PATENT CLAIM ANALYSIS

Application Number: 16186879
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-02
Patent Classification: ["514", "001400"]

Abstract:
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.

Claim (Index 1):
A compound of formula wherein\n X is selected from the group consisting of \u2014CH 2 \u2014S\u2014S\u2014CH 2 \u2014, \u2014C(CH 3 ) 2 \u2014S\u2014S\u2014CH 2 \u2014, \u2014CH 2 \u2014S\u2014S\u2014C(CH 3 ) 2 \u2014, \u2014C(CH 3 ) 2 \u2014S\u2014S\u2014C(CH 3 ) 2 \u2014, \u2014(CH 2 ) 2 \u2014S\u2014S\u2014CH 2 \u2014, \u2014CH 2 \u2014S\u2014S\u2014(CH 2 ) 2 \u2014, \u2014(CH 2 ) 2 \u2014S\u2014S\u2014(CH 2 ) 2 \u2014, \u2014C(CH 3 ) 2 \u2014S\u2014S\u2014(CH 2 ) 2 \u2014, \u2014(CH 2 ) 2 \u2014S\u2014S\u2014C(CH 3 ) 2 , \u2014(CH 2 ) t \u2014C(O)\u2014NR 8 \u2014(CH 2 ) r \u2014 and \u2014(CH 2 ) r \u2014NR 8 \u2014C(O)\u2014(CH 2 ) t \u2014; \n R 1  and R 2  each is, independently for each occurrence thereof, H, (C 1 -C 10 )alkyl or substituted (C 1 -C 10 )alkyl; \n R 3  is \u2014OH or \u2014NH 2 ; \n R 4  and R 5  each is, independently for each occurrence thereof, H, (C 1 -C 10 )alkyl or substituted (C 1 -C 10 )alkyl; \n X 1  is \n A 1  is His, 2-Pal, 3-Pal, 4-Pal, Taz, 2-Thi, 3-Thi, (X 1 , X 2 , X 3 , X 4 , X 5 )Phe or deleted; A 2  is D-Bal, D-1-Nal, D-2-Nal, D-Phe or D-(X 1 , X 2 , X 3 , X 4 , X 5 )Phe; A 3  is Arg, hArg, Dab, Dap, Lys or Orn; A 4  is Bal, 1-Nal, 2-Nal, (X 1 , X 2 , X 3 , X 4 , X 5 )Phe or Trp; R 6  and R 7  each is, independently for each occurrence thereof, H, (C 1 -C 10 )alkyl, (C 1 -C 10 )heteroalkyl, aryl(C 1 -C 5 )alkyl, substituted (C 1 -C 10 )alkyl, substituted (C 1 -C 10 )heteroalkyl or substituted aryl(C 1 -C 5 )alkyl or R 6  and R 7  may be joined together form a cyclic moiety; R 8  is H, (C 1 -C 10 )alkyl or substituted (C 1 -C 10 )alkyl; r is, independently for each occurrence thereof, 1, 2, 3, 4 or 5; and t is, independently for each occurrence thereof, 1 or 2; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 98.0
- Lexical Diversity: 1.46875
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12602010', '14024961', '13074565', '11988468', '15055873']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8929163480589772
- 35 USC 102 Novelty (BERT): 0.6652262376510306
- Combined Prediction Score: 0.8701473370181826
- Mean Citation Score: 625.486862
- Max Citation Score: 672.6033
- Similarity Product: 641.7207945551634

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test