PATENT CLAIM ANALYSIS

Application Number: 15755168
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "006110"]

Abstract:
The invention relates to method for detecting HPV-induced high-grade precancerous lesions, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers, said method comprising detection of hypermethylation in the ZIC1 and/or GHSR gene in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers. The invention further comprises the use of the ZIC1 and/or GHSR gene in such a method and a testkit for the detection of ZIC1 and/or GHSR methylation.

Claim (Index 9):
The method of  claim 1 , wherein a methylation specific PCR is performed, followed by specific PCR reactions that target CpG rich sequences; and wherein said methylation specific PCR is based on bisulfite modification of DNA.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 88.0
- Lexical Diversity: 2.02273
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14434866', '12937981', '10551584', '14180239', '14013272']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6854112196180008
- 35 USC 102 Novelty (BERT): 0.6072572083372129
- Combined Prediction Score: 0.677595818489922
- Mean Citation Score: 418.552248
- Max Citation Score: 604.4880400000002
- Similarity Product: 471.10122205625066

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test