PATENT CLAIM ANALYSIS

Application Number: 15742725
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["514", "391000"]

Abstract:
Presently disclosed are methods of treating cancer comprising administering a MEK inhibitor in combination with a proteasome inhibitor. In some embodiment, the cancer is a solid tumor. In some instances, the cancer has at least one mutation chosen from a NF1, RAS (including N-, K-, and H-RAS), RAF (including A-, B-, and C-RAF), and MEK (including MEK1 and MEK2) mutation. In some embodiments, the cancer is resistant to treatment with at least one of a proteasome inhibitor or a MEK inhibitor. In some embodiments, the combination therapy produces a synergistic effect.

Claim (Index 3):
The method of  claim 2 , wherein the solid tumor is biliary (cholangiocarcinoma), bladder cancer, brain cancer, breast cancer, cervical cancer, colorectal cancer, endometrial cancer, epidermoid carcinoma, esophageal carcinoma, gallbladder cancer, gastric (stomach) cancer, glioblastoma, glioma, head and neck cancers, hepatocellular (liver) carcinoma, kidney cancer, lung cancer, mesothelioma, non-small cell lung cancer, ovarian, pancreatic cancer, pediatric malignancies, prostate cancer, renal cancer, sarcomas, skin cancer (including melanoma), small bowel adenocarcinoma, small cell lung cancer, testicular cancer, or thyroid cancer.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 86.0
- Lexical Diversity: 1.98246
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14387735', '13139060', '15011003', '14775009', '13825713']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7916423453960602
- 35 USC 102 Novelty (BERT): 0.5183170543399951
- Combined Prediction Score: 0.7643098162904537
- Mean Citation Score: 259.778738
- Max Citation Score: 278.75934
- Similarity Product: 166.85049514736653

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test