PATENT CLAIM ANALYSIS

Application Number: 16025087
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "210210"]

Abstract:
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

Claim (Index 1):
A compound of formula (I) in which A represents CH 2 , CD 2  or CH(CH 3 ), R 1  represents (C 4 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl or phenyl,\n where (C 4 -C 6 )-alkyl may be substituted up to six times by fluorine, \n where (C 3 -C 7 )-cycloalkyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C 1 -C 4 )-alkyl, \n and \n where phenyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 6 )-cycloalkyl, (C 1 -C 4 )-alkoxy, difluoromethoxy and trifluoromethoxy, \n R 2  represents hydrogen, (C 1 -C 4 )-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl, R 3  represents a group of the formula where * represents the point of attachment to the carbonyl group, L 1A  represents a bond or (C 1 -C 4 )-alkanediyl,\n where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, \n L 1B  represents a bond or (C 1 -C 4 )-alkanediyl, L 1C  represents a bond or (C 1 -C 4 )-alkanediyl,\n where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, \n R 7  represents hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, cyano, 5- to 10-membered heteroaryl, naphthyl or phenyl,\n where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, phenyl, phenoxy and benzyloxy,\n where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, \n \n where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, \n and \n where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, \u2014NH(CO)CH 3 , (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkenyl, (C 1 -C 4 )-alkylsulphonyl, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkoxy, \n where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, \n and \n in which 2 adjacent carbon atoms of the phenyl may be substituted by a difluoromethylenedioxy bridge, \n R 8  represents hydrogen or (C 1 -C 4 )-alkyl, or R 7  and R 8  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,\n where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C 1 -C 4 )-alkyl, \n R 9  represents hydrogen, cyano, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, 5- to 10-membered heteroaryl or phenyl,\n where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, cyano, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxy-carbonyl, (C 1 -C 4 )-alkylsulphonyl, 5- or 6-membered heteroaryl, phenyl, phenoxy and benzyloxy,\n where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, \n where 5- or 6-membered heteroaryl may be benzo-fused or substituted by a 5- or 6-membered heteroaryl, \n \u2003where 5- or 6-membered heteroaryl may be substituted by (C 1 -C 4 )-alkyl or trifluoromethyl, \n \n where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, \n and \n where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkylsulphonyl, \n where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, \n and \n where the phenyl may be substituted on two adjacent carbon atoms by a difluoromethylenedioxy bridge, \n R 10  represents hydrogen or (C 1 -C 4 )-alkyl, or R 9  and R 10  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,\n where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, benzyl and (C 1 -C 4 )-alkyl, \n with the proviso that the radicals R 7  and R 9  do not both simultaneously represent phenyl, or R 7  and R 9  together with the carbon atoms to which they are attached and the group L 1B  form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,\n where the 3- to 7-membered carbocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C 1 -C 4 )-alkyl, fluorine, hydroxy and (C 1 -C 4 )-alkoxy, \n with the proviso that not more than one of the radical pairs R 7  and R 8 , R 9  and R 10  and R 7  and R 9 , respectively, simultaneously forms a carbo- or heterocycle, R 11  represents hydrogen or (C 1 -C 4 )-alkyl,\n where (C 1 -C 4 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy and (C 1 -C 4 )-alkoxy, \n R 12  represents hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, phenyl or benzyl,\n where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C 1 -C 4 )-alkoxy and phenoxy, \n and \n where phenyl and benzyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen and trifluoromethyl, \n or R 11  and R 12  together with the nitrogen atom to which they are attached form a 4- to 7-membered azaheterocycle,\n where the 4- to 7-membered azaheterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy, (C 1 -C 4 )-alkoxy and 4- to 7-membered heterocyclyl, \n and L 2  represents a bond or (C 1 -C 4 )-alkanediyl, R 13  represents 5- to 9-membered azaheterocyclyl which is attached via a ring carbon atom,\n where 5- to 9-membered azaheterocyclyl may be substituted by 1 to 5 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl and benzyl, \n and \n where 5- to 9-membered azaheterocyclyl may be fused to a phenyl ring which for its part may be substituted by 1 or 2 substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy and trifluoromethyl, \n or represents adamantyl, R 4  represents hydrogen, R 5  represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-alkynyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl, R 6  represents hydrogen, cyano or halogen, or a salt thereof.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 95.0
- Lexical Diversity: 1.68571
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15447205', '13789655', '14070180', '14909881', '13789414']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8868108377747984
- 35 USC 102 Novelty (BERT): 0.8118461344858627
- Combined Prediction Score: 0.8793143674459049
- Mean Citation Score: 850.3155519999997
- Max Citation Score: 1035.4594
- Similarity Product: 1030.8584323930263

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test