PATENT CLAIM ANALYSIS

Application Number: 15934536
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["530", "334000"]

Abstract:
This application pertains to orthogonally protected esters of peptide nucleic acid (PNA) monomers, which ester groups can be removed under conditions that permit typical backbone and side chain acid- and base-labile protecting groups to remain substantially intact thereby permitting the high yield of PNA monomer carboxylic acids that are suitable for use in PNA oligomer synthesis. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethyl (TCE), 2,2,2-tribromoethyl (TBE), 2-bromoethyl (2-BE) and 2-iodoethyl groups (2-IE). This invention also pertains to novel methods for the synthesis of Backbone Ester compounds and related Backbone Ester Acid Salts.

Claim (Index 15):
The compound of  claim 1 ,\n wherein, R 2  is H or methyl, each of R 9  and R 10  is H, each R 11  is independently H or D; and (i) one of R 3 , R 4 , R 5  and R 6  is independently selected from the group consisting of: IIIa, IIIb, IIIc, IIId, IIIe, IIIf, IIIg, IIIh, IIIi, IIIj, IIIk, IIIm, IIIn, IIIo, IIIp, IIIq, IIIr, IIIs, IIIt, IIIu, IIIv, IIIw, IIIx, IIIy, IIIz, IIIaa and IIIab, wherein each of IIIi, IIIj, IIIk, IIIm, IIIn, IIIo, IIIp, IIIq, IIIr, IIIs, IIIt, IIIu, IIIv, IIIw, IIIx, IIIy and IIIz optionally comprises a protecting group; and (ii) the others of R 3 , R 4 , R 5  and R 6  are H, D or F; and wherein, R 16  is selected from methyl, and t-butyl; and n is 1, 2, 3 or 4.

Metadata:
- Claim Count in Document: 51.0
- Percentile: 90.0
- Lexical Diversity: 1.48684
- Patent Class: 530.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13937674', '11182936', '10819769', '12151585', '13411450']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7154419101626665
- 35 USC 102 Novelty (BERT): 0.5144077027507793
- Combined Prediction Score: 0.6953384894214778
- Mean Citation Score: 226.086488
- Max Citation Score: 299.57407
- Similarity Product: 206.08705771283508

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test