PATENT CLAIM ANALYSIS

Application Number: 15988920
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "275000"]

Abstract:
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.

Claim (Index 1):
A compound of formula I, or salt thereof, wherein:\n X and Y are each independently O, S, S(O), SO 2  or NR 1 ; \n each R 1  is independently for each occurrence H, optionally substituted C 1-6 alkyl, C(O)\u2014C 1-6 alkyl, CO 2 \u2014C 1-6 alkyl or R 50 ; \n each R 50  is \u2014C(R 9 ) 2 -A-R 10 , where A is O or S; each R 9  is independently for each occurrence H, optionally substituted C 1-6 alkyl, optionally substituted C 6-10 aryl or optionally substituted C 7-16 arylalkyl; or alternatively, two R 9 , together with the carbon to which they are attached, form an optionally substituted C 3-8 cycloalkyl group or an optionally substituted 3-8 membered heteroalicyclyl; R 10  is R a  or \u2014P(O)(OR 11 ) 2 ; each R 11  is independently for each occurrence R a  or a monovalent cationic group; or two R 11 , together with the atoms to which they are attached, form a 4-8 membered cyclic phosphate group, or two R 11  together represent a divalent cationic group; \n ring A is bicyclic; \n each R 2  is independently for each occurrence H, R e , R b , R e  substituted with one or more of the same or different R a  and/or R b , \u2014OR e  substituted with one or more of the same or different R a  and/or R b , \u2014SR e  substituted with one or more of the same or different R a  and/or R b , \u2014C(O)R e  substituted with one or more of the same or different R a  and/or R b , \u2014N(R a )R e  where R e  is substituted with one or more of the same or different R a  and/or R b , \u2014S(O) 2 R e  substituted with one or more of the same or different R a  and/or R b , \u2014N(R a )\u2014S(O) 2 R e  where R e  is substituted with one or more of the same or different R a  and/or R b , \u2014B(OR a ) 2 , \u2014B(N(R c ) 2 ) 2 , \u2014(C(R a ) 2 ) m \u2014R b , \u2014O\u2014(C(R a ) 2 ) m \u2014R b , \u2014S\u2014(C(R a ) 2 ) m \u2014R b , \u2014O\u2014(C(R b ) 2 ) m \u2014R a , \u2014N(R a )\u2014(C(R a ) 2 ) m \u2014R b , \u2014O\u2014(CH 2 ) m \u2014CH((CH 2 ) m R b )R b , \u2014C(O)N(R a )\u2014(C(R a ) 2 ) m \u2014R b , \u2014O\u2014(C(R a ) 2 ) m \u2014C(O)N(R a )\u2014(C(R a ) 2 ) m \u2014R b , \u2014N((C(R a ) 2 ) m R b ) 2 , \u2014S\u2014(C(R a ) 2 ) m \u2014C(O)N(R a )\u2014(C(R a ) 2 ) m \u2014R b , \u2014N(R a )\u2014C(O)\u2014N(R a )\u2014(C(R a ) 2 ) m \u2014R b , \u2014N(R a )\u2014C(O)\u2014 (C(R a ) 2 ) m \u2014C(R a )(R b ) 2  or \u2014N(R a )\u2014(C(R a ) 2 ) m \u2014C(O)\u2014N(R a )\u2014(C(R a ) 2 ) m \u2014R b ; \n each R a  is independently for each occurrence H, deuterium, C 1-6 alkyl, C 3-8 cycloalkyl, C 4-11 cycloalkylalkyl, C 6-10 aryl, C 7-16  arylalkyl, 2-6 membered heteroalkyl, 3-10 membered heteroalicyclyl, 4-11 membered heteroalicyclylalkyl, 5-15 membered heteroaryl or 6-16 membered heteroarylalkyl; \n each R b  is independently for each occurrence \u2550O, \u2014OR a , \u2014O\u2014(C(R a ) 2 ) m \u2014OR a , haloC 1-3 alkyloxy, \u2550S, \u2014SR a , \u2550NR a , \u2550NOR a , \u2014N(R c ) 2 , halo, \u2014CF 3 , \u2014CN, \u2014NC, \u2014OCN, \u2014SCN, \u2014NO, \u2014NO 2 , \u2550N 2 , \u2014N 3 , \u2014S(O)R a , \u2014S(O) 2 R a , \u2014SO 3 R a , \u2014S(O)N(R c ) 2 , \u2014S(O) 2 N(R c ) 2 , \u2014OS(O)R a , \u2014OS(O) 2 R a , \u2014OSO 3 R a , \u2014OS(O) 2 N(R c ) 2 , \u2014C(O)R a , \u2014CO 2 R a , \u2014C(O)N(R c ) 2 , \u2014C(NR a )\u2014N(R c ) 2 , \u2014C(NOH)\u2014R a , \u2014C(NOH)\u2014N(R c ) 2 , \u2014OC(O)R a , \u2014OC(O)OR a , \u2014OC(O)N(R c ) 2 , \u2014OC(NH)\u2014N(R c ) 2 , \u2014OC(NR a )\u2014N(R c ) 2 , \u2014N(R a )\u2014S(O) 2 H, \u2014[N(R a )C(O)] n R a , \u2014[N(R a )C(O)] n OR a , \u2014[N(R a )C(O)] n N(R c ) 2  or \u2014[N(R a )C(NR a )] n \u2014N(R c ) 2 ; \n each R c  is independently for each occurrence R a , or, alternatively, two R c  are taken together with the nitrogen atom to which they are bonded to form a 3 to 10-membered heteroalicyclyl or a 5-10 membered heteroaryl which may optionally include one or more of the same or different additional heteroatoms and which is optionally substituted with one or more of the same or different R a  and/or R d  groups; \n each R d  is \u2550O, \u2014OR a , haloC 1-3 alkyloxy, C 1-6 alkyl, \u2550S, \u2014SR a , \u2550NR a , \u2550NOR a , \u2014N(R a ) 2 , halo, \u2014CF 3 , \u2014CN, \u2014NC, \u2014OCN, \u2014SCN, \u2014NO, \u2014NO 2 , \u2550N 2 , \u2014N 3 , \u2014S(O)R a , \u2014S(O 2 )R a , \u2014SO 3 R a , \u2014S(O)N(R a ) 2 , \u2014S(O) 2 N(R a ) 2 , \u2014OS(O)R a , \u2014OS(O) 2 R a , \u2014OSO 3 R a , \u2014OS(O) 2 N(R a ) 2 , \u2014C(O)R a , \u2014CO 2 R a , \u2014C(O)N(R a ) 2 , \u2014C(NR a )N(R a ) 2 , \u2014C(NOH)R a , \u2014C(NOH)N(R a ) 2 , \u2014OCO 2 R a , \u2014OC(O)N(R a ) 2 , \u2014OC(NR a )N(R a ) 2 , \u2014[N(R a )C(O)] n R a , \u2014(C(R a ) 2 ), \u2014OR a , \u2014N(R a )\u2014S(O) 2 R a , \u2014C(O)\u2014C 1-6 haloalkyl, \u2014S(O) 2 C 1-6 haloalkyl, \u2014OC(O)R a , \u2014O(C(R a ) 2 ) m \u2014OR a , \u2014S(C(R a ) 2 ) m \u2014OR a , \u2014N(R a )C 1-6 haloalkyl, \u2014P(O)(OR a ) 2 , \u2014N(R a )\u2014(C(R a ) 2 ) m \u2014OR a , \u2014[N(R a )C(O)] n OR a , \u2014[N(R a )C(O)] n N(R a ) 2 , \u2014[N(R a )C(NR a )] n N(R a ) 2  or \u2014N(R a )C(O)C 1-6 haloalkyl; or two R d , taken together with the atom or atoms to which they are attached, combine to form a 3-10 membered partially or fully saturated mono or bicyclic ring, optionally containing one or more heteroatoms and optionally substituted with one or more R a ; \n each R e  is independently for each occurrence C 1-6 alkyl, C 3-8 cycloalkyl, C 4-11  cycloalkylalkyl, C 6-10 aryl, C 7-16 arylalkyl, 2-6 membered heteroalkyl, 3-10 membered heteroalicyclyl, 4-11 membered heteroalicyclylalkyl, 5-15 membered heteroaryl or 6-16 membered heteroarylalkyl; \n p is 0, 1, 2, 3 or 4; \n each m is 1, 2 or 3; \n each n is 0, 1, 2 or 3; \n two R 2  groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered partially or fully saturated mono or bicyclic ring, optionally containing one or more heteroatoms and optionally substituted with one or more R a  and/or R b ; \n Z 1  and Z 2  are each independently CH, CR 2  or N; \n R 3  is H, optionally substituted C 1-6 alkyl or R 50 ; \n R 4  is H, optionally substituted C 1-6 alkyl or R 50 ; and \n R 5  is halo, \u2014CN, optionally substituted C 1-6 alkyl, alkynyl, hydroxy, optionally substituted C 1-6 alkoxy, nitro, \u2014N(R a ) 2 , \u2014C(O)N(R a ) 2 , \u2014CO 2 R a  or \u2014C(O)R a .

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.54839
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14023158', '15419660', '12692493', '15892224', '13685433']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8140395169195437
- 35 USC 102 Novelty (BERT): 0.5886855439558316
- Combined Prediction Score: 0.7915041196231725
- Mean Citation Score: 457.22748600000006
- Max Citation Score: 471.83752
- Similarity Product: 461.2097395754718

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test