PATENT CLAIM ANALYSIS

Application Number: 16069932
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["530", "399000"]

Abstract:
The invention relates to compounds derived from the EGF(A) domain of LDL-R, in particular compounds comprising a peptide analogue of the wild-type EGF(A) (LDL-R(293-332)) sequence and at least one substituent comprising at least one fatty acid group. The invention also relates to a pharmaceutical composition thereof and use a medicament. The novel EGF(A) compounds of the invention are useful as treatment e.g. in the field of cholesterol lowering, dyslipidaemia and cardiovascular disease.

Claim (Index 3):
The EGF(A) derivative according to  claim 1 , wherein said substituent has Formula I:\n Z 1 \u2014Z 2 \u2014Z 3 \u2014Z 4 \u2014Z 5 \u2014Z 6 \u2014Z 7 \u2014Z 8 \u2014Z 9 \u2014Z 10 \u2014\u2003\u2003[I] wherein Z 1  is selected from:\n Chem. 1: HOOC\u2014(CH 2 ) n \u2014CO\u2014*, \n Chem. 2: tetrazolyl-(CH 2 ) n \u2014CO\u2014*, \n Chem. 3: HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) m \u2014CO\u2014*, \n Chem. 4: HOS(O) 2 \u2014(CH 2 ) n \u2014CO\u2014*, \n Chem. 5: MeS(O) 2 NH(CO)N\u2014(CH 2 ) n \u2014CO\u2014* and \n Chem. 6: 3-HO-Isoxazole-(CH 2 ) n \u2014CO\u2014* \n wherein \n n is an integer in the range of 8-20, \n m is an integer in the range of 8-11, \n the \u2014COOH group in Chem. 3 can be attached to position 2, 3 or 4 on the phenyl ring, the symbol * indicates the attachment point to the nitrogen in Z 2  or, if Z 2  is a bond, to the nitrogen on the neighbouring Z element; \n Z 2  is selected from\n Chem. 7: *\u2014NH\u2014SO 2 \u2014(CH 2 ) 3 \u2014CO\u2014*, \n Chem. 8: *\u2014NH\u2014CH 2 \u2014(C 6 H 10 )\u2014CO\u2014* and \n a bond; \n Z 3  is selected from:\n \u03b3Glu, Glu and a bond; \n Z 4 , Z 5 , Z 6 , Z 7 , Z 8 , Z 9  are selected, independently of each other, from:\n Glu, \u03b3Glu, Gly, Ser, Ala, Thr, Ado, Aeep, Aeeep, TtdSuc and a bond; and \n Z 10  is selected from:\n Chem. 14: *\u2014NH\u2014CH 2 \u2014(C 6 H 4 )\u2014CH 2 \u2014* and a bond.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 95.0
- Lexical Diversity: 1.76923
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15301960', '15966642', '15404808', '14399087', '15315985']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.719282349356045
- 35 USC 102 Novelty (BERT): 0.521894772273339
- Combined Prediction Score: 0.6995435916477744
- Mean Citation Score: 307.498832
- Max Citation Score: 329.66962
- Similarity Product: 232.68897144233463

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test