PATENT CLAIM ANALYSIS

Application Number: 15945429
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "210180"]

Abstract:
The invention relates to a compound of formula (I) wherein R 1  and R 2  are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Claim (Index 22):
The compound according to  claim 1  which compound is selected from the group consisting of;\n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-1,3-dimethyl-1H-pyrazole-5-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxamide; \n (S)-3-tert-butyl-N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-1-methyl-3-phenyl-1H-pyrazole-5-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-2-(4-chlorophenyl)-5-methyloxazole-4-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-2-(4-fluorophenyl)-2H-1,2,3-triazole-4-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-3-(2-chlorophenyl)-1H-pyrazole-5-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide, \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-3-phenylisoxazole-5-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-5-(3-fluorophenyl)-1,2,4-oxadiazole-3-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-2-phenyl-2H-1,2,3-triazole-4-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-3-(3-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxamide; \n (S)\u2014N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-5-(3-chlorophenyl)-1,2,4-oxadiazole-3-carboxamide; \n (2S)-2-[[1-[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]-2,2,2-trifluoroethyl]amino]-3-[3-chloro-4-(trifluoromethoxy)phenyl]-N-(1-cyanocyclopropyl)propanamide; \n (2S)-2-(1-(5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl)-2,2,2-trifluoroethylamino)-3-(3-chloro-4-(trifluoromethoxy)phenyl)-N-(1-cyanocyclopropyl)propanamide; \n (2S)-3-(3-chloro-4-(trifluoromethoxy)phenyl)-N-(1-cyanocyclopropyl)-2-(2,2,2-trifluoro-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethylamino)propanamide; \n (2S)-3-(3-chloro-4-(trifluoromethoxy)phenyl)-N-(1-cyanocyclopropyl)-2-((2,2,2-trifluoro-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl)amino)propanamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(4-methylsulfanylphenyl)triazole-4-carboxamide; \n 2-(4-chlorophenyl)-N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]triazole-4-carboxamide; \n N-[(2S)-3-(3-chlorophenyl)-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-pyridin-3-yltriazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-1-oxo-3-phenylpropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(cyclopropylmethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(6-fluoropyridin-3-yl)triazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-4-methyl-1-oxopentan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-propan-2-yltriazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-methyltriazole-4-carboxamide; \n 2-(4-bromophenyl)-N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(2-methoxyethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n 2-tert-butyl-N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(cyclobutylmethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-1-oxo-3-pyridin-4-ylpropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-3-(4-chlorophenyl)-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-pyridin-4-yltriazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-cyclobutyltriazole-4-carboxamide; \n N-[(2S)-3-(3-chloro-4-cyanophenyl)-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(oxan-4-yl)triazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl]-2-(oxan-4-yl)triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-cyclohexyltriazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-3-(2-cyanophenyl)-1-oxopropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-1-oxo-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-3-(2-chlorophenyl)-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl]-2-(3,3-difluorocyclobutyl)triazole-4-carboxamide; \n tert-butyl 6-[4-[[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]carbamoyl]triazol-2-yl]-2-azaspiro[3.3]heptane-2-carboxylate; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl]-2-cyclobutyltriazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(3,3-difluorocyclobutyl)triazole-4-carboxamide; \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-3-(3,4-dichlorophenyl)-1-oxopropan-2-yl]-2-(oxetan-3-yl)triazole-4-carboxamide; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-(oxetan-3-yl)triazole-4-carboxamide; \n 2-(2-azaspiro[3.3]heptan-6-yl)-N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]triazole-4-carboxamide; \n tert-butyl 3-[4-[[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]carbamoyl]triazol-2-yl]pyrrolidine-1-carboxylate; \n N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-pyrrolidin-3-yltriazole-4-carboxamide; \n 2-(azetidin-3-yl)-N-[(2S)-3-[3-chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]triazole-4-carboxamide; and \n N-[(2S)-1-[(1-cyanocyclopropyl)amino]-1-oxo-3-pyridin-2-ylpropan-2-yl]-2-(4-fluorophenyl)triazole-4-carboxamide; or \n a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 91.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12761427', '15567668', '13148296', '15320155', '13049941']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8122659156184678
- 35 USC 102 Novelty (BERT): 0.5108574680359318
- Combined Prediction Score: 0.7821250708602143
- Mean Citation Score: 279.468204
- Max Citation Score: 312.96332
- Similarity Product: 267.89945793235296

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test