PATENT CLAIM ANALYSIS

Application Number: 16227820
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "343000"]

Abstract:
The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

Claim (Index 1):
A method for treating a cancer in a subject in need thereof, comprising administering to the subject a combination of:\n 1) an effective amount of a first agent selected from:\n i) crystalline 4-(5-Chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2 carboxylic acid [1-(3-chlorophenyl)-2-hydroxyethyl]amide, or \n ii) crystalline free base 4-(5-Chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1-(3-chlorophenyl)-2-hydroxyethyl]amide, or \n iii) crystalline 4-(5-Chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1-(3-chlorophenyl)-2-hydroxyethyl]amide mono HCl, or \n iv) crystalline 4-(5-Chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1-(3-chlorophenyl)-2-hydroxyethyl]amide HCl hydrate, or \n v) a crystalline compound of formula (I): \n \u2003having an X-ray powder diffraction (XRPD) pattern comprising characteristic peaks at about 9.1 15.4, 19.5 and 21.4\u00b0 2\u03b8, or vi) a crystalline hydrochloride salt of a compound of formula (I): \u2003having an X-ray powder diffraction (XRPD) pattern comprising characteristic peaks at about 6.7 11.0, 17.6 and 19.9\u00b0 2\u03b8, or vii) a pharmaceutical composition comprising at least one of i to vi, and 2) an effective amount of a second agent selected from the group consisting of an anaplastic lymphoma kinase (ALK) inhibitor, a B-Raf inhibitor, an epidermal growth factor (EGFR) inhibitor, an ERK inhibitor, a Janus kinase inhibitor, an MEK inhibitor, a mammalian target of rapamycin (mTOR) inhibitor, a phosphoinositide 3-kinase (PI3K) inhibitor, a RAS inhibitor, and combinations thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 98.0
- Lexical Diversity: 1.48276
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15011377', '15011420', '15598181', '15598160', '14821931']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.810266488157699
- 35 USC 102 Novelty (BERT): 0.5930529767508285
- Combined Prediction Score: 0.7885451370170119
- Mean Citation Score: 513.4798400000002
- Max Citation Score: 595.12555
- Similarity Product: 400.5099400617689

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test