PATENT CLAIM ANALYSIS

Application Number: 15948789
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["435", "440000"]

Abstract:
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.

Claim (Index 20):
A composition comprising:\n (i) a library of synthesized editing cassettes, each editing cassette comprising: (a) a region homologous to one of a plurality of target regions of a nucleic acid in a cell, (b) a mutation of at least one nucleotide relative to said target region, and (c) a first protospacer adjacent motif (PAM) mutation; and (ii) a plurality of nucleic acids, each encoding a guide RNA (gRNA), wherein each guide RNA comprises a region complementary to a portion of at least one of the plurality of target regions, and wherein there is at least one gRNA comprising complementarity to each of the plurality of target regions of the nucleic acid; wherein the library of synthetic editing cassettes comprises at least two of said editing cassettes with different mutations relative to said target region of each gRNA of the plurality of nucleic acids.

Metadata:
- Claim Count in Document: 95.0
- Percentile: 91.0
- Lexical Diversity: 1.24324
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15116616', '15948785', '15630909', '15948793', '15948798']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7437308581895993
- 35 USC 102 Novelty (BERT): 0.685238654921796
- Combined Prediction Score: 0.7378816378628189
- Mean Citation Score: 619.00742
- Max Citation Score: 749.3602
- Similarity Product: 678.5486944131493

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test