PATENT CLAIM ANALYSIS

Application Number: 15882475
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-01
Patent Classification: ["514", "152000"]

Abstract:
The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.

Claim (Index 1):
A compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein:\n X is selected from hydrogen, \u2014(C 1 -C 7 )alkyl, carbocyclyl, aryl and heteroaryl; \n Y is selected from hydrogen, \u2014(C 1 -C 7 )alkyl, carbocyclyl, \u2014(C 1 -C 4 )alkylene-N(R A )(R B ), \u2014(C 1 -C 4 )alkylene-N(R F )\u2014C(O)\u2014[C(R D )(R E )] 0-4 \u2014N(R A )(R B ), \u2014CH\u2550N\u2014OR A , \u2014N(R A )(R B ), \u2014N(R F )\u2014C(O)\u2014[C(R D )(R E )] 1-4 \u2014N(R A )(R B ), \u2014N(R F )\u2014C(O)\u2014N(R A )(R B ), \u2014N(R F )\u2014C(O)\u2014(C 1 -C 6 )alkyl, \u2014N(R F )\u2014C(O)-heterocyclyl, \u2014N(R F )\u2014C(O)-heteroaryl, \u2014N(R F )\u2014C(O)-carbocyclyl, \u2014N(R F )\u2014C(O)-aryl, \u2014N(R F )\u2014S(O) m \u2014(C 1 -C 4 )alkylene-N(R A ) (R B ), \u2014N(R F )\u2014S(O) m \u2014(C 1 -C 4 )alkylene-carbocyclyl, and \u2014N(R F )\u2014S(O) m \u2014(C 1 -C 4 )alkylene-aryl wherein: \n at least one of X and Y is not hydrogen; \n each R A  and R B  are independently selected from hydrogen, (C 1 -C 7 )alkyl, \u2014O\u2014(C 1 -C 7 )alkyl, \u2014(C 0 -C 6 )alkylene-carbocyclyl, \u2014(C 0 -C 6 )alkylene-aryl, \u2014(C 0 -C 6 )alkylene-heterocyclyl, \u2014(C 0 -C 6 )alkylene-heteroaryl, \u2014(C 1 -C 6 )alkylene-O-carbocyclyl, \u2014(C 1 -C 6 )alkylene-O-aryl, \u2014(C 1 -C 6 )alkylene-O-heterocyclyl, \u2014(C 1 -C 6 )alkylene-O-heteroaryl, \u2014S(O) m \u2014(C 1 -C 6 )alkyl, \u2014(C 0 -C 4 )alkylene-S(O) m -carbocyclyl, \u2014(C 0 -C 4 )alkylene-S(O) m -aryl, \u2014(C 0 -C 4 )alkylene-S(O) m -heterocyclyl and \u2014(C 0 -C 4 )alkylene-S(O) m -heteroaryl; or \n R A  and R B  taken together with the nitrogen atom to which they are bound form a heterocyclyl or heteroaryl, wherein the heterocycle or heteroaryl optionally comprises 1 to 4 additional heteroatoms independently selected from N, S and O; \n each R D  and each R E  is independently selected from hydrogen, (C 1 -C 6 )alkyl, carbocyclyl, aryl, heterocyclyl, heteroaryl, or a naturally occurring amino acid side chain moiety, or \n R D  and R E  taken together with the carbon atom to which they are bound form a 3-7 membered carbocyclyl, or a 4-7 membered heterocyclyl, wherein the heterocyclyl formed by R D  and R E  optionally comprises one to two additional heteroatoms independently selected from N, S and O; \n R F  is selected from hydrogen, (C 1 -C 7 )alkyl, carbocyclyl, aryl and heteroaryl; and \n m is 1 or 2, wherein: \n each carbocyclyl, aryl, heterocyclyl or heteroaryl is optionally and independently substituted with one or more substituents independently selected from halo, \u2014(C 1 -C 4 )alkyl, \u2014OH, \u2550O, \u2014O\u2014(C 1 -C 4 )alkyl, \u2014(C 1 -C 4 )alkyl-O\u2014(C 1 -C 4 )alkyl, halo-substituted \u2014(C 1 -C 4 )alkyl, halo-substituted \u2014O\u2014(C 1 -C 4 )alkyl, \u2014C(O)\u2014(C 1 -C 4 )alkyl, \u2014C(O)-(fluoro-substituted-(C 1 -C 4 )alkyl), \u2014S(O) m \u2014(C 1 -C 4 )alkyl, \u2014N(R G )(R G ), and CN; \n each alkyl in the group represented by R A , R B , R D  and R E  is optionally and independently substituted with one or more substituents independently selected from halo, \u2014(C 1 -C 4 )alkyl, \u2014OH, \u2014O\u2014(C 1 -C 7 )alkyl, \u2014(C 1 -C 4 )alkyl-O\u2014(C 1 -C 4 )alkyl, fluoro-substituted-(C 1 -C 4 )alkyl, \u2014S(O) m \u2014(C 1 -C 4 )alkyl, and \u2014N(R G )(R G ), wherein \n each R G  is hydrogen or (C 1 -C 4 )alkyl, wherein each alkyl in the group represented by R G  is optionally and independently substituted with one or more substituents independently selected from \u2014(C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, halo, \u2014OH, \u2014O\u2014(C 1 -C 4 )alkyl, and (C 1 -C 4 )alkyl-O\u2014(C 1 -C 4 )alkyl.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.44737
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15323081', '13391407', '15296601', '15130358', '14620700']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8008789505011734
- 35 USC 102 Novelty (BERT): 0.5316162236366241
- Combined Prediction Score: 0.7739526778147184
- Mean Citation Score: 353.88025600000014
- Max Citation Score: 361.04553
- Similarity Product: 302.9274598850208

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test