PATENT CLAIM ANALYSIS

Application Number: 15760170
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-02
Patent Classification: ["424", "450000"]

Abstract:
Lipid nanoparticles and methods of making and using the same, including pharmaceutical compositions and kits, and the targeted delivery of drugs in various treatment methods. The nanoparticle formulation includes phospholipids, triglycerides, cholesterol, cholesteryl ester, apolipoprotein E3 (ApoE3), and a lipophilic therapeutic agent.

Claim (Index 1):
A lipid nanoparticle, comprising a combination of:\n a phospholipid component, a triglyceride component, a cholesterol ester component, a free cholesterol component, an apolipoprotein component, and a therapeutic agent,\n wherein: \n the components are distributed so as to form a lipid core, surrounded by a phospholipid layer and a surfactant coating layer; \n the apolipoprotein component is human recombinant E3 apolipoprotein (ApoE3) and is bonded to a surface of the nanoparticle without Polysorbate 80; and \n the nanoparticle has an average size between 20 and 150 nm, a Z-potential between \u221225 and \u22125 my, and a PDI dispersion value between 0.08 and 0.30.

Metadata:
- Claim Count in Document: 66.0
- Percentile: 90.0
- Lexical Diversity: 1.35897
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10724833', '11648808', '11802197', '11513756', '11802727']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7185167314892639
- 35 USC 102 Novelty (BERT): 0.5183264153380088
- Combined Prediction Score: 0.6984976998741383
- Mean Citation Score: 279.559728
- Max Citation Score: 291.0936
- Similarity Product: 199.57326396989825

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test