PATENT CLAIM ANALYSIS

Application Number: 15953428
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["540", "469000"]

Abstract:
The invention relates to pyrridinobenzodiazepines (PDDs) comprising three fused 6-7-6-membered rings linked to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, such as anti-proliferative agents. PDDs may be represented by formula (I): and salts and solvates thereof, wherein the dotted lines indicates the optional presence of a double bond between one or more of C1 and C2, C2 and C3, and C3 and C4; R1 and R2 are substituent groups; R3 is selected from H, C1-12 alkyl and CH2Ph; R4 is selected from phenyl and Cs-9heteroaryl groups optionally substituted, with the proviso that the optionally substituted C 5-9  heteroaryl is not indolyl; R19 is selected from H and (CH2)t-NR2oR21; Y1 is N or CH; Y2 is N or CH; and wherein at least one of Y1 and Y2 is CH; p is 0 or 1; X1 is a connecting group; L is a linker group; X2 is a connecting group or is absent; q is selected from 0, 1, 2, 3, 4, 5 and 6; A is selected from: for each A1 group one of Y3 and Y4 is selected from N-R17, S and O; and the other of Y3 and Y4 is CH; and Y5 is selected from CH, N, S and COH; for each A2 group one of Y6 and Y7 is independently selected from N and CH; and the other of Y6 and Y7 is CH; R13, R14, R17, R20 and R21 are independently selected from H and C1-6 alkyl; and either: (i) R5 and R6 together form a double bond; (ii) R5 is H and R6 is OH; or (iii) R is H and R6 is OC1-6 alkyl; with the proviso that when p is  0  and A is A 1 , then: (a) for at least one A1 group one of Y Sand Y4 is selected from S and O; or (b) for at least one A1 group Y5 is S; or (c) R4 is not pyrrolyl, imidazolyl, optionally substituted pyrrolyl or optionally substituted imidazolyl.

Claim (Index 5):
The compound, salt or solvate of  claim 2 , wherein R 2  is H.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 91.0
- Lexical Diversity: 2.71141
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16061295', '15579148', '15135352', '14604129', '14238415']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6998509418767517
- 35 USC 102 Novelty (BERT): 0.5702790513590116
- Combined Prediction Score: 0.6868937528249777
- Mean Citation Score: 375.996744
- Max Citation Score: 431.64725
- Similarity Product: 383.4732893235087

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test