PATENT CLAIM ANALYSIS

Application Number: 16101327
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["435", "455000"]

Abstract:
Provided herein is chitosan-derivative nanoparticle comprising chitosan functionalized with a cationic amino acid and a hydrophilic polyol; and methods of making and using same, e.g., for gene delivery in vivo.

Claim (Index 7):
The chitosan-derivative nanoparticle of any of the preceding claims, comprising chitosan-nucleic acid polyplexes comprising chitosan molecules having an average molecular weight of less than 65 kDa before functionalization, on average less than 400 glucosamine monomer units, an N/P ratio of 2 to 20, an average hydrodynamic diameter of less than 500 nm, an average zeta potential of at least 0 mV at an acidic pH, a PDI of less than 0.5, and a nucleic acid concentration greater than 0.5 mg/ml, wherein said chitosan-nucleic acid polyplexes are substantially free of precipitated polyplex, and said chitosan-nucleic acid polyplexes are size stable in that they increase in average diameter by less than 100% at room temperature for at least 6 hours, at least 12 hours, at least 24 hours, or at least 48 hours.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 96.0
- Lexical Diversity: 1.13333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15025218', '14386321', '15489199', '14266584', '15849595']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.623735163760736
- 35 USC 102 Novelty (BERT): 0.6561433712966269
- Combined Prediction Score: 0.6269759845143251
- Mean Citation Score: 469.82383800000014
- Max Citation Score: 691.9571
- Similarity Product: 592.9746886774003

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test