PATENT CLAIM ANALYSIS

Application Number: 16209807
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["800", "008000"]

Abstract:
A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.

Claim (Index 21):
A transgenic chicken that comprises a genome comprising a recombinant immunoglobulin heavy chain (IgH) locus comprising:\n (a) a functional IgH gene comprising a nucleic acid encoding a heavy chain variable region comprising:\n (i) heavy chain complementarity determining (CDR) regions; and \n (ii) a heavy chain framework; and, \n (b) a plurality of pseudogenes that encode heavy chain variable regions each comprising:\n (i) heavy chain CDR regions; and \n (ii) a heavy chain framework region that is identical in amino acid sequence to the heavy chain framework of a) (ii); \n wherein said nucleic acid of (a) and pseudogene of (b), are exogenous to the genome of said transgenic chicken, wherein said plurality of pseudogenes are operably linked to said functional IgH gene and donate nucleotide sequences to the nucleic acid of (a) by gene conversion in said transgenic chicken; and wherein said transgenic chicken expresses a polyclonal antisera comprising a diversified IgH variable region.

Metadata:
- Claim Count in Document: 95.0
- Percentile: 98.0
- Lexical Diversity: 2.45
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15377940', '15996373', '14057820', '15188724', '12854722']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6658094557197909
- 35 USC 102 Novelty (BERT): 0.5749252791998571
- Combined Prediction Score: 0.6567210380677976
- Mean Citation Score: 462.989264
- Max Citation Score: 468.82657
- Similarity Product: 388.35375028250456

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test