PATENT CLAIM ANALYSIS

Application Number: 15781848
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "300000"]

Abstract:
The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apneas and central sleep apneas and snoring.

Claim (Index 5):
A method for preparing a compound of the formula (I) as defined in  claim 1 , characterized in that a compound of the formula (II) in which R 1  is as defined in  claim 1 , is reacted in the presence of a suitable reducing agent either [A] with a compound of the formula (III) in which R 2  is as defined in  claim 1 , to give a compound of the formula (I) or [B] with a protected perhydropyrrolo[3,4-c]pyrrole of the formula (IV) in which PG represents a suitable amino protecting group at first to give a compound of the formula (V) in which PG is as defined for the compound of formula (IV) and R 1  is as defined in  claim 1 , then the protecting group PG is cleaved and the resulting compound of the formula (VI) in which R 1  is as defined in  claim 1 , is then reacted, depending on the specific definition of the R 2  radical, [B-1] with a carboxylic acid of the formula (VII) in which R 2A  represents (C 4 -C 6 )-cycloalkyl in which a ring CH 2  group may be replaced by \u2014O\u2014, or is a phenyl group of the formula (a) or a pyridyl group of the formula (b), as described in  claim 1 ,\n with activation of the carboxylic acid function in (VII), or is reacted with the corresponding acid chloride of the formula (VIII) \n in which R 2A  is as defined above, to give a compound of the formula (I-A) in which R 1  is as defined in  claim 1  and R 2A  is as defined above, or is reacted [B-2] with a chloroformate or carbamoyl chloride of the formula (IX) in which R 2B  represents the \u2014OR 7  or \u2014NR 8 R 9A  group in which\n R 7  and R 8  are as defined in  claim 1 \n and \n R 9A  has the definition of R 9  as defined in  claim 1 , but is not hydrogen, \n to give a compound of the formula (I-B) \n in which R 1  is as defined in  claim 1  and R 2B  is as defined above have the definitions specified above, or is reacted [B-3] with an isocyanate of the formula (X)\n R 8 \u2014N\u2550C\u2550O\u2003\u2003(X) \n in which R 8  is as defined in  claim 1 \n to give a compound of the formula (I-C) \n in which R 1  and R 8  are as defined in  claim 1 , and the resulting compound of the formulae (I), (I-A), (I-B) or (I-C) is optionally converted with the appropriate (i) solvent and/or (ii) acid into its solvate, salt and/or solvate of the salt.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 94.0
- Lexical Diversity: 1.66
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15027519', '15735138', '14895793', '13819337', '13945675']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.77290872429055
- 35 USC 102 Novelty (BERT): 0.533717651760664
- Combined Prediction Score: 0.7489896170375614
- Mean Citation Score: 325.011188
- Max Citation Score: 333.57864
- Similarity Product: 222.23149570043563

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test