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[
"All relevant data are within the paper and its Supporting Information files.",
"\n\nIntroduction {#sec001}\n============\n\n*Mycobacterium caprae* and *M*. *",
"bovis*, both member of the Mycobacterium Tuberculosis Complex (MTC), are the causative agents for bovine tuberculosis (bTB)\\[[@pone.0181157.ref001]\\]. ",
"While *M*. *",
"bovis* is a long known member of the MTC, *M*. *",
"caprae* was primarily described by Aranaz *et al*. ",
"in 1999 in goat samples in Spain \\[[@pone.0181157.ref002]\\]. ",
"Although Austria is listed as bovine tuberculosis free, infections of cattle and red deer with *M*. *",
"caprae* are still a serious problem in the western parts of Austria. ",
"Currently bacterial culture is the \\\"gold standard\\\" in detecting MTC and investigation of up to twelve weeks are necessary to obtain an unambiguous result. ",
"An alternative provides PCR, but due to its relatively high possibility of false negative results, caused by the uneven distribution of mycobacteria in tissue and small amounts which can be used for PCR, molecular diagnostic methods still is an ineligible method to use as final result. ",
"During this study we evaluated a preparation method (Matrixlysis) to eliminate both of the above mentioned methods' disadvantages and create a fast and precise sample preparation and detection method. ",
"Previously, Mann *et al*. ",
"developed a model system in which different pig tissues were spiked with *Listeria monocytogenes* and the so called method ML was tested with different Lysis buffers according to the tissue solubilisation characteristics and the intended detection method \\[[@pone.0181157.ref003],[@pone.0181157.ref004]\\]. ",
"Based on this model system we adapted ML for quantifying gram positive mycobacteria in naturally infected tissue material. ",
"Diagnostic difficulties of TB presenting non visible lesions (NVL) were described by Gabier-Widén *et al*. ",
"and de Lisle *et al*. ",
"in 2009 \\[[@pone.0181157.ref005],[@pone.0181157.ref006]\\]. ",
"They focused on *M*. *",
"bovis* infections causing no macroscopically visible lesions and the resulting problems of inaccurate TB diagnosis. ",
"Because ML is not limited to the quantity of tissue, large amounts of tissue can be used to avoid false negative results in case of very small or non visible lesions. ",
"An alternative to ML could be the previously developed technique using magnetic beads described by Fell *et al*. ",
"\\[[@pone.0181157.ref007]\\]. ",
"This technique relies on mechanical tissue disruption followed by target specific DNA capture, using biotinylated oligonucleotides and magnetic beads. ",
"Another magnetic beads approach was described by Stewart *et al*. ",
"\\[[@pone.0181157.ref008]\\] focusing on Immunomagnetic separation of the whole bacterium by using antibody coated beads. ",
"In this case, mycobacteria were still viable after immunomagnetic separation and therefore could be used for bacterial cultivation. ",
"To differentiate between the known MTC species the GenoType MTBC line probe assays (Hain Lifesciences GmbH, Nehren, Germany) or qPCR in accordance to Reddington *et al*. ",
"\\[[@pone.0181157.ref009]\\] can be used. ",
"Because both methods rely on a single SNP, GenoType MTBC on a T to G substitution on position 1311 in the *gyrB* sequence \\[[@pone.0181157.ref010]--[@pone.0181157.ref012]\\] and Reddington *et al*. ",
"\\[[@pone.0181157.ref009]\\] on a C to T substitution at position 690 in the H37 Rvl*epA* sequence, they need purified *M*. *",
"caprae* DNA which can only be provided by cultivation of the bacteria. ",
"To differentiate between the three alpine *M*. *",
"caprae* subtypes mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU- VNTR) typing is used \\[[@pone.0181157.ref013],[@pone.0181157.ref014]\\]. ",
"Spoligotyping cannot be recommended for the subtyping of the three alpine *M*. *",
"caprae* subtypes due to its limited discrimination \\[[@pone.0181157.ref013]\\]. ",
"A new method, previously described by Domogalla *et al*. ",
"and adapted by Rettinger *et al*. ",
"used the Region of difference four (RD4) to differentiate between three *M*. *",
"caprae* subtypes 'Allgäu', 'Karwendel' and 'Lechtal' which were named according to their geographical appearance \\[[@pone.0181157.ref015],[@pone.0181157.ref016]\\]. ",
"While they showed equal sequences in the remaining RDs by whole genome sequencing different RD4 deletions can be used to identify *M*. *",
"caprae* and its three alpine subtypes by PCR. ",
"Specific primers use the different deletion patterns of the three subtypes to differentiate between them. *",
"M*. *",
"caprae* of the Allgäu subtype contains the whole RD4, the Karwendel subtype a 5kb deletion and the Lechtal subtype a 38kb deletion \\[[@pone.0181157.ref015]\\]. ",
"This is in contradiction to former differentiation models using the complete absence or presence of the RD4 as distinguishing criterion for species identification of *M*. *",
"bovis* and *M*. *",
"caprae*. ",
"This hypothesis was disproved by Domogalla *et al*. ",
"and Rodrigues-Campus *et al*. ",
"\\[[@pone.0181157.ref015],[@pone.0181157.ref017]\\].The aim of this study was to adapt the suitability of ML for detection of MTC from bovine and red deer lymph nodes of naturally infected lymph nodes. ",
"The method ML was compared to the direct-PCR approach, bacterial cultivation and homogenate PCR approach currently used in routine diagnostics of many diagnostic laboratories. ",
"Additionally, ML samples were subtyped by the RD4 method and several ML samples sequenced from methods by whole-genome sequencing without bacterial cultivation.",
"\n\nMaterial and methods {#sec002}\n====================\n\nEthics statement {#sec003}\n----------------\n\nBased on Austrian federal regulations bTB in cattle and red deer is an eradicable disease under mandatory surveillance and monitoring. ",
"Suspicious samples are submitted at the National Reference Laboratory for confirmation of bTB diagnosis by bacteriological culture and PCR. ",
"Analysis of animal specimens was therefore carried out within an official context, meaning that no animals were killed for the purposes of this research project and ethical approval was not necessary.",
"\n\nSample material {#sec004}\n---------------\n\nTwenty five red deer animals delivering 43 samples from different tissue, which were identified as *M*. *",
"caprae* within the ERA-Net EMIDA project \\\"Tb in alpine wildlife\\\" or by different Austrian red deer surveillance programmes were used in this study ([Table 1](#pone.0181157.t001){ref-type=\"table\"}) \\[[@pone.0181157.ref018]\\]. ",
"All 25 red deer animals and one cattle were used for quantification of mycobacteria in native sample material using different methods and compared by results from bacteriology. ",
"Eleven out of these 25 red deer animals (red deer animal 16 to 26) composed a complete sample set of both medial retropharyngeal lymph nodes (pool A), tracheobronchial- mediastinal- and mesenteric lymph nodes (pool B) as also any other suspicious tissue or lymph nodes material with macroscopically visible lesions (pool C). ",
"The sample sets of the other 14 red deer animals (red deer animals 1 to 14) which were hunted for Austrian red deer surveillance programmes and the cattle (cattle 15) which was slaughtered in accordance to the Austrian RinderTbV composed different sample materials with macroscopically visible lesions only ([Table 1](#pone.0181157.t001){ref-type=\"table\"}).",
"\n\n10.1371/journal.pone.0181157.t001\n\n###### Sample material for quantitative analysis.",
"\n\n![](",
"pone.0181157.t001){#pone.0181157.t001g}\n\n ----------------------------------------------------------------------------------------------------------------------\n Sample No. ",
" Host species Sex and Age Sample material Culture\\\n result\n ------------ ----------------------------------------------- ---------------- ----------------------------- ----------\n 1 Red deer stag II 2 Re \\+\n\n 2 Red deer n.d. ",
" Re \\+\n\n 3 Red deer n.d. ",
" Mes,Tra,Lu \\+\n\n 4 Red deer n.d. ",
" Re \\+\n\n 5 Red deer n.d. ",
" Re \\+\n\n 6 Red deer n.d. ",
" Re \\+\n\n 7 Red deer n.d. ",
" 2 Re \\+\n\n 8 Red deer n.d. ",
" 2 Re \\+\n\n 9 Red deer n.d. ",
" Mes \\+\n\n 10 Red deer n.d. ",
" Tra, Med \\+\n\n 11 Red deer n.d. ",
" Re \\+\n\n 12 Red deer n.d. ",
" Re \\+\n\n 13 Red deer hind Par, Li, Man, Re, Tra, Med, \\+\n\n 14 Red deer hind Re \\+\n\n 15 Cattle female,13years Med, Lu \\+\n\n 16 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} stag II A and B unknown\n\n 17 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} stag II A, B, C(Re) unknown\n\n 18 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} hind \\> 2y A, B, C(Re) unknown\n\n 19 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} stag II A, B, C(Lu, Tra) unknown\n\n 20 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} stag II A, B, C(Par) unknown\n\n 21 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} stag II A, B unknown\n\n 22 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} stag III A, B unknown\n\n 23 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} hind \\> 2y A, B, C(Med, Tra) unknown\n\n 24 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} stag II A, B unknown\n\n 25 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} stag I A, B, C(Re) unknown\n\n 26 Red deer[\\*](#t001fn002){ref-type=\"table-fn\"} stag III A, B unknown\n ----------------------------------------------------------------------------------------------------------------------\n\nRe, one medial retropharyngeal lymph node; 2Re, both medial retropharyngeal lymph nodes; Mes, mesenteric lymph node; Med, mediastinal lymph node; Tra, tracheobronchial lymph node; Lu, lung tissue; Li, liver lymph node; Man, mandibularis lymph node; Par, parotid lymph node\n\n\\*, free ranging red deer animals hunted within the EMIDA ERA-Net project; A, pool A containing both medial retropharyngeal lymph nodes; B, pool B containing TraMedMes;C, pool C is determined; stag III, male between 1 and 4 years; stag II, male between 5 and 9 years; stag I, male older than 9 years; hind \\> 2y, female older than 2 years; hind \\< 2y, female younger than 2 years; n.d., ",
"not defined\n\nSample material containing macroscopically visible lesions from additional 12 *M*. *",
"caprae* confirmed red deer animals hunted for Austrian red deer surveillance programmes (red deer animal 27 to 38) and five *M*. *",
"caprae* confirmed cattle slaughtered in accordance to the national legislation RinderTbV 2008;current status (cattle 39 to 44) were used for ML RD4 subtyping and three for whole genome sequencing by the Illumina sequencing technique.",
"\n\n### Sample preparation and quantitative PCR ([Fig 1](#pone.0181157.g001){ref-type=\"fig\"}) {#sec005}\n\nEnrichment of bacteria was performed by ML which proceeds in three steps: 1. ",
"the homogenization of the tissue material; 2. ",
"the chemical lysis of the matrix (tissue) and; a washing step (3.) ",
"of the pelleted bacteria was necessary to remove any left lysis buffer. ",
"The resulting pellet was dissolved in ATL buffer of the DNA extraction kit. ",
"The homogenate qPCR method used the same starting material. ",
"Therefore an aliquot of step 1 of ML was taken away after homogenization. ",
"Precipitation of solid material was performed by centrifugation and the resulting pellet is dissolved in ATL buffer of the same DNA extraction kit. ",
"Direct qPCR is the only method which directly used the tissue material. ",
"Therefore a very small piece of tissue was taken up in Lysis buffer of another DNA extraction kit. ",
"Due to the robust and complex structure of the mycobacteria wall, a mechanical disruption, called bead beating, was performed for all three methods in order to release any nucleic acid from the mycobacteria. ",
"QPCR of all samples was performed by the same qPCR kit.",
"\n\n{#pone.0181157.g001}\n\nDNA extraction for direct qPCR {#sec006}\n------------------------------\n\n25 milligrams (mg) of suspicious lesions or visible lesion containing sample material was cut out with a scalpel from the tissue or lymph nodes and suspended in 200 μl Tissue Lysis Buffer of the High Pure PCR Template Preparation kit from Roche, Rotkreutz, Switzerland. ",
"Bead beating was performed by transferring the lysis material into a 2 ml safe lock centrifugation tube (Eppendorf, Hamburg, Germany) containing a 5 mm stainless steel bead (Qiagen, Hilden, Germany). ",
"For mechanical burst of the mycobacterial cell wall, the tube was shaken 2 times for 3 min at 30 Hertz (Hz) using the Mixer Mill 301 (Retsch, Haan, Germany). ",
"The obtained suspension was used for proper DNA extraction as recommended by the manufacturer of the High Pure DNA Template Preparation kit.",
"\n\nMatrixlysis (ML) {#sec007}\n----------------\n\nFor bacterial recovery up to ten grams (g) of frozen tissue material was homogenized in five millilitre (ml) Solution A (0.25 M Sucrose, 1 mM EDTA, 0.05 M Tris pH 7.6; 0.1% (w/v) Savinase GTT24) using the ULTRA-TURRAX® Tube Drive Workstation (IKA^®^, Staufen, Germany). ",
"Tissue material which was too large to fit into the DT-20 Tube (IKA^®^, Staufen, Germany) was cut with a scalpel and treated equally. ",
"If necessary, 5 ml aliquots were pooled in a 50 ml screw cap tube (50ml SuperClear^TM^ Centrifuge Tube with plug style cap, VWR, Radnor, USA). ",
"The homogenized material containing 5, 10 or 15 ml was filled up to 50 ml with phosphate buffered saline (PBS), incubated for 30 min at 37°C in a shaking water bath (1003, GFL, Burgwedel, Germany) and centrifuged for 30 min at 3220 x g (Rotina 420, Hettich, Tuttlingen, Germany). ",
"The supernatant was discarded and the pellet was resuspended in 45 ml Lysis Buffer (8 M Urea, 1% (v/v) SDS, 1 x PBS). ",
"After incubating for 30 min at 37°C in a shaking water bath and centrifugation for 30 min at 3220 x g, the supernatant was discarded and the pellet was resuspended in 40 ml Washing Buffer (1 x PBS, 0.35% (v/v) Lutensol AO-7). ",
"Again, the samples were incubated for 30 min at 37°C in a shaking water bath, centrifuged for 30 min at 3220 x g and the supernatant was discarded. ",
"The pellet was resuspended in 1 ml PBS, transferred into a 2 ml reaction tube (Eppendorf, Hamburg, Germany) and centrifuged for 5 min at 8000 x g (5415R, Eppendorf, Hamburg, Germany). ",
"This final washing step was repeated once.",
"\n\nDNA extraction for ML qPCR and homogenate qPCR {#sec008}\n----------------------------------------------\n\nFor ML qPCR the bacteria pellet resulting from ML was resuspended in 180 μl Lysis Buffer ATL of the kit DNeasy^®^Blood&Tissue Kit from Qiagen, Hilden, Germany. ",
"For the homogenate qPCR, 1 ml of homogenized sample material ([Fig 1](#pone.0181157.g001){ref-type=\"fig\"}) was centrifuged for 25 min at 16000 x g; the supernatant discarded and the pellet resuspended in 180 μl Lysis Buffer ATL of the DNeasy^®^Blood&Tissue Kit. ",
"To perform bead beating, the lysed sample material was transferred into a 2 ml safe lock centrifugation tube (Eppendorf) containing a 5 mm stainless steel bead (Qiagen). ",
"For mechanical burst of the mycobacterial cell wall the lysis material was treated as described by direct qPCR using the Mixer Mill 301. ",
"The obtained suspension was used for proper DNA extraction as recommended by the manufacturer of the DNeasy^®^Blood&Tissue kit.",
"\n\nDNA extraction for RD4 subtyping and whole genome sequencing {#sec009}\n------------------------------------------------------------\n\nFor RD4 subtyping and whole genome sequencing the matrixlysis pellet was suspended in corresponding cell suspension solution of the Gentra Puregene Yeast/Bact. ",
"Kit (Qiagen, Hilden, Germany) and DNA extraction performed as described.",
"\n\nQPCR (quantitative PCR) or real-time PCR {#sec010}\n----------------------------------------\n\nQPCRs were performed with the artus^®^ M. tuberculosis TM qPCR Kit (Qiagen/Deutschland), according to the manufacturers protocol. ",
"Detection was performed on the 7500 Fast Real-Time PCR System (Applied Biosystems, Waltham, USA).",
"\n\nArtificial inoculation of bovine lymph nodes {#sec011}\n--------------------------------------------\n\nIn order to evaluate the applicability of ML for MTC detection, artificial contamination experiments with bovine lymph nodes were performed. ",
"For these experiments, five PCR negatively-tested bovine lymph nodes (5g each) were spiked with 100μl of a *Mycobacterium bovis Bacillus Calmette-Guérin* (BCG). ",
"Therefore, the *M*. *",
"bovis BCG* was grown in Middlebrook 7H9 liquid media containing Tween 80 (0.05%) for three to four weeks. ",
"The spiked lymph nodes were processed with ML and subsequently subjected to DNA-extraction and qPCR, while the original five *M*. *",
"bovis BCG* inocula aliquots were directly subjected to DNA-extraction and qPCR without extra processing.",
"\n\nPathoscoring of naturally infected samples {#sec012}\n------------------------------------------\n\nA bTB lesion score (pathoscore) was defined for lymph nodes and lung tissue in accordance to Ballesteros et *al*. ",
"\\[[@pone.0181157.ref019]\\]. ",
"It considers the distribution and the intensity of the lesions. ",
"Lesions of a size less than 1 cm are classified as \\\"A\\\" lesions and lesions exceeding 1 cm as \\\"B\\\" lesions. ",
"Summarizing, pathoscore 0 always determines a NVL sample; samples of pathoscore 1 and 2 only contain type \\\"A\\\" lesions and samples of pathoscore 3 or higher contain lesions of type \"B\".",
"\n\nBacteriology ([Fig 1](#pone.0181157.g001){ref-type=\"fig\"}) {#sec013}\n----------------------------------------------------------\n\nFor bacteriological cultivation, two to three grams of pathologically suspicious tissue material was homogenized in five ml NaCl solution (0.9%) using the IKA Ultra-Turaxx^®^ Tube Drive Workstation (IKA^®^, Staufen, Germany). ",
