PATENT CLAIM ANALYSIS

Application Number: 16069585
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["514", "215000"]

Abstract:
The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof wherein the variables R 1 , R 2 , R 3 , R 4 , R 5 , a and A are as defined herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D3-mediated (or D3-associated) disorders including, e.g., substance addiction, substance abuse, schizophrenia (e.g., its cognitive symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD or PD), Parkinson's disease, mania, anxiety, impulse control disorders, sexual disorders and depression.

Claim (Index 17):
A compound of  claim 1  selected from the group consisting of\n 6-cyclohexyl-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 6-(cyclopentyloxy)-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 4-[trans-3-(2-fluoroethoxy)cyclobutyl]-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(tetrahydro-2H-pyran-4-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-methylbenzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(tetrahydro-2H-pyran-2-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(2R)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(2S)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n N-(2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(2R)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n 4-(trans-1-fluoro-3-methoxycyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 6-(1-fluorocyclopentyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n N-[2-(difluoromethoxy)-7-propyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl]-4-(propan-2-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-5-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-methylbenzenesulfonamide; \n 4-ethoxy-N-[7-ethyl-2-(propan-2-yloxy)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl]benzenesulfonamide; \n 6-(cyclopentyloxy)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 6-cyclopentyl-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 6-(cyclobutyloxy)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 2-(cyclopentyloxy)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyrimidine-5-sulfonamide; \n 6-(1-fluorocyclohexyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d] azepin-3-yl)pyridine-3-sulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[trans-3-(2-fluoroethoxy)cyclobutyl]benzenesulfonamide; \n 4-(cis-3-ethoxycyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-(trans-3-ethoxycyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-6-(cis-1-hydroxy-3-methoxycyclobutyl)pyridine-3-sulfonamide; \n 6-cyclobutyl-5-fluoro-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d] azepin-3-yl)pyridine-3-sulfonamide; \n 6-(cis-1-fluoro-3-methylcyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n N-(2-methoxy-7-propyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-methylbenzene sulfonamide; \n 4-chloro-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl) benzenesulfonamide; \n 4-ethoxy-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl) benzenesulfonamide; \n 4-ethoxy-N-[2-methoxy-7-(2-methoxyethyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d] azepin-3-yl]benzenesulfonamide; \n 4-cyclopropyl-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-3,4-dihydro-2H-chromene-6-sulfonamide; \n 4-(1-methoxyethyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d] azepin-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(oxetan-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-2,2-dimethyl-2,3-dihydro-1-benzofuran-5-sulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-3-fluoro-4-methylbenzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(tetrahydrofuran-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(3R)-tetrahydrofuran-3-yloxy]benzenesulfonamide; \n 4-(trans-4-methoxycyclohexyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-(cis-1-fluoro-4-methoxycyclohexyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-(4,4-difluorotetrahydro-2H-pyran-2-yl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-((2R)-4,4-difluorotetrahydro-2H-pyran-2-yl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-((2S)-4,4-difluorotetrahydro-2H-pyran-2-yl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-3-fluoro-4-[(2S)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n N-[7-(3-fluoropropyl)-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl]-4-(propan-2-yl)benzenesulfonamide; \n 4-cyclohexyl-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-(cyclopentyloxy)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 6-[cyclopentyl(difluoro)methyl]-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 4-(trans-3-ethoxy-1-fluorocyclobutyl)-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-propyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(propan-2-yl)benzenesulfonamide; \n 4-ethoxy-N-(2-methoxy-7-propyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl) benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(propan-2-yl)benzenesulfonamide; \n 4-ethoxy-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl) benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-methylbenzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(propan-2-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[1-(trifluoromethyl)cyclopropyl]benzenesulfonamide; \n N-(7-ethyl-2-methoxy-5-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(propan-2-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(tetrahydro-2H-pyran-4-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-3,4-dihydro-2H-chromene-6-sulfonamide; \n 4-(difluoromethoxy)-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-6-phenoxypyridine-3-sulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-3,4-dimethyl benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-propylbenzenesulfonamide; \n 4-(cyclopentyloxy)-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-2,2-dimethyl-3,4-dihydro-2H-chromene-6-sulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-2,4-dimethylbenzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-2,4-dimethylbenzenesulfonamide; \n