PATENT CLAIM ANALYSIS

Application Number: 15759872
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-07
Patent Classification: ["514", "229200"]

Abstract:
The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.

Claim (Index 1):
A compound represented by Formula (I): wherein, X is \u2014N\u2550 or \u2014CR a \u2550; R a  is selected from a hydrogen atom, a halogen atom, and C 1-6  alkyl; Y is selected from \u2014C(\u2550O)\u2014, \u2014CHR\u2014, and \u2014S(\u2550O) 2 \u2014; R is a hydrogen atom or C 1-6  alkyl; Q 1  is C 6-10  aryl or 5 to 10 membered heteroaryl, wherein C 6-10  aryl and 5 to 10 membered heteroaryl are optionally substituted with one to five substituents independently selected from a halogen atom, C 1-6  alkyl (wherein C 1-6  alkyl is optionally substituted with one or more halogen atoms), and C 1-6  alkoxy; Q 2  is 3 to 12 membered heterocyclyl or 5 to 10 membered heteroaryl, wherein 3 to 12 membered heterocyclyl and 5 to 10 membered heteroaryl are optionally substituted with one to three substituents independently selected from a halogen atom, C 1-6  alkyl (wherein C 1-6  alkyl is optionally substituted with one or more halogen atoms), C 1-6  alkoxy, and \u2014NR Qa R Qb , and two C 1-6  alkyl groups together with a carbon atom to which they are attached may form C 3-8  carbocyclic ring; and R Qa  and R Qb  are independently selected from a hydrogen atom, C 1-6  alkyl, and (C 1-6  alkyl)calbonyl; R 1 , R 2  and R 3  are each independently selected from a hydrogen atom and C 1-6  alkyl (wherein, C 1-6  alkyl is optionally substituted with one or more substituents independently selected from a halogen atom, C 1-6  alkoxy, and hydroxy); R 4 , R 5  and R 6  are independently selected from a hydrogen atom, a halogen atom, and C 1-6  alkyl; R 7  and R 8  are independently a hydrogen atom or C 1-6  alkyl, wherein C 1-6  alkyl is optionally substituted with one or more substituents independently selected from a halogen atom and C 3-15  cycloalkyl, or R 7  and R 8  together with a carbon atom to which they are attached may form C 3-15  cycloalkane ring, wherein C 3-15  cycloalkane ring formed by R 7  and R 8  together is optionally substituted with one to three C 1-6  alkyl, wherein C 1-6  alkyl is optionally substituted with one or more substituents independently selected from a halogen atom, hydroxy, \u2014NR 7a R 7b , C 1-6  alkoxy, and 3 to 12 membered heterocyclyl, and R 7a  and R 7b  are independently selected from a hydrogen atom, C 1-6  alkyl, and (C 1-6  alkyl)carbonyl; n1 is an integer of 0 to 3; n2 is an integer of 0 to 5; R 9  is selected from a group represented by Formula (IIa), (IIb), (IIc), (IId): \u2014CO 2 R 9f , and \u2014C(\u2550O)\u2014NR 9g R 9h ; and R 9a , R 9b , R 9c , R 9d , and R 9g  are each independently selected from a hydrogen atom, C 1-6  alkyl (wherein C 1-6  alkyl is optionally substituted with one or more substituents independently selected from a halogen atom and C 1-6  alkoxy), and (C 1-6  alkyl)carbonyl; R 9e  is a hydrogen atom, or C 1-6  alkyl that is optionally substituted with one or more halogen atoms; R 9f  is a hydrogen atom or C 1-6  alkyl; R 9h  is a hydrogen atom, C 1-6  alkyl, (C 1-6  alkyl)carbonyl, cyano, or \u2014S(\u2550O) n3 \u2014R 9i ; n3 is an integer of 0 to 2; and R 9i  is C 1-6  alkyl; Z 1  is selected from a group represented by Formula (IIIa), (IIIb), (IIIc), (IIId), and (IIIe): wherein R z a is selected from a hydrogen atom, C 1-6  