PATENT CLAIM ANALYSIS

Application Number: 15960765
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["435", "194000"]

Abstract:
Kits for stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's Giα protein serine phosphorylation profile and/or the degree of imbalance in G-protein coupled receptor responses to Giα and Gsα protein stimulation. In some embodiments, the methods involve detecting or determining the level of serine phosphorylated Giα1 and/or Giα3 proteins in the cell sample, and/or determining a ratio between the response to Giα protein stimulation and the response to Gsα protein stimulation from a biological sample from the subject. Kits for predicting the risk of an AIS subject for developing a severe scoliosis, for predicting the subject's responsiveness to bracing treatment, and for identifying therapeutically useful compounds are also provided.

Claim (Index 5):
The kit of  claim 1 , wherein said ligand for stimulating the activity of Gi\u03b1 proteins is melatonin, Apelin, PB554, LPA, somatostatin, or UK14304.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 91.0
- Lexical Diversity: 1.78481
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14898904', '14917757', '14804225', '12232141', '13726416']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6103919890035349
- 35 USC 102 Novelty (BERT): 0.5406211689916365
- Combined Prediction Score: 0.603414907002345
- Mean Citation Score: 314.788052
- Max Citation Score: 374.7862
- Similarity Product: 322.1776802497864

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test