PATENT CLAIM ANALYSIS

Application Number: 15974536
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "232800"]

Abstract:
The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.

Claim (Index 1):
A method of using an intermediate compound for the preparation of a compound of general formula (Ib): in which: R 1  represents wherein * indicates the point of attachment of said group with the rest of the molecule; R 2  represents hydrogen, halogen, \u2014NR 7 R 8 , CN, C 1 -C 6 -alkyl, C 1 -C 4 -alkoxy, 3- to 10-membered heterocycloalkoxy, C 2 -C 4 -alkenyl, C 3 -C 6 -cycloalkyl, 3- to 10-membered heterocycloalkyl, 4- to 10-membered heterocycloalkenyl, phenyl, heteroaryl, \u2014(CO)NR 7 R 8 , \u2014(SO 2 )R 9 , \u2014(SO)R 9 , \u2014SR 9 , \u2014N\u2550(SO)R 9 R 10 , \u2014(PO)(OR 7 ) 2 , \u2014(PO)(OR 7 )R 10  or \u2014(PO)(R 10 ) 2 ;\n wherein each C 1 -C 6 -alkyl, C 1 -C 4 -alkoxy, C 3 -C 6 -cycloalkyl, 3- to 10-membered heterocycloalkyl, phenyl or heteroaryl is optionally substituted, one or more times, independently from each other, with halogen, OH, amino, \u2014NR 7 R 8 , C 1 -C 4 -alkyl optionally substituted with hydroxyl or phenyl, C 1 -C 2 -haloalkyl, C 1 -C 3 -alkoxy, C 3 -C 6 -cycloalkyl, 3- to 6-membered heterocycloalkyl, phenyl, \u2014(CO)OR 7 , \u2014(CO)NR 7 R 8 , \u2014NR 7 (CO)R 10 , \u2014NR 8 (CO)OR 7 , \u2014(SO 2 )R 9 , \u2014SR 9 , \u2014NR 7 (SO 2 )R 9 , \u2014((SO)\u2550NR 11 )R 10 , \u2014(PO)(OR 7 ) 2 , \u2014(PO)(OR 7 )R 10  or a heteroaryl group; \n wherein each 4- to 10-membered heterocycloalkenyl is optionally substituted, one or more times, independently from each other, with methyl; \n R 4  represents hydrogen or methyl; R 7 , R 8  represent, independently from each other, hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl or phenyl, wherein phenyl is optionally substituted, one or more times, with halogen; R 9  represents C 1 -C 4 -alkyl or phenyl, wherein each C 1 -C 4 -alkyl or phenyl is optionally substituted, one or more times, independently from each other, with R 33 ; R 10  represents C 1 -C 4 -alkyl; or R 9  and R 10  together, in case of \u2014N\u2550(SO)R 9 R 10  group, represent a 5- to 8-membered heterocycloalkyl group; R 11  represents hydrogen, C 1 -C 4 -alkyl, \u2014(CO)OR 7 , \u2014(CO)NR 7 R 8  or CN; R 13  represents halogen, OH or C 1 -C 6 -alkoxy; wherein the intermediate compound is selected from the group consisting of: in which R 3  represents hydrogen; X represents chloro, bromo or iodo; and Y represents OH, \u2014O\u2014SO 2 \u2014CF 3 , Cl, Br, I, SH or \u2014SO 2 Cl.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 93.0
- Lexical Diversity: 1.72
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15159548', '15501079', '12729940', '13054853', '13970854']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8078321277987053
- 35 USC 102 Novelty (BERT): 0.5889734795238099
- Combined Prediction Score: 0.7859462629712157
- Mean Citation Score: 384.060128
- Max Citation Score: 492.7248
- Similarity Product: 437.1686427886963

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test