PATENT CLAIM ANALYSIS

Application Number: 15977258
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["506", "002000"]

Abstract:
Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject. TCR and/or IG sequence diversity and sequence distribution permit immunocompetence and immune repertoire assessment and reflect the degree of T cell or B cell clonality and clonal expansion in the sample. Methods for stratifying patient populations on the basis of immunocompetence including likelihood of responding to immunotherapy are also described.

Claim (Index 27):
The method of  claim 17 , wherein the cancer is prostate cancer, melanoma, small cell lung cancer, non-small cell lung cancer, renal cell carcinoma, pancreatic cancer, breast cancer, ovarian cancer, a hematologic malignancy, sarcoma or carcinoma.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 93.0
- Lexical Diversity: 1.50725
- Patent Class: 506.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15637871', '13708847', '14199167', '13656265', '14471821']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5061037535679037
- 35 USC 102 Novelty (BERT): 0.6023672125837491
- Combined Prediction Score: 0.5157300994694882
- Mean Citation Score: 395.108366
- Max Citation Score: 693.2953
- Similarity Product: 427.2526768574954

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test