PATENT CLAIM ANALYSIS

Application Number: 15749706
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "303000"]

Abstract:
6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Claim (Index 57):
A compound, or a pharmaceutically acceptable salt thereof, of Formula I: wherein: R 1  and R 4  are independently selected from the group consisting of H and halide; R 3  is selected from the group consisting of -heteroaryl optionally substituted with 1-4 R 6  and -heterocyclyl optionally substituted with 1-10 R 7 ; R 5  is selected from the group consisting of H, -heteroaryl optionally substituted with 1-4 R 8 , -heterocyclyl optionally substituted with 1-10 R 9 , and -aryl optionally substituted with 1-5 R 10 ; each R 6  is independently selected from the group consisting of halide, \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), \u2014(C 2-6  alkynyl), \u2014(C 1-4  alkylene) p heterocyclyl optionally substituted with 1-10 R 11 , \u2014(C 2-4  alkenylene) p heterocyclyl optionally substituted with 1-10 R 11 , \u2014(C 2-4  alkynylene) p heterocyclyl optionally substituted with 1-10 R 11 , \u2014(C 1-4  alkylene) p carbocyclyl optionally substituted with 1-12 R 12 , \u2014(C 2-4  alkenylene) p carbocyclyl optionally substituted with 1-12 R 12 , \u2014(C 2-4  alkynylene) p carbocyclyl optionally substituted with 1-12 R 12 , \u2014(C 1-4  alkylene) p aryl optionally substituted with 1-5 R 13 , \u2014(C 2-4  alkenylene) p aryl optionally substituted with 1-5 R 3 , \u2014(C 2-4  alkynylene) p aryl optionally substituted with 1-5 R 3 , \u2014NHC(\u2550O)R 14 , \u2014NR 15 R 16 , \u2014(C 1-6  alkylene)NR 17 R 18 , \u2014(C 2-6  alkenylene)NR 17 R 18 , \u2014(C 2-6  alkynylene)NR 17 R 18 , and \u2014(C 1-4  alkylene) p OR 24 ; each R 7  is independently selected from the group consisting of \u2014(C 1-4  alkyl), \u2014(C 2-4  alkenyl), \u2014(C 2-4  alkynyl), halide, \u2014CF 3 , and \u2014CN; each R 8  is independently selected from the group consisting of \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), \u2014(C 2-6  alkynyl), halide, \u2014CF 3 , \u2014OCH 3 , \u2014CN, and \u2014C(\u2550O)R 19 ; each R 9  is independently selected from the group consisting of \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), \u2014(C 2-6  alkynyl), halide, \u2014CF 3 , \u2014CN, and \u2014OCH 3 ; each R 10  is independently selected from the group consisting of \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), \u2014(C 2-6  alkynyl), halide, \u2014CF 3 , \u2014CN, \u2014(C 1-6  alkylene) p NHSO 2 R 19 , \u2014(C 2-6  alkenylene) p NHSO 2 R 19 , \u2014(C 2-6  alkynylene) p NHSO 2 R 19 , \u2014NR 15 (C 1-6  alkylene)NR 15 R 16 , \u2014NR 15 (C 2-6  alkenylene)NR 15 R 16 , \u2014NR 15 (C 2-6  alkynylene)NR 15 R 16 , \u2014(C 1-6  alkylene) p NR 15 R 16 , \u2014(C 2-6  alkenylene) p NR 15 R 16 , \u2014(C 2-6  alkynylene) p NR 15 R 16 , and \u2014OR 27 ; each R 11  is independently selected from the group consisting of amino, \u2014(C 1-4  alkyl), \u2014(C 2-4  alkenyl), \u2014(C 2-4  alkynyl), halide, \u2014CF 3 , and \u2014CN; each R 12  is independently selected from the group consisting of \u2014(C 1-4  alkyl), \u2014(C 2-4  alkenyl), \u2014(C 2-4  alkynyl), halide, \u2014CF 3 , and \u2014CN; each R 13  is independently selected from the group consisting of \u2014(C 1-4  alkyl), \u2014(C 2-4  alkenyl), \u2014(C 2-4  alkynyl), halide, \u2014CF 3 , and \u2014CN; each R 14  is independently selected from the group consisting of \u2014(C 1-9  alkyl), \u2014(C 1-4  haloalkyl), \u2014(C 2-9  alkenyl), \u2014(C 2-9  alkynyl), -heteroaryl optionally substituted with 1-4 R 20 , -aryl optionally substituted with 1-5 R 21 , \u2014CH 2 aryl optionally substituted with 1-5 R 21 , -carbocyclyl optionally substituted with 1-12 R 22 , \u2014CH 2 carbocyclyl optionally substituted with 1-12 R 22 , \u2014(C 1-4  alkylene) p NR 25 R 26 , \u2014(C 2-4  alkenylene) p NR 25 R 26 , \u2014(C 2-4  alkynylene) p NR 25 R 26 , -heterocyclyl optionally substituted with 1-10 R 23 , and \u2014CH 