PATENT CLAIM ANALYSIS

Application Number: 16076479
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["424", "136100"]

Abstract:
The present invention relates to engineered cells, engineered chimaeric antigen ligands (CALs), novel uses of multi-specific binding agents for bridging cells, and methods of therapy. The invention also provides variation-matched engineered cells.

Claim (Index 100):
The method of  claim 99 , wherein the germline genome of the human comprises\n D. an endogenous nucleotide sequence encoding a human CD3-zeta or CD3-eta intracellular domain comprising SEQ ID NO: 10 or with up to 10, 9, 8, 7, 6 or five amino acid differences (but wherein the tyrosines are conserved), when the first signaling domain comprises motif (a) according to claim  99 A; E. an endogenous nucleotide sequence encoding a human CD3-zeta or CD3-eta intracellular domain comprising SEQ ID NO: 11 or with up to 10, 9, 8, 7, 6 or five amino acid differences wherein the tyrosines are conserved, when the first signaling domain comprises motif (b) according to claim  99 A; F. an endogenous nucleotide sequence encoding a human CD3-zeta or CD3-eta intracellular domain comprising SEQ ID NO: 12 or with up to 10, 9, 8, 7, 6 or five amino acid differences wherein the tyrosines are conserved, when the first signaling domain comprises motif (c) according to claim  99 A; G. an endogenous nucleotide sequence encoding a human CD28 intracellular domain comprising at least 13 amino acid residues selected from the group consisting of R180, S181, K182, R183, S184, R185, L186, D190, Y191, N193, P196, P199, T202, K204, Q207, F215, A217 and Y218 (position numbers correspond to positions of SEQ ID NO: 13), when the first signaling domain is according to claim  99 B(d); H. an endogenous nucleotide sequence encoding a human CD28 intracellular domain comprising a YMNM motif (corresponding to Y191-M192-N193-M194 of SEQ ID NO: 13), when the first signaling domain is according to claim  99 C(e): or I. an endogenous nucleotide sequence encoding a human CD28 intracellular domain comprising a PYAP motif (corresponding to P208-Y209-A210-P211 of SEQ ID NO: 13), when the first signaling domain is according to claim  99 C(f).

Metadata:
- Claim Count in Document: 53.0
- Percentile: 96.0
- Lexical Diversity: 1.34483
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15866222', '15934770', '15105074', '15637734', '15106783']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7388296834246955
- 35 USC 102 Novelty (BERT): 0.5216881359413169
- Combined Prediction Score: 0.7171155286763576
- Mean Citation Score: 319.32395
- Max Citation Score: 322.89294
- Similarity Product: 208.997111849624

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test