"The suspension was decontaminated with 1% N-Acetyl-L-Cystein-NaOH solution and neutralized with 20 ml phosphate buffer (pH 6.8) as recommended by the World Organization for Animal Health (OIE) (2012) Manual \\[[@pone.0181157.ref020]\\]. ",
"The solution was centrifuged for 20 min at 3300 x g and the suspension discarded. ",
"The suspension pellet was plated on two growth media---Lowenstein-Jensen with Glycerin and PACT (polymyxin B, amphotericin B, carbenicillin and trimethoprim) and Stonebrink with PACT (both purchased from Heipha) using swabs. ",
"Incubation was performed at 37°C for 12 weeks and bacterial growth was frequently screened. *",
"M*. *",
"caprae* species identification was performed by reversed line blotting (Geno Type® MTBC, HAIN Life Science, Germany).",
"\n\n### Sample preparation RD4 subtyping and next generation sequencing ([Fig 1](#pone.0181157.g001){ref-type=\"fig\"}) {#sec014}\n\nFor RD4 subtyping and whole genome sequencing DNA extraction was performed using the GentraPuregene Yeast/Bact. ",
"Kit as described by Broeckl *et al*. ",
"\\[[@pone.0181157.ref021]\\]. ",
"Bacterial colonies were scraped off the solid Loewenstein-Jensen or Stonebrink solid growth media and suspended and washed in 1 ml PBS by vortexing. ",
"After centrifugation for 6 min at 15000 x g (5415R, Eppendorf, Hamburg, Germany) the samples were resuspended in 600 μl Cell Suspension Solution. ",
"Cell pellets resulting from ML were directly suspended in 600 μl Cell Suspension Solution. ",
"Three μl Lytic Enzyme were added and the samples were inverted for 25 times in a 1.5 ml centrifugation tube (Eppendorf, Hamburg, Germany). ",
"After incubation for 30 min at 37°C and centrifugation for 6 min at 15000 x g the supernatant was discarded and the pellet was resuspended in 450 μl Cell Lysis Solution and 15 μl Proteinase K. Lysis was performed at 57°C and 600 rpm on a shaking Thermocycler (Thermomixer Comfort, Eppendorf, Hamburg, Germany) overnight. ",
"To stop proteolytic proteinase K activity, the samples were incubated on ice for 1 min, 160 μl Protein Precipitation Solution were added and the samples were mixed for 20 seconds using a vortex. ",
"After centrifugation for 6 min at 15000 x g, the supernatant was transferred into a new 1.5 ml reaction tube (Eppendorf, Hamburg, Germany) containing 600 μl Isopropyl alcohol (100%) and 1.2 μl Glycogen. ",
"The samples were mixed gently by inverting 50 times and centrifuged for 15 min at 15000 x g. The supernatant was discarded and the pellet was resuspended and washed in 700 μl Ethanol (70%(v/v)). ",
"The samples were centrifuged for 10 min at 14000 x g and air dried for up to 10 min. ",
"The dry pellet was resuspended in 100 μl DNA Hydration Solution and incubated at 65°C for one hour.",
"\n\nRD4 subtyping {#sec015}\n-------------\n\nRD4 Subtyping was performed as developed and described by Domogalla *et al*. ",
"and Rettinger *et al*. ",
"with adaptions as following: All reactions were carried out as simplex in a total volume of 25 μl, each reaction contained 0.625 U of HotStarTaq® DNA Polymerase (Qiagen, Hilden, Germany), 0.5 μM Primer (for detailed Primer sequences see Domogalla *et al*.), ",
"primers flanking the 38kb deletion annealed at 60°C. ",
"After PCR amplification, the PCR products were separated by gel electrophoresis in 1% agarose gels in Tris-borate EDTA (1 x TBE) buffer at 120V for 40 min and visualized using PeqGreen from Peqlab (5μl/100ml agarose gel).",
"\n\nNext generation sequencing {#sec016}\n--------------------------\n\nSequencing libraries were constructed from the DNA of three samples that were subjected to the Matrix Lysis. ",
"Each sample with 325 ng of DNA was fragmented by sonication with a M220 Ultrasonicator (Covaris, MA, USA) to a medium length of 250 bp. ",
"Fragmented DNA were then used to construct sequencing libraries with the single-stranded Next generation sequencing (NGS) Library Preparation Kit (Swift Bioscience, Ann Arbor, USA) according to the manufacturer\\`s instructions and Dual Indexing was performed with the length of 8 basepairs barcodes each. ",
"Finally, the Next Generation Sequencing was done on an Illumina HiSeq 1500 (Illumina, San Diego, USA) sequencer in a paired-end mode with a read length of 100 bp in each direction. ",
"Raw sequencing data from the sequencer was obtained as FASTQ format. ",
"In order to reassign the reads to their sample origin, raw data were de-multiplexed based on their respective dual barcodes with the Je\\'s Illumina-illu \\[[@pone.0181157.ref022]\\] tool. ",
"Only those reads that fulfil strict quality criteria for both index reads are selected for further analyses. ",
"These criteria are a complete index sequence without mismatch and a miminum quality of Q30. ",
"The resultant reads were mapped against the assembly of both *M*. *",
"caprae* \\[[@pone.0181157.ref021]\\] and *Bos taurus (UMD3*.*1*.*1)* using the BWA mem \\[[@pone.0181157.ref023]\\]. ",
"Percentage of duplicated reads and summary of the mapping statistics was then estimated using samtool\\'s rmdup \\[[@pone.0181157.ref024]\\] and flagstat \\[[@pone.0181157.ref024]\\] module respectively.",
"\n\nResults {#sec017}\n=======\n\nArtificial inoculation of bovine lymph nodes {#sec018}\n--------------------------------------------\n\nThe results of this evaluation of ML applicability showed that *M*. *",
"bovis Bacillus Calmette-Guérin* was reproducibly recovered from 5g lymph node matrix with an efficiency of 24%. ",
"The average ct-value was 25.7 for the spiked lymph nodes and 23.4 for the *M*. *",
"bovis Bacillus Calmette-Guérin* culture. ",
"These results are in good agreement to the efficiencies obtained by Mayrl *et al*. ",
"\\[[@pone.0181157.ref004]\\] and demonstrate the applicability of the ML for lymph node tissue. [",
"Table 2](#pone.0181157.t002){ref-type=\"table\"} shows the results of 5 x 5g bovine lymph node tissue, spiked with Mycobacterium bovis BCG and ML processed. ",
"Ct-values were compared with the untreated BCG inoculum.",
"\n\n10.1371/journal.pone.0181157.t002\n\n###### qPCR results of artificially spiked lymph nodes.",
"\n\n![](",
"pone.0181157.t002){#pone.0181157.t002g}\n\n Replicate Nr. ",
" Control (Ct) Ct after Matrixlysis\n ------------------------------------------ -------------- ----------------------\n I 23.8 24.9\n II 24.1 26.9\n III 23.3 25.9\n IV 21.9 24.7\n V 23.5 25.9\n Avg 23.4 25.7\n RSD[\\*](#t002fn001){ref-type=\"table-fn\"} 0.86 0.90\n Recovery 24%\n\n\\* Relative standard deviation (RSD)\n\nML qPCR in comparison to bacterial culture, direct qPCR and homogenate qPCR {#sec019}\n---------------------------------------------------------------------------\n\nAs primary step in quantifying naturally infected tissue material, bacterial culture positive samples of animals 1 to 15 ([Table 1](#pone.0181157.t001){ref-type=\"table\"}) were used to test if ML is capable for subsequent DNA extraction and qPCR and to determine the sensitivity of ML qPCR in comparison to bacteriology, the \\\"gold standard\\\" in Tb diagnostic. ",
"Therefore, the samples were analysed by direct qPCR, homogenate qPCR, and ML qPCR and compared to the positive results from bacteriology. ",
"For ML qPCR, a ct-value was obtained for all 15 samples and therefore the sensitivity was determined as least as high as for bacteriology. ",
"Both methods, direct qPCR and the homogenate qPCR, detected MTC in 13 of 15 positive animals and were therefore less sensitive than ML and the bacterial culture ([Table 3](#pone.0181157.t003){ref-type=\"table\"}, [Fig 2](#pone.0181157.g002){ref-type=\"fig\"}). ",
"When comparing the ct-values of the different methods, ML qPCR showed in 12 cases the lowest ct-value and therefore the highest sensitivity of all quantitative methods ([Table 3](#pone.0181157.t003){ref-type=\"table\"}). ",
"Only red deer sample 1 and 9 showed a lower ct-value by direct qPCR indicating that in these two cases the 25 mg contained the optimal \\\"lesion-containing\\\" material ([Table 3](#pone.0181157.t003){ref-type=\"table\"}). ",
"Regardless of these two cases, the differences in the ct-values between ML qPCR and direct qPCR varied from 0.5 to 8.6 ct-values. ",
"The average delta ct-value was 3.13 lower than for direct qPCR (not indicated). ",
"The differences in the ct-values between ML qPCR and the homogenate qPCR varied also from -1.0 to 6.4 which was unexpected as the starting material for both methods was the same and one would expect a constant relation between the ct-values of both methods. ",
"One explanation might be that mycobacteria are not evenly diluted in the homogenized tissue solutions because they form lumps. ",
"This might also explain why the ct-value of the homogenate qPCR of red deer animal 7 was one ct-value lower than for the ML qPCR. ",
"In this case the 1 ml aliquot of the homogenized sample material used for the homogenate qPCR method \\\"accidentally\\\" contained a lump of mycobacteria counting twice of the amount than used for ML (delta ct 1).",
"\n\n{#pone.0181157.g002}\n\n10.1371/journal.pone.0181157.t003\n\n###### ML qPCR was compared to direct qPCR, homogenate qPCR and bacteriology.",
"\n\n![](",
"pone.0181157.t003){#pone.0181157.t003g}\n\n Samp. ",
"No. ",
" Host species Lymph node/ tissue Culture qPCR results (Ct) weight of lymph node for ML \\[g\\] Pathoscore \n ------------------------- -------------- ----------------------------- --------- ------------------- ----------------------------------- ------------ ----- ---------------------------------------------\n 1 Red deer 2 Re \\+ 38,5 41,5 40,2 4,2 3\n 2 Red deer Re \\+ 26,4 25,5 22,3 2,4 3\n 3 Red deer Mes,Tra,Lu \\+ no ct 33,9 31,2 2,7 3\n 4 Red deer Re \\+ no ct no ct 36,0 1,3 1\n 5 Red deer Re \\+ 36,4 30,6 27,8 2,7 3\n 6 Red deer Re \\+ 32,2 32,5 29,1 2,4 3\n 7 Red deer 2 Re \\+ 36,4 35,4 36,4 2,3 2\n 8 Red deer 2 Re \\+ 32,7 32,2 29,4 2,2 3\n 9 Red deer Mes \\+ 28,4 37,0 33,1 1,0 3\n 10 Red deer Tra, Med \\+ 27,1 28,4 24,6 2,3 3\n 11 Red deer Re \\+ 40,0 no ct 34,1 2,5 2\n 12 Red deer Re \\+ 37,0 41,9 35,6 2,3 2 or 3[\\*](#t003fn002){ref-type=\"table-fn\"}\n 13 Red deer Par, Li, Man, Re, Tra, Med, \\+ 35,8 36,3 34,5 5,0 3\n 14 Red deer Re \\+ 34,0 37,4 33,5 2,1 1\n 15 Cattle Med, Lu \\+ 32,3 33,9 28,6 4,1 2\n No. ",
"of positive animals 15 / 15 13 / 15 13 / 15 15 / 15 \n\nRe, one medial retropharyngeal lymph node; Mes, mesenteric lymph node; Med, mediastinal lymph node; Tra, tracheobronchial lymph node; Lu, lung tissue; Li, liver lymph node; Man, mandibularis lymph node; Par, parotid lymph node; 2Re, both medial retropharyngeal lymph nodes; ML, Matrixlysis\n\n\\* a more precise pathoscore determination not possible\n\nAfter this pre-test with only culture-positive sample material, 28 samples of 11 red deer animals (red deer animal 16 to 26, [Table 1](#pone.0181157.t001){ref-type=\"table\"}) from the ERA-Net Project were examined ([Table 4](#pone.0181157.t004){ref-type=\"table\"}, [Fig 2](#pone.0181157.g002){ref-type=\"fig\"}). ",
"These red deer animals comprised a whole sample set, which was already predefined: pool A contained both retropharyngeal lymph nodes, pool B the tracheobronchial-, mediastinal- and mesenterial lymph nodes and in cases of red deer animals 17, 18, 19, 20, 23 and 25 any further visible lesion containing tissue material as indicated in sample pool C ([Table 4](#pone.0181157.t004){ref-type=\"table\"}). ",
"Not all red deer animals were confirmed positive by bacteriology.",
"\n\n10.1371/journal.pone.0181157.t004\n\n###### ML qPCR of 28 sample materials from 11 red deer animals compared to direct qPCR, homogenate qPCR and bacteriology.",
"\n\n![](",
"pone.0181157.t004){#pone.0181157.t004g}\n\n ---------------------------------------------------------------------------------------------------------------------------------------------------------------\n Samp. ",
"No. ",
" Host species Lymph node/tissue Culture qPCR results (Ct) weight of lymph node for ML \\[g\\] Pathoscore \n ----------------------------- -------------- ------------------- ----------- ------------------- ----------------------------------- ------------ --------- ---\n 16 Red deer \\- A \\+ 33,8 38,0 37,6 2,3 4\n\n \\- B \\+ 34,1 33,0 30,5 2,2 4 \n\n 17 Red deer \\- A \\- no ct no ct no ct 5,0 0\n\n \\- B \\- no ct no ct no ct 3,1 0 \n\n \\- C(Re) \\- no ct 39,1 35,1 2,0 1 \n\n 18 Red deer \\- A \\- no ct no ct no ct 4,9 0\n\n \\- B \\- no ct no ct no ct 2,9 0 \n\n \\- C(Re) \\+ no ct 33,2 28,9 5,7 2 \n\n 19 Red deer \\- A \\- no ct no ct no ct 6,7 0\n\n \\- B \\- no ct no ct no ct 2,0 0 \n\n \\- C(Lu &Tra) \\+ 32,2 35,3 29,4 5,5 3,4 \n\n 20 Red deer \\- A \\- no ct no ct 29,5/33,8 2,6/7,2 0\n\n \\- B \\- no ct no ct 36,1 3,4 0 \n\n \\- C(Par) \\+ 34,2 38,4/36,5 38,2/34,9 2,2/6,3 3 \n\n 21 Red deer \\- A \\+ no ct 36,3 37,6 2,8 1\n\n \\- B \\+ no ct no ct no ct 4,4 0 \n\n 22 Red deer \\- A \\+ 25,4 36,7 30,1 2,2 3\n\n \\- B \\- 36,0 29,8 22,6 8,5 0 \n\n 23 Red deer \\- A \\- no ct no ct 37,0 2,9 0\n\n \\- B \\- no ct no ct no ct 2,1 0 \n\n \\- C(Med,Tra) \\+ 36,4 no ct 32,0 2,4 3,1 \n\n 24 Red deer \\- A \\+ 40,0 no ct 35,2 10,0 3\n\n \\- B \\- no ct no ct 39,2 1,5 0 \n\n 25 Red deer \\- A \\+ no ct no ct 44,4 2,3 1\n\n \\- B \\- no ct 39,6 35,1 4,9 0 \n\n \\- C(Re) \\+ 33,2 34,5/35,2 32,7/27,5 2,0/4,0 3 \n\n 26 Red deer \\- A \\+ 36,0 36,4 31,5 3,6 3\n\n \\- B \\- no ct no ct 32,8 3,2 0 \n\n No. ",
"of positive lymph nodes 13 / 28 10 / 28\\ 12 / 28\\ 20 / 28 \n\n No. ",
"of positive animals 10 / 11 8 / 11 9 / 11 11 / 11 \n ---------------------------------------------------------------------------------------------------------------------------------------------------------------\n\nRe, one medial retropharyngeal lymph node; Mes, mesenteric lymph node; Med, mediastinal lymph node; Tra, tracheobronchial lymph node; Lu, lung tissue; Li, liver lymph node; Man, mandibularis lymph node; Par, parotid lymph node; A, pool A containing both medial retropharyngeal lymph nodes; B, pool B containing TraMedMes; ML, Matrixlysis;\n\nRed deer animal 16 had a pathoscore of 4 in all investigated samples of this animal. ",
"It showed an open tuberculosis in the lung which was not examined in this study. ",
"Both sample pools of this animal were tested positive in all methods ([Fig 2](#pone.0181157.g002){ref-type=\"fig\"}).",
"\n\nRed deer animal 17 only showed a pathoscore in pool C (sample 17 C) and a pathoscore of 0 in samples A and B. The observed pathoscore 1 corresponded to a single lesion of 2 mm in one of the two medial retropharyngeal lymph nodes. ",
"While samples A and B were negative in all tests, sample C was only positive by ML and the homogenate method, both resulting from the same starting material. ",
"This was the only tested animal which was culture negative in all samples and therefore would have been detected negative by routine diagnostic methods.",
"\n\nRed deer animal 18 showed similar results as red deer animal 17 with the difference that sample C was also positive by bacteriology and an occurrence of several milliar lesions in one medial retropharyngeal lymph node.",
"\n\nRed deer animal 19 presenting several \\\"B\\\" lesions of more than 2 cm in the tracheobronchial lymph node and in the lung, was only positive in sample pool C; containing both tissue samples of pathoscore 3 and 4, respectively. (",
"In a very first test this animal was also positive in sample A, B and C by bacteriology.)",
"\n\nIf comparing the ct-values of samples 17, 18 and 19 C, the detected ct-values of ML were always 4 to 5.9 ct-values lower than the ct-values of the homogenate method, which correspond a 16 to 60-fold higher sensitivity. ",
"Even the difference to the direct qPCR of sample 19C was remarkable. ",
"Nevertheless, pathoscore 0 samples of these three red deer animals were not detected by any other method than by ML.",
"\n\nRed deer animal 21 showed a single lesion of type \"A\" in the retropharyngeal lymph node. ",
"Bacteriology detected the lesions as well as NVL in sample B, while ML qPCR detected only the lesion containing sample material of the retropharyngeal lymph node. ",
"Direct qPCR was negative in both sample pools. ",
"The explanation for the negative ML qPCR might be an exhaust of sample material.",
"\n\nVice versa red deer animal 22 showed a pathoscore of 3 and 0 in sample A and B, respectively ([Fig 2](#pone.0181157.g002){ref-type=\"fig\"}). ",
"While sample A was detected by all methods, sample B with a pathoscore of 0 was only negative by bacteriology but positive by all other methods. ",
"The lowest ct-value of 25.4 of sample A was observed by direct qPCR due to its easy detection of a well-developed \"B\" lesion. ",
"As ML qPCR was performed from exhausting sample material, after material withdrawal for direct qPCR and bacteriology, the ct-value of ML qPCR, containing mainly lesions surrounding tissue, was higher than for direct qPCR. ",
"This was also observed for sample 1 and 9 of the pre-test. ",
"But in all these cases, the pathoscores were higher than 2. ",
"One or a few milliar lesions characterized as pathoscores 1 and 2 were always negative by direct qPCR (samples 17C, 18C, 21A and sample 4 of the pre-test). ",
"Only red deer sample 7 of the pre-test showed identical ct-values by both methods.",
"\n\nSome pathoscore 0 samples of red deer animals 20, 23, 24 and 26 were detected only by ML qPCR but no other methods indicating that ML qPCR is able to detect NVL samples. ",
"Only sample 25B was additionally positive by the homogenate method but with a much higher ct-value. ",
"NVL samples detected only by ML were samples 20A, 20B, 23A, 24B, 25B and 26B. As visible lesions were observed in other parts of the animals, these animals or samples cannot be classified as false positives.",
"\n\nAs red deer animals 17 and 18, red deer animal 25 showed patho-morphologically visible lesions only in the one of the two medial retropharyngeal lymph nodes, but lesions of animals 23 and 25 were further developed and could be classified as \\\"B\\\" lesions. ",
