PATENT CLAIM ANALYSIS

Application Number: 15756476
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "266300"]

Abstract:
Provided are a type of compounds that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds and the compositions can improve lipid metabolism disorders by increasing high-density lipoprotein cholesterol in blood; in addition, the compounds and the compositions can also release nitric oxide, and reduce the onset risk of cardiovascular diseases by means of relaxing blood vessels, lowering blood pressure, inhibiting platelet adhesion and aggregation and maintaining vascular tension, and thus play an important role in preventing and treating the occurrence and development of cardiovascular diseases.

Claim (Index 1):
A compound of general formula (II), and a pharmaceutically acceptable salt or stereoisomer thereof:\n A-B \u2003\u2003(II) wherein A is a residue group of a small molecule compound for preventing and treating cardiovascular diseases, selected from the following groups: wherein R 1  is \u2014O\u2014; and R 0  is selected from the following groups: B is selected from:\n \u2014C(O)\u2014CH 2 \u2014NH\u2014C(O)\u2014Y 0 ; \u2014C(O)\u2014CH 2 \u2014NH\u2014C(O)\u2014Y; \u2014C(O)\u2014CH 2 \u2014CH 2 \u2014NH\u2014C(O)\u2014Y 0 ; \u2014C(O)\u2014CH 2 \u2014CH 2 \u2014NH\u2014C(O)\u2014Y; \n wherein Y 0  is \u2014R 5 \u2014Y, Y is \u2014T\u2014ONO 2 , \u2014T\u2014SNO, \u2014(CH 2 \u2014CH 2 ) r \u2014R 5 \u2014CH 2 \u2014CH 2 \u2014ONO 2 , wherein R 2  is H, a linear C 1-4  alkyl group, or a branched C 3-4  alkyl group; R 3  is \u2014CH\u2014 or a nitrogen atom; X is a fluorine atom or a chlorine atom; R 4  is a C 1-3  alkyl group; Rs 5  is \u2014O\u2014, \u2014S\u2014, \u2014NH\u2014, or a nitrogen atom substituted with a C 1-3  alkyl group; R 8  is a C 1-6  alkyl group, a C 1-6  alkyl group substituted with a C 1-3  alkyl group, a C 1-6  alkyl group substituted with a hydroxyl group, a C 1-6  alkyl group substituted with fluorine, a C 1-6  alkyl group substituted with deuterium, \u2014CH 2 \u2014R 10 , or \u2014CH 2 \u2014CH 2 \u2014R 10 , wherein R 10  is \u2014OH, \u2014O\u2014C 1-6  alkyl group, \u2014OCD 3 , \u2014C(O)\u2014T 2 , \u2014C(O)\u2014R 5 \u2014T 2 , \u2014OC(O)\u2014T 2 , \u2014R 5 \u2014C(O)R 5 -T 2 , \u2014NH 2 , \u2014C 6 H 5 , or an unsubstituted 5 or 6 membered heteroaryl ring having 1, 2 or 3 nitrogen atoms, or a substituted 5 or 6 membered heteroaryl ring having 1, 2 or 3 nitrogen atoms, wherein the substituted 5 or 6 membered heteroaryl ring is mono- or di-substituted with a group selected from the following substituents on any carbon atom: \u2014OH, \u2014O\u2014C 1-6  alkyl, \u2014OCD 3 , \u2014C(O)\u2014T 2 , \u2014C(O)\u2014R 5 \u2014T 2 , \u2014OC(O)\u2014T 2 , \u2014R 5 \u2014C(O)R 5 \u2014T 2 , \u2014NH 2 , \u2014C 1-6  alkyl, a C 1-6  alkyl group substituted with a hydroxyl group, a C 1-6  alkyl group substituted with fluorine, or a C 1-6  alkyl group substituted with deuterium; R 13  is H, C 1-4  alkyl, cyano, benzyl, nitro, p-nitrophenyl; R 14  is H, or R 8 ; T is a linear C 1-20  alkylene group, a branched C 3-20  alkylene group, or a C 1-20  alkylene group substituted with one or more substituents, wherein the