PATENT CLAIM ANALYSIS

Application Number: 15870557
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "230500"]

Abstract:
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

Claim (Index 1):
A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein,\n Ring A is an optionally substituted 5- or 6-membered heteroaryl ring containing at least one S or N atom, or an optionally substituted 5- or 6-membered heterocyclyl ring containing at least one S or N atom; \n X2 is N or C\u2014R 12 , in which R 12  is hydrogen, halogen, alkyl, or alkoxy; \n X5 is N or C\u2014R 15 , in which R 15  is hydrogen, halogen, \u2014CN, \u25a1lk\u25a1l \u25a1r \u25a1lk\u25a1x\u25a1; \n X6 is N or C\u2014R 16 , in which R 16  is hydrogen, halogen, or \u2014W\u2014X, wherein W is a bond, \u2014O\u2014, \u2014S\u2014, or \u2014NH\u2014, and X is alkyl, alkynyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkynyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and \n G is: \n wherein,\n R 22  is alkyl; \n R 23  is hydrogen, halogen, or alkyl; or optionally, when R 23  is alkyl, R 22  and R 23  join to form an optionally substituted ring; \n R 25  is hydrogen, halogen, alkyl, alkoxy, or alkenyl; \n R 26  is hydrogen, halogen, alkyl, alkoxy, aminoalkyl, or alkenyl; or optionally, when R 23  is hydrogen, R 25  is not hydrogen and R 26  is not hydrogen or halogen, R 25  and R 26  join to form an optionally substituted ring; \n provided that the compound of Formula I is not:\n 4-(3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-2-methylisoquinolin-1(2H)-one; \n 2-methyl-4-(2-oxoindolin-6-yl)isoquinolin-1(2H)-one; \n 4-methyl-6-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-2H-benzo[b][1,4]oxazin-3 (4H)-one; or \n 4-(1\u2032-cyclobutyl-4H-spiro[benzo[d][1,3]dioxine-2,4\u2032-piperidine]-6-yl)-2-methylisoquinolin-1(2H)-one.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 86.0
- Lexical Diversity: 1.425
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15130503', '14517705', '15488674', '14658048', '14789881']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8531941133253651
- 35 USC 102 Novelty (BERT): 0.5878761204741008
- Combined Prediction Score: 0.8266623140402387
- Mean Citation Score: 490.161302
- Max Citation Score: 508.7241
- Similarity Product: 443.8386122109711

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test