PATENT CLAIM ANALYSIS

Application Number: 15894546
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["435", "006100"]

Abstract:
The invention relates to improved methods, devices, and kits for identifying and implementing an appropriate treatment regimen for subjects suffering from hypertension.

Claim (Index 66):
A method for treating cardiovascular hypertension in a patient comprising administering to the patient as a first line therapy a first line drug selected from a diuretic, a vasodilator, a beta blocker, a diuretic or an ACE inhibitor wherein the selection and administration of the first line drug is made by obtaining a sample of fluid or tissue from the patient, obtaining DNA analyses of the sample, the analyses providing DNA sequences relating to the fourteen following nucleic acid sequences:\n 1. a WNK1 nucleic acid with a cytosine at the variable position of rs1159744; 2. a WNK1 nucleic acid with a cytosine at the variable position of rs2107614; 3. an ADD1 nucleic acid with a thymine at the variable position of rs4961; 4. a SLC12A3 nucleic acid with a thymine at the variable position of rs1529927; 5. a CYP2D6 nucleic acid with an adenine at the variable position of Rs3892097; 6. an ADRB1 nucleic acid with a cytosine at the variable position of rs1801253; 7. an ADRB1 nucleic acid with an adenine at the variable position of rs1801252; 8. a renin nucleic acid with a cytosine at the variable position of rs12750834; 9. an AGT1R nucleic acid with a cytosine at the variable position of rs5186; 10. an ACE nucleic acid with a deletion in rs1799752, 11. an AGT nucleic acid with a cytosine at the variable position of rs699; 12. a SCNN1A nucleic acid with an adenine at the variable position of rs2228576; 13. an ADRB2 nucleic acid with a guanine at the variable position of rs1042714; and 14. an ADRB2 nucleic acid with a guanine at the variable position of rs1042713; And administering the first line drug to the patient according to one of the procedures a)-f): a) Administering a thiazide or thiazide-like diuretic to the patient as a first line therapy, without a beta blocker and without a vasodilator, if the sample DNA presents a WNK1 nucleic acid with a cytosine at the variable position of rs1159744 or rs2107614; b) Administering a thiazide or a thiazide-like diuretic to the patient as a first line therapy, without a beta blocker and without a vasodilator, if the sample DNA presents an ADD1 nucleic acid with a thymine at the variable position of rs4961, or if the test sample comprises a SLC12A3 nucleic acid with a thymine at the variable position of rs1529927; c) Administering a beta blocker to the patent as a first line therapy without a diuretic and without a thiazide or thiazide-like diuretic if the sample DNA presents:\n 1. a CYP2D6 nucleic acid with an adenine at the variable position of Rs3892097; \n 2. an ADRB1 nucleic acid with a cytosine at the variable position of rs1801253; \n 3. an ADRB1 nucleic acid with an adenine at the variable position of rs1801252; \n 4. an ADRB2 nucleic acid with a guanine at the variable position of rs1042714; or \n 5. an ADRB2 nucleic acid with a guanine at the variable position of rs1042713; \n And the sample DNA does not present \n 1. a WNK1 nucleic acid with a cytosine at the variable position of rs1159744; \n 2. a WNK1 nucleic acid with a cytosine at the variable position of rs2107614; \n 3. an ADD1 nucleic acid with a thymine at the variable position of rs4961; or \n 4. a SLC12A3 nucleic acid with a thymine at the variable position of rs1529927; \n d) Administering an angiotensin II receptor blocker to the patient as a first line therapy, without a diuretic, without a thiazide, and without a beta-blocker, if the sample DNA presents:\n 1. a renin nucleic acid with a cytosine at the variable position of rs12750834; or \n 2. an AGT1R nucleic acid with a cytosine at the variable position of rs5186; \n And the sample DNA does not present \n 1. a WNK1 nucleic acid with a cytosine at the variable position of rs1159744; \n 2. a WNK1 nucleic acid with a cytosine at the variable position of rs2107614; \n 3. an ADD1 nucleic acid with a thymine at the variable position of rs4961; or \n 4. a SLC12A3 nucleic acid with a thymine at the variable position of rs1529927; \n e) Administering an ACE inhibitor without an angiotensin II receptor blocker to the patient as a first line therapy, without a diuretic, without a thiazide, and without a beta-blocker, if the sample DNA presents comprises:\n 1. an ACE nucleic acid with a deletion in rs1799752; or \n 2. an AGT nucleic acid with a cytosine at the variable position of rs699; \n And the test sample DNA does not present \n 1. a WNK1 nucleic acid with a cytosine at the variable position of rs1159744; \n 2. a WNK1 nucleic acid with a cytosine at the variable position of rs2107614; \n 3. an ADD1 nucleic acid with a thymine at the variable position of rs4961; or \n 4. a SLC12A3 nucleic acid with a thymine at the variable position of rs1529927; \n f) Administering an amiloride to the patient as a first line therapy without an ACE inhibitor, without an angiotensin II receptor blocker, without a diuretic, without a thiazide, and without a beta-blocker, if the sample DNA presents a SCNN1A nucleic acid with an adenine at the variable position of rs2228576;\n And the sample DNA does not present \n 1. a WNK1 nucleic acid with a cytosine at the variable position of rs1159744; \n 2. a WNK1 nucleic acid with a cytosine at the variable position of rs2107614; \n 3. an ADD1 nucleic acid with a thymine at the variable position of rs4961; or \n 4. a SLC12A3 nucleic acid with a thymine at the variable position of rs1529927.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 88.0
- Lexical Diversity: 1.13636
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15314641', '15037030', '10077870', '15813469', '13799682']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5094154102682708
- 35 USC 102 Novelty (BERT): 0.6139204157308783
- Combined Prediction Score: 0.5198659108145315
- Mean Citation Score: 302.041664
- Max Citation Score: 652.6511
- Similarity Product: 458.7749059780538

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test