PATENT CLAIM ANALYSIS

Application Number: 16124578
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["514", "234200"]

Abstract:
The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the formula (I) is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R 1 , R 2  and R 3  which have the meanings given in the specification, and pharmaceutically acceptable salts thereof.

Claim (Index 18):
A method of treating an autoimmune disease in a subject, comprising administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein:\n the dotted lines [. . . . ] in the ring represent an optional bond which may be present in any stable combination; \n R 1  is selected from hydrogen and alkyl; \n R 2  is -A-R 4 . \n A is arylene or tetrasubstituted arylene where the substituent is halogen. \n R 3  is selected from hydroxy and amino; \n R 4  is selected from an optionally substituted aryl and an optionally substituted heteroaryl; \n wherein the optional substituent for the aryl and the heteroaryl selected from one or more R 5 ; \n R 5  is selected from alkyl and \u2014(CH 2 ) n N(R a )R b ; \n R a  and R b  are each independently selected from hydrogen, alkyl and \u2014C(O)alkyl; \n alternatively R a  and R b  can be taken together with the nitrogen atom to which they are attached to form an optionally substituted 4-6 membered heterocyclyl containing 0-2 additional heteroatoms independently selected from O and N; wherein the optional substituent for the 4-6 membered heterocyclyl is alkyl; and \n \u2018n\u2019 is an integer selected from 0 and 1.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 97.0
- Lexical Diversity: 1.57143
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15494820', '15718961', '14784708', '15737351', '13262640']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7359623097134876
- 35 USC 102 Novelty (BERT): 0.5242109240531837
- Combined Prediction Score: 0.7147871711474573
- Mean Citation Score: 294.006844
- Max Citation Score: 328.6353
- Similarity Product: 283.88527610465883

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test