PATENT CLAIM ANALYSIS

Application Number: 15752994
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["530", "387300"]

Abstract:
A refolding process of Ranibizumab is disclosed wherein the solubilized solution of heavy chain and/or light chain of Ranibizumab treated with refolding buffer under suitable conditions including pH, temperature and incubation period and the pH and temperature shift is performed at suitable interval to obtain high quality and quantity of refolded protein.

Claim (Index 1):
A process for recovering refolded Ranibizumab, the process comprising the steps of;\n a) isolating a light chain and/or heavy chain of Ranibizumab from a bacterial host cell; b) solubilizing said light chain and/or heavy chain of Ranibizumab in a first buffer solution comprising a chaotropic agent and/or reducing agent at a suitable pH; c) refolding the solubilized light chain and/or heavy chain of Ranibizumab in a second buffer solution in a first incubation period under suitable pH and temperature conditions and then shifting the pH and temperature to lower pH and higher temperature in a second incubation period to obtain refolded Ranibizumab; and d) recovering said refolded Ranibizumab.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 88.0
- Lexical Diversity: 1.35
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13668182', '14922802', '13634801', '11341013', '14766849']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6407835648629271
- 35 USC 102 Novelty (BERT): 0.522898232376845
- Combined Prediction Score: 0.6289950316143189
- Mean Citation Score: 278.37254
- Max Citation Score: 314.81305
- Similarity Product: 222.10627570124865

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test