2 heterocyclyl optionally substituted with 1-10 R 23 ; each R 15  is independently selected from the group consisting of H, \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), and \u2014(C 2-6  alkynyl); each R 16  is independently selected from the group consisting of H, \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), \u2014(C 2-6  alkynyl), \u2014CH 2 aryl optionally substituted with 1-5 R 21 , and \u2014CH 2 carbocyclyl optionally substituted with 1-12 R 22 ; each R 17  is independently selected from the group consisting of H, \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), and \u2014(C 2-6  alkynyl); each R 18  is independently selected from the group consisting of H, \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), \u2014(C 2-6  alkynyl), \u2014CH 2 aryl optionally substituted with 1-5 R 21 , and \u2014CH 2 carbocyclyl optionally substituted with 1-12 R 22 ; each R 19  is independently selected from the group consisting of \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), and \u2014(C 2-6  alkynyl); each R 20  is independently selected from the group consisting of \u2014(C 1 -4 alkyl), \u2014(C 2-4  alkenyl), \u2014(C 2-4  alkynyl), halide, \u2014CF 3 , and \u2014CN; each R 21  is independently selected from the group consisting of \u2014(C 1-4  alkyl), \u2014(C 2-4  alkenyl), \u2014(C 2-4  alkynyl), halide, \u2014CF 3 , and \u2014CN; each R 22  is independently selected from the group consisting of \u2014(C 1-4  alkyl), \u2014(C 2-4  alkenyl), \u2014(C 2-4  alkynyl), halide, \u2014CF 3 , and \u2014CN; each R 23  is independently selected from the group consisting of \u2014(C 1-4  alkyl), \u2014(C 2-4  alkenyl), \u2014(C 2-4  alkynyl), halide, \u2014CF 3 , and \u2014CN; R 24  is selected from the group consisting of H, \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), \u2014(C 2-6  alkynyl), \u2014(C 1-4  alkylene) p heterocyclyl optionally substituted with 1-10 R 23 , \u2014(C 2-4  alkenylene) p heterocyclyl optionally substituted with 1-10 R 23 , \u2014(C 2-4  alkynylene) p heterocyclyl optionally substituted with 1-10 R 23 , \u2014(C 1-4  alkylene) p carbocyclyl optionally substituted with 1-12 R 22 , \u2014(C 2-4  alkenylene) p carbocyclyl optionally substituted with 1-12 R 22 , \u2014(C 2-4  alkynylene) p carbocyclyl optionally substituted with 1-12 R 22 , \u2014(C 1-4  alkylene) p aryl optionally substituted with 1-5 R 21 , \u2014(C 2-4  alkenylene) p aryl optionally substituted with 1-5 R 21 , \u2014(C 2-4  alkynylene) p aryl optionally substituted with 1-5 R 21 , \u2014(C 1-6  alkylene) p NR 25 R 26 , \u2014(C 2-4  alkenylene) p NR 25 R 26 , and \u2014(C 2-4  alkynylene) p NR 25 R 26 ; each R 25  is independently selected from the group consisting of H, \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), and \u2014(C 2-6  alkynyl); each R 26  is independently selected from the group consisting of H, \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), and \u2014(C 2-6  alkynyl); R 27  is selected from the group consisting of H, \u2014(C 1-6  alkyl), \u2014(C 2-6  alkenyl), \u2014(C 2-6  alkynyl), \u2014(C 1-4  alkylene) p heterocyclyl optionally substituted with 1-10 R 23 , \u2014(C 2-4  alkenylene) p heterocyclyl optionally substituted with 1-10 R 23 , \u2014(C 2-4  alkynylene)heterocyclyl optionally substituted with 1-10 R 23 , \u2014(C 1-6  alkylene) p NR 25 R 26 , \u2014(C 2-6  alkenylene)NR 25 R 26 , and \u2014(C 2-6  alkynylene)NR 25 R 26 ; and each p is independently an integer of 0 or 1.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.62319
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15749713', '15749727', '15749608', '15749701', '15749721']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8533701383242092
- 35 USC 102 Novelty (BERT): 0.6307445000957762
- Combined Prediction Score: 0.8311075745013659
- Mean Citation Score: 570.7420480000002
- Max Citation Score: 576.4082599999998
- Similarity Product: 571.0849094847869

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test