PATENT CLAIM ANALYSIS

Application Number: 15936097
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["435", "001100"]

Abstract:
Methods for treating a bioprosthetic tissue are described. The methods comprise contacting the biological tissue with an anchor compound, the anchor compound comprising first and second functional groups. The first functional group is reactive with and couples a tissue functional group associated with the biological tissue. The second functional group is one of a bio-orthogonal binding pair. The biological tissue coupled to the anchor compound is then exposed to a linking compound. The linking compound comprises at least two functional groups, each comprising the other one of the bio-orthogonal binding pair. In a preferred embodiment, the bio-orthogonal binding pair is an azide and an acetylene. The method can be performed in the presence of a catalyst, preferably a copper catalyst. Alternatively, the method can be performed in the absence of a catalyst, wherein the acetylene is incorporated in a ring-strained cyclic compound, such as cyclooctyne.

Claim (Index 1):
A method for cross-linking biological tissue comprising:\n contacting the biological tissue with an anchor compound, the anchor compound comprising first and second functional groups, the first functional group coupling a tissue functional group associated with the biological tissue and the second functional group being one of a bio-orthogonal binding pair; and exposing the biological tissue to a linking compound, the linking compound comprising at least two functional groups, the two functional groups each comprising the other one of the bio-orthogonal binding pair.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 90.0
- Lexical Diversity: 2.3
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14078435', '09933680', '14485576', '14074379', '12135507']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5870151843619161
- 35 USC 102 Novelty (BERT): 0.5316598898349831
- Combined Prediction Score: 0.5814796549092228
- Mean Citation Score: 218.289644
- Max Citation Score: 363.66672
- Similarity Product: 351.45017262657166

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test