PATENT CLAIM ANALYSIS

Application Number: 16384644
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["536", "024500"]

Abstract:
One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The sense strand of the dsRNA agent comprises at least one thermally destabilizing nucleotide, and at least one said thermally destabilizing nucleotide occurring at a site opposite to the seed region (positions 2-8) of the antisense strand; and the antisense strand of the dsRNA agent comprises at least two modified nucleotides that provide the nucleotide a steric bulk that is less than or equal to the steric bulk of a 2′-OMe modification, wherein said modified nucleotides are separated by 11 nucleotides in length. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.

Claim (Index 5):
The dsRNA agent of  claim 1 , wherein T2\u2032 is positions 6-10 from the 5\u2032 end of the antisense strand, and q 4  is 1.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 100.0
- Lexical Diversity: 1.91463
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15504855', '16272721', '14976261', '14699140', '15151568']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6726577130375877
- 35 USC 102 Novelty (BERT): 0.6785741211116211
- Combined Prediction Score: 0.6732493538449911
- Mean Citation Score: 507.95110000000005
- Max Citation Score: 704.56256
- Similarity Product: 658.9021437218094

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test