PATENT CLAIM ANALYSIS

Application Number: 15994074
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "186100"]

Abstract:
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

Claim (Index 19):
The modified virus of  claim 1 , wherein the deoptimized viral nucleic acid comprises a coding sequence having at least 90% sequence identity to any of SEQ ID NOS: 5, 8, 11, 14, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 54, 55, 56, 57, 58, 67, 68, or 69 or wherein the deoptimized viral nucleic acid comprises a coding sequence of any of SEQ ID NOS: 5, 8, 11, 14, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 54, 55, 56, 57, 58, 67, 68, or 69.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 93.0
- Lexical Diversity: 1.57895
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11576941', '12594173', '14766620', '15315687', '15508695']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7012535310645266
- 35 USC 102 Novelty (BERT): 0.7364836754161831
- Combined Prediction Score: 0.7047765454996923
- Mean Citation Score: 435.261758
- Max Citation Score: 906.7351
- Similarity Product: 785.3754361564636

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test