PATENT CLAIM ANALYSIS

Application Number: 15970635
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "476000"]

Abstract:
Described herein are compounds and compositions for treating glaucoma and/or reducing intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin or a prostaglandin analog. Compounds described herein include those in which an isoquinoline compound is covalently linked to a prostaglandin or a prostaglandin analog, and those in which an isoquinoline compound and a prostaglandin free acid together form a salt.

Claim (Index 1):
A composition comprising:\n a) a dimesylate salt of a compound according to formula (I): wherein:\n R 1  and R 2  are independently selected from the group consisting of hydrogen and C 1 -C 4  alkyl, or R 1  and R 2  are taken together with the nitrogen atom to which they are attached to form a ring of 3, 4, 5, 6, 7 or 8 member atoms; \n A is selected from the group consisting of \u2014CH 2 NH\u2014, \u2014CH(R 10 )\u2014, \u2014C(CH 3 )R 10 )\u2014, \u2014CH 2 CH 2 \u2014, \u2014CH(R 10 )CH 2 \u2014, \u2014CH 2 CH 2 CH(R 10 )\u2014, \u2014CH 2 CH(R 10 )\u2014, and \u2014C(CH 3 )(R 10 )CH 2 \u2014; \n each R 10  is independently selected from the group consisting of alkyl, alkenyl, alkynyl, amino, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, any of which may be optionally substituted; and \n X 1  and X 2  are independently selected from the group consisting of hydrogen, hydroxy, halogen, alkyl, amino, nitro, cyano, carbonylamino, alkoxy, aryloxy, sulfonyl, sulfonamido, thioalkyl, and carboxyl; and \n b) a prostaglandin or a prostaglandin analog.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.65
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15627238', '15901361', '15236625', '15142461', '14213961']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8282514722747415
- 35 USC 102 Novelty (BERT): 0.5876396470531299
- Combined Prediction Score: 0.8041902897525803
- Mean Citation Score: 499.5718920000001
- Max Citation Score: 516.87463
- Similarity Product: 437.2629748911572

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test