PATENT CLAIM ANALYSIS

Application Number: 15909200
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["514", "260100"]

Abstract:
The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R 1 , R 2 , R 3 , R 5 , R 5′ , X 1 , X 2 , n, and m are described herein.

Claim (Index 19):
The compound of  claim 1 , having Formula (Ii): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, and tautomer thereof, wherein: R 2  is (C 1 -C 6 ) alkyl, (C 6 -C 14 ) aryl, heteroaryl, (C 5 -C 8 ) cycloalkyl, heterocycloalkyl, \u2014NR 10 R 11 , or \u2014OR 10 , wherein the alkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R 8 ; R 4  is (C 1 -C 6 ) alkyl, (C 6 -C 14 ) aryl, heteroaryl, (C 5 -C 8 ) cycloalkyl, or heterocycloalkyl, wherein the alkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R 12 ; each R 8  is independently D, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, CN, \u2014(C 1 -C 3 )-alkylene-O\u2014(C 1 -C 6 ) alkyl, \u2014(C 0 -C 4 )-alkylene-aryl, \u2014(C 0 -C 4 )-alkylene-heteroaryl, (C 3 -C 10 ) cycloalkyl, heterocycloalkyl, \u2014(C 0 -C 4 )-alkylene-O-aryl, \u2014(C 0 -C 4 )-alkylene-O-heteroaryl, \u2014O\u2014(C 3 -C 8 )cycloalkyl, \u2014S-heteroaryl, \u2014C(O)R 21 , \u2014CO(O)R 21 , \u2014C(O)NR 21 R 22 , \u2014S(O) q R 21 , \u2014S(O) q NR 21 R 22 , \u2014NR 21 S(O) q R 22 , \u2014(C 0 -C 3 )-alkylene-NR 21 R 22 , \u2014NR 21 C(O)R 22 , \u2014NR 21 C(O)C(O)R 22 , \u2014NR 21 C(O)NR 21 R 22 , \u2014P(O)((C 1 -C 6 ) alkyl) 2 , \u2014P(O)(aryl) 2 , \u2014SiMe 3 , \u2014SF 5 , or \u2014OR 21 , wherein the alkyl, alkylene, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R 9 ; or two R 8  together when on adjacent atoms form a (C 3 -C 8 ) cycloalkyl optionally substituted with one or more R 9 ; or two R 8  together when on adjacent atoms form a heterocycloalkyl ring optionally substituted with one or more R 9 ; or two R 8  together when on adjacent atoms form an aryl ring optionally substituted with one or more R 9 ; or two R 8  together when on adjacent atoms form an heteroaryl ring optionally substituted with one or more R 9 ; each R 9  is independently (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, (C 3 -C 8 ) cycloalkyl, heterocycloalkyl, (C 6 -C 14 ) aryl, heteroaryl, \u2014NH 2 , \u2014OH, \u2014C(O)R 23 , \u2014C(O)NR 23 R 24 , \u2014NR 23 C(O)R 24 , \u2014NR 23 R 24 , \u2014S(O) q R 23 , \u2014S(O) q NR 23 R 24 , \u2014NR 23 S(O) q R 24 , Oxo, \u2014P(O)((C 1 -C 6 ) alkyl) 2 , \u2014P(O)(aryl) 2 , \u2014SiMe 3 , \u2014SF 5 , \u2014O-aryl, CN, or \u2014O-heteroaryl, wherein the alkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R 26 ; R 10  and R 11  are independently H, (C 1 -C 6 ) alkyl, (C 6 -C 14 ) aryl, heteroaryl, (C 5 -C 8 ) cycloalkyl, or heterocycloalkyl, wherein the alkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R 18 ; or R 10  and R 11  together with the nitrogen to which they are attached form a heterocycloalkyl ring optionally substituted with one or more R 18 ; each R 12  is independently D, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, CN, \u2014OH, \u2014NH 2 , \u2014C(O)(C 1 -C 6 ) alkyl, \u2014S(O) q (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkylamino, di(C 1 -C 6 ) alkylamino, (C 6 -C 14 ) aryl, heteroaryl, (C 3 -C 8 ) cycloalkyl, heterocycloalkyl, \u2014O-aryl, \u2014O-heteroaryl, \u2014O-heterocycloalkyl, \u2014O\u2014(C 3 -C 8 )cycloalkyl, \u2014C(O)O(C 1 -C 6 ) alkyl, \u2014C(O)NR 27 R 28 , \u2014S(O) q NR 27 R 28 , \u2014NR 27 R 28 , \u2014NR 27 C(O)NR 27 R 28 , \u2014NR 27 C(O)OR 28 , \u2014NR 27 S(O) q R 28 , \u2014NR 27 C(O)R 28 , halogen, \u2014P(O)((C 1 -C 6 ) alkyl) 2 , \u2014P(O)(aryl) 2 , \u2014SiMe 3 , or \u2014SF 5 , wherein in the alkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R 13 ; or two R 12  together when on adjacent atoms form a (C 3 -C 8 ) cycloalkyl optionally substituted