PATENT CLAIM ANALYSIS

Application Number: 16178257
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "171000"]

Abstract:
Provided herein is a pharmaceutical composition comprising (i) a phosphodiesterase inhibitor or an adenosine receptor antagonist, (ii) a calcium channel blocker, (iii) a histamine H 1 -receptor agonist, a histamine H 2 -receptor agonist, or a histamine H 3 -receptor antagonist, and (iv) a β 2 -adrenoreceptor agonist; wherein at least one of two or more active pharmaceutical compounds is deuterium enriched. Also provided herein is a pharmaceutical composition comprising at least one of two or more deuterated compounds which increase pharmacokinetic half-life (increasing the duration of action) and reduce side effects by allowing for reduction of the dose levels. A method of use thereof pharmaceutical composition for treating, preventing, or ameliorating a cardiovascular disease.

Claim (Index 13):
The pharmaceutical composition of  claim 1 , wherein the \u03b2 2 -adrenergic receptor agonist is albuterol, albuterol hydrochloride, bambuterol, bitolterol, clenbuterol, fenoterol, formoterol, indacaterol, isoprenaline, metaproterenol, olodaterol, pirbuterol, procaterol, ritodrine, salbutamol, terbutaline, vilanterol, albuterol or levalbuterol hydrochloride, or an isotopic variant thereof; or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

Metadata:
- Claim Count in Document: 45.0
- Percentile: 98.0
- Lexical Diversity: 1.78947
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11521926', '13438105', '12075107', '12132147', '11077345']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7435286087548351
- 35 USC 102 Novelty (BERT): 0.4804176731741785
- Combined Prediction Score: 0.7172175151967694
- Mean Citation Score: 217.81704
- Max Citation Score: 222.36911
- Similarity Product: 200.8076160971421

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test