PATENT CLAIM ANALYSIS

Application Number: 16009093
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "210210"]

Abstract:
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Claim (Index 59):
A compound, or a pharmaceutically acceptable salt thereof, having the structure of Formula (I): wherein,\n Ring A is an optionally substituted bicyclic heteroaryl ring selected from optionally substituted quinolyl, optionally substituted indolyl, optionally substituted indazolyl, optionally substituted benzimidazolyl, optionally substituted isoquinolyl, optionally substituted cinnolinyl, optionally substituted phthalazinyl, optionally substituted quinazolinyl, optionally substituted naphthyridinyl, or optionally substituted benzoisoxazolyl; \n Ring B is an optionally substituted monocyclic heteroaryl ring selected from optionally substituted imidazolyl, optionally substituted pyrazolyl, optionally substituted pyridinyl, optionally substituted pyridazinyl, optionally substituted pyrimidinyl, or optionally substituted pyrazinyl; or optionally substituted bicyclic heteroaryl ring selected from optionally substituted quinolinyl, optionally substituted isoquinolinyl, optionally substituted quinazolinyl, optionally substituted indolyl, optionally substituted indazolyl, optionally substituted 1H-pyrrolo[2,3-b]pyridinyl, optionally substituted benzoxazolyl, optionally substituted benzoisoxazolyl, or optionally substituted benzimidazolyl; \n R 12  is hydrogen; \n R 13  is selected from cyano, halo, hydroxy, azido, amino, nitro, \u2014CO 2 H, \u2014S(O)\u2014R 20 , \u2014S\u2014R 20 , \u2014S(O) 2 \u2014R 20 , optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted (heterocyclyl)-O\u2014, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkylamino, optionally substituted dialkylamino, \u2014CO\u2014R 20 , \u2014CO 2 \u2014R 20 , \u2014CO(NR 21 ) 2 , \u2014SO 2 (NR 21 ) 2 , \u2014C(\u2550NR 22 )\u2014(NR 21 ) 2 , or optionally substituted alkynyl; \n R 14  is selected from hydrogen, cyano, halo, hydroxy, azido, amino, nitro, \u2014CO 2 H, \u2014S(O)\u2014R 20 , \u2014S\u2014R 20 , \u2014S(O) 2 \u2014R 20 , optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted (heterocyclyl)-O\u2014, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkylamino, optionally substituted dialkylamino, \u2014CO\u2014R 20 , \u2014CO 2 \u2014R 20 , \u2014CO(NR 21 ) 2 , \u2014SO 2 (NR 21 ) 2 , \u2014C(\u2550NR 22 )\u2014(NR 21 ) 2 , or optionally substituted alkynyl; \n each R 1  or R 2  is independently selected from hydrogen, halo, hydroxy, amino, \u2014CO 2 H, \u2014S(O)\u2014R 20 , \u2014S\u2014R 20 , \u2014S(O) 2 \u2014R 20 , optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted (heterocyclyl)-O\u2014, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkylamino, optionally substituted dialkylamino, \u2014CO\u2014R 20 , \u2014CO 2 \u2014R 20 , \u2014CO(NR 21 ) 2 , \u2014SO 2 (NR 21 ) 2 , \u2014C(\u2550NR 22 )\u2014(NR 21 ) 2 , or optionally substituted alkynyl; or optionally, R 1  and R 2  are optionally substituted C1-C5 alkyl and join to form a ring; or optionally, R 1  and R 2  together form an oxo; \n each R 3  or R 4  is independently selected from hydrogen, \u2014CO 2 H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, \u2014CO\u2014R 20 , \u2014CO 2 \u2014R 20 , \u2014CO(NR 21 ) 2 , \u2014SO 2 (NR 21 ) 2 , \u2014C(\u2550NR 22 )\u2014(NR 21 ) 2 , or optionally substituted alkynyl; or optionally, R 3  and R 4  are optionally substituted C1-C5 alkyl and join to form a ring; \n each R 20  is selected from optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl; \n each R 21  is selected from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl; and \n each R 22  is selected from hydrogen, \u2014CN, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl.

Metadata:
- Claim Count in Document: 126.0
- Percentile: 94.0
- Lexical Diversity: 1.52941
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15042102', '14800631', '15470736', '15807331', '11478547']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8129780222887891
- 35 USC 102 Novelty (BERT): 0.5924189479247188
- Combined Prediction Score: 0.7909221148523821
- Mean Citation Score: 416.284212
- Max Citation Score: 485.7676
- Similarity Product: 481.46599030330185

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test