PATENT CLAIM ANALYSIS

Application Number: 15975493
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-01
Patent Classification: ["424", "172100"]

Abstract:
The present invention relates to a protein binding to GARP in the presence of TGF-ß and uses thereof.

Claim (Index 9):
The protein according to  claim 1 , wherein the protein is an antibody or antigen binding fragment thereof, and wherein the variable region of the heavy chain comprises at least one of the following CDRs: VH-CDR1: (SEQ\u2003ID\u2003NO:\u20032) GFSLTGYGIN or (SEQ\u2003ID\u2003NO:\u200352) GYGIN;   VH-CDR2: (SEQ\u2003ID\u2003NO:\u20033) MIWSDGSTDYNSVLTS; and   VH-CDR3: (SEQ\u2003ID\u2003NO:\u20034) DRNYYDYDGAMDY, or any CDR having an amino acid sequence that shares at least 60% of identity with SEQ ID NO: 2-4 or 52, and the variable region of the light chain comprises at least one of the following CDRs: VL-CDR1: (SEQ\u2003ID\u2003NO:\u20035) KASDHIKNWLA;   VL-CDR2: (SEQ\u2003ID\u2003NO:\u20036) GATSLEA; and   VL-CDR3: (SEQ\u2003ID\u2003NO:\u20037) QQYWSTPWT, or any CDR having an amino acid sequence that shares at least 60% of identity with SEQ ID NO: 5-7; or the variable region of the heavy chain comprises at least one of the following CDRs: VH-CDR1: (SEQ\u2003ID\u2003NO:\u200313) SYYID;   VH-CDR2: (SEQ\u2003ID\u2003NO:\u200314) RIDPEDGGTKYAQKFQG; and   VH-CDR3: (SEQ\u2003ID\u2003NO:\u200315) NEWETVVVGDLMYEYEY, or any CDR having an amino acid sequence that shares at least 60% of identity with SEQ ID NO: 13-15, and the variable region of the light chain comprises at least one of the following CDRs: VL-CDR1: QASQX 1 I X 2 S X 3 LA (SEQ ID NO: 16), wherein X 1  is S or T, X 2  is S or V, X 3  is Y or F; VL-CDR2: X 1 X 2 SX 3 X 4 X 5 T (SEQ ID NO: 17), wherein X 1  is G or R; X 2  is A or T; X 3  is R or I; X 4  is L or P; X 5  is Q or K; and VL-CDR3: QQYX 1 SX 2 PX 3 T, wherein X 1  is D, A, Y or V; X 2  is A, L or V; X 3  is V or P (SEQ ID NO: 18), or any CDR having an amino acid sequence that shares at least 60% of identity with SEQ ID NO: 16-18.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 93.0
- Lexical Diversity: 1.05556
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14908368', '13288587', '15517108', '14279728', '13024698']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7360649212459266
- 35 USC 102 Novelty (BERT): 0.659714277505904
- Combined Prediction Score: 0.7284298568719243
- Mean Citation Score: 443.03607
- Max Citation Score: 706.23926
- Similarity Product: 584.0619461728822

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test