PATENT CLAIM ANALYSIS

Application Number: 15978918
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["435", "445000"]

Abstract:
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention provides methods of characterization of cells differentiated into cells expressing markers characteristic of the pancreatic endocrine lineage utilizing unique surface markers. The present invention also provides methods to enrich or sort cells expressing markers characteristic of the pancreatic endocrine lineage. The present invention also provides methods to deplete cells that may contaminate populations of cells expressing markers characteristic of the pancreatic endocrine lineage formed by the methods of the present invention, thereby reducing the incidence of tumor formation in vivo following transplantation.

Claim (Index 1):
A method of enriching a population of primitive gut tube cells comprising:\n a) differentiating a population of human pluripotent stem cells into definitive endoderm cells with a TGF-\u03b2 receptor agonist; b) differentiating the definitive endoderm cells into a population of primitive gut tube cells; c) enriching the population of primitive gut tube cells by contacting the population of cells with a reagent that is capable of binding the Lif receptor.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 93.0
- Lexical Diversity: 2.1
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13036476', '13211972', '14882661', '12839041', '13708369']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6107809476161786
- 35 USC 102 Novelty (BERT): 0.6929037525794463
- Combined Prediction Score: 0.6189932281125055
- Mean Citation Score: 622.6862899999999
- Max Citation Score: 866.9731
- Similarity Product: 685.0146509560943

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test