PATENT CLAIM ANALYSIS

Application Number: 16370760
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["548", "541000"]

Abstract:
Provided herein are methods for the production of glycopyrronium tosylate and glycopyrronium tosylate compositions. Also provided herein are compositions useful in the production of glycopyrronium tosylate. Additionally provided herein are glycopyrronium tosylate compositions. Glycopyrronium tosylate is useful for the treatment of, among other conditions, hyperhidrosis.

Claim (Index 60):
A glycopyrronium tosylate composition produced by a method comprising:\n (i) contacting cyclopentylmandelic acid with 1-methylpyrrolidin-3-ol to form glycopyrrolate base: (ii) contacting the glycopyrrolate base with 5-nitroisophthalic acid to form glycopyrrolate base, 5-nitroisophthalate salt: (iii) contacting the glycopyrrolate base, 5-nitroisophthalate salt with an inorganic base to form glycopyrrolate base: (iv) contacting the glycopyrrolate base with methyl tosylate to produce glycopyrronium tosylate: wherein the glycopyrrolate base is contacted with a water-miscible organic solvent; and\n (v) purifying the glycopyrronium tosylate obtained in step (iv) by one or more crystallizations in an aqueous solvent to obtain a purified glycopyrronium tosylate; wherein the aqueous solvent consists essentially of water.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 99.0
- Lexical Diversity: 1.96154
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15895685', '14830638', '14473537', '15438636', '14643553']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7606048415425802
- 35 USC 102 Novelty (BERT): 0.6700536405117656
- Combined Prediction Score: 0.7515497214394987
- Mean Citation Score: 431.27782
- Max Citation Score: 629.99176
- Similarity Product: 620.1014635592127

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test