PATENT CLAIM ANALYSIS

Application Number: 16179709
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "243000"]

Abstract:
The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.

Claim (Index 1):
A compound of formula 2: or a pharmaceutically acceptable salt thereof, wherein m is selected from 0, 1, and 2; n is selected from 0, 1, and 2; each R 1  is independently selected from the group consisting of cyano, halo, hydroxy, amino, C 1-4  alkyl, C 1-4  alkoxy, trifluoromethyl, and trifluoromethoxy; each R 4  is independently selected from the group consisting of cyano, halo, hydroxy, amino, C 1-4  alkyl, C 1-4  alkoxy, trifluoromethyl, fluoromethoxy, difluoromethoxy, and trifluoromethoxy; and R 5  is selected from the group consisting of hydrogen, trifluoromethyl, and C 1-4  alkyl, provided:\n (a) if R 5  is hydrogen, methyl, n-propyl, i-propyl, or i-butyl, then m and n are not both 0; \n (b) if R 5  is hydrogen, m is 0, and n is 1, then R 4  is not chloro, methoxy, 3-trifluoromethyl, 4-trifluoromethyl, 4-methyl, 4-fluoro, 2-difluoromethoxy, 3-difluoromethoxy, 2-trifluoromethoxy, 4-trifluoromethoxy, or 2-(i-butoxy); \n (c) if R 5  is methyl, m is 0, and n is 1, then R 4  is not chloro, 2-fluoro, 4-fluoro, 2-bromo, 4-ethyl, 2-methyl, 4-(i-propyl), 4-(i-butyl), or 3-trifluoromethyl; \n (d) if R 5  is ethyl, m is 0, and n is 1, then R 4  is not 3-chloro, 4-chloro, 4-bromo, 4-methyl, 4-methoxy, or 2-difluoromethoxy; \n (e) if R 5  is n-propyl, m is 0, and n is 1, then R 4  is not 3-trifluoromethyl; \n (f) if R 5  is i-propyl, m is 0, and n is 1, then R 4  is not 4-fluoro or 4-methoxy; \n (g) if R 5  is i-butyl, m is 0, and n is 1, then R 4  is not 3-trifluoromethyl; \n (h) if R 5  is hydrogen, m is 0, and n is 2, then R 4  is not 2,6-difluoro, 2,4-dichloro, 3,5-dimethoxy, 3,4-dimethoxy, 4-methoxy-3-difluoromethoxy, 4-fluoro-2-trifluoromethyl, or 5-bromo-2-difluormethoxy; and \n (i) if R 5  is methyl, m is 0, and n is 2, then R 4  is not 3,4-dimethyl, 3,4-dichloro, 2,4-dichloro, 3-fluoro-4-methoxy, 3-bromo-4-methoxy, 3-methoxy-4-isopropyloxy, or 3-methoxy-4-isobutyloxy.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 98.0
- Lexical Diversity: 1.35135
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14946194', '15683589', '15382490', '13509442', '13824174']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8642276941139831
- 35 USC 102 Novelty (BERT): 0.6608184588656
- Combined Prediction Score: 0.8438867705891449
- Mean Citation Score: 524.891476
- Max Citation Score: 645.68604
- Similarity Product: 641.7660984603452

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test