PATENT CLAIM ANALYSIS

Application Number: 15884052
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["514", "043000"]

Abstract:
Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus infection with one or more nucleosides, nucleotides and nucleotide analogs.

Claim (Index 1):
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: B 1A  is an optionally substituted heterocyclic base or an optionally substituted heterocyclic base with a protected amino group; R A  is hydrogen or deuterium; R 1A  is selected from the group consisting of hydrogen, an optionally substituted acyl, an optionally substituted O-linked amino acid, R a1  and R a2  are independently hydrogen or deuterium; R 2A  is an unsubstituted C 1-4  alkyl, an unsubstituted C 2-4  alkenyl, an unsubstituted C 2-4  alkynyl, a C 1-6  haloalkyl, a C 1-6  azidoalkyl or a C 1-6  aminoalkyl; R 3A  is selected from the group consisting of hydrogen, deuterium, halo, OH, \u2014OC(\u2550O)R\u2032 A  and an optionally substituted O-linked amino acid; R 4A  is hydrogen or deuterium; R 5A  is hydrogen, deuterium, halogen, N 3 , OH, an optionally substituted C 1-6  alkyl, an optionally substituted C 2-6  alkenyl and an optionally substituted C 2-6  alkynyl; R 6A , R 7A  and R 8A  are independently selected from the group consisting of absent, hydrogen, an optionally substituted C 1-24  alkyl, an optionally substituted C 3-24  alkenyl, an optionally substituted C 3-24  alkynyl, an optionally substituted C 3-6  cycloalkyl, an optionally substituted C 3-6  cycloalkenyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aryl(C 1-6  alkyl), an optionally substituted *\u2014(CR 15A R 16A ) p \u2014O\u2014C 1-24  alkyl, an optionally substituted *\u2014(CR 17A R 18A ) q \u2014O\u2014C 1-24  alkenyl, R 6A  is and R 7A  is absent or hydrogen; or\n R 6A  and R 7A  are taken together to form a moiety selected from the group consisting of an optionally substituted \n and an optionally substituted wherein the oxygens connected to R 6A  and R 7A , the phosphorus and the moiety form a six-membered to ten-membered ring system;\n R 9A  is independently selected from the group consisting of an optionally substituted C 1-24  alkyl, an optionally substituted C 2-24  alkenyl, an optionally substituted C 2-24  alkynyl, an optionally substituted C 3-6  cycloalkyl, an optionally substituted C 3-6  cycloalkenyl, NR 31A R 32A  an optionally substituted N-linked amino acid and an optionally substituted N-linked amino acid ester derivative; \n R 10A  and R 11A  are independently an optionally substituted N-linked amino acid or an optionally substituted N-linked amino acid ester derivative; \n R 12A  and R 13A  are independently absent or hydrogen; \n R 14A  is O\u2014, OH or methyl; \n each R 15A , each R 16A , each R 17A  and each R 18A  are independently hydrogen, an optionally substituted C 1-24  alkyl or alkoxy; \n R 19A , R 20A , R 22A  and R 23A  are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24  alkyl and an optionally substituted aryl; \n R 21A  and R 24A  are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24  alkyl, an optionally substituted aryl, an optionally substituted \u2014O\u2014C 1-24  alkyl, an optionally substituted \u2014O-aryl an optionally substituted \u2014O-heteroaryl, an optionally substituted \u2014O-monocyclic heterocyclyl and \n R 25A , R 26A  and R 30A  are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24  alkyl and an optionally substituted aryl; R 27A  and R 28A  are independently \u2014C\u2261N or an optionally substituted substituent selected from the group consisting of C 2-8  organylcarbonyl, C 2-8  alkoxycarbonyl and C 2-8  organylaminocarbonyl; R 29A  is selected from the group consisting of hydrogen, an optionally substituted C 1 -24 alkyl, an optionally substituted C 2-24  alkenyl, an optionally substituted C 2-24  alkynyl, an optionally substituted C 3-6  cycloalkyl and an optionally substituted C 3-6  cycloalkenyl; R 31A  and R 32A  are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24  alkyl, an optionally substituted C 2-24  alkenyl, an optionally substituted C 2-24  alkynyl, an optionally substituted C 3-6  cycloalkyl, an optionally substituted C 3-6  cycloalkenyl and an optionally substituted aryl(C 1-4  alkyl); R\u2033 A  is an optionally substituted C 1-24  alkyl; m and t are independently 0 or 1; p and q are independently selected from the group consisting of 1, 2 and 3; s is 0, 1, 2 or 3; r and u are independently 1 or 2; y is 3, 4 or 5; and Z 1A , Z 2A , Z 3A  and Z 4A  are independently O or S.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 86.0
- Lexical Diversity: 1.35714
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14971926', '15790764', '15215434', '15423270', '14746500']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8270645382688853
- 35 USC 102 Novelty (BERT): 0.5130727983255733
- Combined Prediction Score: 0.7956653642745541
- Mean Citation Score: 311.318934
- Max Citation Score: 331.3129600000001
- Similarity Product: 325.79568383478176

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test