PATENT CLAIM ANALYSIS

Application Number: 15873255
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "313000"]

Abstract:
Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

Claim (Index 10):
The compound according to  claim 1  that is:\n S,S\u2032-(2-((4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)carbamoyl)propane-1,3-diyl)diethanethioate; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-mercapto-2-(mercaptomethyl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-3-carboxamide; \n S,S\u2032-(2-((4-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)carbomoyl)propane-1,3-diyl)diethanethioate; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-mercapto-2-(mercaptomethyl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide; \n N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide; \n N-(4-(3-chloro-4-((3-fluorobenzyloxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1-oxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,2-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2-trioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2,2-tetroxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1,2-trioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2,2-trioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1,2,2-tetroxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-3-yl)butanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-sulfonamide 1-oxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-sulfonamide 1,1-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-3-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1-oxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,1-dioxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(2,2-dioxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,2-dithiolan-4-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-3-yl)ethane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-4-yl)ethane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-3-yl)propane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-4-yl)propane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-3-yl)butane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-4-yl)butane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1-oxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,2-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2-trioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2,2-tetroxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1,2-trioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2,2-trioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1,2,2-tetroxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-4-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-3-yl)butanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-4-yl)butanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-5-(1,2-dithiolan-4-yl)pentanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide 1-oxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide 1,1-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-3-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1-oxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(2-oxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,1-dioxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(2,2-dioxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,2-dithiolan-4-yl)methanesulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-3-yl)ethane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-4-yl)ethane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-4-yl)propane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-3-yl)butane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-4-yl)butane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1-oxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,2-dioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1-dioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2-trioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2,2-tetraoxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1,2-trioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2,2-trioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1,2,2-tetraoxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-4-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-3-yl)butanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-4-yl)butanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1-oxido-1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(2-oxido-1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2-dioxido-1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,1-dioxido-1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(2,2-dioxido-1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,1,2-trioxido-1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2,2-trioxido-1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,1,2,2-tetraoxido-1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-3-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1-oxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(2-oxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,1-dioxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(2,2-dioxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-3-yl)ethanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-4-yl)ethanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-3-yl)propane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-4-yl)propane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-3-yl)butane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-4-yl)butane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1-oxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,2-dioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1-dioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2-trioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2,2-tetroxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1,2-trioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2,2-trioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1,2,2-tetroxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-4-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-3-yl)butanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-4-yl)butanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-4-yl)pentanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide 1-oxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide 1,1-dioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-3-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1-oxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(2-oxido-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,1-dioxo-1,2-dithiolan-3-yl)methanesulfonamide \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(2,2-dioxo-1,2-dithiolan-3-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,2-dithiolan-4-yl)methanesulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-3-yl)ethane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-4-yl)ethane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-4-yl)propane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-3-yl)butane-1-sulfonamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-4-yl)butane-1-sulfonamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide-1-oxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide-1,1-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide-2-oxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide-2,2-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1-oxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(2-oxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1,1-dioxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(2,2-dioxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide-1-oxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide-1,1-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide-2-oxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide-2,2-dioxide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1-oxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(2-oxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1,1-dioxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(2,2-dioxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide-1-oxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide-1,1-dioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide-2-oxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide-2,2-dioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1-oxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(2-oxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1,1-dioxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(2,2-dioxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide-1-oxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide-1,1-dioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide-2-oxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide-2,2-dioxide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1-oxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(2-oxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1,1-dioxido-1,2-dithiolan-3-yl)propanamide; \n N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(2,2-dioxido-1,2-dithiolan-3-yl)propanamide; \n or a pharmaceutically acceptable form thereof.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 86.0
- Lexical Diversity: 1.15385
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15873293', '13354556', '12429014', '11169312', '15319637']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7442707030068347
- 35 USC 102 Novelty (BERT): 0.5559859299180235
- Combined Prediction Score: 0.7254422256979537
- Mean Citation Score: 284.493394
- Max Citation Score: 412.86075
- Similarity Product: 300.2707148386985

Labels:
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- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test