PATENT CLAIM ANALYSIS

Application Number: 15978489
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["548", "188000"]

Abstract:
According to the present invention, it becomes possible to perform a process for converting into an α-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance. In the production of an α-substituted-D-cysteine or a salt thereof, it becomes possible to perform a process for converting the compound represented by general formula (2) into a compound represented by general formula (3S) in one step by allowing an enzyme or the like to act on the compound represented by general formula (2).

Claim (Index 1):
A method for producing an \u03b1-substituted cysteine represented by General Formula (1): wherein R 2  represents a C 1 -C 4  alkyl group or a salt thereof, said method comprising the steps of: (a) converting, by Curtius rearrangement reaction, a compound represented by General Formula (5): wherein R 1  represents a C 1 -C 10  alkyl group which is optionally substituted, a C 7 -C 20  aralkyl group which is optionally substituted, or a C 6 -C 12  aryl group which is optionally substituted, and R 2  has the same meaning as R 2  in the General Formula (1), to obtain a compound represented by General Formula (6): wherein R 1  and R 2  have the same meanings as R 1  and R 2  in the General Formula (5), and (b) subjecting said compound represented by General Formula (6) to a process of converting the isocyanate group to an amino group, a process of hydrolyzing the ester group, and a process of removing the tert-butyl group by action of an acid.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 93.0
- Lexical Diversity: 2.96104
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14888576', '11006027', '10416185', '12232229', '12000284']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.697287690135323
- 35 USC 102 Novelty (BERT): 0.5315677450490276
- Combined Prediction Score: 0.6807156956266934
- Mean Citation Score: 271.330502
- Max Citation Score: 350.26776
- Similarity Product: 288.4543237286568

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test