PATENT CLAIM ANALYSIS

Application Number: 15998789
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-05
Patent Classification: ["514", "267000"]

Abstract:
The present disclosure provides for compounds of formula (I) wherein A 2 , A 3 , A 4 , A 6 , A 7 , A 8 , R 15 , R A , R 5 , R 9 , R 10A , R 10B , R 11 , R 12 , R 13 , R 14 , R 16 , W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

Claim (Index 1):
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein\n A 2  is CR 2 , A 3  is N, A 4  is CR 4a , and A 6  is C; or \n A 2  is CR 2 , A 3  is N, A 4  is O or S, and A 6  is C; or \n A 2  is CR 2 , A 3  is C, A 4  is O or S and A 6  is C; or \n A 2  is N, A 3  is C, A 4  is O or S and A 6  is C; or \n A 2  is N, A 3  is C, A 4  is CR 4a , and A 6  is N; \n R A  is hydrogen, CH 3 , halogen, CN, CH 2 F, CHF 2 , or CF 3 ; \n X is O, or N(R x2 ); wherein R x2  is hydrogen, C 1 -C 3  alkyl, or unsubstituted cyclopropyl; \n Y is (CH 2 ) m , \u2014CH\u2550CH\u2014(CH 2 ) n \u2014, \u2014(CH 2 ) p \u2014CH\u2550CH\u2014, or \u2014(CH 2 ) q \u2014CH\u2550CH\u2014(CH 2 ) r ; wherein 0, 1, 2, or 3 CH 2  groups are each independently replaced by O, N(R ya ), C(R ya )(R yb ), C(O), NC(O)R ya , or S(O) 2 ; \n m is 2, 3, 4, or 5; \n n is 1, 2, or 3; \n p is 1, 2, or 3; \n q is 1 or 2; and \n r is 1 or 2; wherein the sum of q and r is 2 or 3; \n R ya , at each occurrence, is independently hydrogen, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, G 1 , C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; wherein the C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl are optionally substituted with 1 or 2 substituents independently selected from the group consisting of oxo, \u2014N(R yd )(R ye ), G 1 , \u2014OR yf , \u2014SR yg , \u2014S(O) 2 N(R yd )(R ye ), and \u2014S(O) 2 -G 1 ; and \n R yb  is C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, G 1 , C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; wherein the C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl are optionally substituted with 1 or 2 substituents independently selected from the group consisting of oxo, \u2014N(R yd )(R ye ), G 1 , \u2014OR yf , \u2014SR yg , \u2014S(O) 2 N(R yd )(R ye ), and \u2014S(O) 2 -G 1 ; or \n R ya  and R yb , together with the carbon atom to which they are attached, form a C 3 -C 7  monocyclic cycloalkyl, C 4 -C 7  monocyclic cycloalkenyl, or a 4-7 membered monocyclic heterocycle; wherein the C 3 -C 7  monocyclic cycloalkyl, C 4 -C 7  monocyclic cycloalkenyl, and the 4-7 membered monocyclic heterocycle are each optionally substituted with 1 \u2014OR m  and 0, 1, 2, or 3 independently selected R s  groups; \n R yd , R ye , R yf , and R yg , at each occurrence, are each independently hydrogen, G 1 , C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; wherein the C 1 -C 6  alkyl and the C 1 -C 6  haloalkyl are optionally substituted with one substituent selected from the group consisting of G 1 , \u2014OR yh , \u2014SR yh , \u2014SO 