PATENT CLAIM ANALYSIS

Application Number: 16223845
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["514", "338000"]

Abstract:
The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

Claim (Index 12):
The compound according to  claim 1  selected from the group consisting of\n 1 N-[(2R,3S)-2-(3-chlorophenyl)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-pyrrolidin-3-yl]-2,2-difluoropropanamide \n 2 2,2-difluoro-N-[rac-(2R,3S)-2-(2,4-difluorophenyl)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-pyrrolidin-3-yl]propanamide \n 3 2,2-difluoro-N-[rac-(2R,3S)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-pyrrolidin-3-yl]propanamide \n 4 2,2-difluoro-N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 5 2,2-difluoro-N-[(2R,3S)-2-(3-fluorophenyl)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-pyrrolidin-3-yl]propanamide \n 6 2,2-difluoro-N-[(2R,3S)-2-(2-fluorophenyl)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-pyrrolidin-3-yl]propanamide \n 7 2,2-difluoro-N-[rac-(2R,3S)-5-oxo-2-phenyl-1-[1-(3-pyridyl)indazol-5-yl]pyrrolidin-3-yl]propanamide \n 9 2,2-difluoro-N-[rac-(2R,3S)-1-[1-(5-fluoro-2-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 13 5-methyl-N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]thiazole-2-carboxamide \n 15 2,2-difluoro-N-[(2R,3S)-2-(4-fluoro-3-methoxy-phenyl)-1-[1-(1-methyl-6-oxo-3-pyridyl)-indazol-5-yl]-5-oxo-pyrrolidin-3-yl]propanamide \n 17 2,2-difluoro-N-[(2R,3S)-2-(4-fluorophenyl)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-pyrrolidin-3-yl]propanamide \n 18 1-fluoro-N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]cyclopropanecarboxamide \n 22 2,2-difluoro-N-[rac-(2R,3S)-1-[1-(6-methoxy-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 23 2,2-difluoro-N-[rac-(2R,3S)-5-oxo-2-phenyl-1-[1-(4-pyridyl)indazol-5-yl]pyrrolidin-3-yl]propanamide \n 24 2,2-difluoro-N-[rac-(2R,3S)-1-[1-(6-methyl-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 25 2,2-difluoro-N-[rac-(2R,3S)-1-[1-(2-methyl-4-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 26 1-methyl-N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]cyclopropanecarboxamide \n 27 2,2-difluoro-N-[rac-(2R,3S)-1-[1-(2-methoxy-4-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 31 2,2-difluoro-N-[rac-(2R,3S)-1-[1-[(2-methoxy-4-pyridyl)methyl]indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 32 2,2-difluoro-N-[rac-(2R,3S)-1-[1-[(1-methylpyrazol-3-yl)methyl]indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 33 2,2-difluoro-N-[rac-(2R,3S)-1-[1-[(6-methoxy-3-pyridyl)methyl]indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 34 2,2-difluoro-N-[rac-(2R,3S)-1-[1-[(1-methyl-6-oxo-3-pyridyl)methyl]indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 35 2,2-difluoro-N-[rac-(2R,3S)-1-[1-[1-(cyclopropanecarbonyl)-4-piperidyl]indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 38 2,2-difluoro-N-[rac-(2R,3S)-1-[1-[(1-methyl-2-oxo-4-pyridyl)methyl]indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 39 N-[(2R,3S)-2-(2-fluorophenyl)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-pyrrolidin-3-yl]cyclopropanecarboxamide \n 40 N-[rac-(2R,3S)-1-[1-[(2-methoxy-4-pyridyl)methyl]indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]cyclopropanecarboxamide \n 41 N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-2-(o-tolyl)-5-oxo-pyrrolidin-3-yl]cyclopropanecarboxamide \n 42 2,2-difluoro-N-[(2R,3S)-2-(2-methoxy-4-pyridyl)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-pyrrolidin-3-yl]propanamide \n 43 2,2-difluoro-N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-2-(o-tolyl)-5-oxo-pyrrolidin-3-yl]propanamide \n 44 N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]thiazole-4-carboxamide \n 45 1-methyl-N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]pyrazole-3-carboxamide \n 46 2,2-difluoro-N-[rac-(2R,3S)-1-[1-(1-methylpyrazol-4-yl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 47 2,2-difluoro-N-[rac-(2R,3S)-1-[1-(5-fluoropyrimidin-2-yl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]propanamide \n 48 (R)\u2014N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]tetrahydrofuran-2-carboxamide \n 49 N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]oxazole-2-carboxamide \n 50 N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]oxazole-4-carboxamide \n 51 5-methyl-N-[(2R,3S)-1-[1-(1-methyl-6-oxo-3-pyridyl)indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]-1,2,4-oxadiazole-3-carboxamide \n in the form of the free compound or a physiologically acceptable salt thereof.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 98.0
- Lexical Diversity: 1.19444
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14409133', '14383096', '14112581', '13272079', '12558426']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7992102260738653
- 35 USC 102 Novelty (BERT): 0.5233258024036662
- Combined Prediction Score: 0.7716217837068453
- Mean Citation Score: 311.029172
- Max Citation Score: 328.6948
- Similarity Product: 280.22164971973893

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test