PATENT CLAIM ANALYSIS

Application Number: 15907470
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["435", "440000"]

Abstract:
The present invention relates to an improved method for cell line development which is generally applicable to production of any therapeutic protein that can be produced using mammalian Cell lines and in particular Chinese Hamster Ovary (CHO) cells. The method combines site directed integration (SDI), expression construct components improving the post-transcriptional processing of the gene of interest (GOI), novel design of the GOI genome target location and the introduction of a onetime pre-CLD host cell line selection workflow to generate a production competent cell line that can then be used in multiple CLD efforts from that point on.

Claim (Index 2):
Method according to  claim 1 , wherein said candidate cells or cell populations are generated according to any of the following procedures:\n (a) isolating clones from a culture of said recombinant cell or cell population or descendants thereof; or (b) isolating pools or clones after (i) different culture time in a continuous culture format such as a chemostat or (ii) different number of individual cultures starting with inoculation of a first culture using said recombinant cell or cell population or descendants thereof and using a volume from a finished culture to inoculate a next culture or (iii) a combination of (i) and (ii); or (c) performing targeted engineering by applying gene editing methods to introduce, remove or modify genetic material in the genome of said recombinant cell or cell population or descendants thereof; or (d) using an isolated and expanded clone from a culture of said recombinant cell or cell population or descendants thereof to inoculate a culture in procedure (b) or (e) any combination of procedure (a) to (d).

Metadata:
- Claim Count in Document: 24.0
- Percentile: 88.0
- Lexical Diversity: 1.38462
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14967689', '14092786', '13752647', '12793898', '12507252']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6133676970002594
- 35 USC 102 Novelty (BERT): 0.5251916963277166
- Combined Prediction Score: 0.6045500969330052
- Mean Citation Score: 308.898376
- Max Citation Score: 313.97794
- Similarity Product: 210.7062227386617

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test