PATENT CLAIM ANALYSIS

Application Number: 16067444
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["544", "326000"]

Abstract:
Disclosed in the present invention are an acrylanilide compound represented by general formula (I) and a pharmaceutically acceptable salt thereof. The acrylanilide compound and the pharmaceutically acceptable salt thereof are used for treating clinical diseases by mainly acting on EGFR family casein kinases.

Claim (Index 12):
The compound or the pharmaceutically acceptable salts, solvates or prodrugs thereof according to  claim 1 , wherein the compound is selected from the group consisting of:\n N-(5-(4-(3-bromophenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chlorophenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-fluorophenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-trifluoromethylphenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-methylphenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methylphenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methylphenylthio)-pyrimidin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-acetenylphenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-phenoxylphenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(phenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-methoxyphenoxy)-pyrimidin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(3-(4-(3-chloro-4-fluoro-phenylamino)-pyrimidin-2-ylamino)-4-methoxyl-phenyl)-acrylamide N-(5-(4-(3-chlorine-4-fluorophenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chlorine-2-fluorophenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3,4-dichloro-2-fluorophenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(2,4-dichloro-5-methoxyphenylamino)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-dimethylamino-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxyl)-phenylamino)-pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(5-chloro-4-(3-chloro-4-(pyridin-2-ylmethoxyl)-phenylamino)-pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-(4-morpholine-4-yl)-piperidine-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-(4-(4-methylpiperazin-1-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-(4-(1-methylpiperidin-4-yl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-(4-methyl piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-(4-(2-hydroxyethyl)piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-(4-methyl-[1,4]diazepin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-(4-(piperidin-1-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-(4-acetylpiperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-2-ylamino)-2-(4-(dimethylamino)piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(-4-(3-chloro-4-(benzene-2-methoxyl)-phenylamino)-pyrimidin-2-ylamino)-2-(2-(morpholin-4-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyl-phenyl)-acrylamide; N-(2-((2-(dimethylamino-ethyl)-methyl-amino)-5-(4-(indolin-1-yl)-pyrimidin-2-ylamino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-4-methoxyl-2-(4-acetyl-piperazin-1-yl)-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-4-methoxyl-2-(4-(4-methyl-piperazin-1-yl)-piperidin-1-yl)-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-4-methoxyl-2-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(cyclohexylmethyl)-piperazin-1-yl)-4-methoxylphenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-amino)-4-methoxyl-2-(4-methyl-1,4-diazepin-1-yl)-phenyl)-acrylamide; N-(2-(1,4\u2032-bipiperidin-1\u2032-yl-)-5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-dimethylamino-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(2-methoxylethyl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-pyrrolidyl-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(2-cyanoethyl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-tert-butylpiperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-4-methoxyl-2-(4-(2-(pyridin-4-yl)-ethyl)-piperazin-1-yl)-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-benzylpiperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(benzo[d][1,3]dioxy-5-methyl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(2-hydroxypropyl-2-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(hydroxymethyl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-isobutylpiperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(morpholin-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-dimethylamino)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-pyrrolidin-1-