PATENT CLAIM ANALYSIS

Application Number: 15945428
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "337000"]

Abstract:
The present invention relates to the use of enfumafungin derivative triterpenoid antifungal compounds in combination with other antifungal agents such azoles, polyenes, lipopeptides, and allylamides to treat fungal diseases. More particularly, the invention relates to antifungal combinations of enfumafungin derivative triterpenoids which are inhibitors of (1,3)-β-D-glucan synthesis, in combination with other antifungal agents such as mold-active agents that have activity against molds, including but not limited to voriconazole, isavuconazole, posaconazole, itraconazole and amphotericin B, for the treatment and/or prevention of infections caused by molds.

Claim (Index 1):
A pharmaceutical combination of:\n (a) a first therapeutic agent that is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n X is O or H, H; \n R e  is C(O)NR f R g  or a 6-membered ring heteroaryl group containing 1 or 2 nitrogen atoms wherein the heteroaryl group is optionally mono-substituted on a ring carbon with fluoro or chloro or on a ring nitrogen with oxygen;\n R f , R g , R 6  and R 7  are each independently hydrogen or C 1 -C 3  alkyl; \n R 8  is C 1 -C 4  alkyl, C 3 -C 4  cycloalkyl or C 4 -C 5  cycloalkyl-alkyl; \n R 9  is methyl or ethyl; and \n R 8  and R 9  are optionally taken together to form a 6-membered saturated ring containing 1 oxygen atom; and \n \n (b) a second therapeutic agent that is an azole, a polyene, a purine or pyrimidine nucleotide inhibitor, an orotomide, a Gwt1 inhibitor, a pneumocandin or echinocandin derivative, a protein elongation factor inhibitor, a chitin inhibitor, a mannan inhibitor, a bactericidal/permeability-inducing (BPI) protein product, or an immunomodulating agent.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 91.0
- Lexical Diversity: 1.52308
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12461318', '13058227', '12680472', '11727927', '15528457']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7646492899265243
- 35 USC 102 Novelty (BERT): 0.630553920712855
- Combined Prediction Score: 0.7512397530051573
- Mean Citation Score: 446.761362
- Max Citation Score: 581.1538
- Similarity Product: 530.1177430505038

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test