PATENT CLAIM ANALYSIS

Application Number: 16024558
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-04
Patent Classification: ["514", "04400A"]

Abstract:
The invention relates a method wherein a molecule is used for inducing and/or promoting skipping of at least one of exon 43, exon 46, exons 50-53 of the DMD pre-mRNA in a patient, preferably in an isolated cell of a patient, the method comprising providing said cell and/or said patient with a molecule. The invention also relates to said molecule as such.

Claim (Index 1):
An isolated antisense oligonucleotide which is fully complementary to 8-22 consecutive nucleotides of a sequence of an exon of human dystrophin pre-mRNA, said oligonucleotide comprising a locked nucleic acid, wherein said sequence of said exon is selected from the group consisting of:\n 5\u2032-AGAUAGUCUACAACAAAGCUCAGGUCGGAUUGACAUUAUUCAUAG CAAGAAGACAGCAGCAUUGCAAAGUGCAACGCCUGUGG-3\u2032 (SEQ ID NO: 2), and wherein said oligonucleotide is capable of skipping exon 43; 5\u2032-UUAUGGUUGGAGGAAGCAGAUAACAUUGCUAGUAUCCCACUUGAA CCUGGAAAAGAGCAGCAACUAAAAGAAAAGC-3\u2032 (SEQ ID NO: 3), and wherein said oligonucleotide is capable of skipping exon 46; 5\u2032-GCGGTAAACCGUUUACUUCAAGAGCUGAGGGCAAAGCAGCCUGAC CUAGCUCCUGGACUGACCACUAUUGG-3\u2032 (SEQ ID NO: 4), and wherein said oligonucleotide is capable of skipping exon 50; 5\u2032-CUCCUACUCAGACUGUUACUCUGGUGACACAACCUGUGGUUACUA AGGAAACUGCCAUCUCCAAACUAGAAAUGCCAUCUUCCUUGAUG UUGGAGGUAC-3\u2032 (SEQ ID NO: 5), and wherein said oligonucleotide is capable of skipping exon 51; 5\u2032-AUGCAGGAUUUGGAACAGAGGCGUCCCCAGUUGGAAGAACUCAUU ACCGCUGCCCAAAAUUUGAAAAACAAGACCAGCAAUCAAGAGGCU-3\u2032 (SEQ ID NO:6), and wherein said oligonucleotide is capable of skipping exon 52, and 5\u2032-AAUGUUAAAGGAUUCAACACAAUGGCUGGAAGCUAAGGAAAAGCU GAGCAGGUCUUAGGACAGGCCAGAG-3\u2032 (SEQ ID NO:7), and wherein said oligonucleotide is capable of skipping exon 53.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 94.0
- Lexical Diversity: 1.61905
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15468239', '12605276', '12992218', '14248279', '15428385']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7557504731754575
- 35 USC 102 Novelty (BERT): 0.5357894458649172
- Combined Prediction Score: 0.7337543704444035
- Mean Citation Score: 367.672316
- Max Citation Score: 377.07214
- Similarity Product: 315.9421094700552

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test