PATENT CLAIM ANALYSIS

Application Number: 15986577
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "364000"]

Abstract:
Use of glu-tubulin as a biomarker for predicting the response to a compound, preferably resistance of a disease such as cancer in a subject to said compound, wherein the compound is a furazanobenzimidazole compound of general formula (I).

Claim (Index 26):
A method of determining whether a subject is resistant to treating a disease by administration to said subject a compound of formula I wherein R represents phenyl, thienyl or pyridinyl wherein phenyl is optionally substituted by one or two substituents independently selected from alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, cyano, halogen, and nitro; and wherein two adjacent substituents are methylenedioxy; and wherein pyridinyl is optionally substituted by lower alkoxy, amino or halogen; wherein Y is oxygen or nitrogen substituted by hydroxy or lower alkoxy; or when R 1  is phenyl or pyridinyl, X is additionally oxygen, R 1  represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl; R 2 , R 3  and R 6  represent hydrogen; R 4  and R 5 , independently of each other, represent hydrogen, lower alkyl or lower alkoxy; or R 4  and R 5  together represent methylenedioxy; wherein said prefix denotes a radical having up to 7 carbon atoms; or pharmaceutically acceptable derivatives thereof; said method comprising;\n (a) obtaining a sample from said subject; \n (b) measuring the level of the glu-tubulin proteins in said sample; and \n (c) thereby determining from said measured level of the glu-tubulin proteins whether the subject is resistant to treating of said disease with said compound of formula I.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 1.43333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13980208', '13983887', '15294157', '13979955', '14005680']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8443066625506024
- 35 USC 102 Novelty (BERT): 0.6957582204293052
- Combined Prediction Score: 0.8294518183384727
- Mean Citation Score: 686.2745000000001
- Max Citation Score: 729.4968
- Similarity Product: 705.6618631502151

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test