PATENT CLAIM ANALYSIS

Application Number: 16056163
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "211030"]

Abstract:
The present invention provides compounds that modulate protein function, to restore protein homeostasis and/or cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions of these compounds are also provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions are also provided.

Claim (Index 1):
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n Q 1  is CH 2 , O, NR 2 , S, or a bond; \n Q 2  is CH 2  or a bond; \n X is CH 2  or C\u2550O; \n X 1  is hydrogen, deuterium, methyl, or fluoro; \n Ring B is \n wherein Y 1  is N or CR 3A ; Y 2  is N or CR 3B ; Y 3  is N or CR 3C ; Y 4  is N or CR 3D ; Y 5  is N or CR 3E ;\n each R 1  is independently deuterium, hydroxyl, halogen, nitro, a substituted or unsubstituted amino, a substituted or unsubstituted C 1 -C 6  alkoxy, a substituted or unsubstituted C 1 -C 6  alkyl, a substituted or unsubstituted C 2 -C 6  alkenyl, a substituted or unsubstituted C 3 -C 8  cycloalkyl, a substituted or unsubstituted 3 to 10 membered heterocyclyl, a substituted or unsubstituted C 6 -C 10  aryl, a substituted or unsubstituted 5 to 10 membered heteroaryl, or L-Y; \n R 2  is Hydrogen, deuterium, a substituted or unsubstituted C 1 -C 6  alkyl, a substituted or unsubstituted C 2 -C 6  alkenyl, acyl, or \u2014(SO 2 )\u2014C 1 -C 6  alkyl; \n each R 3A , R 3B , R 3C , R 3D , and R 3E  is independently hydrogen, deuterium, hydroxyl, halogen, nitro, a substituted or unsubstituted amino, a substituted or unsubstituted C 1 -C 6  alkoxy, a substituted or unsubstituted C 1 -C 6  alkyl, a substituted or unsubstituted C 2 -C 6  alkenyl, a substituted or unsubstituted C 3 -C 8  cycloalkyl, a substituted or unsubstituted 3 to 10 membered heterocyclyl, a substituted or unsubstituted alkoxyalkyl, a substituted or unsubstituted cycloalkylalkyl, a substituted or unsubstituted heterocyclylalkyl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted heteroaralkyl, or L-Y; \n m is 0, 1, 2, or 3; \n n is 1, 2, or 3; \n L is \u2014Z 1 \u2014(R 4 ) t \u2014Z 2 \u2014; \u2014Z 1 \u2014(R 4 \u2014O\u2014R 4 ) t \u2014Z 2 \u2014; \u2014Z 1 (R 4 \u2014NH\u2014R 4 ) t \u2014Z 2 \u2014; \u2014Z 1 \u2014(R 4 \u2014(NHCO)\u2014R 4 ) t \u2014Z 2 \u2014; \u2014Z 1 \u2014(R 4 \u2014(NHC(O)NH)\u2014R 4 ) t \u2014Z 2 \u2014; or \u2014Z 1 \u2014(R 4 \u2014(CONH)\u2014R 4 ) t \u2014Z 2 \u2014; \n Z 1  and Z 2  are independently selected from \u2014NH\u2014; \u2014O\u2014; \u2014CH 2 \u2014; \u2014NH(CO)\u2014; \u2014(CO)NH\u2014; \u2014CH 2 NH\u2014; \u2014NHCH 2 \u2014; \u2014(CO)NHCH 2 \u2014; \u2014CH 2 CH 2 NH\u2014; \u2014CH 2 NH(CO)\u2014; or \u2014NHCH 2 CH 2 \u2014; \n each R 4  is independently an unsubstituted C 1 -C 6  alkylene; \n t is 1, 2, 3, 4, 5, or 6; and \n Y is \n wherein Y is derivatized to attach to L; and wherein at least one of Y 1 , Y 2 , Y 3 , Y 4 , and Y 5  is Y 5  is respectively R 3A , R 3B , R 3C , R 3D , or R 3E ; when Q 1  is CH 2  or a bond, then one or more of R 3A , R 3B , R 3C , R 3D , or R 3E  is not hydrogen; when R 1  is L-Y, none of R 3A , R 3B , R 3C , R 3D , and R 3E  is L-Y; and when Q 2  is a bond, Q 1  is a bond or CH 2 ; and when Q 1  is a bond, X 1  is hydrogen or methyl, and Q 2  is CH 2 ; then m is not 0; or when Q 1  is a bond, X 1  is hydrogen or methyl, and Q 2  is CH 2 ; then one of R 1 , R 3A , R 3B , R 3C , R 3D , and R 3E  is L-Y.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 96.0
- Lexical Diversity: 1.71795
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15847628', '16011090', '15599401', '15892267', '15916752']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8504991957531273
- 35 USC 102 Novelty (BERT): 0.5560545657353002
- Combined Prediction Score: 0.8210547327513446
- Mean Citation Score: 412.855082
- Max Citation Score: 429.14706
- Similarity Product: 304.5843106951797

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test