PATENT CLAIM ANALYSIS

Application Number: 16115059
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["435", "006100"]

Abstract:
A system and method for isolating and analyzing single cells, wherein the system includes: an array of wells defined at a substrate, each well including an open surface and a well cavity configured to capture cells in one of a single-cell format and single-cluster format, and a fluid delivery module including a fluid reservoir superior to the array of wells through which fluid flow is controlled along a fluid path in a direction parallel to the broad face of the substrate; and wherein the method includes: distributing a population of cells and a population of non-cell particles across the array of wells through the fluid reservoir to increase capture efficiency of individual cell-particle pairs within the array of wells, and processing the captured cell-particle pairs at the set of wells.

Claim (Index 2):
A method for isolating and analyzing a population of target cells comprising:\n receiving a population of target cells into an array of wells defined at a surface plane of a substrate, wherein each well in the array of wells extends perpendicular to and below the surface plane within the substrate; achieving a particle-accessible state for a first subset of wells of the array of wells, wherein a first well of the first subset of wells receives a first target cell of the population of target cells below the surface plane through an open end of the first well; after receiving the population of target cells into the array of wells, distributing a population of particles into the array of wells, wherein each particle of the population of particles is coupled to a probe having a binding affinity for a biomolecule associated with the population of target cells; upon distributing the population of particles into the array of wells,\n achieving a particle-saturated state for at least the first well of the first subset of wells, wherein achieving the particle-saturated state comprises receiving, into the first well, a first particle below the surface plane and a partially retained particle traversing the surface plane; \n re-distributing a subset of partially retained particles across the array of wells, wherein each partially retained particle in the subset of partially retained particles traverses the surface plane, wherein re-distributing the subset of partially retained particles comprises:\n flowing a particle distribution fluid along a fluid path through a fluid reservoir spanning the array of wells along the surface plane and in a direction parallel to the surface plane, wherein the particle distribution fluid egresses the partially retained particle traversing the surface plane from the first well, thereby transitioning the first well from the particle-saturated state to an ideal state; and \n processing a set of ideal wells of the array of wells comprising at least the first well, wherein each well in the set of ideal wells is in the ideal state and contains exactly one target cell of the population of target cells and exactly one particle of the population of particles.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 96.0
- Lexical Diversity: 2.02941
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16115370', '16049173', '16049240', '15821329', '14289155']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5879199923755117
- 35 USC 102 Novelty (BERT): 0.5324998146401739
- Combined Prediction Score: 0.5823779746019779
- Mean Citation Score: 287.723346
- Max Citation Score: 357.30707
- Similarity Product: 271.6030773661888

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test