PATENT CLAIM ANALYSIS

Application Number: 15881488
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["506", "002000"]

Abstract:
Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.

Claim (Index 1):
A method of detecting aneuploidy of one or more chromosomes of interest in a fetus, the method comprising:\n obtaining chromosome segments from a maternal blood sample comprising chromosome segments from the one or more chromosomes of interest and chromosome segments from one or more reference chromosomes; ligating at least one adapter to the chromosome segments, wherein the at least one adapter comprises a universal amplification sequence; performing universal amplification using universal primers that bind to the universal amplification sequence to generate amplified chromosome segments; measuring the amounts of amplified chromosome segments; and detecting aneuploidy of the one or more chromosomes of interest using the amounts of amplified chromosome segments from the one or more chromosomes of interest and the amounts of amplified chromosome segments from the one or more reference chromosomes.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 1.96341
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15881384', '15413200', '13949212', '15446778', '15191197']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6052602354511746
- 35 USC 102 Novelty (BERT): 0.6112035964352821
- Combined Prediction Score: 0.6058545715495853
- Mean Citation Score: 505.825778
- Max Citation Score: 532.1469999999998
- Similarity Product: 496.9050932592152

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test