PATENT CLAIM ANALYSIS

Application Number: 15771906
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["435", "071100"]

Abstract:
We discovered that recombinant antibody light chains having a murine secretory leader sequence and an SYE motif at the N-terminus are truncated during post-translational processing. This disclosure provides two protein engineering solutions: to alter the SYE amino acid sequence of the Lc N-terminus to other alternatives; or to change the secretory leader peptide sequence. We have shown that both of these solutions are effective for preventing N-terminal light chain truncation.

Claim (Index 7):
The method according to any one of  claims 1 - 3 , wherein the second nascent N-terminal sequence is SEQ ID NO: 9.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.33929
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13934570', '12824058', '12163719', '11777777', '13800233']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.62496464459167
- 35 USC 102 Novelty (BERT): 0.524507057887748
- Combined Prediction Score: 0.6149188859212777
- Mean Citation Score: 274.353972
- Max Citation Score: 290.66144
- Similarity Product: 165.8725634212494

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test