PATENT CLAIM ANALYSIS

Application Number: 15967271
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["800", "019000"]

Abstract:
A transgenic non-human animal is provided. In certain embodiments, the animal comprises a genome comprising an immunoglobulin heavy chain locus comprising: a) a transcribed gene encoding a fusion protein comprising, from N-terminus to C-terminus: i. a scaffold comprising a first binding domain; and ii. a heavy chain constant region operably linked to the scaffold; wherein the scaffold is capable of specifically binding to a target in the absence of additional polypeptides; and b) a plurality of pseudogenes that are operably linked to the transcribed gene and that donate, by gene conversion, nucleotide sequence to the part of the transcribed gene that encodes the binding domain.

Claim (Index 23):
A transgenic chicken comprising a genome comprising an immunoglobulin heavy chain locus comprising:\n a) a transcribed gene encoding a fusion protein comprising, from N-terminus to C-terminus: a binding domain from a heavy chain-only antibody and, operably linked to said binding domain, at least part of a heavy chain constant region that is native to said transgenic chicken; and b) a plurality of pseudogenes that are operably linked to said transcribed gene and that donate, by gene conversion, nucleotide sequence to the part of said transcribed gene that encodes said binding domain, wherein the pseudogenes are upstream or downstream of the transcribed gene and contain a nucleotide sequence that is at least 80% identical to at least part of the transcribed gene; wherein the transgenic chicken produces a diversified population of heavy chain-only antibodies.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 91.0
- Lexical Diversity: 1.83077
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14241806', '15177280', '15188724', '12854722', '14057820']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5914756269751654
- 35 USC 102 Novelty (BERT): 0.5339300076242581
- Combined Prediction Score: 0.5857210650400747
- Mean Citation Score: 331.05187400000005
- Max Citation Score: 382.58405
- Similarity Product: 329.9091277258873

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test