PATENT CLAIM ANALYSIS

Application Number: 15950863
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["506", "007000"]

Abstract:
Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients.

Claim (Index 10):
The method of  claim 9 , wherein the digital karyotyping analysis further comprises generating the genomic DNA tags using N1aIII and SacI restriction enzymes, wherein the genomic DNA tags are 17 bp genomic DNA tags, and further wherein sliding windows with tag density ratios greater than or equal to 6 are considered to represent amplified regions.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.32258
- Patent Class: 506.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14790833', '13339986', '14526344', '14466208', '11639712']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5804837586412833
- 35 USC 102 Novelty (BERT): 0.5663793696709121
- Combined Prediction Score: 0.5790733197442461
- Mean Citation Score: 285.68419
- Max Citation Score: 503.7
- Similarity Product: 309.79994341135017

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test