PATENT CLAIM ANALYSIS

Application Number: 16179648
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["424", "186100"]

Abstract:
The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation of the parvoviral Rep78 protein is a suboptimal initiation codon that effects partial exon skipping upon expression in insect cells. The insect cell further comprises a second nucleotide sequence comprising at least one parvoviral (AAV) inverted terminal repeat (ITR) nucleotide sequence and a third nucleotide sequence comprising a sequences coding for the parvoviral capsid proteins.

Claim (Index 32):
The nucleic acid construct of  claim 21 , wherein the nucleic acid construct comprises a second nucleotide sequence comprising at least one parvoviral inverted terminal repeat (ITR) sequence and a third nucleotide sequence comprising at least one parvoviral Cap protein encoding sequence operably linked to an expression control sequence for expressing the at least one Cap protein in an insect cell.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 98.0
- Lexical Diversity: 1.68919
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15978669', '15424560', '14603469', '13945505', '12306239']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8665956801481859
- 35 USC 102 Novelty (BERT): 0.7021925026147539
- Combined Prediction Score: 0.8501553623948427
- Mean Citation Score: 845.6615740000003
- Max Citation Score: 881.4195
- Similarity Product: 715.0265892266929

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test