PATENT CLAIM ANALYSIS

Application Number: 16159545
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["424", "136100"]

Abstract:
Disclosed herein are B cell maturation antigen binding proteins with improved binding affinities and improved ability to mediate killing of cancer cells expressing B cell maturation antigen (BCMA). Pharmaceutical compositions comprising the binding proteins disclosed herein and methods of treatment of a cancer or a metastasis thereof using such formulations are further provided.

Claim (Index 1):
A single domain B cell maturation agent (BCMA) binding protein, comprising complementarity determining regions CDR1, CDR2, and CDR3, wherein\n (a) the amino acid sequence of CDR1 is as set forth in X 1 X 2 X 3 X 4 X 5 X 6 X 7 PX 8 G (SEQ ID NO: 1), wherein X 1  is T or S; X 2  is N, D, or S; X 3  is I, D, Q, H, V, or E; X 4  is F, S, E, A, T, M, V, I, D, Q, P, R, or G; X 5  is S, M, R, or N; X 6  is S I, K, S, T, R, E, D, N, V, H, L, A, Q, or G; X 7  is S, T, Y, R, or N; and X 8  is M, G, or Y; (b) the amino acid sequence of CDR2 is as set forth in AIX 9 GX 10 X 11 TX 12 YADSVK (SEQ ID NO: 2), wherein X 9  is H, N, or S; X 10  is F, G, K, R, P, D, Q, H, E, N, T, S, A, I, L, or V; X 11  is S, Q, E, T, K, or D; and X 12  is L, V, I, F, Y, or W; and (c) the amino acid sequence of CDR3 is as set forth in VPWGX 13 YHPX 14 X 15 VX 16  (SEQ ID NO: 3), wherein X 13  is D, I, T, K, R, A, E, S, or Y; X 14  is R, G, L, K, T, Q, S, or N; X 15  is N, K, E, V, R, M, or D; and X 16  is Y, A, V, K, H, L, M, T, R, Q, C, S, or N; and wherein CDR1 is not SEQ ID NO: 473, wherein CDR2 is not SEQ ID NO: 474, and wherein CDR3 is not SEQ ID NO: 475.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 97.0
- Lexical Diversity: 1.39024
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15977968', '15476309', '14805193', '15501620', '15237889']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7259514658391941
- 35 USC 102 Novelty (BERT): 0.5681371124681793
- Combined Prediction Score: 0.7101700305020926
- Mean Citation Score: 425.49164400000006
- Max Citation Score: 469.59668
- Similarity Product: 349.1562129896927

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test