PATENT CLAIM ANALYSIS

Application Number: 15869672
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "021900"]

Abstract:
Embodiments of this invention provide compositions and methods for therapeutic use of diketopiperazines including cyclic G-2-Allyl Proline and other cyclic Glycyl Proline compounds to treat symptoms of Autism Spectrum Disorders and Neurodevelopmental Disorders as well as manufacture of medicaments including tablets, capsules, liquid formulations, gels, injectable solutions, and other formulations that are useful for treatment of such conditions.

Claim (Index 8):
A method for treating a symptom of an Autism Spectrum Disorder (ASD) or Neurodevelopmental Disorder (NDD) selected from the group consisting of Fragile X Syndrome (FXS), and Rett Syndrome, in a mammal suffering from such a disorder, comprising administering to the mammal, a compound having the formula: or a pharmaceutically acceptable salt or hydrate thereof, wherein\n X 1  is selected from the group consisting of NR\u2032, O and S; \n X 2  is selected from the group consisting of CH 2 , NR\u2032, O and S; \n R 1 , R 2 , R 3 , R 4  and R 5  are independently selected from the group consisting of \u2014H, \u2014OR\u2032, \u2014SR\u2032, \u2014NR\u2032R\u2032, \u2014NO 2 , \u2014CN, \u2014C(O)R\u2032, \u2014C(O)OR\u2032, \u2014C(O)NR\u2032R\u2032, \u2014C(NR\u2032)NR\u2032R\u2032, trihalomethyl, halogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl and substituted heteroarylalkyl; each R\u2032 is independently selected from the group consisting of \u2014H, alkyl, heteroalkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl; \n or R 4  and R 5  taken together are \u2014CH 2 \u2014(CH 2 ) n \u2014CH 2 \u2014 where n is an integer from 0-6; \n or R 2  and R 3  taken together are \u2014CH 2 \u2014(CH 2 ) n \u2014CH 2 \u2014 where n is an integer from 0-6; \n with the proviso that when R1=methyl and R2\u2550R 3 \u2550R 4 \u2550H then R 5 \u2260benzyl and; \n when R 1 \u2550H, at least one of R 2  and R 3 \u2260H.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 86.0
- Lexical Diversity: 1.42222
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15004218', '13699087', '14605420', '13043215', '14314802']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7979189359219493
- 35 USC 102 Novelty (BERT): 0.663125721331123
- Combined Prediction Score: 0.7844396144628666
- Mean Citation Score: 470.835938
- Max Citation Score: 816.6358
- Similarity Product: 608.6802749825239

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test