PATENT CLAIM ANALYSIS

Application Number: 16362551
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["424", "093210"]

Abstract:
The present disclosure provides compositions and methods for targeting a minor histocompatibility (H) antigen (HA-1 H ) to, for example, prevent or manage relapse of a hematological malignancy after allogeneic hematopoietic stem cell transplantation (HCT). Also provided are transgene constructs encoding engineered binding proteins, such as a T cell receptor or a chimeric antigen receptor, optionally encoding additional components such as a co-receptor and/or safety switch. Such transgene constructs can be transduced into an immune cell, such as a T cell, and used as an immunotherapy in a subject having a hematological malignancy or at risk for recurrence of the hematological malignancy (e.g., leukemia, lymphoma, myeloma).

Claim (Index 5):
The engineered immune cell of  claim 1 , wherein:\n (a) the encoded V\u03b2 CDR3 comprises the amino acid sequence of SEQ ID NO: 14, and the encoded V\u03b1 CDR3 comprises the amino acid sequence of SEQ ID NO: 88; (b) the encoded V\u03b2 CDR3 comprises the amino acid sequence of SEQ ID NO: 13, and the encoded V\u03b1 CDR3 comprises the amino acid sequence of SEQ ID NO: 87; (c) the encoded V\u03b2 CDR3 comprises the amino acid sequence of SEQ ID NO: 15, and the encoded V\u03b1 CDR3 comprises the amino acid sequence of SEQ ID NO: 89; (d) the encoded V\u03b2 CDR3 comprises the amino acid sequence of SEQ ID NO: 16, and the encoded V\u03b1 CDR3 comprises the amino acid sequence of SEQ ID NO: 90; (e) the encoded V\u03b2 CDR3 comprises the amino acid sequence of SEQ ID NO: 17, and the encoded V\u03b1 CDR3 comprises the amino acid sequence of SEQ ID NO: 91; or (f) the encoded V\u03b2 CDR3 comprises the amino acid sequence of SEQ ID NO: 86, and the encoded V\u03b1 CDR3 comprises the amino acid sequence of SEQ ID NO: 92.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 99.0
- Lexical Diversity: 1.64474
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14813782', '15006224', '13500123', '14830392', '15301686']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7129861709232829
- 35 USC 102 Novelty (BERT): 0.5400277762971701
- Combined Prediction Score: 0.6956903314606716
- Mean Citation Score: 297.5274
- Max Citation Score: 362.96222
- Similarity Product: 271.73699325144173

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test