PATENT CLAIM ANALYSIS

Application Number: 15764830
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["348", "080000"]

Abstract:
This application discloses a tools and techniques for using a remote-focusing element (such as an electro-tunable lens) to provide enhanced focusing in an all-optical digital scanning microscopy system. The remote-focusing element can imaging of different sections of the specimen without moving the specimen itself, while at the same time providing the ability to correct for non-uniform indices of refraction in the imaged specimen and/or the surrounding medium which can cause misalignment between the imaged plane and the illuminated plane, which can result in loss focus in the imaged section of the specimen. The remote-focusing element can also obviate the need to move the detection stage and/or the illumination stage of the system to image different sections, eliminating vibration during the imaging process.

Claim (Index 1):
A remote focusing all-optical digital scanning light sheet microscopy system comprising:\n an all-optical digital scanning light sheet microscope having at least:\n illumination side optics generating a light sheet, \n a detection objective aligned having a detection axis substantially orthogonal to the light sheet, and \n image detector having an imaging sensor for recording images captured by the detection objective; \n an electro-tunable lens positioned in a detection path of the detection objective, wherein a focal length of the electro-tunable lens is adjustable electrically as a function of electrical current supplied by a driver; a microscope controller communicatively coupled with the electro-tunable lens, the image detector, and the scanning mirror, the microscope controller comprising:\n at least one processor; \n non-transitory computer readable media having encoded thereon computer software comprising a set of instructions executable by the at least one processor to:\n align, via the electro-tunable lens, a focal plane of the detection objective to an expected position of an illumination plane of the light sheet, the light sheet illuminating a first section of a specimen; \n capture, via the image detector, a first image of the first section detected by the detection objective; \n determine whether the first image of the first section is within a focus tolerance range, wherein the focus tolerance range specifies threshold focus levels for a captured image; \n identify at least one out-of-focus feature in the first image of the first section; \n adjust, via the driver of the electro-tunable lens, the focal length of the electro-tunable lens, wherein the focal plane of the detection objective is shifted to coincide with the position of the illumination plane of the light sheet at the at least one out-of-focus feature; and \n capture a second image of the first section having the at least one out-of-focus feature in focus.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 90.0
- Lexical Diversity: 1.68831
- Patent Class: 348.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13968220', '15266310', '15719299', '15695484', '15680075']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5932935735269551
- 35 USC 102 Novelty (BERT): 0.4745610989061152
- Combined Prediction Score: 0.5814203260648712
- Mean Citation Score: 189.394448
- Max Citation Score: 194.38135
- Similarity Product: 151.21059236295224

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test