PATENT CLAIM ANALYSIS

Application Number: 16032743
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "210210"]

Abstract:
This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Claim (Index 77):
A method for inhibiting a TAM kinase, said method comprising: contacting the TAM kinase with a compound having Formula IVa, IVb, IVc, IVd, or IVe: or a pharmaceutically acceptable salt thereof, wherein\n R 1  is H, halo, CN, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , NR c1 R d1 , NR c1 OR d1 , NR c1 C(O)R b1 , NR c1 C(O)OR b1 , NR c1 C(O)NR c1 R d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , S(O) 2 NR c1 R d1 , C 3-7  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C 3-7  cycloalkyl-C 1-3  alkylene, phenyl-C 1-3  alkylene, 5-6 membered heteroaryl-C 1-3  alkylene, or 4-6 membered heterocycloalkyl-C 1-3  alkylene; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, C 3-7  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C 3-7  cycloalkyl-C 1-3  alkylene, phenyl-C 1-3  alkylene, 5-6 membered heteroaryl-C 1-3  alkylene, and 4-6 membered heterocycloalkyl-C 13  alkylene are each optionally substituted with 1, 2, 3, or 4 independently selected R 11  groups; \n R 2  is H, halo, OH, CN, C 1-4  alkyl, C 1-4  haloalkyl, C 1-6  alkoxy, C 1-4  haloalkoxy, amino, C 1-6  alkylamine, or di(C 1-6  alkyl)amino; \n each R 7  is independently selected from halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, CN, NO 2 , Cy, \u2014C 1-4  alkylene-Cy, OR a , SR a , C(O)R b , C(O)NR c R d , C(O)OR a , OC(O)R b , OC(O)NR c R d , NR c R d , NR c OR d , NR c C(O)R b , NR c C(O)OR b , NR c C(O)NR c R d , C(\u2550NR e )R b , C(\u2550NR e )NR c R d , NR c C(\u2550NR e )NR c R d , NR c S(O)R b , NR c S(O) 2 R b , NR c S(O) 2 NR c R d , S(O)R b , S(O)NR c R d , S(O) 2 R b , and S(O) 2 NR c R d ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-4  haloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R 8  groups; \n each R 8  is independently selected from halo, CN, NO 2 , C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy 2 , \u2014C 1-4  alkylene-Cy 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , NR c2 R d2 , NR c2 OR d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2 , C(\u2550NR e )R b2 , C(\u2550NR e )NR c2 R d2 , NR c2 C(\u2550NR e )NR c2 R d2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R b2 , NR c2 S(O) 2 NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 NR c2 R d2 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-4  haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R g  groups; \n Z is C 1-6  alkyl, C 1-6  haloalkyl, or \u2014C 1-6  alkylene-Z 1 ; \n Z 1  is CN, Cy 3 , OR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R d3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)OR b3 , NR 3 C(O)NR c3 R d3 , NR c3  S(O)R b3 , NR c3  S(O) 2 R b3 , NR c3 S(O) 2 NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , or S(O) 2 NR c3 R d3 ; \n each R 11  is independently selected from OH, NO 2 , CN, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, cyano-C 1-3  alkyl, HO\u2014C 1-3  alkyl, amino, C 1-6  alkylamino, di(C 1-6  alkyl)amino, thio, C 1-6  alkylthio, C 1-6  alkylsulfinyl, C 1-6  alkylsulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, carboxy, C 1-6  alkylcarbonyl, C 1-6  alkoxycarbonyl, C 1-6  alkylcarbonylamino, C 1-6  alkylsulfonylamino, aminosulfonyl, C 1-6  alkylaminosulfonyl, di(C 1-6  alkyl)aminosulfonyl, aminosulfonylamino, C 1-6  alkylaminosulfonylamino, di(C 1-6  alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6  alkylaminocarbonylamino, di(C 1-6  alkyl)aminocarbonylamino, C 3-7  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C 3-7  cycloalkyl-C 1-3  alkylene, phenyl-C 1-3  alkylene, 5-6 membered heteroaryl-C 1-3  alkylene, and 4-6 membered heterocycloalkyl-C 1-3  alkylene; wherein said C 1-6  alkyl, C 3-7  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C 3-7  cycloalkyl-C 1-3  alkylene, phenyl-C 1-3  alkylene, 5-6 membered heteroaryl-C 1-3  alkylene, and 4-6 membered heterocycloalkyl-C 1-3  alkylene are each optionally substituted with 1, 2, 3, or 4 groups independently selected from OH, CN, halo, C 1-4  alkyl, C 1-3  haloalkyl, C 1-4  alkoxy, C 1-3  haloalkoxy, cyano-C 1-3  alkyl, HO\u2014C 1-3  alkyl, amino, C 1-4  alkylamino, di(C 1-4  alkyl)amino, C 1-4  alkylsulfinyl, C 1-4  alkylsulfonyl, carbamyl, C 1-4  alkylcarbamyl, di(C 1-4  alkyl)carbamyl, carboxy, C 1-4  alkylcarbonyl, C 1-4  alkoxycarbonyl, C 1-4  alkylcarbonylamino, C 1-4  alkylsulfonylamino, aminosulfonyl, C 