PATENT CLAIM ANALYSIS

Application Number: 16356360
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-09
Patent Classification: ["514", "252030"]

Abstract:
Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

Claim (Index 1):
A compound represented by a formula: or a pharmaceutically acceptable salt thereof; wherein X is S; Ring A is an optionally substituted aryl having 6-10 ring carbon atoms, heteroaryl having 1-9 ring carbon atoms, or bicyclic ring system having 7-10 ring carbon atoms; Ring B is: \u2003and wherein R A  and R B  are independently H or C 1-6  hydrocarbyl, or \u2014N(R A )(R B ) is an optionally substituted heterocyclic ring system, wherein the heterocyclic ring system is a mono-cyclic ring having 2-8 ring carbon atoms, 1-2 ring nitrogen atoms, 0-1 ring oxygen atom, and 0-1 ring sulfur atom; a bicyclic ring system having 5-12 ring carbon atoms, 1-2 ring nitrogen atoms, 0-1 ring oxygen atom, and 0-1 ring sulfur atom, or a tricyclic ring system having 8-16 ring carbon atoms, 1-2 ring nitrogen atoms, 0-1 ring oxygen atom, and 0-1 ring sulfur atom; and wherein the bicyclic ring system can be Spiro, fused, or bridged.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 99.0
- Lexical Diversity: 1.58333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15736989', '16228324', '15110511', '15899821', '15736925']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7953263867127204
- 35 USC 102 Novelty (BERT): 0.5122084981972396
- Combined Prediction Score: 0.7670145978611723
- Mean Citation Score: 288.909928
- Max Citation Score: 300.6652200000001
- Similarity Product: 237.96776784534225

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test