PATENT CLAIM ANALYSIS

Application Number: 15880309
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["435", "006110"]

Abstract:
The present invention discloses a method of detecting the presence of mutated genes, mRNAs or microRNAs in a subject. The method comprises the following steps: (1) Provide a body fluid sample containing cells, circulating tumor cells (CTCs), and/or extracellular vesicles (EVs); and use an analyzer having overhang molecular beacons to measure fluorescence signals generated by interactions between the body fluid sample and the overhang molecular beacons, so as to detect the presence of the mutated genes, mRNAs or microRNA. Furthermore, a biochip comprising a gold coating substrate and tethered lipoplex nanoparticles encapsulating the overhang molecular beacons is also provided in the invention.

Claim (Index 13):
A biochip for detecting mutated genes, mRNAs or microRNAs, comprising a gold coating substrate and lipoplex nanoparticles, wherein the lipoplex nanoparticles tether on the gold coating substrate and encapsulate a plaurity of overhang molecular beacons which comprise a stem having at least 9-base pairs, a loop having at least 4 bases, an overhang section of at least 5 complementary bases to the mutated genes, mRNAs or microRNAs at the end of the stem, a fluorescence dye and a quencher at the 3\u2032 end; and wherein the last complementary base of the overhang section or the first complementary base of the stem in the overhang molecular beacons is corresponding to a single-point mutated base of the mutated gene, mRNAs, or microRNAs.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 86.0
- Lexical Diversity: 1.63014
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13890957', '13264843', '12676135', '14353959', '11514316']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5912327015194355
- 35 USC 102 Novelty (BERT): 0.4872144595016305
- Combined Prediction Score: 0.580830877317655
- Mean Citation Score: 214.285464
- Max Citation Score: 229.27625
- Similarity Product: 172.43636964976787

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test