PATENT CLAIM ANALYSIS

Application Number: 15986727
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "476000"]

Abstract:
In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a toxin including an acylfulvene or a drug moiety. The affinity moiety can be an antibody, a binding protein, a steroid, a lipid, a growth factor, a protein, a peptide or non peptidic. The affinity moiety can be covalently bound to the medicant via a linker. Novel linkers that can be directed to cysteine, arginine or lysine residues based on solution pH allow greater flexibility in preserving and/or generating specific epitopes in the AMC.

Claim (Index 6):
The compound of  claim 1 , where R 6  is selected from the group consisting of elaidic acid, glutaryl, 2-aminoisobutyric acid, \u03b2-amino-n-butyric acid, \u03b2-aminoisobutyric acid, \u03b3-aminobutyric acid, cystathione, delta-aminolevulinic acid, 4-aminobenzoic acid, djenkolic acid, hypusine, penicillamine, quisqualic acid, carbohydrazide 1,3-diaminourea, N,N\u2032-carbonyldiimidazole, N,N\u2032-disuccinimidyl carbonate, N-hydroxysuccinimidyl chloroformate, succinimidyl 3-bromoacetamido) propionate, 1,4-bis-maleimidobutane, 1,4-bis-maleimidyl-2,3-dihydroxybutyrate, bis-maleimidehexane, bis-maleimideethane, 1, 8-bis-malemidodiethyene-glycol, 1, 11-bis-malemidotriethyene-glycol, 1,4-di(3\u2032-(2\u2032pyridyldithio) propionamido) butane, 1,6-hexane-bis-vinylsulfone, N-(4-(p-azidosalicylamido) butyl)-3\u2032-(2\u2032-pyridyldithio) propionamide, N-(episilon-maleimidocaproic acid).

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 1.66176
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15201301', '14684218', '14875476', '13397205', '11342937']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8493686797917515
- 35 USC 102 Novelty (BERT): 0.6276086210265374
- Combined Prediction Score: 0.8271926739152301
- Mean Citation Score: 491.007214
- Max Citation Score: 758.3846
- Similarity Product: 509.3499351070523

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test