PATENT CLAIM ANALYSIS

Application Number: 15917973
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["546", "089000"]

Abstract:
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b  and R 5  are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

Claim (Index 3):
The method according to  claim 1  wherein the 6-membered aryl or heteroaryl is wherein\n A 1  is N or CR 10 ; \n A 2  is N or CR 11 ; \n A 3  is N or CR 12 ; \n A 4  is N or CR 13 ; and \n R 10 , R 11 , R 12  and R 13  independently are H, halogen, C 1 -C 8 (alkyl), (C 1 -C 8 )haloalkyl, C(O)O(C 1 -C 8 )alkyl, C(O)(C 1 -C 8 )alkyl, SO 2 (C 1 -C 8 )alkyl, C 1 -C 8 (alkenyl), (C 1 -C 8 )alkynyl, OR 9 , NHR 9 , NR 9 R 9 , CN, [(C 1 -C 8 )alkylene]OR 9 , [(C 1 -C 8 )alkylene]NHR 9 , [(C 1 -C 8 )alkylene]NR 9 R 9 , C(O)R 8 , C(O)NHR 9 , C(O)NR 9 R 9 , C(O)[(C 1 -C 8 )alkylene]NHR 9 , C(O)[(C 1 -C 8 )alkylene]NR 9 R 9 , CO 2 R 9 , C(S)NHR 9 , C(S)NR 9 R 9 , SR 9 , S(O)R 9 , SO 2 R 9 , SO 2 N(H)(R 9 ), SO 2 NR 9 R 9 , NH(CO)R 8 , NR 9 (CO)R 8 , NH(CO)NHR 9 , NH(CO)NR 9 R 9 , NR 9 (CO)NHR 9 , NR 9 (CO)NR 9 R 9 , P(O)(OH)(OR 9 ), P(O)(OR 9 ) (OR 9 ), aryl, heteroaryl, cycloalkyl, or heterocyclyl.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 90.0
- Lexical Diversity: 1.62712
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15358761', '14772731', '15676726', '15108391', '10420390']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7452231427799008
- 35 USC 102 Novelty (BERT): 0.7456075085673783
- Combined Prediction Score: 0.7452615793586486
- Mean Citation Score: 432.51935
- Max Citation Score: 864.5835599999997
- Similarity Product: 820.794669651904

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test