PATENT CLAIM ANALYSIS

Application Number: 16002602
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-09
Patent Classification: ["435", "440000"]

Abstract:
The present disclosure provides compositions and methods for binding and/or cleaving a single stranded target nucleic acid. Subject compositions include a Cas9 polypeptide, a guide nucleic acid, and a PAMmer. A subject PAMmer is a single stranded oligonucleotide having a proto spacer adjacent motif (PAM) sequence and at least one of: a specifity segment positioned 5′ of the PAM sequence, and an orientation segment positioned 3′ of the PAM sequence. In some embodiments, the Cas9 polypeptide is a variant Cas9 polypeptide having reduced nuclease activity relative to a corresponding wild type Cas9 polypeptide. In some cases, methods of binding are for visualizing single stranded target nucleic acids using a detectable label. In some cases, methods of binding are for isolating, collecting, and/or analyzing at least one of: (i) bound single stranded target nucleic acids; and (ii) polypeptides associated with bound single stranded target nucleic acids.

Claim (Index 91):
The method according to  claim 90 , wherein the detectable label of the guide nucleic acid is a directly detectable label.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 2.1
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15036298', '15574030', '13842859', '15138604', '15803424']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.3471939162945824
- 35 USC 102 Novelty (BERT): 0.6052743053800264
- Combined Prediction Score: 0.3730019552031268
- Mean Citation Score: 500.02863800000006
- Max Citation Score: 685.9368
- Similarity Product: 419.8458101148605

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test