"To avoid a dilution of the sample material A or B obligatory containing both medial retropharyngeal lymph nodes or the mediastinal- and tracheobronchial lymph nodes, respectively, material-containing lesions of these animals were cut out and treated separately as sample C. While red deer animals 17 and 18 were only positive by sample C (lesions containing material), ML qPCR additionally detected NVLs in sample A of animal 23 and sample B of animal 25.",
"\n\nThe maximum amount of 10 g sample material was used in case of sample A of red deer animal 24. ",
"ML qPCR showed a ct-value of 35.2, direct qPCR a ct-value of 40 and the homogenate method no ct-value indicating that most of the lesion containing material of pathoscore 3 was exhausted and used for bacteriology which had to be repeated due to technical issues. ",
"To test, if more starting material always results in a lower ML qPCR ct-value, we performed ML of two different amounts of sample material in case of samples 20A, 20C and 25C. The hypothesis could be confirmed in case of sample 20C and 25C ([Fig 2](#pone.0181157.g002){ref-type=\"fig\"}). ",
"The higher amounts of 6.3 g and 4.0 g compared to 2.2 g and 2.0 g, respectively, resulted in 3.3 and 4.5 lower ct-values. ",
"Our hypothesis could not be confirmed in the case for sample 20A where 7.2g sample material resulted in a higher ct-value than 2.6 g indicating an exhaust of sample material after many test repeats. ",
"In total, we were able to detect MTC in 35 out of 43 lymph nodes by ML qPCR which corresponds to 26 out of 26 positively \\\"selected\\\" animals. ",
"The detected lymph nodes also include six NVL lymph nodes. ",
"In comparison, bacteriology detected 28 out of 43 lymph nodes, which corresponds to 25 out of 26 positive animals. ",
"While bacteriology detected only one NVL sample (sample B of red deer animal 21), it did not detect sample C of red deer animal 17 and sample B of red deer animal 22, both classified as pathoscore 1 samples indicating that even the \\\"gold standard\\\" in TB diagnostic would have detected one red deer animal false negative. ",
"Direct qPCR detected 23 out of 43 lymph nodes corresponding to 21 out of 26 positive animals and the homogenate qPCR 25 out of 43 lymph nodes or 22 out of 26 positive animals. ",
"If these samples would have been tested in accordance to the national legislation RinderTbV 2008 in the current status, which says that only direct qPCR positive samples are further investigated by bacteriology in order to confirm the PCR positive result, five animals would have been diagnosed false negative by direct qPCR and four by the homogenate qPCR ([Table 3A and 3B](#pone.0181157.t003){ref-type=\"table\"}).",
"\n\nA correlation between ct-values and pathoscore group 1&2 (type \"A\" lesions\") and group 3&4 (type \"B\" lesions) is shown in [Table 5](#pone.0181157.t005){ref-type=\"table\"} and [Fig 3](#pone.0181157.g003){ref-type=\"fig\"}.",
"\n\n{#pone.0181157.g003}\n\n10.1371/journal.pone.0181157.t005\n\n###### Correlation between pathoscores and ct-values.",
"\n\n![](",
"pone.0181157.t005){#pone.0181157.t005g}\n\n -------------------------------------------------------------------------------------------------\n Method pathoscore 1 & 2\\ Pathoscore 1 & 2\\ pathoscore 3 & 4\\ pathoscore 3 & 4\\\n average ct-value RSD average ct-value RSD\n ----------------- ------------------- ------------------- ------------------- -------------------\n direct qPCR 40.3 5.4 33.1 5.5\n\n homogenate qPCR 38.2 4.6 33.7 4.0\n\n ML qPCR 33.8 3.4 30.3 4.4\n -------------------------------------------------------------------------------------------------\n\nRSD, relative standard deviation\n\nFor pathoscore group 1 & 2 the average ct-value of ML is 4.4 ct-values lower than the average ct-value of the homogenate qPCR and 6.5 ct- values lower than the average ct-value of the direct qPCR. ",
"For pathoscore group 3 & 4 the average ct-value of ML is 30.3 and therefore only about 3 ct-values lower than the remaining two qPCR methods, indicating an easier detection of well-developed lesions by direct and homogenate qPCR.",
"\n\nBacterial cultivation of ML derived bacteria (Viability test of ML) {#sec020}\n-------------------------------------------------------------------\n\nTo test, if the mycobacteria are still viable after ML, all samples of red deer animals and the cattle which derived from ML were grown on Loewenstein-Jensen and Stonebrink solid media; both containing PACT. ",
"After an incubation time of 12 weeks at 37°C, none of the 43 samples showed growth on either of the both media. ",
"On one hand this is a good result regarding the biosafety aspects, because due to very high bacterial loads there is no infection potential after the lysis step of ML. ",
"On the other hand without amplification of the pathogen, the lesion containing is limited and becomes more and more exhausted after every additional assay.",
"\n\nMatrixlysis subtyping {#sec021}\n---------------------\n\nAs qPCR can only give information if the pathogen is a member of the Mycobacterium tuberculosis complex (MTC), species identification and *M*. *",
"caprae* subtyping or genotyping is used to be performed from bacterial culture isolates. ",
"Instead of *MIRU*-VNTR genotyping which are culture dependent, complex and extensive \\[[@pone.0181157.ref025],[@pone.0181157.ref026]\\] we performed RD4 subtyping of our ML samples. ",
"In a previous study, whole genome data demonstrated that three *M*. *",
"caprae* subtypes, 'Allgäu', 'Lechtal' and 'Karwendel' were characterized by genomic variations in the RD4. ",
"The three typical deletion patterns could be identified by PCR using bacterial culture ([Fig 4](#pone.0181157.g004){ref-type=\"fig\"}) \\[[@pone.0181157.ref015],[@pone.0181157.ref016]\\].",
"\n\n{#pone.0181157.g004}\n\nTo test, if RD4 subtyping can be performed from ML resulting bacteria, we extracted the DNA of 12 red deer and six cattle ML derived bacteria pellets and performed RD4 subtyping. ",
"As 17 of 18 animals were confirmed by bacterial cultivation, RD4 subtyping was also performed from these 17 bacterial isolates and compared with results from ML subtyping. ",
"In order to test the DNA quality, all samples were tested by qPCR ([Table 6](#pone.0181157.t006){ref-type=\"table\"}). ",
"QPCR ct-values and the intensities of DNA bands on agarose gels of RD4 subtyping were well comparable. ",
"DNA concentration measurements performed with a Nanodrop did not accompany with the previous results. ",
"The reason for the different DNA concentration measurements could be the high amounts of host DNA in the samples. ",
"Apart from red deer samples 36, 38 and the cattle samples 41A, 43 and 44 all ML samples could be assigned to a subtype. ",
"ML samples 27 to 35, 37, 40, 41and 42 were identified as Lechtal subtypes ([Fig 5](#pone.0181157.g005){ref-type=\"fig\"} and [S1 File](#pone.0181157.s001){ref-type=\"supplementary-material\"}).",
"\n\n{#pone.0181157.g005}\n\n10.1371/journal.pone.0181157.t006\n\n###### RD4 Subtyping of ML samples.",
"\n\n![](",
"pone.0181157.t006){#pone.0181157.t006g}\n\n Sample No. ",
" Host species Lymph node/tissue weight of lymph node for ML \\[g\\] Pathoscore RD4 Subtype (Result qPCR) \n ------------ -------------- ------------------- ----------------------------------- ------------- --------------------------- ----------------\n 27 Red Deer Head 5.2 4 Lechtal (+) Lechtal (+)\n 28 Red Deer Head 6.5 3 Lechtal (+) Lechtal (+)\n 29 Red Deer Head 8.3 3 Lechtal (+) Lechtal (+)\n 30 Red Deer Head 6.7 3 Lechtal (+) Lechtal (+)\n 31 Red Deer Head 8.1 1 Lechtal (+) no subtype (+)\n 32 Red Deer Lung 3.7 5 (open Tb) Lechtal (+) Lechtal (+)\n 33 Red Deer Lung 5.0 3 Lechtal (+) Lechtal (+)\n 34 Red Deer Lung 6.1 3 Lechtal (+) Lechtal (+)\n 35 Red Deer Lung 4.2 1 Lechtal (+) Lechtal (+)\n 36 Red Deer Lung 6.0 3 no subtype (+) Lechtal (+)\n 37 Red Deer Head 7.4 2 or 3 Lechtal (+) culture neg\n 38 Red Deer Re 3.9 3 no subtype (+) Karwendel (+)\n 40 Cattle Head 4.3 2 or 3 Lechtal (+) Lechtal (+)\n 41 Cattle Udder 4.8 2 no subtype (-) Lechtal (+)\n Retro 4.2 2 Lechtal (+) Lechtal (+) \n 42 Cattle TrachMed 2.9 2 Lechtal (+) Lechtal (+)\n 43 Cattle Mediastinal 4.3 2 no subtype (+) Lechtal (+)\n 44 Cattle Lung 3.3 5 (open Tb) no subtype (+) Allgäu (+)\n\n(+) qPCR positive; (-) qPCR negative; Re, one medial retropharyngeal lymph node; TrachMed, Tracheobronchial and Mediastinal lymph node; ML, Matrixlysis\n\nBacterial culture isolates from sample 31 did not show any subtype although qPCR showed a ct-value and the ML sample identified subtype Lechtal. ",
"ML samples 36 and 43 could not be subtypes although qPCR was positive and the bacterial culture isolates determined the Lechtal subtype. ",
"During the DNA extraction of these ML samples the protein precipitation did not work properly causing to leave some proteins in the mucous supernatant. ",
"Red deer sample 37 did not show any bacterial growth therefore no RD4 typing from the isolation could be performed. ",
"The corresponding ML sample detected the subtype Lechtal and was qPCR positive.",
"\n\nAlthough qPCR was positive and the bacterial culture could be classified as Karwendel subtype, it was not possible to subtype ML sample 38.",
"\n\nSample material from the udder lymph node and the retropharyngeal lymph were used for subtyping cattle 41. ",
"RD4 subtyping revealed the Lechtal subtype from bacterial culture and ML, although subtyping from the ML udder lymph node was not possible. ",
"As qPCR of the same sample was negative too, we suggest that the sample material containing the gross lesions was exhausted already by methods from bacteriology.",
"\n\nBacterial culture isolate of cattle sample 44 could be assigned to the Allgäu subtype. ",
"Although the ML qPCR was positive, it was not possible to identify its subtype.",
"\n\nCattle sample 39 did not show any visible lesions after patho-morphological examination. ",
"This cattle was only positive by ante-mortem tests. ",
"In post-mortem routine diagnostic, all lymph nodes were negative by direct qPCR and bacterial culture. ",
"Bacterial growth was only observed when the three lymph nodes, the udder-, the intestinal- and the ileocecal lymph nodes, were pooled. ",
"ML RD4 subtyping was performed separately from all three lymph nodes. ",
"The intestinal lymph node could be subtyped as Lechtal by ML. ",
"ML samples from the udder and the ileocecal lymph nodes could not be assigned to a subtype and qPCR was negative suggesting that the intestinal lymph node was a NVL sample and the remaining two lymph nodes were negative ([Table 7](#pone.0181157.t007){ref-type=\"table\"}).",
"\n\n10.1371/journal.pone.0181157.t007\n\n###### RD4 Subtyping of sample pool.",
"\n\n![](",
"pone.0181157.t007){#pone.0181157.t007g}\n\n Sample No. ",
" Host species Lymph node weight of lymph node for ML \\[g\\] Pathoscore RD4 Subtype (Result qPCR) \n ------------ -------------- ------------ ----------------------------------- ------------ --------------------------- -------------\n 39 Cattle Udder 1.5 0 no subtype (+) Lechtal (+)\n Intestinal 5.5 0 Lechtal (+) \n Ileocecal 4.7 0 no subtype (-) \n\n(+) qPCR positive; (-) qPCR negative\n\nWhile Lechtal subtyping could be performed from almost all ML samples, subtyping of the Allgäu and the Karwendel subtypes was not possible in our study. ",
"Accompanying host DNA apparently is not a problem for ML qPCR detection but might be a problem for RD4 subtyping. ",
"A possibility to overcome this problem would be an additional purification step and the concentration of mycobacterial DNA from ML samples.",
"\n\nML next generation sequencing {#sec022}\n-----------------------------\n\nNext Generation sequencing was used to study the detection sensitivity for *M*. *",
"caprae* specific DNA in the presence of an excess of bovine DNA after enrichment of the mycobacteria by ML. ",
"NGS was performed for 3 samples using an Illumina Hiseq 1500 in a paired-end mode and dual indexing with a read length of 100 bp. ",
"Raw sequencing data were de-multiplexed using the Je\\'s Illumina-illu \\[[@pone.0181157.ref022]\\] tool to reassign the reads to its respective samples. ",
"To ensure high quality data, no mismatch was demultiplexing allowed during and indices with quality scores below 30 were discarded. ",
"After demultiplexing an average number of 6.9 million reads per sample ([Table 8](#pone.0181157.t008){ref-type=\"table\"}) was obtained.",
"\n\n10.1371/journal.pone.0181157.t008\n\n###### Summary of the mapped reads of the 3 samples against the reference genome of *Mycobacterium caprae* and *Bos taurus* using BWA.",
"\n\n![](",
"pone.0181157.t008){#pone.0181157.t008g}\n\n --------------------------------------------------------------------\n Sample No. ",
" Total Reads produced\\ *B*. *",
"taurus* *M*. *",
"caprae*\n by Illumina HiSeq \n ------------ ----------------------- --------------- ---------------\n 40 6567176 6418187 32\n\n 41 7039146 6891839 379\n\n 42 7269492 7110712 56\n --------------------------------------------------------------------\n\nThese reads were mapped against the reference genomes of *M*. *",
"caprae* and *B*. *",
"taurus* to determine the number of mapped reads. ",
"In overall, more than 99% of the reads were mapped to the *B*. *",
"taurus* genome for all the three sequenced samples and only very few reads mapped to the *M*. *",
"caprae* genome. ",
"The highest number of *M*. *",
"caprae* specific reads (379) was found for sample 41 whereas a substantially lower number was found for samples 40 (32) and 42 (56). ",
"Percentage of duplicated reads in all the three ML samples is estimated as less than 1%.",
"\n\nDiscussion {#sec023}\n==========\n\nTo improve detection methods of Mycobacteria we have chosen ML as sample preparation method for enrichment of Mycobacteria in red deer and cattle tissue. ",
"The decision to use ML was made due to its ability to reduce tissue mass, concentrate the target and the ability to substitute commonly used detection methods like direct PCR and bacterial cultivation. ",
"A previously published modular study demonstrated solubilization of artificially spiked animal tissue \\[[@pone.0181157.ref003]\\] but so far ML was not performed using naturally tuberculosis infected samples. ",
"We could show, that ML preparation is suitable for qPCR detection and even more sensitive than bacterial cultivation additionally we received limitary results for RD4 subtyping and WGS.",
"\n\nPathoscoring is a very helpful tool to classify lesions in the lung and in lymph nodes and additionally provides information about the infection stage of an animal. ",
"We used the pathoscore defined by Ballesteros *et al*. ",
"\\[[@pone.0181157.ref019]\\] which referred to post-mortem examinations of macroscopic lesions of European wild boars challenged with a *M*. *",
"bovis* field strain. ",
"Even if lesions of different Tb host species are not completely identical, the described classification criteria reflect very well our pathomorphological observations in red deer and cattle.",
"\n\nAnimals without visible lesions at all were mainly found positive in one of the two medial retropharyngeal lymph nodes by bacteriology suggesting a very early stage of infection \\[[@pone.0181157.ref018]\\]. ",
"By ML qPCR we even detected six NVL lymph node samples which were not detected by bacteriology indicating a much higher sensitivity than bacteriology. ",
"As all six red deer animals were detected positive by well-developed type \"B\" lesions in other tissues, a spread of bacteria might have always occurred to these lymph nodes without generating visible lesions there. ",
"So far, no PCR method performed directly from native sample material without additional processes was described to detect NVL samples. ",
"Although Courcoul *et al*. ",
"\\[[@pone.0181157.ref027]\\] reported a higher sensitivity for homogenate qPCR than for bacteriology, the relation of NVL samples to visible lesions was not specified. ",
"In our study, the sensitivity of bacteriology was higher than for direct qPCR or the homogenate qPCR. ",
"It must be emphasized, that bacteriology was performed with a different decontamination protocol as we used NALC instead of sulphuric acid. ",
"Depending on the decontamination procedure and the culture media, the percentage of detecting infectious material by bacteriology varied from 58% to 80% \\[[@pone.0181157.ref028]\\].",
"\n\nCardoso *et al*. ",
"\\[[@pone.0181157.ref029]\\] estimated a similar sensitivity of bacteriology and PCR when investigating 35 lymph nodes of animals with macroscopic lesions only. ",
"These results are comparable with our direct qPCR which always detects visible lesions of a certain dimension (1 cm and more), but often missed milliar lesions of pathoscore 1 and 2 which were almost always detected by bacteriology and ML qPCR and in some cases, also by the homogenate qPCR. ",
"Contrary to clearly visible macroscopic lesions easily detected by direct qPCR, the homogenate qPCR shows a higher and therefore a more doubtful ct-value than direct qPCR due to the dilution factor of the starting material.",
"\n\nDue to the small amount of sample material used for PCR, it is very likely that PCR results in a false negative result mainly if detecting early stages of infection which do not present visible lesion or lesions of milliar sizes. ",
"The concentration of mycobacteria or mycobacterial DNA and subsequent PCR can solve this problem. ",
"Magnetic capture is an alternative method to ML. ",
"It allows enrichment and specific selection whether of the whole bacteria by anti-*M*. *",
"bovis* antibodies \\[[@pone.0181157.ref008]\\] or by capturing MTC DNA using specific capture oligonucleotides for the PCR amplification of lysed sample material \\[[@pone.0181157.ref007]\\]. ",
"Stewart *et al*. ",
"\\[[@pone.0181157.ref008]\\] detected 2.7% of NVL lymph nodes by bacterial cultivation whereas 70.3% of the same samples tested *M*. *",
"bovis* positive by the IMS-based tests, although the overall sensitivity of IMS-PCR (57,8%) performed directly from the native sample material was lower than for classical mycobacterial cultures (62.%) or IMS based MGIT (mycobacterial growth indicator tube) cultivation (68.2%). ",
