PATENT CLAIM ANALYSIS

Application Number: 15898387
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["540", "509000"]

Abstract:
The present invention relates to processes and intermediates useful in the preparation of biologically active molecules, especially in the synthesis of Respiratory Syncytial Virus (RSV) inhibitors. The present invention also relates to processes and intermediates for the preparation of compounds of formula (I): In particular, the present invention also relates to processes and intermediates for the preparation of compound I-a:

Claim (Index 1):
A process for preparing a compound of formula (I), wherein\n {circle around (A)} is an optionally substituted aryl or optionally substituted heteroaryl; each n is independently selected from 1 and 2; \n m is 0, 1, 2, 3, or 4; and \n R 1  is selected from the group consisting of: \n 1) optionally substituted \u2014C 1 -C 8  alkyl; \n 2) optionally substituted \u2014C 3 -C 8  cycloalkyl; \n 3) optionally substituted 3- to 12-membered heterocyclic; \n alternatively, two adjacent R 1  groups are taken together with the carbon atoms to which they are attached to form a fused ring; two geminal R 1  groups are taken together with the carbon atom to which they are attached to form a spiro ring; or two R 1  groups on nonadjacent carbon atoms are taken together to form a bridging group, such as \u2014CH 2 \u2014 or \u2014CH 2 CH 2 \u2014; \n said process comprising the steps of: (a) reacting a compound of formula (VII), wherein R 7  is selected from the group consisting of hydrogen, C 1 -C 8  alkyl, C 2 -C 8  alkenyl, C 2 -C 8  alkynyl, C 3 -C 8  cycloalkyl, C 3 -C 8  cycloalkenyl, 3- to 8-membered heterocyclic, aryl, and heteroaryl; and X is a leaving group; with a compound of formula (VII-X), wherein PG is hydrogen or an amine protecting group; to produce a compound of formula (VIII): (b) reacting the compound of formula (VIII) with a compound of formula (IX): to produce a compound of formula (X): (c) reacting the compound of formula (X) with a compound of formula (III) wherein R 5  is selected from the group consisting of \u2014O(CO)O\u2014R 6 , optionally substituted aryl, and optionally substituted heteroaryl; and R 6  is selected from the group consisting of optionally substituted C 1 -C 8  alkyl, optionally substituted C 2 -C 8  alkenyl, optionally substituted C 2 -C 8  alkynyl, optionally substituted C 3 -C 8  cycloalkyl, optionally substituted C 3 -C 8  cycloalkenyl, optionally substituted 3- to 8 membered heterocyclic, optionally substituted aryl, and optionally substituted heteroaryl; to produce a compound of formula (V), (d) reacting the compound of formula (V) with a cyclizing reagent to form the compound of formula (I).

Metadata:
- Claim Count in Document: 39.0
- Percentile: 88.0
- Lexical Diversity: 1.86486
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15216119', '15863216', '14142666', '12443177', '14015790']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6179756675110212
- 35 USC 102 Novelty (BERT): 0.5112377712541071
- Combined Prediction Score: 0.6073018778853297
- Mean Citation Score: 238.02312200000003
- Max Citation Score: 278.66486000000003
- Similarity Product: 229.8594235069156

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test