PATENT CLAIM ANALYSIS

Application Number: 15753006
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "001890"]

Abstract:
The present invention discloses a radioisotope  18 F substituted thiamine, synthesis method, and use thereof in small animal PET/CT imaging. The radioisotope  18 F substituted thiamine has a structure of The synthesis method comprises radiochemical synthesis by using existing precursors. In the present invention, the hydroxyl in the hydroxyethyl on the thiazole cycle of thiamine is replaced by radioisotope  18 F, to prepare a PET tracer. The radioisotope  18 F substituted thiamine of the present invention successfully enters the brains of various strains of mice, and the uptake in the brains of thiamine-deficient mice is obviously greater than that in normal control. The present invention is useful in the preparation of a brain imaging tracer for clinical trials of Alzheimer's disease and tumors.

Claim (Index 8):
The method for synthesizing radioisotope  18 F substituted thiamine hydrobromide according to  claim 4 , wherein the mass ratio of 2-(4-methylthiazol-5-yl)ethyl 4-methylbenzenesulfonate in Step 1) to 2-methyl-5-bromomethyl-6-aminopyrimidine hydrobromide in Step 2) is 1:1.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.97059
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15807306', '15674701', '14031812', '12836926', '14101960']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7355020280676646
- 35 USC 102 Novelty (BERT): 0.4874182194145681
- Combined Prediction Score: 0.710693647202355
- Mean Citation Score: 202.841408
- Max Citation Score: 217.18102
- Similarity Product: 165.65325013601782

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test