PATENT CLAIM ANALYSIS

Application Number: 15947192
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["435", "006110"]

Abstract:
The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.

Claim (Index 11):
A method of detecting breast or prostate cancer, or a genetic predisposition to breast or prostate cancer, in a human subject, the cancer being characterized by an elevated amount of mitochondrial DNA (mtDNA) having a deletion in the human mtDNA genome, the deletion having a nucleotide sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2, the method comprising:\n a) contacting mtDNA extracted a biological sample from the subject with at least one binding agent that specifically binds to: i) a sequence of mtDNA having a spliced region after removal of the deletion; or ii) to a sequence of mtDNA comprising the rejoining site of the deletion sequence of SEQ ID NO: 1 or SEQ ID NO: 2 after the deletion sequence has re-circularized; b) quantifying the amount of mtDNA having the deletion by quantifying the amount of mtDNA bound to the at least one binding agent; and, c) detecting said cancer or said predisposition to cancer where the quantified amount of mtDNA having the deletion is elevated in relation to at least one known reference value.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 91.0
- Lexical Diversity: 1.69231
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15470175', '14470627', '11975390', '14627755', '13260497']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6290282827619693
- 35 USC 102 Novelty (BERT): 0.5545975040849891
- Combined Prediction Score: 0.6215852048942714
- Mean Citation Score: 362.00128
- Max Citation Score: 439.74933
- Similarity Product: 364.8862796062911

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test