PATENT CLAIM ANALYSIS

Application Number: 16009943
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "218000"]

Abstract:
Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also disclosed are pharmaceutical compositions comprising at least one such compound, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

Claim (Index 158):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, represented by formula XXVI: wherein: X represents CH, C(OH), \u2014C(NH 2 ), or \u2014C(NR a R b ); \u2014Y\u2014R 4 , when present, represents \u2014((C 1 -C 6 )alkyl)-R 4 , \u2014CH 2 C(O)\u2014R 4 , \u2014CH 2 NH\u2014R 4 , \u2014CH 2 N((C 1 -C 6 )alkyl)-R 4 , \u2014CR a R b \u2014R 4 , \u2014NH\u2014R 4 , \u2014NHCH 2 \u2014R 4 , \u2014NHC(O)\u2014R 4 , \u2014N((C 1 -C 6 )alkyl)-R 4 , \u2014N((C 1 -C 6 )alkyl)CH 2 \u2014R 4 , \u2014N((CH 2 ) 20 H)\u2014R 4 , \u2014N[(C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl]R 4 , -heterocyclyl-R 4 , \u2014OR 4 , \u2014OCH 2 \u2014R 4 , \u2014OC(O)\u2014R 4 , \u2014OC(O)NR a R b , \u2014SCH 2 R 4 , or \u2014SR 4 , wherein the (C 1 -C 6 )alkyl moiety of \u2014((C 1 -C 6 )alkyl)-R 4  is optionally substituted; Z is absent or represents halo, hydroxy, (C 1 -C 6 )alkyl, \u2014CF 3 , \u2014OCF 3 , (C 1 -C 6 )alkoxy, aryl, aryloxy, amino, amino(C 1 -C 6 )alkyl, \u2014C(O)NH 2 , cyano, \u2014NHC(O)(C 1 -C 6 )alkyl, \u2014SO 2 (C 1 -C 6 )alkyl, \u2014SO 2 NH 2 , or (C 3 -C 8 )cycloalkyl; R 1c  represents halo, amino(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, cyano, \u2014SO 2 CH 3 , formyl, acyl, \u2014NH 2 , or optionally substituted aryl; R 3a  is absent or represents one or more substituents independently selected from the group consisting of halo, hydroxy, (C 1 -C 6 )alkyl, \u2014CF 3 , \u2014OCF 3 , (C 1 -C 6 )alkoxy, aryl, aryloxy, amino, amino(C 1 -C 6 )alkyl, \u2014C(O)NH 2 , cyano, \u2014NHC(O)(C 1 -C 6 )alkyl, \u2014SO 2 (C 1 -C 6 )alkyl, and \u2014SO 2 NH 2 ; and R 4  represents hydrogen, hydroxy, optionally substituted (C 1 -C 6 )alkyl, optionally substituted (C 3 -C 8 )cycloalkyl, heterocyclyl(C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, \u2014CH 2 OH, \u2014CH((C 1 -C 6 )alkyl)OH, \u2014CH(NH 2 )CH((C 1 -C 6 )alkyl) 2 , optionally substituted aryl, optionally substituted aryl(C 1 -C 6 )alkyl, heteroaryl, optionally substituted heteroaryl(C 1 -C 6 )alkyl, \u2014CH 2 S(C 1 -C 6 )alkyl, amino, or cyano; or \u2014CH 2 \u2014 fused to the 4-position of the ring bearing Z to form a 5- to 7-membered heterocyclic ring with optional substituents; or, when R 3  is phenyl, can represent \u2014NH\u2014 fused to the position ortho to X on that phenyl.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 94.0
- Lexical Diversity: 1.4186
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15123059', '15764071', '10571212', '12774544', '13048832']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8517848463041947
- 35 USC 102 Novelty (BERT): 0.584785114333178
- Combined Prediction Score: 0.8250848731070931
- Mean Citation Score: 406.383022
- Max Citation Score: 495.47354
- Similarity Product: 452.0708588653124

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test