PATENT CLAIM ANALYSIS

Application Number: 15575988
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["800", "018000"]

Abstract:
An object of the present invention is to provide a mouse that enables the functions of human NK cell to be studied. A DNA consisting of a nucleotide sequence represented by SEQ ID NO: 1, which is a gene region comprising a DNA in which a cDNA sequence encoding interleukin 15 (IL-15) is operably ligated to a cDNA sequence encoding the signal peptide of human interleukin (IL-2), is inserted to immunodeficient mouse cDNA. In NOD-scid, IL-2rγ null -hIL-15 Tg mice thus generated, hCD56 +  cell having a concentration sufficient for conducting in vivo study on human mature NK cell are detected for at least 6 months after transplantation.

Claim (Index 14):
The immunodeficient mouse according to  claim 3 , wherein the immunodeficient mouse is capable of suppressing growth of human tumor in vitro in the presence of a cytokine after transplantation of a human peripheral blood-derived human NK cell.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.5
- Patent Class: 800.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['10221549', '12620469', '11914649', '14420318', '10533796']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6325299230979884
- 35 USC 102 Novelty (BERT): 0.5560210255907947
- Combined Prediction Score: 0.624879033347269
- Mean Citation Score: 401.718952
- Max Citation Score: 469.75204
- Similarity Product: 357.6283727786875

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test