PATENT CLAIM ANALYSIS

Application Number: 15741846
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["544", "385000"]

Abstract:
The invention relates to a process for preparing 2,6-bis(methionyl)-1,4-dketopiperazine, comprising the following steps: a) heating a reaction mixture comprising methionine and polar protic solvent at a temperature of less than 170.0° C., while passing an inert gas stream over or through the reaction mixture; b) obtaining 2,6-bis(methionyl)-1,4-diketopiperazine.   The invention further relates to a process for isolating 2,6-bis(methionyl)-1,4-diketopiperazine from a reaction mixture, comprising the following steps:  A1) diluting the reaction mixture comprising 2,6-bis(methionyl)-1,4-diketopiperazine with a polar solvent and water, with crystallization of 2,6-bis(methionyl)-1,4-diketopiperazine; or A2) diluting the reaction mixture comprising 2,6-bis(methionyl-1,4-diketopiperazine only with water without prior dilution with an organic solvent with or without pressure retention, with crystallization of 2,6-bis(mehionyl)-1,4-diketopiperazine; or A3) cooling the reaction mixture down or allowing it to cool down without addition of substances until a temperature, especially of 135.0° C. to less than 145.0° C., preferably of 138.0° C. to 142.0° C., is reached, at which the diketopiperazine starts to crystallize, and finally diluting it and hence cooling it by addition of water, with crystallization of 2,6-bis(methionyl)-1,4-dketopiperazine; B) removing the crystalized 2,6-bis(methionyl)-1,4-dketopiperazine obtained in A1) or A2) or A3) in solid form and washing it with a solvent, especially ethylene glycol, acetone or methanol, and finally washing with water.   More particularly, the present invention relates to a combination of a process for preparing 2,6-bis(methionyl)-1,4-diketopiperazine and a process for isolating 2,6-bis(methionyl)-1,4-diketopiperazine from a reaction mixture.

Claim (Index 11):
The process according to  claim 1 , wherein the inert gas stream is passed through the reaction mixture, in order to remove the water formed in the reaction from the reaction mixture, where the inert gas on introduction into the reaction mixture has a temperature of at least 100.0\u00b0 C.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 86.0
- Lexical Diversity: 2.84906
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13616341', '14415687', '14543464', '13368172', '14415690']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7259536726165897
- 35 USC 102 Novelty (BERT): 0.5173617632382537
- Combined Prediction Score: 0.7050944816787561
- Mean Citation Score: 182.26898
- Max Citation Score: 203.98398
- Similarity Product: 108.56644630081416

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test