PATENT CLAIM ANALYSIS

Application Number: 15916828
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["536", "024330"]

Abstract:
Described herein are methods and kits for detecting the presence or absence of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g. translocations, insertions, inversions and deletions. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5′ portion of a target gene relative to the 3′ region of the target gene. The average expression of the 5′ portion of the target gene is compared with the average expression of the 3′ portion of the target gene to determine an intragenic differential expression (IDE). The IDE can then be used to determine if a dysregulation or a particular disease (or susceptibility to a disease) is present or absent in a subject or sample.

Claim (Index 44):
The kit of  claim 39 , wherein the two or more ROS1 3\u2032 target primer pairs comprises a primer pair having:\n a forward primer of SEQ ID NO: 31 and a reverse primer of SEQ ID NO: 32; \n a forward primer of SEQ ID NO: 33 and a reverse primer of SEQ ID NO: 34; \n a forward primer of SEQ ID NO: 35 and a reverse primer of SEQ ID NO: 36; \n a forward primer of SEQ ID NO: 37 and a reverse primer of SEQ ID NO: 38; and/or \n a forward primer of SEQ ID NO: 39 and a reverse primer of SEQ ID NO: 40.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.92958
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14667205', '15372752', '12786266', '13848974', '14454124']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.660688550814783
- 35 USC 102 Novelty (BERT): 0.5609148573733546
- Combined Prediction Score: 0.6507111814706401
- Mean Citation Score: 394.251238
- Max Citation Score: 511.31848
- Similarity Product: 293.3199807067872

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test