PATENT CLAIM ANALYSIS

Application Number: 16179322
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-02
Patent Classification: ["424", "204100"]

Abstract:
A method for producing AAV, without requiring cell lysis, is described. The method involves harvesting AAV from the supernatant. For AAV having capsids with a heparin binding site, the method involves modifying the AAV capsids and/or the culture conditions to ablate the binding between the AAV heparin binding site and the cells, thereby allowing the AAV to pass into the supernatant, i.e., media. Thus, the method of the invention provides supernatant containing high yields of AAV which have a higher degree of purity from cell membranes and intracellular materials, as compared to AAV produced using methods using a cell lysis step.

Claim (Index 20):
The method according to  claim 19 , wherein the heparin binding site is characterized by the amino acid sequence RxxR (SEQ ID NO: 12), where x is any amino acid.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 98.0
- Lexical Diversity: 1.79365
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14919801', '12226588', '13884914', '10511980', '10798192']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7248053682340447
- 35 USC 102 Novelty (BERT): 0.5632426415404719
- Combined Prediction Score: 0.7086490955646875
- Mean Citation Score: 317.796398
- Max Citation Score: 426.3658
- Similarity Product: 361.39369330852026

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test