PATENT CLAIM ANALYSIS

Application Number: 15985479
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["424", "450000"]

Abstract:
A temsirolimus liposome and preparation method thereof is provided. The formulation of the present invention contains temsirolimus, a phospholipid, a PEGylated phospholipid, and can further contain cholesterol, a stabilizer and a lyoprotectant. In view of the unique physicochemical properties of temsirolimus, the present invention performed a matching study on the formulation composition and preparation process, and developed a temsirolimus liposome, preferably a lyophilized powder injection, which is safe, stable in quality, simple in preparation process, and can be industrially produced. The preparation overcomes the disadvantages of poor safety, stability and the like in the existing preparations, establishing a solid foundation for the further study and application of temsirolimus in the anti-tumor field.

Claim (Index 10):
A preparation method of the temsirolimus liposome composition according to  claim 1 , characterized in that, the steps thereof are as follows:\n taking temsirolimus, a phospholipid, a PEGylated phospholipid, cholesterol and a stabilizer, adding quantum satis organic vehicle thereto, and dissolving them by heating at 25-75\u00b0 C. to give an organic phase; subjecting the organic phase to a rotary evaporation to remove the organic vehicle at 25-75\u00b0 C., or placing the organic phase in a sample plate and lyophilizing it to give a lipid phase; weighing quantum satis water for injection and heating it to 25-75\u00b0 C., so as to give an aqueous phase; adding the aqueous phase to the lipid phase, and stirring them to give a crude liposome; emulsifying the crude liposome, which can be homogenized and emulsified by placing it in a high-pressure homogenizer, or extruded successively through extrusion membranes with different pore sizes by placing it in an extruder, or extruded after high-pressure homogenization, so as to give a liposome solution; weighing a formula amount of a lyoprotectant, placing it in the liposome solution, dissolving it with stirring and setting the volume thereof to full volume with water for injection; adjusting pH value with a pH regulator; filtering and sterilizing through a 0.22 \u03bcm filter membrane, sub-packaging, lyophilizing and sealing, and thus obtaining temsirolimus liposome lyophilized powder injection, wherein the organic vehicle is selected from one or two or more of ethanol, dichloromethane, chloroform, methanol, acetonitrile, tert-butanol, ethylpropanediol and methanol.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 93.0
- Lexical Diversity: 1.92537
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15138527', '13819407', '10398222', '15300688', '14653234']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7453333316613014
- 35 USC 102 Novelty (BERT): 0.5028370027688667
- Combined Prediction Score: 0.721083698772058
- Mean Citation Score: 227.909042
- Max Citation Score: 236.55312
- Similarity Product: 158.61953578147887

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test