PATENT CLAIM ANALYSIS

Application Number: 15754173
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "006500"]

Abstract:
The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compositions comprising such insulin derivatives, and relates to the use of such derivatives for the treatment or prevention of medical conditions relating to diabetes.

Claim (Index 1):
An acylated analogue of human insulin, which analogue is [B3aar 1 , desB30] relative to human insulin; wherein\n aar 1  represents Glu (E), Gln (Q), Asp (D), Ser (S) or Thr (T); and one or two of the amino acid residues located in positions B26, B27 and/or B28 are substituted for Glu (E) and/or Asp (D); which analogue may additionally comprise an A8aar 2  substitution, and/or an A14Glu (E) substitution, and/or an A21aar 3  substitution; wherein aar 2  represents His (H) or Arg (R); and aar 3  represents Gly (G) or Ala (A); which insulin analogue is derivatized by acylation of the epsilon amino group of the naturally occurring lysine residue at the B29 position with a group of Formula II\n [Acyl]-[Linker]- \n wherein the Linker group is an amino acid chain composed of from 1 to 10 amino acid residues selected from gGlu and/or OEG; wherein gGlu represents a gamma glutamic acid residue; OEG represents a residue of 8-amino-3,6-dioxaoctanoic acid (i.e. a group of the formula \u2014NH\u2014(CH 2 ) 2 \u2014O\u2014(CH 2 ) 2 \u2014O\u2014CH 2 \u2014CO\u2014); which amino acid residues may be present in any order; and which amino acid chain comprises at least one gGlu residue; and wherein the Acyl group is a residue of an \u03b1,\u03c9-di-carboxylic acid selected from 1,14-tetradecanedioic acid; 1,15-pentadecanedioic acid; and 1,16-hexadecanedioic acid.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 88.0
- Lexical Diversity: 1.63158
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15121206', '14471258', '14616293', '14686176', '12673337']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8366401933457347
- 35 USC 102 Novelty (BERT): 0.6183516566438545
- Combined Prediction Score: 0.8148113396755466
- Mean Citation Score: 494.690622
- Max Citation Score: 651.9261
- Similarity Product: 489.0628582150698

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test