PATENT CLAIM ANALYSIS

Application Number: 15934541
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["435", "007400"]

Abstract:
Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate to severe traumatic brain injury (TBI), using an early biomarker, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1). Also disclosed here are methods that aid in determining whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels and changes in levels of UCH-L1 in one or more samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

Claim (Index 20):
A method of aiding in determining the extent of traumatic brain injury in a human subject who has sustained or may have sustained a head injury, the method comprising:\n e) performing an assay on at least two samples obtained from the subject, the first sample taken from the subject within 24 hours of the suspected head injury and the second sample taken from the subject from about 3 to about 6 hours after the first sample is taken; f) detecting in the at least two samples an early biomarker of traumatic brain injury, said early biomarker consisting of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), wherein the onset of the presence of UCH-L1 appears within about 0 to about 6 hours after the suspected head injury; g) determining the level of UCH-L1 in each of the first sample and second sample and determining if the level of UCH-L1 decreases or increases from the first sample to the second sample; and h) determining the extent of the traumatic brain injury in the subject based on whether the level of UCH-L1 decreases, increases, or remains the same from the first sample to the second sample, wherein determining the extent of the traumatic brain injury comprises determining whether the subject has sustained a mild or a moderate to severe traumatic brain injury.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 90.0
- Lexical Diversity: 1.88158
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12822560', '11107248', '15802489', '12950142', '14449093']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.583279120522052
- 35 USC 102 Novelty (BERT): 0.5286446385065035
- Combined Prediction Score: 0.5778156723204971
- Mean Citation Score: 317.504772
- Max Citation Score: 339.23605
- Similarity Product: 232.2737143734097

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test