PATENT CLAIM ANALYSIS

Application Number: 15868603
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["424", "244100"]

Abstract:
The present invention is based, in part, on flagellin adjuvant used to enhance immune responses directed against  Streptococcus pneumoniae , in particular, to enhance immune responses to polypeptide antigens (e.g., PspA) and capsular polysaccharide from  S. pneumoniae . In representative embodiments, the invention provides a fusion protein comprising a flagellin adjuvant and one more polypeptide antigens from  S. pneumoniae . In other embodiments, the invention provides a conjugate comprising a flagellin adjuvant covalently linked to a capsular polysaccharide from one or more serotypes of  S. pneumoniae . Also provided are compositions comprising the fusion proteins and/or conjugates of the invention as well as immunogenic formulations comprising the inventive fusion proteins, conjugates and/or compositions. The invention also provides methods of producing an immune response against  S. pneumoniae  and methods of protecting a subject from  S. pneumoniae  infection by administering the fusion proteins, conjugates, compositions and/or immunogenic formulations of the invention to the subject.

Claim (Index 3):
The fusion protein of  claim 1 , wherein the PspA antigen is a PspA1 antigen.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 86.0
- Lexical Diversity: 2.26027
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12665247', '13088141', '14597488', '12570266', '12665350']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7200279036026257
- 35 USC 102 Novelty (BERT): 0.5285548435573106
- Combined Prediction Score: 0.7008805975980942
- Mean Citation Score: 329.12929
- Max Citation Score: 336.76407
- Similarity Product: 213.46733268151044

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test