PATENT CLAIM ANALYSIS

Application Number: 16285587
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "021100"]

Abstract:
The present invention includes novel cyclic peptides, and methods of using the same. The present invention further includes novel cyclic peptides conjugated with a gold nanoparticle, and methods of using the same.

Claim (Index 40):
A method of promoting virolysis of a virus, the method comprising contacting the virus with an effective amount of at least one cyclic compound of formula (I), or a salt, solvate, enantiomer or diastereoisomer thereof:\n Xaa 1 -Xaa 2 -Xaa 3 -Xaa 4 -Xaa 5 -Xaa 6 -Xaa 7 -Xaa 8 -Xaa 9 -P 1 \u2003\u2003(I), wherein in (I):\n Xaa 1  is selected from the group consisting of absent, Glu and Arg; \n Xaa 2  is selected from the group consisting of absent, Gly, Phe, Lys, Asp, Glu, Ile, Arg and Cit; \n Xaa 3  is selected from the group consisting of absent, Asn, Asp, Ile, Glu and 2-cyclohexylglycine; \n Xaa 4  is selected from the group consisting of Asn and Asp; \n Xaa 5  is a modified glycine of formula (III) \n \u2003wherein in (III) R is selected from the group consisting of C 1 -C 6  alkyl and C 3 -C 6  cycloalkyl; Xaa 6  is the modified proline of formula (IV) \u2003wherein in (IV) R is selected from the group consisting of naphthyl, p-methyl phenyl, p-ethyl phenyl, 2-phenylethyl, 1-adamantyl, 2-adamantyl and metallocene; Xaa 7  is selected from the group consisting of Trp and 3-(3-benzothienyl)-L-alanine; Xaa 8  is selected from the group consisting of Ser, Thr, 2,4-diaminobutanoic acid, Orn and Lys; Xaa 9  is selected from the group consisting of absent, 2,4-diaminobutanoic acid, Orn, Lys, Glu, Glu-Ala, Glu-Ala-Met, Glu-Ala-Met-Met, and 2-(2-(2-aminoethoxy)ethoxy)acetic acid; P 1  is a group that comprises at least one thiol group and is covalently linked through an amide bond to (i) the C-terminus of Xaa 9  if Xaa 9  is not absent, or (ii) the C-terminus of Xaa 8  if Xaa 9  is absent; the side chain amino group of one residue selected from the group consisting of 2,4-diaminobutanoic acid at Xaa 8 , Orn at Xaa 8 , Lys at Xaa 8 , 2,4-diaminobutanoic acid at Xaa 9 , Orn at Xaa 9 , and Lys at Xaa 9  forms an amide bond with the side chain carboxylic acid group of one residue selected from the group consisting of Glu at Xaa 2 , Asp at Xaa 2 , Glu at Xaa 3 , Asp at Xaa 3  and Asp at Xaa 4 .

Metadata:
- Claim Count in Document: 2.0
- Percentile: 99.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15533075', '14714198', '15514983', '13262186', '12675334']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7895330639425046
- 35 USC 102 Novelty (BERT): 0.5896659572025289
- Combined Prediction Score: 0.769546353268507
- Mean Citation Score: 400.002888
- Max Citation Score: 683.1574
- Similarity Product: 400.54284941303735

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test