PATENT CLAIM ANALYSIS

Application Number: 16068262
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "275000"]

Abstract:
The disclosure provides compounds of the formula I and the pharmaceutically acceptable salts thereof. The variables, e.g. R 1 , R 2 , R 3 , R 4 , A, B, J, V, W, M, J and Ar are defined herein. The disclosure also provides pharmaceutical compositions comprising a compound or salt of formula I and a pharmaceutically acceptable carrier, methods of inhibiting dihydrofolate reductase (DHFR) in vitro or in vivo with a compound or salt of formula I, and methods of treating a bacterial infections, fungal infections, and protozoal infections with a compound or salt of formula I. A compound or salt of formula I can be the first and only active ingredient used in a pharmaceutical composition or method of this disclosure or may be combined with one or more additional active ingredients that are not compounds or salts of formula I.

Claim (Index 12):
The compound or salt of  claim 1 , wherein the compound is a compound of the formula I-A wherein the compound is selected from the compounds listed in TABLE I: TABLE 1 Cpd A V W M Ar 13 H OCH 3 H H o-COOH phenyl 14 H OCH 3 H H m-COOH phenyl 15 H OCH 3 H H p-COOH phenyl 16 H H OCH 3 H p-COOH phenyl 29 S\u2014CH 3 OCH 3 H H p-COOH phenyl 30 R\u2014CH 3 OCH 3 H H p-COOH phenyl 31 R\u2014CH 3 H OCH 3 H p-COOH phenyl 32 S\u2014CH 3 H OCH 3 H p-COOH phenyl 33 S\u2014CH 3 OCH 3 H H p-COOCH 3  phenyl 34 R\u2014CH 3 OCH 3 H H p-COOCH 3  phenyl 35 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 p-O\u2014C(O)-OHphenyl 36 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 p-OHphenyl 37 H H \u2014O\u2014CH 2 \u2014O\u2014 p-OHphenyl 38 H H \u2014O\u2014CH 2 \u2014O\u2014 3-F,4-OH-phenyl 39 H H \u2014O\u2014CH 2 \u2014O\u2014 3,5-di-F,4-OH-phenyl 40 H H \u2014O\u2014CH 2 \u2014O\u2014 3,5-di-F,4-OCH 3 -phenyl 41 S\u2014CH3 H \u2014O\u2014CH 2 \u2014O\u2014 p-COOH-phenyl 42 R\u2014CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 p-COOH-phenyl 43 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 2,3,5-tri-F,4-OH-phenyl 44 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 2,3,5,6-tetra-F,4-OH-phenyl 45 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 3-CN, 4-OH-phenyl 46 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 4-CH 3 SO 2 HN-phenyl 47 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 4-CH 3 HNSO 2 -phenyl   48 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014   49 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014   50 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 3,4,-di-OH-phenyl   51 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014   52 H H OMe H   53 H H OMe H   54 CH 3 H \u2014O\u2014CH 2 \u2014O\u2014   55 R\u2014CH 3 H \u2014O\u2014CH 2 \u2014O\u2014 pyrid-4-yl   56 H OCH 3 H H   57 R\u2014CH 3 OCH 3 H H pyrid-4-yl 58 R\u2014CH 3 H OCH 3 H p-COOH phenyl 59 H H OCH 3 H p-COOH phenyl 60 H H OCH 3 OCH 3 4-Pyridyl.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 95.0
- Lexical Diversity: 2.16
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11345201', '14620997', '12754057', '14336427', '12622753']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7533380290355326
- 35 USC 102 Novelty (BERT): 0.5202583589658266
- Combined Prediction Score: 0.730030062028562
- Mean Citation Score: 249.46942
- Max Citation Score: 259.62924
- Similarity Product: 161.5247888812923

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test