PATENT CLAIM ANALYSIS

Application Number: 16288650
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["424", "001890"]

Abstract:
The present invention provides a pharmaceutical composition comprising [ 18 F]FACBC having certain advantages over known compositions comprising [ 18 F]FACBC. Also provided by the present invention is a method to obtain the composition of the invention.

Claim (Index 34):
A method of preparation of a PET tracer composition comprising (a) reacting in a reaction vessel a source of  18 F-fluoride with a precursor compound of Formula I: wherein:\n LG is a leaving group; \n PG 1  is a carboxy protecting group; \n and, PG 2  is an amine protecting group; \n to obtain a reaction mixture comprising a compound of Formula II: wherein PG 1  and PG 2  are as defined for Formula I;\n (b) carrying out removal of PG 1  to obtain a reaction mixture comprising a compound of Formula III: \n wherein PG 1  is as defined for Formula I;\n (c) carrying out removal of PG 2  to obtain a reaction mixture comprising  18 F-FACBC; and \n (d) purifying said reaction mixture comprising  18 F-FACBC by passing it through a hydrophilic lipophilic balanced (HLB) solid phase, wherein said purifying does not comprise passing the reaction mixture comprising  18 F-FACBC through an alumina solid phase.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 99.0
- Lexical Diversity: 1.48276
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14780900', '14420493', '15318122', '11425078', '15526245']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7233188530351657
- 35 USC 102 Novelty (BERT): 0.4994639937644841
- Combined Prediction Score: 0.7009333671080976
- Mean Citation Score: 213.502784
- Max Citation Score: 274.436
- Similarity Product: 231.89981825280185

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test