PATENT CLAIM ANALYSIS

Application Number: 15746597
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "210180"]

Abstract:
The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβ R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Claim (Index 3):
A compound according to  claim 2  of formula III wherein:\n R 2  is hydrogen or NHCOR 7 ; \n R 3  is hydrogen, halogen, \u2014CONR 8 R 9  or \u2014OR 10 ; \n R 4  is hydrogen, optionally substituted (C 1 -C 6 )alkyl, \u2014CH 2 NR 11 R 12  or \u2014CONR 11 R 12 ; \n R 5  is hydrogen, \u2014CONHR 13 , \u2014CH 2 NHR 14 R 15 , \u2014CH 2 NH(CH 2 ) m  optionally substituted heterocyclyl or \u2014NHR 14 R 15 ; \n R x  is hydrogen, halogen, optionally substituted (C 1 -C 6 )alkyl or \u2014NHCO(C 1 -C 6 )alkyl; \n R 6  is hydrogen, halogen, optionally substituted (C 1 -C 6 )alkyl, optionally substituted (C 1 -C 6 )alkoxy, \u2014CHF 2 , CF 3 , optionally substituted (C 3 -C 8 )cycloalkyl, \u2014NH 2  or NHSO 2 (C 1 -C 6 )alkyl; \n R 7  is optionally substituted (C 1 -C 6 )alkyl, optionally substituted (C 1 -C 6 )alkoxy, amino(C 1 -C 6 )alkyl or hydroxy(C 1 -C 6 )alkyl; \n R 8  is hydrogen, optionally substituted (C 1 -C 6 )alkoxy or optionally substituted (C 1 -C 6 )alkyl; \n R 9  is hydrogen or optionally substituted heterocyclyl; \n R 10  is optionally substituted (C 1 -C 6 )alkyl; \n R 11  is hydrogen, amino(C 1 -C 6 )alkyl or hydroxy(C 1 -C 6 )alkyl; \n R 12  is hydrogen, amino(C 1 -C 6 )alkyl or hydroxy(C 1 -C 6 )alkyl; or \n R 11  and R 12  are taken together with the nitrogen to which they are attached to form a heterocyclic group; \n R 13  is hydrogen or optionally substituted (C 1 -C 6 )alkyl; \n R 14  is hydrogen or optionally substituted (C 1 -C 6 )alkyl \n R 15  is hydrogen, optionally substituted (C 1 -C 6 )alkyl; or \n R 14  and R 15  are taken together with the nitrogen to which they are attached to form a heterocyclic group; \n n is 1, 2, 3, 4, or 5; \n and/or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

Metadata:
- Claim Count in Document: 36.0
- Percentile: 86.0
- Lexical Diversity: 1.41935
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15747843', '14977709', '13266921', '12085880', '15027585']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7878355254236393
- 35 USC 102 Novelty (BERT): 0.5534709244005923
- Combined Prediction Score: 0.7643990653213346
- Mean Citation Score: 368.039356
- Max Citation Score: 403.93115
- Similarity Product: 323.79490924987203

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test