"These results are comparable with ML results which detected seven out of 15 (46.7%) NVL lymph nodes while bacteriology detected only one out of 15 (6.7%). ",
"Magnetic capturing of MTC DNA detected 29 (29%) MTC positive cattle and red deer samples out of 100 while the homogenate qPCR detected only 23 (23%). ",
"Therefore, magnetic DNA capturing detected six cattle more which increased the number of positives from 10 to 16 out of 34 cattle. ",
"A discrimination between lesions containing and NVL samples was not performed and the results were only compared with homogenate qPCR but not with bacteriology or methods from pathomorphological inspections \\[[@pone.0181157.ref007]\\].",
"\n\nIMC but not ML or magnetic capture of MTC PCR facilitates cultivation of the selected mycobacteria on special growth media. ",
"Only 107 of 190 positive IMS -MGIT cultures could be confirmed by spoligotyping and the range of different *M*. *",
"bovis* spoligotypes was less diverse than from classical cultivation, which was not surprising if considering that with the antibody used for magnetic beads selection of spoligotypes was performed. ",
"ML detected in almost all cases the *M*. *",
"caprae* Lechtal subtype, but subtypes Allgäu and the Karwendel could only be determined by RD4 subtyping from bacterial cultures. ",
"Although it must be mentioned that due to its rare occurrence only one Allgäu subtype sample and one Karwendel subtype sample were available for our study.",
"\n\nML enables the concentration but not the selection of specific MTC species or MTC DNA. ",
"IMC also detected NVL samples but spoligotyping provided limited results due to the selection of specific subtypes depending on the antibody used. ",
"Magnetic capturing of MTC DNA provides concentration and selection of MTC DNA but the percentage of NVL was not determined. ",
"Moreover, the sensitivity of this method was not compared to bacteriology, the gold standard. ",
"Furthermore, results were only evaluable if the sample material exceeded 3 grams. ",
"With ML one is not limited to a minimum or maximum amount of sample material and the method is also suitable for detecting NVL samples or samples with a few milliar lesions and therefore minimizes false negative results. ",
"Moreover, the method is cheap and uncomplicated but time consuming due to rather long incubation times. ",
"The main disadvantage compared to IM-PCR or magnetic capturing of MTC DNA is that samples which underwent ML contain also host species DNA. ",
"Further purification or selection procedures would provide a solution of this problem. ",
"Magnetic capturing of MTC DNA would be one possibility.",
"\n\nNext Generation sequencing of three ML samples has produced high throughput data with an average of 6.9 million reads per sample. ",
"Strict criteria for demultiplexing and quality scores of indexed reads ensured high quality of the sequence data and prevented errors due to the barcode misassignment. ",
"Mapping these high-quality reads against the reference genome of *M*. *",
"caprae* and *B*. *",
"taurus* revealed that more than 99% of the DNA content belongs to the host genome. *",
"M*. *",
"caprae* specific read count is found to be very low in all three ML samples with the maximum of 379 reads for the sample 41. ",
"In summary, the combination of Matrix Lysis and high throughput sequencing allowed the detection of mycobacterial DNA by moderate sequencing depth. ",
"Deeper sequencing or higher enrichment of mycobacterial DNA is required to characterize the pathogen.",
"\n\nSupporting information {#sec024}\n======================\n\n###### Supporting information regarding [Fig 5](#pone.0181157.g005){ref-type=\"fig\"}.",
"\n\nUnedited argarose gel photos shown in [Fig 5](#pone.0181157.g005){ref-type=\"fig\"}.",
"\n\n(DOCX)\n\n###### \n\nClick here for additional data file.",
"\n\nWe thank Barbara Pohl for providing technical assistance, Stephanie Broeckl for providing us with [Fig 4](#pone.0181157.g004){ref-type=\"fig\"}, the department for molecular biology and the centre for biosafety of the institute for veterinary disease control in Moedling, the Christian Doppler Laboratory for molecular food analysis and the Gene Centre at the LMU Munich.",
"\n\n[^1]: **Competing Interests:**The authors have declared that no competing interests exist.",
"\n\n[^2]: **Conceptualization:** FS.**Data curation:** PR.**Formal analysis:** CL AV PM MFischaleck.**Funding acquisition:** PR FS.**Investigation:** CL AV PM.**Methodology:** CL AV PM MFischaleck.**Project administration:** MFink.**Resources:** PM.**Supervision:** MFink.**Validation:** CL AV PM MFink.**Visualization:** CL.**Writing -- original draft:** CL.**Writing -- review & editing:** MFink.",
"\n"
] | {
"pile_set_name": "PubMed Central"
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[
"Let’s Get Ready To Rumble… Rappapalooza 5!",
"\n\nFor reasons I don’t want to go into (again), I’m feeling an almost overwhelming need for stress relief today. ",
"And, for me at least, nothing does the trick better than laughing along with another set of those hilarious “Epic Rap Battles of History” videos!",
"\n\nBut first, it occurs to me that some of you might not understand my choice of titles for these posts. ",
"Hopefully, this first video will help clear that up:\n\nAnd speaking of “Broken Spleens” – I hope you have 911 on speed dial, because you might just bust a gut watching these videos!",
"\n\nAnd finally, don’t let the title of this next one fool you. ",
"There are no less than 6 crazy Russians battling away in this next video!"
] | {
"pile_set_name": "Pile-CC"
} | [
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0.24203824996948242,
0.08941200375556946,
0.22544842958450317
] | 0.087971 | 7 |
[
"DSA-2378-1 ffmpeg -- several vulnerabilities\n\nSeveral vulnerabilities have been discovered in FFmpeg, a multimedia\nplayer, server and encoder. ",
"Multiple input validations in the decoders\nfor QDM2, VP5, VP6, VMD and SVQ1 files could lead to the execution of\narbitrary code.",
"\n\nFor the stable distribution (squeeze), this problem has been fixed in\nversion 4:0.5.6-3.",
"\n\nFor the unstable distribution (sid), this problem has been fixed in\nversion 4:0.7.3-1 of the libav source package."
] | {
"pile_set_name": "Pile-CC"
} | [
0.0010113399475812912,
0.0006504844641312957,
0.0006192015716806054,
0.0005778502090834081
] | 0.000715 | 4 |
[
"\n<!",
"DOCTYPE html>\n<html lang=\"en\">\n\t<head>\n\t\t<meta charset=\"utf-8\" />\n\t\t<meta name=\"generator\" content=\"JsDoc Toolkit\" />\n\t\t<title>tQuery.",
"RatamahattaMD2Character | tQuery library</title>\n\n\t\t<meta name=\"viewport\" content=\"width=device-width, initial-scale=1.0, maximum-scale=1.0\" />\n\t\t<meta name=\"mobileoptimized\" content=\"0\" />\n\t\n\t\t<link rel=\"stylesheet\" href=\"../css/all.css\" media=\"all\" />\n\t\t<link rel=\"stylesheet\" href=\"../css/handheld.css\" media=\"only screen and (max-width: 660px)\" />\n\t\t<link rel=\"stylesheet\" href=\"../css/handheld.css\" media=\"handheld\" />\n\t\t<link rel=\"stylesheet\" href=\"../css/screen.css\" media=\"screen and (min-width: 661px)\" />\n\n\t\t<script src=\"../javascript/all.js\"></script>\n\t\t<!",
"--[if lt IE 9]>\n\t\t\t<script src=\"../javascript/html5.js\"></script>\n\t\t<![",
"endif]-->\n\t</head>\n\n\t<body>\n\n<div class=\"index\">\n\t<div class=\"menu\">\n\t\t<div class=\"indexLinks\">\n\t\t\t<a href=\"../index.html\">Classes</a>\n\t\t\t<a href=\"../files.html\">Files</a>\n\t\t</div>\n\t\n\t\t<h2 class=\"heading1\">Classes</h2>\n\t\t\n\t\t<input type=\"text\" name=\"classFilter\" class=\"classFilter\" id=\"ClassFilter\" placeholder=\"Filter\"></input>\n\t\t\n\t\t<nav>\n\t\t\t<ul class=\"classList\" id=\"ClassList\">\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.html\">tQuery</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Animation.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Animation</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Animations.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Animations</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.createAnimations.html\">tQuery<span class='break'> </span>.<span class='break'> </span>createAnimations</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Geometry.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Geometry</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Light.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Light</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Loop.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Loop</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Material.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Material</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"MD2Character.html\">tQuery<span class='break'> </span>.<span class='break'> </span>MD2Character</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Mesh.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Mesh</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Node.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Node</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Object3D.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Object3D</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"RatamahattaMD2Character.html\">tQuery<span class='break'> </span>.<span class='break'> </span>RatamahattaMD2Character</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"Spritesheet.html\">tQuery<span class='break'> </span>.<span class='break'> </span>Spritesheet</a></li>\n\t\t\t\t\n\t\t\t\t\t<li><a href=\"../symbols/tQuery.",
"World.html\">tQuery<span class='break'> </span>.<span class='break'> </span>World</a></li>\n\t\t\t\t\n\t\t\t</ul>\n\t\t</nav>\n\t</div>\n\t<div class=\"fineprint\" style=\"clear:both\">\n\t\t<footer>\n\t\t\t\n\t\t\tDocumentation generator: <a href=\"http://code.google.com/p/jsdoc-toolkit/\" target=\"_blank\">JsDoc Toolkit</a> 2.4.0<br />\n\t\t\tTemplate: <a href=\"http://www.thebrightlines.com/2010/05/06/new-template-for-jsdoctoolkit-codeview/\" target=\"_blank\">Codeview</a> 1.2<br />\n\t\t\tGenerated on:\n\t\t\t<time datetime='2012-9-23' pubdate>2012-9-23 18:39</time>\n\t\t</footer>\n\t</div>\n</div>\n\n<div class=\"index indexStatic\"></div>\n\n<div class=\"content\">\n\t<div class=\"innerContent\">\n\t\t<article>\n\t\t\t<header>\n\t\t\t\t<h1 class=\"classTitle\">\n\t\t\t\t\t\n\t\t\t\t\tClass <span>tQuery.",
"RatamahattaMD2Character</span>\n\t\t\t\t</h1>\n\t\t\t\t\n\t\t\t\t<div class=\"intro\">\n\t\t\t\t\t<p class=\"description summary\">\n\t\t\t\t\t\t\n\t\t\t\t\t</p>\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t<ul class=\"summary\">\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t<li>Defined in: <a href=\"../symbols/src/plugins_md2character_tquery.md2character.ratamahatta.js.html\">tquery.md2character.ratamahatta.js</a></li>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<li>Extends <span class=\"fixedFont\">\n\t\t\t\t\t\t\t\t<a href=\"../symbols/tQuery.",
"MD2Character.html\">tQuery.",
"MD2Character</a></span></li>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t</ul>\n\t\t\t\t\t\n\t\t\t\t</div>\n\t\t\t</header>\n\t\t\t\n\t\t\t\n\t\t\t\t<section>\n\t\t\t\t\t<div class=\"props\">\n\t\t\t\t\t\t<table class=\"summaryTable\" cellspacing=\"0\" summary=\"A summary of the constructor documented in the class tQuery.",
"RatamahattaMD2Character.\"",
">\n\t\t\t\t\t\t\t<caption class=\"sectionTitle\">Class Summary</caption>\n\t\t\t\t\t\t\t<thead>\n\t\t\t\t\t\t\t\t<tr>\n\t\t\t\t\t\t\t\t\t<th scope=\"col\">Constructor Attributes</th>\n\t\t\t\t\t\t\t\t\t<th scope=\"col\">Constructor Name and Description</th>\n\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t</thead>\n\t\t\t\t\t\t\t<tbody>\n\t\t\t\t\t\t\t\t<tr>\n\t\t\t\t\t\t\t\t\t<td class=\"attributes\"> </td>\n\t\t\t\t\t\t\t\t\t<td class=\"nameDescription\" >\n\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont\">\n\t\t\t\t\t\t\t\t\t\t\t<b><a href=\"../symbols/tQuery.",
"RatamahattaMD2Character.html#constructor\">tQuery.",
"RatamahattaMD2Character</a></b>()\n\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t<div class=\"description\">implement Ratamahatta character.</div>\n\t\t\t\t\t\t\t\t\t</td>\n\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t</tbody>\n\t\t\t\t\t\t</table>\n\t\t\t\t\t</div>\n\t\t\t\t</section>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\t\n\t\t\t\t<section>\n\t\t\t\t\t\n\t\t\t\t\t\t<nav>\n\t\t\t\t\t\t\t<div class=\"props\">\n\t\t\t\t\t\t\t\t<table class=\"summaryTable\" cellspacing=\"0\" summary=\"A summary of the fields documented in the class tQuery.",
"RatamahattaMD2Character.\"",
">\n\t\t\t\t\t\t\t\t\t<caption class=\"sectionTitle\">Field Summary</caption>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<thead>\n\t\t\t\t\t\t\t\t\t\t<tr>\n\t\t\t\t\t\t\t\t\t\t\t<th scope=\"col\">Field Attributes</th>\n\t\t\t\t\t\t\t\t\t\t\t<th scope=\"col\">Field Name and Description</th>\n\t\t\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t\t\t</thead>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<tbody>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<tr>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"attributes\"><static> </td>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"nameDescription\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont\">\n\t\t\t\t\t\t\t\t\t\t\t\t\ttQuery.",
"RatamahattaMD2Character.<b><a href=\"../symbols/tQuery.",
"RatamahattaMD2Character.html#.hookKeyboard\">hookKeyboard</a></b>\n\t\t\t\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Hook the keyboard</div>\n\t\t\t\t\t\t\t\t\t\t\t\t</td>\n\t\t\t\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<tr>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"attributes\"><static> </td>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"nameDescription\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont\">\n\t\t\t\t\t\t\t\t\t\t\t\t\ttQuery.",
"RatamahattaMD2Character.<b><a href=\"../symbols/tQuery.",
"RatamahattaMD2Character.html#.unhookKeyboard\">unhookKeyboard</a></b>\n\t\t\t\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">unhook the keyboard</div>\n\t\t\t\t\t\t\t\t\t\t\t\t</td>\n\t\t\t\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t</tbody>\n\t\t\t\t\t\t\t\t</table>\n\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t</nav>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t<nav>\n\t\t\t\t\t\t\t<dl class=\"inheritsList\">\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t</dl>\n\t\t\t\t\t\t</nav>\n\t\t\t\t\t\n\t\t\t\t</section>\n\t\t\t\n\t<!--",
"\n\t#### METHODS SUMMARY\n\t-->\n\t\t\t\n\t\t\t\t<section>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"props\">\n\t\t\t\t\t\t<h2 class=\"sectionTitle\">Method Summary</h2>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t<nav>\n\t\t\t\t\t\t\t\t<table class=\"summaryTable\" id=\"MethodsList\" cellspacing=\"0\" summary=\"A summary of the methods documented in the class tQuery.",
"RatamahattaMD2Character.\"",
">\n\t\t\t\t\t\t\t\t\t<thead>\n\t\t\t\t\t\t\t\t\t\t<tr>\n\t\t\t\t\t\t\t\t\t\t\t<th scope=\"col\">Method Attributes</th>\n\t\t\t\t\t\t\t\t\t\t\t<th scope=\"col\">Method Name and Description</th>\n\t\t\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t\t\t</thead>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<tbody>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<tr\n\t\t\t\t\t\t\t\t\t\t\t\t class='item0'\n\t\t\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"attributes\"> </td>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"nameDescription\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont\"><b><a href=\"../symbols/tQuery.",
"RatamahattaMD2Character.html#goForward\">goForward</a></b>(angle)\n\t\t\t\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">go forward to a distance</div>\n\t\t\t\t\t\t\t\t\t\t\t\t</td>\n\t\t\t\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<tr\n\t\t\t\t\t\t\t\t\t\t\t\t class='item1'\n\t\t\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"attributes\"> </td>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"nameDescription\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont\"><b><a href=\"../symbols/tQuery.",
"RatamahattaMD2Character.html#turn\">turn</a></b>(angle)\n\t\t\t\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Turn to an angle</div>\n\t\t\t\t\t\t\t\t\t\t\t\t</td>\n\t\t\t\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<tr\n\t\t\t\t\t\t\t\t\t\t\t\t class='item2'\n\t\t\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"attributes\"> </td>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"nameDescription\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont\"><b><a href=\"../symbols/tQuery.",
"RatamahattaMD2Character.html#turnLeft\">turnLeft</a></b>(angle)\n\t\t\t\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Turn left</div>\n\t\t\t\t\t\t\t\t\t\t\t\t</td>\n\t\t\t\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<tr\n\t\t\t\t\t\t\t\t\t\t\t\t class='item3'\n\t\t\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"attributes\"> </td>\n\t\t\t\t\t\t\t\t\t\t\t\t<td class=\"nameDescription\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont\"><b><a href=\"../symbols/tQuery.",
"RatamahattaMD2Character.html#turnRight\">turnRight</a></b>(angle)\n\t\t\t\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\">Turn right</div>\n\t\t\t\t\t\t\t\t\t\t\t\t</td>\n\t\t\t\t\t\t\t\t\t\t\t</tr>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t</tbody>\n\t\t\t\t\t\t\t\t</table>\n\t\t\t\t\t\t\t</nav>\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t<nav>\n\t\t\t\t\t\t\t\t<dl class=\"inheritsList\" id=\"MethodsListInherited\">\n\t\t\t\t\t\t\t\t<dt>Methods borrowed from class <span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html\">tQuery.",
