PATENT CLAIM ANALYSIS

Application Number: 15942333
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "211080"]

Abstract:
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Claim (Index 16):
The compound of  claim 15 , wherein R 4  is: wherein, v is 0, 1, 2 or 3; and R 5  is selected from the group consisting of C 1-6  alkyl, C 3-7  cycloalkyl, C 2-6  alkenyl, C 2-6  alkenylene, halogen, cyano, hydroxyl, C 1-6  alkoxy, optionally substituted C 2-9  heteroaryl, \u2014SO 2 R e , \u2014NR e R f , \u2014NR e C(O)R f , \u2014NReSO 2 R f  and NR e R f \u2014C(O)\u2014; wherein the C 1-6  alkyl, C 3-7  cycloalkyl, C 2-6  alkenyl, C 2-6  alkenylene of R 5  can be optionally substituted with one to four substituents independently selected from the group consisting of C 1-6  alkoxy, hydroxyl, halogen, cyano, \u2014SO 2 R e , \u2014NR e R f \u2014NR e C(O)R f  and \u2014C(O)NR e R f , wherein R e  and R f  in each occurrence are independently selected from the group consisting of hydrogen, branched or linear C 1-6  alkyl and C 3-7  cycloalkyl.

Metadata:
- Claim Count in Document: 104.0
- Percentile: 90.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15942321', '15698788', '13266976', '15852639', '14428546']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8070762772854304
- 35 USC 102 Novelty (BERT): 0.530965680145913
- Combined Prediction Score: 0.7794652175714787
- Mean Citation Score: 281.45004400000005
- Max Citation Score: 362.283
- Similarity Product: 276.24056724375487

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test