Patent Application: US-201415501129-A

Abstract:
the invention relates to a pharmaceutical composition consisting of snail slime of helix aspersa muller , chamomile extract , honey , and additives and / or pharmaceutically accepted excipients to form a formulation having low , intermediate or high viscosity . by dipping a patch or bandage of gauzy fabric into the composition in the form of a lotion , shampoo , soap , cream or gel , the composition is applied on lesions caused by psoriasis . the composition can also contain natural extracts , such as marigold extract , propolis , and vegetable oils . the invention also claims a method for obtaining the composition and the use thereof to prepare a drug or device for preventing , treating or curing psoriasis lesions on the head , the skin of the body or of the face .

Description:
the applicant of the present invention has been dedicated for the past years to the development of products based on snail slime of domestic species . its development has been eminently for cosmetic use , generating several products that include : hand , body and facial cream , shampoo , conditioning balm and bath soaps , all of them currently registered and in the market . considering that snail slime components possess the healing , regenerative and antiseptic properties , among others , the applicant thought of generating a product specifically formulated for the healing and regeneration of wounds and lesions derived from psoriasis . the inventors of the present application initially evaluated the product in a dermocosmetic manner as part of the popular use that is being given to snail slime , clearly taking advantage of the extraordinary qualities that have been seen in some people with different skin conditions , particularly psoriasis ( fig2 ). the product has been used as a complement to psoriatic treatments and it has been observed that the formulation with snail slime under study not only serves as a palliative treatment , but also curative for psoriatic lesions . it is therefore surprisingly clear that snail slime has an activity , which excels the conventional treatments . the present invention is further directed to the development of an application / device , from the developed product , which will be more efficient and effective than the current treatment , which is essentially palliative and curative . this treatment may , at best , stop the development of the psoriatic wounds . the use of the product that we will develop can also allow the desquamation of dead skin and regeneration of new skin due to the properties of its components . the product can be administered or installed by the patient , meaning the patient does not need to be moved and therefore does not require biomedical human resources associated with the treatment of the disease . for this , the device has a monograph of use with the appropriate indications for its better effectiveness . in summary , the product / composition to be developed is an application / device as a patch or band ( fig1 ), easy to use for both qualified personnel and the patient himself , and can be of variable size . its use is complementary to any other treatment . the previous investigation of the state of the art has concluded that there is no national or worldwide alternative to this product , so that this would be novel , inventive and certainly with clear industrial application , the three fundamental aspects for the acceptance of a patent . both the formulation and the form of application are novel because in previous analyzes of our group it has been possible to observe a greater effectiveness of this form or device versus the cream or gel applied on the diseased or ulcerous skin , which undergoes chemical and photochemical transformations , or microbiological processes that diminish its effectiveness and time of therapeutic utility . the examples set forth below are incorporated by way of illustration only in order to promote understanding of the specification and do not imply that they limit in any way the scope of the claims being sought . for the manufacture of 15 to 20 gel patches the following procedure is performed : 50 grams of body cream are sterilized by autoclaving at 150 ° c ., with a rise time of temperature , exposure time and cooling time ( 30 minutes ), then 30 grams of sterilized helix aspersa muller snail slime are added , homogenizes with stirring , then 10 ml liquid petroleum jelly and 10 ml bi - distilled water are added to maintain moisture . it is homogenized and then the patches are soaked with the gelatinous formulation having a viscosity of between 500 and 1 , 000 pa · s . the product is applied as a lotion , cream , gel , shampoo or patch containing these formulations , directly on the wound as follows , in the following cases : the product muciderm snail shampoo is applied to the