PATENT CLAIM ANALYSIS

Application Number: 16087861
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["514", "210210"]

Abstract:
Disclosed is a new indole compound, in particular, the compound as shown in formula (I), and a preparation method, pharmaceutical composition and use thereof as an estrogen receptor down-regulator in preparing drugs for treating estrogen receptor-positive breast cancer.

Claim (Index 1):
A compound represented by formula (I), a pharmaceutically acceptable salt, a hydrate or a prodrug thereof, wherein, R 1  is selected from X is selected from single bond, O and S; Y and Z are each independently selected from N and CH; ring A is selected from 5-10 membered aryl and 5-10 membered heteroaryl; R 2  is selected from H, halogen, CN, NO 2 , OH, COOH, NH 2 , or the group consisting of C 1-6  alkyl, C 1-6  heteroalkyl, C 3-6  cycloalkyl and 3-6 membered heterocycloalkyl, each of which is optionally substituted with 1, 2, or 3 R; R 3  is selected from H, halogen, CN, NO 2 , OH, COOH, NH 2 , or the group consisting of C 1-6  alkyl, C 1-6  heteroalkyl, C 3-6  cycloalkyl and 3-6 membered heterocycloalkyl, each of which is optionally substituted with 1, 2, or 3 R; R 4  and R 5  are each independently selected from H, halogen, CN, NO 2 , OH, COOH, NH 2 , or the group consisting of C 1-6  alkyl, C 1-6  heteroalkyl, C 3-6  cycloalkyl and 3-6 membered heterocycloalkyl, each of which is optionally substituted with 1, 2, or 3 R; R 6  is selected from the group consisting of C 1-6  alkyl, C 1-6  heteroalkyl, C 3-6  cycloalkyl and 3-6 membered heterocycloalkyl, each of which is optionally substituted with 1, 2, or 3 R; R is selected from H, F, Cl, Br, I, OH, CN, NH 2 , COOH, C(\u2550O)NH 2 , or the group consisting of C 1-8  alkyl, C 1-8  heteroalkyl, C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl and C 3-6  cycloalkyl-C 1-3  alkyl-, each of which is optionally substituted with 1, 2, or 3 R\u2032; n is selected from 0, 1, 2, 3 and 4; m is selected from 0, 1, 2, 3 and 4; P is selected from 0, 1, 2 and 3; or, when m is 2, R 3  and R 3  are connected together to form a 5-6 membered ring; R\u2032 is selected from the group consisting of F, Cl, Br, I, OH, CN, NH 2 , COOH, Me, Et, CF 3 , CHF 2 , CH 2 F, NHCH 3  and N(CH 3 ) 2 ; \u201chetero\u201d represents a heteroatom or a heteroatom group, which is selected from the group consisting of \u2014C(\u2550O)N(R)\u2014, \u2014N(R)\u2014, \u2014S(\u2550O) 2  N(R)\u2014, \u2014S(\u2550O) N(R)\u2014, \u2014O\u2014, \u2014S\u2014, \u2550O, \u2550S, \u2014O\u2014N\u2550, \u2014C(\u2550O)O\u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 \u2014 and \u2014N(R)C(\u2550O)N(R)\u2014; in any of the above cases, the number of the heteroatom or the heteroatom group is independently selected from 1, 2 and 3.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 97.0
- Lexical Diversity: 1.28571
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16343387', '10465426', '10420399', '11585598', '12245305']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8447229243990073
- 35 USC 102 Novelty (BERT): 0.5506661017948372
- Combined Prediction Score: 0.8153172421385904
- Mean Citation Score: 398.579302
- Max Citation Score: 429.7016
- Similarity Product: 313.832571100235

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test