PATENT CLAIM ANALYSIS

Application Number: 16035411
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["800", "015000"]

Abstract:
A genetically modified livestock animal comprising a genomic modification to an eIF4G gene. Cells, genes, and proteins encompassing a protease-resistant eIF4G protein or gene.

Claim (Index 19):
A method of producing a gene edited cow or pig whose genome comprises a genome edited eIF4GI gene, wherein the genome edited eIF4GI gene expresses an altered eIF4GI protein relative to a wild type eIF4GI protein such that the gene edited cow or pig is resistant to cleavage by a proteinase of foot-and-mouth disease virus enzyme , the method comprising the steps of: (a) introducing into a cow or pig fibroblast (i) a TALEN pair that specifically binds to the endogenous eIF4GI gene and causes a double-stranded DNA break to inactivate the eIF4GI gene in the cow or pig fibroblast and (ii) a Homology-dependent repair (HDR) template; (b) permitting to occur homologous recombination events in the cow or pig fibroblast; (c) transferring the transfected fibroblast into an enucleated cow or pig recipient oocyte to generate a transgenic nuclear transfer embryo and activating the nuclear transfer embryo; and (d) transplanting the nuclear transfer embryo into a surrogate mother cow or pig and permitting the implanted embryo to develop such that the transgenic cow or pig whose genome comprises a genome edited eIF4GI gene is produced, wherein the cow or pig expresses the genome edited eIF4GI gene and is resistant to cleavage by the leader proteinase.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 95.0
- Lexical Diversity: 1.21739
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13836860', '15216865', '15793901', '13066801', '15259409']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4715543536942604
- 35 USC 102 Novelty (BERT): 0.5700348762990671
- Combined Prediction Score: 0.4814024059547411
- Mean Citation Score: 272.030902
- Max Citation Score: 473.48782
- Similarity Product: 396.52264186239125

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test