PATENT CLAIM ANALYSIS

Application Number: 15772276
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "631000"]

Abstract:
Provided are methods for using S-alkylisothiouronium derivatives, including S-ethylisothiouronium diethylphosphate, to alleviate, prevent and/or reduce a sequela of intra-dialytic hypotension.

Claim (Index 33):
A method for preventing and/or reducing a sequela of intra-dialytic hypotension, comprising administering to a subject a therapeutically effective amount of a compound having the general formula I: wherein,\n R 1  is a linear or branched saturated or unsaturated alkylene, comprising one to eight carbon atoms optionally substituted with one or more substituent selected from the group consisting of halogen, primary, secondary, tertiary or quaternary amine, primary, secondary or tertiary alcohol, or interrupted by one or more heteroatom selected from the group consisting of O, N, and S; \n R 2 , R 3 , R 4  and R 5  are each independently a hydrogen, hydroxy, linear or branched lower alkyl, linear or branched lower alkenyl, linear or branched lower alkynyl, lower alkoxy, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, lower thioalkoxy, nitro, amino, cyano, sulfonyl, haloalkyl, carboaryloxy, carboalkylaryloxy, alkyl sulfoxide, aryl sulfoxide, alkyl sulfone, aryl sulfone, alkyl sulfate, aryl sulfate, sulfonamide, thioalkyl, optionally substituted by halogen; \n A \u2212  is a physiologically acceptable anion; \n and a pharmaceutically acceptable carrier or diluent; \n wherein the sequela of hypotension is selected from the group consisting of vascular access dysfunction, vascular access closure, vascular access thrombosis, drug induced hypertension and any combination thereof.

Metadata:
- Claim Count in Document: 86.0
- Percentile: 91.0
- Lexical Diversity: 1.09091
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11550548', '10382217', '13667227', '10940473', '13415569']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7432856320351936
- 35 USC 102 Novelty (BERT): 0.4755419397550193
- Combined Prediction Score: 0.7165112628071763
- Mean Citation Score: 196.232472
- Max Citation Score: 232.80682
- Similarity Product: 210.9438809483337

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test