PATENT CLAIM ANALYSIS

Application Number: 16017173
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "186100"]

Abstract:
The present invention relates, in part, to compositions and methods for enhancement of an immune response by partial mTOR inhibition, e.g., with low, immune enhancing, doses of an mTOR inhibitor, such as RAD001.

Claim (Index 23):
A method of evaluating a human subject age 65 or older for treatment with a low, immune enhancing, dose of RAD001 to promote or enhance an immune response to an influenza vaccine or antigen, comprising:\n establishing a reference baseline or pre-immunization level of anti-influenza antibody, measuring a baseline or pre-immunization level of anti-influenza antibody in the human subject age 65 or older, and comparing the baseline or pre-immunization level of anti-influenza antibody in the elderly human subject to the reference value, wherein a baseline or pre-immunization level of anti-influenza antibody in the human subject age 65 or older less than the reference value is predictive of a greater RAD001 associated increase in antibody titer for the influenza antigen, and wherein the human subject age 65 or older, once evaluated, is then treated with a low, immune enhancing dose of RAD001, wherein treatment comprises administering a dose of about 0.1 mg of RAD001, orally and once daily.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 94.0
- Lexical Diversity: 1.32258
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15292088', '15105074', '14680860', '15105082', '15821229']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7423707126937931
- 35 USC 102 Novelty (BERT): 0.627395036772789
- Combined Prediction Score: 0.7308731451016927
- Mean Citation Score: 451.929368
- Max Citation Score: 671.71655
- Similarity Product: 513.16489842543

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test