PATENT CLAIM ANALYSIS

Application Number: 15774395
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-09
Patent Classification: ["424", "452000"]

Abstract:
The present invention relates to a gastric retention active delivery system in the form of a coated capsule, which, in contrast to prior art delivery systems exhibiting relatively poor floating-properties, and thus requiring size expansion capability in order to securely delay passage through the pylorus, reliably stay afloat for several hours. This is achieved by combining pore forming components and flexible polymer components in the coating in suitable proportions. The present invention, further, relates to the use of gastric retention active delivery systems of the invention for the delivery of one or more water soluble active components A to a mammal.

Claim (Index 2):
The gastric retention active delivery system according to  claim 1 , comprising the sealed capsule encasing the effervescent formulation comprising the at least one water soluble active component A, and a coating comprising an initial dose ID of the at least one water soluble active component A present within the sealed capsule, wherein:\n the coating comprises:\n a total amount px of the at least pore forming component P, in which the total amount px satisfies:\n p 1< px<p 2, \n \n where p1=1 mg/cm 2  and p2=11 mg/cm 2 ;\n a total amount fx of the at least one flexible polymer component F, in which the total amount fx satisfies:\n f 1< fx<f 2, \n \n where f1=4 mg/cm 2  and f2=10 mg/cm 2 , and wherein the total amount px and the total amount fx satisfy:\n 0.453* px+ 3.49 mg/cm 2 <fx< 0.625* px+ 4.75 mg/cm 2 ; \n a total amount ex of the at least one amphiphilic emulsifier component E, in which the total amount ex satisfies:\n e 1< ex<e 2, \n \n where e1=0 and e2=0.1*fx;\n a total amount tx of the at least one anti-tacking component T, in which the total amount tx satisfies:\n t 1< tx<t 2, \n \n where t1=0.5*fx and t2=2*fx; and\n a total amount nx of the at least one non-water soluble excipient N, in which the total amount nx satisfies:\n n 1< nx<n 2, \n \n where n1=0 and n2=0.1*fx;\n the flexible polymer component F is defined as a neutral or virtually neutral (meth)acrylate copolymer comprising 20 wt % to 40 wt % of ethyl acrylate, 60 wt % to 80 wt % of methyl methacrylate and 0 to less than 5 wt % methacrylic acid or acrylic acid; \n the pore forming component P is defined as a water soluble substance comprising the at least one active component A, but excluding the amphiphilic emulsifier component E; \n the initial dose ID of the at least one water soluble active component A present in the coating constitutes 5 wt % to 50 wt % of the total amount of the at least one water soluble active component A present in the gastric retention active delivery system; and \n the effervescent formulation inside of the sealed capsule exhibits a gas generating capacity ranging from 60 Vol % to 140 Vol % of the total volume of the sealed capsule at 25\u00b0 C. and 1013 mbar.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 93.0
- Lexical Diversity: 1.61765
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['10492690', '12374383', '14255529', '14230053', '14398005']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6390822747793204
- 35 USC 102 Novelty (BERT): 0.4978617673811346
- Combined Prediction Score: 0.6249602240395019
- Mean Citation Score: 172.705748
- Max Citation Score: 177.74353
- Similarity Product: 114.72463488694012

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test