PATENT CLAIM ANALYSIS

Application Number: 15871039
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-11
Patent Classification: ["435", "135000"]

Abstract:
The present disclosure relates to the technical field of biochemical engineering and particularly discloses a preparation method for (R)-3-hydroxyl-5-hexenoate. In the method of the present disclosure, the (R)-3-hydroxyl-5-hexenoate is prepared by catalytic reduction of 3-carbonyl-5-hexenoate by ketoreductase with 3-carbonyl-5-hexenoate as the substrate. The amino acid sequence of ketoreductase is shown in SEQ ID NO.1. In the present disclosure, the (R)-3-hydroxyl-5-hexenoate having a very high chiral purity is obtained by asymmetric reduction by ketoreductase as the biocatalyst. The present disclosure has the advantages of easy operation, mild reaction conditions, high reaction yield and good practical industrial application value.

Claim (Index 1):
A preparation method for (R)-3-hydroxyl-5-hexenoate, characterized in that a chemical formula (I) of the (R)-3-hydroxyl-5-hexenoate is wherein R is alkyl or cycloalkyl having 1 to 8 carbon atoms, or mono- or poly-substituted aryl or aralkyl, wherein (R)-3-hydroxyl-5-hexenoate (I) is prepared by asymmetric reduction of 3-carbonyl-5-hexenoate (II) by ketoreductase as catalyst.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 86.0
- Lexical Diversity: 1.79688
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12978022', '14742215', '13577772', '15627652', '15184242']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5789775572884845
- 35 USC 102 Novelty (BERT): 0.476635109812689
- Combined Prediction Score: 0.5687433125409049
- Mean Citation Score: 189.389526
- Max Citation Score: 192.06104
- Similarity Product: 155.45581268929004

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test