PATENT CLAIM ANALYSIS

Application Number: 16380713
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["514", "285000"]

Abstract:
The present invention provides novel neuromodulatory compounds and compositions thereof The invention also relates to methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; as well as intermediates for the preparation compounds.

Claim (Index 1):
A method of treating heart disease comprising, administering to a subject in need thereof a therapeutically effective amount of a compound represented by structural Formula (I): or a salt thereof, wherein:\n  represents an optional double bond; \n R 1  is selected from hydrogen; and C 1 -C 3  alkyl, C 3 -C 5  cycloalkyl, C 2-4  alkenyl, C 3 -C 5  cycloalkenyl, C 2-4  alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), and \u2014CN; \n R 2  is selected from C 1 -C 3  haloalkyl and C 3  cycloalkyl, wherein C 3  cycloalkyl is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), and \u2014CN; \n R 3  is selected from halogen, C 1 -C 3  alkyl, C 1 -C 3  haloalkyl, \u2014OR 10  , \u2014SR 10 , \u2014N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , and \u2014CN; \n R 4  is absent or selected from hydrogen and OR 10 , wherein R 4  is absent when   is a double bond and R 4  is selected from hydrogen and OR 10  when   is a single bond; \n R 5  is selected from C 1 -C 3  alkyl optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ) 2 , and \u2014CN, wherein when R 2  is selected from C 1  haloalkyl and   is a double bond, R 5  is C 1 -C 3  alkyl optionally substituted with one or more substituents independently selected from \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), and \u2014CN; \n R 6  is CH 2 CH 3  when R 2  is C 1 -C 3  haloalkyl, and when R 2  is C 3  cycloalkyl, R 6  is C 1 -C 3  alkyl substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014N(R 10 ) 2 , \u2014NO 2 , \u2550O, and \u2014CN; \n R 7  is selected from C 1 -C 3  alkyl, C 2-4  alkenyl, and C 2-4  alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), and \u2014CN; \n R 10 ) is independently selected at each occurrence from hydrogen; and C 1 -C 3  alkyl optionally substituted with one or more substituents independently selected from halogen, \u2014OH, \u2014OCH 3 , \u2014CF 3 , \u2014SH, \u2014NH 2 , \u2014NO 2 , and \u2014CN; and \n n is selected from 0, 1, 2, and 3.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 100.0
- Lexical Diversity: 1.51515
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15997616', '15509989', '16274130', '16274132', '15774262']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7538790282531141
- 35 USC 102 Novelty (BERT): 0.5329932108462744
- Combined Prediction Score: 0.7317904465124302
- Mean Citation Score: 327.456672
- Max Citation Score: 353.1478600000001
- Similarity Product: 305.2397186459328

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test