PATENT CLAIM ANALYSIS

Application Number: 15731991
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-03
Patent Classification: ["424", "094200"]

Abstract:
The Cloning and Expression of Comosain's Minigene and the Methods and Compositions for treating and/or preventing various types of cancer which comprise administered an effective amount of Glyco-polypeptides and Bioflavonoids such as Comosain, Ananase, Bromelainases, Trypsin, Pepsin, Quercetin, Rutin, Naringenin, Genistein, Hesperetin, etc and/or a mixture thereof.

Claim (Index 7):
7 ). The method of  claim 3 , where in the antitumor, anti-bacteria, and anti-inflammation effects are through T cells, and mononuclear cells. Massive cascade production of Interleukins IIB, II6, II8, and TNF\u03b1 from TCRS/CD-2, TCRS/CD-3 which induce lyses of surface antigens of CD-44, CD-44s, CD-44v, CD-45, CD-47 in bacteria and tumor cells. And Through the following mechanism and pathways:\n (A) First signal is generated with antigen peptide presented by the Major Histocompatibility Complex (MHC) expressed on Antigen Presenting Cells (APCs). \n (B) The second stimulatory signal is generated by ligation of CD28 receptors on T-cells with B-7 family of ligands on APC. \n (C) A key element in the signaling pathway involved in transducing receptor-initiated signals to the nucleus is the Major Mitogen Activating Protein Kinases, (MMAPK) and through Extracellular Signal-Regulated Protein Kinase of ERK-1 and ERK-2., ERKs are serine/threonine kinase (TPK, Tyrosine phosphorylation kinase) that are activated when phosphorylated on Tyrosine and Threonine residues. There are two other members of MMAPK that is C-JUN (NH) 2, (JNKs) which also require phosphorylation for activation. All the above events of signaling require Tyrosine Phosphorylation as inhibitors of Protein Tyrosine Kinase (PTKS) inhibit many events associated T-Cell receptors (TCRS) activation and Interleukin IIB, II-6, II-8) and TNFs (Tumor Necrotizing Factors) massive production.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 95.0
- Lexical Diversity: 1.37209
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15272826', '14003629', '12861152', '11214831', '10617943']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7145528309958349
- 35 USC 102 Novelty (BERT): 0.5052896519139394
- Combined Prediction Score: 0.6936265130876453
- Mean Citation Score: 172.64342000000005
- Max Citation Score: 186.47795
- Similarity Product: 106.56502436322567

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test