PATENT CLAIM ANALYSIS

Application Number: 15753552
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA. The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.

Claim (Index 44):
A method according to  claim 43 , wherein E, E\u2032 or E\u2033 has independently the structure as set forth in Formula (IXa), Formula (IXb), Formula (IXc), Formula (IXd), Formula (Xe), Formula (IXf), Formula (IXg), and Formula (IXh): including pharmaceutically-acceptable salts, hydrates, solvates, and metal chelates, and solvates and hydrates of the salts: wherein L 3  is as defined in Formula (I); W and G are each independently selected from null, oxygen, ester, amide or secondary or tertiary amine groups; a, b, k and d, each stands independently for an integer, selected from 0, 1, 2, 3, 4, 5 or 6; R\u2032\u2033 is selected from the group consisting of hydrogen, methyl and ethyl; and the E, E\u2032 or E\u2033 moiety is conjugated to D; wherein D is a drug, as defined in Formula (I); including pharmaceutically-acceptable salts, hydrates, solvates, and metal chelates, and solvates and hydrates of the respective salts.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 88.0
- Lexical Diversity: 1.66102
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15222559', '14872179', '14830799', '15691821', '14690499']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8441947606404665
- 35 USC 102 Novelty (BERT): 0.605396366718148
- Combined Prediction Score: 0.8203149212482347
- Mean Citation Score: 441.934864
- Max Citation Score: 574.69934
- Similarity Product: 475.36001688528063

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test