PATENT CLAIM ANALYSIS

Application Number: 16069932
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["530", "399000"]

Abstract:
The invention relates to compounds derived from the EGF(A) domain of LDL-R, in particular compounds comprising a peptide analogue of the wild-type EGF(A) (LDL-R(293-332)) sequence and at least one substituent comprising at least one fatty acid group. The invention also relates to a pharmaceutical composition thereof and use a medicament. The novel EGF(A) compounds of the invention are useful as treatment e.g. in the field of cholesterol lowering, dyslipidaemia and cardiovascular disease.

Claim (Index 4):
The EGF(A) derivative according to  claim 1 , wherein the EGF(A) derivative comprises one or two substituent(s) selected from the group consisting of:\n HOOC\u2014(CH 2 ) 18 \u2014CO-gGlu-2\u00d7ADO- HOOC\u2014(CH 2 ) 18 \u2014CO\u2014NH\u2014CH 2 \u2014(C 6 H 10 )\u2014CO-gGlu-2\u00d7ADO- HOOC\u2014(CH 2 ) 16 \u2014CO-gGlu-2\u00d7ADO- HOOC\u2014(CH 2 ) 16 \u2014CO-gGlu-2\u00d7ADO\u2014NH\u2014CH 2 \u2014(C 6 H 4 )\u2014CH 2 - HOOC\u2014(CH 2 ) 16 \u2014CO-gGlu- HOOC\u2014(CH 2 ) 16 \u2014CO\u2014NH\u2014CH 2 \u2014(C 6 H 10 )\u2014CO-gGlu-2\u00d7ADO- HOOC\u2014(CH 2 ) 14 \u2014CO-gGlu-2\u00d7ADO- HOOC\u2014(CH 2 ) 14 \u2014CO-gGlu- HOOC\u2014(CH 2 ) 14 \u2014CO-gGlu-2\u00d7ADO- HOOC\u2014(CH 2 ) 12 \u2014CO-gGlu-2\u00d7ADO- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 10 \u2014CO-gGlu-2\u00d7ADO- 4-HOOC\u2014(C6H4)-O-(CH2)10-CO-gGlu-3\u00d7ADO- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 10 \u2014CO-gGlu- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 10 -CO-2\u00d7gGlu- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 10 \u2014CO-gGlu-3\u00d7Gly- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 10 -CO-2\u00d7gGlu-2\u00d7ADO- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 10 \u2014CO-gGlu-TtdSuc- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 9 -CO- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 10 \u2014CO-gGlu-4\u00d7ADO- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 10 \u2014CO\u2014NH\u2014CH 2 \u2014(C 6 H 10 )-CO-gGlu-2\u00d7ADO- 4-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 9 \u2014CO-gGlu-2\u00d7ADO- 3-HOOC\u2014(C 6 H 4 )\u2014O\u2014(CH 2 ) 9 \u2014CO-gGlu-2\u00d7ADO- 3-HO-Isoxazole-(CH 2 ) 12 \u2014CO-gGlu-2\u00d7ADO- HOS(O)2-(CH2)15-CO-gGlu-2\u00d7ADO\u2014NH\u2014CH 2 \u2014(C 6 H 4 )\u2014CH 2 \u2014 HOS(O) 2 \u2014(CH 2 ) 13 \u2014CO-gGlu-2\u00d7ADO- Tetrazolyl-(CH 2 ) 15 \u2014CO\u2014NH\u2014SO 2 \u2014(CH 2 ) 3 \u2014CO-ADO-ADO\u2014NH\u2014CH 2 \u2014(C 6 H 4 )\u2014CH 2 - Tetrazolyl-(CH 2 ) 12 \u2014CO-gGlu-2\u00d7ADO- Tetrazolyl-(CH 2 ) 15 \u2014CO-gGlu-2\u00d7ADO- and MeS(O) 2 NH(CO)NH\u2014(CH 2 ) 12 \u2014CO-gGlu-2\u00d7ADO-.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 95.0
- Lexical Diversity: 1.76923
- Patent Class: 530.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15301960', '15966642', '15404808', '14399087', '15315985']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7475588915954028
- 35 USC 102 Novelty (BERT): 0.5194290120029901
- Combined Prediction Score: 0.7247459036361615
- Mean Citation Score: 307.498832
- Max Citation Score: 329.66962
- Similarity Product: 228.8673918443799

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test