PATENT CLAIM ANALYSIS

Application Number: 15763366
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "518000"]

Abstract:
Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Claim (Index 60):
The method of  claim 55 , wherein the compound that inhibits ATR is represented by Formula A-II-a: or a pharmaceutically acceptable salt thereof, wherein: R 10  is independently fluoro, chloro, or \u2014C(J 10 ) 2 CN; J 10  is independently H or C 1-2 alkyl; or two occurrences of J 1 , together with the carbon atom to which they are attached, form an optionally substituted 3-4 membered carbocyclic ring; R 3  is independently H; chloro; fluoro; C 1-4 alkyl optionally substituted with 1-3 occurrences of halo; C 3-4 cycloalkyl; \u2014CN; or a C 1-3 aliphatic chain wherein up to two methylene units of the aliphatic chain are optionally replaced with \u2014O\u2014, \u2014NR a \u2014, \u2014C(O)\u2014, or \u2014S(O) z ; L 1  is H; a 3-7 membered aromatic or non-aromatic ring having 0-2 heteroatoms selected from the group consisting of oxygen, nitrogen, or sulfur; or a C 1-6 aliphatic chain wherein up to two methylene units of the aliphatic chain are optionally replaced with \u2014O\u2014, \u2014NR a \u2014, \u2014C(O)\u2014, or \u2014S(O) z ; each L 1  is optionally substituted with C 1-4 aliphatic; \u2014CN; halo; \u2014OH; or a 3-6 membered non-aromatic ring having 0-2 heteroatoms selected from the group consisting of oxygen, nitrogen, or sulfur; L 2  is H; a 3-7 membered aromatic or non-aromatic ring having 0-2 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; or a C 1-6 aliphatic chain wherein up to two methylene units of the aliphatic chain are optionally replaced with \u2014O\u2014, \u2014NR a \u2014, \u2014C(O)\u2014, or \u2014S(O) z ; each L 2  is optionally substituted with C 1-4 aliphatic; \u2014CN; halo; \u2014OH; or a 3-6 membered non-aromatic ring having 0-2 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; or L 1  and L 2 , together with the nitrogen to which they are attached, form a Ring D; Ring D is optionally substituted with 0-5 occurrences of J G ; L 3  is H; C 1-3 aliphatic; or CN; Ring D is independently a 3-7 membered heterocyclyl ring having 1-2 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; or an 7-12 membered fully saturated or partially unsaturated bicyclic ring having 1-5 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; J G  is independently halo; \u2014CN; \u2014N(R o ) 2 ; \u2550O; a 3-6 membered carbocycyl; a 3-6 membered heterocyclyl having 1-2 heteroatoms selected from the group consisting of oxygen nitrogen, and sulfur; or a C 1-4 alkyl chain wherein up to two methylene units of the alkyl chain are optionally replaced with \u2014O\u2014, \u2014NR a \u2014, \u2014C(O)\u2014, or \u2014S(O) z ; each J G  is optionally substituted with 0-2 occurrences of J K . two occurrences of J G  on the same atom, together with the atom to which they are joined, form a 3-6 membered ring having 0-2 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; or two occurrences of J G , together with Ring D, form a 6-10 membered saturated or partially unsaturated bridged ring system; J K  is a 3-7 membered aromatic or non-aromatic ring having 0-2 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; z is 0, 1, or 2; and R a  and R o  are H or C 1-4 alkyl.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 90.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15031426', '15665506', '12988755', '14596052', '15081076']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8082504115151424
- 35 USC 102 Novelty (BERT): 0.5201311722551171
- Combined Prediction Score: 0.7794384875891399
- Mean Citation Score: 311.3153240000001
- Max Citation Score: 332.41208
- Similarity Product: 264.74164244466783

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test