PATENT CLAIM ANALYSIS

Application Number: 15990524
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-02
Patent Classification: ["514", "019300"]

Abstract:
T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of mutational libraries of TCRs in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast (i.e. directed evolution). In embodiments, the engineered TCRs can be used in soluble form for targeted delivery in vivo, or as genes introduced into T cells in an adoptive T cell setting.

Claim (Index 10):
The modified T cell receptor of  claim 3 , wherein the modified T cell receptor comprises one or more of the following amino acid mutations: TCR V\u03b1 chain mutations N92H, N100G, A101W, R102Y, and L103T.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 93.0
- Lexical Diversity: 1.41935
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15037485', '13500123', '14813782', '15327984', '13946313']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8234593880063744
- 35 USC 102 Novelty (BERT): 0.6027378546468208
- Combined Prediction Score: 0.8013872346704191
- Mean Citation Score: 453.161688
- Max Citation Score: 624.79297
- Similarity Product: 439.9417638197362

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test