PATENT CLAIM ANALYSIS

Application Number: 15771043
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-02
Patent Classification: ["514", "021300"]

Abstract:
The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

Claim (Index 35):
The method of  claim 1 , wherein at least one alkyl, cycloalkyl, alkenyl or alkynyl group is selected from the group consisting of 2,2,2-trifluoro-1-ethyl, 2,2,3,3,3-pentafluoro-1-propyl, 2,2,3,3,4,4,4-heptafluoro-1-butyl, ethyl, isopropyl, benzyl, substituted benzyl, adamant-1-yl-methyl, quinolin-4-yl-methyl, 2-amino-1-propyl, 4-phenyl-benzyl, 1H-imidazol-4-yl-methyl, 4-hydroxy-benzyl, 4[3-(trifluoromethyl)-3H-diazirine]-benzyl, and (8R,9R,13S,14R)-3,17-dihydroxy-13 -methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl-ethynyl-methyl.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 91.0
- Lexical Diversity: 1.59524
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12845455', '13130962', '14182706', '13697021', '12066324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7938281260536109
- 35 USC 102 Novelty (BERT): 0.506704838632824
- Combined Prediction Score: 0.7651157973115322
- Mean Citation Score: 258.376928
- Max Citation Score: 264.86304
- Similarity Product: 180.9116937911797

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test