PATENT CLAIM ANALYSIS

Application Number: 16066574
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "234500"]

Abstract:
A novel class of fluorinated derivatives of Formula (I) have been prepared and found to be useful in the treatment of cancers and other EGFR related disorders.

Claim (Index 25):
The compound of  claim 1 , selected from:\n N-[4-(3,4-dichloro-2-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]prop-2-enamide; (E)-N-[4-(3,4-dichloro-2-fluoro-anilino)-7-[2-(difluoromethoxy) ethoxy]-quinazolin-6-yl]-4-(dimethylamino)but-2-enamide; (E)-N-[4-(3,4-dichloro-2-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]-quinazolin-6-yl]-4-morpholino-but-2-enamide; (E)-N-[4-(3-chloro-2-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide; (E)-N-[4-(3-chloro-2-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-(1-piperidyl)but-2-enamide; (E)-N-[4-(3-chloro-2-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-morpholino-but-2-enamide; (E)-N-[4-(3-chloro-2-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-[4-(difluoromethoxy)-1-piperidyl]but-2-enamide; (E)-N-[4-(3-chloro-2,4-difluoro-anilino)-7-[2-(difluoromethoxy) ethoxy]-quinazolin-6-yl]-4-(dimethylamino)but-2-enamide; (E)-N-[4-(3-chloro-2,4-difluoro-anilino)-7-[2-(difluoromethoxy) ethoxy]-quinazolin-6-yl]-4-(1-piperidyl)but-2-enamide; (E)-N-[4-(3-chloro-2,4-difluoro-anilino)-7-[2 (difluoromethoxy) ethoxy]-quinazolin-6-yl]-4-morpholino-but-2-enamide; (E)-N-[4-(3-chloro-2,4-difluoro-anilino)-7-[2 (difluoromethoxy) ethoxy]quinazolin-6-yl]-4-[4-(difluoromethoxy)-1-piperidyl]but-2-enamide; (E)-N-[4-(3,4-dichloro-2-fluoro-anilino)-7-[2-(difluoromethoxy)-ethoxy]quinazolin-6-yl]-4-(1-piperidyl)but-2-enamide; (E)-N-[4-(3,4-dichloro-2-fluoro-anilino)-7-[2-(difluoromethoxy) ethoxy]-quinazolin-6-yl]-4-[4-(difluoromethoxy)-1-piperidyl]-but-2-enamide; (E)-N-[4-(3-chloro-2-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-(3,3-difluoroazetidin-1-yl)but-2-enamide; (E)-N-[4-(3-chloro-2,4-difluoro-anilino)-7-[2-(difluoromethoxy)-ethoxy]quinazolin-6-yl]-4-(3,3-difluoroazetidin-1-yl)but-2-enamide; (E)-N-[4-(3,4-dichloro-2-fluoro-anilino)-7-methoxy-quinazolin-6-yl]-4-[4-(difluoromethoxy)-1-piperidyl]but-2-enamide; (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-methoxy-quinazolin-6-yl]-4-[4-(difluoromethoxy)-1-piperidyl]but-2-enamide; (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide; (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-(1-piperidyl)but-2-enamide; (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-morpholino-but-2-enamide; (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-[4-(difluoromethoxy)-1-piperidyl]but-2-enamide; (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-(3,3-difluoroazetidin-1-yl)but-2-enamide; (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[2-(difluoromethoxy)ethoxy]quinazolin-6-yl]-4-(4,4-difluoro-1-piperidyl)but-2-enamide; (E)-N-[7-[2-(difluoromethoxy)-ethoxy]-4-(3-ethynyl-2-fluoro-anilino)quinazolin-6-yl]-4-(dimethylamino)but-2-enamide; (E)-N-(4-(3-chloro-2-fluorophenoxy)-7-(2-(difluoromethoxy)ethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide; (E)-N-(4-(3-chloro-4-fluorophenoxy)-7-(2-(difluoromethoxy)ethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide; (E)-N-(4-(3-chloro-2-fluorophenoxy)-7-(2-(difluoromethoxy)ethoxy)quinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide; (E)-N-(4-(3-chloro-2-fluorophenoxy)-7-(2-(difluoromethoxy)ethoxy)quinazolin-6-yl)-4-morpholinobut-2-enamide; and (E)-N-(4-(3-chloro-2-fluorophenoxy)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide; or a pharmaceutically acceptable salt and/or hydrate thereof.

Metadata:
- Claim Count in Document: 25.0
- Percentile: 94.0
- Lexical Diversity: 1.11111
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14466896', '15359370', '14234514', '14002983', '14399510']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7828651883371088
- 35 USC 102 Novelty (BERT): 0.5074952962557417
- Combined Prediction Score: 0.7553281991289722
- Mean Citation Score: 272.126818
- Max Citation Score: 283.61575
- Similarity Product: 240.0100644287318

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test