PATENT CLAIM ANALYSIS

Application Number: 15932251
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "136100"]

Abstract:
Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.

Claim (Index 72):
The multispecific binding molecule of  claim 1  or  claim 2 , comprising:\n (a) a first antibody heavy chain comprising a first heavy chain variable (VH) domain and a first Fc region of an immunoglobulin comprising a first C H3  region, and a first antibody light chain comprising a first light chain variable (VL) domain, wherein the first VH and VL domains form a first antigen binding domain that binds an extracellular portion of dystroglycan, and \n (b) a second antibody heavy chain comprising a second heavy chain variable (VH) domain and a second Fc region of an immunoglobulin comprising a second C H3  region, and a second antibody light chain comprising a second light chain variable (VL) domain, wherein the second VH and VL domains form a second antigen binding domain that binds laminin-2; \n wherein the sequences of said first and second C H3  regions are different and are such that the heterodimeric interaction between said first and second C H3  regions is stronger than each of the homodimeric interactions of said first and second C H3  regions, and wherein said first homodimeric protein has an amino acid other than Lys, Leu or Met at position 409 and said second homodimeric protein has an amino-acid substitution at a position selected from the group consisting of: 366, 368, 370, 399, 405 and 407 and/or wherein the sequences of said first and second C H3  regions are such that the dissociation constants of homodimeric interactions of each of the C H3  regions are between 0.01 and 10 micromolar.

Metadata:
- Claim Count in Document: 40.0
- Percentile: 88.0
- Lexical Diversity: 1.43243
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14400642', '14075755', '14539845', '14358520', '15315371']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7554800414325478
- 35 USC 102 Novelty (BERT): 0.5675358776413895
- Combined Prediction Score: 0.7366856250534319
- Mean Citation Score: 462.67613
- Max Citation Score: 468.49353
- Similarity Product: 351.28888752383347

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test