PATENT CLAIM ANALYSIS

Application Number: 15862999
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "005000"]

Abstract:
A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described. The method involves modifying a clade F cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate β-galactose residue. The modification may involve retargeting the vector by temporarily functionally ablate AAV9 binding in a subset of cells, thereby redirecting the vector to another subset of cells. Alternatively, the modification may involve increasing cellular update efficiency by treating the cells with a neuraminidase to expose cell surface β-galactose. Also provided are compositions containing the AAV9 vector and a neuraminidase. Also provided is a method for purifying AAV9 using β-galactose linked to solid support. Also provided are mutant vectors which have been modified to alter their targeting specificity, including mutant AAV9 in which the galactose binding domain is mutated and AAV in which an AAV9 galactose binding domain is engineered.

Claim (Index 16):
The recombinant AAV9 vector according to  claim 15 , wherein the native AAV9 amino acid is replaced with an alanine.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 86.0
- Lexical Diversity: 1.92308
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15092482', '14777070', '14399428', '11698505', '14543459']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6705153265975691
- 35 USC 102 Novelty (BERT): 0.5388281381559579
- Combined Prediction Score: 0.6573466077534079
- Mean Citation Score: 369.73065800000006
- Max Citation Score: 397.72156
- Similarity Product: 281.19417543043136

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test