PATENT CLAIM ANALYSIS

Application Number: 15948789
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["435", "440000"]

Abstract:
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.

Claim (Index 1):
A composition comprising:\n (i) a nucleic acid encoding at least a portion of a guide RNA (gRNA) comprising a region complementary to a portion of a target region of a nucleic acid in a cell; and (ii) a library of synthesized editing cassettes, each editing cassette comprising (a) a region homologous to the target region of a nucleic acid in said cell, (b) a mutation of at least one nucleotide relative to said target region, and (c) a first protospacer adjacent motif (PAM) mutation; wherein the library of synthetic editing cassettes comprises at least two of said editing cassettes with different mutations relative to said target region of the nucleic acid.

Metadata:
- Claim Count in Document: 95.0
- Percentile: 91.0
- Lexical Diversity: 1.24324
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15116616', '15948785', '15630909', '15948793', '15948798']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.74229044981388
- 35 USC 102 Novelty (BERT): 0.6897650404991813
- Combined Prediction Score: 0.7370379088824103
- Mean Citation Score: 619.00742
- Max Citation Score: 749.3602
- Similarity Product: 692.0085525272607

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test