PATENT CLAIM ANALYSIS

Application Number: 15864715
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "455000"]

Abstract:
The presently disclosed subject matter provides compositions and methods for the expression of CRISPR guide RNAs using the H1 promoter. In particular, compositions and methods are provided for the use of the H1 promoter to express CRISPR guide RNA (gRNA) with altered specificity of the 5′ nucleotide, as well as use of the H1 promoter sequence as a bidirectional promoter to express Cas9 nuclease and the gRNA simultaneously. Compositions and methods are also provided for the expression and regulation of gRNA expression in vivo through the use of RNA ribozymes and regulatable aptazymes.

Claim (Index 69):
The system of  claim 65 , wherein the cell is a eukaryotic cell optionally selected from the group consisting of (i) a mammalian cell, (ii) a human cell, and/or (iii) a retinal photoreceptor cell.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.85185
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14951240', '15127087', '14971356', '14183486', '14259420']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6440759822163973
- 35 USC 102 Novelty (BERT): 0.5963865034772582
- Combined Prediction Score: 0.6393070343424835
- Mean Citation Score: 408.73407000000014
- Max Citation Score: 603.0151
- Similarity Product: 436.7747796675086

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test