PATENT CLAIM ANALYSIS

Application Number: 16336363
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "234200"]

Abstract:
The present invention relates to a class of cyano-substituted-heterocycles of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction. (I)

Claim (Index 10):
A compound, which is selected from:\n 3-(6-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)piperidine-1-carbonitrile; 2-(6-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)morpholine-4-carbonitrile; 3-(4-(3-cyanophenyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carbonitrile; 2-(4-phenyl-1H-benzo[d]imidazol-2-yl)morpholine-4-carbonitrile; 2-(4-(3-cyanophenyl)-1H-benzo[d]imidazol-2-yl)morpholine-4-carbonitrile; 2-(3-([1,1\u2032-biphenyl]-3-yl)-1H-1,2,4-triazol-5-yl)morpholine-4-carbonitrile; 3-(4-(2-phenoxyphenyl)oxazol-2-yl)piperidine-1-carbonitrile; 3-(4-([1,1\u2032-biphenyl]-3-yl)oxazol-2-yl)piperidine-1-carbonitrile; (R)-3-(5-([1,1\u2032-biphenyl]-3-yl)-1,3,4-oxadiazol-2-yl)-3-fluoropiperidine-1-carbonitrile; 3-(5-([1,1\u2032-biphenyl]-4-yl)-1,3,4-oxadiazol-2-yl)-3-fluoropiperidine-1-carbonitrile; (R)-4-(5-(1-cyano-3-fluoropiperidin-3-yl)-1,3,4-oxadiazol-2-yl)-[2,4\u2032-bipyridine]-2\u2032-carbonitrile; (R)-4-(5-(1-cyano-3-fluoropiperidin-3-yl)-1,3,4-oxadiazol-2-yl)picolinonitrile; (R)-2\u2032-(5-(1-cyano-3-fluoropiperidin-3-yl)-1,3,4-oxadiazol-2-yl)-[4,4\u2032-bipyridine]-2-carbonitrile; 3-(6-(1H-pyrazol-5-yl)-1H-benzo[d]imidazol-2-yl)-3-fluoropiperidine-1-carbonitrile; (R)-3-fluoro-3-(5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)piperidine-1-carbonitrile; (S)-3-(5-(3-cyanophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)-3-fluoropiperidine-1-carbonitrile; 3-(5-(1H-pyrazol-5-yl)-3H-imidazo[4,5-b]pyridin-2-yl)-3-fluoropiperidine-1-carbonitrile; (R)-4-(2-(1-cyano-3-fluoropiperidin-3-yl)-3H-imidazo[4,5-b]pyridin-6-yl)picolinonitrile; (R)-4-(2-(1-cyano-3-fluoropiperidin-3-yl)-1H-imidazo[4,5-b]pyridin-5-yl)picolinonitrile; 3-(6-(3-cyanophenyl)-1H-imidazo[4,5-b]pyridin-2-yl)-3-fluoropiperidine-1-carbonitrile; (R)-6-(2-(1-cyano-3-fluoropiperidin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)picolinonitrile; (R)-3-(5-(3-cyanophenyl)benzo[d]oxazol-2-yl)-3-fluoropiperidine-1-carbonitrile; (R)-6-(2-(1-cyano-3-fluoropiperidin-3-yl)benzo[d]oxazol-5-yl)pyrimidine-4-carbonitrile; (R)-2-(2-(1-cyano-3-fluoropiperidin-3-yl)benzo[d]oxazol-5-yl)pyrimidine-4-carbonitrile; (R)-4-(2-(1-cyano-3-fluoropiperidin-3-yl)benzo[d]oxazol-5-yl)picolinonitrile; (R)-2-(2-(1-cyano-3-fluoropiperidin-3-yl)benzo[d]oxazol-5-yl)isonicotinonitrile; (R)-4-(2-(1-cyano-3-fluoropiperidin-3-yl)benzo[d]oxazol-6-yl)picolinonitrile; 3-(6-(3-cyanophenyl)oxazolo[5,4-b]pyridin-2-yl)-3-fluoropiperidine-1-carbonitrile; 3-(6-(3-cyanophenyl)oxazolo[4,5-b]pyridin-2-yl)-3-fluoropiperidine-1-carbonitrile; (R)-4-(2-(1-cyano-3-fluoropiperidin-3-yl)oxazolo[5,4-b]pyridin-6-yl)picolinonitrile; and (R)-4-(2-(1-cyano-3-fluoropiperidin-3-yl)imidazo[1,2-a]pyridin-7-yl)picolinonitrile; a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 99.0
- Lexical Diversity: 1.32558
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16070936', '16080506', '15738900', '15894025', '16078518']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8443808568499985
- 35 USC 102 Novelty (BERT): 0.5581397407723202
- Combined Prediction Score: 0.8157567452422306
- Mean Citation Score: 433.761262
- Max Citation Score: 448.00748
- Similarity Product: 340.849967310338

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test