PATENT CLAIM ANALYSIS

Application Number: 15916752
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "212080"]

Abstract:
The present invention provides modulators of protein function, to restore protein homeostasis, including GSPT1 activity. The invention provides methods of modulating protein-mediated diseases, such as GSPT1-mediated diseases, disorders, conditions, or responses. Compositions are also provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions, such as GSPT1-mediated diseases, disorders, and conditions, including cancer and astrogliosis.

Claim (Index 1):
A compound of Formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: R 1 , R 2 , R 3 , and R 4 , are each independently selected from the group consisting of H, deuterium, halogen, cyano, nitro, \u2014NH 2 , \u2014NHR 7 , NR 7 R 7 , an optionally substituted C 1  to C 6  alkoxy, an optionally substituted C 1  to C 6  alkyl, \u2003wherein at least one of R 1 , R 2 , R 3 , and R 4  is R 5  is selected from the group consisting of H, deuterium, fluoro, and an optionally substituted C 1  to C 6  alkyl; R 6  is selected from the group consisting of H, deuterium, and an optionally substituted C 1  to C 6  alkyl; X is selected from the group consisting of CH 2  and C\u2550O; X 2  is selected from the group consisting of (CH 2 ) n , (CD 2 ) n , (CF 2 ) n , C\u2550O, NH, N-(an optionally substituted C 1  to C 6  alkyl), [(CH 2 ) p \u2014NH\u2014(CH 2 ) q ] t  and [(CH 2 ) p \u2014O\u2014(CH 2 ) q ] t ; X 3  is selected from the group consisting of NH, O, and S; wherein, when any of R 1 , R 2 , R 3 , or R 4  is \u2003X 2  is selected from the group consisting of (CH 2 ) n , (CD 2 ) n , C\u2550O, [(CH 2 ) p \u2014NH\u2014(CH 2 ) q ] t , and [(CH 2 ) p \u2014O\u2014(CH 2 ) q ] t ; m is 1, 2, 3, 4, or 5; n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; p and q are independently 0, 1, 2, 3, 4, 5, or 6; t is 0, 1, 2, 3, or 4; and R 7  is selected from the group consisting of an optionally substituted C 3  to C 10  cycloalkyl, an optionally substituted C 6  to C 10  aryl, an optionally substituted 5 to 10-membered heteroaryl, an optionally substituted 3 to 10-membered heterocyclyl, and an optionally substituted C 1  to C 10  alkyl.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 2.0
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15847628', '15892267', '15599401', '15597671', '15801124']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8296921977159327
- 35 USC 102 Novelty (BERT): 0.5718940501372942
- Combined Prediction Score: 0.8039123829580689
- Mean Citation Score: 443.00221
- Max Citation Score: 471.74475
- Similarity Product: 371.8537126908749

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test