PATENT CLAIM ANALYSIS

Application Number: 15770274
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["564", "304000"]

Abstract:
Disclosed is a process for preparing (Z)-endoxifen, comprising (i) recrystallizing an input crystalline solid comprising a mixture of (Z)-endoxifen (1) and (E)-endoxifen (2) from a first solvent to provide a first crystalline solid and a first mother liquor, wherein the first mother liquor has a ratio of (1) to (2) at least 1.3 times greater than the ratio in the input crystalline solid (1) and (2); (ii) recrystallizing a solid produced by concentrating the first mother liquor, or by removal of the first solvent from the first mother liquor, from a second solvent to give a second crystalline solid and a second mother liquor; (iii) optionally recrystallizing the second crystalline solid from the second solvent one to five additional times to give a third crystalline solid; wherein the third crystalline solid has a ratio of (Z)-endoxifen (1) to (E)-endoxifen (2) greater than 20:1.

Claim (Index 18):
The process of  claim 16 , further comprising\n (v) cooling the isomerized solution by 30 to 100\u00b0 C. to form a fourth crystalline solid and a fourth mother liquor, and removing the mother liquor followed by resubjecting the fourth crystalline solid to steps (iv) and (v) at least two times, and combining the resulting mother liquors to provide a combined mother liquor with a ratio of (Z)-endoxifen (1) to (E)-endoxifen (2) of at least 1.5 to 1.

Metadata:
- Claim Count in Document: 43.0
- Percentile: 91.0
- Lexical Diversity: 3.18644
- Patent Class: 564.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10482000', '12515261', '15139687', '14566091', '10455016']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7053853261427988
- 35 USC 102 Novelty (BERT): 0.5159811477512282
- Combined Prediction Score: 0.6864449083036417
- Mean Citation Score: 206.377506
- Max Citation Score: 221.58832
- Similarity Product: 150.36963877399447

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test