PATENT CLAIM ANALYSIS

Application Number: 16063297
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "619000"]

Abstract:
The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R 1  is —OH, R 2  is —NO 2  and R 3  is H, R 4  and R 5  are H, one of R 6  and R 7  is selected from H, —CONH 2 , and —CONR 9 2 , and the other one is selected from —CONR 9 2  and —CONR 11 R 9 , wherein R 9  and R 11  are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.

Claim (Index 12):
A compound selected from the following formulae:\n N2,N2,N3,N3-tetraethyl-6,7-dihydroxy-5-nitro-naphthalene-2,3-dicarboxamide (A1), (3-[[3-(diethylcarbamoyl)-6,7-dihydroxy-5-nitro-naphthalene-2-carbonyl]-ethyl-amino]propyl acetate) (A2), N2-(6-aminohexyl)-N2,N3,N3-triethyl-6,7-dihydroxy-5-nitro-naphthalene-2,3-dicarboxamide (A4), N2,N3,N3-triethyl-6,7-dihydroxy-N2-[4-[methyl(pentanoyl)amino]butyl]-5-nitro-naphthalene-2,3-dicarboxamide (A5), tert-butyl N-[6-[[3-(diethylcarbamoyl)-6,7-dihydroxy-5-nitro-naphthalene-2-carbonyl]-ethyl-amino]hexyl]carbamate (A6), 4-[4-[[3-(diethylcarbamoyl)-6,7-dihydroxy-5-nitro-naphthalene-2-carbonyl]-ethyl-amino]butyl-methyl-amino]-4-oxo-butanoic acid (A8), N2-[4-[4-aminobutanoyl(methyl)amino]butyl]-N2,N3,N3-triethyl-6,7-dihydroxy-5-nitro-naphthalene-2,3-dicarboxamide (A9), tert-butyl N-[4-[4-[[3-(diethylcarbamoyl)-6,7-dihydroxy-5-nitro-naphthalene-2-carbonyl]-ethyl-amino]butyl-methyl-amino]-4-oxo-butyl]carbamate (A10), N2,N3,N3-triethyl-6,7-dihydroxy-N2-[4-[[6-(2-methoxyphenyl)-6-oxo-hexanoyl]-methyl-amino]butyl]-5-nitro-naphthalene-2,3-dicarboxamide (A11) and tert-butyl N-[1-cyclohexyl-2-[4-[[3-(diethylcarbamoyl)-6,7-dihydroxy-5-nitro-naphthalene-2-carbonyl]-ethyl-amino]butyl-methyl-amino]-2-oxo-ethyl]carbamate (A13).

Metadata:
- Claim Count in Document: 7.0
- Percentile: 94.0
- Lexical Diversity: 1.98649
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['11202611', '15437618', '11948239', '13002475', '10621276']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7549151472469885
- 35 USC 102 Novelty (BERT): 0.4966178990493646
- Combined Prediction Score: 0.7290854224272261
- Mean Citation Score: 212.110892
- Max Citation Score: 218.88503
- Similarity Product: 162.6938682685721

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test