PATENT CLAIM ANALYSIS

Application Number: 16063297
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "619000"]

Abstract:
The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R 1  is —OH, R 2  is —NO 2  and R 3  is H, R 4  and R 5  are H, one of R 6  and R 7  is selected from H, —CONH 2 , and —CONR 9 2 , and the other one is selected from —CONR 9 2  and —CONR 11 R 9 , wherein R 9  and R 11  are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.

Claim (Index 1):
A compound characterized by a general formula (A), wherein\n R 1  is selected from, \u2014OH, \u2014SH and \u2014NH 2 ; \n R 2  is selected from \u2014NO 2 , \u2014SO 3 H, \u2014SO 2 \u2014OR 11 , \u2014SO 2 \u2014NH 2 , \u2014SO 2 \u2014NHR 11 , \u2014SO 2 \u2014NR 11 2 , \u2014PO 3 H, \u2014PO 2 \u2014OR 11 , \u2014CN, \u2014COR 11 , \u2014CO 2 R 11 , \u2014CONHR 11 , \u2014CONR 11 2 , \u2014CF 3 , and halogen; \n R 3  is selected from H, \u2014NO 2 , \u2014SO 3 H, \u2014SO 2 \u2014OR 11 , \u2014SO 2 \u2014NH 2 , \u2014SO 2 \u2014NHR 11 , \u2014SO 2 \u2014NR 11 2 ; \u2014PO 3 H, \u2014PO 2 \u2014OR 11 , \u2014CN, \u2014COR 11 , \u2014CO 2 R 11 , \u2014CONHR 11 , \u2014CONR 11 2 , \u2014CF 3 , and halogen; \n R 4  and R 5  are independently selected from \u2014H, substituted C 1 -C 6  alkyl, unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 2 -C 6  alkenyl, substituted or unsubstituted C 3 -C 6  cycloalkyl, halogen, \u2014CN and \u2014NO 2 ; \n one of R 6  and R 7  is selected from \u2014CONR 9 R 11 , \u2014CONR 9 2 , \u2014COR 9 , \u2014COOR 9 , \u2014SO 2 \u2014OH, \u2014SO 2 R 9 , \u2014SO 2 \u2014OR 9 , \u2014SO 2 \u2014OR 11 , \u2014SO 2 NHR 11 , \u2014SO 2 NR 9 R 11 , \u2014NO 2 , \u2014CN, \u2014CF 3  and \u2014SO 2 NR 9 2 ; \n the other one of R 6  and R 7  is selected from H, \u2014CONH 2 , \u2014COOH, \u2014SO 2 \u2014OH, \u2014SO 2 NH 2 , \u2014Y\u2014R 9 , \u2014Y\u2014R 9 2  and \u2014R 9 , \n wherein\n R 9  is R 10 \u2014(Y\u2014R 10 ) n  \n Y is selected from \u2014CONR 11 \u2014, \u2014CO\u2014, \u2014COO\u2014, \u2014SO 3 \u2014, \u2014SO 2 NH\u2014, \u2014NR 11 \u2014, \u2014O\u2014, \u2014NR 11 CO\u2014, \u2014OCO\u2014, \u2014NR 11 COO\u2014, \u2014NR 11 CONR 11 \u2014, \u2014OCONR 11 \u2014 and \u2014OCOO\u2014 \n n is an integer selected from 0, 1, 2, 3 and 4, \n each R 10  independently of any other R 10  is selected from a substituted or unsubstituted C 1 -C 8  alkyl, substituted or unsubstituted a C 2 -C 8  alkenyl, a substituted or unsubstituted C 2 -C 8  alkynyl, substituted or unsubstituted a C 3 -C 10  cycloalkyl and a substituted or unsubstituted 5- to 10-membered aryl or heteroaryl; and \n each R 11  independently of any other R 11  is H or an unsubstituted C 1 -C 6  alkyl.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 94.0
- Lexical Diversity: 1.98649
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['11202611', '15437618', '11948239', '13002475', '10621276']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7540435071648043
- 35 USC 102 Novelty (BERT): 0.5014808298097946
- Combined Prediction Score: 0.7287872394293033
- Mean Citation Score: 212.110892
- Max Citation Score: 218.88503
- Similarity Product: 153.7405068492603

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test