PATENT CLAIM ANALYSIS

Application Number: 15914800
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "006000"]

Abstract:
The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.

Claim (Index 15):
A nucleic acid probe comprising a fragment of MECP2 sequence or the complementary thereof, wherein the MECP2 sequence has the sequence of SEQ ID NO: 1, and comprises a mutation selected from the group consisting of: (1) a deletion of 11 consecutive base pairs in nucleotides 38 to 54 of SEQ ID NO: 1, said deletion causing a truncation of the MECP2E1 protein of SEQ ID NO: 4 after amino acid 36; (2) a deletion consisting of nucleotides 1-69 of exon 1 of SEQ ID NO: 1; (3) a deletion of a T, G or TG between nucleotide positions 69-71 of SEQ ID NO: 1; (4) an insertion of one or more copies of the trinucleotide sequence GCC between nucleotides 11 and 29 of SEQ ID No: 1; (5) a deletion of one or more copies of the trinucleotide sequence GCC between nucleotides 11 and 29 of SEQ ID No: 1; (6) an insertion of the nucleotide sequence GGA between nucleotides 38 and 54 of SEQ ID No: 1; (7) a deletion of the nucleotide sequence GC at nucleotides \u221238 and \u221239 upstream of a position corresponding to nucleotide 1 of SEQ ID NO: 1; and (8) a deletion of the nucleotide sequence AG at nucleotides \u221219 and \u221220 upstream of a position corresponding to nucleotide 1 of SEQ ID NO:1; and\n wherein the nucleic acid probe specifically binds under high stringency conditions to the MECP2 sequence, and wherein the nucleic acid probe is detectably labeled.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 90.0
- Lexical Diversity: 1.22581
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12313251', '15914770', '11352153', '14100889', '12657559']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7122354481223095
- 35 USC 102 Novelty (BERT): 0.5981073786452945
- Combined Prediction Score: 0.7008226411746081
- Mean Citation Score: 543.3589479999998
- Max Citation Score: 560.99493
- Similarity Product: 473.93851222912247

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test