PATENT CLAIM ANALYSIS

Application Number: 15987365
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "256000"]

Abstract:
This invention provides for an improved method for differentially diagnosing ACTH-dependent Cushing's syndrome. Current practice for differentially diagnosing ectopic ACTH syndrome and Cushing's Disease measures relative ACTH concentrations from the inferior petrosal venous sinus compared to fluid obtained from a periphery venous sample. This is performed before and after administration of exogenous corticotropin releasing factor, or after administration of metyrapone. This invention uses glucocorticoid receptor antagonists to induce release of endogenous CRH which stimulates ACTH to increase in patients with ectopic ACTH syndrome but not in those with Cushing's Disease.

Claim (Index 15):
The method of  claim 14 , wherein the fused azadeclin is a compound having the following formula: wherein\n L 1  and L 2  are members independently selected from a bond and unsubstituted alkylene; \n R 1  is a member selected from unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted heterocycloalkyl, \u2014OR 1A , NR 1C R 1D , \u2014C(O)NR 1C R 1d , and \u2014C(O)OR 1A , wherein \n R 1A  is a member selected from hydrogen, unsubstituted alkyl and unsubstituted heteroalkyl, \n R 1C  and R 1D  are members independently selected from unsubstituted alkyl and unsubstituted heteroalkyl, \n wherein R 1C  and R 1D  are optionally joined to form an unsubstituted ring with the nitrogen to which they are attached, wherein said ring optionally comprises an additional ring nitrogen; \n R 2  has the formula: \n wherein R 2G  is a member selected from hydrogen, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, \u2014CN, and \u2014CF 3 ; J is phenyl; t is an integer from 0 to 5; X is \u2014S(O 2 )\u2014; and R 5  is phenyl optionally substituted with 1-5 R 5A  groups, wherein R 5A  is a member selected from hydrogen, halogen, \u2014OR 5A1 , S(O 2 )NR 5A2 R 5A3 , \u2014CN, and unsubstituted alkyl, wherein R 5A1  is a member selected from hydrogen and unsubstituted alkyl, and R 5A2  and R 5A3  are members independently selected from hydrogen and unsubstituted alkyl, or salts and isomers thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.48485
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15236015', '15796443', '15627414', '15697878', '15915477']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7985039321335166
- 35 USC 102 Novelty (BERT): 0.6967407880168516
- Combined Prediction Score: 0.7883276177218501
- Mean Citation Score: 512.1089400000002
- Max Citation Score: 713.4526
- Similarity Product: 698.825925611329

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test