PATENT CLAIM ANALYSIS

Application Number: 16057867
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["548", "950000"]

Abstract:
The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

Claim (Index 13):
A method for producing coated silicone hydrogel contact lenses each having a crosslinked hydrophilic coating thereon, comprising the steps of:\n (a) obtaining a silicone hydrogel contact lens; (b) applying a prime coating of an anchoring polymer onto the silicone hydrogel contact lens, wherein the anchoring polymer is\n (i) an azetidinium-containing copolymer which comprises 1) first azetidinium-containing monomeric units, 2) monomeric units selected from the group consisting of first carboxyl-containing monomeric units, hydrophobic monomeric units, and combination thereof, and 3) optionally first amino-containing monomeric units,\n wherein the first azetidinium-containing monomeric units are derived from at least one first azetidinium-containing vinylic monomer of formula (1) or (2) \n \n in which:\n R\u2033 is hydrogen or methyl; \n T 7  and T 8  independent of each other are C 1  to C 14  alkyl group; \n Y 1 , Y 2 , and Y 3  independent of one other are a linkage selected from the group consisting of a direct bond, \u2014O\u2014, \u2014NR\u2032\u2014, \u2014C(O)\u2014NR\u2032\u2014, \u2014NR\u2032\u2014C(O)\u2014, \u2014O\u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014O\u2014, \u2014NR\u2032\u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014NR\u2032\u2014, \u2014C(O)\u2014O\u2014, \u2014O\u2014C(O)\u2014, \u2014NH\u2014C(O)\u2014NH\u2014Z 0 \u2014NH\u2014C(O)\u2014NH\u2014, \u2014O\u2014C(O)\u2014NH\u2014Z 0 \u2014NH\u2014C(O)\u2014O\u2014, \u2014O\u2014C(O)\u2014NH\u2014Z 0 \u2014NH\u2014C(O)\u2014NH\u2014, and \u2014NH\u2014C(O)\u2014NH\u2014Z 0 \u2014NH\u2014C(O)\u2014O\u2014; \n R\u2032 is hydrogen, a C 1 -C 20  unsubstituted or substituted, linear or branched alkyl group; \n Z 0  is a linear or branched C 2 -C 12  alkylene divalent radical or a C 5 -C 45  cycloaliphatic or aliphatic-cycloaliphatic divalent radical optionally containing therein one or more linkages of \u2014O\u2014, \u2014NR\u2032\u2014 and \u2014C(O)\u2014, R\u2032 is as defined above; \n Z 1 , Z 2 , and Z 3  independent of one other are a direct bond, a C 1 -C 20  unsubstituted or substituted, linear or branched alkylene divalent radical optionally containing therein one or more linkages of \u2014O\u2014, \u2014NR\u2032\u2014, and \u2014C(O)\u2014, a C 1 -C 7  alkyleneoxy C 1 -C 7  alkylene divalent radical, a divalent radical of \u2014(CH(R\u2033)CH 2 O) r1 \u2014CH(R\u2033)CH 2 \u2014 in which R\u2033 is as defined above and r1 is an integer of 1 to 20, an unsubstituted phenylene divalent radical, C 1 -C 4  alkyl or C 1 -C 4  alkoxy substituted phenylene divalent radical or C 7 -C 12  arakylene divalent radical, a C 5 -C 45  cycloaliphatic or aliphatic-cycloaliphatic divalent radical optionally containing therein one or more linkages of \u2014O\u2014, \u2014NR\u2032\u2014, and \u2014C(O)\u2014, a C 6 -C 24  aromatic or araliphatic divalent radical, or combinations thereof; \n p1, p2, and p3 independent of one another are zero or 1; \n Y 4  is a linkage selected from the group consisting of a direct bond, \u2014O\u2014, \u2014NR\u2032\u2014, \u2014C(O)\u2014NR\u2032\u2014, \u2014NR\u2032\u2014C(O)\u2014, \u2014O\u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014O\u2014, \u2014NR\u2032\u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014NR\u2032\u2014, \u2014C(O)\u2014O\u2014, \u2014O\u2014C(O)\u2014, R\u2032 is hydrogen, a C 1 -C 20  unsubstituted or substituted, linear or branched alkyl group; \n Z 4 , is a direct bond, a C 1 -C 20  unsubstituted or substituted, linear or branched alkylene divalent radical optionally containing therein one or more linkages of \u2014O\u2014, \u2014NR\u2032\u2014, and \u2014C(O)\u2014, a C 1 -C 7  alkyleneoxy C 1 -C 7  alkylene divalent radical, or a divalent radical of \u2014(CH(R\u2033)CH 2 O) r1 \u2014CH(R\u2033)CH 2 \u2014 in which R\u2033 is as defined above and r1 is an integer of 1 to 20; and \n Z 5  is a C 1 -C 20  unsubstituted or substituted, linear or branched alkyl group, \u2014(CH 2 ) r2 \u2014O\u2014(CH 2 CH 2 O) 1 \u2014Z 6  in which r1 is as defined above, r2 is zero or an integer of 1 to 7, and Z 6  is a C 1 -C 5  alkyl, \n wherein the first carboxyl-containing monomeric units are derived from at least one first carboxyl-containing vinylic monomer, wherein the hydrophobic monomeric units are derived from at least one hydrophobic vinylic monomer, wherein the first amino-containing monomeric units are derived from at least one first amino-containing vinylic monomer, and/or (ii) a homopolymer or copolymer of a carboxyl-containing vinylic monomer; and (c) heating the silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, thermally-crosslinkable hydrophilic polymeric material comprising reactive functional groups selected from the group consisting of azetidinium groups, carboxyl groups, amino groups, thiol groups, and combinations thereof, to and at a temperature from about 40\u00b0 C. to about 140\u00b0 C. for a period of time sufficient to induce intermolecular and intramolecular crosslinking reaction between one azetidinium group and one amino or carboxyl group, thereby forming a durable non-silicone hydrogel coating on the silicone hydrogel contact lens, provided that at least one of the anchoring polymer and the thermally-crosslinkable hydrophilic polymeric material comprises azetidinium groups.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.08696
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15216125', '13913734', '14962354', '13193651', '15633999']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7866619995259504
- 35 USC 102 Novelty (BERT): 0.5983534140826834
- Combined Prediction Score: 0.7678311409816236
- Mean Citation Score: 469.53208200000006
- Max Citation Score: 546.8089
- Similarity Product: 451.3646793275356

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test