PATENT CLAIM ANALYSIS

Application Number: 15751163
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["546", "115000"]

Abstract:
The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases.

Claim (Index 3):
The compound of  claim 1 , wherein\n each R 6 , R 6a , R 3 , R 3a , R 2 , R 2a , R 8a , R 10 , R 10a , R 12  and R 12a  is independently H, methyl, ethyl, n-propyl, isopropyl, 1-methylpropyl, 2-methylpropyl or tert-butyl, wherein each of the methyl, ethyl, n-propyl, isopropyl, 1-methylpropyl, 2-methylpropyl and tert-butyl is independently and optionally substituted with 1, 2, 3, 4, 5 or 6 substituents selected from F, Cl, Br, hydroxy, amino, carboxy, cyano, cyclohexyl, cyclopentyl, cyclobutyl, cyclopropyl, phenyl, pyridyl, thiazolyl, diazolyl, triazolyl, piperidyl, furyl, tetrahydrofuryl, azetanyl, oxetanyl and morpholinyl; or, R 2  and R 2a , together with the carbon atom to which they are attached, form a cyclohexyl, cyclopentyl, cyclobutyl, cyclopropyl, cycloheptyl, piperidyl, pyrrolidyl, piperazinyl, tetrahydropyranyl, morpholinyl or tetrahydrofuryl group, wherein each of the cyclohexyl, cyclopentyl, cyclobutyl, cyclopropyl, cycloheptyl, piperidyl, pyrrolidyl, piperazinyl, tetrahydropyranyl, morpholinyl and tetrahydrofuryl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from C 1-4  alkyl, C 2-4  alkenyl, C 1-4  hydroxyalkyl, C 1-4  haloalkyl, hydroxy, amino, carboxy, cyano, F, Cl and Br; or, R 3  and R 3a , together with the carbon atom to which they are attached, form a >C(\u2550O), cyclohexyl, cyclopentyl, cyclobutyl, cyclopropyl, cycloheptyl, piperidyl, pyrrolidyl, piperazinyl, tetrahydropyranyl, morpholinyl or tetrahydrofuryl group, wherein each of the cyclohexyl, cyclopentyl, cyclobutyl, cyclopropyl, cycloheptyl, piperidyl, pyrrolidyl, piperazinyl, tetrahydropyranyl, morpholinyl and tetrahydrofuryl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from C 1-4  alkyl, C 1-4  hydroxyalkyl, C 1-4  haloalkyl, hydroxy, amino, carboxy, cyano and halogen.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.42222
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12734224', '14647445', '14397200', '15580978', '14894817']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8213153617144856
- 35 USC 102 Novelty (BERT): 0.5303738441172146
- Combined Prediction Score: 0.7922212099547585
- Mean Citation Score: 341.089354
- Max Citation Score: 366.94565
- Similarity Product: 272.616679674986

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test