PATENT CLAIM ANALYSIS

Application Number: 16302158
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["514", "210180"]

Abstract:
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.

Claim (Index 9):
The compound according to  claim 1 , wherein the compound is represented by Formula (IIIa) or (IIIb): wherein:\n R 1  is phenyl, pyridinyl, pyrrolidinonyl, or pyridinonyl; wherein the phenyl, pyridinyl, or pyridinonyl is each independently substituted with 0 or 1 R 6 ; \n R 2  is, independently at each occurrence, selected from: halogen, OH, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, CN, NH 2 , NH(C 1-4  alkyl), NO 2 , CO 2 H, CO 2 (C 1-4  alkyl), CONH 2 , and CONH(C 1-4  alkyl); \n R 3  is \u2014(CH 2 ) Y \u2014CONH(C 3-6  carbocyclyl substituted with 0, 1, or 2 R 7 ), \u2014(CH 2 ) Y \u2014CONH(4- to 6-membered heterocyclyl substituted with 0, 1, or 2 R 7 ), or \u2014(CH 2 ) Y \u2014CONR e R 4 ; \n R e  and R 4 , taken together with the atoms to which they are attached, form a 5- or 6-membered azacyclyl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a , O, and S(O) Z , wherein the azacyclyl is substituted with 0, 1, or 2 R 5 ; \n R 6  is, independently at each occurrence, selected from: OH, halogen, C 1-6  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, NH 2 , NHR g , OPh, OBn, Ph, \u2014CONH 2 ; \u2014CONHR i ; and \u2014CONR h R i ; or alternatively, two R 6 , taken together with the atoms to which they are attached, form a 5- or 6-membered heterocyclyl; wherein the heterocyclyl comprises one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a , O, and S(O) Z , and is substituted with 0, 1, 2, or 3 R 8 ; \n R 7 , R 8 , and R 9  are, independently at each occurrence, selected from: OH, halogen, C 1-6  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, NH 2 , NH(C 1-4  alkyl), OPh, OBn, Ph, and a 5- or 6-membered heteroaryl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a  and O; \n R a  is, independently at each occurrence, hydrogen, C 1-4  alkyl, or C 3-6  carbocyclyl; \n R g  is C 1-4  alkyl, CO 2 H, CO 2 R m , CONH 2 ; CONHR p ; \n R i  is C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy; or alternatively, R h  and R i , taken together with the atoms to which they are attached, form a 5- or 6-membered azacyclyl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a , O, and S(O) Z ), wherein the azacyclyl is substituted with 0, 1, or 2 R 9 ; \n R m  and R p  are independently C 1-4  alkyl, C 3-6  carbocyclyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, OPh, OBn, Ph, and a 5- or 6-membered heteroaryl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a  and O; \n X is 0, 1, or 2; \n Y is 1 or 2; \n Z is, independently at each occurrence, 0, 1, or 2; and \n Q is, independently at each occurrence, 0 or 1.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 98.0
- Lexical Diversity: 1.15152
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13936311', '13944921', '14427105', '14346745', '14390152']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7446911737776837
- 35 USC 102 Novelty (BERT): 0.5192742331592483
- Combined Prediction Score: 0.7221494797158401
- Mean Citation Score: 302.8511640000001
- Max Citation Score: 311.87286
- Similarity Product: 255.87897176163915

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test