PATENT CLAIM ANALYSIS

Application Number: 16007848
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["424", "139100"]

Abstract:
The present invention provides antibodies and antigen-binding fragments of antibodies that bind to leptin receptor (LEPR), and methods of using the same. According to certain embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that bind LEPR and activate LEPR signaling. In other embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that bind to LEPR and enhance sensitization of LEPR to an antigen. In certain embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that bind LEPR in the presence and absence of leptin. In certain embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that induce signaling in cells expressing LEPR mutants that otherwise exhibit defective or impaired signaling in the presence of leptin. The antibodies and antigen-binding fragments of the present invention are useful for the treatment of lipodystrophies and other diseases and disorders associated with or caused by leptin deficiency or leptin resistance.

Claim (Index 50):
The antibody of  claim 36  in combination with recombinant human leptin, alirocumab, evolocumab, bococizumab, lodelcizumab, ralpancizumab, atorvastatin, rosuvastatin, cerivastatin, pitavastatin, fluvastatin, simvastatin, lovastatin, pravastatin, ezetimibe, insulin, metformin, dapaglifozin, canaglifozin, empagliflozin, extendin-4, exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, an anti-GCG antibody, an anti-GCGR antibody, an anti-ANGPTL3 antibody, an anti-ANGPTL4 antibody, anti-ANGPTL8 antibody, phentermine, orlistat, topiramate, bupropion, topiramate and phentermine, bupropion and naltrexone, bupropion and zonisamide, pramlintide and metrelepin, lorcaserin, cetilistat, tesofensine or velneperit.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 94.0
- Lexical Diversity: 2.73333
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16007812', '15807426', '15651387', '14603808', '14603776']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8042444279643506
- 35 USC 102 Novelty (BERT): 0.6495551125139648
- Combined Prediction Score: 0.7887754964193121
- Mean Citation Score: 604.681496
- Max Citation Score: 824.3704
- Similarity Product: 559.4720108484745

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test