PATENT CLAIM ANALYSIS

Application Number: 15771043
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-02
Patent Classification: ["514", "021300"]

Abstract:
The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

Claim (Index 25):
A chemically modified polypeptide selected from the group consisting parathyroid hormone (PTH), PYY3-36, cholecystokinin, PYY1-36, corticotropin releasing hormone receptor 1 or 2, growth hormone releasing factor, glucagon, Exendin, GLP-1, gastric inhibitory peptide, Liraglutide, prealbumin, peptide HI-27, PACAP, secretin, and vasoactive intestinal peptide (VIP),\n wherein the N-terminus amino group is derivatized with (i) one selected from the group consisting of optionally substituted C 1 -C 16  alkyl, optionally substituted C 3 -C 16  cycloalkyl, optionally substituted C 2 -C 16  alkenyl and optionally substituted C 2 -C 16  alkynyl, or (ii) one selected from the group consisting of optionally substituted phenyl, optionally substituted benzyl, \u2192O, \u2014OH, alkoxy, NH 2 , NH(C 1 -C 16  alkyl) and N(C 1 -C 16  alkyl)(C 1 -C 16  alkyl), wherein the derivatization stabilizes the polypeptide against degradation by at least one selected from the group consisting of Acylamino-acid-releasing enzyme, DPP4, DPP2, DPP8, DPP9, all S9B family Oligopropyl peptidases and a protease with \u226550% homology to DPP4 and/or DPP2, without reducing the polypeptide's biological activity relative to the corresponding non-chemically modified protein.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 91.0
- Lexical Diversity: 1.59524
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12845455', '13130962', '14182706', '13697021', '12066324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7942408274506368
- 35 USC 102 Novelty (BERT): 0.5036485337251588
- Combined Prediction Score: 0.765181598078089
- Mean Citation Score: 258.376928
- Max Citation Score: 264.86304
- Similarity Product: 190.646189003048

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test