PATENT CLAIM ANALYSIS

Application Number: 15743546
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["546", "153000"]

Abstract:
Compounds that inhibit Myeloid Cell Leukemia-1 (Mcl-1) oncoprotein, and methods of using the same, are provided for treating disease.

Claim (Index 2):
The compound of  claim 1 , wherein the compound is selected from the group consisting of 4-(N-(4-(4-chloro-3,5-dimethyl phenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid,\n 4-(N-(4-(4-chloro-3,5-dimethylphenoxy)phenyl)-N-isobutylsulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(4-(4-chloro-3,5-dimethylphenoxy)phenyl)-N-cyclopentylsulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-benzyl-N-(4-(4-chloro-3,5-dimethylphenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-benzylsulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(4-chlorophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(3-chlorobenzyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-(trifluoromethyl)phenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(2-chlorobenzyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(p-tolyl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(4-isopropylphenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(3-cyanophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-([1,1\u2032-biphenyl]-2-yl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-([1,1\u2032-biphenyl]-4-yl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-([1,1\u2032-biphenyl]-3-yl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-((4-phenylpiperazin-1-yl)sulfonyl)-2-naphthoic acid, 1-hydroxy-4-(N-(naphthalen-1-yl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(naphthalen-2-yl)sulfamoyl)-2-naphthoic acid, 4-(N-(4-cyanophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-methoxyphenyl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(2-(trifluoromethyl)phenyl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(4-nitrophenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(2-bromophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(3-bromophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(cyclohexylmethyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, methyl 4-(N-(4-bromophenyl)-N-isobutylsulfamoyl)-1-methoxy-2-naphthoate, methyl 4-(N-(4-bromophenyl)-N-isobutylsulfamoyl)-1-hydroxy-2-naphthoate, 4-(N-(4-bromophenyl)-N-isobutylsulfamoyl)-1-methoxy-2-naphthoic acid, 1-hydroxy-4-(piperidin-1-ylsulfonyl)-2-naphthoic acid, 4-(N-(4-chlorobenzyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(2,4-dibromophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-isopropoxyphenyl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(4-(naphthalen-1-yloxy)phenyl)sulfamoyl)-2-naphthoic acid, 4-(N,N-dimethylsulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-phenoxyphenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(4-(3-bromophenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-(p-tolyloxy)phenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(4-(2,4-dichlorophenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-((4-benzylpiperazin-1-yl)sulfonyl)-1-hydroxy-2-naphthoic acid, 4-(N-(4-(4-chlorophenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(4-(3,5-dimethylphenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-phenylsulfamoyl)-2-naphthoic acid, 4-(N-(4-bromophenyl)-N-isobutyl sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-sulfamoyl-2-naphthoic acid, 1-hydroxy-4-(N-isobutyl-N-(4-isopropoxyphenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(4-bromophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, methyl 1-hydroxy-4-(N-isobutyl-N-(4-isopropoxyphenyl)sulfamoyl)-2-naphthoate, acetoxymethyl 1-hydroxy-4-(N-isobutyl-N-(4-isopropoxyphenyl)sulfamoyl)-2-naphthoate, 1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-((4-bromophenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-((4-phenoxyphenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-(naphthalen-2-ylsulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-((4-(3,5-dimethylphenoxy)phenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-((4-(p-tolylthio)phenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-(isobutoxycarbonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-(4-phenoxybenzyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, phenyl 1-((4-(4-chloro-3,5-dimethylphenoxy)phenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylate, 1-((4-(4-chloro-3,5-dimethylphenoxy)phenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxamide, methyl 1-((4-(4-chloro-3,5-dimethylphenoxy)phenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylate, acetoxymethyl 1-((4-(4-chloro-3,5-dimethylphenoxy)phenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylate, 1-((4-fluorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-([1,1\u2032-biphenyl]-4-ylsulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-((4-(p-tolyloxy)phenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-(quinolin-8-ylsulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, 