PATENT CLAIM ANALYSIS

Application Number: 16071967
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["562", "466000"]

Abstract:
The invention relates to improved method of synthesis for Treprostinil comprising condensation reaction of the carbonyl compound having allyl, alkyl, crotyl or MEM-protected phenolic hydroxyl group, compound (4) with a hydroxyl-protected alkynol (5) to give the condensation product, compound (6). Subjecting compound (6) to oxidation, reduction, hydroxyl protection and carbonylation, cyclization reactions gave the tricyclic derivative (10). Further reactions comprising reduction, hydrogenation and deprotection of the phenolic and side-chain hydroxyl groups, wherein the sequence and choice of reagents was governed by protecting groups, gave the triol intermediate, compound (14). Cyanoalkylation at phenolic hydroxyl functionality and further hydrolysis yielded the prostacyclin compound, Treprostinil (1) and its pharmaceutically acceptable salts, having desired purity.

Claim (Index 20):
The process as claimed in  claim 12  wherein compound (4) is obtained by treating meta hydroxy benzaldehyde with allyl bromide in presence of a base to provide compound (2), which on rearrangement gave compound (3) and subsequent protection of hydroxyl group gave compound (4), wherein R is unsaturated alkyl, alkyl, alkoxyalkyl, substituted or unsubstituted arylalkyl.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 95.0
- Lexical Diversity: 1.775
- Patent Class: 562.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['11319287', '13824210', '14223034', '10583833', '13435708']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7290492276337482
- 35 USC 102 Novelty (BERT): 0.497329299315053
- Combined Prediction Score: 0.7058772348018788
- Mean Citation Score: 228.112676
- Max Citation Score: 231.08937000000003
- Similarity Product: 173.23132567318083

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test