PATENT CLAIM ANALYSIS

Application Number: 16050142
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["424", "186100"]

Abstract:
Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.

Claim (Index 17):
The composition of  claim 9  wherein:\n i) the amino acid sequence of the consensus Zaire ebolavirus envelope glycoprotein immunogen is selected from the group consisting of: SEQ ID NO:1 (ZEBOV CON), a fragment of SEQ ID NO:1 that comprises 660 or more amino acids, an amino acid sequence that is 99% homologous to SEQ ID NO:1, a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:1 that comprises 660 or more amino acids; SEQ ID NO:1 (ZEBOV CON) linked to an IgE signal peptide, a fragment of SEQ ID NO:1 that comprises 660 or more amino acids linked to an IgE signal peptide, an amino acid sequence that is 99% homologous to SEQ ID NO:1 linked to an IgE signal peptide, and a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:1 that comprises 660 or more amino acids linked to an IgE signal peptide; \n ii) the amino acid sequence of the consensus Sudan ebolavirus envelope glycoprotein is selected from the group consisting of: SEQ ID NO:2 (SUDV CON), a fragment of SEQ ID NO:2 that comprises 660 or more amino acids, an amino acid sequence that is 99% homologous to SEQ ID NO:2, a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:2 that comprises 660 or more amino acids, SEQ ID NO:2 (SUDV CON) linked to an IgE signal peptide, a fragment of SEQ ID NO:2 that comprises 660 or more amino acids linked to an IgE signal peptide, an amino acid sequence that is 99% homologous to SEQ ID NO:2 linked to an IgE signal peptide, and a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:2 that comprises 660 or more amino acids linked to an IgE signal peptide; \n iii) the amino acid sequence of the first consensus Marburg marburgvirus envelope glycoprotein immunogen is selected from the group consisting of: SEQ ID NO:4 (MARV CON1), a fragment of SEQ ID NO:4 that comprises 660 or more amino acids, an amino acid sequence that is 99% homologous to SEQ ID NO:4, a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:4 that comprises 660 or more amino acids, SEQ ID NO:4 (MARV CON1) linked to an IgE signal peptide, a fragment of SEQ ID NO:4 that comprises 660 or more amino acids linked to an IgE signal peptide, an amino acid sequence that is 99% homologous to SEQ ID NO:4 linked to an IgE signal peptide, and a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:4 that comprises 660 or more amino acids linked to an IgE signal peptide; \n iv) the amino acid sequence of the second consensus Marburg marburgvirus envelope glycoprotein immunogen is selected from the group consisting of: SEQ ID NO:5 (MARV CON2), a fragment of SEQ ID NO:5 that comprises 660 or more amino acids, an amino acid sequence that is 99% homologous to SEQ ID NO:5, a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:5 that comprises 660 or more amino acids, SEQ ID NO:5 (MARV CON2) linked to an IgE signal peptide, a fragment of SEQ ID NO:5 that comprises 660 or more amino acids linked to an IgE signal peptide, an amino acid sequence that is 99% homologous to SEQ ID NO:5 linked to an IgE signal peptide, and a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:5 that comprises 660 or more amino acids linked to an IgE signal peptide; and \n v) the amino acid sequence of the third consensus Marburg marburgvirus envelope glycoprotein immunogen is selected from the group consisting of: SEQ ID NO:6 (MARV CON3), a fragment of SEQ ID NO:6 that comprises 660 or more amino acids, an amino acid sequence that is 99% homologous to SEQ ID NO:6, a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:6 that comprises 660 or more amino acids, SEQ ID NO:6 (MARV CON) linked to an IgE signal peptide, a fragment of SEQ ID NO:6 that comprises 660 or more amino acids linked to an IgE signal peptide, an amino acid sequence that is 99% homologous to SEQ ID NO:6 linked to an IgE signal peptide, and a fragment of an amino acid sequence that is 99% homologous to SEQ ID NO:6 that comprises 660 or more amino acids linked to an IgE signal peptide.

Metadata:
- Claim Count in Document: 63.0
- Percentile: 95.0
- Lexical Diversity: 2.23729
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14391952', '15431203', '15508851', '15507975', '15508288']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8632008208587519
- 35 USC 102 Novelty (BERT): 0.7510284719836111
- Combined Prediction Score: 0.8519835859712379
- Mean Citation Score: 721.305354
- Max Citation Score: 1035.5912
- Similarity Product: 861.8011482329371

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test