PATENT CLAIM ANALYSIS

Application Number: 16126323
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["544", "385000"]

Abstract:
Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphophoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

Claim (Index 15):
A method of preparing a diketopiperazine of Formula I (n=1-7) comprising: mixing 4-nitrophenol, an inorganic metallic base, and ethyl fumaryl chloride in an organic solvent to produce a monoethyl fumarate ester; adding an aminoalkyl-diketopiperazine having two primary amine functional groups; wherein the mono-ethyl fumarate ester is reacted with the aminoalkyl-diketopiperazine in situ without purification.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 97.0
- Lexical Diversity: 1.72727
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14949489', '13834106', '14629046', '15953817', '14942410']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7608578108093302
- 35 USC 102 Novelty (BERT): 0.6711393834845238
- Combined Prediction Score: 0.7518859680768496
- Mean Citation Score: 448.361004
- Max Citation Score: 670.2867
- Similarity Product: 647.328247800207

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test