PATENT CLAIM ANALYSIS

Application Number: 15902547
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "249000"]

Abstract:
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1  (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Claim (Index 1):
A compound having a structure represented by a formula: wherein L is selected from \u2014(C\u2550O)\u2014, \u2014(S\u2550O)\u2014 and \u2014(SO 2 )\u2014; wherein each of Z 1  and Z 2  are independently selected from Q 6  or CR 4 , provided that Z 1  and Z 2  are not simultaneously Q 6  or simultaneously CR 4 ; wherein Q 1  is selected from N and CR 1a ; wherein Q 2  is selected from N and CR 1b  wherein Q 3  is selected from N and CR 1c ; wherein Q 4  is selected from N and CR 1d ; and wherein 0, 1, or 2 of Q 1 , Q 2 , Q 3 , and Q 4  are N;\n wherein each of R 1a , R 1b , R 1c , and R 1d , when present, is independently selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkoxy, C1-C6 alkoxy-C1-C6 alkyl, C1-C6 alkylamino, C1-C6 haloalkyl-oxy-C1-C6 alkyl, C1-C6 polyhaloalkyl-oxy-C1-C6 alkyl, and C1-C6 dialkylamino; \n wherein Q 5  is selected from N and CR 2a ; wherein Q 6  is selected from N and CR 2b ; wherein Q 7  is selected from N and CR 2c ; wherein Q 8  is selected from N and CR 2d ; and wherein 0, 1, or 2 of Q 5 , Q 6 , Q 7 , and Q 8  are N;\n wherein each of R 2a , R 2b , R 2c , and R 2d , when present, is independently selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkoxy, C1-C6 alkoxy-C1-C6 alkyl, C1-C6 alkylamino, C1-C6 haloalkyl-oxy-C1-C6 alkyl, C1-C6 polyhaloalkyl-oxy-C1-C6 alkyl, and C1-C6 dialkylamino; \n wherein each of R 3a  and R 3b  is independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, and C1-C6 polyhaloalkyl; wherein R 4  is selected from Ar 1 , Ar 2 , -L 2 -Ar 1 , -L 2 -Ar 2 , and Cy 1 ;\n wherein L 2  is selected from \u2014CR 8a R 8b \u2014, \u2014O\u2014, \u2014NR 9 \u2014, \u2014S\u2014, \u2014(S\u2550O)\u2014, and \u2014(SO 2 )\u2014;\n wherein each of R 8a  and R 8b  is independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, and C1-C6 polyhaloalkyl; \n wherein R 9  is selected from hydrogen and C1-C6 alkyl; \n \n wherein Ar 1  is selected from phenyl, indenyl, and naphthalenyl; and substituted with 0-3 substituents selected from halogen, hydroxyl, cyano, \u2014NH 2 , C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkylamino, and C1-C6 dialkylamino; \n wherein Ar 2  is selected from benzodioxolyl, benzofuranyl, benzoimidazolyl, benzoisoxazolyl, benzooxadiazolyl, benzooxazolyl, benzothiazolyl, benzothiophenyl, dihydrobenzodioxinyl, dihydrobenzofuranyl, dihydroisobenzofuranyl, furanyl, furopyridinyl, imidazolyl, imidazopyrazinyl, imidazopyridinyl, indazolyl, indolinyl, indolyl, isoindolinyl, isoquinolinyl, naphthyridinyl, oxadiazolyl, oxazolyl, oxoindolinyl, 2\u2032-oxospiro[1,3]dioxolane-2,3\u2032-indolinyl, pyrazinyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrrolopyridinyl, pyrrolyl, quinazolinyl, quinolinyl, quinoxalinyl, tetrahydroquinolinyl, thiadiazolyl, thiazolyl, and triazolyl; and wherein Ar 2  is substituted with 0-3 substituents selected from halogen, hydroxyl, cyano, \u2014NH 2 , C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkylamino, and C1-C6 dialkylamino; and \n wherein Cy 1  is a C2-C5 heterocycloalkyl or C2-C5 heterocycloalkenyl, and wherein Cy 1  is substituted with 0-3 substituents selected from halogen, hydroxyl, cyano, \u2014NH 2 , C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkylamino, and C1-C6 dialkylamino, and wherein two of the substituents are optionally covalently bonded, and together with the intermediate atoms, comprise an optionally substituted 3- to 6-membered fused ring group; \n wherein each of R 7a  and R 7b  is independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, and C1-C6 polyhaloalkyl; or a pharmaceutically acceptable salt, solvate, or polymorph thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.56716
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14787722', '14354560', '14787717', '14913266', '13692969']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8479328287898905
- 35 USC 102 Novelty (BERT): 0.6145960470829738
- Combined Prediction Score: 0.8245991506191989
- Mean Citation Score: 595.6632320000001
- Max Citation Score: 602.8802
- Similarity Product: 472.09551046469215

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test