"MD2Character</a></span>: </dt><dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#animation\">animation</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#container\">container</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#destroy\">destroy</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#isLoaded\">isLoaded</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#load\">load</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#scale\">scale</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#setPlaybackRate\">setPlaybackRate</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#setSkin\">setSkin</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#setWeapon\">setWeapon</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#setWireframe\">setWireframe</a></span></dd> <dd><span class='fixedFont'><a href=\"../symbols/tQuery.",
"MD2Character.html#update\">update</a></span></dd>\n\t\t\t\t\t\t\t\t</dl>\n\t\t\t\t\t\t\t</nav>\n\t\t\t\t\t\t\n\t\t\t\t\t</div>\n\t\t\t\t</section>\n\t\t\t\n\t\t\t\n\t<!--",
"\n\t#### EVENTS SUMMARY\n\t-->\n\t\t\t\n\t<!--",
"\n\t#### CONSTRUCTOR DETAILS\n\t-->\n\t\t\t\n\t\t\t\t<section>\n\t\t\t\t\t<div class=\"details props\">\n\t\t\t\t\t\t<div class=\"innerProps\">\n\t\t\t\t\t\t\t<h2 class=\"sectionTitle\" id=\"constructor\">\n\t\t\t\t\t\t\t\tClass Detail\n\t\t\t\t\t\t\t</h2>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<div class=\"fixedFont\">\n\t\t\t\t\t\t\t\t<b>tQuery.",
"RatamahattaMD2Character</b>()\n\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<div class=\"description\">\n\t\t\t\t\t\t\t\timplement Ratamahatta character.",
"\nTODO seems to have issue with multilple characters. ",
"it may be about material \ncaching. ",
"seems typically a microcache issue.",
"\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t</div>\n\t\t\t\t\t</div>\n\t\t\t\t</section>\n\t\t\t\n\t<!--",
"\n\t#### FIELD DETAILS\n\t-->\n\t\t\t\n\t\t\t\t<section>\n\t\t\t\t\t<div class=\"details props\">\n\t\t\t\t\t\t<div class=\"innerProps\">\n\t\t\t\t\t\t\t<h2 class=\"sectionTitle\">\n\t\t\t\t\t\t\t\tField Detail\n\t\t\t\t\t\t\t</h2>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t<div class=\"fixedFont heading\" id=\".hookKeyboard\">\n\t\t\t\t\t\t\t\t\t<span class='lighter'>\n\t\t\t\t\t\t\t\t\t<static> \n\t\t\t\t\t\t\t\t\t</span>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"light\">tQuery.",
"RatamahattaMD2Character.</span><b>hookKeyboard</b>\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t<div class=\"description\">\n\t\t\t\t\t\t\t\t\tHook the keyboard\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t<br />\n\t\t\t\t\t\t\t\t\t\t<i>Defined in: </i> <a href=\"../symbols/src/plugins_minecraft_tquery.minecraftchar.keyboard.js.html\">tquery.minecraftchar.keyboard.js</a>.",
"\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t<div class=\"hr\"></div>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t<div class=\"fixedFont heading\" id=\".unhookKeyboard\">\n\t\t\t\t\t\t\t\t\t<span class='lighter'>\n\t\t\t\t\t\t\t\t\t<static> \n\t\t\t\t\t\t\t\t\t</span>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"light\">tQuery.",
"RatamahattaMD2Character.</span><b>unhookKeyboard</b>\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t<div class=\"description\">\n\t\t\t\t\t\t\t\t\tunhook the keyboard\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t<br />\n\t\t\t\t\t\t\t\t\t\t<i>Defined in: </i> <a href=\"../symbols/src/plugins_minecraft_tquery.minecraftchar.keyboard.js.html\">tquery.minecraftchar.keyboard.js</a>.",
"\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t</div>\n\t\t\t\t\t</div>\n\t\t\t\t</section>\n\t\t\t\n\t<!--",
"\n\t#### METHOD DETAILS\n\t-->\t\t\n\t\t\t\n\t\t\t\t<section>\n\t\t\t\t\t<div class=\"details props\">\n\t\t\t\t\t\t<div class=\"innerProps\">\n\t\t\t\t\t\t\t<h2 class=\"sectionTitle\">\n\t\t\t\t\t\t\t\tMethod Detail\n\t\t\t\t\t\t\t</h2>\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<ul class=\"methodDetail\" id=\"MethodDetail\">\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<li \n\t\t\t\t\t\t\t\t\t\t class='item0'\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont heading\" id=\"goForward\">\n\t\t\t\t\t\t\t\t\t\t\t<span class='lighter'>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t</span>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<b>goForward</b>(angle)\n\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t<div class=\"description\">\n\t\t\t\t\t\t\t\t\t\t\tgo forward to a distance\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<dl class=\"detailList params\">\n\t\t\t\t\t\t\t\t\t\t\t\t<dt class=\"heading\">Parameters:</dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"light fixedFont\">{Number}</span> <b>angle</b>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t</dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<dd>angle to turn to in radian</dd>\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t</dl>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t<div class=\"hr\"></div>\n\t\t\t\t\t\t\t\t\t</li>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<li \n\t\t\t\t\t\t\t\t\t\t class='item1'\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont heading\" id=\"turn\">\n\t\t\t\t\t\t\t\t\t\t\t<span class='lighter'>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t</span>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<b>turn</b>(angle)\n\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t<div class=\"description\">\n\t\t\t\t\t\t\t\t\t\t\tTurn to an angle\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<dl class=\"detailList params\">\n\t\t\t\t\t\t\t\t\t\t\t\t<dt class=\"heading\">Parameters:</dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"light fixedFont\">{Number}</span> <b>angle</b>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t</dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<dd>angle to turn to in radian</dd>\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t</dl>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t<div class=\"hr\"></div>\n\t\t\t\t\t\t\t\t\t</li>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<li \n\t\t\t\t\t\t\t\t\t\t class='item2'\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont heading\" id=\"turnLeft\">\n\t\t\t\t\t\t\t\t\t\t\t<span class='lighter'>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t</span>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<b>turnLeft</b>(angle)\n\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t<div class=\"description\">\n\t\t\t\t\t\t\t\t\t\t\tTurn left\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<dl class=\"detailList params\">\n\t\t\t\t\t\t\t\t\t\t\t\t<dt class=\"heading\">Parameters:</dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"light fixedFont\">{Number}</span> <b>angle</b>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t</dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<dd>angle to turn to in radian</dd>\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t</dl>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t<div class=\"hr\"></div>\n\t\t\t\t\t\t\t\t\t</li>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<li \n\t\t\t\t\t\t\t\t\t\t class='item3'\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t<div class=\"fixedFont heading\" id=\"turnRight\">\n\t\t\t\t\t\t\t\t\t\t\t<span class='lighter'>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t</span>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<b>turnRight</b>(angle)\n\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t<div class=\"description\">\n\t\t\t\t\t\t\t\t\t\t\tTurn right\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<dl class=\"detailList params\">\n\t\t\t\t\t\t\t\t\t\t\t\t<dt class=\"heading\">Parameters:</dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"light fixedFont\">{Number}</span> <b>angle</b>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t</dt>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<dd>angle to turn to in 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"NEWS ANALYSIS\n\nDon’t Just Sit There\n\nBy GRETCHEN REYNOLDS\n\nPublished: April 28, 2012\n\nONE lesson I’ve learned while writing about fitness is that few things impinge on an active life as much as writing about fitness — all that time spent hunched before a computer or puzzling over scientific journals, the countless hours of feckless, seated procrastination. ",
"While writing about the benefits of exercise, my muscles slackened. ",
"Fat seeped insidiously into my blood, liver and ventricles. ",
"Stupor infiltrated my brain.",
"\n\nAnna Raff\n\nWe all know by now that being inactive is unhealthy. ",
"But far too many of us think that being inactive is something that happens to other people.",
"\n\nStudies of daily movement patterns, though, show that your typical modern exerciser, even someone who runs, subsequently sits for hours afterward, often moving less over all than on days when he or she does not work out.",
"\n\nThe health consequences are swift, pervasive and punishing. ",
"In a noteworthy recent experiment conducted by scientists at the University of Massachusetts and other institutions, a group of healthy young men donned a clunky platform shoe with a 4-inch heel on their right foot, leaving the left leg to dangle above the ground. ",
"For two days, the men hopped about using crutches (and presumably gained some respect for those people who regularly toddle about in platform heels). ",
"Each man’s left leg never touched the ground. ",
"Its muscles didn’t contract. ",
"It was fully sedentary.",
"\n\nAfter two days, the scientists biopsied muscles in both legs and found multiple genes now being expressed differently in each man’s two legs. ",
"Gene activity in the left leg suggested that DNA repair mechanisms had been disrupted, insulin response was dropping, oxidative stress was rising, and metabolic activity within individual muscle cells was slowing after only 48 hours of inactivity.",
"\n\nIn similar experiments with lab animals, casts have been placed on their back legs, after which the animals rapidly developed noxious cellular changes throughout their bodies, and not merely in the immobilized muscles. ",
"In particular, they produced substantially less of an enzyme that dissolves fat in the bloodstream. ",
"As a result, in animals and humans, fat can accumulate and migrate to the heart or liver, potentially leading to cardiac disease and diabetes.",
"\n\nTo see the results of such inactivity, scientists with the National Cancer Institute spent eight years following almost 250,000 American adults. ",
"The participants answered detailed questions about how much time they spent commuting, watching TV, sitting before a computer and exercising, as well as about their general health. ",
"At the start of the study, none suffered from heart disease, cancer or diabetes.",
"\n\nBut after eight years, many were ill and quite a few had died. ",
"The sick and deceased were also in most cases sedentary. ",
"Those who watched TV for seven or more hours a day proved to have a much higher risk of premature death than those who sat in front of the television less often. (",
"Television viewing is a widely used measure of sedentary time.)",
"\n\nExercise only slightly lessened the health risks of sitting. ",
"People in the study who exercised for seven hours or more a week but spent at least seven hours a day in front of the television were more likely to die prematurely than the small group who worked out seven hours a week and watched less than an hour of TV a day.",
"\n\nIf those numbers seem abstract, consider a blunt new Australian study. ",
"In it, researchers determined that watching an hour of television can snip 22 minutes from someone’s life. ",
"If an average man watched no TV in his adult life, the authors concluded, his life span might be 1.8 years longer, and a TV-less woman might live for a year and half longer than otherwise.",
"\n\nSo I canceled our cable, leaving my 14-year-old son staggered. ",
"I’d deprived him of his favorite shows on The Food Network, a channel that, combined with sitting, explains much about the American waistline. (",
"Thankfully, my son is blessed with his father’s lanky, string-bean physique.)",
"\n\nI also conduct more of my daily business upright. ",
"In an inspiring study being published next month in Diabetes Care, scientists at the Baker IDI Heart and Diabetes Institute in Melbourne, Australia, had 19 adults sit completely still for seven hours or, on a separate day, rise every 20 minutes and walk leisurely on a treadmill (handily situated next to their chairs) for two minutes. ",
"On another day, they had the volunteers jog gently during their two-minute breaks.",
"\n\nWhen the volunteers remained stationary for the full seven hours, their blood sugar spiked and insulin levels were out of whack. ",
"But when they broke up the hours with movement, even that short two-minute stroll, their blood sugar levels remained stable. ",
"Interestingly, the jogging didn’t improve blood sugar regulation any more than standing and walking did. ",
"What was important, the scientists concluded, was simply breaking up the long, interminable hours of sitting.",
"\n\nEqually beguiling, at least for me, since I’m shallow, were results from experiments at the University of Massachusetts showing that when volunteers stood all day — nothing else; no walking or jogging; just standing — they burned hundreds more calories than when they sat for the same period of time.",
"\n\nSo every 20 minutes or so, I now rise. ",
"I don’t have a desk treadmill; my office is too small, and my budget too slim. ",
"But I prop my papers on a music stand and read standing up. ",
"I prowl my office while I talk on the phone. (",
"I also stand on one foot when I brush my teeth at night, which has little to do with reducing inactivity but may be one of the more transformative actions I’ve picked up from researching fitness. ",
"My balance and physical confidence have improved, and my husband is consistently amused, which is not a bad foundation for marital health.)",
"\n\nI run for three or four miles most days, too, and grunt through 20 push-ups most mornings. ",
"There are health and fitness benefits from endurance and weight training that standing up can’t match. ",
"In particular, aerobic workouts have been shown to improve brainpower, and I shudder to imagine the state of my memory if I didn’t run. ",
"But I’m not planning any marathons (been there, done that, walked down stairs backward for days). ",
"I want foundational health. ",
"I want my insulin levels in check and my fat-fighting enzymes robust. ",
"I have plans for those extra 18 months of life span that not sitting might provide.",
"\n\nThe “Phys Ed” columnist for The New York Times and the author of a new book on science and exercise, “The First 20 Minutes.”",
"\n\nBut all the toys and perks belie the frenetic pace here, and many employees acknowledge that life at Google can be hard on fragile egos.",
"\n\nSure, the amenities are seductive, says Blaise Pabon, an enterprise sales engineer, but “when you get to a place like this, it can tear you apart” if you don’t find a way to handle the hard-driving culture.",
"\n\nEmployees coming from fast-paced fields, already accustomed to demanding bosses and long hours, say Google pushes them to produce at a pace even faster than they could have imagined. ",
"Google’s co-founder and chief executive, Larry Page, recently promised on the company Web site to maintain “a healthy disregard for the impossible.”",
"\n\nLittle wonder, then, that among the hundreds of free classes that Google offers to employees here, one of the most popular is called S.I.Y., for “Search Inside Yourself.” ",
"It is the brainchild of Chade-Meng Tan, 41, a tall, thin, soft-spoken engineer who arrived at Google in 2000 as Employee No. ",
"107.",
"\n\nThink of S.I.Y. as the Zen of Google. ",
"Mr. Tan dreamed up the course and refined it with the help of nine experts in the use of mindfulness at work. ",
"And in a time when Google has come under new scrutiny from European and United States regulators over privacy and other issues, a class in mindfulness might be a very good thing.",
"\n\nThe class has three steps: attention training, self-knowledge and self-mastery, and the creation of useful mental habits.",
"\n\nIf it sounds a bit touchy-feely, consider this: More than 1,000 Google employees have taken the class, and there’s a waiting list of 30 when it’s offered, four times a year. ",
"The class accepts 60 people and runs seven weeks.",
"\n\nRichard Fernandez, director of executive development and a psychologist by training, says he sees a significant difference in his work behavior since taking the class. “",
"I’m definitely much more resilient as a leader,” he says. “",
"I listen more carefully and with less reactivity in high-stakes meetings. ",
"I work with a lot of senior executives who can be very demanding, but that doesn’t faze me anymore. ",
"It’s almost an emotional and mental bank account. ",
"I’ve now got much more of a buffer there.”",
"\n\nMr. Tan says the course has received good reviews. “",
"In anonymous surveys, on average, participants rated it around 4.75 out of 5,” he says. “",
"Awareness is spread almost entirely by word-of-mouth by alumni, and that alone already created more demand than we can currently serve.”",
"\n\n“As technology pushes us faster, we have to adapt to new ways of doing business in this new millennium,” says Mark Tauber, senior vice president and publisher at HarperOne. “",
"We believe that Meng’s book lays the groundwork for a new national conversation about work and what work means to us.”",
"\n\nBut what is Mr. Tan’s ultimate goal? ",
"A Buddhist for many years, he says without irony that he wants to create world peace. “",
"I was always very different from the other kids,” he says. “",
"I have an I.Q. of 156. ",
"I didn’t play sports. ",
"I thought big. ",
"I thought I could achieve great things. ",
"I don’t want to sound megalomaniac, but my whole life is about doing something for the world, from as far back as I can remember.”",
"\n\nBorn and raised in Singapore, Mr. Tan describes his childhood as “very unhappy.”"
