PATENT CLAIM ANALYSIS

Application Number: 16031418
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["424", "141100"]

Abstract:
The present invention is directed to an anti-prion monoclonal antibody and its use for the treatment of conditions associated with or mediated by proteins or peptides having a toxic oligomeric form. These conditions include, but are not limited to, Alzheimer's disease, frontotemporal dementias, traumatic brain injury, and chronic traumatic encephalopathy.

Claim (Index 1):
An antibody or binding fragment thereof that binds prion protein, said antibody or binding fragment thereof comprising a heavy chain variable region, wherein said heavy chain variable region comprises:\n a complementarity-determining region 1 (H-CDR1) comprising an amino acid sequence of SEQ ID NO: 1, or a modified amino acid sequence of SEQ ID NO: 1, said modified sequence containing 1 or 2 amino acid residue modifications as compared to SEQ ID NO: 1; a complementarity-determining region 2 (H-CDR2) comprising an amino acid sequence of SEQ ID NO: 2, or a modified amino acid sequence of SEQ ID NO: 2, said modified sequence containing 1, 2, 3, or 4 amino acid residue modifications as compared to SEQ ID NO: 2; and a complementarity-determining region 3 (H-CDR3) comprising an amino acid sequence of SEQ ID NO: 3, or a modified amino acid sequence of SEQ ID NO: 3, said modified sequence containing 1, 2, or 3 amino acid residue modifications as compared to SEQ ID NO: 3.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 95.0
- Lexical Diversity: 1.20833
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13773264', '12999045', '14616300', '15324141', '14407724']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7041066177893357
- 35 USC 102 Novelty (BERT): 0.5380893837752706
- Combined Prediction Score: 0.6875048943879293
- Mean Citation Score: 357.33605400000016
- Max Citation Score: 366.13882
- Similarity Product: 273.54488599755285

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test