PATENT CLAIM ANALYSIS

Application Number: 15956133
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-04
Patent Classification: ["514", "017700"]

Abstract:
Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

Claim (Index 50):
The method of  claim 1 , wherein the necrosis inhibitor is a compound of Formula II: or a pharmaceutically acceptable salt, an ester, or a prodrug thereof, wherein: X is \u2014CH 2 \u2014, \u2014C(H)(R 14 )\u2014, \u2014C(\u2550S)\u2014, \u2014C(\u2550NH)\u2014, or \u2014C(O)\u2014; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10  each represent independently hydrogen, acyl, acetyl, alkyl, halogen, amino, C 1 -C 6 alkoxyl, nitro, \u2014C(O)R 12 , \u2014C(S)R 12 , \u2014C(O)OR 12 , \u2014C(O)NR 12 R 13 , \u2014C(S)NR 12 R 13 , or \u2014S(O 2 )R 12 ;\n R 11  is hydrogen, acyl, acetyl, alkyl, or acylamino; \n R 12  and R 13  each represent independently hydrogen, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteroaralkyl; \n R 14  is acyl, acetyl, alkyl, halogen, amino, acylamino, nitro, \u2014SR 11 , \u2014N(R 11 ) 2 , or \u2014OR 11 ; \n the bond indicated by (a) can be a single bond or a double bond; and \n the bond indicated by (b) can be a single bond or a double bond.

Metadata:
- Claim Count in Document: 73.0
- Percentile: 91.0
- Lexical Diversity: 1.66102
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15093480', '15288214', '14934810', '12086792', '15100967']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7793084599038012
- 35 USC 102 Novelty (BERT): 0.7418993699116065
- Combined Prediction Score: 0.7755675509045816
- Mean Citation Score: 535.4984059999998
- Max Citation Score: 823.15753
- Similarity Product: 811.420437008731

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test