PATENT CLAIM ANALYSIS

Application Number: 16095374
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "480000"]

Abstract:
An object of the present invention is to provide a novel compound having a strong opening action with respect to KCNQ2-5 channels. A compound represented by the general formula (1) (wherein the definition of each group is as described in the specification) is provided. The compound represented by the general formula (1) has a strong opening action with respect to KCNQ2-5 channels, and therefore is useful as a prophylactic and/or therapeutic agent for a KCNQ2-5 channel-related disease (for example, dysuria, overactive bladder, or the like).

Claim (Index 1):
A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof: (wherein R 1  is (1) a hydrogen atom or (2) a C 1-4  alkyl group; R 2  is (1) a hydrogen atom or (2) a C 1-4  alkyl group which may be substituted with a halogen; R 3 , R 4 , R 5 , and R 6  are each independently (1) a hydrogen atom, (2) a halogen, or (3) a C 1-4  alkyl group which may be substituted with a halogen; R 7  and R 8  are each independently (1) a hydrogen atom, (2) a halogen, (3) a C 1-4  alkyl group which may be substituted with a halogen, or (4) a C 1-4  alkoxy group which may be substituted with a halogen, with the proviso that R 7  and R 8  are not simultaneously a hydrogen atom; Y is (1) a bond, (2) \u2014NH\u2014, or (3) \u2014O\u2014; Z is (1) a bond, (2) \u2014NR 12 \u2014, or (3) \u2014O\u2014; R 12  is (1) a hydrogen atom, (2) a C 1-4  alkyl group which may be substituted with a halogen, or (3) a C 2-5  acyl group which may be substituted with a halogen; R 10  and R 11  are each independently (1) a hydrogen atom or (2) a C 1-4  alkyl group which may be substituted with a halogen or a hydroxy group; n is an integer of 1 to 4, and when n is 2 to 4, a plurality of R 10 's or a plurality of R 11 's may be the same as or different from one another; R 9  is (1) a ring A, (2) a C 1-4  alkyl group, (3) a C 2-4  alkenyl group, (4) a C 2-4  alkynyl group, (5) \u2014C 1-4  alkylene group-ring A, (6) \u2014C 2-4  alkenylene group-ring A, (7) \u2014C 2-4  alkynylene group-ring A, (8) -ring B-ring C, (9) -ring B-C 1-4  alkylene group-ring C, (10) -ring B-C 2-4  alkenylene group-ring C, (11) -ring B-C 2-4  alkynylene group-ring C, or (12) -ring B-O-ring C, where the alkyl group, the alkenyl group, the alkynyl group, the alkylene group, the alkenylene group, or the alkynylene group each may be substituted with a halogen or a hydroxy group; the ring A is (1) a C 3-8  cycloalkane, (2) a 3- to 8-membered heterocycloalkane, (3) a C 3-12  monocyclic or bicyclic unsaturated carbocyclic ring or the carbocyclic ring which may be partially saturated, or (4) a 3- to 12-membered monocyclic or bicyclic unsaturated heterocycle containing one to four heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom or the heterocycle which may be partially saturated; the ring B and the ring C are each independently (1) a C 3-8  monocyclic cycloalkane, (2) a 3- to 8-membered monocyclic heterocycloalkane, (3) a C 3-7  monocyclic unsaturated carbocyclic ring or the carbocyclic ring which may be partially saturated, or (4) a 3- to 7-membered monocyclic unsaturated heterocycle containing one to three heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom or the heterocycle which may be partially saturated; where the ring A, the ring B, and the ring C may be each independently substituted with one to five R 13 's, and when a plurality of R 13 's is present, the R 13 's may be the same as or different from one another; R 13  is (1) a halogen, (2) a hydroxy group, (3) a cyano group, (4) a C 1-6  alkyl group which may be substituted with a halogen or a hydroxy group, (5) a C 1-6  alkoxy group which may be substituted with a halogen or a hydroxy group, or (6) an amino group which may be substituted with a C 1-4  alkyl group or a C 2-5  acyl group).

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.75439
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16059270', '10506746', '10583469', '12893592', '11500207']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7889106841946533
- 35 USC 102 Novelty (BERT): 0.5418697882926476
- Combined Prediction Score: 0.7642065946044527
- Mean Citation Score: 344.198492
- Max Citation Score: 371.80588
- Similarity Product: 309.94437884817364

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test