PATENT CLAIM ANALYSIS

Application Number: 16020395
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "001900"]

Abstract:
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer's Disease or frontotemporal dementia.

Claim (Index 22):
A method for mediating cholesterol efflux in a mammal, said method comprising administering to said mammal a polypeptide having cholesterol efflux activity, wherein the polypeptide comprises an amphipathic \u03b1-helix that has a non-polar surface and a polar surface, wherein the polar surface comprises charged and uncharged amino acid residues at the lipid-water interface and, wherein the \u03b1-helix amino acid sequence:\n has at least 60% identity to SEQ ID NO:1; has an acidic amino acid residue at positions 1, 7, 8, 15, 18, and 19 as determined with reference to SEQ ID NO:1; has an aliphatic amino acid independently selected from V, L, or I, or an uncharged amino acid analog thereof, at positions 10, 13, 16, and 20, as determined with reference to SEQ ID NO:1; wherein the uncharged amino acid analog has an aliphatic side chain and has a hydrophobicity of V or greater than V; and has an uncharged polar amino acid residue at at least two of positions 3, 14, and 23 as determined with reference to SEQ ID NO:1.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 94.0
- Lexical Diversity: 1.63158
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14774682', '14216749', '12519116', '12999966', '11014187']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7956762662274979
- 35 USC 102 Novelty (BERT): 0.6682728653995947
- Combined Prediction Score: 0.7829359261447076
- Mean Citation Score: 534.392214
- Max Citation Score: 703.3606
- Similarity Product: 620.6498625584363

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test