PATENT CLAIM ANALYSIS

Application Number: 15895907
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-11
Patent Classification: ["424", "185100"]

Abstract:
The present invention claims an isolated nucleotide sequence characterized by encoding the PFR1 protein of  Leishmania infantum  or a fragment thereof. This PFR1 protein or a fragment thereof comprises at least a selected immunodominant epitope between the following group: SEQ ID No: 1, SEQ ID No: 2, SEQ ID No: 3, SEQ ID No: 4, SEQ ID No: 5, SEQ ID No: 6, SEQ ID No: 7 and SEQ ID No: 8, where the immunodominant epitope is able to induce an antigen-specific T cell cytotoxic immune response in an animal, against the kinetoplastids causing the leishmaniasis disease. The immunodominant epitopes are cytotoxic T-lymphocyte activators and they present a high binding affinity for A2 type MHC Class I molecule.

Claim (Index 19):
A method for clarifying or generating partial or total clearance of kinetoplastids causing leishmaniasis disease of the tissues in an infected animal, comprising use of an expression product of at least one nucleotide sequence selected from the group consisting of:\n a nucleotide sequence coding for the PFR1 protein of  Leishmania infantum  or a fragment thereof comprising at least one immunodominant epitope selected from the epitope group consisting of: SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8, wherein the immunodominant epitope is able to induce an antigen-specific T cell cytotoxic immune response against kinetoplastids causing leishmaniasis disease in an animal; a nucleotide sequence coding for the 1-595 amino acids of  Leishmania infantum  PFR1 protein, determined by the SEQ ID NO: 12, and comprising at least one immunodominant epitope able to induce an antigen-specific T cell cytotoxic immune response against kinetoplastids causing leishmaniasis disease in an animal; a nucleotide sequence coding for the 160-595 amino acids of  Leishmania infantum  PFR1 protein, determined by the SEQ ID NO: 9, and comprising at least one immunodominant epitope able to induce an antigen-specific T cell cytotoxic immune response against kinetoplastids causing leishmaniasis disease in an animal; a nucleotide sequence coding for the 160-548 amino acids of  Leishmania infantum  PFR1 protein, determined by the SEQ ID NO: 10, and comprising at least one immunodominant epitope able to induce an antigen-specific T cell cytotoxic immune response against kinetoplastids causing leishmaniasis disease in an animal; and a nucleotide sequence coding for the 160-385 amino acids of  Leishmania infantum  PFR1 protein, determined by the SEQ ID NO: 11, and comprising at least one immunodominant epitope able to induce an antigen-specific T cell cytotoxic immune response against kinetoplastids causing leishmaniasis disease in an animal.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 88.0
- Lexical Diversity: 1.74684
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14234075', '13469636', '12149841', '14780504', '14288361']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6818398325640611
- 35 USC 102 Novelty (BERT): 0.7564613666814098
- Combined Prediction Score: 0.6893019859757961
- Mean Citation Score: 474.7210539999999
- Max Citation Score: 1011.5331
- Similarity Product: 849.9254488157809

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test