PATENT CLAIM ANALYSIS

Application Number: 16292011
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-06
Patent Classification: ["514", "364000"]

Abstract:
The invention describes compounds that inhibit both HDAC and GSK3β (i.e., HDAC/GSK3β dual inhibitors). The invention further describes compositions containing these HDAC/GSK3β dual inhibitors, as well as methods and kits using these HDAC/GSK3β dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3β to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3β. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.

Claim (Index 1):
A compound of Formula (IV): wherein: L 1  and L 2  are independently a linker; R 1  is an aromatic moiety, alkyl, acyl, cyclyl or heterocyclyl, each of which can be optionally substituted; R 2  is hydrogen, lower alkyl, cyclyl, heterocyclyl, aryl, or heteroaryl, each of which can be optionally substituted; R 3  is absent or an aromatic moiety, which can be optionally substituted; p is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; and wherein -L 1 R 1  is linked to one nitorgen of the thiadiazolidine ring and \u2014(CH 2 ) p \u2014R 3 -L 2 -C(O)NHOR 2  is linked to the other nitorgen of the thiadiazolidine ring.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 99.0
- Lexical Diversity: 1.93878
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15317559', '16012536', '14783344', '14506889', '12022977']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7622250904231489
- 35 USC 102 Novelty (BERT): 0.6248368315578968
- Combined Prediction Score: 0.7484862645366237
- Mean Citation Score: 372.964488
- Max Citation Score: 610.5238
- Similarity Product: 491.7051055646658

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test