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-4-methyl-piperazin-1-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-{2-[(2-dimethylamino)-ethyl)-methyl-amino]-4-methoxyl-5-[4-(6-methoxyl-indol-1-yl)-pyrimidin-2-ylamino]-phenyl}-acrylamide; N-{2-[(2-dimethylamino)-ethyl)-methyl-amino]-4-methoxyl-5-[4-(6-methyl-indol-1-yl)-pyrimidin-2-ylamino]-phenyl}-acrylamide; N-{5-[4-(6-cyano-indol-1-yl)-pyrimidin-2-ylamino]-2-[(2-dimethylamino-ethyl)-methyl-amino]-4-methoxyl-phenyl}-acrylamide; N-(5-(4-(6-chloro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-((2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-bromo-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(dimethylamino)-piperidinyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(dimethylamino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(4-methylpiperazin-1-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(1-methylpiperidin-4-yl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(morpholin-4-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(2-hydroxyl-ethyl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-methyl-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-acetyl-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-methyl-[1,4]diazepin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(piperidin-1-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-4-acryloyl-piperazin-1-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(morpholin-4-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-pyrrolidin-1-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-methyl-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-methoxyl-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; 2-((2-acrylamido-5-methoxyl-4-(4-(5-methoxyl-1H-indol-1-yl)-pyrimidin-2-yl)-amino)-phenyl)-methyl-N,N-dimethyl-N-ethylamine oxide; N-(5-(4-(5-chloro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-bromo-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-trifluoromethyl-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-((2-(dimethylamino-ethyl-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-acetyl-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl-)-pyrimidin-2-ylamino)-2-(4-(piperidin-4-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(cyclohexylmethyl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-methyl-[1,4]diazepin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(dimethylamino methyl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(morpholin-4-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(4-methylpiperazin-1-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-methyl-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(1-methylpiperidin-4-yl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(2-hydroxyl-ethyl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(2-(2-hydroxyethoxyl)-ethyl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(dimethylamino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(morpholin-4-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-pyrrolidin-1-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methyl-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methoxyl-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-cyano-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-chloro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5,6-difluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-fluoro-6-chloro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-{5-[4-(6-chloro-5-fluoro-indol-1-yl)-pyrimidin-2-ylamino]-2-[(2-dimethylamino-ethyl)-methyl-amino]-4-propoxyl-phenyl}-acrylamide; N-(5-(4-benzotriazol-1-yl-pyrimidin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-phenylamino)-[1,3,5]triazin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-fluoro-phenylamino)-[1,3,5]triazin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-2-fluoro-phenylamino)-[1,3,5]triazin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-[1,3,5]triazin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-chloro-4-(3-fluorophenylmethoxy)-phenylamino)-[1,3,5]triazin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-trifluoromethyl-phenylamino)-[1,3,5]triazin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-fluoro-phenylamino)-[1,3,5]triazin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-[5-[4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino]-2-(3-dimethylamino-pyrrolidin-1-yl)-4-methoxyl-phenyl]-acrylamide; N-[5-[4-(3-bromo-phenylamino)-[1,3,5]triazin-2-amino]-2-(4-dimethylamino-piperidin-1-yl)-4-methoxyl-phenyl]-acrylamide; N-[5-[4-(3-bromo-phenylamino)-[1,3,5]triazin-2-amino]-4-methoxyl-2-(4-(pyrrolidin-1-yl-piperidin-1-yl)-phenyl-acrylamide; N-{2-[1,4\u2032]-piperidinylpiperidin-1\u2032-yl-5-[4-(3-bromo-phenylamino)-[1,3,5]triazin-2-amino]-4-methoxyl-phenyl}-acrylamide; N-(5-(4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-4-methoxyl-2-(4-(4-methyl-piperazin-1-yl)-piperidin-1-yl)-phenyl)-acrylamide; N-(5-(4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-2-(4-ethyl-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-2-(4-tert-butyl-piperazin-1-yl)-4-methoxyl-phenylamino)-acrylamide; N-(5-(4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-2-(4-(3-dimethylamino-propyl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-4-methoxyl-2-(4-(1-methylpiperidin-4-yl)-piperazin-1-yl)-phenyl)-acrylamide; N-{5-[4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino]-2-[4-(2-cyano-ethyl)-piperazin-1-yl]-4-methoxyl-phenyl}-acrylamide; N-{5-[4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino]-2-[4-(2-hydroxyl-ethyl)-piperazin-1-yl]-4-methoxyl-phenyl}-acrylamide; N-{5-[4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-4-methoxyl-2-(4-(2-methoxyl-ethyl)-piperazin-1-yl)-phenyl]-acrylamide; N-(5-(4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-2-(4-cyclohexyl-methyl-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(2-(4-acetyl-piperazin-1-yl)-5-(4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino)-4-methoxyl-2-(4-methyl-[1,4]diazepan-1-yl)-phenyl)-acrylamide; N-[5-[4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino]-4-methoxyl-2-(2-morpholin-4-yl-ethoxyl)-phenyl]-acrylamide; N-[5-[4-(3-bromo-phenylamino)-[1,3,5]triazin-2-ylamino]-4-methoxyl-2-(2-methoxyl-ethoxyl)-phenyl]-acrylamide; N-(5-(6-(3-bromo-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(2-((2-dimethylamino)-ethyl)-methyl-amino)-4-methoxyl-5-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(5-(6-(3-alkynyl-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2-fluoro-3,4-dichloro-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2-fluoro-3-chloro-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-bromo-5-fluoro-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-2-methyl-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-2-[piperidin-1-yl]-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-4-methoxyl-2-(4-morpholin-4-yl-piperidin-1-yl)-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-2-(4-methyl-[1,4]diazepin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-4-methoxyl-2-(4-methyl-piperazin-1-yl)-phenyl)-acrylamide; N-(2-(4-acetyl-piperazin-1-yl)-5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-4-methoxyl-2-(4-(1-methylpiperidin-4-yl)-piperazin-1-yl)-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-2-(2-dimethylamino-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-4-methoxyl-2-(2-pyrrolidin-1-yl-ethoxyl)-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-2-(2-(4-methyl-piperazin-1 yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-4-methoxyl-2-(2-morpholin-4-yl-ethoxyl)-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-fluoro-phenylamino)-pyrimidin-4-ylamino)-2-(2-methoxylethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-(3-fluoro-benzyloxy)-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-benzimidazol-1-yl-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-benzotriazol-1-yl-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-(4-methylpiperazin-1-yl)-phenyl)-acrylamide; N-(2-(4-ethyl-piperazin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(2-(4-tert-butyl-piperazin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-(4-(1-methylpiperidin-4-yl)-piperazin-1-yl)-phenyl)-acrylamide; N-(2-(4-(2-hydroxyl-ethyl)-piperazin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(4-methoxyl-2-(4-(2-methoxyl-ethyl)-piperazin-1-yl)-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(2-(4-(2-(2-hydroxyl-ethoxyl)-ethyl)-piperazin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-(4-(2-(pyrrolidin-1-yl)-ethyl)-piperazin-1-yl)-phenyl)-acrylamide; N-(2-(4-(2-(dimethylamino)-ethyl)-piperazin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(2-(4-acetylpiperazin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-(4-phenylpiperazin-1-yl)-phenyl)-acrylamide; N-(2-(4-benzylpiperazin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-(4-(-(pyrimidin-3-ylmethyl)-piperazin-1-yl)-phenyl)-acrylamide; N-(4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