PATENT CLAIM ANALYSIS

Application Number: 15959318
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "234200"]

Abstract:
The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

Claim (Index 1):
A method for treating a patient suffering from a disease or condition selected from the group consisting of cardiovascular disorders, respiratory disorders, metabolism disorders, skin disorders, bone disorders, neuroinflammatory and/or neurodegenerative disorders, kidney diseases, reproduction disorders, diseases affecting the eye and/or the lens and/or conditions affecting the inner ear, inflammatory disorders, pain, cancers, allergic disorders, traumatisms, septic, hemorrhagic and anaphylactic shock, disorders of the gastrointestinal system, angiogenesis, angiogenesis-dependent conditions, liver disorders and other diseases and disorders associated with Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase), the method comprising administering a pyrazolo pyridine derivative according to Formula (I): wherein G 1  is selected from H; optionally substituted acyl; optionally substituted acyl C 1 -C 6  alkyl; optionally substituted alkyl C 3 -C 8 -cycloalkyl alkyl; optionally substituted heterocycloalkyl alkyl; optionally substituted aryl alkyl; and optionally substituted heteroaryl alkyl; G 2  is selected from H; optionally substituted C 1 -C 6  alkyl; optionally substituted C 2 -C 6  alkenyl; optionally substituted C 2 -C 6  alkynyl; optionally substituted aryl; optionally substituted optionally substituted C 1 -C 6  alkyl aryl; optionally substituted aryl C 1 -C 6  alkyl; optionally substituted heteroaryl; optionally substituted alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 2 -C 6  alkenyl aryl; optionally substituted aryl C 2 -C 6  alkenyl; optionally substituted C 2 -C 6  alkenyl heteroaryl; optionally substituted heteroaryl C 2 -C 6  alkenyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted heterocycloalkyl; optionally substituted alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C 1 -C 6  alkyl; G 3  is selected from H; optionally substituted amino; optionally substituted aminoalkyl; optionally substituted aminocarbonyl; optionally substituted alkoxy; optionally substituted alkoxy C 1 -C 6  alkyl; optionally substituted carbonyl; optionally substituted C 1 -C 6  alkyl; optionally substituted C 2 -C 6  alkenyl; optionally substituted C 2 -C 6  alkynyl; optionally substituted aryl; optionally substituted aryl C 1 -C 6  alkyl; optionally substituted C 1 -C 6  alkyl aryl; optionally substituted heteroaryl; optionally substituted C 1 -C 6  alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 2 -C 6  alkenyl aryl; optionally substituted aryl C 2 -C 6  alkenyl; optionally substituted C 2 -C 6  alkenyl heteroaryl; optionally substituted heteroaryl C 2 -C 6  alkenyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted heterocycloalkyl; optionally substituted C 1 -C 6  alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C 1 -C 6  alkyl; G 4  is selected from \u2014NR 2 \u2014C(O)\u2014R\u2032 and \u2014(CHR 3 ) m \u2014(CH 2 )\u2014 R 4 , wherein R 1  is selected from H; amino; \u2014NR 5 R 6 ; optionally substituted alkoxy; optionally substituted alkoxy C 1 -C 6  alkyl; optionally substituted aryl; optionally substituted C 1 -C 6  alkyl aryl; optionally substituted aryl C 1 -C 6  alkyl; optionally substituted heteroaryl; optionally substituted C 1 -C 6  alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted C 1 -C 6  alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted heterocycloalkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl; and optionally substituted heterocycloalkyl C 1 -C 6  alkyl; R 2  is selected from H; optionally substituted alkoxy C 1 -C 6  alkyl; optionally substituted aryl; optionally substituted C 1 -C 6  alkyl aryl; optionally substituted aryl C 1 -C 6  alkyl; optionally substituted heteroaryl; optionally substituted C 1 -C 6  alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted C 1 -C 6  alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted heterocycloalkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl; optionally substituted heterocycloalkyl C 1 -C 6  alkyl; R 3  is selected from H; halogen; optionally substituted alkoxy; optionally substituted alkoxy C 1 -C 6  alkyl aryl; optionally substituted C 1 -C 6  alkyl aryl; optionally substituted aryl C 1 -C 6  alkyl; substituted heteroaryl; optionally substituted C 1 -C 6  alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted C 1 -C 6  alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted heterocycloalkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl; and optionally substituted heterocycloalkyl C 1 -C 6  alkyl; R 4  is selected from H; C(O)R 7 ; -A-B; CHR 8 R 9  and (CH 2 )q-E; R 5  and R 6  are independently selected from H; optionally substituted alkoxy C 1 -C 6  alkyl; optionally substituted aryl; optionally substituted C 1 -C 6  alkyl aryl; optionally substituted aryl C 1 -C 6  alkyl; optionally substituted heteroaryl; optionally substituted C 1 -C 6  alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted C 1 -C 6  alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted heterocycloalkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl; and optionally substituted heterocycloalkyl C 1 -C 6  alkyl or \u2014NR 5 R 6  form together a ring selected from optionally substituted heteroaryl and optionally substituted heterocycloalkyl; R 7  is selected from optionally substituted amino; optionally substituted alkoxy; optionally substituted aminoalkyl; optionally substituted alkoxy C 1 -C 6  alkyl; optionally substituted C 1 -C 6  alkyl; optionally substituted C 2 -C 6  alkenyl; optionally substituted C 2 -C 6  alkynyl; \u2014NR 5 R 6 ; optionally substituted aryl; optionally substituted C 1 -C 6  alkyl aryl; optionally substituted aryl C 1 -C 6  alkyl; optionally substituted heteroaryl; optionally substituted C 1 -C 6  alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted C 1 -C 6  alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted heterocycloalkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl; and optionally substituted heterocycloalkyl C 1 -C 6  alkyl; R 8  and R 9  are independently selected from optionally substituted aryl; optionally substituted heteroaryl; optionally substituted C 3 -C 8 -cycloalkyl and optionally substituted heterocycloalkyl; R 10  is selected from optionally substituted aryl and optionally substituted heteroaryl; R 11  and R 12  are independently selected from H; optionally substituted acyl; optionally substituted C 1 -C 6  alkyl; optionally substituted C 2 -C 6  alkenyl; optionally substituted C 2 -C 6  alkynyl; optionally substituted aryl; optionally substituted C 1 -C 6  alkyl aryl; optionally substituted aryl C 1 -C 6  alkyl; optionally substituted heteroaryl; optionally substituted C 1 -C 6  alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted C 1 -C 6  alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted heterocycloalkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl; and optionally substituted heterocycloalkyl C 1 -C 6  alkyl or \u2014NR 11 R 12  form together a ring selected from optionally substituted heteroaryl and optionally substituted optionally substituted heterocycloalkyl; R 13  is selected from optionally substituted aryl; optionally substituted heteroaryl; optionally substituted C 3 -C 8 -cycloalkyl and optionally substituted heterocycloalkyl; R 14 , R 15  and R 16  are independently selected from H and optionally substituted C 1 -C 6  alkyl; R 17  is selected from optionally substituted C 1 -C 6  alkyl; optionally substituted C 2 -C 6  alkenyl; optionally substituted C 2 -C 6  alkynyl; optionally substituted aryl; optionally substituted C 1 -C 6  alkyl aryl; optionally substituted aryl C 1 -C 6  alkyl; optionally substituted heteroaryl; optionally substituted C 1 -C 6  alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted C 1 -C 6  alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted heterocycloalkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl; and optionally substituted heterocycloalkyl C 1 -C 6  alkyl; A is selected from optionally substituted aryl, and optionally substituted heteroaryl; B is selected from \u2014OR 10 , and \u2014(CH2)p-R 13 ; E is selected from optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted C 2 -C 6  alkynyl; \u2014NR 14 R 15 ; and \u2014NR 16 C(O)\u2014R 17 ; m, n, p and q are integers selected from 0 to 5; G 5  is selected from H; optionally substituted C 1 -C 6  alkyl; optionally substituted C 2 -C 6  alkenyl; optionally substituted C 2 -C 6  alkynyl; optionally substituted aryl; optionally substituted C 1 -C 6  alkyl aryl; optionally substituted aryl C 1 -C 6  alkyl; optionally substituted heteroaryl; optionally substituted C 1 -C 6  alkyl heteroaryl; optionally substituted heteroaryl C 1 -C 6  alkyl; optionally substituted C 2 -C 6  alkenyl aryl; optionally substituted aryl C 2 -C 6  alkenyl; optionally substituted C 2 -C 6  alkenyl heteroaryl; optionally substituted heteroaryl C 2 -C 6  alkenyl; optionally substituted C 3 -C 8 -cycloalkyl; optionally substituted heterocycloalkyl; optionally substituted C 1 -C 6  alkyl C 3 -C 8 -cycloalkyl; optionally substituted C 3 -C 8 -cycloalkyl C 1 -C 6  alkyl; optionally substituted C 1 -C 6  alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C 1 -C 6  alkyl; or a tautomer, geometrical isomer, enantiomer, diastereomer, racemate or pharmaceutically acceptable salts thereof, to a patient in need of treatment of said disease or condition.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 91.0
- Lexical Diversity: 1.16216
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13755617', '13120438', '14750019', '13120440', '13734205']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8237821286029667
- 35 USC 102 Novelty (BERT): 0.611605812958117
- Combined Prediction Score: 0.8025644970384818
- Mean Citation Score: 637.4256419999998
- Max Citation Score: 646.59875
- Similarity Product: 459.2610350438952

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test