PATENT CLAIM ANALYSIS

Application Number: 16061732
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "081000"]

Abstract:
Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

Claim (Index 1):
A compound of structural Formula I: or a pharmaceutically acceptable salt thereof wherein: R 1  and R 2  are independently selected from:\n (a) \u2014C 1-10 alkyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 8 , \u2014SH, \u2014NR 9 R 10 , \u2014C 3-6 cycloalkyl or spiro-C 3-6 cycloalkyl, \n (b) \u2014CH 2 -phenyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 11 , \u2014SH, \u2014NR 9 R 10  or \u2014C 1-3 alkyl, \n (c) \u2014C 3-8 cycloalkyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 11 , \u2014SH, \u2014NR 9 R 10  or \u2014C 1-3 alkyl, \n (d) aryl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 11 , \u2014SH, \u2014NR 9 R 10  or \u2014C 1-3 alkyl, \n (e) \u2014C 1-5 -alkyl-X\u2014C 1-5 alkyl wherein X is O, S or NH, \n (f) heteroaryl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 11 , \u2014SH, \u2014NR 9 R 10  or \u2014C 1-3 alkyl, or \n (g) a heterocyclic ring unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 11 , \u2014SF, \u2014NR 9 R 10 , \u2014C 1-3 alkyl, or \u2014CH 2 -phenyl; \n or R 1  and R 2  are joined together with the carbon to which they are both attached to form:\n (a) \u2014C 3-8 cycloalkyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 11 , \u2014SH, \u2014NR 9 R 10  or \u2014C 1-3 alkyl, \n (b) a 4 to 6-membered heterocyclic ring unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 11 , \u2014SH, \u2014NR 9 R 10 , \u2014C 1-3 alkyl or \u2014CH 2 -phenyl; or \n or unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 11 , \u2014SH, \u2014NR 9 R 10 , \u2014C 1-3 alkyl or \u2014CH 2 -phenyl; R 3  is an L-amino acid ester residue of formula (i), a D-amino acid ester residue of formula (ii), a glycine ester residue of formula (iii), a geminally di-substituted amino acid ester residue of formula (iv), or an L-proline ester residue of formula (v): R 4  is (a) \u2014C 1-4 alkyl, (b) \u2014C 1-4 alkyl substituted with \u2014OH, \u2014SH, \u2014SCH 3 , \u2014NH 2 , or \u2014NH\u2014C(\u2550NH)\u2014NH 2 , (c) \u2014CH 2 -phenyl, (d) \u2014CH 2 -phenol, (e) \u2014(CH 2 ) 1-2 \u2014COOH, (f) \u2014(CH 2 ) 1-2 \u2014CONH 2 , (g) \u2014CH 2 -1H-indole, (h) \u2014CH 2 -imidazole, (i) aryl; R 5  and R 6  are each independently selected from (a) \u2014C 1-4 alkyl, (b) \u2014C 1-4 alkyl substituted with \u2014OH, \u2014SH, \u2014SCH 3 , \u2014NH 2 , or \u2014NH\u2014C(\u2550NH)\u2014NH 2 , (c) \u2014CH 2 -phenyl, (d) \u2014CH 2 -phenol, (e) \u2014(CH 2 ) 1-2 \u2014COOH, (f) \u2014(CH 2 ) 1-2 \u2014CONH 2 , (g) \u2014CH 2 -1H-indole, (h) \u2014CH 2 -imidazole, (i) aryl or (j) heteroaryl; or R 5  and R 6  are joined together with the carbon to which they are both attached to form \u2014C 3-6 cycloalkyl or a 4 to 6-membered heterocyclic ring; R 7  is\n (a) \u2014C 1-10 alkyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 12 , \u2014SH, \u2014NR 13 R 14 , \u2014C 3-6 cycloalkyl or spiro-C 3-6 cycloalkyl, \n (b) \u2014CH 2 -phenyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 15 , \u2014SH, \u2014NR 13 R 14  or \u2014C 1-3 alkyl, \n (c) \u2014C 3-8 cycloalkyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 15 , \u2014SH, \u2014NR 13 R 14  or \u2014C 1-3 alkyl, \n (d) aryl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 15 , \u2014SH, \u2014NR 13 R 14  or \u2014C 1-3 alkyl, \n (e) \u2014C 1-5 alkyl-X-C 1-5 alkyl wherein X is O, S or NH; \n (f) heteroaryl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 15 , \u2014SH, \u2014NR 13 R 14  or \u2014C 1-3 alkyl, or \n (g) a heterocyclic ring unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 15 , \u2014SH, \u2014NR 13 R 14  or \u2014C 1-3 alkyl; \n R 8  is independently selected at each occurrence from \u2014H or \u2014C 3-6 cycloalkyl; R 9  is independently selected at each occurrence from \u2014H, \u2014C 1-3 alkyl or \u2014C 3-6 cycloalkyl; R 10  is independently selected at each occurrence from \u2014H, \u2014C 1-3 alkyl or \u2014C 3-6 cycloalkyl; R 11  is independently selected at each occurrence from \u2014H, \u2014C 1-3 alkyl or \u2014C 3-6 cycloalkyl; R 12  is \u2014H or \u2014C 3-6 cycloalkyl; R 13  and R 14  are each independently selected from \u2014H, \u2014C 1-3 alkyl or \u2014C 3-6 cycloalkyl; and R 15  is selected from \u2014H, \u2014C 1-3 alkyl or \u2014C 3-6 cycloalkyl.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 94.0
- Lexical Diversity: 1.58824
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16327631', '15231365', '15847971', '15012445', '15616756']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7827729305403752
- 35 USC 102 Novelty (BERT): 0.5985119287478233
- Combined Prediction Score: 0.76434683036112
- Mean Citation Score: 391.294098
- Max Citation Score: 522.6205
- Similarity Product: 438.9077233153582

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test