PATENT CLAIM ANALYSIS

Application Number: 16005488
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "230500"]

Abstract:
The present invention provides compounds represented by formula (I), pharmaceutically acceptable salts thereof, N-oxides thereof, solvates thereof or prodrugs thereof (wherein the characters are as defined in the description). The compounds represented by formula (I) have affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 (GABA A  α5) and act as GABA A  α5 negative allosteric modulators (GABA A  α5 NAM), so that they are useful in the prevention and/or treatment of diseases which are related to the GABA A  α5 such as Alzheimer's disease.

Claim (Index 9):
The compound according to  claim 1 , wherein wherein E 1 , E 2  and E 4  each independently represent a carbon atom or a nitrogen atom, with the proviso that at least two of E 1 , E 2  and E 4  are carbon atoms; R 3a  represents (1) hydrogen, (2) C1-4 alkyl which may be substituted with 1 to 3 groups selected from halogen, hydroxy and methoxy or (3) \u2014(CH 2 ) p -(3- to 5-membered cycloalkyl), wherein one carbon atom in cycloalkyl may be replaced by oxygen and p represents 0 or 1; R 3b  and R 3c  each independently represent (1) hydrogen, (2) halogen or (3) C1-4 alkyl; R 3d  represents halogen or C1-4 alkyl; md represents an integer of 0 to 2, wherein when md represents 2, each R 3d  may be same or different; monocyclic 1  represents (1) 5- to 7-membered mono-cyclic aromatic carbocyclic ring which may be partially saturated or (2) 5- to 7-membered mono-cyclic aromatic heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen and sulfur, which may be partially saturated; and the arrow represents a binding position to the N(R 2 ).

Metadata:
- Claim Count in Document: 27.0
- Percentile: 94.0
- Lexical Diversity: 1.64062
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15112647', '14208067', '14376307', '10149852', '11942480']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8107843950064564
- 35 USC 102 Novelty (BERT): 0.6032302415243419
- Combined Prediction Score: 0.7900289796582449
- Mean Citation Score: 380.78577
- Max Citation Score: 515.1568
- Similarity Product: 501.3724721838951

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test