PATENT CLAIM ANALYSIS

Application Number: 16125401
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["546", "153000"]

Abstract:
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine (AL3818). A stable crystalline form of Al3818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I.

Claim (Index 6):
A method of treating a neoplastic disease, said method comprising:\n administering to a patient in need thereof a salt of 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquino-lin-7-yloxy)-methyl)-cyclopropanamine; and administering a second therapeutic agent to the patient; wherein the 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquino-lin-7-yloxy)-methyl)-cyclopropanamine salt is selected from: a bishydrochloride acid salt, a bishydrochloridehydrate acid salt, a bismaleic acid salt and a succinic acid salt; wherein the neoplastic disease comprises solid tumors, selected from lung, renal, colorectal, gastric, melanoma, head/neck, thyroid, pancreatic, liver, prostate, bladder, brain, sarcoma, breast, ovarian, cervical and endometrial cancers; and blood cancers, selected from ALL, CLL, AML, CML and Multiple Myeloma.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 97.0
- Lexical Diversity: 1.52174
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15659510', '15143630', '14760549', '12036244', '15460633']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7622633906926725
- 35 USC 102 Novelty (BERT): 0.5917343825074054
- Combined Prediction Score: 0.7452104898741457
- Mean Citation Score: 366.803362
- Max Citation Score: 538.4721
- Similarity Product: 420.86257106475233

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test