PATENT CLAIM ANALYSIS

Application Number: 15909447
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["506", "009000"]

Abstract:
A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.

Claim (Index 3):
A method of identifying a compound of interest in a library of compounds, each of said compounds being bound to its respective solid support and produced by a unique reaction series composed of N reaction steps, wherein N is an integer from at least 1 to about 100, and wherein each compound is produced from components which are independently the same or different, said method comprising:\n (a) dividing a population of solid supports having at least one type of a functional group at the surface of said solid support selected from the group consisting of CO 2 H, OH, SH, NH 2 , NHR, CH 2 Cl, CH 2 Br and CHN 2 , wherein R is a linear C 1 -C 9  alkyl group, into M batches, wherein M is an integer from at least 2 to about 25; (b) reacting each of the M batches of solid support with a component, so that the component forms a bond with the solid support via the functional group, the component being independently protected or unprotected; (c) adding to each batch, prior to coupling step b), concurrently therewith, or subsequently to step b), from about 0.001 to about 0.5 molar equivalent of a spectrally distinguishable fluorophore tag uniquely associated with each component and capable of forming a bond to the solid support or to the component, wherein said fluorophore tag represents a bit of binary code and comprises zero, one, or more than one fluorescent dye(s), said dye(s) being spectrally distinguishable by excitation wavelength, emission wavelength, excited-state lifetime or emission intensity; (d) recombining all of said M batches after the coupling and the tagging step; (e) repeating steps (a) to (d) for N-1 times, or repeating steps (a) to (d) for N-2 times followed by repeating steps (a) to (c) once, to produce a library of compounds; (f) performing an assay capable of indicating that any compound in the library has a property of interest; and (g) identifying the compound having the property of interest by optically interrogating the fluorophore tag(s) bound to the solid support on which the compound having the property of interest was produced, said optical interrogation being carried out without isolating the solid support of interest from other solid supports.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 90.0
- Lexical Diversity: 1.32075
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14607496', '09448420', '10529397', '12555707', '11584880']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5514320490395861
- 35 USC 102 Novelty (BERT): 0.5721169579151995
- Combined Prediction Score: 0.5535005399271474
- Mean Citation Score: 294.545102
- Max Citation Score: 452.4951
- Similarity Product: 389.3612892424821

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test