PATENT CLAIM ANALYSIS

Application Number: 15986961
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "004800"]

Abstract:
The invention relates to MIC-1 compounds. More specifically it relates to compounds comprising a MIC-1 polypeptide with an N-terminal amino acid extension and a protractor wherein the amino acid extension comprises 3 to 36 amino acid residues and where the MIC-1 polypeptide and the N-terminal amino acid extension together have a calculated pI lower than 6.5. The compounds of the invention have MIC-1 activity. The invention also relates to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable excipients, as well as the medical use of the compounds.

Claim (Index 1):
A MIC-1 compound, comprising\n a MIC-1 polypeptide; an amino acid extension attached to the N-terminal of the MIC-1 polypeptide; and a protractor attached to the amino acid extension; wherein the amino acid extension comprises 3 to 36 amino acid residues; wherein one of the amino acid residues is a Cys and the remainder of the amino acid residues are selected from the group consisting of Ala, Glu, Gly, Pro, Ser, and Thr; wherein the distance between the Cys residue and the N-terminal amino acid of the MIC-1 polypeptide is at least 10 amino acids; wherein the protractor is attached to the amino acid extension at the Cys residue; wherein the protractor comprises Chem. 1, Chem. 2, Chem. 3, and Chem. 4; wherein Chem. 1 is selected from the group consisting of: Chem. 1A: HOOC\u2014(CH 2 ) x \u2014CO\u2014*, Chem. 1B: HO\u2014S(\u2550O) 2 \u2014(CH 2 ) x \u2014CO\u2014*, Chem. 1C: HOOC-benzene-O\u2014(CH 2 ) y \u2014CO\u2014*, and Chem. 1D: (1H-tetrazol-5-yl)-(CH 2 ) x \u2014CO\u2014*, wherein x is an integer in the range of 12-20, and wherein y is an integer in the range of 5-15; wherein Chem. 2 is selected from the group consisting of: Chem. 2A: *\u2014(NH\u2014CH(COOH)\u2014(CH 2 ) m \u2014CO k *, Chem. 2B: *\u2014(NH\u2014S(\u2550O) 2 \u2014(CH 2 ) m \u2014CO) k *, and Chem. 2C: *\u2014(NH\u2014(CH 2 ) m -cyclohexane-CO) k \u2014*, wherein m of Chem. 2 is an integer in the range of 1-5, and wherein k of Chem. 2 is an integer in the range of 0-4; wherein Chem. 3 is * (NH\u2014(CH 2 ) 2 \u2014[O\u2014(CH 2 ) 2 ] k \u2014O\u2014[CH 2 ] n \u2014CO\u2014*) l , wherein k of Chem. 3 is an integer in the range of 1-10, wherein n is an integer in the range of 1-5, and wherein I is an integer in the range of 0-5; wherein Chem. 4 is selected from the group consisting of: Chem. 4A: *\u2014NH\u2014(CH 2 ) m \u2014NH\u2014CO\u2014CH 2 \u2014*, and Chem. 4B: *\u2014NH\u2014CH(COOH)\u2014(CH 2 ) m \u2014NH\u2014CO\u2014CH 2 \u2014*, wherein m of Chem. 4 is an integer in the range of 1-5; wherein Chem. 1, Chem. 2, Chem. 3, and Chem. 4 are interconnected via amide bonds; wherein Chem. 4 at its CH 2 \u2014* end is connected to a sulphur atom of the Cys residue of the amino acid extension; and wherein the MIC-1 polypeptide with the amino acid extension has a calculated pI lower than 6.5.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 93.0
- Lexical Diversity: 1.87755
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15643543', '15453617', '15849920', '15301960', '15966642']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7760804043788593
- 35 USC 102 Novelty (BERT): 0.512750631437234
- Combined Prediction Score: 0.7497474270846968
- Mean Citation Score: 252.58439600000003
- Max Citation Score: 273.06088
- Similarity Product: 175.21915461956505

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test