PATENT CLAIM ANALYSIS

Application Number: 15915909
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["536", "025400"]

Abstract:
Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.

Claim (Index 6):
The composition of  claim 1 , wherein said crosslinker is selected from the group consisting of 1,4-cyclohexane dimethanol diglycidyl ether, neopentylglycol diglycidyl ether, 1,4-butanediol diglycidyl ether, ethylene glycol diglycidyl ether, polypropylene glycol diglycidyl ether, resorcinol diglycidyl ether, glycerol diglycidyl ether, polyethylene glycol diglycidyl ether), polymethyl methacrylate, polyethylene glycol methyl ether, polyethylene glycol diacrylate, polyethylene glycol diamine, Poly(2-hydroxyethyl methacrylate), Poly(D,L-lactide-co-glycolide), poly-lactic acid, poly-glycolic acid, Poly[(R)-3-hydroxybutyric acid], Poly(dimethylsiloxane), vinyl terminated, Poly(dimethylsiloxane), and diglycidyl ether.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 90.0
- Lexical Diversity: 1.57407
- Patent Class: 536.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15547173', '14113371', '10416381', '12708520', '15117164']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6489278017716926
- 35 USC 102 Novelty (BERT): 0.5012589114296273
- Combined Prediction Score: 0.6341609127374861
- Mean Citation Score: 207.053656
- Max Citation Score: 307.42685
- Similarity Product: 291.67441818906667

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test