PATENT CLAIM ANALYSIS

Application Number: 15987321
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "093700"]

Abstract:
Methods and compositions for producing mature myotubes are provided herein. In some instances, the method involves contacting a myoblast in an in vitro culture with a compound, wherein the contacting the myoblast in the in vitro culture with the compound results in generation of mature myotubes or myotube-like cells. In some cases, methods of treatment are provided involving treating a subject with a compound such as a Chk1 inhibitor in order to treat muscle deficiency. The compound may be administered as a stand-alone therapy or in combination with a cell therapy, such as introduction of muscle precursor cells such as satellite cells or myoblasts. Methods for identifying compounds that induce formation of mature myotubes or myotube-like cells from myoblasts are also provided herein, as well as methods of using the identified compounds to treat subjects.

Claim (Index 12):
The method of  claim 1 , wherein the mature myotubes exhibiting the two or more features make up at least 50% of a culture in the absence of purification or selection for mature myotubes.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 93.0
- Lexical Diversity: 2.01389
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13653021', '14401612', '13523337', '12340933', '14277969']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7105007457045228
- 35 USC 102 Novelty (BERT): 0.5359065982301869
- Combined Prediction Score: 0.6930413309570892
- Mean Citation Score: 299.565084
- Max Citation Score: 314.81412
- Similarity Product: 160.60068306401251

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test