PATENT CLAIM ANALYSIS

Application Number: 15749584
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "230200"]

Abstract:
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV.

Claim (Index 1):
A compound of Formula I wherein: R 1  is selected from hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (alkoxy)alkoxyalkyl, ((cycloalkyl)alkoxy)alkyl, (cycloalkoxy)alkyl, haloalkoxyalkyl, (haloalkoxy)alkoxyalkyl, ((halocycloalkyl)alkoxy)alkyl, (halocycloalkoxy)alkyl, (halophenoxy)alkyl, (Ar 1 )alkyl, (Ar 2 )alkyl, ((R 10 )(R 11 )N)alkyl, (trialkylammonium)alkyl, (R 6 )alkyl, alkenyl, (alkoxy)alkenyl, hydroxy, alkoxy, (Ar 1 )alkoxy, (R 10 )(R 11 )N, CO 2 R 10 , CON(R 10 )(R 11 ), ((Ar 1 )alkyl)imidazolyl, or halobenzimidazolyl; provided that when R 1  is hydrogen R 5  is not alkyl; R 2  is selected from halo, phenyl or tetrahydroisoquinolinyl and is substituted with 1 R 7  substituent and with 0-3 substituents selected from halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; provided that when R 2  is halo, R 1  and R 5  are not simultaneously alkyl; R 3  is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or homopiperidinyl substituted with 0-3 halo or alkyl substituents; R 4  is selected from alkyl or haloalkyl; R 5  is selected from hydrogen, alkyl, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, (alkoxy)alkoxyalkyl, (((alkoxy)alkoxy)alkoxy)alkyl, ((benzyloxy)alkoxy)alkyl, ((R 10 )(R 11 )N)alkyl, or (R 6 )alkyl; provided that R 1  and R 5  are not simultaneously alkyl; R 6  is selected from (oxetanyl)alkyl, ((oxetanyl)alkoxy)alkyl, (tetrahydropyranyloxy)alkyl, (tetrahydropyranyl)alkoxy)alkyl, ((pyrrolidinonyl)alkoxy)alkyl, (Ar 1 O)alkyl, ((Ar 1 )alkoxy)alkyl, ((Ar 2 )alkoxy)alkyl, (oxetanyl)oxy, ((R 8 )(R 9 )N)alkoxy, alkylthio, alkylsulfonyl, or (R 8 )(R 9 )N; R 7  is selected from (Ar 1 )alkyl, (Ar 1 )alkoxy, N-alkoxycarbonyl, or ((Ar 1 )alkyl)HNCO; or R 7  is selected from pyrimidinyl, benzofuropyrimidinyl, or pyrazolopyrimidinyl substituted with 0-1 alkyl substituents; R 8  is selected from hydrogen, alkyl, (cycloalkyl)alkyl, alkoxyalkyl, (tetrahydropyanyl)alkyl, tetrahydropyanyl, or alkoxyphenyl; R 9  is selected from hydrogen or alkyl; or (R 8 )(R 9 )N taken together is selected from azetidinyl, pyrrolidinyl, piperidinyl, (spirocyclobutyl)piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, or dioxidothiomorpholinyl, and is substituted with 0-3 alkyl or alkoxycarbonyl substituents; R 10  is selected from hydrogen, alkyl, or alkoxyalkyl; R 11  is selected from hydrogen, alkyl, (cycloalkyl)alkyl, hydroxyalkyl, alkoxyalkyl, (oxetanyl)alkyl, (tetrahydropyanyl)alkyl, (Ar 1 )alkyl, (Ar 2 )alkyl, (((Ar 1 )alkyl)carbonyl)alkyl, oxetanyl, Ar 1 , formyl, alkylcarbonyl, (Ar 2 )carbonyl, (dialkylamino)oxoacetyl, or alkylsulfonyl; or (R 11 )(R 11 )N taken together is selected from azetidinyl, bicyclo[1.1.1]pentanyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxidothiomorpholinyl, [3.1.1]diazabicycloheptanyl, [3.2.1]diazabicyclooctanyl, or tetrhydroquinolinyl and is substituted with 0-3 halo, alkyl, haloalkyl, benzyl, hydroxy, alkoxy, or haloalkoxy substituents and with 0-1 (C 3-7 )spiroalkylenyl substituents; Ar 1  is phenyl substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; and Ar 2  is selected from pyrazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, or pyridinyl and is substituted with 0-3 halo or alkyl substituents; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 88.0
- Lexical Diversity: 1.23333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15749133', '15749189', '15579977', '14770702', '16094536']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.805097194340086
- 35 USC 102 Novelty (BERT): 0.5849343515190777
- Combined Prediction Score: 0.7830809100579852
- Mean Citation Score: 433.226472
- Max Citation Score: 481.00058
- Similarity Product: 419.4817218327773

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test