PATENT CLAIM ANALYSIS

Application Number: 16143788
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["514", "210000"]

Abstract:
The present invention relates to novel compounds that inhibit Lp-PLA 2  activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA 2 , for example Alzheimer's disease.

Claim (Index 11):
A compound or a pharmaceutically acceptable salt thereof has the structure of Formula (I-4) wherein\n R 1  is selected from the group consisting of H, C 1-3 alkyl and \u2014C(O)\u2014C 1-3 alkyl; and \n R 2  and R 3  together with the carbon to which they are attached form a 4, 5 or 6 membered saturated ring, which ring\n optionally contains one heteroatom ring member selected from N or O, and \n is optionally substituted with one substituent of -L-K, wherein\n L is selected from the group consisting of C(O), CH 2 , and S(O) 2 , and \n K is selected from the group consisting of C 1-3 alkyl, phenyl, and C 3-6 cycloalkyl; \n \n \n or R 1  and R 2  together with the nitrogen and carbon to which they are attached form a 6-membered saturated ring, which ring\n optionally contains one or two additional heteroatom ring member independently selected from the group consisting of N, O, C(O), S, S(O), and S(O) 2 , and \n is optionally substituted with one or more substituents independently selected from the group consisting of OH, halo, NR 1a R 1b , COOH, and \u2014Y\u2014R c , wherein\n Y is absent or is selected from the group consisting of C(O), S(O) 2 , \u2014C(O)\u2014C(O)\u2014, and CH 2 , and \n R c  is selected from the group consisting of \n \u2003C 1-5 alkyl optionally substituted with one or more substituents independently selected from the group consisting of NR 2a R 2b , C 3-6  cycloalkyl, and \u2014COOH, \n \u2003C 1-3 haloalkyl, \n \u2003C 1-3 alkoxyl, \n \u2003NR 3a R 3b , \n \u2003\u2014(CH 2 ) p \u2014C(O)\u2014O\u2014C 1-3 alkyl, wherein p is 1, 2, or 3 and the \u2014(CH 2 ) p \u2014 is optionally substituted by one or more methyl, \n \u2003\u2014(CH 2 ) q \u2014C 3-6  cycloalkyl, wherein q is 1, 2, or 3, the cycloalkyl is optionally substituted with NR 4a R 4b , and the \u2014(CH 2 ) q \u2014 is optionally substituted by one or more methyl, and \n \u2003heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of halo and NR 5a R 5b , \n \n wherein R 1a , R 1b , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , R 5a , and R 5b  are independently H or C 1-3 alkyl; and \n \n R 3  is H; \n each occurrence of R 4  is independently H or D; \n X is absent or is selected from the group consisting of\n \u2014O\u2014, \n \u2014NH\u2014, and \n \u2014N(C 1-3  alkyl)-, \n \n n is 1 or 2; \n X is \u2014O\u2014CH 2 \u2014 bicyclo[1.1.1]pentanyl-CH 2 \u2014O\u2014 and n is 0; and \n A is unsubstituted thiophenyl, or \n A is \n wherein\n R 5  and R 9  are independently H or halo, \n Z\u2032 is N or CR 6 , \n Z is N or CR 8 ,\n wherein R 6  and R 8  are independently selected from the group consisting of H, CN, halo, C 1-3 alkyl, C 1-3 haloalkyl, \u2014S(O) 2 \u2014C 1-3 alkyl and \u2014S(O)\u2014C 1-3  alkyl, and \n \n V is CR 7 , wherein R 7  is -Q-(CH 2 ) m \u2014W, wherein\n Q is O, N, or CH 2 , \n m is 0 or 1, and \n W is 6 membered heteroaryl wherein said heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of C 1-3 haloalkyl, CN, halo and C 1-5  alkyl.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 97.0
- Lexical Diversity: 1.32353
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15327706', '14761636', '14234680', '14234687', '14569970']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.847197994487579
- 35 USC 102 Novelty (BERT): 0.5713743150858489
- Combined Prediction Score: 0.819615626547406
- Mean Citation Score: 381.661348
- Max Citation Score: 451.69055
- Similarity Product: 443.2430735467374

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test