PATENT CLAIM ANALYSIS

Application Number: 15766667
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "300000"]

Abstract:
The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.

Claim (Index 29):
A compound represented by Formula II, III, IV, or V: and pharmaceutically acceptable salts thereof, wherein:\n X 1  is selected from the group consisting of N and C(R X1 ); \n X 2  is selected from the group consisting of N and C(R X2 ); \n X 3  is selected from the group consisting of N and C(R X3 ); \n wherein only one of X 1 , X 2  or X 3  can be N; \n R 2  is selected from the group consisting of hydrogen, halogen, cyano, C 1-6 alkyl, C 1-6 alkoxy, and C 3-6 cycloalkyl; wherein C 1-6 alkyl, C 1-6 alkoxy, and C 3-6 cycloalkyl may optionally be substituted by one or more substituents each independently selected from the group consisting of halogen, hydroxyl, and phenyl; and wherein phenyl may optionally be substituted by one or more substituents each independently selected from R p ; \n R 3  is selected from the group consisting of hydrogen, halogen, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1, or 2), \u2014NR a \u2014C 1-6 alkyl, C 3-6 cycloalkoxy, \u2014S(O) w \u2014C 3-6 cycloalkyl (where w is 0, 1, or 2), \u2014NR a \u2014C 3-6 cycloalkyl, \u2014O-phenyl, \u2014S(O) w -phenyl (where w is 0, 1, or 2), \u2014NR a -phenyl, C 8-12 benzocycloalkoxy, \u2014NR a R b , \u2014OC(O)NR a -phenyl, \u2014NR a \u2014C(O)\u2014O\u2014 phenyl, \u2014NR a \u2014C(O)\u2014C 1-6 alkyl-phenyl, \u2014C 1-6 alkyl-NR a -phenyl, \u2014NR a \u2014C 1-6 alkyl-phenyl, and a 4-10 membered monocyclic, bridged bicyclic, or spirocyclic heterocyclyloxy, heterocyclyl-NR a \u2014, or heterocyclyl-S(O) w \u2014 moiety (where w is 0, 1, or 2) having one or two heteroatoms each independently selected from the group consisting of O, N, and S; wherein if said heterocyclyloxy, heterocyclyl-NR a \u2014, or heterocyclyl-S(O) w \u2014 ring contains an \u2014NH moiety, that nitrogen may optionally be substituted by a substituent selected from the group consisting of C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014O\u2014C 1-6 alkyl, and \u2014S(O) w \u2014C 1-3 alkyl (where w is 0, 1, or 2); and wherein said heterocyclyloxy, heterocyclyl-NR a \u2014, and heterocyclyl-S(O) w  may optionally be substituted by one, two, three, or four substituents each independently selected from R ff ; and wherein said phenyl moiety of \u2014O-phenyl, \u2014S(O) w -phenyl, \u2014NR a -phenyl, \u2014OC(O)NR a -phenyl, \u2014NR a \u2014C(O)\u2014O-phenyl, \u2014NR a \u2014C(O)\u2014C 1-6 alkyl-phenyl, \u2014C 1-6 alkyl-NR a -phenyl and \u2014NR a \u2014C 1-6 alkyl-phenyl may optionally be substituted by one, two, or three substituents each independently selected from R p ; and wherein C 1-6 alkoxy, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1, or 2), \u2014NR a \u2014C 1-6 alkyl, C 3-6 cycloalkoxy, \u2014S(O) w \u2014C 3-6 cycloalkyl (where w is 0, 1, or 2), and \u2014NR a \u2014C 3-6 cycloalkyl may optionally be substituted by one, two, or three substituents each independently selected from R gg ; \n R ff  is independently selected for each occurrence from the group consisting of halogen, hydroxyl, \u2014NR a R b , oxo, C 1-6 alkyl and C 1-6 alkoxy; \n R gg  is independently selected for each occurrence from the group consisting of halogen, hydroxyl, \u2014NR a R b , C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyl (optionally substituted by one, two or three substituents independently selected from the group consisting of halogen, hydroxyl, C 1-3 alkyl and C 1-3 alkoxy (optionally substituted by one, two or three fluorine atoms)), phenyl, a 5-6 membered monocyclic or 8-10 membered bicyclic heteroaryl having one, two or three heteroatoms each independently selected from the group consisting of O, N, and S, and a 4-10 membered monocyclic, bridged bicyclic, or spirocyclic heterocyclic ring having one or two heteroatoms