PATENT CLAIM ANALYSIS

Application Number: 15951658
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "019300"]

Abstract:
Novel peptidomimetic compounds are disclosed, compounds that inhibit protein-protein interactions (PPI) of epidermal growth factor receptors (EGFR), also called human epidermal growth factor receptors (HERs), and that block signaling for cell growth in HER2-overexpressed cancers. The novel peptidomimetics specifically bind the HER2 protein, and thereby inhibit dimerization. The peptidomimetics disrupt both HER2-HER3 and EGFR-HER2 heterodimer formation. The peptidomimetics can be used in the treatment of various types of HER2-overexpressed cancers, including lung, breast, and ovarian cancers.

Claim (Index 2):
A compound having the following structure: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are each independently selected from the group consisting of C 1  to C 8  alkyl or substituted alkyl; C 1  to C 8  alkyl or substituted alkoxy; C 1  to C 8  alkyl or substituted alkenyl; C 1  to C 10  aryl, heteroaryl, substituted aryl, or substituted heteroaryl; C 1  to C 8  substituted or unsubstituted amino; amino acid; hydrogen; carboxyl; hydroxyl; or halide; wherein any of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 may be the same as or different from any other of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10; provided that at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is not hydrogen; and wherein R1 and R2 are each covalently bonded to any of the carbon atoms of the proline residue to which R1 and R2 are, respectively, shown as being adjacent in the structure depicted; and wherein said compound comprises at least one amino acid residue present primarily in the D-conformation; and wherein said compound comprises at least one chiral center in addition to the D-amino acid residue, and wherein an enantiomeric excess is present at said at least one chiral center.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 91.0
- Lexical Diversity: 1.60345
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15310238', '13700915', '11490438', '12157094', '15350801']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.783427357051133
- 35 USC 102 Novelty (BERT): 0.5794236640752861
- Combined Prediction Score: 0.7630269877535483
- Mean Citation Score: 290.384358
- Max Citation Score: 451.3511
- Similarity Product: 448.5552450102628

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test