PATENT CLAIM ANALYSIS

Application Number: 16101882
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["514", "375000"]

Abstract:
It is provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis. It is also provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis in combination therapy with another COMT inhibitor, a benzoxazole derivative, iododiflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxocycline, or epigallocatechin-3-gallate.

Claim (Index 19):
The method of  claim 14 , wherein an additional therapeutic agent is administered in combination with the catechol-O-methyltransferase (COMT) inhibitor, and wherein the additional therapeutic agent is selected from the group consisting of another COMT inhibitor as defined in claim  1 , a benzoxazole derivative, iododiflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxocycline and epigallocatechin-3-gallate, wherein the benzoxazole derivative is a compound of formula V or a pharmaceutically acceptable salt thereof, wherein: Y is selected from the group consisting of COOR, tetrazolyl, CONHOR, B(OH) 2  and OR; X is O; and R 1 , R 2  and R 3  are each independently selected from the group consisting of hydrogen, halo, OR, B(OH) 2  and CF 3 , and wherein R is selected from the group consisting of hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkenyl, C 1 -C 6  alkynyl, C 1 -C 6  cycloalkyl, C 1 -C 6  heterocyclyl, phenyl, xylyl, naphthyl, thienyl, indolyl and pyridyl.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 96.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14353459', '15448054', '15736826', '13830731', '15480139']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8152367794966201
- 35 USC 102 Novelty (BERT): 0.6682060502802333
- Combined Prediction Score: 0.8005337065749815
- Mean Citation Score: 485.68719
- Max Citation Score: 735.84143
- Similarity Product: 612.3810470026148

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test