PATENT CLAIM ANALYSIS

Application Number: 16038389
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["435", "006100"]

Abstract:
Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.

Claim (Index 44):
The method of  claim 29 , which comprises the detection of multiple different targets, which method comprises repeating steps (a) through (c) as many times as the number of different targets that are to be detected, wherein, for each of the repeated steps (a) through (c) which are conducted to detect a different target, another detection probe is substituted for the first or any previous detection probes used in the detection of the previously detected target or targets; another enzyme conjugate is substituted for said first or previous enzyme conjugates used in the detection of the previously detected target or targets; another binding complex is substituted for said first or previous binding complexes used in the detection of the previously detected target or targets; another signaling conjugate is substituted for said first signaling conjugate or previous signaling conjugates used in the detection of the previously detected target or targets; another chromogenic moiety is substituted for said first chromogenic moiety or any previous chromogenic moieties used in the detection of the previously detected target or targets; and another signaling complex is substituted for said first signaling complex or any previous signaling complexes used in the detection of the previously detected target or targets; wherein each time prior to repeating steps (a) through (c) for the detection of a specific target, inactivating the enzyme of the first enzyme conjugate or the enzyme of the enzyme conjugate used to detect the target which was detected in the immediately prior steps (a) through (c).

Metadata:
- Claim Count in Document: 56.0
- Percentile: 95.0
- Lexical Diversity: 1.96296
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13849160', '14769892', '14691826', '15246430', '15603079']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6368437124993517
- 35 USC 102 Novelty (BERT): 0.6013143547975452
- Combined Prediction Score: 0.633290776729171
- Mean Citation Score: 419.83629200000007
- Max Citation Score: 733.6904
- Similarity Product: 423.24141865644447

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test