PATENT CLAIM ANALYSIS

Application Number: 15894077
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["435", "006100"]

Abstract:
A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

Claim (Index 1):
A screening method for the identification of a disease state, comprising the steps of:\n a. contacting a drawn blood sample that includes a plurality of blood cells with a plasma RNA protective agent in an amount and for a time sufficient so that RNA synthesis is inhibited for at least two hours; blood cells of the drawn blood sample are fixed to substantially prevent leaking of cellular RNA into the plasma; any cellular RNA that is within the blood cells at the time of the blood draw is substantially preserved to immobilize the protein expression pattern of the blood cells so that the protein expression pattern of the cells remains substantially the same as at the time of the blood draw; and cell-free RNA that is in the plasma is substantially stabilized against degradation mediated by the combined action of nucleases and proteases; b. isolating the cell-free RNA from the blood sample; and c. analyzing (e.g., by quantity, quality, or both) the isolated RNA for the presence, absence, or severity of a disease state.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 88.0
- Lexical Diversity: 1.6
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12704030', '14071969', '15601682', '13648415', '14907167']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6304562476119984
- 35 USC 102 Novelty (BERT): 0.556173497096565
- Combined Prediction Score: 0.6230279725604551
- Mean Citation Score: 323.881426
- Max Citation Score: 375.95297
- Similarity Product: 255.37705818429885

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test