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[ "Available Options\n\nPLEASE NOTE - THE ICONIC IS UNABLE TO SHIP THIS PRODUCT TO NEW ZEALAND\n\nThe North Face Men's Avalon Jogger Pants are perfect for both the trail and your downtime. ", "The pants are cut to form a stylish tapered leg and are outfitted with the brand's FlashDry™ and Dryvent™ technology to keep you cool and dry.", "\n\nOur model is wearing size large pants, and usually takes a size medium/32 pants. ", "He is 6’1” (185cm) tall with a 43” (109cm) chest and a 33 1/2” (85cm) waist." ]

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[ "Q:\n\nSelect on CLOB XML DB2\n\nI have this data as CLOB field in DB2. ", "I am converting the data to char using cast: \nSELECT CAST(CLOBColumn as VARCHAR(32000))\nFROM Schema.", "MyTable;\n\nHere is how the result XML comes out from the above: \n<TreeList TreeNo=\"ABC\">\n <Tree ErrorCode=\"INVALID_TREE\" ErrorDescription=\"Tree doesn’t exist.\"", " TreeID=\"123456\"/>\n <Tree ErrorCode=\"INVALID_TREE\" ErrorDescription=\"Tree doesn’t exist.\"", " TreeID=\"1234567\"/>\n</TreeList>\n\nAnd this is how I expect my output \n|TreeNo | TreeID | ErrorCode | ErrorDescription\n|ABC | 123456 | INVALID_TREE | Tree doesn’t exist\n|ABC | 1234567 | INVALID_TREE | Tree doesn’t exist\n\nHow do I achieve this?", "\n\nA:\n\nYou need to use the XMLTABLE function which allows to map XML data to a table. ", "You can pass in XML-typed data and it works if you directly parse the CLOB to XML. ", "The SELECT would look like the following (you get the idea):\nSELECT x.*\nFROM schema.mytable, XMLTABLE(\n '$CLOBColumn/TreeList'\n COLUMNS \n TreeNo VARCHAR(10) PATH '@TreeNo',\n TreeID INT PATH 'Tree[@TreeID]',\n ...\n) AS x\n;\n\n" ]

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[ "What if White Women Got the “Can I Touch Your Hair?” ", "Question All the Time\n\nIn a multi-slide feature for NaturallyCurly.com, cartoonist Tall N Curly has re-imagined a world where curly hair is the mainstream, and straight hair is ‘exotic’. ", "Click here to check out the whole thing. ", "And we do recommend it because it’s pretty amazing!", "\n\nBut it’s this image that has sparked a conversation online:\n\nSeeing the tables turned has generated discussion on whether the infamous ‘hair touching’ question is appropriate or fair. ", "What do you think ladies?" ]

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[ "Q:\n\nHow to add SPF1 record properly on GoDaddy\n\nI setup postfix and mailx (Fedora25) for sending mail through a contact form on my website, and I am looking to add SPF1 and DKIM signature for increase my validity, but I'm having a hard time sorting out how to add the SPF record to my DNS Zone file on GoDaddy.", "\nI already had a Google verification TXT record, so I can't simply add the SPF. ", "I found some instructions to add multiple. ", "There are warnings about adding multiple entries, but leading research had me noting that separating them with a space encased in quotes should work, so I ended up trying:\n\n\"google-site-verification=9s8d7f6h98e5hd5rn\" \"v=spf1 a mx include:adammackintosh.net ~all\" \n\nI then ran an SPF checker tool and it showed the updated record but said 'no valid SPF found' (kitterman tool).", "\nCan anyone help me add this through GoDaddy? ", "\n\nA:\n\nDefine both; this is a friend's list of TXT records. ", " His email got migrated to google just fine, and the SPF one works (both in testing, and according to one of openspf.org's recommended testing tools):\n[me@risby ~]$ dig txt theonlinedoor.com\n[...]\n;; QUESTION SECTION:\n;theonlinedoor.com. ", " IN TXT\n\n;; ANSWER SECTION:\ntheonlinedoor.com. ", " 3600 IN TXT \"v=spf1 include:_spf.google.com ?", "all\"\ntheonlinedoor.com. ", " 3600 IN TXT \"google-site-verification=8MWNW2EeagfeQ1ea4OSG1-fq0yI9M5HGDCdH0y8aSfM\"\n\nThough I will add in passing my customary grumpy note that an SPF record that doesn't end -all is functionally useless, and you should not bother.", "\n\n" ]

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[ "Q:\n\nWord/phrase/allusion for spreading false intel to catch a mole\n\nIf I want to find the leak in my agency, I tell twenty people twenty stories and wait to see which emerges.", "\nIf I want to find out who's selling my contact info to spammers, I give every company a different email of mine and check which one gets the spam.", "\nIf I want to know who's blackmailing people, I tell each suspect about a different potential victim and watch to see who gets blackmailed next.", "\nHow can I refer to this strategy without explaining it?", "\n\nA:\n\nDisinformation \n\"Disinformation is intentionally false or inaccurate information that is spread deliberately.[1] It is an act of deception and false statements to convince someone of untruth. ", "Disinformation should not be confused with misinformation, information that is unintentionally false.\" ", " Quoted from Wikipedia\nThere was an elaborate program of disinformation in WWII to convince the Germans that the invasion would not be at Normandy, but at Calais. ", " If you like science fiction, see Connie Willis \"All Clear\", the sequel to \"Blackout\". ", " Strange, I agree to list SF as a reference, but her depiction of WWII in London and key places in England was extraordinarily well researched. ", " \n\n" ]

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[ "Shape-controlled synthesis of Sn-doped CuO nanoparticles for catalytic degradation of Rhodamine B.\nThe uniform Sn-doped CuO nanoparticles were synthesized by a simple solution method at a low temperature. ", "The prepared samples were investigated by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), electron microscopy techniques (HRSEM, HRTEM, SAED, STEM and EDS elemental mapping), atomic force microscopy (AFM), UV/Vis spectroscopy, nitrogen physisorption (BET) and by evaluation of the catalytic activity on the degradation of Rhodamine B. The tin doping had a considerable influence on the morphology of CuO. The gradual narrowing of the particles morphology in the crystallographic [010] direction was observed with increasing the dopant concentration. ", "The plate-like, rectangularsquare and rod-like CuO nanoparticles were obtained. ", "The mechanism of a crystal growth of CuO associated with doping is proposed. ", "The tin doping also affected the structural and optical properties of CuO. Increasing the amount of a dopant led to a red-shift of a band gap from 1.33 to 1.18eV. The incorporation of tin into the structure of copper oxide was confirmed by XRD and distribution of tin mapped by EDS analysis. ", "The good catalytic properties of the as-prepared doped material were demonstrated by the enhanced catalytic removal of Rhodamine B in the presence of H2O2. ", "The undoped CuO nanosheets reached only 24% efficiency in the removal of Rhodamine B within two hours. ", "The best result exhibited CuO_050Sn sample containing 4at.% of tin and the degradation of Rhodamine B reached 99% within the same time. ", "We have demonstrated a simple, scalable process for the preparation of catalytically very active Sn-doped CuO nanoparticles with varying properties." ]

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[ "[Percutaneous endoscopic discectomy in the treatment of patients with degenerative diseases of the lumbosacral spine].", "\nModern surgery uses a variety of treatments for spine pathology. ", "Endoscopic techniques have become particularly popular across the world over the past decade. ", "In this article, we summarize our experience and analyze the immediate and long-term results of surgical treatment of lumbar disc herniation using a percutaneous fully endoscopic technique for removing the herniated intervertebral disc, which is new for Russian medical practice. ", "to evaluate the efficacy of percutaneous endoscopic discectomy in the treatment of herniated lumbar discs in patients with radicular pain syndrome. ", "We conducted a cohort retrospective study that included 69 patients who underwent herniated disc removal using the percutaneous endoscopic technique. ", "Surgery was performed through two approaches: the intralaminar approach was used in 44 patients, and the transforaminal approach was used in 25 patients. ", "To assess the efficacy of surgery, we used a visual analogue scale (VAS) of pain: the intensity of local pain (VAS1) and the intensity of radicular pain (VAS2). ", "Changes in the quality of life and ability to work were assessed by using the Oswestry scale; patient satisfaction with treatment was assessed by using the MacNab scale. ", "The mean follow-up period after surgery was 24 months. ", "An analysis of changes in the pain syndrome (VAS1 and VAS2) before surgery and in the early postoperative period demonstrated a significant regression of pain regardless of the approach type (r=0.25). ", "Patients' survey (MacNab scale) in the long-term postoperative period revealed no unsatisfactory results; excellent, good, and satisfactory results were observed in 21 (30%), 32 (46%), and 16 (24%) patients, respectively. ", "Percutaneous endoscopic discectomy is an effective surgical treatment for degenerative diseases of the lumbosacral spine, providing excellent and good treatment outcomes in most operated patients." ]

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[ "Q:\n\nShould I be worried about cassandra hints in case of dc downtime?", "\n\nI will soon be expanding to 2 dc's from 1 and thus I am a little worried about what happens when while using LOCAL_QUORUM I have one of the dc's that is down.", "\nLets say I have 2 dc's: dc1 and dc2. ", "Keyspace A will be replicated along d1 and d2 both.", "\nNow how large will hints be a problem in case where I am unable to replicate my writes to dc2 when using local quorum to write in dc1. ", "I know that the writes will be acknowledged as a success since using local quorum but since the data needs to be replicated so that the same can be read in dc2 for analytical purposes, would the build up of cassandra hints be a problem?", "\n\nA:\n\nThis really depends on amount of writes, and how you want to recover from downtime, and how big downtime could be:\n\nCassandra sends writes to all nodes anyway - LOCAL_* just says that acknowledgement should come from local DC\nIf another DC is down, hints are written to disk, and replayed after DC is up\nIf DC will be down for longer than max_hint_window_in_ms, then you'll need to perform repair anyway, so replaying hints will just add an additional load to servers\n\nIf you expect that DC will be always down for longer period of time, you may disable writing of hints for another DC via hinted_handoff_disabled_datacenters setting - but you'll need to perform repair after DC is back.", "\nP.S. I see the datastax tag - does this mean that you're using DSE? ", "If yes, what version? ", "Because in DSE 6.x, NodeSync can catch up with missing data.", "\n\n" ]

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[ "Patrulla norte\n\nPatrulla norte is a 1951 Argentine film.", "\n\nCast\n\nExternal links\n \n\nCategory:1951 films\nCategory:Argentine films\nCategory:Spanish-language films\nCategory:Argentine black-and-white films" ]

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[ "Mary L. Shade\n\nShe was born on Thursday, July 16, 1925, in Pueblo, CO, a daughter of the late Frank and Anna Chular Trenchak.", "\n\nShe was a graduate of Central High School Pueblo, CO.", "\n\nShe was a floor worker for the former Amy Sportswear, Valley View, prior to her retirement.", "\n\nShe was a member of St. Andrew's United Methodist Church, Valley View; where she was a member of the United Methodist Women's Group and a former custodian.", "\n\nMary loved the Phillies and all of the Tri-Valley Sports Teams.", "\n\nShe was preceded in death by her husband, Clair G. Shade in 1995. ", "She was also preceded in death by a brother, Frank Trenchak; and two sisters, Helen Hunsaker and Jay Krasovic.", "\n\nShe is survived by two sons, Mike L. Shade and his wife Terry of Warfordsburg, and Marty L. Shade of Valley View; a grandson, Danny True of Hagerstown, MD; a granddaughter, Kelly True of Hagerstown, MD; and several nieces and nephews.", "\n\nFuneral services were held at St. Andrew's United Methodist Church, Valley View, on Wednesday, Nov. 7, with Rev. Duane Bardo officiating. ", "Burial was in St. Andrew's Cemetery, Valley View.", "\n\nMemorial contributions can be made to St. Andrew's United Methodist Church, P.O. Box 221, Valley View, PA 17983.", "\n\nBuffington-Reed Funeral Home, Valley View, is in charge of arrangements.", "\n\nWe welcome user discussion on our site, under the following guidelines:\n\nTo comment you must first create a profile and sign-in with a verified DISQUS account or social network ID. ", "Sign up here.", "\n\nComments in violation of the rules will be denied, and repeat violators will be banned. ", "Please help police the community by flagging offensive comments for our moderators to review. ", "By posting a comment, you agree to our full terms and conditions. ", "Click here to read terms and conditions." ]

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[ "Müncheberg (Mark) station\n\nMüncheberg (Mark) station is a railway station in the municipality of Müncheberg in the Märkisch-Oderland district of Brandenburg, Germany. ", "It is served by the line .", "\n\nReferences\n\nCategory:Railway stations in Brandenburg\nCategory:Railway stations opened in 1867\nCategory:1867 establishments in Prussia\nCategory:Buildings and structures in Märkisch-Oderland" ]

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[ "Main menu\n\nPost navigation\n\nSun final regular-season top 10\n\nBefore I release the rankings, I have to admit that I had no idea how to rank the four Baseline League teams. ", "They have alternately beaten and lost to each other and the two that were unranked last week turned out to be the co-champions of the league after last week’s results.", "\n\nI couldn’t not rank them, nor could I not rank Rancho Cucamonga and Upland. ", "So after hemming and hawing, I decided to rank them in the 5-8 spots in the order that they finished in league play. ", "So my apologies to Kaiser and Rim of the World for dropping out of the polls through no fault of their own. ", "Guess I have to make this a top 12 next year." ]

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[ "Protonation-Driven Membrane Insertion of a pH-Low Insertion Peptide.", "\nThe pH-low insertion peptide (pHLIP) inserts into membranes and forms a transmembrane (TM) α-helix in response to slight acidity, and has shown great potential for cancer diagnosis and treatment. ", "As a lead, pHLIP is challenging to optimize because the mechanism of its pH-dependent membrane interactions is not completely understood. ", "Within pHLIP there are multiple D/E residues which could sense the pH change, the particular role played by each of them in the protonation-driven insertion process is not clear. ", "The precise location of the TM helix within the pHLIP sequence is also unknown. ", "In this work, solid-state NMR spectroscopy is used to address these central questions. ", "Tracing backbone conformations revealed that the TM helix spans from A10 to D33 with a break at T19 to P20. ", "Residue-specific pKa values of D31, D33, D25, and D14 were determined to be 6.5, 6.3, 6.1, and 5.8, respectively, and define the sequence of protonations which lead to insertion. ", "Furthermore, possible intermediate states which disrupt membranes at pH 6.4 were proposed based on tryptophan fluorescence quenching and NMR data." ]

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[ "The PRISM spin war has begun\n\nThe war over how to spin revelations of the National Security Agency’s latest spying program has officially begun.", "\n\nOn the heels of media reports that the NSA has gained access to the servers of nine leading tech companies — enabling the spy agency to examine emails, video, photographs, and other digital communications — Google has issued a strongly worded statement denying that the company granted the government \"direct access\" to its servers. ", "That statement goes so far as to say that the company hasn’t even heard of \"a program called PRISM until yesterday.\"", "\n\nAt first glance, Google’s statement is difficult to believe. ", "Senior intelligence officials have confirmed the program’s existence, and Google’s logo is prominently listed on internal NSA documents describing participating companies. ", "But Google may be engaging in a far more subtle public relations strategy than outright denial.", "\n\nGoogle’s statement hinges on three key points: that it did not provide the government with \"direct access\" to its servers, that it did not set up a \"back door\" for the NSA, and that it provides \"user data to governments only in accordance with the law.\"", "\n\nAccording to Chris Soghoian, a tech expert and privacy researcher at the American Civil Liberties Union, the phrase \"direct access\" connotes a very specific form of access in the IT-world: unrestricted, unfettered access to information stored on Google servers. ", "In order to run a system such as PRISM, Soghoian explains, such access would not be required, and Google’s denial that it provided \"direct access\" does not necessarily imply that the company is denying having participated in the program. ", "Typically, the only people having \"direct access\" to the servers of a company like Google would be its engineers. (", "Facebook’s Mark Zuckerberg has issued a similarly worded denial in which he says his company has not granted the government \"direct access\" to its servers,\" but his language mirrors Google’s denial about direct access.)", "\n\nA similar logic applies to Google’s denial that it set up a \"back door.\" ", "According to Soghoian, the phrase \"back door\" is a term of art that describes a way to access a system that is neither known by the system’s owner nor documented. ", "By denying that it set up a back door, Google is not denying that it worked with the NSA to set up a system through which the agency could access the company’s data.", "\n\nAccording to Soghoian, the NSA could have gained access to tech company servers by working with the companies to set up something similar to an API — a tool these firms use to give developers limited access to company data. ", "Google has denied that an API was used, but that denial doesn’t exclude the possibility that a similar tool was used.", "\n\nTo protect itself against allegations that it inappropriately compromised user data, Google further notes in its statement that the company provides \"user data to governments only in accordance with the law.\" ", "Despite the outrage directed at the NSA and the Obama administration, PRISM — as currently described — is in all likelihood within the bounds of the law. ", "In the aftermath of the 2005 disclosure that the Bush administration had carried out a warrantless wiretapping program, Congress passed the FISA Amendments Act of 2008 and the Protect America Act of 2007. ", "But those laws did not outlaw the kinds of actions carried out by PRISM.", "\n\nAs for Google’s claim to have never heard of PRISM, would the intelligence officials who reportedly collaborated with Google have used the program’s actual codename?", "\n\nThe tech companies alleged to have participated in PRISM aren’t the only ones who appear to be spinning PRISM to their advantage.", "\n\nOn Friday, U.S. government sources told Reuters that PRISM was used to foil a 2009 plot to bomb the New York City subway. ", "In all likelihood, such counter-leaks will continue in the days ahead as intelligence officials try to portray the program as essential to national security.", "\n\nWelcome to the PRISM spin war." ]

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[ "Food\n\nThis is the best sunny side up egg (or Over-Easy egg) I’ve ever had\nthe pleasure of sampling just now. ", "Most of the fried eggs here (RM\n0.50) are over-fried but this one takes the cake. ", "The cook has mastered\nthe Zen of sunny side up eggs.", "\n\nIt also looks like something rather interesting (check out the aureole) in a vague sort of way…\n\nThis is a blatant filler post, if you haven’t noticed (pioneered by\nsixthseal.com back in 2002 ;)). ", "My apologies, I have a lot on my mind\nright now." ]

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[ "Independent Dealers\n\nFabian Macken\n\nAVP — Performance Management, vAuto\n\nFabian Macken serves as associate vice president of Performance Management for vAuto. ", "In this role, Fabian oversees vAuto’s Performance Management team and supports client retention and new-client launch processes. ", "Previously, Fabian served as vAuto’s senior director of risk and retention. ", "Fabian joined vAuto in 2009 as a Performance Manager, following more than 20 years of retail automotive experience that included general manager and general sales manager positions. ", "Throughout his career, Fabian has completed numerous automotive leadership, management and sales training programs." ]

