PATENT CLAIM ANALYSIS

Application Number: 15983743
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["435", "325000"]

Abstract:
A genetically modified mouse is provided that comprises a conditional Acvr1 allele that comprises a mutated exon that, upon induction, converts to a mutant exon phenotype, wherein the mutant exon phenotype includes ectopic bone formation. Mice comprising a mutant Acvr1 exon 5 in antisense orientation, flanked by site-specific recombinase recognition sites, are provided, wherein the mice further comprise a site-specific recombinase that recognizes the site-specific recombinase recognitions sites, wherein the recombinase is induced upon exposure of the mouse to tamoxifen. Upon exposure to tamoxifen, the recombinase is expressed and acts on the RRS-flanked mutant exon 5 and places the mutant exon 5 in sense orientation and deletes the wild-type exon.

Claim (Index 12):
The rodent ES cell of  claim 8 , wherein the functioning Acvr1 exon 5 is a human exon 5 of the Acvr1 gene encoding glutamic acid at the first codon instead of aspartic acid.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 93.0
- Lexical Diversity: 2.01667
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14207320', '15336603', '11191157', '13940609', '09853033']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6815686090420039
- 35 USC 102 Novelty (BERT): 0.7009660617834473
- Combined Prediction Score: 0.6835083543161482
- Mean Citation Score: 579.0381639999998
- Max Citation Score: 997.1647
- Similarity Product: 710.792218740189

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test