PATENT CLAIM ANALYSIS

Application Number: 15745437
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "218000"]

Abstract:
The present invention relates quinazolinone compounds of Formula (I), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses; wherein the compounds or pharmaceutical compositions disclosed herein can be used for antagonizing the orexin receptor. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing neurological and psychiatric disorders and diseases of the central nervous system in mammals, especially in humans.

Claim (Index 1):
A compound having Formula (I) or a stereoisomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein, G is a 5- to 6-membered heterocycloalkyl or heteroaryl group containing at least one nitrogen, wherein G is optionally substituted with one or more R 8 ; each R 1  is independently H, D, F, Cl, Br, I, OH, NH 2 , NO 2 , CN, N 3 , C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  hydroxyalkyl, C 1-6  alkylamino, C 3-12  carbocyclyl, 3- to 12-membered heterocyclyl, C 6-10  aryl or 5- to 12-membered heteroaryl, wherein each R 1  is optionally and independently substituted with one or more R 8 ; each R 2  is independently H, D, F, Cl, Br, I, OH, NH 2 , NO 2 , CN, N 3 , C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, C 1-4  alkylamino, C 1-4  hydroxyalkyl or C 1-4  haloalkyl; each R 3  is independently H, D, F, Cl, Br, I, OH, NH 2 , NO 2 , CN, N 3 , C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-12  carbocyclyl, 3- to 12-membered heterocyclyl, C 6-10  aryl or 5- to 12-membered heteroaryl, \u2014(CR 4 R 4a ) q \u2014OR 7 , \u2014(CR 4 R 4a ) q \u2014NR 5 R 6 , \u2014(CR 4 R 4a ) q S(\u2550O) r R 7 , \u2014(CR 4 R 4a ) q S(\u2550O) 2 NR 5 R 6 , \u2014(CR 4 R 4a ) q C(\u2550O)R 7 , \u2014(CR 4 R 4a ) q OC(\u2550O)R 7 , \u2014(CR 4 R 4a ) q C(\u2550O)OR 7 , \u2014(CR 4 R 4a ) q \u2014N(R 5 )C(\u2550O)R 7 , \u2014C(\u2550NR 7 )NR 5 R 6 , \u2014N(R 7 )C(\u2550O)NR 5 R 6 , \u2014(CR 4 R 4a ) q \u2014N(R 5 )S(\u2550O) r R 7  or \u2014(CR 4 R 4a ) q C(\u2550O)NR 5 R 6 , wherein each R 3  is optionally and independently substituted with one or more R 8 ; wherein each R 4  and R 4a  is independently H, D, F, Cl, Br, I, CN, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, C 1-4  alkylamino, C 1-4  haloalkoxy, C 1-4  haloalkylamino, C 3-8  carbocyclyl, 3- to 8-membered heterocyclyl, C 6-10  aryl or 5- to 6-membered heteroaryl; each R 5 , R 6  and R 7  is independently H, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkenyl, C 3-8  carbocyclyl, (C 3-6  cycloalkyl)-(C 1-4  alkylene)-, 3- to 8-membered heterocyclyl, (3- to 6-membered heterocyclyl)-(C 1-4  alkylene)-, phenyl, (C 6-10  aryl)-(C 1-4  alkylene)-, 5- to 6-membered heteroaryl or (5- to 6-membered heteroaryl)-(C 1-4  alkylene)-, or R 5  and R 6  together with the nitrogen atom to which they are attached, independently and optionally form 3- to 6-membered heterocyclyl, wherein each C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl and C 3-8  carbocyclyl is optionally and independently substituted with one or more substituents independently selected from D, F, Cl, Br, OH, NH 2 , CN, N 3 , C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy or C 1-4  alkylamino; each R 8  is independently H, D, F, Cl, Br, I, \u2550O, OH, NH 2 , NO 2 , CN, N 3 , C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, C 1-4  alkoxy, C 1-4  alkylamino, C 1-4  haloalkyl, C 1-4  haloalkoxy, C 1-4  hydroxyalkyl or C 1-4  haloalkylamino; each m and n is independently 0, 1, 2, 3, or 4; t is 0 or 1; p is 0, 1, 2, 3, 4, or 5; each r is independently 0, 1 or 2; and each q is independently 0, 1, 2, 3, or 4.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 86.0
- Lexical Diversity: 1.61538
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16326189', '15314932', '16327335', '12576375', '13587936']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7847947194791606
- 35 USC 102 Novelty (BERT): 0.5299377044392184
- Combined Prediction Score: 0.7593090179751664
- Mean Citation Score: 328.7722179999999
- Max Citation Score: 336.8668
- Similarity Product: 274.23788987846376

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test