PATENT CLAIM ANALYSIS

Application Number: 15946402
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["424", "085200"]

Abstract:
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

Claim (Index 1):
A polypeptide complex comprising an interleukin polypeptide or portion thereof, and an interleukin receptor polypeptide or portion thereof capable of binding said interleukin polypeptide, and wherein said interleukin polypeptide component and said interleukin receptor polypeptide component are pre-coupled.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 91.0
- Lexical Diversity: 2.21795
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15158210', '11435497', '15156618', '13368605', '14567382']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8354653021494491
- 35 USC 102 Novelty (BERT): 0.5948337913786117
- Combined Prediction Score: 0.8114021510723655
- Mean Citation Score: 632.3829900000002
- Max Citation Score: 638.5672
- Similarity Product: 432.9167631365298

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test