PATENT CLAIM ANALYSIS

Application Number: 16005488
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "230500"]

Abstract:
The present invention provides compounds represented by formula (I), pharmaceutically acceptable salts thereof, N-oxides thereof, solvates thereof or prodrugs thereof (wherein the characters are as defined in the description). The compounds represented by formula (I) have affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 (GABA A  α5) and act as GABA A  α5 negative allosteric modulators (GABA A  α5 NAM), so that they are useful in the prevention and/or treatment of diseases which are related to the GABA A  α5 such as Alzheimer's disease.

Claim (Index 13):
The compound according to  claim 1 , wherein the compound is selected from the group consisting of\n (1) 4-Cyclopropyl-7-((1-(cyclopropylmethyl)-1H-imidazo[4,5-c]pyridin-6-yl)amino)-2H-benzo[b][1,4]oxazin-3 (4H)-one, (4) 7-((9-(Cyclopropylmethyl)-9H-purin-2-yl)amino)-4-(2-methoxyethyl)-2H-benzo[b][1,4]oxazin-3 (4H)-one, (5) 7-((1-((3,3-Difluorocyclobutyl)methyl)-5-fluoro-1H-benzo[d]imidazol-6-yl)amino)-4-methyl-2H-pyrido[3,2-b][1,4]oxazin-3 (4H)-one, (6) 6-((1-((3,3-Difluorocyclobutyl)methyl)-4-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)-3-methylbenzo[d]oxazol-2(3H)-one, (7) 7-((1-(2-Cyclopropylethyl)-5-fluoro-1H-benzo[d]imidazol-6-yl)amino)-4-methyl-2H-pyrido[3,2-b][1,4]oxazin-3 (4H)-one, (8) 7-((1-(Cyclopropylmethyl)-5-fluoro-4-methyl-1H-benzo[d]imidazol-6-yl)amino)-4-methyl-2H-pyrido[3,2-b][1,4]oxazin-3 (4H)-one, (9) 7-((1-(Cyclopropylmethyl)-5-fluoro-4-methyl-1H-benzo[d]imidazol-6-yl)amino)-4-methyl-2H-pyrido[4,3-b][1,4]oxazin-3 (4H)-one, (10) N-(6-(1H-Imidazol-1-yl)pyridin-3-yl)-1-(cyclopropylmethyl)-5-fluoro-4-methyl-1H-benzo[d]imidazol-6-amine, (11) 1-(Cyclopropylmethyl)-4,5-difluoro-N-(3-fluoro-4-(1H-imidazol-1-yl)phenyl)-1H-benzo[d]imidazol-6-amine, (13) 7-((1-(Cyclopropylmethyl)-4-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)-4-methyl-2H-benzo[b][1,4]oxazin-3 (4H)-one, (14) 7-((1-Butyl-4-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)-4-methyl-2H-benzo[b][1,4]oxazin-3 (4H)-one, (15) 7-((1-(Cyclopropylmethyl)-4-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)-4-methyl-2H-pyrido[3,2-b][1,4]oxazin-3 (4H)-one, (16) 6-((1-(Cyclopropylmethyl)-4-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)-1-methyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one, (17) 7-((9-(Cyclopropylmethyl)-6-methyl-9H-purin-2-yl)amino)-4-ethyl-2H-benzo[b][1,4]oxazin-3 (4H)-one,

Metadata:
- Claim Count in Document: 27.0
- Percentile: 94.0
- Lexical Diversity: 1.64062
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15112647', '14208067', '14376307', '10149852', '11942480']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8368438401738538
- 35 USC 102 Novelty (BERT): 0.5799702866776857
- Combined Prediction Score: 0.8111564848242371
- Mean Citation Score: 380.78577
- Max Citation Score: 515.1568
- Similarity Product: 403.13234957590106

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test