with one or more R 13 ; or two R 12  together when on adjacent atoms form a heterocycloalkyl ring optionally substituted with one or more R 13 ; or two R 12  together when on adjacent atoms form an aryl ring optionally substituted with one or more R 13 ; or two R 12  together when on adjacent atoms form an heteroaryl ring optionally substituted with one or more R 13 ; each R 13  is independently (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, \u2014C(O)(C 1 -C 6 ) alkyl, \u2014S(O) q (C 1 -C 6 ) alkyl, \u2014NH 2 , (C 1 -C 6 ) alkylamino, di(C 1 -C 6 ) alkylamino, (C 6 -C 14 ) aryl, heteroaryl, (C 3 -C 8 ) cycloalkyl, heterocycloalkyl, \u2014O-aryl, \u2014O-heteroaryl, \u2014O-heterocycloalkyl, \u2014O\u2014(C 3 -C 8 )cycloalkyl, \u2014OH, or CN, wherein in the alkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R 29 ; each R 18  is independently (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, (C 1 -C 6 ) hydroxyalkyl, \u2014OH, CN, \u2014C(O)(C 1 -C 6 ) alkyl, \u2014S(O) q (C 1 -C 6 ) alkyl, \u2014NH 2 , (C 1 -C 6 ) alkylamino, di(C 1 -C 6 ) alkylamino, (C 6 -C 14 ) aryl, heteroaryl, (C 5 -C 8 ) cycloalkyl, or heterocycloalkyl, wherein in the alkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R 19 ; each R 19  is independently (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, \u2014C(O)(C 1 -C 6 ) alkyl, \u2014S(O) q (C 1 -C 6 ) alkyl, \u2014NH 2 , (C 1 -C 6 ) alkylamino, di(C 1 -C 6 ) alkylamino, \u2014OH, or CN; each R 21  and R 22  is independently H, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, (C 6 -C 14 ) aryl, heteroaryl, (C 5 -C 8 ) cycloalkyl, or heterocycloalkyl, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl are optionally substituted with one or more R 25 ; each R 23  and R 24  is independently H, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, (C 6 -C 14 ) aryl, heteroaryl, (C 5 -C 8 ) cycloalkyl, or heterocycloalkyl, wherein the alkyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl are optionally substituted with one or more R 25 ; each R 25  is independently at each occurrence (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, \u2014NH 2 , (C 1 -C 6 ) alkylamino, di(C 1 -C 6 ) alkylamino, \u2014OH, or CN; each R 26  is independently at each occurrence (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, \u2014NR 27 C(O)R 28 , \u2014NR 27 S(O) q R 28 , \u2014C(O)R 27 , \u2014C(O)NR 27 R 28 , \u2014NR 27 R 28 , \u2014S(O) q R 27 , \u2014S(O) q NR 27 R 28 , \u2014P(O)((C 1 -C 6 ) alkyl) 2 , \u2014P(O)(aryl) 2 , \u2014SiMe 3 , \u2014SF 5 , \u2014OH, or CN; each R 27  and R 28  is independently at each occurrence H, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl, (C 6 -C 14 ) aryl, heteroaryl, (C 5 -C 8 ) cycloalkyl, or heterocycloalkyl, wherein the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl are optionally substituted with one or more substituents independently selected from (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, \u2014NH 2 , (C 1 -C 6 ) alkylamino, or di(C 1 -C 6 ) alkylamino; each R 29  is independently at each occurrence (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, \u2014C(O)(C 1 -C 6 ) alkyl, \u2014S(O) q (C 1 -C 6 ) alkyl, \u2014NH 2 , (C 1 -C 6 ) alkylamino, di(C 1 -C 6 ) alkylamino, \u2014OH, or CN; and q is independently at each occurrence 0, 1, or 2.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 90.0
- Lexical Diversity: 1.82927
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15015563', '15015571', '15015566', '15837393', '14982131']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8822589418356342
- 35 USC 102 Novelty (BERT): 0.6985975060918764
- Combined Prediction Score: 0.8638927982612585
- Mean Citation Score: 632.843572
- Max Citation Score: 682.53766
- Similarity Product: 638.6777045418382

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test