PATENT CLAIM ANALYSIS

Application Number: 16022031
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-02
Patent Classification: ["514", "234500"]

Abstract:
The present invention provides aza-heteroaryl derivatives of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A, W, R 4 , R 5 , and R 6  are defined herein, that inhibit the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Claim (Index 28):
The compound of  claim 1 , selected from:\n 2-(1H-Benzimidazol-2-yl)-6-(1-benzyl-1H-pyrazol-4-yl)-1,3-benzoxazole; 2-(1H-Benzimidazol-2-yl)-6-(1H-indazol-5-yl)-1,3-benzoxazole; 2-(1H-Benzimidazol-2-yl)-6-(3-methyl-1H-indazol-5-yl)-1,3-benzoxazole; 2-(1H-Benzimidazol-2-yl)-6-(3,4-difluorophenyl)-1,3-benzoxazole; 6-[1-(Ethylsulfonyl)-1H-indazol-6-yl]-2-(1H-benzimidazol-2-yl)-1,3-benzoxazole; 2-(1H-Benzimidazol-2-yl)-6-(2-ethyl-2H-indazol-6-yl)-1,3-benzoxazole; 2-(1H-Benzimidazol-2-yl)-6-(1-ethyl-1H-indazol-6-yl)-1,3-benzoxazole; 2-(1H-Benzimidazol-2-yl)-6-(4-benzylpiperazin-1-yl)-1,3-benzoxazole; 5-[2-(1H-Benzimidazol-2-yl)-1,3-benzoxazol-6-yl]-3-(trifluoromethyl)pyridin-2-amine; 6-[2-(1H-Benzimidazol-2-yl)-1,3-benzoxazol-6-yl]-1-ethyl-1H-pyrazolo[4,3-b]pyridine; 1-({5-[2-(1H-Benzimidazol-2-yl)-1,3-benzoxazol-6-yl]pyridin-3-yl}sulfonyl)pyrrolidin-3-ol; 5-[2-(1H-Benzimidazol-2-yl)-1,3-benzoxazol-6-yl]-N-ethylpyridine-3-sulfonamide; N-{5-[2-(1H-Benzimidazol-2-yl)-1,3-benzoxazol-6-yl]-2-fluorophenyl)}ethanesulfonamide; 1-(5-(2-(1H-Imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)-2,2,2-trifluoroethanol; 2-(4,5-Dimethyl-1H-imidazol-2-yl)-6-(5-(methylsulfonyl)pyridin-3-yl)benzo[d]oxazole; N-(5-(2-(4,5-Dimethyl-1H-imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)ethanesulfonamide; N-(5-(2-(5-Methyl-4-propyl-1H-imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)ethanesulfonamide; N-(5-(2-(4,5-Dimethyl-1H-imidazol-2-yl)benzo[d]oxazol-6-yl)-2-methoxypyridin-3-yl)ethanesulfonamide; N-(2-Methoxy-5-(2-(4,5,6,7-tetrahydro-1H-benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)ethanesulfonamide; 1-(5-(2-(4,5-Dimethyl-1H-imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)-2,2,2-trifluoroethanol; 2,2,2-Trifluoro-1-(5-(2-(4,5,6,7-tetrahydro-1H-benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)ethanol; 2-(1H-Benzo[d]imidazol-2-yl)-6-(6-fluoro-5-methoxypyridin-3-yl)benzo[d]oxazole; 2-(1H-Benzo[d]imidazol-2-yl)-6-(2-fluoropyrimidin-5-yl)benzo[d]oxazole; 2-(5-(2-(1H-Benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)acetic acid; 2-(1H-Benzo[d]imidazol-2-yl)-6-(5-(dimethylphosphoryl)pyridin-3-yl)benzo[d]oxazole; N-(5-(2-(1H-Benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)-N-methylethanesulfonamide; 1-(5-(2-(1H-Benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)-2,2,2-trifluoroethanol; N-(5-(2-(1H-Benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)-2-fluoropyridin-3-yl)-2,2,2-trifluoroethanesulfonamide; N-(5-(2-(1H-Benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)-2-methylpyridin-3-yl)-2,2,2-trifluoroethanesulfonamide; N-(5-(2-(1H-Benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)pyridin-3-yl)-2,2,2-trifluoroethanesulfonamide; N-(2-(2-(1H-Benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)-5-fluoropyridin-4-yl)ethanesulfonamide; N-(5-(2-(1H-Benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)-2-methoxypyridin-3-yl)ethanesulfonamide; and N-(5-(2-(1H-Benzo[d]imidazol-2-yl)benzo[d]oxazol-6-yl)-3-fluoro-2-methoxyphenyl)ethanesulfonamide; or a pharmaceutically acceptable salt of any of the aforementioned.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 94.0
- Lexical Diversity: 1.55769
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15019144', '13854789', '12972155', '15631417', '15065409']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8012566201811572
- 35 USC 102 Novelty (BERT): 0.5648302395810187
- Combined Prediction Score: 0.7776139821211434
- Mean Citation Score: 379.18514
- Max Citation Score: 453.30923
- Similarity Product: 376.4908811093235

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test