PATENT CLAIM ANALYSIS

Application Number: 15746597
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "210180"]

Abstract:
The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβ R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Claim (Index 6):
A compound selected from\n N-[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-(difluoromethyl)-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl)}pyridin-4-amine, 3-chloro-N-[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-chloro-N-[2-(5-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine 6-{4-[(3-fluoropyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}pyridine-2-carboxamide, 3-chloro-N-[2-(6-methylpyrazin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 2-chloro-N-{2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, N-(6-{4-[(pyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}pyridin-2-yl)methanesulfonamide, N-(6-(4-((3-fluoropyridin-4-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)pyridin-2-yl)acetamide, 3-fluoro-N-[2-(1-methyl-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[4-({2-[6-(difluoromethyl)-5-fluoromethyl)-5-fluoropyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, 3-fluoro-N-[2-(4-methyl-1,3-thiazol-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, 3-fluoro-N-[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-(difluoromethyl)-N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[2-(6-methoxypyridin-2-yl)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-(3-fluoropyridin-4-yl)-2-(4-(trifluoromethyl)thiazol-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine, N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)amino)pyridin-2-yl)acetamide, N-(4-{[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)acetamide, N-[3-fluoro-4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, N-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}methanesulfonamide, N-{2-[6-(difluoromethyl)pyridin-2-yl]-5-[(4,4-difluoropiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, N-[4-({5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, N-{5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, 3-fluoro-N-{5-[(4-methylpiperazin-1-yl)methyl]-2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, N-{5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, 1-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}ethane-1,2-diol, 6-ethyl-N-(3-fluoropyridin-4-yl)-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine, 2-[4-(dimethylamino)piperidin-1-yl]-1-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}ethan-1-ol, 2-(6-methoxypyridin-2-yl)-N-(pyridin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine, 1-(6-{4-[(3-fluoropyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}pyridin-2-yl)ethan-1-ol, N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]-2-(pyrrolidin-1-yl)acetamide, 2-N-[2-(4,4-difluoropiperidin-1-yl)ethyl]-4-N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridine-2,4-diamine, N-[2-(1,1-dioxo-1,4-thiomorpholin-4-yl)ethyl]-4-{[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-(3-(1,1-dioxidothiomorpholino)propyl)-4-((2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)amino)nicotinamide, N-[3-(pyrrolidin-1-yl)propyl]-4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl)}amino)pyridine-3-carboxamide, N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-{[3-(morpholin-4-yl)propoxy]methyl}pyridin-4-amine, 2-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propan-2-ol, N-{6-[(4,4-difluoropiperidin-1-yl)methyl]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, 3-fluoro-N-[7-fluoro-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[6-ethyl-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-fluoropyridin-4-amine, 3-fluoro-N-[2-(6-methoxypyridin-2-yl)-6-[4-(4-methylpiperazin-1-yl)butyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(6-methoxypyridin-2-yl)-6-[2-(4-methylpiperazin-1-yl)ethyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(6-methoxypyridin-2-yl)-5-[2-(pyrrolidin-1-yl)ethoxy]pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 2-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}ethan-1-ol, N-(4-{[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-3-yl)acetamide, 2-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}propan-2-ol, N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, -(6-methylpyridin-2-yl)-4-[(pyridin-4-yl)amino]-N-[3-(pyrrolidin-1-yl)propyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 3-[4-(dimethylamino)butoxy]-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 4-[(3-fluoropyridin-4-yl)amino]-2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazine-7-carboxylic acid, 2-(6-aminopyridin-2-yl)-N-(3-fluoropyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine, 3-chloro-N-[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-chloro-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-chloro-N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3,5-difluoro-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(4-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[2-(4-chloropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-fluoropyridin-4-amine, N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyrimidin-4-amine, 3-fluoro-N-[2-(5-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-{2-[6-(difluoromethyl)-5-fluoropyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyrimidin-4-amine, Methyl N-(4-{[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)carbamate, N-[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-chloro-N-[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(6-methylpyrazin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-ethyl-1-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}urea, Methyl N-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}carbamate, 3-fluoro-N-[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-[3-(morpholin-4-yl)propoxy]-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl)}pyridin-4-amine, 75 