PATENT CLAIM ANALYSIS

Application Number: 16393793
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-09
Patent Classification: ["514", "299000"]

Abstract:
The present invention provides methods and pharmaceutical compositions for treating proliferative disorders.

Claim (Index 52):
A method of treating cancer in a subject in need thereof, comprising administering to the subject an effective amount of a HIF-2\u03b1 inhibitor in combination with an immunotherapeutic agent, wherein the cancer is selected from the group consisting of non-small cell lung carcinoma, prostate cancer, hepatocellular carcinoma, squamous cell carcinoma of the head and neck, carcinomas of the esophagus, ovary, gastrointestinal tract and breast, and a hematologic malignancy, and breast cancer, and wherein the HIF-2\u03b1 inhibitor is a compound of Formula I-C: or a pharmaceutically acceptable salt thereof, wherein:\n X is CR 5  or N; \n Y is CR 6  or N; \n Z is \u2014O\u2014, \u2014S\u2014, \u2014C(HR)\u2014, \u2014N(R 8 )\u2014 or absent; \n R 1  is alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; \n R 4  is nitro, halo, cyano, alkyl, cycloalkyl, heteroaryl, carboxyl, sulfinyl, sulfonamidyl, sulfonyl or sulfoximinyl; \n R 5 , R 6 , R 7  and R 8  are independently hydrogen, halo, hydroxy, cyano, alkyl or alkoxy; \n R 11  is hydroxy, alkoxy or amino; \n R 12  is hydrogen, alkyl, alkenyl or alkynyl; or R 11  and R 12  in combination form oxo or oxime; \n each of R 13  is independently selected from the group consisting of hydrogen, fluoro, chloro, hydroxy, alkyl and heteroalkyl; or two R 13 s and the carbon atom(s) to which they are attached form a 3- to 8-membered cycloalkyl or heterocycloalkyl moiety; and \n n is 0, 1, 2, 3 or 4.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 100.0
- Lexical Diversity: 1.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15564348', '15556609', '15553570', '15556607', '15805390']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7765971162365926
- 35 USC 102 Novelty (BERT): 0.6165739311421203
- Combined Prediction Score: 0.7605947977271453
- Mean Citation Score: 472.4451700000001
- Max Citation Score: 600.1395
- Similarity Product: 479.7029938593506

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test