PATENT CLAIM ANALYSIS

Application Number: 16153108
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-03
Patent Classification: ["435", "006120"]

Abstract:
Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g., translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5′ and 3′ regions of the gene. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5′ portion of a target gene relative to the 3′ region of the target gene.

Claim (Index 21):
A method for distinguishing prostate cancer from benign prostate hyperplasia in a subject suspected of having prostate cancer comprising:\n (a) amplifying a 5\u2032 region of a TMPRSS2 gene transcript, in a biological sample from the subject with one or more 5\u2032 target primer pairs which are complementary to the 5\u2032 region of the TMPRSS2 gene; (b) amplifying a 3\u2032 region of the TMPRSS2 gene transcript, if present, in the biological sample with one or more 3\u2032 target primer pairs which are complementary to the 3\u2032 region of the TMPRSS2 gene; (c) detecting the amounts of amplification products produced by the one or more 5\u2032 target primer pairs and the one or more 3\u2032 target primer pairs; and (d) diagnosing the subject as having prostate cancer when the relative expression level of the 5\u2032 region to the 3\u2032 region of the target gene is above a cutoff level, and diagnosing the subject as having benign prostate hyperplasia when the relative expression level relative expression of the 5\u2032 region to the 3\u2032 region of the target gene is below the cutoff level.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 97.0
- Lexical Diversity: 1.62069
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13848974', '15372752', '12786266', '14454124', '14699380']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6854467223960344
- 35 USC 102 Novelty (BERT): 0.6244570852128638
- Combined Prediction Score: 0.6793477586777174
- Mean Citation Score: 565.607158
- Max Citation Score: 586.93024
- Similarity Product: 535.0085902626802

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test