PATENT CLAIM ANALYSIS

Application Number: 16170208
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["506", "009000"]

Abstract:
A method of using an exchange-induced remnant magnetization (EXIRM) technique for label free detection of short strands of nucleotides and cancer biomarkers, such as DNA and microRNA strands, DNA/RNA-binding biomarkers, and cancer-specific antigens, with high sensitivity, high specificity, and broad dynamic range. The method may provide a label-free approach aimed to facilitate high reliability, and to require a minimum amount of biochemical reagents.

Claim (Index 13):
A method of simultaneously detecting an array of heterologous nucleotide sequences; the method comprising:\n coating a sample well comprising an array of compartments; wherein the surface of said compartments are alternatively:\n a) coated with hybridized nucleotide double strand comprising a strand comprising a magnetic particle; and \n b) uncoated; wherein said uncoated compartment produces no magnetic signal; and \n each said coated compartment comprises a heterologous hybridized double strand sequence; \n c) measuring magnetic signals for each compartment; \n d) incubating said array with a sample comprising free target nucleotide sequences, and forming exchange products; \n e) measuring magnetic signals for each compartment comprising exchange products; \n f) calculating the difference in said signals from step c and e wherein the difference in said signals comprises a decrease in magnetic signals due to the randomization of magnetic dipoles; and \n g) quantifying and identifying said target sequence based on the change in signal calculated in f.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 97.0
- Lexical Diversity: 1.39623
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12835869', '11958180', '15450675', '15209090', '14571142']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6240032154436889
- 35 USC 102 Novelty (BERT): 0.5061695501837539
- Combined Prediction Score: 0.6122198489176953
- Mean Citation Score: 276.811358
- Max Citation Score: 279.44
- Similarity Product: 203.42000714302063

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test