PATENT CLAIM ANALYSIS

Application Number: 15876960
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-09
Patent Classification: ["514", "252100"]

Abstract:
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

Claim (Index 132):
The method according to  claim 114  wherein the compound of formula (I) is represented by formula (II): Wherein G1 denotes a single bond, G2 denotes a CO group, X is selected from a single bond, an alkylene group having 1 to 6 carbon atoms optionally substituted with 1 or 2 substituents selected from fluoro or C 1 -C 6 -alkyl, Y is selected from an alkylene group having 1 to 6 carbon atoms optionally substituted one or two times with C 3 -C 5 -cycloalkyl or C 1 -C 3 -alkyl; or a 3-8-membered cycloalkylene group, Q is selected from O, NH or a single bond, W is selected from SO, SO 2  or a single bond, U is cycloalkyl, cycloalkenyl, heterocyclyl or heteroaryl, each of the above groups being optionally substituted with 1 to 3 substitutents selected from Hal, NO 2 , CN, \u2014SO 2 \u2014C 1 -C 6 -alkyl, \u2014S\u2014C 1 -C 6 -alkyl, NMe 2 , C 1 -C 6 -alkyl, \u2014C(O)O\u2014C 1 -C 6 -alkyl, O\u2014C 1 -C 6 -alkyl, \u2014(CH 2 ) m \u2014O\u2014C 1 -C 6 -alkyl, \u2014C 1 -C 6 -halo-alkyl, or a 5-6-membered heteroaromatic group being optionally substituted by Hal, V is an aryl group optionally substituted with 1 to 3 substitutents selected from Hal, NO 2 , CN, SO 2 \u2014C 1 -C 6  alkyl, NMe 2 , C 1 -C 6 -alkyl, O\u2014C 1 -C 6 -alkyl, \u2014(CH 2 ) m \u2014O\u2014C 1 -C 6 -alkyl, \u2014C 1 -C 6 -halo-alkyl, O\u2014C 1 -C 6 -halo-alkyl or a 5-6-membered heteroaromatic group, T denotes phenyl, triazolyl, thiazolyl, oxazolyl, oxadiazolyl, or pyrazolyl, R 1  is H, Hal, \u2014C 1 -C 6 -alkyl, O\u2014C 1 -C 6 -alkyl, \u2014(CH 2 ) m \u2014O\u2014C 1 -C 6 -alkyl, O\u2014C 1 -C 6 -halo-alkyl, \u2014(CH 2 ) m \u2014O\u2014C 1 -C 6 -halo-alkyl, \u2014SO 2 \u2014C 1 -C 6 -alkyl, \u2014(CH 2 ) m \u2014SO 2 \u2014C 1 -C 6 -alkyl, \u2014SO 2 \u2014C 1 -C 6 -halo-alkyl, \u2014(CH 2 ) m \u2014SO 2 \u2014C 1 -C 6 -halo-alkyl, \u2014SO 2 -3-8-cycloalkyl, \u2014(CH 2 ) m \u2014SO 2 -3-8-cycloalkyl, cyano or \u2014C 1 -C 6 -halo-alkyl, R 2  and R 2\u2032  are independently from one another H, Hal, \u2014C 1 -C 6 -alkyl, \u2014O\u2014C 1 -C 6 -alkyl, \u2014(CH 2 ) m \u2014O\u2014C 1 -C 6 -alkyl, O\u2014C 1 -C 6 -halo-alkyl, \u2014(CH 2 ) m \u2014O\u2014C 1 -C 6 -halo-alkyl, \u2014SO 2 \u2014C 1 -C 6 -alkyl, \u2014(CH 2 ) m \u2014SO 2 \u2014C 1 -C 6 -alkyl, \u2014SO 2 \u2014C 1 -C 6 -halo-alkyl, \u2014(CH 2 ) m \u2014SO 2 \u2014C 1 -C 6 -halo-alkyl, \u2014SO 2 -3-8-cycloalkyl, \u2014(CH 2 ) m \u2014SO 2 -3-8-cycloalkyl, \u2014C 1 -C 6 -halo-alkyl, or R 1  and R 2  are linked to form with the ring T to which they are attached a 7-12-membered fused heterocyclyl or 7-12-membered fused cycloalkyl, and optionally substituted with 1 to 3 Hal, \u2014C 1 -C 6 -halo-alkyl, NO 2 , CN, a linear or branched alkyl group having 1 to 6 carbon atoms, \u2014(CH 2 ) m \u2014O\u2014C 1 -C 6 -alkyl, or \u2014O\u2014C 1 -C 6 -alkyl, R 3  is C 1 -C 6 -alkyl, R 4  is C 1 -C 6 -alkyl, m is selected from 1, 2, 3 or 4, preferably 1 or 2, Hal is F, Cl, Br, or I, wherein -G 2 -Y\u2014W together is at least 3 atoms in length, or a pharmaceutically acceptable salts thereof, or an enantiomeric mixture of 2 enantiomers in all ratios, and/or as a mixture of diastereoisomers in all ratios.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 86.0
- Lexical Diversity: 1.54762
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14118170', '15366513', '15026740', '13576798', '14322505']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7663179143556619
- 35 USC 102 Novelty (BERT): 0.5496162336628663
- Combined Prediction Score: 0.7446477462863823
- Mean Citation Score: 330.90194
- Max Citation Score: 387.18896
- Similarity Product: 346.3741563919735

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test