PATENT CLAIM ANALYSIS

Application Number: 15781825
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["435", "239000"]

Abstract:
Described herein are processes for purifying infectious Zika virus particles and uses of protamine in such processes.

Claim (Index 4):
A process of purification of infectious Zika virus particles, comprising the steps of:\n a) providing a crude harvest (a) comprising Zika virus particles and impurities, wherein the impurities are generated from growing said Zika virus particles on a cell substrate; b) reducing impurities from said crude harvest (a) by precipitation with an agent comprising protamine, preferably a protamine salt, more preferably a protamine sulphate, even more preferably a recombinant protamine sulphate, to obtain a Zika virus preparation (b); c) further purifying said Zika virus preparation (b) by one or more size exclusion methods such as (i) a sucrose density gradient centrifugation, (ii) a solid-phase matrix packed in a column comprising a ligand-activated core and an inactive shell comprising pores, wherein the molecular weight cut off of the pores excludes the Zika virus particles from entering the ligand-activated core, and wherein a molecule smaller than the molecular weight cutoff of the pores can enter the ligand-activated core and collecting the virus particles, and/or (iii) size exclusion chromatography to obtain a virus preparation (c) comprising the infectious Zika virus particles, wherein the residual host cell DNA of the virus preparation (c) is less than 100 ng/mL and the residual host cell protein and the residual aggregates of infectious virus particles of the final virus preparation (c) is less than 1 \u03bcg/mL.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 94.0
- Lexical Diversity: 1.05882
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15781959', '16062245', '16063007', '15212804', '15897488']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6679822533702962
- 35 USC 102 Novelty (BERT): 0.6243421029332986
- Combined Prediction Score: 0.6636182383265964
- Mean Citation Score: 445.52125
- Max Citation Score: 651.8094
- Similarity Product: 515.891581726098

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test