PATENT CLAIM ANALYSIS

Application Number: 15994999
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "093200"]

Abstract:
Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Claim (Index 77):
The method of  claim 76 , wherein the mutated form of HSV-TK comprises mutations at amino acid residue 32 and at least one of amino acid residues 25, 26, or 168, wherein the amino acid residues correspond to positions 32, 25, 26, and 168 of SEQ ID NO: 2.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 1.275
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14214448', '14214522', '15892295', '10457604', '12319640']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7277279905305261
- 35 USC 102 Novelty (BERT): 0.6416003793791681
- Combined Prediction Score: 0.7191152294153903
- Mean Citation Score: 416.24180000000007
- Max Citation Score: 628.63104
- Similarity Product: 546.9561442144775

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test