PATENT CLAIM ANALYSIS

Application Number: 16014878
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-05
Patent Classification: ["435", "007100"]

Abstract:
The present invention relates to a piezoelectric mechanical system (PEMS) microcantilever sensor that both detects the presence of viral RNA in an aqueous solution, such as a blood sample. The method provides for the formation of the sensor by attaching RNA, DNA, or an antibody to the microcantilever sensor surface via a hydrazone or an oxime chemical bond. The method provides for the detection of viral RNA viruses and viral DNA viruses upon the chemical binding/bonding of single-stranded viral nucleic acid to the microcantilever sensor surface. The method provides for the detection of DNA cancer mutations or variants that have been identified in a cancer cell upon the chemical binding/bonding of single-stranded DNA to the microcantilever sensor surface.

Claim (Index 16):
A piezoelectric microcantilever sensor array for detecting a biomolecule in an aqueous solution comprising:\n a reference piezoelectric microcantilever sensor comprised of silicon, silicon nitride, or a polmer; wherein the reference piezoelectric microcantilever sensor does not bond with the biomolecule; a test piezoelectric microcantilever sensor comprised of silicon, silicon nitride, or a polymer; wherein the test piezoelectric microcantilever sensor includes a binding area, wherein the binding area has been chemically modified so that an agent that bonds with the biomolecule is bound to the binding area;\n wherein the agent that bonds with the biomolecule is bound onto the binding area via a carbon atom on a surface of the agent that bonds with the biomolecule and a nitrogen atom on a surface of the binding area via a chemical bond, wherein the chemical bond is not an amine bond; \n an electrical input that enters the reference piezoelectric microcantilever sensor and an electrical output that exits the reference piezoelectric microcantilever sensor; a means of detecting the electrical output of the reference piezoelectric microcantilever sensor; an electrical input that enters the test piezoelectric microcantilever sensor and an electrical output that exits the test microcantilever sensor; and a means of detecting the electrical output of the test piezoelectric microcantilever sensor.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 94.0
- Lexical Diversity: 2.04839
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12514941', '14551710', '11946534', '13160304', '12900160']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5742380299751941
- 35 USC 102 Novelty (BERT): 0.4923620416697652
- Combined Prediction Score: 0.5660504311446513
- Mean Citation Score: 210.6505
- Max Citation Score: 230.83936
- Similarity Product: 162.6071534502983

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test