PATENT CLAIM ANALYSIS

Application Number: 15776698
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "685000"]

Abstract:
The invention relates to the use of a compound of Formula (I) as described herein and its effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.

Claim (Index 1):
A method for prevention and/or treatment of a fibrosis disease in a subject, comprising administering an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt, solvate or prodrug as an active ingredient to the subject, wherein R 1  is halogen, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, NH 2 , NO 2 , OH or CN; each R 2  is the same or different, representing H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, NH 2 , NO 2 , C 1-10 alkyloxy, C 1-10 alkylthio, C 1-10 alkylamino, C 1-10 alkyloxyC 1-10 alkyl, OH or CN, C 6-10 aryl or C 5-7 heterocyclic having 1 to 3 heteroatoms selected from the group consisting of N, O and S; R 3  is H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, NH 2 , NO 2 , OH or CN; R 4  is H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, NH 2 , NO 2 , OH or CN; R 5  is absent, OH, C 3-10 cycloalkyl, C 6-10 aryl, C 5-7 heterocyclic ring having 0 to 3 heteroatoms selected from O; N and S or C 10-12  fused heterocyclic ring having 0 to 3 heteroatoms selected from O; N and S, each of cycloalkyl, aryl, heterocyclic ring and fused heterocyclic ring is unsubstituted or substituted with one to three of OH; halogen; NH 2 ; NO 2 , CN, C 1-10 alkyl; C 2-10 alkenyl; C 2-10 alkynyl; C 1-10 alkyloxy; C 5-10 heteroaryl having 1 to 3 heteroatoms selected from the group consisting of N, O and S, unsubstituted or substituted with C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, OH, halogen, CN, NH 2  or NO 2 ; \u2014S(O) 2 -phenyl wherein the phenyl is unsubstituted or substituted with halogen, OH, CN, NH 2 , NO 2 , C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl or C 1-10 alkyloxy; \u2014C(O)NHOH; \u2014C(O)NH 2 ; \u2014C(O)-phenyl wherein phenyl is unsubstituted or substituted with 1-5 same or different substituents selected from the group consisting of OH, halogen, CN, NH 2 , NO 2 , C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl or C 1-10 alkyloxy; \u2014C(O)NR a R b ; NHS(O) 2 phenyl wherein phenyl is optionally substituted with OH, halogen, CN, NH 2 , NO 2 , C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl or C 1-10 alkyloxy; C 1-10 alkylene-heteroaryl; \u2014S(O) 2 -heteroaryl; \u2014S(O) 2 -heterocylic ring; \u2014S(O) 2 N(H)-heteroaryl; -alkylene-N(H)-heteroaryl; heterocylic ring unsubstituted or substituted with C 1-10 alkyl; and R a  and R b  are the same or different, independently representing H; OH; alkyl; alkenyl; alkynyl; alkyloxy; cycloalkyl; heterocylyl; alkyleneamino; alkylene-N-(alkyl) 2 ; aryl unsubstituted or substituted with OH, halogen, CN, NH 2 , NO 2 , alkyl, alkenyl, alkynyl, alkyloxy or heteroaryl; heteroaryl unsubstituted or substituted with OH, halogen, CN, NH 2 , NO 2 , alkyl, alkenyl, alkynyl or alkyloxy; alkylene-heteroaryl; or alkylene-heterocylyl unsubstituted or substituted with alkyl; X is \u2014C(O), \u2014S(O) 2  or \u2014NH\u2014C(O)\u2014; Y is \u2014C\u2014 or \u2014N\u2014; m is an integer of 0-3; and\n n is an integer of 0-7.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 93.0
- Lexical Diversity: 1.25
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15746964', '10399231', '15300762', '16308041', '14769421']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7634114739939133
- 35 USC 102 Novelty (BERT): 0.5384259950159607
- Combined Prediction Score: 0.740912926096118
- Mean Citation Score: 288.404012
- Max Citation Score: 385.9365
- Similarity Product: 268.00923976314067

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test