PATENT CLAIM ANALYSIS

Application Number: 16087318
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-01
Patent Classification: ["514", "260100"]

Abstract:
The invention relates to a salt form of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene[3,2-d]pyrimidine-6-carboxylic acid and a preparation method for the salt form. Also disclosed is a pharmaceutical composition of the formula I compound salt form. The salt form of the invention provides powerful in vivo hypoglycemic activity and is expected to be a novel pharmaceutical active ingredient for treating or preventing diabetes mellitus type 2 and/or complications of diabetes mellitus type 2

Claim (Index 6):
The salt form of  claim 1  wherein the glycolate has one or more characteristics selected from the group consisting of:\n (1) the glycolate is a crystal; and/or \n (2) the X-ray powder diffraction pattern of the glycolate crystal includes 3 or more 2\u03b8 values selected from the group consisting of: 8.92\u00b10.2\u00b0, 10.20\u00b10.2\u00b0, 13.35\u00b10.2\u00b0, 16.89\u00b10.2\u00b0, 19.37\u00b10.2\u00b0; and/or \n (3) in the differential scanning calorimetry analysis spectrum (DSC spectrum) of the glycolate crystal, there is a characteristic absorption peak at 189\u00b15\u00b0 C.; and/or \n (4) the starting value of the endothermic transition temperature of the glycolate crystal is 148\u00b12\u00b0 C.; and/or \n (5) in the TG pattern of the glycolate crystal, there is a characteristic absorption peak at 192\u00b12\u00b0 C., 268\u00b12\u00b0 C.; and/or \n (6) the thermal weight loss of the glycolate crystal is 53-54 wt % at 400\u00b0 C.; and/or \n (7) the weight gain of the glycolate crystal is calculated to be \u22643%, preferably \u22641%, more preferably \u22640.3%, after being placed in a desiccator having a humidity of 50% for 24 hours and taken out; and/or \n (8) the IR pattern of the glycolate crystal includes three or more characteristic absorption peaks represented by the wavelength \u03bb selected from the group consisting of: 3462\u00b12 cm \u22121 , 2958\u00b12 cm \u22121 , 2837\u00b12 cm \u22121 , 2227\u00b12 cm \u22121 , 1720\u00b12 cm \u22121 , 1674\u00b12 cm \u22121 , 1558\u00b12 cm \u22121 , 1533\u00b12 cm \u22121 , 1450\u00b12 cm \u22121 , 1350\u00b12 cm \u22121 , 1282\u00b12 cm \u22121 , 1223\u00b12 cm \u22121 , 1072\u00b12 cm \u22121 , 928\u00b12 cm \u22121 , 760\u00b12 cm \u22121 , 692\u00b12 cm \u22121 .

Metadata:
- Claim Count in Document: 20.0
- Percentile: 97.0
- Lexical Diversity: 1.54545
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16087317', '16316055', '13522549', '14698463', '15746966']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7753790339424089
- 35 USC 102 Novelty (BERT): 0.5226707927291144
- Combined Prediction Score: 0.7501082098210795
- Mean Citation Score: 261.05123
- Max Citation Score: 316.59814
- Similarity Product: 248.8793736043823

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test