PATENT CLAIM ANALYSIS

Application Number: 15303172
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2017-02
Patent Classification: ["514", "001100"]

Abstract:
Disclosed are peptides that contain up to about 35 amino acids, including a plurality of aromatic amino acid residues and either (i) an amino acid residue that is phosphorylated or sulfated, or (ii) an amino acid comprising an ester-moiety linked via peptide bond, or both (i) and (ii), wherein the peptide is capable of self-assembly to form nanofibrils in the presence of an enzyme that hydrolyzes the phosphate group, the sulfate group, or the ester-moiety. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for in vitro and in vivo cellular imaging, treating cancerous conditions, collecting a secretome from a cell upon which the pericellular hydrogels/nanofibrils form, and screening the collected secretome.

Claim (Index 41):
A method for forming a nanofibril network on or near the surface of target cells, the method comprising:\n contacting a target cell that expresses a cell surface-bound enzyme having hydrolytic activity, secretes an enzyme having hydrolytic activity, or both, with the peptide according to any one of  claims 1  to  31  or the pharmaceutical composition according to any one of  claims 36  to  40 , wherein said contacting is effective to hydrolyze the phosphate group, the sulfate group, or the ester moiety and cause in situ self-assembly of the peptides to form a nanofibril network on or near the surface of the target cell.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 90.0
- Lexical Diversity: 1.79167
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13132580', '09938623', '13857752', '13857754', '15402795']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7476916861755656
- 35 USC 102 Novelty (BERT): 0.4901321222492551
- Combined Prediction Score: 0.7219357297829345
- Mean Citation Score: 207.392704
- Max Citation Score: 211.92407000000003
- Similarity Product: 151.64919158959094

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test