PATENT CLAIM ANALYSIS

Application Number: 16403969
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-09
Patent Classification: ["424", "489000"]

Abstract:
The present invention relates to the field of methods for providing pharmaceutical compositions comprising poorly water-soluble drugs. In particular the present invention relates to compositions comprising stable, amorphous hybrid nanoparticles, comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component, useful in pharmaceutical compositions and in therapy.

Claim (Index 58):
A pharmaceutical composition, comprising:\n (a) amorphous solid dispersion particles having a degree of amorphicity of 100% wherein the particles comprise\n (i) a protein kinase inhibitor in an amount of from about 10% by weight to about 70% by weight of the particles; and \n (ii) at least one polymeric stabilizing and matrix-forming component; \n and (b) optionally at least one pharmaceutically acceptable solubilizer selected from the group consisting of a d-\u03b1-tocopherol acid polyethylene glycol 1000 succinate, a PEG-40 hydrogenated castor oil, a PEG-35 castor oil, a PEG-40 stearate, a hard fat, a polyoxylglyceride, a PEG-8 caprylic/capric glyceride, and a poloxamer; wherein the protein kinase inhibitor is dasatinib, dasatinib hydrate, dasatinib solvate, dasatinib salt, or combinations thereof; and wherein the at least one pharmaceutically acceptable solubilizer, when present, is a physical mixture with the amorphous solid dispersion particles.

Metadata:
- Claim Count in Document: 161.0
- Percentile: 100.0
- Lexical Diversity: 1.48718
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16404004', '15248107', '15791093', '16404059', '16404027']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8628731801852603
- 35 USC 102 Novelty (BERT): 0.7345146842299499
- Combined Prediction Score: 0.8500373305897293
- Mean Citation Score: 847.3071960000003
- Max Citation Score: 852.36774
- Similarity Product: 822.0821227103163

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test