PATENT CLAIM ANALYSIS

Application Number: 15761725
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["514", "017800"]

Abstract:
The present invention relates to an agent which inhibits Kallikrein-8 for use in the treatment or prevention of Alzheimer's disease and/or its precursor stages, as well as to methods, kits and uses relating thereto, including diagnostic tools.

Claim (Index 5):
An agent for use according to any of  claims 1  to  4 ,\n (a) wherein the agent is bound to a compound which is able to transport the agent across the blood-brain barrier,\n preferably wherein the agent is bound to the compound covalently or non-covalently, and/or in from of a fusion protein, conjugate, complex, liposome or nanoparticle, \n more preferably wherein the agent is bound to an antibody which specifically binds to the Transferrin receptor (Tfr) or a functionally active part thereof or an antibody mimetic thereof, \n \n and/or \n (b) wherein the agent is administered intravenously, nasally, orally, by implantation into the brain or by intraventricular delivery, \n and/or \n (c) wherein the patient exhibits an increased level of Kallikrein-8 and/or kallikrein-8 mRNA in brain tissue and/or in cerebrospinal fluid and/or in the blood, \n and/or \n (d) wherein the disease symptoms increased anxiety and/or cognitive impairment are prevented or treated.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 90.0
- Lexical Diversity: 1.10526
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12157664', '13393220', '14324289', '13701758', '11185907']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7778455090229605
- 35 USC 102 Novelty (BERT): 0.5245068703094403
- Combined Prediction Score: 0.7525116451516084
- Mean Citation Score: 308.592442
- Max Citation Score: 328.3323
- Similarity Product: 234.18521829382183

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test