PATENT CLAIM ANALYSIS

Application Number: 16327372
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["424", "001890"]

Abstract:
Radiofluorinated carboximidamides are disclosed as selective IDO enzyme radioligands and generate specific binding in accordance with IDO expression in vitro. MicroPET experiments indicate [ 18 F]IDO49 specifically accumulate in IDO-expressing tumors which confirmed by Western blot and IHC analysis supported. Using Hela tumor bearing models with IFN-γ treatment confirmed that [ 18 F]IDO49 accumulation in the IFN-γ treatment tumor mouse. These results can have implications that [ 18 F]IDO49 has substantial potential as an imaging agent that targets IDO in tumors.

Claim (Index 1):
A compound having Formula I: wherein, R 1  is hydrogen, C 1 -C 8  alkyl, C 1 -C 8  alkenyl, C 1 -C 8  alkynyl, C 1 -C 8  haloalkyl, C 1 -C 8  haloalkenyl, C 1 -C 8  haloalkynyl, C 5 -C 6  cycloalkyl, C 5 -C 6  heterocycloalkyl, aryl, C 1 -C 3  alkylheteroaryl, heteroaryl, C(O)NR 6 R 7 , NHC(O)R 6 , or \u2014O\u2014 N\u2550R 6 , any of which is optionally substituted with carbonyl (C\u2550O), carboxyl (\u2014CO 2 \u2014), ester (CO 2 R 6 ), C 1 -C 6  alkyl, C 1 -C6 alkoxyl, amino, \u2014NR 6 R 7 , \u2014C(O)NR 6 R 7 , C 1 -C 6  alkylhydroxy, C 5 -C 6  cycloalkyl, C 5 -C 6  heterocycloalkyl, aryl, heteroaryl, halo, hydroxy, thiol, cyano, nitro, radiolabeled isotope; R 2  is hydrogen, halogen, C 1 -C 8  alkyl, C 1 -C 8  alkenyl, C 1 -C 8  alkynyl, C 1 -C 8  haloalkyl, C 1 -C 8  haloalkenyl, C 1 - C 8  haloalkynyl, C 5 -C 6  cycloalkyl, C 5 -C 6  heterocycloalkyl, aryl, C 1 -C 3  alkylheteroaryl, or heteroaryl, any of which is optionally substituted with carbonyl (C\u2550O), carboxyl (\u2014CO 2 \u2014), ester (CO 2 R 6 ), C 1 -C 6  alkyl, C 1 -C 6  alkoxyl, amino, \u2014NR 6 R 7 , \u2014C(O)NR 6 R 7 , C 1 -C 6  alkylhydroxy, C 5 -C 6  cycloalkyl, C 5 -C 6  heterocycloalkyl, aryl, heteroaryl, haloaryl, halo, hydroxy, thiol, cyano, nitro, radiolabeled isotope; and R 6  and R 7  are independently selected from hydrogen, C 1 -C 8  alkyl, C 1 -C 8  alkenyl, C 1 -C 8  alkynyl, C 1 -C 8  haloalkyl, C 1 - C 8  haloalkenyl, C 1 -C 8  haloalkynyl, C 5 -C 6  cycloalkyl, C 5 -C 6  heterocycloalkyl, aryl, C 1 -C 3  alkylheteroaryl, or heteroaryl; any of which is optionally substituted with a halogen; with the proviso that when R 1  is H, R 2  is not Cl, or a pharmaceutically salt thereof.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 99.0
- Lexical Diversity: 1.46774
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13070069', '13050143', '11641284', '15564666', '13780510']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7280992099645929
- 35 USC 102 Novelty (BERT): 0.5166799406586587
- Combined Prediction Score: 0.7069572830339995
- Mean Citation Score: 288.155004
- Max Citation Score: 295.71445
- Similarity Product: 202.91929755387304

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test