PATENT CLAIM ANALYSIS

Application Number: 16133922
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["540", "546000"]

Abstract:
The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , Y 3 , and Y 4  are described herein.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt, thereof, wherein:\n X 1  is O; \n X 2  and X 4  are each CR 1 R 2 ; \n X 3  is CR 1\u2032 R 2\u2032 ; \n Y 1  and Y 4  are not bonded to \u2014C(O)NHOH and are each independently N or CR 1 ; \n Y 2  and Y 3  are each independently N or CR 1  when not bonded to \u2014C(O)NHOH and Y 2  and Y 3  are C when bonded to \u2014C(O)NHOH; \n wherein two of Y 1 , Y 2 , Y 3 , and Y 4  are N, and the other two are CR 1 ; \n L is selected from the group consisting of a bond, \u2014(CR 1 R 2 ) n \u2014, \u2014C(O)O\u2014, \u2014C(O)NR 3 \u2014, \u2014S(O) 2 \u2014, \u2014S(O) 2 NR 3 \u2014, \u2014S(O)\u2014, and \u2014S(O)NR 3 \u2014, wherein L is bound to the ring nitrogen through the carbonyl or sulfonyl group; \n R is selected from the group consisting of \u2014H, \u2014C 1 -C 6  alkyl, \u2014C 2 -C 6  alkenyl, \u2014C 4 -C 8  cycloalkenyl, \u2014C 2 -C 6  alkynyl, \u2014C 3 -C 8  cycloalkyl, \u2014C 5 -C 12  spirocycle, heterocyclyl, spiroheterocyclyl, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of \u2014OH, halogen, oxo, \u2014NO 2 , \u2014CN, \u2014R 1 , \u2014R 2 , \u2014OR 3 , \u2014NHR 3 , \u2014NR 3 R 4 , \u2014S(O) 2 NR 3 R 4 , \u2014S(O) 2 R 1 , \u2014C(O)R 1 , \u2014CO 2 R 1 , \u2014NR 3 S(O) 2 R 1 , \u2014S(O)R 1 , \u2014S(O)NR 3 R 4 , \u2014NR 3 S(O)R 1 , heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O; \n each R 1  and R 2  are independently, and at each occurrence, selected from the group consisting of \u2014H, \u2014R 3 , \u2014R 4 , \u2014C 1 -C 6  alkyl, \u2014C 2 -C 6  alkenyl, \u2014C 4 -C 8  cycloalkenyl, \u2014C 2 -C 6  alkynyl, \u2014C 3 -C 8  cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, \u2014OH, halogen, \u2014NO 2 , \u2014CN, \u2014NHC 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 N(C 1 -C 6  alkyl) 2 , \u2014N(C 1 -C 6  alkyl)S(O) 2 R 5 , \u2014S(O) 2 (C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6  alkyl, \u2014CO 2 C 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl)S(O) 2 C 1 -C 6  alkyl, or \u2014(CHR 5 ) n NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 5 , \u2014OR 3 , \u2014NHR 3 , \u2014NR 3 R 4 , \u2014S(O) 2 N(R 3 ) 2 , \u2014S(O) 2 R 5 , \u2014C(O)R 5 , \u2014CO 2 R 5 , \u2014NR 3 S(O) 2 R 5 , \u2014S(O)R 5 , \u2014S(O)NR 3 R 4 , \u2014NR 3 S(O)R 5 , heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O; \n R 1\u2032  and R 2\u2032  are independently, and at each occurrence, selected from the group consisting of H, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each aryl or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 3 , \u2014R 5 , \u2014OR 3 , \u2014NHR 3 , \u2014NR 3 R 4 , \u2014S(O) 2 N(R 3 ) 2 , \u2014S(O) 2 R 5 , \u2014C(O)R 5 , \u2014CO 2 R 5 , \u2014NR 3 S(O) 2 R 5 , \u2014S(O)R 5 , \u2014S(O)NR 3 R 4 , \u2014NR 3 S(O)R 5 , heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein at least one of R 1\u2032  or R 2\u2032  is not H; \n R 3  and R 4  are independently, and at each occurrence, selected from the group consisting of \u2014H, \u2014C 1 -C 6  alkyl, \u2014C 2 -C 6  alkenyl, \u2014C 4 -C 8  cycloalkenyl, \u2014C 2 -C 6  alkynyl, \u2014C 3 -C 8  cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, \u2014S(O) 2 N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 (C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6  alkyl, \u2014CO 2 C 1 -C 6  alkyl, and \u2014(CHR 5 ) n N(C 1 -C 6  alkyl) 2 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 5 , \u2014O(C 1 -C 6 ) alkyl, \u2014NH(C 1 -C 6 ) alkyl, \u2014N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 NHC 1 -C 6  alkyl, \u2014C(O)C 1 -C 6  alkyl, \u2014CO 2 C 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl)S(O) 2 C 1 -C 6  alkyl, \u2014S(O)R 5 , \u2014S(O)N(C 1 -C 6  alkyl) 2 , \u2014N(C 1 -C 6  alkyl)S(O)R 5 , heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O; \n or R 3  and R can combine with the nitrogen atom to which they are attached to form a heterocycle or heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each heterocycle or heteroaryl is optionally substituted with \u2014R 4 , \u2014OR 4 , or \u2014NR 4 R 5 ; \n R 5  is independently, and at each occurrence, selected from the group consisting of \u2014H, \u2014C 1 -C 6  alkyl, \u2014C 2 -C 6  alkenyl, \u2014C 4 -C 8  cycloalkenyl, \u2014C 2 -C 6  alkynyl, \u2014C 3 -C 8  cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, \u2014OH, halogen, \u2014NO 2 , \u2014CN, \u2014NHC 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 NH(C 1 -C 6  alkyl), \u2014S(O) 2 N(C 1 -C 6  alkyl) 2 , \u2014S(O) 2 C 1 -C 6  alkyl, \u2014C(O)C 1 -C 6  alkyl, \u2014CO 2 C 1 -C 6  alkyl, \u2014N(C 1 -C 6  alkyl)SO 2 C 1 -C 6  alkyl, \u2014S(O)(C 1 -C 6  alkyl), \u2014S(O)N(C 1 -C 6  alkyl) 2 , \u2014N(C 1 -C 6  alkyl)S(O)(C 1 -C 6  alkyl) and \u2014(CH 2 ) n N(C 1 -C 6  alkyl) 2 ; and \n each n is independently and at each occurrence an integer from 0 to 6.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 97.0
- Lexical Diversity: 1.46512
- Patent Class: 540.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16133918', '15013826', '15013820', '15013816', '15013814']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7779363166605965
- 35 USC 102 Novelty (BERT): 0.5671693368103108
- Combined Prediction Score: 0.7568596186755678
- Mean Citation Score: 421.882506
- Max Citation Score: 436.43002
- Similarity Product: 422.314030515635

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test