PATENT CLAIM ANALYSIS

Application Number: 15987277
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "210180"]

Abstract:
Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Claim (Index 1):
A compound of formula (I): wherein:\n A is a group of formula (Ia), (Ib), (Ic), or (Id): \n B is a group of formula (IIa), (IIb), (IIc), (IId), (IIe), (IIf), (IIg), (II h), or (Iii): R 1  is H, \u2014CN, linear or branched (C 1 -C 4 )alkyl-, (R 8 )(R 9 )NC(O)\u2014, R 12 O\u2014(C 1 -C 4 )alkylene-, (R 8 )(R 9 )N\u2014(C 1 -C 4 )alkylene-, (C 1 -C 4 )alkyl-C(O)O\u2014(C 1 -C 4 )alkylene-, (R 8 )C(O)O\u2014; (C 1 -C 4 )alkyl-S(O) 2 NH\u2014, (C 1 -C 4 )alkyl-S\u2014, (R 8 )(R 9 )N\u2014, (R 8 )(R 9 )N\u2014(C 1 -C 4 )alkylene-C(O)NH\u2014(C 1 -C 4 )alkylene-, optionally substituted (C 3 -C 7 )heterocycloalkyl-C(O)NH\u2014(C 1 -C 4 )alkylene-, (C 1 -C 4 )alkyl-OC(O)\u2014, or (R 8 )(R 9 )N\u2014(C 1 -C 4 )alkylene-O\u2014(C 1 -C 4 )alkylene-; R 2  is H, linear or branched (C 1 -C 4 )alkyl-, or (C 1 -C 4 )alkyl-O\u2014; R 3  is H or linear or branched (C 1 -C 4 )alkyl-; R 4  is H or linear or branched (C 1 -C 4 )alkyl-; R 5  is H, linear or branched (C 1 -C 4 )alkyl-, R 12 O\u2014(C 1 -C 4 )alkylene-, or R 12 O\u2014; R 6  is H or linear or branched (C 1 -C 4 )alkyl-; R 7  is H or linear or branched (C 1 -C 4 )alkyl-; or R 6  and R 7  may form, together with the nitrogen atom to which they are attached, an optionally substituted 4-7 membered saturated heterocyclic monocyclic ring system, optionally containing a further oxygen or nitrogen heteroatom; X is \u2014CH 2 \u2014, \u2014(R 3 )N\u2014, or \u2014O\u2014; R 8  is H, linear or branched \u2014(C 1 -C 4 )alkyl-, or R 12 O\u2014(C 1 -C 4 )alkylene-; R 9  is H, linear or branched (C 1 -C 4 )alkyl-, optionally substituted (C 3 -C 7 )heterocycloalkyl-, optionally substituted (C 3 -C 7 )cycloalkyl-, R 12 O\u2014(C 1 -C 4 )alkylene-, (R 10 )(R 11 )N\u2014(C 1 -C 4 )alkylene-, or (R 10 )(R 11 )N\u2014(C 1 -C 4 )alkylene-O\u2014(C 1 -C 4 )alkylene-, wherein said (C 1 -C 4 )alkylene- in (C 3 -C 7 )cycloalkyle-, R 12 O\u2014(C 1 -C 4 )alkylene-, (R 10 )(R 11 )N\u2014(C 1 -C 4 )alkylene-, and (R 10 )(R 11 )N\u2014(C 1 -C 4 )alkylene-O\u2014(C 1 -C 4 )alkylene may be optionally substituted with one or more groups selected from the group consisting of linear or branched (C 1 -C 4 )alkyl-, spiro-(C 1 -C 6 )cycloalkyl, and spiro-(C 1 -C 6 )heterocycloalkyl; or R 8  and R 9  may form, together with the nitrogen atom to which they are attached, an optionally substituted 4-7 membered saturated heterocyclic monocyclic ring system, optionally containing a further oxygen or nitrogen heteroatom; R 10  is H, linear or branched (C 1 -C 4 )alkyl-, R 12 O\u2014(C 1 -C 4 )alkylene-, (C 3 -C 7 )cycloalkyl-, or (C 3 -C 7 )heterocycloalkyl-; R 11  is H, linear or branched (C 1 -C 4 )alkyl-, or R 12 O\u2014(C 1 -C 4 )alkylene-; or R 10  and R 11  may form, together with the nitrogen atom to which they are attached, an optionally substituted 4-7 membered saturated heterocyclic monocyclic ring system, optionally containing a further oxygen or nitrogen heteroatom; n is an integer from 1 to 4; m is an integer from 1 to 2; z is an integer from 1 to 2; wherein \u201coptionally substituted\u201d means substitution by one or more groups selected from the group consisting of linear or branched (C 1 -C 4 )alkyl-, halo, R 12 O\u2014(C 1 -C 4 )alkylene-, R 12 O\u2014, oxo, and (C 1 -C 4 )alkyl(C 1 -C 4 )alkyl)N\u2014; R 12  is H or linear or branched (C 1 -C 4 )alkyl-; and the symbol * indicates the point of attachment to the rest of the molecule; with the proviso that when A is (Ib) then R 1  is not H, CH 3  or CN; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 1.18519
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15388350', '14296730', '14895718', '14868516', '14296794']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8519198807077574
- 35 USC 102 Novelty (BERT): 0.585046940806277
- Combined Prediction Score: 0.8252325867176094
- Mean Citation Score: 514.875808
- Max Citation Score: 525.1804
- Similarity Product: 398.2515943192482

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test