PATENT CLAIM ANALYSIS

Application Number: 16107605
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "293000"]

Abstract:
Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.

Claim (Index 19):
A compound of formula (K): or a salt thereof, wherein:\n n is an integer from 4 to 21; \n X is \u2014NH\u2014 or \u2014NH(C\u2550O)\u2014; \n R 1  is C 3 -C 6  alkyl, \u2014(CH 2 ) p OR 1a , \u2014(CH 2 ) p NHR 1b  or \u2014(CH 2 ) p R 1c ; where R 1a  and R 1b  are independently C 1 -C 3  alkyl; R 1c  is C 3 -C 4  cycloalkyl; and p is 1 or 2; \n R 2  is NHR 2a ; where R 2a  is H, OH, NH 2 , or methyl; \n each R 3  is independently halogen, C 1 -C 8  alkyl, \u2014(C 1 -C 7  alkylene)-NH 2 , or \u2014CH 2 -phenylene-CH 2 NH 2 ; \n q is 0, 1, 2, 3, or 4; and \n R 4a  and R 4b  are independently H or C 1 -C 8  alkyl, \n provided that the compound is other than 2-butyl-1-(4-((hexadecylamino)methyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-amine or N-(4-((4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl)benzyl)palmitamide.

Metadata:
- Claim Count in Document: 54.0
- Percentile: 96.0
- Lexical Diversity: 1.67442
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15848349', '13475284', '14279416', '15793820', '13832179']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8092570381868179
- 35 USC 102 Novelty (BERT): 0.5209726327526064
- Combined Prediction Score: 0.7804285976433968
- Mean Citation Score: 308.7829920000001
- Max Citation Score: 313.4957
- Similarity Product: 213.4091371904731

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test