PATENT CLAIM ANALYSIS

Application Number: 16109643
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "309000"]

Abstract:
Provided herein are compounds of Formula I, or a pharmaceutically acceptable salt thereof: which are useful as PARP inhibitors, as well as pharmaceutical compositions comprising them and methods for their use in treating disorders.

Claim (Index 1):
A compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein:\n R 1  is selected from the group of C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, \u2014(CH 2 ) n 1 -phenyl, \u2014(CH 2 ) n 2 -naphthalenyl, and \u2014(CH 2 ) n 3 -Het, wherein Het is a 5- to 10-membered heterocyclic group having 1, 2, 3, or 4 ring nitrogen atoms; with each of the R 1  C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl groups and the phenyl, naphthalenyl, and Het rings of the \u2014(CH 2 ) n 1 -phenyl, \u2014(CH 2 ) n 2 -naphthalenyl, and \u2014(CH 2 ) n 3 -Het groups, respectively, being independently substituted by 0, 1, 2, 3, 4, or 5 substituents selected from C 1 -C 6  alkyl, C 1 -C 6  alkoxy, OH, halogen, CF 3 , NH 2 , NH(C 1 -C 6  alkyl), N(C 1 -C 6  alkyl) 2 , CO 2 H, \u2014CO 2 (C 1 -C 6  alkyl), \u2014CO 2 -phenyl, \u2014CO 2 -benzyl, \u2014CO 2 \u2014C 3 -C 6  cycloalkyl, and \u2014CO 2 \u2014CH 2 \u2014C 3 -C 6  cycloalkyl; \n n 1 , n 2 , and n 3  are integers independently selected in each instance from 0, 1, 2, and 3; \n R 2  is selected from the group of H, halogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy, NH 2 , NH(C 1 -C 6  alkyl), and N(C 1 -C 6  alkyl) 2 , phenyl, \u2014O-phenyl, benzyl, and \u2014O-benzyl; with each of the R 2  C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl groups and the rings of the phenyl, \u2014O-phenyl, benzyl, and \u2014O-benzyl groups being independently substituted by 0, 1, 2, 3, 4, or 5 substituents selected from C 1 -C 6  alkyl, C 1 -C 6  alkoxy, OH, halogen, CF 3 , NH 2 , NH(C 1 -C 6  alkyl), and N(C 1 -C 6  alkyl) 2 ; \n R 3  is selected from H, C 1 -C 6  alkyl, and phenyl, with the C 1 -C 6  alkyl and phenyl groups being substituted by 0, 1, 2, 3, 4, or 5 substituents selected from C 1 -C 6  alkyl, C 1 -C 6  alkoxy, OH, halogen, CF 3 , NH 2 , NH(C 1 -C 6  alkyl), and N(C 1 -C 6  alkyl) 2 ; and \n R 4  is selected from H, CO 2 H, \u2014CO 2 (C 1 -C 6  alkyl), \u2014CO 2 -phenyl, \u2014CO 2 -benzyl, \u2014CO 2 \u2014C 3 -C 6  cycloalkyl, and \u2014CO 2 \u2014CH 2 \u2014C 3 -C 6  cycloalkyl, with the alkyl chain of the \u2014CO 2 (C 1 -C 6  alkyl) group and the rings of the \u2014CO 2 -phenyl, \u2014CO 2 -benzyl, \u2014CO 2 \u2014C 3 -C 6  cycloalkyl, and \u2014CO 2 \u2014CH 2 \u2014C 3 -C 6  cycloalkyl groups being substituted by 0, 1, 2, 3, 4, or 5 substituents selected from C 1 -C 6  alkyl, C 1 -C 6  alkoxy, OH, halogen, CF 3 , NH 2 , NH(C 1 -C 6  alkyl), and N(C 1 -C 6  alkyl) 2 ; \n with the proviso that, when R 1  is methyl and R 4  is CO 2 H, then R 2  is not H.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 96.0
- Lexical Diversity: 1.11765
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11535127', '10271715', '11567352', '14647088', '14991815']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7623031468631855
- 35 USC 102 Novelty (BERT): 0.5185336363517353
- Combined Prediction Score: 0.7379261958120404
- Mean Citation Score: 283.654396
- Max Citation Score: 287.6168
- Similarity Product: 210.90448800878525

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test