PATENT CLAIM ANALYSIS

Application Number: 15768468
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "513000"]

Abstract:
The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase H 2 O 2  level in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce H 2 O 2  in comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.

Claim (Index 8):
The method according to  claim 7 , wherein said method comprises:\n a. measuring the H 2 O 2  level in a cancer cells sample of said subject; b. comparing the resulting level of step a. with a control value; c. measuring the GSH level in a cancer cells sample of said subject; and d. measuring the MDA-adducts and/or HNE-adducts level after an in vitro treatment with a compound of formula (I) in a cancer cells sample of said subject; wherein:\n a H 2 O 2  level of said cancer cells sample of said subject not higher than the control value, \n a GSH level of said cancer cells sample of said subject below 5 nmol for 25000 cells, and \n a MDA-adducts level above 75 ng per \u03bcg of total protein and/or a HNE-adducts level above 1 \u03bcg per \u03bcg of protein, \n indicates that the subject is likely to benefit from a treatment with a combination comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof and a compound able to increase the H 2 O 2  level in cancer cells of a subject.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 91.0
- Lexical Diversity: 1.79032
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13546713', '15495670', '15120476', '15778213', '12981233']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7323225238235016
- 35 USC 102 Novelty (BERT): 0.5016144585331885
- Combined Prediction Score: 0.7092517172944703
- Mean Citation Score: 191.747058
- Max Citation Score: 199.93008
- Similarity Product: 121.19675244701384

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test