PATENT CLAIM ANALYSIS

Application Number: 16022031
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-02
Patent Classification: ["514", "234500"]

Abstract:
The present invention provides aza-heteroaryl derivatives of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A, W, R 4 , R 5 , and R 6  are defined herein, that inhibit the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Claim (Index 18):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein: A is O, S, or CH\u2550CH; R 1  and R 2  are each independently selected from H, OR a1 , NO 2 , CN, halo, C 1-6  alkyl, C 1-6  haloalkyl, and Cy 2 ; R 3  is H, methyl, or ethyl; or R 1  and R 2 , together with the carbon atoms to which they are attached, form a phenyl ring, which is optionally substituted by 1, 2, or 3 independently selected R 11  groups; R 4 , R 5 , and R 6  are each H; W is Br or Cy; Cy is 6-membered heteroaryl, which is optionally substituted by 1, 2, or 3 substituents independently selected from halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, Cy 1 , \u2014(C 1-4  alkylene)-Cy 1 , CN, NO 2 , OR a , SR a , C(O)R b , C(O)NR c R d , C(O)OR a , OC(O)R b , OC(O)NR c R d , NR c R d , NR c C(O)R b , NR c C(O)OR a , NR c C(O)NR c R d , C(\u2550NR e )R b , C(\u2550NR e )NR c R d , NR c C(\u2550NR e )NR c R d , NR c S(O)R b , NR c S(O) 2 R b , NR c S(O) 2 NR c R d , S(O)R b , S(O)NR c R d , S(O) 2 R b , and S(O) 2 NR c R d ; each Cy 2  is independently selected from phenyl, C 3-7  cycloalkyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl; each R 11  is independently selected from halo, C 1-6  alkyl, and C 1-6  haloalkyl; each R a1  is independently selected from H, C 1-6  alkyl, and C 14  haloalkyl; each R a , R c , and R d  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy 1 , and \u2014(C 1-4  alkylene)-Cy 1 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1, 2, 3, or 4 independently selected R g  groups; each R b  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy 1 , and \u2014(C 1-4  alkylene)-Cy 1 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1, 2, 3, or 4 independently selected R g  groups; or any R c  and R d  together with the N atom to which they are attached form a 4-6 membered heterocycloalkyl group or a 5-6 membered heteroaryl group, each optionally substituted with 1, 2, or 3 independently selected R g  groups; each R e  is independently selected from H and C 1-6  alkyl; each Cy 1  is independently selected from phenyl, 5-6 membered heteroaryl, C 3-7  cycloalkyl, and 4-6 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 independently selected R g  groups; and each R g  is independently selected from OH, NO 2 , CN, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, cyano-C 1-3  alkyl, HO\u2014C 1-3  alkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, amino, C 1-6  alkylamino, di(C 1-6  alkyl)amino, thio, C 1-6  alkylthio, C 1-6  alkylsulfinyl, C 1-6  alkylsulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, carboxy, C 1-6  alkylcarbonyl, C 1-6  alkoxycarbonyl, C 1-6  alkylcarbonylamino, C 1-6  alkylsulfonylamino, aminosulfonyl, C 1-6  alkylaminosulfonyl, di(C 1-6  alkyl)aminosulfonyl, aminosulfonylamino, C 1-6  alkylaminosulfonylamino, di(C 1-6  alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6  alkylaminocarbonylamino, and di(C 1-6  alkyl)aminocarbonylamino.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 94.0
- Lexical Diversity: 1.55769
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15019144', '13854789', '12972155', '15631417', '15065409']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7984049773115213
- 35 USC 102 Novelty (BERT): 0.5739295199583633
- Combined Prediction Score: 0.7759574315762054
- Mean Citation Score: 379.18514
- Max Citation Score: 453.30923
- Similarity Product: 443.000002491306

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test