PATENT CLAIM ANALYSIS

Application Number: 15870663
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "044000"]

Abstract:
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.

Claim (Index 5):
The method of  claim 4  wherein the transgene encoding a rearranged human immunoglobulin variable region comprises a human germline light chain V gene segment joined to a human germline light chain J gene segment, wherein there is no mutation due to said joining and wherein said immunoglobulin constant region is a light chain constant region,\n so that said transgenic animal, in response to said antigen, has produced B cells that secrete antibodies with immunoglobulin light chains comprising said rearranged human light chain variable region and light chain constant region, paired with a diversity of immunoglobulin heavy chains, which antibodies bind said antigen.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 1.56452
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14266540', '13750753', '14265046', '15140321', '10577061']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4129774777652457
- 35 USC 102 Novelty (BERT): 0.6797689607349474
- Combined Prediction Score: 0.4396566260622159
- Mean Citation Score: 707.2358740000003
- Max Citation Score: 842.716
- Similarity Product: 636.3154728674889

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test