PATENT CLAIM ANALYSIS

Application Number: 15746473
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["424", "186100"]

Abstract:
The present invention relates to the formulation of Adenoviral vectors in an aqueous mixture or freeze dried composition in the presence of amorphous sugar and low salt concentration, its formulation as well as a method for obtaining the dried composition.

Claim (Index 75):
A method of making a composition comprising an adenoviral vector comprising the steps of:\n a. providing an aqueous mixture comprising the adenoviral vector and a cryoprotectant that is an amorphous sugar selected from one or more of trehalose, sucrose, lactose, raffinose, dextran and mannitol, and b. lyophilizing the aqueous mixture by\n i. freezing the aqueous mixture by a process comprising the steps:\n 1. freezing the aqueous mixture by reducing the temperature to below Tg\u2032 of the mixture, \n 2. applying an annealing step to the frozen mixture by elevating the temperature without melting the frozen mixture and \n 3. reducing the temperature again to below Tg\u2032; then \n \n ii. drying the frozen aqueous mixture under reduced pressure.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 86.0
- Lexical Diversity: 1.23529
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['09941296', '13637817', '15355691', '13012714', '12531902']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6916568639002362
- 35 USC 102 Novelty (BERT): 0.4959161770841416
- Combined Prediction Score: 0.6720827952186267
- Mean Citation Score: 171.87401200000005
- Max Citation Score: 194.47939
- Similarity Product: 125.06047310200212

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test