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[ "Aleksandr Maltsev (synchronised swimmer)\n\nAleksandr Evgenyevich Maltsev () (born 22 June 1995) is a Russian synchronised swimmer, two-times World champion and four-times European champion. ", "He was recognized as the best male artistic swimmer in 2015 and 2017 by FINA. ", "He is a pioneer in Russian artistic swimming.", "\n\nCareer\nMaltsev was enrolled by his mother in a synchronized swimming group at a local sports school in St. Petersburg when he was 7. ", "At the time, they accepted everyone, boys and girls. ", "At age of 10, Maltsev was selected for the St. Petersburg municipal team and at 15, he was training with Russia's female synchronized swimmers for the first time. ", "Despite being the only male synchronized swimmer in the national team, Maltsev continued to pursue his career even with attempts to divert his attention to water polo and diving. ", "He continued to train his favorite sport even though many people did not understand or support his desires.", "\n\nIn 2014, FINA officially approved of adding mixed-gender events in synchronized swimming and diving under its banner after a vote at the Extraordinary Congress in Doha (Qatar). ", "Maltsev began pairing up with Darina Valitova. ", "They competed at the Italian Open Test in Mixed Duet free where they took gold medals.", "\n\nAt the 2015 World Aquatics Championships in Kazan, Maltsev/Valitova represented Russia at the inaugural Mixed Duet in synchronized swimming, after leading the preliminaries in Mixed Duet technical, they finished second in the finals losing just 0.2122 points to Americans Bill May and Christina Jones. ", "They avenged their loss by winning the gold in Mixed Duet free with a score of 91.7333 points ahead of May/Lum.", "\n\nMaltsev partnered with Mikhaela Kalancha at the 2016 European Championships; where they won gold in mixed free and technical routines. ", "In November 2016, pair Maltsev/Kalancha performed the newly-composed Swan Lake at the 11th FINA Synchronized Swimming World Trophy in Yangzhou (China) and won the title in 92.6000 points.", "\nThe next year, they took part in the 2017 World Aquatics Championships in Budapest, and won gold and silver in the mixed free and technical routines respectively.", "\n\nIn 2018, he began partnering with Mayya Gurbanberdieva. ", "Their duet took gold medals in free routine of two steps of the FINA Artistic Swimming World Series 2018 in Paris and Syros Island. ", "At the 2018 European Championships there they won gold in mixed free and technical routines.", "\n\nEducation\nHe graduated from the Russian State University of Physical Education, Sport, Youth and Tourism.", "\n\nAwards and titles\nHonored Master of Sports of Russia.", "\nThe best male artistic swimmer (2015, 2017) by FINA.", "\n\nReferences\n\nExternal links\n\n \nAleksandr Maltsev Sports bio\n\nCategory:Living people\nCategory:Russian synchronized swimmers\nCategory:1995 births\nCategory:Sportspeople from Saint Petersburg\nCategory:World Aquatics Championships medalists in synchronised swimming\nCategory:Synchronized swimmers at the 2015 World Aquatics Championships\nCategory:Synchronized swimmers at the 2017 World Aquatics Championships" ]

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[ "John Farnham & Tom Jones – Together in Concert\n\nJohn Farnham and Tom Jones – Together in Concert is an Australian tour featuring John Farnham and Tom Jones performing together for ten concerts throughout the capital cities of Perth, Sydney, Brisbane, and Melbourne. ", "Jones sings his major hits, before Farnham performs his set including hits \"One\", \"Pressure Down\", \"That's Freedom\", \"Heart's On Fire\", \"Playing To Win\", \"Every Time You Cry\", \"Man Of The Hour\", \"Age Of Reason\" and \"Burn For You\". ", "The pair then return to the stage together to perform four duets of soul classics: Sam and Dave's \"Hold On I'm Coming\", Otis Redding's \"Try A Little Tenderness\", Ray Charles' \"What'd I Say\", Arthur Conley's \"Sweet Soul Music\" and AC/DC's rock anthem, \"Long Way To The Top\".", "\n\nOn 31 May 2005, a CD album and DVD video were released from a show at the Rod Laver Arena at Melbourne Park. ", "The DVD release debuted at number 1 on the Australian charts, with the album reaching number 3, and being awarded as 3x platinum.", "\n\nTrack listing\n \"Mama Told Me Not to Come\" (Randy Newman) - 3:21\n \"200 Pounds of Heavenly Joy\" (Willie Dixon) - 3:04\n \"Man of the Hour\" (Sean Hosein, Dane DeViller, Steve Kipner) - 4:25\n \"What Am I Living For\" (Art Harris, Fred Jay) - 2:41\n \"It's Not Unusual\" (Gordon Mills, Les Reed) - 2:34\n \"Burn for You\" (Phil Buckle, John Farnham, Ross Fraser) - 4:22\n \"Playing to Win\" (Graeham Goble, John Farnham, David Hirschfelder, Stephen Housden, Spencer Proffer, Wayne Nelson, Steven Prestwich) - 3:06\n \"My Yiddishe Momme\" (Lew Pollack, Jack Yellen) - 2:29\n \"You're the Voice\" (Maggie Ryder, Chris Thompson, Andy Qunta, Keith Reid) - 4:39\n \"That Driving Beat\" (Willie Mitchell) - 3:04\n \"Hold On, I'm Coming\" (Isaac Hayes, David Porter) - 3:17\n \"Try a Little Tenderness\" (Harry M. Woods, James Campbell, Reginald Connelly) - 4:03\n \"What'd I Say\" (Ray Charles) - 4:42\n \"Sweet Soul Music\" (Sam Cooke, Otis Redding, Arthur Conley) - 3:26\n \"It's a Long Way to the Top (If You Wanna Rock 'n' Roll)\" (Malcolm Young, Angus Young, Bon Scott) - 5:34\n\nCharts\n\nWeekly charts\n\nYear-end charts\n\nCertifications\n\nReferences\n\nCategory:2005 live albums\nCategory:Tom Jones (singer) albums\nCategory:John Farnham live albums\nCategory:John Farnham video albums\nCategory:Collaborative albums\nCategory:Live video albums" ]

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[ "David Taylor:\nWith reference to reducing the paperwork burden on police officers, as a public institution and a public service, the police force, second only to this place, needs significantly higher levels of investment in information and communications technology to support its day-to-day work. ", "If my hon. ", "Friend speaks to police in his authority, particularly detective sergeants and police constables, they will tell him what proportion of their time they spend on such unproductive work.", "\n\nMr. Drew:\nMy hon. ", "Friend almost reads my mind, but not quite. ", "I accept his point, but the problem is not an internal police matter. ", "It involves the relationship with the Crown Prosecution Service, whether that relationship is conducted through computers or by human beings talking to one another. ", "I have some misgivings. ", "We have moved on from the impasse a few years ago involving who spoke to whom and how that was done. ", "It is a resource issue and also a matter of cultures. ", "Communication is improving, but it would help if there were computer systems that could talk to each other better. ", "That will be expensive and take time, because technology does not seem to do what we want it to do at the appropriate moment.", "\n\nI am assured that the situation is improving. ", "It would be nice to think about local solutions, but it merely exacerbates the problem if police forces get their own systems and the CPS does not do all that we want it to do. ", "There must be some centralisation, although I know that my chief constable and the Association of Chief Police Officers are a little worried about the apparent loss of independence. ", "They are worried about the pressures on them to deliver policing in their area.", "\n\nEffective centralisation is the only way forward. ", "We must recognise that policing at the level of divisions, not even at the level of a county force, is where decisions have to be taken and priorities outlined, so that people have confidence in their police and policing is carried out in the most appropriate way.", "\n\nI am happier this year. ", "In the negotiations that are taking place nationally, the Government's position is clear. ", "I wish that progress could be made more quickly, but I do not want any confrontation with the police. ", "They are my friends, and I go out with them regularly in my constituency, so I see the problems that they have. ", "We need to move on to make sure that the police are effective and deliver value for money, as we all want them to do.", "\n\n6.5 pm\n\nMr. Andrew Lansley (South Cambridgeshire):\nI am grateful for the opportunity to contribute to the debate.", "\n\nSeveral hon. ", "Members have spoken about the proportion of the overall increase of 6.1 per cent. ", "in the provision for policing that is being made available\n\n30 Jan 2002 : Column 332\n\nthrough total standard spending to enable police authorities to meet their responsibilities, and the proportion being allocated by the Home Office for its own purposes or governed by the Home Office for initiatives that must be delivered as priorities by police authorities. ", "I shall begin with that, and then touch on particular issues relating to Cambridgeshire, to which other hon. ", "Members have already referred.", "\n\nOf the overall 6.1 per cent.—£550 million—only about 40 per cent. ", "is being allocated to total standard spending. ", "So much of it is being allocated by central Government that the ability of police authorities to meet their responsibilities is being undermined. ", "The Home Office sets its priorities for police authorities. ", "Happily, after years of neglecting such matters, it is beginning to talk about important issues such as visible policing.", "\n\nFor police services such as my own in Cambridgeshire, visibility of policing is intensely difficult to achieve, given the relatively low numbers of police. ", "Cambridgeshire has the second lowest level of funding per head of population of any police authority in the country. ", "It is all very well setting an overall level of provision for policing, but if, as a consequence of Home Office priorities and control over spending, local police authorities cannot meet their responsibilities, there will be a deterioration in the visibility of policing, the prevention of crime and the ability to detect crime and follow it up.", "\n\nWe are beginning to see that in Cambridgeshire. ", "The number of incidents has gone up by 20 per cent. ", "in the past few years and is projected to increase at a faster rate. ", "The number of 999 calls is going up dramatically. ", "The ability of the police to respond to and follow up crime and to act proactively in local communities is being diminished.", "\n\nThe Home Office may assume that it makes provision for its own priorities, but that is not the case. ", "In Cambridgeshire, some of the demands have to be met from the police authority's budget, and go beyond what is provided centrally by the Home Office for its own priorities. ", "For example, £1 million is required from the local budget for the Airwaves project, £734,000 in the coming year for the implementation of the action for justice programme, £308,000 for the DNA programme, and £234,000 for the new national crime recording system. ", "The police authority must meet those needs from its budgets, and that diminishes the sum available for its own priorities.", "\n\nThe situation is even worse than that. ", "The police authority has to meet pay and pension pressures far in excess of what has been provided by the Home Office. ", "The Home Office has said that standard spending should rise by 2.6 per cent., ", "but grant has risen by only 2.3 per cent. ", "There is a national settlement of 3.5 per cent. ", "for police officers, and pension costs for the authority are rising at about 6 per cent. ", "After the pay, inflation and pension costs have been absorbed, there is no room for any response to other local pressures. ", "All the Home Office priorities, in addition to those that I mentioned, are biting deeply into the authority's ability to provide policing.", "\n\nWhat is the net result? ", "We have a modest increase in police numbers after a decline and years of trying to attain the same number of police as in 1997. ", "However, with a modest increase in the precept for the council tax precept, the prospect for next year is that we will not meet the gateway criteria for the crime fighting fund, and will\n\n30 Jan 2002 : Column 333\n\ntherefore lose the additional 24 police who should be available through it. ", "That is contrary to the views of the hon. ", "Member for Cambridge (Mrs. Campbell), who is no longer here to hear the facts. ", "If the police authority implemented a precept of 10 per cent., ", "it would lose the gateway criteria and the 24 additional police. ", "It would no longer be able to maintain its normal recruitment, and the net result would be a decline in the number of police in Cambridgeshire.", "\n\nTo fulfil the requirement for a 4 per cent. ", "increase in the budget, the police authority would have to increase its precept by 20 per cent. ", "to respond to the pressures and demands of policing in Cambridgeshire, and we are relatively underpoliced compared with the rest of the country and the police authority has to consult on a possible 30 per cent. ", "increase in the precept in the council tax. ", "Other increases are also being considered, including a possible 9.3 per cent. ", "by the county council, and the district council has to consider an increase of 40 per cent. ", "in its previously modest precept. ", "That adds up to substantial pressures on individuals through the council tax.", "\n\nThe Home Office is chasing a headline figure of 6.1 per cent. ", "and it has not accurately related it to the pressures that it places on police authorities. ", "It is indifferent to the fact that some police authorities will have to increase the council tax dramatically, and it did not attempt to cut its coat according to local cloth. ", "In future, it would be better for the Home Office to start by considering the policing that it wants to achieve locally and provide for greater devolution of budgets and discretion to enable local police authorities to fulfil their responsibilities.", "\n\nThe obvious candidate for such devolution is the crime fighting fund, and rural policing should also be taken into account in future formula allocations in order to provide properly for it. ", "We should also take proper account of the cost of living. ", "Other hon. ", "Members have talked about inadequate consideration of the cost of living and the provision of a service in places outside London, such as the Thames valley.", "\n\nIf I have an opportunity later, I may speak about the area cost adjustment in more detail. ", "However, people in the Thames valley should note that they will receive an 8 per cent. ", "uplift in their allocation through the area cost adjustment, which is not available to Cambridgeshire. ", "Yet housing costs and labour market pressures in Cambridge are at least as great as those in north Oxfordshire.", "\n\nEarlier, I asked about the net result. ", "An authority and a police service in Cambridgeshire, which have historically been poorly funded by Government, will receive an increase in grant of only 2.3 per cent. ", "this year. ", "Whatever other priorities may exist, the net result for my constituents will be a large increase in council tax simply to maintain existing levels of policing. ", "They want more police to deal with the greater incidence of crime, the greater number of 999 calls and the recent increases in recorded crime.", "\n\n6.13 pm\n\nDr. Ashok Kumar (Middlesbrough, South and Cleveland, East):\nI shall be brief. ", "I congratulate the Government on the settlement for the police force in my\n\n30 Jan 2002 : Column 334\n\narea of Cleveland, which received an increase of 4.47 per cent. ", "If we take into account the crime fighting fund, the rural fund and the capital increases, and compare the figures with those for last year, we have received an increase of 4.9 per cent.", "\n\nThe figures are much higher than those under the previous Government. ", "They appear to be increasing under our Government because of the great success of the dynamic economy that they have created. ", "We have thus been able to allocate more money to constituencies such as mine.", "\n\nThe rural part of my constituency—60 per cent. ", "of it is rural—will benefit most, because the targeted money will help greatly. ", "We have made good progress through the crime fighting fund: under it approximately 74 officers have been allocated for 2000–03. ", "We recruited 20 officers under that fund last year; we hope that we will be allocated 36 new officers by the end of this year; and we hope to have a further allocation of 18 officers for 2002–03.", "\n\nWe have also made progress on recruitment. ", "Police numbers have increased from 1,407 in March last year to 1,434. ", "The Government's spirit in tackling crime and ensuring that there are enough police officers to deal with it is a credit to the Labour party.", "\n\nMy right hon. ", "Friend made the allocation of 4.47 per cent., ", "which I and other Members of Parliament who represent the area appreciate, but there is a discrepancy. ", "I understand that the Government based their calculations on tax band D and reached a figure of 7p a week for the police precept. ", "The police authority tells me that the precept that it expects means approximately 50p a week. ", "Its method of calculating the required amount for fighting crime and that of the Government have led to two different figures. ", "I should be interested to know what my right hon. ", "Friend considers to be a sensible figure. ", "Ultimately, we must have the support of the communities that we represent and ensure that they are willing to back the increases in the police precept.", "\n\nI should also be interested to know whether my right hon. ", "Friend believes that the local authority should consult the people of Cleveland before it sets the police precept. ", "We are considering accountability and carrying the agreement of the people, so it is important to note that the four boroughs are not keen on the increases that the police authority has mentioned, and they therefore need a steer. ", "They told me that the police authority can impose whatever figure it wishes. ", "I do not know whether that is true and I await my right hon. ", "Friend's response.", "\n\nI am satisfied that the Government have made great strides in tackling crime and I look forward to hearing my right hon. ", "Friend's views." ]

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[ "What is the law regarding taking children across state lines after divorce? ", "Posted on May 13, 2011\n\nMy friend is from Kansas, she got married and moved just over the Missouri line. ", "She now want to file for divorce and move back here. ", "I was researching and found that you cant take children and move out of state until the divorce proceedings are final. ", "She doesn’t know anyone in Missouri and we live merely 40 minutes apart. ", "Just happens to be different states. ", "Is there some way to go about this without breaking any laws? ", "Her husband just recently became an American citizen and she is afraid that if he gets the chance he will take them to Mexico where he still has a large family.", "\n\nAsk a Local Attorney\n\nDisclaimer: The information found on this website is intended to be general legal information; it is not legal advice. ", "Specific legal advice can only be given with full knowledge of all of the facts and circumstances of your situation. ", "You should seek consultation with an attorney familiar with the laws of your state. ", "Posting a question on this website does not create an attorney-client relationship. ", "All questions you post will be available to the public; do not include confidential information in your question." ]

