PATENT CLAIM ANALYSIS

Application Number: 15975423
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["424", "179100"]

Abstract:
The present disclosure relates to compounds of formula (I): RCG1-L-P  (I) wherein RCG1 represents a reactive chemical group being reactive towards a chemical group present on a polypeptide such as an antibody; P represents H, OH or an activated O; and L represents a specific linker. The disclosure also relates to cryptophycin payloads, as well as to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The disclosure also relates to the process for preparing these conjugates.

Claim (Index 23):
A process for preparing a conjugate of formula (V) as defined in  claim 17  comprising at least the steps of:\n (i) placing in contact and leaving to react: an optionally buffered aqueous solution of an antibody, optionally modified by means of a modifying agent, and a solution of a cryptophycin payload of formula (IV), wherein the chemical group RCG1 of the cryptophycin payload of formula (IV) is reactive towards the chemical group RCG2 present on the polypeptide so as to attach the cryptophycin payload of formula (IV) to the antibody by formation of a covalent bond; and \n (ii) optionally separating the conjugate formed in step (i) from the cryptophycin payload of formula (IV) and from the unreacted antibody and from any aggregates that may have formed.

Metadata:
- Claim Count in Document: 55.0
- Percentile: 93.0
- Lexical Diversity: 1.61667
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14069057', '15581749', '15280563', '14843520', '14818455']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7472551569935767
- 35 USC 102 Novelty (BERT): 0.5170252850575495
- Combined Prediction Score: 0.724232169799974
- Mean Citation Score: 309.744996
- Max Citation Score: 313.26495
- Similarity Product: 220.8031998579651

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test