PATENT CLAIM ANALYSIS

Application Number: 16177165
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["424", "188100"]

Abstract:
The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.

Claim (Index 24):
The method of  claim 23 , wherein HIV-1 vaccine immunogen comprises an UFO gp140 trimer, a self-assembling nanoparticle generated with a subunit sequence as shown in any one of SEQ ID NOs:18 and 5-17, and a T-helper epitope sequence comprising the sequence as shown in SEQ ID NO:1, wherein the T-helper epitope sequence (a) is fused to the C-terminus of the nanoparticle subunit via a short peptide spacer while the UFO gp140 trimer subunit is fused to the N-terminus of the nanoparticle subunit or (b) covalently links the UFO gp140 trimer subunit at its C-terminus to the N-terminus of the nanoparticle subunit.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 97.0
- Lexical Diversity: 2.125
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16176200', '15508885', '14806742', '14072209', '15075329']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7655300642093932
- 35 USC 102 Novelty (BERT): 0.5681909581607826
- Combined Prediction Score: 0.7457961536045321
- Mean Citation Score: 385.3784480000001
- Max Citation Score: 485.73978
- Similarity Product: 366.2165295227159

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test