PATENT CLAIM ANALYSIS

Application Number: 15886495
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["424", "178100"]

Abstract:
The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.

Claim (Index 6):
The process of  claim 2 , further comprising holding the second mixture between steps (a)-(b) to release the unstably bound linkers from the cell-binding agent.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 88.0
- Lexical Diversity: 2.4902
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15215857', '14313868', '13434451', '14430701', '15527525']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7228490290927293
- 35 USC 102 Novelty (BERT): 0.5390263343888921
- Combined Prediction Score: 0.7044667596223456
- Mean Citation Score: 357.17169
- Max Citation Score: 371.39172
- Similarity Product: 305.4152299461365

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test