PATENT CLAIM ANALYSIS

Application Number: 16075110
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "293000"]

Abstract:
The present application present application relates to a compound represented by Formula (III) or a pharmaceutically acceptable salt, solvent compound, active metabolite, crystal polymorph, ester, isomer, or prodrug thereof. The application further provides a pharmaceutical composition comprising the compound represented by Formula (III) and a use thereof for preparing a bromodomain inhibitor for preventing or treating various diseases, such as inflammation and cancer, related to the bromodomain.

Claim (Index 6):
The compound or a pharmaceutically acceptable salt, solvate, active metabolite, polymorph, ester, isomer or prodrug thereof according to  claim 1 , wherein\n R 2  is independently selected from the group consisting of 5- to 7-membered heteroaryl containing 1-3 heteroatoms independently selected from the group consisting of N, O and S and 3- to 8-membered heterocycloalkyl containing 1-3 heteroatoms independently selected from the group consisting of N, O and S, wherein the heteroaryl and heterocycloalkyl may be optionally substituted by C 1-6  alkyl, C 2-6  alkenyl or C 3-8  cycloalkyl; preferably, R 2  is independently selected from the group consisting of 5- to 7-membered heteroaryl containing 1-3 heteroatoms independently selected from the group consisting of N, O and S and 3- to 8-membered heterocycloalkyl containing 1-3 heteroatoms independently selected from the group consisting of N, O and S, wherein the heteroaryl and heterocycloalkyl may be optionally substituted by C 1-6  alkyl; and more preferably, R 2  is independently selected from the group consisting of the following structures: wherein R is independently selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 3-8  cycloalkyl-C 1-6  alkyl, optionally substituted aryl-C 1-6  alkyl, optionally substituted heteroaryl-C 1-6  alkyl, optionally substituted heterocycloalkyl-C 1-6  alkyl, optionally substituted C 1-6  alkyl-CO\u2014, optionally substituted aryl-CO\u2014, optionally substituted C 3-8  cycloalkyl-CO\u2014, optionally substituted heteroaryl, optionally substituted heterocycloalkyl-CO\u2014, optionally substituted aryl-SO 2 \u2014, optionally substituted C 1-6  alkyl-SO 2 \u2014, optionally substituted C 3-8  cycloalkyl-SO 2 \u2014, optionally substituted heteroaryl-SO 2 \u2014, optionally substituted C 1-6  alkyl-OCO\u2014 and optionally substituted C 3-8  cycloalkyl-OCO\u2014; preferably, R is independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-8  cycloalkyl, C 1-6  alkyl-CO\u2014, aryl-CO\u2014, C 3-8  cycloalkyl-CO\u2014, heteroaryl, heterocycloalkyl-CO\u2014, aryl-SO 2 \u2014, C 1-6  alkyl-SO 2 \u2014, C 3-8  cycloalkyl-SO 2 \u2014, heteroaryl-SO 2 \u2014, C 1-6  alkyl-OCO\u2014 and C 3-8  cycloalkyl-OCO\u2014; more preferably, R is independently selected from the group consisting of hydrogen, C 1-6  alkyl and heteroaryl; and most preferably, R is independently selected from the group consisting of hydrogen and C 1-6  alkyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.65306
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15305384', '14819541', '14072563', '14207868', '14846545']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8408183920894671
- 35 USC 102 Novelty (BERT): 0.5302390328977575
- Combined Prediction Score: 0.8097604561702961
- Mean Citation Score: 362.686824
- Max Citation Score: 366.06772
- Similarity Product: 294.7767911920166

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test