PATENT CLAIM ANALYSIS

Application Number: 15761676
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["424", "450000"]

Abstract:
The present invention provides improved stable liposomal formulations and method of preparation thereof. The liposomal formulations include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG-lipid, and a taxane, wherein the taxane is docetaxel or a derivative thereof. The liposomal formulations have improved stability and extended shelf-life. The present invention also provides pharmaceutical compositions comprising a liposomal formulation for the treatment of cancer.

Claim (Index 22):
A method for preparing a stable liposomal formulation comprising the steps of:\n i) forming a first liposome having a lipid bilayer including a phosphatidylcholine lipid and a sterol, wherein the lipid bilayer encapsulates an interior environment containing an aqueous solution; ii) loading the first liposome with a therapeutic agent, or a pharmaceutically-acceptable salt thereof, to form a loaded liposome; iii) incorporating a PEG-lipid into the lipid bilayer of the loaded liposome; and iv) adjusting the pH of the liposomal formulation to about 7.1 to about 7.4.

Metadata:
- Claim Count in Document: 45.0
- Percentile: 90.0
- Lexical Diversity: 1.69048
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15407512', '15253307', '14255637', '15301570', '14208297']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7587732714083726
- 35 USC 102 Novelty (BERT): 0.5251996788738277
- Combined Prediction Score: 0.7354159121549181
- Mean Citation Score: 330.527132
- Max Citation Score: 337.90787
- Similarity Product: 213.64579930804783

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test