PATENT CLAIM ANALYSIS

Application Number: 16249024
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["514", "300000"]

Abstract:
Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

Claim (Index 29):
A compound having the structure of formula (III): or a pharmaceutically acceptable salt thereof, wherein R 1  is 9 membered heteroaryl optionally substituted with one or more R 4 ; R 3  is selected from the group consisting of hydrogen, C 6-10  aryl, \u2014(CH 2 ) n -(5-10 membered heteroaryl), \u2014(CH 2 ) n \u2014(C 3-10  carbocyclyl), and 3-10 membered heterocyclyl, each optionally substituted with one or more R 9 ; ring A is selected from the group consisting of phenyl, 5-6 membered heteroaryl, C 3-7  carbocyclyl, and 3-7 membered heterocyclyl, each optionally substituted with one or more R 4 ; each R 4  is independently selected from the group consisting of halogen, \u2014CN, \u2014OH, \u2014C(O)R 8 , \u2014SO 2 R 16 , optionally substituted C 1-6  alkyl, optionally substituted C 2-6  alkenyl, optionally substituted C 2-6  alkynyl, optionally substituted C 1-6  alkoxy, optionally substituted C 6-10  aryl optionally substituted with one or more R 11 , C 7-14  aralkyl optionally substituted with one or more R 11 , 5-10 membered heteroaryl optionally substituted with one or more R 11 , or independently two geminal R 4  together are oxo; each R 9  is independently selected from the group consisting of hydroxy, halogen, optionally substituted C 1-6  alkyl, optionally substituted C 2-6  alkenyl, optionally substituted C 2-6  alkynyl, optionally substituted C 1-6  alkylthio, optionally substituted C 2-8  alkoxyalkyl, optionally substituted C 3-10  carbocyclyl, optionally substituted C 6-10  aryl, \u2014OR 5 , \u2014NR 14 R 15 , \u2014C(O)R 8 , \u2014SO 2 R 16 , \u2014CN, and \u2014NO 2 ; or independently, two adjacent R 9  together with the atoms to which they are attached form an optionally substituted fused 5 to 6 membered heteroaryl or an optionally substituted fused 5 to 6 membered heterocyclyl; R 14  is selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 6-10  aryl, and \u2014C(O)R 8 ; R 15  is selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 6-10  aryl, and \u2014C(O)R 8 ; each R 8  is independently selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 2-6  alkenyl, optionally substituted C 2-6  alkynyl, C 6-10  aryl optionally substituted with one or more R 11 , C 7-14  aralkyl optionally substituted with one or more R 11 , \u2014NR 12 R 13 , and \u2014OR 5 ; each R 12  is independently selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 2-6  alkenyl, optionally substituted C 2-6  alkynyl, C 6-10  aryl optionally substituted with one or more R 11 , and C 7-14  aralkyl optionally substituted with one or more R 11 ; each R 13  is independently selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 2-6  alkenyl, optionally substituted C 2-6  alkynyl, C 6-10  aryl optionally substituted with one or more R 11 , and C 7-14  aralkyl optionally substituted with one or more R 11 ; each R 5  is independently selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, optionally substituted C 2-6  alkenyl, optionally substituted C 2-6  alkynyl, optionally substituted C 2-8  alkoxyalkyl, C 6-10  aryl optionally substituted with one or more R 11 , C 7-14  aralkyl optionally substituted with one or more R 11 , and \u2014(CH 2 ) n -(3-10 membered heterocyclyl) optionally substituted with one or more R 10 ; each R 10  is independently selected from the group consisting of optionally substituted C 1-6  alkyl, optionally substituted C 2-6  alkenyl, and optionally substituted C 2-6  alkynyl, or independently two geminal R 10  together are oxo; each R 11  is independently selected from the group consisting of halogen, \u2014CN, optionally substituted C 1-6  alkyl, optionally substituted C 2-6  alkenyl, optionally substituted C 2-6  alkynyl, and optionally substituted C 1-6  alkoxy; each R 16  is independently selected from the group consisting of optionally substituted C 1-6  alkyl, optionally substituted C 2-6  alkenyl, optionally substituted C 2-6  alkynyl, C 6-10  aryl optionally substituted with one or more R 11 , C 7-14  aralkyl optionally substituted with one or more R 11 , \u2014NR 12 R 13 , and \u2014OR 5 ; Z is selected from oxygen and sulfur; each n is independently an integer from 0 to 4; and the bonds represented by a solid and dashed line are independently selected from the group consisting of a single bond and a double bond, provided that when R 3  is phenyl optionally substituted with one or more R 9 , and Z is O; then ring A cannot be optionally substituted phenyl.

Metadata:
- Claim Count in Document: 173.0
- Percentile: 99.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15492828', '15162214', '15128061', '14043121', '13991321']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8490610793670577
- 35 USC 102 Novelty (BERT): 0.5677480512652876
- Combined Prediction Score: 0.8209297765568807
- Mean Citation Score: 437.829976
- Max Citation Score: 458.80676
- Similarity Product: 415.6402095017385

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test