-(4-methyl-2-phenylpiperazin-1-yl)-phenyl)-acrylamide; N-(2-(4-(bis-(4fluoro-phenyl)-methyl)-piperazin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(4-methoxyl-2-(4-methyl-[1,4]diazepin-1-yl)-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; (S)\u2014N-(2-(3-dimethylamino-pyrrolidin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(2-(4-dimethylamino-piperidin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-(4-(4-methylpiperazin-1-yl)-piperidin-1-yl)-phenyl)-acrylamide; N-(2-(4-(morpholin-4-yl)piperidin-1-yl)-4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(4-methoxyl-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-(methyl-(2-pyrrolidin-1-yl-ethyl)-amino)-phenyl)-acrylamide; N-(5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-2-ylamino)-2-((2-(dimethylamino)-ethyl-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-5-[6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino]-4-propyl-phenyl}-acrylamide; N-{2-((2-dimethylamino-ethyl)-methylamino)-5-[6-(1-ethyl-1H-indol-3-yl)-pyrimidin-4-ylamino]-4-methoxyl-phenyl}-acrylamide; N-{2-[(2-dimethylamino-ethyl)-methylamino]-5-[6-(1-propyl-1H-indol-3-yl)-pyrimidin-4-ylamino]-4-methoxyl-phenyl}-acrylamide; N-{2-[(2-dimethylamino-ethyl)-methylamino]-5-[6-(1-isopropyl-1H-indol-3-yl)-pyrimidin-4-ylamino]-4-methoxyl-phenyl}-acrylamide; N-{2-[(2-dimethylamino-ethyl)-methylamino]-5-[6-(1-isopropyl-1H-indol-3-yl)-pyrimidin-4-ylamino]-4-propoxyl-phenyl}-acrylamide; N-(5-(6-(1-benzyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(4-methoxyl-5-(6-(6-fluoro-1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-phenyl)-acrylamide; N-(2-((2-dimethylamino-ethyl)-methyl-amino)-5-(4-(5-fluoro-indol-1-yl)-pyrimidin-2-ylamino)-4-propyl-phenyl)-acrylamide; N-(2-((2-dimethylamino-ethyl)-methylamino)-5-(6-(5-fluoro-1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-4-methoxyl-phenyl)-acrylamide; N-(5-[6-(5-fluoro-1-isopropyl-1H-indol-3-yl)-pyrimidin-4-ylamino]-2-{[2-(1-oxy-pyrrolidin-1-yl)-ethyl]-methyl-amino}-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(5-fluoro-1-isopropyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-4-methoxy-2-(4-(4-methyl-piperazin-1-yl)-piperidin-1-yl)-phenyl)-acrylamide; N-(5-(6-(5-fluoro-1-isopropyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-4-methoxyl-2-((2-dimethylamino-ethyl)-methyl-amino)-phenyl)-acrylamide; 2-((2-acrylamido-5-methoxyl-4-((6-(1-isopropyl-5-fluoro-1H-indol-3-yl)-pyrimidin-4-yl)-amino)-phenyl)-methyl)-N,N-dimethyl-N-ethylamine oxide; N-(5-(6-(5-fluoro-1-cyclopentyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-4-methoxyl-2-((2-dimethylamino-ethyl)-methylamino)-phenyl)-acrylamide; N-(2-((2-(dimethylamino)-ethyl)-methylamino)-4-methoxyl-5-(2-methyl-6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-yl-amino)-phenyl)-acrylamide; N-(5-(5-methyl-6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-4-methoxyl-2-((2-dimethylamino-ethyl)-methyl-amino)-phenyl)-acrylamide; N-(4-methoxyl-2-(2-methoxyl-ethoxyl)-5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-phenyl)-acrylamide; N-(5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-4-methoxy-2-(2-(4-methylpiperazin-1-yl)-ethoxyl)-phenyl)-acrylamide; N-(5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-4-methoxy-2-(2-(morpholin-4-yl)-ethoxyl)-phenyl)-acrylamide; N-(5-(6-(1-methyl-1H-indol-3-yl)-pyrimidin-4-ylamino)-4-methoxy-2-(2-(pyrrolidin-1-yl)-ethoxyl)-phenyl)-acrylamide; N-(5-(4-((3-chloro-4-(pyridin-2-methoxyl)phenyl)-methyl-amino)-pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(5-chloro-4-(3-chloro-4-(pyridin-2-methoxyl)phenoxyl)pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methoxyl-1H-indol-1-yl)-5-trifluoromethyl-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methoxyl-1H-indol-1-yl)-5-chloro-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-hydroxyl-1H-indol-1-yl)-5-chloro-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-(2-methoxyl-ethoxyl)-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-n-hexyloxy-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(5-(2-methoxyl-ethoxyl)-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methoxyl-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(4-(4-methyl-piperazin-1-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(6-(2-methoxyl-ethoxyl)-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-((tetrahydrofuran-2-yl)-methoxyl)-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methoxyl-6-bromo-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methoxyl-6