PATENT CLAIM ANALYSIS

Application Number: 16301027
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["514", "254030"]

Abstract:
Provided are a preparation method for a crystalline form of the compound represented by formula (A), as well as a method for preparation thereof, a composition thereof, and an application thereof in preparing an angiotensin II receptor antagonist or an application in preparing a drug for preventing and/or treating hypertension, chronic heart failure and diabetic nephropathy.

Claim (Index 12):
The preparation method of the crystalline form according to  claim 2 , wherein a preparation method of the crystalline form II comprises one or more of the following proceedings:\n (1) dissolving the compound of formula (A) in a solvent to obtain a clear solution, evaporating the solution to dryness at room temperature to give the crystalline form II; preferably, the solvent is selected from a mixture of ethanol and ethyl acetate, a mixture of acetone and ethyl acetate, a mixture of acetone and isopropyl ether, or a mixture of acetone and n-heptane; more preferably, the volume ratio of the two solvents in the mixture is from 1:8 to 8:1, and most preferably from 1:5 to 5:1; (2) adding the compound of formula (A) to a solvent to obtain a clear solution, a saturated solution, a supersaturated solution or a suspension, and stirring to obtain the crystalline form II; preferably, the solvent is selected from isopropanol, sec-butanol, ethyl acetate, toluene, isopropyl acetate, a mixture of ethanol and ethyl acetate, a mixture of ethanol and isopropyl acetate, a mixture of ethanol and toluene, a mixture of acetone and n-heptane, or a mixture of 1,4-dioxane and n-heptane; more preferably, the volume ratio of the two solvents in the mixture is from 1:8 to 8:1, and most preferably from 1:5 to 5:1; preferably, stirring at room temperature for 10 minutes to 5 days, most preferably stirring at room temperature for 3 hours to 3 days; (3) dissolving the compound of formula (A) in a good solvent to obtain a clear solution, and adding an anti-solvent under stirring to obtain the crystalline form II; preferably, the good solvent is selected from methyl ethyl ketone, dimethyl sulfoxide or 1,4-dioxane, and the anti-solvent is selected from n-heptane, isopropyl ether or isopropyl acetate; (4) dissolving the compound of formula (A) in a solvent under heating to obtain a clear solution, and cooling the solution to obtain the crystalline form II; preferably, the solvent is selected from sec-butanol, nitromethane, acetone, or tetrahydrofuran; preferably, the heating temperature is from 40\u00b0 C. to 90\u00b0 C., and most preferably, the heating temperature is from 50\u00b0 C. to 70\u00b0 C.; (5) placing a saturated ethanol solution of the compound of the formula (A) in a solvent atmosphere of isopropyl ether or isopropyl acetate until the crystalline form II is precipitated out; and (6) placing the compound of formula (A) in a solvent atmosphere of toluene, isopropanol, tetrahydrofuran or ethyl acetate for 1-3 days to obtain the crystalline form II.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 98.0
- Lexical Diversity: 1.46512
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13001715', '15740719', '13805920', '14116099', '13505360']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7798098558262678
- 35 USC 102 Novelty (BERT): 0.5355024861078788
- Combined Prediction Score: 0.7553791188544289
- Mean Citation Score: 333.132024
- Max Citation Score: 349.10037
- Similarity Product: 268.51450963156344

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test