PATENT CLAIM ANALYSIS

Application Number: 15754311
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "263220"]

Abstract:
The invention relates generally to compounds of formula (I) that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Claim (Index 5):
A compound selected from\n N-(3-fluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)-9H-Purin-6-amine; 2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyridin-4-yl)-9H-Purin-6-amine; N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyridin-2-yl)-9H-Purin-6-amine; N-(3-fluoropyridin-4-yl)-2-(pyridin-2-yl)-9H-Purin-6-amine; 2-(5-fluoro-6-methylpyridin-2-yl)-N-(3-fluoropyridin-4-yl)-9H-Purin-6-amine; N-(4-((2-(6-methylpyridin-2-yl)-9H-Purin-6-yl)amino)pyridin-2-yl)acetamide; N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-9H-Purin-6-yl)amino)pyridin-2-yl)acetamide; N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-9H-Purin-6-yl)amino)pyridin-2-yl)acetamide; N-(4-((2-(pyridin-2-yl)-9H-Purin-6-yl)amino)pyridin-2-yl)acetamide; N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-9H-Purin-6-yl)amino)-5-fluoropyridin-2-yl)acetamide; N-(5-fluoro-4-((2-(6-(trifluoromethyl)pyridin-2-yl)-9H-Purin-6-yl)amino)pyridin-2-yl)acetamide; N-(3-fluoro-4-((2-(6-(trifluoromethyl)pyridin-2-yl)-9H-Purin-6-yl)amino)pyridin-2-yl)acetamide; N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-9H-Purin-6-yl)amino)-3-fluoropyridin-2-yl)acetamide; N-(4-((8-methyl-2-(6-(trifluoromethyl)pyridin-2-yl)-9H-Purin-6-yl)amino)pyridin-2-yl)acetamide; N-(5-fluoro-4-((8-methyl-2-(6-(trifluoromethyl)pyridin-2-yl)-9H-Purin-6-yl)amino)pyridin-2-yl)acetamide; N-(3-fluoropyridin-4-yl)-8-methyl-2-(6-(trifluoromethyl)pyridin-2-yl)-9H-Purin-6-amine; N-(4-((8-cyclopropyl-2-(6-(trifluoromethyl)pyridin-2-yl)-9H-Purin-6-yl)amino)pyridin-2-yl)acetamide; 8-cyclopropyl-N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyridin-2-yl)-9H-Purin-6-amine; Methyl (4-((2-(6-(trifluoromethyl)pyridin-2-yl)-9H-purin-6-yl)amino)pyridin-2-yl)carbamate; N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-9H-purin-6-yl)amino)pyridin-2-yl)cyclopropanecarboxamide; 2-methoxy-N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-9H-purin-6-yl)amino)pyridin-2-yl)acetamide; 3-methoxy-N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-9H-purin-6-yl)amino)pyridin-2-yl)propanamide; 4,4,4-trifluoro-N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-9H-purin-6-yl)amino)pyridin-2-yl)butanamide; N-(4-((2-(5-fluoro-6-methylpyridin-2-yl)-9H-purin-6-yl)amino)pyridin-2-yl)acetamide; and/or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 88.0
- Lexical Diversity: 1.41176
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15747843', '14977709', '15746597', '15755636', '12663504']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7998155596426998
- 35 USC 102 Novelty (BERT): 0.5315816861507485
- Combined Prediction Score: 0.7729921722935047
- Mean Citation Score: 308.121634
- Max Citation Score: 358.2882
- Similarity Product: 288.56931477352384

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test