PATENT CLAIM ANALYSIS

Application Number: 15759600
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-02
Patent Classification: ["514", "255060"]

Abstract:
Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the progression of AIDS and general immunosuppression.

Claim (Index 72):
A compound or pharmaceutically acceptable salt thereof selected from the group consisting of:\n a. 3-(3-(benzo[d]oxazol-2-ylamino)-4-(diisobutylamino)phenyl)butanoic acid b. 3-(3-((1H-benzo[d]imidazol-2-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid c. 3-(4-(diisobutylamino)-3-((4-phenyloxazol-2-yl)amino)phenyl)butanoic acid d. 3-(4-(diisobutylamino)-3-((4-isopropyloxazol-2-yl)amino)phenyl)butanoic acid e. 3-(4-(diisobutylamino)-3-((4-(trifluoromethyl)oxazol-2-yl)amino)phenyl)butanoic acid f. 3-(3-((1H-benzo[d]imidazol-2-yl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid g. 3-(3-((3-chloro-1,2,4-thiadiazol-5-yl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid h. 3-(3-(benzo[d]oxazol-2-ylamino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid i. 3-(3-(benzo[d]thiazol-2-ylamino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid j. 3-(4-(cyclohexyl(isobutyl)amino)-3-((4-phenyloxazol-2-yl)amino)phenyl)butanoic acid k. 3-(3-((2-chloropyrimidin-4-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid, 2,2,2-trifluoroacetic acid salt l. 3-(4-(diisobutylamino)-3-((2-methoxypyrimidin-4-yl)amino)phenyl)butanoic acid, 2,2,2-trifluoroacetic acid salt m. 3-(3-((2-chloropyrimidin-4-yl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid n. 3-(4-(cyclohexyl(isobutyl)amino)-3-((2-methoxypyrimidin-4-yl)amino)phenyl)butanoic acid o. 3-(4-(diisobutylamino)-3-((5-methylthiazol-2-yl)amino)phenyl)butanoic acid p. 3-(4-(diisobutylamino)-3-((2-phenylthiazol-5-yl)amino)phenyl)butanoic acid q. 3-(4-(diisobutylamino)-3-((2-(ethoxycarbonyl)thiazol-5-yl)amino)phenyl)butanoic acid r. 3-(4-(diisobutylamino)-3-(pyridin-4-ylamino)phenyl)butanoic acid s. 3-(4-(cyclohexyl(isobutyl)amino)-3-(cyclohexylamino)phenyl)butanoic acid t. 3-(4-(cyclohexyl(isobutyl)amino)-3-((thiophen-2-ylmethyl)amino)phenyl)butanoic acid u. 3-(4-(cyclohexyl(isobutyl)amino)-3-((thiazol-2-ylmethyl)amino)phenyl)butanoic acid v. 3-(4-(cyclohexyl(isobutyl)amino)-3-((thiazol-5-ylmethyl)amino)phenyl)butanoic acid w. 3-(4-(cyclohexyl(isobutyl)amino)-3-((2-methylbenzyl)amino)phenyl)butanoic acid x. 3-(4-(diisobutylamino)-3-((4-methylthiazol-2-yl)amino)phenyl)butanoic acid y. 3-(3-((3-chloro-1,2,4-thiadiazol-5-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid z. 3-(3-((5-cyclopropyl-1,3,4-thiadiazol-2-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid, 2,2,2-trifluoroacetic acid salt aa. 3-(4-(diisobutylamino)-3-((5-phenyl-1,3,4-thiadiazol-2-yl)amino)phenyl)butanoic acid bb. 3-(4-(diisobutylamino)-3-((5-methyl-1,3,4-thiadiazol-2-yl)amino)phenyl)butanoic acid cc. 3-(4-(cyclohexyl(isobutyl)amino)-3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)phenyl)butanoic acid dd. 3-(3-((3-cyclopropyl-1,2,4-thiadiazol-5-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid ee. 3-(4-(diisobutylamino)-3-((3-methyl-1,2,4-thiadiazol-5-yl)amino)phenyl)butanoic acid ff. 3-(3-((3-bromo-1,2,4-thiadiazol-5-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid gg. 3-(4-(cyclohexyl(isobutyl)amino)-3-((3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl)amino)phenyl)butanoic acid hh. 3-(4-(diisobutylamino)-3-((3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl)amino)phenyl)butanoic acid ii. 3-(3-(benzo[d]oxazol-2-ylamino)-5-butyl-4-propoxyphenyl)butanoic acid jj. 3-(3-butyl-5-((3-chloro-1,2,4-thiadiazol-5-yl)amino)-4-propoxyphenyl)butanoic acid, 2,2,2-trifluoroacetic acid salt kk. (S)-3-(4-(cyclohexyl(isobutyl)amino)-3-((3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl)amino)phenyl)butanoic acid ll. (R)-3-(4-(cyclohexyl(isobutyl)amino)-3-((3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl)amino)phenyl)butanoic acid mm. (S)-3-(3-((3-chloro-1,2,4-thiadiazol-5-yl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid