PATENT CLAIM ANALYSIS

Application Number: 16000968
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "263100"]

Abstract:
Provided herein are Purine Compounds of Formula (I) or pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein R 1 , R 2 , and R 3  are as defined herein, compositions comprising an effective amount of a Purine Compound, and methods for treating or preventing malaria comprising the administration of an effective amount of a Purine Compound.

Claim (Index 20):
The method of  claim 1 , wherein the compound is:\n 9-(2-(1H-imidazol-1-yl)ethyl)-N2-tert-butyl-N8-(3-chlorophenyl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(piperidin-4-yl)-N8-(4-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(piperidin-4-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-(1-(2-aminoethyl)piperidin-4-yl)-N2-tert-butyl-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-(1-(2-aminoethyl)piperidin-4-yl)-N2-tert-butyl-N8-(4-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3,4-dichlorophenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(4-chlorophenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3,4-dichlorophenyl)-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(pyrrolidin-3-yl)-N8-(4-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(pyrrolidin-3-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-(3-aminopropyl)-N2-tert-butyl-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(4-chlorophenyl)-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(2-(pyrrolidin-1-yl)ethyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 4-(2-(tert-butylamino)-9-(piperidin-4-yl)-9H-purin-8-ylamino)benzonitrile, N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(piperidin-4-yl)-N8-(4-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(2-(piperidin-1-yl)ethyl)-9H-purine-2,8-diamine, N8-(3-chlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(2-(pyrrolidin-1-yl)ethyl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(2-(pyrrolidin-3-yl)ethyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(2-(pyrrolidin-2-yl)ethyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3,5-dichlorophenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(piperidin-4-yl)-N8-(4-(trifluoromethoxy)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(2-(piperazin-1-yl)ethyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(piperidin-4-ylmethyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(pyrrolidin-3-ylmethyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(piperidin-4-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-chloro-5-fluorophenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3,5-difluorophenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(piperidin-4-yl)-N8-(3-(trifluoromethoxy)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(5-chloropyridin-3-yl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(piperidin-4-yl)-N8-(2-(trifluoromethyl)pyridin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(3-(dimethylamino)propyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-(difluoromethyl)phenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-cyclopropyl-N8-(3,5-dichlorophenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, 9-(1-(2-aminoethyl)piperidin-4-yl)-N2-tert-butyl-N8-(3,5-dichlorophenyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3,4-dichlorophenyl)-9-(1-methylpiperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3,4-dichlorophenyl)-9-(1-ethylpiperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3,5-dichlorophenyl)-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, 9-(1-(2-aminoethyl)piperidin-4-yl)-N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3,5-dichlorophenyl)-N2-(1-methylcyclopropyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-(1-methylcyclopropyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3,5-dichlorophenyl)-N2-isopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-isopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, 9-(piperidin-4-yl)-N2-(tetrahydro-2H-pyran-4-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-chloro-2-fluorophenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-chloro-5-(trifluoromethoxy)phenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3,5-bis(trifluoromethyl)phenyl)-N2-tert-butyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, 3-(2-(tert-butylamino)-9-(piperidin-4-yl)-9H-purin-8-ylamino)benzonitrile, N8-(3-chloro-5-(trifluoromethyl)phenyl)-9-(piperidin-4-yl)-N2-(tetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclobutyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclopentyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(piperidin-4-yl)-N8-(3-(trifluoromethoxy)phenyl)-9H-purine-2,8-diamine, N8-(3-chloro-5-fluorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-(difluoromethyl)phenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(2-(pyrrolidin-3-yl)ethyl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-(1-methylcyclopentyl)-9-(piperidin-4-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-(1-(2-aminoethyl)pyrrolidin-3-yl)-N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N8-(3,5-dichlorophenyl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