PATENT CLAIM ANALYSIS

Application Number: 15970457
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-08
Patent Classification: ["544", "317000"]

Abstract:
Disclosed are substituted aromatic N-heterocyclic compounds. The disclosed compounds typically exhibit kinase inhibition activity, for example, and inhibit Mnk1 kinase and/or Mnk2 kinase. The disclosed compounds may be used in pharmaceutical compositions and methods for treating diseases or disorders associated with Mnk1 kinase activity and/or Mnk2 kinase activity, such as cancers, diabetes, autism, and fragile X syndrome.

Claim (Index 1):
A compound having Formula I: wherein: X 1 , X 2 , X 3 , and X 4  are the same or different and are C or N, at least one of X 1 , X 2 , X 3 , and X 4  is N and preferably no more than two of X 1 , X 2 , X 3 , and X 4  is N; Z is N, O, or CH; n is 0-6 and optionally (CH 2 ) n  is substituted with alkyl and forms a branched alkyl substituent; R 1  is hydrogen; alkyl; alkyoxy; hydroxyl; hydroxyalkyl; carboxyl; carboxyalkyl ester; carboxyalkyl amido; cycloalkyl optionally substituted at one or more positions with hydroxyl, alkyl, alkoxyl, amino, alkylamino, or carboxyl; bicycloalkyl; amino optionally substituted with alkyl; carboxy amido optionally substituted with phenyl or substituted phenyl; thioamido; or R 1  is one 3-membered, one 4-membered ring, 5-membered ring, one 6-membered ring, or one 7-membered ring which ring is optionally saturated or unsaturated, or R 1  is two fused rings which may be 5-membered rings or 6-membered rings which rings are optionally saturated or unsaturated, which one ring or rings are carbocycles or heterocycles including one or more heteroatoms, which one ring or rings optionally are substituted to include one or more non-hydrogen substituents, which non-hydrogen substituents optionally are selected from alkyl, halo, haloalkyl, hydroxyl, phenyl, amino, and carbonyl; R 2  is hydrogen, alkyl, or R 2  and R 1  together form one 5-membered ring, one 6-membered ring, or one 7-membered ring which ring is optionally saturated or unsaturated, or R 2  and R 1  together form two fused rings which may be 5-membered rings or 6-membered rings which rings are optionally saturated or unsaturated, which ring or rings are carbocycles or heterocycles including one or more heteroatoms, which ring or rings optionally are substituted to include one or more non-hydrogen substituents, which non-hydrogen substituents optionally are selected from alkyl, halo, haloalkyl, hydroxyl, phenyl, amino, carbonyl, N-pyrrolidinyl, or caprolactam; R 3  has a structure selected from R 3  is *\u2014O-alkyl-R 3\u2032  or *\u2014NH-alkyl-R 3\u2032 , wherein R 3\u2032  is hydroxyl, phenyl, pyridinyl, indolyl, or pyrrolidonyl optionally substituted at one or more positions with halo; R 4  and R 4\u2032  are selected from hydrogen, alkyl, cycloalkyl; haloalkyl, halo, alkoxy, cyano, amino, hydroxyl, carboxyl, carboxy alkyl ester, phenyl optionally substituted with alkoxy, haloalkoxy, and benzamido; R 5  is hydrogen, alkyl, cycloalkyl, amino, carboxyl, carboxy alkyl ester, carboxy amido, carboxy alkyl amido, or N-benzimidazole; R 6  is hydrogen, alkyl, phenyl optionally substituted at one or more positions with alkyoxy or halo, tetrahydropuranyl, alkylmorpholinyl, and benzyl; R 7  is hydrogen, or alkyl; R 8  is hydrogen or phenyl optionally substituted at one or more positions with alkyoxy; and Y 1 , Y 2 , Y 3 , and Y 4  are the same or different and are selected from C or N and preferably no more than two or three of Y 1 , Y 2 , Y 3 , and Y 4  are N; R 9 , R 10 , R 11 , R 12 , and R 13  are the same or different and are hydrogen, alkyl, alkoxy, halo, haloalkyl, nitro, carboxylalkyl ester, or phenyl; R 14 , R 15 , and R 16  are the same or different and are hydrogen, alkyl, halo, haloalkyl, cyano, or phenyl optionally substituted with halo or haloalkyl.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 93.0
- Lexical Diversity: 1.53488
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15337332', '15858733', '14527328', '15545598', '12378195']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8119906513886974
- 35 USC 102 Novelty (BERT): 0.5599798442156151
- Combined Prediction Score: 0.7867895706713892
- Mean Citation Score: 354.8572660000001
- Max Citation Score: 449.72232
- Similarity Product: 373.2395226961614

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test