PATENT CLAIM ANALYSIS

Application Number: 16272934
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-08
Patent Classification: ["544", "281000"]

Abstract:
The invention concerns novel substituted pyrazolo- and triazolo-pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.

Claim (Index 2):
The compound as claimed in  claim 1  wherein\n X is N or CR 6  wherein R 6  is hydrogen or halo; \n R 1  is CH 3  or CH 2 CH 3 , and R 1\u2032  is hydrogen; or R 1  and R 1\u2032  are taken together with the carbon atom to which they are attached to form cyclopropyl; and R 2  is C 3-6 alkyl and R 3  is C 1-4 alkyl; \n or the \n moiety is a radical of formula: wherein R 1  is CH 3  or CH 2 CH 3 , and R 1\u2032  is hydrogen; or R 1\u2032  is absent in radical (a-6); or R 1  and R 1\u2032  are taken together with the carbon atom to which they are attached to form cyclopropyl; and radical (a-1) to (a-15) are optionally substituted with one or two substituents each independently selected from C 1-2 alkyl and halo; R 4  is C 1-6 alkyl; polyhaloC 1-4 alkyl; C 3-6 cycloalkyl; C 1-4 alkyl substituted with one C 3-6 cycloalkyl; or NR 7 R 8  wherein R 7  is selected from hydrogen and C 1-4 alkyl; R 8  is C 1-4 alkyl or C 3-6 cycloalkyl; or R 7  and R 8  are taken together with the nitrogen to which they are attached to form pyrrolidinyl or piperidinyl; R 5  is C 3-6 cycloalkyl; Heteroaryl; phenyl substituted with 1, 2 or 3 substituents each independently selected from hydroxy; halo; C 1-6 alkyl; C 1-6 alkyl substituted with one substituent selected from hydroxy, hydroxycarbonyl and aminocarbonyl; C 3-6 alkenyl substituted with one or two substituents selected from C 1-6 alkyl, hydroxy, hydroxycarbonyl and aminocarbonyl; C 3-6 cycloalkyl substituted with one hydroxycarbonyl; C 1-6 alkyloxy; cyano; B(OH) 2 ; hydroxycarbonyl; CO\u2014NHOH; CO\u2014NR 9 R 10 ; CO\u2014NH\u2014NR 9 R 10 ; NR 9 R 10 ; NH\u2014CO\u2014R 11 ; NH\u2014CO\u2014O\u2014R 11 ; NH\u2014CO\u2014NH\u2014R 11 ; NH\u2014CS\u2014NH\u2014R 11 ; NH\u2014C\u2550(N\u2014CN)\u2014NH\u2014R 11 ; aminosulfonyl; mono- or di(C 1-4 alkyl)aminosulfonyl; and Heterocycle; wherein R 9  and R 10  are each independently selected from hydrogen; C 1-6 alkyl; SO 2 \u2014R 12 ; and C 1-6 alkyl substituted with C 3-6 cycloalkyl, mono- or di(C 1-4 alkyl)amino, or Heterocycle; R 11  is C 1-6 alkyl; C 3-6 alkenyl; C 3-6 cycloalkyl; Aryl; Heterocycle; or C 1-6 alkyl substituted with one substituent selected from C 3-6 cycloalkyl, C 1-4 alkyloxy, hydroxy, cyano, hydroxycarbonyl, aminocarbonyl, mono- or di(C 1-4 alkyl)aminocarbonyl, C 1-4 alkylcarbonylamino, and Heterocycle; R 12  is C 1-4 alkyl, or C 3-6 cycloalkyl; Heteroaryl is thienyl, pyridinyl, 1-benzopyrazolyl, 2,3-dihydro-1H-indolyl, 2-oxo-2,3-dihydro-1H-indolyl, quinolinyl, 2-oxo-quinolinyl, benzimidazolyl, cinnolinyl, or 2H-chromenyl, wherein each Heteroaryl is optionally substituted with one or two substituents each independently selected from C 1-4 alkyl, halo, aminocarbonyl, and NH\u2014CO\u2014C 3-6 cycloalkyl; Heterocycle is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, furanyl, thienyl, imidazolyl, pyrazolyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, 2-oxo-azepanyl, 2,5-dioxopyrrolidinyl, or 3-oxo-2,3-dihydro-1,2-oxazolyl; wherein each Heterocycle is optionally substituted with one or two substituents each independently selected from C 1-4 alkyl, C 3-6 cycloalkyl, halo and hydroxycarbonyl; Aryl is phenyl substituted with one or two substituents each independently selected from hydrogen and halogen; or a pharmaceutically acceptable acid addition salt thereof.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 99.0
- Lexical Diversity: 1.53846
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15570054', '15534442', '12293545', '11569108', '12988891']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7764509268381381
- 35 USC 102 Novelty (BERT): 0.5692066503018613
- Combined Prediction Score: 0.7557264991845104
- Mean Citation Score: 300.244926
- Max Citation Score: 431.0718
- Similarity Product: 426.070897065854

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test