PATENT CLAIM ANALYSIS

Application Number: 15928290
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["536", "023100"]

Abstract:
The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.

Claim (Index 1):
A compound having the formula: wherein R 1 , R 3 , R 5 , R 6 , and R 8  are each independently H, F, Cl, Br, I, CN, nitro (NO 2 ), azido, hydroxyl, amino, hydrazino, aryl, substituted aryl, aroxyl, substituted aroxyl, alkenyl, alkynyl, alkyl, alkoxy, alkylamino, dialkylamino, arylamino, diarylamino, alkyl(aryl)amino, alkanoylamino, alkylthio, alkylcarbonyl, aryl carbonyl, alkylthiocarbonyl, arylthiocarbonyl, alkyloxycarbonyl, aroxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, dialkylaminocarbonyl, diarylaminocarbonyl, alkyl(aryl)aminocarbonyl, arylcarboxamido, or Q, wherein the alkyl or alkoxy groups are saturated or unsaturated, linear or branched, unsubstituted or optionally substituted by F, Cl, Br, I, CN, OH, alkenyl, alkynyl, alkylcarbonyl, amide, thioamide, or Q, and the aryl group is optionally substituted by F, Cl, Br, I, CN, OH, alkenyl, alkynyl, alkylcarbonyl, amide, thioamide, or Q; Q is a carboxyl group (CO 2 ), a carbonate ester (COER 12 ), a sulfonate ester (SO 2 ER 12 ), a sulfoxide (SOR 12 ), a sulfone (SO 2 CR 12 R 13 R 14 ), a sulfonamide (SO 2 NR 12 R 13 ), a phosphate (PO 4 \u2212 ), a phosphate monoester (PO 3 \u2212 ER 12 ), a phosphate diester (PO 2 ER 12 ER 13 ), a phosphonate (PO 3 = ) a phosphonate monoester (PO 2 \u2212 ER 12 ) a phosphonate diester (POER 12 ER 13 ), a thiophosphate (PSO 3 = ), a thiophosphate monoester (PSO 2 \u2212 ER 12 ) a thiophosphate diester (PSOER 12 ER 13 ), a thiophosphonate (PSO 2 = ), a thiophosphonate monoester (PSO \u2212 ER 12 ), a thiophosphonate diester (PSER 12 ER 13 ), a phosphonamide (PONR 12 R 13 NR 15 R 16 ) or its thioanalogue (PSNR 12 R 13 NR 15 R 16 ), a phosphoramide (PONR 12 R 13 NR 14 NR 15 R 16 ) or its thioanalogue (PSNR 12 R 13 NR 14 NR 15 R 16 ), or a phosphoramidite (PO 2 R 15 NR 12 R 13 ) or its thioanalogue (POSR 15 NR 12 R 13 ), wherein E is independently O or S; R 10  is H, a saturated or unsaturated, linear or branched, unsubstituted or further substituted alkyl group, aryl group, alkylcarbonyl, aryl carbonyl, alkylthiocarbonyl, arylthiocarbonyl, alkoxycarbonyl, aroxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, dialkylaminocarbonyl, diarylaminocarbonyl, alkyl(aryl)aminocarbonyl, arylcarboxamido, or Q, the alkyl or alkoxy portions of which are, alkenyl, alkynyl, alkylcarbonyl, amide, thioamide, or Q, or the aryl portions of which are optionally substituted by F, Cl, Br, I, CN, OH, alkenyl, alkynyl, alkylcarbonyl, amide, thioamide, or Q.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 90.0
- Lexical Diversity: 1.5
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13270456', '15205438', '14672944', '15698069', '13565323']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7074772429552518
- 35 USC 102 Novelty (BERT): 0.5504131659428332
- Combined Prediction Score: 0.6917708352540101
- Mean Citation Score: 389.2076980000001
- Max Citation Score: 421.17596
- Similarity Product: 378.820794394896

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test