PATENT CLAIM ANALYSIS

Application Number: 16050312
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-05
Patent Classification: ["424", "186100"]

Abstract:
This invention teaches systems and methods for identifying, targeting and destroying cancer cells. As cells progress from a normal to a cancerous state their accelerated metabolic rates and adapted pathways generate a higher heat signature that serves as a targeting beacon for a specialized cell killing vector. Suitable vectors include modified or adapted viruses, modified or adapted intracellular bacteria and/or engineered liposomes. Especially preferred is the bacterial vector because of its ease of production. The bacterial vector is selectively targeted to recognize cells whose temperature is slightly elevated and ambient pH suppressed due to cancer related alterations to metabolism. An additional targeting feature, such as recognition of the MCT4 transmembrane protein exaggeratively expressed on the cancer cell outer membrane, may provide additional targeting specificity. Embodiments featuring facultative extracellular and intracellular growth capable bacteria have the preferred feature that culture conditions for producing the vector can be optimized solely for the one organism and need not be compromised to support or optimize host cell maintenance.

Claim (Index 13):
The method of  claim 1  wherein said bacteria are cultured in eukarotic cells.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 95.0
- Lexical Diversity: 1.52174
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15177243', '11349731', '13560159', '10824027', '14917764']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6734766201699434
- 35 USC 102 Novelty (BERT): 0.4937021469484045
- Combined Prediction Score: 0.6554991728477896
- Mean Citation Score: 155.76996599999995
- Max Citation Score: 162.65814
- Similarity Product: 108.1090010521245

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test