PATENT CLAIM ANALYSIS

Application Number: 16129199
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "254050"]

Abstract:
The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Claim (Index 1):
A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein:\n X is CH or N; \n R is H, halo, \u2014OH, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl or C 1-4  haloalkoxy; \n R 1  is H, C 1-4 alkyl, C 1-4 haloalkyl, or 3-6 membered cycloalkyl; \n R 2  and R 3  are each, independently, H or C 1-4 alkyl; \n R 4  is halo, \u2014C\u2261C\u2014R 6 , \u2014C 6 H 4 \u2014R 6 , -(4-10 membered heterocyclyl)-R 6 , a 5-10 membered heteroaryl optionally substituted with 1-3 R 6  groups, -(4-10 membered carbocyclyl)-R 6 , a 6-10 membered fused heterocyclyl-aryl optionally substituted with 1-3 C 1-4 alkyl groups, or a 6-10 membered fused heterocyclyl-heteroaryl optionally substituted with 1-3 C 1-4 alkyl groups; \n R 5  is H, or R 4  and R 5  together with the carbon atoms to which they are attached form a 5-12 membered carbocyclic, heterocyclic, aryl, heteroaryl, fused heterocyclyl-aryl, fused heterocyclyl-heteroaryl, fused carbocyclyl-aryl, or fused carbocyclyl-heteroaryl ring, wherein said carbocyclic, heterocyclic, aryl, heteroaryl, fused heterocyclyl-aryl, fused heterocyclyl-heteroaryl, fused carbocyclyl-aryl, or fused carbocyclyl-heteroaryl ring is optionally substituted with 1-3 C 1-4 alkyl groups; \n each R 6  is independently \u2014(CH 2 ) m \u2014(CO) n \u2014(CH 2 ) p \u2014R 6a , \u2014O\u2014R 6a , \u2014(CH 2 ) m \u2014(CO) n \u2014(CH 2 ) p \u2014R 6b , \u2014O\u2014R 6b , \u2014(CH 2 ) m \u2014(CO) n \u2014(CH 2 ) p \u2014R 6c , \u2014O\u2014R 6c , \u2014(CH 2 ) m \u2014(CO) n \u2014(CH 2 ) p \u2014R 6d , or \u2014O\u2014R 6d ; \n R 6a  is H, \u2014OH, \u2014NR 7 R 8 , \u2014CN, oxo, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, \u2014CH(NR 7 R 8 )\u2014C 1-3 haloalkyl, \u2014CH(NR 7 R 8 )\u2014C 1-3 alkyl, \u2014C(CH 3 )(NR 7 R 8 )\u2014C 1-3 alkyl, \u2014SO 2 C 1-4 alkyl, \u2014SO 2 C 1-4 hydroxyalkyl, or \u2014SO 2 NR 7 R 8 ; \n R 6b  is a 4-10 membered heterocyclyl optionally substituted with 1-3 substituents independently selected from a group consisting of halo, \u2014OH, \u2014NR 7 R 8 , C 1-4 alkyl, \u2014C 1-4 haloalkyl, \u2014C 1-4 hydroxyalkyl, \u2014C 1-4 alkyl-NR 7 R 8 , \u2014SO 2 C 1-4 alkyl, and 4-6 membered heterocyclyl; \n R 6c  is a 5-10 membered heteroaryl optionally substituted with 1-3 substituents independently selected from a group consisting of \u2014NR 7 R 8 , C 1-4 alkyl, \u2014C 1-4 hydroxyalkyl, and \u2014C 1-4 alkyl-NR 7 R 8 ; \n R 6d  is a 4-10 membered carbocyclyl optionally substituted with 1-3 substituents independently selected from a group consisting of halo, \u2014OH, \u2014NR 7 R 8 , C 1-4 alkyl, \u2014C 1-4 haloalkyl, \u2014C 1-4 hydroxyalkyl, \u2014C 1-4 alkyl-NR 7 R 8 , \u2014SO 2 C 1-4 alkyl, and 4-6 membered heterocyclyl; \n R 7  and R 8  are each, independently, selected from a group consisting of H, C 1-4 alkyl, C 1-4 hydroxyalkyl, a 4-6 membered heterocyclyl, and a 4-6 membered cycloalkyl; \n m is 0 or 1; \n n is 0 or 1; and \n p is 0 or 1.

Metadata:
- Claim Count in Document: 18.0
- Percentile: 97.0
- Lexical Diversity: 1.45763
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16045993', '14774839', '14774844', '12994250', '15890436']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7964665622069116
- 35 USC 102 Novelty (BERT): 0.5710158800636179
- Combined Prediction Score: 0.7739214939925823
- Mean Citation Score: 340.874326
- Max Citation Score: 451.14423
- Similarity Product: 387.4449745785338

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test