PATENT CLAIM ANALYSIS

Application Number: 16175206
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "384000"]

Abstract:
The invention provides novel compounds having the general formula I: wherein R 1 , R B1 , R B2 , n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Claim (Index 2):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein the A ring and the B ring together are selected from the group consisting of: or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is selected from the group consisting of C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 1 -C 6  hydroxyalkyl, C 1 -C 6  cyanoalkyl, C 3 -C 6  cycloalkyl-C 1 -C 3  alkyl, C 1 -C 6  alkyl-N(R 2 ) 2 , C 1 -C 6  alkoxy-C 1 -C 6  alkyl, C 1 -C 6  haloalkoxy-C 1 -C 6  alkyl, phenyl, benzyl, difluoro(phenyl)methyl, 4 to 6 membered heterocyclyl, 5 to 6 membered heteroaryl, and CH 2 -(5 to 6 membered heteroaryl); wherein:\n when R 1  is phenyl, benzyl, difluoro(phenyl)methyl, 5 to 6 membered heteroaryl or CH 2 -(5 to 6 membered heteroaryl), the phenyl or heteroaryl moiety of R 1  is optionally substituted by one or two substituents independently selected from the group consisting of halogen, C 1 -C 6  alkyl, hydroxyl, hydroxymethyl, methoxymethyl, cyano, trifluoromethyl, difluoromethoxy and trifluoromethoxy; \n when R 1  is cycloalkyl the cycloalkyl is optionally substituted by one, two or three substituents independently selected from the group consisting of fluoro, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, hydroxyl, C 1 -C 6  hydroxyalkyl or cyano; \n \n n is 1 or 2; \n each R 2  is independently selected from the group consisting of C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, and C 1 -C 6  haloalkyl; or two R 2  together with the nitrogen atom to which they are both attached form a 4-6 membered heterocyclic ring;\n R 3a  is hydrogen and R 3b , when p is 2, R B1  is independently R 3a  and R 3b  and each R 3a  and R 3b , when present, is/are independently is selected from the group consisting of halogen, deutero, hydroxyl, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  thioalkyl, C 1 -C 6  alkyl-N(R 2 ) 2 , and cyano; or \n R 3a  and R 3b  are-independently is selected from the group consisting of halogen, deutero, hydroxyl, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  thioalkyl, C 1 -C 6  alkyl-N(R 2 ) 2 , and cyano; or R 3a  and R 3b  together with the atoms to which they are attached form a bridged or spirocyclic ring; and \n wherein when q is 1, R B2  is R 4  and R 4  is selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  thioalkyl, C 1 -C 6  alkyl-N(R 2 ) 2 , phenyl, benzyl, CH 2 \u2014(C 3 -C 6  cycloalkyl), CH 2 CH 2 \u2014(C 3 -C 6  cycloalkyl), CH 2 -(4 to 6 membered heterocyclyl), CH 2 CH 2 -(4 to 6 membered heterocyclyl), 5 to 6 membered heteroaryl, and CH 2 -(5 to 6 membered heteroaryl);\n wherein when R 4  is phenyl, heteroaryl or benzyl the phenyl or heteroaryl ring is optionally substituted by 1 to 3 substituents selected from the group consisting of halogen, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 1 -C 4  alkoxy, C 1 -C 4  haloalkoxy, and cyano.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 97.0
- Lexical Diversity: 1.48571
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12845045', '13002487', '11060463', '13725407', '14533358']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8010479660799614
- 35 USC 102 Novelty (BERT): 0.5317615591464452
- Combined Prediction Score: 0.7741193253866099
- Mean Citation Score: 326.0833320000001
- Max Citation Score: 345.5191
- Similarity Product: 259.5752702908516

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test