PATENT CLAIM ANALYSIS

Application Number: 15756021
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "034000"]

Abstract:
The present invention relates to a preparation method for modified sodium alginate embolization microspheres and a method for carrying an anti-cancer drug doxorubicin by means of modified sodium alginate embolization microspheres. The preparation method includes the following steps: (1) sodium alginate is modified by using taurine, so that modified sodium alginate is synthesized; (2) with high-concentration aqueous modified sodium alginate solution as a water phase, mineral oil as an oil phase and polyaldehyde cellulose as a crosslinking agent, modified sodium alginate embolization microspheres are prepared by an inverse emulsification method. By modifying sodium alginate by means of taurine, on one hand, sulfonic acid groups are introduced into the embolization microspheres, so that the drug-carrying rate is increased; on the other hand, the viscosity of a sodium alginate solution is decreased, which is favorable for the preparation of the high-concentration sodium alginate solution, and thereby regular sodium alginate embolization microspheres can be obtained.

Claim (Index 1):
A method for preparing modified sodium alginate embolization microspheres, comprising the following steps:\n (1) subjecting taurine and sodium alginate to an amidation reaction, and obtaining a modified sodium alginate product, and wherein adopted catalysts are 1-ethyl-3-(3-dimethylaminopropyl) carbodiiehydrochlide and N-hydroxysuccinimide, and a reaction is carried out in a phosphate buffer solution with a pH of 6.0; (2) precipitating the modified sodium alginate product by using isopropanol, re-dissolving the modified sodium alginate product by deionized water, freeze drying the modified sodium alginate product after purification, and re-dissolving the modified sodium alginate product, and obtaining an aqueous solution of modified sodium alginate; (3) dispersing high-concentration of the aqueous solution of modified sodium alginate into mineral oil for emulsification by adopting an inverse crosslinking-emulsion method, adding polyaldehyde cellulose as a crosslinking agent, and obtaining modified sodium alginate embolization microspheres.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 2.11111
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13809361', '15064317', '11784066', '12089797', '11430789']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.691769955957894
- 35 USC 102 Novelty (BERT): 0.4937810174497725
- Combined Prediction Score: 0.6719710621070819
- Mean Citation Score: 185.595164
- Max Citation Score: 212.1728
- Similarity Product: 156.47100546875

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test