PATENT CLAIM ANALYSIS

Application Number: 16010755
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["548", "245000"]

Abstract:
Heterocyclic compounds are described that are lysophosphatidic acid receptor ligands that are useful in the treatment of lysophosphatidic acid receptor-dependent diseases and conditions, including but not limited to diseases involving fibrosis, such as fibrosis of the heart, kidney, liver and lung, and scleroderma; inflammatory diseases such as diabetic nephropathy and nonalcoholic steatohepatitis (NASH); ocular diseases such as diseases involving retinal degeneration; nerve diseases such as pruritus and pain.

Claim (Index 17):
A compound having the structure of Formula X or a pharmaceutically acceptable salt or prodrug thereof,\n wherein R A  is \u2014CO 2 H, \u2014CO 2 R B , \u2014CN, tetrazolyl, \u2014C(\u2550O)NH 2 , \u2014C(\u2550O)NHR B , C(\u2550O)NHSO 2 R B  or \u2014C(\u2550O)NHCH 2 CH 2 SO 3 H or a carboxylic acid isostere; \n R B  is optionally substituted C 1 -C 4  alkyl or has the structure of one of \n L 1  is optionally substituted C 1 -C 6  alkylene; C 1 -C 6  fluoroalkylene; or optionally substituted C 1 -C 6  heteroalkylene, or L 1 , when present is \u2014CH 2 \u2014, or disubstituted dimethylmethane;\n A 1  is N or C; \n Ring A has the structure of one of: \n R C  is \u2014CN, \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014OC 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, or C 1 -C 4  fluoroalkyl; R D  is \u2014N(R F )\u2014C(\u2550O)XCH(R G )\u2014CY, wherein X is O and CY is phenyl substituted with one R H : R E , R F  and R G  independently are \u2014H or C 1 -C 4  alkyl or C 3 -C 6  cycloalkyl or R E  and R F  independently are \u2014H or C 1 -C 4  alkyl or C 1 -C 6  cycloalkyl and one R G  is \u2014C 1 -C 4  alkyl and is taken together with the R H  pheny moiety of the Ring A R D  substituent and the carbon atom to which R G  and said phenyl moiety is attached to define a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, and the other R G , if present, is as defined for R E ; each R H  is independently \u2014H, halogen, \u2014CN, \u2014NO 2 , \u2014OH, \u2014OR J , \u2014SR J , \u2014S(\u2550O)R J , \u2014S(\u2550O) 2 R J , \u2014N(R J )S(\u2550O) 2 R J , \u2014S(\u2550O) 2 N(R L ) 2 , \u2014C(\u2550O)R J , \u2014OC(\u2550O)R J , \u2014CO 2 R J , \u2014OCO 2 R J , \u2014N(R L ) 2 , \u2014C(\u2550O)N(R L ) 2 , \u2014OC(\u2550O)N(R L ) 2 , \u2014NR J C(\u2550O)N(R L ) 2 , \u2014NR J C(\u2550O)R J , \u2014NR J C(\u2550O)OR J , C 1 -C 4  alkyl, C 1 -C 4  fluoroalkyl, C 1 -C 4  fluoroalkoxy, C 1 -C 4  alkoxy, and C 1 -C 4  heteroalkyl; R J  is substituted or unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 1 -C 6  heteroalkyl, substituted or unsubstituted C 1 -C 6  fluoroalkyl, substituted or unsubstituted C 3 -C 6  cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014C 1 -C 4  alkylene-(substituted or unsubstituted C 3 -C 6  cycloalkyl), \u2014C 1 -C 4  alkylene-(substituted or unsubstituted heterocycloalkyl), \u2014C 1 -C 4  alkylene-(substituted or unsubstituted aryl), or C 1 -C 4  alkylene-(substituted or unsubstituted heteroaryl); R L  independently are \u2014H, substituted or unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 1 -C 6  heteroalkyl, substituted or unsubstituted C 1 -C 6  fluoroalkyl, substituted or unsubstituted C 3 -C 6  cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014C 1 -C 4  alkylene-(substituted or unsubstituted C 3 -C 6  cycloalkyl), \u2014C 1 -C 4  alkylene-(substituted or unsubstituted heterocycloalkyl), \u2014C 1 -C 4  alkylene(substituted or unsubstituted aryl), or \u2014C 1 -C 4  alkylene-(substituted or unsubstituted heteroaryl), or when R H  is \u2014S(\u2550O) 2 N(R L ) 2 , \u2014N(R L ) 2 , \u2014C(\u2550O)N(R L ) 2 , \u2014OC(\u2550O)N(R L ) 2  or \u2014N(R J )C(\u2550O)N(R L ) 2 , each R L  is independently \u2014H or C 1 -C 6  alkyl, or the R L  groups independently are C 1 -C 6  alkyl which are taken together with the N atom to which they are attached to define a substituted or unsubstituted heterocycle.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 1.61224
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16000283', '14776954', '13388502', '13133636', '14755383']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7847086771496344
- 35 USC 102 Novelty (BERT): 0.5715649274002417
- Combined Prediction Score: 0.7633943021746952
- Mean Citation Score: 381.080306
- Max Citation Score: 479.01657
- Similarity Product: 390.8608396690893

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test