PATENT CLAIM ANALYSIS

Application Number: 15978146
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-01
Patent Classification: ["514", "714000"]

Abstract:
The present disclosure relates to methods of treatment of acne in a patient in need thereof, comprising the concomitant once daily topical administration of from about 20 w/w to about 10% w/w of solid particulate benzoyl peroxide (BPO) and from about 0.01% w/w to about 0.1% w/w of solid particulate all trans retinoic acid (ATRA) for a period of up to 3 months, wherein the side-effects of the two actives are medically acceptable and wherein the therapeutic effect of BPO and ATRA is superior to the effect of each active administered alone. The concomitant administration may be carried out by once daily administration to a patient in need thereof of a single composition or of a first composition comprising BPO and a second composition comprising ATRA from a dual chamber dispenser or from two separate dispensers, mixed before applying on the skin of a patient in need thereof for up to 2 weeks, up to 1 month, preferably up to 2 months and more preferably up to 3 months.

Claim (Index 6):
The method of  claim 1 , wherein said stable composition comprising an initial concentration of 3% w/w BPO and an initial concentration of 0.05% w/w ATRA and wherein the composition maintains the amount of BPO at a level of at least about 2.7% by weight based on the total weight of the composition, as measured after storage of the composition at a storage condition selected from the group consisting of 40\u00b0 C. for two months, 30\u00b0 C. for three months, 25\u00b0 C. for six months and 5\u00b0 C. for two years and maintains the amount of ATRA at a level of at least about 0.045% by weight based on the total weight of the composition, as measured after storage of the composition at a storage condition selected from the group consisting of 40\u00b0 C. for two months, 30\u00b0 C. for three months, 25\u00b0 C. for six months and 5\u00b0 C. for two years; (ii) maintain the microbial count of the composition at a level that meets the criteria of USP 51, as measured by Antimicrobial Effectiveness Testing (AET) after storage of the composition at a storage condition of 40\u00b0 C. for one month; and maintains the bulk viscosity of said composition at about one million cps or less and within a range of about 70% to about 130% of the initial bulk viscosity, as measured after storage of the composition at 25\u00b0 C. for three months.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 2.03333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13495701', '13686533', '12818924', '13243189', '09983229']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7616837995635252
- 35 USC 102 Novelty (BERT): 0.5223535895350183
- Combined Prediction Score: 0.7377507785606745
- Mean Citation Score: 226.669252
- Max Citation Score: 254.4074
- Similarity Product: 122.49679152470829

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test