PATENT CLAIM ANALYSIS

Application Number: 16002363
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "064000"]

Abstract:
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Claim (Index 1):
A compound of Formula (Ia) or (Ib) or pharmaceutically acceptable salts, isomers, stereoisomers, dimers, trimers, tautomers, or N-oxides thereof: wherein:\n M is hydrogen, fluoro, chloro, bromo, \u2014CF 3 , \u2014CN, \u2014OR 4 , \u2014SR 4 , \u2014S(\u2550O)R 4 , \u2014S(\u2550O) 2 R 4 , \u2014S(\u2550O) 2 N(R 4 R 5 ), \u2014N(R 4 R 5 ), \u2014N(R 4 )C(\u2550O)R 4 , \u2014N(R 4 )C(\u2550O)N(R 4 R 5 ), \u2014N(R 4 )S(\u2550O) 2 R 4 , \u2014N(R 4 )Heteroaryl, \u2014C(\u2550O)R 4 , \u2014C(\u2550O)N(R 4 R 5 ), \u2014C(\u2550O)(C 1 -C 3 alkylene)C(\u2550O)R 4 , optionally substituted oxyimino, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl; \n each R 1  and R 2  are independently hydrogen, fluoro, chloro, bromo, optionally substituted C 1 -C 6  alkyl, optionally substituted aryl, \u2014OR 4 , \u2014SR 4 , or \u2014N(R 4 R 5 ); or \n R 1  and R 2  are taken together with the carbon to which they are attached to form an optionally substituted cycloalkyl; or \n when n is at least 2, two R 1  on adjacent carbons are taken together to form a double bond; or two R 1  and two R 2  on adjacent carbons are taken together to form a triple bond; \n provided that M is \u2014CF 3  or at least one of R 1  or R 2  is fluoro; \n n is 0, 1, 2, 3, 4, 5, or 6; \n X 1  and X 2  are independently \u2014OR 4 , or F; when present; \n Z is >C(\u2550O), >C(\u2550S), or >S(\u2550O) 2 ; \n R 3  is R 31 , \u2014(R 30 ) q OR 31 , \u2014(R 30 ) q O(R 30 ) q OR 31 , \u2014R 30 OC(\u2550O)R 31 , \u2014R 30 OC(\u2550O)OR 31 , \u2014R 30 OC(\u2550O)NHR 31 , \u2014R 30 OC(\u2550O)N(R 31 ) 2 , optionally substituted alkyloxyalkyl, optionally substituted acyloxyalkyl, optionally substituted alkyloxycarbonyloxyalkyl, optionally substituted cycloalkyloxycarbonyloxyalkyl, optionally substituted aryloxycarbonyloxyalkyl, or optionally substituted alkyl-[1,3]dioxol-2-one;\n each q are independently 1, 2, 3, 4, 5, or 6; \n each R 30  are independently \u2014CH 2 \u2014, \u2014CH(R 32 )\u2014, or \u2014C(R 32 ) 2 \u2014; \n each R 31  are independently optionally substituted C 1 -C 12  alkyl, optionally substituted alkoxyalkyl, optionally substituted C 1 -C 12  alkenyl, optionally substituted C 1 -C 12  alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylcycloalkyl, optionally substituted alkylheterocycloalkyl, optionally substituted alkylaryl, or optionally substituted alkylheteroaryl; or \n two R 31  are taken together with the nitrogen to which they are attached to form a heterocycloalkyl; \n each R 32  is independently optionally substituted C 1 -C 6  alkyl; \n or two R 32  are taken together with the carbon to which they are attached to form a cycloalkyl; \n \n R a , R b , and R c  are independently hydrogen, fluoro, chloro, bromo, optionally substituted C 1 -C 6  alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, \u2014OR 4 , \u2014N(R 4 R 5 ), or \u2014SR 4 ; \n R d , R 4  and R 5  are independently hydrogen, \u2014OH, \u2014CN, \u2014CF 3 , optionally substituted C 1 -C 6  alkyl, optionally substituted alkoxyalkyl, optionally substituted hydroxyalkyl, optionally substituted aminoalkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aralkyl, optionally substituted heteroaralkyl, (poly-ethylene-glycol)-ethyl, or an optionally substituted saccharide; \n or R 4  and R 5  are taken together with the nitrogen to which they are attached to form a heterocycloalkyl.

Metadata:
- Claim Count in Document: 359.0
- Percentile: 94.0
- Lexical Diversity: 1.57692
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15675253', '15435097', '15162395', '15922376', '14773717']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.793343357709282
- 35 USC 102 Novelty (BERT): 0.5741568828905446
- Combined Prediction Score: 0.7714247102274082
- Mean Citation Score: 406.422242
- Max Citation Score: 442.13254000000006
- Similarity Product: 420.501872025528

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test