PATENT CLAIM ANALYSIS

Application Number: 15773620
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-02
Patent Classification: ["552", "553000"]

Abstract:
The present application relates to a method of preparing a bile acid derivative, or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, comprising direct alkylation at the C-6 position of KLCA.

Claim (Index 20):
A method of preparing obeticholic acid (OCA): or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, comprising protecting the hydroxyl group at the C-3 position of KLCA to form Compound 1: wherein PG is a protecting group,\n alkylating the carbon atom at the C-6 position of Compound 1 with an alkylating agent to form Compound 2: \n and\n reducing the keto group at the C-7 position of Compound 2 to form OCA:

Metadata:
- Claim Count in Document: 122.0
- Percentile: 93.0
- Lexical Diversity: 1.26667
- Patent Class: 552.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16094535', '15750683', '15748716', '15139138', '14120366']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6184607803271328
- 35 USC 102 Novelty (BERT): 0.6131548293272093
- Combined Prediction Score: 0.6179301852271405
- Mean Citation Score: 301.663086
- Max Citation Score: 364.41077
- Similarity Product: 254.30116297675312

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test