PATENT CLAIM ANALYSIS

Application Number: 16091098
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-08
Patent Classification: ["514", "340000"]

Abstract:
The present invention provides benzamidazole compounds and methods of using the compounds as galectin-1 inhibitors.

Claim (Index 1):
A compound having the formula: wherein\n Ar is selected from the group consisting of C 6-12  aryl and C 5-12  heteroaryl, wherein Ar is substituted with 0 to 4 R 5  groups; \n R 1  is selected from the group consisting of C 1-6  alkyl, \u2014NR 1a R 1b , C 3-10  cycloalkyl, C 3-8  heterocycloalkyl, C 6-12  aryl, and C 5-12  heteroaryl, wherein the aryl is optionally substituted with 1-4 R 1c  groups; \n R 1a  and R 1b  are each independently selected from the group consisting of hydrogen and C 1-6  alkyl; \n R 2  is selected from the group consisting of OR 2a , \u2014NR 2a R 2b , C 5-12  heteroaryl and C 1-6  alkyl-C 5-12  heteroaryl, wherein the heteroaryl is optionally substituted with C 1-6  hydroxyalkyl; \n R 2a  and R 2b  are each independently selected from the group consisting of C 1-6  alkyl, C 1-6  hydroxyalkyl, C 1-6  alkyl-OC(O)CH 3 , and C 1-6  alkyl-NR 2d R 2e , or are combined with the nitrogen to which they are attached to form a C 3-8  heterocycloalkyl having 0 to 2 additional heteroatoms selected from the group consisting of N, O, and S, wherein the C 3-8  heterocycloalkyl is optionally substituted with 1 to 4 R 2c  groups; \n each R 1c  and R 2c  is independently selected from the group consisting of C 1-6  alkyl, halogen, C 1-6  haloalkyl, hydroxy, C 1-6  alkoxy, C 1-6  haloalkoxy, and C 6-12  aryl; \n R 2d  and R 2e  are each independently selected from the group consisting of hydrogen and C 1-6  alkyl, or are combined with the nitrogen to which they are attached to form a C 3-8  heterocycloalkyl having 0 to 2 additional heteroatoms selected from the group consisting of N, O, and S; \n R 3  is selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-8  cycloalkyl, C 3-8  heterocycloalkyl, C 6-12  aryl, and C 5-12  heteroaryl, wherein the heterocycloalkyl, aryl, and heteroaryl are optionally substituted with 0 to 4 R 3a  groups \n each R 3a  is independently selected from the group consisting of C 1-6  alkyl, halogen, C 1-6  haloalkyl, hydroxy, C 1-6  alkoxy, C 1-6  haloalkoxy, C 3-8  cycloalkyl, C 3-8  heterocycloalkyl, C 6-12  aryl, C 5-12  heteroaryl, and \u2014SO 2 \u2014C 6-12  aryl; \n R 4  is selected from the group consisting of hydrogen, C 1-6  alkyl, \u2014C(O)R 4a , \u2014C(O)OR 4a  and \u2014C(O)NR 4a R 4b ; \n each R 4a  and R 4b  is independently selected from the group consisting of hydrogen and C 1-6  alkyl; \n each R 5  and R 6  is independently selected from the group consisting of hydrogen and C 1-6  alkyl; \n R 7  is selected from the group consisting of hydrogen and C 1-6  alkyl-C 6-12  aryl, optionally substituted with 1-4 R 7a  groups each independently selected from the group consisting of C 1-6  alkyl, halogen, C 1-6  haloalkyl, C 1-6  alkoxy, and C 1-6  haloalkoxy; \n X 1  is C 1-6  alkylene; \n X 2  is absent or selected from the groups consisting of C 1-6  alkylene, \u2014C(O)NH\u2014, \u2014C(O)CH(NH 2 )CH 2 \u2014 and \u2014C(O)CH(NH 2 )CH(OH)\u2014; and \n the subscripts n and m are each independently integers from 0 to 3; \n or pharmaceutically acceptable salts and isomers thereof.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 97.0
- Lexical Diversity: 1.06667
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12774544', '13048832', '11995928', '14774387', '15634768']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7970521445087875
- 35 USC 102 Novelty (BERT): 0.5228942741620752
- Combined Prediction Score: 0.7696363574741163
- Mean Citation Score: 310.190956
- Max Citation Score: 319.20123
- Similarity Product: 247.0891267546964

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test