PATENT CLAIM ANALYSIS

Application Number: 16186333
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "176000"]

Abstract:
This invention provides amine-linked C 3 -glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.

Claim (Index 27):
The compound of  claim 26 , wherein the Linker is selected from: wherein: X 1  and X 2  are independently selected from bond, NH, NR 25 , CH 2 , CHR 25 , C(R 25 ) 2 , O, and S; R 20 , R 21 , R 22 , R 23 , and R 24  are independently selected from bond, alkyl, \u2014C(O)\u2014 \u2014C(O)O\u2014, \u2014OC(O)\u2014, \u2014C(O)alkyl, \u2014C(O)Oalkyl, \u2014C(S)\u2014, \u2014SO 2 \u2014, \u2014S(O)\u2014, \u2014C(S)\u2014, \u2014C(O)NH\u2014, \u2014NHC(O)\u2014, \u2014N(alkyl)C(O)\u2014, \u2014C(O)N(alkyl)-, \u2014O\u2014, \u2014S\u2014, \u2014NH\u2014, \u2014N(alkyl)-, \u2014C(\u2014O\u2014R 26 )H\u2014, \u2014C(\u2014NHR 25 )H\u2014, \u2014C(\u2014NH 2 )H\u2014, \u2014C(\u2014NR 25 2 )H\u2014, \u2014C(\u2014O\u2014R 26 )alkyl-, \u2014C(\u2014NHR 25 )alkyl-, \u2014C(\u2014NH 2 )alkyl-, \u2014C(\u2014NR 25 2 )alkyl-, -alkyl(R 27 )-alkyl(R 28 )\u2014, \u2014CR 27 R 28 \u2014, \u2014P(O)(OR 26 )O\u2014, \u2014P(O)(OR 26 )\u2014, \u2014NHC(O)NH\u2014, \u2014N(R 25 )C(O)N(R 25 )\u2014, \u2014N(H)C(O)N(R 25 )\u2014, polyethylene glycol, poly(lactic-co-glycolic acid), alkene, haloalkyl, alkoxy, and alkyne; R 25  is selected at each instance from: alkyl, \u2014C(O)H, \u2014C(O)OH, \u2014C(O)alkyl, \u2014C(O)Oalkyl, alkenyl, and alkynyl; R 26  is hydrogen, alkyl, silane, arylalkyl, heteroarylalkyl, alkene, and alkyne; and R 27  and R 28  are independently selected from hydrogen, alkyl, amine, or together with the carbon atom to which they are attached, form C(O), C(S), C\u2550CH 2 , a C 3 -C 6  spirocarbocycle, or a 4-, 5-, or 6-membered spiroheterocycle comprising 1 or 2 heteroatoms selected from N and O.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 98.0
- Lexical Diversity: 1.22222
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16186339', '16186334', '16163254', '15148262', '16167091']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7677964127474808
- 35 USC 102 Novelty (BERT): 0.6240368578622532
- Combined Prediction Score: 0.7534204572589581
- Mean Citation Score: 448.087808
- Max Citation Score: 633.1144400000002
- Similarity Product: 493.1695722583939

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test