N-{5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, N-(6-{4-[(3-fluoropyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}pyridin-2-yl)methanesulfonamide, N-{2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, 3-(prop-2-en-1-yloxy)-N-[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-chloro-N-{2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 3-chloro-N-[2-(1-methyl-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 2-chloro-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, 3-fluoro-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 3-chloro-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 3-chloro-N-[2-(4-methyl-1,3-thiazol-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[2-(4-methyl-1,3-thiazol-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(1H-pyrrol-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-(6-{4-[(3-chloropyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}pyridin-2-yl)methanesulfonamide, N-[5-chloro-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-2-methylpyridin-4-amine, 2-chloro-N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 2-fluoro-N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 4-N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridine-3,4-diamine, 2-fluoro-N-[2-(6-methoxypyridin-2-yl)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-(4-{[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)acetamide, 4-{[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-2-(morpholin-4-yl)pyridin-4-amine, 3-fluoro-N-{2-[2-(trifluoromethyl)pyrimidin-4-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 3-fluoro-N-[2-(2-methoxypyrimidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[2-(6-ethoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-fluoropyridin-4-amine, 4-N-(3-fluoropyridin-4-yl)-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazine-4,6-diamine, N-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}acetamide, N-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}morpholine-4-carboxamide, N-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl)}-2-(morpholin-4-yl)acetamide, N-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}cyclopropanesulfonamide, tert-butyl N-[({4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}carbamoyl)methyl]carbamate, 2-amino-N-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}acetamide N-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}-2-methanesulfonamidoacetamide, N-{4-[(3-fluoropyridin-4-yl)amino]-2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}-N-methanesulfonylmethanesulfonamide, 3-fluoro-N-[2-(6-methoxypyridin-2-yl)-5-[2-(4-methylpiperazin-1-yl)ethyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(6-methoxypyridin-2-yl)-5-[2-(morpholin-4-yl)ethyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-{5-[2-(4-aminopiperidin-1-yl)ethyl]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, N-{2-[6-(difluoromethyl)pyridin-2-yl]-5-[(4-methylpiperazin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, 1-[({2-[6-(difluoromethyl)pyridin-2-yl]-4-[(3-fluoropyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]-2-methylpropan-2-ol, N-{4-[(5-{[(2-hydroxy-2-methylpropyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]pyridin-2-yl}acetamide, 1-[({4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]-2-methylpropan-2-ol, 3-fluoro-N-[2-(6-methoxypyridin-2-yl)-5-({[2-(pyrrolidin-1-yl)ethyl]amino}methyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, (3R)-3-fluoro-4-[({4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]-2-methylbutan-2-ol, 3-fluoro-N-[2-(6-methoxypyridin-2-yl)-5-[(4-methylpiperazin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-{2-[6-(difluoromethyl)pyridin-2-yl]-5-[(4-methylpiperazin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, N-{5-[(4,4-difluoropiperidin-1-yl)methyl]-2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-fluoropyridin-4-amine, 1-[({4-[(3-fluoropyridin-4-yl)amino]-2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]-2-methylpropan-2-ol, 1-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]-2-methylpropan-2-ol, (3R,4R)-4-amino-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)piperidin-3-ol, 3-fluoro-N-{5-[(4-methylpiperazin-1-yl)methyl]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 1-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-(4-methylpiperazin-1-yl)ethan-1-ol, 2-(4,4-difluoropiperidin-1-yl)-1-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}ethan-1-ol, 1-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-{[2-(piperidin-1-yl)ethyl]amino}ethan-1-ol, 4-{2-[(2-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2-hydroxyethyl)amino]ethyl}-1,4-thiomorpholine-1,1-dione, 1-{2-[(4-{[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)amino]ethyl}piperidin-4-ol, 1-[(4-{[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)amino]-2-methylpropan-2-ol, 4-[(4-{[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)amino]-2-methylbutan-2-ol, 2-N-[3-(dimethylamino)propyl]-4-N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridine-2,4-diamine, 1-{2-[(4-{[2-(6-methoxypyridin-2-yl)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)amino]ethyl}piperidin-4-ol, 4-N-[2-(6-methoxypyridin-2-yl)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]-2-N-[2-(morpholin-4-yl)ethyl]pyridine-2,4-diamine, 1-[(4-{[2-(6-methoxypyridin-2-yl)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)amino]-2-methylpropan-2-ol, 4-N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-2-N-[2-(morpholin-4-yl)ethyl]pyridine-2,4-diamine, N-[3-(1,1-dioxo-1,4-thiomorpholin-4-yl)propyl]-4-{[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, 4-{[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-[2-(piperidin-1-yl)ethyl]pyridine-3-carboxamide, 4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide, N-[2-(diethyl amino)ethyl]-4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-[2-(piperidin-1-yl)ethyl]-4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, tert-butyl 