PATENT CLAIM ANALYSIS

Application Number: 16169900
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-12
Patent Classification: ["250", "282000"]

Abstract:
A method of operating a quadrupole mass filter is disclosed. A first set of RF and resolving DC voltages are applied to electrodes of a quadrupole mass filter to selectively transmit first ions having a first mass-to-charge ratio (m/z). A second set of RF and resolving DC voltages are applied to electrodes of the quadrupole mass filter to selectively transmit second ions having a second m/z. Detection of the second ions is initiated after completion of a settling time. The settling time is determined in accordance with the relationship: Eq. 1, where t s  is the settling time, (m/z) 1  is the first mass-to-charge ratio, (m/z) 2  is the second mass-to-charge ratio and A, B and C are empirically derived coefficients.

Claim (Index 9):
A method of operating a tandem mass spectrometer having a first quadrupole mass filter (Q1), and a second quadrupole mass filter (Q3), and a quadrupole collision cell (Q2) disposed between the first (Q1) and second (Q3) quadrupole mass filters, comprising:\n applying a first set of RF and resolving DC voltages to electrodes of the first (Q1) and second (Q3) quadrupole mass filters to cause the first quadrupole mass filter (Q1) to selectively transmit first precursor ions and the second quadrupole mass filter (Q3) to selectively transmit first product ions; applying a second set of RF and resolving DC voltages to electrodes of the first (Q1) and second (Q3) quadrupole mass filters to cause the first quadrupole mass filter (Q1) to selectively transmit second precursor ions and the third quadrupole mass filter (Q3) to selectively transmit second product ions, wherein at least one of: (i) the first and second precursor ions and (ii) the first and second product ions have mass-to-charge ratios that differ from one another; and initiating detection of the second ions after completion of a settling time, wherein the settling time for each quadrupole Q1, Q2, and Q3 is determined in accordance with the relationships:\n t Q1s =A [( m/z ) 2 \u2212( m/z ) 1 ] B +C \u221a{square root over (( m/z ) 2 )}, \n t Q2s =C *\u221a{square root over (( m/z ) p2 )}, \n t Q3s =A [( m/z ) p2 \u2212( m/z ) p1 ] B +C ( m/z ) p2 , \n in which t Q1s  is the settling time for Q1, t Q2s  is the settling time for Q2, t Q3s  is the settling time for Q3, (m/z) 1  is the first mass-to-charge ratio, (m/z) 2  is the second mass-to-charge ratio, (m/z) p1  is the first product mass-to-charge ratio, (m/z) p2  is the second product mass-to-charge ratio, and A, B, C and C* are empirically derived coefficients, wherein the total settling time is determined in accordance with the relationship:\n t s-tot =MAX{( t Q1s +t Q2s ), t Q3s }.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 2.37931
- Patent Class: 250.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12716138', '15105092', '15524354', '13813894', '11719665']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7355193009693073
- 35 USC 102 Novelty (BERT): 0.5030874463667332
- Combined Prediction Score: 0.7122761155090499
- Mean Citation Score: 290.33192
- Max Citation Score: 301.48096
- Similarity Product: 253.6811285769653

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test