PATENT CLAIM ANALYSIS

Application Number: 15760971
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "064000"]

Abstract:
Disclosed herein are compounds comprising dicarba-closo-dodecaborane. The compounds can be, for example, estrogen receptor beta (ERβ) agonists. In some examples, the compounds can be selective ERβ agonists. Also provided herein are methods of treating, preventing, or ameliorating cancer in a subject, suppressing tumor growth in a subject, treating an inflammatory disease in a subject, treating a neurodegenerative disease in a subject, treating a psychotropic disorder in a subject, or a combination thereof by administering to a subject a therapeutically effective amount of one or more of the compounds or compositions described herein, or a pharmaceutically acceptable salt thereof.

Claim (Index 41):
A compound of Formula VIII, or a pharmaceutically acceptable salt thereof: wherein Q is a substituted or unsubstituted dicarba-closo-dodecaborane cluster, and and R 13  are attached to Q in a para configuration;\n X is OH, NHR 2 , SH, or S(O)(O)NHR 2 ; \n R 13  is substituted or unsubstituted C 1 -C 9  alkyl, substituted or unsubstituted C 2 -C 19  alkenyl, substituted or unsubstituted C 2 -C 19  alkynyl, or substituted or unsubstituted C 1 -C 20  acyl; and \n R 14 , R 15 , and R 16  are independently hydrogen, halogen, hydroxyl, substituted or unsubstituted C 1 -C 18  alkyl, substituted or unsubstituted C 2 -C 18  alkenyl, substituted or unsubstituted C 1 -C 18  alkynyl, substituted or unsubstituted C 2 -C 18  aryl, substituted or unsubstituted C 3 -C 18  cycloalkyl, substituted or unsubstituted C 1 -C 20  acyl, or NR 3 R 4 , or wherein, as valence permits, R 14  and R 15 , R 14  and R 6 , or R 15  and R 16 , together with the atoms to which they are attached, for a 3-10 membered substituted or unsubstituted cyclic moiety optionally including from 1 to 3 heteroatoms, \n with the proviso that at least two of R 14 , R 15  and R 16  are not hydrogen, halogen, or hydroxyl; and \n with the proviso that when X is OH and R 13  is a C 5  alkyl, R 14 , R 15 , and R 6  are not H, methyl, and methyl.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 90.0
- Lexical Diversity: 1.88525
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13439991', '14352210', '15453953', '14090158', '10594483']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7578642905608353
- 35 USC 102 Novelty (BERT): 0.5091592976143806
- Combined Prediction Score: 0.7329937912661899
- Mean Citation Score: 268.98001800000003
- Max Citation Score: 282.6429
- Similarity Product: 210.6058900983453

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test