PATENT CLAIM ANALYSIS

Application Number: 16025624
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["424", "186100"]

Abstract:
The present invention relates to attenuated, immunogenic  West Nile virus  chimeras built on a  dengue virus  backbone for the production of immunogenic, live, attenuated  West Nile virus  vaccines.

Claim (Index 1):
A nucleic acid chimera comprising a first nucleotide sequence encoding two structural protein from a  West Nile virus,  wherein the structural proteins are premembrane/membrane (prM) and envelope (E), and a second nucleotide sequence encoding capsid (C) and nonstructural proteins from a dengue type 1 virus dengue type 2 virus, or dengue type 3 virus, wherein the  dengue virus  is attenuated by a deletion of about 30 nucleotides from the 3\u2032 untranslated region of the dengue genome corresponding to the TL2 stem-loop structure and wherein a cleavage site is utilized for joining the  dengue virus  capsid protein and the  West Nile virus  prM protein, and wherein the  West Nile virus  prM protein contains aspartic acid (Asp) at a position 3 amino acids downstream of the cleavage site and contains threonine (Thr) at a position 6 amino acids downstream of the cleavage site.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 95.0
- Lexical Diversity: 1.33333
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14305572', '10871775', '13406153', '12990322', '11912482']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8013313300793721
- 35 USC 102 Novelty (BERT): 0.6511675039607564
- Combined Prediction Score: 0.7863149474675105
- Mean Citation Score: 508.6713820000001
- Max Citation Score: 629.3731
- Similarity Product: 616.5262062229872

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test