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[ "#include \"global.h\"\n#include \"battle_anim.h\"\n#include \"rom_8077ABC.h\"\n#include \"sprite.h\"\n#include \"task.h\"\n#include \"trig.h\"\n\nextern s16 gBattleAnimArgs[8];\nextern u8 gBattleAnimAttacker;\nextern u8 gBattleAnimTarget;\nextern const union AffineAnimCmd *const gSpriteAffineAnimTable_83D752C[];\n\nvoid sub_80D3554(struct Sprite *sprite);\nvoid sub_80D3698(struct Sprite *sprite);\nvoid sub_80D3728(struct Sprite *sprite);\nstatic void sub_80D35DC(struct Sprite *);\nstatic void sub_80D365C(u8);\nstatic void sub_80D370C(struct Sprite *);\n\n// energy_wave (animates steady \"waves\" of energy)\n// Used in Hydro Pump, Mud Shot, Signal Beam, Flamethrower, Psywave, and\n// Hydro Cannon.", "\n\nconst union AnimCmd gSpriteAnim_83D91DC[] =\n{\n ANIMCMD_FRAME(0, 1),\n ANIMCMD_FRAME(4, 1),\n ANIMCMD_FRAME(8, 1),\n ANIMCMD_FRAME(12, 1),\n ANIMCMD_JUMP(0),\n};\n\nconst union AnimCmd *const gSpriteAnimTable_83D91F0[] =\n{\n gSpriteAnim_83D91DC,\n};\n\nconst struct SpriteTemplate gBattleAnimSpriteTemplate_83D91F4 =\n{\n .tileTag = ANIM_TAG_WATER_ORB,\n .paletteTag = ANIM_TAG_WATER_ORB,\n .oam = &gOamData_837E04C,\n .anims = gSpriteAnimTable_83D91F0,\n .images = NULL,\n .affineAnims = gDummySpriteAffineAnimTable,\n .callback = sub_80D3554,\n};\n\nconst struct SpriteTemplate gBattleAnimSpriteTemplate_83D920C =\n{\n .tileTag = ANIM_TAG_BROWN_ORB,\n .paletteTag = ANIM_TAG_BROWN_ORB,\n .oam = &gOamData_837E04C,\n .anims = gSpriteAnimTable_83D91F0,\n .images = NULL,\n .affineAnims = gDummySpriteAffineAnimTable,\n .callback = sub_80D3554,\n};\n\nconst struct SpriteTemplate gBattleAnimSpriteTemplate_83D9224 =\n{\n .tileTag = ANIM_TAG_GLOWY_RED_ORB,\n .paletteTag = ANIM_TAG_GLOWY_RED_ORB,\n .oam = &gOamData_837DF24,\n .anims = gDummySpriteAnimTable,\n .images = NULL,\n .affineAnims = gDummySpriteAffineAnimTable,\n .callback = sub_80D3554,\n};\n\nconst struct SpriteTemplate gBattleAnimSpriteTemplate_83D923C =\n{\n .tileTag = ANIM_TAG_GLOWY_GREEN_ORB,\n .paletteTag = ANIM_TAG_GLOWY_GREEN_ORB,\n .oam = &gOamData_837DF24,\n .anims = gDummySpriteAnimTable,\n .images = NULL,\n .affineAnims = gDummySpriteAffineAnimTable,\n .callback = sub_80D3554,\n};\n\nconst union AnimCmd gSpriteAnim_83D9254[] =\n{\n ANIMCMD_FRAME(16, 2),\n ANIMCMD_FRAME(32, 2),\n ANIMCMD_FRAME(48, 2),\n ANIMCMD_JUMP(0),\n};\n\nconst union AnimCmd *const gSpriteAnimTable_83D9264[] =\n{\n gSpriteAnim_83D9254,\n};\n\nconst struct SpriteTemplate gBattleAnimSpriteTemplate_83D9268 =\n{\n .tileTag = ANIM_TAG_SMALL_EMBER,\n .paletteTag = ANIM_TAG_SMALL_EMBER,\n .oam = &gOamData_837DF34,\n .anims = gSpriteAnimTable_83D9264,\n .images = NULL,\n .affineAnims = gDummySpriteAffineAnimTable,\n .callback = sub_80D3554,\n};\n\nconst struct SpriteTemplate gBattleAnimSpriteTemplate_83D9280 =\n{\n .tileTag = ANIM_TAG_BLUE_RING,\n .paletteTag = ANIM_TAG_BLUE_RING,\n .oam = &gOamData_837E034,\n .anims = gDummySpriteAnimTable,\n .images = NULL,\n .affineAnims = gSpriteAffineAnimTable_83D752C,\n .callback = sub_80D3554,\n};\n\nconst union AffineAnimCmd gSpriteAffineAnim_83D9298[] =\n{\n AFFINEANIMCMD_FRAME(0x3, 0x3, 10, 50),\n AFFINEANIMCMD_FRAME(0x0, 0x0, 0, 10),\n AFFINEANIMCMD_FRAME(0xFFEC, 0xFFEC, -10, 20),\n AFFINEANIMCMD_END,\n};\n\nconst union AffineAnimCmd gSpriteAffineAnim_83D92B8[] =\n{\n AFFINEANIMCMD_FRAME(0x150, 0x150, 0, 0),\n AFFINEANIMCMD_END,\n};\n\nconst union AffineAnimCmd *const gSpriteAffineAnimTable_83D92C8[] =\n{\n gSpriteAffineAnim_83D9298,\n};\n\nconst union AffineAnimCmd *const gSpriteAffineAnimTable_83D92CC[] =\n{\n gSpriteAffineAnim_83D92B8,\n};\n\nconst struct SpriteTemplate gBattleAnimSpriteTemplate_83D92D0 =\n{\n .tileTag = ANIM_TAG_WATER_ORB,\n .paletteTag = ANIM_TAG_WATER_ORB,\n .oam = &gOamData_837E10C,\n .anims = gSpriteAnimTable_83D91F0,\n .images = NULL,\n .affineAnims = gSpriteAffineAnimTable_83D92C8,\n .callback = sub_80D3698,\n};\n\nconst struct SpriteTemplate gBattleAnimSpriteTemplate_83D92E8 =\n{\n .tileTag = ANIM_TAG_WATER_ORB,\n .paletteTag = ANIM_TAG_WATER_ORB,\n .oam = &gOamData_837E10C,\n .anims = gSpriteAnimTable_83D91F0,\n .images = NULL,\n .affineAnims = gSpriteAffineAnimTable_83D92CC,\n .callback = sub_80D3728,\n};\n\nvoid sub_80D3554(struct Sprite *sprite)\n{\n InitAnimSpritePos(sprite, 1);\n\n sprite->data[0] = 30;\n sprite->data[1] = sprite->pos1.x;\n sprite->data[2] = GetBattlerSpriteCoord(gBattleAnimTarget, 2);\n sprite->data[3] = sprite->pos1.y;\n sprite->data[4] = GetBattlerSpriteCoord(gBattleAnimTarget, 3);\n\n InitAnimLinearTranslation(sprite);\n\n sprite->data[5] = 0xD200 / sprite->data[0];\n sprite->data[7] = gBattleAnimArgs[3];\n\n if (gBattleAnimArgs[7] > 127)\n {\n sprite->data[6] = (gBattleAnimArgs[7] - 127) << 8;\n sprite->data[7] = -sprite->data[7];\n }\n else\n {\n sprite->data[6] = gBattleAnimArgs[7] << 8;\n }\n\n sprite->callback = sub_80D35DC;\n sprite->callback(sprite);\n}\n\nstatic void sub_80D35DC(struct Sprite *sprite)\n{\n if (TranslateAnimLinear(sprite))\n {\n DestroyAnimSprite(sprite);\n }\n\n sprite->pos2.y += Sin(sprite->data[6] >> 8, sprite->data[7]);\n if (((sprite->data[6] + sprite->data[5]) >> 8) > 127)\n {\n sprite->data[6] = 0;\n sprite->data[7] = -sprite->data[7];\n }\n else\n {\n sprite->data[6] += sprite->data[5];\n }\n}\n\nvoid sub_80D3630(u8 taskId)\n{\n gTasks[taskId].data[0] = gBattleAnimArgs[0];\n gBattleAnimArgs[7] = 0;\n gTasks[taskId].func = sub_80D365C;\n}\n\nstatic void sub_80D365C(u8 taskId)\n{\n gBattleAnimArgs[7] = (gBattleAnimArgs[7] + 3) & 0xFF;\n if (--gTasks[taskId].data[0] == 0)\n {\n DestroyAnimVisualTask(taskId);\n }\n}\n\nvoid sub_80D3698(struct Sprite *sprite)\n{\n u8 subpriority;\n\n sprite->pos1.x = GetBattlerSpriteCoord(gBattleAnimAttacker, 0);\n sprite->pos1.y = GetBattlerSpriteCoord(gBattleAnimAttacker, 1);\n sprite->pos2.y = -10;\n\n subpriority = GetBattlerSubpriority(gBattleAnimAttacker);\n\n if (!", "IsContest())\n {\n if (GetBattlerSide(gBattleAnimAttacker) == 0)\n {\n sprite->pos2.x = 10;\n sprite->subpriority = subpriority + 2;\n }\n else\n {\n sprite->pos2.x = -10;\n sprite->subpriority = subpriority - 2;\n }\n }\n else\n {\n sprite->pos2.x = -10;\n sprite->subpriority = subpriority + 2;\n }\n\n sprite->callback = sub_80D370C;\n}\n\nstatic void sub_80D370C(struct Sprite *sprite)\n{\n if (sprite->affineAnimEnded)\n {\n DestroyAnimSprite(sprite);\n }\n}\n\nvoid sub_80D3728(struct Sprite *sprite)\n{\n int var1, var2;\n\n if (GetBattlerSide(gBattleAnimAttacker) == GetBattlerSide(gBattleAnimTarget))\n {\n gBattleAnimArgs[0] *= -1;\n\n if (GetBattlerPosition(gBattleAnimAttacker) == 0 || GetBattlerPosition(gBattleAnimAttacker) == 1)\n {\n gBattleAnimArgs[0] *= -1;\n }\n\n }\n\n if ((gBattleAnimArgs[5] & 0xFF00) == 0)\n var1 = 1;\n else\n var1 = 0;\n\n if ((u8)gBattleAnimArgs[5] == 0)\n var2 = 3;\n else\n var2 = 1;\n\n InitAnimSpritePos(sprite, var1);\n\n if (GetBattlerSide(gBattleAnimAttacker) !", "= 0)\n {\n gBattleAnimArgs[2] = -gBattleAnimArgs[2];\n }\n\n sprite->data[0] = gBattleAnimArgs[4];\n sprite->data[2] = GetBattlerSpriteCoord(gBattleAnimTarget, 2) + gBattleAnimArgs[2];\n sprite->data[4] = GetBattlerSpriteCoord(gBattleAnimTarget, var2) + gBattleAnimArgs[3];\n sprite->callback = StartAnimLinearTranslation;\n StoreSpriteCallbackInData(sprite, DestroyAnimSprite);\n}\n" ]

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[ "News and information\n\nSony’s Shutdown-Purchase Of OnLive Could Advance The Future Of PlayStation\n\nSony's purchase of OnLive means an end for OnLive's streaming services, but the influx of patents could help develop future Sony cloud gaming ventures.", "\n\nThe streaming game service OnLive has been acquired by Sony, who will be shutting down the service as of April 30th while the company repurposes OnLive’s patents and technology for Sony gaming services.", "\n\nAfter the purchase, Gaikai’s technology was integrated into both the PlayStation 4 and PlayStation Vita, as well as the upcoming PlayStation Now streaming service.", "\n\nThis latest sale nets Sony all of OnLive’s 140 cloud gaming patents. ", "Philip Rosenberg, Sony Computer Entertainment America’s Senior Vice President for Global Business Development and Publisher Relations, said in a recent statement that the purchase, “gives Sony a formidable patent portfolio in cloud gaming,” that will open up new possibilities for the PlayStation crowd.", "\n\nAlthough initially hailed as a wildly exciting mover in the gaming world and a very literal game-changer, OnLive has seen its share of ups and downs. ", "In 2012 it saw a disastrous low point and universal layoffs brought about by interpersonal issues and a failure to achieve profitability, only to relaunch in the spring of 2014 with its Steam-streaming service Cloudlift.", "\n\nOnLive’s tone was sorrowful and apologetic as they announced Sony’s decision. “", "It is with great sadness that we must bring the OnLive Game Service to a close. ", "Sony is acquiring important parts of OnLive, and their plans don’t include a continuation of the game service in its current form,” after April 30th, although they noted that subscribers would not be charged for the remainder of their subscriptions.", "\n\nOnLive closed their statement with gratefulness to their subscriber base, saying, “We thank you from the bottom of our hearts for being an OnLive customer, and we wish you all the best.”", "\n\nOnLive’s native OnLive Game System and OnLive Universal Wireless Controller do not work with any other game systems, but new subscribers who purchased either on or after February 1st, 2015 will be able to contact the company for a refund. ", "Details can be found on their support site." ]

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[ "using System;\nusing System.", "ComponentModel;\n\nnamespace GitHub.", "DistributedTask.", "Pipelines.", "ObjectTemplating\n{\n [EditorBrowsable(EditorBrowsableState.", "Never)]\n public sealed class PipelineTemplateConstants\n {\n public const String Always = \"always\";\n public const String BooleanStepsContext = \"boolean-steps-context\";\n public const String BooleanStrategyContext = \"boolean-strategy-context\";\n public const String CancelTimeoutMinutes = \"cancel-timeout-minutes\";\n public const String Cancelled = \"cancelled\";\n public const String Clean= \"clean\";\n public const String Container = \"container\";\n public const String ContinueOnError = \"continue-on-error\";\n public const String Credentials = \"credentials\";\n public const String Defaults = \"defaults\";\n public const String Env = \"env\";\n public const String Event = \"event\";\n public const String EventPattern = \"github.event\";\n public const String Exclude = \"exclude\";\n public const String FailFast = \"fail-fast\";\n public const String Failure = \"failure\";\n public const String FetchDepth = \"fetch-depth\";\n public const String GitHub = \"github\";\n public const String HashFiles = \"hashFiles\";\n public const String Id = \"id\";\n public const String If = \"if\";\n public const String Image = \"image\";\n public const String Include = \"include\";\n public const String Inputs = \"inputs\";\n public const String Job = \"job\";\n public const String JobDefaultsRun = \"job-defaults-run\";\n public const String JobIfResult = \"job-if-result\";\n public const String JobOutputs = \"job-outputs\";\n public const String Jobs = \"jobs\";\n public const String Lfs = \"lfs\";\n public const String Matrix = \"matrix\";\n public const String MaxParallel = \"max-parallel\";\n public const String Name = \"name\";\n public const String Needs = \"needs\";\n public const String NumberStepsContext = \"number-steps-context\";\n public const String NumberStrategyContext = \"number-strategy-context\";\n public const String On = \"on\";\n public const String Options = \"options\";\n public const String Outputs = \"outputs\";\n public const String OutputsPattern = \"needs.*.outputs\";\n public const String Password = \"password\";\n public const String Path = \"path\";\n public const String Pool = \"pool\";\n public const String Ports = \"ports\";\n public const String Result = \"result\";\n public const String Run = \"run\";\n public const String RunDisplayPrefix = \"Run \";\n public const String Runner = \"runner\";\n public const String RunsOn = \"runs-on\";\n public const String Secrets = \"secrets\";\n public const String Services = \"services\";\n public const String Shell = \"shell\";\n public const String Skipped = \"skipped\";\n public const String StepEnv = \"step-env\";\n public const String StepIfResult = \"step-if-result\";\n public const String StepWith = \"step-with\";\n public const String Steps = \"steps\";\n public const String Strategy = \"strategy\";\n public const String StringStepsContext = \"string-steps-context\";\n public const String StringStrategyContext = \"string-strategy-context\";\n public const String Submodules = \"submodules\";\n public const String Success = \"success\";\n public const String Template = \"template\";\n public const String TimeoutMinutes = \"timeout-minutes\";\n public const String Username = \"username\";\n public const String Uses = \"uses\";\n public const String VmImage = \"vmImage\";\n public const String Volumes = \"volumes\";\n public const String With = \"with\";\n public const String Workflow = \"workflow\";\n public const String Workflow_1_0 = \"workflow-v1.0\";\n public const String WorkflowRoot = \"workflow-root\";\n public const String WorkingDirectory = \"working-directory\";\n public const String Workspace = \"workspace\";\n }\n}\n" ]

{ "pile_set_name": "Github" }

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[ "Configuring Authentication for POP3 and IMAP4\n\nThis topic describes how to use the Exchange Management Console and the Exchange Management Shell to configure authentication options on the Microsoft Exchange Server 2007 computer that has the Post Office Protocol version 3 (POP3) and Internet Message Access Protocol version 4rev1 (IMAP4) services enabled.", "\n\nBefore you configure the authentication options to use with POP3 and IMAP4, make sure that you understand the process for configuring Secure Sockets Layer (SSL) for the server that is running Microsoft Exchange that has the Client Access server role installed. ", "For more information about how to help secure communications, read the following topics:\n\nTo perform the following procedures on a computer that has the POP3 service enabled, the account you use must be delegated the Exchange Server Administrators role and membership in the local Administrators group on the target server.", "\n\nFor more information about permissions, delegating roles, and the rights that are required to administer Exchange 2007, see Permission Considerations.", "\n\nThere are three authentication options that you can use with POP3 and IMAP4. ", "These options are configured when you use the Exchange Management Console or the Set-PopSettings and Set ImapSettings cmdlets in the Exchange Management Shell. ", "Additionally, there are default ports that are used, depending on the authentication setting that you are using.", "\n\nThe following table describes the default ports that are used with different authentication settings.", "\n\nAuthentication options for POP3 and IMAP4\n\nAuthentication Method\n\nValue\n\nDefault Port\n\nDescription\n\nPlainTextLogin\n\n1\n\n110 (POP3)\n\n995 (POP3 SSL)\n\n143 (IMAP4)\n\n993 (IMAP4 SSL)\n\nTLS encryption is not required on port 110.", "\n\nUser name and password are sent not encrypted unless the underlying connection is encrypted by using TLS or SSL.", "\n\nFor IMAP4, this corresponds to using the \"login\" command to authenticate to the Exchange 2007 computer that has the Mailbox server role installed.", "\n\nPlainTextAuthentication\n\n2\n\n110 (POP3)\n\n995 (POP3 SSL)\n\n143 (IMAP4)\n\n993 (IMAP4 SSL)\n\nTLS encryption is not required on port 110 and port 143. ", "However, Basic authentication is permitted only on a port that uses TLS or SSL encryption.", "\n\nFor IMAP4, this corresponds to using the \"authenticate\" command to authenticate to the Mailbox server.", "\n\nSecureLogin\n\n3\n\n110 (POP3)\n\n995 (POP3 SSL)\n\n143 (IMAP4)\n\n993 (IMAP4 SSL)\n\nConnection on port 110 and port 143 must use TLS encryption before authenticating.", "\n\nYou can use the Exchange Management Console or the Exchange Management Shell to configure the ports that you want to use, depending on the authentication setting that you are using for POP3 and IMAP4 on an Exchange 2007 server. ", "You can also specify connection time-out limits for users.", "\n\nFor more information about how to use the Exchange Management Shell and the Exchange Management Console to configure authentication options for POP3 and IMAP4, see the following topics:" ]

