PATENT CLAIM ANALYSIS

Application Number: 16093565
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-03
Patent Classification: ["514", "259300"]

Abstract:
The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R 1 , R 2 , R 3  and R 4  are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Claim (Index 9):
A compound of formula (II): in which: o is 0 or 1, R is selected from the group consisting of hydrogen, fluorine, chlorine, methyl, n is 0 or 1, X is selected from the group consisting of CH 2  and O, Y is CH 2 , R 1  is hydrogen, R 2  is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, isobutyl, sec-butyl, cyclopropyl, methoxymethyl, difluoromethyl, trifluoromethyl, 4-fluorobenzyl, methoxy, methylamino, dimethylamino, cyclopropylamino, \u2014N(CH 3 )(cyclopropyl), \u2014N(CH 3 )(CH 2 \u2014N(CH 3 ) 2 ), \u2014N(CH 3 )(CH 2 \u2014CHF 2 ), \u2014N(CH 3 )((CH 2 ) 2 O(CH 2 ) 2 )O(CH 2 ) 2 )OCH 3 ), \u2014N(CH 3 )((CH 2 ) 2 \u2014S\u2014CH 3 ), \u2014N(CH 3 )((CH 2 ) 2 \u2014S(O)\u2014CH 3 ), \u2014N(CH 3 )((CH 2 ) 2 \u2014SO 2 \u2014CH 3 ), N(CH 3 )(1-methyl-piperidin-4-yl), \u2014N(CH 3 )((CH 2 ) 2 -(oxopyrrolidin-1-yl)), morpholino, CH 2 \u2014N(CH 3 ) 2 , R 3  is selected from the group consisting of hydrogen and methyl, R 4  is selected from the group consisting of hydrogen, chlorine, methyl, cyclopropyl, difluoromethyl, trifluoromethyl, \u2014S-methyl, \u2014S-ethyl, \u2014S-isopropyl, \u2014S(O) 2 -methyl, \u2014S(O) 2 -ethyl, \u2014S(O) 2 -isopropyl, and Q is a substituted phenyl ring of the formula (Q1) in which: Z 1 , Z 2 , Z 3 , Z 4 , and Z 5  are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, cyano, methyl, propyl, difluoromethyl, trifluoromethyl, hydroxy, methoxy, ethoxy, isopropoxy, \u2014O-cyclopropyl, \u2014OCH 2 -cyclopropyl, \u2014OCH 2 CN, trifluoromethoxy, difluoromethoxy, trifluoroethoxy, methylamino, dimethylamino, methylethylamino, diethylamino, acetylamino, methylsulfonamide, trifluoroacetylamino, \u2014SO 2 Me, \u2014SO 2 -cyclopropyl, \u2014CH 2 \u2014O-methyl, \u2014CH 2 \u2014O-ethyl, \u2014CH 2 \u2014O\u2014CH 2 -cyclopropyl, \u2014CH 2 \u2014O-isopropyl, \u2014CH 2 \u2014N(CH 3 ) 2 , \u2014CH 2 \u2014N(CH 2 CH 3 ) 2 , \u2014CH 2 \u2014N(CH 3 )(CH 2 CH 3 ), \u2014CH 2 \u2014SCH 3 , \u2014CH 2 \u2014S(O)CH 3 , \u2014CH 2 \u2014SO 2 \u2014CH 3 , \u2014C(O)NH\u2014 cyclopropyl, and wherein at least two of Z 1 , Z 2 , Z 3 , Z 4 , and Z 5  are hydrogen, or Q is a pyridine ring of the formula (Q2) in which: Z 6  is hydrogen, Z 7 , Z 8  are independently selected from the group consisting of hydrogen, fluorine, chlorine, and Z 9  is selected from the group consisting of hydrogen and chlorine, or Q is a pyrimidine ring of the formula (Q3) in which: Z 1  and Z 12  are hydrogen, and Z 1  is selected from the group consisting of hydrogen and chlorine, or Q is a pyridine ring of the formula (Q4) in which: Z 13 , Z 15 , and Z 16  are hydrogen, and Z 14  is selected from the group consisting of hydrogen and chlorine, NH 2 , \u2014NH\u2014CO\u2014C 1 -C 4 -alkyl, \u2014NH(C 1 -C 4 -alkyl), \u2014N(C 1 -C 4 -alkyl) 2 , morpholino, or Q is a pyridine ring of the formula (Q5) in which: Z 17  is selected from the group consisting of fluorine, chlorine, methoxy, trifluoromethyl, Z 18  and Z 20  are selected from the group consisting of hydrogen and chlorine, Z 19  is hydrogen, or Q a pyrazole ring of the formula (Q6) in which: Z 21  and Z 23  are hydrogen, and Z 22  is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, methoxyethyl, \u2014CH 2 -cyclopropyl, \u2014CH 2 CF 3 , \u2014CH 2 CHF 2 , \u2014CH 2 -morpholino, \u2014CH 2 \u2014CH 2 \u2014N(CH 3 ) 2 , and/or \u2014CH 2 \u2014CH 2 -morpholino, or Q is a pyrazole ring of the formula (Q7) in which: Z 24  and Z 26  are hydrogen, and Z 25  is selected from the group consisting of hydrogen and chlorine, or Q is selected from the group consisting of or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of any of the foregoing.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 97.0
- Lexical Diversity: 1.67213
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15022583', '14914069', '15300057', '14767621', '14772471']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7953894262048244
- 35 USC 102 Novelty (BERT): 0.5211296262275457
- Combined Prediction Score: 0.7679634462070966
- Mean Citation Score: 295.60647
- Max Citation Score: 308.264
- Similarity Product: 228.79666960716247

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test