PATENT CLAIM ANALYSIS

Application Number: 16035537
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "182000"]

Abstract:
This invention relates to methods of stimulating the activity of the human and animal enteric nervous system. The method comprises orally administering an aminoserol, such as squalamine, a naturally occurring aminosterol isolated from  Squalus acanthias,  or derivatives thereof, to a subject in need.

Claim (Index 17):
The method of  claim 1 , wherein:\n (a) the aminosterol is modified to include one or more of the following: (1) substitutions of the sulfate by a sulfonate, phosphate, carboxylate, or other anionic moiety chosen to circumvent metabolic removal of the sulfate moiety and oxidation of the cholesterol side chain; (2) replacement of a hydroxyl group by a non-metabolizable polar substituent, such as a fluorine atom, to prevent its metabolic oxidation or conjugation; and (3) substitution of various ring hydrogen atoms to prevent oxidative or reductive metabolism of the steroid ring system. or (b) the aminosterol is a derivative of squalamine or natural aminosterol modified through medical chemistry to improve bio-distribution, ease of administration, metabolic stability, or any combination thereof.

Metadata:
- Claim Count in Document: 52.0
- Percentile: 95.0
- Lexical Diversity: 1.19512
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15604489', '15604527', '14329627', '15604452', '12953083']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8388560990006053
- 35 USC 102 Novelty (BERT): 0.5825224051747706
- Combined Prediction Score: 0.8132227296180218
- Mean Citation Score: 445.97313
- Max Citation Score: 478.05997
- Similarity Product: 452.5216040224499

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test