PATENT CLAIM ANALYSIS

Application Number: 15762849
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["546", "322000"]

Abstract:
Provided are an inositol nicotinate crystalline form A and a preparation method therefor. The X-ray powder diffraction analysis, obtained by using Cu-Kα ray measurement, of the inositol nicotinate crystalline form A has obvious characteristic diffraction peaks at least at 2θ values, expressed in degrees, of 7.05, 7.41, 9.74, 17.80, 19.86, 23.57, 25.48 and 26.20 with an error range of +/−0.2°. The preparation method is one of or a mixed crystallization method of two or more of an evaporation crystallization method, a cooling crystallization method or an anti-solvent crystallization method. The process thereof is simple and easy to operate, and has more selectivity; the inositol nicotinate crystalline form A can be prepared by various methods, and the prepared product has a good crystallization degree and high chemical stability; and the inositol nicotinate crystalline form A prepared by the present method does not have the problem that a residual solvent is out-of-limit.

Claim (Index 15):
The method of  claim 12 , wherein\n the evaporative crystallization method comprises the following steps: dissolving inositol nicotinate is dissolved in a mixed solvent of alkyl halide and alcohol, or a mixed solvent of alkyl halide with alcohol in water, and placing at room temperature or heating to volatilize or evaporate the alkyl halide in the system until solid crystals are precipitated, filtered, washed and dried; and/or the cooling crystallization method comprises the following steps: dissolving inositol nicotinate in a mixed solvent of alkyl halide and alcohol, or a mixed solvent of alkyl halide with alcohol in water, heating to dissolve, and then cooling until solid crystals are precipitated, then filtered, washed and dried; and/or the anti-solvent crystallization method comprises the following steps: dissolving inositol nicotinate in a mixed solvent of alkyl halide with alcohol, or a mixed solvent of alkyl halide with alcohol in water, adding alcohol solvent dropwise at room temperature until solid crystals are precipitated, then filtered, washed and dried; and/or the mixed crystallization method comprises the following steps: dissolving inositol nicotinate in a mixed solvent of alkyl halide and alcohol, or a mixed solvent of alkyl halide with alcohol in water, and evaporating alkyl halide by heating, meanwhile, adding alcohol solvent to the reaction liquid solid until crystals are precipitated, then filtered, washed and dried.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.89888
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14896748', '16087317', '15549918', '16300303', '10527193']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.780258542892904
- 35 USC 102 Novelty (BERT): 0.4898257907871389
- Combined Prediction Score: 0.7512152676823274
- Mean Citation Score: 207.13343
- Max Citation Score: 211.54416
- Similarity Product: 149.2586923056507

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test