PATENT CLAIM ANALYSIS

Application Number: 16053550
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["536", "120000"]

Abstract:
The present invention related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing and using the same. The processes of the present invention provide alkylated cyclodextrins with low levels of drug-degrading agents and chloride.

Claim (Index 1):
A process for preparing an alkylated cyclodextrin composition comprising an alkylated cyclodextrin, the process comprising:\n (a) mixing a cyclodextrin with an alkylating agent to form a reaction milieu comprising an alkylated cyclodextrin, one or more unwanted components, and one or more drug-degrading impurities; (b) conducting one or more separations to remove the one or more unwanted components from the reaction milieu to form a partially purified solution comprising the alkylated cyclodextrin and the one or more drug-degrading impurities, wherein the one or more separations are ultrafiltration, diafiltration, centrifugation, extraction, solvent precipitation, or dialysis; (c) preparing a phosphate-free activated carbon having a residual conductivity of 10 \u03bcS or less by a process comprising subjecting activated carbon to a first carbon washing process comprising adding water, soaking the carbon in the water, and draining the water; and (d) treating the partially purified solution with the phosphate-free activated carbon having a residual conductivity of 10 \u03bcS or less and producing the alkylated cyclodextrin, wherein the alkylated cyclodextrin composition has an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.

Metadata:
- Claim Count in Document: 125.0
- Percentile: 96.0
- Lexical Diversity: 1.35714
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14437439', '15351272', '14381568', '12404174', '12613103']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6973207323783177
- 35 USC 102 Novelty (BERT): 0.6489341838564088
- Combined Prediction Score: 0.6924820775261269
- Mean Citation Score: 557.956628
- Max Citation Score: 655.2356599999998
- Similarity Product: 651.4452074156354

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test