PATENT CLAIM ANALYSIS

Application Number: 15884745
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-08
Patent Classification: ["424", "469000"]

Abstract:
This invention relates to abuse-deterrent pharmaceutical compositions and dosage forms and manufacturing processes thereof, the compositions comprising an agonist and antagonist that are difficult to separate visually, physically, or chemically. The compositions comprise a tacky amorphous polymer and a crystalline polymer curing agent for the amorphous polymer such that the agonist is releasable and the antagonist is non-releasable unless the dosage forms are tampered with. The non-extractable dosage forms reduce the potential for prescription drug abuse.

Claim (Index 1):
A non-extractable oral solid dosage form comprising two different particles,\n the first particle comprising:\n i) a tacky amorphous polymer selected from the group consisting of polysiloxane, polyisobutylene, polyisoprene, polysulfone, copolymers thereof, and combinations thereof; \n ii) a crystalline polymer curing agent for the amorphous polymer selected from the group consisting of terpene resin, polyvinyl acetate, and combinations thereof; \n iii) an agonist active pharmaceutical ingredient; \n iv) a channelizer selected from the group consisting of talc, colloidal silicon dioxide, zinc stearate, magnesium stearate, powdered sugar, lactose, titanium dioxide, aluminum oxide, and combinations thereof; and \n v) a tackifying agent selected from the group consisting of mineral oil, shellac, silicone oil, and combinations thereof; \n the second particle comprising:\n i) a tacky amorphous polymer selected from the group consisting of polysiloxane, polyisobutylene, polyisoprene, polysulfone, copolymers thereof, and combinations thereof; \n ii) a crystalline polymer curing agent for the amorphous polymer selected from the group consisting of terpene resin, polyvinyl acetate, and combinations thereof; \n iii) an antagonist to the active pharmaceutical ingredient; \n iv) optionally a channelizer selected from the group consisting of talc, colloidal silicon dioxide, zinc stearate, magnesium stearate, powdered sugar, lactose, titanium dioxide, aluminum oxide, and combinations thereof; and \n v) a tackifying agent selected from the group consisting of mineral oil, shellac, silicone oil, and combinations thereof; \n wherein the agonist is releasable and the antagonist is substantially non-releasable upon oral administration of the dosage form.

Metadata:
- Claim Count in Document: 73.0
- Percentile: 86.0
- Lexical Diversity: 1.60784
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13718879', '13544333', '12909614', '10689866', '10700861']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7322635116393921
- 35 USC 102 Novelty (BERT): 0.5153117719339374
- Combined Prediction Score: 0.7105683376688466
- Mean Citation Score: 308.175238
- Max Citation Score: 311.86154
- Similarity Product: 219.53477859866737

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test