PATENT CLAIM ANALYSIS

Application Number: 16163829
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["514", "210180"]

Abstract:
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Claim (Index 38):
The compound of  claim 1 , wherein R 3  and R 4  together with the nitrogen atom to which R 3  and R 4  are bound form a heterocycle, wherein the heterocycle is substituted by at least one substituent.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 97.0
- Lexical Diversity: 1.71739
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15436333', '14275667', '12538751', '14742481', '15346677']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7913592236890625
- 35 USC 102 Novelty (BERT): 0.6168783201766214
- Combined Prediction Score: 0.7739111333378185
- Mean Citation Score: 345.85709400000013
- Max Citation Score: 544.2079
- Similarity Product: 518.2195096147776

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test