-fluoro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-methoxyl-6-chloro-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(4-(4-(2,5-dimethylpyrrol-1-yl)-6-bromo-1H-indol-1-yl)-pyrimidin-2-ylamino)-2-(2-(dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-(2-morpholin-4-yl-ethoxyl)-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylaminoethyl)-methyl-amino)-4-methoxyphenyl)-acrylamide; N-(5-(6-(3-chloro-4-(tetrahydropyran-4-yl-methoxyl)-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylaminoethyl)-methyl-amino)-4-methoxyphenyl)-acrylamide; N-(5-(6-(3-(1-(3-methylbutoxy)ethyl)-4-methoxylphenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylaminoethyl)-methyl-amino)-4-methoxylphenylamino)-acrylamide; N-(5-(6-(3-chloro-4-methoxyl-phenylamino)-pyrimidin-4-ylamino)-2-(2-dimethylamino-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-(3-methylbutoxy)-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylaminoethyl)-methyl-amino)-4-methoxyphenyl)-acrylamide; 5-(6-(5-acrylamido-4-((2-methoxyphenyl)-methyl-amino)-2-methoxylphenylamino)-pyrimidin-4-yl)-2-methoxybenzamide; 5-(6-(5-acrylamido-4-((2-methoxyphenyl)-methyl-amino)-2-methoxylphenylamino)-pyrimidin-4-yl)-2-methoxyl-N-methylbenzamide; N-(5-(6-(4-methoxyl-3-trifluoromethyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-(thiazol-2-ylmethoxy)-phenylamino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(4-methoxyl-3-bromo-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(4-methoxyl-3-chloro-phenylamino)-pyrimidin-4-yl-amino)-2-(2-(pyrrolidin-1-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(4-fluoro-3-trifluoromethyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-methoxyl-phenylamino)-pyrimidin-4-ylamino)-2-(4-(1-methylpiperidin-4-yl)-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(4-chloro-3-trifluoromethyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-cyano-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(5-fluoro-3-trifluoromethyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2-fluoro-5-trifluoromethyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-methoxyl-5-trifluoromethyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2-methoxyl-5-trifluoromethyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-trifluoromethyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-trifluoromethoxy-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-5-fluoro-4-(2-methoxyl-ethoxyl)-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-methanesulfonamido-4-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(4-methyl-piperazin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(4-(morpholin-1-yl)-piperidin-1-yl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(methyl-(2-(4-methyl-piperazin-1-yl)-2-oxoethyl)-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-ylamino)-2-(2-dimethylamino-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(2-(morpholin-4-yl)-ethoxyl-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(2-(pyrrolidin-1-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(2-(4-methyl-piperazin-1-yl)-ethoxyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(3-(pyrrolidin-1-yl)-propyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(2-(piperidin-1-yl)-ethoxyl-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(3-(4-methyl-piperazin-1-yl)-propyl)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-((2,4-dichloro-5-methoxyl-phenyl)-methyl-amino)-pyrimidin-4-ylamino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(2,4-dichloro-5-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-(3-(morpholin-4-yl)-propoxyl-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-tert-butoxy-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-acetenyl-4-methoxyl-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide; N-(5-(6-(3-chloro-4-(3-methyl-oxetan-3-yl-methoxyl)-phenylamino)-pyrimidin-4-yl-amino)-2-((2-dimethylamino-ethyl)-methyl-amino)-4-methoxyl-phenyl)-acrylamide.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 1.30556
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11728897', '15745187', '12865339', '12755301', '13386645']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8560120309564513
- 35 USC 102 Novelty (BERT): 0.5529751833410895
- Combined Prediction Score: 0.8257083461949151
- Mean Citation Score: 420.294502
- Max Citation Score: 433.8232
- Similarity Product: 338.6146493405342

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- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test