PATENT CLAIM ANALYSIS

Application Number: 16376216
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["424", "085700"]

Abstract:
Aspects of the disclosure provide fusion proteins that bind cells expressing one or more target molecules including, for example, one or more cell surface multisubunit signaling receptors (e.g., EGFRvIII-expressing cells that also express interferon receptors) and that induce anti-proliferative effects, and related compositions and methods for the treatment of cancer

Claim (Index 1):
A fusion protein comprising\n a Type 1 interferon protein domain comprising the sequence of SEQ ID NO: 18 or a sequence with one or two mutations relative to SEQ ID NO:18, the mutations selected from the group consisting of:\n L30A, R145A, M149A, E59A, H58A, and R150A; \n an antibody variable region element comprising\n a HCDR1 comprising amino acids 31-35 of SEQ ID NO: 15; \n a HCDR2 comprising amino acids 50-65 of SEQ ID NO: 15; \n a HCDR3 comprising amino acids 95-102 of SEQ ID NO: 15; \n a LCDR1 comprising amino acids 24-34 of SEQ ID NO: 16; \n a LCDR2 comprising amino acids 50-56 of SEQ ID NO: 16; and \n a LCDR3 comprising amino acids 89-97 of SEQ ID NO: 16; \n and which binds to EGFRvIII; and \n a linker that connects the protein domain and the antibody variable region element.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 100.0
- Lexical Diversity: 1.36585
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15307646', '12985122', '15359456', '12541062', '12610204']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7131251505968654
- 35 USC 102 Novelty (BERT): 0.652727968625891
- Combined Prediction Score: 0.7070854323997681
- Mean Citation Score: 379.304904
- Max Citation Score: 669.4451
- Similarity Product: 541.7326440528989

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test