PATENT CLAIM ANALYSIS

Application Number: 15773653
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["424", "186100"]

Abstract:
Respiratory syncytial virus (RSV) infection may lead to severe respiratory illness in young children. Thus, there is a need for a live attenuated vaccine, which would mimic the natural course of infection without causing illness; however, restricting viral replication also reduces the immune response. Reported herein is a method of vaccination using a single dose of a recombinant RSV lacking the M2-2 protein that surprisingly induced a stronger immune response to RSV than previous vaccine candidates despite being more restricted in replication.

Claim (Index 28):
A method for vaccinating a human subject against respiratory syncytial virus (RSV) infection, comprising administering to the subject a composition comprising an RSV particle that comprises an RSV genome or antigenome,\n wherein the subject less than about 24 months of age, wherein the composition is administered intranasally in a single dose, and wherein the RSV genome or antigenome comprises:\n i) a functional deletion in the M2-2 ORF corresponding to a deletion of nucleotides 8201-8434 in Genbank Accession No. M74568; \n ii) presence of, corresponding to the nucleotides in Genbank Accession No. M74568, C4488 in the SH gene, C4491 in the SH gene, A4494 in the SH gene, A4496 in the SH gene, G4497 in the SH gene, and a nucleotide sequence corresponding to nucleotides 4498-4609 in the non-translated region of the SH gene; \n iii) presence of G at a nucleotide position corresponding to position 1209 in Genbank Accession No. M74568 encoding an Alanine at position 24 in the N protein; \n iv) presence of G at a nucleotide position corresponding to position 779 in Genbank Accession No. M74568 encoding an Arginine at position 51 in the NS2 protein; \n v) presence of nucleotides corresponding to the nucleotides in Genbank Accession No. M74568 selected from the group consisting of: A1138, G1139, A5611, A5615, G5639, T7481 and A7559; \n vi) presence of nucleotides corresponding to the nucleotides in Genbank Accession No. M74568 selected from the group consisting of: C404 in the NS1 gene, G1181 in the N gene, A1939 A1937 in the N gene, C6215 in the F gene, C6221 in the F gene, T6386 in the F gene, C7214 in the F gene, G7701 in the M2 gene; T8160 in the M2-2 gene, T8166 in the M2-2 gene, T8178 in the M2-2 gene, A8197 in the M2-2 gene, G8198 in the M2-2 gene, T 10514 in the L gene, A 13633 in the L gene, and T 13900 in the L gene and \n vii) presence of T at a nucleotide position corresponding to position 1099 in Genbank Accession No. M74568.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 93.0
- Lexical Diversity: 1.35821
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16061314', '10934003', '09887469', '10722000', '10754895']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7727135087378403
- 35 USC 102 Novelty (BERT): 0.5526727272626115
- Combined Prediction Score: 0.7507094305903175
- Mean Citation Score: 420.56412
- Max Citation Score: 433.09232
- Similarity Product: 321.26148544556617

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test