PATENT CLAIM ANALYSIS

Application Number: 15862535
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "021300"]

Abstract:
The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on binding of dynamin-1-related protein (Drp1) GTPase activity, Drp1 to mitochondrial fission 1 protein (Fis1), reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture.

Claim (Index 19):
The method of  claim 18 , wherein the carrier peptide comprises a peptide selected from the group consisting of SEQ ID NO: 31, SEQ ID NO:32 and SEQ ID NO:33.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 86.0
- Lexical Diversity: 1.84615
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13471221', '14271301', '15647154', '14988403', '15710696']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8801763660907209
- 35 USC 102 Novelty (BERT): 0.6004266882640956
- Combined Prediction Score: 0.8522013983080584
- Mean Citation Score: 647.569226
- Max Citation Score: 744.7003
- Similarity Product: 430.8929514796972

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test