PATENT CLAIM ANALYSIS

Application Number: 15746254
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["540", "001000"]

Abstract:
Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.

Claim (Index 11):
A process for preparing the fused ring pyrimidine compound according to  claim 1 , which is any one of the following processes 1-13,\n process 1 comprises carrying out a substitution reaction with compound 1-a and a methylation reagent in an organic solvent and in the presence of a base to give compound I; process 2 comprises carrying out a substitution reaction with compound II and compound VI in an organic solvent and in the presence of a catalyst to give compound I; process 3 comprises carrying out a coupling reaction with compound III and compound VII in an organic solvent and water and in the presence of a base and a palladium catalyst to give compound I; wherein, A is Br or I; process 4 comprises carrying out a substitution reaction with compound 9-a and 2-(4-piperidyl)-2-propanol in an organic solvent and in the presence of a base to give compound 9; process 5 comprises carrying out a substitution reaction with compound 17-a and morpholine in an organic solvent and in the presence of a base to give compound 17; process 6 comprises carrying out a substitution reaction with compound 17-a and pyrrolidine in an organic solvent and in the presence of a base to give compound 18; process 7 comprises carrying out a substitution reaction with compound 17-a and N-methylpiperazine in an organic solvent and in the presence of a base to give compound 19; process 8 comprises carrying out a condensation reaction with compound 23-b and azetidine in an organic solvent and in the presence of a base, N-hydroxybenzotriazole and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride to give compound 23; process 9 comprises deprotecting compound IV in an organic solvent and in the presence of an acid to give compound I; wherein R 4  is process 10 comprises carrying out a substitution reaction with compound 31 and 2-haloethanol in an organic solvent and in the presence of a base to give compound 34; process 11 comprises carrying out a condensation reaction with compound 32 and 2-hydroxyacetic acid in an organic solvent and in the presence of a base, 1-hydroxybenzotriazole and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride to give compound 36; process 12 comprises carrying out a reduction amination reaction with compound 40-a, dimethylamine and sodium triacetoxyborohydride in an organic solvent and in the presence of an acid to give compound 40; process 13 comprises carrying out a condensation reaction with compound 31 and ethyl chloroformate in an organic solvent and in the presence of a base to give compound 50;

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.83582
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14391386', '15025618', '15559181', '15568999', '15314938']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7479751567219756
- 35 USC 102 Novelty (BERT): 0.5303716312297106
- Combined Prediction Score: 0.7262148041727491
- Mean Citation Score: 330.97676
- Max Citation Score: 348.54816
- Similarity Product: 283.3541847823334

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test