2 R yh , and \u2014N(R yi )(R yk ); \n G 1 , at each occurrence, is piperazinyl, piperidinyl, pyrrolidinyl, thiomorpholinyl, tetrahydropyranyl, morpholinyl, oxetanyl, 1,3-dioxolanyl, 1,3-dioxanyl, 1,4-dioxanyl, 1,3-dioxepanyl, or 1,4-dioxepanyl; wherein each G 1  is optionally substituted with 1 \u2014OR m  and 0, 1, 2, or 3 substituents independently selected from the group consisting of G 2 , \u2014(C 1 -C 6  alkylenyl)-G 2 , and R s ; \n G 2 , at each occurrence, is a C 3 -C 7  monocyclic cycloalkyl, C 4 -C 7  monocyclic cycloalkenyl, oxetanyl, morpholinyl, 1,3-dioxolanyl, 1,3-dioxanyl, 1,4-dioxanyl, 1,3-dioxepanyl, or 1,4-dioxepanyl; wherein each G 2  is optionally substituted with 1 \u2014OR m  and 0, 1, or 2 independently selected R t  groups; \n R 2  is independently hydrogen, halogen, CH 3 , or CN; \n R 4a , at each occurrence, is independently hydrogen, halogen, CN, C 2 -C 4  alkenyl, C 2 -C 4  alkynyl, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, G A , C 1 -C 4  alkyl-G A , or C 1 -C 4  alkyl-O-G A ; wherein each G A  is independently C 6 -C 10  aryl, C 3 -C 7  monocyclic cycloalkyl, C 4 -C 7  monocyclic cycloalkenyl, or 4-7 membered heterocycle; wherein each G A  is optionally substituted with 1, 2, or 3 R u  groups; \n R 5  is independently hydrogen, halogen, G 3 , C 1 -C 6  alkyl, C 2 -C 6  alkenyl, or C 2 -C 6  alkynyl; wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each optionally substituted with one G 3 ; \n G 3 , at each occurrence, is independently C 6 -C 10  aryl, 5-11 membered heteroaryl, C 3 -C 11  cycloalkyl, C 4 -C 11  cycloalkenyl, oxetanyl, 2-oxaspiro[3.3]heptanyl, 1,3-dioxolanyl, 1,3-dioxanyl, 1,4-dioxanyl, 1,3-dioxepanyl, 2,3-dihydro-1,4-dioxinyl, or 1,4-dioxepanyl; wherein each G 3  is optionally substituted with 1, 2, or 3 R v  groups; \n A 7  is N or CR 7 ; \n A 8  is N or CR 8 ; \n A 15  is N or CR 15 ; \n R 7 , R 12  and R 16  are each independently hydrogen, halogen, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, \u2014CN, \u2014OR 7a , \u2014SR 7a , or \u2014N(R 7b )(R 7c ); \n R 8 , R 13 , R 14 , and R 15  are each independently hydrogen, halogen, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, \u2014CN, \u2014OR 8a , \u2014SR 8a , \u2014N(R 8b )(R 8c ), or C 3 -C 4  monocyclic cycloalkyl; wherein the C 3 -C 4  monocyclic cycloalkyl is optionally substituted with one or two substituents independently selected from the group consisting of halogen, C 1 -C 3  alkyl, and C 1 -C 3  haloalkyl; or \n R 8  and R 13  are each independently hydrogen, halogen, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, \u2014CN, \u2014OR 8a , \u2014SR 8a , \u2014N(R 8b )(R 8c ), or C 3 -C 4  monocyclic cycloalkyl; wherein the C 3 -C 4  monocyclic cycloalkyl is optionally substituted with one or two substituents independently selected from the group consisting of halogen, C 1 -C 3  alkyl, and C 1 -C 3  haloalkyl; and \n R 14  and R 15 , together with the carbon atoms to which they are attached, form