PATENT CLAIM ANALYSIS

Application Number: 16326189
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["424", "206100"]

Abstract:
The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Claim (Index 1):
A compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein, U is N or CR 5 ; each of R 1 , R 2 , R 3 , R 4  and R 5  is independently H, D, F, Cl, Br, CN, NO 2 , \u2014C(\u2550O)R a , \u2014C(\u2550O)OR b , \u2014C(\u2550O)NR c R d , OR b , \u2014NR c R d , R b O\u2014C 1-4  alkylene, R d R c N\u2014C 1-4  alkylene, C 1-6  alkyl, C 2-6  alkenyl or C 2-6  alkynyl, and wherein each of the C 1-6  alkyl, C 2-6  alkenyl and C 2-6  alkynyl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, Br, CN, OR b , \u2014NR c R d , C 1-6  alkyl, C 1-6  haloalkyl, R b O\u2014C 1-4  alkylene or R d R c N\u2014C 1-4  alkylene; R 6  is OR b , C 2-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-12  carbocyclyl, C 3-12  carbocyclyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 16-membered heteroaryl or (5- to 16-membered heteroaryl)-C 1-4  alkylene, and wherein each of the C 2-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-12  carbocyclyl, C 3-12  carbocyclyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 16-membered heteroaryl and (5- to 16-membered heteroaryl)-C 1-4  alkylene is independently unsubstituted or substituted with 1, 2, 3, 4 or 5 R\u2032; R 7  is H, D, F, Cl, Br, CN, NO 2 , \u2014C(\u2550O)R a , \u2014C(\u2550O)OR b , \u2014C(\u2550O)NR c R d , OR b , \u2014NR c R d , R b O\u2014C 1-4  alkylene, R d R c N\u2014C 1-4  alkylene, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-12  cycloalkyl, C 3-12  cycloalkyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 10-membered heteroaryl or (5- to 10-membered heteroaryl)-C 1-4  alkylene, and wherein each of the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-12  cycloalkyl, C 3-12  cycloalkyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 10-membered heteroaryl or (5- to 10-membered heteroaryl)-C 1-4  alkylene is independently unsubstituted or substituted with 1, 2, 3, 4 or 5 R\u2032; or, R 6  and R 7 , together with the carbon atoms to which they are attached, form a C 3-12  carbocyclic ring, 3- to 12-membered heterocyclic ring, C 6-10  aromatic ring or 5- to 10-membered heteroaromatic ring, and wherein each of the C 3-12  carbocyclic ring, 3- to 12-membered heterocyclic ring, C 6-10  aromatic ring and 5- to 10-membered heteroaromatic ring is independently unsubstituted or substituted with 1, 2, 3, 4 or 5 R\u2032; each R\u2032 is independently D, F, Cl, Br, CN, NO 2 , OR b , \u2014NR c R d , R b O\u2014C 1-4  alkylene, R d R c N\u2014C 1-4  alkylene, \u2014C(\u2550O)R a , \u2014C(\u2550O)OR b , \u2014C(\u2550O)NR c R d , C 1-12  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-4  alkylene, 3- to 8-membered heterocyclyl, (3- to 8-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 8-membered heteroaryl or (5- to 8-membered heteroaryl)-C 1-4  alkylene, and wherein each of the C 1-12  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-4  alkylene, 3- to 8-membered heterocyclyl, (3- to 8-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 8-membered heteroaryl and (5- to 8-membered heteroaryl)-C 1-4  alkylene is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, Br, CN, NO 2 , OR b , \u2014NR c R d , C 1-6  alkyl, C 1-6  haloalkyl, R b O\u2014C 1-4  alkylene or R d R c N\u2014C 1-4  alkylene; R 8  is H, D or C 1-6  alkyl, and wherein C 1-6  alkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, Br, CN, NO 2  or OR b ; W is C 1-8  alkyl, C 3-12  carbocyclyl or 3- to 12-membered heterocyclyl, and wherein C 1-8  alkyl, C 3-12  carbocyclyl and 3- to 12-membered heterocyclyl is independently unsubstituted or substituted with 1, 2, 3 or 4 R w ; each R w  is independently D, F, Cl, Br, CN, NO 2 , oxo (\u2550O), \u2014C(\u2550O)R a , \u2014C(\u2550O)OR b , \u2014NR e C(\u2550O)R a , \u2014NR e C(\u2550O)NR c R d , \u2014S(\u2550O) 2 R f , \u2014S(\u2550O) 2 NR e C(\u2550O)R a , \u2014S(\u2550O) 2 NR c R d , (R b O) 2 P(\u2550O)\u2014C 0-2  alkylene, OR b , R b O\u2014C 1-2  alkylene, C 1-6  alkyl or 5- to 6-membered heteroaryl, and wherein each of the C 1-6  alkyl and 5- to 6-membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, Br, CN, N 3 , oxo (\u2550O), NO 2 , OR b , C 1-6  alkyl or C 1-6  haloalkyl; each R a , R b , R c , R d , R e  and R f  is independently H, D, C 1-6  haloalkyl, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  carbocyclyl, C 3-6  carbocyclyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 10-membered heteroaryl, (5- to 10-membered heteroaryl)-C 1-4  alkylene; or, R c  and R d , together with the nitrogen atom to which they are attached, form 3- to 8-membered heterocyclyl or 5- to 8-membered heteroaryl, and wherein each of the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  carbocyclyl, C 3-6  carbocyclyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 10-membered heteroaryl, (5- to 10-membered heteroaryl)-C 1-4  alkylene, 3- to 8-membered heterocyclyl and 5- to 8-membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, OH, NH 2 , C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy or C 1-6  alkylamino.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 99.0
- Lexical Diversity: 1.48148
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16327335', '12905268', '14396754', '12728153', '15314932']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7827881175094505
- 35 USC 102 Novelty (BERT): 0.5846713905615033
- Combined Prediction Score: 0.7629764448146558
- Mean Citation Score: 375.97671
- Max Citation Score: 482.20844000000005
- Similarity Product: 456.5119212963128

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test