PATENT CLAIM ANALYSIS

Application Number: 15956133
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-04
Patent Classification: ["514", "017700"]

Abstract:
Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

Claim (Index 55):
The method of  claim 1 , wherein the necrosis inhibitor is a compound of Formula V-A: or a pharmaceutically acceptable salt, an ester, or a prodrug thereof, wherein: R 1  is C 1 -C 6 alkyl, halogen, hydroxyl, C 1 -C 6 alkoxyl, or \u2014N(R 4 ) 2 ; R 2  is R 3  is \u2014C 1 -C 6 alkylene-CN; R 4  represents independently for each occurrence hydrogen, C 1 -C 6 alkyl, aryl, or aralkyl; R 5  represents independently for each occurrence C 1 -C 6 alkyl, halogen, hydroxyl, C 1 -C 6 alkoxyl, \u2014N(R 4 ) 2 , \u2014C(O)R 4 , CO 2 R 4 , or C(O)N(R 4 ) 2 ; B is a 5-6 membered heterocyclic or carbocylic ring; and n and p each represent independently 0, 1, or 2.

Metadata:
- Claim Count in Document: 73.0
- Percentile: 91.0
- Lexical Diversity: 1.66102
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15093480', '15288214', '14934810', '12086792', '15100967']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7793343099823054
- 35 USC 102 Novelty (BERT): 0.7418175662223334
- Combined Prediction Score: 0.7755826356063082
- Mean Citation Score: 535.4984059999998
- Max Citation Score: 823.15753
- Similarity Product: 811.1696217785192

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test