PATENT CLAIM ANALYSIS

Application Number: 15986059
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["514", "114000"]

Abstract:
β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types.

Claim (Index 36):
A pharmaceutical composition comprising:\n the compound of  claim 34  or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable vehicle.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 93.0
- Lexical Diversity: 2.43103
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15227237', '15693905', '15182851', '15181020', '15594904']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8187126947795176
- 35 USC 102 Novelty (BERT): 0.6556317879426449
- Combined Prediction Score: 0.8024046040958304
- Mean Citation Score: 614.676122
- Max Citation Score: 852.2758
- Similarity Product: 578.2559703597784

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test