PATENT CLAIM ANALYSIS

Application Number: 16304634
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-09
Patent Classification: ["540", "575000"]

Abstract:
Relating to processes for preparing suvorexant or its pharmaceutically acceptable salts through the formation of a cocrystal of (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate hydrochloride with (R)-(+)-1,1,2-triphenyl-1,2-ethanediol ((R)-TED). This cocrystal provides the resolution of an intermediate of suvorexant, in particular, of (rac)-benzyl5-methyl-1,4-diazepane-1-carboxy-lateor a hydrochloride salt thereof. It also relates to a new cocrystal useful in such preparation processes.

Claim (Index 5):
A resolution process of (rac)-benzyl 5-methyl-1,4-diazepane-1-carboxylate of formula (rac)-(III) or a salt thereof, which comprises\n a) preparing a cocrystal of (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate hydrochloride with (R)-TED of formula (II) as defined in  claim 1  by a process which comprises the steps of: a 1 ) combining either a 1a ) a mixture of a hydrochloride salt of (rac)-benzyl 5-methyl-1,4-diazepane-1-carboxylate of formula (rac)-(III) and (R)-(+)-1,1,2-triphenyl-1,2-ethanediol ((R)-TED) or, alternatively, a 1b ) (rac)-benzyl 5-methyl-1,4-diazepane-1-carboxylate of formula (rac)-(III), (R)-TED and hydrochloric acid; in a solvent selected from the group consisting of acetonitrile, isopropanol, ethyl acetate, acetone, tetrahydrofuran, tert-butyl methyl ether and toluene; a 2 ) either heating the mixture thus obtained until complete dissolution or, alternatively, slurrying between room temperature and reflux; a 3 ) cooling down this mixture if necessary; and a 4 ) isolating the cocrystal of formula (II) obtained in steps a 2 ) or a 3 ); and b) converting the cocrystal obtained in step a 4 ) into (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate or a salt thereof.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 98.0
- Lexical Diversity: 1.60417
- Patent Class: 540.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16073929', '15501295', '12061499', '13147337', '10536618']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6882090806099356
- 35 USC 102 Novelty (BERT): 0.5168838230686895
- Combined Prediction Score: 0.6710765548558111
- Mean Citation Score: 238.975446
- Max Citation Score: 276.726
- Similarity Product: 201.0685648913384

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test