PATENT CLAIM ANALYSIS

Application Number: 15946066
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "466000"]

Abstract:
Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, The method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of PCSK9, and to stimulate secretion of glucagon-like peptide 1 in mammals.

Claim (Index 5):
The method of  claim 1 , wherein the method proceeds by a reaction pathway as follows: wherein each R 1  is independently hydrogen or alkyl; \u201cPG\u201d designates an amine protecting group; and each R, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 4 \u2032, R 5 \u2032, R 6 \u2032, and R 7 \u2032 is independently selected from hydrogen, halogen, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heterocyclylallkyl.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 91.0
- Lexical Diversity: 1.66129
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14818960', '14239541', '14111991', '14977011', '15541875']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7796182295212675
- 35 USC 102 Novelty (BERT): 0.6019891197825252
- Combined Prediction Score: 0.7618553185473933
- Mean Citation Score: 344.059252
- Max Citation Score: 563.0151
- Similarity Product: 449.6350774852573

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test