4-{2-[(4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-3-yl)formamido]ethyl}piperazine-1-carboxylate, N-{2-[cis-2,6-dimethylmorpholin-4-yl]ethyl}-4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-[2-(1,1-dioxo-1,4-thiomorpholin-4-yl)ethyl]-4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-[3-(1,1-dioxo-1,4-thiomorpholin-4-yl)propyl]-4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-[3-(2-oxopyrrolidin-1-yl)propyl]-4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, 4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-[3-(pyrrolidin-1-yl)propyl]pyridine-3-carboxamide, N-[2-(piperazin-1-yl)ethyl]-4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, 4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide, N-[2-(1,1-dioxo-1,4-thiomorpholin-4-yl)ethyl]-4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-[(4-hydroxy-1-methylpiperidin-4-yl)methyl]-4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, 4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-[2-(piperidin-1-yl)ethyl]pyridine-3-carboxamide, N-(2-hydroxy-2-methylpropyl)-4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-(1-hydroxy-2-methylpropan-2-yl)-4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-[(2 S)-2,3-dihydroxypropyl]-4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-(3-hydroxypropyl)-4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-[3-(4-methylpiperazin-1-yl)propyl]-4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, 4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-(oxolan-3-yl)pyridine-3-carboxamide, N-[2-(dimethylamino)ethyl]-N-methyl-4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridine-3-carboxamide, N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-(morpholine-4-carbonyl)pyridin-4-amine, 4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-(oxan-4-yl)pyridine-3-carboxamide, 4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-(oxetan-3-yl)pyridine-3-carboxamide, 4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-(propan-2-yl)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[2-(1,1-dioxo-1,4-thiomorpholin-4-yl)ethyl]pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[3-(1,1-dioxo-1,4-thiomorpholin-4-yl)propyl]pyridine-3-carboxamide, N-[3-(morpholin-4-yl)propyl]-4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carboxamide, N-[2-(pyrrolidin-1-yl)ethyl]-4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carboxamide, N-[2-(piperidin-1-yl)ethyl]-4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(3-ethoxypropyl)pyridine-3-carboxamide, N-[2-(tert-butoxy)ethyl]-4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[2-(2-hydroxyethoxy)ethyl]pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[(1S,2S)-2-hydroxycyclohexyl]pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[3-(4-methylpiperazin-1-yl)propyl]pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(oxolan-3-yl)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(oxan-4-yl)pyridine-3-carboxamide, N-[2-(1,1-dioxo-1,4-thiomorpholin-4-yl)ethyl]-4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[(1R,2R)-2-hydroxycyclohexyl]pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(pyridin-2-ylmethyl)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[(5-ethyl-1,3,4-oxadiazol-2-yl)methyl]pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(1,3-thiazol-2-ylmethyl)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-propylpyridine-3-carboxamide, 1-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carbonyl]-4-phenylpiperidin-4-ol, N-{2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-(pyrrolidine-1-carbonyl)pyridin-4-amine, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(3-hydroxy-3-methylbutyl)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(2-hydroxy-2-methylpropyl)pyridine-3-carboxamide, 3-(azetidine-1-carbonyl)-N-{2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl)}pyridin-4-amine, Ethyl 2-{[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-3-yl]formamido}acetate, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(1H-1,2,4-triazol-3-ylmethyl)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(2-hydroxyethyl)pyridine-3-carboxamide, N-cyclobutyl-4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(propan-2-yl)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(1,3-oxazol-4-ylmethyl)pyridine-3-carboxamide, tert-butyl 2-{[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-3-yl]formamido}acetate, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(1H-pyrazol-5-ylmethyl)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[(1R,2S)-2-hydroxycyclopentyl]pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[(1S,2S)-2-hydroxycyclopentyl]pyridine-3-carboxamide, 1-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carbonyl]piperidin-4-ol, N-(4,4-difluorocyclohexyl)-4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carboxamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-(3,3,3-trifluoropropyl)pyridine-3-carboxamide, N-{2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}-3-(4,4-difluoropiperidine-1-carbonyl)pyridin-4-amine, Ethyl 3-{[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-3-yl]formamido}propanoate, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-{[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}pyridine-3-carboxamide, (4-{[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-3-yl)methanol, 1-[({4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}methyl)amino]-2-methylpropan-2-ol, (3R)-3-fluoro-4-[({4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}methyl)amino]-2-methylbutan-2-ol, 4-{3-[({4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl)}methyl)amino]propyl}-1,4-thiomorpholine-1,1-dione, N-[6-ethenyl-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-fluoropyridin-4-amine, (3E)-4-{4-[(3-fluoropyridin-4-yl)amino]-2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}but-3-en-1-ol, N-(4-{[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-3-yl)-2-(morpholin-4-yl)acetamide, N-[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[2-(6-methoxypyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-{2-[2-(methylsulfanyl)pyrimidin-4-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, Ethyl 