PATENT CLAIM ANALYSIS

Application Number: 15971496
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "603000"]

Abstract:
A method for the treatment and/or reduction of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is disclosed. The method uses active amino-aryl-benzamide compounds and methods for the preparation thereof.

Claim (Index 1):
A method of treating nonalcoholic fatty liver disease (NAFLD) in a subject, comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of a compound of Formula I, Formula II, Formula III, Formula IV or a prodrug, therapeutically active metabolite, hydrate, solvate, or pharmaceutically acceptable salt thereof, wherein,\n Formula I is: wherein R1 is a halogen, R2 is a sulfoxide group, and R3 and R4 are independently hydrogen or lower alkyl; wherein, Formula II is: Formula III is: wherein, R 1  is \u2014CHCHR 5 ; \u2014CHCHCO 2 R 5 ; \u2014CHCHCONHR 5 ; -phenyl; -phenyl-R 5 ; \u2014CCR 5 ; \u2014CC\u2014CH 2 R 5 ; \u2014OR 5 ; \u2014SR 5 ; or \u2014NHR 5 ; R 2  is \u2014C 6 H 5 \u2014R 6 ; \u2014OC 6 H 5 \u2014R 6 ; \u2014SC 6 H 5 \u2014R 6 ; \u2014NHC 6 H 5 \u2014R 6 ; \u2014OC 1-6  alkyl-C 6 H 4 \u2014R 6 ; \u2014NHC 1-6  alkyl-C 6 H 4 \u2014R 6 ; piperazine-R6; or pyridine-R6; R 3  is H; \u2014C 1-6  alkyl optionally substituted with \u2014OH, \u2014NH 2 , phenyl, or halogen; \u2014CO-pyridine; \u2014CO\u2014CH 2 CH 2 NH 2 ; or \u2014CO\u2014C 1-6  alkyl optionally substituted with \u2014OH or \u2014NH 2 ; R 4  is H; \u2014OCH 3 ; -piperidine; -piperidine-CONH 2 ; -pyridine; -pyrrole; -thiophene; \u2014C 1-6  alkyl optionally substituted with \u2014OH; -pyridine; -piperidine; -pyrrole; -thiophene; or -phenyl optionally substituted with halogen or hydroxy; or, R 3  and R 4  together form uracil; R 5  is halogen; \u2014COOH; C 1-6  cycloalkyl; \u2014CH 2 C 6 H 5 ; \u2014CH 2 CH 2 C 6 H 5 ; \u2014CH 2 CH 2 C 6 H 5 \u2014F; CH 2 C 6 H 5 \u2014COOH; \u2014CH 2 C 6 H 5 \u2014OH; \u2014CH 2 -furan; \u2014Si(CH 2 ) 3 ; \u2014CH 2 CO 2 CH 3 ; \u2014CH 2 CO 2 (CH 2 ) 2 CH 3 ; or \u2014CH 2 CO 2 C 6 H 5 \u2014Cl; or \u2014C 1-10  alkyl optionally substituted with halogen or \u2014OH; or \u2014C 1-10  cycloalkyl optionally substituted with halogen or \u2014OH; or -phenyl optionally substituted with halogen, \u2014OH, \u2014CH 3 , \u2014C 1-10  alkyl, OCO\u2014C 1-4  alkyl, \u2014NHCOMe, \u2014NHCO(CH 2 ) 2 CH 3 , \u2014COOH, \u2014OC 1-10  alkyl, or \u2014CO 2 \u2014C 1-4  alkyl; or -pyridine optionally substituted with halogen, \u2014OH, \u2014CH 3 , \u2014C 1-10  alkyl, OCO\u2014C 1-4  alkyl, \u2014NHCOMe, \u2014NHCO(CH 2 ) 2 CH 3 , \u2014COOH, \u2014OC 1-10  alkyl, or \u2014CO 2 \u2014C 1-4  alkyl; or -pyrrole optionally substituted with halogen, \u2014OH, \u2014CH 3 , \u2014C 1-10  alkyl, OCO\u2014C 1-4  alkyl, \u2014NHCOMe, \u2014NHCO(CH 2 ) 2 CH 3 , \u2014COOH, \u2014OC 1-10  alkyl, or \u2014CO 2 \u2014C 1-4  alkyl; R 6  is \u2014SO 2 NH 2 ; \u2014OPO(OH) 2 ; \u2014NH 2 ; \u2014NHCONH 2 ; \u2014NHCOCH 3 ; \u2014NHCSCH 3 ; \u2014NHCSCH 2 CH 3 ; \u2014NHCS(CH 2 ) 2 CH 3 ; tetrazole; \u2014SO 2 NH(CH 2 ) 2 CH 3 ; \u2014NHC(NH)NH 2 ; \u2014NHCSNH 2 ; \u2014NHCSCH 2 OH; triazole; oxoimidazol; \u2014SO 2 NHCH 2 CH 2 OH; \u2014NHCONH\u2014C 1-6  alkyl; or \u2014NHCONH-pyridine; wherein, Formula IV is: wherein R1 is selected from the groups listed in Table 1; R2 is selected from the groups listed in Table 2; R3 is selected from the groups listed in Table 3; and R4 is selected from the groups listed in Table 4. TABLE 1 Formula IV, R1 Options                                                                                                                                 TABLE 2 Formula IV, R2 Options                                       TABLE 3 Formula IV, R3 Options             TABLE 4 Formula IV, R4 Options

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.27586
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13180144', '12143664', '13141310', '15263033', '15778207']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7791809871968268
- 35 USC 102 Novelty (BERT): 0.5212526763295784
- Combined Prediction Score: 0.753388156110102
- Mean Citation Score: 317.843784
- Max Citation Score: 333.9717
- Similarity Product: 261.91542163687353

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test