PATENT CLAIM ANALYSIS

Application Number: 16218122
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["514", "211090"]

Abstract:
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , Y 3 , and Y 4  are described herein.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: X 1  is \u2014NR 3;  X 2  is C\u2550O, and X 4  is CR 1 R 2 ; X 3  is CR 1\u2032 R 2\u2032 ; Y 1 and Y 4  are not bonded to \u2014C(O)NHOH and are each CR 1 ; Y 2  and Y 3  are each CR 1  when not bonded to \u2014C(O)NHOH and Y 2  and Y 3  are C when bonded to \u2014C(O)NHOH; L is selected from a group consisting of a bond, \u2014(CR 1 R 2 ) n \u2014, \u2014C(O)O\u2014, \u2014C(O)NR 3 \u2014, \u2014S(O) 2 \u2014, \u2014S(O) 2 NR 3 \u2014, \u2014S(O)\u2014, and \u2014S(O)NR 3 \u2014, wherein L is bound to the ring nitrogen through the carbonyl or sulfonyl group; R is independently selected from the group consisting of \u2014H, \u2014C 1 -C 6  alkyl, \u2014C 2 -C 6  alkenyl, \u2014C 4 -C 8  cycloalkenyl, \u2014C 2 -C 6  alkynyl, \u2014C 3 -C 8  cycloalkyl, \u2014C 5 -C 12  spirocyclyl, heterocyclyl, spiroheterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocyclyl, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of \u2014OH, halogen, oxo, \u2014NO 2 , \u2014CN, \u2014R 1 , \u2014R 2 , \u2014OR 3 , \u2014NHR 3 , \u2014NR 3 R 4 , \u2014S(O) 2 NR 3 R 4 , \u2014S(O) 2 R 1 , \u2014C(O)R 1 , \u2014CO 2 R 1 , \u2014NR 3 S(O) 2 R 1 , \u2014S(O)R 1 , \u2014S(O)NR 3 R 4 , \u2014NR 3 S(O)R 1 , heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; each R 1  and R 2  are independently, and at each occurrence, selected from the group consisting of \u2014H, \u2014R 3 , \u2014R 4 , \u2014C 1 -C 6  alkyl, \u2014C 2 -C 6  alkenyl, \u2014C 4 -C 8  cycloalkenyl, \u2014C 2 -C 6  alkynyl, \u2014C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, \u2014OH, halogen, \u2014NO 2 , \u2014CN, \u2014NHC 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 N(C 1 -C 6  alkyl) 2 , \u2014N(C 1 -C 6  alkyl)S(O) 2 R 5 , \u2014S(O) 2 (C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6  alkyl, \u2014CO 2 C 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl)S(O) 2 C 1 -C 6  alkyl, and \u2014(CHR 5 )NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 5 , \u2014OR 3 , \u2014NHR 3 , \u2014NR 3 R 4 , \u2014S(O) 2 N(R 3 ) 2 , \u2014S(O) 2 R 5 , \u2014C(O)R 5 , \u2014CO 2 R 5 , \u2014NR 3 S(O) 2 R 5 , \u2014S(O)R 5 , \u2014S(O)NR 3 R 4 , \u2014NR 3 S(O)R 5 , heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; R 1\u2032  and R 2\u2032  are independently, and at each occurrence, selected from the group consisting of \u2014H, \u2014C 1 -C 6  alkyl, \u2014C 2 -C 6  alkenyl, \u2014C 4 -C 8  cycloalkenyl, \u2014C 2 -C 6  alkynyl, \u2014C 3 -C 8  cycloalkyl, heterocyclyl, \u2014OH, halogen, \u2014NO 2 , \u2014CN, \u2014NHC 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 N(C 1 -C 6  alkyl) 2 , \u2014N(C 1 -C 6 alkyl)S(O) 2 R 5 , \u2014S(O) 2 (C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6  alkyl, \u2014CO 2 C 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl)S(O) 2 C 1 -C 6  alkyl, and \u2014(CHR 5 ) n NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocyclyl is optionally substituted with one or more substituents selected from the group consisting of \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 5 , \u2014OR 3 , \u2014NHR 3 , \u2014NR 3 R 4 , \u2014S(O) 2 N(R 3 ) 2 , \u2014S(O) 2 R 5 , \u2014C(O)R 5 , \u2014CO 2 R 5 \u2014NR 3 S(O) 2 R 5 , \u2014S(O)R 5 , \u2014S(O)NR 3 R 4 , \u2014NR 3 S(O)R 5 , heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; R 3  and R 4  are independently, at each occurrence, selected from the group consisting of \u2014H, \u2014C 1 -C 6  alkyl, \u2014C 2 -C 6  alkenyl, \u2014C 4 -C 8  cycloalkenyl, \u2014C 2 -C 6  alkynyl, \u2014C 3 -C 8  cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, \u2014S(O) 2 N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 (C 1 -C 6  alkyl), \u2014(C 1 -C 6 alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6  alkyl, \u2014CO 2 C 1 -C 6  alkyl, or \u2014(CHR 5 )N(C 1 -C 6 alkyl) 2 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 5 , \u2014O(C 1 -C 6  alkyl), \u2014NH(C 1 -C 6  alkyl), \u2014N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 NH(C 1 -C 6  alkyl), \u2014C(O)C 1 -C 6  alkyl, \u2014CO 2 C 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl)S(O) 2 C 1 -C 6  alkyl, \u2014S(O)R 5 , \u2014S(O)N(C 1 -C 6 alkyl) 2 , \u2014N(C 1 -C 6 alkyl)S(O)R 5 , heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O; or R 3  and R can combine with the nitrogen atom to which they are attached to form a heterocycle, wherein each heterocycle or heteroaryl is optionally substituted by \u2014R 1 , \u2014R 2 , \u2014R 4 , \u2014OR 4 , or \u2014NR 4 R 5 ; R 5  is independently, and at each occurrence, selected from the group consisting of \u2014H, \u2014C 1 -C 6  alkyl, \u2014C 2 -C 6  alkenyl, \u2014C 4 -C 8  cycloalkenyl, \u2014C 2 -C 6  alkynyl, \u2014C 3 -C 8  cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, \u2014OH, halogen, \u2014NO 2 , \u2014CN, \u2014NHC 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 NH(C 1 -C 6  alkyl), \u2014S(O) 2 N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 C 1 -C 6  alkyl, \u2014C(O)C 1 -C 6  alkyl, \u2014CO 2 C 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl)SO 2 C 1 -C 6  alkyl, \u2014S(O)(C 1 -C 6  alkyl), \u2014S(O)N(C 1 -C 6  alkyl) 2 , \u2014N(C 1 -C 6  alkyl)S(O)(C 1 -C 6  alkyl), and \u2014(CH 2 ) n N(C 1 -C 6 alkyl) 2 ; and n is independently, and at each occurrence, an integer from 0 to 6.

Metadata:
- Claim Count in Document: 49.0
- Percentile: 98.0
- Lexical Diversity: 1.47826
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15013820', '15013814', '15013816', '16218126', '15013826']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8308743474094259
- 35 USC 102 Novelty (BERT): 0.5937363426294565
- Combined Prediction Score: 0.8071605469314289
- Mean Citation Score: 476.19844400000005
- Max Citation Score: 488.61356
- Similarity Product: 479.2679885351586

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test