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0.014409981667995453,
0.0030011325143277645,
0.0007599341915920377,
0.0006981834303587675,
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0.0006865004543215036,
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] | 0.008609 | 88 |
[
"// mksyscall.pl -l32 -arm -tags linux,arm syscall_linux.go syscall_linux_arm.go\n// Code generated by the command above; see README.md. ",
"DO NOT EDIT.",
"\n\n// +build linux,arm\n\npackage unix\n\nimport (\n\t\"syscall\"\n\t\"unsafe\"\n)\n\nvar _ syscall.",
"Errno\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc fchmodat(dirfd int, path string, mode uint32) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_FCHMODAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(mode))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc ioctl(fd int, req uint, arg uintptr) (err error) {\n\t_, _, e1 := Syscall(SYS_IOCTL, uintptr(fd), uintptr(req), uintptr(arg))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Linkat(olddirfd int, oldpath string, newdirfd int, newpath string, flags int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(oldpath)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(newpath)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall6(SYS_LINKAT, uintptr(olddirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(newdirfd), uintptr(unsafe.",
"Pointer(_p1)), uintptr(flags), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc openat(dirfd int, path string, flags int, mode uint32) (fd int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tr0, _, e1 := Syscall6(SYS_OPENAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(flags), uintptr(mode), 0, 0)\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc ppoll(fds *PollFd, nfds int, timeout *Timespec, sigmask *Sigset_t) (n int, err error) {\n\tr0, _, e1 := Syscall6(SYS_PPOLL, uintptr(unsafe.",
"Pointer(fds)), uintptr(nfds), uintptr(unsafe.",
"Pointer(timeout)), uintptr(unsafe.",
"Pointer(sigmask)), 0, 0)\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Readlinkat(dirfd int, path string, buf []byte) (n int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 unsafe.",
"Pointer\n\tif len(buf) > 0 {\n\t\t_p1 = unsafe.",
"Pointer(&buf[0])\n\t} else {\n\t\t_p1 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_READLINKAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(_p1), uintptr(len(buf)), 0, 0)\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Symlinkat(oldpath string, newdirfd int, newpath string) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(oldpath)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(newpath)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_SYMLINKAT, uintptr(unsafe.",
"Pointer(_p0)), uintptr(newdirfd), uintptr(unsafe.",
"Pointer(_p1)))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Unlinkat(dirfd int, path string, flags int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_UNLINKAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(flags))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc utimes(path string, times *[2]Timeval) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_UTIMES, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(times)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc utimensat(dirfd int, path string, times *[2]Timespec, flags int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall6(SYS_UTIMENSAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(times)), uintptr(flags), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc futimesat(dirfd int, path *byte, times *[2]Timeval) (err error) {\n\t_, _, e1 := Syscall(SYS_FUTIMESAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(path)), uintptr(unsafe.",
"Pointer(times)))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getcwd(buf []byte) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(buf) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&buf[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall(SYS_GETCWD, uintptr(_p0), uintptr(len(buf)), 0)\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc wait4(pid int, wstatus *_C_int, options int, rusage *Rusage) (wpid int, err error) {\n\tr0, _, e1 := Syscall6(SYS_WAIT4, uintptr(pid), uintptr(unsafe.",
"Pointer(wstatus)), uintptr(options), uintptr(unsafe.",
"Pointer(rusage)), 0, 0)\n\twpid = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc KeyctlInt(cmd int, arg2 int, arg3 int, arg4 int, arg5 int) (ret int, err error) {\n\tr0, _, e1 := Syscall6(SYS_KEYCTL, uintptr(cmd), uintptr(arg2), uintptr(arg3), uintptr(arg4), uintptr(arg5), 0)\n\tret = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc KeyctlBuffer(cmd int, arg2 int, buf []byte, arg5 int) (ret int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(buf) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&buf[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_KEYCTL, uintptr(cmd), uintptr(arg2), uintptr(_p0), uintptr(len(buf)), uintptr(arg5), 0)\n\tret = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc keyctlJoin(cmd int, arg2 string) (ret int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(arg2)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tr0, _, e1 := Syscall(SYS_KEYCTL, uintptr(cmd), uintptr(unsafe.",
"Pointer(_p0)), 0)\n\tret = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc keyctlSearch(cmd int, arg2 int, arg3 string, arg4 string, arg5 int) (ret int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(arg3)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(arg4)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tr0, _, e1 := Syscall6(SYS_KEYCTL, uintptr(cmd), uintptr(arg2), uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), uintptr(arg5), 0)\n\tret = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc keyctlIOV(cmd int, arg2 int, payload []Iovec, arg5 int) (err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(payload) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&payload[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall6(SYS_KEYCTL, uintptr(cmd), uintptr(arg2), uintptr(_p0), uintptr(len(payload)), uintptr(arg5), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc keyctlDH(cmd int, arg2 *KeyctlDHParams, buf []byte) (ret int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(buf) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&buf[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_KEYCTL, uintptr(cmd), uintptr(unsafe.",
"Pointer(arg2)), uintptr(_p0), uintptr(len(buf)), 0, 0)\n\tret = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc ptrace(request int, pid int, addr uintptr, data uintptr) (err error) {\n\t_, _, e1 := Syscall6(SYS_PTRACE, uintptr(request), uintptr(pid), uintptr(addr), uintptr(data), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc reboot(magic1 uint, magic2 uint, cmd int, arg string) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(arg)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall6(SYS_REBOOT, uintptr(magic1), uintptr(magic2), uintptr(cmd), uintptr(unsafe.",
"Pointer(_p0)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc mount(source string, target string, fstype string, flags uintptr, data *byte) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(source)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(target)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p2 *byte\n\t_p2, err = BytePtrFromString(fstype)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall6(SYS_MOUNT, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), uintptr(unsafe.",
"Pointer(_p2)), uintptr(flags), uintptr(unsafe.",
"Pointer(data)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Acct(path string) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_ACCT, uintptr(unsafe.",
"Pointer(_p0)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc AddKey(keyType string, description string, payload []byte, ringid int) (id int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(keyType)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(description)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p2 unsafe.",
"Pointer\n\tif len(payload) > 0 {\n\t\t_p2 = unsafe.",
"Pointer(&payload[0])\n\t} else {\n\t\t_p2 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_ADD_KEY, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), uintptr(_p2), uintptr(len(payload)), uintptr(ringid), 0)\n\tid = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Adjtimex(buf *Timex) (state int, err error) {\n\tr0, _, e1 := Syscall(SYS_ADJTIMEX, uintptr(unsafe.",
"Pointer(buf)), 0, 0)\n\tstate = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Chdir(path string) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_CHDIR, uintptr(unsafe.",
"Pointer(_p0)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Chroot(path string) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_CHROOT, uintptr(unsafe.",
"Pointer(_p0)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc ClockGettime(clockid int32, time *Timespec) (err error) {\n\t_, _, e1 := Syscall(SYS_CLOCK_GETTIME, uintptr(clockid), uintptr(unsafe.",
"Pointer(time)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Close(fd int) (err error) {\n\t_, _, e1 := Syscall(SYS_CLOSE, uintptr(fd), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc CopyFileRange(rfd int, roff *int64, wfd int, woff *int64, len int, flags int) (n int, err error) {\n\tr0, _, e1 := Syscall6(SYS_COPY_FILE_RANGE, uintptr(rfd), uintptr(unsafe.",
"Pointer(roff)), uintptr(wfd), uintptr(unsafe.",
"Pointer(woff)), uintptr(len), uintptr(flags))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Dup(oldfd int) (fd int, err error) {\n\tr0, _, e1 := Syscall(SYS_DUP, uintptr(oldfd), 0, 0)\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Dup3(oldfd int, newfd int, flags int) (err error) {\n\t_, _, e1 := Syscall(SYS_DUP3, uintptr(oldfd), uintptr(newfd), uintptr(flags))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc EpollCreate(size int) (fd int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_EPOLL_CREATE, uintptr(size), 0, 0)\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc EpollCreate1(flag int) (fd int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_EPOLL_CREATE1, uintptr(flag), 0, 0)\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc EpollCtl(epfd int, op int, fd int, event *EpollEvent) (err error) {\n\t_, _, e1 := RawSyscall6(SYS_EPOLL_CTL, uintptr(epfd), uintptr(op), uintptr(fd), uintptr(unsafe.",
"Pointer(event)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Eventfd(initval uint, flags int) (fd int, err error) {\n\tr0, _, e1 := Syscall(SYS_EVENTFD2, uintptr(initval), uintptr(flags), 0)\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Exit(code int) {\n\tSyscall(SYS_EXIT_GROUP, uintptr(code), 0, 0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Faccessat(dirfd int, path string, mode uint32, flags int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall6(SYS_FACCESSAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(mode), uintptr(flags), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Fallocate(fd int, mode uint32, off int64, len int64) (err error) {\n\t_, _, e1 := Syscall6(SYS_FALLOCATE, uintptr(fd), uintptr(mode), uintptr(off), uintptr(off>>32), uintptr(len), uintptr(len>>32))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Fchdir(fd int) (err error) {\n\t_, _, e1 := Syscall(SYS_FCHDIR, uintptr(fd), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Fchmod(fd int, mode uint32) (err error) {\n\t_, _, e1 := Syscall(SYS_FCHMOD, uintptr(fd), uintptr(mode), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Fchownat(dirfd int, path string, uid int, gid int, flags int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall6(SYS_FCHOWNAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(uid), uintptr(gid), uintptr(flags), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc fcntl(fd int, cmd int, arg int) (val int, err error) {\n\tr0, _, e1 := Syscall(SYS_FCNTL, uintptr(fd), uintptr(cmd), uintptr(arg))\n\tval = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Fdatasync(fd int) (err error) {\n\t_, _, e1 := Syscall(SYS_FDATASYNC, uintptr(fd), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Flock(fd int, how int) (err error) {\n\t_, _, e1 := Syscall(SYS_FLOCK, uintptr(fd), uintptr(how), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Fsync(fd int) (err error) {\n\t_, _, e1 := Syscall(SYS_FSYNC, uintptr(fd), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getdents(fd int, buf []byte) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(buf) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&buf[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall(SYS_GETDENTS64, uintptr(fd), uintptr(_p0), uintptr(len(buf)))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getpgid(pid int) (pgid int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_GETPGID, uintptr(pid), 0, 0)\n\tpgid = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getpid() (pid int) {\n\tr0, _, _ := RawSyscall(SYS_GETPID, 0, 0, 0)\n\tpid = int(r0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getppid() (ppid int) {\n\tr0, _, _ := RawSyscall(SYS_GETPPID, 0, 0, 0)\n\tppid = int(r0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getpriority(which int, who int) (prio int, err error) {\n\tr0, _, e1 := Syscall(SYS_GETPRIORITY, uintptr(which), uintptr(who), 0)\n\tprio = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getrandom(buf []byte, flags int) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(buf) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&buf[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall(SYS_GETRANDOM, uintptr(_p0), uintptr(len(buf)), uintptr(flags))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getrusage(who int, rusage *Rusage) (err error) {\n\t_, _, e1 := RawSyscall(SYS_GETRUSAGE, uintptr(who), uintptr(unsafe.",
"Pointer(rusage)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getsid(pid int) (sid int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_GETSID, uintptr(pid), 0, 0)\n\tsid = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Gettid() (tid int) {\n\tr0, _, _ := RawSyscall(SYS_GETTID, 0, 0, 0)\n\ttid = int(r0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getxattr(path string, attr string, dest []byte) (sz int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(attr)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p2 unsafe.",
"Pointer\n\tif len(dest) > 0 {\n\t\t_p2 = unsafe.",
"Pointer(&dest[0])\n\t} else {\n\t\t_p2 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_GETXATTR, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), uintptr(_p2), uintptr(len(dest)), 0, 0)\n\tsz = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc InotifyAddWatch(fd int, pathname string, mask uint32) (watchdesc int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(pathname)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tr0, _, e1 := Syscall(SYS_INOTIFY_ADD_WATCH, uintptr(fd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(mask))\n\twatchdesc = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc InotifyInit1(flags int) (fd int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_INOTIFY_INIT1, uintptr(flags), 0, 0)\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc InotifyRmWatch(fd int, watchdesc uint32) (success int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_INOTIFY_RM_WATCH, uintptr(fd), uintptr(watchdesc), 0)\n\tsuccess = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Kill(pid int, sig syscall.",
"Signal) (err error) {\n\t_, _, e1 := RawSyscall(SYS_KILL, uintptr(pid), uintptr(sig), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Klogctl(typ int, buf []byte) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(buf) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&buf[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall(SYS_SYSLOG, uintptr(typ), uintptr(_p0), uintptr(len(buf)))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Lgetxattr(path string, attr string, dest []byte) (sz int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(attr)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p2 unsafe.",
"Pointer\n\tif len(dest) > 0 {\n\t\t_p2 = unsafe.",
"Pointer(&dest[0])\n\t} else {\n\t\t_p2 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_LGETXATTR, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), uintptr(_p2), uintptr(len(dest)), 0, 0)\n\tsz = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Listxattr(path string, dest []byte) (sz int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 unsafe.",
"Pointer\n\tif len(dest) > 0 {\n\t\t_p1 = unsafe.",
"Pointer(&dest[0])\n\t} else {\n\t\t_p1 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall(SYS_LISTXATTR, uintptr(unsafe.",
"Pointer(_p0)), uintptr(_p1), uintptr(len(dest)))\n\tsz = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Llistxattr(path string, dest []byte) (sz int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 unsafe.",
"Pointer\n\tif len(dest) > 0 {\n\t\t_p1 = unsafe.",
"Pointer(&dest[0])\n\t} else {\n\t\t_p1 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall(SYS_LLISTXATTR, uintptr(unsafe.",
"Pointer(_p0)), uintptr(_p1), uintptr(len(dest)))\n\tsz = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Lremovexattr(path string, attr string) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(attr)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_LREMOVEXATTR, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Lsetxattr(path string, attr string, data []byte, flags int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(attr)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p2 unsafe.",
"Pointer\n\tif len(data) > 0 {\n\t\t_p2 = unsafe.",
"Pointer(&data[0])\n\t} else {\n\t\t_p2 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall6(SYS_LSETXATTR, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), uintptr(_p2), uintptr(len(data)), uintptr(flags), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Mkdirat(dirfd int, path string, mode uint32) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_MKDIRAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(mode))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Mknodat(dirfd int, path string, mode uint32, dev int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall6(SYS_MKNODAT, uintptr(dirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(mode), uintptr(dev), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Nanosleep(time *Timespec, leftover *Timespec) (err error) {\n\t_, _, e1 := Syscall(SYS_NANOSLEEP, uintptr(unsafe.",
