PATENT CLAIM ANALYSIS

Application Number: 15750205
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "171000"]

Abstract:
Carboxy-substituted (hetero)aryl derivatives, pharmaceutical compositions comprising these compounds, and methods of preparing such compounds and compositions are provided. The compounds or compositions are useful in inhibiting xanthine oxidase and urate anion transporter 1, and also can be used in the treatment or prevention of diseases associated with high blood uric acid level in mammals, especially humans.

Claim (Index 1):
A compound of Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, an ester, a pharmaceutically acceptable salt or a prodrug thereof wherein:\n U is phenyl or 5- to 6-membered heteroaryl; \n each R 1  and R 2  is independently H, D, halogen, OH, NH 2 , NO 2 , CN, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylamino, C 1-6  haloalkylamino, 3- to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl, wherein each of the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylamino, C 1-6  haloalkylamino, 3- to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from OH, oxo (\u2550O), NH 2 , NO 2  or CN; \n T is H, D, F, Cl, Br, NO 2 , CN or CF 3 ; \n X is CR 4  or N; \n R 4  is H, D, halogen, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  alkylamino or C 1-6  haloalkoxy; \n each of Y and Z is independently C, CH or N; \n \u201c \u201d refers to a single bond or a double bond; \n Q is phene, C 4-7  carbocycle, 4- to 7-membered heterocycle or 5- to 6-membered heteroaromatic ring; \n each R 3  is independently H, D, halogen, oxo (\u2550O), OH, NH 2 , NO 2 , CN, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylamino, C 1-6  haloalkylamino, 3- to 8-membered cycloalkyl, 3- to 8-membered heterocyclyl, 5- to 10-membered heteroaryl, phenyl, naphthyl or G, wherein each of the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylamino, C 1-6  haloalkylamino, 3- to 8-membered cycloalkyl, 3- to 8-membered heterocyclyl, or 5- to 10-membered heteroaryl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from OH, oxo (\u2550O), NH 2 , NO 2 , CN or G; \n G is substituted C 1-6  aliphatic hydrocarbon, wherein each of the methylene groups of the C 1-6  aliphatic hydrocarbon is optionally and independently substituted with J; \n J is \u2014NH\u2014, \u2014S\u2014, \u2014O\u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550O)NH\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014NHC(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014SO 2 NH\u2014 or \u2014NHC(\u2550O)NH\u2014; \n m is 0, 1, 2 or 3; and \n n is 0, 1, 2, 3 or 4; \n with the proviso that: \n (1) when T is F, Cl, Br or CF 3 , R 1  is OH; \n (2) when T is H, and Q is not phene; (3) when T is NO 2 , R 1  is not H.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 88.0
- Lexical Diversity: 1.32653
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14889563', '15545429', '15745437', '13124345', '14648664']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7694031576418203
- 35 USC 102 Novelty (BERT): 0.5195403884351425
- Combined Prediction Score: 0.7444168807211525
- Mean Citation Score: 295.887374
- Max Citation Score: 306.7022
- Similarity Product: 251.98253012135032

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test