PATENT CLAIM ANALYSIS

Application Number: 15942321
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "210020"]

Abstract:
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Claim (Index 26):
The compound of  claim 25 , wherein D is\n i. (C 6-10  aryl)(C 1-6  alkyl) z -, (C 3-7  cycloalkyl)(C 1-6  alkyl) z -, or (C 3-9  heteroaryl)(C 1-6  alkyl) z -, wherein, said heteroaryl has 1-4 heteroatoms selected from O, S and N; and wherein said aryl, cycloalkyl or heteroaryl can be optionally substituted with one, two, three or four of R 14 , R 15 , R 16\u2032  and R 16 , each of which is independently selected from the group consisting of: a. branched or linear C 1-6  alkyl or C 2-6  alkenyl, wherein said alkyl or alkenyl can be optionally substituted with one to four substituents independently selected from the group consisting of hydroxyl, halogen, \u2014CHF 2 , \u2014CF 3 , amino, di(C 1-6  alkyl)amino, mono(C 1-6  alkyl)amino, cyano C 1-6  alkoxy, \u2014SO 2 R\u2032, \u2014SO 2 NR\u2032R\u2033, \u2014C(O)NR w R x , and \u2014NR w C(O)R x , wherein R w  and R x  are independently H or C 1-6  alkyl; wherein two of R 14 , R 15 , R 16\u2032  and R 16  attached to different atoms are taken together with the atom to which each is attached to form a bicyclic or tricyclic, wherein said bicyclic or tricyclic may be substituted with one, two, three or four of R 14 , R 15 , R 16\u2032  and R 16  as described above; b. C 3-7  cycloalkyl; c. C 3-7  heterocyclyl, wherein said heterocyclyl can be optionally substituted by hydroxyl, acetyl, or oxetane; d. hydroxyl; e. halogen; f. \u2014CHF 2 ; g. \u2014CF 3 ; h. amino; i. di(C 1-6  alkyl)amino; j. mono(C 1-6  alkyl)amino; k. cyano; l. \u2014NR y C(O)R z , wherein R y  and R z  are independently H or C 1-6  alkyl; m. \u2014C(O)NR y R z , wherein R y  and R z  are independently H or C 1-6  alkyl; n. \u2014SO 2 NR y R z , wherein R y  and R z  are independently H or C 1-6  alkyl; and o. \u2014C(O)OR y , wherein R y  is H or C 1-6  alkyl; and, z is 1 or 0; ii. C 3-7  cycloalkyl-SO 2 \u2014, wherein said cycloalkyl can be optionally substituted with one or two of R 6\u2032 , wherein R 6\u2032 , in each instance, is independently selected from the group consisting of branched or linear C 1-6  alkyl, halogen, cyano, \u2014CF 3 , \u2014CHF 2 , hydroxy(C 1-6  alkyl), halo(C 1-6  alkyl), hydroxyl, (C 1-6  alkyl)-O\u2014(C 1-6  alkyl)-, C 1-6  alkoxy, amino, di(C 1-6  alkyl)amino, mono(C 1-6  alkyl)amino, amino(C 1-6  alkyl), and NR e\u2032 R f\u2032 \u2014C(O)\u2014(C 1  alkyl) n -, wherein R e\u2032  and R f\u2032  are independently selected from the group consisting of hydrogen and branched or linear C 1-6  alkyl, and n is 1 or 0; or iii. H, C 1-6  alkyl or pyrrolidine, wherein said alkyl is optionally substituted with halogen.

Metadata:
- Claim Count in Document: 140.0
- Percentile: 90.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12530648', '13102720', '15281923', '13266976', '15852639']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7846561302503022
- 35 USC 102 Novelty (BERT): 0.5145868866906337
- Combined Prediction Score: 0.7576492058943354
- Mean Citation Score: 269.39763800000003
- Max Citation Score: 276.27457000000004
- Similarity Product: 194.8731446854401

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test