Patent Application: US-47654406-A

Abstract:
formulas for producing compositions for the dietary supplement and nutraceutical products , containing virgin olive oil , vitamins , substances as vincamine , vinpocetine or vinburnine , as well as herbal extracts from vinca minor and crioceras longiflorus . the present invention also relates to the oral administration of these compounds , to alleviate mental fatigue or poor cognitive function and anti - ageing prevention .

Description:
the following specification sets forth the preferred embodiments of the present invention . the embodiments of the invention disclosed herein are the best modes contemplated by the inventors for carrying out their invention in a commercial environment , although it should be understood that various modifications can be accomplished within the parameters of the present invention . the present invention provides a series of simple nutritional supplements to improve and maintain memory , and increase longevity . components of the composition : the composition of this invention consists fundamentally of the following ingredients : virgin olive oil , vitamin b2 ( riboflavin ), vitamin e ( tocopherol ) and extracts of vinca minor , or crioceras longiflorus , or vincamine ( natural origin ), or vinburnine ( natural origin ), or vinpocetine ( natural origin ) in soft gelatine capsules : vitamins : vitamin b2 ( riboflavin ) acts as coenzyme on metabolism of carbohydrates , lipids and proteins . it is essential for cellular energy needs . vitamin e ( tocopherol ) is a fat - soluble antioxidant that plays numerous protectant and physiological roles in the cellular metabolism and is the most effective chain - breaking antioxidant within the cell membrane where it protects membrane fatty acids from lipid peroxidation . the compositions contain preferably from 5 mg to 7 mg of those vitamins . virgin olive oil : is the principal ( often exclusive ) and most typical source of visible fat of the mediterranean diet . the healthful properties of olive oil have been often attributed to its high monounsaturated fatty acid ( mfa ) content , namely in the form of oleic acid ( 18 : ln - 9 ). however , olive oil poliphenols at nutritionally relevant concentrations transcriptional inhibit endothelial adhesion molecule expression . the latest studies strongly suggest that dietary polyphenols can stimulate antioxidant transcription and detoxification defence systems through antioxidant responsible elements . these compositions contain preferably from about 140 mg to 160 mg of olive oil . vinca minor extract : this is the common periwinkle , a herbaceous plant with trailing stems that occasionally root into the ground , bearing persistent , opposite , and tough leaves with shiny blades . it is used for circulatory disorders , cerebral circulatory impairment and support for the metabolism of the brain . it is also used for loss of memory , hypertension , cystitis , gastritis and enteritis , diarrhoea , high blood sugar levels and to help weaning . the compositions contain preferably from about 18 mg to 22 mg of vinca minor extract . crioceras longiflorus : it is a small bush or tree , belonging to the apocynaceae plant family . it grows in africa , more specifically in the central african region ; the c . longiflorus is a plant whose alkaloids opened a vast therapeutic field . the major alkaloid is the 17 , 18 - dehydrovincamine and its epimer 16 - epi - 17 , 18 dehydrovincamine . when these extracts are hydrogenated they give an extract that contains vincamine . the compositions contain preferably from about 5 mg to 10 mg of crioceras longiflourus extract . vincamine : is the major alkaloid present in the vinca minor extract . its use is recommended as a cerebral vasodilator in neo - natal calves , for cerebral anoxia . it is widely used in human medicine , to increase global and regional blood flow in patients suffering from acute or sub chronic cerebral ischemia . it occurs naturally in vinca minor leaves . the composition contains preferably from about 5 mg to 10 mg of vincamine . vinburnine : is an alkaloid related to vinca and other related species . activator of cerebral metabolism by enhancing blood flow . it has been studied in the treatment of cerebral insufficiency with cognitive dysfunction . it occurs naturally in the hunteria eburnea plant . the composition contains preferably from about 5 mg to 10 mg of vinburnine . vinpocetine : is a nootropic derived from plants . it has been shown to improve blood flow , circulation and oxygen utilization in the brain of animals and humans . it also protects neurons from the devastating effects of disrupted oxygen delivery . it is , therefore , a useful therapy for symptoms of senile dementia and cerebral vascular insufficiency . vinpocetine also improves energy production in brain cells . it has been studied as a memory booster for young , healthy people , in whom it has been shown to improve short - term memory . in addition , it appears to have anticonvulsant properties . a russian study of epileptic patients demonstrated that vinpocetine reduced the frequency and , in some cases , completely eliminated epileptic seizures in twenty of the thirty - one patients participating in the study . it occurs naturally in crioceras longiflorus root bark . the compositions contain preferably from about 1 mg to 2 mg of vinpocetine . formulation 1 : a soft capsule contains 3 mg of vitamin e , 3 mg of vitamin b2 , 150 mg of virgin olive oil , 20 mg of vinca minor extract and excipients . formulation 2 : a soft capsule contains 3 mg of vitamin e , 3 mg of vitamin b2 , 150 mg of virgin olive oil , 10 mg of crioceras longiflorus ( hydrogenated extract ) and excipients . formulation 3 : a soft capsule contains 3 mg of vitamin e , 3 mg of vitamin b2 , 150 mg of virgin olive oil , 10 mg of vincamine and excipients . formulation 4 : a soft capsule contains 3 mg of vitamin e , 3 mg of vitamin b2 , 150 mg of virgin olive oil , 10 mg of vinburnine and excipients . formulation 5 : a soft capsule contains 3 mg of vitamin e , 3 mg of vitamin b2 , 150 mg of virgin olive oil , 2 mg of vinpocetine and excipients . 3 .— guyton , a . c . textbook of medical physiology , 10th edition , wb . saunders co 2000 . 4 .— tucker , d . m . et al . “ nutrition status and brain function in aging ”. american journal of clinical nutrition , 52 ( 1 ): 92 - 102 , july 1990 . 5 .— la rue , a . et al . “ nutritional status and cognitive functioning in a normal aging sample : a 6 - year reassessment ”. american journal of clinical nutrition , 65 ( 1 ): 20 - 29 , january 1997 . 6 .— perez - jimenez , f . ; 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