PATENT CLAIM ANALYSIS

Application Number: 16088695
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["514", "063000"]

Abstract:
The present invention discloses a silicon incorporated quinoline of formula (I) wherein, X, Y, A, R 1  and R 2  are as described. The present invention further discloses a process for the preparation of silicon incorporated quinolines of formula I; a pharmaceutical composition comprising silicon incorporated quinolines of formula (I) or pharmaceutically acceptable salt thereof. The present invention also discloses a method for treating diseases caused by  Plasmodium falciparum  or other  coccidian  parasites using the silicon incorporated quinolines of formula I or pharmaceutically acceptable salt thereof.

Claim (Index 3):
A process for the preparation of silicon incorporated quinoline of formula (I), said process comprises the steps of:\n a) adding an amino compound and a base to a solution of 4-(bromomethyl)benzonitrile in a solvent followed by stirring at a temperature in the range of 25 to 30\u00b0 C. for a period in the range of 10 to 12 h to obtain corresponding cyano compound 1 or compound 4; b) refluxing a reaction mixture of a Grignard reagent and a solution of compound 1 or 4 obtained in step (a) in a solvent at a temperature in the range of 100 to 110\u00b0 C. for a period in the range of 3 to 4 hrs followed by cooling to 0\u00b0 C. and acidifying with an acid and further refluxing at a temperature in the range of 100 to 110\u00b0 C. for a period in the range of 1 to 2 h to obtain corresponding keto compound 2 or compound 5; c) adding a solvent followed by a base to a reaction mixture of compound 2 or compound 5 obtained in step (b) and 5-fluoroisatin followed by heating the reaction mixture at a temperature in the range of 110 to 120\u00b0 C. for a period in the range of 10 to 20 min in a microwave reactor to obtain corresponding acid compound 3 or compound 6; d) adding HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate), DIPEA (N,N-Diisopropylethylamine) and a nitrogen containing heterocyclic compound to a solution of compound 3 or compound 6 obtained in step (c) in a solvent followed by stirring at a temperature in the range of 25 to 30\u00b0 C. for a period in the range of 10 to 12 h to obtain the silicon incorporated quinoline of formula I.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 97.0
- Lexical Diversity: 1.84906
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14350766', '15752896', '14895710', '11477745', '12142846']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8052743358066379
- 35 USC 102 Novelty (BERT): 0.5351107349215934
- Combined Prediction Score: 0.7782579757181335
- Mean Citation Score: 315.892494
- Max Citation Score: 361.45117
- Similarity Product: 232.1026101652062

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test