PATENT CLAIM ANALYSIS

Application Number: 16024283
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "649000"]

Abstract:
Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

Claim (Index 30):
A method for preparing an isolated compound according to  claim 29 , or pharmaceutically acceptable salt thereof, wherein the method comprises\n converting a D-amino acid to an N,N-dialkyl-D-aminoalcohol or converting an L-amino acid to an N,N-dialkyl-L-aminoalcohol; converting the dialkyl aminoalcohol to an activated intermediate comprising a halo group or a sulfonyl group; mixing the activated intermediate with a base and a diarylacetonitrile to provide a nitrile intermediate of formula (I), wherein Y is-CN; and exposing the nitrile intermediate to a Grignard reagent and an acid to form the compound of formula (I), wherein Y is \u2014C(O)R 14 .

Metadata:
- Claim Count in Document: 44.0
- Percentile: 94.0
- Lexical Diversity: 1.39474
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15245935', '14190702', '13759382', '12530214', '14465470']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7332771123416122
- 35 USC 102 Novelty (BERT): 0.6475179540722986
- Combined Prediction Score: 0.7247011965146809
- Mean Citation Score: 303.701184
- Max Citation Score: 774.36896
- Similarity Product: 559.3277560046769

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test