PATENT CLAIM ANALYSIS

Application Number: 15950965
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["514", "221000"]

Abstract:
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Claim (Index 1):
A method for treating a disease or disorder in a target tissue in a subject,\n wherein symptoms of the disease or disorder are caused at least in part by senescent cells that are located in or around the target tissue, wherein the target tissue is devoid of cancer, and wherein the senescent cells are defined as cells that express p16, the method comprising administering in or around the target tissue a course of therapy with a pharmaceutical composition, wherein the pharmaceutical composition includes a formulation of an amount of senolytic agent that is less than 10,000 mol. wt., wherein the amount of the senolytic agent and the formulation of the composition configure the composition such that upon administration to the target tissue in the subject, the senolytic agent contacts the senescent cells located in or around the target tissue, and selectively removes such senescent cells in preference to adjacent non-senescent cells, wherein the course of therapy includes a treatment period with the pharmaceutical composition, followed by a therapeutic period of at least two weeks during which the pharmaceutical composition is not administered but the symptoms of the disease or disorder in the target tissue are alleviated.

Metadata:
- Claim Count in Document: 45.0
- Percentile: 91.0
- Lexical Diversity: 1.58333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15114762', '15827539', '15647688', '15455684', '15467129']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8493138152911869
- 35 USC 102 Novelty (BERT): 0.6681563465549406
- Combined Prediction Score: 0.8311980684175622
- Mean Citation Score: 706.4160320000003
- Max Citation Score: 751.4263
- Similarity Product: 619.5335798981072

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test