PATENT CLAIM ANALYSIS

Application Number: 16222951
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-07
Patent Classification: ["800", "006000"]

Abstract:
Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human V H  gene segment, a plurality of human D H  gene segments and a plurality of human J H  gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

Claim (Index 55):
A method for modifying an immunoglobulin heavy chain locus of a mouse, comprising:\n (a) making a first modification of the mouse immunoglobulin heavy chain locus, wherein the first modification comprises an insertion of one or more unrearranged human immunoglobulin gene sequences at the mouse immunoglobulin heavy chain locus, including a single human V H  gene segment, one or more D H  gene segments, and one or more J H  gene segments, wherein the single human V H  gene segment, one or more D H  gene segments, and one or more J H  gene segments are operably linked with a mouse immunoglobulin heavy chain constant region gene at the endogenous immunoglobulin heavy chain locus, wherein the single human V H  gene segment is V H 1-2 or a polymorphic variant thereof, wherein the insertion disrupts the function of an endogenous ADAM6 protein, and wherein the disruption of the endogenous ADAM6 function is associated with a reduction in fertility in male mice; and (b) making a second modification of the mouse which comprises an insertion of a mouse ADAM6 sequence upstream of the single human V H  gene segment, wherein the mouse ADAM6 sequence encodes a mouse ADAM6 protein that is functional in a male mouse, wherein the functional mouse ADAM6 protein is expressed when the mouse is a male mouse such that the male mouse has wild-type fertility.

Metadata:
- Claim Count in Document: 77.0
- Percentile: 98.0
- Lexical Diversity: 2.06557
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13788997', '13566765', '14682859', '15585023', '16059884']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6163146362003536
- 35 USC 102 Novelty (BERT): 0.6243416377623561
- Combined Prediction Score: 0.6171173363565539
- Mean Citation Score: 516.7685819999998
- Max Citation Score: 595.55
- Similarity Product: 559.8399299949408

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test