PATENT CLAIM ANALYSIS

Application Number: 16059072
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "345000"]

Abstract:
The present invention is directed to pyridin-2-one derivatives, pharmaceutical compositions containing them and their use as antagonists of the EP3 receptor, for the treatment of for example, impaired oral glucose tolerance, elevated fasting glucose, Type II Diabetes Mellitus, Syndrome X (also known as Metabolic Syndrome) and related disorders and complications thereof.

Claim (Index 1):
A compound of formula (I) wherein is selected from the group consisting of naphth-2-yl, indol-5-yl, indazol-5-yl, indazol-6-yl, benzimidazol-5-yl, benzimidazol-6-yl, benzothiazol-5-yl, benzothiazol-6-yl, benzoisothiazol-6-yl, chroman-7-yl, chromen-7-yl, benzo[d][1,3]dioxol-5-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl and 2,3-dihydro-benzo[b][1,4]dioxin-6-yl; wherein the naphth-2-yl, indol-5-yl, indazol-5-yl, indazol-6-yl, benzimidazol-5-yl, benzimidazol-6-yl, benzothiazol-5-yl, benzothiazol-6-yl, benzoisothiazol-6-yl, chroman-7-yl, chromen-7-yl, benzo[d][1,3]dioxol-5-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl or 2,3-dihydro-benzo[b][1,4]dioxin-6-yl, is optionally substituted on the phenyl portion of the bicycle with one to two substituents independently selected from the group consisting of halogen, oxo, cyano, C 1-3 alkyl, fluorinated C 1-2 alkyl, C 1-3 alkoxy, fluorinated C 1-2 alkoxy and C 3-6 cycloalkyl;\n and wherein the naphth-2-yl, indol-5-yl, indazol-5-yl, indazol-6-yl, benzimidazol-5-yl, benzimidazol-6-yl, benzothiazol-5-yl, benzothiazol-6-yl, benzoisothiazol-6-yl, chroman-7-yl, chromen-7-yl, benzo[d][1,3]dioxol-5-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl or 2,3-dihydro-benzo[b][1,4]dioxin-6-yl, is further optionally substituted on the \n portion of the bicycle with one to two substituents independently selected from the group consisting of halogen, oxo, cyano, C 1-3 alkyl, fluorinated C 1-2 alkyl, C 1-3 alkoxy, fluorinated C 1-2 alkoxy and C 3-6 cycloalkyl;\n R 1  is selected from the group consisting of hydrogen, halogen and C 1-4 alkyl; \n R 2  is selected from the group consisting of hydrogen, halogen and C 1-4  alkyl; \n is selected from the group consisting of CR A R B \u2014, \u2014CR A R B \u2014CH 2 \u2014, \u2014CH 2 \u2014CHR C \u2014, \u2014CR A R B \u2014CR C \u2550, \u2014C(R A )\u2550, \u2014CR A R B \u2014N(R D )\u2014, \u2014CR A R B \u2014CH 2 \u2014N(R D )\u2014, \u2014CR A R B \u2014C(O)\u2014N(R D )\u2014, \u2014CR A R B \u2014CH 2 \u2014C(O)\u2014N(R D )\u2014, \u2014CR A R B \u2014C(O)\u2014N(R D )\u2014SO 2 \u2014, \u2014CR A R B \u2014CH 2 \u2014C(O)\u2014N(R D )\u2014SO 2 \u2014, \u2014CR A R B \u2014N(R D )\u2014SO 2 \u2014, CR A R B \u2014CH 2 \u2014N(R D )\u2014SO 2 , and \u2014CR A R B \u2014CH 2 \u2014SO 2 \u2014; wherein the X group is incorporated in the orientation as listed; wherein R A  and R B  are each independently selected from the group consisting of hydrogen, fluoro, C 1-6 alkyl, fluorinated C 1-2 alkyl, C 3-6 cycloalkyl, phenyl, benzyl, phenyl-ethyl- and \u2014C(O)\u2014OC 1-2 alkyl; provided that when one of R A  or R B  is C 3-6 cycloalkyl, phenyl, benzyl, phenyl-ethyl- or \u2014C(O)O\u2014C 1-2 alkyl, then the other of R A  or R B  is hydrogen; alternatively, when X is selected from the group consisting of CR A R B \u2014, \u2014CR A R B \u2014CH 2 - and \u2014CR A R B \u2014CR C \u2550, R A  and R B  may be taken together with the carbon atom to which they are bound to form C 3-6 cycloalkyl; R C  is selected from the group consisting of hydrogen and C 1-3 alkyl; R D  is selected from the group consisting of hydrogen and C 1-3 alkyl; is selected from the group consisting of C 5-6 cycloalkyl, C 5-6 cycloalkenyl, phenyl, four to six membered monocyclic heterocyclyl and nine to ten membered bicyclic heterocyclyl; wherein the phenyl, four to six membered monocyclic heterocyclyl or nine to ten membered bicyclic heterocyclyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, oxo, C 1-4 alkyl, fluorinated C 1-2 alkyl, \u2014NR D R E , cyano, imino, cyanoimino, \u2014S\u2014(C 1-4  alkyl), \u2014SO\u2014(C 1-4 alkyl), \u2014SO 2 \u2014(C 1-4 alkyl), \u2014C(O)OH, \u2014C(O)O\u2014(C 1-3  alkyl) and \u2014C(O)\u2014NR D R E ; wherein R D  and R E  are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; or a tautomer or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 96.0
- Lexical Diversity: 1.2766
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16059074', '16059075', '13268387', '10502233', '12596685']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8269618099346604
- 35 USC 102 Novelty (BERT): 0.6517545762616008
- Combined Prediction Score: 0.8094410865673545
- Mean Citation Score: 464.728304
- Max Citation Score: 621.5414
- Similarity Product: 598.1215162493586

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test