2-(6-methylpyridin-2-yl)-4-[(pyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate, 2-(6-methylpyridin-2-yl)-N-phenyl-4-[(pyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, N,N-dimethyl-2-(6-methylpyridin-2-yl)-4-[(pyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 2-(6-methylpyridin-2-yl)-4-[(pyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, N-methyl-2-(6-methylpyridin-2-yl)-4-[(pyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-{[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}-N-[3-(pyrrolidin-1-yl)propyl]pyridine-3-carboxamide, N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-[3-(morpholin-4-yl)propoxy]pyridin-4-amine, 4-({2-[6-(difluoromethyl)-5-fluoropyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carboxamide, N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-fluoropyridin-2-yl]acetamide, N-[5-fluoro-4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, N-(4-{[2-(5-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)acetamide, 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-3-carboxamide, N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-3-fluoropyridin-2-yl]acetamide, 2-(1H-pyrazol-3-yl)-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 2-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)piperazin-1-yl]ethan-1-ol, (3S)-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)pyrrolidin-3-ol, (3R)-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)pyrrolidin-3-ol, 3-fluoro-N-[2-(5-fluoropyridin-2-yl)-5-[(4-methylpiperazin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 1-({[2-(5-fluoropyridin-2-yl)-4-[(3-fluoropyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl}amino)-2-methylpropan-2-ol, 4-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]cyclohexan-1-ol, (5R,7S)-3-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]adamantan-1-ol, 3-fluoro-N-(5-{[(piperidin-4-ylmethyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, 1-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]propan-2-ol, 1-{2-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]ethyl}cyclopentan-1-ol, 3-fluoro-N-(5-{[(1-methyl cyclobutyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, 3-fluoro-N-(5-{[(4-methyloxan-4-yl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, 1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)piperidin-4-ol, {1-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]cyclopentyl}methanol, 4-N-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)-1-N,1-N-dimethylcyclohexane-1,4-diamine, 3-fluoro-N-[5-({[3-(morpholin-4-yl)propyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-(5-{[(oxolan-2-ylmethyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, 3-fluoro-N-{2-[5-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 3-fluoro-N-[2-(2-methoxy-1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-{4-[(5-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]pyridin-2-yl}acetamide, (3S)-1-({2-[6-(difluoromethyl)pyridin-2-yl]-4-[(3-fluoropyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)pyrrolidin-3-ol, (3S)-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)pyrrolidin-3-ol, 2-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-4-[(3-fluoropyridin-4-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)piperazin-1-yl]ethan-1-ol, N-{4-[(5-{[(2-hydroxy-2-methylpropyl)amino]methyl}-2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]pyridin-2-yl}acetamide, N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyrimidin-4-amine, 2-fluoro-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 2-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 1-{[(4-{[2-(ethylamino)pyridin-4-yl]amino}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl)methyl]amino}-2-methylpropan-2-ol, 2-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)piperazin-1-yl]ethan-1-ol, 3-fluoro-N-[2-(3-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(3-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(1,3-thiazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, (1R,4R)-1-N-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)cyclohexane-1,4-diamine, 2-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]propane-1,3-diol, 3-fluoro-N-(5-{[(piperidin-2-ylmethyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, N-(5-{[(azetidin-3-ylmethyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-3-fluoropyridin-4-amine, 3-fluoro-N-(5-{[(piperidin-3-yl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, 3-fluoro-N-[2-(pyridin-2-yl)-5-{[(2,2,2-trifluoroethyl)amino]methyl}pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[5-({[2-(piperazin-1-yl)ethyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(pyridin-2-yl)-5-({[2-(pyrrolidin-2-yl)ethyl]amino}methyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-(5-{[(cyclobutylmethyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-3-fluoropyridin-4-amine, 2-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]cyclohexan-1-ol, (2S)-2-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]pentan-1-ol, 4-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]butan-2-ol, 3-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)piperazin-1-yl]phenol, 3-fluoro-N-[2-(pyridin-2-yl)-5-{[4-(pyrimidin-2-yl)piperazin-1-yl]methyl}pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)-4-phenylpiperidin-4-ol, 1-[1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)piperidin-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one, 3-fluoro-N-(5-{[methyl(1-methylpiperidin-4-yl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, N-[5-({[2-(dimethylamino)ethyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-fluoropyridin-4-amine, 3-fluoro-N-[5-({[3-(1H-imidazol-1-yl)propyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-(5-{[(adamantan-1-yl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-3-fluoropyridin-4-amine, 