PATENT CLAIM ANALYSIS

Application Number: 15869250
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["548", "356100"]

Abstract:
Provided is an agent for the treatment or prophylaxis of inflammatory diseases, allergic diseases, autoimmune diseases, transplant rejection or the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as described in the specification.

Claim (Index 30):
A compound of formula [3] wherein R 1  is\n (1) a hydrogen atom, \n (2) a hydroxy group, or \n (3) a C 1-6  alkoxy group optionally substituted by C 6-10  aryl group(s); \n R 2  and R 3  are the same or different and each is\n a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (a) a hydroxy group, and \n (b) a C 1-6  alkoxy group; \n \n R 4  is a group selected from \u2003which is bonded to the 5-position or the 6-position of the indole ring,\n wherein \n R 5  is\n (1) a hydrogen atom, or \n (2) a C 1-6  alkyl group, and \n \n R 6  is\n (1) a hydrogen atom, \n (2) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (a) a hydroxy group, \n (b) a C 1-6  alkoxy group, \n (c) a carboxy group, \n (d) a C 1-6  alkoxy-carbonyl group, \n (e) a C 6-10  aryl group, \n (f) a C 6-10  aryloxy group, \n (g) an amino group optionally mono- or di-substituted by C 1-6  alkyl group(s), \n (h) a 5- or 6-membered unsaturated heterocyclic group optionally substituted by C 1-6  alkyl group(s), and \n (i) a 5- or 6-membered saturated heterocyclic group, \n \n (3) a C 1-6  alkoxy group, \n (4) a C 6-10  aryl group, or \n (5) a 5- or 6-membered unsaturated heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (a) a hydroxy group, and \n (b) a C 1-6  alkoxy group, or \n \n \n R 5  and R 6  form, together with the nitrogen atom they are bonded to, a 5- or 6-membered cyclic amine, wherein said cyclic amine is optionally condensed with a 5- or 6-membered unsaturated heterocycle, that is optionally substituted by 1 to 3 substituents selected from\n (a) a hydroxy group, \n (b) a C 1-6  alkyl group, \n (c) a C 1-6  alkoxy group, and \n (d) a C 1-6  alkoxy-carbonyl group; \n \n R 7  is\n a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (a) a hydroxy group, \n (b) a C 1-6  alkoxy group, and \n (c) an amino group optionally mono- or di-substituted by C 1-6  alkyl group(s), \n \n \n R 8  is\n (1) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (a) a hydroxy group, \n (b) a C 1-6  alkoxy group optionally substituted by C 6-10 aryl group(s), \n (c) a C 3-6  cycloalkyl group optionally substituted by C 1-6  alkoxy group(s), \n (d) a C 6-10  aryl group, \n (e) a 5- or 6-membered unsaturated heterocyclic group optionally substituted by oxo group(s), \n (f) a 5- to 8-membered saturated heterocyclic group optionally substituted by 1 to 3 substituents selected from \n \u2003(i) a hydroxy group, \n \u2003(ii) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from a hydroxy group and a C 1-6  alkoxy group, \n \u2003(iii) a C 1-6  alkoxy group, and \n \u2003(iv) an oxo group, \n (g) a C 3-6  cycloalkyloxy group, \n (h) a C 6-10  aryloxy group, \n (i) a 5- or 6-membered unsaturated heterocyclyloxy group, \n (j) a 5- or 6-membered saturated heterocyclyloxy group, and \n (k) an amino group optionally mono- or di-substituted by substituents selected from \n \u2003(i) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from a hydroxy group, a carboxy group and a carboxy-C 1-6  alkoxy group, \n \u2003(ii) a C 1-6  alkyl-carbonyl group optionally substituted by 1 to 3 substituents selected from a hydroxy group and a C 1-6  alkoxy group, \n \u2003(iii) a C 1-6  alkoxy-carbonyl group optionally substituted by C 6-10  aryl group(s), and \n \u2003(iv) a C 3-6  cycloalkyl-carbonyl group optionally substituted by C 1-6  alkoxy group(s), \n \n (2) a C 1-6  alkoxy group optionally substituted by C 6-10  aryl group(s), \n (3) a C 3-6  cycloalkyl group optionally substituted by 1 to 3 substituents selected from\n (a) a hydroxy group, and \n (b) a C 1-6  alkoxy group, \n \n (4) a C 6-10  aryl group optionally substituted by C 1-6  alkyl group(s) optionally substituted by 1 to 3 halogen atoms, \n (5) an amino group optionally mono- or di-substituted by C 1-6  alkyl group(s) optionally substituted by C 6-10  aryl group(s), \n (6) a 5- or 6-membered unsaturated heterocyclic group optionally substituted by C 1-6  alkyl group(s), \n (7) a 5- or 6-membered saturated heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (a) a C 1-6  alkyl group, \n (b) a C 1-6  alkyl-carbonyl group, and \n (c) an oxo group, \n \n (8) a C 3-6  cycloalkyloxy group, or \n (9) a C 6-10  aryl-carbonyl group, or \n \n R 7  and R 8  form, together with the nitrogen atom and carbon atom they are bonded to, a 5- or 6-membered cyclic amine substituted by an oxo group and optionally further substituted by 1 to 3 substituents selected from\n (a) a hydroxy group, \n (b) a C 1-6  alkyl group optionally substituted by hydroxy group(s), \n (c) a C 1-6  alkoxy group, and \n (d) a C 3-6  cycloalkyl group; and \n \n R 9  and R 10  are the same or different and each is an amino-protecting group selected from the group consisting of a tert-butoxycarbonyl group, an ethoxycarbonyl group, a trityl group, a tetrahydropyranyl group, a methoxymethyl group, a 2-(trimethylsilyl)ethoxymethyl group, and a p-toluenesulfonyl group.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 86.0
- Lexical Diversity: 1.35714
- Patent Class: 548.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12954438', '10645934', '14902309', '12065607', '15510225']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8368627947048448
- 35 USC 102 Novelty (BERT): 0.6267293734813024
- Combined Prediction Score: 0.8158494525824906
- Mean Citation Score: 426.174096
- Max Citation Score: 588.39124
- Similarity Product: 552.2114488469983

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test