PATENT CLAIM ANALYSIS

Application Number: 16068670
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["435", "006130"]

Abstract:
Practical assays to identify compounds that overcome the resistance of  M. tuberculosis  to bedaquiline are based on transcription factors Rv0324 and Rv0880 shown to mediate this resistance.

Claim (Index 5):
A method to identify a drug useful in combination with bedaquiline (BDQ) to treat tuberculosis, which method comprises:\n (a) determining the transcriptome of an  M. tuberculosis  strain in a test sample that has been treated with a candidate drug; (b) determining the transcriptome of an  M. tuberculosis  strain in a control sample comprising a mutant of  M. tuberculosis  that is constitutively tolerant to BDQ; and (c) comparing said transcriptome of the test sample to that of the control sample; whereby a candidate drug that generates a transcriptome in the test sample similar to of that the control sample is identified as a drug useful in combination with BDQ.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 95.0
- Lexical Diversity: 1.12
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['09949041', '10481563', '13000788', '15381901', '14527281']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.515895656287428
- 35 USC 102 Novelty (BERT): 0.483456064022567
- Combined Prediction Score: 0.5126516970609418
- Mean Citation Score: 152.33914
- Max Citation Score: 159.17937
- Similarity Product: 109.84730405361772

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test