PATENT CLAIM ANALYSIS

Application Number: 15956279
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["424", "494000"]

Abstract:
The presently disclosed subject matter provides a solid immediate release pharmaceutical particulate dosage form containing one population of particulates, and/or a solid immediate release pharmaceutical multi-particulate dosage form containing at least two different populations of particulates. In certain embodiments, the immediate release pharmaceutical dosage forms contain at least three different populations of multi-particulates. Each population of particulates is designed for a specific function to accomplish the desired combination of abuse deterrence and overdose protection.

Claim (Index 26):
A method of treating pain comprising administering to a patient in need thereof a food independent, multiparticulate dosage form that provides an immediate release of an opioid when a single dosage unit is consumed intact, independent of fed or fasted state of an individual consuming the dosage form, and provides overdose protection when multiple dosage units are consumed intact, the dosage form comprising:\n Active Particulates comprising a therapeutically effective amount of at least one opioid embedded in a polymer matrix, and an acid labile functional coat; and Triggering Particulates comprising an alkaline agent; wherein the acid labile functional coat comprises at least one functional coat layer FC 1 comprising at least one acid, a water-insoluble nonionic polymer, and a base polymer that is at least partially neutralized as a cationic salt at gastric fluid pH; wherein the alkaline agent is present in an amount sufficient, when three or more dosage units are consumed together, to increase gastric fluid pH to a level that reduces the solubility of the acid labile functional coat and causes a decrease in the immediate release of the opioid from the dosage form to provide the overdose protection; and wherein the acid is present in an amount that keeps the base polymer in partially neutralized form and maintains immediate release properties of the dosage form in the fed state.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 91.0
- Lexical Diversity: 1.54902
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15117114', '15271480', '14790101', '15271469', '15409170']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7411952913972542
- 35 USC 102 Novelty (BERT): 0.5108069548495906
- Combined Prediction Score: 0.7181564577424878
- Mean Citation Score: 270.449266
- Max Citation Score: 302.76727
- Similarity Product: 234.1326885837901

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test