PATENT CLAIM ANALYSIS

Application Number: 15860174
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["424", "165100"]

Abstract:
The present invention provides antibodies that bind to  Staphylococcus aureus  Hemolysin A toxin, and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Hemolysin A. The antibodies of the invention are useful for inhibiting or neutralizing Hemolysin A activity, thus providing a means of preventing or treating a Hemolysin A-related disease or disorder such as  S. aureus  infection. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of a  S. aureus  infection.

Claim (Index 6):
The isolated human antibody or antigen-binding fragment thereof of  claim 1 , wherein the antibody or antigen-binding fragment comprises:\n (a) a HCDR1 domain comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 4, 24, 44, 64, 84, 104, 124, 144, 164, 184, 204, 224, 244, 264, and 284; (b) a HCDR2 domain comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 6, 26, 46, 66, 86, 106, 126, 146, 166, 186, 206, 226, 246, 266, and 286; (c) a HCDR3 domain comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 8, 28, 48, 68, 88, 108, 128, 148, 168, 188, 208, 228, 248, 268, and 288; (d) a LCDR1 domain comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 12, 32, 52, 72, 92, 112, 132, 152, 172, 192, 212, 232, 252, and 272; (e) a LCDR2 domain comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 14, 34, 54, 74, 94, 114, 134, 154, 174, 194, 214, 234, 254, and 274; and/or (f) a LCDR3 domain comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 16, 36, 56, 76, 96, 116, 136, 156, 176, 196, 216, 236, 256, and 276.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 86.0
- Lexical Diversity: 1.85185
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15289032', '15651387', '15005334', '14447444', '15637867']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7297157581780168
- 35 USC 102 Novelty (BERT): 0.5559526921496833
- Combined Prediction Score: 0.7123394515751835
- Mean Citation Score: 406.249138
- Max Citation Score: 415.6375
- Similarity Product: 355.3352135144173

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test