PATENT CLAIM ANALYSIS

Application Number: 16027206
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["424", "215100"]

Abstract:
The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

Claim (Index 41):
The method of claim  1 , wherein the reovirus further comprises one or more polypeptides selected from the group consisting of a mu-1 polypeptide having at least one amino acid modification, wherein the at least one amino acid modification comprises an Asp at residue 73 numbered relative to SEQ ID NO:27 (GenBank Accession No. M20161.1), a mu-2 polypeptide having at least one amino acid modification, wherein the at least one amino acid modification comprises a Ser at residue 528 numbered relative to SEQ ID NO:29 (GenBank Accession No. AF461684.1), a sigma-3 polypeptide having one or more amino acid modifications, wherein the one or more amino acid modifications are selected from the group consisting of a Leu at residue 14, a Lys at residue 198, or a combination thereof, numbered relative to SEQ ID NO:25 (GenBank Accession No. K02739), wherein when the amino acid sequence comprises a Leu at residue 14, the amino acid sequence further comprises at least one additional modification in the amino acid sequence, and a sigma-2 polypeptide.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 95.0
- Lexical Diversity: 1.73333
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14179840', '12848684', '12046095', '11997537', '15246109']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7751657524475397
- 35 USC 102 Novelty (BERT): 0.6108529981153735
- Combined Prediction Score: 0.7587344770143231
- Mean Citation Score: 412.15102800000005
- Max Citation Score: 525.06976
- Similarity Product: 512.0860226681708

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test