PATENT CLAIM ANALYSIS

Application Number: 15937446
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["435", "091100"]

Abstract:
A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

Claim (Index 22):
A direct blood draw tube comprising:\n a composition formulated for stabilizing a direct drawn blood sample having cell-free nucleic acids within the blood sample while the blood sample is within the tube including:\n a) 2-bromo-2-nitropropane-1,3-diol; \n b) imidazolidinyl urea (IDU); \n c) one or more protease inhibitors; \n d) one or more metabolic inhibitors; \n e) beta-mercaptoethanol; \n f) water; \n wherein the composition includes some formaldehyde but less than 2000 parts per million of formaldehyde; wherein an amount of the composition is in an amount so that any consequential dilution of the blood sample is substantially avoided, and cell-free nucleic acids in the sample are not materially diluted; wherein at least about 7 days can elapse between a time of blood draw and a time of any testing or screening of a drawn blood sample, and or isolation of the cell-free nucleic acids contained.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.6
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15601682', '15894077', '14071969', '12704030', '13648415']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6052357401246763
- 35 USC 102 Novelty (BERT): 0.56751700205718
- Combined Prediction Score: 0.6014638663179266
- Mean Citation Score: 384.25828999999993
- Max Citation Score: 451.23248
- Similarity Product: 394.5734501700592

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test