PATENT CLAIM ANALYSIS

Application Number: 15888455
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["435", "007100"]

Abstract:
The invention provides a method of detecting the presence, absence or severity of a disease in a patient wherein said disease is accompanied by decreased level of S-adenosylmethionine, or increased level of S-adenosylhomocysterine, or reduced methylation index comprising: identifying any individual or a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of SAM in said biological sample using an antibody derived from a hapten analog of SAM, SAH; and correlating the levels of SAM, SAH and MI in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for determining methylation index in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes colloidal gold test strips and homogenous enzyme immunoassays which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

Claim (Index 3):
A method of  claim 1 , for screening and diagnosing whether a subject suffers from liver disease, comprising: identifying, using an anti-SAM antibody, whether said subject has a serum or plasma human SAM concentration at a given threshold value, and thereby diagnosing whether the subject suffers from liver disease.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 88.0
- Lexical Diversity: 2.08861
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14457099', '14218928', '15164856', '12385749', '10579369']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6320692439473297
- 35 USC 102 Novelty (BERT): 0.5589985083509784
- Combined Prediction Score: 0.6247621703876945
- Mean Citation Score: 331.1340380000001
- Max Citation Score: 486.05786
- Similarity Product: 339.6109786958051

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test