PATENT CLAIM ANALYSIS

Application Number: 16149522
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-01
Patent Classification: ["514", "210180"]

Abstract:
The problem to be solved by the present invention is to provide an anticancer agent for treating tumors resistant to other antitumor agents that inhibit FGFR, and a method for treating such tumors. The present invention provides an antitumor agent for administration to a tumor patient resistant to an FGFR inhibitor, the antitumor agent comprising a 3,5-disubstituted benzene alkynyl compound represented by Formula (I) below or a salt thereof. The present invention also provides a therapeutic method using the anticancer agent.

Claim (Index 17):
A 3,5-disubstituted benzene alkynyl compound or a salt thereof for treatment of a tumor patient resistant to an FGFR inhibitor, the 3,5-disubstituted benzene alkynyl compound being represented by Formula (I): wherein R 1  is the same or different, and each represents C 1 -C 6  alkyl; X 1  and X 2  independently represent N or CH; Y is a group represented by Formula (A): wherein the divalent moiety represented by is a nitrogen-containing C 3 -C 10  heterocycloalkylene group, a group represented by Formula (B): wherein the divalent moiety represented by is a C 3 -C 10  cycloalkylene group, or a group represented by Formula (C): wherein the divalent moiety represented by is a C 6 -C 12  arylene group; R 2  is hydrogen, C 2 -C 6  alkynyl, \u2014C(\u2550O)OR x , \u2014C(\u2550O)N(R x )(R y ), hydroxy-C 1 -C 6  alkyl, di(C 1 -C 6  alkyl)amino-C 1 -C 6  alkyl, or C 2 -C 9  heteroaryl optionally having R 3 ; and R 3  is C 1 -C 6  alkyl or di(C 1 -C 6  alkyl)amino-C 1 -C 6  alkyl; Z is \u2014C(R 4 )\u2550C(R 5 )(R 6 ) or \u2014C\u2261C\u2014R 7 ; R 4 , R 5 , and R 6  are the same or different, and each represents hydrogen, halogen, C 1 -C 6  alkyl optionally having R 8 , or a group represented by Formula (D): wherein the monovalent moiety represented by is a nitrogen-containing C 3 -C 10  heterocycloalkyl group, R 7  is hydrogen, C 1 -C 6  alkyl, or hydroxy-C 1 -C 6  alkyl; R 8  is \u2014OR x  or \u2014N(R x )(R y ); R 9  is C 1 -C 6  alkyl, halogen, or \u2014OR x ; R x  and R y  are the same or different, and each represents hydrogen, C 1 -C 6  alkyl, C 3 -C 10  cycloalkyl, di(C 1 -C 6  alkyl)amino-C 1 -C 6  alkyl, or C 1 -C 6  alkoxy-C 1 -C 6  alkyl; l is an integer of 0 to 3; m is an integer of 1 to 3; and n is an integer of 0 to 2.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 97.0
- Lexical Diversity: 1.69231
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14905047', '13859569', '14344935', '15575448', '13617035']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7587320260423078
- 35 USC 102 Novelty (BERT): 0.6135973157495088
- Combined Prediction Score: 0.7442185550130279
- Mean Citation Score: 361.98346
- Max Citation Score: 551.84607
- Similarity Product: 478.99102476522086

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test