PATENT CLAIM ANALYSIS

Application Number: 15921890
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "318000"]

Abstract:
The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.

Claim (Index 1):
A compound of formula (I): or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein\n X 1  is selected from CR 1 , N, and N\u2014O; \n X 2  is selected from CR 2 , N, and N\u2014O; \n X 3  is selected from CR 3 , N, and N\u2014O; \n X 4  is selected from CR 4 , N, and N\u2014O; \n R 1 , R 2 , R 3 , R 4 , and R 5  are independently selected from hydrogen; halogen; C 1 -C 6  alkyl; C 2 -C 6  alkenyl; C 2 -C 6  alkynyl; C 1 -C 6  haloalkyl; (C 1 -C 6  alkyl)-OR 20 ; OH; O(C 1 -C 6  alkyl); OCF 3 ; OCF 2 H; OCFH 2 ; CN; N 3 ; NO 2 ; NH 2 ; NH(C 1 -C 6  alkyl); N(C 1 -C 6  alkyl) 2 ; NR 20 C(O)R 20 ; C(O)NR 20 R 20 ; COR 20 ; CO(C 1 -C 6  alkyl); S(O) p R 20 ; NR 20 S(O) p R 20 ; S(O) p NR 20 R 20 ; SR 20 ; SCF 3 ; COOR 20 ; OR 20 ; (C 1 -C 6  alkyl)-R 20 ; 3-7 membered saturated, partially saturated, or unsaturated carbocycle; and 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur;\n alternatively, two substituents selected from R 1 , R 2 , R 3 , R 4 , and R 5  on two adjacent carbon atoms taken together form a 3-7 membered saturated, partially saturated, or unsaturated carbocycle; or a 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; where the carbocycle or heterocycle is optionally substituted with one or more R 20 ; \n \n R 20  is independently selected from hydrogen; C 1 -C 6  alkyl; CN; (C 1 -C 6  alkyl)-NR 21 R 21 ; (C 1 -C 6  alkyl)-OR 21 ; 3-7 membered saturated, partially saturated, or unsaturated carbocycle; 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; (C 1 -C 6  alkyl)-3-7 membered saturated, partially saturated, or unsaturated carbocycle; (C 1 -C 6  alkyl)-3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; where the carbocycle or heterocycle is optionally substituted with one or more R 21 ; \n or two R 20  taken together with the carbon atom to which they are attached form a carbonyl; \n R 21  is independently selected from hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl; OH, O\u2014(C 1 -C 6  alkyl), O\u2014(C 2 -C 6  alkenyl), and O\u2014(C 2 -C 6  alkynyl); \n Y 6  is independently selected from CR 6 , N, and N\u2014O; \n Y 7  is independently selected from CR 7 , N, and N\u2014O; \n Y 8  is independently selected from CR 8 , N, and N\u2014O; \n Y 9  is independently selected from CR 9 , N, and N\u2014O; \n R 6 , R 7 , R 8 , and R 9  are independently selected from hydrogen; halogen; C 1 -C 6  alkyl; C 2 -C 6  alkenyl; C 2 -C 6  alkynyl; C 1 -C 6  haloalkyl; (C 1 -C 6  alkyl)-R 30 ; (C 1 -C 6  alkyl)-OR 30 ; OH; O(C 1 -C 6  alkyl); OCF 3 ; OCF 2 H; OCFH 2 ; CN; N 3 ; NO 2 ; NH 2 ; NH(C 1 -C 6  alkyl); N(C 1 -C 6  alkyl) 2 ; NR 30 C(O)R 30 ; C(O)NR 30 R 30 ; COR 30 ; CO(C 1 -C 6  alkyl); S(O) q R 30 ; NR 30 S(O) q R 30 ; S(O) q NR 30 R 30 ; SR 30 ; SCF 3 ; and COOR 30 ;\n alternatively, two substituents selected from R 6 , R 7 , R 8 , and R 9  on two adjacent carbon atoms taken together form a 3-7 membered saturated, partially saturated, or unsaturated carbocycle; or a 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; where the carbocycle or heterocycle is optionally substituted with one or more R 30 ; \n \n R 30  is independently selected from hydrogen; C 1 -C 6  alkyl; (C 1 -C 6  alkyl)-R 31 ; (C 1 -C 6  alkyl)-OR 31 ; (C 1 -C 6  alkyl)-NR 31 R 31 ; 3-7 membered saturated, partially saturated, or unsaturated