PATENT CLAIM ANALYSIS

Application Number: 15996151
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "248000"]

Abstract:
The present disclosure relates to bifunctional compounds, which find utility as modulators of c-Met and/or p38 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Claim (Index 7):
The compound of  claim 1 , wherein the ULM is represented by the chemical structure: wherein:\n each R 5  and R 6  is independently \u2014OH, \u2014SH, or optionally substituted alkyl or R 5 , R 6 , and the carbon atom to which they are attached form a carbonyl; \n R 7  is H or optionally substituted alkyl; \n E is a bond, C\u2550O, or C\u2550S; \n G is a bond, optionally substituted alkyl, \u2014COOH or C=J; \n J is O or N\u2014R 8 ; \n R 8  is H, CN, optionally substituted alkyl or optionally substituted alkoxy; \n M is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclic or \n each R 9  and R 10  is independently H; optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted hydroxyalkyl, optionally substituted thioalkyl, a disulphide linked ULM, optionally substituted heteroaryl, or haloalkyl; or R 9 , R 10 , and the carbon atom to which they are attached form an optionally substituted cycloalkyl; R 11  is optionally substituted heterocyclic, optionally substituted alkoxy, optionally substituted heteroaryl, optionally substituted aryl, or R 12  is H or optionally substituted alkyl; R 13  is H, optionally substituted alkyl, optionally substituted alkylcarbonyl, optionally substituted (cycloalkyl)alkylcarbonyl, optionally substituted aralkylcarbonyl, optionally substituted arylcarbonyl, optionally substituted (heterocyclyl)carbonyl, or optionally substituted aralkyl; optionally substituted (oxoalkyl)carbamate, each R 14  is independently H, haloalkyl, optionally substituted cycloalkyl, optionally substituted alkyl or optionally substituted heterocycloalkyl; R 15  is H, optionally substituted heteroaryl, haloalkyl, optionally substituted aryl, optionally substituted alkoxy, or optionally substituted heterocyclyl; each R 16  is independently halo, optionally substituted alkyl, optionally substituted haloalkyl, CN, or optionally substituted haloalkoxy; each R 25  is independently H or optionally substituted alkyl; or both R 25  groups can be taken together to form an oxo or optionally substituted cycloalkyl group; R 23  is H or OH; Z 1 , Z 2 , Z 3 , and Z 4  are independently C or N; and o is 0, 1, 2, 3, or 4, or a pharmaceutically acceptable salt, stereoisomer, solvate or polymorph thereof.

Metadata:
- Claim Count in Document: 34.0
- Percentile: 94.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15881318', '14822309', '15341275', '15730728', '15847628']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8062059892866783
- 35 USC 102 Novelty (BERT): 0.6155902580700657
- Combined Prediction Score: 0.7871444161650171
- Mean Citation Score: 439.84440000000006
- Max Citation Score: 695.188
- Similarity Product: 471.2436333503723

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test