PATENT CLAIM ANALYSIS

Application Number: 15944432
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["514", "553000"]

Abstract:
The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.

Claim (Index 12):
A method of treating a subject with a urea cycle disorder (UCD) who has a fasting plasma ammonia level less than the upper limit of normal and who is not experiencing a hyperammonemic crisis, the method comprising:\n a) orally administering an initial dosage of glyceryl tri[4-phenylbutyrate]; b) after a time period sufficient for the glyceryl tri-[4-phenylbutyrate] to reach steady state, measuring a single fasting plasma ammonia level for the subject and not serial blood draws; c) comparing the fasting plasma ammonia level to the upper limit of normal, wherein the upper limit of normal is relative to the reference range of normal values at the laboratory in which the ammonia was measured; d) orally administering an adjusted dosage of glyceryl tri-[4-phenylbutyrate], wherein the adjusted dosage is greater than the initial dosage if the fasting plasma ammonia level is greater than half the upper limit of normal for plasma ammonia level, e) monitoring the subject for headache, somnolence, nausea, and/or vomiting; and f) if the subject experiences headache, somnolence, nausea, and/or vomiting, orally administering a reduced dosage of glyceryl tri-[4-phenylbutyrate] to the subject, wherein a subject with a fasting ammonia in the range 0-0.5 ULN has a greater than 80% likelihood of having an average daily ammonia level within a normal range.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 91.0
- Lexical Diversity: 1.29268
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15687132', '15457643', '15944411', '15944416', '15944428']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7986760525497483
- 35 USC 102 Novelty (BERT): 0.6553330798100516
- Combined Prediction Score: 0.7843417552757787
- Mean Citation Score: 622.139638
- Max Citation Score: 623.1339
- Similarity Product: 614.2466400641441

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test