PATENT CLAIM ANALYSIS

Application Number: 15968950
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "006900"]

Abstract:
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position T of GLP-1(7-37), where T is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to GLP-1(7-37); wherein the first K residue is designated K 27 , and the second K residue is designated K T ; which derivative comprises two albumin binding moieties attached to K 27  and K T , respectively, via a linker, wherein the albumin binding moiety comprises a protracting moiety selected from HOOC—(CH 2 ) 2 —CO— and HOOC—C 6 H 4 —O—(CH 2 ) y —CO—; in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; wherein the linker comprises an element of the formula —NH—(CH 2 ) 2 —(O—(CH 2 ) 2 ) k —O—(CH 2 ) n —CO—, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel GLP-1 analogues. The derivatives are suitable for oral administration.

Claim (Index 13):
The derivative of  claim 10 , wherein\n Xaa 7  is selected from the group consisting of L-histidine, imidazopropionyl, \u03b1-hydroxy-histidine, D-histidine, desamino-histidine, 2-amino-histidine, \u03b2-hydroxy-histidine, homohistidine, N \u03b1 -acetyl-histidine, N \u03b1 -formyl-histidine, \u03b1-fluoromethyl-histidine, \u03b1-methyl-histidine, 3-pyridylalanine, 2-pyridylalanine, and 4-pyridylalanine; Xaa 8  is selected from the group consisting of Ala, Gly, Val, Leu, Ile, Thr, Ser, Lys, Aib, (1-aminocyclopropyl) carboxylic acid, (1-aminocyclobutyl) carboxylic acid, (1-aminocyclopentyl) carboxylic acid, (1-aminocyclohexyl) carboxylic acid, (1-aminocycloheptyl) carboxylic acid, and (1-aminocyclooctyl) carboxylic acid; Xaa 12  is Phe; Xaa 16  is Val; Xaa 18  is Ser; Xaa 19  is Tyr; Xaa 20  is Leu; Xaa 22  is selected from the group consisting of Gly, Glu, Lys, and Aib; Xaa 23  is Gln; Xaa 25  is selected from the group consisting of Ala and Val; Xaa 26  is selected from the group consisting of Val, His, and Arg; Xaa 30  is selected from the group consisting of Ala, Glu, and Arg; Xaa 31  is selected from the group consisting of Trp and His; Xaa 34  is selected from the group consisting of Glu, Asn, Gly, Gln, and Arg; Xaa 35  is selected from the group consisting of Gly and absent; Xaa 36  is selected from the group consisting of Arg and absent; Xaa 37  is selected from the group consisting of Gly and absent; Xaa 38  is selected from the group consisting of Ser and absent; and Xaa 39  is selected from the group consisting of Gly and absent.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 93.0
- Lexical Diversity: 2.62162
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15346323', '14009902', '14961064', '13883946', '13882947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8781966375574076
- 35 USC 102 Novelty (BERT): 0.6356765619725544
- Combined Prediction Score: 0.8539446299989223
- Mean Citation Score: 570.27306
- Max Citation Score: 599.13586
- Similarity Product: 582.4002685355425

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test