PATENT CLAIM ANALYSIS

Application Number: 16381988
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-10
Patent Classification: ["436", "063000"]

Abstract:
Fluorescence methods and systems that use an optical agent for measuring the pH of a fluid. The optical agent is a photonic nanostructure having a supramolecular structure, such as a shell cross-linked micelle that incorporates at least one linking group that includes one or more photoactive moieties.

Claim (Index 101):
A system for measuring the pH of a fluid in vivo, comprising:\n (a) an optical agent in liquid communication with a fluid in vivo, wherein the optical agent comprises:\n cross-linked block copolymers, wherein each of the block copolymers comprises one or more hydrophilic blocks and one or more hydrophobic blocks; and \n linking groups covalently cross linking at least a portion of the hydrophilic blocks of the block copolymers, wherein at least a portion of the linking groups comprise one or more pH-insensitive photoactive moieties; \n wherein the optical agent forms a supramolecular structure in aqueous solution, the supramolecular structure having one or more interior hydrophobic cores and one or more covalently cross-linked hydrophilic shells, wherein the one or more interior hydrophobic cores comprise the hydrophobic blocks of the block copolymers, and the one or more covalently cross-linked hydrophilic shells comprise the hydrophilic blocks of the block copolymers; and \n (b) a device for measuring the pH of the fluid, wherein the device comprises:\n an optical source for providing electromagnetic radiation; \n an electromagnetic radiation delivery system in optical communication with the optical source for providing at least a portion of the electromagnetic radiation to the optical agent administered to the fluid, thereby exciting fluorescence from the optical agent in the fluid; \n an electromagnetic radiation collection system in optical communication with the fluid for collecting at least a portion of the fluorescence from the optical agent and providing at least a portion of the fluorescence to a detector; \n a detector for receiving at least a portion of the fluorescence from the electromagnetic radiation collection system; \n wherein the detector measures a first fluorescence intensity at a first wavelength and a second fluorescence intensity at a second wavelength; \n wherein the second wavelength differs from the first wavelength; and \n a processor in optical or electronic communication with the detector; \n wherein the processor is programmed to:\n calculate a fluorescence intensity ratio of the first fluorescence intensity at the first wavelength to the second fluorescence intensity at the second wavelength; and \n compare the calculated fluorescence intensity ratio to a reference fluorescence intensity ratio to provide the pH of the fluid, wherein the reference fluorescence intensity ratio is generated by measuring fluorescence intensities for one or more reference fluid samples having known pH.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 100.0
- Lexical Diversity: 1.21951
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13697149', '15054739', '11972061', '14421882', '10777552']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6213849092892181
- 35 USC 102 Novelty (BERT): 0.5582813128769475
- Combined Prediction Score: 0.615074549647991
- Mean Citation Score: 316.25798
- Max Citation Score: 456.00604
- Similarity Product: 367.4984103488302

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test