PATENT CLAIM ANALYSIS

Application Number: 15941400
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-04
Patent Classification: ["546", "043000"]

Abstract:
Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.

Claim (Index 13):
A process for preparing oxycodone or a salt or solvate thereof from thebaine, the process comprising or consisting of the steps (a) oxidizing the thebaine to 14-hydroxycodeinone; (b) adding an acid H + n X n\u2212  to the reaction mixture before, during and/or after the oxidation reaction; (c) optionally precipitating the resulting 14-hydroxycodeinone as 14-hydroxycodeinone salt or a solvate thereof; (d) optionally isolating the precipitated 14-hydroxycodeinone salt or solvate thereof; (e) providing a solution or suspension of the 14-hydroxycodeinone salt or solvate thereof; (f) adding trifluoroacetic acid and/or a glycol; and (g) reducing the 14-hydroxycodeinone present in the solution or suspension to the oxycodone by hydrogenation; and (h) optionally adding a base, thus raising the pH to a pH where the oxycodone precipitates as its free base, and isolating the oxycodone as its free base or a solvate thereof, wherein X n\u2212  is an anion selected from the group consisting of Cl \u2212 , HSO 4 \u2212 , SO 4 2\u2212 , methanesulfonate, tosylate, trifluoroacetate, H 2 PO 4 \u2212 , HPO 4 2\u2212 , PO 4 3\u2212 , oxalate, perchlorate, and any mixtures thereof; and n is 1, 2, or 3.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 90.0
- Lexical Diversity: 1.15385
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15110825', '15700345', '14465470', '14132737', '14465512']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7767082172915624
- 35 USC 102 Novelty (BERT): 0.5632744350058241
- Combined Prediction Score: 0.7553648390629886
- Mean Citation Score: 329.726112
- Max Citation Score: 456.16953
- Similarity Product: 417.0419067504323

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test