PATENT CLAIM ANALYSIS

Application Number: 16126594
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-02
Patent Classification: ["424", "093210"]

Abstract:
Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons.

Claim (Index 18):
A method of providing a cell culture enriched for GABAergic neuronal precursors, the method comprising:\n a) providing a culture of primate pluripotent stem (pPS) cells; b) introducing to the cultured pPS cells, factors comprising:\n i) an activator of the sonic hedgehog (shh) pathway, \n ii) a SMAD inhibitor, and iii) a wnt pathway inhibitor; \n c) culturing the pPS cells to produce a cell culture enriched in MGE precursor cells; and d) introducing a Notch pathway inhibitor to the cell culture enriched in MGE precursor cells; wherein steps a) through d) result in a cell culture enriched in GABAergic neuronal precursors.

Metadata:
- Claim Count in Document: 86.0
- Percentile: 97.0
- Lexical Diversity: 1.5625
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14763397', '13201137', '14168835', '14169286', '15159351']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6542094029762219
- 35 USC 102 Novelty (BERT): 0.6908094272829621
- Combined Prediction Score: 0.657869405406896
- Mean Citation Score: 426.22054800000006
- Max Citation Score: 766.4355
- Similarity Product: 669.5829547760189

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test