PATENT CLAIM ANALYSIS

Application Number: 16022578
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["544", "131000"]

Abstract:
Provided herein are deuterated compounds and compositions useful in increasing PPARδ activity. The compounds have a formula where L 5  comprises at least one deuterium. Exemplary species include The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

Claim (Index 1):
A method, comprising:\n contacting a PPAR\u03b4 protein with an effective amount of a compound, or a composition comprising the compound, wherein the compound has a formula, wherein:\n ring A is selected from a cycloalkylene, heterocycloalkylene, arylene or heteroarylene; \n ring B is selected from aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkylene, heterocycloalkylene, arylene or heteroarylene; \n each R 2  independently is selected from deuterium, halogen, aryl, heteroaryl, aliphatic, heteroaliphatic, cycloaliphatic, NO 2 , OH, amino, amide, aminosulfonyl, carboxyl, carboxyl ester, alkylsulfonyl, SO 3 H, or acyl; \n each R 22  independently is selected from deuterium, halogen, aryl, heteroaryl, aliphatic, heteroaliphatic, cycloaliphatic, NO 2 , OH, amino, amide, aminosulfonyl, carboxyl, carboxyl ester, alkylsulfonyl, SO 3 H, or acyl; \n n is from 0 to 5; \n m is from 0 to 4; \n X is O, NR 30 , sulfonyl, or S; \n R 30  is selected from H or aliphatic, aryl, or cycloaliphatic; \n each L 2  is selected from a bond, aliphatic, heteroaliphatic, arylene, heteroarylene, cycloalkylene, heterocycloalkylene or \u2014CR 23 R 24 \u2014; \n R 23  and R 24  are each independently selected from H, deuterium, halogen, aliphatic, alkyl, \u2014C(O)OR 25  or \u2014C(O)NR 25 R 26 ; \n R 25  and R 26  are each independently selected from hydrogen or aliphatic, alkyl; \n Z is selected from R 1 L 1 C(O)\u2014 or a carboxyl bioisostere; \n L 1  is a bond or \u2014NR 30 \u2014; \n R 1  is hydrogen, aliphatic, \u2014OR 1A , \u2014NR 1A R 1B , \u2014C(O)R 1A , \u2014S(O) 2 R 1A , \u2014C(O)OR 1A , \u2014S(O) 2 NR 1A R 1B  or \u2014C(O)NR 1A R 1B ; \n R 1A , R 1B  are each independently selected from hydrogen or aliphatic, typically aliphatic, alkyl; L 5  is R c1  and R c2  are each independently H, D or alkyl; R c3  is aliphatic or D; p is 0, 1 or 2; ring C is a 5- or 6-membered heterocyclyl or a 5- or 6-membered heteroaryl; each L 3  independently is selected from a bond, aliphatic, \u2014C(O)\u2014, alkylC(O)\u2014, \u2014C(O)alkyl-, or sulfonyl; L 4  is selected from a bond, aliphatic, heteroaliphatic, arylene, heteroarylene, cycloalkylene, heterocycloalkylene or \u2014CR 23 R 24 \u2014; R 3  is selected from \u2014OH, \u2014OR 3A , \u2014NR 3A R 3B , \u2014C(O)R 3A , \u2014S(O) 2 R 3A , \u2014C(O)OR 3A , \u2014S(O) 2 NR 3A R 3B , \u2014C(O)NR 3A R 3B , aliphatic, heteroaliphatic, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or R 3  can be joined with an atom of ring A or ring B to form a fused ring system or may be joined with an atom of L 3  to form a heterocyclic ring system; and R 3A  and R 3B  are independently selected from hydrogen or aliphatic; with the provisos that\n at least one of L 3 , L 4  or R 3  comprises at least one deuterium and at least one L 3  is or comprises a \u2014C(O)\u2014 adjacent to the nitrogen atom; or \n at least one of R c1  and R c2  is D.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 94.0
- Lexical Diversity: 1.40909
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15482385', '15897796', '14874008', '15517893', '15766455']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.818437111771362
- 35 USC 102 Novelty (BERT): 0.642055318772071
- Combined Prediction Score: 0.800798932471433
- Mean Citation Score: 574.296458
- Max Citation Score: 707.3705
- Similarity Product: 553.7067885781229

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test