PATENT CLAIM ANALYSIS

Application Number: 16171046
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-03
Patent Classification: ["540", "557000"]

Abstract:
Tricyclic and tetracyclic derivatives of benzodiazepine, pyridodiazepine, and pyrimidodiazepine fused with 1,4-dihydropyridine derivatives are disclosed. The present derivatives can be obtained from derivatives containing a dihydropyrldine ring reacting with compounds of the ortho-phenyldiamine, ortho-diaminopyridine, and ortho-diaminopyrimidine type, as well as some subsequent transformations and, tricyclic and tetracyclic derivatives can be obtained with a diazepine or diazepinone nucleus fused to a 1,4-dihydropyridine nucleus, having a substituted or unsubstituted ring of benzene, pyridine or pyrimidine. The present derivatives exhibit vascular and central nervous system therapeutic activity.

Claim (Index 18):
A pharmaceutical composition comprising a compound of Formula I wherein: R represents H, an alkyl, a cyclic alkyl, a vinyl, an aryl, phenyl, or heteroaryl; R 1  represents H, alkyl, alicyclics, \u2014OR\u2032, \u2014NHR\u2033, \u2014NHR\u2032\u2033, \u2014NH\u2014(CH 2 ) n \u2014NH(C=O)-R 3 , \u2014NH\u2014CH(R 4 )\u2014COOH, \u2014NH\u2014OH, \u2014NH\u2014NH 2 , \u2014NH\u2014NH\u2014(C=O)-NH 2 , \u2014NH\u2014NH\u2014(C=S)\u2014NH 2 , or \u2014NHR 5 ; R\u2032 represents H, Nat*, K*, straight or branched alkyl groups having 1 to 24 carbon atoms, or lipid chains derived from mono or polyunsaturated fatty acids having up to 24 carbon atoms, R\u2033 represents H, straight or branched alkyl groups having 1 to 24 carbon, or lipid chains derived from mono or polyunsaturated fatty acids having up to 24 carbon atoms; R\u2032\u2033 represents \u2014(CH 2 ) n \u2014NH 2 ; n=1-10 R 2  represents an alkyl or a cycloalkyl; A represents benzene; and R 3  represents an alkyl; R 4  represents amino acid remnants; R 5  represents a thiazole, 4-phenylthiazole, or phenyl; wherein: alkyl groups, unless specified otherwise, are straight or branched having up to 8 carbon atoms and may be unsubstituted or substituted with a halogen; alicyclics have 1 to 16 carbon atoms; vinyl groups may be unsubstituted or substituted with a halogen; phenyl groups may be unsubstituted or substituted with one or more of \u2014NO 2 , \u2014NH 2 , \u2014OH, F, Cl, Br, I, \u2014CN, \u2014OCH 3 , \u2014N(CH 3 ) 2 , \u2014CH 3 , \u2014OCOCH 3 , \u2014COOCH 3 , \u2014OCF 3 , \u2014SH,  13  NH(C=O)\u2014CH 3 , \u2014CHO, \u2014C=NH, \u2014C=NH\u2014NH 2 , or \u2014C=NH\u2014OH; and benzene may be unsubstituted or substituted with one or more of OH, COOH, CH 3 , NO 2 , NH 2 , CHO, or halogens.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 97.0
- Lexical Diversity: 1.69643
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14282111', '13500983', '13397195', '14512059', '12700131']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6477813611463793
- 35 USC 102 Novelty (BERT): 0.6030408226664998
- Combined Prediction Score: 0.6433073072983914
- Mean Citation Score: 339.291398
- Max Citation Score: 545.46277
- Similarity Product: 434.0693076369488

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test