PATENT CLAIM ANALYSIS

Application Number: 15904143
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "232200"]

Abstract:
The present invention provides compounds of any one of Formulae (I) to (V) (e.g., compounds of any one of Formulae (I-1) to (I-9)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase.

Claim (Index 5):
The compound of  claim 4 , wherein the compound is of Formula (I-a1): or a pharmaceutically acceptable salt thereof, wherein:\n each instance of R Xc  is selected from the group consisting of hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, \u2014OR A1 , \u2014N(R A1 ) 2 , \u2014SR A1 , \u2014CN, \u2014C(\u2550O)R A , \u2014C(\u2550O)OR A1 , \u2014C(\u2550O)N(R A1 ) 2 , \u2014NO 2 , \u2014N 3 , \u2014NR A1 C(\u2550O)R A1 , \u2014NR A1 C(\u2550O)OR A1 , \u2014NR A1 C(\u2550O)N(R A1 ) 2 , \u2014NR A1  S(\u2550O) 2 R A1 , \u2014NR A1  S(\u2550O)R A1 , \u2014OC(\u2550O)R A1 , \u2014OC(\u2550O)OR A1 , \u2014OC(\u2550O)N(R A1 ) 2 , \u2014S(\u2550O)R A1 , \u2014S(\u2550O)N(R A1 ) 2 , \u2014S(\u2550O) 2 R A1 , and \u2014S(\u2550O) 2 N(R A1 ) 2 .

Metadata:
- Claim Count in Document: 47.0
- Percentile: 88.0
- Lexical Diversity: 1.8481
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15847430', '15104132', '15104005', '14436387', '15114895']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8663495492146834
- 35 USC 102 Novelty (BERT): 0.6227746794462417
- Combined Prediction Score: 0.8419920622378393
- Mean Citation Score: 562.0104859999999
- Max Citation Score: 630.98505
- Similarity Product: 522.1559158973872

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test