PATENT CLAIM ANALYSIS

Application Number: 16153180
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["544", "106000"]

Abstract:
The present invention provides compounds having a CB 1  receptor-binding moiety and a directing moiety. In related aspects, the invention provides pharmaceutical compositions containing compounds of the invention, methods for inhibiting a pathway modulated in part by the CB 1  receptor activity, and methods for treating a condition or disorder mediated in part by CB 1  receptor activity. In certain embodiments, the compounds are compounds of Formula I. Methods of preparing compounds of Formula I are also described. In another aspect, the invention provides methods of identifying a selective agonist of the beta-arrestin pathway over the G-protein pathway.

Claim (Index 1):
A compound having the Formula I: or a pharmaceutically acceptable salt thereof,\n wherein \n R 1  is selected from the group consisting of halo, cyano, nitro, and acetyl; \n R 2  is C 1-12  alkyl, \n R 3  is selected from the group consisting of H, C 3 -C 12  alkyl, C 3 -C 8  cycloalkyl, 4- to 8-membered heterocyclyl, C 6 -C 10  aryl, and 5- to 10-membered heteroaryl; \n W is selected from the group consisting of N and CR 1a , wherein R 1a  is selected from the group consisting of H and R 1 ; \n X is selected from the group consisting of O, C\u2550O, and NR 4 , wherein R 4  is selected from the group consisting of H and C 1-6  alkyl; \n Y 1 , Y 2 , and Y 3  are independently selected from the group consisting of N and CH; \n Z is selected from the group consisting of O, CH 2 , and NR 4 , wherein R 4  is selected from the group consisting of H and C 1-6  alkyl; \n subscript t is 0 when W is CR 1a  and R 1a  is R 1 ; \n subscript t is 1 when W is N or when W is CR 1a  and R 1a  is H; and \n L is selected from the group consisting of \n wherein R 5  and R 6  are H, R 7  and R 8  are independently selected from the group consisting of H and OH, provided that at least one of at least one of R 7  and R 8  is H, or R 5  and R 7  are absent and R 6  and R 8  are taken together to form a 5- to 6-membered unsaturated carbocyclic or heterocyclic group, and R 9  and R 10  are independently selected from the group consisting of H and OH, provided that at least of R 9  and R 10  is H, and; provided that if R 2  is C 1-12  alkyl, R 5 , R 6 , R 7 , and R 8  are H, and Y 1 , Y 2 , and Y 3  are CH, then R 3  is selected from the group consisting of C 3 -C 12  alkyl, C 3 -C 8  cycloalkyl, 4- to 8-membered heterocyclyl, C 6 -C 10  aryl, and 5- to 10-membered heteroaryl.

Metadata:
- Claim Count in Document: 40.0
- Percentile: 97.0
- Lexical Diversity: 1.96364
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15383922', '14207841', '16050227', '13646143', '12732428']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8009519065269396
- 35 USC 102 Novelty (BERT): 0.5309062168448397
- Combined Prediction Score: 0.7739473375587296
- Mean Citation Score: 258.800412
- Max Citation Score: 373.49158
- Similarity Product: 312.0660626624752

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test