PATENT CLAIM ANALYSIS

Application Number: 15874338
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["530", "300000"]

Abstract:
The present invention is directed to an inventive polymeric carrier molecule according to generic formula (I) and variations thereof, which allows for efficient transfection of nucleic acids into cells in vivo and in vitro, a polymeric carrier cargo complex formed by a nucleic acid and the inventive polymeric carrier molecule, but also to methods of preparation of this inventive polymeric carrier molecule and of the inventive polymeric carrier cargo complex. The present invention also provides methods of application and use of this inventive polymeric carrier molecule and the inventive polymeric carrier cargo complex as a medicament, for the treatment of various diseases, and in the preparation of a pharmaceutical composition for the treatment of such diseases.

Claim (Index 1):
Polymeric carrier molecule according to formula (I):\n L-P 1 \u2014S\u2014[S\u2014P 2 \u2014S] n \u2014S\u2014P 3 -L wherein, P 1  and P 3  are different or identical to each other and represent a linear or branched hydrophilic polymer chain, each P 1  and P 3  exhibiting at least one \u2014SH-moiety, capable to form a disulfide linkage upon condensation with component P 2 , the linear or branched hydrophilic polymer chain selected independent from each other from polyethylene glycol (PEG), poly-N-(2-hydroxypropyl)methacrylamide, poly-2-(methacryloyloxy)ethyl phosphorylcholines, poly(hydroxyalkyl L-asparagine), poly(2-(methacryloyloxy)ethyl phosphorylcholine), hydroxyethylstarch or poly(hydroxyalkyl L-glutamine), wherein the hydrophilic polymer chain exhibits a molecular weight of about 1 kDa to about 100 kDa, P 2  is a cationic or polycationic peptide or protein, having a length of about 3 to about 100 amino acids, or\n is a cationic or polycationic polymer, having a molecular weight of about 0.5 kDa to about 30 kDa, \n each P 2  exhibiting at least two \u2014SH-moieties, capable to form a disulfide linkage upon condensation with further components P 2  or component(s) P 1  and/or P 3 ; \n S\u2014S\u2014 is a (reversible) disulfide bond; L is an optional ligand, which may be present or not, and may be selected independent from the other from RGD, Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence (NLS), an antibody, a cell penetrating peptide, TAT, a ligand of a receptor, cytokines, hormones, growth factors, small molecules, carbohydrates, mannose, galactose, synthetic ligands, small molecule agonists, inhibitors or a antagonists of receptors, or RGD peptidomimetic analogues; and n is an integer, selected from a range of about 1 to 50, preferably in a range of about 1, 2, 3, 4, or 5 to 10, more preferably in a range of about 1, 2, 3, or 4 to 9.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 86.0
- Lexical Diversity: 2.15517
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14195864', '13378241', '15065769', '13824449', '15206036']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7955268646387879
- 35 USC 102 Novelty (BERT): 0.7188240804608859
- Combined Prediction Score: 0.7878565862209976
- Mean Citation Score: 736.1370539999997
- Max Citation Score: 869.1829
- Similarity Product: 754.2897147115171

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test