substituent is hydroxyl, \u2014ONO 2 , or T 1 ; or a cycloalkylene group having 4 to 7 carbon atoms, the cycloalkylene group is optionally substituted with one or more linear C 1-10  alkyl chains or branched C 3-10  alkyl chains; U is a linear C 1-20  alkylene group or a branched C 3-20  alkylene group, wherein a hydrogen atom is optionally substituted with \u2014ONO 2  group; T 1  is an unsubstituted or substituted linear C 1-8  alkyl group, an unsubstituted or substituted branched C 3-10  alkyl group, an unsubstituted or substituted linear C 2-10  alkenyl group, an unsubstituted or substituted branched C 3-10  alkenyl group, an unsubstituted or substituted benzyl group, an unsubstituted or substituted phenyl group, a C 1-4  alkyl group substituted with an unsubstituted or substituted aryl group, an unsubstituted or substituted heteroaryl group, \u2014OC(O)\u2014(C 1-6  alkyl)\u2014ONO 2 , or \u2014O\u2014(C 1-6  alkyl)\u2014ONO 2 ; T 2  is an unsubstituted or substituted linear C 1-8  alkyl group, an unsubstituted or substituted branched C 3-10  alkyl group, an unsubstituted or substituted linear C 2-10  alkenyl group, an unsubstituted or substituted branched C 3-10  alkenyl group, an unsubstituted or substituted benzyl group, an unsubstituted or substituted phenyl group, a C 1-4  alkyl group substituted with an unsubstituted or substituted aryl group, an unsubstituted or substituted heteroaryl group; Y 1  is a linear C 1-20  alkylene group, a branched C 3-20  alkylene group, a linear C 2-20  alkenylene group, a branched C 3-20  alkenylene group; or a C 1-20  alkylene group substituted with one or more substituents, or C 2-20  alkenylene group substituted with one or more substituents, wherein the substituent is T 2 ; or a cycloalkylene group having 4 to 7 carbon atoms, the cycloalkylene group is optionally substituted with one or more linear C 1-10  alkyl chains or branched C 3-10  alkyl chains; particularly selected from the following groups:\n \u2014(CH 2 ) r \u2014, \u2014(CH 2 ) n \u2014Z\u2014(CH 2 ) r \u2014, \u2014CH 2 \u2014CH(CH 3 )\u2014(CH 2 ) r \u2014, \u2014CH 2 \u2014CH(CH 3 )\u2014(CH 2 ) r \u2014Z\u2014CH 2 \u2014, \u2014CH 2 \u2014CH(CH 3 )\u2014CH 2 \u2014Z\u2014(CH 2 ) r \u2014, \u2014CH 2 CH\u2550CHCH 2 \u2014, CH 2 CH\u2550CHCH 2 \u2014Z\u2014(CH 2 ) r \u2014, \n wherein Z is R 5 , and A is O, N, S and C; Y 2  is C 1-8  alkyl, phenyl, phenylsulfonyl, cyano, trifluoromethyl, C 1-8  alkoxy, or C 1-8  alkylnitrate groups; Y 4  is hydrogen, halogen, trifluoromethyl, C 1-8  alkoxy, C 1-8  alkyl, nitro, sulfonamido, amino, or cyano groups; Y 11  is and n is an integer from 0 to 4; m is an integer from 0 to 3; and r is an integer from 1 to 6.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 88.0
- Lexical Diversity: 1.62295
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13265060', '10718337', '14908898', '14942009', '10582131']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7170810670837456
- 35 USC 102 Novelty (BERT): 0.5595851621089059
- Combined Prediction Score: 0.7013314765862616
- Mean Citation Score: 382.305752
- Max Citation Score: 436.99478
- Similarity Product: 295.5450088107109

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test