PATENT CLAIM ANALYSIS

Application Number: 15949769
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["530", "317000"]

Abstract:
Provided is a cyclic peptide, which is represented by Formula (I) or Formula (I′) and has excellent antibody binding properties and improved chemical resistance, an affinity chromatography support, a labeled antibody, an antibody drug conjugate, and a pharmaceutical preparation. R N -X g -[X i -X a -X m -X 2 -X 3 -X n -X b -X j ] k -X h -R C   (I) In Formula (I), X a  and X b  each independently represent an amino acid residue derived from an amino acid, other than L-cysteine and D-cysteine, having a thiol group on a side chain and are bonded to each other through a disulfide bond, or, one of X a  and X b  represents an amino acid residue derived from an amino acid, other than L-cysteine and D-cysteine, having a thiol group on a side chain and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and X a  and X b  are bonded to each other through a thioether bond. R N -X g -[X i -X a -X m -X 1 -X 2 -X 3 -X n -X b -X j ] k -X h -R C   (I′) In Formula (I′), one of X a  and X b  represents an amino acid residue derived from L-cysteine or D-cysteine and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and X a  and X b  are bonded to each other through a thioether bond, or, one of X a  and X b  represents an amino acid residue derived from L-penicillamine or D-penicillamine and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and X a  and X b  are bonded to each other through a thioether bond.

Claim (Index 4):
The cyclic peptide according to  claim 1  that is represented by Formula (IC),\n R N -X v1 -X 6 t -X v2 -[X p2 -X 4 r -X p1 -X a -X m -X 1 -X 2 -X 3 -X n -X b -X q1 -X 5 s -X q2 ] k -X w2 -X 7 u -X w1 -R C \u2003\u2003 (IC): \n \n in Formula (IC), \n R N , R C , X 1 , X 2 , X 3 , X a , X b , X m , X n , X, m, n, and k have the same definitions as those in Formula (I); \n X p1 , X p2 , X q1 , X q2 , X 4 r , X 5 s , X 6 t , X 7 u , X v1 , X v2 , X w1 , and X w2  each represent p1 consecutive X's, p2 consecutive X's, q1 consecutive X's, q2 consecutive X's, r consecutive X 4 's, s consecutive X 5 's, t consecutive X 6 's, u consecutive X 7 's, v1 consecutive X's, v2 consecutive X's, w1 consecutive X's, and w2 consecutive X's\u2032; \n X 4  and X 5  each independently represent an amino acid residue derived from an amino acid having a carboxy group on a side chain or an amino acid residue derived from an amino acid having a hydroxy group on a side chain, and in a case where there is a plurality of X 4 's or X 5 's, the plurality of X 4 's or X 5 's may be the same as or different from each other; \n X 6  and X 7  each independently represent an amino acid residue derived from an amino acid having an immobilizing functional group on a side chain, and in a case where there is a plurality of X 6  or X 7 , the plurality of X 6 's or X 7 's may be the same as or different from each other; \n p1, p2, q1, and q2 each independently represent an integer equal to or greater than 0; \n r and s each represent an integer satisfying 0\u2264r\u22645, 0\u2264s\u22645, and 1\u2264Max (r,s)\u22645, \n where Max (r,s) represents a larger one between two numbers represented by r and s in a case where r\u2260s and represents r or s in a case where r=s; \n t and u each represent an integer satisfying 0\u2264t\u22645, 0\u2264u\u22645, and 1\u2264Max (t,u)\u22645, where Max (t,u) represents a larger one between two numbers represented by t and u in a case where t\u2260u and represents t or u in a case where t=u; \n v1, v2, w1, and w2 each independently represent an integer equal to or greater than 0; and \n in a case where k\u22652, X 1 , X 2 , X 3 , X a , X b , X 4 r , X 5 s , X m , X n , X p2 , X p1 , X q1 , and X q2  in a repeating unit [X p2 -X 4 r -X p1 -X a -X m -X 1 -X 2 -X 3 -X n -X b -X q1 -X 5 s -X q2 ] each may be the same or different between the repeating units.

Metadata:
- Claim Count in Document: 31.0
- Percentile: 91.0
- Lexical Diversity: 4.04598
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14240083', '13258663', '11721910', '13990123', '14358816']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7155773379240046
- 35 USC 102 Novelty (BERT): 0.5170955836606644
- Combined Prediction Score: 0.6957291624976705
- Mean Citation Score: 253.962472
- Max Citation Score: 275.18484
- Similarity Product: 159.0786058581305

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test