PATENT CLAIM ANALYSIS

Application Number: 16000954
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "265100"]

Abstract:
Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula I: These compounds are useful in methods for treating cancer, selectively targeting cancerous cells via the proton coupled folate transporter, folate receptor alpha, and/or folate receptor beta pathways, inhibiting GARFTase in cancerous cells, and selectively targeting activated macrophages in a patient having an autoimmune disease, such as rheumatoid arthritis.

Claim (Index 8):
A pharmaceutically acceptable salt of the compound of Formula I: wherein R 1  is one of (a) a hydrogen (H)), (b) an OH, (c) a CH 3 , and (d) NHR wherein R is either a H or an alkyl group having from 1 to 6 carbon atoms, and tautomers of said (b) and said (d); R 2  is one of (a) a hydrogen (H), (b) a CH 3 , (c) an OH, and (d) NHR wherein R is either a H or an alkyl group having from 1 to 6 carbon atoms; A is one of (a) CR\u2032R\u2033, (b) NR\u2032, wherein R\u2032 and R\u2033 are the same or different and are either a H or an alkyl group having from 1 to 6 carbon atoms, and (c) an oxygen (O); wherein the bond at position 5-6 may either be a single or a double bond; wherein the five membered ring has a side chain attached at positions 5, 6 or 7, and optionally includes wherein the carbon atoms at positions 5 and 6, independently, have attached thereto either (a) two hydrogen atoms if the bond between carbon atoms 5 and 6 is a single bond or one hydrogen atom if the bond between carbon atoms 5 and 6 is a double bond, or (b) an alkyl group having from one to six carbon atoms and a hydrogen atom if the bond between carbon atoms at positions 5 and 6 is a single bond or an alkyl group having from one to six carbon atoms if the bond between carbon atoms 5 and 6 is a double bond, and combinations thereof, and R 3  is one of (a) a hydrogen (H), (b) CH 3 , (c) trifluoromethyl, (d) difluoromethyl, (e) monofluoromethyl, (f) methyl ketone, (g) trifluoromethyl ketone, (h) difluoromethyl ketone, (i) monofluoromethyl ketone, (j) formyl, (k) methyl alcohol, (l) methylamine, or (m) a bond; X is either a heterocycloalkyl-carbonyl-L-glutamate group, a heterocycloaryl-carbonyl-L-glutamate group, or a hydrogen (H), and wherein X is a hydrogen then R 4  is a heterocycloalkyl-carbonyl-L-glutamate group or a heterocycloaryl-carbonyl-L-glutamate group, and wherein X is a a heterocycloalkyl-carbonyl-L-glutamate group or a heterocycloaryl-carbonyl-L-glutamate group then R 4  is a hydrogen or a bond; wherein R 5  is the same as R 3  except that R 5  is not a bond; y is an integer ranging from zero up to and including 6; z is an integer ranging from zero up to and including seven, and wherein when A is CR\u2032R\u2033, NR\u2032 and an oxygen (O), the sum total of integers y and z is equal to zero, 5, 6, or 7.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 94.0
- Lexical Diversity: 1.44828
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13558873', '15342359', '12242988', '12260502', '15769223']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.781623309663255
- 35 USC 102 Novelty (BERT): 0.6031952939615233
- Combined Prediction Score: 0.7637805080930818
- Mean Citation Score: 389.297826
- Max Citation Score: 496.8058
- Similarity Product: 492.9970539239167

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test