PATENT CLAIM ANALYSIS

Application Number: 15898434
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-08
Patent Classification: ["514", "021500"]

Abstract:
The present invention provides a compound that can be used for targeted drug delivery, imaging a patient, or diagnosing a subject for a clinical condition which is believed to be associated with overexpression and/or upregulation of CXCR4. In particular, the present invention provides a high affinity CXCR4 selective binding ligand peptide conjugate (PC) of the Formula: P-(L-A) n  (I) or a pharmaceutically acceptable salt thereof, and a method for using and producing the same. The high affinity CXCR4 selective binding ligand peptide conjugate (PC) of the invention is useful in diagnosing, treating or imaging a patient. In compound of Formula (I), n is an integer from 1 to the sum of (the total number of amino acid resides in P and the total number of side-chain functional group in the amino acid residue of P); each A is independently a diagnostic agent, a therapeutic agent, or an imaging agent; L is a linker or absent; and P is a high affinity CXCR4 selective binding peptidyl ligand. In particular, the invention provides to a targeted drug delivery or imaging a patient or diagnosing a patient for a disease of which overexpression and/or upregulation of CXCR4 is implicated, such as cancers, HIV infection, and immune disorders. Compositions and kits peptide conjugate of Formula I as well as methods for using and producing peptide conjugate of Formula I are disclosed herein.

Claim (Index 7):
The high affinity CXCR4 selective binding ligand peptide conjugate of  claim 1 , wherein said diagnostic agent is an imaging agent, an isotopic agent, or a radioactive agent.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 2.45794
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15695862', '12123574', '12280829', '14050349', '15444045']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8250935361567346
- 35 USC 102 Novelty (BERT): 0.551440660499613
- Combined Prediction Score: 0.7977282485910224
- Mean Citation Score: 399.357324
- Max Citation Score: 471.9654
- Similarity Product: 265.5011858962297

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test