{ "pile_set_name": "Pile-CC" }

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[ "Introduction {#s1}\n============\n\nRheumatoid arthritis (RA) is a chronic, progressive, autoimmune, inflammatory disorder that affects approximately 1% of the population in the United States (Lee and Weinblatt, [@B28]). ", "Among RA patients, the severity of disease, the spectrum of clinical involvement and the response to therapy vary widely, resulting in significant diagnostic and management challenges. ", "RA is currently monitored via repeated clinical assessment of specific signs and symptoms, and by a variety of blood and radiological tests. ", "Unfortunately, none of the clinical laboratory tests in use today can reliably assess disease activity or predict flares of disease or the extent of underlying joint damage.", "\n\nRA is characterized by chronic inflammation and hypertrophy of the synovial membranes. ", "Inflammation of the joint occurs in response to production of growth factors, cytokines, and chemokines by many different cell types present in synovium and cartilage, in addition to infiltrating cells from the peripheral blood. ", "Cartilage and bone destruction subsequently occur through the enhanced actions of prostaglandins, leukotrienes, and the matrix degrading metalloproteinases (MMPs). ", "The importance of interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) in animal models of RA is well documented (Saklatvala, [@B45]; Issekutz et al., [", "@B22]; Hata et al., [", "@B17]). ", "TNF-α is known to stimulate IL-1 and interleukin-6 (IL-6) production in synovial tissue (Pettipher et al., [", "@B43]; Brahn et al., [", "@B9]). ", "These cytokines enhance migration of inflammatory cells into the joint and stimulate MMP production in synovial fibroblasts and chondrocytes (Pettipher et al., [", "@B43]).", "\n\nAlthough the most important actions of these proteins are likely to occur in the joint, the joint space is relatively inaccessible, prohibiting quantitative measurement of cytokines. ", "Recent advances in the clinical application of pharmacogenomics suggest that biomarkers of disease activity and drug efficacy can be identified in blood to enable the identification of specific patient populations and to monitor subclinical changes in disease status and responses to treatment over time (Frank and Hargreaves, [@B15]; McLoughlin et al., [", "@B33]; Luo et al., [", "@B30]). ", "Changes in the serum levels of several proteins have been observed in RA patients: cytokines such as IL-1α, IL1-β, IL-6, IL-10, and TNF-α are increased in RA compared to normal (Deane et al., [", "@B11]; Milman et al., [", "@B36]); and intercellular adhesion molecule-1 (ICAM-1) level is increased in juvenile RA compared to normal (Bloom et al., [", "@B7]; Ishikawa et al., [", "@B21]). ", "Factors such as protein instability and sampling variability may, however, limit analyses of serum protein expression. ", "Because altered gene expression precedes release of cytokines and other immunologically important signaling elements, analysis of specific messenger RNA (mRNA) species associated with these changes will provide the earliest diagnostic signs of disease progression and/or flare. ", "Blood samples from patients with RA have been studied by microarray to profile complex expression patterns of genes contributing to inflammatory joint disease (Bovin et al., [", "@B8]; Olsen et al., [", "@B38]; Batliwalla et al., [", "@B6]; Edwards et al., [", "@B13]; van der Pouw Kraan et al., [", "@B49]; Ishikawa et al., [", "@B21]; Teixeira et al., [", "@B47]; Deane et al., [", "@B11]).", "\n\nWe have previously shown that among healthy volunteers, expression of a number of inflammatory genes can be accurately measured by quantitative reverse transcriptase PCR (qRT-PCR) from peripheral blood samples collected over time, and that this expression is relatively stable (McLoughlin et al., [", "@B33]). ", "Importantly, these data suggest that normal reference ranges can be established for the expression of a broad set of inflammatory genes in human whole blood. ", "Here, we use qRT-PCR to measure inflammatory gene expression in whole blood obtained at a single time point from RA patients with either active (\"unstable\") or stable disease on DMARD therapy, and patients with stable disease on combination therapy with a DMARD and anti-TNF-α agent (\"combination\"), and compared the changes in inflammatory gene expression in these groups to levels in whole blood obtained from healthy controls.", "\n\nMaterials and methods {#s2}\n=====================\n\nSubject characteristics\n-----------------------\n\nSamples from blood donor subjects were collected for the current study with approval of the University of Colorado Institutional Review Board and after obtaining written consent from each volunteer. ", "Whole blood samples were collected at a single time point from 122 apparently healthy blood donors at a local blood bank (Bonfils Blood Center, Denver, CO). ", "Enrollment criteria for blood donors followed the American Red Cross donor standards. ", "Subject age was normally distributed and ranged from 22 to 82 years, with an average age of 47.2 ± 13.1 years. ", "Females (*N* = 63) and males (*N* = 59) were represented in about equal numbers, and 82% of the subjects were Caucasian. ", "RA patients eligible for the study met the following inclusion criteria: (1) diagnosis of RA according to the American College of Rheumatology 1987 diagnostic criteria (Arnett et al., [", "@B3]); (2) 18 years of age or older; (3) subjects with \"stable\" RA as defined by presence or history of moderate to severe RA on stable doses for the previous 3 months of DMARDs, NSAIDs, or oral corticosteroids (≤10 mg/day of prednisolone or equivalent); and (4) subjects with \"unstable\" active RA as defined by 6 or more swollen joints or 9 or more painful or tender joints at baseline and C-reactive protein (CRP) ≥2 mg/dL at the initial visit and who required more aggressive therapy. ", "Exclusion criteria included: (1) any previous treatment with a non-DMARD immunosuppressive drug; (2) use of any investigational drug or biological agent (except anti-TNF-α therapies) within 3 months prior to enrollment; (3) previous diagnosis of any acute or chronic infectious disease, or with current signs or symptoms of severe, progressive, or uncontrolled systemic disease; (4) pregnancy; (5) history of malignancy in the 5 years prior to study enrollment; or (6) ACR functional class IV. ", "In addition to collection of whole blood samples, physical examination, physician assessment of disease activity and morning stiffness, patient assessment of disease and pain activity, and joint assessment (based on a 66/68-joint count excluding distal interphalangeal joints) were performed at baseline and at 12 weeks after initiation of anti-TNF-α therapy (or continuation of previous DMARD therapy in stable RA patients).", "\n\nUsing the criteria described above, there were three experimental patient subpopulation groups: (1) RA patients who were on a systemic disease-modifying anti-rheumatoid drug (DMARD, either oral prednisone or oral methotrexate), with active disease and judged by their physician to require a change in therapy (\"unstable\") (*N* = 18); (2) RA patients receiving DMARD therapy for more than 3 months and judged by their physicians *not* to require a change in therapy (\"stable\") (*N* = 26); and (3) clinically stable RA subjects treated for more than 3 months with a DMARD *plus* one of two different anti-TNF-α therapies (infliximab or etanercept) and judged by their physician *not* to require a change in therapy (\"combination\") (*N* = 20). ", "Characteristics of each experimental patient group are shown in Table [1](#T1){ref-type=\"table\"}.", "\n\n###### \n\n**Clinical features of RA patient subpopulation groups tested for qRT-PCR analysis**.", "\n\n **Clinical feature** **Unstable on DMARD (*n* = 18)** **Stable on DMARD (*n* = 26)** **Stable on combination therapy (*n* = 20)**\n ------------------------------ ---------------------------------- -------------------------------- ----------------------------------------------\n Gender (% female) 79 61 85\n Age (years) 54.1 55.8 57.7\n Race (% white, non-Hispanic) 67 50 90\n Duration of disease (months) 220 200 227\n DMARD use (%) 75 100 100\n Prednisone use (%) 64 75 25\n MTX weekly dose (mg) 15.5 9.95 14.5\n\nSee \"Materials and Methods\" section for details on patient background and selection.", "\n\nPreparation of nucleic acids and quantitative PCR analysis\n----------------------------------------------------------\n\nBlood was collected from study subjects by standard phlebotomy methods into PAXgene™ tubes (PreAnalytiX, Valencia, CA) to stabilize mRNA levels. ", "Samples were frozen at −70°C and shipped on dry ice in compliance with International Air Transport Association (IATA) shipping regulations. ", "Total RNA was extracted as described previously using the PAXgene™ Blood RNA System (Rainen et al., [", "@B44]). ", "The purity and integrity of each RNA sample was determined and the mRNA was converted to cDNA by reverse transcription (Rainen et al., [", "@B44]). ", "First-strand cDNA was synthesized from random hexamer-primed RNA templates on the ABI Prism™ 6700 Nucleic Acid Automated Workstation using TaqMan® Reverse Transcription Reagents (Applied Biosystems, Multiscribe \\#4311235, Foster City, CA), according to the manufacturer\\'s procedure.", "\n\nTarget gene products were analyzed by quantitative PCR of each cDNA preparation using 2X TaqMan® Universal PCR Master Mix (Applied Biosystems, \\#4305719, Foster City, CA) and Source Precision Medicine\\'s proprietary primer/probe sets and adhering to previously described protocols (McLoughlin et al., [", "@B33]). ", "Forty-eight inflammation- and immune-related gene products that were originally selected and verified (McLoughlin et al., [", "@B33]) were analyzed with slight modification (Table [2](#T2){ref-type=\"table\"}). ", "For example, apoptotic protease activating factor 1 (APAF1) and Cytochrome B-245 beta polypeptide (CYBB) were replaced with transforming growth factor beta 1 (TGFB1, a pro- and anti-inflammatory cytokine) and vascular endothelial growth factor (VEGF, an inducer of angiogenesis) because of their involvement in inflammation and the pathogenesis of RA (Kasama et al., [", "@B24]; Mattey et al., [", "@B32]). ", "Reactions were run in four replicates on an ABI Prism 7700 Sequence Detection System. ", "The amount of cDNA added to each reaction was held to a narrow range, within 1.5 C~T~\\'s, based on the threshold cycle (C~T~) of the 18S RNA control reaction. ", "The coefficient of variation in the C~T~ values detected for each gene loci were less than 2% in a study that consisted of more than 1000 repeat analyses of the same freezer-stored sample. ", "The repeat analyses were performed over greater than a 2-year period.", "\n\n###### \n\n**List of 48 inflammatory genes analyzed in the study and mean ΔCT of gene expression in healthy subjects**.", "\n\n **HUGO designation** **Gene name** **Gene function** **Mean ΔCT of healthy subjects (*n* = 122)**\n ---------------------- -------------------------------------------------------- ------------------------------------------------------------------------------------------------- ----------------------------------------------\n B7 CD80 Regulatory protein that may be associated with lupus 21.17\n C1QA Complement component 1, q subcomponent, A chain Serum complement system component, forms C1 complex with pro-enzymes C1r and C1s 21.64\n CD3Z CD247 molecule T-cell surface glycoprotein 15.20\n CD4 CD4 molecule Helper T-cell marker; accessory protein in the MHC/T-cell receptor interaction 15.84\n CD8A CD8a molecule Cytotoxic/suppressor T-cell marker; binds MHC I; thought to play role T-cell mediated killing 16.40\n CD14 CD14 molecule Monocyte LPS receptor; cooperates with MD-2 and TLR-4 in response to LPS 14.84\n CD19 CD19 molecule B-cell growth factor; membrane protein that potentiates receptor-dependent activation 18.65\n CXCL1 Chemokine (C-X-C motif) ligand 1 Chemotactic for neutrophils; pro-inflammatory; modulates metalloproteinase activity 19.78\n CXCL2 Chemokine (C-X-C motif) ligand 2 Chemotactic for neutrophils and hematopoietic precursor cells 23.32\n CSF2 Colony stimulating factor 2 *aka* GM-CSF; stimulates growth and differentiation of hematopoietic precursor cells 23.59\n CSF3 Colony stimulating factor 3 *aka* GCSF; cytokine that stimulates granulocyte development 23.45\n F3 Coagulation factor 3 (thromboplastin, tissue factor) *aka* thromboplastin, coagulation factor 3; responsible for coagulation catalysis 23.63\n HLA-DRB1 Major histocompatibility complex, class II, DR beta 1 Binds antigen for presentation to CD4^+^ cells 22.09\n HMOX1 Heme oxygenase (decycling) 1 Essential for heme catabolism; cleaves heme to form biliverdin and CO; endotoxin inducible 17.10\n HSPA1A Heat shock protein A1A Molecular chaperone; stabilizes AU rich mRNA; hydrophobic peptide 14.76\n ICAM1 Intercellular adhesion molecule 1 Endothelial cell surface molecule; regulates cell adhesion and trafficking of leukocytes 18.05\n IFNA2 Interferon, alpha 2 Interferon produced by macrophages with antiviral effects 22.20\n IFNG Interferon gamma Pro- and anti-inflammatory activity, TH~1~ cytokine, inflammatory mediator of activated T-cells 22.98\n IL1A Interleukin-1, alpha Pro-inflammatory; generally cytosolic, released during severe inflammatory disease 23.14\n IL1B Interleukin-1, beta Pro-inflammatory; made by activated macrophages; endogenous pyrogen 16.19\n IL1RN Interleukin-1 receptor antagonist Anti-inflammatory; inhibits binding of IL-1 its receptor without stimulating IL-1 activity 16.41\n IL2 Interleukin-2 T-cell growth factor, expressed by activated T-cells, TH~1~ cytokine 23.11\n IL4 Interleukin-4 Anti-inflammatory; TH~2~; suppresses cytokines, increases IL-1RN expression 23.25\n IL5 Interleukin-5 Stimulates eosinophil expansion and B-cell differentiation 22.70\n IL6 Interleukin-6 Pro- and anti-inflammatory activity; TH~2~ cytokine; regulates hematopoiesis 23.11\n IL8 Interleukin-8 Pro-inflammatory CXC chemokine; major secondary inflammatory mediator 21.04\n IL10 Interleukin-10 Anti-inflammatory; TH~2~ cytokine; suppresses production of pro-inflammatory cytokines 22.84\n IL12B Interleukin-12b Pro-inflammatory, TH~1~ cytokine, requires co-stimulation with IL-18 to induce IFN-γ 23.28\n IL13 Interleukin-13 Inhibits inflammatory cytokine production 23.09\n IL15 Interleukin-15 Pro-inflammatory; T-cell activator; inhibits apoptosis; with IL-2 induces IFN-γ and TNF-α 22.05\n IL18 Interleukin-18 Pro-inflammatory; TH~1~ cytokine; promotes apoptosis; induces IFNγ ; blocked by IL18BP 20.12\n IL18BP Interleukin-18 binding protein Binds and inactivates IL18; implicated in inhibition of early TH~1~ cytokine responses 17.59\n MMP3 Matrix metallopeptidase 3 *aka* stromelysin; degrades fibronectin, laminin, and gelatin 23.71\n MMP9 Matrix metallopeptidase 9 Degrades extracellular matrix molecules; made by neutrophils; Role in arthritis and metastasis 16.39\n PLA2G7 Phospholipase A2, group VII Activates platelet activating factor (PF4) 19.93\n NOS2A Nitric oxide synthase 2a, inducible *aka* iNOS; produces NO which is bacteriocidal/tumoricidal 23.53\n PLAUR Plasminogen activator, urokinase receptor Ligand-specific cell surface receptor for UPA; localizes and promotes plasmin formation 15.59\n PTGS2 Prostaglandin-endoperoxide synthase 2 Pro-inflammatory; regulates angiogenesis and cell migration 17.92\n PTPRC Protein tyrosine phosphatase, receptor type, C An essential regulator of T- and B-cell antigen receptor signaling; suppresses JAK kinases 11.89\n SERPINE1 Serpin peptidase inhibitor, clade E Interacts with tissue plasminogen activator to regulate fibrinolysis; inhibits PLAU 22.95\n TGFB1 Transforming growth factor, beta 1 Pro- and anti-inflammatory activity; anti-apoptotic 13.55\n TIMP1 TIMP metallopeptidase inhibitor 1 Inhibitors of matrix metalloproteinases; transcriptionally induced by cytokines and hormones 15.11\n TNF Tumor necrosis factor Pro-inflammatory TH~1~ cytokine, primary mediator of immune response and regulation 20.65\n TNFSF5 CD40 ligand Ligand for CD40; expressed on T-cells; regulates B-cell function by engaging CD40 17.61\n TNFSF6 Fas ligand (TNF superfamily, member 6) Ligand for FAS antigen; critical in triggering apoptosis 21.00\n TNFSF13B Tumor necrosis factor (ligand) superfamily, member 13b B cell activating factor, TNF family 15.46\n TNFRSF13B Tumor necrosis factor receptor superfamily, member 13b Controls T-cell-dependent B-cell antibody responses 20.81\n VEGF Vascular endothelial growth factor Produced by monocytes 23.07\n\nData analysis\n-------------\n\nEach PCR reaction contained primer/probe sets for the target gene and 18S RNA, used as the internal control. ", "The difference between the fluorescence C~T~ for the target and the internal endogenous control (18S) is presented as a ΔC~T~ value. ", "Increases or decreases in the target mRNA concentration correspond to lower or higher ΔC~T~ values, respectively, at approximately 2-fold concentration change per ΔC~T~ unit. ", "The C~T~ reporting system and estimation of relative gene expression is well described in the literature (Livak and Schmittgen, [@B29]). ", "ΔC~T~ values above 23 should be interpreted with caution, because they correspond to gene expression levels at or below the linear range of the assay. ", "Statistical measures were determined using Enterprise Guide version 2.05.89 (SAS Institute, Inc., Cary, NC). ", "The Anderson-Darling test and the Shapiro-Wilk test were used to determine whether the gene expression data fit a normal distribution. ", "Student\\'s *t*-tests were performed to determine *P* values.", "\n\nResults {#s3}\n=======\n\nAltered gene expression in unstable RA patients compared to healthy subjects\n----------------------------------------------------------------------------\n\nGene expression levels were measured in whole blood samples collected from 18 unstable patients with RA maintained on DMARD therapy. ", "Of a total of 48 gene products analyzed, 13 demonstrated very low or undetectable levels among the study subjects. ", "These genes (CSF2, CSF3, CXCL2, F3, IL1A, IL2, IL4, IL6, IL12B, IL13, MMP3, NOS2A, and PLAUR) were not included in further analysis. ", "Of 35 inflammation-related genes examined, these unstable RA patients exhibited increased expression of 25 genes (B7, C1QA, CD14, CD19, CD4, CD8A, CXCL1, HMOX1, HSPA1A, ICAM1, IL10, IL15, IL18, IL18BP, IL1RN, IL1B, MMP9, PTGS2, PTPRC, SERPINE1, TGFB1, TIMP1, TNF, TNFSF13B, TNFSF6, and VEGF) and decreased expression of 1 gene (CD19) compared to healthy controls (*P* \\< 0.05) (Table [3](#T3){ref-type=\"table\"}, Figure [1A](#F1){ref-type=\"fig\"}). ", "MMP9, HSPA1A, SERPINE1, and TGFB exhibited the greatest increases in mean level of expression in RA patients compared to healthy subjects. ", "Changes in expression of each individual gene averaged over all patients in the unstable RA patient group and compared to average gene expression in the healthy control population are depicted in Figure [1A](#F1){ref-type=\"fig\"}.", "\n\n###### \n\n**Single time point gene expression analysis in RA patients unstable on DMARD therapy, stable on DMARD therapy, and stable on combination therapy**.", "\n\n **Gene name** **Relative expression (fold change)[^a^](#TN1){ref-type=\"table-fn\"}** ***P* value[^b^](#TN2){ref-type=\"table-fn\"}** \n --------------- ----------------------------------------------------------------------- ----------------------------------------------- ------ -------------- -------------- ---------------------------------------\n B7 1.24 1.07 0.75 **0.0475** 0.5217 **0.0100**\n C1QA 2.42 1.10 1.52 \\<**0.0001** 0.5567 **0.0251**\n CD14 2.25 1.47 1.10 \\<**0.0001** **0.0006** 0.3615\n CD19 0.64 0.54 0.68 **0.0090** \\<**0.0001** **0.0132**\n CD3Z 1.01 0.81 0.89 0.9495 **0.0160** 0.1683\n CD4 1.47 1.13 1.04 **0.0012** 0.2490 \\<**0.0001**\n CD8A 1.54 0.87 0.81 **0.0062** 0.3299 0.1707\n CXCL1 1.89 1.43 0.75 \\<**0.0001** **0.0016** **0.0263**\n HLA-DRB1 0.69 0.32 0.92 0.4900 **0.0379** 0.9067\n HMOX1 2.25 1.49 1.30 \\<**0.0001** **0.0003** **0.0385**\n HSPA1A 2.62 1.77 1.15 \\<**0.0001** \\<**0.0001** 0.2548\n ICAM1 2.25 1.44 1.07 \\<**0.0001** **0.0003** 0.5007\n IFNA2 1.25 1.06 0.62 0.1295 0.7230 **0.0004**\n IFNG 1.24 0.84 ND 0.0614 0.0795 [^**\\***^](#TN3){ref-type=\"table-fn\"}\n IL10 1.34 0.93 0.61 **0.0206** 0.5005 \\<**0.0001**\n IL15 1.43 0.94 1.33 **0.0095** 0.6242 **0.0447**\n IL18 2.14 1.41 1.09 \\<**0.0001** **0.0010** 0.4815\n IL18BP 1.60 1.18 0.78 \\<**0.0001** 0.0644 **0.0025**\n IL1RN 2.48 1.84 0.68 \\<**0.0001** \\<**0.0001** **0.0006**\n IL1B 2.24 1.69 0.93 \\<**0.0001** \\<**0.0001** 0.5218\n IL5 1.26 0.97 0.61 0.0857 0.8539 \\<**0.0001**\n IL8 1.01 1.06 2.69 0.9721 0.7469 \\<**0.0001**\n MMP9 3.45 2.04 1.19 \\<**0.0001** **0.0001** 0.3469\n PLA2G7 1.14 0.92 0.92 0.4591 0.5298 0.6262\n PTGS2 2.23 1.26 0.78 \\<**0.0001** **0.0248** **0.0136**\n PTPRC 1.49 1.25 0.67 \\<**0.0001** **0.0138** 0.6788\n SERPINE1 2.56 1.21 1.12 \\<**0.0001** 0.1680 0.4726\n TGFB1 2.52 1.59 0.96 \\<**0.0001** \\<**0.0001** 0.5757\n TIMP1 2.02 1.35 1.08 \\<**0.0001** **0.0010** 0.4304\n TNF 1.90 1.11 0.88 \\<**0.0001** 0.3426 0.3158\n TNFRSF13B 0.80 0.61 0.60 0.1674 **0.0004** **0.0028**\n TNFSF13B 1.97 1.35 1.47 \\<**0.0001** **0.0137** **0.0017**\n TNFSF5 1.17 0.97 0.62 0.1691 0.7831 \\<**0.0001**\n TNFSF6 1.70 0.79 0.93 **0.0008** 0.0839 0.6686\n VEGF 1.38 0.84 ND **0.0028** **0.0474** [^\\*^](#TN3){ref-type=\"table-fn\"}\n\nΔCT values of genes expressed in RA subjects were compared to those from healthy blood donors.", "\n\nProbability of a difference between groups was determined by Student\\'s t-test. ", "P value represents comparison of gene expression from healthy blood donors.", "\n\nND indicates data not determined.", "\n\nIndicates statistics not analyzed.", "\n\nBold values are statistically significant P values.", "\n\n{#F1}\n\nChanges in gene expression during DMARD therapy\n-----------------------------------------------\n\nWhole blood was collected from 26 RA patients with stable clinical examinations after at least 12 weeks of DMARD therapy. ", "Serum levels of CRP in these patients ranged from 0.05 to 2.7 mg/L (average 0.35 mg/L), consistent with low systemic levels of inflammation. ", "Of 35 inflammation-related genes examined, stable RA patients maintained on DMARD therapy exhibited increased expression of 14 genes (CD14, CXCL1, HMOX1, HSPA1A, ICAM1, IL18, IL1RN, IL1B, MMP9, PTGS2, PTPRC, TGFB1, TIMP1, and TNFSF13B) and decreased expression of 5 genes (CD19, CD3Z, HLA-DRB1, TNFRSF13B, and VEGF) compared to healthy controls (*P* \\< 0.05) (Table [3](#T3){ref-type=\"table\"}, Figure [1B](#F1){ref-type=\"fig\"}). ", "Expression of B7, C1QA, CD4, CD8A, IL10, IL15, IL18BP, SERPINE1, TNF, and TNFSF6 were normalized compared to unstable RA patients maintained on DMARD therapy (Figures [1A,B](#F1){ref-type=\"fig\"}).", "\n\nChanges in gene expression during combination therapy\n-----------------------------------------------------\n\nWhole blood was collected from 20 RA patients with stable clinical examinations after 12 weeks of treatment with combination therapy (a DMARD and an anti-TNF-α agent). ", "Of 35 inflammation-related genes examined, 6 genes (C1QA, CD4, HMOX1, IL15, IL8, and TNFSF13B) exhibited increased expression and 11 genes (B7, CD19, CXCL1, IFNA2, IL10, IL18BP, IL1RN, IL5, PTGS2, TNFRSF13B, and TNFSF5) demonstrated decreased expression compared to healthy controls (*P* \\< 0.05) (Table [3](#T3){ref-type=\"table\"}, Figure [1C](#F1){ref-type=\"fig\"}). ", "The increased expression of 15 genes present in the unstable RA patient group on DMARD therapy was normalized in stable RA patients on combination therapy (Figures [1A,C](#F1){ref-type=\"fig\"}). ", "These genes included CD14, CD8A, HSPA1A, ICAM1, IL18, IL1B, MMP9, PTPRC, SERPINE1, TGFB1, TIMP1, TNF, and TNFSF6.", "\n\nAmong 20 patients receiving combination therapy, patients receiving infliximab (*N* = 10) exhibited decreased expression of seven genes (B7, CXCL1, IL10, IL1RN, IL5, PTPRC, and TNFSF5) and increased gene expression of one gene (C1QA) compared to healthy controls, whereas patients receiving etanercept (*N* = 10) exhibited increased expression of three genes (HMOX1, IL8, and TNFSF13B) and decreased expression of nine genes (CD8A, IL10, IL18BP, IL1RN, IL5, PTGS2, PTPRC, TNFRSF13B, and TNFSF5 compared to healthy controls (*P* \\< 0.05) (Table [4](#T4){ref-type=\"table\"}). ", "RA patients stable on etanercept exhibited robust increases in IL8 expression (5.70-fold change compared to healthy controls, *P* \\< 0.0001, Table [4](#T4){ref-type=\"table\"}).", "\n\n###### \n\n**Single time point gene expression analysis of stable RA patients on DMARD therapy and anti-TNF-α therapy with either infliximab or etanercept**.", "\n\n **Gene name** **Relative expression (fold change)[^a^](#TN4){ref-type=\"table-fn\"}** ***P* value[^b^](#TN5){ref-type=\"table-fn\"}** \n --------------- ----------------------------------------------------------------------- ----------------------------------------------- ------------ --------------\n B7 0.67 0.92 **0.0024** 0.4999\n C1QA 2.02 0.99 **0.0014** 0.9696\n CD14 1.14 1.04 0.3689 0.7978\n CD3Z 0.89 0.94 0.2948 0.5865\n CD4 1.03 1.06 0.8423 0.6788\n CD8A 1.04 0.58 0.8418 **0.0063**\n CXCL1 0.68 0.79 **0.0284** 0.1727\n HMOX1 1.26 1.40 0.1278 **0.0451**\n HSPA1A 1.15 1.09 0.3865 0.5708\n ICAM1 0.98 1.13 0.8911 0.3179\n IL10 0.68 0.64 **0.0183** **0.003**\n IL15 1.43 1.20 0.0555 0.3005\n IL18 0.90 1.25 0.4656 0.0925\n IL18BP 0.82 0.73 0.0526 **0.003**\n IL1RN 0.61 0.73 **0.0014** **0.0203**\n IL1B 0.78 1.07 0.078 0.6039\n IL5 0.66 0.46 **0.0101** \\<**0.0001**\n IL8 1.50 5.70 0.1585 \\<**0.0001**\n MMP9 1.20 1.06 0.461 0.7911\n PLA2G7 0.86 1.07 0.4403 0.7478\n PTGS2 0.82 0.71 0.1617 **0.012**\n PTPRC 0.75 0.63 **0.0123** \\<**0.0001**\n SERPINE1 1.21 0.94 0.286 0.7372\n TGFB1 1.02 0.88 0.8391 0.1836\n TIMP1 1.02 1.10 0.8459 0.4071\n TNF 0.83 0.81 0.2149 0.1582\n TNFRSF13B 0.76 0.51 0.1389 **0.0004**\n TNFSF13B 1.37 1.49 0.0592 **0.0117**\n TNFSF5 0.59 0.62 **0.0002** **0.001**\n TNFSF6 1.09 0.75 0.6164 0.102\n\nΔCT values of genes expressed in RA subjects were compared to those from healthy blood donors.", "\n\nProbability of a difference between groups was determined by Student\\'s t-test. ", "P value represents comparison of gene expression from healthy blood donors.", "\n\nBold values are statistically significant P values.", "\n\nDiscussion {#s4}\n==========\n\nIdentification of easily accessible and reliable biomarkers of inflammatory disease activity to diagnose and monitor disease progression in individual patients over time is an attractive therapeutic goal. ", "Here, we demonstrate that gene expression analysis of whole blood using qRT-PCR can be used to assess disease activity of RA patients.", "\n\nPatients with unstable RA demonstrated increased peripheral blood expression of numerous proinflammatory cytokines, including IL1B, TNF, and IL18, and increased expression of genes whose protein products have been shown to contribute to synovial deterioration (including MMP) compared to healthy human control subjects. ", "These cytokines have been previously shown to be upregulated in the synovium or serum in RA (Brennan et al., [", "@B10]; Gracie et al., [", "@B16]; Feldmann and Maini, [@B14]; Joosten et al., [", "@B23]; Klimiuk et al., [", "@B26]; Paramalingam et al., [", "@B40]; Shao et al., [", "@B46]; Volin and Koch, [@B52]). ", "In comparison, increases in inflammatory gene expression are diminished in patients with stable disease on either DMARD alone or combined DMARD and anti-TNF-α therapy. ", "These results indicate that clinical assessments of overall disease stability correlate with an overall reduction in peripheral inflammatory gene expression.", "\n\nUnstable RA patients in the current study also exhibited increased expression of several cytokines which are generally thought to have an anti-inflammatory effect, including IL10, IL1RN, and TGFB1 (Katsikis et al., [", "@B25]). ", "These have been reported to be elevated in the synovium and in peripheral blood samples from RA patients (Katsikis et al., [", "@B25]; Ohshima et al., [", "@B37]; Mesko et al., [", "@B34]; Tukaj et al., [", "@B48]; Meugnier et al., [", "@B35]), where they may serve to mitigate the inflammatory process. ", "Further, expression of IL10 and IL1RN in stable RA patients on either DMARD or combination DMARD and anti-TNF-α therapy was the same (DMARD) or reduced (combination) compared to healthy controls (Table [3](#T3){ref-type=\"table\"}). ", "It is speculated that as levels of proinflammatory cytokines are reduced during effective anti-TNF-α therapy, corresponding levels of anti-inflammatory cytokines are also reduced.", "\n\nOur data, however, also demonstrate that despite stable clinical assessments, RA patients on DMARD therapy alone continue to exhibit increased expression of some inflammatory genes, suggesting that subclinical inflammation is still present in these patients. ", "Stable RA patients on combination therapy demonstrate a greater reduction in inflammatory gene expression compared to both unstable and stable RA patients on DMARD alone. ", "Specifically, patients on combination therapy exhibit fewer increases in proinflammatory markers compared to patients on DMARD alone, and decreased expression of a number of proinflammatory genes even compared to healthy controls. ", "Our findings suggest that even when chronic inflammatory disease is clinically stable, inflammatory pathways may still be active. ", "These pathways could contribute to long-term development of comorbidities associated with RA. ", "Further, variations in the inflammatory profile differ in patients on DMARD alone versus combined DMARD and anti-TNF-α therapy, and combination therapy appears to confer a greater overall anti-inflammatory effect compared to DMARD therapy. ", "Whether changes in the expression of particular genes may be useful biomarkers to assess overall disease activity remains to be determined, and is an area of ongoing research.", "\n\nChanges in gene expression with anti-TNF-α therapy were largely similar between patients receiving infliximab and etanercept, with the notable exception of significantly increased expression of the chemokine IL8 in patients on etanercept compared to healthy controls and to RA patients on DMARD or infliximab therapies (Table [3](#T3){ref-type=\"table\"}). ", "IL8 recruits neutrophils and T cells to the synovium and stimulates angiogenesis (reviewed in Badolato and Oppenheim, [@B5]). ", "The mechanisms and long-term consequences of IL8 induction during anti-TNF-α treatment are unclear and further studies are warranted.", "\n\nDespite variable disease activity and treatment modalities, the expression of several proinflammatory genes was increased among all three experimental groups compared to healthy controls, including HMOX1 and TNFSF13B (Table [3](#T3){ref-type=\"table\"}). ", "HMOX1 is a heme oxygenase that reduces levels of the pro-oxidant heme to reduce overall oxidative stress. ", "Its expression is induced by a variety of noxious stimuli, including hypoxia, inflammation, and environmental stressors (Otterbein et al., [", "@B39]). ", "TNFSF13B is increased by TNF-α and IFN-γ in the synovium (Alsaleh et al., [", "@B2]; Assi et al., [", "@B4]; Woo et al., [", "@B53]). ", "Sustained elevations of these genes may be associated with the inflammation in the synovium and serum during the development and progression of RA. ", "TNFSF13B is also known as B-cell activating factor (BAFF). ", "Increased TNFSF13B can be contrasted with the expression of CD19, a marker of B cells, which was consistently suppressed relative to healthy controls among all three RA groups, as has been previously reported (Holden et al., [", "@B18]).", "\n\nAssessment of peripheral blood gene expression provides an easily accessible population of inflammatory cells in which to study relative changes in cytokine expression over time. ", "However, it is important to consider that in any given individual, relative proportions of each blood cell type may vary markedly. ", "In this setting, overall changes in peripheral blood gene expression may be significantly influenced by changes in the proportion of blood cell types and their corresponding transcription profiles. ", "For example, we observed upregulation of CD14, a monocyte-specific marker, in unstable RA patients treated with DMARD (Table [3](#T3){ref-type=\"table\"}). ", "CD14 expression was attenuated in stable RA patients on DMARD therapy and was normalized in stable RA patients on anti-TNF-α therapy (Table [3](#T3){ref-type=\"table\"}). ", "In our unstable RA patient population, therefore, an increased proportion of circulating monocytes may have influenced the expression levels of some cytokines.", "\n\nIL-6 is a proinflammatory cytokine that stimulates differentiation of B-cells into antibody-producing plasma cells and contributes to the release of metalloproteases from tissue fibroblasts (Badolato and Oppenheim, [@B5]). ", "Increases in IL-6 protein levels in the synovium and the serum have been demonstrated in RA patients, particularly associated with acute inflammation early in the disease process (Houssiau et al., [", "@B19]; Hovdenes et al., [", "@B20]; Madhok et al., [", "@B31]). ", "Our results demonstrate very low or undetectable levels of IL6 mRNA from peripheral blood cells of stable RA patients treated with DMARD therapy and in stable RA patients treated with combination DMARD and anti-TNF-α therapy, suggesting significant attenuation of the proinflammatory cytokine cascade that contributes to the progression of RA. ", "Expression of IL-6 is tightly regulated, and changes in gene transcription may precede measurable changes in protein secretion (DeFuego and Remick, [@B12]). ", "High serum levels of IL-6 despite low levels of IL6 mRNA expression within mononuclear cells isolated from the peripheral blood and from the synovial fluid in RA patients suggest that high circulating proinflammatory cytokine levels do not necessarily reflect increases in gene expression within inflammatory cell populations (Vazquez-Del Mercado et al., [", "@B50]). ", "Our study examines mRNA levels of IL6, which may not correspond to circulating levels of the protein product. ", "IL-6 within the joint space is derived from synovial fibroblasts (Park and Pillinger, [@B41]; Verweij and Vosslamber, [@B51]); high levels of circulating IL-6 may derive from tissues rather than from circulating mononuclear cells. ", "Finally, previous studies have shown no differences in IL-6 protein or mRNA transcript levels between early, untreated RA patients and chronic RA patients previously treated with DMARD (Vazquez-Del Mercado et al., [", "@B50]). ", "Methotrexate, for example, has been shown to inhibit IL-6 production in peripheral blood cells (Aggarwal and Misra, [@B1]). ", "All three patient groups in the current study were treated with DMARD therapy which may suppress gene expression of IL6 even in the setting of active clinical disease. ", "Finally, circulating levels of IL-6 follow a circadian rhythm in both healthy subjects and RA patients (Knudsen et al., [", "@B27]; Perry et al., [", "@B42]); differences in sampling time between patients in this study may have impacted our measurement of IL6 levels in the overall study population. ", "Further investigation regarding the significance of low levels of IL6 in these unstable patients is warranted.", "\n\nHerein, we show that reduction of inflammatory gene expression levels differ between stable patients on DMARD and combined DMARD and anti-TNF-α therapies. ", "Since most genes in healthy subjects exhibit limited dynamic ranges of expression, we believe that in our study populations, differences in gene expression levels may reflect disease activity. ", "The current findings suggest that these peripheral blood biomarkers correlate with clinical status, and may therefore provide adjunctive information about the efficacy of various treatments for RA. ", "These biomarkers may also allow for assessment of the efficacy of particular RA treatments, including anti-TNF-α therapies. ", "Future studies to determine peripheral blood biomarkers that may predict individual patient responses to a particular systemic therapy may provide assistance with clinical decision making.", "\n\nConflict of interest statement\n------------------------------\n\nThe authors have read the journal\\'s policy and have the following conflicts. ", "John Cheronis, David Trollinger, Danute Bankaitis-Davis, and Michael Bevilacqua are employees of Source MDx. ", "Source MDx only helped to carry out high-throughput qRT-PCR analysis of whole blood samples. ", "The company was not involved in sample collection and data interpretation, decision to publish, or preparation of the manuscript. ", "This does not alter the authors\\' adherence to all the *Frontiers in Inflammation* policies on sharing data and materials.", "\n\nThe authors have no special acknowledgements to make. ", "Brian Kotzin is currently an employee of Amgen, Inc. but did not take up this position during the completion of the study.", "\n\n[^1]: Edited by: Masaaki Murakami, Osaka University, Japan\n\n[^2]: Reviewed by: Sandra Sacre, University of Sussex, UK; Daisuke Kamimura, Osaka University, Japan\n\n[^3]: This article was submitted to Frontiers in Inflammation, a specialty of Frontiers in Immunology.", "\n\n[^4]: †These authors equally contributed to this work.", "\n" ]

