PATENT CLAIM ANALYSIS

Application Number: 15911797
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "316000"]

Abstract:
The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.

Claim (Index 2):
A method for reducing elevated intraocular pressure in a mammal comprising administering an effective amount of a compound according to Formula (I), or a pharmaceutically acceptable salt thereof: wherein: R 1  is selected from H and \u2014C 1-3 alkyl; R 2  and R 3  are each independently selected from H and halogen; R 4  is selected from H, \u2014C 1-3 alkyl, \u2014O\u2014C 1-3 alkyl, \u2014O\u2014C 3-4 cycloalkyl, \u2014O\u2014(CH 2 ) p -oxetanyl, and \u2014O\u2014(CH 2 ) p -tetrahydrofuranyl; X and Y are each CH; or if X is N, then Y is CH; or if Y is N then X is CH; A is absent or O; R 5  is selected from \u2014C 1-4  alkyl, \u2014C 3-4  cycloalkyl, \u2014(CH 2 ) n CN, \u2014(CH 2 ) n CF 3 , \u2014(CH 2 ) m -tetrahydrofuranyl, \u2014(CH 2 ) m -oxetanyl, \u2014C 2-5  alkyl-OH, \u2014C 2-5  alkyl-OCH 3  and \u2014CO\u2014R 6 ; R 6  is selected from \u2014C 1-6  alkyl and \u2014C 3-6  cycloalkyl, optionally substituted by \u2014OH, \u2014OCH 3 , \u2014CN, COOH or \u2014F, or R 6  is \u2014(CH 2 ) m -tetrahydrofuranyl or \u2014(CH 2 ) m -oxetanyl, or R6 is a (CH 2 ) m -4 to 5-membered heterocycle; n is 1 or 2; m is 0 or 1; and p is 0 or 1, to a mammal in need thereof.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 90.0
- Lexical Diversity: 1.22581
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15509895', '15320810', '16063059', '15320815', '12711854']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7720630618911077
- 35 USC 102 Novelty (BERT): 0.5958812690437644
- Combined Prediction Score: 0.7544448826063734
- Mean Citation Score: 411.9334
- Max Citation Score: 555.7074
- Similarity Product: 417.25175413019656

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test