PATENT CLAIM ANALYSIS

Application Number: 16248507
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["424", "172100"]

Abstract:
The instant disclosure provides antibodies that specifically bind to ApoC3 (e.g., human ApoC3) and antagonize ApoC3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Claim (Index 10):
The isolated antibody of  claim 1 , wherein the antibody further comprises a human constant region, optionally wherein:\n (a) the constant region is a variant of a wild type human immunoglobulin heavy chain constant region, and wherein the variant human immunoglobulin heavy chain constant region has an increased affinity for human neonatal Fc receptor (FcRn) at pH 6 relative to the affinity of the corresponding wild type human immunoglobulin heavy chain constant region for human FcRn at pH 6; (b) the constant region is a human IgG, optionally a human IgG 1 , IgG 2 , or IgG 4 ; (c) the constant region comprises the amino acids K, F, and Y at EU positions 433, 434, and 436, respectively; (d) the constant region comprises the amino acids Y, T, and E at EU positions 252, 254, and 256, respectively; (e) the constant region comprises the amino acids L and S at EU positions 428 and 434, respectively; or (f) the constant region comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 22-24, 76-78, and 81-86.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 99.0
- Lexical Diversity: 1.36585
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15606148', '15254315', '15166305', '16165833', '15524651']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7938880774909929
- 35 USC 102 Novelty (BERT): 0.5510769598982289
- Combined Prediction Score: 0.7696069657317165
- Mean Citation Score: 428.60382800000014
- Max Citation Score: 446.3738
- Similarity Product: 345.2423157553554

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test