PATENT CLAIM ANALYSIS

Application Number: 16218588
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-09
Patent Classification: ["514", "04400A"]

Abstract:
The invention relates to methods, processes and apparatuses for the manufacture of lipid nanoparticles having a therapeutic payload.

Claim (Index 1):
A method of preparing a formulation comprising lipid nanoparticles comprising an RNAi agent payload comprising;\n (a) mixing a first solution with a second solution in a mixing connector, wherein\n (i) said first solution comprises an ethanolic solution comprising one or more lipids and having a total lipid concentration of approximately 30 mg/mL, and \n (ii) said second solution comprises citrate buffered aqueous solution comprising one or more RNAi agents and having an RNAi agent concentration of approximately 1 mg/mL and a pH of between 3 and 6, and \n (b) diluting the mixture produced in (a) in a vessel containing a buffer solution thereby producing a formulation comprising lipid nanoparticles comprising an RNAi agent payload; wherein the linear flow rate of said first solution into the mixing connector is approximately 606,267 cm/h and the linear flow rate of said second solution into the mixing connector is approximately 1,818,801 cm/h and the volume ratio of said first solution to said second solution is approximately 1:3.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 98.0
- Lexical Diversity: 1.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15023919', '15326291', '13669217', '11495150', '12965555']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7110707184183432
- 35 USC 102 Novelty (BERT): 0.5557240913586436
- Combined Prediction Score: 0.6955360557123733
- Mean Citation Score: 219.232654
- Max Citation Score: 413.18713
- Similarity Product: 398.9563081475292

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test