PATENT CLAIM ANALYSIS

Application Number: 15749963
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "235500"]

Abstract:
A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula I.

Claim (Index 1):
A compound of formula I: or a pharmaceutically acceptable enantiomer, salt, or solvate thereof, wherein:\n X1 and X2 represent each independently H, halogen, OH, OR7; or C1-C4 alkyl;\n R 1 , R 2 , and R 3  are independently: H, halogen, cyano, R 7 , OR7, NR7R8, CONR7, N(R7)COR8, SO2R7, or alkylNR7R8; \n Q is H or COR7 or CONR7R8; \n R7 and R8 are independently (i) H, (ii) NH2, (iii) C1 to C6 branched or unbranched alkyl, optionally substituted with one to three substituents selected from one or more of oxo, amino, OH, halogen, or C1 to C4 alkyl, (iv) a C1-C3 alkyl-heterocycle or (v) a heterocycle, wherein the heterocycle of (iv) or (v) is an optionally substituted five or six-membered heterocycle in which the substituent is oxo, OH, NH2, or a C1 to C3 alkyl which is optionally substituted with one to three substituents selected from one or more of a halogen, alkyl, OH, oxo, or amino; \n A1 and A2 are independently (i) H, (ii) halogen, (iii) OH, (iv) SO2R5, (v) SO2NR5R6, wherein R5 and R6 are as defined below in (v\u2032)-(vii\u2032) or NR5R6 optionally together form a heterocycle ring of 4, 5 or 6 members having 1, 2 or 3 heteroatoms, said heterocycle being optionally substituted with 1, 2 or 3 substituents selected from one or more of C1 to C6 alkyl, OH, halogen, amino, SO2, or oxo, (vi) a C1-C4 alkyl optionally substituted with one to three substituents selected from one or more of a halogen, alkyl, OH, oxo, or amino, or (vii) (C1-C2)ONR5R6, \n R5 and R6 are independently: (I\u2032) H, (ii\u2032) oxo, (iii\u2032) amino, or (iv\u2032) a group, optionally substituted, selected from:\n (v\u2032) C1-C6 alkyl, linear or branched, optionally substituted with up to three substituents selected from one or more of halogen, hydroxyl, OR9, COOR9, CONR9R10, NR9COR10, NR9R10, SO2R9, SO2NR9R10, NR9SO2R10, SOR9, aryl, or CO-alkyl, \n (vi\u2032) heterocyclyl or C1-C3 alkyl-heterocyclyl, the heterocyclyl being optionally substituted with up to three substituents which are selected from one or more of halogen, hydroxyl, oxo, OR9, COOR9, CONR9R10, NR9COR10, NR9R10, SO2R9, SO2NR9R10, NR9SO2R10, SO2R9, aryl, CO-alkyl, a five or six membered heterocycle having 2 N atoms in its backbone; a piperidine substituted with F and three OH, or alkyl, the alkyl group being optionally substituted by one to three groups selected from one or more of halogen, hydroxyl, oxo, amino or COOH; \n (vii\u2032) cycloalkyl, optionally substituted with up to three substituents selected from halogen, hydroxyl, OR9, COOR9, CONR9R10, NR9COR10, NR9R10, SO2R9, SO2NR9R10, NR9SO2R10, SO2R9, aryl, CO-alkyl, or C1-C6 alkyl which is optionally substituted by one or more groups selected from halogen, hydroxyl, amino or COOH; \n R9 and R10 represent each independently a hydrogen atom or a group, optionally substituted, selected from C1-C6 alkyl, wherein when substituted, the C1-C6 alkyl has one, two or three groups selected from one or more halogen, hydroxyl, oxo, amino or COOH, heterocyclyl, aryl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, or alkylheteroaryl, wherein when substituted, the aryl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, alkylheteroaryl has up to three substituents which are one or more of halogen, hydroxyl, oxo, OR9, COOR9, CONR9R10, NR9COR10, NR9R10, SO2R9, SO2NR9R10, NR9SO2R10, SO2R9, CO-alkyl, or amino; \n \n and provided that:\n if one of A1 or A2 is H, halogen, OH, or the optionally substituted C1 to C4 alkyl, then the other is not H, halogen, OH, or the optionally substituted C1 to C4 alkyl; \n if A1, X1, X2, R1, R2, R3 are each H, then A2 is not COONH2; \n if A2 is H, X1 is CH3, R1 and R2 are each H, and R2 is halogen, then A1 is not SO2NH2.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 88.0
- Lexical Diversity: 1.88679
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14619589', '15072534', '14076016', '14765556', '15546251']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8042312454789433
- 35 USC 102 Novelty (BERT): 0.5812359549225309
- Combined Prediction Score: 0.7819317164233021
- Mean Citation Score: 378.49669200000005
- Max Citation Score: 465.86142
- Similarity Product: 458.7885645680772

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test