PATENT CLAIM ANALYSIS

Application Number: 16011263
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["424", "009100"]

Abstract:
A fusion molecule is provided that includes one or more inhibitory nucleic acids, a targeting polypeptide, and a nucleic acid binding moiety. The targeting polypeptide and the nucleic acid binding moiety include specific the amino acid sequences. A fusion molecule is also provided that includes one or more inhibitory nucleic acids, a targeting polypeptide, and a nucleic acid binding moiety adapted to bind a double-stranded RNA or to a small hairpin RNA. The targeting polypeptide being CCL27 or CCL11 or a fragment thereof.

Claim (Index 2):
A fusion molecule comprising one or more inhibitory nucleic acids, a targeting polypeptide, and a nucleic acid binding moiety adapted to bind a double-stranded RNA or to a small hairpin RNA, wherein said targeting polypeptide consists of CCL27 or CCL11 or a fragment thereof having like targeting, and said nucleic acid binding moiety is selected from the group consisting of: histone, protamine, cysteine-less human protamine 1 fused with the heavy chain of human ferritin, RDE4 and PKR (Accession number in parenthesis) (AAA36409, AAA61926, Q03963), TRBP (P97473, AAA36765), PACT (AAC25672, AAA49947, NP_609646), Staufen (AAD17531, AAF98119, AAD17529, P25159), NFAR1 (AF167569), NFAR2 (AF167570, AAF31446, AAC71052, AAA19960, AAA19961, AAG22859), SPNR (AAK20832, AAF59924, A57284), RHA (CAA71668, AAC05725, AAF57297), NREBP (AAK07692, AAF23120, AAF54409, T33856), kanadaptin (AAK29177, AAB88191, AAF55582, NP_499172, NP_198700, BAB19354), HYL1 (NP_563850), hyponastic leaves (CAC05659, BAB00641), ADAR1 (AAB97118, P55266, AAK16102, AAB51687, AF051275), ADAR2 P78563, P51400, AAK17102, AAF63702), ADAR3 (AAF78094, AAB41862, AAF76894), TENR (XP_059592, CAA59168), RNaseIII (AAF80558, AAF59169, Z81070Q02555/S55784, P05797), and Dicer (BAA78691, AF408401, AAF56056, 544849, AAF03534, Q9884), RDE-4 (AY071926), F1120399 (NP_060273, BAB26260), CG1434 (AAF48360, EAA12065, CAA21662), CG13139 (XP_059208, XP_143416, XP_110450, AAF52926, EEA14824), DGCRK6 (BAB83032, XP_110167) CG1800 (AAF57175, EAA08039), F1120036 (AAH22270, XP_134159), MRP-L45 (BAB14234, XP_129893), CG2109 (AAF52025), CG12493 (NP_647927), CG10630 (AAF50777), CG17686 (AAD50502), T22A3.5 (CAB03384) and nameless Accession number EAA14308.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 94.0
- Lexical Diversity: 2.21951
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14220726', '12988148', '15138604', '15435233', '15036298']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4392582205405174
- 35 USC 102 Novelty (BERT): 0.55138136904925
- Combined Prediction Score: 0.4504705353913907
- Mean Citation Score: 345.17072399999995
- Max Citation Score: 414.60916
- Similarity Product: 309.633360296545

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test