PATENT CLAIM ANALYSIS

Application Number: 15975462
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "303000"]

Abstract:
Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where R 1a , R 1b , R 1c , R 2 , R 3 , R 4  and R 5  are defined herein, pharmaceutical compositions comprising the compound and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, for example, for treating a disease or condition mediated by a JAK kinase in a patient.

Claim (Index 2):
A compound selected from the group consisting of: A [4-(4-chlorophenyl)-1-[2-[(1- methylpyrazol-4-yl)amino]- [1,2,4]triazolo[1,5-a]pyridin- 8-yl]-4-piperidyl]methanol   B 1-[4-(4-chlorophenyl)-1-[2- [(1-methylpyrazol-4-yl) amino]-[1,2,4]triazolo [1,5-a]pyridin- 8-yl]-4-piperidyl]-2- morpholino-ethanol   C 1-[4-(4-chlorophenyl)-1-[2-[(1- methylpyrazol-4-yl)amino]- [1,2,4]triazolo[1,5-a]pyridin-8- yl]-4-piperidyl]-2- (dimethylamino)ethanol   D 8-[4-(aminomethyl)-4-(4- chlorophenyl)-1-piperidyl]-N- (1-methylpyrazol-4-yl)- [1,2,4]triazolo[1,5-a]pyridin- 2-amine   E methyl 2-[2-[4-[2-[(1- methylpyrazol-4-yl) amino]-[1,2,4]triazolo [1,5-a]pyridin-8-yl]- 3,6-dihydro-2H- pyridine-1-carbonyl]- 2,7-diazaspiro[3.5] nonan-7-yl]acetate   F formic acid, methyl  2-[[4-(4-chlorophenyl)- 1-[2-[(1-methylpyrazol- 4-yl)amino]-[1,2,4]triazolo [1,5-a]pyridin-8-yl]-4- piperidyl]methylamino]   G 8-[4-(4-chlorophenyl)-4- [(2,2,2-trifluoroethylamino) methyl]-1-piperidyl]-N- (1-methylpyrazol-4-yl)- [1,2,4]triazolo[1,5-a] pyridin-2-amine   H 8-[4-(4-chlorophenyl)- 4-(2-morpholinoethyl)- 1-piperidyl]-N-(1- methylpyrazol-4-yl)- [1,2,4]triazolo[1,5-a] pyridin-2-amine   I N,N-dimethyl-2-[2-[4-[2-[(1- methylpyrazol-4-yl)amino]- [1,2,4]triazolo[1,5-a]pyridin- 8-yl]-3,6-dihydro-2H- pyridine-1-carbonyl]-2,7- diazaspiro[3.5]nonan-7- yl]acetamide   J [4-(4-methylsulfanylphenyl)- 1-[2-[[1-[2-(4-morpholino-1- piperidyl)ethyl]pyrazol- 4-yl]amino]-[1,2,4] triazolo[1,5-a]pyridin-8- yl]-4-piperidyl]methanol   K 2-[4-(4-methylsulfanylphenyl)- 1-[2-[[1-[2-(4-morpholino-1- piperidyl)ethyl]pyrazol-4- yl]amino]-[1,2,4]triazolo [1,5-a]pyridin-8-yl]-4- piperidyl]acetonitrile   L 2-[1[2-[[1-[2-(4- acetylpiperazin-1-yl)ethyl] pyrazol-4-yl]amino]- [1,2,4]triazolo[1,5-a]pyridin- 8-yl]-4-(4- methylsulfanylphenyl)-4- piperidyl]acetonitrile   M 2-[4-(4-methylsulfanylphenyl)- 1-[2-[[1-[2-(4-tetrahydropyran- 4-ylpiperazin-1-yl)ethyl] pyrazol-4-yl]amino]- [1,2,4]triazolo[1,5- a]pyridin-8-yl]-4- piperidyl]acetonitrile   N 2-[1-[2-[[1-[2- (dimethylamino)ethyl] pyrazol-4-yl]amino]- [1,2,4]triazolo[1,5-a] pyridin-8-yl]-4-(4- methylsulfanylphenyl)-4- piperidyl]acetonitrile   O 2-[l-[2-[[1-[2-(4-methyl- 3-oxo-piperazin-1-yl) ethyl]pyrazol-4-yl] amino]-[1,2,4]triazolo [1,5-a]pyridin-8-yl]-4- (4-methylsulfanylphenyl)- 4-piperidyl]acetonitrile   P 2-[4-(4-methylsulfanylphenyl)- 1-[2-[[1-[2-(oxetan-3- ylamino)ethyl]pyrazol- 4-yl]amino]-[1,2,4] triazolo[1,5-a]pyridin-8- yl]-4-piperidyl]acetonitrile   Q 4-[2-[4-[[8-[4-(cyanomethyl)- 4-(4-methylsulfanylphenyl)-1- piperidyl]-[1,2,4]triazolo [1,5-a]pyridin-2- yl]amino]pyrazol-1-yl]ethyl]- N,N-dimethyl-piperazine- 1-carboxamide   R and [1-[2-[[1-(2-aminoethyl) pyrazol-4-yl]amino]-[1,2,4] triazolo[1,5-a]pyridin-8- yl]-4-(4- methylsulfanylphenyl)-4- piperidyl]methanol   S 2-[3-(4-ethylpyrazol-1-yl)- 1-[2-[[1-[[1-[1-(oxetan-3-yl)- 4-piperidyl]triazol-4-yl] methyl]pyrazol-4-yl]amino]- [1,2,4]triazolo[1,5-a] pyridin-8-yl]azetidin-3- yl]acetonitrile or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 93.0
- Lexical Diversity: 1.83582
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15499662', '14049458', '13471269', '13004808', '14720323']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8037345431396242
- 35 USC 102 Novelty (BERT): 0.5745210221633168
- Combined Prediction Score: 0.7808131910419935
- Mean Citation Score: 386.797376
- Max Citation Score: 452.7919
- Similarity Product: 414.36313627313376

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test