PATENT CLAIM ANALYSIS

Application Number: 15756908
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "006100"]

Abstract:
The invention relates to the use of certain micro-RNAs circulating in the blood serum or blood plasma in the form of diagnostic profiles as a marker in an in vitro method for distinguishing between patients for which a myocardial biopsy is necessary for the diagnostic identification of a heart muscle disease and patients for which myocardial biopsy is not necessary, and for the optional differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases affecting the heart.

Claim (Index 14):
The diagnostic system as claimed in claim  0 , further comprising:\n at least three probes each comprising a sequence corresponding to a sequence of a microRNA from the group consisting of the following microRNAs or complementary to this:\n hsa-miR-1274B (SEQ ID NO: 31), hsa-miR-4449 (SEQ ID NO: 37), hsa-miR-4674 (SEQ ID NO: 38), hsa-miR-5096 (SEQ ID NO: 39), hsa-miR-548c-5p (SEQ ID NO: 41), hsa-miR-1180-3p (SEQ ID NO: 43), hsa-miR-1-3p (SEQ ID NO: 44), hsa-miR-16-5p (SEQ ID NO: 47), hsa-miR-3138 (SEQ ID NO: 52), hsa-miR-3622b-5p (SEQ ID NO: 53), hsa-miR-3922-5p (SEQ ID NO: 54), hsa-miR-4274 (SEQ ID NO: 56), hsa-miR-4303 (SEQ ID NO: 57), hsa-miR-4419b (SEQ ID NO: 58), hsa-miR-4429 (SEQ ID NO: 59), hsa-miR-4467 (SEQ ID NO: 60), hsa-miR-4651 (SEQ ID NO: 61), hsa-miR-4716-5p (SEQ ID NO: 62), hsa-miR-548b-5p (SEQ ID NO: 63), hsa-miR-597-5p (SEQ ID NO: 65), hsa-miR-923 (SEQ ID NO: 70), mmu-miR-374-5p (SEQ ID NO: 71), miR-1274A (SEQ ID NO: 76), hsa-miR-1274B (SEQ ID NO: 77), hsa-miR-223-5p (SEQ ID NO: 88), hsa-miR-328-3p (SEQ ID NO: 95), hsa-miR-378-5p (SEQ ID NO: 97), hsa-miR-423 (SEQ ID NO: 98), hsa-miR-4286 (SEQ ID NO: 99), hsa-miR-4535 (SEQ ID NO: 101), hsa-miR-210-3p (SEQ ID NO: 112), hsa-miR-103b (SEQ ID NO: 117), hsa-miR-1274B (SEQ ID NO: 120), hsa-miR-138-1-3p (SEQ ID NO: 121), hsa-miR-146b-3p (SEQ ID NO: 122), hsa-miR-190a-5p (SEQ ID NO: 123), hsa-miR-26b-3p (SEQ ID NO: 125), hsa-miR-3617-5p (SEQ ID NO: 127), hsa-miR-3663-3p (SEQ ID NO: 129), hsa-miR-3922-5p (SEQ ID NO: 131), hsa-miR-424-5p (SEQ ID NO: 132), hsa-miR-4429 (SEQ ID NO: 134), hsa-miR-4698 (SEQ ID NO: 135), hsa-miR-4726-3p (SEQ ID NO: 136), hsa-miR-4743-5p (SEQ ID NO: 137), hsa-miR-59\u20327-5p (SEQ ID NO: 142), hsa-miR-629-5p (SEQ ID NO: 145), hsa-miR-758-3p (SEQ ID NO: 146), mmu-miR-374-5p (SEQ ID NO: 147), hsa-miR-146b-3p (SEQ ID NO: 151), hsa-miR-3156-5p (SEQ ID NO: 153), hsa-miR-4535 (SEQ ID NO: 157), hsa-miR-487b-3p (SEQ ID NO: 160), hsa-miR-494-3p (SEQ ID NO: 161), hsa-miR-511-5p (SEQ ID NO: 162), hsa-miR-548c-5p (SEQ ID NO: 165), hsa-miR-889-3p (SEQ ID NO: 169), mmu-miR-374-5p (SEQ ID NO: 175).

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.56
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13899555', '14788843', '15320208', '13642321', '15237364']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6392959891048813
- 35 USC 102 Novelty (BERT): 0.5234598231799064
- Combined Prediction Score: 0.6277123725123838
- Mean Citation Score: 338.831186
- Max Citation Score: 342.94568
- Similarity Product: 218.2926115215016

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test