PATENT CLAIM ANALYSIS

Application Number: 16057241
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["355", "067000"]

Abstract:
The inventive subject matter provides methods for reproducibly fabricating hydrogel-based organ and tumor models inside multi-well plates. A hydrogel precursor, which can include cells, is instilled into a well. A pillar is inserted into the well to contact the hydrogel precursor with a surface that can be shaped or textured to provide a desired surface configuration or contour, for example that of a desired organoid or tumor feature. The hydrogel precursor is polymerized and the pillar removed. A second hydrogel precursor, which can contain a different cell type, is then instilled into the well and a second pillar, which can have a different configuration or texture, inserted. Subsequent polymerization generates a second hydrogel portion within the well. Polymerization can be carried out by photopolymerization. Different wells can be aligned with different, individually controlled light sources or a single, collimated light source.

Claim (Index 16):
The method of  claim 15 , wherein at least one of the plurality of third cells and the plurality of fourth cells are selected from the group consisting of cardiomyocytes, cardiac fibroblasts, endothelial cells, vascular smooth muscle cells, parietal cells, podocytes, mesangial cells, keratinocytes, fibroblasts, melanocytes, hepatocytes, fibroblasts, endothelial cells, neurons, glial cells, and Kupffer cells, and a stem cell.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 96.0
- Lexical Diversity: 1.95062
- Patent Class: 355.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15645979', '14575084', '14166744', '14872920', '14247951']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7265622418150842
- 35 USC 102 Novelty (BERT): 0.5051397787991216
- Combined Prediction Score: 0.704419995513488
- Mean Citation Score: 196.003722
- Max Citation Score: 311.73364
- Similarity Product: 211.61125683832643

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test