PATENT CLAIM ANALYSIS

Application Number: 16075932
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "394000"]

Abstract:
The present invention is related to diagnostic, treatment and compound screening methods related to dry age-related macular degeneration (dry AM D). In select embodiments, the methods comprise determining expression or activity levels of NAD-dependent deacetylase sirtuin-1 (SI RT-1), AM P-activated protein kinase (AM PK), poly(adenosine diphosphate ribose) poly-merase-2 (PARP2), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-Iα) and/or mRNA levels of RAC-gamma serine/threonine-protein kinase (AKT3). In general, higher levels of PARP2, lower levels of PGC-Iα or AKT3 and/or higher acetylation levels of PGC-Iα in the samples are indicative that the subject or cells from which the samples are obtained are susceptible or are suffering from dry AMD.

Claim (Index 16):
A method of monitoring the progression of dry age-related macular degeneration (dry AMD) in a subject, the method comprising\n a) analyzing at least two samples from the subject with each sample taken at different time points to determine expression or activity levels Poly (Adenosine diphosphate-Ribose) Polymerase 2 (PARP2), and b) comparing the expression or activity levels of the subject's PARP2 over time to determine if expression or activity levels of PARP2 are changing over time, wherein an increase in the subject's expression or activity levels of PARP2 over time is indicative that the subject's risk of suffering from dry AMD is increasing over time.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 96.0
- Lexical Diversity: 1.71053
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12583073', '15485997', '14746221', '10773446', '11660986']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7601106176648282
- 35 USC 102 Novelty (BERT): 0.5189183858945964
- Combined Prediction Score: 0.7359913944878052
- Mean Citation Score: 258.177182
- Max Citation Score: 271.42883
- Similarity Product: 150.1626815098989

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test