PATENT CLAIM ANALYSIS

Application Number: 16179646
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["702", "019000"]

Abstract:
Methods and systems are disclosed for controlling a particle analyzer based at least in part on a generated entrainment factor for a sample. The features include flowing a sample with a series of particles through the particle analyzer, detecting events and calculating an expected frequency of those events based on a distribution, such as a Poisson distribution, and measuring an observed frequency of particle events. An entrainment factor may be generated from a ratio of observed event frequency to expected event frequency. Further adjustment to the particle analyzer maybe performed based on the indicated entrainment factor such as adjusted sorting bias.

Claim (Index 1):
A system for controlling flow of a sample in a flow cytometer, the system comprising:\n a fluidics system comprising a sample tube and a moving fluid column within the sample tube in which particles of a sample move along a common sample path; a detection system for detecting at least one event from each particle as it passes one or more detection stations along the common sample path, each event being assigned a measurement value to form a data point for each particle, the detection system configured to collect a succession of such data points in a first time interval; and a control system operationally associated with the fluidics system, the control system configured to:\n calculate an expected frequency of events occurring during at least a portion of the first time interval based on a characterizing distribution of events during the first time interval; \n generate an observed frequency of events based on a number of data points measured in the portion of the first time interval; \n while particles for the sample are flowing through a flow cytometer, generate an entrainment factor based at least in part on a comparison of the observed frequency to the expected frequency; \n determine that the entrainment factor indicates a level of sample clumping below a threshold; and \n control the detection system or a stream formed from the flow cytometer based on the entrainment factor while particles for the sample are flowing through the flow cytometer.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 98.0
- Lexical Diversity: 1.8
- Patent Class: 702.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14170409', '12387978', '12098340', '10493573', '10286499']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.1663285514325826
- 35 USC 102 Novelty (BERT): 0.5320220010985786
- Combined Prediction Score: 0.2028978963991822
- Mean Citation Score: 215.07155200000005
- Max Citation Score: 355.10165
- Similarity Product: 295.8466426793336

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test