PATENT CLAIM ANALYSIS

Application Number: 16177165
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["424", "188100"]

Abstract:
The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.

Claim (Index 12):
A HIV-1 vaccine immunogen, comprising an HIV-1 Env-derived trimer protein presented on a self-assembling nanoparticle, wherein subunit of the self-assembling nanoparticle comprises the polypeptide as shown in any one of SEQ ID NOs:18 and 5-17, a conservatively modified variant or a substantially identical sequence thereof; and wherein a linker sequence (a) is fused to the C-terminus of the nanoparticle subunit while the HIV-1 trimer protein subunit is fused to the N-terminus of the nanoparticle subunit or (b) links the HIV-1 trimer protein to the N-terminus of the nanoparticle subunit.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 97.0
- Lexical Diversity: 2.125
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16176200', '15508885', '14806742', '14072209', '15075329']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7663788258651163
- 35 USC 102 Novelty (BERT): 0.5655225775765826
- Combined Prediction Score: 0.746293201036263
- Mean Citation Score: 385.3784480000001
- Max Citation Score: 485.73978
- Similarity Product: 351.29292643146874

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test