PATENT CLAIM ANALYSIS

Application Number: 16137262
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["564", "135000"]

Abstract:
The present invention includes methods for making and isolating N-acetylcysteine amide, intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide; and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

Claim (Index 25):
The process of  claim 1 , wherein the batch size of NACA produced under GMP conditions is greater than 100 kg.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 97.0
- Lexical Diversity: 1.8
- Patent Class: 564.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15696912', '14632089', '15300092', '12707092', '13952028']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6699322789819919
- 35 USC 102 Novelty (BERT): 0.5437194444563229
- Combined Prediction Score: 0.6573109955294251
- Mean Citation Score: 186.20197
- Max Citation Score: 197.3479
- Similarity Product: 99.1064347602427

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test