"Pointer(time)), uintptr(unsafe.",
"Pointer(leftover)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc PivotRoot(newroot string, putold string) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(newroot)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(putold)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_PIVOT_ROOT, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc prlimit(pid int, resource int, newlimit *Rlimit, old *Rlimit) (err error) {\n\t_, _, e1 := RawSyscall6(SYS_PRLIMIT64, uintptr(pid), uintptr(resource), uintptr(unsafe.",
"Pointer(newlimit)), uintptr(unsafe.",
"Pointer(old)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Prctl(option int, arg2 uintptr, arg3 uintptr, arg4 uintptr, arg5 uintptr) (err error) {\n\t_, _, e1 := Syscall6(SYS_PRCTL, uintptr(option), uintptr(arg2), uintptr(arg3), uintptr(arg4), uintptr(arg5), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Pselect(nfd int, r *FdSet, w *FdSet, e *FdSet, timeout *Timespec, sigmask *Sigset_t) (n int, err error) {\n\tr0, _, e1 := Syscall6(SYS_PSELECT6, uintptr(nfd), uintptr(unsafe.",
"Pointer(r)), uintptr(unsafe.",
"Pointer(w)), uintptr(unsafe.",
"Pointer(e)), uintptr(unsafe.",
"Pointer(timeout)), uintptr(unsafe.",
"Pointer(sigmask)))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc read(fd int, p []byte) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(p) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&p[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall(SYS_READ, uintptr(fd), uintptr(_p0), uintptr(len(p)))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Removexattr(path string, attr string) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(attr)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_REMOVEXATTR, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Renameat(olddirfd int, oldpath string, newdirfd int, newpath string) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(oldpath)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(newpath)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall6(SYS_RENAMEAT, uintptr(olddirfd), uintptr(unsafe.",
"Pointer(_p0)), uintptr(newdirfd), uintptr(unsafe.",
"Pointer(_p1)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc RequestKey(keyType string, description string, callback string, destRingid int) (id int, err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(keyType)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(description)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p2 *byte\n\t_p2, err = BytePtrFromString(callback)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tr0, _, e1 := Syscall6(SYS_REQUEST_KEY, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), uintptr(unsafe.",
"Pointer(_p2)), uintptr(destRingid), 0, 0)\n\tid = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setdomainname(p []byte) (err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(p) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&p[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall(SYS_SETDOMAINNAME, uintptr(_p0), uintptr(len(p)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Sethostname(p []byte) (err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(p) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&p[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall(SYS_SETHOSTNAME, uintptr(_p0), uintptr(len(p)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setpgid(pid int, pgid int) (err error) {\n\t_, _, e1 := RawSyscall(SYS_SETPGID, uintptr(pid), uintptr(pgid), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setsid() (pid int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_SETSID, 0, 0, 0)\n\tpid = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Settimeofday(tv *Timeval) (err error) {\n\t_, _, e1 := RawSyscall(SYS_SETTIMEOFDAY, uintptr(unsafe.",
"Pointer(tv)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setns(fd int, nstype int) (err error) {\n\t_, _, e1 := Syscall(SYS_SETNS, uintptr(fd), uintptr(nstype), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setpriority(which int, who int, prio int) (err error) {\n\t_, _, e1 := Syscall(SYS_SETPRIORITY, uintptr(which), uintptr(who), uintptr(prio))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setxattr(path string, attr string, data []byte, flags int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p1 *byte\n\t_p1, err = BytePtrFromString(attr)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\tvar _p2 unsafe.",
"Pointer\n\tif len(data) > 0 {\n\t\t_p2 = unsafe.",
"Pointer(&data[0])\n\t} else {\n\t\t_p2 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall6(SYS_SETXATTR, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(_p1)), uintptr(_p2), uintptr(len(data)), uintptr(flags), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Sync() {\n\tSyscall(SYS_SYNC, 0, 0, 0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Syncfs(fd int) (err error) {\n\t_, _, e1 := Syscall(SYS_SYNCFS, uintptr(fd), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Sysinfo(info *Sysinfo_t) (err error) {\n\t_, _, e1 := RawSyscall(SYS_SYSINFO, uintptr(unsafe.",
"Pointer(info)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Tee(rfd int, wfd int, len int, flags int) (n int64, err error) {\n\tr0, r1, e1 := Syscall6(SYS_TEE, uintptr(rfd), uintptr(wfd), uintptr(len), uintptr(flags), 0, 0)\n\tn = int64(int64(r1)<<32 | int64(r0))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Tgkill(tgid int, tid int, sig syscall.",
"Signal) (err error) {\n\t_, _, e1 := RawSyscall(SYS_TGKILL, uintptr(tgid), uintptr(tid), uintptr(sig))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Times(tms *Tms) (ticks uintptr, err error) {\n\tr0, _, e1 := RawSyscall(SYS_TIMES, uintptr(unsafe.",
"Pointer(tms)), 0, 0)\n\tticks = uintptr(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Umask(mask int) (oldmask int) {\n\tr0, _, _ := RawSyscall(SYS_UMASK, uintptr(mask), 0, 0)\n\toldmask = int(r0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Uname(buf *Utsname) (err error) {\n\t_, _, e1 := RawSyscall(SYS_UNAME, uintptr(unsafe.",
"Pointer(buf)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Unmount(target string, flags int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(target)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_UMOUNT2, uintptr(unsafe.",
"Pointer(_p0)), uintptr(flags), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Unshare(flags int) (err error) {\n\t_, _, e1 := Syscall(SYS_UNSHARE, uintptr(flags), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Ustat(dev int, ubuf *Ustat_t) (err error) {\n\t_, _, e1 := Syscall(SYS_USTAT, uintptr(dev), uintptr(unsafe.",
"Pointer(ubuf)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc write(fd int, p []byte) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(p) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&p[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall(SYS_WRITE, uintptr(fd), uintptr(_p0), uintptr(len(p)))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc exitThread(code int) (err error) {\n\t_, _, e1 := Syscall(SYS_EXIT, uintptr(code), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc readlen(fd int, p *byte, np int) (n int, err error) {\n\tr0, _, e1 := Syscall(SYS_READ, uintptr(fd), uintptr(unsafe.",
"Pointer(p)), uintptr(np))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc writelen(fd int, p *byte, np int) (n int, err error) {\n\tr0, _, e1 := Syscall(SYS_WRITE, uintptr(fd), uintptr(unsafe.",
"Pointer(p)), uintptr(np))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc munmap(addr uintptr, length uintptr) (err error) {\n\t_, _, e1 := Syscall(SYS_MUNMAP, uintptr(addr), uintptr(length), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Madvise(b []byte, advice int) (err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(b) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&b[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall(SYS_MADVISE, uintptr(_p0), uintptr(len(b)), uintptr(advice))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Mprotect(b []byte, prot int) (err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(b) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&b[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall(SYS_MPROTECT, uintptr(_p0), uintptr(len(b)), uintptr(prot))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Mlock(b []byte) (err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(b) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&b[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall(SYS_MLOCK, uintptr(_p0), uintptr(len(b)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Mlockall(flags int) (err error) {\n\t_, _, e1 := Syscall(SYS_MLOCKALL, uintptr(flags), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Msync(b []byte, flags int) (err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(b) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&b[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall(SYS_MSYNC, uintptr(_p0), uintptr(len(b)), uintptr(flags))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Munlock(b []byte) (err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(b) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&b[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall(SYS_MUNLOCK, uintptr(_p0), uintptr(len(b)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Munlockall() (err error) {\n\t_, _, e1 := Syscall(SYS_MUNLOCKALL, 0, 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc pipe2(p *[2]_C_int, flags int) (err error) {\n\t_, _, e1 := RawSyscall(SYS_PIPE2, uintptr(unsafe.",
"Pointer(p)), uintptr(flags), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc accept(s int, rsa *RawSockaddrAny, addrlen *_Socklen) (fd int, err error) {\n\tr0, _, e1 := Syscall(SYS_ACCEPT, uintptr(s), uintptr(unsafe.",
"Pointer(rsa)), uintptr(unsafe.",
"Pointer(addrlen)))\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc accept4(s int, rsa *RawSockaddrAny, addrlen *_Socklen, flags int) (fd int, err error) {\n\tr0, _, e1 := Syscall6(SYS_ACCEPT4, uintptr(s), uintptr(unsafe.",
"Pointer(rsa)), uintptr(unsafe.",
"Pointer(addrlen)), uintptr(flags), 0, 0)\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc bind(s int, addr unsafe.",
"Pointer, addrlen _Socklen) (err error) {\n\t_, _, e1 := Syscall(SYS_BIND, uintptr(s), uintptr(addr), uintptr(addrlen))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc connect(s int, addr unsafe.",
"Pointer, addrlen _Socklen) (err error) {\n\t_, _, e1 := Syscall(SYS_CONNECT, uintptr(s), uintptr(addr), uintptr(addrlen))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc getgroups(n int, list *_Gid_t) (nn int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_GETGROUPS32, uintptr(n), uintptr(unsafe.",
"Pointer(list)), 0)\n\tnn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc setgroups(n int, list *_Gid_t) (err error) {\n\t_, _, e1 := RawSyscall(SYS_SETGROUPS32, uintptr(n), uintptr(unsafe.",
"Pointer(list)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc getsockopt(s int, level int, name int, val unsafe.",
"Pointer, vallen *_Socklen) (err error) {\n\t_, _, e1 := Syscall6(SYS_GETSOCKOPT, uintptr(s), uintptr(level), uintptr(name), uintptr(val), uintptr(unsafe.",
"Pointer(vallen)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc setsockopt(s int, level int, name int, val unsafe.",
"Pointer, vallen uintptr) (err error) {\n\t_, _, e1 := Syscall6(SYS_SETSOCKOPT, uintptr(s), uintptr(level), uintptr(name), uintptr(val), uintptr(vallen), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc socket(domain int, typ int, proto int) (fd int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_SOCKET, uintptr(domain), uintptr(typ), uintptr(proto))\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc getpeername(fd int, rsa *RawSockaddrAny, addrlen *_Socklen) (err error) {\n\t_, _, e1 := RawSyscall(SYS_GETPEERNAME, uintptr(fd), uintptr(unsafe.",
"Pointer(rsa)), uintptr(unsafe.",
"Pointer(addrlen)))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc getsockname(fd int, rsa *RawSockaddrAny, addrlen *_Socklen) (err error) {\n\t_, _, e1 := RawSyscall(SYS_GETSOCKNAME, uintptr(fd), uintptr(unsafe.",
"Pointer(rsa)), uintptr(unsafe.",
"Pointer(addrlen)))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc recvfrom(fd int, p []byte, flags int, from *RawSockaddrAny, fromlen *_Socklen) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(p) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&p[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_RECVFROM, uintptr(fd), uintptr(_p0), uintptr(len(p)), uintptr(flags), uintptr(unsafe.",
"Pointer(from)), uintptr(unsafe.",
"Pointer(fromlen)))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc sendto(s int, buf []byte, flags int, to unsafe.",
"Pointer, addrlen _Socklen) (err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(buf) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&buf[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\t_, _, e1 := Syscall6(SYS_SENDTO, uintptr(s), uintptr(_p0), uintptr(len(buf)), uintptr(flags), uintptr(to), uintptr(addrlen))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc socketpair(domain int, typ int, flags int, fd *[2]int32) (err error) {\n\t_, _, e1 := RawSyscall6(SYS_SOCKETPAIR, uintptr(domain), uintptr(typ), uintptr(flags), uintptr(unsafe.",
"Pointer(fd)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc recvmsg(s int, msg *Msghdr, flags int) (n int, err error) {\n\tr0, _, e1 := Syscall(SYS_RECVMSG, uintptr(s), uintptr(unsafe.",
"Pointer(msg)), uintptr(flags))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc sendmsg(s int, msg *Msghdr, flags int) (n int, err error) {\n\tr0, _, e1 := Syscall(SYS_SENDMSG, uintptr(s), uintptr(unsafe.",
"Pointer(msg)), uintptr(flags))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Dup2(oldfd int, newfd int) (err error) {\n\t_, _, e1 := Syscall(SYS_DUP2, uintptr(oldfd), uintptr(newfd), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Fchown(fd int, uid int, gid int) (err error) {\n\t_, _, e1 := Syscall(SYS_FCHOWN32, uintptr(fd), uintptr(uid), uintptr(gid))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Fstat(fd int, stat *Stat_t) (err error) {\n\t_, _, e1 := Syscall(SYS_FSTAT64, uintptr(fd), uintptr(unsafe.",
"Pointer(stat)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getegid() (egid int) {\n\tr0, _, _ := RawSyscall(SYS_GETEGID32, 0, 0, 0)\n\tegid = int(r0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Geteuid() (euid int) {\n\tr0, _, _ := RawSyscall(SYS_GETEUID32, 0, 0, 0)\n\teuid = int(r0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getgid() (gid int) {\n\tr0, _, _ := RawSyscall(SYS_GETGID32, 0, 0, 0)\n\tgid = int(r0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Getuid() (uid int) {\n\tr0, _, _ := RawSyscall(SYS_GETUID32, 0, 0, 0)\n\tuid = int(r0)\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc InotifyInit() (fd int, err error) {\n\tr0, _, e1 := RawSyscall(SYS_INOTIFY_INIT, 0, 0, 0)\n\tfd = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Lchown(path string, uid int, gid int) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_LCHOWN32, uintptr(unsafe.",
"Pointer(_p0)), uintptr(uid), uintptr(gid))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Listen(s int, n int) (err error) {\n\t_, _, e1 := Syscall(SYS_LISTEN, uintptr(s), uintptr(n), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Lstat(path string, stat *Stat_t) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_LSTAT64, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(stat)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc sendfile(outfd int, infd int, offset *int64, count int) (written int, err error) {\n\tr0, _, e1 := Syscall6(SYS_SENDFILE64, uintptr(outfd), uintptr(infd), uintptr(unsafe.",
"Pointer(offset)), uintptr(count), 0, 0)\n\twritten = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Select(nfd int, r *FdSet, w *FdSet, e *FdSet, timeout *Timeval) (n int, err error) {\n\tr0, _, e1 := Syscall6(SYS__NEWSELECT, uintptr(nfd), uintptr(unsafe.",
"Pointer(r)), uintptr(unsafe.",
"Pointer(w)), uintptr(unsafe.",
"Pointer(e)), uintptr(unsafe.",
"Pointer(timeout)), 0)\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setfsgid(gid int) (err error) {\n\t_, _, e1 := Syscall(SYS_SETFSGID32, uintptr(gid), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setfsuid(uid int) (err error) {\n\t_, _, e1 := Syscall(SYS_SETFSUID32, uintptr(uid), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setregid(rgid int, egid int) (err error) {\n\t_, _, e1 := RawSyscall(SYS_SETREGID32, uintptr(rgid), uintptr(egid), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setresgid(rgid int, egid int, sgid int) (err error) {\n\t_, _, e1 := RawSyscall(SYS_SETRESGID32, uintptr(rgid), uintptr(egid), uintptr(sgid))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setresuid(ruid int, euid int, suid int) (err error) {\n\t_, _, e1 := RawSyscall(SYS_SETRESUID32, uintptr(ruid), uintptr(euid), uintptr(suid))\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Setreuid(ruid int, euid int) (err error) {\n\t_, _, e1 := RawSyscall(SYS_SETREUID32, uintptr(ruid), uintptr(euid), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Shutdown(fd int, how int) (err error) {\n\t_, _, e1 := Syscall(SYS_SHUTDOWN, uintptr(fd), uintptr(how), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Splice(rfd int, roff *int64, wfd int, woff *int64, len int, flags int) (n int, err error) {\n\tr0, _, e1 := Syscall6(SYS_SPLICE, uintptr(rfd), uintptr(unsafe.",
"Pointer(roff)), uintptr(wfd), uintptr(unsafe.",
"Pointer(woff)), uintptr(len), uintptr(flags))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Stat(path string, stat *Stat_t) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall(SYS_STAT64, uintptr(unsafe.",
"Pointer(_p0)), uintptr(unsafe.",
"Pointer(stat)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Gettimeofday(tv *Timeval) (err error) {\n\t_, _, e1 := RawSyscall(SYS_GETTIMEOFDAY, uintptr(unsafe.",
