PATENT CLAIM ANALYSIS

Application Number: 16083128
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["544", "277000"]

Abstract:
The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′- methylene-carbocyclic adenosine (FMCA) and 2′-fluoro-6′-methylene-carbocyclic guanosine (FMCG) from a readily available starting material in eight steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, (1S,3R,4R)-3-tert-butoxy-4-(tert-butoxymethyl)-2-fluoro-5-methylenecyclopentanol (compound 8 of scheme 1A or a) in only six (6) steps is also provided. Prodrugs of these compounds are also prepared.

Claim (Index 4):
A process for preparing the compound 2\u2032-Fluoro-6\u2032-Methylene-Carbocyclic Adenosine (FMCA) compound 10 from compound 8 Comprising condensing an amine protected 6-amino purine compound according to the chemical structure: where P represents one or two amine protecting groups (preferably two BOC groups) onto compound 8 in the presence of tiphenylphosphine and diisopropylazidocarboxylate (DIAD) in solvent to produce compound 8P where P represents one or two amine protecting groups (preferably, two BOC groups); and subjecting compound 8P to deprotection to produce compound 10 (FMCA) wherein the synthesis may be conducted in a single pot or in steps, with separation and/or purification to produce either of compounds 8P and compound 10.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 97.0
- Lexical Diversity: 1.37705
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14631209', '15287805', '15609080', '14079412', '13107713']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7288850307390102
- 35 USC 102 Novelty (BERT): 0.5244501934700058
- Combined Prediction Score: 0.7084415470121097
- Mean Citation Score: 235.178488
- Max Citation Score: 306.3729600000001
- Similarity Product: 206.33512189395907

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test