PATENT CLAIM ANALYSIS

Application Number: 16252475
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-08
Patent Classification: ["514", "210210"]

Abstract:
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Claim (Index 36):
A method of treating a disease or disorder in a subject in need thereof, wherein the disease or disorder is selected from the group consisting of a glycolipid storage disease, a disease associated with glycolipid accumulation, a disease that causes renal hypertrophy or hyperplasia, a disease that causes hyperglycemia or hyperinsulemia, a cancer in which glycolipid synthesis is abnormal, an infectious disease caused by organisms which use cell surface glycolipids as receptors or in which synthesis of glucosylceramide is essential or important, atherosclerosis, polycystic kidney disease, renal hypertrophy, diabetes mellitus, breast cancer, renal adenocarcinoma, brain cancer, neuroblastoma, lung cancer, intestinal cancer, pancreatic cancer, prostate cancer, a neuronal disorder, a neuronal injury, an inflammatory disease or disorder, obesity, and Parkinson's disease; the method comprising administering to the subject an effective amount of a compound of Formula I: wherein R 1  is H; or R 1  and R 2  together form \u2014OCH 2 CH 2 O\u2014; R 2  is C 3-6  cycloalkyloxy or 3-6 membered heterocycloalkyloxy; R 3  is H or halogen; R 4  is H or C 1-4  alkyl; R 5  and R 5A  are each independently H or C 1-4  alkyl; X is N or O, and when X is N, the dashed line is a bond to form a double bond, and when X is O, the dashed line is not a bond to form a single bond; Y is C(R 6 ) 2  or O; with the proviso that X and Y are not both O; R 6  at each occurrence is independently H or C 1-4  alkyl; Ring A is phenylene, naphthylene, or 5-10 membered heteroarylene; R 7  at each occurrence is independently halogen, C 1-6 , alkyl, C 1-6  alkoxy, C 3-6  cycloalkyloxy, (C 3-6  cycloalkyl)C 1-6  alkoxy, phenyl, or 5-6 membered heteroaryl, wherein the phenyl and heteroaryl are each optionally substituted with 1, 2, or 3 R 8 ; p is 0, 1, or 2; R 8  at each occurrence is independently halogen, cyano, amino, C 1-6  alkylamino, C 1-6  dialkylamino, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, aminocarbonyl, C 1-6  alkylaminocarbonyl, or C 1-6  dialkylaminocarbonyl; Ring B is a 4-6 membered heterocycloalkyl ring; R 9  at each occurrence is independently halogen, OR 10 , or N(R 10 ) 2 ; R 10  at each occurrence is independently H or C 1-4  alkyl; q is 0, 1, 2, 3, or 4; and optionally a single stereoisomer or mixture of stereoisomers thereof and additionally optionally a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 99.0
- Lexical Diversity: 1.36364
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15556786', '15023337', '15032613', '15346443', '15003207']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7755689364180157
- 35 USC 102 Novelty (BERT): 0.5438095467292083
- Combined Prediction Score: 0.752392997449135
- Mean Citation Score: 334.088402
- Max Citation Score: 419.61343
- Similarity Product: 259.7698582827246

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test