PATENT CLAIM ANALYSIS

Application Number: 16075514
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "254000"]

Abstract:
The present disclosure provides a posaconazole derivative, a pharmaceutical composition and use thereof, which specifically include a compound represented by the following formula (I), a racemate, stereoisomer, tautomer, oxynitride, or a pharmaceutically acceptable salt thereof: The compounds of the present disclosure have strong antifungal activity, high safety, and good water solubility, without the need for the addition of a cosolvent (such as hydroxypropyl-β-cyclodextrin, sulfobutyl ether-β-cyclodextrin, and the like) with potential safety risks. Furthermore, the formulation process of the compound could have less difficulty and less cost, and therefore can be used to prepare improved antifungal drugs.

Claim (Index 8):
The method according to  claim 7 , including but not limited to at least one of the following reactions: preferably, wherein, R\u2032 represents R 4 , R h , X 1 , X 2 , X 3 , Y 3 , Y 4 , and PG have the definitions as described above; X 3 \u2032 represents an organic substituent that can be converted to X 3 ; L 3  and L 4  independently from each other are selected from leaving groups such as F, Cl, Br, or I; preferably, the reaction, for example the reaction 4) can be carried out in the presence of a catalyst such as NaBr, NaI or a mixture thereof.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 96.0
- Lexical Diversity: 1.56
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12226286', '12421230', '15380836', '10984522', '10984093']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.758744507955975
- 35 USC 102 Novelty (BERT): 0.5220497721160403
- Combined Prediction Score: 0.7350750343719815
- Mean Citation Score: 272.868316
- Max Citation Score: 278.55414
- Similarity Product: 180.98573596613647

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test