PATENT CLAIM ANALYSIS

Application Number: 15948716
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["424", "450000"]

Abstract:
Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag derivatized with a weak-base moiety that facilitates active loading of the drag through a LN transmembrane pH or ion gradient into the aqueous interior of the LN. The weak-base moiety can optionally comprise a lipophilic domain that facilitates active loading of the drag to the inner monolayer of the liposomal membrane. Advantageously, LN formulations of the drag derivatives exhibit improved solubility, reduced toxicity, enhanced efficacy, and/or other benefits relative to the corresponding free drags.

Claim (Index 42):
A pharmaceutical formulation comprising the liposome of  claim 31 .

Metadata:
- Claim Count in Document: 62.0
- Percentile: 91.0
- Lexical Diversity: 1.61194
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14302537', '13866873', '13467021', '12993482', '13866913']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8288882755781611
- 35 USC 102 Novelty (BERT): 0.6418083176724008
- Combined Prediction Score: 0.8101802797875851
- Mean Citation Score: 683.52984
- Max Citation Score: 799.9733
- Similarity Product: 547.5792275954246

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test