PATENT CLAIM ANALYSIS

Application Number: 16262490
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["424", "093210"]

Abstract:
The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and disorders.

Claim (Index 2):
A chimeric antigen receptor (CAR) comprising:\n a) a signal peptide; b) a light chain variable region comprising the amino acid sequence: DIVMTQSHKFMSTSIGARVSITCKASQDVRTAVAWYQQKPGQSPKLLIYS   ASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYGTPPWTFG   GGTKLEIK; c) a linker peptide; d) a heavy chain variable region comprising the amino acid sequence: EVQLVESGGGLVKPGGSLKLSCEASRFTFSSYAMSWVRQTPEKRLEWVAA   ISGGGRYTYYPDSMKGRFTISRDNAKNFLYLQMSSLRSEDTAMYYCARHY   DGYLDYWGQGTTLTVSS; e) a CD8\u03b1 hinge polypeptide; f) a CD8\u03b1 transmembrane domain; g) a CD28 costimulatory domain; and h) a CD3\u03b6 signaling domain.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 99.0
- Lexical Diversity: 1.14286
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16012432', '15669562', '14042306', '15524158', '15475681']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7225443735202972
- 35 USC 102 Novelty (BERT): 0.5873296082020899
- Combined Prediction Score: 0.7090228969884764
- Mean Citation Score: 358.415838
- Max Citation Score: 515.00806
- Similarity Product: 429.56411359074826

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test