PATENT CLAIM ANALYSIS

Application Number: 15776574
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "265100"]

Abstract:
The present invention relates to compounds of formulae I, or pharmaceutically acceptable salts or esters thereof, wherein: R 1  is selected from H and CO—NR 8 R 9 , wherein R 8  and R 9  are each independently selected from H, alkyl, cycloalkyl and mono or bicyclic heterocycloalkyl, wherein said alkyl group is optionally substituted by one or more R 12  groups, and said heterocycloalkyl is optionally substituted by R 10  or R 12 ; or R 8  and R 9  are linked, together with the nitrogen to which they are attached, to form a heterocycloalkyl group optionally containing one or more additional heteroatoms, and optionally substituted by one or more groups select from R 10  and (CH 2 ) m R 12 ; R 2  is selected from H and alkyl, wherein said alkyl group is optionally substituted by one or more R 12  groups; R 3  is selected from alkyl, cycloalkyl and heterocycloalkyl, each of which may be optionally substituted by halo, OH or alkoxy; Z 1 , Z 2 , Z 3  and Z 4  are all C; R 4 , R 5 , R 6  and R 7  are each independently selected from H, alkyl, CN, NO 2 ,OH, alkoxy, NHCO-alkyl, halo and haloalkyl; or Z 1 , Z 3  and Z 4  are all C, Z 2  is N, R 5  is absent and R 4 , R 6  and R 7  are as defined above; or Z 1 , Z 3  and Z 4  are all C, Z 1  is N, R 4  is absent and R 5 , R 6  and R 7  are as defmed above; each R 10  and R11 is independently alkyl; each R 12  is independently selected from CO 2 R 10 , COOH, OH, alkoxy, haloalkyl, NH 2 , NHR 10 , NR 10 R 11 , heteroaryl and heterocycloalkyl; R 13  is H or halo. Further aspects relate to pharmaceutical compositions and therapeutic uses of said compounds in the treatment of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, inappropriate cellular inflammatory responses, or neurodegenerative disorders, preferably tauopathies, even more preferably, Alzheimer's disease.

Claim (Index 5):
A compound according to  claim 1  wherein R 3  is selected from alkyl, cyclopropyl, cyclobutyl, cyclopentyl, tetrahydrofuranyl and tetrahydropyranyl, each of which may be optionally substituted by one or more groups selected from fluoro, OH and methoxy.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 93.0
- Lexical Diversity: 3.1875
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15776536', '15576101', '12083534', '15545149', '15337184']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7637227087948603
- 35 USC 102 Novelty (BERT): 0.5419850073504906
- Combined Prediction Score: 0.7415489386504233
- Mean Citation Score: 332.326898
- Max Citation Score: 368.1738
- Similarity Product: 296.91916288862234

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test