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[ "The first Disney Skyliner gondola support beam has now been topped off with the mount that will hold the cable used to transport the gondola cars.", "\n\nHere’s a look back at the first stage of the beam construction." ]

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[ "Ultra.", "Rock Remixed\n\nUltra. ", "Rock Remixed is a mixed dance/rock compilation album from Ultra Records. ", "It was mixed by Tommie Sunshine and released on March 20, 2007.", "\n\nTrack listing \nDisc one:\n\"The Only Difference Between Martyrdom and Suicide Is Press Coverage [Tommie Sunshine's Brooklyn Fire Retouch]\" - Panic! ", "at the Disco\n\"Wine Red [Tommie Sunshine's Brooklyn Fire Retouch]\" - The Hush Sound\n\"Jealous Girls [Tommie Sunshine Mix]\" - The Gossip\n\"Tony the Beat [T.S. 12\" Maxi Vocal]\" - The Sounds\n\"Night on Fire [Tommie Sunshine's Brooklyn Fire Retouch]\" - VHS or Beta\n\"Mama's Room [Tommie Sunshine's Brooklyn Fire Retouch]\" - Under the Influence of Giants\n\"Here (In Your Arms) [TS 12\" Remix]\" - Hellogoodbye\n\"Emotion Commotion\" - Glitch\n\"Straight to Video [TSMV Remix]\" - Mindless Self Indulgence\n\"Lips Like Morphine [Tommie Sunshine's Brooklyn Fire Retouch]\" - Kill Hannah\n\"23 Minutes in Brussels [Tommie Sunshine's Brooklyn Fire Retouch]\" - My Robot Friend\n\"Limit of Your Mind\" - Tommie Sunshine\n\nDisc two:\n\"Dance Among the Ruins\" - Tommie Sunshine\n\"Disko [Tommie Sunshine's Brooklyn Fire & Brimstone Dub] - Shiny Toy Guns \t\n\"Body Jack [Tommie Sunshine Remix] - Marc Romboy\n\"Dance Dance [Tommie Sunshine's Brooklyn Fire Retouch] - Fall Out Boy\n\"I Just Wanna Live [Tommie Sunshine's Brooklyn Fire Retouch] - Good Charlotte\n\"Running From\" - John Acquaviva & Madox\n\"Let the Poison Spill from Your Throat [Tommie Sunshine's 'Let The Clock Punch' Redux] - The Faint\n\"Boys Wanna Be Her [Tommie Sunshine's Brooklyn Fire Retouch]\" - Peaches\n\"Tokyo Pollution\" - Tommie Sunshine\n\"At Home He's a Tourist [Tommie Sunshine's Brooklyn Fire Retouch]\" - Gang of Four\n\"Will You [Tommie Sunshine Remix]\" - P.O.D.\n\"Y Control [Tommie Sunshine Remix]\" - Yeah Yeah Yeahs\n\nReferences\n\nExternal links\n\n Ultra.", "Rock Remixed at Amazon\n\nCategory:2007 compilation albums\nCategory:Ultra Records albums" ]

