PATENT CLAIM ANALYSIS

Application Number: 16146807
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["435", "006100"]

Abstract:
Provided herein is a method of sequencing hydroxymethyated cell-free DNA. In some embodiments, the method comprises adding an affinity tag to only hydroxymethyated DNA molecules in a sample of cfDNA, enriching for the DNA molecules that are tagged with the affinity tag; and sequencing the enriched DNA molecules.

Claim (Index 4):
The method of  claim 3 , wherein the capture tag is added to 5-hydroxymethylcytosine residues in the cfDNA in step (a)(ii) by a method comprising: incubating the adaptor-ligated cfDNA with a DNA \u03b2-glucosyltransferase and UDP glucose modified with a chemoselective group, thereby covalently binding the chemoselective group to 5hmC residues in the cfDNA; and reacting a biotin moiety with the chemoselective group to provide biotinylated, hydroxymethylated cfDNA.

Metadata:
- Claim Count in Document: 54.0
- Percentile: 97.0
- Lexical Diversity: 1.47222
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14983379', '13555037', '13009718', '12958353', '13600043']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5470322483796026
- 35 USC 102 Novelty (BERT): 0.5141852433482939
- Combined Prediction Score: 0.5437475478764717
- Mean Citation Score: 238.7877
- Max Citation Score: 248.1314
- Similarity Product: 132.93528133542534

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test