"Pointer(tv)), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc EpollWait(epfd int, events []EpollEvent, msec int) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(events) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&events[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_EPOLL_WAIT, uintptr(epfd), uintptr(_p0), uintptr(len(events)), uintptr(msec), 0, 0)\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Pause() (err error) {\n\t_, _, e1 := Syscall(SYS_PAUSE, 0, 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Pread(fd int, p []byte, offset int64) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(p) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&p[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_PREAD64, uintptr(fd), uintptr(_p0), uintptr(len(p)), 0, uintptr(offset), uintptr(offset>>32))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Pwrite(fd int, p []byte, offset int64) (n int, err error) {\n\tvar _p0 unsafe.",
"Pointer\n\tif len(p) > 0 {\n\t\t_p0 = unsafe.",
"Pointer(&p[0])\n\t} else {\n\t\t_p0 = unsafe.",
"Pointer(&_zero)\n\t}\n\tr0, _, e1 := Syscall6(SYS_PWRITE64, uintptr(fd), uintptr(_p0), uintptr(len(p)), 0, uintptr(offset), uintptr(offset>>32))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Truncate(path string, length int64) (err error) {\n\tvar _p0 *byte\n\t_p0, err = BytePtrFromString(path)\n\tif err !",
"= nil {\n\t\treturn\n\t}\n\t_, _, e1 := Syscall6(SYS_TRUNCATE64, uintptr(unsafe.",
"Pointer(_p0)), 0, uintptr(length), uintptr(length>>32), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc Ftruncate(fd int, length int64) (err error) {\n\t_, _, e1 := Syscall6(SYS_FTRUNCATE64, uintptr(fd), 0, uintptr(length), uintptr(length>>32), 0, 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc mmap2(addr uintptr, length uintptr, prot int, flags int, fd int, pageOffset uintptr) (xaddr uintptr, err error) {\n\tr0, _, e1 := Syscall6(SYS_MMAP2, uintptr(addr), uintptr(length), uintptr(prot), uintptr(flags), uintptr(fd), uintptr(pageOffset))\n\txaddr = uintptr(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc getrlimit(resource int, rlim *rlimit32) (err error) {\n\t_, _, e1 := RawSyscall(SYS_UGETRLIMIT, uintptr(resource), uintptr(unsafe.",
"Pointer(rlim)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc setrlimit(resource int, rlim *rlimit32) (err error) {\n\t_, _, e1 := RawSyscall(SYS_SETRLIMIT, uintptr(resource), uintptr(unsafe.",
"Pointer(rlim)), 0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n\n// THIS FILE IS GENERATED BY THE COMMAND AT THE TOP; DO NOT EDIT\n\nfunc poll(fds *PollFd, nfds int, timeout int) (n int, err error) {\n\tr0, _, e1 := Syscall(SYS_POLL, uintptr(unsafe.",
"Pointer(fds)), uintptr(nfds), uintptr(timeout))\n\tn = int(r0)\n\tif e1 !",
"= 0 {\n\t\terr = errnoErr(e1)\n\t}\n\treturn\n}\n"
] | {
"pile_set_name": "Github"
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[
"1. ",
"Field of the Invention\nThis invention relates to a suspension system for an attraction type magnetically floated travelling body.",
"\n2. ",
"Description of the Prior Art\nAn attraction type magnetically floated travelling body is arranged to be floated in the air by attraction forces of electromagnets exerted on rails and then is caused to travel by a propelling means such as a linear motor with a floating gap of about 10 mm maintained along the rails. ",
"The floating gap is extremely small.",
"\nThis means that, where the travelling body is arranged to travel at a high speed of 70 to 80 meters/sec. ",
"or thereabout, thorough consideration is required for maintaining the above stated amount of gap unvaried. ",
"There has previously been developed an independent suspension system in which electromagnets are attached to a travelling body through a secondary suspension arrangement. ",
"In this system, many electromagnets to be attached to the travelling body are divided into a number of groups. ",
"Each group is firmly assembled into an independent module (or an assembled unit structural body) independently of other groups and the module is attached to the travelling body through the secondary suspension arrangement. ",
"Compared with the so-called fixed suspension system, the module arrangement makes each of the modules mobile independently of the travelling body and imparts an improved capability for following the rail to each electromagnet to lower the degree of dependency upon the precision required in laying the rails, i.e. precision in carrying out the laying, maintenance and inspection work on the rails is required to a less degree. ",
"Besides, with this system employed, the travelling body becomes more comfortable to ride on, because the movement of the electromagnets, such as vibration of the electromagnets in following warped parts of the rails, is not directly transmitted to the travelling body. ",
"The present invention is directed to an improvement on this suspension system."
] | {
"pile_set_name": "USPTO Backgrounds"
} | [
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[
"[The use of titanium mesh plates for graft fixation in mandibular osteoplasty].",
"\nOpportunities of the use of mesh titanium plates as fixing devices are considered at reconstruction operations. ",
"Data of following up 8 patients with defects of the mandible of various location and extent are analysed. ",
"They were operated with reconstruction of the mandible with iliac graft and bone graft fixing with the mesh titanium plates. ",
"A technique of the operations is described, a case of successful use of mesh titanium implant modelled by the form of the mandible in repair of the mandible defect. ",
"The analysis of long-term results shows the potential efficiency of the use of mesh titanium plates as fixing adaptations in bone plastic operations."
] | {
"pile_set_name": "PubMed Abstracts"
} | [
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] | 0.000817 | 6 |
[
"Q:\n\nHow can I redirect to a particular view based on url in grails\n\nI am using grails 2.5.5 version, Suppose I am entering url as www.localhost:8080/app-name then it should open the MyHome.gsp, suppose if I give other url ex: demo1.localhost.com:8080/app-name then it should redirect to some login page like login.jsp. ",
"How can I do that?",
"\n\nA:\n\nLet me break it up for you :\nSuppose I have www.localhost:8080/app-name \nsuppose if I give other url ex: demo1.localhost.com:8080/app-name\nYour app starts here:\nCase 1 :/app-name\ncase 2 :/app-name\nThe rest of that url is actually DNS and configurating binding tomcat specific or wild card urls to a given application.",
"\nSo in short you need to filter entire url in the application parse url and redirect in your app accordingly. ",
"\nYou need to then intercept every url with grails 2 there is SecurityFilters which so far as i know works with apache-shiro may also work with spring security.",
"\nand within it you need to overall check for something like\nURL url = new URL(request.getRequestURL().toString())\n String subdomain=url.host\n if (subdomain.contains('.')) {",
"\n subdomain= subdomain.split('.",
"')[0]\n }\nthat then returns your `demo1` you then redirect it another url if it matches your specific rule.",
"\n\nBut as I said you are talking about superficial stuff here as I expressed what the address is or how somone gets to the app has nothing to do with the actual application. ",
"This is why IT is big business. ",
"Big business not because everyone tries to narrow everything down into one box doing all of this but because when situations likes this happen bigger thinking is needed i.e. do i need a load balancer something like F5 that will split traffic according to a given url and send to another app container that asks for authorisation.",
"\nsubdomain= subdomain.split('.",
"')[1] in that case then but this leaves room for errors since user could put in demo1.somedomain.com and if that resolves well it is either split by subdomain= subdomain.split('.",
"')[0] \nI would do this then \nString subdomain=url.host\n\n if (subdomain.contains('.')) {",
"\n def splitter= subdomain.split('.')",
"\n subdomain= splitter[0]\n if (subdomain=='www' && splitter.size()>1) {\n subdomain= splitter[1] \n }\n }\n\n"
] | {
"pile_set_name": "StackExchange"
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[
"Nearly half of American men have a genital human papillomavirus (HPV) infection, but a much smaller percentage have received the HPV vaccine, according to a new study.",
"\n\nThe results show that about 45 percent of U.S. men under age 60 have a genital HPV infection, which translates to about 35 million men, the researchers said. ",
"What's more, 25 percent of men were infected with so-called \"high-risk\" types of HPV, which, compared with low-risk types of HPV, are more strongly linked with cancer. ",
"Only about 11 percent of U.S. men had received the HPV vaccine, according to the study, published today (Jan. 19) in the journal JAMA Oncology.",
"\n\nAnd surprisingly, the researchers found a high rate of HPV infection in older men. ",
"In fact, the highest rate of HPV infection seen in the study was among those ages 58 to 59 (the oldest age group in the study). ",
"This higher rate of HPV infection in older men contrasts with what's been seen in women: The HPV infection rate is lower in older in woman than in younger ones. [",
"Men vs. Women: Our Key Physical Differences Explained]\n\nThe \"consistent, high infection rate among all age groups in men was very striking, because this was not expected,\" said Dr. Jasmine Han, who led study and is the chief of gynecologic oncology at the Womack Army Medical Center in Fort Bragg, North Carolina.",
"\n\nThe study is the first to estimate the percentage of U.S. men that have a genital HPV infection.",
"\n\nThe researchers hope the findings will increase public awareness of the current low HPV vaccination rate and the high HPV prevalence rate, Han told Live Science. ",
"HPV-associated cancers in men are increasing, she noted. ",
"There is a very effective \"vaccine that could eradicate HPV-associated cancers in both women and men, but the prevalence remains high despite the availability\" of these vaccines, she said.",
"\n\nThe current vaccination age cutoff for men, 26, should be re-evaluated in light of the new findings showing a widespread high HPV prevalence rate among all age groups, Han said.",
"\n\nHPV in men\n\nHuman papillomaviruses are a group of more than 150 related viruses that infect different parts of the body. ",
"HPVs that infect the genital area can spread as sexually transmitted infections. ",
"Most infections go away on their own, but some can linger and lead to health problems, including genital warts and cancer, according to the Centers for Disease Control and Prevention.",
"\n\nIn the past, efforts to prevent HPV infection focused mainly on women, because HPV infections can lead to cervical cancer. ",
"But in 2009, health officials approved the HPV vaccine for males, and the vaccine is now recommended for both females and males ages 11 to 26 years old.",
"\n\nHowever, few studies have looked at the prevalence of genital HPV infection in men, or how many men receive the HPV vaccine.",
"\n\nIn the new study, researchers analyzed information from 1,868 men ages 18 to 59, who took part in a national health survey from 2013 to 2014. ",
"In addition to answering questions, the men in the study underwent a physical exam. ",
"As part of that exam, the participants swabbed their penises. ",
"The samples were then tested for DNA from nearly 40 different types of HPV.",
"\n\nMen in the youngest age group, ages 18 to 22, had the lowest rate of infection, with about 29 percent of men in this group having an HPV infection. ",
"But the rate of HPV infection was higher, 46.5 percent, among men ages 23 to 27, and it reached 51 percent among men ages 28 to 32.",
"\n\nAmong men in their late 30s and early 40s, the rate of HPV infection was slightly lower, but among men ages 58 and 59, the rate was nearly 60 percent, the study found.",
"\n\nIn contrast, a 2011 study of HPV infections in women found that the rate of HPV infection was nearly 54 percent among 20- to 24-year-olds, but only 39 percent among 50- to 59-year-olds.",
"\n\nVaccinate older men?",
"\n\nThe finding of a lower rate of HPV infection in younger men compared with older ones may, in part, reflect the current recommendation to give the HPV vaccine to younger men. ",
"Among men ages 18 to 22 in the study, 22 percent had received the HPV vaccine.",
"\n\nIn addition, some studies suggest that men's immune systems don't respond as strongly to fight off HPV infections as women's systems do. ",
"What's more, people's immune systems decline with age, which may be why the older men in the study had accumulated a higher rate of infections than the younger group, Han speculated.",
"\n\nFinally, some studies have found that men tend to have a similar number of new and recent sexual partners, regardless of their age, which provides continued opportunity for HPV infection throughout their lives, the researchers said.",
"\n\nBecause the study was conducted at a single point in time, it cannot determine why older men had higher rates of HPV infection, the researchers noted. ",
"The study also cannot determine the effect of the HPV vaccine on the risk of infection among different age groups. [",
"5 Dangerous Vaccination Myths]\n\nStill, the researchers estimated that more than 25 million American men are eligible for the HPV vaccine, but haven't received it. ",
"HPV vaccination \"may have a profound effect on the prevention of HPV-related cancers\" in both men and women, because men serve as reservoirs for HPV infections for women and because HPV can also cause genital and oral cancers in men, the researchers said.",
"\n\nAdditional reporting by Karen Rowan.",
"\n\nOriginal article on Live Science."
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"\n965 A.2d 294 (2008)\nCOM.",
"\nv.\nHARSHBERGER.",
"\nNo. ",
"2136 WDA 2007.",
"\nSuperior Court of Pennsylvania.",
"\nDecember 9, 2008.",
"\nAffirmed.",
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"Tips For Test Driving At The Auto Dealership In Alexandria\n\nAny buyer should know just how useful a test drive can be for selecting the right vehicle at a great value. ",
"However, there are some consumers that are not quite sure how to make sure that they are getting the best of the best in terms of a used car. ",
"These are some good test driving techniques that can really assist you with the process and open you up to a world of possibilities for your buying experience.",
"\n\nSet Benchmarks\n\nWhen you are in the initial shopping phase, you need to know what you are interested in buying. ",
"Jot down some of the must-have elements for buying a vehicle so that you can check all the boxes when you arrive at the dealership. ",
"When you have standards that the vehicle needs to uphold, it will be easier for you to cut out those that simply do not work so that you are not wasting your time on any vehicle that does not have a chance.",
"\n\nTest Drive Whatever You Can\n\nBelieve it or not, there could be many buying options out there that you may not have even given much of a thought. ",
"The more vehicles that you test drive, the more you are opening yourself up to something unexpected that you could fall in love with. ",
"If there is a vehicle you would normally shy away from, it will not hurt to get behind the wheel to see how it handles. ",
"There could be a hidden gem or two at the used car dealership that will wow you and makes you a believer.",
"\n\nNever Be Afraid To Take Notes\n\nIf there are several vehicles that you enjoyed test driving, it will always benefit you to have some side by side comparisons to help you with making your decision. ",
"Take notes on whatever elements you liked or disliked about each option so that you have something to look back on to narrow down your list.",
"\n\nTake Your Time\n\nWhile you may feel as though you should be driving away from the dealership in a new to you vehicle on the very same day that you test drive, this is never something you should rush. ",
"Take the time to weigh your options, run the numbers, and work with the dealership staff so that you can get the warranties and pricing that you need to make the buying experience worthwhile.",
"\n\nWorking with Expert Auto will always give you the selection and pricing that you need to get behind the wheel of a great used vehicle. ",
"We will work with you and help you with the test drive process so that you can find exactly what meets up with your driving personality, buying requirements, and your budget."
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"SEC to revive rule requiring CEO disclosure of pay gap\n\nThursday, 22 Aug 2013 | 9:34 AM ETCNBC.com\n\nSHARES\n\nSteve Cole | Photodic | Getty Images\n\nThe Securities and Exchange Commission is close to reviving a rule that requires companies to be transparent about how much more CEOs make than their rank-and-file, The Wall Street Journal reported on Thursday.",
"\n\nThe SEC's move was tucked within the framework of the 2010 Dodd-Frank financial reform bill, which continues to attract controversy because of its provisions. ",
"The rule is expected to be approved by the SEC as early as September, sources tell the WSJ, but is expected to be less cumbersome than what lawmakers originally envisioned.",
"\n\nThe regulatory body is expected to allow companies to consider a fraction of their employees when calculating median pay, the newspaper reported. ",
"Companies would have to disclose the ratio between CEO compensation and the median pay of the sampled employee group, it added."
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[
"Welcome to A+ Agents of Process, Inc.\n\nAll truckers for hire, brokers, or freight forwarders must file a BOC-3 (Process Agents) form with the Federal Motor Carrier Safety Administration (FMCSA) BEFORE their Authority will be issued.",
"\n\nWhat is form BOC-3 (Process Agents)?",
"\n\nA Form BOC-3 designates a person or an office to accept any legal papers on your behalf in any state you conduct business and/or traverse through, and then forward them to you\n\nIF THERE IS NO FORM BOC-3 OR NO INSURANCE ON FILE WITH THE FMCSA, THERE WILL BE NO AUTHORITY ISSUED."
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