PATENT CLAIM ANALYSIS

Application Number: 16204566
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["540", "519000"]

Abstract:
The present invention relates to certain diaryl inacrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Claim (Index 72):
A compound of the Formula (V): wherein\n M is CH or N; \n X 1  and X 1 \u2032 are independently \u2014C(R 1a )(R 2a )\u2014, \u2014S\u2014, \u2014S(O)\u2014, \u2014S(O) 2 \u2014, \u2014O\u2014 or \u2014N(R k \u2032)\u2014; \n each R 1a  and R 2a  is independently H, deuterium, C 1-6 alkyl, C 3-6 cycloalkyl, C 6-10  aryl, \u2014C(O)OR a \u2032, \u2014C(O)NR a \u2032R b \u2032, \u2014NR a \u2032R b \u2032, \u2014SR a \u2032, \u2014S(O)R a \u2032, \u2014S(O)NR a \u2032, \u2014S(O) 2 R a \u2032, \u2014S(O) 2 NR a \u2032 or \u2014OR a \u2032 wherein each hydrogen atom in C 1-6 alkyl is independently optionally substituted by deuterium, halogen, \u2014OH, \u2014OC 1-4 alkyl, \u2014NH 2 , \u2014NH(C 1-4 alkyl), \u2014N(C 1-4 alkyl) 2 , NHC(O)C 1-4 alkyl, \u2014N(C 1-4 alkyl)C(O)C 1-4 alkyl, \u2014NHC(O)NHC 1-4 alkyl, \u2014N(C 1-4 alkyl)C(O)NHC 1-4 alkyl, \u2014NHC(O)N(C 1-4 alkyl) 2 , \u2014N(C 1-4 alkyl)C(O)N(C 1-4 alkyl) 2 , \u2014NHC(O)OC 1-4 alkyl, \u2014N(C 1-4 alkyl)C(O)OC 1-4 alkyl, \u2014CO 2 H, \u2014CO 2 C 1-4 alkyl, \u2014CONH 2 , \u2014CONH(C 1-4 alkyl), \u2014CON(C 1-4 alkyl) 2 , \u2014SC 1-4 alkyl, \u2014S(O)C 1-4 alkyl, \u2014S(O) 2 C 1-4 alkyl, \u2014S(O)NH(C 1-4 alkyl), \u2014S(O) 2 NH(C 1-4 alkyl), \u2014S(O)N(C 1-4 alkyl) 2 , \u2014S(O) 2 N(C 1-4 alkyl) 2 , C 3-6 cycloalkyl, or 3- to 7-membered heterocycloalkyl; \n R 3a  and R 3b  are each independently H, fluoro, chloro, bromo, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, isopropoxy, \u2014CN, or \u2014CF 3 ; \n R 7a  is H, C 1-6 alkyl or 3-to 7-membered heterocycloalkyl, wherein each hydrogen atom in C 1-6 alkyl or 3-to 7-membered heterocycloalkyl is independently optionally substituted by halogen, \u2014OH, \u2014OC 1-4 alkyl, \u2014NH 2 , \u2014NH(C 1-4 alkyl), \u2014N(C 1-4 alkyl) 2 , \u2014CO 2 H, \u2014CO 2 C 1-4 alkyl, \u2014CONH 2 , \u2014CONH(C 1-4 alkyl), \u2014CON(C 1-4 alkyl) 2 , cycloalkyl, or monocyclic heterocycloalkyl; \n each R k \u2032 is independently H, deuterium, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3-to 7-membered heterocycloalkyl, C 6-10  aryl, or mono- or bicyclic heteroaryl; wherein each hydrogen atom in C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, or mono- or bicyclic heteroaryl in R k \u2032 is independently optionally substituted by deuterium, halogen, C 1-6 alkyl, C 1-6 haloalkyl or \u2014OR a \u2032; \n wherein each R a \u2032 and R b \u2032 is independently H, deuterium, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, or heteroaryl; \n each Z 1 , Z 2 , Z 3 , Z 4 , Z 5 , Z 6  or Z 7  is independently N, NH, or C(R x ), wherein each R x  when present is independently H, deuterium, halogen, C 1-4 alkyl, \u2014O\u2014C 1-4 alkyl, \u2014OH, \u2014NH 2 , \u2014NH(C 1-4 alkyl), \u2014NH(phenyl), \u2014NH(heteroaryl), CN, or \u2014CF 3 , provided that at least one of Z 1 , Z 2 , Z 3 , Z 4 , Z 5 , Z 6  or Z 7  is N or NH, provided that the compound does not comprise a moiety of the formula \n and m\u2032 is 2 or 3;\n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 98.0
- Lexical Diversity: 1.35714
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15609962', '15113583', '15740462', '16320589', '14397200']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7235379657553118
- 35 USC 102 Novelty (BERT): 0.6595128614729795
- Combined Prediction Score: 0.7171354553270786
- Mean Citation Score: 526.013384
- Max Citation Score: 617.3812
- Similarity Product: 608.9437900958777

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test