PATENT CLAIM ANALYSIS

Application Number: 16061597
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "362000"]

Abstract:
Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Claim (Index 1):
A compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein: m is 0, 1, 2, 3, 4, 5 or 6; X is O or S; ring A is a 5-membered heterocyclyl selected from 1,2,5-oxadiazolyl and 1,2,5-thiadiazolyl; each of which is optionally substituted with:\n (i) halogen, \n (ii) C 1-6  alkyl, optionally substituted with one to four halogens, \n (iii) C 3-6  cycloalkyl, \n (iv) C 2-6  alkenyl, \n (v) C 2-6  alkynyl, \n (vi) aryl, \n (vii) heteroaryl, \n (viii) CN, \n (ix) NO 2 , \n (x) OR 4 , \n (xi) SR 4 , \n (xii) C(O)R 4 , \n (xiii) NR 4 R 4 , \n (xiv) S(O)R 4 , and \n (xv) S(O) 2 R 4 ; \n R is selected from:\n (a) hydrogen, \n (b) OR a , \n (c) C 3-6 cycloalkyl, optionally substituted with one to four substituents independently selected from: \n (i) C 1-6 alkyl, \n (ii) CN, and \n (iii) \u2014(C\u2550O)\u2014O\u2014C 1-6 alkyl, \n (d) aryl, optionally substituted with one to four substituents independently selected from: \n (i) halogen, \n (ii) C 1-6 alkyl, optionally substituted with one to three halogens, \n (iii) oxo, and \n (iv) \u2014S(O) 2 \u2014NH\u2014R 4 , \n (e) a 4-, 5- or 6-membered heterocyclyl, optionally substituted with one to four substituents independently selected from: \n (i) halogen, \n (ii) C 1-6 alkyl, optionally substituted with one to three halogens, \n (iii) oxo, \n (iv) \u2014S(O) 2 \u2014NH\u2014R 4 , \n (v) \u2014(C\u2550O)\u2014C 1-6 alkyl, and \n (vi) \u2014(C\u2550O)NH\u2014R 4 , \n (f) CN, \n (g) \u2014(C\u2550O)\u2014R a , \n (h) \u2014(C\u2550O)NH\u2014R a , \n (i) \u2014P(O)(OR a ) 2 , \n (j) \u2014P(O)(NHR a )(OR a ), \n (k) \u2014P(O)(NR 4 R a ) 2 , \n (l) C 2-4 alkynyl, \n (m) \u2014NR x R y , wherein each of R x  and R y  is independently selected from: \n (i) hydrogen, \n (ii) C 1-6 alkyl, optionally substituted with a 4-, 5- or 6-membered heterocyclyl, \n (iii) C 3-6 cycloalkenyl, optionally substituted with one to four substituents independently selected from NH\u2014R a , oxo, and 4-, 5- or 6-membered heterocyclyl, \n (iv) C 2-4 alkenyl, optionally substituted with one to four substituents independently selected from NR 4  and NO 2 , \n (v) \u2014(C\u2550O)\u2014R a , \n (vi) \u2014(C\u2550O)\u2014C 3-6 cycloalkyl, \n (vii) \u2014(C\u2550O)\u2014NR 4 R a , \n (viii) aryl, \n (ix) heteroaryl, \n (x) \u2014(C\u2550NH)(NH 2 )\u2014CN, \n (xi) \u2014S(O) 2 \u2014R a , and \n (xii) \u2014S(O) 2 \u2014NH\u2014R a ; \n R 1  is aryl, optionally substituted with one to four substituents independently selected from:\n (a) halogen, \n (b) C 1-6  alkyl, optionally substituted with one to four halogens, \n (c) CN, \n (d) C 2-6  alkenyl, \n (e) C 2-6  alkynyl, \n (f) C 3-6 cycloalkyl, \n (g) OR 4 , \n (h) SR 4 , \n (i) C(O)R 4 , \n (j) C(O)NR 4 R 4 , \n (k) S(O)R 4 , \n (l) S(O) 2 R 4 , and \n (m) S(O) 2 NR 4 R 4 ; \n each occurrence of R 2  and R 3  is independently selected from:\n (a) R 4 , \n (b) OH, \n (c) NH\u2014R 4 , \n (d) NH\u2014(C\u2550O)\u2014R 4 , \n (e) halogen, \n (f) C 3-6 cycloalkyl, and \n (g) C 1-6 alkoxy; \n or R 2  and R 3  together form an oxo group; or R 2  and R 3  together with the carbon to which they are attached form a C 3-6 cycloalkyl group; each occurrence of R 4  is independently selected from hydrogen and C 1-6  alkyl; and each occurrence of R a  is independently selected from the group consisting of:\n (a) hydrogen, \n (b) C 1-6 alkyl, optionally substituted with one or three substituents independently selected from halogen, OR 4 , \u2014O\u2014(C\u2550O)\u2014O\u2014C 1-6 alkyl, \u2014(C\u2550O)\u2014O\u2014C 1-6 alkyl, aryl, and 4-, 5- or 6-membered heterocyclyl, \n (c) C 3-6 cycloalkyl, optionally substituted with one or three substituents independently selected from halogen, C 1-6 alkyl and OR 4 , \n (d) \u2014O\u2014C 1-6 alkyl, \n (e) \u2014(C\u2550O)\u2014O\u2014C 1-6 alkyl, \n (f) aryl, optionally substituted with C 1-6 alkyl, and \n (g) 4, 5- or 6-membered heterocyclyl, optionally substituted with \u2014C 1-6 alkyl or \u2014C 1-6 alkyl-OR 4 .

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 2.25
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13780510', '11641284', '15632986', '13734263', '11430441']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8237355328429701
- 35 USC 102 Novelty (BERT): 0.5886883510339427
- Combined Prediction Score: 0.8002308146620674
- Mean Citation Score: 485.00033600000006
- Max Citation Score: 496.86115
- Similarity Product: 440.6591981935322

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test