PATENT CLAIM ANALYSIS

Application Number: 15749075
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "253120"]

Abstract:
The present invention discloses a crystal of citrate salt of pyridine-substituted 2-aminopyridine-based protein kinase inhibitors, in particular, to crystal of 5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-4′-methoxy-6′-((S)-2-methylpiperazin-1-yl)-3,3′-bipyridin-6-amine citrate salt, a method for preparation thereof, a crystalline composition and a pharmaceutical composition comprising the crystal, and further discloses the use of crystals of citrate salt of the compound of Formula I in protein kinase-related diseases. The crystals of citrate salt according to the present invention are superior to 5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-4′-methoxy-6′-((S)-2-methylpiperazin-1-yl)-3,3′-bipyridin-6-amine or other salts of 5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-4′-methoxy-6′-((S)-2-methylpiperazin-1-yl)-3,3′-bipyridin-6-amine in at least one aspect of bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, and the like.

Claim (Index 38):
Crystal form B of citrate salt of a compound of Formula I, characterized in that, in an X-ray powder diffraction pattern with Cu K\u03b1 radiation, characteristic peaks are present at 2\u03b8 angles of 6.74, 12.62, 18.42, 22.96 and 25.22 degrees, wherein the compound of Formula I has the following structure,

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 2.47692
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12885936', '11963192', '15539147', '15746966', '16098103']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7712361836062772
- 35 USC 102 Novelty (BERT): 0.5233201565647329
- Combined Prediction Score: 0.7464445809021227
- Mean Citation Score: 300.180814
- Max Citation Score: 316.9513
- Similarity Product: 259.41800244688994

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test