PATENT CLAIM ANALYSIS

Application Number: 15914566
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["435", "320100"]

Abstract:
An expression vector containing appropriate mitochondrion-targeting sequences (MTS) and appropriate 3′UTR sequences provides efficient and stable delivery of a mRNA encoding a protein (CDS) to the mitochondrion of a mammalian cell. The MTS and 3′UTR sequences guide the CDS mRNA from the nuclear compartment of the cell to mitochondrion-bound polysomes, where the CDS is translated. This provides an efficient translocation of a mature functional protein into the mitochondria. A method of targeting mRNA expressed in the nuclear compartment of a mammalian cell to the mitochondrion is also provided. The vector and methods can be used to treat defects in mitochondrial function.

Claim (Index 1):
An expression vector configured for the efficient and stable delivery of a protein into the mitochondrion of a mammalian cell, the vector comprising:\n a mitochondrion-targeting nucleic acid sequence (MTS); a nucleic acid sequence encoding said protein in accordance with a universal genetic code (CDS); and a 3\u2032UTR nucleic acid sequence, located 3\u2032 of said CDS, configured to target mRNA expressed by the expression vector in the nucleus to the mitochondrion-bound polysomes of the mammalian cell, wherein, said MTS consists of a nucleic acid sequence encoding the peptide SEQ ID NO: 46, and said 3\u2032UTR nucleic acid sequence consists of a conservative variant or fragment of the nucleic acid sequence SEQ ID NO: 47, said conservative variant or fragment still allowing for the mitochondrial targeting of the mRNA.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.81967
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11913618', '10687677', '12526878', '13860156', '12143886']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5863581122368838
- 35 USC 102 Novelty (BERT): 0.7221802907218694
- Combined Prediction Score: 0.5999403300853825
- Mean Citation Score: 459.9062980000001
- Max Citation Score: 832.8029
- Similarity Product: 763.0277521091583

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test