PATENT CLAIM ANALYSIS

Application Number: 15905118
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-11
Patent Classification: ["514", "044000"]

Abstract:
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.

Claim (Index 7):
A method for treating or preventing a fibrotic disorder in a subject in need thereof, the method comprising:\n administering to the subject a therapeutically effective amount for treating or preventing a fibrotic disorder of a double stranded nucleic acid molecule comprising a guide strand, with a minimal length of 16 nucleotides, and a passenger strand forming a double stranded nucleic acid, having a double stranded region and a single stranded region, the double stranded region having 8-15 nucleotides in length, the single stranded region having 4-12 nucleotides in length, wherein the single stranded region comprises 2-12 phosphorothioate modifications, wherein at least 40% of the nucleotides of the double stranded nucleic acid molecule are modified, and wherein the double stranded nucleic acid molecule is directed against COX-2.

Metadata:
- Claim Count in Document: 49.0
- Percentile: 88.0
- Lexical Diversity: 1.08696
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15041738', '14104450', '13120315', '13120342', '14278900']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8502583460616381
- 35 USC 102 Novelty (BERT): 0.6976083699196716
- Combined Prediction Score: 0.8349933484474414
- Mean Citation Score: 700.4582519999999
- Max Citation Score: 723.1773
- Similarity Product: 715.623282964611

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test