PATENT CLAIM ANALYSIS

Application Number: 15859805
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["435", "006100"]

Abstract:
The present disclosure provides systems, devices, and methods for purifying microorganism nucleic acid from a host sample, such as a whole blood sample from a human. In certain embodiments, devices and systems with multiple filters are employed and provide for the selective removal of blood cells and host nucleic acids from a sample in order to enrich for microorganism nucleic acid.

Claim (Index 1):
A method for purifying microorganism nucleic acid from a sample comprising:\n a) moving a biological sample through a system or device, wherein said biological sample comprises human cells and is suspected of containing microorganisms, and wherein said system or device comprises:\n i) a first size-exclusion filter that: excludes passage therethrough of lymphocytes, monocytes, neutrophils, eosinophils, and basophils, and allows passage therethrough of erythrocytes, lymphocytes, and platelets; \n ii) either:\n A) a second size-exclusion filter that: excludes passage therethrough of erythrocytes, lymphocytes, and platelets, and allows passage therethrough of microorganisms smaller than platelets; or \n B) both of the following:\n I) a second size-exclusion filter that excludes passage therethrough of erythrocytes and lymphocytes, but allows passage therethrough of platelets and microorganisms smaller than platelets, and \n II) a third size-exclusion filter that excludes passage therethrough of platelets, but allows passage therethrough of microorganisms smaller than platelets; and \n \n \n iii) a shearing filter that mechanically shears said microorganisms such that microorganism nucleic acid is released; and \n b) collecting a purified sample in or from said system or device, wherein said purified sample is free or at least 99% free of said human cells and comprises at least a portion of said microorganism nucleic acid if microorganisms are originally present in said sample.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 86.0
- Lexical Diversity: 1.55814
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13724527', '14237328', '12674403', '13046186', '13389139']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4740323315085676
- 35 USC 102 Novelty (BERT): 0.5621588774629808
- Combined Prediction Score: 0.4828449861040089
- Mean Citation Score: 209.675806
- Max Citation Score: 422.98712
- Similarity Product: 388.7546990336752

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test