PATENT CLAIM ANALYSIS

Application Number: 16264466
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["514", "001100"]

Abstract:
A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

Claim (Index 67):
A method of providing a covalently-stabilized scaffold in living mammalian tissue, comprising:\n a) delivering to the living mammalian tissue a flowable solution comprising a plurality of spherical microgel particles without delivering cells to the living mammalian tissue, wherein the spherical microgel particles comprise a hydrogel material having a polymer backbone comprising poly(ethylene glycol) (PEG) pre-modified with an RGD peptide, K peptide, Q peptide, and a matrix metalloprotease (MMP)-degradable cross-linker; and b) annealing the spherical microgel particles using activated Factor XIII to crosslink a portion of the spherical microgel particles directly to adjacent spherical microgel particles to form the covalently-stabilized scaffold with interconnected pores, wherein the interconnected pores contain no crosslinked hydrogel therein and are large enough to accommodate penetration, migration, and growth of cells.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 99.0
- Lexical Diversity: 1.87342
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14481407', '16253707', '12449262', '13305088', '12094180']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6167426581754952
- 35 USC 102 Novelty (BERT): 0.5008134886353264
- Combined Prediction Score: 0.6051497412214784
- Mean Citation Score: 192.744784
- Max Citation Score: 197.25473
- Similarity Product: 132.45520446704506

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test