PATENT CLAIM ANALYSIS

Application Number: 15957858
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["424", "448000"]

Abstract:
A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.

Claim (Index 38):
A composition, comprising:\n a drug reservoir comprised of a donepezil salt, a pharmaceutically acceptable alkaline salt, a solvent composition comprising a hydrophilic solvent, and an acrylate copolymer; and a skin contact adhesive comprising one or more of (i) triethyl citrate, (ii) sorbitan monolaurate, and (iii) lauryl lactate, wherein reaction of the donepezil salt and the alkaline salt generates a therapeutically effective amount of donepezil base in situ in the drug reservoir when the skin contact adhesive is attached to skin of a subject.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 91.0
- Lexical Diversity: 1.48214
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15660939', '15660943', '15660933', '13503198', '11797722']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8295382755860348
- 35 USC 102 Novelty (BERT): 0.6490180850968601
- Combined Prediction Score: 0.8114862565371173
- Mean Citation Score: 499.857758
- Max Citation Score: 644.9519
- Similarity Product: 581.8083198751568

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test