PATENT CLAIM ANALYSIS

Application Number: 16107491
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["536", "025300"]

Abstract:
Aspects of the present disclosure include methods for double coupling a nucleoside phosphoramidite during synthesis of an oligonucleotide. The method can include coupling a free hydroxyl group of a nucleoside residue with a first sample of a protected nucleoside phosphoramidite via an internucleoside P(III) linkage, followed by exposure to an oxidizing agent prior to a second coupling step with a second sample of the protected nucleoside phosphoramidite, and further exposure to an oxidizing agent. The method finds use in synthesizing an oligonucleotide on a solid phase support, such as a planar surface. The double coupling method can be utilized at one or more nucleotide positions during oligonucleotide synthesis thereby reducing single base deletion rates. Oligonucleotide containing compositions synthesized according to the disclosed methods are also provided.

Claim (Index 7):
The method of  claim 1 , wherein the protected nucleoside phosphoramidite is a nucleoside dimer.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 96.0
- Lexical Diversity: 1.6506
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15470779', '12118655', '13485592', '11899828', '11853662']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6579602749955096
- 35 USC 102 Novelty (BERT): 0.5368626912168549
- Combined Prediction Score: 0.6458505166176441
- Mean Citation Score: 292.5699400000001
- Max Citation Score: 383.75375
- Similarity Product: 370.56509233079856

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test