PATENT CLAIM ANALYSIS

Application Number: 15933098
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["514", "210010"]

Abstract:
The present invention is directed toward novel compounds and novel methods of use of said compounds of the formula (I), useful as nucleocapsid assembly inhibitors for the treatment of viruses, especially but not exclusively, including pregenomic RNA encapsidation inhibitors of HBV for the treatment of Hepatitis B virus (HBV) infection and related conditions. including hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8  are defined herein.

Claim (Index 62):
A compound of Formula (I), or an enantiomer, diastereoisomer, salt, hydrate, or solvate thereof: wherein:\n A is selected from the group consisting of S(\u2550O) 2  and C(\u2550O); \n R 1  is selected from the group consisting of optionally substituted C 1-6  alkyl, optionally substituted C 3-7  cycloalkyl, optionally substituted C 2-8  alkenyl, optionally substituted C 2-8  alkynyl, optionally substituted 3-7 membered cycloheteroalkyl, and optionally substituted heterocyclic; \n R 2  is selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 3-7  cycloalkyl, and optionally substituted heterocyclic; or\n R 1  and R 2  are taken together with the atoms to which they are bound to form optionally substituted 3-membered to 10-membered heterocyclyl; \n \n R 3  is selected from the group consisting of optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted alkylheteroaryl; \n R 4  is selected from the group consisting of hydrogen and optionally substituted C 1-6  alkyl; \n R 5  is selected from the group consisting of hydrogen, halogen, optionally substituted C 1-6  alkyl, optionally substituted C 1-6  haloalkyl, OR 9 , cyano, and N(R 9 ) 2 ; \n R 6  is H and R 8  is F, or R 6  is F and R 8  is H; \n R 7  is selected from the group consisting of hydrogen, halogen, optionally substituted C 1-6  alkyl, OR 9 , cyano, and N(R 9 ) 2 ; \n R 9  is independently at each occurrence selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 3-7  cycloalkyl, optionally substituted benzyl, and optionally substituted heterocyclyl; \n provided that, when A is SO 2 , then the compound is not selected from any of the groups (a) through (d): \n (a) R 3  is optionally substituted phenyl, and R 1  or R 2 , either individually or when taken together, contain a hydroxyl group; or (b) R 3  is optionally substituted phenyl, and N(R 1 )(R 2 ) is optionally substituted piperazine, or (c) R 3  is optionally substituted aryl or alkaryl, and N(R 1 )(R 2 ) is or (d) R 3  is unsubstituted or monosubstituted aryl, unsubstituted or monosubstituted aralkyl, or unsubstituted or monosubstituted heteroaryl, and R 1  and R 2  are taken together with the atoms to which they are bound to form optionally substituted 6- to 12-membered heterocyclic.

Metadata:
- Claim Count in Document: 95.0
- Percentile: 90.0
- Lexical Diversity: 1.63077
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14759385', '14782308', '15886766', '13126490', '14423963']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7985215661064914
- 35 USC 102 Novelty (BERT): 0.5382542944137898
- Combined Prediction Score: 0.7724948389372213
- Mean Citation Score: 298.000968
- Max Citation Score: 378.1172
- Similarity Product: 344.87908187177186

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test