PATENT CLAIM ANALYSIS

Application Number: 15919866
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "186100"]

Abstract:
Methods for generating antibodies to immuno-subdominant epitopes of elusive pathogens and vaccines and methods of vaccinating subjects against elusive pathogens are disclosed. The methods include targeting immunodominant B cells to undergo apoptosis, for example, while simultaneously targeting the germinal center (GC) reaction toward preferential selection and differentiation of B cells that produce broadly neutralizing antibody against a targeted pathogen.

Claim (Index 19):
A method of generating therapeutic antibodies to a specific epitope of a therapeutic target, comprising the steps of:\n (1) administering a primary immunization composition to a mammal, said primary immunization composition comprising a recombinant peptide comprising the epitope of the therapeutic target; (2) administering to the subject a composition comprising an inhibitory construct comprising at least one copy of an altered form of the recombinant peptide, wherein the altered form comprises at least one amino acid change or structural alteration of the epitope that prevents binding of antibody thereto; and wherein the inhibitory construct is administered separately from and prior to, concurrently with or within two months of administration of the primary immunization composition; (3) Isolating one or more B cells from said mammal;\n wherein an antibody expressed by the one or more B cells comprises a variable domain and said antibody binds to the epitope; and \n (4) Identifying the nucleic acid sequence that encodes the variable domain of said antibody and utilizing said sequence to generate a recombinant version of the antibody.

Metadata:
- Claim Count in Document: 45.0
- Percentile: 90.0
- Lexical Diversity: 1.3
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13989176', '13262285', '14777605', '11962007', '15512820']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7549014234547321
- 35 USC 102 Novelty (BERT): 0.52265752146105
- Combined Prediction Score: 0.7316770332553638
- Mean Citation Score: 315.343366
- Max Citation Score: 333.24872
- Similarity Product: 227.7749213866329

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test