PATENT CLAIM ANALYSIS

Application Number: 15986577
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "364000"]

Abstract:
Use of glu-tubulin as a biomarker for predicting the response to a compound, preferably resistance of a disease such as cancer in a subject to said compound, wherein the compound is a furazanobenzimidazole compound of general formula (I).

Claim (Index 38):
A method for predicting the response to treatment of a disease in a patient subject by administration of a compound of general formula I wherein R represents phenyl, thienyl or pyridinyl wherein phenyl is optionally substituted by one or two substituents independently selected from alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, cyano, halogen, and nitro; and wherein two adjacent substituents are methylenedioxy; and wherein pyridinyl is optionally substituted by lower alkoxy, amino or halogen; wherein Y is oxygen or nitrogen substituted by hydroxy or lower alkoxy; or when R1 is phenyl or pyridinyl, X is additionally oxygen, R 1  represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl; R 2 , R 3  and R 6  represent hydrogen; R 4  and R 5 , independently of each other, represent hydrogen, lower alkyl or lower alkoxy; or R 4  and R 5  together represent methylenedioxy; or pharmaceutically acceptable derivatives thereof, and wherein said prefix lower denotes a radical having up to 7 carbon atoms, said method comprising the steps of: a) measuring the level of the glu-tubulin, proteins in a sample obtained from a patient to obtain a value or values representing this level; and b) comparing the value or values of the levels from step a) with a standard value or a set of standard values which comparison is predictive of responsiveness to compounds of formula I.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 1.43333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13980208', '13983887', '15294157', '13979955', '14005680']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8446437410761849
- 35 USC 102 Novelty (BERT): 0.6942468781711294
- Combined Prediction Score: 0.8296040547856794
- Mean Citation Score: 686.2745000000001
- Max Citation Score: 729.4968
- Similarity Product: 700.9813515838623

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test