PATENT CLAIM ANALYSIS

Application Number: 16298308
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["800", "006000"]

Abstract:
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided.

Claim (Index 45):
The method of  claim 21 , wherein the human V\u03bb gene segment from which the rearranged human lambda light chain variable region is derived is a human V\u03bb3-1, V\u03bb4-3, V\u03bb2-8, V\u03bb3-9, V\u03bb3-10, V\u03bb2-14, V\u03bb3-19, V\u03bb2-23, V\u03bb3-25, V\u03bb1-40, V\u03bb7-43, V\u03bb1-44, V\u03bb5-45, V\u03bb7-46, V\u03bb9-49, V\u03bb1-51, V\u03bb1-47, or V\u03bb7-46.

Metadata:
- Claim Count in Document: 85.0
- Percentile: 99.0
- Lexical Diversity: 2.13725
- Patent Class: 800.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14636784', '13945573', '13166171', '14638429', '14943890']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8693393993184582
- 35 USC 102 Novelty (BERT): 0.6991937696260478
- Combined Prediction Score: 0.8523248363492171
- Mean Citation Score: 1051.25974
- Max Citation Score: 1062.2339
- Similarity Product: 748.5098761338472

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test