a monocyclic ring selected from the group consisting of benzene, cyclobutane, cyclopentane, and pyridine; wherein the monocyclic ring is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, \u2014CN, \u2014OR 8a , \u2014SR 8a , and \u2014N(R 8b )(R 8c ); \n R 9  is \u2014OH, \u2014O\u2014C 1 -C 4  alkyl, \u2014O\u2014CH 2 \u2014OC(O)(C 1 -C 6  alkyl), \u2014NHOH, \n or \u2014N(H)S(O) 2 \u2014(C 1 -C 6  alkyl);\n R 10A  and R 10B , are each independently hydrogen, C 1 -C 3  alkyl, or C 1 -C 3  haloalkyl; or R 10A  and R 10B , together with the carbon atom to which they are attached, form a cyclopropyl; wherein the cyclopropyl is optionally substituted with one or two substituents independently selected from the group consisting of halogen and CH 3 ; \n W is \u2014CH\u2550CH\u2014, C 1 -C 4  alkyl, \u2014O\u2014CHF\u2014, -L 1 -CH 2 \u2014, or \u2014CH 2 -L 1 -; wherein L 1  at each occurrence, is independently O, S, S(O), S(O) 2 , S(O) 2 N(H), N(H), or N(C 1 -C 3  alkyl); \n R 11  is a C 6 -C 10  aryl or a 5-11 membered heteroaryl; wherein each R 11  is optionally substituted with 1, 2, or 3 independently selected R W  groups; \n R W , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, \u2014CN, NO 2 , \u2014OR 11a , \u2014SR 11b , \u2014S(O) 2 R 11b , \u2014S(O) 2 N(R 11c ) 2 , \u2014C(O)R 11a , \u2014C(O)N(R 11c ) 2 , \u2014N(R 11c ) 2 , \u2014N(R 11c )C(O)R 11b , \u2014N(R 11c )S(O) 2 R 11b , \u2014N(R 11c )C(O)O(R 11b ), \u2014N(R 11c )C(O)N(R 11c ) 2 , G 4 , \u2014(C 1 -C 6  alkylenyl)-OR 11a , \u2014(C 1 -C 6  alkylenyl)-OC(O)N(R 11c ) 2 , \u2014(C 1 -C 6  alkylenyl)-SR 11a , \u2014(C 1 -C 6  alkylenyl)-S(O) 2 R 11b , \u2014(C 1 -C 6  alkylenyl)-S(O) 2 N(R 11c ) 2 , \u2014(C 1 -C 6  alkylenyl)-C(O)R 11a , \u2014(C 1 -C 6  alkylenyl)-C(O)N(R 11c ) 2 , \u2014(C 1 -C 6  alkylenyl)-N(R 11c ) 2 , \u2014(C 1 -C 6  alkylenyl)-N(R 11c )C(O)R 11b , \u2014(C 1 -C 6  alkylenyl)-N(R 11c )S(O) 2 R 11b , \u2014(C 1 -C 6  alkylenyl)-N(R 11c )C(O)O(R 11b ), \u2014(C 1 -C 6  alkylenyl)-N(R 11c )C(O)N(R 11c ) 2 , \u2014(C 1 -C 6  alkylenyl)-CN, or \u2014(C 1 -C 6  alkylenyl)-G 4 ; \n R 11a  and R 11c , at each occurrence, are each independently hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 1 -C 6  haloalkyl, G 4 , \u2014(C 2 -C 6  alkylenyl)-OR 11d , \u2014(C 2 -C 6  alkylenyl)-N(R 11e ) 2 , or \u2014(C 2 -C 6  alkylenyl)-G 4 ; \n R 11b , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 1 -C 6  haloalkyl, G 4 , \u2014(C 2 -C 6  alkylenyl)-OR 11d , \u2014(C 2 -C 6  alkylenyl)-N(R 11e ) 2 , or \u2014(C 2 -C 6  alkylenyl)-G 4 ; \n G 4 , at each occurrence, is independently phenyl, monocyclic heteroaryl, C 3 -C 11  cycloalkyl, C 4 -C 11  cycloalkenyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, 2,6-dioxa-9-azaspiro[4.5]decanyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 3-oxa-8-azabicyclo[3.2.1]octanyl, piperidinyl, piperazinyl, azetidinyl, morpholinyl, dihydropyranyl, tetrahydropyridinyl, dihydropyrrolyl, pyrrolidinyl, 2,3-dihydrodioxinyl, 