N-[7-ethyl-2-(propan-2-yloxy)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl]-3,4-dihydro-2H-chromene-6-sulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-2-methyl-2,3-dihydro-1-benzofuran-5-sulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(trans-3-methoxycyclobutyl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(4-methyltetrahydro-2H-pyran-4-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(tetrahydro-2H-pyran-2-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(tetrahydrofuran-3-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(cis-3-methoxycyclobutyl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-((2R)-tetrahydro-2H-pyran-2-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-((2S)-tetrahydro-2H-pyran-2-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(4-fluorotetrahydro-2H-pyran-4-yl)benzenesulfonamide; \n 4-(trans-3-methoxycyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(tetrahydro-2H-pyran-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(tetrahydro-2H-pyran-4-yloxy)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(4-methyltetrahydro-2H-pyran-4-yl)benzenesulfonamide; \n 4-(4-fluorotetrahydro-2H-pyran-4-yl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-(cis-3-methoxycyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(tetrahydrofuran-3-yloxy)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-((3R)-tetrahydro-2H-pyran-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-((3S)-tetrahydro-2H-pyran-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(trans-2-methyltetrahydro-2H-pyran-4-yl)benzenesulfonamide; \n 4-((4R)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-((4S)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(trans-2-methyltetrahydro-2H-pyran-4-yl)benzenesulfonamide; \n 4-[(1S)-1-methoxyethyl]-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-[(1R)-1-methoxyethyl]-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(3S)-tetrahydrofuran-3-yloxy]benzenesulfonamide; \n 4-(cis-4-methoxycyclohexyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-(trans-1-fluoro-4-methoxycyclohexyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(1-fluoro-4-methoxycyclohexyl)benzenesulfonamide; \n 4-(1-methoxycyclopentyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-(trans-1-fluoro-3-methoxycyclobutyl)benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-6-(tetrahydrofuran-3-yloxy)pyridine-3-sulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(2S)-tetrahydrofuran-2-yl]benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(2R)-tetrahydrofuran-2-yl]benzenesulfonamide; \n 6-(1-methoxycyclopentyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido [2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-6-(1-fluorocyclopentyl)pyridine-3-sulfonamide; \n 6-cyclopentyl-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 6-tert-butoxy-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-3-methyl-4-[(2R)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-3-methyl-4-[(2S)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n 4-(4-fluorotetrahydro-2H-pyran-2-yl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-3-methyl-4-[(2R)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n 4-(4-fluorotetrahydro-2H-pyran-2-yl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide, diastereomer-1; \n 4-(4-fluorotetrahydro-2H-pyran-2-yl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide, diastereomer-2; \n 3-fluoro-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(2R)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n 3-fluoro-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(2S)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-6-(1-fluorocyclohexyl)pyridine-3-sulfonamide; \n 6-cyclobutyl-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 6-cyclohexyl-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n N-[7-(3-fluoropropyl)-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl]-4-methylbenzenesulfonamide; \n 2-(cyclobutyloxy)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyrimidine-5-sulfonamide; \n 2-tert-butoxy-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyrimidine-5-sulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-propylbenzenesulfonamide; \n N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[cis-3-(2-fluoroethoxy)cyclobutyl]benzenesulfonamide; \n 4-(cis-3-ethoxycyclobutyl)-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-(trans-3-ethoxycyclobutyl)-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 6-(cyclopentyloxy)-N-[7-(3-fluoropropyl)-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl]pyridine-3-sulfonamide; \n 2-cyclopentyl-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyrimidine-5-sulfonamide; \n 6-(cyclopentyloxy)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-5-methylpyridine-3-sulfonamide; \n 6-(cyclopentyloxy)-N-(7-ethyl-2-methoxy-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-5-methylpyridine-3-sulfonamide; \n 6-(cyclobutyloxy)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-5-methylpyridine-3-sulfonamide; \n 2-cyclohexyl-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyrimidine-5-sulfonamide; \n 6-(cyclopentyloxy)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-2-methylpyridine-3-sulfonamide; \n N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-6-[(2R)-tetrahydro-2H-pyran-2-yl]pyridine-3-sulfonamide; \n 6-(cyclopentylmethyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 4-(trans-3-ethoxy-1-fluorocyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-[trans-1-fluoro-3-(2-fluoroethoxy)cyclobutyl]-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 6-(trans-3-ethoxycyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 6-(cis-3-ethoxycyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 6-(trans-1-fluoro-3-methylcyclobutyl)-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 6-(cyclopentyloxy)-5-fluoro-N-(2-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)pyridine-3-sulfonamide; \n 4-Ethoxy-N-(7-ethyl-2-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-chloro-N-(7-ethyl-2-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)benzenesulfonamide; \n 4-methyl-N-[7-methyl-2-(trifluoromethyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl]benzenesulfonamide; and \n N-(2-ethyl-7-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-3-yl)-4-[(2R)-tetrahydro-2H-pyran-2-yl]benzenesulfonamide; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 95.0
- Lexical Diversity: 1.72603
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12532715', '15423238', '11752683', '14157671', '12162851']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8030680595781655
- 35 USC 102 Novelty (BERT): 0.5296943212736634
- Combined Prediction Score: 0.7757306857477153
- Mean Citation Score: 336.6946460000001
- Max Citation Score: 341.11978
- Similarity Product: 261.6920469544649

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test