PATENT CLAIM ANALYSIS

Application Number: 15772910
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["540", "467000"]

Abstract:
The present invention provides compositions and methods for providing controllable local delivery of a conjugate of bortezomib (Btz) and a bisphosphonate to promote bone formation. In certain embodiments, the invention is used as a treatment for a subject with diseases and disorders characterized by bone loss.

Claim (Index 3):
The compound of  claim 1 , wherein the compound of formula (I) is a compound of formula (III): wherein in formula (III):\n each occurrence of R 1  is independently selected from the group consisting of hydrogen and alkyl; \n R 2  is selected from the group consisting of hydrogen, alkyl, \u2014OR 13 , \u2014N(R 13 )(R 14 ), and halogen; \n Y is selected from the group consisting of \u2014PO(OR 8 )(OR 9 ), \u2014PO(R 9 )(OR 8 ), \u2014CO 2 R 8 , and \u2014SO 3 R 8 ; \n Z 1  is selected from the group consisting of CH 2  and NR 6 ; \n A is selected from the group consisting of CH 2 , C(\u2550O), C(\u2550NR 7 ), and C(\u2550S); \n Z 2  is selected from the group consisting of CH 2 , NR 11 , S, and O; \n Z 4  is selected from the group consisting of CH 2  and O; \n L 1  is selected from the group consisting of alkyl, aryl, cycloalkyl, alkylaryl, alkylcycloalkyl, wherein the alkyl, aryl, cycloalkyl, alkylaryl, or alkylcycloalkyl group is optionally substituted with one to four substituents selected from the group consisting of hydroxyl, alkoxy, alkenyl, cycloalkyl, aryl, heteroaryl, halo, cyano and amino; \n R 6  and R 7  are each independently selected from the group consisting of hydrogen and alkyl, wherein the alkyl group is optionally substituted with one to four substituents selected from the group consisting of hydroxyl, alkoxy, alkenyl, cycloalkyl, aryl, heteroaryl, halo, cyano and amino; \n R 8 , R 9 , and R 10  are each independently selected from the group consisting of hydrogen and alkyl; \n R 11 , R 13 , and R 14  are each independently selected from the group consisting of hydrogen and alkyl, wherein the alkyl group is optionally substituted with one to four substituents selected from the group consisting of hydroxyl, alkoxy, alkenyl, cycloalkyl, aryl, heteroaryl, halo, cyano and amino; and \n m is an integer from 1 to 5; \n n is an integer from 0 to 10; \n p is an integer from 1 to 5; and \n x is an integer from 0 to 10; or \n a pharmaceutically acceptable salt thereof, an isomer thereof, or a mixture of isomers thereof.

Metadata:
- Claim Count in Document: 33.0
- Percentile: 93.0
- Lexical Diversity: 1.2439
- Patent Class: 540.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15772893', '15094733', '14378089', '10576228', '15951585']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7420902286654472
- 35 USC 102 Novelty (BERT): 0.5328239414169287
- Combined Prediction Score: 0.7211635999405953
- Mean Citation Score: 295.387648
- Max Citation Score: 362.4084
- Similarity Product: 329.713219460392

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test