PATENT CLAIM ANALYSIS

Application Number: 15870014
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["548", "101000"]

Abstract:
The present invention relates to intermediates of Formula I and to methods of synthesizing and purifying calicheamicin derivatives.

Claim (Index 102):
A method for synthesizing a linker intermediate of Formula V wherein R 8  and R 9  are each independently selected from hydrogen and straight and branched-chain C 1 -C 8  alkyl, wherein each said alkyl for R 8  and R 9  is independently optionally substituted by \u2014NH 2 , \u2014NHR 11 , \u2014NR 11 R 13 , \u2014OR 11 , \u2014OH, or \u2014SR 11 , wherein each R 11  and each R 13  are independently selected from straight and branched-chain C 1 -C 5  alkyl; r is an integer selected from 0 and 1; G is oxygen or sulfur; Z 1  is H or straight or branched-chain C 1 -C 5  alkyl; Ar is 1,2-, 1,3-, or 1,4-phenylene optionally substituted with one, two or three groups independently selected from straight or branched-chain C 1 -C 6  alkyl, \u2014OR 14 , \u2014SR 14 , halogen, nitro, \u2014COOR 14 , \u2014C(\u2550O)NHR 14 , \u2014O(CH 2 ) n COOR 14 , \u2014S(CH 2 ) n COOR 14 , \u2014O(CH 2 ) n C(\u2550O)NHR 14 , and \u2014S(CH 2 ) n C(\u2550O)NHR 14 , or Ar is a 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, 1,7-, 1,8-, 2,3-, 2,6-, or 2,7-naphthylidene optionally substituted with one, two, three, or four groups independently selected from straight or branched-chain C 1 -C 6  alkyl, \u2014OR 14 , \u2014SR 14 , halogen, nitro, \u2014COOR 14 , \u2014C(\u2550O)NHR 14 , \u2014O(CH 2 ) n COOR 14 , \u2014S(CH 2 ) n COOR 14 , \u2014O(CH 2 ) n C(\u2550O)NHR 14 , and \u2014S(CH 2 ) n C(\u2550O)NHR 14 ; wherein each R 14  is independently selected from (C 1 -C 5 )alkyl and each R 14  is independently optionally substituted with one or two groups selected from \u2014OH, \u2014(C 1 -C 4 )alkyl, and \u2014S(C 1 -C 4 )alkyl; each n is an integer independently selected from 0, 1, 2, 3, 4, and 5; W is selected from \u2014O\u2014, \u2014S\u2014, \u2014C(\u2550O)NH\u2014, \u2014NHC(\u2550O)\u2014, and \u2014NR 15 \u2014, wherein R 15  is a (C 1 -C 5 )alkyl and R 15  is optionally substituted with one or two groups selected from \u2014OH, \u2014(C 1 -C 4 )alkyl, and \u2014S(C 1 -C 4 )alkyl; Y is a straight or branched-chain (C 1 -C 6 )alkylene group or a straight or branched-chain (C 2 -C 6 )alkylene group; and Z is selected from the group consisting of which method comprises a) treating a compound of Formula I wherein R 12  is selected from straight and branched-chain C 1 -C 8  alkyl, and each R 10  is independently selected from hydrogen, R 12  and \u2014OR 12 ; with a strong acid to form a mixture comprising a compound of Formula IV b) reacting the compound of Formula IV with a compound ZH; thereby synthesizing the linker intermediate of Formula V.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 86.0
- Lexical Diversity: 1.1875
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15030563', '12583237', '14711267', '14286708', '10355125']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7571943664259644
- 35 USC 102 Novelty (BERT): 0.5565890614838068
- Combined Prediction Score: 0.7371338359317486
- Mean Citation Score: 321.8862180000001
- Max Citation Score: 441.5852
- Similarity Product: 362.7412658123493

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test