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[ "Sen. Bernie Sanders Bernie SandersJacobin editor: Primarying Schumer would force him to fight Trump's SCOTUS nominee Trump campaign plays up Biden's skills ahead of Cleveland debate: 'He's actually quite good' Young voters backing Biden by 2:1 margin: poll MORE (I-Vt.) ", "said in a tweet Wednesday that President Trump is \"on the wrong side of history\" after his announcement that transgender individuals would not be accepted into the military.", "\n\nTrump's transgender ban announcement comes 69 years to the day after President Truman ordered the racial integration of the U.S. Armed Forces, which Sanders highlighted in his message:\n\nMr. Trump, you are on the wrong side of history. ", "Discrimination has no place in our military or society. ", "We must stand with trans people. ", "pic.twitter.com/pG0i5BxtT3 — Bernie Sanders (@SenSanders) July 26, 2017\n\nADVERTISEMENT\n\nHouse Minority Leader Nancy Pelosi (D-Calif.) also bashed Trump for the move, citing the anniversary of Truman's decision. “", "69 years ago, President Truman desegregated the US Military,\" she tweeted. \"", "This morning, @POTUS turned anti-#trans prejudice into policy.\"", "\n\n“But instead of honoring their patriotism, @POTUS has decided to attack their dignity and the very value of their service,\" she said." ]

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[ "Template-Free Growth of Well-Ordered Silver Nano Forest/Ceramic Metamaterial Films with Tunable Optical Responses.", "\nCurrently, the limitations of conventional methods for fabricating metamaterials composed of well-aligned nanoscale inclusions either lack the necessary freedom to tune the structural geometry or are difficult for large-area synthesis. ", "In this Communication, the authors propose a fabrication route to create well-ordered silver nano forest/ceramic composite single-layer or multi-layer vertically stacked structures, as a distinctive approach to make large-area nanoscale metamaterials. ", "To take advantage of direct growth, the authors fabricate single-layer nanocomposite films with a well-defined sub-5 nm interwire gap and an average nanowire diameter of ≈3 nm. ", "Further, artificially constructed multilayer metamaterial films are easily fabricated by vertical integration of different single-layer metamaterial films. ", "Based upon the thermodynamics as well as thin film growth dynamics theory, the growth mechanism is presented to elucidate the formation of such structure. ", "Intriguing steady and transient optical properties in these assemblies are demonstrated, owing to their nanoscale structural anisotropy. ", "The studies suggest that the self-organized nanocomposites provide an extensible material platform to manipulate optical response in the region of sub-5 nm scale." ]

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[ "Karl Popper blamed Plato for the rise of totalitarianism in the 20th century, seeing Plato’s philosopher kings, with their dreams of ‘social engineering’ and ‘idealism’, as leading directly to Joseph Stalin and Adolf Hitler (via Georg Wilhelm Friedrich Hegel and Karl Marx). ", "In addition, Ayatollah Khomeini is said to have been inspired by the Platonic vision of the philosopher king while in Qum in the 1920s when he became interested in Islamic mysticism and Plato’s Republic. ", "As such, it has been speculated that he was inspired by Plato’s philosopher king, and subsequently based elements of his Islamic Republic on it.", "\n\nToo many among today’s intellectual elite see themselves as our shepherds and us as their sheep. ", "Tragically, too many of us are apparently willing to be sheep, in exchange for being taken care of, being relieved of the burdens of adult responsibility and being supplied with “free” stuff paid for by others." ]

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[ "A Straight Path to Success - The Brilliance of Linear Gaming\n\nWhen it comes to big name, big budget videogames, there seems to be a divide between two very different types of game. ", "The linear, story-driven titles like The Last of Us or Bioshock, and the open-world spectaculars such as Skyrim and GTA. ", "Of course, this is a generalisation of the highest order, but it is something that we apply to just about every game out there. ", "With this generalisation comes another that’s existed for a long while, and is only now beginning to decline: the concept of a linear game being naturally inferior due to its ‘restrictive’ nature. ", "How many times have you heard someone reject Call of Duty due to its linear story mode? ", "Or ignore a game because it doesn’t make any bold (arguably fickle) claims of player choice? ", "Linear games have had a bad reputation throughout the now declining seventh generation of consoles; in my humble opinion, that’s a reputation that hasn’t been well earned. ", "In fact, I’d argue it’s one of the greatest injustices within the collective opinion of the gaming community.", "\n\nIt’s a cruel reputation, and one that games like The Last of Us are working off with their pure and utter brilliance, but for too long now I’ve seen games rejected purely because of their linear, story-cental nature. ", "The Uncharted series is a good example of a game that despite its huge fanbase, still attracts naysayers who claim that the games are too simplistic and highly restrictive. ", "As mentioned, Call of Duty is another series that’s been branded with the ‘linear’ mark, even the fantastic campaign from Call of Duty 4: Modern Warfare. ", "I do understand some of the issues certain gamers have with these games; lack of ‘interactivity’ is typically the key bugbear, or just a general lack of player choice. ", "I’m not really going to disagree with these statements; indeed, any open-world game is going to offer a more direct player to game relationship. ", "But is the desire to own the story and game and make it your own really that important?", "\n\nIt depends on the game, is my answer to that. ", "If I’m playing my favourite game Rome: Total War, I want to carve my own story into the marble. ", "It’s not a game about a specific story, but rather a story that you create; I’d argue that strategy games offer the ultimate form of ‘self-story-creation’, but large scale RPGs do come close. ", "Put simply though, I don’t always want to create my own story - I’ll give a bit more detail on that later. ", "Sometimes, in fact often, I just like to sit back, hold the controller in my hand, and enjoy the ride. ", "Uncharted 2 is the ultimate example of this for me, as it’s the filmic qualities of the game that make it stand out from the pack. ", "Dramatic action scenes, witty and charming dialogue, not to mention a story that would make Indiana Jones proud. ", "The joy of playing it stems not only from interaction with game, but also the satisfying visual and aural elements.", "\n\nSo should I just watch Indy instead? ", "Certainly not! ", "Whether it’s an extremely simple game with minimal interaction, or a complicated strategy or role-playing title, videogames are fantastic specifically because they require an element of commitment and engagement that just doesn’t exist in other media forms. ", "My control over Nathan Drake and his story may be small compared to the degree to which you can control the likes of Niko Bellic and Ezio Auditore, but that comparatively small degree of control is still imperative to the gameplay experience. ", "What makes Uncharted 2 so much better than any Indiana Jones film (that’s right, I said it) is that the player feels a much closer connection with the story and the action, or at least I did. ", "In my opinion, linear games aren’t restrictive due to their closed narrative and single path, they are, in fact, much more effective forms of pure entertainment due to this.", "\n\nBy far the most beneficial element of a linear style is the positive way this form affects stories within games. ", "Many, many videogames struggle to tell a genuinely good story largely due to the fact that the player must always be factored in. ", "Even Uncharted, with its charming tale of lost gold, is severely restricted by the nature of action games. ", "Afterall, it’s a little tricky to take Nathan Drake as a good hearted man after he’s just slaughtered hundreds of men at the player’s hands. ", "The player is, in most games, a huge obstacle that the story has to either leap over or simply ignore. ", "Indeed many linear games in which the player is the story are the most effective: The Stanley Parable, Papers Please. ", "Open-world games, however, have a serious issue with this; The Elder Scrolls and similar games are the best examples of the problem. ", "How can you tell a convincing tale when the player is left to his own devices, doing almost everything he/she can do to obstruct the core narrative?", "\n\nLinear games reduce the impact the player has on the story, thereby making it much improved in structure, delivery and overall presentation. ", "There are numerous examples of highly linear games delivering excellent stories - at least in the generally limited world of video game narrative. ", "The Last of Us is the most recent and most prevalent example; a very linear experience that contains arguably the finest story to be found in a game. ", "In an open-world form, it simply wouldn't have worked; the game is so well paced and thoughtfully constructed that it’s that very linear nature that brings out the very best. ", "Like a good film, The Last of Us has an excellent template and storyboard behind it. ", "Other linear games demonstrate this same fantastic use of story and game design pacing; the original Bioshock being an obvious example. ", "Gears of War and Halo both demonstrate this technique effectively; hell, even Super Mario Bros and Sonic The Hedgehog feature this, even if the story is incredibly simplistic.", "\n\nWhile open-world games can often feel bogged-down by gaming tropes: customisation, side-missions, collectables and unexplained narrative holes, linear games allow for a much more simple, but arguably more effective experience. ", "Modern games have become increasingly able in making players feel strong emotions; whether this be rage, sorrow, grief, joy, or any other emotional state. ", "The nature of linear gaming may place restrictions on the physical actions of a gamer, but I’d argue that it is much more effective at stirring emotions. ", "I can have fun in Titanfall due to a sense of competition and satisfying gameplay, I can enjoy Crusader Kings II because I’m creating my own version of history, but I’ll enjoy Uncharted, Bioshock and The Last of Us because they make me truly feel something inside. ", "That is the ultimate aim of art, and it’s a fantastic side effect of being entertained." ]

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[ "Davis,\nRSF, and Meridian are the three largest shareholders in\nCyanotech Corporation-a company that produces natural\nnutritional supplements made from microalgae. ", "Davis acquired\n19.6% of Cyanotech's outstanding common-stock shares in\n2002, has served as a member of Cyanotech's Board since\n2003, and has been Chairman of the Board since 2011. ", "As of\nMarch 17, 2017, Davis claims beneficial ownership of\napproximately 16.8% of the outstanding common stock.", "\n\nAt some\npoint in 2011, another shareholder wanted to sell its 9.7%\ninterest in Cyanotech. ", "When Davis got wind of the sale, he\ndonated an unprecedented $2.5 million to RSF, who used that\nmoney to buy the shares. ", "Then, by using one of his charitable\nfoundations as a vehicle, Davis transferred additional\nCyanotech shares to RSF while contemporaneously recouping his\nown interest through the open market. ", "As of March 17, 2017,\nRSF holds 16.2% of the outstanding common stock. ", "Davis and\nRSF collectively own 33% of Cyanotech's outstanding\ncommon stock; Meridian owns 13%.", "\n\nDavis\nhad been reporting his ownership interest on short-form\nSchedule 13G-a form reserved for passive investors and\nunavailable to those seeking to control or influence the\nissuer-instead of Schedule 13D-the standard long-disclosure\nform for shareholders owning more than 5% of a company's\noutstanding common stock. ", "In response to Meridian's May\n2016 demand, Cyanotech appointed a special committee to\ninvestigate whether Davis was required to file a Schedule 13D\nbased on his significant ownership interest, position on the\nBoard, and relationship with RSF. ", "Meridian filed its original\ncomplaint against Davis and RSF one week after making the\ndemand, alleging, among other things, that Davis was\ncommitting securities fraud and breaching his fiduciary\nduties to Cyanotech by filing inaccurate Schedules 13G\ninstead of accurate Schedules 13D.[4] In September 2016, the\nspecial committee released its findings, concluding that\n“Davis should be filing his reports . . . ", "under\nSchedule 13D, rather than on the short form Schedule\n13G.” On September 19, 2016, Meridian filed a verified,\nfirst-amended complaint, incorporating the committee's\nfinding;[5] the next day, Davis filed a Schedule 13D.\n\nBecause\nMeridian's first-amended complaint alleged that Davis had\nnot yet filed a Schedule 13D, I dismissed it as moot in light\nof Davis's newly filed disclosure and gave Meridian leave\nto amend.[6] Meridian filed a second-amended complaint,\nthis time alleging that Davis's 13D was inaccurate in at\nleast two respects: (1) he reported that he acquired his\nshares for “investment purposes” instead of his\ngoal to exercise control and influence over Cyanotech; and\n(2) he disclaimed that he and RSF were a group within Section\n13(d)'s meaning.[7] On March 17, 2017, Davis and RSF filed a\njoint, amended Schedule 13D identifying themselves-along with\nSkywords Family Foundation[8]-as a group from that date.", "\n\nThe\nparties then stipulated to give Meridian leave to amend its\ncomplaint a third time to account for the amended Schedule\n13D.[9]\nIn its third-amended complaint, Meridian alleges only two\nviolations of Section 13(d). ", "First, Davis continues to\nviolate Section 13(d) by representing that he acquired his\ninterest in Cyanotech for “investment purposes”\nrather than to exercise control and influence. ", "Second, Davis\nand RSF continue to violate Section 13(d), despite their\namended Schedule 13D, because they do not acknowledge that\nthey were a statutory group prior to March 17, 2017. ", "Davis\nand RSF now move to dismiss both claims.", "\n\nDiscussion\n\nA.\nMotion-to-dismiss standard\n\nFederal\nRule of Civil Procedure 8 requires every complaint to contain\n“[a] short and plain statement of the claim showing\nthat the pleader is entitled to relief.", "”[10] While Rule 8\ndoes not require detailed factual allegations, the properly\npled claim must contain enough facts to “state a claim\nto relief that is plausible on its face.", "”[11] This\n“demands more than an unadorned,\nthe-defendant-unlawfully-harmed-me accusation”; the\nfacts alleged must raise the claim “above the\nspeculative level.", "”[12] In other words, a complaint\nmust make direct or inferential allegations about “all\nthe material elements necessary to sustain recovery under\nsome viable legal theory.", "”[13]District\ncourts employ a two-step approach when evaluating a\ncomplaint's sufficiency on a Rule 12(b)(6) motion to\ndismiss. ", "First, the court must accept as true all well-pled\nfactual allegations in the complaint, recognizing that legal\nconclusions are not entitled to the assumption of\ntruth.[14] Mere recitals of a claim's elements,\nsupported only by conclusory statements, are\ninsufficient.[15] Second, the court must consider whether\nthe well-pled factual allegations state a plausible claim for\nrelief.[16] A claim is facially plausible when the\ncomplaint alleges facts that allow the court to draw a\nreasonable inference that the defendant is liable for the\nalleged misconduct.[17] A complaint that does not permit the\ncourt to infer more than the mere possibility of misconduct\nhas “alleged-but not shown-that the pleader is entitled\nto relief, ” and it must be dismissed.[18]\n\nB.\nMeridian has sufficiently pled a cause of action under\nSection 13(d).", "\n\nDavis\nargues that Meridian's third-amended complaint should be\ndismissed for four reasons: (1) Section 13(d) does not imply\na private cause of action outside the context of threatened\ncorporate takeover; (2) Meridian has not shown that it will\nsuffer irreparable harm without the requested injunctive\nrelief; (3) this lawsuit moots Meridian's second claim\nbecause it provides shareholders with the information\nrequired to make informed investment decisions and satisfies\nCongress's intent in passing Section 13(d); and (4) the\nallegations are insufficient to satisfy the Private\nSecurities Litigation Reform Act's (PSLRA) heightened\npleading requirement.[19] RSF incorporates Davis's\narguments into its own motion[20] and adds that public-policy\nand equitable considerations of balancing the hardships do\nnot support the requested injunctive relief.[21]\n\n1.", "\nMeridian may pursue a private cause of action under Section\n13(d) outside the context of a threatened\ntakeover.", "\n\n“Congress\nenacted Section 13(d) in 1968, in response to a sharp\nincrease in corporate takeover bids . . . ", "to provide for full\ndisclosure in connection with cash tender offers and other\ntechniques for accumulating large blocks of equity securities\nof publicly held companies.", "”[22]This “allows\ninvestors to determine the value of the corporation's\nsecurities more accurately and to make more informed\ninvestment decisions.", "”[23]\n\nSection\n13(d) of the Exchange Act requires beneficial owners of more\nthan 5% of an outstanding class of registered securities to\nfile a disclosure statement on a long-form Schedule 13D or\nshort-form Schedule 13G.[24] A group of two or more persons formed\n“for the purpose of acquiring, holding, or disposing of\nsecurities of an issuer” stock is considered a single\nbeneficial owner under the statute.[25] The owner must disclose\ninformation about its background and identity, the source of\nthe funds used to purchase the securities, the purpose of the\npurchase, and the extent of the owner's holdings in the\ntarget company.[26]\n\nSection\n13(d) does not expressly authorize a private right of action,\nbut the United States Supreme Court has recognized “the\npower of federal courts to fashion private remedies for\nsecurities laws violations when to do so is consistent with\nthe legislative scheme and necessary for the protection of\ninvestors . . . ", ".”[27] The Ninth Circuit “has held\nthat an issuer corporation has a private right of action for\ninjunctive relief under Section 13(d) of the Act. ", "Because the\nsole purpose of Section 13(d) is to protect shareholders,\nhowever, the issuer corporation is deemed to act on the\nshareholders' behalf in seeking injunctive relief until\nan accurate Schedule 13D is filed.", "”[28]\n\nThe\nNinth Circuit has not yet extended that right to individual\nshareholders, but the defendants do not dispute\nMeridian's ability to bring this action as an individual\nshareholder.[29]As a practical matter, the issuer is\nlikely in the best position to police its shareholders'\nSchedules 13D and 13G because the Act requires the\ndisclosures to be filed with the issuer; it does not require\ndisclosure to the shareholders.[30] And if the Section's\nwhole purpose is to protect the shareholders by providing\nthem with complete and accurate information to assist them in\nmaking informed investment decisions, an individual\nshareholder should not be precluded from asserting a Section\n13(d) claim.", "\n\nDefendants\nargue that courts recognize a right of action under Section\n13(d) only when a cash tender offer or some other\n“large, rapid aggregation or accumulation of\nsecurities” threatens a change in corporate control,\n[31]\nand because they acquired their interests in Cyanotech years\nago, there is no current threatened change in control. ", "So,\nthey contend, Meridian has the burden of establishing that it\ncan sue under Section 13(d) outside the context of a\nthreatened takeover.[32]\n\nMeridian\nresponds that courts “have found a private right of\naction to exist in multiple situations when necessary to\nremedy an incorrect or incomplete filing of a Schedule\n13D.”[33] It cites to Chevron Corp. v.\nPennzoil Co., [34]Dan River, Inc. v. Unitex Ltd.,\n[35]\nand GAF Corp. v. Milstein[36] for support. ", "In\nChevron, the Ninth Circuit concluded that “a\nreasonable inference could be drawn that Pennzoil's\n[Schedule 13D] was materially misleading because it failed to\nadequately disclose Pennzoil's intent to obtain a board\nposition and exert some level of management influence over\nChevron's operations.", "”[37] The court reversed the\ndistrict court's grant of summary judgment and remanded\nthe case so that Chevron could pursue its Section 13(d) claim\nand seek curative injunctive relief for the allegedly\ninaccurate disclosure.", "\n\nThe\nSecond Circuit held in Milstein that “the\nobligation to file truthful statements is implicit\nin the obligation to file with the issuer, and a\nfortiori, the issuer has standing under Section 13(d) to\nseek relief in the event of a false\nfiling.", "”[38] And in Dan River, the Fourth\nCircuit-placing substantial weight on the holding in\nMilstein-held that, “should Dan River\nestablish that there is a reasonable basis for concluding\nthat the Schedule 13D filed by the defendants is inaccurate,\nincomplete, or misleading . . . ", "the district court may and\nshould grant appropriate injunctive relief and should require\nthe filing of an amended Schedule 13D complying with the\nrequirement of a truthful and complete statement . . .", "\n.”[39]\n\nAll of\nthese cases, however, arose in the context of an express or\nalleged takeover attempt. ", "So, they don't stand for the\nproposition that a Section 13(d) action can be brought beyond\nthat context, but nor do they say that one can't be. ", "What\nI glean from these cases is their focus on the need for\ntruthful and complete Schedules 13D. This focus seems to\nsupport a private right of action for curative injunctive\nrelief even after a change in control has occurred.", "\n\nBut\nwhat I find most compelling is Meridian's common-sense\nargument that to agree with Davis and RSF would be to\n“eviscerate Section 13(d).” ", "Davis and RSF argue\nthat they have collectively owned 33% of Cyanotech's\noutstanding common stock for several years and currently\nexercise actual control in light of Davis's position as\nChairman of the Board, so there can be no future threat of\nusurpation from them. ", "But Meridian alleges that they gained\ntheir controlling share while they were in violation of\nSection 13(d). ", "Agreeing with the defendants, then, is\ntantamount to saying: “If you violate Section 13(d)\nlong enough, you can't be sued under Section\n13(d).” ", "And this cannot be what Congress intended. ", "So,\nin light of the caselaw's focus on truth, accuracy, and\ncompleteness, I find that Meridian may assert a private cause\nof action under Section 13(d).", "\n\n&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.", "\nMeridian has sufficiently alleged that it will continue to\nsuffer irreparable harm ...\n\nOur website includes the first part of the main text of the court's opinion.", "\nTo read the entire case, you must purchase the decision for download. ", "With purchase,\nyou also receive any available docket numbers, case citations or footnotes, dissents\nand concurrences that accompany the decision.", "\nDocket numbers and/or citations allow you to research a case further or to use a case in a\nlegal proceeding. ", "Footnotes (if any) include details of the court's decision. ", "If the document contains a simple affirmation or denial without discussion,\nthere may not be additional text.", "\n\nBuy This Entire Record For\n$7.95\n\nDownload the entire decision to receive the complete text, official citation,\ndocket number, dissents and concurrences, and footnotes for this case." ]

