PATENT CLAIM ANALYSIS

Application Number: 16159185
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["435", "375000"]

Abstract:
Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in the membranes of cells and introduce material into the cells. The material includes for example one selected from the group of: an inorganic compound, a drug, a genetic material, a protein, a carbohydrate, a synthetic polymer, and a pharmaceutical composition.

Claim (Index 38):
A method of introducing a composition in a fluid into cells, the method comprising:\n a. passaging a suspension of cells in a fluid with the composition through a decrease in pressure, wherein the passaging occurs by the application of a positive pressure; and b. drawing the suspension of cell back through the at least one constriction by the application of a negative pressure, wherein the decrease in pressure occurs in a device comprising a channel with at least one constriction, wherein the positive pressure and a negative pressure are generated by a flow device and wherein the decrease in pressure enhances temporary permeability in the cells, thereby introducing the composition into the cells.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 97.0
- Lexical Diversity: 1.85714
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13231592', '15526517', '14352354', '12443153', '14916679']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.491071672299855
- 35 USC 102 Novelty (BERT): 0.5656340938811071
- Combined Prediction Score: 0.4985279144579803
- Mean Citation Score: 249.96745
- Max Citation Score: 471.56735
- Similarity Product: 344.72326861116585

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test