PATENT CLAIM ANALYSIS

Application Number: 16087308
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["548", "430000"]

Abstract:
Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.

Claim (Index 9):
The method of  claim 8 , wherein\n in Step 1, a reaction solvent is selected from the group consisting of N,N-dimethylformamide, N,N-dimethylacetamide, water, dichloromethane or chloroform, preferably water; the base is selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium hydrogencarbonate, sodium carbonate or potassium carbonate; a molar ratio of the piperic acid, base and N-bromosuccinimide (NBS) is 1:1.2-2:1.4-2.4; a reaction temperature is controlled to be 0 to 70\u00b0 C., preferably 30 to 45\u00b0 C.; in Step 2, R 3  is methyl, ethyl or isopropyl, more preferably ethyl; the acid is concentrated sulfuric acid; in Step 3, the cyanide ion donor is selected from metal cyanide, preferably cuprous cyanide (CuCN) or potassium ferrocyanide/copper iodide (K 4 Fe(CN) 6 /CuI), more preferably potassium ferrocyanide/cuprous iodide (K 4 Fe(CN) 6 /CuI); more preferably, a molar ratio of the compound shown by Formula III to cuprous iodide (CuI) is 1:1 to 1:2, preferably 1:1.1 to 1:1.5; a molar ratio of the compound shown by Formula III to potassium ferrocyanide (K 4 Fe(CN) 6 ) is 1:0.15 to 1:0.35, preferably 1:0.18 to 1:0.25, a reaction temperature is controlled to be 100 to 160\u00b0 C., preferably 120 to 140\u00b0 C.; the reaction solvent is selected from N,N-dimethylformamide or N,N-dimethylacetamide.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 97.0
- Lexical Diversity: 1.47692
- Patent Class: 548.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15514326', '15763676', '16083485', '13994085', '16345744']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7533958656055375
- 35 USC 102 Novelty (BERT): 0.5081571234925907
- Combined Prediction Score: 0.7288719913942429
- Mean Citation Score: 262.935172
- Max Citation Score: 271.25452
- Similarity Product: 201.9955328519536

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test