PATENT CLAIM ANALYSIS

Application Number: 16246999
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["549", "214000"]

Abstract:
The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

Claim (Index 13):
The method of any one of  claims 9  to  12 , wherein P 4  is a hydroxyl protecting group.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 99.0
- Lexical Diversity: 1.88679
- Patent Class: 549.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15033970', '15707412', '15571921', '11874218', '14069057']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7552099090218392
- 35 USC 102 Novelty (BERT): 0.5814328028724507
- Combined Prediction Score: 0.7378321984069003
- Mean Citation Score: 425.015932
- Max Citation Score: 529.3929400000002
- Similarity Product: 360.3020831280256

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test