PATENT CLAIM ANALYSIS

Application Number: 15956613
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "183000"]

Abstract:
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Claim (Index 1):
A unit dose of a pharmaceutical composition formulated for treating of an ophthalmic disease or disorder in a subject in need thereof;\n wherein the composition comprises an amount of a small-molecule means for selectively inhibiting Bcl-2 or Bcl-xL, contained in a formulation configured for administration intraocularly or intravitreally; wherein the formulation of the composition and the amount of the means for selectively inhibiting Bcl-2 or Bcl-xL in the unit dose configure the unit dose to be effective in killing senescent cells in the eye that are causing symptoms of the ophthalmic disease or disorder.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 91.0
- Lexical Diversity: 1.58333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15827539', '15955542', '15647688', '15114762', '15467129']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8776099982883537
- 35 USC 102 Novelty (BERT): 0.6540321021592037
- Combined Prediction Score: 0.8552522086754387
- Mean Citation Score: 675.8258
- Max Citation Score: 696.70026
- Similarity Product: 593.0971947438742

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test