PATENT CLAIM ANALYSIS

Application Number: 15917383
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["435", "006110"]

Abstract:
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

Claim (Index 11):
The method of  claim 9 , further comprising determining a bias of the PCR and/or allele-specific amplification or a bias of the microarray analysis, and using the bias to statistically correct the determined quantity of each allele at the plurality of SNP loci on the one or more chromosomes or chromosome segments expected to be disomic before the quantity of each allele is used to estimate the ratio of fetal to maternal DNA.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 90.0
- Lexical Diversity: 2.01316
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13300235', '13791397', '14100928', '14446232', '14080656']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.638665034017657
- 35 USC 102 Novelty (BERT): 0.655760721249395
- Combined Prediction Score: 0.6403746027408308
- Mean Citation Score: 543.830408
- Max Citation Score: 630.0790400000002
- Similarity Product: 504.5122171557618

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test