1-((4-(4-chloro-3,5-dimethylphenoxy)phenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, (\u00b1)-1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinoline-3-carboxylic acid, (\u00b1)-1-((4-bromophenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-3-carboxylic acid, (\u00b1)-14(4-fluorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-3-carboxylic acid, (\u00b1)-1-([1,1\u2032-biphenyl]-4-ylsulfonyl)-1,2,3,4-tetrahydroquinoline-3-carboxylic acid, (\u00b1)-1-(naphthalen-2-ylsulfonyl)-1,2,3,4-tetrahydroquinoline-3-carboxylic acid, (\u00b1)-1-((4-(4-chloro-3,5-dimethylphenoxy)phenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-3-carboxylic acid, (\u00b1)-1-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-1,2,3,4-tetrahydroquinoline-3-carboxylic acid, 4-(N-isobutylphenylsulfonamido)benzoic acid, 4-(N-isobutyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)benzoic acid, 4-(N-isobutylnaphthalene-2-sulfonamido)benzoic acid, 2-hydroxy-4-(N-isobutylphenylsulfonamido)benzoic acid, 2-hydroxy-4-(N-isobutyl-4-methylphenylsulfonamido)benzoic acid, 4-(4-bromo-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 2-hydroxy-4-(N-isobutyl-4-(p-tolyloxy)phenylsulfonamido)benzoic acid, 4-(4-(3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 4-(4-(2,4-dichlorophenoxy)-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 2-hydroxy-4-(4-phenoxyphenylsulfonamido)benzoic acid, 3-(N-isobutylphenylsulfonamido)benzoic acid, 3-(N-isobutyl-4-methylphenylsulfonamido)benzoic acid, 2-hydroxy-5-(N-isobutylnaphthalene-2-sulfonamido)benzoic acid, 5-(4-(4-chloro-3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, methyl 2-hydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzoate, 4-(N-benzyl-4-phenoxyphenylsulfonamido)-2-hydroxy-N-(phenylsulfonyl)benzamide, 4-(N-benzyl-4-phenoxyphenylsulfonamido)-2-hydroxy-N-(methylsulfonyl)benzamide, 4-(N-isobutyl-4-phenoxyphenylsulfonamido)-2-((4-(((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)carbamoyl)benzyl)oxy)benzoic acid, 4-(4-fluoro-N-isobutylphenylsulfonamido)benzoic acid, 4-(4-(4-chloro-3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)benzoic acid, 2-hydroxy-4-(N-isobutylnaphthalene-2-sulfonamido)benzoic acid, 2-hydroxy-4-(N-isobutyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)benzoic acid, 4-(N-cyclopentyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)-2-hydroxybenzoic acid, 4-(N-cyclopentylnaphthalene-2-sulfonamido)-2-hydroxybenzoic acid, 4-(4-(4-chloro-3,5-dimethylphenoxy)-N-cyclopentylphenylsulfonamido)-2-hydroxybenzoic acid, 3-(N-isobutylnaphthalene-2-sulfonamido)benzoic acid, 3-(N-isobutyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)benzoic acid, 3-(4-(4-chloro-3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)benzoic acid, phenyl 2-hydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzoate, acetoxymethyl 2-hydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzoate, N-(4-cyano-3-hydroxyphenyl)-N-isobutyl-4-phenoxybenzenesulfonamide, 4-(N-benzyl-4-phenoxyphenylsulfonamido)-2-hydroxy-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide, 4-(N-benzyl-4-(4-chloro-3,5-dimethylphenoxy)phenylsulfonamido)-2-hydroxy-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide, 3-(4-(4-chloro-3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 4-(4-fluoro-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 2-hydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzoic acid, 4-(N-benzyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)-2-hydroxybenzoic acid, 4-(N-benzylnaphthalene-2-sulfonamido)-2-hydroxybenzoic acid, 4-(N-benzyl-4-(4-chloro-3,5-dimethylphenoxy)phenylsulfonamido)-2-hydroxybenzoic acid, 3-(4-fluoro-N-isobutylphenylsulfonamido)benzoic acid, 2-hydroxy-5-(N-isobutylphenylsulfonamido)benzoic acid, 2-hydroxy-5-(N-isobutyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)benzoic acid, N-(4-(2H-tetrazol-5-yl)phenyl)-N-isobutyl-4-phenoxybenzenesulfonamide, N,2-dihydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzamide, N-isobutyl-N-(4-(3-oxo-2,3-dihydroisoxazol-5-yl)phenyl)-4-phenoxybenzenesulfonamide, 5-(N-benzyl-4-(4-chloro-3,5-dimethylphenoxy)phenylsulfonamido)-2-hydroxybenzoic acid, 5-(N-benzyl-4-(4-chloro-3,5-dimethylphenoxy)phenylsulfonamido)-2-hydroxy-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide, and the pharmaceutically acceptable salts, solvates, hydrates, cocrystals, or prodrugs thereof.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 86.0
- Lexical Diversity: 1.04348
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12104294', '12096393', '14763468', '13823810', '13526337']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7887747884230915
- 35 USC 102 Novelty (BERT): 0.5055101307911348
- Combined Prediction Score: 0.7604483226598958
- Mean Citation Score: 268.77087199999994
- Max Citation Score: 276.15472
- Similarity Product: 215.3002506047154

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test