PATENT CLAIM ANALYSIS

Application Number: 15866044
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["424", "094600"]

Abstract:
This invention relates, in part, to various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.

Claim (Index 77):
A method for producing an antibiotic-degrading agent in  Escherichia coli  ( E. coli ), comprising:\n (a) providing a host  E. coli  cell transformed with a vector comprising a sequence encoding the antibiotic-degrading agent; (b) culturing the  E. coli  cell to induce expression of the antibiotic-degrading agent; and (c) recovering the antibiotic-degrading agent from a soluble fraction prepared from the  E. coli  cell, wherein: the antibiotic-degrading agent is broad spectrum carbapenemase comprising at least 95% sequence identity with the amino acid sequence of SEQ ID NO: 68 or SEQ ID NO: 53 and the culturing is in the presence of an amount of zinc sufficient to substantially increase the amount of antibiotic-degrading agent protein in a soluble fraction and reduce the amount of antibiotic-degrading agent protein in inclusion bodies relative to culturing in the absence of zinc.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 86.0
- Lexical Diversity: 1.05
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14878155', '14676559', '15641806', '14757522', '15138767']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6456746765983475
- 35 USC 102 Novelty (BERT): 0.5010220996812352
- Combined Prediction Score: 0.6312094189066363
- Mean Citation Score: 193.146484
- Max Citation Score: 211.20166
- Similarity Product: 143.86601951965568

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test