PATENT CLAIM ANALYSIS

Application Number: 16103375
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["514", "253130"]

Abstract:
The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmue disorders.

Claim (Index 21):
A combination therapy, comprising an antifolate and a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 0 , R 1  and R 2  are each independently selected from the group consisting of \u2014H, halogen, hydroxyl, nitro, nitrile, \u2014SOR 11 , \u2014S(O) 2 R 11 , \u2014S(O) 2 NR 10 R 12 , \u2014OR 11 , \u2014OC(O)R 12 , \u2014C(O)OR 12 , \u2014C(O)R 11 , \u2014C(O)NR 10 R 12 , \u2014NR 10 R 12 , \u2014N(R 12 )C(O)R 11 , \u2014NS(O) 2 R 12 , substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted haloalkyl, and substituted or unsubstituted haloalkoxy; provided that, at least one of R 0 , R 1  and R 2  is selected from the group consisting of substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl; R 3  is selected from the group consisting of \u2014H, halogen, hydroxyl, nitro, nitrile, \u2014SOR 11 , \u2014S(O) 2 R 11 , \u2014S(O) 2 NR 10 R 12 , \u2014OR 11 , \u2014OC(O)R 12 , \u2014C(O)OR 12 , \u2014C(O)R 11 , \u2014C(O)NR 10 R 12 , \u2014NR 10 R 12 , \u2014N(R 12 )C(O)R 11 , \u2014NS(O) 2 R 12 , substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted haloalkyl, and substituted or unsubstituted haloalkoxy; R 4  is selected from the group consisting of \u2014H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, and substituted or unsubstituted heteroarylalkyl; R 5 , R 6  and R 7  are each independently selected from the group consisting of \u2014H, \u2014C(O)R 11 , substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, and substituted or unsubstituted heteroarylalkyl; or R 5  is selected from any of the foregoing and R 6  and R 7  taken together with the nitrogen atom to which they are attached form a substituted or unsubstituted 3-6 membered ring; each occurrence of R 11  is independently selected from the group consisting of substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; and each occurrence of R 10  and R 12  is independently selected from the group consisting of \u2014H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 96.0
- Lexical Diversity: 1.30303
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15705200', '15552442', '14346359', '13891067', '13227130']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7820858943982323
- 35 USC 102 Novelty (BERT): 0.6862802583006349
- Combined Prediction Score: 0.7725053307884725
- Mean Citation Score: 448.057326
- Max Citation Score: 794.0231
- Similarity Product: 671.49802020697

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test