PATENT CLAIM ANALYSIS

Application Number: 15918757
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "190000"]

Abstract:
The invention relates to novel 7ß-hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus  Collinsella , especially of the strain  Collinsella aerofaciens , to the sequences encoding said enzymes, to methods for producing said enzymes and to their use in the enzymatic conversion of cholic acid compounds, and especially in the production of ursodeoxycholic acid (UDCS). The invention also relates to novel methods for the synthesis UDCS.

Claim (Index 12):
A method for the production of ursodesoxycholic acid (UDCA) of the formula (1) wherein R stands for alkyl, NR 1 R 2 , H, an alkali metal ion or N(R3)4+, wherein the residues R 3  are the same or different and stand for H or alkyl, wherein a) a cholic acid (CA) of the formula (2) wherein R has the aforesaid meanings, is optionally chemically oxidized to the dehydrocholic acid (DHCA) of the formula (3) wherein R has the aforesaid meanings; b) DHCA is reduced in the presence of a recombinant 7\u00df-HSDH as claimed  claim 1  to the 3,12-diketo-7\u00df-cholanic acid (3,12-Diketo-7\u00df-CA) of the formula (4) c) 3,12-diketo-7\u00df-CS is reduced in the presence of at least one 3\u03b1-hydroxysteroid dehydrogenase (3\u03b1-HSDH) to the corresponding 12-keto-ursodesoxycholic acid (12-keto UDCA) of the formula (5) wherein R has the aforesaid meanings, and then d) 12-keto-UDCA of the formula (5) is chemically reduced to UDCA; and e) the reaction product is optionally further purified.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 90.0
- Lexical Diversity: 1.68182
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15314155', '15327887', '15320213', '13699239', '15490416']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7176465658329577
- 35 USC 102 Novelty (BERT): 0.6274682991445755
- Combined Prediction Score: 0.7086287391641195
- Mean Citation Score: 503.390542
- Max Citation Score: 588.01636
- Similarity Product: 557.9999780748557

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test