Opinion ID: 4146690
Heading Depth: 3
Heading Rank: 1

Heading: A controlled-release tablet for releasing a

Text: drug into at least a portion of a region defined by the stomach and the upper gastrointestinal tract, said tablet comprising a solid monolithic matrix with said drug dispersed therein, said matrix comprising a combination of poly(ethylene oxide) and hydroxypropyl methylcellulose at a weight ratio that causes said matrix to swell upon con- tact with gastric fluid to a size large enough to provide gastric retention, wherein; 4 IN RE: DEPOMED, INC. said drug has a solubility in water that ex- ceeds one part of said drug per ten parts of water, by weight, and wherein; said poly(ethylene oxide) has a viscosity aver- age molecular weight from about 2,000,000 to about 10,000,000, and wherein said hydroxypropyl methylcellulose has a vis- cosity of from about 4,000 centipose to about 200,000 centipose, measured as a 2% solution in water. ’340 patent col. 11 l. 60 – col. 12 l. 9.