PATENT CLAIM ANALYSIS

Application Number: 16446098
Application Type: Utility
Filing Date: 2019-06
Publication Date: 2019-10
Patent Classification: ["514", "262100"]

Abstract:
The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Claim (Index 44):
A compound of Formula VIIa: or a pharmaceutically acceptable salt thereof, wherein: G is NH, n is 0, and V is O; R 1  is C 1-3 alkyl; R 2  is halo, C 1-6 alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, C 1-6  haloalkoxy, phenyl, or 5-6 membered heteroaryl; wherein said phenyl and 5-6 membered heteroaryl are each optionally substituted by 1, 2, 3, or 4 substituents independently selected from halo, OH, CN, C 1-4 alkyl, C 1-4 alkoxy, and C 1-4 haloalkoxy; R 4  is H, halo, OH, CN, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy, or C 1-4 haloalkoxy; R 5  is halo, OH, CN, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy, C 1-4 haloalkoxy, or cyclopropyl; R 6  is H, halo, OH, CN, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy, or C 1-4 haloalkoxy; R 8  is H, halo, \u2014OH, \u2014CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, Cy 2 , \u2014(C 1-3 alkylene)\u2014Cy 2 , OR a2 , SR a2 , C(\u2550O)R b2 , C(\u2550O)NR c2 R d2 , C(\u2550O)OR a2 , OC(\u2550O)R b2 , OC(\u2550O)NR c2 R d2 , NR c2 R d2 , NR c2 C(\u2550O)R b2 , NR c2 C(\u2550O)OR b2 , NR c2 C(\u2550O) NR c2 R d2 ,C(\u2550NR e )R b2 , C(\u2550NR e )NR c2 R d2 , NR c2 C(\u2550NR e )NR c2 R d2 , NR c2 S(\u2550O)R b2 , NR c2 S(\u2550O) 2 NR c2 R d2 , S(\u2550O)R b2 , S(\u2550O)R b2 , or S(\u2550O) 2 NR c2 R d2 ; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl are each optionally substituted by 1, 2, 3, or 4 independently selected R 11  groups; R 10  is H or C 1-4 alkyl; each R c  is independently selected from H, CN, OH, C 1-4 alkyl, and C 1-4  alkoxy; each Cy 2  is independently selected from C 3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, or 9-10-membered bicyclic heteroaryl, each of which is optionally substituted with 1, 2, 3, or 4 independently selected R 11  groups; each R a2 , R b2 , R c2 , and R d2  is independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl; wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl are each optionally substituted with 1, 2, or 3 independently selected R 11  groups; or R c2  and R d2  together with the N atom to which they are attached form a 4-, 5-, 6-, or 7 membered heterocycloalkyl group, which is optionally substituted with \u2014OH or C 1-3 alkyl; and each R 11  is independently selected from OH, NO 2 , CN, halo, C 1-3 alkyl, C 2-3  alkenyl, C 2-3 alkynyl, C 1-3  haloalkyl, cyano-C 1-3 alkyl, HO\u2014C 1-3 alkyl, C 1-3  alkoxy-C 1-3 alkyl, C 3-7  cycloalkyl, C 1-3  alkoxy, C 1-3  haloalkoxy, amino, C 1-3 alkylamino, di(C 1-3 alkyl)amino, thio, C 1-3 alkylthio, C 1-3 alkylsulfinyl, C 1-3 alkylsulfonyl, carbamyl, C 1-3 alkylcarbamyl, di(C 1-3 alkyl)carbamyl, carboxy, C 1-3 alkylcarbonyl, C 1-4 alkoxycarbonyl, C 1-3 alkylcarbonylamino, C 1-3 alkylsulfonylamino, aminosulfonyl, C 1-3 alkylaminosulfonyl, di(C 1-3 alkyl)aminosulfonyl, aminosulfonylamino, C 1-3 alkylaminosulfonylamino, di(C 1-3 alkyl)aminosulfonylamino, aminocarbonylamino, C 1-3 alkylaminocarbonylamino, and di(C 1-3 alkyl)aminocarbonylamino.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 100.0
- Lexical Diversity: 1.41463
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14872881', '15673529', '16112160', '14872918', '13601349']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8277067068708424
- 35 USC 102 Novelty (BERT): 0.6517721550376587
- Combined Prediction Score: 0.810113251687524
- Mean Citation Score: 622.894354
- Max Citation Score: 758.6226
- Similarity Product: 562.6093792588234

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test