PATENT CLAIM ANALYSIS

Application Number: 15859949
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["435", "006110"]

Abstract:
The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes' label codes. Methods of making and using such probes are also provided. The probes can be used in diagnostic, prognostic, quality control and screening applications.

Claim (Index 1):
A nucleic acid probe comprising:\n (i) a first label attachment region, comprising a first DNA sequence of about 300 to about 1500 nucleotides in length having a G/C content of about 40% to about 60% and having a regularly repeated base every about 4 to about 25 bases, and comprising at least a first RNA molecule having a regularly repeated base every about 4 to about 25 bases which is hybridized to the first label attachment region, to the first RNA molecule is attached at said regularly repeated base one or more label monomers that emit light constituting a first signal; (ii) a second label attachment region, which is non-overlapping with the first label attachment region, comprising a second DNA sequence of about 300 to about 1500 nucleotides in length having a G/C content of about 40% to about 60% and having a regularly repeated base every about 4 to about 25 bases, and comprising at least a second RNA molecule having a regularly repeated base every about 4 to about 25 bases which is hybridized to the second label attachment region, to the second RNA molecule is attached at said regularly repeated base one or more label monomers that emit light constituting a second signal; (iii) a third label attachment region, which is non-overlapping with the first label attachment region and is non-overlapping with the second label attachment region, comprising a third DNA sequence of about 300 to about 1500 nucleotides in length having a G/C content of about 40% to about 60% and having a regularly repeated base every about 4 to about 25 bases, and comprising at least a third RNA molecule having a regularly repeated base every about 4 to about 25 bases which is hybridized to the third label attachment region, wherein the third RNA molecule is not attached to a label monomer and lacks a signal; and (iv) a first target-specific sequence capable of binding to a target nucleic acid.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.4902
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15160376', '13794424', '13957029', '15082398', '15082436']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6634052443775637
- 35 USC 102 Novelty (BERT): 0.68990845824937
- Combined Prediction Score: 0.6660555657647442
- Mean Citation Score: 579.1731200000003
- Max Citation Score: 708.4253
- Similarity Product: 699.1719329877017

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test