PATENT CLAIM ANALYSIS

Application Number: 15871017
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "400000"]

Abstract:
Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.

Claim (Index 1):
A method of treating chronic pain, the method comprising:\n administering to a subject in need thereof a mucoadhesive bioerodable drug delivery device, wherein the device is administered once or twice daily, wherein the device comprises: a bioerodable mucoadhesive layer comprising about 100 g to about 0.9 mg buprenorphine and buffered to a pH of between about 4.0 and about 6.0; and a backing layer buffered to a pH of between about 4.0 and about 4.8 and that does not include an opioid antagonist; wherein the device provides a steady-state Cmax of plasma buprenorphine concentration in a range between about 0.156 and about 0.364 ng/mL, wherein the subject is an opioid-experienced subject; and wherein the subject treated experiences mild or moderate common opioid adverse effects, or no common opioid adverse effects.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 1.13889
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13724959', '15198961', '15212912', '13184306', '13590094']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6758611919095463
- 35 USC 102 Novelty (BERT): 0.4709560019504829
- Combined Prediction Score: 0.65537067291364
- Mean Citation Score: 190.789204
- Max Citation Score: 227.24088
- Similarity Product: 222.4117517852354

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test