alkyl, and (C 1-6  alkyl)carbonyl; R zb  and R zc  are independently a hydrogen atom or C 1-6  alkyl; n4 is an integer of 1 to 3; n5 and n6 are independently an integer of 0 to 10 (* represents a binding position with a pyrazolopyridine structure, and ** represents a binding position with Z 2 );\n Z 2  is selected from C 1-6  alkyl, C 3-15  cycloalkyl, 3 to 12 membered heterocyclyl, C 6-10  aryl and 5 to 10 membered heteroaryl, wherein C 3-15  cycloalkyl, 3 to 12 membered heterocyclyl, C 6-10  aryl, and 5 to 10 membered heteroaryl are optionally substituted with one to five substituents independently selected from Group A: \n Group A: a) oxo,\n b) a halogen atom, \n c) cyano, \n d) \u2014NR zd R ze ; wherein R zd  and R ze  are independently selected from a hydrogen atom, C 1-6  alkyl and (C 1-6  alkyl)carbonyl, wherein C 1-6  alkyl is optionally substituted with one or more substituents independently selected from hydroxy, a halogen atom and C 1-6  alkoxy, \n e) \u2014C(\u2550O)\u2014NR zf R zg ; wherein R zf  and R zg  are independently selected from a hydrogen atom, C 1-6  alkyl and (C 1-6  alkyl)carbonyl, wherein C 1-6  alkyl is optionally substituted with one or more substituents independently selected from hydroxy, a halogen atom and C 1-6  alkoxy, \n f) \u2014S(\u2550O) n7 \u2014R zh ; wherein n7 is an integer of 0 to 2; and R zh  is a hydrogen atom or C 1-6  alkyl, \n g) C 1-6  alkyl; wherein C 1-6  alkyl is optionally substituted with one or more substituent independently selected from a halogen atom, hydroxy, \u2014NR zi R zj , C 1-6  alkoxy, and 3 to 12 membered heterocyclyl, wherein R zi  and R zj  are independently a hydrogen atom or C 1-6  alkyl, and wherein 3 to 12 membered heterocyclyl is optionally substituted with one or more substituents independently selected from hydroxy, C 1-6  alkyl and 3 to 12 membered heterocyclyl, \n h) C 1-6  alkoxy; wherein C 1-6  alkoxy is optionally substituted with one or more substituent independently selected from hydroxy, a halogen atom, and C 1-6  alkoxy, \n i) 3 to 12 membered heterocyclyl; wherein 3 to 12 membered heterocyclyl is optionally substituted with one or more substituents independently selected from C 1-6  alkyl and (C 1-6  alkyl)carbonyl, \n j) C 6-10  aryl; wherein C 6-10  aryl is optionally substituted with one or more (C 1-6  alkyl)carbonyl, and \n k) 5 to 10 membered heteroaryl; wherein 5 to 10 membered heteroaryl is optionally substituted with one or more substituents independently selected from C 1-6  alkyl, C 1-6  alkoxy, \u2014NR zk R zl , and 3 to 12 membered heterocyclyl, wherein R zk  and Rzl are independently selected from a hydrogen atom, C 1-6  alkyl and (C 1-6  alkyl)carbonyl, and wherein 3 to 12 membered heterocyclyl is optionally substituted with one or more substituents independently selected from C 1-6  alkyl and (C 1-6  alkyl)carbonyl; \n a salt thereof, or a solvate of either the compound or a salt of the compound.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 90.0
- Lexical Diversity: 1.58824
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14852738', '13126490', '11778796', '14376307', '15523954']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7787936808217535
- 35 USC 102 Novelty (BERT): 0.5474530558071744
- Combined Prediction Score: 0.7556596183202956
- Mean Citation Score: 349.31223
- Max Citation Score: 389.41275
- Similarity Product: 275.76650327074526

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test