PATENT CLAIM ANALYSIS

Application Number: 15768396
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["424", "009600"]

Abstract:
The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

Claim (Index 56):
The complex of  claim 54 , wherein the fluorescent molecule is selected from the group consisting of:\n (i) a compound of Formula V: wherein Y is O, S or NR 53 ; Z is O or NR 53 ; R 51  is absent, alkoxy, optionally substituted amino, thiol, optionally substituted alkylthio, -linker-(anti-cancer agent), -linker-carbohydrate or -linker-lipid; R 52  is H, alkyl, cyclyl, heterocyclyl, aryl, heteroaryl, or -linker-lipid; and each R 53  is same or different and selected independently from the group consisting of alkyl, cyclyl, heterocyclyl, aryl, heteroaryl, optionally substituted PEG, -linker-carbohydrate, -linker-(anti-cancer agent), -linker-NH(CH 2 CO 2 H) 2 , -linker-CO 2 H, \u2003or -linker-lipid, each of which can be optionally substituted, optionally provided that at least one of R 51  and R 52  is optionally substituted PEG, -linker-carbohydrate, -linker-(anti-cancer agent), -linker-NH(CH 2 CO 2 H) 2 , -linker-CO 2 H, \u2003or -linker-lipid; (ii) a compound of Formula I: wherein R 11  is hydrogen, alkoxy, optionally substituted alkylamino, optionally substituted alkylthio, -linker-(anti-cancer agent), -linker-carbohydrate, or -linker -lipid; (iii) a compound of Formula II: wherein R 21  is Hydrogen, alkyl, cyclyl, heterocyclyl, aryl, heteroaryl, optionally substituted PEG, -linker-carbohydrate, -linker-(anti-cancer agent), -linker-NH(CH 2 CO 2 ) 2 , -linker-CO 2 , \u2003or -linker-lipid, each of which can be optionally substituted; (iv) a compound of Formula III: wherein R 31  and R 32  are same or different and selected independently from the group consisting of hydrogen, alkyl, cyclyl, heterocyclyl, aryl, heteroaryl, or -linker-lipid, each of which can be optionally substituted; (v) a compound a Formula IV: wherein X is O or NR 43 ; R 41  is absent, hydroxyl, alkoxy, -linker-lipid or polyethylene glycol; R 42  is H, alkyl, cyclyl, heterocyclyl, aryl or heteroaryl; and R 43  is H, alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, each of which can be optionally substituted; (i) a compound of Formula V\u2032: wherein Y, Z, R 51  and R 52  are as defined in compound V above; (ii) a compound of Formula I\u2032: wherein R 11  is hydrogen, alkoxy, alkylamino, alkylthio, -linker-carbohydrate, or -linker-lipid; (iii) a compound of Formula II\u2032: wherein R 21  is H, optionally substituted alkyl, optionally substituted PEG, -linker-carbohydrate, -linker-(anti-cancer agent), -linker-NH(CH 2 CO 2 H) 2 , -linker-CO 2 H, \u2003or -linker-lipid; (iv) a compound of Formula III\u2032: wherein R 31  and R 32  are same or different and independently H, optionally substituted alkyl, or -linker-lipid; (v) a compound of Formula IV\u2032: wherein X, R 41  and R 42  are as defined in compound of formula IV above; (vi) a compound of Formula I\u2033: wherein R 11  is hydrogen, alkoxy, alkylamino, alkylthio, -linker-(anti-cancer agent), -linker-carbohydrate, or -linker-lipid; (vii) a compound of Formula II\u2033: wherein R 21  is a optionally substituted PEG, -linker-carbohydrate, -linker-(anti-cancer agent), -linker-NH(CH 2 CO 2 ) 2 , -linker-CO 2 , or linker-lipid;\n (viii) a compound of Formula III\u2033: \n wherein at least one of R 31  and R 32  is a -linker-lipid; (ix) a compound of Formula V\u2033: wherein: each X is same or different and selected independently from the group consisting of O, N, S, NH and NR each R\u2032 is same or different and selected independently from the group consisting of H, alkyl, cyclyl, heterocyclyl, aryl and heteroaryl, each of which can be optionally substituted; and R is alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, each of which can be optionally substituted; (x) a compound of Formula V\u2033-B: wherein: Z is alkoxy, alkylamino, alkylthio or -E-linker-carbohydrate; E is O, NH or S; each X is same or different and selected independently from the group consisting of O, N, S, NH and NR each R\u2032 is same or different and selected independently from the group consisting of H, alkyl, cyclyl, heterocyclyl, aryl and heteroaryl, each of which can be optionally substituted; and R is alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, each of which can be optionally substituted. (xi) a compound of Formula V\u2032\u2033: wherein: E is NH or S; X is O or NR; and R is H, alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, each of which can be optionally substituted; or (xii) a compound Formula V\u2032\u2033-B: wherein: E is NH or S; R\u2032 is optionally substituted PEG, -linker-carbohydrate, -linker-(anti-cancer agent), -linker-NH(CH 2 CO 2 ) 2 , -linker-CO 2 , X is O or NR; R is H, alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, each of which can be optionally substituted; and wherein the fluorescent molecule is conjugated with a lipid.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 91.0
- Lexical Diversity: 1.90244
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13537814', '14898355', '12871226', '13504822', '14643107']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7631383236426513
- 35 USC 102 Novelty (BERT): 0.5237201636103398
- Combined Prediction Score: 0.7391965076394201
- Mean Citation Score: 299.569812
- Max Citation Score: 316.01404
- Similarity Product: 223.96342629013063

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test