nn. (R)-3-(3-((3-chloro-1,2,4-thiadiazol-5-yl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid oo. (S)-3-(3-((3-chloro-1,2,4-thiadiazol-5-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid pp. (R)-3-(3-((3-chloro-1,2,4-thiadiazol-5-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid qq. 3-(4-(diisobutylamino)-3-((4,5-dimethylthiazol-2-yl)amino)phenyl)butanoic acid rr. 3-(4-(diisobutylamino)-3-((4-(trifluoromethyl)thiazol-2-yl)amino)phenyl)butanoic acid ss. 3-(4-(diisobutylamino)-3-((5-methyl-4-(trifluoromethyl)thiazol-2-yl)amino)phenyl)butanoic acid tt. 3-(4-(diisobutylamino)-3-((4-isopropylthiazol-2-yl)amino)phenyl)butanoic acid uu. 3-(4-(diisobutylamino)-3-((5-methyl-4H-1,2,4-triazol-3-yl)amino)phenyl)butanoic acid vv. 3-(3-((5-cyclopropyl-4H-1,2,4-triazol-3-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid ww. (R)-3-(4-(cyclohexyl(isobutyl)amino)-3-((4-(trifluoromethyl)thiazol-2-yl)amino)phenyl)butanoic acid xx. (R)-3-(4-(cyclohexyl(isobutyl)amino)-3-((5-cyclopropyl-4H-1,2,4-triazol-3-yl)amino)phenyl)butanoic acid yy. 3-(4-(diisobutylamino)-3-((3-phenyl-1,2,4-oxadiazol-5-yl)amino)phenyl)butanoic acid zz. 3-(3-((3-bromo-1,2,4-thiadiazol-5-yl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid aaa. (S)-3-(4-(diisobutylamino)-3-((3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl)amino)phenyl)butanoic acid bbb. (R)-3-(4-(diisobutylamino)-3-((3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl)amino)phenyl)butanoic acid ccc. 3-(4-(diisobutylamino)-3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)phenyl)butanoic acid, 2,2,2-trifluoroacetic acid salt ddd. (R)-3-(4-(cyclohexyl(isobutyl)amino)-3-((5-cyclopropyl-1,3,4-thiadiazol-2-yl)amino)phenyl)butanoic acid eee. (S)-3-(4-(cyclohexyl(isobutyl)amino)-3-((5-cyclopropyl-1,3,4-thiadiazol-2-yl)amino)phenyl)butanoic acid fff. 3-(4-(diisobutylamino)-3-(pyrazin-2-ylamino)phenyl)butanoic acid ggg. 3-(4-(cyclohexyl(isobutyl)amino)-3-((furan-2-ylmethyl)amino)phenyl)butanoic acid hhh. 3-(4-(diisobutylamino)-3-((4-methyl-2-(trifluoromethyl)thiazol-5-yl)amino)phenyl)butanoic acid iii. 3-(3-((2-cyclopropylthiazol-5-yl)amino)-4-(diisobutylamino)phenyl)butanoic acid jjj. (S)-3-(3-((2-chloropyrimidin-4-yl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid kkk. (R)-3-(3-((2-chloropyrimidin-4-yl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid lll. (R)-3-(4-(cyclohexyl(isobutyl)amino)-3-(cyclohexylamino)phenyl)butanoic acid mmm. 3-(4-(cyclohexyl(isobutyl)amino)-3-((3-(trifluoromethyl)phenyl)amino)phenyl)butanoic acid nnn. 3-(4-(cyclohexyl(isobutyl)amino)-3-((4-(trifluoromethyl)phenyl)amino)phenyl)butanoic acid ooo. 3-(3-((4-cyanophenyl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid ppp. 3-(4-(cyclohexyl(isobutyl)amino)-3-(phenylamino)phenyl)butanoic acid qqq. 3-(3-(benzylamino)-4-(cyclohexyl(isobutyl)amino)phenyl)butanoic acid rrr. 3-(4-(cyclohexyl(isobutyl)amino)-3-((tetrahydro-2H-pyran-4-yl)amino)phenyl)butanoic acid sss. 3-(3-((3-chloro-1,2,4-thiadiazol-5-yl)amino)-4-(cyclohexyl(isobutyl)amino)phenyl)-4,4,4-trifluorobutanoic acid ttt. 3-(4-(cyclohexyl(isobutyl)amino)-3-(((R)-4-phenyl-4,5-dihydrooxazol-2-yl)amino)phenyl)butanoic acid uuu. 3-(4-(cyclohexyl(isobutyl)amino)-3-(((S)-4-methyl-4,5-dihydrothiazol-2-yl)amino)phenyl)butanoic acid vvv. 3-(4-(cyclohexyl(isobutyl)amino)-3-(((R)-4-methyl-4,5-dihydrothiazol-2-yl)amino)phenyl)butanoic acid www. 3-(4-(cyclohexyl(isobutyl)amino)-3-(((R)-4-(trifluoromethyl)-4,5-dihydrothiazol-2-yl)amino)phenyl)butanoic acid xxx. 3-(4-(cyclohexyl(isobutyl)amino)-3-(((R)-4-(trifluoromethyl)-4,5-dihydrooxazol-2-yl)amino)phenyl)butanoic acid.

Metadata:
- Claim Count in Document: 36.0
- Percentile: 90.0
- Lexical Diversity: 1.43333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15759950', '15737798', '10311385', '15088211', '15584818']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8261018993518481
- 35 USC 102 Novelty (BERT): 0.5964357742166926
- Combined Prediction Score: 0.8031352868383326
- Mean Citation Score: 384.189
- Max Citation Score: 526.85803
- Similarity Product: 468.28038013614713

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test