PATENT CLAIM ANALYSIS

Application Number: 16066697
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "275000"]

Abstract:
Compounds represented by Formula I are disclosed herein, wherein R, Ra and R 1 -R 14  are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.

Claim (Index 30):
A method of treating a disease or disorder associated with aggregation-prone proteins, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound represented by Formula I: or a pharmaceutically acceptable salt thereof, wherein:\n R 2  is H; \n R 1  is OH; \n R is OH or OR\u2032; \n R\u2032 is selected from the group consisting of alkyl, cycloalkyl, heteroalicyclic, aryl and heteroaryl; \n R 3  and R 4  are each hydrogen; \n Ra is alkyl; \n R 5 -R 14  are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, sulfonate, sulfoxide, thiosulfate, sulfate, sulfite, thiosulfite, phosphonate, thiohydroxy, thioalkoxy, cyano, nitro, azo, sulfonamide, carbonyl, thiocarbonyl, C-carboxylate, O-carboxylate, N-thiocarbamate, O-thiocarbamate, acyl halide, azide, urea, thiourea, N-carbamate, O-carbamate, C-amide, N-amide, hydrazine and hydrazide, \n with the proviso that when R is OR\u2032, and R\u2032 is methyl, R 7  and R 12  are each other than bromo, \n thereby treating a disease or disorder associated with aggregation-prone proteins.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 1.38462
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14849428', '15614278', '14436387', '13770676', '13770706']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7058943711904418
- 35 USC 102 Novelty (BERT): 0.5004608061521097
- Combined Prediction Score: 0.6853510146866086
- Mean Citation Score: 251.687206
- Max Citation Score: 259.42258
- Similarity Product: 214.1730578170335

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test