carbocycle; and 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; where the carbocycle or heterocycle is optionally substituted with one or more R 31 ; \n R 31  is independently selected from hydrogen; C 1 -C 6  alkyl; 3-7 membered saturated, partially saturated, or unsaturated carbocycle; and 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; \n G is selected from a bond, O, S, S(O), S(O) 2 , CH 2 , CH 2 CH 2 , and CHCH; \n alternatively, G and R a1  together form a 3-7 membered saturated, partially saturated, or unsaturated carbocycle; or a 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; \n A is selected from a bond, CH 2 , CH 2 CH 2 , CH 2 CH 2 CH 2 , CHCH, and C\u2261C; \n R a1  and R a2  are independently selected from hydrogen; halogen; C 1 -C 6  alkyl; C 2 -C 6  alkenyl; C 2 -C 6  alkynyl; C 1 -C 6  haloalkyl; OH; O(C 1 -C 6  alkyl); (C 1 -C 6  alkyl)-OH; (C 1 -C 6  alkyl)-O(C 1 -C 6  alkyl); (C 1 -C 6  alkyl)-3-7 membered saturated, partially saturated, or unsaturated carbocycle; and (C 1 -C 6  alkyl)-3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; \n R a3  is selected from hydrogen, halogen, OH, O(C 1 -C 6  alkyl), and C 1 -C 6  alkyl; \n R a4  is selected from hydrogen, halogen, and C 1 -C 6  alkyl; \n Z 11  is selected from CR 11 , N, and N\u2014O; \n Z 12  is selected from CR 12 , N, and N\u2014O; \n Z 13  is selected from CR 13 , N, and N\u2014O; \n Z 15  is selected from CR 15 , N, and N\u2014O; \n R 11 , R 12 , R 13 , R 14 , and R 15  are independently selected from hydrogen, halogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, (C 1 -C 6  alkyl)-OR 40 , OH, O(C 1 -C 6  alkyl), OCF 3 , OCF 2 H, OCFH 2 , CN, N 3 , NO 2 , NH 2 , NH(C 1 -C 6  alkyl), N(C 1 -C 6  alkyl) 2 , NR 40 C(O)R 40 , C(O)NR 40 R 40 , COH, CO(C 1 -C 6  alkyl), S(O) t R 40 , NR 40 S(O) t R 40 , S(O) t NR 40 R 40 , SR 40 , SCF 3 , COOR 40 , COR 40 , and OR 40 ; 3-7 membered saturated, partially saturated, or unsaturated carbocycle; and 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur;\n alternatively, two substituents selected from R 11 , R 12 , R 13 , R 14 , and R 15  on two adjacent carbon atoms taken together form a 3-7 membered saturated, partially saturated, or unsaturated carbocycle; or a 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; where the carbocycle or heterocycle is optionally substituted with one or more R 40 ; \n \n R 40  is independently selected from hydrogen; halogen; C 1 -C 6  alkyl; C 2 -C 6  alkenyl, C 2 -C 6  alkynyl; 3-7 membered saturated, partially saturated, or unsaturated carbocycle; 3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; (C 1 -C 6  alkyl)-3-7 membered saturated, partially saturated, or unsaturated carbocycle; and (C 1 -C 6  alkyl)-3-7 membered saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; \n or two R 40  taken together with the carbon atom to which they are attached form a carbonyl; \n j is 0, 1, or 2; \n p is 0, 1, or 2; \n q is 0, 1, or 2; and \n t is 0, 1, or 2.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 90.0
- Lexical Diversity: 1.21739
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14112027', '14774071', '15495670', '13021336', '13683296']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7978723406911667
- 35 USC 102 Novelty (BERT): 0.5392305495106158
- Combined Prediction Score: 0.7720081615731116
- Mean Citation Score: 341.09327
- Max Citation Score: 370.0367
- Similarity Product: 310.6650681613803

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test