PATENT CLAIM ANALYSIS

Application Number: 15894408
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "007320"]

Abstract:
Provided herein are genetically modified microbes. In one embodiment, a genetically modified microbe includes an exogenous polynucleotide that includes a pheromone-responsive region. In one embodiment, the pheromone-responsive region is derived from a conjugative plasmid from a member of the genus  Enterococcus  spp. The pheromone-responsive region includes a pheromone-responsive promoter and an operably linked coding region encoding an antimicrobial peptide. In one embodiment, a genetically modified microbe includes an exogenous polynucleotide that includes a promoter and an operably linked coding sequence encoding an antimicrobial peptide, where expression of the coding region is controlled by a modulator polypeptide and is altered by a modulating agent, and where the coding region encodes an antimicrobial peptide. Also provided herein are methods of using the genetically modified microbes, including methods for inhibiting growth of an  Enterococcus  spp., a pathogenic  E. coli,  or a pathogenic  Salmonella  spp., for treating a subject, and for modifying a subject's gastrointestinal microflora.

Claim (Index 56):
The method of  claim 38  wherein the modulator polypeptide encoded by the second coding sequence is a tet-repressor polypeptide, a lac-repressor polypeptide, a xyl-repressor polypeptide, or a NisR polypeptide.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 2.38028
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14431044', '14204802', '14426290', '15410205', '13942189']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.544794741095879
- 35 USC 102 Novelty (BERT): 0.5972232359748426
- Combined Prediction Score: 0.5500375905837754
- Mean Citation Score: 343.111464
- Max Citation Score: 641.9362
- Similarity Product: 400.37298240615127

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test