PATENT CLAIM ANALYSIS

Application Number: 16067830
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-05
Patent Classification: ["514", "231500"]

Abstract:
The present invention relates to 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.

Claim (Index 1):
A compound of general formula (I) in which: R 1  represents a group selected from: wherein * indicates the point of attachment of said group with the rest of the molecule; R 2  represents hydrogen, halogen, \u2014NR 7 R 8 , CN, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, 3- to 10-membered heterocycloalkoxy, C 2 -C 6 -alkenyl, C 3 -C 6 -cycloalkyl, C 4 -C 6 -cycloalkenyl, 3- to 10-membered heterocycloalkyl, 4- to 10-membered heterocycloalkenyl, phenyl, heteroaryl, \u2014(CO)OR 7 ,\n \u2014(CO)NR 7 R 8 , \u2014(SO 2 )R 9 , \u2014(SO)R 9 , \u2014SR 9 , \u2014(SO 2 )NR 7 R 8 , \u2014NR 7 (SO 2 )R 9 , \u2014((SO)\u2550NR 11 )R 10 , \u2014N\u2550(SO)R 9 R 10 , \n \u2014SiR 10 R 11 R 12 , \u2014(PO)(OR 7 ) 2 , \u2014(PO)(OR 7 )R 10  or \u2014(PO)(R 10 ) 2 , \n wherein each C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, 3- to 10-membered heterocycloalkoxy, C 2 -C 6 -alkenyl, C 3 -C 6 -cycloalkyl, 3- to 10-membered heterocycloalkyl, phenyl or heteroaryl is optionally substituted, one or more times, independently from each other, with halogen, OH, \u2014CN, \u2014NR 7 R 8 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 4 -hydroxyalkyl, phenyl-C 1 -C 4 -alkyl, (C 1 -C 4 -alkoxy)-(C 1 -C 4 -alkyl)-, C 1 -C 6 -alkoxy, C 3 -C 6 -cycloalkyl, 3- to 6-membered heterocycloalkyl, phenyl, \u2014(CO)OR 7 , \u2014(CO)NR 7 R 8 , \u2014NR 7 (CO)R 10 , \u2014NR 8 (CO)OR 7 , \u2014NR 8 (CO) NR 7 R 8 , \u2014(SO 2 )R 9 , \u2014(SO)R 9 , \u2014SR 9 , \u2014(SO 2 )NR 7 R 8 , \u2014NR 7 (SO 2 )R 9 , \u2014((SO)\u2550NR 11 )R 10 , \u2014N\u2550(SO)R 9 R 10 , \u2014(PO)(OR 7 ) 2 , \u2014(PO)(OR 7 )R 10 , \u2014(PO)(R 10 ) 2 , with a heteroaryl group which is optionally substituted one or more times with C 1 -C 4 -alkyl, or \n wherein two substituents of said phenyl group attached to two adjacent phenyl ring atoms are linked to one another to jointly form a methylenedioxy, ethylenedioxy, ethyleneoxy or trimethyleneoxy group; \n wherein each 4- to 10-membered heterocycloalkenyl is optionally substituted, one or more times, indepently from each other, with C 1 -C 4 -alkyl; \n R 3 , R 4  represent, independently from each other, hydrogen or methyl; R 5  represents C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl or C 1 -C 6 -alkoxy; R 7 , R 8  represent, independently from each other, hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, phenyl or phenyl-CH 2 \u2014, which phenyl is optionally substituted, one or more times, with halogen; or R 7  and R 8  together represent a 4-, 5-, 6- or 7-membered cyclic amine group, which is optionally substituted, one or more times, independently from each other, with a substituent selected from C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, said 4-, 5-, 6- or 7-membered cyclic amine group optionally containing one further heteroatom selected from the group consisting of O, N and S; R 9  represents C 1 -C 4 -alkyl or phenyl, wherein each C 1 -C 4 -alkyl or phenyl is optionally substituted, one or more times, independently from each other, with R 13 ; R 10  represents C 1 -C 4 -alkyl; or R 9  and R 10  together, in case of \u2014N\u2550(SO)R 9 R 10  group, represent a 5- to 8-membered heterocycloalkyl group; R 11  represents hydrogen, C 1 -C 4 -alkyl, \u2014(CO)OR 7 , \u2014(CO)NR 7 R 8  or CN; R 12  represents hydrogen or C 1 -C 4 -alkyl; R 13  represents halogen, OH, \u2014NR 7 R 8 , CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 2 -C 6 -alkenyl, C 3 -C 6 -cycloalkyl, \u2014(CO)OR 7  or \u2014(CO)NR 7 R 8 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 95.0
- Lexical Diversity: 1.72
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15159548', '15501079', '11424751', '11529992', '13325751']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.792537831818418
- 35 USC 102 Novelty (BERT): 0.605032853043387
- Combined Prediction Score: 0.7737873339409149
- Mean Citation Score: 367.023574
- Max Citation Score: 514.3403
- Similarity Product: 489.50304483149046

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test