PATENT CLAIM ANALYSIS

Application Number: 16011178
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["548", "262200"]

Abstract:
Described herein is the development of an arenophile-mediated, nickel-catalyzed dearomative trans-1,2-carboamination protocol. A range of readily available aromatic compounds was converted to the corresponding dienes using Grignard reagents as nucleophiles. This strategy provided products with exclusive trans-selectivity and high enantioselectivity was observed in case of benzene and naphthalene. The utility of this methodology was showcased by controlled and stereoselective preparation of small, functionalized molecules. A concise synthesis of (+)-pancratistatin and (+)-7-deoxypancratistatin from benzene using an enantioselective, dearomative carboamination strategy has been achieved. This approach, in combination with the judicious choice of subsequent olefin-type difunctionalization reactions, permits rapid and controlled access to a hexasubstituted core. Finally, minimal use of intermediary steps as well as direct, late stage C-7 hydroxylation provides both natural products in six and seven operations.

Claim (Index 10):
The method of  claim 9  wherein the aromatic substrate is an optionally substituted aryl substrate and the transition metal catalyst comprises a chiral ligand.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 94.0
- Lexical Diversity: 1.45545
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14065815', '10586287', '15109396', '15219710', '15375716']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7495455600268092
- 35 USC 102 Novelty (BERT): 0.501758291183763
- Combined Prediction Score: 0.7247668331425046
- Mean Citation Score: 262.02361800000006
- Max Citation Score: 270.36926
- Similarity Product: 209.17257747428417

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test