PATENT CLAIM ANALYSIS

Application Number: 15966103
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["424", "093710"]

Abstract:
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.

Claim (Index 66):
The isolated modified primary human T cells of  claim 62 , which elicits no or a reduced GVHD response in a histoincompatible human recipient as compared to the GVHD response elicited by primary human T cells isolated from the same human donor that are only modified by the introduction of said nucleic acid which encodes for and results in the expression at least one exogenous non-TCR that comprises a pathogen-associated receptor ligand binding domain.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 91.0
- Lexical Diversity: 2.4898
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13459664', '14934256', '13502978', '15003968', '15948303']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7460937478192864
- 35 USC 102 Novelty (BERT): 0.5981304089743642
- Combined Prediction Score: 0.7312974139347942
- Mean Citation Score: 519.2540019999999
- Max Citation Score: 542.2982
- Similarity Product: 431.2745378191352

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test