PATENT CLAIM ANALYSIS

Application Number: 15896867
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "303000"]

Abstract:
Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Claim (Index 32):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is selected from CN, OR a , SR a , C(O)R b , C(O)NR c R d , C(O)OR a , OC(O)R b , OC(O)NR c R d , NR j R k , NR c C(O)R b , and NR c C(O)OR a ; Cy A  is 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl comprises one or more ring-forming carbon atoms and 1, 2, or 3 ring-forming heteroatoms independently selected from N, O, and S; wherein the N and S are optionally oxidized; wherein a carbon atom of 5-10 membered heteroaryl is optionally substituted by oxo to form a carbonyl group; and wherein the 5-10 membered heteroaryl is optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ; R 2  is selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, halo, CN, OR a7 , SR a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 , NR c7 R d7 , NR c7 C(O)R b7 , and NR c7 C(O)OR a7 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1 or 2; each R 10  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, halo, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , NR c1 R d1 , NR c1 C(O)R b1 , and NR c1 C(O)OR a1 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, and 5-10 membered heteroaryl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 11 ; each R 11  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, halo, CN, OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , NR c3 R d3 , NR c3 C(O)R b3 , and NR c3 C(O)OR a3 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 12 ; each R 12  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, halo, CN, OR a5 , SR a5 , C(O)R b5 , C(O)NR c5 R d5 , C(O)OR a5 , NR c5 R d5 , NR c5 C(O)R b5  and NR c5 C(O)OR a5 ; each R 20  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, halo, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , NR c2 R d2 , NR c2 C(O)R b2 , and NR c2 C(O)OR a2 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 21 ; each R 21  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, halo, CN, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 , NR c4 C(O)R b4 , and NR c4 C(O)OR a4 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 22 ; each R 22  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, halo, CN, OR a6 , SR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , NR c6 R d6 , NR c6 C(O)R b6 , and NR c6 C(O)OR a6 ; each R a , R c  and R d  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 10 ; R b  is selected from C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 10 ; R j  is selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; R k  is selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; each R a1 , R c1  and R d1  is independently selected from H, C 2-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; wherein said C 2-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 11 ; each R b1  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 11 ; each R a2 , R c2  and R d2 , is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; each R b2  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; each R a3 , R c3  and R d3 , is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; each R b3  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; each R a4 , R c4  and R d4 , is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; each R b4  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; each R a5 , R c5  and R d5 , is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl and C 1-6  haloalkyl; each R b5  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl and C 1-6  haloalkyl; each R a6 , R c6  and R d6  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl and C 1-6  haloalkyl; each R b6  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; each R a7 , R c7 , and R d7  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; and each R b7  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl.

Metadata:
- Claim Count in Document: 70.0
- Percentile: 88.0
- Lexical Diversity: 1.31429
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15698768', '15698788', '12704404', '11980314', '13245333']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8162813113998734
- 35 USC 102 Novelty (BERT): 0.5481733961686006
- Combined Prediction Score: 0.7894705198767461
- Mean Citation Score: 363.79944
- Max Citation Score: 405.0963
- Similarity Product: 347.5772775851011

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test