PATENT CLAIM ANALYSIS

Application Number: 15959809
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
This invention is intended to enhance and improve the resistance of a single- or double-stranded nucleic acid fragment comprising a base sequence of a functional nucleic acid to degradation by nucleolytic enzymes in a simple and cost-effective manner. The single- or double-stranded nucleic acid fragment comprises, ligated to at least one end thereof, hairpin-shaped DNA comprising: (A) a nucleic acid region comprising 2 to 5 arbitrary nucleotides; (B) a nucleic acid region comprising a “gna” or “gnna” base sequence, wherein each “n” represents “g”, “t”, “a”, or “c”, a base analogue, or a modified base; and (C) a nucleic acid region comprising a base sequence complementary to the nucleic acid region (A), sequentially from the 5′ end toward the 3′ end.

Claim (Index 4):
The nucleic acid according to  claim 1 , when the nucleic acid fragment is the double-stranded nucleic acid fragment according to  claim 1  (2), wherein the hairpin-shaped DNA is ligated to the ends according to any of (1) to (4) below:\n (1) the 5\u2032 end and the 3\u2032 end of a nucleic acid fragment comprising the base sequence of an siRNA sense strand; \n (2) the 5\u2032 end and the 3\u2032 end of a nucleic acid fragment comprising the base sequence of an siRNA antisense strand; \n (3) the 3\u2032 end of a nucleic acid fragment comprising the base sequence of an siRNA sense strand and the 3\u2032 end of a nucleic acid fragment comprising the base sequence of an siRNA antisense strand; and \n (4) the 5\u2032 end of a nucleic acid fragment comprising the base sequence of an siRNA sense strand and the 5\u2032 end of a nucleic acid fragment comprising the base sequence of an siRNA antisense strand.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 91.0
- Lexical Diversity: 2.15068
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14355711', '12735222', '10567168', '12996362', '14514112']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7170516402596269
- 35 USC 102 Novelty (BERT): 0.5416771329419635
- Combined Prediction Score: 0.6995141895278605
- Mean Citation Score: 358.255958
- Max Citation Score: 375.12192000000016
- Similarity Product: 295.81044648559583

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test