PATENT CLAIM ANALYSIS

Application Number: 15977768
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["514", "019300"]

Abstract:
The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. Exemplary compounds of the description include macrocyclic peptidomimetics with high affinity and selectivity for polo-like kinases, which may provide the basis for a new genre of anticancer therapeutics. Other exemplary compounds of the description include bi-valent compounds with that bind to polo-like kinases through both kinase domain and polo-box domain simultaneously by incorporating additional moieties that target Plk1 kinase domain, which significantly enhances affinitity relative and may provide the basis for a new genre of anticancer therapeutics. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

Claim (Index 6):
The compound of  claim 5 , wherein:\n R 2  is Et, Pr, i-Pr, Bu, each o is independently 1-3; each X is independently H, Me, Et, CF 3 , F, Cl, Br, OMe, or N(Me) 2 ; Y is CH 2 , NH, or O; and R 4  is \u2014(CH 2 ) 8 -Ph.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 2.025
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14111540', '14776512', '13320726', '13365707', '14710962']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7634518361063085
- 35 USC 102 Novelty (BERT): 0.5626820353581806
- Combined Prediction Score: 0.7433748560314958
- Mean Citation Score: 340.783414
- Max Citation Score: 432.70923
- Similarity Product: 331.0503579754257

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test