PATENT CLAIM ANALYSIS

Application Number: 15762363
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["800", "017000"]

Abstract:
The present invention relates to genetically-edited swine comprising an introgressed heterologous nucleic acid sequence in the RELA gene. In particular it relates to genetically-edited swine comprising an introgressed warthog allele in the RALA gene of domestic pigs. The invention also related to methods of producing such swine, and cells derived from swine having such introgressed sequences.

Claim (Index 24):
A method of producing a genetically-edited swine having an introgressed heterologous nucleic acid sequence in the RELA gene, the method comprising the steps of:\n providing a swine zygote; introducing into said zygote a site-specific nuclease, the nuclease being adapted to target a desired genomic sequence in the RELA gene to be edited, and to introduce a double stranded break; introducing a template nucleic acid comprising the heterologous nucleic acid sequence to be introgressed into the RELA gene, the heterologous sequence being flanked by sequences homologous to genomic RELA sequences; incubating said zygote under suitable conditions to permit cutting of the genome by the site-specific nuclease and introgression of the heterologous nucleic acid sequence into the RELA gene by homology directed repair; and generating an animal from said zygote.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 90.0
- Lexical Diversity: 1.5
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14427776', '14263446', '14907069', '15128595', '13836860']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6042274588273924
- 35 USC 102 Novelty (BERT): 0.5469691926621155
- Combined Prediction Score: 0.5985016322108647
- Mean Citation Score: 323.4126320000001
- Max Citation Score: 444.29813
- Similarity Product: 342.7072026422691

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test