PATENT CLAIM ANALYSIS

Application Number: 15885258
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["534", "558000"]

Abstract:
The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 2 ′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON). The disclosure also provides compounds having formula (I) for use in treating cancer.

Claim (Index 1):
A compound having formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n X is selected from the group consisting of a bond, \u2014O\u2014, and \u2014(CH 2 ) n \u2014, wherein n is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, and 8; \n R 1  is selected from the group consisting of H, C 1-6  alkyl, and substituted C 1-6  alkyl; \n R 2  is an amino acid, an N-substituted amino acid, or \u2014C(\u2550O)\u2014O\u2014(CR 3 R 4 ) m \u2014O\u2014C(\u2550O)\u2014R 10 ; \n R 2 \u2032 is selected from the group consisting of H, C 1 -C 6  alkyl, and substituted C 1 -C 6  alkyl; \n each R 3  and R 4  are independently H, C 1 -C 6  alkyl, substituted C 1 -C 6  alkyl, aryl, substituted aryl, \u2014(CR 3 R 4 ) m \u2014NR 5 R 6 , or \n m is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, and 8; R 5  and R 6  are independently H or alkyl; and R 10  is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, monosaccharide, acylated monosaccharide, aryl, substituted aryl, heteroaryl, and substituted heteroaryl.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.68889
- Patent Class: 534.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15885147', '15502105', '15419642', '15318627', '11150500']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6861137522489297
- 35 USC 102 Novelty (BERT): 0.5499912305552367
- Combined Prediction Score: 0.6725015000795604
- Mean Citation Score: 331.99464
- Max Citation Score: 421.0206
- Similarity Product: 368.7099219235897

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test