PATENT CLAIM ANALYSIS

Application Number: 15779419
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-01
Patent Classification: ["514", "04400A"]

Abstract:
Provided herein are compositions, method and uses for modulating MCT4 activity or for the treatment of cancer. The compositions comprise antisense oligonucleotides (ASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of MCT4. The cancer may be selected from one or more of: prostate cancer; renal cell carcinoma; breast cancer; cervical cancer; liver cancer; bladder cancer; and small cell lung cancer pr. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Claim (Index 19):
An antisense oligonucleotide (ASO), wherein the oligonucleotide has a sequence selected from the following: (SEQ\u2003ID\u2003NO:\u20031) (a) TCCCATGGCCAGGAGGGTTG;   (SEQ\u2003ID\u2003NO:\u20032) (b) GTCCCGGAAGACGCTCAGGT;   (SEQ\u2003ID\u2003NO:\u20033) (c) AAGGACGCAGCCACCATGCC;   (SEQ\u2003ID\u2003NO:\u20034) (d) TTGGCGTAGCTCACCACGAA;   (SEQ\u2003ID\u2003NO:\u20035) (e) AGATGCAGAAGACCACGAGG;   (SEQ\u2003ID\u2003NO:\u20036) (f) CCACTCTGGAATGACACGGT;   (SEQ\u2003ID\u2003NO:\u20037) (g) GTAGGAGAAGCCAGTGATGAC;   (SEQ\u2003ID\u2003NO:\u20038) (h) AGCATGGCCAGCAGGATGGA;   (SEQ\u2003ID\u2003NO:\u20039) (i) GGCTGGAAGTTGAGTGCCAA;   (SEQ\u2003ID\u2003NO:\u200310) (j) CATGCCGTAGGAGATGCCAA;   (SEQ\u2003ID\u2003NO:\u200311) (k) CTCAGGCTGTGGCTCTTTGG;   (SEQ\u2003ID\u2003NO:\u200312) (l) TAGCGGTTCAGCATGATGA;   (SEQ\u2003ID\u2003NO:\u200313) (m) AGCACGGCCCAGCCCCAGCC;   (SEQ\u2003ID\u2003NO:\u200314) (n) GAGCTCCTTGAAGAAGACACT;   (SEQ\u2003ID\u2003NO:\u200315) (o) CAGGATGGAGGAGATCCAGG;   (SEQ\u2003ID\u2003NO:\u200316) (p) AGACCCCCCACAAGCATGAC;   (SEQ\u2003ID\u2003NO:\u200317) (q) GAAGTTGAGTGCCAAACCCAA;   (SEQ\u2003ID\u2003NO:\u200318) (r) CCCGTTGGCCATGGGGCGCC;   (SEQ\u2003ID\u2003NO:\u200319) (s) GCCAGCCCGTTGGCCATGGG;   (SEQ\u2003ID\u2003NO:\u200320) (t) AGGAAGACAGGGCTACCTGC;   (SEQ\u2003ID\u2003NO:\u200321) (u) GCACACAGGAAGACAGGGCT;   (SEQ\u2003ID\u2003NO:\u200322) (v) CAGGGCACACAGGAAGACAG;   (SEQ\u2003ID\u2003NO:\u200323) (w) CAGCAGTTGAGCAGCAGGCC;   (SEQ\u2003ID\u2003NO:\u200346) (x) ATGGCCAGGAGGGTTG;   (SEQ\u2003ID\u2003NO:\u200347) (y) CATGGCCAGGAGGGTT;   (SEQ\u2003ID\u2003NO:\u200348) (z) CCATGGCCAGGAGGGT; and   (SEQ\u2003ID\u2003NO:\u200349) (aa) CCCATGGCCAGGAGGG.

Metadata:
- Claim Count in Document: 42.0
- Percentile: 93.0
- Lexical Diversity: 1.77778
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15211857', '12578471', '14247799', '11470331', '13546799']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8184225014971019
- 35 USC 102 Novelty (BERT): 0.5839949771746412
- Combined Prediction Score: 0.7949797490648559
- Mean Citation Score: 393.812492
- Max Citation Score: 514.1102
- Similarity Product: 407.7895835483312

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test