-fluorophenyl)-N2-cyclopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-fluorophenyl)-N2-isopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-fluorophenyl)-N2-(1-methylcyclopropyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3,4-dichlorophenyl)-N2-isopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-isopropyl-9-(piperidin-4-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-(1-methylcyclobutyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, (S)\u2014N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclobutyl-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclobutyl-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-isopropyl-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-(1-methylcyclopentyl)-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N8-(3,5-dichlorophenyl)-N2-(1-methylcyclopentyl)-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-(1-methylcyclopropyl)-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N8-(3,5-dichlorophenyl)-N2-(1-methylcyclopropyl)-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(octahydro-1H-isoindol-5-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N8-(4-chloro-3-(trifluoromethyl)phenyl)-N2-isopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(4-chloro-3-(trifluoromethyl)phenyl)-N2-cyclopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-4-(trifluoromethyl)phenyl)-N2-cyclopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-chloro-4-(trifluoromethyl)phenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-4-(trifluoromethyl)phenyl)-N2-cyclobutyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3,5-bis(trifluoromethyl)phenyl)-N2-isopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3,5-bis(trifluoromethyl)phenyl)-N2-cyclopentyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3,5-bis(trifluoromethyl)phenyl)-N2-cyclobutyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(4-chloro-3-(trifluoromethyl)phenyl)-N2-cyclopentyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(4-chloro-3-(trifluoromethyl)phenyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(4-chloro-3-(trifluoromethyl)phenyl)-N2-(1-methylcyclopropyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(4-chloro-3-(trifluoromethyl)phenyl)-N2-(1-methylcyclopentyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-4-(trifluoromethyl)phenyl)-N2-isopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-4-(trifluoromethyl)phenyl)-N2-cyclopentyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-4-(trifluoromethyl)phenyl)-N2-(1-methylcyclopropyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N8-(3-chloro-4-(trifluoromethyl)phenyl)-N2-(1-methylcyclopentyl)-9-(piperidin-4-yl)-9H-purine-2,8-diamine, N2-tert-butyl-9-(octahydrocyclopenta[c]pyrrol-5-yl)-N8-(3-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N8-(3,5-bis(trifluoromethyl)phenyl)-N2-cyclopropyl-9-(piperidin-4-yl)-9H-purine-2,8-diamine, 9-(azetidin-3-yl)-N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9-(pyrrolidin-3-ylmethyl)-9H-purine-2,8-diamine, 3-(2-(tert-butylamino)-9-(pyrrolidin-3-yl)-9H-purin-8-ylamino)-5-chlorobenzonitrile, 9-(2-aminoethyl)-N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 9-(2-amino-2-methylpropyl)-N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclopentyl-9H-purine-2,8-diamine, 9-(2-amino-2-methylpropyl)-N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 3-chloro-5-(2-(isopropylamino)-9-(pyrrolidin-3-yl)-9H-purin-8-ylamino)benzonitrile, N8-(3-chloro-5-fluorophenyl)-N2-isopropyl-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, 9-(2-aminoethyl)-N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclopentyl-9H-purine-2,8-diamine, N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclopentyl-9-(2-(methylamino)ethyl)-9H-purine-2,8-diamine, N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9-(2-(methylamino)ethyl)-9H-purine-2,8-diamine, 9-(2-aminopropyl)-N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclopentyl-9H-purine-2,8-diamine, 9-(2-aminopropyl)-N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, 3-chloro-5-(2-(cyclopentylamino)-9-(pyrrolidin-3-yl)-9H-purin-8-ylamino)benzonitrile, 9-(3-aminobutyl)-N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclopentyl-9H-purine-2,8-diamine, 9-(3-aminobutyl)-N2-tert-butyl-N8-(3-chloro-5-(trifluoromethyl)phenyl)-9H-purine-2,8-diamine, (S)\u2014N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclobutyl-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, or (R)\u2014N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-cyclobutyl-9-(pyrrolidin-3-yl)-9H-purine-2,8-diamine, or a pharmaceutically acceptable salt, tautomer, isotopologue, or stereoisomer thereof.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 94.0
- Lexical Diversity: 1.59524
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15611108', '15611061', '16000969', '15864499', '15091887']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7910097691181038
- 35 USC 102 Novelty (BERT): 0.6173136142040032
- Combined Prediction Score: 0.7736401536266938
- Mean Citation Score: 428.277916
- Max Citation Score: 563.66614
- Similarity Product: 491.0344076099444

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test