PATENT CLAIM ANALYSIS

Application Number: 16171236
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "211100"]

Abstract:
The present invention relates to compounds of formula I wherein R 1 , R 2 , R 3 , R 4a , R 4b , R 4c , R 4d , L, A, Q, W and HET are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.

Claim (Index 50):
The method according to  claim 37 , wherein the compound of formula I is selected from any one of the following:\n (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[methyl(tetrahydrofuran-3-yl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[methyl(oxetan-3-yl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[methyl(tetrahydropyran-4-yl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)-1-[4-(azepan-1-ylmethyl)phenyl]-N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[(4-methyl-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[2-methoxyethyl(methyl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[(4-methyl-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-(2-cyclohexylethyl)-1,3,4-thiadiazol-2-yl]-1-[4-(1,4-oxazepan-4-ylmethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)-1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[5-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(diethylaminomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[2-methoxyethyl(methyl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(1,4-oxazepan-4-ylmethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[(4-hydroxy-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)-1-[4-(3-azabicyclo[3.1.0]hexan-3-ylmethyl)phenyl]-N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(1,4-oxazepan-4-ylmethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-1-[4-[(tetrahydropyran-4-ylamino)methyl]phenyl]pyrrolidine-3-carboxamide; N-[5-(2-cyclohexylethyl)-1,3,4-thiadiazol-2-yl]-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidine-3-carboxamide; N-[5-(2-cyclopentylethyl)-1,3,4-thiadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-fluorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[methyl(propyl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; 1-[4-(3-azabicyclo[3.1.0]hexan-3-ylmethyl)phenyl]-N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[methyl(tetrahydropyran-4-yl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[ethyl(isobutyl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-(2-cyclopentylethyl)-1,3,4-thiadiazol-2-yl]-1-[4-[(4-fluoro-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; 1-[4-(azepan-1-ylmethyl)phenyl]-N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-(2-cyclopentylethyl)-1,3,4-thiadiazol-2-yl]-1-[4-[(3,3-difluoro-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[(dipropylamino)methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; 1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[5-(2-phenylethyl)thiazol-2-yl]pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[(2S,6R)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[ethyl(propyl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-(2-cyclopentylethyl)-1,3,4-thiadiazol-2-yl]-1-[4-(1,4-oxazepan-4-ylmethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-(2-cyclopentylethyl)-1,3,4-thiadiazol-2-yl]-1-[4-[(4,4-difluoro-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[3-[2-(4-chlorophenyl)ethyl]-1H-pyrazol-5-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[(2S,6S)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[6-[2-(4-fluorophenyl)ethyl]pyridazin-3-yl]-1-[4-[[methyl(tetrahydropyran-4-yl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[ethyl(isopropyl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[1-[4-(1,4-oxazepan-4-ylmethyl)phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-1-[4-(morpholinomethyl)phenyl]pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3S)-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; N-[1-[4-(azepan-1-ylmethyl)phenyl]-5-oxo-pyrrolidin-3-yl]-5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3S)-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[1-[4-[(4-methyl-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3S)-1-[4-[(4-methyl-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-1-[4-[(4-methyl-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; N-[1-[4-(3-azabicyclo[3.1.0]hexan-3-ylmethyl)phenyl]-5-oxo-pyrrolidin-3-yl]-5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-5-oxo-1-[4-[(3-oxopiperazin-1-yl)methyl]phenyl]pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[1-[4-[[2-methoxyethyl(methyl)amino]methyl]phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]isoxazole-3-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]isoxazole-3-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3S)-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]isoxazole-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]isoxazol-3-yl]-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidine-3-carboxamide; N-[5-(2-cyclohexylethyl)-1,3,4-thiadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[6-[2-(4-fluorophenyl)ethyl]pyridazin-3-yl]-1-[4-[[methyl(tetrahydrofuran-3-yl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[6-[2-(4-fluorophenyl)ethyl]pyridazin-3-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-methoxyphenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-1-[4-(pyrrolidin-1-ylmethyl)phenyl]pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]isoxazol-3-yl]-1-[4-[[methyl(tetrahydrofuran-3-yl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; 4-[[[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]amino]methyl]-1-[4-(morpholinomethyl)phenyl]pyrrolidin-2-one; N-[5-[(4-fluorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[6-[2-(4-fluorophenyl)ethyl]pyridazin-3-yl]-1-[4-[[methyl(oxetan-3-yl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(1,4-diazepan-1-ylmethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; tert-butyl 4-[[4-[4-[[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]carbamoyl]-2-oxo-pyrrolidin-1-yl]phenyl]methyl]piperazine-1-carboxylate; 1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[5-(2-phenylethyl)isoxazol-3-yl]pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[[isopropyl(methyl)amino]methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-1-[4-(piperazin-1-ylmethyl)phenyl]pyrrolidine-3-carboxamide; (3R)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; 