PATENT CLAIM ANALYSIS

Application Number: 15979932
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["544", "060000"]

Abstract:
The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

Claim (Index 27):
The compound according to  claim 1 , wherein\n R 1  means \u2014H or \u2014CH 3 ; R 2  means \u2014C 1 -C 6 -alkyl, linear or branched, saturated, unsubstituted; R 3  means -phenyl, -thienyl or -pyridinyl, in each case unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014CN, \u2014CH 3 , \u2014CH 2 CH 3 , \u2014CH 2 F, \u2014CHF 2 , \u2014CF 3 , \u2014OCF 3 , \u2014OH, \u2014OCH 3 , \u2014C(\u2550O)NH 2 , C(\u2550O)NHCH 3 , \u2014C(\u2550O)N(CH 3 ) 2 , \u2014NH 2 , \u2014NHCH 3 , \u2014N(CH 3 ) 2 , \u2014NHC(\u2550O)CH 3 , \u2014CH 2 OH, \u2014SOCH 3  and \u2014SO 2 CH 3 ; R 4  means \u2014H; \u2014C 1 -C 6 -alkyl, linear or branched, saturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014OH, and \u2014O\u2014C 1 -C 4 -alkyl; 3-6-membered cycloalkyl, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014OH, and \u2014O\u2014C 1 -C 4 -alkyl, wherein said 3-6-membered cycloalkyl is connected through \u2014C 1 -C 6 -alkylene; or 3-6-membered heterocycloalkyl, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014OH, and \u2014O\u2014C 1 -C 4 -alkyl, wherein said 3-6-membered heterocycloalkyl is connected through \u2014C 1 -C 6 -alkylene; X means \u2014O\u2014 or \u2014NR 6 \u2014; R 5  means \u2014H; \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014O\u2014C 1 -C 4 -alkyl, \u2014C(\u2550O)OH, \u2014C(\u2550O)OC 1 -C 4 -alkyl, \u2014C(\u2550O)NH 2 , \u2014C(\u2550O)NHC 1 -C 4 -alkyl, \u2014C(\u2550O)N(C 1 -C 4 -alkyl) 2 , \u2014OH, \u2014S(\u2550O)C 1 -C 4 -alkyl and \u2014S(\u2550O) 2  C 1 -C 4 -alkyl; -cyclobutyl, unsubstituted or monosubstituted with \u2014OH; wherein said -cyclobutyl is connected through \u2014CH 2 \u2014; -heterocyclobutyl, unsubstituted; or -oxazolyl, -pyridinyl, -pyridazinyl or -pyrimidinyl, in each case unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, Br, \u2014I, \u2014OH, \u2014O\u2014C 1 -C 4 -alkyl, \u2014CN, and \u2014S(\u2550O) 2 C 1 -C 4 -alkyl; wherein said -oxazolyl, -pyridinyl, -pyridazinyl or -pyrimidinyl is optionally connected through \u2014CH 2 \u2014; in case X means NR 6 , R 6  means \u2014H or \u2014CH 3 ; or in case X means NR 6 , R 5  and R\u2032 together with the nitrogen atom to which they are attached form a piperidine moiety, a pyrrolidine moiety, a morpholine moiety, a thiomorpholine moiety, a thiomorpholine dioxide moiety, or a piperazine moiety, in each case unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2550O, \u2014OH, and \u2014C(\u2550O)NH 2 ; wherein said piperidine moiety, pyrrolidine moiety, morpholine moiety, thiomorpholine moiety, thiomorpholine dioxide moiety, or piperazine moiety is optionally condensed with an imidazole moiety, unsubstituted; R 7  and R 8  independently of one another mean \u2014H or \u2014CH 3 ; or R 7  and R 8  together with the carbon atom to which they are attached form a ring selected from the group consisting of cyclopropyl, cyclobutyl, heterocyclobutyl and heterocyclohexyl, in each case unsubstituted; and R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , and R 20  mean \u2014H.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 1.11111
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12699451', '15326138', '12700857', '11994001', '12604691']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.84409069699864
- 35 USC 102 Novelty (BERT): 0.5468638986468863
- Combined Prediction Score: 0.8143680171634647
- Mean Citation Score: 384.19599200000016
- Max Citation Score: 420.33426
- Similarity Product: 357.5996094061589

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test