PATENT CLAIM ANALYSIS

Application Number: 15920690
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["548", "356100"]

Abstract:
The invention provides pyrazolyl guanidine compounds that inhibit F 1 F 0 -ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.

Claim (Index 45):
A method of treating psoriasis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of Formula I to treat the psoriasis: including all stereoisomers, geometric isomers, and tautomers; or a pharmaceutically acceptable salt or solvate of any of the foregoing; wherein: A 1  is phenylene; A 2  is R 1  represents independently for each occurrence halogen, haloalkyl, alkyl, cycloalkyl, heterocycloalkyl, hydroxyl, C 1 -C 6 alkoxy, cyano, \u2014CO 2 R 8 , \u2014C(O)R 9 , \u2014S(O)R 9 , \u2014SO 2 R 9 , \u2014SO 2 N(R 10 )(R 11 ), \u2014C(O)N(R 10 )(R 11 ), \u2014N(R 10 )(R 11 ), or \u2014N(R 8 )C(O)(R 9 ); R 2  is hydrogen or alkyl; R 3  is aryl, aralkyl, cycloalkyl, \u2014(C(R 8 ) 2 ) m -cycloalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, \u2014(C(R 8 ) 2 ) m -heterocycloalkyl, alkyl, haloalkyl, hydroxyalkyl, \u2014(C(R 8 ) 2 ) m -alkoxyl, \u2014(C(R 8 ) 2 ) m \u2014O\u2014(C(R 8 ) 2 ) m -alkoxyl, or \u2014(C(R 8 ) 2 ) m \u2014CN, wherein said aryl, aralkyl, cycloalkyl, heteroaryl, heteroaralkyl, and heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, hydroxyalkyl, C 1 -C 6 alkoxy, cyano, and \u2014C 1 -C 6 alkylene-CO 2 R 8 ; R 4  is hydrogen or alkyl; R 5  is hydrogen or alkyl; R 6  is alkyl, cycloalkyl, haloalkyl, cyano, aryl, aralkyl, heteroaryl, heteroaralkyl, \u2014CO 2 R 8 , or \u2014C(O)N(R 10 )(R 11 ), wherein said cycloalkyl, aryl, aralkyl, heteroaryl, and heteroaralkyl are each optionally substituted with 1 or 2 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, hydroxyalkyl, C 1 -C 6 alkoxy, \u2014O-aralkyl, and cyano; R 7  is hydrogen, halogen, alkyl, or haloalkyl; R 8  represents independently for each occurrence hydrogen, alkyl, or cycloalkyl; or two occurrences of R 8  attached to the same carbon atom are taken together with said carbon atom to form a saturated carbocylic ring; R 9  represents independently for each occurrence alkyl or cycloalkyl; R 10  and R 11  each represent independently for each occurrence hydrogen, alkyl, or cycloalkyl; or R 10  and R 11  are taken together with the nitrogen atom to which they are attached to form a 3 to 7 membered heterocyclic ring optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, and C 1 -C 6 alkoxy; n is 1, 2, or 3; and m is 1, 2, 3, 4, or 5.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 90.0
- Lexical Diversity: 1.24242
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15421729', '13992255', '14800969', '14403787', '15896378']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7575311959868896
- 35 USC 102 Novelty (BERT): 0.585922207350359
- Combined Prediction Score: 0.7403702971232365
- Mean Citation Score: 455.417124
- Max Citation Score: 484.4478
- Similarity Product: 447.109965358901

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test