PATENT CLAIM ANALYSIS

Application Number: 15769113
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "243000"]

Abstract:
PRODRUGS OF IMIDAZOTRIAZINE COMPOUNDS AS CK2 INHIBITORS The invention provides pharmaceutically active compounds of formula (I) and prodrugs thereof. The formula (I) 2-(aminophenylamino)-4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazine derivatives inhibit CK2 protein kinase activity, thereby making them useful for treating cancer, psoriasis and rheumatoid arthritis.

Claim (Index 2):
The compound of  claim 1  or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein\n R 1  is H, halogen, or CN; \n R 2  is H or \u2014C(\u2550O)O(CR c R c ) r OC(\u2550O)R d ; \n R 3  is methyl, ethyl, or cyclopropyl; \n R 4  and R 4  together with the nitrogen atom to which they are both attached form a 4- to 6-membered saturated monocyclic heterocycle containing carbon atoms and 0-1 NR 5 , wherein the heterocycle is substituted with 1-3 R 6 ; \n R 5  is \u2014CHR c OR b , \u2014CHR c S(O) p R c , \u2014CHR c NR a R a , \u2014CHR c C(\u2550O)NR a R a , \u2014CHR c C(\u2550O)NR a S(O) p R c , \u2014CHR c NHC(\u2550O)OR b , \u2014CHR c OC(\u2550O)R d , \u2014CHR c S(O) 2 NR a R a , or \u2014CHR c NR a S(O) p R c ; \n R 6  is H, \u2014OR b , \u2014NHC(\u2550O)OR b , or \u2014(CR c R c ) r C(\u2550O)NR a R a ; \n R a , is H or C 1-6  alkyl; \n R b  is H or C 1-6  alkyl; \n R c  is H or C 1-6  alkyl; \n R d  is straight or branched, saturated or unsaturated alkyl, allyl, cycloalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each optionally substituted with C 1-2  alkyl, \u2014C(O)OH, or \u2014OP(O)(OH) 2 ; and \n r is zero, 1, 2 or 3.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 91.0
- Lexical Diversity: 1.28261
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13940619', '14532218', '14414152', '14191861', '12575589']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8257326363392653
- 35 USC 102 Novelty (BERT): 0.5515423976577719
- Combined Prediction Score: 0.798313612471116
- Mean Citation Score: 394.033546
- Max Citation Score: 415.17645
- Similarity Product: 352.88044270716904

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test