PATENT CLAIM ANALYSIS

Application Number: 16354416
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "255050"]

Abstract:
PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.

Claim (Index 1):
A method for treating a cancer selected from melanoma, uveal melanoma, lymphoma, diffused large B-cell lymphoma, ibrutinib resistant cancers, papillary cancer, thyroid cancer, ovarian cancer, colon cancer, pancreatic cancer, non-small cell lung cancer, hematological cancers, chronic myelogenous leukemia, acute lymphoblastic leukemia and acute myeloid leukemia in a human subject in recognized need of such treatment, comprising administering to the subject a therapeutically effective amount of a compound formula II: or a pharmaceutically acceptable salt thereof, wherein: X is N or CR; R, R 2 , R 3  and R 4  are each independently H,  2 H, halo, hydroxy (\u2014OH), C 1-3  alkoxy, C 1-3  haloalkyl or C 1-3  alkyl, said C 1-3  alkyl optionally substituted with hydroxyl, halo, C 1-3  alkoxy or C 1-3  haloalkoxy; R 5  is independently H,  2 H, CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 OH, or C 1-3  alkyl, said C 1-3  alkyl optionally substituted with F, OH, C 1-3  alkoxy or C 1-3  haloalkoxy; R 5a  and R 5b  are each independently H,  2 H, C 1-3  alkyl, said C 1-3  alkyl optionally substituted with F, OH or C 1-3  alkoxy, or R 5a  and R 5b  are joined together forming a methylene or ethylene bridging group; R 5c  and R 5d  are each independently H,  2 H, F, \u2014OH, C 1-3  alkoxy, C 1-3  alkyl, said C 1-3  alkyl optionally substituted with F, OH or C 1-3  alkoxy, or R 5c  and R 5d  are joined together forming a methylene, ethylene or \u2014CH 2 \u2014O\u2014 bridging group; R 6 , R 7  and R 8  are each independently selected from H,  2 H, halo, C 1-3  alkyl, C 1-3  haloalkyl, C 1-3  alkoxy, C 1-3  haloalkoxy, C 3-7  cycloalkyl and 4-7 membered heterocyclyl having 1 to 3 heteroatoms selected from N, O and S, said C 1-3  alkyl optionally substituted with F, OH, C 1-3  alkoxy or C 1-3  haloalkoxy; or wherein R 6  and R 8  optionally forms a partially saturated carbobicyclic ring or heterobicyclic ring with the heteroaryl ring, said carbobicyclic ring or heterobicyclic ring optionally substituted with 1 to 3 groups selected from:  2 H, halo, C 1-3  haloalkyl, C 1-3  alkoxy, C 1-3  haloalkoxy, C 3-7  cycloalkyl and 4-7 membered heterocyclyl having 1 to 3 heteroatoms selected from N, O and S.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 99.0
- Lexical Diversity: 1.4
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15237880', '14818778', '14559889', '10046681', '12502967']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7726942800484146
- 35 USC 102 Novelty (BERT): 0.5856026380414847
- Combined Prediction Score: 0.7539851158477215
- Mean Citation Score: 383.300708
- Max Citation Score: 535.83545
- Similarity Product: 384.80516075757447

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test