PATENT CLAIM ANALYSIS

Application Number: 15884742
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["564", "374000"]

Abstract:
Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.

Claim (Index 30):
The method of  claim 27 , wherein the purifying of step (b) comprises crystallization of 2-(3-(trifluoromethyl)phenyl)acetic acid from the composition.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 86.0
- Lexical Diversity: 2.21212
- Patent Class: 564.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15385525', '14381290', '14381625', '15338984', '14381618']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7091845479722853
- 35 USC 102 Novelty (BERT): 0.5405738346943549
- Combined Prediction Score: 0.6923234766444922
- Mean Citation Score: 195.301222
- Max Citation Score: 328.64047
- Similarity Product: 252.816996694088

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test