PATENT CLAIM ANALYSIS

Application Number: 16029166
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "210180"]

Abstract:
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R 1 , R 2 , R 4  and R 7  are defined herein.

Claim (Index 20):
The compound of  claim 1 , having Formula (IV) or a pharmaceutically acceptable salt, enantiomer hydrate, solvate, prodrug, isomer, or tautomer thereof, wherein: Ar is C 6 -C 10  aryl or heteroaryl; each R 10  is independently at each occurrence selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  hydroxyalkyl, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, \u2014OR i , \u2014NR a R i , CN, oxo, \u2014(CR k R l ) n S(O) 2 R i , \u2014(CR k R l ) n NR a S(O) 2 R i , \u2014(CR k R l ) n S(O) 2 NR a R i , \u2014(CR k R l ) n NR a R i S(O) 2 NR a R i , \u2014(CR k R l ) n C(O)OR a , \u2014(CR k R l ) n C(O)R i , \u2014(CR k R l ) n C(O)NR a R i , \u2014(CR k R l ) n R i , \u2014(CR k R l ) n NR a C(O)NR b , and \u2014(CR k R l ) n NR a C(O)OR b , wherein each alkyl is substituted with one or more R 11 ; or two R 10  together when on adjacent carbons form an aryl ring optionally substituted with one or more R 11 ; or two R 10  together when on adjacent carbons form a heteroaryl ring optionally substituted with one or more R 11 ; or two R 10  together when on adjacent carbons form a heterocycloalkyl ring optionally substituted with one or more R 11 ; each R 11  is independently at each occurrence selected from halogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, hydroxy, CN, C 1 -C 6  hydroxyalkyl, \u2014(CR k R l ) m NH 2 , C 1 -C 6  alkylamino, C 1 -C 6  dialkylamino, \u2014C(O)NR a R b , \u2014C(O)OR a , \u2014C(O)R a , \u2014S(O) 2 R a , \u2014C(O)H, \u2014NR a C(O)OR a , \u2014NR a C(O)C 1 -C 6  alkyl, or oxo; or two R 11  together can form a heterocycloalkyl ring; R a  and R b  are each independently at each occurrence hydrogen, C 1 -C 6  alkyl, \u2014C 1 -C 4  alkyl(aryl), or aryl, wherein the alkyl and aryl are optionally substituted with one to three R 10 ; R i  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  hydroxyalkyl, C 1 -C 6  haloalkyl, \u2014(CH 2 ) q N(H)C 1 -C 6  alkyl, \u2014(CH 2 ) q N(C 1 -C 6  alkyl) 2 , \u2014(CR k R l ) m C 3 -C 7  cycloalkyl, \u2014(CR k R l ) m aryl, \u2014(CR k R l ) m heteroaryl, or \u2014(CR k R l ) m heterocycloalkyl, wherein alkyl, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R 11 ; R k  and R l  are each independently at each occurrence selected from H, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, or halogen; each m and n is independently at each occurrence 0, 1, or 2; each q is independently at each occurrence 1, 2, 3 or 4; and s is 1, 2, 3, 4, or 5.

Metadata:
- Claim Count in Document: 83.0
- Percentile: 95.0
- Lexical Diversity: 1.39535
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14546896', '14546775', '15937271', '14982127', '14720323']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8322820316663265
- 35 USC 102 Novelty (BERT): 0.6805912110255681
- Combined Prediction Score: 0.8171129496022508
- Mean Citation Score: 459.830116
- Max Citation Score: 708.1897
- Similarity Product: 700.3591062318028

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test