PATENT CLAIM ANALYSIS

Application Number: 15768388
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "300000"]

Abstract:
The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated with cellular necroptosis. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

Claim (Index 1):
A method for preventing and/or treating disorders associated with cellular necroptosis comprising the administration to a patient in need thereof of an effective amount of a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, wherein:\n R 1  is H, a (C 1 -C 6 )alkyl or a (C 3 -C 6 )cycloalkyl, or R 1  forms together with R 2  or R 4  a heterocycloalkyl; \n R 2  to R 6  are, independently of one another, H or OR 10 ; \n R 10  is H or (C 1 -C 6 )alkyl; \n R 7  to R 9  are, independently of one another, H; halo; or a group selected from (C 1 -C 6 )alkyl, heterocycle, aryl, heteroaryl, \u2014(C 1 -C 6 )alkyl-aryl, and \u2014(C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, \u2014OR 36 , \u2014NR 37 R 38 , \u2014SR 39 , \u2014S(O)R 40 , \u2014SO 2 R 41 , \u2014SO 2 NR 42 R 43 , \u2014OCOR 44 , \u2014NR 45 COR 46 , \u2014NR 47 C(O)OR 48 , \u2014CO 2 R 49 , \u2014CONR 50 R 51 , \u2014OCONR 53 R 54 , \u2014COR 55 , nitro (\u2014NO 2 ), cyano (\u2014CN), oxo (\u2550O), and a group selected from aryl, heterocycle and \u2014(C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several (C 1 -C 6 )-alkyl; and \n R 36  to R 55  are, independently of one another, H, halo, benzoylbenzyl, or a group selected from (C 1 -C 6 )alkyl, aryl, heteroaryl, heterocycle, \u2014(C 1 -C 6 )alkyl-heterocycle, and \u2014(C 1 -C 6 )alkyl-aryl, said group being optionally substituted with one or several groups selected from halo, CF 3  and (C 1 -C 6 )alkyl; or R 37 -R 38 , R 42 -R 43 , R 50 -R 51 , and/or R 53 -R 54  may together respectively form a heterocycloalkyl.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 91.0
- Lexical Diversity: 2.21429
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15768395', '12086792', '15100967', '11998817', '14703004']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.767950974115348
- 35 USC 102 Novelty (BERT): 0.6195511196960146
- Combined Prediction Score: 0.7531109886734146
- Mean Citation Score: 388.673318
- Max Citation Score: 647.97546
- Similarity Product: 492.5993796890188

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test