PATENT CLAIM ANALYSIS

Application Number: 15860356
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["435", "377000"]

Abstract:
The disclosure provides methods and compositions useful for obtaining induced stem cells, methods of making and use thereof.

Claim (Index 3):
The method of  claim 1 , further comprising\n transforming somatic cells with an RNA replicon comprising a plurality of non-structural replicase domains from an alphavirus and at least four heterologous polynucleotides that encode reprogramming factors (RFs) for inducing the generation of stem cells when expressed in the somatic cell; culturing the transformed somatic cells, for at least 30 days under conditions to express the RFs; and isolating stem cells, wherein the RNA replicon comprises from 5\u2032 to 3\u2032: (i) polynucleotide sequences encoding the plurality of non-structural replicase domains obtained from an alphavirus; (ii) a promoter; (iii) RF 1 ; (iv) a coding sequence for a first self-cleaving peptide; (v) RF 2 ; (vi) a coding sequence for a second self-cleaving peptide; (vii) RF 3 ; (viii) an IRES; (ix) RF 4 ; (x) an optional IRES or an optional promoter; (xi) an optional sequence encoding an optional selectable marker; (xii) an alphavirus 3\u2032 UTR and polyA tail; and wherein RF 1-4  are polynucleotides encoding RFs selected from the group consisting of Oct-3, Oct-4, Klf, Sox-2, c-Myc, n-Myc, L-Myc, Nanog, and Glis1.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.11111
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14402924', '13088009', '12743776', '13590880', '14311545']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6377932769244139
- 35 USC 102 Novelty (BERT): 0.7628109814027578
- Combined Prediction Score: 0.6502950473722484
- Mean Citation Score: 540.3153980000002
- Max Citation Score: 1017.5787
- Similarity Product: 890.8880527911545

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test