PATENT CLAIM ANALYSIS

Application Number: 16419353
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-09
Patent Classification: ["436", "060000"]

Abstract:
Compounds and methods for treating diseases mediated by a P2X 3  and/or a P2X 2/3  receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 1  and R 8  are as defined herein.

Claim (Index 10):
A method for treating a disease mediated by a P2X 3  or P2X 2/3  receptor antagonist, said method comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n X is: \u2014O\u2014; \n Y is: hydrogen; or \u2014NR d R e  wherein one of R d  and R e  is hydrogen, and the other is: hydrogen; alkyl; cycloalkyl; cycloalkylalkyl; haloalkyl; haloalkoxy; hydroxyalkyl; alkoxyalkyl; acetyl; alkylsulfonyl; alkylsulfonylalkyl; aminocarbonyloxyalkyl; hydroxycarbonylalkyl; hydroxyalkyloxycarbonylalkyl; aryl; aralkyl; arylsulfonyl; heteroaryl; heteroarylalkyl; heteroarylsulfonyl; heterocyclyl; or heterocyclylalkyl;\n D is an optional oxygen; \n R 1  is isopropyl; \n R 2 , R 3 , R 4  and R 5  each independently is: hydrogen; alkyl; alkenyl; amino; halo; amido; haloalkyl; alkoxy; hydroxy; haloalkoxy; nitro; hydroxyalkyl; alkoxyalkyl; hydroxyalkoxy; alkynylalkoxy; alkylsulfonyl; arylsulfonyl; cyano; aryl; heteroaryl; heterocyclyl; heterocyclylalkoxy; aryloxy; heteroaryloxy; aralkyloxy; heteroaralkyloxy; optionally substituted phenoxy; \u2014(CH 2 ) m \u2014(Z)\u2014(CO)\u2014R f  or \u2014(CH 2 ) m \u2014(Z)\u2014SO 2 \u2014(NR) n \u2014R f  where m and n each independently is 0 or 1, Z is O or NR 9 , R f  is hydrogen, alkyl, hydroxy, alkoxy, amino, hydroxyalkyl or alkoxyalkyl, and each R g  is independently hydrogen or alkyl; or R 3  and R 4  may together form an alkylene dioxy; or R 3  and R 4  together with the atoms to which they are attached may form a five or six-membered ring that optionally includes one or two heteroatoms selected from O, S and N; or R 2  and R 3  may together form an alkylene dioxy; or R 2  and R 3  together with the atoms to which they are attached may form a five or six-membered ring that optionally includes one or two heteroatoms selected from O, S and N; \n R 6  is: hydrogen; alkyl; halo; haloalkyl; amino; or alkoxy; and \n one of R 1  and R 8  is hydrogen, and the other is: hydrogen; alkyl; cycloalkyl; cycloalkylalkyl; haloalkyl; haloalkoxy; hydroxyalkyl; alkoxyalkyl; acetyl; alkylsulfonyl; alkylsulfonylalkyl; aminocarbonyloxyalkyl; hydroxycarbonylalkyl; hydroxyalkyloxycarbonylalkyl; aryl; aralkyl; arylsulfonyl; heteroaryl; heteroarylalkyl; heteroarylsulfonyl; heterocyclyl; or heterocyclylalkyl.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 100.0
- Lexical Diversity: 1.51724
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14453409', '12963413', '11510015', '11071555', '13186078']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7669358642095511
- 35 USC 102 Novelty (BERT): 0.6133137374578629
- Combined Prediction Score: 0.7515736515343823
- Mean Citation Score: 497.6871560000001
- Max Citation Score: 595.3977
- Similarity Product: 542.5222243101239

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test