PATENT CLAIM ANALYSIS

Application Number: 15999268
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-08
Patent Classification: ["564", "157000"]

Abstract:
The present disclosure provides novel compounds capable of functioning as Myoctye Enhancer Factor 2 (MEF2) modulators, as well as compositions, pharmaceutical formulations, methods of synthesis and kits. Also provided are methods of treating a condition regulatable by MEF2 and/or MEF2 cofactors using the compounds, compositions, pharmaceutical formulations, and kits provided herein.

Claim (Index 1):
A compound comprising a structure of Structure I: including pharmaceutically acceptable solvates, pharmaceutically acceptable prodrugs, pharmaceutically acceptable salts and pharmaceutically acceptable stereoisomers thereof, wherein:\n Y is independently selected from the group consisting of 2-aminophenyl and hydroxyl; \n X is independently selected from the group consisting of \u2014NH\u2014, \u2014NH\u2014(O\u2550C)\u2014(C\u2550OPh)H\u2014, \u2014NHC(\u2550O)\u2014, \u2014C(\u2550O)NH\u2014, \u2014(CH 2 ) n \u2014NH\u2014, \u2014(CH 2 ) n \u2014NH\u2014(CH 2 ) n , and \u2014NH\u2014(CH 2 ) n \u2014, where n is 1, 2, or 3; \n R 1 -R 3  are each independently selected from the group consisting of hydrogen, cyclopropyloxy, halogen, ethoxy, methoxy, methyl-mercaptan, ethoxy, ethyl, cyano, isopropyloxy, cyclobutyloxy, cyclopentyloxy, 3-oxetanyloxy, morpholinyl, 4-morpholinyl, dimethylamino, butyl, pyrrolidinyl, ethylmethylamino, piperidinyl, piperazinyl, diethylamino, dimethylaminomethyl, 3-oxetanyl, 2,2-difluoroethoxy, 1,1-difluoroethyl, methylsulfide, trifluoromethylsulfide, 2,2,2-trifluoroethoxy, and trifluoroethoxy, wherein at least one or two of R 1 -R 3  are not hydrogen; and \n R 4 -R 6  are each independently selected from the group consisting of hydrogen and halogen.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 96.0
- Lexical Diversity: 1.4878
- Patent Class: 564.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13843612', '14899335', '12358348', '12463452', '15528195']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.678233973215499
- 35 USC 102 Novelty (BERT): 0.4809290821577652
- Combined Prediction Score: 0.6585034841097257
- Mean Citation Score: 146.43964599999995
- Max Citation Score: 171.33522
- Similarity Product: 142.26641985286116

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test