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[ "For indispensable reporting on the coronavirus crisis, the election, and more, subscribe to the Mother Jones Daily newsletter.", "\n\nI haven’t read Erik Brynjolfsson and Andrew McAfee’s Race Against the Machine yet, but Matt Yglesias has and he says that one of their analogies has changed the way he thinks about technological progress. ", "Basically, if something improves x% per year, then the level of change looks small at first but explodes later, even though the actual rate of change has stayed the same the entire time:\n\nThe point of this, in terms of technological progress, is that we’ve gotten so accustomed to Moore’s Law that we sometimes overlook the implication that the deeper we get into the chessboard, the bigger the changes. ", "We all know that computers advanced a lot between 1991 and 2011, but we should expect the scale of change over the next 20 years to dwarf those changes. ", "This is a straightforward application of a well-known principle and some pretty basic math, but it’s usually not discussed in quite the right way. ", "We think we’re used to the idea of rapid improvements in information technology, but we’re actually standing on the precipice of changes that are much larger in scale than what we’ve seen thus far.", "\n\nThis gives me an excuse to make the exact same point in a different way, specifically about the possibility of creating a computer with human-level intelligence. ", "Suppose that in 1950 the fastest computer on the planet had about a trillionth the computing power of a human brain, and suppose also that computing power increases 1000x every 20 years. ", "Here’s what things would look like:\n\n1950: Trillionth\n\n1950: Trillionth 1970: Billionth\n\n1990: Millionth\n\n2010: Thousandth\n\n2024: Tenth\n\n2030: One\n\nIn 1950, true AI would look like a joke. ", "A computer with a trillionth the processing power of the human brain is just a pile of vacuum tubes. ", "In 1970, even though computers are 1000x faster, it’s still a joke. ", "In 1990 it’s still a joke. ", "In 2010 it’s still a joke. ", "In 2024, it’s still a joke. ", "A tenth of a human brain is about the processing power of a housecat. ", "It’s interesting, but no threat to actual humans.", "\n\nSo: joke, joke, joke, joke, joke. ", "Then, suddenly, in the space of six years, we have computers with the processing power of a human brain. ", "Kaboom.", "\n\nHere’s the point: technological progress has been exactly the same for the entire 80-year period. ", "But in the early years, although the relative progress was high, the absolute progress was minute. ", "Moving from a billionth to a trillionth is invisible on a human scale. ", "So computers progressed from ballistics to accounting to word processing to speech recognition, and sure, it was all impressive, but at no point did it seem like we were actually making any serious progress toward true AI. ", "And yet, we were.", "\n\nAssuming that Moore’s Law doesn’t break down, this is how AI is going to happen. ", "At some point, we’re going to go from 10% of a human brain to 100% of a human brain, and it’s going to seem like it came from nowhere. ", "But it didn’t. ", "It will have taken 80 years, but only the final few years will really be visible. ", "As inventions go, video games and iPhones may not seem as important as radios and air conditioners, but don’t be fooled. ", "As milestones, they’re more important. ", "Never make the mistake of thinking that just because the growing intelligence of computers has been largely invisible up to now that it hasn’t happened. ", "It has." ]

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[ "Q:\n\nHow do sprites work?", "\n\nHow do sprites work?", "\nI've seen sprites from old school games like Super Mario Brothers, and wondered how they're animated to make a game.", "\nThey're always presented as one big image map, so how are they used?", "\nFor Mario (as an example) are there precalculated image co-ordinates that outline mario, and are swapped between various mario sprites to produce animation?", "\nOr are sprites pre \"cut\" during game initialization using precalculated images co-ordinates and stored in memory somewhere?", "\nObviously I know nothing about game development.", "\n\nA:\n\nhttp://en.wikipedia.org/wiki/Sprite_(computer_graphics)\nThough the article doesn't seem to talk about your specific question, now that I look through it thoroughly...\nAnyway, it can probably be done either way, but if I ever had to implement a sprite handler I'd probably go with the splitting method (though as stated in another answer, the coordinate-reference method would probably be easier to implement for a simple animation).", "\n\nA:\n\nOn many older video game and computer systems, sprites were a hardware feature which would overlay small images onto a larger screen. ", " Although the Atari 7800 had a sprite implementation similar to what is described in the Wikipedia article, it was practically unique in that regard. ", " Most sprite systems used a separate group of circuitry for every sprite they could show on a scan line, including a horizontal position trigger and a shift register or other means to send data sequentially. ", " When the raster scan reached the appropriate place on a line, the circuitry would start shifting out the shape data for the sprite.", "\nSome machines (like the Odyssey2) included within the video chip hardware to hold the shapes of all the sprites on the screen. ", " The Atari 2600 only held 8 bits of shape data for each sprite, and required the processor to load the data in real time anywhere it was supposed to change. ", " The most common pattern, however, was for the video chip to clock sprite data from memory automatically. ", " Typically, the hardware would expect the data to be in a particular format or, in some cases, one of two formats.", "\nOn some machines, the number of sprites that can display simultaneously on a frame without CPU intervention equals the number of sprite circuits. ", " Other machines have a small number of sprite circuits, but can display more sprites; as soon as a circuit finishes displaying a sprite, it loads the parameters for the next sprite from memory. ", " The NES fits this pattern.", "\n\n" ]

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[ "Kashanuk\n\nKashanuk (, also Romanized as Kāshanūk) is a village in Zaboli Rural District, in the Central District of Mehrestan County, Sistan and Baluchestan Province, Iran. ", "At the 2006 census, its population was 27, in 7 families.", "\n\nReferences \n\nCategory:Populated places in Mehrestan County" ]

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[ "Geographic Disparities in Liver Allocation and Distribution in the United States: Where Are We Now?", "\nEquitable deceased donor liver allocation and distribution has remained a heated topic in transplant medicine. ", "Despite the establishment of numerous policies, mixed reports regarding organ allocation persist. ", "Patient data was obtained from the United Network for Organ Sharing liver transplant database between January 2016 and September 2017. ", "A total of 20,190 patients were included in the analysis. ", "Of this number, 8790 transplanted patients had a median Model for End-Stage Liver Disease (MELD) score of 25 (17-33), after a wait time of 129 (32-273) days. ", "Patients were grouped into low MELD and high MELD regions using a score 25 as the cutoff. ", "Significant differences were noted between low and high MELD regions in ethnicity (white 77.4% vs 60.4%, Hispanic 8.1% vs 24.5%; P < .001) and highest level of education (grade school 4.8% vs 8.5%, Associate/Bachelor's degree 19% vs 15.7%, P < .001), respectively. ", "Patients in high MELD regions were more likely to be multiply listed if they had a diagnosis of hepatocellular carcinoma (12.1% vs 15%, P = .046). ", "Wait-list mortality (4.8% vs 6%, P < .001) and wait-list time (110 [27-238] vs 156 [42-309] days, P < .001) were greater in the high MELD regions. ", "These results highlight some of the existing disparities in the recently updated allocation and distribution policy of deceased donor livers. ", "Our findings are consistent with previous work and support the liver distribution policy revision." ]

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[ "1. ", "Technical Field\nAircraft instrument and control systems using digital computer and transmitter/receiver systems operating in the area of 4000 MHz.", "\n2. ", "Description of Prior Art\nAll modern commercial aircraft are equipped with navigation instruments that give the pilot information to locate the airport add some are certified to descend to the ground. ", "But when landing an aircraft in low visibility conditions most existing systems do not provide sufficiently accurate data to determine if the aircraft can be stopped in the length of runway remaining. ", "The ability to know this, or, if taking off, know that the aircraft can clear an obstacle at the end of the runway would not only add to safety, but would also contribute to increased revenues for the airlines because they would no longer have to cancel flights due to fog, or waste fuel in holding patterns." ]

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[ " State of New York\n Supreme Court, Appellate Division\n Third Judicial Department\nDecided and Entered: August 7, 2014 518352\n________________________________\n\nIn the Matter of the Claim of\n WALTER W. McCARTHY,\n Appellant.", "\n MEMORANDUM AND ORDER\nCOMMISSIONER OF LABOR,\n Respondent.", "\n________________________________\n\n\nCalendar Date: June 9, 2014\n\nBefore: Lahtinen, J.P., Stein, McCarthy, Rose and Egan Jr., JJ.", "\n\n __________\n\n\n Glass Krakower, LLP, New York City (Bryan D. Glass of\ncounsel), for appellant.", "\n\n Eric T. Schneiderman, Attorney General, New York City\n(Linda D. Joseph of counsel), for respondent.", "\n\n __________\n\n\n Appeal from a decision of the Unemployment Insurance Appeal\nBoard, filed April 22, 2013, which, among other things, ruled\nthat claimant was disqualified from receiving unemployment\ninsurance benefits because he voluntarily left his employment\nwithout good cause.", "\n\n Claimant took a job as a plumber based on the\nrepresentations of his union business agent as to the hours he\nwould be working, but left the job after it became apparent that\nthose representations had been inaccurate. ", "Prior to quitting,\nclaimant made no effort to address the issue with either the\nemployer or his union (see Matter of Sampica [Commissioner of\nLabor], 252 AD2d 702, 703 [1998]). ", "Dissatisfaction with one's\nwork schedule does not constitute good cause for leaving one's\nemployment, and substantial evidence accordingly supports the\ndecision of the Unemployment Insurance Appeal Board disqualifying\n\f -2- 518352\n\nclaimant from receiving unemployment insurance benefits\n(see Matter of della Croce [Commissioner of Labor], 117 AD3d\n1249, 1249 [2014]; Matter of Hurley, 67 AD3d 1153, 1154 [2009]).", "\nInasmuch as claimant falsely reported when applying for benefits\nthat he had left the job due to a lack of work, substantial\nevidence similarly supports the Board's finding that he had made\na willful misrepresentation to obtain benefits (see Matter of\nDeGennaro [Commissioner of Labor], 68 AD3d 1274, 1275 [2009]).", "\n\n Lahtinen, J.P., Stein, McCarthy, Rose and Egan Jr., JJ.,", "\nconcur.", "\n\n\n\n ORDERED that the decision is affirmed, without costs.", "\n\n\n\n\n ENTER:\n\n\n\n\n Robert D. Mayberger\n Clerk of the Court\n\f" ]

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[ "Here we have two great sets of photos showing records being manufactured. ", "The first set are from 1954 starting with an engineer splicing up a tape. ", "The second set is called “How records are made” from a 1962 Warner Brothers album sleeve.", "\n\n“How records are made” from a 1962 Warner Brothers album sleeve.", "\n\n0 Tumblr 0 Pinterest 0 Reddit 15 StumbleUpon 0 email\n\nComments\n\ncomments\n\n« Retro Muppet Concert Posters You Need Wheels »" ]

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[ "Author Correction: Direct observation of incommensurate magnetism in Hubbard chains.", "\nIn this Letter, the affiliation for Christian Gross should have been 'Max-Planck-Institut für Quantenoptik, Garching, Germany' instead of 'Fakultät für Physik, Ludwig-Maximilians-Universität, Munich, Germany'; this has been corrected online." ]

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[ "SR7\n\nSR7 may refer to:\n\n Six Chuter SR7\n SR postcode area\n Lockheed SR-71 Blackbird\n 21791 Mattweegman\n Sony camcorders\n Soroush Rafiei\n\nSee also \n\nList of highways numbered 7" ]

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[ "Eyecup is a component that provides better contact with the head or glasses. ", "With the right profile of the well adjacent to the eye, improving visibility in the viewfinder. ", "In addition, prevents unwanted light to the viewfinder, which may have an effect on abnormal behavior.", "\n\nBelow is a list of questions and answers regarding this product. ", "You can answer the questions of other users, view posted answers or ask another question. ", "This list is moderated. ", "We encourage you to familiarize yourself with the \"questions and answers\"" ]

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[ "Q:\n\nImage background and text for input submit button - CSS\n\nI'm trying to make a button for my form which has an image background and displays the text on top of the background. ", "Seems very simple but I'm struggling to get the text to appear no matter what I try and struggling after an hour of searching to find someone with a similar problem so assume I'm doing something stupid!.", "\nHere's my CSS:\n#detail-left .cart-button {\n background : url(\"../graphics/cart-button.png\");\n border : none;\n color : transparent;\n height: 48px;\n width: 118px;\n padding: 10px;\n line-height: 48px;\n}\n\nand my html:\n<input class='cart-button' type='submit' value='Add' />\n\nA:\n\nRemove color:transparent. ", "Its making your text transparent give it some color.", "\n\nA:\n\nRemove color : transparent; from your style class, That should work\n#detail-left .cart-button {\n background : url(\"../graphics/cart-button.png\");\n border : none;\n height: 48px;\n width: 118px;\n padding: 10px;\n line-height: 48px;\n}\n\nTry this working fiddle\n\n" ]

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[ "Murder Mystery Dinner\n\n$30.00\n\nJoin us for a Meal and a Murder\n\nSat. ", "March 16th\n\nLocation: Locust Hills Banquet Room\n\nDinner starts at 6:00 PM\n\n$30 per person\n\nPlease reserve your seat before we sell out\n\nAttend the Billionaires’ Club Annual Masquerade Ball and help get this soiree back on track by trading clues with your guests, gathering information, and solving the crime before the masked menace gets away! ", "Evening wear, ball gowns, Venetian masks, suits, and tuxes are what to wear to this high class night of masks and murder. ", "Get ready for a glamorous evening of mystery, intrigue, and murder." ]

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[ "What You Will Learn\n\nGot grilling fever yet? ", "Join us in the Sur La Table kitchen for a fun, hour-long demo and get your grill prepped for flavor! ", "A Sur La Table chef instructor will demonstrate delicious recipes and exciting ways to enhance your grilling experience, using a Himalayan salt slab, cedar plank, and a chili pepper corer and grill rack. ", "Each class costs $5, runs for one hour and everyone will enjoy a generous taste of each dish. ", "Class is only open for 32 enthusiastic grillers (so register quickly!)." ]

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[ "Amber Rudd could clearly picture the briefing document that had been left on her desk in February. ", "Perhaps she ought to have taken a quick peek at it after all. ", "But back then the home secretary hadn’t been entirely sure she had the necessary clearance to read something stamped “official – sensitive” and she had been awfully busy working on other things. ", "So she had just left it in the pile marked “embarrassing documents to be leaked to the Guardian”.", "\n\nThat decision clearly haunted Rudd as she took the platform at a central London community centre to launch her serious violence strategy. ", "This was meant to be her big day out. ", "Her chance to dominate the news agenda for the day and show that the government meant business in tackling the rise in violent crime.", "\n\nInstead it had all gone pear-shaped long before the start. ", "Only the previous day she had gone on TV to assert that the 14% fall in police numbers since 2010 was entirely coincidental, but now it had emerged that the policy wonks in her own department had come to precisely the opposite conclusion. ", "Somehow she was going to have to try and muddle her way through.", "\n\nPolice cuts left out of government's key violent crime strategy Read more\n\nEven on her better days, the home secretary can frequently sound if she has been dosed with large quantities of valium, her delivery a deadened monotone and her expression disengaged. ", "This most definitely was not one of her good days. ", "Rudd looked and sounded as if someone had increased her medication. ", "If she couldn’t physically remove herself from the torment of the ordeal, she could at least remove herself from any of the feelings associated with the experience.", "\n\nShe began by reading out a list of people who had been killed in recent weeks. ", "Names to which she couldn’t put a face as she hadn’t made the time to meet a single victim’s family. “", "People are asking ‘Why? ", "Why? ", "Why?’,” ", "she said. “", "And as home secretary, I have been searching for an answer.” ", "Though not so hard as to actually bother to read all the evidence that her researchers had made the effort to compile for her.", "\n\nRather, after highlighting some other key social issues, she chose to press on by doubling down on her insistence that there was no correlation between violent crime and police numbers. “", "We can’t be distracted by political tit for tat,” she mumbled. “", "I want to hear solutions from other parties, not just cries of ‘cuts, cuts, cuts’.” ", "By now Rudd was so lost she was unable to make the connection that reversing cuts both to police and social care budgets might go some way to making the situation a little better.", "\n\nIn little more than 10 minutes – or 12 seconds for each person who had been knifed to death in London this year – the home secretary had faltered to a close. ", "A hint of panic crossed her face as she invited questions. ", "Inevitably, the first one was on police numbers. ", "How come she had not read the documents, and how come there was no mention of the police in her entire 140-page strategy document?", "\n\nIt was like this, she said unconvincingly. ", "She wasn’t at all sure that the document she hadn’t got round to reading had even been a Home Office document. ", "It could have just been a rogue piece of disinformation slipped in to the department by Russian sleeper agents. ", "Besides which, she wanted her strategy to be be informed by evidence not anecdote. ", "At this half the audience did a double-take. ", "They could have sworn the document she hadn’t read and they had was called “Violent Crime: Latest Evidence of its Drivers”.", "\n\nNow the home secretary went for broke. ", "There weren’t actually more crimes taking place. ", "All that had happened was that more crimes were being reported as previously no one had ever bothered to count the bodies. ", "So we were all actually a lot safer than we had been because we just hadn’t known how much danger we were in. ", "And as this had all happened through a reduction in police numbers it made sense to try to abolish the police force entirely.", "\n\nRudd wisely chose not to take any more questions from the media and scuttled off as quickly as indecently possible. ", "In the time she had been standing, the crime figures had just gone up by one. ", "Though this had been more of a white-collar crime. ", "A crime of gross incompetence." ]

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[ "Nankai Maru\n\nThe MV Nankai Maru was an freighter built by Mitsubishi Shipbuilding & Engineering Company Ltd, Nagasaki, Japan, in 1933 for Osaka Shosen Kaisha.", "\n\nShe was requisitioned by the Imperial Japanese Navy as a transport in late 1941. ", "She participated in the invasion fleets at Midway, Milne Bay (where she was damaged by a bomb), Guadacanal (where she was also damaged by a bomb). ", "She was struck by a dud torpedo from USS Kingfish on 8 December 1942 near Okinotorishima. ", "On 25 December 1943, she was damaged by a torpedo from USS Seadragon near Cape St. George, New Ireland and later collided with the destroyer Uzuki. ", "She was sunk by a torpedo from USS Sealion while travelling from Singapore on 12 September 1944 in the South China Sea east of Hainan Island at 18°42'N, 114°30'E.\n\nCitations\n\nExternal links\nNankai Maru\n\nCategory:1930 ships\nCategory:Auxiliary ships of the Imperial Japanese Navy\nCategory:Ships sunk by American submarines" ]

