PATENT CLAIM ANALYSIS

Application Number: 15944625
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["506", "013000"]

Abstract:
Protein arrays and their use to assay, in a parallel fashion, the protein products of highly homologous or related DNA coding sequences and described. By highly homologous or related it is meant those DNA coding sequences which share a common sequence and which differ only by one or more naturally occurring mutations such as single nucleotide polymorphisms, deletions or insertions, or those sequences which are considered to be haplotypes. Such highly homologous or related DNA coding sequences are generally naturally occurring variants of the same gene. Arrays according to the invention have two or more individual proteins deposited in a spatially defined pattern on a surface in a form whereby a property such as an activity or function of the proteins can be investigated or assayed in parallel by interrogation of the array.

Claim (Index 20):
A method of screening a set of protein moieties that differ in their amino acid sequences at one or more positions and are encoded by one or more naturally-occurring single nucleotide polymorphisms of a DNA sequence of interest for molecules that interact with one or more of the protein moieties comprising the steps of:\n a) bringing one or more test molecules into contact with a protein array which carries the set of protein moieties; and b) detecting an interaction between one or more test molecules and one or more protein moieties on the array; wherein protein moieties of the set of protein moieties are encoded by one or more naturally occurring single nucleotide polymorphisms of a DNA sequence of interest and differ in their amino acid sequences at one or more positions; wherein the protein array comprises a surface on which the protein moieties of the set of protein moieties are deposited at spatially defined locations, the protein moieties being immobilized on the surface by attachment to the surface through a common marker moiety appended to each of the protein moieties of the set of protein moieties such that the protein moieties have their naturally occurring function and/or activity; and wherein the surface has a surface coating that is capable of resisting non-specific protein absorption.

Metadata:
- Claim Count in Document: 43.0
- Percentile: 91.0
- Lexical Diversity: 1.71951
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11401482', '15783770', '14975085', '10257573', '11813646']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5704637558897758
- 35 USC 102 Novelty (BERT): 0.5016376603458168
- Combined Prediction Score: 0.56358114633538
- Mean Citation Score: 240.77558
- Max Citation Score: 248.6571
- Similarity Product: 172.64251976248028

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test