PATENT CLAIM ANALYSIS

Application Number: 15882221
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
The invention refers to an oligonucleotide consisting of 10 to 20 nucleotides of selected regions of the TGF-beta1, TGF-beta2 or TGF-beta3 nucleic acid sequence, which comprises modified nucleotides such as LNA, ENA, polyalkylene oxide-, 2′-fluoro, 2′-O-methoxy and/or 2′-O-methyl modified nucleotides. The selected regions are preferably the region of nucleic acid no. 1380 to 1510, no. 1660 to 1680, no. 2390 to 2410, or no. 2740 to 2810 of the TGF-beta2 nucleic acid sequence of SEQ ID NO. 1, specific regions of the TGF-beta1 nucleic acid sequence of SEQ ID NO. 149, or specific regions of the TGF-beta3 nucleic acid sequence of SEQ ID No. 267. The invention further relates to pharmaceutical compositions comprising such oligonucleotide, wherein the composition or the oligonucleotide is used in the prevention and/or treatment of a malignant and/or benign tumor, an immunologic disease, fibrosis, glaucoma, etc.

Claim (Index 6):
A method of inhibiting and/or treating a malignant and/or a benign tumor, fibrosis, cirrhosis, scleroderma or a related dermatologic disease, or a CNS disease comprising administering a pharmaceutical composition to a subject in need thereof, the pharmaceutical composition comprising an oligonucleotide consisting of 12 to 18 nucleotides hybridizing with a TGF-beta1, TGF-beta3 or/and TGF-beta2 nucleic acid, wherein one or more nucleotide(s) of the oligonucleotide is/are LNA modified, wherein the modified nucleotide is a LNA, and/or an ENA, polyalkylene oxide-, 2\u2032-fluoro-, 2\u2032-O-methoxy-, and/or 2\u2032O-methyl-modified nucleotide and a pharmaceutically acceptable carrier.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 2.15584
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14780043', '15593764', '14779930', '14779945', '11792041']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8807251909937232
- 35 USC 102 Novelty (BERT): 0.7189040984260625
- Combined Prediction Score: 0.864543081736957
- Mean Citation Score: 741.030704
- Max Citation Score: 900.2504
- Similarity Product: 769.6749380240442

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test