PATENT CLAIM ANALYSIS

Application Number: 15563888
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "256000"]

Abstract:
A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis, eczema, itch or psoriasis, is disclosed. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

Claim (Index 1):
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n L is selected from the group consisting of a bond, \u2014O\u2014, \u2014C(O)\u2014, \u2014C(O)O\u2014, \u2014C(O)N(R L )\u2014, \u2014S\u2014, \u2014S(O)\u2014, and \u2014S(O) 2 \u2014; \n R L  is selected from the group consisting of hydrogen and C 1 -C 6 -alkyl; \n R 1  is selected from the group consisting of hydrogen, halogen, cyano, imino, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -alkynyl, C 3 -C 6 -cycloalkyl, C 5 -C 10 -cycloalkenyl, aryl, 4- to 10-membered ring heterocyclyl, and 5- to 10-membered ring heteroaryl; wherein:\n the imino may be unsubstituted or substituted with one or two substituents independently selected from the group consisting of hydroxyl, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, aryl and 5- to 10-membered ring heteroaryl; \n the R 1  C 1 -C 10 -alkyl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, amino, cyano, C 3 -C 6 -cycloalkyl, aryl, 5- to 10-membered ring heteroaryl, 4- to 10-membered ring heterocyclyl, \u2014OR 101 , \u2014C(O)OR 102 , and \u2550NR 103 ;\n wherein the amino, C 3 -C 6 -cycloalkyl, aryl, 5- to 10-membered ring heteroaryl, 4- to 10-membered ring heterocyclyl substituents of the R 1  C 1 -C 10 -alkyl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 3 -C 6 -cycloalkyl, halo-C 1 -C 6 -alkyl, and 4- to 10-membered ring heterocyclyl; \n wherein R 101  and R 102  are independently selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, halo-C 3 -C 6 -cycloalkyl, C 1 -C 6 -alkyl-C 3 -C 6 -cycloalkyl, aryl, haloaryl, and C 1 -C 6 -alkylaryl; and \n wherein R 103  is selected from the group consisting of hydrogen, hydroxy, C 1 -C 6 -alkyl, and C 1 -C 6 -alkoxy; \n \n the R 1  C 2 -C 10 -alkenyl and the R 1  C 2 -C 10 -alkynyl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of hydroxy, C 1 -C 6 -alkoxy, C 3 -C 6 -cycloalkyl, aryloxy, 5- to 10-membered ring heteroaryloxy, C 1 -C 6 -alkoxycarbonyl, alkylsilyl, and cyano-C 1 -C 6 -alkylcarbonylamino; \n the R 1  C 3 -C 6 -cycloalkyl and the R 1  C 3 -C 6 -cycloalkenyl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, cyano, oxo, OH, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkyoxycarbonylamino, and halo-C 1 -C 6 -alkoxycarbonyl; \n the R 1  aryl and the R 1  5- to 10-membered ring heteroaryl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6  alkoxy, hydroxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, cyano-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 6 -alkyl, C 5 -C 10 -cycloalkenyl, aryl, aryl-C 1 -C 6 -alkyl, 4- to 10-membered ring heterocyclyl, 4- to 10-membered ring heterocyclyl-C 1 -C 6 -alkyl, 5- to 10-membered ring heteroaryl, 5- to 10-membered ring heteroaryl-C 1 -C 6 -alkyl, \u2014OR 104 , C(O)OR 105 , \u2014N(R 106 )C(O)R 107 , \u2014N(R 108 )C(O)NR 109 R 110 , \u2014S(O) 2 R 111 , \u2014S(O) 2 NR 112 R 113 , and \u2014NS(O) 2 NR 112 R 113 ;\n wherein the C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 6 -alkyl, C 5 -C 10 -cycloalkenyl, aryl, aryl-C 1 -C 6 -alkyl, 4- to 10-membered ring heterocyclyl, 4- to 10-membered ring heterocyclyl-C 1 -C 6 -alkyl, 5- to 10-membered ring heteroaryl, and 5- to 10-membered ring heteroaryl-C 1 -C 6 -alkyl of the R 1  aryl and the R 1  5- to 10-membered ring heteroaryl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, cyano-C 1 -C 6 -alkyl, and C 1 -C 6 -alkoxycarbonyl; \n wherein R 104 , R 105 , R 107 , R 109 , R 110 , R 111 , R 112 , and R 113  are independently selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxyC 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, cyano-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, halo-C 3 -C 6 -cycloalkyl, 4- to 10-membered ring heterocyclyl, 4- to 10-membered ring heterocyclyl-C 1 -C 6 -alkyl, aryl, haloaryl, and C 1 -C 6 -alkylaryl; and \n wherein R 106  and R 108  are independently selected from the group consisting of hydrogen and C 1 -C 6 -alkyl; and \n \n the R 1  4- to 10-membered ring heterocyclyl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, OH, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl, 4- to 10-membered ring heterocyclyl, and \u2014S(O) 2 R 14 ; wherein R 14  is selected from the group consisting of hydrogen and C 1 -C 6 -alkyl; \n \n R 2  is selected from the group consisting of C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 3 -C 6 -cycloalkyl, aryl, 4- to 10-membered ring heterocyclyl, and 5- to 10-membered ring heteroaryl; wherein:\n the R 2  C 1 -C 6 -alkyl or the C 2 -C 6 -alkenyl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, hydroxy, cyano, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 3 -C 6 -cycloalkyl, halo-C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkoxy, halo-C 3 -C 6 -cycloalkoxy, aryl, haloaryl, aryloxy, haloaryloxy, and C 1 -C 6 -alkylaryloxy; \n the R 2  C 3 -C 6 -cycloalkyl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, C 1 -C 6 -alkyl, and halo-C 1 -C 6 -alkyl; \n the R 2  aryl and the R 2  5- to 10-membered ring heteroaryl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, hydroxy, cyano, C 1 -C 6 -alkyl, hydroxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, cyano-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, \u2014S(O) 2 R 201 , and \u2014S(O) 2 NR 202 R 203 ; wherein R 201 , R 202 , and R 203  are independently selected from the group consisting of hydrogen and C 1 -C 6 -alkyl; and \n the R 2  4- to 10-membered ring heterocyclyl may be unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of halogen, C 1 -C 6 -alkyl, and halo-C 1 -C 6 -alkyl; \n \n R 3  and R 4  are independently selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, and C 3 -C 6 -cycloalkyl, wherein the C 1 -C 6 -alkyl may be substituted with one, two, or three halogen; \n R 5  is selected from the group consisting of hydrogen, methyl, methoxy, and cyano; and \n R 6  is selected from the group consisting of hydrogen or \u2014CH 2 -phosphate.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.37209
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13428259', '12636213', '15094687', '13503231', '14138941']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8276114091537748
- 35 USC 102 Novelty (BERT): 0.5352983427977038
- Combined Prediction Score: 0.7983801025181678
- Mean Citation Score: 349.872878
- Max Citation Score: 364.68573
- Similarity Product: 259.7276936799556

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test