PATENT CLAIM ANALYSIS

Application Number: 16215153
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["435", "007200"]

Abstract:
A method for evaluating a biological material for unassociated virus-size particles having a particular epitope uses a fluorescent antibody stain specific for binding with the epitope and a fluid sample with the virus-size particles and fluorescent antibody stain is subjected to flow cytometry with identification of fluorescent emission detection events indicative of passage through a flow cell of a flow cytometer of unassociated labeled particles of virus size including such a virus-size particle and fluorescent antibody stain.

Claim (Index 29):
A method for evaluating a biological material sample for unassociated virus-size particles having a particular epitope, the method comprising:\n subjecting to flow cytometry a fluid sample comprising at least a portion of the biological material sample, wherein the fluid sample comprises a fluorescent antibody stain capable of binding, directly or indirectly, with the particular epitope, the fluorescent antibody stain having a fluorescent emission response when subjected to an excitation radiation, the flow cytometry comprising:\n flowing the fluid sample through a flow cell of a flow cytometer; \n subjecting the fluid sample flowing through the flow cell to the excitation radiation causing the fluorescent emission response from the fluorescent antibody stain; and \n detecting radiation from the flow cell within a wavelength range of the fluorescent emission response and evaluating the detected radiation within the wavelength range to identify fluorescent emission detection events indicative of passage through the flow cell of unassociated labeled particles of virus size, each said unassociated labeled particle including a said virus-size particle with the epitope and the fluorescent antibody stain; and \n wherein, the fluorescent antibody stain is a first fluorescent stain and the fluid sample comprises a second fluorescent stain having a second fluorescent emission response, different than the fluorescent emission response of the first fluorescent stain, caused by the excitation radiation, and wherein the second fluorescent stain comprises a fluorescent nucleic acid stain not specific to particle type.

Metadata:
- Claim Count in Document: 60.0
- Percentile: 98.0
- Lexical Diversity: 1.69565
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15558107', '15713314', '15713154', '15123544', '16206350']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7024298126615918
- 35 USC 102 Novelty (BERT): 0.6558725960248326
- Combined Prediction Score: 0.6977740909979159
- Mean Citation Score: 551.579896
- Max Citation Score: 637.5039
- Similarity Product: 624.9320456869482

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test