PATENT CLAIM ANALYSIS

Application Number: 15752144
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "047000"]

Abstract:
A class of polycyclic compounds of general formula (II), of general formula (II′), or of general formula (II″), wherein Base 1 , Base 2 , Y, Y a , X a , X a1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3a , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , and R 8a  are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Claim (Index 10):
The compound according to  claim 8 , or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein\n Base 1  and Base 2  are each independently selected from the group consisting of where Base 1  and Base 2  each may be independently substituted by 0-3 substituents R 10 , where each R 10  is independently selected from the group consisting of F, Cl, I, Br, OH, SH, NH 2 , C 1-3  alkyl, C 3-6  cycloalkyl, O(C 1-3  alkyl), O(C 3-6  cycloalkyl), S(C 1-3  alkyl), S(C 3-6  cycloalkyl), NH(C 1-3  alkyl), NH(C 3-6  cycloalkyl), N(C 1-3  alkyl) 2 , and N(C 3-6  cycloalkyl) 2 ;\n Y and Y a  are each independently selected from the group consisting of \u2014O\u2014 and \u2014S\u2014; \n X a  and X a1  are each independently selected from the group consisting of O and S; \n X b  and X b1  are each independently selected from the group consisting of O and S; \n X c  and X c1  are each independently selected from the group consisting of SR 9 , OR 9 , and NR 9 R 9 ; \n X d  and X d1  are each independently selected from the group consisting of O and S; \n R 1  and R 1a  are each H; \n R 2  and R 2a  are each independently selected from the group consisting of H, F, Cl, Br, I, OH, N 3 , C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl, where said R 2  and R 2a C 1 -C 6  alkyl or C 1 -C 6  haloalkyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N 3 ; \n R 3a  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N 3 , C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl, where said R 3a C 1 -C 6  alkyl or C 1 -C 6  haloalkyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N 3 ; \n R 4  and R 4a  are each independently selected from the group consisting of H, F, Cl, Br, I, OH, C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl, where said R 4  and R 4a C 1 -C 6  alkyl or C 1 -C 6  haloalkyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N 3 ; \n R 5  is selected from the group consisting of H, F, Cl, Br, I, OH, NH 2 , N 3 , C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl, where said R 5 C 1 -C 6  alkyl or C 1 -C 6  haloalkyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N 3 ; \n R 3a  and R 5  are not both selected from the group consisting of: OH, C 1 -C 6  alkyl substituted with OH, or C 1 -C 6  haloalkyl substituted with OH; and \n R 6  and R 6a  are each independently selected from the group consisting of H, F, Cl, Br, I, OH, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, and C 1 -C 6  haloalkyl, where said R 6  and R 6a C 1 -C 6  alkyl or C 1 -C 6  haloalkyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N 3 ; \n R 7  and R 7a  are each H; \n R 8  and R 8a  are each H; \n each R 9  is independently selected from the group consisting of H, C 2 -C 3  alkyl, \n where each R 9 C 2 -C 3  alkyl is optionally substituted by 1 to 2 substituents independently selected from the group consisting of OH, \u2014O\u2014C 1 -C 20  alkyl, \u2014S\u2014C(O)C 1 -C 6  alkyl, and C(O)OC 1 -C 6  alkyl;\n optionally R 3a  and R 6a  are connected to form \u2014O\u2014C 1 -C 6  alkylene, \u2014O\u2014C 2 -C 6  alkenylene, and \u2014O\u2014C 2 -C 6  alkynylene, such that where R 3a  and R 6a  are connected to form \u2014O\u2014C 1 -C 6  alkylene, \u2014O\u2014C 2 -C 6  alkenylene, or \u2014O\u2014C 2 -C 6  alkynylene, said O is bound at the R 3a  position; and \n optionally R 4  and R 5  are connected by C 1 -C 6  alkylene, \u2014O\u2014C 1 -C 6  alkylene, \u2014O\u2014C 2 -C 6  alkenylene, or \u2014O\u2014C 2 -C 6  alkynylene, such that where R 4  and R 5  are connected to form \u2014O\u2014C 1 -C 6  alkylene, \u2014O\u2014C 2 -C 6  alkenylene, or \u2014O\u2014C 2 -C 6  alkynylene, said O is bound at the R 5  position.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 88.0
- Lexical Diversity: 2.1194
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15586634', '15368921', '15234182', '15315458', '15543007']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8196146077928547
- 35 USC 102 Novelty (BERT): 0.5267054433678097
- Combined Prediction Score: 0.7903236913503502
- Mean Citation Score: 311.508158
- Max Citation Score: 339.67236
- Similarity Product: 211.0863333331346

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test