PATENT CLAIM ANALYSIS

Application Number: 16125492
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["435", "005000"]

Abstract:
This application pertains to methods of isolating virus particles and producing virus vaccine composition comprising subject a biological sample to an anion exchange chromatography and a hydroxyapatite chromatography. The application also pertains to rabies virus vaccine compositions and methods of assessing suitability of a virus vaccine composition or releasing a commercial batch of virus vaccine composition for clinical use.

Claim (Index 21):
The method of  claim 1 , wherein the AE chromatography is Capto-DEAE chromatography, comprising:\n i) an AE pre-equilibration step, comprising pre-equilibrating an anion exchange column with an AE pre-equilibrating buffer, ii) an AE loading step, comprising loading the biological sample to the AE column, iii) an AE equilibrating step, comprising equilibrating the anion exchange column with an AE equilibrating buffer, iv) an AE pre-elution step, comprising pre-eluting the anion exchange column with an AE pre-eluting buffer, and v) an AE elution step, comprising eluting the AE column with an AE elution buffer;\n wherein a post-AE chromatography sample is collected from the AE elution step; \n wherein the HA chromatography is CHT chromatography, comprising: \n i) an HA pre-equilibration step, comprising pre-equilibrating an HA column with an HA pre-equilibrating buffer, ii) an HA loading step, comprising loading the post-AE chromatography sample to the HA column, iii) an HA equilibrating step, comprising equilibrating the HA column with an HA equilibrating buffer, iv) an HA pre-elution step, comprising pre-eluting the HA column with an HA pre-eluting buffer, and iv) an HA elution step, comprising eluting the HA column with an HA elution buffer;\n and wherein the each of the AE pre-equilibrating buffer, the AE equilibrating buffer, the AE pre-eluting buffer, the AE elution buffer, the HA pre-equilibrating buffer, the HA equilibrating buffer, the HA pre-eluting buffer and the HA elution buffer is a phosphate buffer, and wherein the phosphate buffer has pH of about 7.0 to about 9.5.

Metadata:
- Claim Count in Document: 77.0
- Percentile: 97.0
- Lexical Diversity: 1.64865
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11922591', '14596978', '12847956', '12851082', '14365027']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5845560164752385
- 35 USC 102 Novelty (BERT): 0.515052172945473
- Combined Prediction Score: 0.5776056321222619
- Mean Citation Score: 291.301386
- Max Citation Score: 300.03723
- Similarity Product: 225.4770515446651

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test