hair of people suffering from psoriasis , as follows : case 1 : mildly ill : apply 5 to 10 ml of the chamomile - honey shampoo and massage the hair with the tip of the fingers for one minute , let the hair stand for two minutes and then rinse with plenty of water . then the conditioning balm is applied in the proper way ; that is : apply and massage the hair with the tip of the fingers for one minute let the hair rest for two minutes and then rinse with plenty of water . case 2 : mildly ill or sicker : apply 5 to 10 ml of nettle shampoo and massage the hair with the tip of the fingers for one minute , let the hair rest for two minutes and then rinse with plenty of water . then the conditioner is applied in the same way , that is : apply and massage the hair with the tip of the fingers for one minute let the hair rest for two minutes and then rinse with plenty of water . possible cases of allergy should change to chamomile - honey shampoo . the product muciderm snail soap , is applied in the body of people suffering from psoriasis , as follows : case 1 : mildly sick : apply the chamomile - honey soap on the affected area with a sponge for at least 3 minutes and then rinse with plenty of water . then the body lotion / cream is applied to the affected area . it is recommended to do this procedure twice a day for at least 3 days . case 2 : mildly ill or sicker : apply the nettle soap on the affected area with a sponge , at least 3 minutes and then rinse with plenty of water . then the body lotion / cream is applied to the affected area . possible cases of allergy , should be changed to chamomile - honey soap . it is recommended to do this toilet twice a day . case 3 : sick to severe : in patients with episodes of obvious and severely irritating psoriasis , the gel patch ( fig3 ) should be applied with nettle in the affected area at night and left until the following morning , then wash the area with plenty of water and apply the body lotion / cream with nettle in the affected area . this process should be performed for 7 to 10 days . possible cases of allergy , should be changed to chamomile - honey soap . the muciderm repair cream product ( face ) is applied to the face of people suffering from psoriasis , as follows : case 1 : slightly ill : apply a minimal amount of chamomile - honey soap with a sponge all over the face , then rinse with plenty of water and finally apply face cream all over the face . the procedure should be performed at least twice a day . case 2 : mildly ill or sicker : apply a minimal amount of nettle soap with a sponge all over the face , then rinse with plenty of water and finally apply face cream all over the face . the procedure should be performed at least twice a day . if allergy occurs , chamomile - honey soap should be used . a 25 - year - old girl with concurrent episodes of severe psoriasis in the arm , with an elemental lesion , i . e . an erythematous papule or plaque of varying size and dark red tone , borders and scaly , with bleeding ( auspitz sign ), that is , petechiae as a consequence of the vascular damage of the dermal papillae , by the detachment of the epidermis that covers them , was treated with the gel patch of example 2 ( fig3 ) with nettle in the affected area . the treatment consisted of the nocturnal application until the next morning of the patch on the injury , washing later the zone with abundant water . this process was performed for 10 days , a procedure that completely reversed the episode of psoriasis in the arm ( fig2 ), with no hyperkeratosis of the epidermis not evidencing the elemental lesion . it was observed that the decrease of the cutaneous sign was produced along with the elimination of urine of more intense color . fig1 : photograph of helix aspersa miller snail strain fig2 : results of application of the patch - embedded product on arm skin with a seriologic episode . a ) day 1 ( box indicates mode of application of the patch ), b ) day 3 , c ) day 5 , d ) day 10 . fig3 : shape and dimensions of the various gauze patches or gel - embedded bandages of the invention for therapeutic purposes . abad r , therapeutic and cosmetic compositions for treatment of skin , patente número 5538740 , 1996 . coto e , santos - juanes j , coto - segura p , alvarez v . new soriasis susceptibility genes : momentum for skin - barrrier disruption . j inves dermatol . 2011 may : 131 ( 5 ): 1003 - 5 . de korte j ., mombers f . m . c ., sprangers m . a . g . and j . d . bos , the suitability of quality - of - life questionnaires for soriasis research : a systematic literature review , arch dermatol 138 ( 2002 ), pp . 1221 - 1227 . denda s , denda m , inoue k , hibino t . glycolic acid induces keratinocyte proliferation in a skin equivalent model via trpv1 activation . j dermatolsci . 2010 february ; 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