PATENT CLAIM ANALYSIS

Application Number: 15944483
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-12
Patent Classification: ["514", "04400A"]

Abstract:
Disclosed are molecules for treating non-del(5q) MDS that mimic allelic deficiency in del5q MDS to sensitize the malignant clones of patient without del(5q). The disclosed molecule contains an inhibitor of Cdc25C, an inhibitor of PP2Acα, or a combination thereof, and a toll like receptor-9 (TLR9) targeting ligand. The molecule can also contain lenalidomide, or an analogue or derivative thereof. Also disclosed is a composition comprising the disclosed molecule in a pharmaceutically acceptable carrier. Also disclosed is a method for treating non-del(5q) meylodysplastic syndrome (MDS) in a subject by administering to the subject a therapeutically effective amount of the disclosed pharmaceutical composition.

Claim (Index 5):
The molecule of  claim 1 , wherein the molecule is defined by the formula:\n TTL-IC-IP-LEN, or TTL-IP-IC-LEN, wherein \u201cTTL \u201d represents a TLR9 targeting ligand, wherein \u201cIC\u201d represents an inhibitor of Cdc25C, wherein \u201cIP\u201d represents an inhibitor of PP2Ac\u03b1, wherein \u201cLEN\u201d represents an lenalidomide, or an analogue or derivative thereof, and wherein \u201c-\u201d represents a bivalent linker.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 91.0
- Lexical Diversity: 1.78261
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14761641', '15682062', '14648306', '14902719', '15328235']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7197897965071136
- 35 USC 102 Novelty (BERT): 0.5967856921915485
- Combined Prediction Score: 0.7074893860755571
- Mean Citation Score: 282.474854
- Max Citation Score: 512.15216
- Similarity Product: 429.0115837566853

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test