PATENT CLAIM ANALYSIS

Application Number: 15994074
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "186100"]

Abstract:
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

Claim (Index 18):
The modified virus of  claim 17 , wherein the retrovirus virus is a human immunodeficiency virus (HIV) and wherein the deoptimized viral nucleic acid comprises replacement of at least 20 codons in an env coding sequence with synonymous codons less frequently used in the virus.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 93.0
- Lexical Diversity: 1.57895
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11576941', '12594173', '14766620', '15315687', '15508695']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6946043928681039
- 35 USC 102 Novelty (BERT): 0.7536827341450006
- Combined Prediction Score: 0.7005122269957936
- Mean Citation Score: 435.261758
- Max Citation Score: 906.7351
- Similarity Product: 834.7921601323128

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test