word Dr. Steinman kept emphasizing in his testimony as an explanation for his new
analysis of the case at the hearing was “focus.” In other words, by flying from California to
Washington, DC, going to the hotel, meeting petitioner for the first time, and talking with
petitioner’s counsel, he did not have any distractions from his many other activities. Now he
could focus on the case. The undersigned recognizes that Dr. Steinman is a very busy man in his
professional life (see supra, nn.121-25 and accompanying text), and that he is or has been
petitioner’s expert in many vaccine cases.171 However, his responsibility to petitioner,

171
   This is a listing of decisions published on Westlaw in which Dr. Steinman was petitioner’s expert: Abbott ex. rel.
Bunch v. Sec’y of HHS, No. 99-497V, 2010 WL 3186269 (Fed. Cl. Spec. Mstr. June 28, 2010); Ricci v. Sec’y of
HHS, No. 99-524V, 2011 WL 2260391 (Fed. Cl. Spec. Mstr. May 16, 2011), aff’d, 101 Fed. Cl. 385 (2011);
Contreras v. Sec’y of HHS, No. 05-626V, 2012 WL 1441315 (Fed. Cl. Spec. Mstr. Apr. 5, 2012), vacated, 107 Fed.
Cl. 280 (2012), 2013 WL 6698382 (Fed. Cl. Spec. Mstr. Nov. 19, 2013), vacated, 116 Fed. Cl. 472 (2014), 2014
WL 8098606 (Fed. Cl. Spec. Mstr. Oct. 24, 2014), aff’d, 121 Fed. Cl. 230 (2015), vacated, 844 F.3d 1363 (Fed. Cir.
2017); Broekelschen v. Sec’y of HHS, No. 07-137V, 2009 WL 440624 (Fed. Cl. Spec. Mstr. Feb. 4, 2009), aff’d, 89
Fed. Cl. 336 (2009), aff’d, 618 F.3d 1339 (Fed. Cir. 2010); Torday v. Sec’y of HHS, No. 07-372V, 2011 WL
2680687 (Fed. Cl. Spec. Mstr. June 20, 2011); Veglia v. Sec’y of HHS, No. 02-397V, 2009 WL 515407 (Fed. Cl.
Spec. Mstr. Feb. 10, 2009); Smith v. Sec’y of HHS, No. 08-864V, 2016 WL 2772194 (Fed. Cl. Spec. Mstr. Apr. 18,
2016); McCulloch v. Sec’y of HHS, No. 09-293V, 2015 WL 3640610 (Fed. Cl. Spec. Mstr. May 22, 2015); Brown
v. Sec’y of HHS, No. 09-426V, 2011 WL 5029865 (Fed. Cl. Spec. Mstr. Sept. 30, 2011); Tetlock v. Sec’y of HHS,
No. 10-56V, 2018 WL 823420 (Fed. Cl. Spec. Mstr. Jan. 19, 2018); Daniel v. Sec’y of HHS, No. 10-745V, 2016
WL 7785955 (Fed. Cl. Spec. Mstr. Dec. 21, 2016); Perez v. Sec’y of HHS, No. 10-659V, 2015 WL 9483680 (Fed.
Cl. Spec. Mstr. Dec. 8, 2015); Dillon v. Secy of HHS, No. 10-850V, 2013 WL 33745900 (Fed. Cl. Spec. Mstr. June
25, 2012), aff’d, 114 Fed. Cl. 236 (2014); B.A. v. Sec’y of HHS, No. 11-51V, 2019 WL 460941 (Fed. Cl. Spec.
Mastr. Jan. 10, 2019); Musto v. Sec’y of HHS, No. 11-801V, 2017 WL 1150797 (Fed. Cl. Spec. Mstr. Mar. 2,
2017); Vigliotti v. Sec’y of HHS, No. 12-281V, 2019 WL 948365 (Fed. Cl. Spec. Mstr. Jan. 29, 2019); Auch v.
Sec’y of HHS, No. 12-673V, 2017 WL 1718783 (Fed. Cl. Spec. Mstr. Apr. 5, 2017); Guerrero v. Sec’y of HHS, 12-
689V, 124 Fed. Cl. 153 (2015); Giannetta v. Sec’y of HHS, No. 13-215V, 2017 WL 4249946 (Fed. Cl. Spec. Mstr.
Sept. 1, 2017); Taylor v. Sec’y of HHS, No. 13-700V, 2018 WL 6291355 (Fed. Cl. Spec. Mstr. Oct. 30, 2018);
Harrington v. Sec’y of HHS, No. 14-43V, 2018 WL 4401976 (Fed. Cl. Spec. Mstr. Aug. 14, 2018); Kukreja v. Sec’y
of HHS, No. 14-104V, 136 Fed. Cl. 431 (Dec. 22, 2017); Quance v. Sec’y of HHS, No. 14-271V, 2018 WL
7017750 (Fed. Cl. Spec. Mstr. Dec. 13, 2018); Pentcholov v. Sec’y of HHS, No. 14-414V, 2016 WL 3197389 (Fed.
Cl. Spec. Mstr. Apr. 29, 2016); Rolshoven v. Sec’y of HHS, No. 14-439V, 2018 WL 1124737 (Fed. Cl. Spec. Mstr.
Jan. 11, 2018); Rosof v. Sec’y of HHS, No. 14-766V, 2017 WL 1649802 (Fed. Cl. Spec. Mstr. Mar. 31, 2017); S.B.
v. Sec’y of HHS, No. 14-918V, 2018 WL 6819552 (Fed. Cl. Spec. Mstr. Nov. 28, 2018); Quackenbush-Baker v.
Sec’y of HHS, No. 14-1000V, 2018 WL 1704523 (Fed. Cl. Spec. Mstr. Mar. 14, 2018); Forrest v. Sec’y of HHS,
No. 14-1046V, 2019 WL 925495 (Fed. Cl. Spec. Mstr. Jan. 28, 2019); D’Tiole v. Sec’y of HHS, No. 15-85V, 2017
WL 5379195 (Fed. Cl. Spec. Mstr. Sept. 19, 2017), aff’d, 132 Fed. Cl. 421 (2017), aff’d,726 Fed. Appx. 809 (Fed.
Cir. 2018); Chinea v. Sec’y of HHS, No. 15-95V, 2019 WL 1873322 (Fed. Cl. Spec. Mstr., Mar. 15, 2019), mot. for
rev., (Apr. 15, 2019); Crosby v. Sec’y of HHS, No. 15-556V, 2017 WL 7101151 (Fed. Cl. Spec. Mstr. Aug. 29,
2017); Arnold v. Sec’y of HHS, No. 15-534V, 2017 WL 3165486 (Fed. Cl. Spec. Mstr. June 22, 2017); Winterfeld
v. Sec’y of HHS, No. 15-933V, 2018 WL 2225178 (Fed. Cl. Spec. Mstr. Mar. 9, 2018 (Fed. Cl. Spec. Mstr. Mar. 9,
2018); Franco v. Sec’y of HHS, No. 16-99V, 2018 WL 4141292 (Fed. Cl. Spec. Mstr. July 31, 2018); Meadows v.

