PATENT CLAIM ANALYSIS

Application Number: 15746325
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["359", "385000"]

Abstract:
The invention relates to the high-resolution spectrally selective scanning microscopy of a sample. The sample is excited with illumination radiation in order to emit fluorescence radiation such that the illumination radiation is bundled into an illumination spot in or on the sample. The illumination spot is diffraction-limited in at least one spatial direction and has a minimum extension in said spatial direction. Fluorescence radiation emitted from the illumination spot is imaged into a diffraction image lying on an image plane in a diffraction-limited manner and is detected with a spatial resolution which resolves a structure of a diffraction image of the fluorescence radiation emitted from the illumination spot. The illumination spot is moved into different scanning positions relative to the sample in increments which are smaller than half the minimum extension of the illumination spot. An individual image of the structure of the diffraction image of the fluorescence radiation emitted from the illumination spot is generated for each scanning position, and an image of the sample is generated from the individual images, said image having a resolution which is increased over a resolution threshold of the imaging process. The fluorescence radiation emitted from the illumination spot is imaged into a diffraction image in a diffraction-limited manner onto a detector, said detector having an inlet surface with multiple adjacently lying local channels on the image plane. The local channels determine the spatial resolution with which the structure of the diffraction image of the fluorescence radiation emitted from the illumination spot is resolved, and the fluorescence radiation emitted from the illumination spot is spectrally evaluated. In precisely one first local channel of the adjacently lying local channels, the fluorescence radiation is guided onto a spectrometer and spectrally analyzed by means of the spectrometer, and in the remaining second local channels of the adjacently lying local channels, the fluorescence radiation is guided onto a respective detector element which detects solely the intensity of the fluorescence radiation.

Claim (Index 12):
A method for high-resolution spectrally selective scanning microscopy of a sample, comprising the steps of:\n exiting the sample by illumination radiation to emit fluorescent radiation including focusing the illumination radiation into an illumination spot in or on the sample, wherein the illumination spot is diffraction-limited in at least one spatial direction and has a minimum extent in this spatial direction; imaging fluorescent radiation coming from the illumination spot in diffraction-limited manner into a diffraction image located in an image plane; capturing the diffraction image with a spatial resolution that resolves a structure of the diffraction image; displacing the illumination spot relative to the sample into different scanning positions at an increment size of less than half the minimum extent of the illumination spot; producing individual images of the structure of the diffraction image for each scanning position by\n imaging the fluorescent radiation into the diffraction image on a detector which has, in the image plane, an entrance surface having a plurality of adjacent location channels, which define the spatial resolution, \n guiding the fluorescent radiation to a spectrometer for exactly one first the location channels and spectrally evaluating this radiation, and \n guiding the fluorescent radiation in each remaining location channel to an individual detector element which does not perform spectral evaluation and captures the radiation only with respect to the intensity; and \n generating an image of the sample from the individual images, which image has a resolution that is increased over a resolution limit of the optical imaging.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 86.0
- Lexical Diversity: 3.19811
- Patent Class: 359.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15764238', '14373602', '15457486', '14490806', '14457833']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8221058750979839
- 35 USC 102 Novelty (BERT): 0.5311836214849022
- Combined Prediction Score: 0.7930136497366758
- Mean Citation Score: 312.2490380000001
- Max Citation Score: 398.87204
- Similarity Product: 342.7112612409616

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test