PATENT CLAIM ANALYSIS

Application Number: 15751943
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "469000"]

Abstract:
Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein.

Claim (Index 5):
A compound of Formula (V): or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is hydrogen, halogen, or optionally substituted alkyl; \n each instance of R 3  is independently halogen, \u2014CN, \u2014NO 2 , \u2014N 3 , optionally substituted alkyl, \u2014OR 3A , \u2014N(R 3B ) 2 , or optionally substituted acyl; \n each instance of R 3A  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or an oxygen protecting group; and \n each instance of R 3B  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group, or two R 3B  taken together with the intervening atoms to form optionally substituted heterocyclyl. \n n is 0, 1, 2, 3, 4, or 5; \n R 4  is hydrogen, optionally substituted alkyl, or a nitrogen protecting group; \n R 7  is hydrogen, halogen, \u2014CN, \u2014NO 2 , \u2014N 3 , optionally substituted alkyl, \u2014OR 7A , \u2014N(R 7B ) 2 , or optionally substituted acyl; \n R 7A  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or an oxygen protecting group; and \n each instance of R 7B  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group, or two R 7B  are taken together with the intervening atoms form optionally substituted heterocyclyl. \n R 8  is hydrogen, halogen, \u2014CN, \u2014NO 2 , \u2014N 3 , optionally substituted alkyl, \u2014OR 8A , \u2014N(R 8B ) 2 , or optionally substituted acyl; \n R 8A  is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or an oxygen protecting group; \n each instance of R 8B  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group, or two R 8B  are taken together with the intervening atoms to form optionally substituted heterocyclyl; and \n each instance of R N  is independently hydrogen, optionally substituted alkyl, \u2014OR NA , \u2014N(R NB ) 2 , or a nitrogen protecting group, or two R N  taken together with the intervening atoms form optionally substituted heterocyclyl; \n R NA  is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or an oxygen protecting group; and \n each instance of R NB  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group, or two R NB  are taken together with the intervening atoms to form optionally substituted heterocyclyl; \n provided that at least one instance of R N  is not hydrogen, \u2014OH, or \u2014NH 2 .

Metadata:
- Claim Count in Document: 16.0
- Percentile: 88.0
- Lexical Diversity: 1.7971
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16095188', '15327705', '15737683', '15737535', '15327690']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8352684753758056
- 35 USC 102 Novelty (BERT): 0.5679154845113871
- Combined Prediction Score: 0.8085331762893637
- Mean Citation Score: 449.84217
- Max Citation Score: 452.49582
- Similarity Product: 368.9906080396271

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test