PATENT CLAIM ANALYSIS

Application Number: 16060559
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "184000"]

Abstract:
The present invention relates to novel monomaleimide-functionalized platinum compounds of formula (I), including in particular novel monomaleimide-functionalized oxaliplatin and carboplatin derivatives, as well as their use as medicaments, particularly for the treatment or prevention of cancer.

Claim (Index 1):
A compound of the following formula (I) wherein:\n R 1  and R 2  are joined together to form a moiety (A1), (A2) or (A3): \n R 3  and R 4  are joined together to form a moiety (B1), or R 3  is a moiety (B2) and R 4  is \u2014NH 3 , or R 3  and R 4  are each \u2014NH 3 : R 5  is \u2014N(R 51 )\u2014 or \u2014CH 2 \u2014; R 51  is hydrogen or C 1-8  alkyl; R 6  is C 1-8  alkylene, wherein one or two \u2014CH 2 \u2014 units comprised in said C 1-8  alkylene are each optionally replaced by a group independently selected from \u2014O\u2014, \u2014CO\u2014, \u2014C(\u2550O)O\u2014, \u2014N(R 61 )\u2014, \u2014N(R 61 )\u2014CO\u2014, \u2014CO\u2014N(R 61 )\u2014, arylene, and heteroarylene, wherein said arylene and said heteroarylene are each optionally substituted with one or more groups R 62 ; each R 61  is independently selected from hydrogen and C 1-8  alkyl; each R 62  is independently selected from C 1-8  alkyl, C 2-8  alkenyl, C 2-8  alkynyl, \u2014(C 0-3  alkylene)-OH, \u2014(C 0-3  alkylene)-O(C 1-8  alkyl), \u2014(C 0-3  alkylene)-SH, \u2014(C 0-3  alkylene)-S(C 1-8  alkyl), \u2014(C 0-3  alkylene)-NH 2 , \u2014(C 0-3  alkylene)-NH(C 1-8  alkyl), \u2014(C 0-3  alkylene)-N(C 1-8  alkyl)(C 1-8  alkyl), \u2014(C 0-3  alkylene)-halogen, \u2014(C 0-3  alkylene)-(C 1-8  haloalkyl), \u2014(C 0-3  alkylene)-CF 3 , \u2014(C 0-3  alkylene)-CN, \u2014(C 0-3  alkylene)-CHO, \u2014(C 0-3  alkylene)-CO\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-COOH, \u2014(C 0-3  alkylene)-CO\u2014O\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-O\u2014CO\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-CO\u2014NH 2 , \u2014(C 0-3  alkylene)-CO\u2014NH(C 1-8  alkyl), \u2014(C 0-3  alkylene)-CO\u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014(C 0-3  alkylene)-NH\u2014CO\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-N(C 1-8  alkyl)-CO\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-SO 2 \u2014NH 2 , \u2014(C 0-3  alkylene)-SO 2 \u2014NH(C 1-8  alkyl), \u2014(C 0-3  alkylene)-SO 2 \u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014(C 0-3  alkylene)-NH\u2014SO 2 \u2014(C 1-8  alkyl), and \u2014(C 0-3  alkylene)-N(C 1-8  alkyl)-SO 2 \u2014(C 1-8  alkyl); R 7  is selected from hydrogen, C 1-8  alkyl, C 2-8  alkenyl, C 2-8  alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, \u2014O\u2014(C 1-8  alkyl), \u2014O\u2014(C 2-8  alkenyl), \u2014O\u2014(C 2-8  alkynyl), \u2014O-cycloalkyl, \u2014O-heterocycloalkyl, \u2014O-aryl, \u2014O-heteroaryl, \u2014N(R 71 )\u2014(C 1-8  alkyl), \u2014N(R 71 )\u2014(C 2-8  alkenyl), \u2014N(R 71 )\u2014(C 2-8  alkynyl), \u2014N(R 71 )-cycloalkyl, \u2014N(R 71 )-heterocycloalkyl, \u2014N(R 71 )-aryl, and \u2014N(R 71 )-heteroaryl, wherein said C 1-8  alkyl or the C 1-8  alkyl moiety comprised in any of the aforementioned groups, said C 2-8  alkenyl or the C 2-8  alkenyl moiety comprised in any of the aforementioned groups, and said C 2-8  alkynyl or the C 2-8  alkynyl moiety comprised in any of the aforementioned groups are each optionally substituted with one or more groups R 72 , and further wherein said cycloalkyl or the cycloalkyl moiety comprised in any of the aforementioned groups, said heterocycloalkyl or the heterocycloalkyl moiety comprised in any of the aforementioned groups, said aryl or the aryl moiety comprised in any of the aforementioned groups, and said heteroaryl or the heteroaryl moiety comprised in any of the aforementioned groups are each optionally substituted with one or more groups R 73 ; each R 71  is independently selected from hydrogen and C 1-8  alkyl; each R 72  is independently selected from \u2014OH, \u2014O(C 1-8  alkyl), \u2014SH, \u2014S(C 1-8  alkyl), \u2014NH 2 , \u2014NH(C 1-8  alkyl), \u2014N(C 1-8  