PATENT CLAIM ANALYSIS

Application Number: 16035771
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["424", "452000"]

Abstract:
Embodiments of the disclosure relate generally to formulations, methods, kits, and dosage forms for improved stability of an active pharmaceutical ingredient, wherein the active ingredient comprises a compound of the formula: wherein X is N, Y is H or optionally substituted C 1 -C 6  alkyl; R 4  is morpholine optionally substituted with by C 1 -C 6  alkyl; R 7  is C 1 -C 6  alkyl optionally substituted by one or more F; R 8′  is halogen; and R 6  is wherein R 10  is H, C 1 -C 6  alkyl, halogen, CN or CF 3 ; R 12  is H or halogen; R 13  is H, halogen or C 1 -C 6  alkyl; and R 17  is H, C 1 -C 6  alkyl, (C 1 -C 6  alkyl)-NH 2 ; and, pharmaceutically acceptable salts and free bases thereof, wherein the active ingredient remains in substantially amorphous form after storage of the pharmaceutical formulation for a predetermined time and conditions. In one embodiment the formulations, methods, kits and dosage forms comprising the active pharmaceutical ingredient with improved stability can be used in the treatment of a condition characterized by the dysregulation of one of both of the RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways.

Claim (Index 7):
The formulation of  claim 1 , wherein the one or more stabilizing polymers comprises a polyvinylpyrrolidone polymer.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 95.0
- Lexical Diversity: 2.41053
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15581330', '15290788', '14783903', '16073355', '13957470']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7794441649604054
- 35 USC 102 Novelty (BERT): 0.5387721296124279
- Combined Prediction Score: 0.7553769614256076
- Mean Citation Score: 334.927828
- Max Citation Score: 392.866
- Similarity Product: 226.654232486248

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test