1-4  alkylaminosulfonyl, and di(C 1-4  alkyl)aminosulfonyl; \n each Cy is independently selected from 3-12 membered cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, and 4-12 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected R 8  groups; \n each Cy 1  is independently selected from 3-7 membered cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected R 11  groups; \n each Cy 2  is independently selected from 3-7 membered cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected R g  groups; \n each Cy 3  is independently selected from 3-7 membered cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 groups independently selected from halo, OH, CN, C 1-3  alkyl, C 1-3  haloalkyl, C 1-3  alkoxy, C 1-3  haloalkoxy, amino, C 1-3  alkylamine, and di(C 1-3  alkyl)amino; \n each R a , R c , and R d  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy, and \u2014C 1-4  alkylene-Cy; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-4  haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 8  groups; \n each R b  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy, and \u2014C 1-4  alkylene-Cy; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-4  haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 8  groups; alternatively, any R c  and R d  attached to the same N atom, together with the N atom to which they are attached, form a 4-6 membered heterocycloalkyl group or a 5-6 membered heteroaryl group, each optionally substituted with 1, 2, or 3 independently selected R 8  groups; \n each R e  is independently selected from H, CN, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkylthio, C 1-6  alkylsulfonyl, C 1-6  alkylcarbonyl, C 1-6  alkylaminosulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, aminosulfonyl, C 1-6  alkylaminosulfonyl, and di(C 1-6  alkyl)aminosulfonyl; \n R a1 , R c1 , and R d1  are each independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy 1 , and \u2014C 1-4  alkylene-Cy 1 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-4  haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 11  groups; \n R b1  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy 1 , and \u2014C 1-4  alkylene-Cy 1 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-4  haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 11  groups; or alternatively, any R c1  and R d1  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 independently selected R 11  groups; \n each R a2 , R c2 , and R d2  are independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy 2 , and \u2014C 1-4  alkylene-Cy 2 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-4  haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R g  groups; \n each R b2  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy 2 , and \u2014C 1-4  alkylene-Cy 2 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-4  haloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R groups; or alternatively, any R c2  and R d2  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 independently selected R g  groups; \n R a3 , R c3 , and R d3  are each independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy 3 , and \u2014C 1-4  alkylene-Cy 3 ; \n R b3  is selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, Cy 3 , and \u2014C 1-4  alkylene-Cy 3 ; and \n each R g  is independently selected from OH, NO 2 , CN, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, cyano-C 1-3  alkyl, HO\u2014C 1-3  alkyl, amino, C 1-6  alkylamino, di(C 1-6  alkyl)amino, thio, C 1-6  alkylthio, C 1-6  alkylsulfinyl, C 1-6  alkylsulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, carboxy, C 1-6  alkylcarbonyl, C 1-6  alkoxycarbonyl, C 1-6  alkylcarbonylamino, C 1-6  alkylsulfonylamino, aminosulfonyl, C 1-6  alkylaminosulfonyl, di(C 1-6  alkyl)aminosulfonyl, aminosulfonylamino, C 1-6  alkylaminosulfonylamino, di(C 1-6  alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6  alkylaminocarbonylamino, and di(C 1-6  alkyl)aminocarbonylamino.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 95.0
- Lexical Diversity: 1.13793
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15247499', '15971017', '15234690', '15624850', '15151259']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7934488619072594
- 35 USC 102 Novelty (BERT): 0.6167248846200705
- Combined Prediction Score: 0.7757764641785405
- Mean Citation Score: 507.6831120000001
- Max Citation Score: 627.3497
- Similarity Product: 473.9269249576926

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test