PATENT CLAIM ANALYSIS

Application Number: 15965128
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-01
Patent Classification: ["435", "006000"]

Abstract:
The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.

Claim (Index 168):
The method of  claim 164 , wherein step (c) comprises analyzing a fetal nucleus, fetal nucleic acid, fetal protein, or fetal metabolite by one or more of RNA or DNA Fluorescence In Situ Hybridization (FISH), polymerase chain reaction (PCR), telomere length analysis, affinity-based assay, and DNA or RNA hybridization.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 91.0
- Lexical Diversity: 2.20635
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14930313', '13232781', '13452054', '11449149', '10529453']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7342962083186114
- 35 USC 102 Novelty (BERT): 0.5604088746919943
- Combined Prediction Score: 0.7169074749559498
- Mean Citation Score: 418.205426
- Max Citation Score: 508.741
- Similarity Product: 337.2802666460872

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test