each independently selected from the group consisting of O, N, and S; wherein if said heterocyclic ring contains an \u2014NH moiety, that nitrogen may optionally be substituted by a substituent selected from the group consisting of C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014O\u2014C 1-6 alkyl, and \u2014S(O) w \u2014C 1-3 alkyl (where w is 0, 1, or 2); and wherein phenyl may optionally be substituted by one, two, or three substituents each independently selected from R hh ; and wherein said 4-10 membered monocyclic, bridged bicyclic, or spirocyclic heterocyclic ring may optionally be substituted by one, two, three, or four substituents each independently selected from R ii ; \n R hh  is independently selected for each occurrence from the group consisting of halogen, cyano, C 1-6  alkyl, C 1-6 alkoxy, S(O) w \u2014C 1-3 alkyl, \u2014S(O) w \u2014NR a R b , \u2014NR a \u2014S(O) w \u2014C 1-3 alkyl (where w is 0, 1, or 2), a 5-6 membered monocyclic heteroaryl having one, two or three heteroatoms each independently selected from the group consisting of O, N, and S, and a 4-7 membered heterocyclic ring having one or two heteroatoms each independently selected from the group consisting of O, N, and S; wherein C 1-6 alkoxy and S(O) w \u2014C 1-3 alkyl may optionally be substituted by one, two, or three halogens; \n R ii  is independently selected for each occurrence from the group consisting of halogen, hydroxyl, \u2014NR a R b , oxo, C 1-6 alkyl and C 1-6 alkoxy; \n R A1  is independently for each occurrence selected from the group consisting of hydrogen, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 3-6 cycloalkyl, phenyl, \u2014NR a R b , \u2014O\u2014C(O)\u2014NR a -phenyl, \u2014NR a \u2014C(O)-phenyl, and \u2014NR a \u2014C 1-4 alkyl-phenyl; wherein C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 3-6 cycloalkyl and phenyl may optionally be substituted by one or more substituents selected from the group consisting of halogen, hydroxyl, phenyl, and \u2014NR a R b ; \n R X1  is selected from the group consisting of hydrogen, \u2014C(O)OH, and C 1-6 alkyl; wherein C 1-6 alkyl may optionally be substituted by one, two or three halogens; \n R X2  is selected from the group consisting of hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy, and \u2014C 1-6 alkox-phenyl; wherein phenyl may optionally be substituted by one or more substituents selected from R p ; \n R X3  is selected from the group consisting of hydrogen, halogen, cyano, C 1-6 alkyl, C 1-6 alkoxy, \u2014C 1-6 alkoxy-phenyl, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, and phenyl; wherein C 1-6 alkyl and C 1-6 alkoxy may optionally be substituted by one, two, or three substituents selected from the group consisting of hydroxyl and halogen; and wherein phenyl may optionally be substituted by one or more substituents selected from R p ; \n R a  and R b  are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, phenyl, \u2014C(O)-phenyl, and \u2014C(O)\u2014C 1-6 alkyl; or \n R a  and R b  taken together with the nitrogen to which they are attached form a heterocyclic ring; and \n R p  is independently selected, for each occurrence, from the group consisting of halogen, hydroxyl, cyano, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, phenyl, C 3-6 cycloalkoxy, \u2014S(O) w \u2014C 1-3 alkyl (where w is 0, 1, or 2), \u2014S(O) w \u2014NR a R b , and \u2014NR a R b .

Metadata:
- Claim Count in Document: 140.0
- Percentile: 91.0
- Lexical Diversity: 1.04545
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15747290', '15539392', '16091401', '15539397', '15320172']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8350993449715051
- 35 USC 102 Novelty (BERT): 0.5324987354995494
- Combined Prediction Score: 0.8048392840243095
- Mean Citation Score: 357.125496
- Max Citation Score: 371.4623
- Similarity Product: 270.6131670524836

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test