PATENT CLAIM ANALYSIS

Application Number: 15767676
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "275000"]

Abstract:
Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Claim (Index 2):
The compound according to  claim 1 , wherein Q 1  is selected from: wherein R 6a , R 6b , R 6c , R 6d , R 6e  are independently selected from hydrogen, halogen, hydroxyl, amino, nitro, cyano, isocyano, carboxyl, (CH 2 ) n OR 3d , (CH 2 ) n SR 3d , (CH 2 ) n S(O)R 3d  (CH 2 ) n SO 2 R 3d , (CH 2 ) n N(R 3c )R 3d , (CH 2 ) n C(O)R 3d , (CH 2 ) n N(R 3c )C(O)R 3d , (CH 2 ) n OC(O)R 3d , (CH 2 ) n C(O)OR 3d , (CH 2 ) n C(O)N(R 3c )R 3d , (CH 2 ) n N(R 3c )C(O)N(R 3c )R 3d , (CH 2 ) n SO 2 N(R 3c )R 3d , (CH 2 ) n N(R 3c )SO 2 R 3d , (CH 2 ) n N(R 3c )P(O)(R 3d ) 2 , (CH 2 ) n P(O)(N(R 3c R 3d )) 2 , and poly(ethylene oxide); R 3d  is in each case independently selected from hydrogen, substituted or unsubstituted C 1 -C 10  alkyl, substituted or unsubstituted C 3 -C 10  cycloalkyl, substituted or unsubstituted C 6 -C 12  aryl, and substituted or unsubstituted C 2 -C 10  heteroaryl; or wherein any two or more of R 3b , R 6a , R 6b , R 6c , R 6d , R 6e , R 3c  and R 3d  together form one or more rings; wherein A, B, and C are independently selected from a bond, O, \u2014C(R 6 ) 2 \u2014, \u2014C(R 6 ) 2 \u2014, \u2014C(R 6 ) 2 \u2014, \u2014C(R 6 ) 2 \u2014N(R 6 )\u2014, \u2014C(R 6 ) 2 \u2014O\u2014, NR 6 , S, SO, and SO 2 ; wherein A is O, NR 6 , S, SO, SO 2 , \u2014C(R 6 )\u2550C(R 6 )\u2014, or \u2014C(R 6 )\u2550N\u2014; and B and C are either N or CR 6 ; wherein B is O, NR 6 , S, SO, SO 2 , \u2014C(R 6 )\u2550C(R 6 )\u2014, or \u2014C(R 6 )\u2550N\u2014; and A and C are either N or CR 6 , C is O, NR 6 , S, SO, SO 2 , \u2014C(R 6 )\u2550C(R 6 )\u2014, or \u2014C(R 6 )\u2550N\u2014; A and B are either N or CR 6 , one R 6  group represents a bond to L 1 , and the remaining R 6  groups are independently selected from hydrogen, halogen, hydroxyl, amino, nitro, cyano, isocyano, carboxyl, (CH 2 ) n OR 3d , (CH 2 ) n S R 3d , (CH 2 ) n S(O) R 3d , (CH 2 ) n SO 2 R 3d , (CH 2 ) n N(R 3c )R 3d , (CH 2 ) n C(O)R 3d , (CH 2 ) n N(R 3c )C(O)R 3d , (CH 2 ) n OC(O)R 3d , (CH 2 ) n C(O)OR 3d , (CH 2 ) n C(O)N(R 3c )R 3d , (CH 2 ) n N(R 3c )C(O)N(R 3c )R 3d , (CH 2 ) n SO 2 N(R 3c )R 3d , (CH 2 ) n N(R 3c )SO 2 R 3d ; poly(ethylene oxide); or two adjacent R 6  groups form a double or triple bond, or two geminal R 6  groups together form a carbonyl; or any two R 6  groups together form a ring, or R 3b  and one or more R 6  groups together form a ring; and n in each case is independently selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10; wherein m is independently selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; and R 7  is in each case independently selected from hydrogen, halogen, hydroxyl, amino, nitro, cyano, isocyano, (CH 2 ) n OR 3d , (CH 2 ) n SR 3d , (CH 2 ) n S(O)R 3d , (CH 2 ) n SO 2 R 3d  (CH 2 ) n N(R 3c )R 3d , (CH 2 ) n C(O)R 3d , (CH 2 ) n N(R 3c )C(O)R 3d , (CH 2 ) n OC(O)R 3d , (CH 2 ) n C(O)OR 3d , (CH 2 ) n C(O)N(R 3c )R 3d , (CH 2 ) n N(R 3c )C(O)N(R 3c )R 3d , (CH 2 ) n SO 2 N(R 3c )R 3d , (CH 2 ) n N(R 3c )SO 2 R 3d , and poly(ethylene oxide); or two geminal R 7  groups together form a carbonyl; or R 7  groups on adjacent carbon atoms form a double or triple bond; or any two or more R 7  groups together form a ring, or R 3b  and one or more R 7  groups together for a ring.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 91.0
- Lexical Diversity: 1.43333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15501613', '15619671', '14204076', '14977508', '14633360']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7375142612701983
- 35 USC 102 Novelty (BERT): 0.542061575190958
- Combined Prediction Score: 0.7179689926622743
- Mean Citation Score: 311.770436
- Max Citation Score: 366.1146
- Similarity Product: 272.6737421548964

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test