PATENT CLAIM ANALYSIS

Application Number: 16212914
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["073", "864830"]

Abstract:
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

Claim (Index 22):
A liquid chromatography system comprising\n A) a high-pressure pump; B) a chromatography column; C) a sample injector configured to load a sample into a sample loop at an atmospheric pressure and then to increase a pressure in the sample loop to a pump pressure, the sample injector comprising:\n a) an injection valve configured to have a LOAD position, a PRESSURE COMPENSATION position, and an INJECT position, the injection valve comprising:\n i) a first sample loop port; \n ii) a second sample loop port; \n iii) a first high pressure port connected to the high-pressure pump; and \n iv) a second high pressure port connected to the chromatography column; \n \n b) a sample conveying device comprising:\n i) a pump volume and \n ii) a plunger configured to be moved in a sealed fashion in the pump volume; \n \n c) the sample loop comprising two ends, in which the first sample loop port is connected to one of the two ends of the sample loop and the second sample loop port is connected to the other one of the two ends of the sample loop, in which the sample conveying device is positioned so as to form a part of the sample loop; and \n d) a control unit configured to\n i) control a change-over process of the injection valve to one of the LOAD position, the PRESSURE COMPENSATION position, and the INJECT position; \n ii) calculate a distance for a movement of the movable element within the pump volume from a first position to a second position to increase the pressure in the sample loop from the atmospheric pressure to the pump pressure based on a compressibility of the sample in the sample conveying device and the sample loop, the pump pressure, and an elasticity of the sample loop; and \n iii) control the sample conveying device to move the plunger within the pump volume by the calculated distance from the first position to the second position in the PRESSURE COMPENSATION position to increase the pressure in the sample loop from the atmospheric pressure to the pump pressure.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 98.0
- Lexical Diversity: 2.47692
- Patent Class: 73.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15596738', '12863976', '15959848', '15190570', '15190529']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7165913328987223
- 35 USC 102 Novelty (BERT): 0.5751010334753426
- Combined Prediction Score: 0.7024423029563844
- Mean Citation Score: 383.3975400000001
- Max Citation Score: 471.06497
- Similarity Product: 404.8535232817018

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test