PATENT CLAIM ANALYSIS

Application Number: 16042806
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "183000"]

Abstract:
Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed.

Claim (Index 1):
A compound of Formula I: or pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or stereoisomer thereof wherein: L 1  is straight or branched C 2 -C 4  alkyl optionally substituted with one or more substituents selected from the group consisting of OH, D, OR 10 , NH 2 , NHR 10 , and N(R 10 )(R 10\u2032 ), provided that no more than one oxygen or nitrogen is attached to any carbon; or L 1  is selected from the group consisting of \u2014CO\u2014C 1 -C 2 alkylenyl-, \u2014S(O) 2 \u2014, \u2014S(O) 2 NH\u2014, \u2014C(O)NH\u2014, \u2014C(O)NR 10 \u2014, \u2014C 1 -C 3 alkylenyl-C(O)\u2014C 1 -C 3 alkylenyl-, and a bond, wherein the C 1 -C 2  alkylenyl and C 1 -C 3  alkylenyl is optionally substituted with C 1 -C 4  alkyl;\n each R 10  and R 10\u2032  is independently selected from the group consisting of H; O\u2014C 1 -C 5  alkyl; C 1 -C 6  alkyl optionally substituted with one or more substituents selected from the group consisting of OH, O\u2014C 1 -C 5  alkyl, \u2014OP(O)(OH) 2 , OP(O)O 2 \u22122 M 2 , \u2014OC(O)alkyl, \u2014OC(O)Oalkyl, aryl, and heteroaryl; and \n cycloalkyl optionally substituted with one or more substituents selected from the group consisting of OH and O\u2014C 1 -C 5  alkyl; \n provided that no more than one oxygen is attached to any carbon of R 10  and R 10\u2032 ; \n M is a monovalent metal cation; \n or R 10  and R 10\u2032 , together with the nitrogen to which they are attached, may form a heterocycle; \n R 1  is aryl or heteroaryl, both of which optionally substituted with one or more substituents selected from the group consisting of OH, CN, halogen, \u2014O\u2014R 10 , \u2014OP(O)(OH) 2 , OP(O)O 2 \u22122 M 2 , \u2014SH, \u2014S\u2014R 10 , C 1 -C 5  alkyl, branched alkyl, \u2014C 1 -C 6 haloalkyl, NH 2 , NHR 10 , \u2014C 1 -C 6 hydroxyalkyl, N(R 10 )(NR 10\u2032 ), \u2014NHS(O) 2 R 10 , \u2014O\u2014 alkylaryl, \u2014O\u2014(CH 2 ) n \u2014C(O)-aryl, and NHCOR 10 ; M is a monovalent metal cation; or R 1  is cycloalkyl; X is selected from the group consisting of H, halogen, OH, O\u2014C 1 -C 6  alkyl, O-branched alkyl, C 1 -C 5  straight alkyl and C 1 -C 5  branched alkyl; Y and Y\u2032 are independently H, F, or methyl; L 2  is \u2014(CH 2 ) n \u2014 or \u2014(CHR 11 ) n \u2014, or a bond;\n each R 11  is independently selected from the group consisting of H, \u2014C 1 -C 5  alkylenyl-, \u2014C(O)\u2014C 1 -C 5 alkylenyl-, and -alkylenyl-CO-alkylenyl-; \n R 2  is C 3 -C 8 cycloalkyl; C 3 -C 8 heterocyclcyl, phenyl, naphthyl, heteroaryl, or bicyclic heteroaryl, each of which is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, C 1 -C 6 alkyl, OR 10 , CN, NH 2 , NHR 10 , N(R 10 )(R 10\u2032 ), SH, SR 10 , SOR 10 , SO 2 R 10 , SO 2 NHR 10 , SO 2 N(R 10 )(R 10\u2032 ), CONH 2 , CONRd, and CON(R 10 )(R 10\u2032 ); and n is 1, 2, or 3.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 95.0
- Lexical Diversity: 1.11111
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15360824', '14498462', '15506592', '15750128', '13413138']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8495178253624379
- 35 USC 102 Novelty (BERT): 0.62481275430762
- Combined Prediction Score: 0.8270473182569561
- Mean Citation Score: 441.344826
- Max Citation Score: 563.1285
- Similarity Product: 552.1756121154426

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test