PATENT CLAIM ANALYSIS

Application Number: 16066402
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["549", "049000"]

Abstract:
The present invention relates to quinolin-2(1H)-one derivatives polymorph and its process thereof. Formula (I).

Claim (Index 21):
The process according to  claim 18 , a process for the preparation of Brexpiprazole compound of Formula I, which comprises: a. reacting compound of formula V with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the presence of an organic solvent selected from polar aprotic solvent, at a temperature of 30-60\u00b0 C. and having molar ratio of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to compound of formula V in the range of 0.5-2:1 to obtain a compound of formula II; b. condensing the compound of formula II with compound of formula VI, wherein X, Lg represents a halogen atom or a group which causes a substitution reaction the same as in halogen atom to yield a compound of formula III; c. condensing the compound of formula III with compound of formula IV or free base; to yield the compound of formula I; d. converting Brexpiprazole compound of formula I to Brexpiprazole hydrochloride; e. isolating Brexpiprazole hydrochloride Form H characterized by Powder X-Ray Diffraction, having the characteristic peaks at 12.5, 15.3, 18.2, 20.2\u00b0\u00b10.2\u00b0 20; and f. converting Brexpiprazole hydrochloride to Brexpiprazole. wherein steps d to f are optional, wherein the condensation of compound of formula II with formula VI and formula III with formula IV or its free base is carried out in the presence or absence of a base.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 94.0
- Lexical Diversity: 1.15789
- Patent Class: 549.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14373163', '15764616', '15541568', '13995786', '10553399']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7110159403489201
- 35 USC 102 Novelty (BERT): 0.5014875552369046
- Combined Prediction Score: 0.6900631018377186
- Mean Citation Score: 237.167226
- Max Citation Score: 244.66219
- Similarity Product: 190.98723111839053

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test