PATENT CLAIM ANALYSIS

Application Number: 15760783
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-02
Patent Classification: ["435", "007100"]

Abstract:
Disclosed are biomarkers for Parkinson's disease (PD), including idiopathic PD (idPD). The present invention relates generally to assays, kits, compositions, solid supports and methods that measure a decrease in the expression or function of PLA2g6(L) variant of PLA2g6 (PARK 14) gene in a sample from the subject, including non-neuronal cells as a biomarker for preclinical (prodromal) or early stage Parkinson's disease (PD) and idiopathic PD (idPD), as well as assays, kits, compositions and methods that can detect the functional consequences of decreased expression of PLA2g6(L), including decreased store operated Ca2+ entry (SOCE), deficit of Ca2+ in endoplasmic reticulum stores, and autophagic dysfunction in the cells obtained from the subjects in preclinical (prodromal) and early stage PD diagnosis and for monitoring Parkinson's Disease progression.

Claim (Index 3):
An assay for detecting Parkinson's disease (PD) in a subject, or detecting a subject at risk of developing PD, the assay comprising;\n a. contacting a sample obtained from the subject with an antibody that specifically binds to PLA2g6(L) (i.e., anti-PLA2g6(L) antibody), and at least one of; (i) a pan specific anti-PLA2g6 antibody that binds to PLA2g6(L) and PLA2g6(S) proteins, (ii) an anti-PLA2g6(S) antibody, (iii) an anti-normalizing protein antibody b. detecting and quantification of binding between the anti-PLA2g6(L) antibody and PLA2g6(L) protein, and detecting and quantification at least one of: the binding between the anti-PLA2g6 antibody and the PLA2g6(L) and PLA2g6(S) proteins, the binding between anti-PLA2g6(S) antibody and PLA2g6(S) protein, and the binding between anti-normalizing protein antibody and normalizing protein; and c. calculating the ratios of any one or more of:\n i. the amount of PLA2g6(L) protein to PLA2g6(S) protein \n ii. the amount of PLA2g6(L) protein to total PLA2g6 protein \n iii. the amount of PLA2g6(L) protein to normalizing protein

Metadata:
- Claim Count in Document: 58.0
- Percentile: 90.0
- Lexical Diversity: 2.0641
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15464047', '14213359', '14654998', '13307485', '12279871']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.552494606384612
- 35 USC 102 Novelty (BERT): 0.541477284262635
- Combined Prediction Score: 0.5513928741724143
- Mean Citation Score: 273.53267800000003
- Max Citation Score: 386.2139
- Similarity Product: 248.0566052138031

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test