PATENT CLAIM ANALYSIS

Application Number: 15925500
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "04400A"]

Abstract:
The disclosure provides methods for predicting and/or determining whether a subject has cancer based on the level of expression of BPTF. The disclosure also provides methods for determining whether a cancer in a subject is progressing or regressing based upon the change of expression levels of BPTF between two time points. The disclosure further provides methods to treat a subject with a cancer by administering a polynucleotide comprising an inhibitory BPTF nucleic acid and/or an agent that inhibits the expression or activity of BPTF.

Claim (Index 9):
A method of determining whether a cancer in a subject is progressing or in remission, comprising:\n (i) obtaining a biological sample from a subject at a first time point; (ii) measuring the level of BPTF in the subject's sample from the first time point; (iii) obtaining a biological sample from a subject at a second time point; (iv) measuring the level of BPTF in the subject's sample from the second time point; (v) comparing the levels of BPTF from the first time point with the levels from the second time point; and (vi) determining whether a cancer is progressing or is in recovery based upon the change in levels of BPTF from the two time points, wherein an increase in BPTF levels between the first time point and the second time point indicates that the cancer is in remission, and wherein an increase in BPTF levels between the first time point and the second time point indicates the cancer is progressing, wherein the measuring is performed by (a) performing quantitative RT-PCR using primer pairs to amplify BPTF or (b) converting RNA in the biological sample to aminoallyl-modified cDNA and labelling the cDNA with a dye followed by hybridizing the labeled cDNA to a microarray chip.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 90.0
- Lexical Diversity: 1.74
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14107306', '11635029', '13569845', '13324669', '14744629']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7635127701017529
- 35 USC 102 Novelty (BERT): 0.5224551608008606
- Combined Prediction Score: 0.7394070091716637
- Mean Citation Score: 275.277668
- Max Citation Score: 294.26944
- Similarity Product: 162.8218136782837

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test