PATENT CLAIM ANALYSIS

Application Number: 16279291
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "258100"]

Abstract:
Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b′ to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.

Claim (Index 11):
A process for preparing the condensed-ring pyrimidylamino derivative, the tautomer, the mesomer, the racemate, the stereoisomer, the pharmaceutically acceptable salt or the prodrug thereof according to  claim 1 , comprising: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b\u2032 to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction; in formula I-a, formula I-b\u2032 and formula I, both X and U are CH, Y is CR 4 , W is C, the definitions of ring A, ring B, V, R 1 , R 2 , R 3 , R 4 , m and n are as defined in  claim 1 , R 7  is R 2  that is protected by Boc; or, optionally, a base is also included in the coupling reaction, where the base is sodium carbonate, potassium carbonate or cesium carbonate, and the molar ratio of the base to the compound I-a is from 1:1 to 5:1.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 99.0
- Lexical Diversity: 1.95455
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15568999', '15985848', '15559181', '15746254', '15025618']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7449722412375217
- 35 USC 102 Novelty (BERT): 0.588434154224993
- Combined Prediction Score: 0.7293184325362688
- Mean Citation Score: 351.83731
- Max Citation Score: 477.65143
- Similarity Product: 449.8401584516561

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test