PATENT CLAIM ANALYSIS

Application Number: 16277785
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "362000"]

Abstract:
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a different biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.

Claim (Index 2):
The compound of  claim 1 , having the following structure: wherein:\n R 1  is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, hydroxy-lower alkenyl, and phenyl-lower alkyl, \n R 2  is selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, C 3-6  cycloalkyl, phenyl alkyl, aralkyl, alkenyl, hydroxyalkenyl, cyano, branched cyano, phenyl, halophenyl, alkoxy, alkoxyphenyl, acyl, acylamino, aralkyl, aralkyl wherein the aryl radical is mono- to tri-substituted by alkyl, alkoxy, OH, F, and/or Cl or mono substituted by methylenedioxy, or R 1  and R 2  can be joined together with the N to form heterocyclic structure; \n R 3  is H or lower alkyl; \n R 4  is H or lower alkyl; \n R 5  is H or lower alkyl; \n R 6  is H or lower alkyl; \n R 7  is H or lower alkyl; \n Ar is an aromatic-containing moiety; \n X is a spacer moiety; and \n POLY is a water-soluble, non-peptidic oligomer.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 99.0
- Lexical Diversity: 1.55
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12530412', '15690106', '12674139', '14266317', '13319924']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8142478786336235
- 35 USC 102 Novelty (BERT): 0.5257208101683134
- Combined Prediction Score: 0.7853951717870924
- Mean Citation Score: 298.73018799999994
- Max Citation Score: 345.89764
- Similarity Product: 260.1627862079215

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test