PATENT CLAIM ANALYSIS

Application Number: 15864309
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["424", "204100"]

Abstract:
A method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a gene editing composition directed toward at least one target sequence in the JCV genome, cleaving the target sequence in the JCV genome, disrupting the JCV genome, eliminating the JCV infection, eliminating the risk of JCV activation, and treating the subject with an immunosuppressive therapy. A pharmaceutical composition including at least one isolated nucleic acid sequence encoding a CRISPR-associated endonuclease and at least one gRNA having a spacer sequence complementary to a target sequence in a JCV DNA, the isolated nucleic acid sequences being included in at least one expression vector. Pharmaceutical compositions including at least one isolated nucleic acid sequence encoding at least one TALEN, at least one ZFN, and gene editing composition of C2c1, C2c3, TevCas9, Archaea Cas9, CasY.1-CasY.6, CasX, or argonaute protein, which target at least one nucleotide sequence of the JCV genome.

Claim (Index 10):
The method according to  claim 1 , wherein the gene editing composition is defined as a pharmaceutical composition including at least one pair of zinc finger nucleases (ZFN), which targets at least one nucleotide sequence of the JCV genome.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 86.0
- Lexical Diversity: 2.41096
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14838057', '14725943', '14790748', '15250514', '15449181']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7652877889671414
- 35 USC 102 Novelty (BERT): 0.5315697094548676
- Combined Prediction Score: 0.741915981015914
- Mean Citation Score: 313.150294
- Max Citation Score: 356.91992
- Similarity Product: 235.8000865177536

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test