PATENT CLAIM ANALYSIS

Application Number: 15926936
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["560", "155000"]

Abstract:
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

Claim (Index 1):
A cationic lipid of Formula A: wherein: R 1  and R 2  are independently selected from H, (C 1 -C 6 )alkyl, heterocyclyl, and polyamine, wherein said alkyl, heterocyclyl and polyamine are optionally substituted with one to three substituents selected from R\u2032, or R 1  and R 2  can be taken together with the nitrogen to which they are attached to form a monocyclic heterocycle with 4-7 members optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic heterocycle is optionally substituted with one to three substituents selected from R\u2032; R 3  is selected from H and (C 1 -C 6 ) alkyl, said alkyl optionally substituted with one to three substituents selected from R\u2032; R\u2032 is independently selected from halogen, R\u2033, OR\u2033, SR\u2033, CN, CO 2 R\u2033 or CON(R\u2033) 2 ; R\u2033 is independently selected from H and (C 1 -C 6 ) alkyl, wherein said alkyl is optionally substituted with halogen and OH; n is 0, 1, 2, 3, 4 or 5; X is selected from O, NR\u2033, (C\u2550O)O, NR\u2033(C\u2550O), O(C\u2550O)O, NR\u2033(C\u2550O)NR\u2033, O(C\u2550O)NR\u2033, and NR\u2033(C\u2550O)O; L 1  is selected from C 4 -C 24  alkyl and C 4 -C 24  alkenyl, said alkyl and alkenyl are optionally substituted with one or more substituents selected from R\u2032; and L 2  is selected from C 3 -C 9  alkyl and C 3 -C 9  alkenyl, said alkyl and alkenyl are optionally substituted with one or more substituents selected from R\u2032; or any pharmaceutically acceptable salt or stereoisomer thereof.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 90.0
- Lexical Diversity: 1.47619
- Patent Class: 560.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15282294', '13880254', '14682494', '13876528', '14711246']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7602122687489709
- 35 USC 102 Novelty (BERT): 0.5955335851991512
- Combined Prediction Score: 0.7437444003939889
- Mean Citation Score: 418.058398
- Max Citation Score: 427.35324
- Similarity Product: 425.4352059460331

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test