PATENT CLAIM ANALYSIS

Application Number: 15975130
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "171000"]

Abstract:
The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Claim (Index 1):
A compound represented by the general formula (I) or a salt, an N-oxide, a solvate, or a prodrug thereof: wherein:\n Cy 1  represents a ring selected from a C3-10 monocyclic or bicyclic carbocycle and a 4- to 10-membered monocyclic or bicyclic heterocycle; \n Cy 2  represents a 4- to 10-membered monocyclic or bicyclic heterocycle excluding a heterocycle 1,3-thiazol-5-yl group; \n R 1  represents:\n (1) a halogen; \n (2) a C1-6 alkyl group, C2-6 alkenyl group or C2-6 alkynyl group optionally substituted with a substituent selected from the group consisting of (i) a halogen and \n \n (ii) a hydroxy group;\n (3) a C5-6 monocyclic carbocycle optionally substituted with one or two R 5  groups; \n (4) a 5- to 6-membered monocyclic heterocycle optionally substituted with one or two R 5  groups; \n (5) \u2014S(O) m1 \u2014R 6 ; \n (6) \u2014SO 2 NR 7 R 8 ; \n (7) \u2014C(O)OR 9 ; \n (8) \u2014NR 10 C(O)R 11 ; \n (9) \u2014C(O)NR 12 R 13 ; \n (10) \u2014OR 14 ; \n (11) \u2014NR 15 R 16 ; \n (12) a cyano group; or \n (13) a nitro group; \n \n R 5  represents:\n (1) a halogen; \n (2) \u2014S(O) m2 \u2014R 17 ; \n (3) \u2014SO 2 NR 18 R 19 ; \n (4) \u2014C(O)OR 20 ; \n (5) \u2014NR 21 C(O)R 22 ; \n (6) \u2014C(O)NR 23 R 24 ; \n (7) \u2014OR 26 ; \n (8) \u2014NR 26 R 27 ; \n (9) a cyano group; \n (10) a nitro group; or \n (11) a C1-3 alkyl group optionally substituted with a substituent selected from the group consisting of (i) a halogen, (ii) a hydroxy group and (iii) an oxo group; \n wherein, if two R 5  groups are present, the R 5  groups may be independently the same or different; and \n wherein, if the two R 5  groups are respectively and independently a C1-3 alkyl group or a hydroxy group, and are attached to carbon atoms adjacent to each other on the C5-6 monocyclic carbocycle or the 5- to 6-membered monocyclic heterocycle, the two R 5  groups may, optionally, form a ring together; \n \n R 6  to R 27  respectively and independently represent (1) a hydrogen atom or (2) a C1-6 alkyl group optionally substituted with (i) a halogen or (ii) a hydroxy group; \n when R 18  and R 19  are respectively and independently a C1-6 alkyl group, R 18  and R 19  groups may together form a ring; \n R 2  represents:\n (1) a halogen; \n (2) a C1-6 alkyl group optionally substituted with (i) a halogen or (ii) a hydroxy group; \n (3) a C3-6 cycloalkyl group optionally substituted with (i) a halogen or (ii) a hydroxy group; \n (4) a C1-6 alkoxy group optionally substituted with a halogen; \n (5) \u2014NR 28 R 29 ; \n (6) a 3- to 7-membered monocyclic heterocycle; or \n (7) \u2014O-(3- to 7-membered monocyclic heterocycle); \n \n R 28  and R 29  respectively and independently represent (1) a hydrogen atom or (2) a C1-6 alkyl group optionally substituted with (i) a halogen or (ii) a hydroxy group; \n A 1  and A 2  respectively and independently represent \u2550CR 3 \u2014 or \u2550N\u2014; \n A 3 , A 4 , A 5  and A 6  respectively and independently represent \u2550CR 4 \u2014 or \u2550N\u2014; \n R 3  and R 4  respectively and independently represent a hydrogen atom or a halogen; \n m1 is an integer from 0 to 2; \n m2 is an integer from 0 to 2; \n p is an integer from 0 to 7; \n q is an integer of 0 from 7; and \n r is an integer of 0 from 2; \n wherein, when p, q and r respectively are 2 or more, R 1 , R 2  and R 3  may be respectively and independently represent the same or different group.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 93.0
- Lexical Diversity: 1.89231
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14768727', '15173161', '15679568', '15291700', '15504514']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.9139031212343486
- 35 USC 102 Novelty (BERT): 0.6009587367949499
- Combined Prediction Score: 0.8826086827904087
- Mean Citation Score: 805.8718299999997
- Max Citation Score: 932.92145
- Similarity Product: 474.8267712542743

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test