Patent Application: US-201415314239-A

Abstract:
the present invention relates in general to a medical device consisting of a blocker made of a mixture of natural products such as african palm oil and the triglycerides thereof and natural waxes as active and emulsifying components , polymer and silver nanoparticles , acting as a blocker for latex protein and other skin irritants .

Description:
the present invention consists of an emulsion made with silver nanoparticles which functions as a latex protein and other skin irritants blocker . the blocking process is based on the behavior of a solution based on the interface that is affected by the surface charge , dipoles , energies , and their distribution within the double electric layer . the contact zones between the different states of matter or phases where a set of atoms , small in quantity of species in comparison with the total of atoms and molecules that constitutes the phases , interacts while forming chemical bonds . for example , several processes take place on surfaces , among which we can mention : electrochemical reactions , colloidal systems , detergency and flotation , biological membranes , lubrication , corrosion , heterogeneous catalysis , etc . the invention uses microfilm technology and refers to an application of surface chemistry with the final modification or protection of a surface where a microfilm is generated with the bonding of chemical bonds between the polymers , the treacylglycerides generating a microfilm . this invention is an emulsion based on silver nanoparticles , very effective for blocking latex protein and other skin irritants and thereby preventing it from contacting and affecting the skin by producing a kind of invisible glove . this device allows the use of the properties of silver as a protective barrier that blocks the latex protein , being an antibacterial protective barrier for people working with their hands on risk surfaces such as patients &# 39 ; skin , food or money , thereby maximizing - the properties of silver to cure recurrent skin diseases and avoiding bacterial contact . it is an aqueous suspension of lipids with a high degree of saturation that has a protective waxing effect , where alkali salts of the fatty acids associated with methylvinylether copolymer and silver nanoparticles generate an impenetrable film . the mixture of the alkali salts of the fatty acids present in these lipids blocks the penetration of irritants such as latex protein or irritants . it is a product intended to solve the number one problem of the latex glove industry that is the cutaneous allergic reaction caused by the latex protein . there is a precedent in costa rica , widely publicized in the press , in which the constitutional chamber through sentence no . 2003 - 1432 ( 4 ) forced the costa rican social security fund to indemnify and provide a solution to a surgeon with a known sensitivity to latex . at that time , the only solution that the social security could offer is the supply of gloves of another material in spite of being more expensive and difficult to obtain . this invention is a biotechnological solution , through the application of surface chemistry and microfilm technology , made with natural products from our land ( one of which is a waste of the costa rican industry ). the formula is applied to the skin , producing a barrier that prevents proteins in the latex from reaching or affecting the skin . the reason and basis that led to the preparation of this invention is the risk of developing allergy to latex , by all those users , continuously exposed to this allergen , due to their type of work . many of these workers are unable to carry out their work since they are inevitably no longer able to use this type of gloves . for these reasons , this invention is a solution that solves this problem . thanks to its formulation , a mixture of natural products provided by triglycerides as active component , natural waxes and emulsifiers , forms a microfilm on the epidermis , blocking by interaction the transfer of proteins from the latex to the skin , and prevents the development of allergy : without any effect on the dermis and all its usefulness is applicable to this allergen . it is also non - toxic and does not pollute ecosystems . in addition to its use to prevent the development of latex allergy , the invention may block the action of irritants on the skin , such as chemicals , for example formalin , xylol , cement , or household substances such as dishwashing soaps . the product is born in nanotechnology and is especially effective due to its - particle size that will allow better results unlike what exists in the state of the art . ionic silver , when near a virus , fungi , bacteria or any other unicellular organism , neutralizes the enzymes that they use to metabolize the oxygen , at the same time that they alter the permeability of the membrane of the unicellular organism . in a few minutes , these organisms are effectively asphyxiated . it is also known that ionic silver does not act on the cells of the host , as the enzymes are radically different from those of unicellular organisms . similarly , silver acts as a neutralizer of the latex protein , creating a barrier that protects the skin . it is the only product on the world market that solves the allergy produced by latex - gloves . it is a white suspension , consisting of natural products such as vegetable oils , fatty acids from vegetable oils , essential oils , emulsifiers and thickeners . especially manufactured to block the antigens