PATENT CLAIM ANALYSIS

Application Number: 16012635
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["506", "016000"]

Abstract:
Disclosed herein include systems, methods, compositions, and kits for sample identification. A sample indexing composition can comprise, for example, a protein binding reagent associated with a sample indexing oligonucleotide. Different sample indexing compositions can include sample indexing oligonucleotides with different sequences. Sample origin of cells can be identified based on the sequences of the sample indexing oligonucleotides. Sample indexing oligonucleotides can be barcoded using barcoded and lengthened using daisy-chaining primers.

Claim (Index 17):
The method of  claim 1 , wherein each of the one or more cells comprises a plurality of proteins of interest, and wherein:\n step (a) further comprises contacting a plurality of second oligonucleotide-conjugated antibodies with the one or more cells, wherein each of the second plurality of oligonucleotide-conjugated antibodies comprises an antibody conjugated with an antibody specific oligonucleotide comprising a unique identifier for the antibody conjugated therewith and a poly(A) tail, and wherein the antibody is capable of specifically binding to at least one of the plurality of proteins of interest; step (e) further comprises extending the oligonucleotide probes hybridized to the antibody specific oligonucleotides via the hybridization between the poly(A) tails of the antibody specific oligonucleotides and the poly(T) regions of the oligonucleotide probes to produce a second plurality of labeled nucleic acids, wherein each of the second plurality of labeled nucleic acid comprises a unique identifier, or a complementary sequence thereof, and a barcode sequence; and step (f) further comprises obtaining sequence information of the second plurality of labeled nucleic acids or a portion thereof to determine the quantity of one or more of the plurality of proteins of interest in at least one of the one or more cells.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 1.81818
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15937713', '15993468', '15055445', '15667125', '15847752']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5824777556272516
- 35 USC 102 Novelty (BERT): 0.6519378267239596
- Combined Prediction Score: 0.5894237627369224
- Mean Citation Score: 477.22066800000016
- Max Citation Score: 676.4635599999998
- Similarity Product: 582.5782231215188

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test