PATENT CLAIM ANALYSIS

Application Number: 15947680
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["435", "462000"]

Abstract:
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Claim (Index 185):
A method of cleaving or editing a target DNA molecule or modulating transcription of a gene encoded by the target DNA molecule, the method comprising introducing a Type II Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)\u2014CRISPR associated (Cas) (CRISPR-Cas) system comprising\n (1) a single molecule DNA-targeting RNA, or a nucleic acid comprising a nucleotide sequence encoding said single molecule DNA-targeting RNA, wherein the single molecule DNA-targeting RNA comprises:\n i) a targeter-RNA that is capable of hybridizing with a target sequence in the target DNA molecule, and \n ii) an activator-RNA that is capable of hybridizing with the targeter-RNA to form a double-stranded duplex of a protein-binding segment, \n wherein i) and ii) are arranged in a 5\u2032 to 3\u2032 orientation and are covalently linked to one another with intervening nucleotides; wherein the single molecule DNA-targeting RNA is capable of forming a complex with a Cas9 protein and hybridization of the targeter-RNA to the target sequence is capable of targeting the Cas9 protein to the target DNA molecule, and (2) the Cas9 protein, or a nucleic acid comprising a nucleotide sequence encoding the Cas9 protein, into a eukaryotic cell containing the target DNA molecule having the target sequence.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 91.0
- Lexical Diversity: 2.25424
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13842859', '14942782', '15138604', '15803424', '15925544']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4108301207601216
- 35 USC 102 Novelty (BERT): 0.7124477212268715
- Combined Prediction Score: 0.4409918808067966
- Mean Citation Score: 736.72044
- Max Citation Score: 778.5936
- Similarity Product: 741.7501267327309

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test