PATENT CLAIM ANALYSIS

Application Number: 15989008
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["544", "242000"]

Abstract:
Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or I′ structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I or I′ compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Claim (Index 43):
The method of  claim 42 , wherein the additional therapeutic agent is a corticosteroid which is dexamethasone, a proteasome inhibitor selected from the group consisting of carfilzomib, ixazomib and bortezomib; an IMiD selected from the group consisting of lenalidomide and pomalidomide; an antibody selected from the group consisting of an anti-CD38 antibody, an anti-VEGF-A antibody, an anti-PD-1 antibody, an anti-PD-L1 antibody and an anti-interleukin-6 antibody; or a combination thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.46154
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14748990', '15187854', '14670088', '13637127', '16312061']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8281165615176068
- 35 USC 102 Novelty (BERT): 0.5192154602399016
- Combined Prediction Score: 0.7972264513898363
- Mean Citation Score: 324.014682
- Max Citation Score: 328.42313
- Similarity Product: 202.5123696701741

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test