PATENT CLAIM ANALYSIS

Application Number: 16216666
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["800", "006000"]

Abstract:
The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

Claim (Index 7):
A mouse cell whose genome comprises human VH, D and JH gene segments upstream of a constant region at an endogenous heavy chain locus and human VL and JL gene segments upstream of an constant gene segment at an endogenous light chain locus, wherein the gene segments are operably linked to a constant gene segment thereof so that the cell is capable of expressing immunoglobulin heavy and light chains comprising human VH and VL domains respectively, wherein the heavy chain locus comprises a human 01 allele VH gene segment capable of recombining with a human D and a human JH gene segment to produce a human VH domain, wherein the light chain locus comprises a human 01 allele VL gene segment capable of recombining with a human JL gene segment to produce a human VL domain;\n wherein at least one of said one or more human VH gene segments is selected from the group consisting of VH3-23*04, VH7-4-1*01, VH4-4*02, VH 1-3*01, VH3-13*01, VH3-7*01, VH3-20*d01 and VH3-9*01 and/or wherein at least one of said one or more human VK gene segments is selected from the group consisting of VK4-1*01, VK2-28*01, VK1D-13*d01, VK1-12*01, VK1 D-12*02, VK3-20*01, VK1-17*01, VK1 D-39*01, VK3-1 1*01, VK1 D-16*01 and VK1-9*d01.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 98.0
- Lexical Diversity: 1.61111
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15088805', '13846672', '15690183', '14935010', '13434361']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6910927930718358
- 35 USC 102 Novelty (BERT): 0.7397366893044429
- Combined Prediction Score: 0.6959571826950965
- Mean Citation Score: 877.5522199999997
- Max Citation Score: 1065.068
- Similarity Product: 855.3192798933983

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test