PATENT CLAIM ANALYSIS

Application Number: 16009904
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "130100"]

Abstract:
Methods for detecting a cardiac condition in a human subject are provided according to aspects of the present invention which include providing an immunological reagent characterized by specific binding to: an N-terminal fragment of human cardiac troponin T (HcTnT-N69) or a neoepitope of human cardiac troponin T generated by removal of HcTnT-N69 from HcTnT (HcTnT-neo); contacting the immunological reagent with a biological sample of the human subject under binding conditions; and detecting binding of the immunological reagent with HcTnT-N69 or HcTnT-neo, wherein detection of HcTnT-N69 or HcTnT-neo in the biological sample is indicative of a cardiac condition in the subject. Antibodies and antigen binding fragments thereof characterized by specific binding to HcTnT-N69 or HcTnT-neo, or a variant of either thereof, are provided according to aspects of the present invention.

Claim (Index 13):
The isolated antibody or antigen binding fragment thereof of  claim 11 , wherein the isolated antibody or antigen binding fragment thereof is an isolated monoclonal antibody or antigen binding fragment thereof, and wherein the isolated monoclonal antibody or antigen binding fragment thereof comprises: 1) a Variable Heavy region (VH) comprising amino acid sequence SEQ ID NO:2, or a variant thereof; and a Variable Light region (VL) comprising amino acid sequence SEQ ID NO:30; 2) a VH region comprising amino acid sequence SEQ ID NO:8, or a variant thereof; and a VL region comprising amino acid sequence SEQ ID NO:30; and 3) a VH region comprising amino acid sequence SEQ ID NO:12, or a variant thereof; and a VL region comprising amino acid sequence SEQ ID NO:30.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 94.0
- Lexical Diversity: 2.2381
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13641315', '13554780', '16004795', '13288587', '14359864']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.731473721484878
- 35 USC 102 Novelty (BERT): 0.5503473914747987
- Combined Prediction Score: 0.7133610884838701
- Mean Citation Score: 398.24379
- Max Citation Score: 408.1468
- Similarity Product: 310.0022722578287

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test