PATENT CLAIM ANALYSIS

Application Number: 16085972
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "359000"]

Abstract:
In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles, which are modulators the pregnane X receptor (“PXR”); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Claim (Index 1):
A compound having a structure represented by a formula: wherein R 1  is hydroxy, halogen, C1-C6 alkyl, C1-C6 alkoxy, and \u2014(C1-C6)-OH; wherein R 2  is halogen, cyano, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, \u2014CO 2 H, \u2014(C\u2550O)H, \u2014(C\u2550O)\u2014(C1-C6 alkyl), \u2014(C\u2550O)\u2014O(C1-C6 alkyl); wherein R 3  is hydroxy, halogen, C1-C6 alkyl, C1-C6 alkoxy, and \u2014(C1-C6)-OH; wherein R 4  is hydrogen, cyano, halogen, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, \u2014(C\u2550O)\u2014(C1-C6 alkyl), \u2014(C\u2550O)\u2014O(C1-C6 alkyl), \u2014(C1-C6 alkyl)-(C\u2550O)\u2014(C1-C6 alkyl), \u2014(C1-C6 alkyl)-(C\u2550O)\u2014O(C1-C6 alkyl), Ar 1 , or Cy 1 ;\n wherein Ar 1  is monocyclic aryl or monocyclic heteraryl substituted with 0, 1, 2, or 3 groups selected from halogen, hydroxy, cyano, amino, C1-C3 alkyl, C1-C3 hydroxyalkyl, C1-C3 monohaloalkyl, or C1-C3 polyhaloalkyl; \n wherein Cy 1  is C3-C8 cycloalkyl or C2-C7 heterocycloalkyl substituted with 0, 1, 2, or 3 groups selected from halogen, hydroxy, cyano, amino, C1-C3 alkyl, C1-C3 hydroxyalkyl, C1-C3 monohaloalkyl, or C1-C3 polyhaloalkyl; \n wherein R 5  is hydrogen, halogen, hydroxy, C1-C3 alkyl; wherein R 6  is hydrogen, halogen, hydroxy, C1-C3 alkyl; wherein R 7  is C1-C6 alkyl; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 97.0
- Lexical Diversity: 1.90909
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15519109', '16329168', '15554707', '14380659', '14421776']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.805268696050726
- 35 USC 102 Novelty (BERT): 0.5856265831121568
- Combined Prediction Score: 0.7833044847568691
- Mean Citation Score: 451.545598
- Max Citation Score: 478.9307
- Similarity Product: 427.67935190536974

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test