PATENT CLAIM ANALYSIS

Application Number: 16179177
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["435", "007100"]

Abstract:
A multiphoton fluorescence anisotropy microscopy live cell imaging system and method to measure and map drug-target interaction in real time at subcellular resolution. Proposed modality enables a direct measurement of drug/target binding in vivo, high-resolution spatial and temporal mapping of bound and unbound drug distribution, and presents an versatile tool to enhance understanding of drug activity. Application of the system to measurement of intracellular target engagement of the chemotherapeutic Olaparib, a poly(ADP-ribose) polymerase inhibitor, in live cells and within a tumor in vivo.

Claim (Index 1):
A system for spatially-resolving a portion of a target containing fluorescently-labeled target-bound molecules, of the fluorescently labeled molecules with the system comprising:\n a source of light configured to generate light to be absorbed by the target via a multi-photon process; an optical system positioned to optically relay light generated by the source of light onto an object plane of said system and form first and second images of said object plane, at first and second image planes respectively, in light emitted from the object plane\n wherein said first image is formed in light emitted from the object plane and having only a first state of polarization; \n wherein said second image is formed in light emitted from the object plane and having only a second state of polarization; \n and\n a processor programmed to transform said first and second images into a third image representing spatial anisotropy of said target.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 98.0
- Lexical Diversity: 1.43077
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11173814', '13369902', '13504112', '15581386', '16147370']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5414443006657302
- 35 USC 102 Novelty (BERT): 0.4883969298281689
- Combined Prediction Score: 0.5361395635819741
- Mean Citation Score: 198.94689
- Max Citation Score: 219.01436
- Similarity Product: 169.67145290921212

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test