PATENT CLAIM ANALYSIS

Application Number: 15941644
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["424", "408000"]

Abstract:
Disclosed herein are sustained release Liothyronine oral capsule formulations, methods of making the formulations and use to treat hypothyroidism, a thyroid deficient disease state, or thyroid dysfunction.

Claim (Index 1):
A sustained release oral capsule formulation, comprising:\n a capsule fill comprising liothyronine or a pharmaceutically acceptable salt thereof, a hydroxypropyl methylcellulose, and a filler; the liothyronine or a pharmaceutically acceptable salt thereof is present in an amount equivalent to about 0.1 to about 25 micrograms of liothyronine; about 25 to about 95% wt of a hydroxypropyl methylcellulose based on the total weight of the hydroxypropyl methylcellulose and filler, wherein the hydroxypropyl methylcellulose has 19-30% methoxyl content, 7-12% hydroxypropoxyl content, and 3000-120000 cP apparent viscosity as a 2% solution in water at 20\u00b0 C.; and about 5 to about 75% wt of a filler based on the total weight of the hydroxypropyl methylcellose and filler, wherein the filler is lactose or microcrystalline cellulose; wherein the capsule formulation exhibits a Zero order or Higuchi release kinetic pattern.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.14815
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15912438', '13498751', '12097163', '14776386', '14062759']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.717751928560759
- 35 USC 102 Novelty (BERT): 0.497718369371368
- Combined Prediction Score: 0.6957485726418199
- Mean Citation Score: 224.737068
- Max Citation Score: 237.49814
- Similarity Product: 166.72265194597722

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test