PATENT CLAIM ANALYSIS

Application Number: 16224140
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-08
Patent Classification: ["540", "456000"]

Abstract:
The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.

Claim (Index 33):
A method for obtaining a crystalline 40-O-(2-ethoxyethyl) rapamycin, the method comprising:\n a) forming a mixture consisting essentially of crude 40-O-(2-ethoxyethyl) rapamycin and a non-polar organic solvent under conditions sufficient to dissolve the 40-O-(2-ethoxyethyl) rapamycin, wherein the crude 40-O-(2-ethoxyethyl) rapamycin contains at least about 90% of 40-O-(2-ethoxyethyl) rapamycin by weight, wherein the dielectric constant of the non-polar organic solvent is less than about 5, and wherein forming the mixture comprises heating the mixture; b) solidifying at least a portion of the 40-O-(2-ethoxyethyl) rapamycin in a crystalline form, wherein the solidifying comprises cooling the mixture; and c) separating at least a portion of the solidified 40-O-(2-ethoxyethyl) rapamycin from the solvent in the mixture, wherein the solidified 40-O-(2-ethoxyethyl) rapamycin it at least about 95% pure; thereby obtaining the crystalline 40-O-(2-ethoxyethyl) rapamycin.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 98.0
- Lexical Diversity: 1.18182
- Patent Class: 540.0
- Transitional Phrase Type: half
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14853711', '15422593', '14804714', '16197037', '13497416']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7064175941506143
- 35 USC 102 Novelty (BERT): 0.545508722324268
- Combined Prediction Score: 0.6903267069679797
- Mean Citation Score: 263.926648
- Max Citation Score: 383.7347
- Similarity Product: 245.5461503250837

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test