PATENT CLAIM ANALYSIS

Application Number: 15885591
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["424", "078300"]

Abstract:
Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.

Claim (Index 1):
A composition comprising nanoparticulate constructs wherein said nanoparticulate constructs comprise:\n a) an amphiphilic stabilizer, and b) a conjugate of the formula\n (active\u2212linker) n \u2212hydrophobic moiety \u2003\u2003(1) \n wherein n is an integer of 1-100; \u201cactive\u201d refers to a compound that has a desired activity; \u201clinker\u201d is a divalent residue of an organic molecule, which divalent residue is selectively cleavable by reduction or hydrolysis upon exposure to a predefined stimulus to, thereby, control the release of said active from the hydrophobic moiety and the nanoparticulate construct, the cleavage being either within the divalent residue, at the bond that couples the linker to the active, or at the bond that couples the linker to the hydrophobic moiety; and \u201chydrophobic moiety\u201d refers to the residue of an organic molecule that is insoluble in aqueous solution; and i) wherein the one or more active is a therapeutic agent or a diagnostic agent; or ii) wherein the one or more active is a compound other than a pharmaceutical agent and other than a diagnostic agent; wherein the hydrophobic moiety is a polymer having a molecular weight between 800 and 200,000 g/mole or is a natural product selected from the group consisting of hydrophobic vitamins, carotenoids, retinols, cholecalciferol, calcitriol, hydroxycholecalciferol, ergocalciferol, \u03b1-tocopherol, \u03b1-tocopherol acetate, \u03b1-tocopherol nicotinate, and estradiol, and the amphiphilic stabilizer is a copolymer having a hydrophilic region and a hydrophobic region, which copolymer is a graft, block or random amphiphilic copolymer and has a molecular weight between1,000 g/mole and 50,000 g/mole.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.14286
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10101093', '13820351', '10984679', '10416980', '14575517']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7039209757245971
- 35 USC 102 Novelty (BERT): 0.4905683959334359
- Combined Prediction Score: 0.682585717745481
- Mean Citation Score: 227.12185800000003
- Max Citation Score: 229.39345
- Similarity Product: 172.87541628825662

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test