PATENT CLAIM ANALYSIS

Application Number: 16032772
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["435", "252300"]

Abstract:
The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis/trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.

Claim (Index 41):
A method for producing muconate, comprising culturing a non-naturally occurring microbial organism having a muconate pathway, said pathway comprising at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate, under conditions and for a sufficient period of time to produce muconate, said muconate pathway comprising an enzyme selected from the group consisting of an HODH aldolase, an OHED hydratase, an OHED decarboxylase, an HODH formate-lyase, an HODH dehydrogenase, an OHED formate-lyase, an OHED dehydrogenase, a 6-OHE dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA ligase, and a muconate reductase.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 95.0
- Lexical Diversity: 2.38028
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15383593', '14308292', '15325396', '13191375', '15263149']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.3395038295908365
- 35 USC 102 Novelty (BERT): 0.6736378912344173
- Combined Prediction Score: 0.3729172357551946
- Mean Citation Score: 570.90703
- Max Citation Score: 726.4557
- Similarity Product: 627.8633734169482

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test