PATENT CLAIM ANALYSIS

Application Number: 16011055
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-11
Patent Classification: ["536", "029200"]

Abstract:
Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.

Claim (Index 14):
A compound of Formula II of  claim 1  represented by Formula VI: or an acceptable salt, thereof; wherein:\n R 1  is H, (C 1 -C 8 )alkyl, (C 4 -C 8 )carbocyclylalkyl, (C 1 -C 8 )substituted alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )substituted alkenyl, (C 2 -C 8 )alkynyl, (C 2 -C 8 )substituted alkynyl, or aryl(C 1 -C 8 )alkyl; \n each R 2a  or R 2b  is independently H, F or OR 4 ; \n each R 3  is independently (C 1 -C 8 ) alkyl, (C 1 -C 8 ) substituted alkyl, C 6 -C 20  aryl, C 6 -C 20  substituted aryl, C 2 -C 20  heterocyclyl, C 2 -C 20  substituted heterocyclyl, C 7 -C 20  arylalkyl, C 7 -C 20  substituted arylalkyl, (C 1 -C 8 ) alkoxy, or (C 1 -C 8 ) substituted alkoxy; \n each R 4  or R 7  is independently H, optionally substituted allyl, \u2014C(R 5 ) 2 R 6 , Si(R 3 ) 3 , C(O)R 5 , C(O)OR 5 , \u2014(C(R 5 ) 2 ) m \u2014R 15  or \n or any two of R 4  or R 7  when taken together are \u2014C(R 19 ) 2 \u2014, \u2014C(O)\u2014 or \u2014Si(R 3 ) 2 (X 2 ) m Si(R 3 ) 2 \u2014; each R 15  is independently \u2014O\u2014C(R 5 ) 2 R 6 , \u2014Si(R 3 ) 3 , C(O)OR 5 , \u2014OC(O)R 5  or each R 5 , R 18  or R 19  is independently H, (C 1 -C 8 ) alkyl, (C 1 -C 8 ) substituted alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 ) substituted alkenyl, (C 2 -C 8 ) alkynyl, (C 2 -C 8 ) substituted alkynyl, C 6 -C 20  aryl, C 6 -C 20  substituted aryl, C 2 -C 20  heterocyclyl, C 2 -C 20  substituted heterocyclyl, C 7 -C 20  arylalkyl, or C 7 -C 20  substituted arylalkyl; each R 6  is independently C 6 -C 20  aryl, C 6 -C 20  substituted aryl, or optionally substituted heteroaryl; each R a  is independently H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl(C 1 -C 8 )alkyl, (C 4 -C 8 )carbocyclylalkyl, \u2014C(\u2550O)R 11 , \u2014C(\u2550O)OR 11 , \u2014C(\u2550O)NR 11 R 12 , \u2014C(\u2550O)SR 11 , \u2014S(O)R 11 , \u2014S(O) 2 R 11 , \u2014S(O)(OR 11 ), \u2014S(O) 2 (OR 11 ), or \u2014SO 2 NR 11 R 12 ; X 1  is C\u2014R 10  or N; each X 2  is O or CH 2 ; each m is 1 or 2; each n is independently 0, 1 or 2; each R 8  is halogen, NR 11 R 12 , N(R 11 )OR 11 , NR 11 NR 11 R 12 , N 3 , NO, NO 2 , CHO, CH(\u2550NR 11 ), \u2014CH\u2550NHNR 11 , \u2014CH\u2550N(OR 11 ), \u2014CH(OR 11 ) 2 , \u2014C(\u2550O)NR 11 R 12 , \u2014C(\u2550S)NR 11 R 12 , \u2014C(\u2550O)OR 11 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 4 -C 8 )carbocyclylalkyl, optionally substituted aryl, optionally substituted heteroaryl, \u2014C(\u2550O)(C 1 -C 8 )alkyl, \u2014S(O) n (C 1 -C 8 )alkyl, aryl(C 1 -C 8 )alkyl, CN, OR 11  or SR 11 ; each R 9  or R 10  is independently H, halogen, NR 11 R 12 , N(R 11 )OR 11 , N(R 11 )N(R 11 )(R 12 ), N 3 , NO, NO 2 , CHO, CN, \u2014CH(\u2550NR 11 ), \u2014CH\u2550NNH(R 11 ), \u2014CH\u2550N(OR 11 ), \u2014CH(OR 11 ) 2 , \u2014C(\u2550O)NR 11 R 12 , \u2014C(\u2550S)NR 11 R 12 , \u2014C(\u2550O)OR 11 , R 11 , OR 11  or SR 11 ; each R 11  or R 12  is independently H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 8 )carbocyclyl, (C 4 -C 8 )carbocyclylalkyl, optionally substituted aryl, optionally substituted heteroaryl, \u2014C(\u2550O)(C 1 -C 8 )alkyl, \u2014S(O) n (C 1 -C 8 )alkyl, aryl(C 1 -C 5 )alkyl or Si(R 3 ) 3 ; or R 11  and R 12  taken together with a nitrogen to which they are both attached form a 3 to 7 membered heterocyclic ring wherein any one carbon atom of said heterocyclic ring can optionally be replaced with \u2014O\u2014, \u2014S(O) n \u2014 or \u2014NR a \u2014; or R 11  and R 12  taken together are \u2014Si(R 3 ) 2 (X 2 ) m Si(R 3 ) 2 \u2014; R 17  is OH, OR 18 , \u2014OC(O)OR 18  or \u2014OC(O)R 18 ; wherein each (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl or aryl(C 1 -C 8 )alkyl of each R 1 , R 3 , R 4 , R 5 , R 6 , R 18 , R 19 , R 11  or R 12  is, independently, optionally substituted with one or more halo, hydroxy, CN, N 3 , N(R a ) 2  or OR a ; and wherein one or more of the non-terminal carbon atoms of each said (C 1 -C 8 )alkyl is optionally replaced with \u2014O\u2014, \u2014S(O) n \u2014 or \u2014NR a \u2014; provided that when R 17  is OH or OCH 3 , R 1  is H or CH 3  and each R 2a  and R 2b  is OR 4 , then each R 7  and each R 4  is not H; and provided that the compound of Formula VI is not a compound of Formula VII wherein R 17  is OH and\n (a) X 1  is CH, R 1  is CH 3 , R 8  is NH 2  and R 9  is NH 2  or H; or \n (b) X 1  is CH, R 1  is CH 3 , R 8  is OH and R 9  is NH 2 ; or \n (c) X 1  is CH, each R 1  and R 9  is H and R 8  is NH 2 ; or \n (d) X 1  is N, R 1  is CH 3 , R 8  is NH 2 , and R 9  is H, NH 2  or SCH 3 ; \n (e) X 1  is N, R 1  is CH 3 , R 8  is SCH 3  or NHCH 3 , and R 9  is SCH 3 ; or \n (f) X 1  is N, R 1  is CH 3 , R 8  is OCH 3 , and R 9  is SCH 3 , SO 2 CH 3  or NH 2 ; \n or wherein R 17  is OCH 3 , X 1  is CH, each R 1  and R 9  is H and R 8  is NH 2 .

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 1.57143
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12885917', '13050820', '12702957', '13117060', '12428234']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6504326722604721
- 35 USC 102 Novelty (BERT): 0.5294016327688538
- Combined Prediction Score: 0.6383295683113103
- Mean Citation Score: 346.84789
- Max Citation Score: 353.39343
- Similarity Product: 313.07082563888315

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test