PATENT CLAIM ANALYSIS

Application Number: 15899795
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["530", "300000"]

Abstract:
The invention relates to a composition in the form of an injectable aqueous solution, the pH of which is between 6.6 and 7.8, including at least: a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and b) a hydrophobized anionic polymer. In one embodiment, the compositions according to the invention also include a prandial insulin.

Claim (Index 18):
A composition in the form of an injectable aqueous solution, the pH of which is between 6.6 and 7.8, comprising at least:\n a) a basal insulin, the isoelectric point pH of which is between 5.8 and 8.5; b) a hydrophobized anionic polymer of formula II-XII: in which,\n l=0 or 1, \n m=0, 1 or 2, \n a=0 or 1, \n n being the degree of polymerization, of between 3 and 1000, and \n \u2014R 1  is a hydrogen \u2014H, \n \u2014R 3  is a radical \u2014CH 2 R\u2032, \n \u2014R 5  is either a \u2014COOH group, or a radical \u2014CH 2 R\u2032, or a radical -k-[D], \n in which:\n -[D] is a radical -[Hy] or -[E]-(o-[Hy]) t ; \n -[E]- is an at least divalent radical comprising from 1 to 15 carbon atoms comprising at least one heteroatom chosen from O, N and S, optionally bearing carboxyl or amine functions and/or -k-[E]-(o) t , comprising from 2 to 16 carbon atoms, is derived from an amino acid, from a dialcohol, from a diamine or from an amine alcohol; \n -[Hy] is a C 8  to C 30  linear or cyclic alkyl group or a C 8  to C 30  alkylaryl or arylalkyl, optionally substituted with one or more C 1  to C 3  alkyl groups, which is derived from a hydrophobic compound; \n k resulting from the reaction between a carboxyl, amine or alcohol function of the precursor of -k-[E]-(o) t  and an alcohol, carboxyl or amine function of the polymer and is a function chosen from the group consisting of ester, amide, carbonate and carbamate functions; \n o resulting from the reaction between a carboxyl, amine or alcohol function of the precursor of -k-[E]-(o) t  and an alcohol or acid function of the precursor of -[Hy] is a function chosen from the group consisting of ester, amide, urea (carbamide), carbonate and carbamate functions; \n \n t is a positive integer equal to 1 or 2; \n or\n \u2014R 1  and \u2014R 3  form a six-membered ring \u2014R 1 \u2014R 3 -=\u2014CH(NHCOCH 3 )\u2014, \n and\n \u2014R\u2032 is chosen from the group consisting of the radicals:\n \u2014OH \n \u2014O-Alk, Alk being a C 1  to C 3  alkyl chain, \n -(f-[A]-COOH), in which:\n [A]- is an at least divalent radical comprising from 1 to 15 carbon atoms comprising at least one heteroatom chosen from O, N and S, optionally bearing carboxyl or amine functions and/or -f-[A]-COOH is derived from an amino acid, from a diacid or from an alcohol acid and is bonded to the backbone of the molecule via a function f; \n f resulting from the reaction between a carboxyl or alcohol or amine function of the precursor of -f-[A]-COOH and a hydroxyl function of the backbone is chosen from the group consisting of ether, ester, carbamate or carbonate functions; \n \n -g-[B]-(k-[D]) p , in which:\n -[B]- is an at least divalent radical comprising from 1 to 15 carbon atoms comprising at least one heteroatom chosen from O, N and S, optionally bearing carboxyl or amine functions and/or -g-[B]-(k-) p  is derived from an amino acid, from a diacid, from a dialcohol, from an alcohol acid, from a diamine or from an amine alcohol and is bonded to the backbone of the molecule via a function g and is bonded to at least one radical -[D] via a function k, \n g resulting from the reaction between a carboxyl or alcohol or amine function of the precursor of -g-[B]-(k-) p  and a function of the backbone is chosen from the group consisting of ether, amine, ester, carbamate or carbonate functions, \n k resulting from the reaction between a carboxyl or alcohol or amine function of the precursor of -g-[B]-(k-) p  and an alcohol or acid function of the precursor of -[D] is chosen from the group consisting of ester, amide or carbamate functions;\n p is a positive integer equal to 1 or 2; \n \n \n \n and -[A]-, -[B]- and -[E]- are identical or different, \n and k and o are identical or different; \n and, if -[B]- is a trivalent radical, then -[D] is a radical -[Hy], \n and the degree of substitution with carboxylate charges is the average number of carboxylate charges per monomer divided by (l+m) and is greater than or equal to 0.4, and the degree of substitution with hydrophobic radicals is the average number of hydrophobic radicals per monomer divided by (l+m) and is less than or equal to 0.5, and, if the hydrophobized anionic polymer is a polysaccharide, then the identical or different glycosidic linkages may be of \u03b1 type and/or of \u03b2 type.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 88.0
- Lexical Diversity: 1.47917
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13571026', '15616470', '15616128', '14712696', '15609670']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6780579412905805
- 35 USC 102 Novelty (BERT): 0.5802496708459408
- Combined Prediction Score: 0.6682771142461165
- Mean Citation Score: 366.218702
- Max Citation Score: 525.11975
- Similarity Product: 395.3567151591777

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test