PATENT CLAIM ANALYSIS

Application Number: 15555446
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["424", "145100"]

Abstract:
The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders, in particular, the present invention discloses antibodies specific for free IL-18 and IL-18 Binding Protein (IL-18BP) for use in such treatments and for the diagnosis of the diseases and disorders.

Claim (Index 80):
A method of diagnosing and treating an IL-18 associated disease or disorder comprising\n quantifying the levels of free IL-18 in a body fluid sample from a subject using an assay capable of detecting free IL-18 in body fluids, said assay comprising IL-18BP or an antibody or a functional part thereof, which antibody or active part thereof binds to IL-18 at the binding site of IL-18BP or in the vicinity of the binding site of IL-18BP, but does not bind IL-18/IL-18BP complexes; diagnosing the subject with an IL-18 associated disease or disorder when the body fluids of said subject have been quantified to have abnormal levels of free IL-18, which exceed the levels of free IL-18 in body fluids of a healthy control subject by at least 5%; administering to the subject having an IL-18 associated disease or disorder an IL-18 inhibitor or an active fragment thereof, or a composition comprising IL-18BP or an active fragment thereof; wherein said IL-18 inhibitor or composition is substantially free of N-terminal and/or C-terminal deletion variants of IL-18BP, which are present in an amount of less than 40%.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 86.0
- Lexical Diversity: 1.55882
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14017561', '15164508', '14649297', '14146566', '13676511']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.761224854174719
- 35 USC 102 Novelty (BERT): 0.530470777649014
- Combined Prediction Score: 0.7381494465221484
- Mean Citation Score: 335.13133000000005
- Max Citation Score: 364.11945
- Similarity Product: 257.6559787651866

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test