PATENT CLAIM ANALYSIS

Application Number: 16023496
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["436", "086000"]

Abstract:
The invention pertains to diagnosis and treatment of ovarian cancer (OC), cervical cancer (CC), or colorectal cancer (CRC). One embodiment of the invention provides a method of identifying OC, CC, or CRC based on the level of RHAMM in the urine of a subject. Another embodiment of the invention provides a method of identifying OC based on the level of RHAMM in the urine and CA 125  in the blood of a subject. The invention also pertains to monitoring the efficacy of a treatment of OC, CC, or CRC based on the level of RHAMM protein in the urine and/or the level of CA 125  in the blood. Another embodiment of the invention provides devices and reagents to assay RHAMM in a urine sample and optionally, assay CA 125  in a blood sample.

Claim (Index 4):
A method for monitoring the effect of a treatment for OC, CC, or CRC in a subject, the method comprising the steps of:\n (a) determining the level of RHAMM in:\n i) a pre-treatment test urine sample obtained from the subject before the treatment, \n ii) a post-treatment test urine sample obtained from the subject after the treatment, and \n ii) optionally, a control sample; \n (b) optionally, obtaining a reference value for the level of RHAMM before or after the treatment; and (c) identifying the treatment for OC, CC, or CRC as effective based on the level of RHAMM in the post-treatment test urine sample compared to the level of RHAMM in the pre-treatment test urine sample and optionally continuing the treatment for OC, CC, or CRC, or (d) identifying the treatment for OC, CC, or CRC as ineffective based on the level of RHAMM in the post-treatment test urine sample compared to the level of RHAMM in the pre-treatment test urine sample and optionally modifying the treatment for OC, CC, or CRC.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 94.0
- Lexical Diversity: 3.14583
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11704408', '12066564', '11866475', '15577631', '11037889']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6916501234883456
- 35 USC 102 Novelty (BERT): 0.4892280779124693
- Combined Prediction Score: 0.671407918930758
- Mean Citation Score: 207.41876
- Max Citation Score: 242.74283
- Similarity Product: 165.39435913273454

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test