PATENT CLAIM ANALYSIS

Application Number: 16050069
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "456000"]

Abstract:
The invention encompasses compositions and methods for effectively treating and/or preventing the development and/or progression of osteoarthritis and rheumatoid arthritis and for promoting overall joint health. This is accomplished by totally addressing the key multiple biochemical processes and mechanisms that lead to such disorders. The invention includes compositions comprising a combination of natural agents that safely and effectively suppress, regulate or interfere with the various biochemical processes and mechanisms that increase the risk for or lead to the development and/or progression of OA and RA. The present compositions are holistically formulated to be effective in preventing/arresting loss of and/or damage to the articular cartilage (AC) by suppressing (a) extracellular matrix (ECM) degradation, (b) chondrocyte apoptosis, and (c) inflammation of synovium through modulation of mechanisms that involve transcription factors, growth factors, kinases, antiapoptotic/apoptotic factors and deacetylases. The active agents used herein are natural materials, in particular phytonutrients (or phytochemicals), minerals and/or vitamins.

Claim (Index 10):
A method of preventing, treating and alleviating the symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA) and of promoting overall joint health in human and other mammalian subjects having or at risk of developing OA, RA and associated joint disorders comprising administering to said subjects a composition comprising a combination of active agents that effectively suppress, regulate or interfere with biochemical processes and mechanisms that lead to OA and RA, wherein the combination comprises (a) at least one agent that inhibits and/or suppresses expression and/or activity of one or more of inflammatory mediators including interleukins IL-1\u03b1, IL-1\u03b2, IL-6, NF-\u03baB, TNF-\u03b1, matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), and nitric oxide (NO); (b) at least one agent that inhibits the activity of pro-oxidants including reactive nitrogen species (RNS) and reactive oxygen species (ROS) and/or upregulates expression and/or activity of antioxidants including glutathione (GS), superoxide dismutase (SOD) and catalase; (c) at least one agent that induces the expression of and/or activates one or more of AMPK (adenosine monophosphate-activated protein kinase), SIRT1 (sirtuin1), HIF-1\u03b1 (hypoxia inducible factor 1 alpha), SOX9 (SRY-related protein 9), BMP-7 (bone morphogenetic protein 7), and ERK 1/2 (extracellular regulated kinase isoforms 1 and 2); (d) at least one agent capable of modulating expression and/or activity of one or more of Runx2 (Runt-related transcription factor 2 also known as core-binding factor subunit alpha-1), P38-MAPK (mitogen-activated protein kinase), HIF-2\u03b1 (hypoxia inducible factor 2 alpha), and AP-1 (Activator protein-1); (e) at least one agent capable of modulating expression and/or activity of one or more of VEGF (vascular endothelial growth factor) and FGF (fibroblast growth factor); (f) at least one agent capable of modulating expression and/or activity of one or more of NMDAR (N-methyl-D-aspartic acid receptor), mTOR (mammalian target for rapamycin) and Wnt/\u03b2-catenin signaling pathway; and (g) at least one agent capable of inducing expression of and/or activating antiapoptotic proteins (including Bcl-2 and beclin) and/or suppressing proapoptotic proteins (including Bax, Bcl-2-associated X protein); wherein the composition comprises three or more phytonutrients as active agents and wherein the composition is safe and effective for preventing, treating and alleviating the symptoms of OA, RA and associated joint disorders.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 95.0
- Lexical Diversity: 1.74257
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12373584', '12048613', '15265009', '15308725', '12861152']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7487591098620464
- 35 USC 102 Novelty (BERT): 0.4889514252414476
- Combined Prediction Score: 0.7227783413999865
- Mean Citation Score: 208.79038600000004
- Max Citation Score: 223.04387000000003
- Similarity Product: 166.99031823029998

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test