PATENT CLAIM ANALYSIS

Application Number: 16158074
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["435", "007800"]

Abstract:
Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy), e.g., amyotrophic lateral sclerosis (ALS), etc.

Claim (Index 8):
The method of  claim 1 , wherein occluded amino acids are associated with a protein in a bound state.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 97.0
- Lexical Diversity: 2.24615
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13638237', '13056877', '12030024', '14482899', '12154664']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6230764103378026
- 35 USC 102 Novelty (BERT): 0.499170930904087
- Combined Prediction Score: 0.610685862394431
- Mean Citation Score: 212.087584
- Max Citation Score: 243.99301
- Similarity Product: 169.60027071046414

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test