PATENT CLAIM ANALYSIS

Application Number: 15874485
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "252040"]

Abstract:
Compounds and compositions are presented that inhibit K-Ras, and especially mutant K-Ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

Claim (Index 2):
A compound having a structure according to Formula I wherein R 9  has the structure according to one of Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, Formula IX, Formula X, Formula XI, Formula XII, Formula XIII and Formula XIV wherein R 1  is selected from the group consisting of H, alkyl, and cycloalkyl; wherein R 2  is selected from the group consisting of H, halo, alkyl, substituted alkyl, fluoroalkyl, cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, aralkyl, polycycloalkyl, hetero-polycycloalkyl, polycycloaryl, hetero-polycycloaryl, acyloxy, alkyloxycarbonyl, amino, amido, sulfonamido, pyrazolyl, and substituted pyrazolyl; wherein R 3  and R 7  are independently H or halo; wherein R 4a  is independently selected from the group consisting of H, alkyl, substituted alkyl, fluoroalkyl, and aryl; wherein R 4b  are independently selected from the group consisting of H, alkyl, substituted alkyl, fluoroalkyl, aryl, and alkyloxy; wherein R 5  is H or alkyl; and wherein R 8  is selected from the group consisting of H, substituted alkyl, aminoalkyl, alkyl amido, cycloalkyl, aralkyl, substituted aralkyl, heteroaralkyl, substituted heteroaralkyl, alkyl cycloalkyl, alkyl heterocycloalkyl, polycycloaryl, alkyloxy, acyloxy, alkyloxycarbonyl, and amino.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 86.0
- Lexical Diversity: 1.36
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15563813', '15093951', '15805716', '15566648', '14511425']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8123175153532205
- 35 USC 102 Novelty (BERT): 0.5296054213015796
- Combined Prediction Score: 0.7840463059480565
- Mean Citation Score: 304.510234
- Max Citation Score: 360.2005
- Similarity Product: 280.55841876542564

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test