PATENT CLAIM ANALYSIS

Application Number: 16049109
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["514", "04400A"]

Abstract:
The present invention encompasses a class of compounds known as splice modulating oligonucleotides (SMOs) that modulate pre-mRNA splicing, thereby affecting expression and functionality of a specific protein in a cell. The present invention further provides compositions and methods for modulating pre-mRNA splicing using a SMO of the invention to abrogate disease-causing mutations in a protein. Accordingly, the present invention provides compositions and methods of treating a subject at risk of, susceptible to, or having a disease, disorder, or condition associated with aberrant or unwanted target pre-mRNA expression or activity.

Claim (Index 2):
A composition comprising: a splice modulating oligonucleotide (SMO) sequence that specifically binds a complementary sequence of a pre-mRNA that undergoes splicing to form a mRNA encoding a glutamate activated \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit (GluR), wherein said SMO decreases expression of the flip isoform of said GluR in a cell, wherein said SMO comprises SEQ ID NO: 143 and is selected from SEQ ID Nos 65, 66, 68, 69, 83, 84, 85, 102, 103, 104 and 122.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 95.0
- Lexical Diversity: 1.66667
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14188168', '13144409', '15833539', '14443360', '15117758']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8089624333463153
- 35 USC 102 Novelty (BERT): 0.6718613260572661
- Combined Prediction Score: 0.7952523226174104
- Mean Citation Score: 555.0947259999998
- Max Citation Score: 750.12787
- Similarity Product: 639.9307339233255

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test