PATENT CLAIM ANALYSIS

Application Number: 15897688
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "414000"]

Abstract:
Disclosed are 3-indolyl furanoid compounds which are useful as potent anti-inflammatory agents and prevent gastric ulcer by inhibiting matrix metalloproteinase-9 (MMP-9) expression in gastric mucosal layer. For example, disclosed is a compound of formula 1, wherein: R 1  to R 6  is selected from H, OH, CH 3 , OCH 3 , Br, Cl, Ph or o-OHC 6 H 4 , OCH 2 —CH═CH 2 , or OCH 2 CH 2 CH 3 , and R 1  to R 6  is having at least one substituent with alkyl, aryl and heteroaryl groups other than H, wherein the carbon in alkyl, aryl and heteroaryl is in the range of C1 to C8. Various embodiments relate to representative compounds of Formula 1 and method of preparation thereof. Further embodiments relates to the use of representative compounds of Formula 1 in treating diseases associated with gastric ulcer and other inflammatory diseases. A noted feature of an embodiment is the IC50 value of 50 μM of one of the 3-indolyl furanoids.

Claim (Index 19):
The pharmaceutical composition as claimed in  claim 3 , wherein said composition is administered intraperitoneally at a dose level ranging between 5 to 25 mg per kg body weight.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 88.0
- Lexical Diversity: 1.85859
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13822463', '16098289', '15886192', '11548501', '15261659']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7459853362449064
- 35 USC 102 Novelty (BERT): 0.5142592938343084
- Combined Prediction Score: 0.7228127320038465
- Mean Citation Score: 231.043664
- Max Citation Score: 246.58041
- Similarity Product: 162.26282685862003

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test