Patent Application: US-50928100-A

Abstract:
the present invention concerns a composition containing a cholesterol lowering component such as β - sitosterol and / or β - sitostanol in a monomolecular , low associated or “ cluster ” form , where a melt and / or solution of the said components are distributed , immobilised and stabilised in a matrix ; food containing such a composition and a method of preparing this composition .

Description:
in the present invention we show how sterols and stanols by simple methods can be stabilised in monomolecular , low associated or “ cluster ” form by distributing and immobilising a solution of high concentration or a melt of sterols and / or stanols in a matrix . sterols and / or stanols are initially dissolved in an organic phase , for instance in mono , di - or triglycerides , fatty acids , lecithin and others preferentially at an elevated temperature . the solution is then mixed with a stabilising phase matrix , containing a high molecular material e . g ., gelatin , casein , starch syrup , pectin , ethylhydroxyethylcellulose or other at an elevated temperature . the mixture is then allowed to set to a solid , rubberlike or highly viscous mass . the stabilising phase can also be based on solvents being solid at room temperature . an alternative way to make the composition is to foam a solution of the sterols and / or stanols containing a solvent solid at room temperature possibly in the presence of a foam building component under rapid cooling . the surface of sterols and / or stanols accessible to the stomach thus becomes extremely large . foaming can be done in different known ways . some percent of ethanol can be added to the sterols and / or stanols , the mixture is melted at elevated temperatures , the alcohol evaporated in vacuo under formation of foam . the solutions described above can also be mixed into different food e . g . chocolate , dough / bread , jelly , mashed potatoes , butter / margarine , yougurt and others or be encapsulated or mixed into tablets . the special characteristics of the present innovation are also shown by the enclosed claims . the present innovation is described below by not limiting examples . if not otherwise stated the given values are in weight or weight %. 30 g of β - sitostanol were dissolved in 70 g of a monoglyceride such as dimodan rt oil at 90 ° c . on a hot water bath and stirred until the stanol was completely dissolved . the 30 % solution can be used directly or stored as a prefabricate after cooling as a homogenous mass . 20 g of the solution obtained were slowly added under intensive stirring to 80 g of a 35 % solution of gelatin and agar 10 : 1 , starch syrup , sugar and aroma in water placed on a hot water bath at 65 ° c . the liquid highly viscous composition was immediately cast in small forms , where it solidified as a gel containing β - sitostanol in a stabilised monomolecular or low associated form . the composition can be used as such or be mixed into food and / or be foamed , encapsulated or made into tablets . 10 g of β - sitostanol were dissolved in 10 g of dimodan rt at 120 ° c . on an oil bath . the solution was carefully under intensives stirring added to 80 g of a 30 % solution of gelatin in water , also containing sugar and aroma , placed on a water bath of 85 ° c . the homogenous stabilised composition was then treated as in example 1 . 10 g of β - sitosterol were dissolved in 10 g of rapeseed oil at 120 ° c . on an oil bath . the solution was carefully under intensive continous stirring added to 30 g of a 30 % solution of gelatin in water , containing sugar and aroma , placed on a hot water bath of 95 ° c . the homogenous stabilised composition was then treated as in example 1 . 10 g of β - sitostanol were dissolved in 10 g of rapeseed oil at 130 ° c . on an oil bath . the solution was carefully added under intensive continous stirring to 50 g of a 30 % solution of gelatin in water , containing sugar and aroma , placed on a hot oil bath of 110 ° c . the homogenized stabilized composition was then treated as in example 1 . 10 g of β - sitostanol were dissolved in 10 g of dimodan rt at 120 ° c . on an oil bath . in another flask 80 g , of chocolate mass were melted on the same bath . the 50 % solution of β - sitostanol was slowly added under continous stirring to the chocolate . the composition was directly cast in forms , where it solidified and could be used as such or mixed into food or tableted , encapsulated or foamed . 10 g of β - sitostanol were dissolved in 10 g of rapeseed oil at 130 ° c . on an oil bath . in another flask 40 g of chocolate mass were melted at 110 ° c . on an oil bath . the 50 % solution of β - sitostanol was added under continous stirring to the chocolate . the composition was directly cast in forms where it solidified and can be used as such or mixed into food or be tableted , encapsulated or foamed . 30 g of β - sitostanol were dissolved in 30 g stearic acid at 130 ° c . on an oil bath . a few drops of ethanol were added under intensive stirring and the composition was placed under vacuum . the mass bubbled up and was allowed to solidify as a foamed material that could be mixed in , for instance , flour , dough , mashed potatoes or other food material , encapsulated or tableted . alternatively the composition can be directly cooled and used as such , mixed into food , encapsulated or tableted . 2 . 5 g of β - sitosterol were dissolved in 2 . 5 g of 2 . 5 g of dimodan ml at 80 ° c . the solution was added to 1 liter of a 3 % solution of sodium caseinate at 60 - 80 ° c . under strong stirring with a turrax . after 5 minutes the emulsion was cooled to 20 ° c . and can be used as a beverage . the emulsion can be kept in a fridge during at least 3 days . the same result is obtained using milk . 12 . 5 g of β - sitosterol were dissolved in 25 g 2 . 5 g of dimodan ml at 60 ° c . the solution was added to 80 g of melted margarine and mixed with 125 g of flour , 175 g of oat flakes , 2 . 5 g of baking powder and 80 g of sugar to a dough . the mixture was baked into 25 cakes of 18 - 20 g each containing 0 . 5 g of β - sitosterol . 1 pollak , o . j ., reduction of blood cholesterol in man . cirkulation , 7 , 702 - 706 , ( 1953 ) 2 grundy , s . m ., ahrens , e . h . jr ., and davignon , j ., the interaction of cholesterol absorption and cholesterol synthesis in man . j . lipid res ., 10 , 304 ,( 1969 ). 3 farguhar , j . w . and sokolow , m ., response of serum lipids and lipoproteins of man to beta - sitosterol and sanflower oil — a long term study , cirkulation , 17 , 890 ,( 1956 ). 4 oster , p ., schlierf , g ., heuck , c . c ., greten , h ., gundert - 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700 , ( 1982 ). 20 a substance for lowering high cholesterol level in serum and method for preparing the same . patent c07j 9 / 00 , a61k31 / 575 .