                                                        233
respondent, both counsel, and the undersigned is to give his full attention to and focus on the
facts of a case in which he voluntarily agrees to be an expert. To wait until he is actually at the
hearing in order to focus is inexcusable. Granted, this is a complex case. But its complexity
demands more, not less, of his time and attention. To make respondent, both counsel, and the
undersigned careen along the many tracks of his various positions, all of which Dr. Steinman
forcefully held until he changed his mind, is unacceptable and lessens any credibility he may
have had because of his impressive CV.
        When Dr. Steinman was in his pro-myasthenia gravis mode, he supported petitioner’s
having the disease because a tiny minority of patients have negative results on all the critical
tests for myasthenia gravis. But the Vaccine Act, § 300aa-13(a)(1), and the Federal Circuit’s
interpretation of it in Grant require affirmative proof by preponderant evidence. 956 F.2d at
1149.
        The undersigned recognizes that Dr. Steinman abandoned his pro-myasthenia gravis
mode when he responded to Ms. Walters’ question asking him what precise conditions petitioner
had and he answered autoimmune autonomic neuropathy and vagus nerve damage. Even if
petitioner did have autoimmune autonomic neuropathy, which considering the evidence in the
videos, Dr. Lancaster’s interpretation of the videos, and petitioner’s negative medical
examinations, is seriously in doubt, Dr. Steinman’s explanation of how flu vaccine caused
petitioner’s autoimmune autonomic neuropathy is based on a fallacy.
        Dr. Steinman based his causation opinion on a theory that flu vaccine, containing protein
homologies to myelin basic protein, resulted in molecular mimicry that caused petitioner
autoimmune autonomic neuropathy. Dr. Lancaster said this mechanism does not exist. Attacks
on myelin, if they occur, do not select solely the autonomic nervous system. Dr. Lancaster said
that he is unaware of evidence showing autoimmune autonomic neuropathy has anything to do
with demyelination of the autonomic nervous system. He denied there is such a disease entity as
a selective autonomic neuropathy as compared to an autonomic neuropathy that is secondary to
and associated with GBS, a demyelinating peripheral neuropathy. (That certainly explains why
Dr. Steinman labored so strenuously to prove petitioner had GBS so as to link her putative
autonomic neuropathy to it.)
        Moreover, Dr. Whitton explained, once respondent’s counsel pointed out to Dr. Steinman
at the hearing Dr. Steinman’s error in selecting the wrong flu season to analyze the components
of the flu vaccine that petitioner received, Dr. Steinman’s new theory that Brisbane H3N2 virus
induces a T-cell response has never been proved. In addition, Dr. Whitton testified Brisbane
H3N2 is not an immune epitope capable of triggering an immune response. The Lei paper (Ex.
OOO) showed that humans and mice who received 2009 H1N1 vaccine, even though eight of the
humans reacted to the vaccine with GBS, did not have antiganglioside antibodies. That vitiates
Dr. Steinman’s attempt to explain how petitioner’s 2009 trivalent flu vaccine caused whatever
condition he was attempting to prove by reference to the Nachamkin article (Ex. LLL and Ex.
146) which detected antiganglioside antibodies in mice. This does not of course mean petitioner

