PATENT CLAIM ANALYSIS

Application Number: 16008378
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "277000"]

Abstract:
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

Claim (Index 34):
A compound of Formula IIIA: or a pharmaceutically acceptable salt thereof, wherein: R a  is present 1, 2, 3 or 4 times, and each R a  is independently selected from the group consisting of hydrogen, amino, oxo, halo, alkoxy, alkyl, haloalkyl, \u2014N(alkyl) 2 , \u2014NH(CO)O-alkyl, 1H-pyrazole, 1H-imidazole, and \u2014C(O)NH 2 ; the pyridine to which R a  is attached can comprise a N-oxide formed with its N atom member; and R 1  is \u2014NR 3 R 4 , haloalkyl, cycloalkyl, aryl, heterocycloalkyl, or heteroaryl; R 3  is H, alkyl, or \u2014S(O) 2 alkyl; R 4  is alkyl, hydroxyalkyl, \u2014S(O) 2 alkyl, \u2014(CH 2 ) q cycloalkyl, \u2014(CH 2 ) q heterocycloalkyl, or monocyclic aryl;\n wherein each of said cycloalkyl or heterocycloalkyl of R 4  is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents which can be the same or different and are independently selected from the group consisting of:\n halo, cyano, alkyl, hydroxyl, hydroxyalkyl, hydroxyalkoxy, haloalkyl, alkoxy, alkylalkoxy, haloalkoxy, arylalkenyl-, aryloxy, benzyloxy, oxo, \u2014(CH 2 ) q \u2014NR b R c , \u2014(CH 2 ) q \u2014CONR b R c , \u2014S(O) 2 -alkyl, \u2014S(O) 2 NH-alkyl, \u2014S(O) 2 -heterocycloalkyl, \u2014S(O) 2 \u2014CF 3 , \u2014C(O)alkyl, \u2014C(O)aryl, \u2014C(O)alkylenylaryl, \u2014C(O)O-alkyl, \u2014(CH 2 ) q cycloalkyl, cycloalkylalkoxy-, aryl, arylalkyl-, \u2014(CH 2 ) q heteroaryl, and \u2014(CH 2 ) q heterocycloalkyl; \n \n wherein said monocyclic aryl of R 4  is substituted with 2 substituents,\n wherein said substituents are located on the 2-position and the 5-position of said monocyclic aryl of R 4 , \n wherein said substituents can be the same or different and are independently selected from the group consisting of: methoxy, ethoxy, chloro, fluoro, and methyl, and \n wherein at least of one of said substituents is methoxy or ethoxy; \n \n wherein each of said cycloalkyl, heterocycloalkyl, aryl or heteroaryl of R 1  is unsubstituted or substituted by one or more halo, nitro, haloalkyl, haloalkoxy, oxo, cyano, alkyl, or alkoxy; \n R b  and R c  are independently selected from the group consisting of H, alkyl, hydroxyalkyl, alkoxy, aryl, alkoxyalkyl, \u2014S(O) 2 alkyl and cycloalkyl; or R b  and R c  can form a 5 or 6 membered heterocycloalkyl group together with the nitrogen atom to which they are attached, wherein said heterocycloalkyl group optionally contains one or more additional heteroatoms selected from the group consisting of N, S and O; and q is 0 or 1.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 94.0
- Lexical Diversity: 1.33333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14115623', '13820489', '15352184', '14115849', '12795575']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8493853613274881
- 35 USC 102 Novelty (BERT): 0.5529304256227604
- Combined Prediction Score: 0.8197398677570154
- Mean Citation Score: 398.660056
- Max Citation Score: 433.11774
- Similarity Product: 348.32084777845154

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test