PATENT CLAIM ANALYSIS

Application Number: 15908504
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "418000"]

Abstract:
Some embodiments include methods for treating, preventing, reversing, halting, or slowing the progression of cancer, comprising administering to a subject in need thereof an effective amount of one or more chemotherapeutic agents, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition, wherein at least one of the chemotherapeutic agents is a cytotoxic granulocyte colony-stimulating factor receptor (GCFR) modulator. Methods are also disclosed for treating, preventing, reversing, halting, or slowing the progression of a hematopoietic disorder, comprising administered a therapeutically effective cytotoxic amount of a GCFR modulator to a subject in need thereof.

Claim (Index 36):
A method for increasing a blood cell count in a subject comprising administering to a subject in need thereof an effective amount of a compound of Formula (I), (II), III, or (IV): a tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein: R 1  is selected from hydrogen, OR 6 , NO 2 , CN, NR 6 R 7 , CO 2 R 6 , C(\u2550O)NR 6 R 7 , SO 3 R 6 , SO 2 NR 6 R 8 , an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 2 -C 6  alkenyl, an optionally substituted C 2 -C 6  alkynyl, an optionally substituted C 1 -C 6  heteroalkyl, an optionally substituted C 3 -C 6  cycloalkyl, an optionally substituted C 3 -C 6  cycloalkenyl, an optionally substituted C 2 -C 6  heterocyclyl, an optionally substituted arylalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl; R 2  and R 3  are independently selected from hydrogen, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 2 -C 6  alkenyl, an optionally substituted C 2 -C 6  alkynyl, an optionally substituted C 1 -C 6  heteroalkyl, an optionally substituted C 3 -C 8  cycloalkyl, an optionally substituted C 3 -C 8  cycloalkenyl, an optionally substituted C 1 -C 6  heterocycle, an optionally substituted aryl, and an optionally substituted heteroaryl; R 4  is selected from hydrogen, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 2 -C 6  alkenyl, an optionally substituted C 2 -C 6  alkynyl, an optionally substituted C 1 -C 6  heteroalkyl, an optionally substituted C 3 -C 8  cycloalkyl, an optionally substituted C 3 -C 8  cycloalkenyl, an optionally substituted C 1 -C 6  heterocycle, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted arylalkyl, an optionally substituted arylalkenyl, an optionally substituted arylalkynyl, and an optionally substituted heteroarylalkyl; R 5  is selected from hydrogen, halogen, NO 2 , CN, CF 3 , OR 6 , CO 2 R 6 , C(\u2550O)NR 6 R 7 , SO 3 R 6 , and SO 2 NR 6 R 8 , an optionally substituted aryl, an optionally substituted C 1 -C 6  alkyl, and an optionally substituted C 1 -C 6  heteroalkyl; R 6  is selected from hydrogen, an optionally substituted C 1 -C 6  alkyl, a C 1 -C 6  heteroalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl; R 7  is selected from hydrogen, C(\u2550O)R 8 , C(\u2550O)NHR 8 , an optionally substituted C 1 -C 6  alkyl, and an optionally substituted C 1 -C 6  heteroalkyl; or \u2014NR 6 R 7  is an optionally substituted non-aromatic heterocycle linked through a ring nitrogen; R 8  is selected from hydrogen, an optionally substituted C 1 -C 6  alkyl, and an optionally substituted C 1 -C 6  heteroalkyl; R 9  is selected from hydrogen, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 2 -C 6  alkenyl, an optionally substituted C 2 -C 6  alkynyl, an optionally substituted C 1 -C 6  heteroalkyl, an optionally substituted C 3 -C 8  cycloalkyl, an optionally substituted C 3 -C 8  cycloalkenyl, an optionally substituted C 1 -C 6  heterocycle, an optionally substituted heteroaryl, an optionally substituted arylalkyl, an optionally substituted arylalkenyl, an optionally substituted arylalkynyl, an optionally substituted heteroarylalkyl, an optionally substituted heteroarylalkenyl, and an optionally substituted heteroarylalkynyl; Q is selected from the group consisting of NR 6 , an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 3 -C 8  cycloalkyl, an optionally substituted C 1 -C 6  heteroalkyl, and an optionally substituted non-aromatic heterocycle; L 1  is selected from NH and CHR 2 ; W is selected from O (oxygen) and NH; X is N (nitrogen) or CR 2 ; Y is selected from an optionally substituted C 1 -C 6  alkyl, C 2 -C 6  alkenyl, an optionally substituted C 1 -C 6  heteroalkyl, an optionally substituted C 1 -C 6  heteroalkenyl, an optionally substituted phenylalkenyl, and an optionally substituted heterocyclealkenyl; Z is O (oxygen) or S (sulfur); and n is 1, 2 or 3.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 88.0
- Lexical Diversity: 1.89655
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14775587', '14357551', '15247164', '14977011', '15648349']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7769913190546943
- 35 USC 102 Novelty (BERT): 0.5570706764147106
- Combined Prediction Score: 0.754999254790696
- Mean Citation Score: 341.537702
- Max Citation Score: 434.3427400000001
- Similarity Product: 361.1686970403219

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test