PATENT CLAIM ANALYSIS

Application Number: 15758712
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "300000"]

Abstract:
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

Claim (Index 51):
The compound of  claim 1 , wherein the compound is:\n Methyl 5-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-naphthoate; N-((4\u2032-(Dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-N-(naphthalen-1-yl)cyclohexanecarboxamide; Methyl 7-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-1H-indole-2-carboxylate; Methyl 4-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-1H-indole-2-carboxylate; Methyl 7-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-benzo[b]thiophene-2-carboxylate; Methyl 1-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-isoquinoline-6-carboxylate; Ethyl 8-(N-((4\u2032-(dimethyl amino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-quinoline-3-carboxylate; Methyl 7-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-naphthoate; Methyl 4-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-naphthoate; Methyl 1-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)pivalamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-isoquinoline-6-carboxylate; Ethyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-isoquinoline-6-carboxylate; Isopropyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-cyclohexanecarboxamido)isoquinoline-6-carboxylate; Ethyl 5-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-quinoline-2-carboxylate; Methyl 1-(N-((3\u2032-cyano-4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cycloheptanecarboxamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((2-cyano-4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)acetamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)isobutyramido)-isoquinoline-6-carboxylate; Methyl 1-(N-((2\u2032,3\u2032-difluoro-4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((3\u2032-cyano-4\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((3\u2032-chloro-4\u2032-cyano-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-chloro-3\u2032-cyano-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(3,3-dimethyl-N-(4-(6-(trifluoromethyl)pyridin-3-yl)benzyl)butanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-(4-(5-fluoro-6-methoxypyridin-3-yl)benzyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-(4-(5-chloro-6-methoxypyridin-3-yl)benzyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-(4-(6-methoxy-5-methylpyridin-3-yl)benzyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-(4-(6-(dimethylamino)pyridin-3-yl)benzyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(3,3-dimethyl-N-(4-(6-methylpyridin-3-yl)benzyl)butanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-cyclopropyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((3\u2032-chloro-4\u2032-(trifluoromethoxy)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-cyano-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-(hydroxymethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(3,3-dimethyl-N-(4-(1-methyl-1H-indol-5-yl)benzyl)butanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-(4-(2,3-dihydrobenzofuran-5-yl)benzyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-(4-(2,3-dihydrobenzofuran-6-yl)benzyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(3,3-dimethyl-N-(4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)butanamido)-isoquinoline-6-carboxylate; Methyl 1-(3,3-dimethyl-N-(4-(2-methylbenzo[d]thiazol-5-yl)benzyl)butanamido)isoquinoline-6-carboxylate; Methyl 1-(N-(4-(1-(tert-butoxycarbonyl)indolin-5-yl)benzyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-ethoxy-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-ethyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-fluoro-3\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((3\u2032-chloro-4\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-(difluoromethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-(difluoromethoxy)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-(methoxymethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-(2-methoxyethoxy)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-(2-hydroxyethoxy)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-(2-hydroxyethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-(2-methoxyethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-(4-(indolin-5-yl)benzyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(3,3-dimethyl-N-(4-(1-methylindolin-5-yl)benzyl)butanamido)isoquinoline-6-carboxylate; Methyl 1-(trans-4-hydroxy-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-cyclohexanecarboxamido)isoquinoline-6-carboxylate; Methyl 1-(trans-N-((3\u2032-chloro-4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)-4-hydroxycyclohexanecarboxamido)isoquinoline-6-carboxylate; Methyl 1-(trans-N-((3\u2032-cyano-4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)-4-hydroxycyclohexanecarboxamido)isoquinoline-6-carboxylate; Isopropyl 1-(N-((3\u2032-cyano-4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Isopropyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3-methylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclopentanecarboxamido)-isoquinoline-6-carboxylate; Methyl 1-(2-cyclopentyl-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)acetamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)benzamido)isoquinoline-6-carboxylate; Methyl 1-(2-cyclohexyl-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)acetamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-2-phenylacetamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-4,4-dimethylpentanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3-phenylpropanamido)-isoquinoline-6-carboxylate; Methyl 1-(4-(benzyloxy)-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-butanamido)isoquinoline-6-carboxylate; Methyl 1-(2-cyclobutyl-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)acetamido)-isoquinoline-6-carboxylate; Methyl 1-(2-cyclopropyl-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)acetamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)pentanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)butyramido)isoquinoline-6-carboxylate; Methyl 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-2-(oxetan-3-yl)acetamido)-isoquinoline-6-carboxylate; Methyl 1-(3-hydroxy-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)propanamido)-isoquinoline-6-carboxylate; Methyl 1-(4-hydroxy-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)butanamido)-isoquinoline-6-carboxylate; Methyl 1-(5-hydroxy-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)pentanamido)-isoquinoline-6-carboxylate; Isopropyl 1-(N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Isopropyl 1-(N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)-3,3-dimethylpentanamido)isoquinoline-6-carboxylate; Methyl 1-(3,3-dimethyl-N-((trans-4-(o-tolyl)cyclohexyl)methyl)butanamido)isoquinoline-6-carboxylate; Methyl 1-(3,3-dimethyl-N-((trans-4-(m-tolyl)cyclohexyl)methyl)butanamido)isoquinoline-6-carboxylate; Methyl 1-(3,3-dimethyl-N-((trans-4-(p-tolyl)cyclohexyl)methyl)butanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((trans-4-(2-methoxyphenyl)cyclohexyl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((trans-4-(3-methoxyphenyl)cyclohexyl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((trans-4-(4-methoxyphenyl)cyclohexyl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((trans-4-(4-chlorophenyl)cyclohexyl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylate; Methyl 1-(N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)cyclohexanecarboxamido)isoquinoline-6-carboxylate; Methyl 1-(N-((1-(4-methoxy-3-methylphenyl)piperidin-4-yl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylate; Methyl 1-(trans-4-hydroxy-N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)-cyclohexanecarboxamido)isoquinoline-6-carboxylate; 1-(N-((trans-4-(4-Methoxy-3-methylphenyl)cyclohexyl)methyl)-3,3-dimethylbutanamido)isoquinoline-6-carboxylic acid; 1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinoline-6-carboxylic acid; (E)-Methyl 3-(1-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)isoquinolin-6-yl)acrylate; (E)-3-(1-(N-((4\u2032-Methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinolin-6-yl)acrylic acid; 3-(1-(N-((4\u2032-Methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)-isoquinolin-6-yl)propanoic acid; or a pharmaceutically acceptable salt or solvate thereof.

Metadata:
- Claim Count in Document: 354.0
- Percentile: 90.0
- Lexical Diversity: 1.54839
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15758709', '15023465', '13992053', '15695911', '15036370']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7705235298664405
- 35 USC 102 Novelty (BERT): 0.5593302965012192
- Combined Prediction Score: 0.7494042065299183
- Mean Citation Score: 334.41643399999987
- Max Citation Score: 434.08496
- Similarity Product: 299.5089964305592

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test