PATENT CLAIM ANALYSIS

Application Number: 16107762
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["546", "304000"]

Abstract:
Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.

Claim (Index 1):
A compound of the formula: wherein:\n A is a carbon, or A, R 5 , and R 6  are absent; \n R 1 , R 2 , R 3 , and R 4 , are independently selected from hydrogen, halogen, \u2014SO 3 X, a carboxylic acid, a salt of carboxylic acid, CN, nitro, hydroxyl, amino, hydrazine, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocycloalkyl, alkoxy, substituted alkoxy, alkylthio, alkanoylamino, alkylaminocarbonyl, aryl, heteroaryl, substituted aryl, arylalkyl, substituted arylalkyl, substituted heteroaryl, and arylcarboxamido; \n R 5 , and R 6 , are hydrogen; at least one substituent selected from R 1 , R 2 , R 3 , R 4 , R 5  and R 6  comprises X-L-, wherein:\n X is selected from a reporter molecule, a carrier molecule, a solid phase, a therapeutic molecule, and a reactive group, that are optionally bound to one or more additional fluorophores, wherein:\n the therapeutic molecule is a peptide, a protein, an antibody, a polysaccharide, a nucleic acid polymer, an ion complexing moiety, a lipid, a non-biological organic polymer, a polymeric micro particle or a polymeric nanoparticle, and \n the reactive group is a carboxylic acid, an activated ester of carboxylic acid, an amine, a hydrazine, a haloacetamide, an alkyl halide, an isothiocynate or a maleimide group; and \n \n L is an independently a single covalent bond or L is covalent linkage having 1-24 non-hydrogen atoms selected from the group consisting of C, N, O, P and S and composed of any combinations of single, double, triple or aromatic carbon-carbon bonds, carbon-nitrogen bonds, nitrogen-nitrogen bonds, carbon-oxygen bonds, carbon-sulfur bonds, phosphorus-oxygen bonds and phosphorus-nitrogen bonds in the form of alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkoxy, substituted alkoxy, substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocycloalkyl, aryl, heteroaryl, substituted aryl, arylalkyl, substituted arylalkyl, and substituted heteroaryl; \n Z is an independently a single covalent bond or Z is covalent linkage having 1-10 non-hydrogen atoms selected from the group consisting of C, N, O, P and S and composed of any combinations of single, double, triple or aromatic carbon-carbon bonds, carbon-nitrogen bonds, carbon-oxygen bonds, and carbon-sulfur bonds in the form of a straight- or branched-chain alkyl or heteroalkyl chain; and G is a chemical handle selected from an azide-reactive group, an alkyne-reactive group, and a phosphine-reactive group.

Metadata:
- Claim Count in Document: 52.0
- Percentile: 96.0
- Lexical Diversity: 1.65217
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13902076', '13859627', '14662397', '15194911', '11005860']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8085125527079892
- 35 USC 102 Novelty (BERT): 0.5199005047947441
- Combined Prediction Score: 0.7796513479166647
- Mean Citation Score: 325.18230000000005
- Max Citation Score: 328.18896
- Similarity Product: 266.7587908963108

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test