3-fluoro-N-[5-({[3-(4-methylpiperazin-1-yl)propyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[5-({[2-(piperidin-1-yl)ethyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[5-({[(3S)-1-benzylpyrrolidin-3-yl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-fluoropyridin-4-amine, N-(5-{[(3-aminopropyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-3-fluoropyridin-4-amine, (2S)-3-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]propane-1,2-diol, (1R,4R)-4-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]cyclohexan-1-ol, 3-fluoro-N-{2-[6-(trifluoromethoxy)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}pyridin-4-amine, 3-fluoro-N-[5-(morpholin-4-ylmethyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-(4-{[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)acetamide, 4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-2-carbonitrile, N-(4-{[5-(morpholin-4-ylmethyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)acetamide, N-(5-{[(2H-1,3-benzodioxol-5-ylmethyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-3-fluoropyridin-4-amine, N-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)-2-methyl-1,3-benzothiazol-6-amine, (3-{[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]methyl)}oxetan-3-yl)methanol, 3-fluoro-N-[5-({[4-(1,3-oxazol-5-yl)phenyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-(5-{[(5-phenyl-1H-pyrazol-3-yl)amino]methyl)}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, 3-fluoro-N-(5-{[(morpholin-2-ylmethyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, N-[5-({[(2R)-3,3-dimethylbutan-2-yl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-3-fluoropyridin-4-amine, 3-fluoro-N-[2-(pyridin-2-yl)-5-({[2-(pyridin-2-yl)propan-2-yl]amino}methyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[5-({[1-(propan-2-yl)-1H-pyrazol-4-yl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[5-({[2-(1-methylpiperidin-4-yl)ethyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[2-(pyridin-2-yl)-5-({[2-(pyridin-2-yl)ethyl]amino}methyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, 3-fluoro-N-[5-({[(5-methylpyrazin-2-yl)methyl]amino}methyl)-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)-1H-1,2,3-benzotriazol-5-amine, 3-fluoro-N-(5-{[(piperidin-4-yl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, 3-fluoro-N-(5-{[(5-methyl-1,3,4-thiadiazol-2-yl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, (3S,4S)-4-amino-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)piperidin-3-ol, (1R)-2-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)amino]-1-phenylethan-1-ol, N-(5-{[(azetidin-3-yl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)-3-fluoropyridin-4-amine, Methyl N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]carbamate, N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]propanamide, 3-methyl-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl)}amino)pyridin-2-yl]butanamide, 4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-2-carboxamide, 2-(4-methylpiperazin-1-yl)-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, 2-chloro-5-fluoro-N-[2-(5-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]pyridin-4-amine, N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]methanesulfonamide, 2-[4-(2-hydroxyethyl)piperazin-1-yl]-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl)}amino)pyridin-2-yl]acetamide, 2-(4-acetylpiperazin-1-yl)-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, 3,3-dimethyl-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]butanamide, 2-(piperazin-1-yl)-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, N-(5-fluoro-4-{[2-(5-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)acetamide, N-(2-hydroxy-2-methylpropyl)-4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridine-2-carboxamide, 2-[(3S)-3-hydroxypyrrolidin-1-yl]-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, (2S)-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]pyrrolidine-2-carboxamide, 2-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, 3-fluoro-N-(5-{[(1-methylpiperidin-4-yl)oxy]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)pyridin-4-amine, 2-(piperidin-1-yl)-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, 2-[(2-hydroxy-2-methylpropyl)amino]-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, 2-(morpholin-4-yl)-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, N-[4-({2-[5-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, N-(5-fluoro-4-{[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)acetamide, 3-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]propanamide, N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]cyclopropanecarboxamide, 2-methoxy-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide, 4,4,4-trifluoro-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]butanamide, 3-cyano-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]propanamide, N-(5-fluoro-4-{[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)acetamide, 3-(4-hydroxypiperidin-1-yl)-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]propanamide, 3-(3,3-difluoroazetidin-1-yl)-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]propanamide, 2,2-dimethyl-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]propanamide, 3-methoxy-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]propanamide, 3,3,3-trifluoro-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]propanamide, N-(4-{[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino}pyridin-2-yl)cyclopropanecarboxamide, or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

Metadata:
- Claim Count in Document: 36.0
- Percentile: 86.0
- Lexical Diversity: 1.41935
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15747843', '14977709', '13266921', '12085880', '15027585']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7881313148159789
- 35 USC 102 Novelty (BERT): 0.5528627026800558
- Combined Prediction Score: 0.7646044536023866
- Mean Citation Score: 368.039356
- Max Citation Score: 403.93115
- Similarity Product: 313.8060422591329

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test