PATENT CLAIM ANALYSIS

Application Number: 15932251
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "136100"]

Abstract:
Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.

Claim (Index 109):
A bispecific binding molecule comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2, wherein the bispecific binding molecule is a bispecific binding protein comprising one or more polypeptide chains, and wherein the bispecific binding molecule comprises two light chains comprising a structure represented by the formula:\n V L1 -L 5 -V L2 -L 6 -C L \u2003\u2003[III] and two heavy chains comprising a structure represented by the formula:\n V H1 -L 7 -V H2 -L 8 -C H1 -hinge-C H2 -C H3 \u2003\u2003[IV] \n wherein: V L1  is a first immunoglobulin light chain variable domain; V L2  is a second immunoglobulin light chain variable domain; V H1  is a first immunoglobulin heavy chain variable domain; V H2  is a second immunoglobulin heavy chain variable domain; C L  is an immunoglobulin light chain constant domain; C H1  is an immunoglobulin C H1  heavy chain constant domain; C H2  is an immunoglobulin C H2  heavy chain constant domain; C H3  is an immunoglobulin C H3  heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1  and C H2  domains; and L 5 , L 6 , L 7 , and L 8  are amino acid linkers; wherein the V H1  and V L1  domains form a V H1 /V L1  binding pair, and wherein the V H2  and V L2  domains form a V H2 /V L2  binding pair.

Metadata:
- Claim Count in Document: 40.0
- Percentile: 88.0
- Lexical Diversity: 1.43243
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14400642', '14075755', '14539845', '14358520', '15315371']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7587346264240553
- 35 USC 102 Novelty (BERT): 0.5579754889392232
- Combined Prediction Score: 0.7386587126755721
- Mean Citation Score: 462.67613
- Max Citation Score: 468.49353
- Similarity Product: 290.6392058278209

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test