PATENT CLAIM ANALYSIS

Application Number: 15981979
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "284000"]

Abstract:
A derivative of isocorydine of formula I: wherein: R 1 ═   X═N, C, C═C; n 1 =0, 1    R 2 ═H, R 1  Y═C, N R 3 ═H, Cl, Br, F, CF 3 , OCH 3 , CH 3 ,   Z ═H, Cl, F, N; n 2 =0, 1  R 4 ═NH 2 , CH 2 NH 2 , NHCO(CH 2 ) n3 CH 3 , CH 2 NHCO(CH 2 ) n3 CH 3 , n 3 =0, 1, 2.   This derivative is prepared by amidation condensation reaction between an amino group of NICD and a carbonyl group of an aryl isocyanate, a carboxylic acid, or an acid chloride, or symmetrical amidation condensation reaction between an NICD and an aromatic amino group by solid phosgene. This derivative has anti-cancer activity in vivo and in vitro, and may be used for preventing and treating cancer.

Claim (Index 11):
The method of  claim 4  comprising: reacting NICD with the carboxylic acid or the acid chloride to form an amide functional group, wherein the carboxylic acid or the acid chloride is added to an organic solvent solution of NICD, a condensation catalyst is added to perform a condensation reaction with stirring, extraction is performed with di chloromethane after the reaction is complete, the solvent is recovered, and purification is conducted to obtain the derivative.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 2.28947
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13699869', '15762985', '12767647', '13379497', '14263886']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7142611444729935
- 35 USC 102 Novelty (BERT): 0.5174315524473169
- Combined Prediction Score: 0.6945781852704259
- Mean Citation Score: 271.156108
- Max Citation Score: 283.43286
- Similarity Product: 200.8780923109496

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test