PATENT CLAIM ANALYSIS

Application Number: 15888736
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "235200"]

Abstract:
Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

Claim (Index 1):
A method for treating pathological calcification or vascular calcification comprising administering a compound of Formula I, or a pharmaceutically acceptable salt, polymorph, solvate, tautomer, metabolite, or N-oxide thereof: wherein:\n Y 1  and Y 2  are independently a bond or \u2014N(R 6 )\u2014, wherein at least one of Y 1  and Y 2  is \u2014N(R 6 )\u2014; \n L 1  and L 2  are independently a bond or optionally substituted alkylene; \n X 1  is \u2550N\u2014 or \u2550C(R 2 )\u2014; \n X 2  is \u2550N\u2014 or \u2550C(R 3 )\u2014; \n R 1  and R 4  are independently selected from the group consisting of hydrogen, halogen, \u2014CN, \u2014C(O)\u2014N(R 7 )\u2014R 8 , \u2014C(O)\u2014O\u2014R 9 , optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkoxy, haloalkyl, haloalkoxy, optionally substituted phenyl, and optionally substituted 5- or 6-membered heteroaryl; \n R 2 , R 3 , and R 5  are independently selected from the group consisting of hydrogen, halogen, \u2014CN, \u2014C(O)\u2014N(R 7 )\u2014R 8 , \u2014C(O)\u2014O\u2014R 9 , optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkoxy, haloalkyl, haloalkoxy, optionally substituted phenyl, and optionally substituted 5- or 6-membered heteroaryl; \n R 6  is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, or optionally substituted alkynyl; \n R 7  and R 8  are independently hydrogen, optionally substituted alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, or optionally substituted phenyl, \n or R 7  and R 8  together with the nitrogen atom to which they are attached form an optionally substituted heterocycloamino; \n R 9  is selected from the group consisting of hydrogen, optionally substituted alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, and optionally substituted phenyl; and \n A is selected from the group consisting of \u2014C(O)\u2014N(R 7 )\u2014R 8 , \u2014C(O)\u2014O\u2014R 9 , optionally substituted phenyl, and optionally substituted 5- or 6-membered heteroaryl.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 88.0
- Lexical Diversity: 1.64
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14379475', '15546165', '12291756', '15319329', '15799771']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8052651322253348
- 35 USC 102 Novelty (BERT): 0.5713117906572414
- Combined Prediction Score: 0.7818697980685255
- Mean Citation Score: 425.3989360000001
- Max Citation Score: 484.9471
- Similarity Product: 388.3249828820228

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test