PATENT CLAIM ANALYSIS

Application Number: 15761754
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["544", "249000"]

Abstract:
This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.

Claim (Index 22):
A process for the preparation of a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein R 1  is C 1-6  alkyl, or C 6-10  aryl. comprising introducing an alcohol protecting group (APG) onto a compound of Formula 8 to make a compound of Formula 9: coupling the compound of Formula 9 with a compound of Formula 10 in the presence of a first palladium catalyst complex to make a compound of Formula 11, wherein X is a metal-containing moiety and Y is a leaving group, alkylating the compound of structural Formula 11 using a alkylating reagent to provide a compound of Formula 12: by way of step (1) or step (2) wherein: step (1) comprises adding the alkylating reagent to the reaction mixture comprising the compound of Formula 11 without further isolation to make a compound of Formula 12, or step (2) comprises isolating the compound of Formula 11 and reacting it with the alkylating reagent in the presence of a first palladium catalyst complex to provide a compound of Formula 12, and deprotecting the alcohol protecting group in the compound of Formula 12 and isolating a compound of Formula I.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 90.0
- Lexical Diversity: 1.49091
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13704259', '13703983', '13825137', '13805346', '14117265']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7115207787720574
- 35 USC 102 Novelty (BERT): 0.4937557363163801
- Combined Prediction Score: 0.6897442745264898
- Mean Citation Score: 195.878918
- Max Citation Score: 200.08705
- Similarity Product: 137.36390076382756

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test