PATENT CLAIM ANALYSIS

Application Number: 16037502
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-08
Patent Classification: ["424", "186100"]

Abstract:
Provided herein are a mutant envelope protein of Zika virus and a nucleic acid molecule including a nucleotide sequence encoding the mutant envelope protein. The mutant envelope protein, which preferably has a threonine substitution at 105 th  position, or an asparagine substitution at 248 th  position and a threonine substitution at 250 th  position in an amino acid sequence of SEQ ID NO: 1, includes an N-glycan masking a fusion loop region of the mutant envelope protein of Zika virus. Also provided herein is a vaccine composition, including the mutant envelope protein or a recombinant virus including the nucleic acid molecule. Also provided herein is a method of preventing Zika virus infection and reducing antibody-dependent enhancement of dengue virus infection, including administering to a subject in need thereof an effective amount of a vaccine composition including the mutant envelope protein of Zika virus.

Claim (Index 2):
The mutant envelope protein of Zika virus according to  claim 1 , which has a threonine substitution at 105 th  position, or an asparagine substitution at 248 th  position and a threonine substitution at 250 th  position in an amino acid sequence of SEQ ID NO: 1.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 95.0
- Lexical Diversity: 2.21739
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16009811', '15674585', '15674591', '15494945', '15549457']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7759849106199791
- 35 USC 102 Novelty (BERT): 0.5353049155291753
- Combined Prediction Score: 0.7519169111108988
- Mean Citation Score: 350.12971600000014
- Max Citation Score: 374.63702
- Similarity Product: 255.20772792746183

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test