PATENT CLAIM ANALYSIS

Application Number: 15895386
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["530", "387900"]

Abstract:
The present invention relates to antibodies targeting the membrane bound IgM (mIgM) of the B-cell receptor complex found in B-cell lymphomas and leukemias and uses thereof. Another aspect of the present invention is the use of anti-B-Cell mIgM antibodies in the treatment of Be-cell malignancies, including B-cell lymphomas and leukemias.

Claim (Index 53):
A method for purifying membrane bound IgM (mIgM) of a B-cell Receptor Complex in a sample comprising (a) attaching monoclonal antibodies designated mAb1-1 produced by a hybridoma cell line from fusion 117 (ATCC deposit number PTA-121719) alone or in combination with monoclonal antibodies designated mAb2-2b produced by a hybridoma cell line from fusion 118 (ATCC deposit number PTA-121717) and monoclonal antibodies designated mAb3-2b produced by a hybridoma cell line from fusion 118 (ATCC deposit number PTA-121718) to a solid support; (b) contacting the immobilized antibodies with the sample; (c) washing the solid support with a first solvent to remove substantially all the material in the sample except the mIgM of the B-cell Receptor Complex that is bound to the immobilized antibodies; and (d) washing the solid support with a second solvent to release the mIgM of the B-cell Receptor Complex from the immobilized antibodies.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 88.0
- Lexical Diversity: 1.52778
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15101658', '13612070', '14295579', '10846981', '13198263']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.662724205858494
- 35 USC 102 Novelty (BERT): 0.6722863891586388
- Combined Prediction Score: 0.6636804241885085
- Mean Citation Score: 391.229066
- Max Citation Score: 726.9009
- Similarity Product: 647.154827837652

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test