PATENT CLAIM ANALYSIS

Application Number: 15743424
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["546", "276700"]

Abstract:
The invention provides compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D 1 , D 2 , D 3 , X, Y, A 1 , A 2 , R 1 , R 5  and the subscript a are as described herein. The compounds are CETP inhibitors and are useful for raising FIDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:

Claim (Index 2):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof:\n wherein R 1  is \u2014C 1 -C 5  alkyl, \u2014OC 1 -C 5  alkyl, halogen, \u2014NR 6 R 7 , HET(3), or C 3 -C 6  cycloalkyl optionally having 1-2 double bonds,\n wherein said \u2014C 1 -C 5  alkyl and \u2014OC 1 -C 5  alkyl of R 1  are optionally substituted with 1-7 halogens, and \n wherein said HET(3) and C 3 -C 6  cycloalkyl optionally having 1-2 double bonds of R 1  are optionally substituted with 1-3 substituent groups which are each independently halogen, CH 3 , CF 3 , OCH 3 , or OCF 3 ; \n at least one of D 1 , D 2 , and D 3  is CR 2 , CR 3 , or CR 4 ; R 2 , R 3 , and R 4  are each independently H, \u2014C 1 -C 5  alkyl, \u2014OC 1 -C 5  alkyl, or halogen, wherein said \u2014C 1 -C 5  alkyl and \u2014OC 1 -C 5  alkyl of R 2 , R 3 , and R 4  are optionally substituted with 1-7 halogens; each R 5  is independently \u2014C 1 -C 5  alkyl, \u2014OC 1 -C 5  alkyl, or halogen, wherein said \u2014C 1 -C 5  alkyl and \u2014OC 1 -C 5  alkyl of R 5  are optionally substituted with 1-7 halogens; A 1  is phenyl, HET(1), or C 3 -C 6  cycloalkyl optionally having 1-2 double bonds, wherein A 1  is optionally substituted with one substituent group Z and is optionally substituted with 1-3 groups which are each independently halogen, \u2014OH, \u2014CN, \u2014C 1 -C 5 alkyl optionally substituted with 1-7 halogens, or \u2014OC 1 -C 5 alkyl optionally substituted with 1-7 halogens; A 3  is phenyl, C 3 -C 6  cycloalkyl optionally having 1-2 double bonds, or HET(1),\n wherein A 3  is optionally substituted with 1-3 groups which are each independently \u2014C 1 -C 5  alkyl optionally substituted with 1-7 halogens, \u2014OC 1 -C 5  alkyl optionally substituted with 1-7 halogens, \u2014OH, or halogen, and \n wherein A 3  is optionally substituted with one group which is HET(2), \u2014C 1 -C 2  alkylene-CO 2 R 8 , \u2014C 1 -C 2  alkylene-C(O)NR 6 R 7 , \u2014C 1 -C 2  alkylene-SO 2 NR 6 R 7 , \u2014CO 2 R 8 , \u2014C(O)NR 6 R 7 , \u2014SO 2 NR 6 R 7 , or \u2014C(O)NR 6 C 3 -C 6 cycloalkyl;\n wherein said C 3 -C 6 cycloalkyl of \u2014C(O)NR 6 C 3 -C 6 cycloalkyl is optionally substituted with 1-3 substituents which are independently selected from halogen, C 1 -C 2 alkyl, and \u2014CN; \n wherein said \u2014C 1 -C 2 alkylene of \u2014C 1 -C 2  alkylene-CO 2 R 8 , \u2014C 1 -C 2 alkylene-C(O)NR 6 R 7 , or \u2014C 1 -C 2 alkylene-SO 2 NR 6 R 7  is optionally substituted with 1-3 halogens; and \n wherein HET(2) is optionally substituted with 1-3 groups which are each independently halogen, \u2014C 1 -C 5  alkyl optionally substituted with 1-7 halogens, \u2014OC 1 -C 5  alkyl optionally substituted with 1-7 halogens, or NR 6 R 7 ; and \n \n A 2  is phenyl or HET(1), wherein A 2  is optionally substituted with 1-3 substituent groups which are each independently C 1 -C 5  alkyl optionally substituted with 1-7 halogens, \u2014OC 1 -C 5  alkyl optionally substituted with 1-7 halogens, halogen, \u2014OH, \u2014CN, or C 3 -C 6  cycloalkyl;\n wherein said C 3 -C 6 cycloalkyl is optionally substituted with 1-3 substituents which are each independently halogen, CF 3 , CH 3 , \u2014OCF 3 , or \u2014OCH 3 .

Metadata:
- Claim Count in Document: 16.0
- Percentile: 86.0
- Lexical Diversity: 1.63043
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14908180', '13660010', '15329284', '15104351', '15028306']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8423544665182436
- 35 USC 102 Novelty (BERT): 0.5669496746398038
- Combined Prediction Score: 0.8148139873303997
- Mean Citation Score: 434.067694
- Max Citation Score: 454.36414
- Similarity Product: 419.7874118234968

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test