Sec’y of HHS, No. 16-861V, 2018 WL 6292565 (Fed. Cl. Spec. Mstr. Oct. 31, 2018); Zumwalt rel. L.Z. v. Sec’y of
HHS, No. 16-994V, 2018 WL 6975184 (Fed. Cl. Spec. Mstr. Nov. 27, 2018); Ahler v. Sec’y of HHS, No. 16-
1147V, 2018 WL 2224896 (Fed. Cl. Spec. Mstr. Apr. 9, 2018); Matthaes v. Sec’y of HHS, No. 16-1266V; 2018 WL
4390644 (Fed. Cl. Spec. Mstr. July 30, 2018).

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had GBS which is the subject of both the Nachamkin and Lei articles. She did not have GBS.
What we are left with is a faulty explanation of how flu vaccine caused a purported autonomic
neuropathy that is really conversion disorder.
        Except for rhabdomyolysis, viral infection, and possibly gastroparesis, the undersigned
finds that petitioner failed to prove she had the diseases she either alleged or were mentioned in
the medical records: seizures, GBS, dystonia, dysautonomia, autonomic autoimmune
neuropathy/autonomic immune ganglionopathy, neurocardiogenic syncope, vagal nerve damage,
optic neuritis, myasthenia gravis, mercury poisoning, MS, lupus, pseudo-intestinal obstruction,
poor cerebral perfusion, POTS, anti-GAD antibody syndrome, and stiff person syndrome.
        Her viral infection in early September is well established in the medical records with the
standard symptoms of nasal congestion, fever, cough, phlegm. Her rhabdomyolysis is well-
associated with viral infection and exercise. The two case reports petitioner filed that theorize
vaccines may cause rhabdomyolysis are insufficient proof. Crutchfield v. Sec’y of HHS, No. 09-
39V, 2014 WL 1665227 (Fed. Cl. Spec. Mstr. Apr. 7, 2014), aff’d, 125 Fed. Cl. 251 (2014). As
Dr. Steinman recognized in his reports, petitioner recovered from rhabdomyolysis quickly and
would not receive compensation from the Vaccine Program even if flu vaccine played a role in
causing it. 42 U.S.C. § 300aa-11(c)(1)(D)(i). The undersigned finds that flu vaccine did not
cause petitioner’s rhabdomyolysis.
        Both Dr. Steinman and Dr. Lancaster thought that petitioner’s drugs, particularly
Sandostatin, caused her gastroparesis. On August 26, 2010, which is 11 months after petitioner’s
flu vaccination, Dr. Ghassemi, a gastroenterologist, determined by testing petitioner that she did
not have a motility disorder. Med. recs. Ex. 18, at 8-9. The undersigned finds that the drugs
petitioner took caused her gastroparesis. Dr. Steinman tried to do an end run around this gap of
time between vaccination and gastroparesis diagnosis by saying if petitioner did not have a
vaccine injury, she would not have had to take the potent drugs. But the undersigned finds she
did not have a vaccine injury and rejects Dr. Steinman’s attempt to create a causative link.
        The undersigned finds that petitioner had conversion disorder and not a vaccine related
injury. Thus, petitioner has failed to make a prima facie case that flu vaccine caused her any
condition which she alleged. Regarding an Althen analysis, per the Federal Circuit’s holding in
Broekelschen, an Althen analysis is unnecessary when petitioner does not have the disease
petitioner alleged. See Broekelschen, 618 F.3d at 1346-49.
                                                 CONCLUSION
         The undersigned DISMISSES this case for failure to prove causation in fact.
       In the absence of a motion for review filed pursuant to RCFC Appendix B, the clerk of
the court is directed to enter judgment herewith.172

172
    Pursuant to Vaccine Rule 11(a), entry of judgment can be expedited by each party, either separately or jointly,
filing a notice renouncing the right to seek review.

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IT IS SO ORDERED.

Dated: May 24, 2019         /s/ Laura D. Millman
                               Laura D. Millman
                                Special Master

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