PATENT CLAIM ANALYSIS

Application Number: 16146807
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["435", "006100"]

Abstract:
Provided herein is a method of sequencing hydroxymethyated cell-free DNA. In some embodiments, the method comprises adding an affinity tag to only hydroxymethyated DNA molecules in a sample of cfDNA, enriching for the DNA molecules that are tagged with the affinity tag; and sequencing the enriched DNA molecules.

Claim (Index 18):
The method of  claim 17 , wherein the target loci include one or more of the following gene bodies: ABRACL, ADAMTS4, AGPG2, ALDH1A3, ALG 10B, AMOTL1, APCDD1L-AS1, ARL6IP6, ASP1B, ATP6V0A2, AUNIP, BAGE, C2orf62, C8orf22, CALCB, CC2D1B, CCDC33, CCNL2, CLDN15, COMMD6, CPLX2, CRP, CTRC, DACH1, DAZL, DDX11L1, DHRS3, DUSP26, DUSP28, EPN3, EPPIN-WPDC6, ETAA1, PAM96A, FENDRR, PLJ16779, PLJ31813, GBX1, GLP2R, GMCL1P1, GNPDA2, GPR26, GSTP1, HMOX2, HOXC5, IGSP9B, INSC, INSL4, IRF7, KIP16B, KIP20B, LARS, LDHD, LHX5, LINC00158, LINC00304, LOC100128946, LOC100131234, LOC100132287, LOC100506963, LOC100507250, LOC100507410, LOC255411, LOC729737, MAPP, NPAS4, NRADDP, P2RX2, PAIP1, PAX1, PODXL2, POU4P3, PSMG1, PTPN2, RAG1, RBM14-RBM4, RDH11, RPPL3, RNP122, RNP223, RNP34, SAMD11, SHISA2, SIGLEC1O, SLAMP7, SLC25A46, SLC25A47, SLC9A3R2, SORD, SOX18, SPATA31E1, SSR2, STXBP3, SYT11, SYT2, TCEA3, THAP7-AS1, TMEM168, TMEM65, TMX2, TPM4, TPO, TRAM1, TTC24, UBQLN4, WASH7P, ZNF284, ZNF423, ZNF444, ZNF800, ZNF850, and ZRANB2.

Metadata:
- Claim Count in Document: 54.0
- Percentile: 97.0
- Lexical Diversity: 1.47222
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14983379', '13555037', '13009718', '12958353', '13600043']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.578986322831753
- 35 USC 102 Novelty (BERT): 0.5040713297184017
- Combined Prediction Score: 0.5714948235204179
- Mean Citation Score: 238.7877
- Max Citation Score: 248.1314
- Similarity Product: 164.9707372396827

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test