PATENT CLAIM ANALYSIS

Application Number: 15753318
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "440000"]

Abstract:
Chromatin 3D structure modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs, such as CTCF motifs. In certain example embodiments, the present invention may block formation of an loop anchor or chromatin domain or induce formation of a loop anchor or chromatin domain at a targeted genomic location. For instance, a loop anchor motif can be altered, such as by mutating (including inverting) a binding motif so as to remove such a motif, or by adding new binding motifs in new locations within a loop domain, so as to reduce the size of an existing loop, so as to modify the size of an existing loop, or combinations thereof. Alternatively, the chromatin 3D structure modulating agent may bind a target region and mask a loop anchor motif, thereby preventing a loop anchor or chromatin domain from forming. The chromatin 3D structure modulating agent may bind a target region and cause a loop anchor of chromatin domain to form.

Claim (Index 13):
The method of  claim 1 , wherein the CTCF or cohesin binding motif is the CTCF motif, and/or\n wherein said contact domain is an exclusion domain, and wherein said exclusion domain is introduced by inserting, or deleted by deleting, a CTCF or cohesin binding motif downstream or upstream from adjacent CTCF or cohesin binding motifs in convergent orientation, and/or wherein the extrusion complex comprises one or more members selected from the group consisting of CTCF, SA1/2, Smc3, Smc1, cohesin and Rad21, and/or wherein said target region comprises genes the expression of which is to be modified, preferably wherein said proximity to the target region is less than 1000 base pairs, and/or wherein said target region is located in or overlaps with an existing chromatin loop or contact domain, or wherein said target region is to be formed into or is to be made part of a new chromatin loop or contact domain.

Metadata:
- Claim Count in Document: 72.0
- Percentile: 88.0
- Lexical Diversity: 2.30864
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14892911', '14916338', '15179912', '14105017', '15527790']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5686381422025739
- 35 USC 102 Novelty (BERT): 0.5120870031864944
- Combined Prediction Score: 0.562983028300966
- Mean Citation Score: 257.984156
- Max Citation Score: 263.11386
- Similarity Product: 154.38375912787913

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test