PATENT CLAIM ANALYSIS

Application Number: 15892965
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["548", "190000"]

Abstract:
Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-hetereoaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like.

Claim (Index 13):
The compound of  claim 1 , having the formula (XXXIII) or formula (XXXIV): wherein: R 2  is an alkoxy (e.g., methoxy) or a substituted alkoxy; R 3  is hydrogen, a lower alkyl (e.g., methyl) or a substituted lower alkyl; R 1  is an aryl, a substituted aryl, (e.g., a substituted phenyl), a cycloalkyl, a substituted cycloalkyl (e.g., a substituted cyclohexyl), a heterocycle (e.g., a tetrahydropyran or a piperidinyl) or a substituted heterocycle; and R 4  is selected from cycloalkyl, substituted cycloalkyl, alkyl-cycloalkyl, substituted alkyl-cycloalkyl, heterocycle, substituted heterocycle, alkyl-heterocycle (e.g., \u2014CH 2 -(4-tetrahydropyran)) and substituted alkyl-heterocycle.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.72222
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15055403', '13718632', '12691607', '11665193', '10289010']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7758202698827477
- 35 USC 102 Novelty (BERT): 0.5471414882560384
- Combined Prediction Score: 0.7529523917200768
- Mean Citation Score: 319.299128
- Max Citation Score: 415.3518
- Similarity Product: 313.4597420645714

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test