PATENT CLAIM ANALYSIS

Application Number: 15910677
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "064000"]

Abstract:
A method is disclosed for altering the redox equilibrium of a transmembrane receptor-like protein tyrosine phosphatase (RPTP), particularly a type IIa RPTP, by chemically modulating the activity through contact of such an enzyme with a diaryl boron compound that preferentially reacts with an RPTP in an oxidized state (CyS-OH). This redox modulation is most readily observed and put to use by assaying the inhibition of the phosphatase activity of the RPTP. Such an assay can be carried out on an enzyme in vitro or by contacting the enzyme in a living organism (in vivo). A useful diaryl boron compound corresponds in structure to Formula I in which Ar-1, Ar-2, R 1 , R 2 , R 3  and R 4  are defined within. A pharmaceutical composition containing a useful diaryl boron compound is also disclosed, as are particularly preferred diaryl boron compounds.

Claim (Index 33):
The method according to  claim 32 , wherein each of R 10 , R 11 , R 12  and R 13  is the same.

Metadata:
- Claim Count in Document: 116.0
- Percentile: 90.0
- Lexical Diversity: 1.73626
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11280724', '10777186', '11219402', '12043872', '11508605']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7145432055697731
- 35 USC 102 Novelty (BERT): 0.5217722858949019
- Combined Prediction Score: 0.695266113602286
- Mean Citation Score: 225.159968
- Max Citation Score: 234.57724
- Similarity Product: 130.5609739353442

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test