PATENT CLAIM ANALYSIS

Application Number: 16026397
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["546", "323000"]

Abstract:
The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from such method of purification.

Claim (Index 2):
The compound of  claim 1 ; wherein PG is utilized for the reversible protection of an amine functional group and wherein PG comprises a moiety of formula (Aa), (Ab), or (Ac): wherein:\n the dashed line marked with the asterisk indicates attachment to T and the unmarked dashed line indicates attachment to the nitrogen of an amine functional group; \n n is 0, 1, 2, 3, or 4; \n \u2014X\u2014 is a chemical bond or a spacer; \n \u2550Y 1  is selected from the group consisting of \u2550O and \u2550S; \n \u2014Y 2 \u2014 is selected from the group consisting of \u2014O\u2014 and \u2014S\u2014; \n \u2014Y 3 \u2014 and \u2014Y 5 \u2014 are independently of each other selected from the group consisting of \u2014O\u2014 and \u2014S\u2014; \n \u2014Y 4 \u2014 is selected from the group consisting of \u2014O\u2014, \u2014NR 5 \u2014, and \u2014C(R 6 R 6a )\u2014; \n \u2014R 2 , \u2014R 3 , \u2014R 4 , \u2014R 5 , \u2014R 6 , and R 6a  are independently of each other selected from the group consisting of \u2014H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, 2-methylbutyl, 2,2-dimethylpropyl, n-hexyl, 2-methylpentyl, 3-methylpentyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, and 3,3-dimethylpropyl; \n \u2014W\u2014 is selected from the group consisting of C 1-20 , alkyl optionally interrupted by one or more groups selected from the group consisting of \u2014O\u2014, \u2014S\u2014 and \u2014N(R 7 )\u2014; \n -Nu is a nucleophile selected from the group consisting of \u2014N(R 7 R 7a ), \u2014N(R 7 OH), \u2014N(R 7 )\u2014N(R 7a R 7b ), \u2014S(R 7 ), \u2014COOH, \n -Nu\u2032 is a nucleophile selected from the group consisting of \u2014N(R 7 )\u2014, \u2014N(OH)\u2014, \u2014N(R 7 )\u2014N(R 7a )\u2014, \u2014S\u2014, \u2014C(O)O\u2014, wherein:\n the unmarked dashed line indicates attachment to the rest of the moiety of formula (Ac); and \n the dashed line marked with the asterisk indicates attachment to T; \n \u2014Ar\u2014 is selected from the group consisting of: wherein:\n dashed lines indicate attachment to the rest of the prodrug, \n \u2014Z 1 \u2014 is selected from the group consisting of \u2014O\u2014, \u2014S\u2014, and \u2014N(R 7 )\u2014; and \n \u2014Z 2 \u2014 is \u2014N(R 7 )\u2014; and \n \u2014R 7 , R 7a , and \u2014R 7b  are independently of each other selected from the group consisting of \u2014H, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl; wherein the moiety of formula (Aa), (Ab), or (Ac) is optionally further substituted.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 95.0
- Lexical Diversity: 1.17391
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15027976', '14435350', '12990101', '14238437', '14650175']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8382204809959328
- 35 USC 102 Novelty (BERT): 0.5687619007433357
- Combined Prediction Score: 0.8112746229706731
- Mean Citation Score: 374.628792
- Max Citation Score: 520.1981
- Similarity Product: 362.7874436082363

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test