PATENT CLAIM ANALYSIS

Application Number: 16220320
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-07
Patent Classification: ["424", "423000"]

Abstract:
A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and at least one closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, whereby the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface, which material shows an increased capacity to induce bone formation, and a process of preparation thereof.

Claim (Index 12):
A process of preparing the CAP/HAP bone substitute material of  claim 1 , comprising the steps of\n a) preparing a sintered CAP core material, b) immersing the sintered CAP core material in an aqueous buffered solution at a temperature between 10\u00b0 C. and 50\u00b0 C. to start a transformation process of CAP to HAP to form a uniform and closed epitactic grown layer of nanocrystalline hydroxyapatite on the sintered CAP core material surface, wherein the epitactically grown nanocrystals have the same size and morphology as human bone mineral, c) stopping the transformation by separating solid material from the aqueous buffered solution at a time when a uniform and closed coating of at least one nanocrystalline layer of HAP is present but before the transformation process is finished completely, washing the separated solid material by applying a washing protocol including pure water and a short-chained aliphatic alcohol solution as washing solutions to form the CAP/HAP bone substitute material in which the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, wherein the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface, and d) optionally sterilizing the separated material coming from step c).

Metadata:
- Claim Count in Document: 11.0
- Percentile: 98.0
- Lexical Diversity: 1.90541
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13997419', '13378867', '14903394', '14367145', '16045961']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7411396062604109
- 35 USC 102 Novelty (BERT): 0.5599364552770506
- Combined Prediction Score: 0.7230192911620749
- Mean Citation Score: 317.7468360000001
- Max Citation Score: 431.1168
- Similarity Product: 403.4534726852417

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test