PATENT CLAIM ANALYSIS

Application Number: 15779038
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["536", "103000"]

Abstract:
The present application provides an improved process for the preparation of sugammadex which comprises the halogenation of γ-cyclodextrin in a suitable organic solvent to give 6-per-deoxy-6-per-halo-γ-cyclodextrin, wherein halo is bromo or chloro, reacting the halogenated γ-cyclodextrin with 3-mercaptopropionic acid in the presence of alkoxide base to obtain sugammadex of formula I. This application also provides isolation of 6-per-deoxy-6-per-chloro-γ-cyclodextrin as a crystalline compound and its use for the preparation of sugammadex of formula (I).

Claim (Index 9):
The process according to  claim 1 , wherein isolation of 6-per-deoxy-6-per-halo-\u03b3-cyclodextrin of formula III, comprises:\n b1) adding an alcohol, selected from methanol, ethanol, propanol, isopropyl alcohol, n-butanol, iso-butanol, and tert-butanol, b2) mixing the solution of step b1) with a mixture of water, base and alcohol, wherein the alcohol is the same as used in step b1), b3) stirring, and c) isolating 6-per-deoxy-6-per-halo-\u03b3-cyclodextrin.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 93.0
- Lexical Diversity: 1.43636
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16087065', '15779040', '15580408', '13818658', '15873505']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6381265312898853
- 35 USC 102 Novelty (BERT): 0.5722248631096903
- Combined Prediction Score: 0.6315363644718658
- Mean Citation Score: 354.402894
- Max Citation Score: 460.62976
- Similarity Product: 396.34054399749766

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test