PATENT CLAIM ANALYSIS

Application Number: 15766736
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "265100"]

Abstract:
Provided are methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.

Claim (Index 71):
A method of preparing a compound of Formula (I) or Compound 1, or a pharmaceutically acceptable salt thereof, comprising\n reacting a compound of Formula (XVII) with acryloyl chloride to form the compound of Formula (I); wherein X 1  is O, NH, or S; R 1  and R 2  are each independently hydrogen, halo, C 1-6 alkyl, or C 1-6 haloalkyl; R 3  is halo, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, cyano, or nitro; n is 0, 1, 2, 3, or 4; R 4  is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, or \u2014NR 22 R 23 ; wherein the alkyl and cycloalkyl are unsubstituted or substituted with hydroxyl or amino; and R 22  and R 23  are each independently hydrogen or C 1-6 alkyl; or R 22  and R 23  taken together with the nitrogen to which they are attached form a 3- to 10-membered heterocycloalkyl ring; R 5  is hydrogen or C 1-6 alkyl; R 6  and R 7  are each independently hydrogen, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkoxy, C 1-6 haloalkoxy, hydroxyl, cyano, or nitro; R 8  is hydrogen, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, hydroxyl, cyano, or nitro; R 11  and R 12  are each independently hydrogen or C 1-6 alkyl; Q is CR 9  or N; where R 9  is hydrogen, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, hydroxyl, cyano, or nitro; \u2014NR 18 R 19  is: where R 10  is selected from hydrogen and C 1-6  alkyl; R 15  is unsubstituted methyl, or is C 2-4 alkyl unsubstituted or substituted with hydroxy, methoxy, or halo; and m is 1 or 2; or (b) R 19  and R 9  are taken together with the atoms to which they are attached to form a 5- or 6-membered heteroaryl ring optionally substituted with C 1-6 alkyl, wherein the alkyl is unsubstituted or substituted with amino, hydroxyl, halo, or an N-linked heterocycloalkyl; and R 18  is hydrogen or C 1-6 alkyl, where the alkyl is unsubstituted or substituted with amino, or R 18  is absent to satisfy valency of the heteroaryl ring.

Metadata:
- Claim Count in Document: 166.0
- Percentile: 91.0
- Lexical Diversity: 1.66667
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14420341', '15708024', '14712794', '15509569', '13843554']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6932146688877362
- 35 USC 102 Novelty (BERT): 0.5312959349632731
- Combined Prediction Score: 0.6770227954952899
- Mean Citation Score: 339.1113220000001
- Max Citation Score: 346.8182700000001
- Similarity Product: 309.9307551601321

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test