PATENT CLAIM ANALYSIS

Application Number: 15947098
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "017100"]

Abstract:
A scaffold for promoting cartilage formation is provided that includes a crosslinked electrospun fiber, wherein the crosslinked electrospun fiber consists essentially of crosslinked gelatin. The crosslinked electrospun fiber is generally crosslinked with a crosslinker, and the crosslinker may be diisosorbide bisepoxide. The crosslinked electrospun fiber may be crosslinked by adding a crosslinker to a solution of gelatin at a desired concentration. The electrospun fiber may advantageously remain intact for 18 days or longer upon being immersed in an aqueous solution. A composition for promoting cartilage formation is also provided that includes the disclosed scaffold and a mesenchymal stem cell (MSC). The disclosed scaffold may include a crosslinked electrospun fiber that includes gelatin and sodium cellulose sulfate (NaCS), e.g., in an amount of up to 5% by weight of the amount of gelatin. A method for promoting cartilage formation is also provided that includes administering to a subject in need thereof a disclosed composition for promoting cartilage formation in the subject.

Claim (Index 1):
A mimetic of articular cartilage comprising:\n a fiber reinforced composite hydrogel of\n a crosslinked electrospun fiber comprising gelatin, wherein the fiber is formed into an electrospun mat that defines a volume; and \n a crosslinked hydrogel comprising gelatin and sodium cellulose sulfate (NaCS) in the amount of 5-20% by weight of the amount of gelatin, \n wherein the crosslinked hydrogel has been cast and allowed to gel prior to combination with the electrospun mat; wherein the crosslinked hydrogel has been combined with the crosslinked electrospun fiber so as to occupy the volume of the electrospun mat, and wherein the crosslinked hydrogel and the electrospun mat are not crosslinked together in the fiber reinforced composite hydrogel.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 91.0
- Lexical Diversity: 2.31579
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12661242', '13552550', '13097657', '12420088', '14497274']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7298170855303605
- 35 USC 102 Novelty (BERT): 0.498439842845884
- Combined Prediction Score: 0.7066793612619129
- Mean Citation Score: 201.470142
- Max Citation Score: 241.61855
- Similarity Product: 174.268257108295

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test