PATENT CLAIM ANALYSIS

Application Number: 16087317
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["514", "260100"]

Abstract:
The invention describes a polymorph of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene[3,2-d]pyrimidine-6-carboxylic acid maleate and a preparation method therefor. The polymorph is a crystal having high stability and low hygroscopicity, and the crystal form is selected from crystal form A, crystal form B and crystal form C. Furthermore, the crystal form has a strong in-vivo hypoglycemic activity and can be used for the preparation of a novel drug for the treatment or prevention of diabetes mellitus type H and/or complications of diabetes mellitus type H.

Claim (Index 5):
The crystal form of  claim 1 , wherein the crystal form C has one or more characteristics selected from the group consisting of:\n (1) the X-ray powder diffraction pattern of the crystal form C includes 3 or more 2\u03b8 values selected from the group consisting of: 6.63\u00b10.2\u00b0, 11.16\u00b10.2\u00b0, 17.06\u00b10.2\u00b0, 19.46\u00b10.2\u00b0, 20.84\u00b10.2\u00b0, 25.74\u00b10.2\u00b0; and/or (2) the differential scanning calorimetry analysis spectrum (DSC spectrum) of the crystal form C has a characteristic peak within the range of 161\u00b15\u00b0 C.; and/or (3) the starting value of the endothermic transition temperature of the crystal form C is 147\u00b12\u00b0 C.; and/or (4) the thermogravimetric analysis pattern of the crystal form C comprises a characteristic absorption peak selected from the group consisting of: 183\u00b15\u00b0 C., 212\u00b15\u00b0 C., 289\u00b15\u00b0; and/or (5) the thermal weight loss of the crystal form C is 46-47 wt% at 400\u00b0 C.; and/or (6) the Raman spectrum of the crystal form C includes the following characteristic absorption peaks expressed by the wavelength \u03bb: 3383\u00b12 cm \u22121 , 3378\u00b12 cm \u22121 , 3370\u00b12 cm \u22121 , 3288\u00b12 cm \u22121 , 3163\u00b12 cm \u22121 , 2963\u00b12 cm \u22121 , 2230\u00b12 cm \u22121 , 1719\u00b12 cm \u22121 , 1558\u00b12 cm \u22121 , 1478\u00b12 cm \u22121 , 662\u00b12 cm \u22121 ; and/or (7) the IR pattern of the crystal form C includes the following characteristic absorption peaks expressed by the wavelength \u03bb: 3428\u00b12 cm \u22121 , 2936\u00b12 cm \u22121 , 1640\u00b12 cm \u22121 , 1514\u00b12 cm \u22121 , 1463\u00b12 cm \u22121 , 1418\u00b12 cm \u22121 , 1385\u00b12 cm \u22121 , 1272\u00b12 cm \u22121 , 1136\u00b12 cm \u22121 , 1022\u00b12 cm \u22121 , 874\u00b12 cm \u22121 , 766\u00b12 cm \u22121 , 599\u00b12 cm \u22121 .

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 1.63934
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16087318', '15549918', '15329813', '12870507', '15772946']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7350859351428867
- 35 USC 102 Novelty (BERT): 0.5337060722996991
- Combined Prediction Score: 0.7149479488585679
- Mean Citation Score: 247.14044600000005
- Max Citation Score: 348.92108
- Similarity Product: 293.47179327275035

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test