PATENT CLAIM ANALYSIS

Application Number: 15749125
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["435", "288700"]

Abstract:
A method and a system for detection of presence or absence of analytes in fluids, the method comprising the steps of: a) contacting a fluid sample and a plurality of nanoparticles, the nanoparticles being functionalized with a selective ligand, the contact of the fluid sample with the nanoparticles being under conditions such that, the nanoparticles aggregate selectively on surface of their target analyte, forming a nanoparticle-analyte complex, the aggregation promoting the concentration of the nanoparticles on the surface of the target analyte; b) subjecting a fluid mixture of the fluid sample and the plurality of nanoparticles to SERS; c) measuring at least a SERS signal associated with the fluid mixture; d) spectrally analysing the at least one SERS signal of step c); e) recognizing at least one defined SERS spectrum of the nanoparticle-analyte complex, through a SERS signal enhanced by the at least one narrow inter-nanoparticle gap.

Claim (Index 1):
A method for detection\u2014of presence or absence of analytes in fluids\u2014, in an optical system ( 100 ), comprising the steps of:\n a) contacting in a mixing container ( 101 ), a fluid sample and a plurality of nanoparticles, wherein each of the nanoparticles comprises, a core unprotected and tagged with at least a molecular species with a defined SERS spectrum, the nanoparticles being functionalized with at least a selective ligand for a given receptor of a target analyte, the contact of the fluid sample with the nanoparticles being under conditions such that, when the fluid sample comprises at least an analyte, the nanoparticles aggregate selectively on surface of their target analyte forming a nanoparticle-analyte complex, the aggregation promoting the concentration of the nanoparticles on the surface of the target analyte and thus a plasmon coupling in between the nanoparticles through the generation of narrow inter-nanoparticle gaps; b) circulating the fluid mixture of the fluid sample and the plurality of nanoparticles through at least a passage ( 102 A,  102 B,  102 C) driven by the pump ( 103 ) following direction D.; c) subjecting a fluid mixture of the fluid sample and the plurality of nanoparticles to SERS passing said fluid mixture of fluid sample and nanoparticles through the detection section ( 108 ) where the emitter ( 104 ) issues an incident monochromatic light; d) measuring at least a SERS signal associated with the fluid mixture by the reader ( 105 ); e) spectrally analysing the at least one SERS signal of step c) by control means ( 106 ); f) recognizing at least one defined SERS spectrum of the nanoparticle-analyte complex, through a SERS signal enhanced by the at least one narrow inter-nanoparticle gap, when the fluid mixture comprises at least a nanoparticle-analyte complex with the narrow inter-nanoparticle gap.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 2.18421
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13217616', '12597742', '13564698', '15665095', '13872778']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.649704130061725
- 35 USC 102 Novelty (BERT): 0.5191135905606811
- Combined Prediction Score: 0.6366450761116207
- Mean Citation Score: 331.767876
- Max Citation Score: 335.6538
- Similarity Product: 243.8936906597972

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test