PATENT CLAIM ANALYSIS

Application Number: 15762985
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "449000"]

Abstract:
The present invention discloses a water-soluble docetaxel anticancer drug compound having the structure of Formula I below: in which R=—CH 3 , —CH 2 CH 3 , —CH 2 CH 2 CH 3 , or —CH 2 CH 2 CH 2 CH 3 ; and n=5-500. The active moiety docetaxel in the anticancer drug compound is covalently conjugated to a polyethylene glycol monoalkyl ether through a linker diglycoloyl (carbonyl methoxyacetyl) to form the water-soluble docetaxel anticancer drug compound. The present invention also relates to a preparation method of the drug compound and use thereof.

Claim (Index 3):
A method for preparing a water-soluble docetaxel anticancer drug compound according to  claim 1 , comprising of the following steps:\n 1) A polyethylene glycol monoalkyl ether reacts with diglycolic acid or diglycolic anhydride to produce a polyethylene glycol monoalkyl ether monodiglycolate; and 2) The polyethylene glycol monoalkyl ether monodiglycolate, or an acyl chlorinated product of the polyethylene glycol monoalkyl ether monodiglycolate obtained in Step 1) reacts with docetaxel to produce the water-soluble docetaxel anticancer drug compound (I).

Metadata:
- Claim Count in Document: 1.0
- Percentile: 90.0
- Lexical Diversity: 1.81818
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14438409', '15125543', '14764166', '15520956', '13319175']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7143281153847381
- 35 USC 102 Novelty (BERT): 0.504580879757823
- Combined Prediction Score: 0.6933533918220466
- Mean Citation Score: 235.69536800000003
- Max Citation Score: 248.05731
- Similarity Product: 183.53467441557885

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test