PATENT CLAIM ANALYSIS

Application Number: 15948359
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "167000"]

Abstract:
Disclosed is a compound of Formula (I) in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, and a are defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are a pharmaceutical composition comprising a compound or salt thereof of Formula (I) and a method of treating a disease which benefits from the modulation of the vitamin D receptor, such as a bone disorder, cardiovascular disease, a cardiovascular complication associated with renal disease, endothelial dysfunction, hyperparathyroidism, hypocalcemia, an immune disorder, left ventricular hypertrophy, a proliferative disease, proteinuria, renal disease, and thrombosis.

Claim (Index 12):
The compound or a pharmaceutically acceptable salt thereof of  claim 1  wherein the compound is selected from the group consisting of\n (1R, 3R)-5-((E)-2-((3\u03b1S, 7\u03b1S)-1-((R)-1-((S)-3-hydroxy-2,3-dimethylbutoxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H, 5H, 6H, 7H, 7\u03b1H)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol (Vida-5); \n (4R,8R)-6-((E)-2-((1S,7S)-1-((R)-1-(3-ethyl-3-hydroxypentyloxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H, 5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-10); \n (4R, 8R)-6-((E)-2-((1S, 7\u03b1S)-1-((R)-1-(4-ethyl-4-hydroxyhexyloxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-20); \n (1R, 3R)-5-((E)-2-((1S, 3\u03b1S, 7\u03b1S)-1-((R)-1-(3-ethyl-3-hydroxypentyloxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H, 5H, 6H, 7H, 7\u03b1H)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol (Vida-11); \n (1R, 3R)-5-((E)-2-((1S, 7\u03b1S)-1-((R)-1-(4-ethyl-4-hydroxyhexyloxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H, 5H, 6H, 7H, 7a/H)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol (Vida-21); \n (4R,8R)-6-((E)-2-((1S, 7\u03b1S)-1-((R)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-1); \n (4R,8R)-6-((E)-2-((3\u03b1S, 7\u03b1S)-1-((R)-1-((S)-3-hydroxy-2,3-dimethylbutoxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H, 5H, 6H, 7H, 7\u03b1H)-lidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-4); \n (4R,8R)-6-((E)-2-(1-((R)-1-(3-(2-hydroxypropan-2-yl)phenoxy)propan-2-yl)-7\u03b1-methydihydro-1H-inden-4(2H,5H, 6H,7H,7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-57); \n (4R, 8R)-6-((E)-2-(1-((R)-1-(3-(2-hydroxypropan-2-yl)phenylthio)propan-2-yl)-7\u03b1-methyldihydro-1H-inden-4(2H, 5H, 6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-58); \n (1R,3R)-5-((E)-2-(1-((R)-1-(3-(2-hydroxypropan-2-yl)phenoxy)propan-2-yl)-7\u03b1-methyldihydro-1H-inden-4(2H, 5H, 6H, 7H, 7\u03b1H)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol (Vida-37); \n (1R,3R)-5-((E)-2-(1-((R)-1-(3-(2-hydroxypropan-2-yl)phenythio)propan-2-yl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H, 6H, 7H, 7\u03b1H)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol (Vida-43); \n (4R, 8R)-6-((E)-2-((1S, 7\u03b1S)-1-((R)-1-(3-methylbutoxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-81); \n (4R, 8R)-6-((E)-2-((3\u03b1S, 7\u03b1S)-1-((R)-1-((S)-2,3-dimethylbutoxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-84); \n (1R,3R)-5-((E)-2-((3\u03b1S, 7\u03b1S)-1-((R)-1-((S)-2,3-dimethylbutoxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H, 5H, 6H, 7H, 7\u03b1H)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol (Vida-85); \n (4R, 8R)-6-((E)-2-((1S, 7\u03b1S)-1-((R)-1-(3-ethyl-pentyloxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-90); \n (1R, 3R)-5-((E)-2-((1S, 3\u03b1S, 7\u03b1S)-1-((R)-1-(3-ethyl-pentyloxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol (Vida-91); \n (4R, 8R)-6-((E)-2-((1S, 7\u03b1S)-1-((R)-1-(4-ethyl-hexyloxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-100); \n (1R,3R)-5-((E)-2-((1S, 7\u03b1S)-1-((R)-1-(4-ethyl-hexyloxy)ethyl)-7\u03b1-methyldihydro-1H-inden-4(2H, 5H, 6H, 7H, 7\u03b1H)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol (Vida-101); \n (1R,3R)-5-((E)-2-(1-((R)-1-(3-isopropylphenoxy)propan-2-yl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)-2-methylenecyclohexane-,3-diol (Vida-117); \n (1R, 3R)-5-((E)-2-(1-((R)-1-(3-isopropylphenylthio)propan-2-yl)-7\u03b1-methyldihydro-1-H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)-2-methylenecyclohexane-1,3-diol (Vida-123) (4R, 8R)-6-((E)-2-(1-((R)-1-(3-isopropylphenoxy)propan-2-yl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-137); and \n (4R,8R)-6-((E)-2-(1-((R)-1-(3-isopropylphenylthio)propan-2-yl)-7\u03b1-methyldihydro-1H-inden-4(2H,5H,6H, 7H, 7\u03b1H)-ylidene)ethylidene)spiro[2.5]octane-4,8-diol (Vida-138).

Metadata:
- Claim Count in Document: 35.0
- Percentile: 91.0
- Lexical Diversity: 1.86364
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13521980', '15537292', '13404958', '13102705', '11404267']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7729663356594915
- 35 USC 102 Novelty (BERT): 0.5081310760288339
- Combined Prediction Score: 0.7464828096964257
- Mean Citation Score: 257.772788
- Max Citation Score: 264.4791
- Similarity Product: 197.578209741962

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test