PATENT CLAIM ANALYSIS

Application Number: 16127772
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "242000"]

Abstract:
The present invention relates to compounds capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds, and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Claim (Index 41):
A compound of Formula I: wherein Y 1  is selected from CH and N; Y 2  is selected from CR 12  and N; Y 3  is selected from NH and CR 8 R 9 ; R 1  is selected from (C6-C10)aryl, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl and a 5-9 membered heteroaryl group containing from 1 to 4 heteroatoms selected from N, O and S; wherein said aryl or heteroaryl is optionally substituted with 1 to 5 R 10  groups; R 2a  and R 2b  are each independently selected from hydrogen, (C1-C4)alkyl, (C1-C4)alkoxy, amino, hydroxy, (C3-C8)cycloalkyl, (C1-C4)alkylamino and di(C1-C4)alkylamino; R 3  is hydrogen, fluoro or (C1-C4)alkyl; R 4a  and R 4b  are each independently selected from hydrogen, halo, carbonyl, (C1-C4)alkyl, (C1-C4)alkoxy, amino, hydroxy, (C3-C8)cycloalkyl, (C1-C4)alkylamino and di(C1-C4)alkylamino; R 5a  and R 5b  are each independently selected from are independently selected from hydrogen, halo, carbonyl, (C1-C4)alkyl, (C1-C4)alkoxy, amino, hydroxy, (C3-C8)cycloalkyl, (C1-C4)alkylamino and di(C1-C4)alkylamino; R 6  is selected from is hydrogen, fluoro or (C1-C4)alkyl; R 7a  and R 7b  are each independently selected from hydrogen, carbonyl, (C1-C4)alkyl, (C1-C4)alkoxy, amino, hydroxy, (C3-C8)cycloalkyl, (C1-C4)alkylamino and di(C1-C4)alkylamino; R 8  is selected from hydrogen, (C1-C4)alkyl, (C3-C6)cycloalkyl, (C6-10)aryl and a 5-9 member heteroaryl group containing from 1 to 4 heteroatoms selected from N, O and S; R 9  is selected from NH2, (C1-C4)alkylamino, di(C1-C4)alkylamino, NH2-(CH2)-, (C1-C4)alkyl-NH\u2014(CH2)-, and di[(C1-C4)alkyl]N-(CH2)-; Each R 10  is independently selected from halo, amino, hydroxy, N3, (C1-C4)alkyl, hydroxy-substituted-(C1-C4)alkyl, halo-substituted-(C1-C4)alkyl, amino-substituted-(C1-C4)alkyl, \u2014C(O)OR 11  and \u2014NHC(O)R 11 ; Each R 11  is independently selected from hydrogen, phenyl and naphthyl; wherein said phenyl is optionally substituted with methoxy; R 12  is selected from hydrogen, halo, cyano, (C1-C4)alkyl, (C1-C4)alkoxy, amino-carbonyl, halo-substituted (C1-C4)alkyl, halo-substituted (C1-C4)alkoxy, hydroxy-substituted (C1-C4)alkyl, amino-substituted (C1-C4)alkyl, \u2014S(\u2550O)R 12a , \u2014SO2R 12a , \u2014C(\u2550S)R 12a , \u2014C(\u2550O)NR 12a R 12b , \u2014C(NH)NR 12a R 12b  and \u2014NR 12a C(\u2550O)R 12b ; wherein each R 12a  and R 12b  are independently selected from hydrogen and (C1-C4)alkyl; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 128.0
- Percentile: 97.0
- Lexical Diversity: 1.61111
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14554263', '14155134', '15358371', '14554306', '15398907']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7531624360380942
- 35 USC 102 Novelty (BERT): 0.5239844125667867
- Combined Prediction Score: 0.7302446336909635
- Mean Citation Score: 305.715376
- Max Citation Score: 310.1815200000001
- Similarity Product: 228.81633620760448

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test