PATENT CLAIM ANALYSIS

Application Number: 16000969
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["544", "277000"]

Abstract:
Provided herein are Aminopurine compounds of Formula I: or pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein R 1 , R 2 , and R 3  are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing animal and human protozoal infections.

Claim (Index 21):
The method of  claim 1 , wherein the compound is:\n 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-(1-methylcyclobutyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-tert-pentyl-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-(1-methylcyclopentyl)-9H-purine-2,8-diamine, N8-(3-chlorophenyl)-9-((1s,4s)-4-((dimethylamino)methyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-tert-butyl-N8-(pyridin-2-yl)-9H-purine-2,8-diamine, 9-((1r,4r)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-N8-(pyridin-2-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(2,3-difluorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, (1s,4s)-4-(8-(3-chlorophenylamino)-2-(1-methylcyclopentylamino)-9H-purin-9-yl)cyclohexanol, N-(((1s,4s)-4-(8-(3-chlorophenylamino)-2-(4-methyltetrahydro-2H-pyran-4-ylamino)-9H-purin-9-yl)cyclohexyl)methyl)acetamide, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(1-methylcyclopentyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-tert-pentyl-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, methyl ((1s,4s)-4-(8-(3-chlorophenylamino)-2-(4-methyltetrahydro-2H-pyran-4-ylamino)-9H-purin-9-yl)cyclohexyl)methylcarbamate, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-tert-butyl-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(1-methylcyclopentyl)-N8-(4-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1r,4r)-4-(aminomethyl)cyclohexyl)-N2-tert-butyl-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1 r,4r)-4-(aminomethyl)cyclohexyl)-N2-tert-butyl-N8-p-tolyl-9H-purine-2,8-diamine, ((1s,4 s)-4-(8-(3-chlorophenylamino)-2-(4-methyltetrahydro-2H-pyran-4-ylamino)-9H-purin-9-yl)cyclohexyl)methanol, 9-((1R, 3 S)-3-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, N8-(3-chlorophenyl)-9-((1s,4s)-4-((methylamino)methyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-tert-butyl-N8-(4-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-tert-pentyl-N8-(4-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, (1s,4s)-4-(2-(4-methyltetrahydro-2H-pyran-4-ylamino)-8-(3-(trifluoromethyl)phenylamino)-9H-purin-9-yl)cyclohexanecarbonitrile, N-((1s,4s)-4-(8-(3-chlorophenylamino)-2-(4-methyltetrahydro-2H-pyran-4-ylamino)-9H-purin-9-yl)cyclohexyl)acetamide, ((1r,4r)-4-(8-(3-chlorophenylamino)-2-(4-methyltetrahydro-2H-pyran-4-ylamino)-9H-purin-9-yl)cyclohexyl)methanol, 9-((1s,4s)-4-aminocyclohexyl)-N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-aminocyclohexyl)-N2-tert-butyl-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1r,4r)-4-aminocyclohexyl)-N2-tert-butyl-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-N8-(4-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-(4-(aminomethyl)phenyl)-N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(5-chloropyridin-3-yl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-N8-(2-(trifluoromethyl)pyridin-4-yl)-9H-purine-2,8-diamine, 9-(3-aminocyclobutyl)-N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-N8-(3-(trifluoromethoxy)phenyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-N8-(4-(trifluoromethoxy)phenyl)-9H-purine-2,8-diamine, 9-(3-aminocyclobutyl)-N2-tert-butyl-N8-(3,4-dichlorophenyl)-9H-purine-2,8-diamine, N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-((1s,4s)-4-(piperidin-1-ylmethyl)cyclohexyl)-9H-purine-2,8-diamine, N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-((1s,4s)-4-(morpholinomethyl)cyclohexyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(2-fluoro-5-(trifluoromethyl)phenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3,5-dichlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3,5-difluorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-N8-(6-(trifluoromethyl)pyridin-2-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(2-fluoro-3-(trifluoromethyl)phenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chloro-5-fluorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-tert-butyl-N8-(3,5-dichlorophenyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chloro-2-fluorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(5-chloro-2-fluorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-(1-methylcyclopropyl)-9H-purine-2,8-diamine, 3-(9-((1r,4r)-4-aminocyclohexyl)-2-(tert-butylamino)-9H-purin-8-ylamino)benzonitrile, 9-((1r,4r)-4-aminocyclohexyl)-N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 2-(9-((1s,4s)-4-(aminomethyl)cyclohexyl)-8-(3-chlorophenylamino)-9H-purin-2-ylamino)-2-methylpropan-1-ol, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-(1-methylcyclobutyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-((dimethylamino)methyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N2-(1-methylcyclobutyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-((methylamino)methyl)cyclohexyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-(4-aminocyclohexyl)-N8-(2-fluoro-5-(trifluoromethyl)phenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-chloro-2-fluorophenyl)-9-((1s,4s)-4-((dimethylamino)methyl)cyclohexyl)-9H-purine-2,8-diamine, or 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(2-fluoro-5-(trifluoromethyl)phenyl)-N2-(1-methylcyclobutyl)-9H-purine-2,8-diamine, or a pharmaceutically acceptable salt, tautomer, isotopologue, or stereoisomer thereof.

Metadata:
- Claim Count in Document: 95.0
- Percentile: 94.0
- Lexical Diversity: 1.43902
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15611061', '15611108', '16000968', '15335619', '14874513']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7960403559188703
- 35 USC 102 Novelty (BERT): 0.6769839249458304
- Combined Prediction Score: 0.7841347128215663
- Mean Citation Score: 476.6811080000001
- Max Citation Score: 714.4842
- Similarity Product: 646.4095141770242

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test