PATENT CLAIM ANALYSIS

Application Number: 15914587
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "450000"]

Abstract:
Provided are a pharmaceutical composition of an amorphous vortioxetine or a salt thereof, and a preparation method therefor. The pharmaceutical composition comprises an amorphous vortioxetine or a pharmaceutically acceptable salt thereof and two or more pharmaceutical excipients. The pharmaceutical composition has good stability and dispersity, and enhances the dissolution of vortioxetine or the pharmaceutically acceptable salt thereof, thereby improving the bioavailability of the medicinal formulation and the body absorption of the medicine.

Claim (Index 5):
The pharmaceutical composition of  claim 1 , wherein the vortioxetine is in the form of a hydrobromide salt, the pharmaceutical excipients comprise an organic carrier, an adsorbent and a pharmaceutical formulation excipient; wherein the vortioxetine hydrobromide salt forms a solid dispersion with the organic carrier, and the solid dispersion forms a composition with the adsorbent and the pharmaceutical formulation excipient; wherein the weight of vortioxetine hydrobromide salt is 20%\u02dc80% of the total weight of the solid dispersion, the weight of the adsorbent is 0.1%\u02dc100% of the weight of the solid dispersion, and the weight of the pharmaceutical formulation excipient is 0.1%\u02dc200% of the weight of the solid dispersion; and wherein the vortioxetine hydrobromide salt is amorphous, and X-ray powder diffraction pattern of the composition contains no characteristic peaks of vortioxetine hydrobromide crystals after deducting background peaks of the organic carrier, the adsorbent and the pharmaceutical formulation excipient.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 90.0
- Lexical Diversity: 1.95
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14916075', '15304929', '14429388', '15048868', '14902326']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7837896960076302
- 35 USC 102 Novelty (BERT): 0.5399587370993651
- Combined Prediction Score: 0.7594066001168037
- Mean Citation Score: 348.08949
- Max Citation Score: 392.5238
- Similarity Product: 262.8448898142338

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test