PATENT CLAIM ANALYSIS

Application Number: 15757192
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "04400A"]

Abstract:
Compositions and methods for treating hypertension in a subject are provided, including administering an antisense oligomer effective to reduce expression of cytochrome P450 3A5 (CYP3A5) enzyme. The antisense oligomer includes phosphorodiamidate morpholino oligonucleotide (PMO), phosphorothioate 2′-O-methyl oligoribonucleotides (PSO), locked nucleic acid nucleotide, locked nucleic acid analog nucleotide, or another modified oligonucleotide backbone or nuclease-resistant backbone. The antisense oligomer is administered transdermally, subcutaneously, or orally, and optionally with a pharmaceutically acceptable carrier. In one embodiment, the antisense oligomer is an oligomer that is antisense to mRNAs that encode CYP3A5, for instance targeted at the AUG start site of the mRNAs that encode CYP3A5 or at a G4 structure within CYP3A5.

Claim (Index 8):
A composition, comprising:\n an antisense oligomer comprising the sequence of SEQ ID NO: 1 or overlapping the sequence of SEQ ID NO: 1 with a free energy between \u221225 and \u221235 kilocalories per mole (kcal/mol); or an antisense oligomer comprising the sequence of SEQ ID NO: 4 or overlapping the sequence of SEQ ID NO: 4 with a free energy between \u221225 and \u221235 kilocalories per mole (kcal/mol); or an antisense oligomer comprising the sequence of SEQ ID NO: 5 or overlapping the sequence of SEQ ID NO: 5 with a free energy between \u221225 and \u221235 kilocalories per mole (kcal/mol); or an antisense oligomer comprising the sequence of SEQ ID NO: 6 or overlapping the sequence of SEQ ID NO: 6 with a free energy between \u221225 and \u221235 kilocalories per mole (kcal/mol); or an antisense oligomer comprising the sequence of SEQ ID NO: 7 or overlapping the sequence of SEQ ID NO: 7 with a free energy between \u221225 and \u221235 kilocalories per mole (kcal/mol).

Metadata:
- Claim Count in Document: 13.0
- Percentile: 90.0
- Lexical Diversity: 1.69737
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15573184', '09974619', '12267437', '14581485', '13219401']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7347340134283075
- 35 USC 102 Novelty (BERT): 0.5276904738759217
- Combined Prediction Score: 0.7140296594730688
- Mean Citation Score: 288.630494
- Max Citation Score: 320.2454
- Similarity Product: 221.393634907198

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test