PATENT CLAIM ANALYSIS

Application Number: 16193814
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "211000"]

Abstract:
The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof.

Claim (Index 1):
A compound having the structure: wherein A is an aryl or heteroaryl, with or without substitution; R 1  is \u2014H or -(alkyl); R 2  is -(alkyl), -(alkenyl), -(alkynyl), -(alkyl)-OH, -(alkyl)-CO 2 H, -(alkyl)-CO 2 -(alkyl), -(alkyl)-C(O)\u2014NH 2 , -(alkyl)-C(O)\u2014NH(alkyl), -(alkyl)-C(O)\u2014NH-(hydroxyalkyl), -(alkyl)-C(O)\u2014N(alkyl) 2 , -(alkyl)-C(O)\u2014N(hydroxyalkyl) 2 , -(alkyl)-O-(alkyl), -(alkyl)-S-(alkyl), -(alkyl)-CF 3 , -(alkyl)-O-(hydroxyalkyl), -(alkyl)-O-(alkyl)-O-(alkyl), -(alkyl)-(CH)\u2014(O-(alkyl)) 2 , -(alkyl)-(heterocyclyl), -(alkyl)-OAc, -(alkyl)-tetrahydrofuran, -(alkyl)-pyrrolidine, -(alkyl)-N-methylpyrrolidine, -(alkyl)-(1,3-dioxane) or -(alkyl)-(4,5-dihydrooxazole); R 3  is \u2014H or -(alkyl); R 4 , R 5 , R 6  and R 7  are each absent or present, and when present, are each independently \u2014H, \u2014Cl, \u2014Br, \u2014F, \u2014I, \u2014CN, \u2014CF 3 , \u2014OCF 3 , -(alkyl), -(alkenyl), -(alkynyl), -(aryl), \u2014NH 2 , \u2014NH-(alkyl), \u2014NH-(alkenyl), \u2014NH-(alkynyl)-NH-(aryl), \u2014NH-(heteroaryl), \u2014OH, \u2014OAc, \u2014O\u2014C(O) (alkyl), \u2014O-(alkyl), \u2014O-(alkylaryl), \u2014O-(alkenyl), \u2014O-(alkynyl), \u2014O-(aryl), \u2014O-(heteroaryl), \u2014S-(alkyl), \u2014S-(alkenyl), \u2014S-(alkynyl), \u2014S-(aryl), \u2014S-(heteroaryl), \u2014S(O)-(alkyl), \u2014S(O)-(aryl), \u2014S(O)-(heteroaryl), \u2014SO 2 -(alkyl), \u2014SO 2 -(aryl), or \u2014SO 2 -(heteroaryl); and Y 1 , Y 2 , Y 3  and Y 4  are each independently N or C,\n wherein when Y 1  is N, then R 4  is absent, and when Y 1  is C, then R 4  is present; when Y 2  is N, then R 5  is absent, and when Y 2  is C, then R 5  is present; when Y 3  is N, then R 6  is absent, and when Y 3  is C, then R 6  is present; when Y 4  is N, then R, is absent, and when Y 4  is C, then R 7  is present, \n wherein when A is phenyl, R 1  is \u2014CH 3 , R 3 , R 4 , R 6 , and R 7  are each \u2014H, and R 5  is Cl, then R 2  is other than \u2014(CH 2 ) 4 C(O)NH 2 , \u2014(CH 2 ) 4 CO 2 H, \u2014(CH 2 ) 5 CO 2 H, \u2014(CH 2 ) 6 CO 2 H, \u2014(CH 2 ) 7 CO 2 H, \u2014(CH 2 ) 10 CO 2 H, \u2014(CH 2 ) 6 CO 2 CH 2 CH 3 , \u2014(CH 2 ) 6 CH 3 , \u2014(CH 2 ) 20 H, \u2014(CH 2 ) 40 H, \u2014(CH 2 ) 7 OH, wherein when A is phenyl, R 1  is \u2014CH 3 , R 3 , R 4 , R 5 , R 6 , and R 7  are each \u2014H, then R 2  is other than \u2014(CH 2 ) CO 2 CH 2 CH 3 , \u2014(CH 2 ) CO 2 CH 2 CH 3 , (CH 2 )CO 2 H, \u2014(CH 2 ) 3 CO 2 H, \u2014(CH 2 ) 4 CO 2 H or \u2014(CH 2 ) 6 CO 2 H, wherein when R 1  is \u2014CH 3 , R 2  is \u2014(CH 2 ) 5 CO 2 H, R 3  is \u2014H, R 4  and R 7  are each H, R 5  is \u2014Cl and R 6  is \u2014H or R 5  and R 6  are each \u2014H, then A is other than 2-chlorophenyl or 3-chlorophenyl, wherein when R 1  is \u2014CH 3 , R 2  is \u2014(CH 2 ) 5 CO 2 H, R 3  is \u2014H or \u2014CH 3 , R 4  and R, are each \u2014H, R 5  is Cl and R F  is \u2014H or R 6  is \u2014Cl and R 5  is \u2014H, then A is other than phenyl, wherein when R 1  is \u2014CH 3 , R 2  is \u2014(CH 2 ) 3 CO 2 H, R 3  is \u2014CH 3 , and R 4 , R 5 , R 6  and R 7  are each \u2014H, then A is other than phenyl, wherein when A is phenyl, R 1  is \u2014CH 3 , R 3 , R 4 , R 6 , and R 7  are each \u2014H, and R 5  is \u2014SO 2 CH 3 , then R 2  is other than \u2014(CH 2 ) 3 OCH 3 , wherein when A is phenyl, R 1  is \u2014CH 3 , R 3 , R 4 , R 5 , and R 7  are each \u2014H, and R 5  is \u2014F, then R 2  is other than \u2014(CH 2 ) 6 CO 2 H, or a pharmaceutically acceptable salt or ester thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 98.0
- Lexical Diversity: 1.11765
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15125557', '15850123', '15401791', '12218754', '15541018']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8154919754904767
- 35 USC 102 Novelty (BERT): 0.6017046837953232
- Combined Prediction Score: 0.7941132463209614
- Mean Citation Score: 388.969614
- Max Citation Score: 556.03394
- Similarity Product: 454.82844883295775

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test