PATENT CLAIM ANALYSIS

Application Number: 16060406
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["424", "204100"]

Abstract:
A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.

Claim (Index 25):
The method according to  claim 22 , wherein the producer cell culture is selected from a mammalian cell culture, a bacterial cell culture, and an insect cell culture, wherein said producer cells comprise at least (i) nucleic acid sequence encoding an AAV1 capsid operably linked to sequences which direct expression of the AAV1 capsid in the producer cells; (ii) a nucleic acid sequence comprising AAV inverted terminal repeat sequences and genomic transgene sequences for packaging into the AAV 1 capsid; and (iii) functional AAV rep sequences operably linked to sequences which direct expression thereof in the producer cells.

Metadata:
- Claim Count in Document: 31.0
- Percentile: 94.0
- Lexical Diversity: 1.28846
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13328306', '15081001', '10016767', '10020482', '10166347']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7304563222362569
- 35 USC 102 Novelty (BERT): 0.5212710695498093
- Combined Prediction Score: 0.7095377969676121
- Mean Citation Score: 310.08436599999993
- Max Citation Score: 335.3712
- Similarity Product: 255.73504851064683

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test