PATENT CLAIM ANALYSIS

Application Number: 16064084
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["549", "060000"]

Abstract:
The present invention relates to an improved crystallization procedure to obtain canagliflozin hemihydrate crystals having a narrow particle size distribution by removing a small part of the crystalline suspension in the crystallization vessel from said vessel and subjecting said part to particle size reduction of the formed crystals followed by heating and reintroducting said part of the crystalline suspension again in the crystallization vessel which is kept within a specific temperature range.

Claim (Index 1):
A process for preparing canagliflozin hemihydrate crystals comprising the consecutive steps of\n a) preparing a solution in a crystallization vessel of canagliflozin in a solvent system comprising water in an amount from 0.37 wt % to 1.50 wt % under concentration and temperature conditions which allow the complete dissolution of canagliflozin; b) cooling the said solution to a temperature such that crystallization will start upon addition of a seed crystal; c) seeding the solution of step b) with crystalline canagliflozin hemihydrate; d) cooling the solution of step c) to a temperature ranging from 35\u00b0 C. to 47\u00b0 C. in order to obtain a crystalline suspension; e) removing a part of the crystalline suspension from the crystallization vessel in an amount that is less than the entire content and subjecting said part to particle size reduction, heating said part to a temperature higher than the temperature of the crystalline suspension in the crystallization vessel and returning said part back to the crystallization vessel; f) repeating step e) until the entire content of the crystallization vessel has undergone between 0.8 and 100 turnovers; g) isolating the crystals of crystalline canagliflozin hemihydrate thus formed.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 94.0
- Lexical Diversity: 1.55319
- Patent Class: 549.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15115440', '14888961', '15776794', '15291202', '15759562']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7033089640172934
- 35 USC 102 Novelty (BERT): 0.4863641489541385
- Combined Prediction Score: 0.6816144825109779
- Mean Citation Score: 191.759966
- Max Citation Score: 223.94632
- Similarity Product: 174.1738533499241

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test