1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[6-(2-phenylethyl)pyridazin-3-yl]pyrrolidine-3-carboxamide; (3R)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidine-3-carboxamide; (3S)-5-oxo-1-[4-(1-piperidylmethyl)phenyl]-N-[5-(2-tetrahydropyran-2-ylethyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide; (3S)-1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[5-(2-tetrahydropyran-2-ylethyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide; N-[5-(2-cyclopentylethyl)-1,3,4-thiadiazol-2-yl]-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidine-3-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3S)-1-[4-(morpholinomethyl)phenyl]pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-fluorophenyl)ethyl]-N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-1-[4-[(4-hydroxy-4-methyl-1-piperidyl)methyl]phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-1-[4-[[(3-hydroxy-3-methyl-butyl)amino]methyl]phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide hydrochloride; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-1-[4-[[(3-hydroxy-3-methyl-butyl)-methyl-amino]methyl]phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-5-(2-phenylethyl)-1,3,4-thiadiazole-2-carboxamide; 5-[2-(4-fluorophenyl)ethyl]-N-[(3R)-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]isoxazole-3-carboxamide; 5-[2-(4-fluorophenyl)ethyl]-N-[(3S)-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]isoxazole-3-carboxamide; N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-5-(2-phenylethyl)isoxazole-3-carboxamide; 1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[5-(2-phenylethyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-[(dimethylamino)methyl]phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[6-[2-(4-fluorophenyl)ethyl]pyridazin-3-yl]-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidine-3-carboxamide; 1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[5-(2-phenylethyl)-1H-pyrazol-3-yl]pyrrolidine-3-carboxamide; (3S)\u2014N-[6-[2-(4-fluorophenyl)ethyl]pyridazin-3-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-(3-methylpentyl)-1,3,4-thiadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-(3-methylpentyl)-1,3,4-thiadiazol-2-yl]-5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidine-3-carboxamide; 4-[[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]methylamino]-1-[4-(morpholinomethyl)phenyl]pyrrolidin-2-one; N-[[4-[4-[[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]carbamoyl]-2-oxo-pyrrolidin-1-yl]phenyl]methyl]-1-methyl-piperidine-4-carboxamide; (3S)-1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[5-(2-tetrahydrofuran-2-ylethyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide; N-[5-(cyclohexoxymethyl)thiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; 1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[5-(2-tetrahydropyran-4-ylethyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide; 5-oxo-1-[4-(1-piperidylmethyl)phenyl]-N-[5-(2-tetrahydropyran-4-ylethyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide; (3S)-5-oxo-1-[4-(1-piperidylmethyl)phenyl]-N-[5-(2-tetrahydropyran-4-ylethyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide; (3S)-5-oxo-1-[4-(1-piperidylmethyl)phenyl]-N-[5-(2-tetrahydrofuran-2-ylethyl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-1-methyl-pyrazol-3-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-1-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-5-(2-phenylethyl)-1,3,4-oxadiazole-2-carboxamide; 5-[2-(2-furyl)ethyl]-N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 5-[(4-chlorophenyl)methylamino]-N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-5-(2-phenylethyl)thiazole-2-carboxamide; N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-3-(2-phenylethyl)isoxazole-5-carboxamide; N-[3-[2-(4-methoxyphenyl)ethyl]isoxazol-5-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; 1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[3-(2-phenylethyl)isoxazol-5-yl]pyrrolidine-3-carboxamide; 1-[4-(morpholinomethyl)phenyl]-5-oxo-N-[2-(2-phenylethyl)thiazol-5-yl]pyrrolidine-3-carboxamide; N-[5-[2-(4-chlorophenyl)ethyl]-2-methyl-pyrazol-3-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; 1-[4-(aminomethyl)phenyl]-N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-5-oxo-pyrrolidine-3-carboxamide; N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-3-(2-phenylethyl)-1H-pyrazole-5-carboxamide; N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-6-(2-phenylethyl)pyridazine-3-carboxamide; N-[5-oxo-1-[4-(1-piperidylmethyl)phenyl]pyrrolidin-3-yl]-2-(2-phenylethyl)thiazole-5-carboxamide; N-[5-[2-(4-methoxyphenyl)ethyl]-1,3,4-oxadiazol-2-yl]-1-[4-(morpholinomethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; 1-[4-(4-{5-[2-(4-Chloro-phenyl)-ethyl]-[1,3,4]thiadiazol-2-ylcarbamoyl}-2-oxo-pyrrolidin-1-yl)-3-fluoro-benzyl]-piperidinium; chloride; 4-[4-(4-{5-[2-(4-Chloro-phenyl)-ethyl]-[1,3,4]thiadiazol-2-ylcarbamoyl}-2-oxo-pyrrolidin-1-yl)-3-fluoro-benzyl]-morpholin-4-ium; chloride; 1-[4-(4-{5-[2-(4-Chloro-phenyl)-ethyl]-[1,3,4]thiadiazol-2-ylcarbamoyl}-2-oxo-pyrrolidin-1-yl)-3-fluoro-benzyl]-4-methyl-piperidinium; chloride; 1-{4-[(Ethyl-methyl-amino)-methyl]-phenyl}-5-oxo-pyrrolidine-3-carboxylic acid {5-[2-(4-chloro-phenyl)-ethyl]-[1,3,4]thiadiazol-2-yl}-amide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(2-oxa-7-azaspiro[3.4]octan-7-ylmethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; (3S)\u2014N-[5-[2-(4-chlorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]-1-[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide; 5-[2-(4-chlorophenyl)ethyl]-N-[(3R)-1-[4-(methanesulfonamidomethyl)phenyl]-5-oxo-pyrrolidin-3-yl]-1,3,4-thiadiazole-2-carboxamide; 1-(4-Morpholin-4-ylmethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid {5-[2-(4-fluoro-phenyl)-ethyl]-[1,3,4]thiadiazol-2-yl}-amide; hydrochloride.

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- Claim Count in Document: 47.0
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- Related Applications: ['15547776', '15554354', '10718337', '15533804', '10922425']

Analysis Scores:
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