PATENT CLAIM ANALYSIS

Application Number: 15565802
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-05
Patent Classification: ["514", "223800"]

Abstract:
Novel compounds of formula (II) are disclosed. Compounds of formula (II) comprise ornithine derivatives or compounds that may metabolize to ornithine. Also disclosed are methods for the treatment of neurodegenerative diseases such as Alzheimer's Disease using compounds of formula (II).

Claim (Index 5):
A compound selected from the group consisting of: wherein\n R 1  is alkyl of 1-10 carbons, substituted or unsubstituted, aryl of 6 to 10 carbons, substituted or unsubstituted, or heteroaryl of 5 to 9 carbons, substituted or unsubstituted; \n R 2  and R2\u2032 are independently hydrogen, alkyl of 1-10 carbons, substituted or unsubstituted, aryl of 6 to 10 carbons, substituted or unsubstituted, or heteroaryl of 5 to 9 carbons, substituted or unsubstituted; \n R 3  is hydrogen or \n (a) C 1 -C 5 -alkyl, \n (b) C 2 -C 5 -alkenyl, \n (c) C 2 -C 5 -alkynyl, (d) (CH 2 ) p NR 12 R 13 , \n (e) (CH 2 ) 5 CH(R 7 ) (CH 2 ) 5 O 2 CR 8 , \n (g) \u2014(CH 2 ) p CO 2 R 10 , or\n (i) C 1 -C 5  alkyl substituted by one or more F; \n R is independently a hydrogen, a cation or alkyl of 1-10 carbons, substituted or unsubstituted, aryl of 6 to 10 carbons, substituted or unsubstituted, or heteroaryl of 5 to 9 carbons, substituted or unsubstituted; \n R 4  is hydrogen, alkyl of 1-10 carbons, substituted with one or more F, or unsubstituted, aryl of 6 to 10 carbons, substituted or unsubstituted, or heteroaryl of 5 to 9 carbons, substituted or unsubstituted; \n R 5  is alkyl of 1-10 carbons, substituted, substituted with one or more F, or unsubstituted, aryl of 6 to 10 carbons, substituted or unsubstituted, or heteroaryl of about 5 to 9 carbons, substituted or unsubstituted; \n R 6  is alkyl of about 1-10 carbons, substituted with one or more F, or unsubstituted, aryl of 6 to 10 carbons, substituted or unsubstituted, or heteroaryl of 5 to 9 carbons, substituted or unsubstituted; \n R 7  is H or C 1 -C 4 -alkyl, unsubstituted or substituted by one or more F; \n R 8  is \n (a) H, \n (b) C 1 -C 5 -alkoxy, \n (c) C 1 -C 5 -alkyl optionally substituted with a group consisting of:\n i) C 1 -C 5 alkoxy, \n ii) aryl, wherein aryl is phenyl or napthyl optionally substituted with one or two substituents selected from the group consisting of halo (F, Cl, Br, I), C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, \u2014NO 2 , \u2014S(O) r C 1 -C 5 -alkyl), \u2014OH, \u2014N  12 R 13 , \u2014CO 2 R 15 , and \u2014C v C w  where v=1 to 3 and w=1 to (2v+1), or \n iii) one or more F; \n \n R 9  is \n (a) C 1 -C 5 -alkyl,\n (b) \u2014C v F w , where v=1 to 3 and w=1 to (2v+1), or \n (c) C 1 -C 5 -alkyl optionally substituted with a group consisting of: \n i) C 1 -C 5 -alkoxy, \n ii) phenyl or phenyl substituted with at least one substituent selected from the group consisting of halo (F, Cl, Br, I), C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, \u2014NO 2 , \u2014S(O) r C 1-4 -alkyl), \u2014OH, \u2014NR 12 R 13 , \u2014CO 2 R 15 , and \u2014C v F w  where v=1 to 3 and w=1 to (2v+1), or \n iii) benzyl or benzyl substituted with at least one substituent selected from the group consisting of halo (F, Cl, Br, I), C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, \u2014NO 2 , \u2014S(O) r (C 1 -C 4 -alkyl), \u2014OH, \u2014NR 12 R 13 , \u2014CO 2 R 15 , and \u2014C v F w , where v=1 to 3 and w=1 to (2v+1); \n \n R 10  is \n (a) phenyl or phenyl substituted with at least one substituent selected from the group consisting of halo (F, Cl, Br, I), C 1-4 -alkyl, C 1 -C 4 -alkoxy, \u2014NO 2 , \u2014S(O) r (C 1 -C 4 -alkyl), \u2014OH, \u2014NR 12 R 13 , \u2014CO 2 R 15 , and \u2014C v F w  where v=1 to 3 and w=1 to (2v+1), or \n (b) benzyl or benzyl substituted with at least one substituent selected from the group consisting of halo (F, Cl, Br, I), C 1-4 -alkyl, C 1-4 -alkoxy, \u2014NO 2 , \u2014S(O) r (C 1 -C 4 -alkyl), \u2014OH, NR 12 R 13 , \u2014CO 2 R 15 , and \u2014C v F w \n where v=1 to 3 and w=1 to (2v+1); \n R 11  is H, C 1 -C 5 -alkyl or benzyl; \n R 12  and R 13  are independently H, C 1 -C 5 -alkyl, phenyl or benzyl; \n R 15  is H, C 1 -C 5 -alkyl, or NR 12 R 13 ; \n p is 1-5; \n r is 0-2; \n s and s\u2032 are 0-5; \n t is 0 or 1; \n R 8  is independently a value of R 8  other than (a) H and (b) C 1 -C 5 -alkoxy; and \n R 10  is \u2014SR; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 88.0
- Lexical Diversity: 1.5625
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10587121', '11346524', '11665520', '10755505', '11665943']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7622444220505632
- 35 USC 102 Novelty (BERT): 0.490383545268975
- Combined Prediction Score: 0.7350583343724044
- Mean Citation Score: 197.448236
- Max Citation Score: 198.67493
- Similarity Product: 145.74586036167324

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test