PATENT CLAIM ANALYSIS

Application Number: 15978075
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "094610"]

Abstract:
In certain embodiments, the present disclosure provides compositions and methods for treating Pompe disease.

Claim (Index 17):
A nucleic acid construct, comprising a nucleotide sequence that encodes a GAA polypeptide, operably linked to a nucleotide sequence that encodes an internalizing moiety, wherein the nucleic acid construct encodes a chimeric polypeptide comprising: (i) the amino acid sequence set forth in SEQ ID NO: 22 and (ii) an internalizing moiety that promotes transit across cellular membranes via an equilibrative nucleoside transporter 2 (ENT2) transporter and/or that binds DNA with a K D  of less than 100 nM;\n wherein the internalizing moiety is an antibody comprising a heavy chain variable domain comprising the amino acid sequence of SEQ ID NO: 9, or a humanized variant thereof, and a light chain variable domain comprising the amino acid sequence of SEQ ID NO: 10, or a humanized variant thereof.

Metadata:
- Claim Count in Document: 51.0
- Percentile: 93.0
- Lexical Diversity: 1.0
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14769270', '15318256', '14485524', '14100517', '12589118']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7343574196690986
- 35 USC 102 Novelty (BERT): 0.6602831389146879
- Combined Prediction Score: 0.7269499915936576
- Mean Citation Score: 469.374158
- Max Citation Score: 634.4995
- Similarity Product: 619.5874976838231

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test