contained in latex products , especially those of the latex glove , so that it does not reach the wearer &# 39 ; s skin , while moisturizing the skin and allowing it to heal through its own natural processes . most allergies - will heal in 4 days and more sensitization will be prevented , as long as the user continues to block allergens with the present invention . the invention thus blocks the direct contact of the latex materials [ gloves , etc .] with the skin and therefore eliminates the inherent adverse allergic effect of the latex protein . it directly controls latex allergies , both type 1 and type 4 , is 100 % effective , prevents users [ not yet sensitized ] from any future sensitization and avoids problems of workforce disabilities due to the dreaded latex allergy . it is a product that uses microfilm technology and surface chemistry . it is 100 % safe as a result of a formulation that consists of natural active ingredients and presents a moisturizing and breathable barrier that promotes optimal natural conditions to accelerate healing , has no known side effects , fast acting allergies to latex type 1 are resolved within a week and the microfilm technology , with which the present invention is formulated , enables close monitoring of the skin contours . it is the only one of its kind , which allows glove users to cope with latex allergies and has additional benefits because it protects users from the effects of harsh chemicals on the skin . 2 . materials section . the materials used in the composition are as follows : asian palm oil . parafan , mixtures of vegetable fatty acids of vegetal origin , produced as a result of its process of manufacture and the purification of african palm oil . industrial grade sodium hydroxide . industrial grade sodium benzoate . gantrez an 139 . triton x 100 whose active component is nonyl phenol ethoxylate , which is used in the product as an emulsifier . water . deionized water triethanolamine : industrial grade amine . astek eucalyptus , code p0150 or similar . silver nanoparticles in deionized water . ( ag ). these silver nanoparticles are low concentrations suspended in distilled water and produced by electric methods from silver electrodes having an atomic mass of 107 . 868 g / mol , melting point of 960 . 5 ° c ., boiling point of 2000 ° c . and density at 15 ° c . of 10 . 49 g / ml . it is not attacked by water or atmospheric oxygen ; it is obscured by ozone and hydrogen sulfide . it is inert to many acids , reacts easily with diluted nitric acid and hot sulfuric acid . it is not sensitive to light in metallic form . generator of silver nanoparticles . the generator used is a robey device which uses a voltage source of 110 - 115 v and comprises a current controller and produces silver nanoparticles in line . it comprises two silver electrodes , placed in a compartment , and a cellulose filter which restricts the passage of large particles of silver , letting through nanoparticles between 60 and 140 nm . preparation of the stock solution : 5 . 10 kg of parafan are placed in a 150 l stainless steel vessel and heated until they are melted and 1 l of a sodium hydroxide solution containing 350 g of naoh per liter is added slowly , then mixed until the parafan is dissolved . 5 . 45 kg of african palm oil are added to this vessel , stirred and 420 g of triton x - 100 and 420 g of - triethanolamine are then added . water is added to make up to 100 l of solution and stirred to form a homogeneous white suspension and then 60 g of sodium benzoate is added , stirring until complete dissolution is achieved . commercial solution : 87 . 2 l of water with silver nanoparticles are placed in a 150 l vessel and 10 l of stock solution is added under stirring and the mixture is stirred for 5 minutes and then 1 . 0 kg of gantrez an - 139 , which was prepolymerized in a stainless steel vessel containing 1 l of deionized water at 40 ° c . is added , and continuous stirring is applied until the product becomes clear and viscous . 500 ml of eucalyptus oil is added to this solution under stirring . physico - chemical specifications . the physico - chemical specifications of the product are as follows : palm oil . this oil is characterized by a high content of short chain fatty acids of 12 carbons or less . it has a relatively low and marked melting point , and is quite hard and fragile at lower temperatures . because palm kernel oil has a high content of c18 unsaturated acids , it can produce a broader range of products , after fractionation and / or hydrogenation . some physico - chemical properties are shown in the following table . soybean oil . soybean oil is widely used in the preparation of refined products , although not as much as palm oil . soybean oil has the characteristics shown in the following table . mechanism of action of the invention . the present invention provides a major part of the replacement of the physiological lipids that are reduced in the stratum corneum in patients with atopic dermatitis ( ad ). in addition , it replenished the skin with ceramide , a key lipid lacking in the corneal layer in patients with ad . the compound offers an optimal ratio of 3 : 1 : 1 ceramides , cholesterol and free fatty acids to help normalize the barrier function of the skin . the invention acts by forming a vapor permeable barrier which allows a metabolic response to repair the skin and helps to normalize the ph in the stratum corneum . this emulsion is readily reacted with diluted nitric acid and hot sulfuric acid ; 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