alkyl)(C 1-8  alkyl), halogen, C 1-8  haloalkyl, \u2014CF 3 , \u2014CN, \u2014CHO, \u2014CO\u2014(C 1-8  alkyl), \u2014COOH, \u2014CO\u2014O\u2014(C 1-8  alkyl), \u2014O\u2014CO\u2014(C 1-8  alkyl), \u2014CO\u2014NH 2 , \u2014CO\u2014NH(C 1-8  alkyl), \u2014CO\u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014NH\u2014CO\u2014(C 1-8  alkyl), \u2014N(C 1-8  alkyl)-CO\u2014(C 1-8  alkyl), \u2014SO 2 \u2014NH 2 , \u2014SO 2 \u2014NH(C 1-8  alkyl), \u2014SO 2 \u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014NH\u2014SO 2 \u2014(C 1-8  alkyl), and \u2014N(C 1-8  alkyl)-SO 2 \u2014(C 1-8  alkyl); each R 73  is independently selected from C 1-8  alkyl, C 2-8  alkenyl, C 2-8  alkynyl, \u2014(C 0-3  alkylene)-OH, \u2014(C 0-3  alkylene)-O(C 1-8  alkyl), \u2014(C 0-3  alkylene)-SH, \u2014(C 0-3  alkylene)-S(C 1-8  alkyl), \u2014(C 0-3  alkylene)-NH 2 , \u2014(C 0-3  alkylene)-NH(C 1-8  alkyl), \u2014(C 0-3  alkylene)-N(C 1-8  alkyl)(C 1-8  alkyl), \u2014(C 0-3  alkylene)-halogen, \u2014(C 0-3  alkylene)-(C 1-8  haloalkyl), \u2014(C 0-3  alkylene)-CF 3 , \u2014(C 0-3  alkylene)-CN, \u2014(C 0-3  alkylene)-CHO, \u2014(C 0-3  alkylene)-CO\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-COOH, \u2014(C 0-3  alkylene)-CO\u2014O\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-O\u2014CO\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-CO\u2014NH 2 , \u2014(C 0-3  alkylene)-CO\u2014NH(C 1-8  alkyl), \u2014(C 0-3  alkylene)-CO\u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014(C 0-3  alkylene)-NH\u2014CO\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-N(C 1-8  alkyl)-CO\u2014(C 1-8  alkyl), \u2014(C 0-3  alkylene)-SO 2 \u2014NH 2 , \u2014(C 0-3  alkylene)-SO 2 \u2014NH(C 1-8  alkyl), \u2014(C 0-3  alkylene)-SO 2 \u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014(C 0-3  alkylene)-NH\u2014SO 2 \u2014(C 1-8  alkyl), and \u2014(C 0-3  alkylene)-N(C 1-8  alkyl)-SO 2 \u2014(C 1-8  alkyl); each R 8  is independently selected from C 1-8  alkyl, C 2-8  alkenyl, C 2-8  alkynyl, \u2014OH, \u2014O\u2014(C 1-8  alkyl), \u2014SH, \u2014S\u2014(C 1-8  alkyl), \u2014NH 2 , \u2014NH(C 1-8  alkyl), \u2014N(C 1-8  alkyl)(C 1-8  alkyl), halogen, C 1-8  haloalkyl, \u2014CF 3 , \u2014CN, \u2014CHO, \u2014CO\u2014(C 1-8  alkyl), \u2014COOH, \u2014CO\u2014O\u2014(C 1-8  alkyl), \u2014O\u2014CO\u2014(C 1-8  alkyl), \u2014CO\u2014NH 2 , \u2014CO\u2014NH(C 1-8  alkyl), \u2014CO\u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014NH\u2014CO\u2014(C 1-8  alkyl), \u2014N(C 1-8  alkyl)-CO\u2014(C 1-8  alkyl), \u2014SO 2 \u2014NH 2 , \u2014SO 2 \u2014NH(C 1-8  alkyl), \u2014SO 2 \u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014NH\u2014SO 2 \u2014(C 1-8  alkyl), and \u2014N(C 1-8  alkyl)-SO 2 \u2014(C 1-8  alkyl); each R 9  is independently selected from C 1-8  alkyl, C 2-8  alkenyl, C 2-8  alkynyl, \u2014OH, \u2014O\u2014(C 1-8  alkyl), \u2014SH, \u2014S\u2014(C 1-8  alkyl), \u2014NH 2 , \u2014NH(C 1-8  alkyl), \u2014N(C 1-8  alkyl)(C 1-8  alkyl), halogen, C 1-8  haloalkyl, \u2014CF 3 , \u2014CN, \u2014CHO, \u2014CO\u2014(C 1-8  alkyl), \u2014COOH, \u2014CO\u2014O\u2014(C 1-8  alkyl), \u2014O\u2014CO\u2014(C 1-8  alkyl), \u2014CO\u2014NH 2 , \u2014CO\u2014NH(C 1-8  alkyl), \u2014CO\u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014NH\u2014CO\u2014(C 1-8  alkyl), \u2014N(C 1-8  alkyl)-CO\u2014(C 1-8  alkyl), \u2014SO 2 \u2014NH 2 , \u2014SO 2 \u2014NH(C 1-8  alkyl), \u2014SO 2 \u2014N(C 1-8  alkyl)(C 1-8  alkyl), \u2014NH\u2014SO 2 \u2014(C 1-8  alkyl), and \u2014N(C 1-8  alkyl)-SO 2 \u2014(C 1-8  alkyl); n is an integer of 0 to 8; and m is an integer of 0 to 6; or a pharmaceutically acceptable salt or solvate thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 94.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['10500516', '15093345', '14305643', '11691374', '15037941']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7640435883979227
- 35 USC 102 Novelty (BERT): 0.5151493767394941
- Combined Prediction Score: 0.7391541672320799
- Mean Citation Score: 284.677548
- Max Citation Score: 286.78967
- Similarity Product: 210.0884807781559

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test