PATENT CLAIM ANALYSIS

Application Number: 15879999
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-10
Patent Classification: ["514", "210210"]

Abstract:
The present application is concerned with heterocyclic compounds that inhibit the activity of Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancers and other diseases.

Claim (Index 45):
The method of  claim 32 , wherein the compound is selected from:\n N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(2-azabicyclo[2.2.1]heptan-2-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((2-fluorophenyl)(methyl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-((R)-2,4-dimethyl-5-oxopiperazin-1-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((R)-4-oxodihydro-1H-pyrido[1,2-a]pyrazin-2(6H,7H,8H,9H,9aH)-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(4-methoxyazepan-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(1,4-oxazepan-4-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(6-hydroxy-2-azaspiro[3.3]heptan-2-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(4-hydroxyazepan-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((R)-3-methylpiperidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(2-azaspiro[3.3]heptan-2-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((3S,4S)-3-fluoro-4-hydroxypiperidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(1,2-oxazinan-2-yl)quinoline-8-carboxamide; N-(4-((1R, 3 S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(dihydro-1H-furo[3,4-c]pyrrol-5 (3H, 6H,6aH)-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(3-methylazetidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-((S)-2, 4-dimethyl-3-oxopiperazin-1-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((S)-3- methylpiperidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(4-cyclopropyl-3- oxopiperazin-1-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(4-isopropyl-3-oxopiperazin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(3,3-dimethylazetidin-1-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(4-isobutyl-3-oxopiperazin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(3-methoxy-3-methylazetidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(2-methyl-6,7-dihydro-2H-pyrazolo [4,3-c]pyridin-5(4H)-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(5-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(7-oxa-2-azaspiro[3.5]nonan-2-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(3-ethoxyazetidin-1-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((S)-2-(hydroxymethyl)azetidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(4-(methylsulfonyl)-1,4-diazepan-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(2-fluorophenylamino)quinoline-8-carboxamide; Methyl 4-(8-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-ylcarbamoyl)-5-fluoroquinolin-3-yl)-1, 4-diazepane-1-carboxylate; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(1-methyl-4,5-dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(6-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(2-cyanophenylamino)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5\u2032-fluoro-3,4-dihydro-2H-1,3\u2032-biquinoline-8\u2032-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(4-methoxypiperidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(2-(hydroxymethyl)morpholino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(4-(2-methoxyethyl)-3-oxopiperazin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(4-methyl-3-oxo-1,4-diazepan-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(7-azabicyclo[2.2.1]heptan-7-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5\u2032,8-difluoro-3,4-dihydro-2H-1,3\u2032-biquinoline-8\u2032-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-(1,1-dioxidoisothiazolidin-2-yl)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-((3-(difluoromethoxy)pyridin-2-yl)(methyl)amino)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-((2-cyanocyclopentyl)(methyl)amino)-5-fluoroquinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-((2,6-dimethylpyridin-3-yl)(methyl)amino)-5-fluoroquinoline-8-carboxamide; -(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((3-fluoropyridin-2-yl)(methyl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(methyl(4-(trifluoromethyl)pyridin-3-yl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((6-methoxy-2-methylpyridin-3-yl)(methyl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((3-fluoropyridin-4-yl)(methyl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(methyl(4-methylpyridin-3-yl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(methyl(2-methylcyclobutyl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((4-methoxyphenyl)(methyl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(methyl(3-methylpyrazin-2-yl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((4-methoxypyridin-3-yl)(methyl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(methyl(tetrahydro-2H-pyran-3-yl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((2-methoxyphenyl)(methyl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(imidazo[1,2-c]pyridin-6-yl(methyl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(methyl((R)-tetrahydrofuran-3-yl)amino)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl}-5-fluoro-3-[(2S,4R)-4- methoxy-2-methylpyrrolidin-1-yl]quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((2R,4R)-4-methoxy-2-methylpyrrolidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((2S,4S)-4-methoxy-2-methylpyrrolidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((2R,4S)-4-methoxy-2-methylpyrrolidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((2R,4S)-4-methoxy-2-methylpiperidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((2S,4R)-4-methoxy-2-methylpiperidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((2R,4R)-4-methoxy-2-methylpiperidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((3R,4R)-3-fluoro-4-methoxypiperidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((3S,4S)-3-fluoro-4-(2-methoxyethoxy)piperidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl}-5-fluoro-3-[(2R,4S)-4-hydroxy-2-methylpyrrolidin-1-yl]quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((2S,4S)-4-hydroxy-2-methylpyrrolidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((S)-2-methylazetidin-1-yl)quinoline-8-carboxamide; N-(4-((1R,3S,5S)-3-Amino-5- methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((R)-2-methylazetidin-1-yl)quinoline-8-carboxamide; Ethyl 4-(8-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-ylcarbamoyl)-5-fluoroquinolin-3-yl)piperazine-1-carboxylate; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((R)-2-methylpiperidin-1-yl)quinoline-8-carboxamide; and N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((S)-2-methylpiperidin-1-yl)quinoline-8-carboxamide; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 1.34483
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14465910', '15001826', '14155134', '14798137', '15166380']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8280945721106638
- 35 USC 102 Novelty (BERT): 0.5468971471985655
- Combined Prediction Score: 0.799974829619454
- Mean Citation Score: 403.687508
- Max Citation Score: 408.53394
- Similarity Product: 322.3496805861103

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test