PATENT CLAIM ANALYSIS

Application Number: 16048147
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-03
Patent Classification: ["424", "093200"]

Abstract:
Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

Claim (Index 4):
The method of  claim 2 , wherein (1) the bacterium belongs to genus  Bacillus , (2) the flagellin gene promoter is a modified  Bacillus  hag promoter comprising one or more genetic modifications of the CsrA BS1 binding site and/or the CsrA BS2 binding site, (3) the sigma factor is SigD and (4) the SigD repressor is FlgM.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 95.0
- Lexical Diversity: 1.68627
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14371557', '13819773', '12775306', '14084230', '14718612']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6973470010395608
- 35 USC 102 Novelty (BERT): 0.5002074960565193
- Combined Prediction Score: 0.6776330505412567
- Mean Citation Score: 164.91083999999995
- Max Citation Score: 170.46228
- Similarity Product: 105.75519673244476

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test