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[ "J.F.T.I - Live Updates\n\nEVIL EXPOSED!", "\n\nWe recently received a tip off in regards to a convicted sex offenders' Facebook account, the same offender who in a report was named as a 'friend' of the heinous evil serial killer Levi Bellfield. ", "Below, you'll find the link, and the information we've sourced from a news outlet.", "\n\nSuraj Gharu now goes by the Facebook name 'Suraj SG' snd he's currently active despite Facebook's clear rules in the terms and conditions that sex offenders aren't allowed on their platform.", "\n\nSuraj Gharu prayed on young girls who resided in childrens homes, he went on to abduct a 14 year old, engage in sexual acts, to which she wasn't returned.", "\n\nA pervert who abducted a 14-year-old girl from a children’s home and lured her into sexual activity with him has been jailed.", "\n\nSuraj Gharu, 25, was sentenced to five years for sex offences and removing a child from the care of social services.", "Isleworth Crown Court heard Gharu preyed on the girl by visiting her at the children’s home where she lived.", "\n\nHe befriended her and picked her up to stay with him several times, but did not return her. ", "At his home in Buchan Close, Cowley, Middlesex, he engage in sexual acts with her and tried to entice her into full sex.", "\n\n​His brother, Sunil, 22, made a false police statement to cover up for him. ", "The cleaner of Hayes, Middlesex, was jailed for nine months for perverting the course of justice." ]

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[ "Different invasion phenotypes of Campylobacter isolates in Caco-2 cell monolayers.", "\nThe pathogenesis of campylobacter enteritis is not well understood, but invasion into and translocation across intestinal epithelial cells may be involved in the disease process, as demonstrated for a number of other enteric pathogens. ", "However, the mechanisms involved in these processes are not clearly defined for campylobacters. ", "In this study, isolates were compared quantitatively in established assays with the enterocyte-like cell line, Caco-2, to determine the extent to which intracellular invasion contributes to translocation across epithelial cell monolayers, and whether isolates vary in this respect. ", "Ten fresh Campylobacter isolates were compared and shown to differ in invasiveness by a factor of 10-fold by following their recovery from gentamicin-treated Caco-2 cells grown on nonpermeable tissue-culture wells. ", "Four of these isolates with contrasting invasive ability were also shown to vary in their ability to translocate across Caco-2 cells grown on semipermeable Transwell inserts by a factor >10. ", "However, translocation did not quantitatively correlate with the intracellular invasiveness of these isolates. ", "Isolate no. ", "9752 was poorly invasive but had modest translocation ability, isolate no. ", "10392 was very invasive but did not translocate significantly and remained within the monolayer, isolate no. ", "9519 both translocated and invaded well, whereas, isolate no. ", "235 translocated very efficiently but was poorly invasive. ", "Isolate no. ", "9519 also uniquely caused a transitory flattening of the Caco-2 cells and a possible drop in trans-epithelial electrical resistance (TEER) of the Transwell monolayers, whereas isolate no. ", "235 did not show these effects. ", "Together these data demonstrate that there are significantly different 'invasion' phenotypes among Campylobacter strains involving different degrees of intracellular invasion, and either different rates of transcellular trafficking or, alternatively, paracellular trafficking." ]

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[ "Item response theory analysis applied to the Spanish version of the Personal Outcomes Scale.", "\nThe study of measurements of quality of life (QoL) is one of the great challenges of modern psychology and psychometric approaches. ", "This issue has greater importance when examining QoL in populations that were historically treated on the basis of their deficiency, and recently, the focus has shifted to what each person values and desires in their life, as in cases of people with intellectual disability (ID). ", "Many studies of QoL scales applied in this area have attempted to improve the validity and reliability of their components by incorporating various sources of information to achieve consistency in the data obtained. ", "The adaptation of the Personal Outcomes Scale (POS) in Spanish has shown excellent psychometric attributes, and its administration has three sources of information: self-assessment, practitioner and family. ", "The study of possible congruence or incongruence of observed distributions of each item between sources is therefore essential to ensure a correct interpretation of the measure. ", "The aim of this paper was to analyse the observed distribution of items and dimensions from the three Spanish POS information sources cited earlier, using the item response theory. ", "We studied a sample of 529 people with ID and their respective practitioners and family member, and in each case, we analysed items and factors using Samejima's model of polytomic ordinal scales. ", "The results indicated an important number of items with differential effects regarding sources, and in some cases, they indicated significant differences in the distribution of items, factors and sources of information. ", "As a result of this analysis, we must affirm that the administration of the POS, considering three sources of information, was adequate overall, but a correct interpretation of the results requires that it obtain much more information to consider, as well as some specific items in specific dimensions. ", "The overall ratings, if these comments are considered, could result in bias." ]

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[ "\n\nImplantable nfc Tag - Killah911\nhttp://www.indiegogo.com/projects/the-xnt-implantable-nfc-chip\n\n======\ncodezero\nIs it just as easy to get removed, in case you need to get an MRI?", "\n\n" ]

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[ "First record of Stegomyia albopicta in Turkey determined by active ovitrap surveillance and DNA barcoding.", "\nDespite its confirmed establishment in neighboring Greece and Bulgaria, the presence of the Oriental invasive species Stegomyia albopicta (Skuse) (=Aedes albopictus) has never been confirmed in Turkey. ", "Active surveillance for this container-breeding species was carried out using oviposition traps at 15 discrete sites in the towns of Ipsala (n=8 sites), Kesan (n=5) (Edirne District), and Malkara (n=2) (Tekirdag District) in the Thrace region of northwestern Turkey, from May 23 through November 10, 2011. ", "Eggs collected were reared to the fourth larval instar and adult stages where possible to facilitate integrated morphological and molecular species identification. ", "DNA barcodes (658 bp of the mitochondrial cytochrome c oxidase I [COI] gene) were compared with all four potentially invasive Stegomyia species: St. aegypti, St. albopicta, St. cretina, and St. japonica. ", "Sequences generated for samples collected in Thrace Region were herein confirmed as St. albopicta, the first record of this vector species in Turkey. ", "Eggs of St. albopicta were detected in two discrete localities: (1) In the grounds of a restaurant in Kesan (in week 36), and (2) in the customs area of the Turkish-Greek border at Ipsala (in weeks 32 and 38). ", "Multiple detection of St. albopicta eggs indicates the possible establishment of the species in northwestern Turkey. ", "Finding this important disease vector has implications for public health and requires the implementation of active vector monitoring programs and targeted vector suppression strategies to limit the spread of this invasive vector species in Turkey." ]

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[ "[Medical and psycho-social screening of ageing patients in dental office].", "\nThe demographic changes cause an increasing number of ageing persons laying claim to medical and dental care. ", "They are trying to maintain their habit of regular dental controls. ", "Therefore, the dental care team should be able to recognize early medical and psycho-social deficiencies relevant for oral health. ", "In this way, health status and ressources of elderly persons could be estimated better and failures in oral diagnosis as well as in treatment due to monodisciplinary case analysis could be avoided. ", "This paper presents a systematic medical and psychosocial screening concept for oral care of elderly patients." ]

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[ "For some reason, a state representative in Texas believes that they the right to dictate who business owners allow to use the bathrooms on their property. ", "State Rep. Debbie Riddle (R) has introduced two bills that would criminalize the use of bathrooms by transgender people and seek to punish businesses who allow transgender individuals to use their facilities.", "\n\nThe first piece of legislation, H.B. 1747, would amend existing laws in Texas on disorderly conduct by adding a provision for when someone “enters a public restroom that is designated by a sign for members of the opposite sex of the actor.” ", "It specifies that sex is determined by the individual’s driver’s license.", "\n\nThe other bill proposed by Riddle, H.B. 1748, defines gender as what is “established at the individual’s birth” or “established by the individual’s chromosomes.” ", "Chromosomes would be the “tie-breaker” if there is a mismatch. ", "The bill lays out punishments for both the individual entering the facility and the owner or manager that allows the individual to enter the facility.", "\n\nApparently, the Texas Republican party was remiss to include property rights as a tenet to the party’s platform.", "\n\nThink Progress reported on the proposed punishments for breaking each law:\n\nUnder HB 1748, it would be a Class A misdemeanor for any individual over the age of 13 to “enter a locker room, shower facility, or toilet facility that is designated for use by persons of a gender that is not the same gender as the individual’s gender.” ", "Under Texas law, a Class A misdemeanor shall be punished by a fine of up to $4,000 and up to a year in jail. ", "The bill creates exceptions only for those serving a custodial purpose, providing medical assistance, or accompanying a young child that is not of the same gender. ", "The bill also targets any “operator, manager, superintendent, or other person with authority over a building,” stipulating that they may not allow anyone to enter a locker room, shower facility, or toilet facility that does not match their gender. ", "Any facility owner who does allow such access has committed a state jail felony. ", "Texas law would dictate a minimum of 180 days in prison with a maximum of two years, as well a fine up to $10,000.", "\n\nThis proposed law is deplorable. ", "Why on earth would a politician believe that they have the right to dictate to a business owner who is permitted to use a restroom or locker room in their facilities? ", "Why would a politician think it is appropriate to force a business to discriminate against transgender people?", "\n\nMaybe it’s because, at all levels of government, multitudes of laws have been passed with the intention of preventing businesses from discriminating or to outright encourage discrimination if it is intended to halt abhorrent practices.", "\n\nMany progressives will reply to this article by demanding counter legislation be submitted that requires business owners not to discriminate against transgender individual’s use of facilities in a business. ", "Their answer for government force is more government force coming from a different perspective with which they agree.", "\n\nNeither application of force is morally acceptable. ", "The use of coercion to halt discrimination or to require a business to discriminate are both equal infringements upon property owners’ rights.", "\n\nIt should be up to the property owner to determine if and when they choose to discriminate. ", "Discrimination is essential to any business. ", "For example, businesses require patrons to wear shirts and shoes in order to make the atmosphere more comfortable and to encourage more customers to patronize the business. ", "Just as business owners are free to discriminate by banning individuals from wearing jeans to a high-end restaurant, customers can discriminate against a business by choosing to eat somewhere else.", "\n\nThis same principle should apply to transgender individuals. ", "They should be entitled to the same treatment under natural law as everyone else in society. ", "If a restaurant feels compelled to check a transgender individual’s driver’s license before they can use the restroom, then they should deal with any consequences. ", "It is the business owners, not the politicians, who deal with their customers on a daily basis and have a vested interest in customer service. ", "They should be allowed to do what pleases their customer base as long as it does not harm an individual or their property.", "\n\nCheck out the full archive of Felony Friday!", "\n\nThe Lions of Liberty are on Twitter, Facebook & Google+\n\nReceive access to ALL of our EXCLUSIVE bonus audio content – including “Conspiracy Corner”, “Degenerate Gamblers” and the “League of Liberty Podcast” by joining the Lions of Liberty Pride and supporting us on Patreon!", "\n\nJoin our brand new Facebook Group: The Lions of Liberty Forum" ]

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[ "Sedative/hypnotic dependence: patient stabilization, tolerance testing, and withdrawal.", "\nPhysical dependence to sedative/hypnotic drugs is not an uncommon clinical problem. ", "The withdrawal syndrome is analogous to alcohol withdrawal, except the duration of the syndrome occurs over a longer period of time with the symptoms being less intense than generally encountered with alcohol. ", "The potential for withdrawal reactions is probably greater for the shorter-acting agents than the longer-acting drugs. ", "Potentially dependent sedative/hypnotic users require stabilization of their symptoms initially, followed by tolerance testing. ", "If tolerant, the patients should be withdrawn using either a long-acting sedative/hypnotic (e.g., diazepam) or phenobarbital. ", "Compared to other benzodiazepines and barbiturates, diazepam appears to be the drug of choice for treating dependent patients. ", "Diazepam is rapidly absorbed and distributed to the brain and therefore useful for stabilization and tolerance testing. ", "It is metabolized on chronic administration to a long-acting metabolite, desmethyldiazepam, which makes the drug ideal for a tapered withdrawal schedule." ]

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[ "Last week Gemini founders and perfect human specimens, Cameron and Tyler Winklevoss met with Facebook CEO Mark Zuckerberg to discuss partnering on their new revolutionary idea: a way to connect the world’s economy on a centralized Cryptocurrency network completely backed by blind faith the US dollar.", "\n\nThey called their idea the “Gemini Dollar” and their innocent dream was that their cryptocurrency would be used to bank the unbanked and bring economic freedom to developing countries and the world as a whole. ", "For the greater good, they swallowed their pride and met with Mark Zuckerberg, their archnemesis, for the first time in almost 20 years after their falling out to discuss leveraging the world’s largest social network to bring their Gemini Dollar to the world. ", "After all, what were the odds that Mark would fleece them twice?", "\n\nApparently very high, because immediately following the meeting at Facebook, the potential partnership with the Gemini Dollar was thrown in the trash, and Zuckerberg announced their newest venture: GLOBALCOIN, a unique and original way to bank on the unbanked, take economic freedom away from developing countries, and most importantly, screw over the Winklevoss for sport.", "\n\nZuckerberg waiting for the Winklevoss’ to get back up.", "\n\nPhoto Courtesy of Jumanji\n\nFollowing the GlobalCoin announcement our reporters met with Mr. Cameron Winklevoss at his parents’ home where we found Cameron lying solemnly in his childhood bed, sick to his stomach at having been Zucked yet again. ", "Cameron’s mother brought him and our reporters several bowls of her famous chicken noodle soup and gave her son a kiss on the forehead before leaving. “", "Ah my stupid son,” she whispered lovingly as she closed the door behind her so we could begin the interview.", "\n\nOur reporters wanted to know one thing: why would the Winklevoss twins be so naïve as to trust Zuckerberg again? ", "After all, didn’t they watch The Social Network?", "\n\n…or so they thought.", "\n\nPhoto Courtesy of Gemini\n\nCameron begrudgingly sat up in bed and began his story.", "\n\n“After the Facebook lawsuit was settled we decided to travel the world and find ourselves. ", "Our journey led us to Ibitha (sic) where we learned about Bitcoin after Tyler wanted to experiment with MDMA. ", "Our friend recommended we check out the Silk Road and the rest is history. ", "I can honestly say that Tyler wanting to roll with some blondes was the best thing that ever happened to this family. ", "We held on to our Bitcoin, sparked global Cryptocurrency demand, started Gemini, and became billionaires. ", "We had finally caught up to Mark.”", "\n\nThere’s only one thing that kept them going.", "\n\n(hint: vengeance)\n\n“Sometime between our second and third Burning Man festival we learned how to practice forgiveness,” the perfect jawline continued. “", "We wanted to give Mark a second chance. ", "Let’s get this straight – we still didn’t trust him, but for the greater good of humanity, we put aside our differences and met with him to try and bring the Gemini Dollar to the world. ", "Our intentions were pure, we thought our idea would economically unite us all. ", "We didn’t anticipate Mark ripping off our idea again, creating “GlobalCoin,” and weaponizing Cryptocurrency to become the world’s ultimate global surveillance network.”", "\n\nWhat did the perfect man just say? ", "The shocking revelation hit our reporters harder than Roger Ver realizing he had ruined his life over Bitcoin Cash. ", "Did the Winklevoss twins unwittingly give Mark Zuckerberg the final piece of the puzzle to his master plan of creating his own digital nation and ruling over his daily active users as a supreme dictator? ", "Would we soon be begging for likes on the street in order to earn a few tokens to feed our families?", "\n\nThe Coin Jazeera investigative team learned with the help of “the documents” obtained by our strategic advisor and conspiracy theorist Alex Jones, that with GlobalCoin, “robot lizard person” Mark Zuckerberg would fully complete his transition to God of the New World Order with his four pronged plan.", "\n\nFirst, connect the world. ", "Second, record and log his users conversations to feed the AI (himself). ", "Third, install Facebook Portal listening devices in everyone’s homes. ", "And finally, thanks to the Winklevoss twins’ beautiful naivety, total economic control.", "\n\n“Mining GlobalCoin”\n\nCredit to @cryptograffiti\n\nWith the power of GlobalCoin, Facebook would now be able to dictate who is allowed to spend money and how they spend it. ", "Mr. Zuckerberg also stole the social credit score system from China, and would monitor users’ social media presence online to determine who is a good citizen and who shills EOS. ", "Eventually cash would be banned and made illegal and barter would be outlawed, forcing everyone onto Facebook’s centralized “walled garden.” ", "Bad citizens and anyone with rational free thought would be blacklisted from participating in Facebook’s new world economy and forced to join the dystopian nomadic tribes still using Ethereum Classic in the gulags.", "\n\nTo better understand the situation Coin Jazeera decided to speak with the creator of GlobalCoin himself. ", "After repeated phone calls our reporters finally got through to the offices of Mr. Zuckerberg and after being screened as a legitimate news organization by his three different assistants, we scheduled a meeting with him for the next day in “The Fishbowl,” a special see-through glass room where Mr. Zuckerberg performs nude calisthenics every morning like the beginning of Die Hard 2.", "\n\nWhen we met Mark the next day we had only one question to ask:\n\n“Are you using GlobalCoin and Cryptocurrency to become a God and control the entire world’s economy?”", "\n\nHis answer rocked us to our core.", "\n\n“Yes. ", "But I’m only doing this to torment Tyler and Cameron. ", "My family has been screwing the Winklevii for generations. ", "Look it up.”", "\n\nMay the best man win.", "\n\nThe battle for the free world\n\nHe wasn’t lying. ", "Our investigative team uncovered that the Winklevoss and Zuckerberg families have been feuding for generations. ", "It started in Germany hundreds of years ago with handsome twin brothers Jebadiah and Abraham Winklevoss, who had an idea for a content distribution platform that would revolutionize the world. ", "To help them with this monumental task they enlisted the help of local village thief Johannes Gutenberg. ", "After telling the Winklevoss that he would help them build their machine, he went on to steal the idea and build his own, calling it “The Printing Press,” and stealing all the glory. ", "The Winklevoss brothers were so embarrassed they got into their boat and rowed away to start a new life in America. ", "Johannes Gutenberg, upon becoming the world’s richest inventor, realized the only thing that brought joy to his life was stealing from the Winklevoss’ so he followed them to America, changed his last name to Zuckerberg for anonymity, and set up his descendants to troll their family as a tradition for generations to come.", "\n\nOur reporters couldn’t believe that GlobalCoin, a paradigm shifting technological innovation, a tool that can shape the fate of billions of people’s economic freedom around the world, was being driven by a petty generational family feud that was never resolved between the Winklevoss and the Zuckerbergs.", "\n\nIt is Coin Jazeera’s sincere hope that these families schoolyard fight can be settled before Facebook launches GlobalCoin out of spite and the world turns into a bad episode of Black Mirror.", "\n\nJohannes Zuckerberg\n\nWhere it all began.", "\n\n\n\nUPDATE 7/1/19: Zuckerberg has renamed GlobalCoin to Libra Coin to troll the Winklevoss twins.", "\n\nThis article is satire and for entertainment purposes only.", "\n\nFOOTER AD SPACE FOR SALE\n\nE-MAIL sponsor@coinjazeera.news\n\nSubscribe to Coin Jazeera for articles right to your inbox Email address: Leave this field empty if you're human:" ]

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