PATENT CLAIM ANALYSIS

Application Number: 16107203
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["210", "634000"]

Abstract:
Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process.

Claim (Index 9):
The method of  claim 6 , wherein the denaturing buffer comprises one or more of the acid(s) selected from the group consisting of: acetic acid, trichloroacetic acid, and sulfosalicylic acid.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 96.0
- Lexical Diversity: 2.14286
- Patent Class: 210.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14598450', '14629315', '14598401', '14627559', '14645138']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8223760270494033
- 35 USC 102 Novelty (BERT): 0.6487947012626888
- Combined Prediction Score: 0.8050178944707318
- Mean Citation Score: 422.66383600000006
- Max Citation Score: 670.20746
- Similarity Product: 578.4928451756573

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test