PATENT CLAIM ANALYSIS

Application Number: 15953108
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "279000"]

Abstract:
The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

Claim (Index 18):
The bifunctional compound according to any of  claims 2 - 16 , wherein the PTM is an estrogen receptor (ER) binding moiety represented by the chemical structure: wherein:\n each X PTM  is independently CH, N; \n  indicates the site of attachment of at least one of the linker (L), the CLM, a CLM\u2032, ULM, an ILM, a VLM, MLM, a ULM\u2032, a ILM\u2032, a VLM\u2032, a MLM\u2032, or a combination thereof; \n each R PTM1  is independently OH, halogen, alkoxy, methoxy, ethoxy, O(CO)R PTM , wherein the substitution can be a mono-, di- or tri-substitution and the R PTM  is alkyl or cycloalkyl group with 1 to 6 carbons or aryl groups; \n each R PTM2  is independently H, halogen, CN, CF 3 , liner or branched alkyl, alkoxy, methoxy, ethoxy, wherein the substitution can be mono- or di-substitution; \n each R PTM3  is independently H, halogen, wherein the substitution can be mono- or di-substitution; and \n R PTM4  is a H, alkyl, methyl, ethyl.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.675
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15881318', '14822309', '15730728', '16346483', '15148253']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7914790648076439
- 35 USC 102 Novelty (BERT): 0.5742465183968725
- Combined Prediction Score: 0.7697558101665667
- Mean Citation Score: 365.22769200000016
- Max Citation Score: 518.0048
- Similarity Product: 357.5762988283157

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test