PATENT CLAIM ANALYSIS

Application Number: 16021551
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "210210"]

Abstract:
A compound of formula (I): wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR 1  or NR 2 R 3 , and R 1  ,R 2 , R 3  and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.

Claim (Index 1):
A process for preparing a compound of formula (Ia) comprising:\n [A] reacting substituted hydroxylamine (V) with an acid (VI) in presence of a coupling agent selected from the group consisting of 1-(3-dimethylamino-propyl)-3-ethylcarbodiimide hydrochloride (EDCI), N-hydroxybenzotriazole-N,N\u2032-dicyclohexylcarbodiimide (HOBT-D CC) and (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBop) to provide an intermediate of formula (VII); [B] removing the benzyl protecting group of the intermediate (VII) with a source of hydrogen in presence of Pd catalyst to provide debenzylated product (VIII); and [C] contacting compound (VIII) with a sulfating agent in the presence of solvent to obtain compound of formula (Ia) wherein: M is hydrogen; and R 1  is a radical selected from the group consisting of: (1) C 1-6  straight or branched chain alkyl which is optionally substituted; (2) C 3-7  cycloalkyl which is optionally substituted; (3) C 4-7  saturated heterocycles containing at least one heteroatom selected from O, N and S wherein the said heterocycle is optionally substituted, the ring S is optionally oxidized to S(O) or S(O) 2  and the free ring N atom may optionally take a substituent; (4) Heterocyclyl (C 1-6 ) alkyl wherein the said heterocycle has the same definition as defined in (3), and the said heterocycle is optionally substituted; (5) C 5-7  membered saturated heterocycles optionally fused with a C 3-7  membered cycloalkyl group to form a bicyclic ring system where the bicyclic ring system so formed is fused either through two adjacent carbon atoms or through a N atom shared by both the rings and the other end of the cycloalkyl chain is attached to the adjacent carbon atom of the molecule, each ring of the said bicyclic ring system independently optionally substituted; (6) C 5-7  membered saturated heterocycles optionally fused with another C 5-7  saturated heterocycle to form a bicyclic ring system where the bicyclic ring system so formed is fused either through two adjacent carbon atoms or through a N atom shared by both the rings, each ring of the said bi-cyclic ring system independently optionally substituted; (7) C 3-7  cycloalkyl which is optionally fused with a C 5-7  membered saturated heterocycle containing at least one heteroatom selected from O, N and S, the said bicyclic ring optionally substituted; (8) Bridged bicyclic ring system having optionally one or two heteroatoms selected from O, N and S, the bicyclic ring system optionally substituted either at the carbon atom or at the free N atom present in the ring; (9) C 5-7  membered saturated heterocycles optionally fused with C 5-7  membered heteroaryl ring where the bicyclic ring system so formed is fused either through two adjacent carbon atoms or through N atom shared by both the rings; (10) C5-7 membered saturated heterocycles optionally fused to a C 3-6  membered ring system through a common carbon atom to form a spiro system optionally containing one heteroatom selected from O, N and S that is present in the spiro ring where the ring S is optionally oxidized to S(O) or S(O)2 and the free N atom present in either ring may optionally take a substituent; and (11) C 5-7  membered heteroaryl (C 1-6 ) alkyl which is optionally substituted.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 94.0
- Lexical Diversity: 1.41304
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15171237', '13690398', '13917932', '14300493', '12812763']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8307325847584138
- 35 USC 102 Novelty (BERT): 0.5885396644966981
- Combined Prediction Score: 0.8065132927322423
- Mean Citation Score: 499.65012800000005
- Max Citation Score: 568.8289
- Similarity Product: 411.4121651762843

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test