PATENT CLAIM ANALYSIS

Application Number: 15868395
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["424", "093700"]

Abstract:
The present invention concerns the enhancement of the osteogenic potential of bone graft by ex vivo treatment with a Wnt polypeptide, such as a liposomal Wnt polypeptide.

Claim (Index 1):
A method of repairing or rebuilding a diseased bone in a subject in need thereof, comprising:\n a) incubating a sample comprising isolated mammalian bone graft material comprising cells ex-vivo with a liposome comprising a Wnt protein to produce enhanced cells comprising an increased level of expression for one or more biomarkers comprising Runx2, Osterix, Osteocalcin, alkaline phosphatase, Axin2, Lef1, or Tcf4 relative to equivalent cells from bone graft material not incubated with a liposome comprising a Wnt protein; and b) administering the incubated enhanced cells into a target site of the diseased bone, thereby repairing or rebuilding the diseased bone.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 86.0
- Lexical Diversity: 1.20833
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15063317', '14333220', '14910616', '14337718', '13199820']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7679259364490867
- 35 USC 102 Novelty (BERT): 0.6851322048516887
- Combined Prediction Score: 0.7596465632893469
- Mean Citation Score: 552.4665620000002
- Max Citation Score: 771.0529
- Similarity Product: 660.8849821544288

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test