PATENT CLAIM ANALYSIS

Application Number: 16211456
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["544", "315000"]

Abstract:
The present invention relates to N-(tetrazolylaryl) amide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Claim (Index 1):
A compound of general formula (I): in which A represents tetrazolyl which is attached to the rest of the molecule by the carbon atom; R 1  represents\n phenyl, \n C 3 -C 7 -cycloalkyl, \n 4- to 7-membered heterocycloalkyl containing 1 or 2 heteroatoms or heteroatom-containing groups selected from NH, \u2014NR 2 , N, O, S, SO and SO 2 , \n 5- to 7-membered lactam, \n 5- or 6-membered heteroaryl, wherein said 5-membered heteroaryl contains 1, 2 or 3 heteroatoms selected from the group consisting of S, N, NH, and O, and said 6-membered heteroaryl contains 1 or 2 N, or \n bicyclic 8- to 10-membered heteroaryl containing 1, 2 or 3 heteroatoms or heteratom-containing groups selected from the group consisting of N, NH, O, S, SO, and SO 2 ; \n wherein said R 1  is optionally substituted at one or more carbon atoms with 1 to 3 substituents R 1a  which are the same or different wherein R 1a  represents C 1 -C 5 -alkyl, C 3 -C 5 -cyclalkyl, \u2014(C 1 -C 3 -alkyl)\u2014(C 3 -C 5 -cyclalkyl), \u2014OC 1 \u2014C 5 -alkyl, \u2014OC 3 -C 5 -cycloalkyl, benzyl, NHR 2 , N(R 2 ) 2 , NH(C 3 -C 5 -cycloalkyl), halogen, CN, NHSO 2 R 2 , SO 2 R 2  or 4- to 7-membered heterocycloalkyl containing 1 or 2 heteroatoms or heteroatom-containing groups selected from NH, \u2014NR 2 , N, O, S, SO and SO 2 , and \n wherein independently, if R 1  represents 4- to 7-membered heterocycloalkyl, 5- to 7-membered lactam, 5-membered heteroaryl or bicyclic 8- to 10-membered heteroaryl, each ring nitrogen atom, if present, of said R 1  is optionally substituted with a substituent R 1b  wherein R 1b  represents C 1 -C 5 -alkyl, C 3 -C 5 -cycloalkyl, \u2014(C 1 -C 3 -alkyl)\u2014(C 3 -C 5 -cycloalkyl), benzyl, SO 2 R 2  or 4- to 7-membered heterocycloalkyl containing 1 or 2 heteroatoms or heteroatom-containing groups selected from NH, \u2014NR 2 , N, O, S, SO and SO 2 , and \n if R 1a  represents C 1 -C 5 -alkyl, C 3 -C 5 -cycloalkyl, \u2014(C 1 -C 3 -alkyl)\u2014(C 3 -C 5 -cycloalkyl), \u2014OC 1 -C 5 -alkyl or \u2014OC 3 \u2014C 5 -cycloalkyl and/or if R 1b  represents C 1 -C 5 -alkyl, C 3 -C 5 -cycloalkyl or \u2014(C 1 -C 3 -alkyl)\u2014(C 3 -C 5 -cycloalkyl), said C 1 -C 5 -alkyl, C 3 -C 5 -cycloalkyl, \u2014(C 1 -C 3 -alkyl)\u2014(C 3 -C 5 -cycloalkyl), \u2014OC 1 \u2014C 5 -alkyl and \u2014OC 3 \u2014C 5 -cycloalkyl independently are optionally substituted with one or more substituents independently selected from the group consisting of OH, OR 2  and F, and \n if R 1a  and/or R 1b  represent 4- to 7-membered heterocycloalkyl, each carbon atom of said 4- to 7-membered heterocycloalkyl is independently optionally substituted with one or more substituents independently selected from the group consisting of OH, OR 2  and F; \n R 2  represents C 1 -C 5 -alkyl optionally substituted with 1 to 5 fluorine atoms; X represents CR c  or N; R c  represents H, halogen, CN, OH, C 1 -C 5 -alkyl, or \u2014OC 1 \u2014C 5 -alkyl, wherein said C 1 -C 5 -alkyl and \u2014OC 1 \u2014C 5 -alkyl are optionally substituted with 1 to 5 fluorine atoms; R d  represents H, halogen, CN, OH, C 1 -C 5 -alkyl, or \u2014OC 1 \u2014C 5 -alkyl wherein said C 1 -C 5 -alkyl and \u2014OC 1 \u2014C 5 -alkyl are optionally substituted with 1 to 5 fluorine atoms; R e  represents H, halogen, or OH; R 3  and R 4  independently represent H or C 1 -C 3 -alkyl, wherein said C 1 -C 3 -alkyl is optionally substituted with 1 to 3 fluorine atoms; R 5  represents C 1 -C 5 -alkyl, (CH 2 ) p -phenyl, \u2014(CH 2 ) p -(C 5 -C 7 -cycloalkyl), 5- or 6-membered heteroaryl, wherein said 6-membered heteroaryl contains 1 or 2 nitrogen atoms, and wherein said 5-membered heteroaryl contains 1, 2, or 3 heteroatoms or heteroatom-containing groups, the heteroatoms being independently selected from the group consisting of S, N, NH and O, or bicyclic 8- to 10-membered heteroaryl containing 1, 2 or 3 heteroatoms or heteroatom-containing groups selected from NH, N, O, S, SO, and SO 2 ,\n wherein said R 5  is optionally substituted at one or more carbon atoms with 1 to 3 substituents which are the same or different and selected from the group consisting of C 1 -C 5 -alkyl, \u2014OC 1 \u2014C 5 -alkyl, halogen, OH and CN, wherein said C 1 -C 5 -alkyl and \u2014OC 1 \u2014C 5 -alkyl independently are optionally substituted with one or more substituents independently selected from the group consisting of OH, OR 2  and F, and \n wherein independently, if R 5  represents a 5-membered heteroaryl or bicyclic 8- to 10-membered heteroaryl, each ring nitrogen atom, if present, of said R 5  independently is optionally substituted with C 1 -C 5 -alkyl, which is optionally substituted with OH, OR 2  or 1 to 5 fluorine atoms; and \n p is 0 or 1; or an isomer, enantiomer, diastereomer, racemate, hydrate, solvate, or a salt thereof, or a mixture of the same.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 98.0
- Lexical Diversity: 1.45833
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15820429', '15534855', '16192314', '13739302', '14403903']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7951741715030581
- 35 USC 102 Novelty (BERT): 0.5235224153992617
- Combined Prediction Score: 0.7680089958926785
- Mean Citation Score: 313.93338000000006
- Max Citation Score: 331.09314
- Similarity Product: 249.4625132276309

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test