1,3-dioxolanyl, 1,3-dioxanyl, 1,4-dioxanyl, 1,3-dioxepanyl, or 1,4-dioxepanyl; wherein each G 4  is optionally substituted with 1 \u2014OR m  and 0, 1, 2, or 3 substituents independently selected from the group consisting of G 5 , R y , \u2014(C 1 -C 6  alkylenyl)-G 5 , \u2014(C 1 -C 6  alkylenyl)-L 2 -(C 1 -C 6  alkylenyl)-G 5 , and -L 2 -(C 1 -C 6  alkylenyl) s -G 5 ; \n L 2  is O, C(O), N(H), N(C 1 -C 6  alkyl), NHC(O), C(O)O, S, S(O), or S(O) 2 ; \n s is 0 or 1; \n G 5 , at each occurrence, is independently phenyl, monocyclic heteroaryl, C 3 -C 7  monocyclic cycloalkyl, C 4 -C 7  monocyclic cycloalkenyl, piperazine, 1,3-dioxolanyl, 1,3-dioxanyl, 1,4-dioxanyl, 1,3-dioxepanyl, or 1,4-dioxepanyl; wherein each G 5  is optionally substituted with 1 independently selected \u2014OR m  or 0, 1, 2, or 3 R z  groups; \n R s , R t , R u , R v , R y , and R z , at each occurrence, are each independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alanyl, halogen, C 1 -C 6  haloalkyl, \u2014CN, oxo, NO 2 , P(O)(R k ) 2 , \u2014OC(O)R k , \u2014OC(O)N(R j ) 2 , \u2014SR j , \u2014S(O) 2 R k , \u2014S(O) 2 N(R j ) 2 , \u2014C(O)R j , \u2014C(O)N(R j ) 2 , \u2014N(R j ) 2 , \u2014N(R j )C(O)R k , \u2014N(R j )S(O) 2 R k , \u2014N(R j )C(O)C)(R k ), \u2014N(R j )C(O)N(R j ) 2 , \u2014(C 1 -C 6  alkylenyl)-OR j , (C 1 -C 6  alkylenyl)-OC(O)N(R j ) 2 , \u2014(C 1 -C 6  alkylenyl)-SR j , \u2014(C 1 -C 6  alkylenyl)-S(O) 2 R k , \u2014(C 1 -C 6  alkylenyl)-S(O) 2 N(R j ) 2 , \u2014(C 1 -C 6  alkylenyl)-C(O)R j , \u2014(C 1 -C 6  alkylenyl)-C(O)N(R j ) 2 , \u2014(C 1 -C 6  alkylenyl)-N(R j ) 2 , \u2014(C 1 -C 6  alkylenyl)-N(R j )C(O)R k , \u2014(C 1 -C 6  alkylenyl)-N(R j )S(O) 2 R k , \u2014(C 1 -C 6  alkylenyl)-N(R j )C(O)O(R k ), \u2014(C 1 -C 6  alkylenyl)-N(R j )C(O)N(R j ) 2 , or \u2014(C 1 -C 6  alkylenyl)-CN; \n R m  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, \u2014(C 2 -C 6  alkylenyl)-OR j , or \u2014(C 2 -C 6  alkylenyl)-N(R j ) 2 ; \n R yh , R yi , R yk , R 7a , R 7b , R 7c , R 8a , R 8b , R 8c , R 11d , R 11e , and R j , at occurrence, are each independently hydrogen, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; and \n R k , at each occurrence, is independently C 1 -C 6  alkyl or C 1 -C 6  haloalkyl; \n wherein at least one of G 1 , G 2 , G 3 , G 4 , and G 5  is 2,2-dimethyl-1,3-dioxolanyl, 2,3-dihydro-1,4-dioxinyl, 1,3-dioxolanyl, 1,3-dioxanyl, 1,4-dioxanyl, 1,3-dioxepanyl, or 1,4-dioxepanyl.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 96.0
- Lexical Diversity: 1.83871
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13828285', '13428259', '15496094', '14392200', '15287911']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7898666356940687
- 35 USC 102 Novelty (BERT): 0.5167018990470945
- Combined Prediction Score: 0.7625501620293713
- Mean Citation Score: 290.927282
- Max Citation Score: 302.1830700000001
- Similarity Product: 238.9145451935024

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test