PATENT CLAIM ANALYSIS

Application Number: 15914782
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "093210"]

Abstract:
Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.

Claim (Index 1):
A method of treating an arrhythmia, comprising\n a) obtaining adult stem cells from a patient with an arrhythmic heart, wherein the adult stem cell is obtained from bone narrow, umbilical cord tissue, umbilical cord blood, placenta, adipose tissue, root of hair, or omental fat containing blood vessels; b) inducing lineage commitment of said adult regenerative cells towards Purkinje and pacemaker cardiomyocyte cells through sequential epigenetic re-programming, and c) introducing said Purkinje cells or said pacemaker cells, or both, into said arrhythmic heart.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 90.0
- Lexical Diversity: 1.29167
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14980274', '14357195', '11022172', '15550572', '10342506']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7412785949831956
- 35 USC 102 Novelty (BERT): 0.6856366873679107
- Combined Prediction Score: 0.7357144042216671
- Mean Citation Score: 432.26163
- Max Citation Score: 845.3718
- Similarity Product: 665.9752995285988

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test