PATENT CLAIM ANALYSIS

Application Number: 16243091
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2020-02
Patent Classification: ["null", "null"]

Abstract:
A method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine is provided. The method comprises the steps of: preparing methyl p-bromophenylacetate (Intermediate I) by catalytic esterification of p-bromophenylacetic acid, and then reacting with dimethyl carbonate to synthesize 2-(4-bromophenyl)-malonic acid-1,3-dimethyl ester (Intermediate 2), cyclizing with formamidine hydrochloride to obtain 5-(4-bromophenyl)-4,6-dihydroxypyrimidine (Intermediate 3), and then chlorinating to give the product 5-(4-bromophenyl)-4,6-dichloropyrimidine. In the process of preparing Intermediate 1 in the present invention, a solid acid is used as a catalyst. Moreover, in the process of preparing Intermediate 2, sodium methoxide is used as a base in place of sodium hydride or sodium amide used in the prior art. Furthermore, Intermediate 3 is prepared by a one-pot process.

Claim (Index 5):
The method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine according to  claim 1 , wherein the post-treatment in Step 3 comprises:\n Step (a): adding water to the reaction solution, stirring at 20-30\u00b0 C. until the reaction solution becomes clear, and standing for layering; Step (b): collecting the aqueous phase, adjusting to pH 4-6 with an acidic solution, and stirring for 0.5-1.5 hours; and Step (c): filtering under suction, washing the obtained filter cake with an 80 wt % aqueous methanol solution, and drying to obtain Intermediate 3.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 99.0
- Lexical Diversity: 1.95946
- Patent Class: nan
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13521780', '15535413', '15521021', '14399929', '14673427']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5589380378048135
- 35 USC 102 Novelty (BERT): 0.48959239605485
- Combined Prediction Score: 0.5520034736298172
- Mean Citation Score: 222.156194
- Max Citation Score: 235.4971
- Similarity Product: 181.84485016344783

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test