PATENT CLAIM ANALYSIS

Application Number: 16259062
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-06
Patent Classification: ["424", "140100"]

Abstract:
The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) in an individual. These include enzyme linked immunosorbent assays (ELISAs) to measure antibody titers against neuronal antigens present in the brain; the neuronal antigens include lysoganglioside, tubulin, dopamine receptor D1, dopamine receptor D2, serotonin receptor 5HT2A, and serotonin receptor 5HT2C. Antibody titers against at least four of these neuronal antigens are required in the present methods; preferably antibody titers against all of these neuronal antigens are measured. A final assay is used to quantify calcium/calmodulin-dependent protein kinase activity using a neuronal cell line. The results of these analyses or tests are then combined using an algorithm to determine whether a PANS or PANDAS diagnosis is appropriate for the individual. Depending on the diagnosis, an appropriate treatment can be determined.

Claim (Index 7):
The method of  claim 3 , wherein the one or more assay plates each separately comprises one of the lysoganglioside, the tubulin, the dopamine receptor D1, and the dopamine receptor D2.

Metadata:
- Claim Count in Document: 18.0
- Percentile: 99.0
- Lexical Diversity: 1.76238
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15783541', '15045146', '15031126', '09425956', '14940983']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7089843610940458
- 35 USC 102 Novelty (BERT): 0.6070955271377314
- Combined Prediction Score: 0.6987954776984143
- Mean Citation Score: 323.02307
- Max Citation Score: 545.4215
- Similarity Product: 457.2448481810689

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test