PATENT CLAIM ANALYSIS

Application Number: 16109477
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["546", "046000"]

Abstract:
Methods are provided for efficient preparation of hydromorphone or hydrocodone by redox isomerization of morphine or codeine allylic alcohols, respectively, using transition metal aminophosphine catalysts formed in situ.

Claim (Index 43):
A method for preparing a pharmaceutically acceptable salt of hydrocodone or a solvate thereof, or a pharmaceutically acceptable salt of hydromorphone or a solvate thereof, comprising\n catalytically converting codeine into hydrocodone or morphine into hydromorphone comprising exposing the codeine or morphine to at least one transition metal complex catalyst to form a reaction mixture comprising the hydrocodone or hydromorphone; removing the transition metal catalyst or a degradant thereof from the reaction mixture to provide hydrocodone base or hydromorphone base; dissolving or diluting the hydrocodone base or hydromorphone base in a first water miscible solvent and adding a pharmaceutically acceptable acid to form a solution; adding to the solution a first slurry of a pharmaceutically acceptable salt of hydrocodone or a pharmaceutically acceptable salt of hydromorphone, respectively, in a solvent system comprising a second water miscible solvent and water to form a second slurry; and isolating a precipitate of the pharmaceutically acceptable salt of the hydrocodone or solvate thereof, or pharmaceutically acceptable salt of the hydromorphone or a solvate thereof, from the second slurry.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 96.0
- Lexical Diversity: 1.10714
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15644266', '11671962', '10495503', '13093892', '12994923']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7691070278217682
- 35 USC 102 Novelty (BERT): 0.5694849905417493
- Combined Prediction Score: 0.7491448240937664
- Mean Citation Score: 298.219792
- Max Citation Score: 509.0364
- Similarity Product: 364.0295831603766

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test