PATENT CLAIM ANALYSIS

Application Number: 15873293
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "255050"]

Abstract:
Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

Claim (Index 1):
A compound having formula (I): including enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein: A is selected from the group consisting of W is selected from the group consisting of hydrogen, halogen, C 1-6  alkyl, C 3-7  branched alkyl, C 3-7  cycloalkyl, C 1-6  haloalkyl, and Z; X is selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, C 3-7  branched alkyl, OR 4 , and the C 2-6  sugar alcohols ethylene glycol, glycerol, erythritol, threitol, arabitol, xylitol, ribitol, mannitol, galacitol frucitol, iditol, inositol, and sorbitol; q is 0, 1, 2, 3, 4, 5, 6;\n Y is selected from the group consisting of hydrogen, \n Z at each occurrence is independently selected from the group consisting of X 1  and X 2  are at each occurrence independently selected from the group consisting of S, SO, and SO 2 ; n is 0, 1, 2, 3, 4 R is selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, C 3-7  cycloalkyl; R 1  is at each occurrence independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, C 3-7  cycloalkyl, C 1-6  alkoxy, C 3-7  branched alkoxy, C 1-6  haloalkyl, halogen, and CN; R 2  is at each occurrence independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, C 3-7  cycloalkyl, C 1-6  alkoxy, C 3-7  branched alkoxy, C 1-6  haloalkyl, halogen, CN, and Z;\n R 3  is at each occurrence independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, C 3-7  cycloalkyl, C 1-6  alkoxy, C 3-7  branched alkoxy, C 1-6  haloalkyl, halogen, CN, \n and Z;\n R 4  selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, C 3-7  branched alkyl, and C 3-7  cycloalkyl; \n R 5  is at each occurrence independently selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 1-6  alkoxy, and hydroxy; \n two R 5  substituents can be joined together with the atoms to which they are bound to form a 5 to 6 membered ring; \n R 6  is at each occurrence independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, C 3-7  cycloalkyl, C 1-6  alkoxy, C 3-7  branched alkoxy, C 1-6  haloalkyl, halogen, CN, \n NR 12a R 12b , and Z;\n R 7  is at each occurrence independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, C 3-7  cycloalkyl, C 1-6  alkoxy, C 3-7  branched alkoxy, C 1-6  haloalkyl, halogen, CN, \n NR 12a R 12b , and Z;\n R 7a  is at each occurrence independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, aryl, and benzyl; \n R 8  is at each occurrence independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, C 3-7  cycloalkyl, C 1-6  alkoxy, C 3-7  branched alkoxy, C 1-6  haloalkyl, halogen, and CN; \n R 9  is at each occurrence independently selected from the group consisting of C 1-6  alkyl, C 3-7  branched alkyl, and C 3-7  cycloalkyl; \n R 10  is at each occurrence independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, and C 3-7  cycloalkyl; \n R 11a  and R 11b  are at each occurrence independently selected from the group consisting hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, and C 3-7  cycloalkyl; \n R 12a  and R 12b  are at each occurrence independently selected from the group consisting hydrogen, C 1-6  alkyl, C 3-7  branched alkyl, and C 3-7  cycloalkyl.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 86.0
- Lexical Diversity: 1.15385
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15873255', '14913508', '16067444', '11048657', '14382074']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8008764324255747
- 35 USC 102 Novelty (BERT): 0.5371692380094483
- Combined Prediction Score: 0.7745057129839621
- Mean Citation Score: 330.21107600000005
- Max Citation Score: 363.78082
- Similarity Product: 297.98794748357886

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test