PATENT CLAIM ANALYSIS

Application Number: 15759723
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "085200"]

Abstract:
This disclosure describes an adaptive NK cell, an isolated population of adaptive Natural Killer (NK) cells, a composition including an adaptive NK cell, and methods for producing, preparing, and using an adaptive NK cell or an isolated population or composition including an adaptive NK cell. The adaptive NK cells may be used to treat a viral infection or a tumor.

Claim (Index 53):
A composition comprising an enriched or isolated population of adaptive NK cells obtained by the method of  claim 49 , wherein the adaptive NK cells\n (i) are CD56 dim , and one or more of NKG2C + , CD57 + , and TIGIT low ; (ii) are CD3 \u2212 , CD56 +  and at least one of CD57 + , NKG2C + , SYK \u2212 , Fc\u03b5R\u03b3 \u2212 , EAT-2 \u2212 , CD56 dim , TIGIT low , CD45RO + , and CD45RA \u2212 ; (iii) exhibit reduced expression of at least one of PLZF and PD-1 compared to a canonical NK cell; (iv) are CD56 dim  and NKG2C + ; (v) exhibit an enhanced anti-tumor immune activity compared to a canonical NK cell; (vi) can overcome myeloid-derived suppressor cell (MDSC)-induced suppression of an immune response; (vii) can overcome Treg-induced suppression of an immune response; or (viii) are long-lived compared to a canonical NK cell.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.91667
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12855203', '13865762', '13946266', '14547084', '15167166']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6731883996841245
- 35 USC 102 Novelty (BERT): 0.5349498165218458
- Combined Prediction Score: 0.6593645413678966
- Mean Citation Score: 332.60156
- Max Citation Score: 374.96857
- Similarity Product: 255.7075488905293

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test