PATENT CLAIM ANALYSIS

Application Number: 15996166
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "267000"]

Abstract:
The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

Claim (Index 21):
A method for treating cancer in a patient having cancer, comprising administering to the patient a therapeutically effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R a  is selected from the group consisting of C 1-3  aliphatic, C 1-3  fluoroaliphatic, -T-R 1 , \u2014R 2 , and -T-R 2 ; T is a C 1-3  alkylene chain optionally substituted with fluoro; R 1  is an optionally substituted aryl, heteroaryl, or heterocyclyl group; R 2  is selected from the group consisting of halo, \u2014C\u2261C\u2014R 3 , \u2014CH\u2550CH\u2014R 3 , \u2014N(R 4 ) 2 , and \u2014OR 5 ; R 3  is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; each R 4  independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; or two R 4  on the same nitrogen atom, taken together with the nitrogen atom form an optionally substituted 5- to 6-membered heteroaryl or 4- to 8-membered heterocyclyl ring having, in addition to the nitrogen atom, 0-2 ring heteroatoms selected from N, O, and S; R 5  is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; and R b  is selected from the group consisting of fluoro, chloro, \u2014CH 3 , \u2014CF 3 , \u2014OH, \u2014OCH 3 , \u2014OCF 3 , \u2014OCH 2 CH 3 , and \u2014OCH 2 CF 3 .

Metadata:
- Claim Count in Document: 50.0
- Percentile: 94.0
- Lexical Diversity: 1.66667
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12231661', '11242413', '12472583', '14810225', '11127855']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7736564162125779
- 35 USC 102 Novelty (BERT): 0.5068486203673048
- Combined Prediction Score: 0.7469756366280506
- Mean Citation Score: 273.41086
- Max Citation Score: 279.73486
- Similarity Product: 205.4517132560957

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test