PATENT CLAIM ANALYSIS

Application Number: 15957686
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "001000"]

Abstract:
Disclosed herein are embodiments of a method for using estrogenic compounds to manipulate the bacterial composition of vaginal communities of female subjects. The method may include titrating a dose of an estrogenic compound to provide a female subject with a personalized effective dose, such as a minimum effective dose, sufficient to attain and/or maintain one or more determined target values of a relative abundance of vaginal  Lactobacillus  in the vaginal microbiota, an absolute abundance of vaginal  Lactobacillus  in the vaginal microbiota, a vaginal pH, a vaginal lactic acid concentration, or any combination thereof.

Claim (Index 4):
The method of  claim 1 , further comprising:\n obtaining a subsequent vaginal sample from the female subject a period of time after beginning administration of the one or more effective doses of the estrogenic compound, the subsequent vaginal sample comprising a subsequent vaginal microbiota; obtaining subsequent analysis results of the subsequent vaginal sample, the subsequent analysis results comprising a relative abundance of  Lactobacillus  in the subsequent vaginal microbiota, an absolute abundance of  Lactobacillus  in the subsequent vaginal microbiota, a subsequent vaginal pH, a subsequent vaginal lactic acid concentration, or any combination thereof; adjusting, based at least in part on the subsequent analysis results, the effective dose of the estrogenic compound to provide an adjusted effective dose of the estrogenic compound for administration to the female subject; and administering one or more adjusted effective doses of the estrogenic compound to the female subject over an effective period of time, in response to which the one or more determined target values of the relative abundance of vaginal  Lactobacillus  in the vaginal microbiota, the absolute abundance of vaginal  Lactobacillus  in the vaginal microbiota, the vaginal pH, the vaginal lactic acid concentration, or any combination thereof is attained and/or maintained.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 91.0
- Lexical Diversity: 1.68333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15536297', '11331856', '15155675', '15740807', '14496737']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7160794609325687
- 35 USC 102 Novelty (BERT): 0.5036191752243482
- Combined Prediction Score: 0.6948334323617467
- Mean Citation Score: 232.489466
- Max Citation Score: 243.5908
- Similarity Product: 179.03762985970974

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test