PATENT CLAIM ANALYSIS

Application Number: 15772938
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["435", "007100"]

Abstract:
The level of exosomal polypeptides in a sample from a patient who has received a transplant is assayed and used as an indicator for transplant rejection. Based on the measured level of the exosomal polypeptides, therapeutic intervention, such as an immunosuppressant therapy, may be started, adjusted, continued or discontinued.

Claim (Index 1):
A method for detecting transplant rejection in a subject who has received a transplant or assessing the subject's risk of transplant rejection, the method comprising the steps of:\n S (a) obtaining a sample from the subject; (b) isolating exosomes from the sample; (c) determining level of one or more exosomal polypeptides in the exosomes; (d) comparing the level obtained in step (c) with the level of the one or more exosomal polypeptide in a control sample; and (e) diagnosing that the subject has transplant rejection or an increased risk of transplant rejection, if the level of at least one exosomal polypeptide obtained in step (c) increases or decreases by at least 10% compared to its level in the control sample.

Metadata:
- Claim Count in Document: 58.0
- Percentile: 93.0
- Lexical Diversity: 1.36585
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14591542', '13009393', '13009285', '13635667', '14170132']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5532860165066664
- 35 USC 102 Novelty (BERT): 0.5026169707799506
- Combined Prediction Score: 0.5482191119339949
- Mean Citation Score: 247.684926
- Max Citation Score: 253.45285
- Similarity Product: 186.84118636630177

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test