PATENT CLAIM ANALYSIS

Application Number: 16228835
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["514", "253120"]

Abstract:
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK 1 ) receptor. The compounds have the general formula (I):

Claim (Index 1):
A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein: R is selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, amino, alkyl, alkenyl, cycloalkyl, halogen, alkoxyalkyl, \u2014OR 101 , \u2014NR 101 R 102 , \u2014NR 101 C(O)R 102 , \u2014C(O)R 101 , \u2014C(O)OR 101 , \u2014C(O)NR 101 R 102 , -alkylNR 101 R 102 , \u2014S(O) 2 R 102 , \u2014SR 101 , \u2014S(O) 2 NR 101 R 102 , aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl and heteroarylalkyl, each optionally independently substituted with one or more independent R 103  substituents; R 1  and R 2  are independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, amino, alkyl, alkenyl, cycloalkyl, halogen, alkoxyalkyl, \u2014OR 101 , \u2014NR 101 R 102 , \u2014NR 101 C(O)R 102 , \u2014C(O)R 101 , \u2014C(O)OR 101 , \u2014C(O)NR 101 R 102 , -alkylNR 101 R 102 , \u2014S(O) 2 R 102 , \u2014SR 101 , \u2014S(O) 2 NR 101 R 102 , aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl and heteroarylalkyl, each optionally independently substituted with one or more independent R 103  substituents; or R 1  together with the atoms and/or other substituent(s) on the same phenyl ring, form a fused or non-fused mono, bicyclic or tricyclic heterocyclic or carbocyclic ring which is optionally independently substituted with one or more R 103  substituents; or R 2  together with the atoms and/or other substituent(s) on the same phenyl ring, form a fused or non-fused mono, bicyclic or tricyclic heterocyclic or carbocyclic ring which is optionally independently substituted with one or more R 103  substituents; R 3  and R 4  are independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, amino, alkyl, alkenyl, cycloalkyl, halogen, alkoxyalkyl, \u2014OR 101 , \u2014NR 101 R 102 , \u2014NR 101 C(O)R 102 , \u2014C(O)R 101 , \u2014C(O)OR 101 , \u2014C(O)NR 101 R 102 , -alkylNR 101 R 102 , \u2014S(O) 2 R 102 , \u2014SR 101 , \u2014S(O) 2 NR 101 R 102 , aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl and heteroarylalkyl, each optionally independently substituted with one or more independent R 103  substituents; or R 3  and R 4 , together with the atoms connecting the same, form a fused or non-fused mono, bicyclic or tricyclic heterocyclic or carbocyclic ring which is optionally independently substituted with one or more R 103  substituents; R 5  and R 6  are independently selected from the group consisting of hydrogen, hydroxy, hydroxyalkyl, amino, alkyl, alkenyl, cycloalkyl, halogen, alkoxyalkyl, \u2014OR 101 , \u2014NR 101 R 102 , \u2014NR 101 C(O)R 102 , \u2014C(O)R 101 , \u2014C(O)OR 101 , \u2014C(O)NR 101 R 102 , -alkylNR 101 R 102 , \u2014S(O) 2 R 102 , \u2014SR 101 , \u2014S(O) 2 NR 101 R 102 , aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl and heteroarylalkyl, each optionally independently substituted with one or more independent R 103  substituents; X is selected from the group consisting of \u2014C(O)NR 101 R 102 , -alkylO, -alkylNR 101 R 102 , \u2014NR 101 C(O) and \u2014NR 101 alkyl, each optionally independently substituted with one or more independent R 103  substituents; Y is selected from the group consisting of \u2014NR 101 R 102 , \u2014NR 101 alkylOH, \u2014NR 101 S(O) 2 alkyl, \u2014NR 101 S(O) 2 phenyl, \u2014N\u2550CH\u2014NR 101 R 102 , heterocycloalkyl and heterocycloalkylalkyl, each optionally independently substituted with one or more independent R 103  substituents; Z is a structural formula selected from the group consisting of where formula (Ia) refers to an oxide; R 100 , R 100\u2033 , R 101 , R 102  and R 103  are each independently selected from the group consisting of hydrogen, cyano, \u2014NO 2 , \u2014OR 104 , oxide, hydroxy, amino, alkyl, alkenyl, cycloalkyl, halogen, alkoxy, alkoxyalkyl, aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, heteroarylalkyl, \u2014C(O)R 104 , \u2014C(O)OR 104 , \u2014C(O)NR 104 R 105 , \u2014NR 104 R 105 , \u2014NR 104 S(O) 2 R 105 , \u2014NR 104 C(O)R 105 , \u2014S(O) 2 R 104 , \u2014SR 104  and \u2014S(O) 2 NR 104 R 105 , each optionally independently substituted with one or more independent R 103  substituents; or R 101 , R 102 , together with the atoms connecting the same, form a fused or non-fused mono, bicyclic or tricyclic heterocyclic or carbocyclic ring which is optionally independently substituted with one or more R 103  substituents; or R 100 , R 100\u2033 , together with the atoms connecting the same, form a fused or non-fused mono, bicyclic or tricyclic heterocyclic or carbocyclic ring which is optionally independently substituted with one or more R 103  substituents; R 104  and R 105  are each independently selected from the group consisting of hydrogen, cyano, \u2014NO 2 , hydroxy, oxide, hydroxyalkyl, amino, alkyl, alkenyl, cycloalkyl, halogen, alkoxy, alkoxyalkyl, aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl and heteroarylalkyl; m is 0, 1, 2, 3, or 4; n is 0, 1, 2, 3, 4 or 5; p is 0 or 1; and with a proviso that if a non-pyridine N-Oxide (N \u2212 \u2192O + ) is present on the compound of Formula (I), then the total number of N-Oxide on the compound of Formula (I) is more than one.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 98.0
- Lexical Diversity: 1.19355
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15194984', '15874325', '14360991', '12637719', '11582293']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8269308312691632
- 35 USC 102 Novelty (BERT): 0.5399142283945112
- Combined Prediction Score: 0.7982291709816981
- Mean Citation Score: 329.305366
- Max Citation Score: 397.34216
- Similarity Product: 288.02367182107923

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test