PATENT CLAIM ANALYSIS

Application Number: 15872831
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["435", "006120"]

Abstract:
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

Claim (Index 20):
The method of  claim 19 , further comprising, for each mappable base position, calculating a ratio of (a) a number of aligned unique sequence reads that include a variant as compared to the reference sequence, and (b) a total number of aligned unique sequence reads.

Metadata:
- Claim Count in Document: 77.0
- Percentile: 86.0
- Lexical Diversity: 1.84286
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15467570', '14425189', '15076565', '14712754', '15492659']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6890280692380321
- 35 USC 102 Novelty (BERT): 0.569403530886978
- Combined Prediction Score: 0.6770656154029266
- Mean Citation Score: 540.457608
- Max Citation Score: 565.2374
- Similarity Product: 352.8881546850443

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test