PATENT CLAIM ANALYSIS

Application Number: 15920285
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-09
Patent Classification: ["435", "188000"]

Abstract:
Disclosed herein are ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) complexes and synthetic molecules that interact with an ENPP protein. In some embodiments, also disclosed herein are modified ENPP polypeptides in complex with a synthetic molecule described herein.

Claim (Index 18):
The ENPP-molecule complex of  claim 1 , wherein the synthetic molecule has a structure represented by Formula (III), or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof: wherein Y is \u2014O\u2014 or \u2014NR 20 \u2014; L 2  is a bond or \u2014(CR 21 R 22 ) n2 \u2014; W 1  and W 2  are independently N or CR a ; provided that at least one of W 1  or W 2  is N; Ring C is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; each R 23  is independently hydrogen, halogen, \u2014CN, \u2014OR 11 , \u2014SR 11 , \u2014S(\u2550O)R 10 , \u2014NO 2 , \u2014NR 11 R 12 , \u2014S(\u2550O) 2 R 10 , \u2014NR 11 S(\u2550O) 2 R 10 , \u2014S(\u2550O) 2 NR 11 R 12 , \u2014C(\u2550O)R 10 , \u2014OC(\u2550O)R 10 , \u2014C(\u2550O)OR 11 , \u2014OC(\u2550O)OR 11 , \u2014C(\u2550O)NR 11 R 12 , \u2014OC(\u2550O)NR 11 R 12 , \u2014NR 11 C(\u2550O)NR 11 R 12 , \u2014NR 11 C(\u2550O)R 10 , \u2014NR 11 C(\u2550O)OR 11 , optionally substituted C 1 -C 6  alkyl, optionally substituted C 1 -C 6  heteroalkyl, optionally substituted C 2 -C 6  alkenyl, optionally substituted C 2 -C 6  alkynyl, optionally substituted cycloalkyl, optionally substituted (C 1 -C 6  alkyl)cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted (C 1 -C 6  alkyl)heterocycloalkyl, optionally substituted aryl, optionally substituted (C 1 -C 6  alkyl)aryl, optionally substituted heteroaryl, or optionally substituted (C 1 -C 6  alkyl)heteroaryl; R 2c  is hydrogen, \u2014SR 11 , \u2014S(\u2550O)R 10 , \u2014S(\u2550O) 2 R 10 , \u2014S(\u2550O) 2 NR 11 R 12 , \u2014C(\u2550O)R 10 , \u2014C(\u2550O)NR 11 R 12 , optionally substituted C 1 -C 6  alkyl, optionally substituted C 1 -C 6  heteroalkyl, optionally substituted C 2 -C 6  alkenyl, optionally substituted C 2 -C 6  alkynyl, optionally substituted cycloalkyl, optionally substituted (C 1 -C 6  alkyl)cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted (C 1 -C 6  alkyl)heterocycloalkyl, optionally substituted aryl, optionally substituted (C 1 -C 6  alkyl)aryl, optionally substituted heteroaryl, or optionally substituted (C 1 -C 6  alkyl)heteroaryl; R 20  is hydrogen, \u2014SR 11 , \u2014S(\u2550O)R 10 , \u2014S(\u2550O) 2 R 10 , \u2014S(\u2550O) 2 NR 11 R 12 , \u2014C(\u2550O)R 10 , \u2014C(\u2550O)NR 11 R 12 , optionally substituted C 1 -C 6  alkyl, optionally substituted C 1 -C 6  heteroalkyl, optionally substituted C 2 -C 6  alkenyl, optionally substituted C 2 -C 6  alkynyl, optionally substituted cycloalkyl, optionally substituted (C 1 -C 6  alkyl)cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted (C 1 -C 6  alkyl)heterocycloalkyl, optionally substituted aryl, optionally substituted (C 1 -C 6  alkyl)aryl, optionally substituted heteroaryl, or optionally substituted (C 1 -C 6  alkyl)heteroaryl; each R 21  and R 22  are independently hydrogen, halogen, \u2014CN, \u2014OR 11 , \u2014SR 11 , \u2014S(\u2550O)R 10 , \u2014NO 2 , \u2014NR 11 R 12 , \u2014S(\u2550O) 2 R 10 , \u2014NR 11 S(\u2550O) 2 R 10 , \u2014S(\u2550O) 2 NR 11 R 12 , \u2014C(\u2550O)R 10 , \u2014OC(\u2550O)R 10 , \u2014C(\u2550O)OR 11 , \u2014OC(\u2550O)OR 11 , \u2014C(\u2550O)NR 11 R 12 , \u2014OC(\u2550O)NR 11 R 12 , \u2014NR 11 C(\u2550O)NR 11 R 12 , \u2014NR 11 C(\u2550O)R 10 , \u2014NR 11 C(\u2550O)OR 11 , optionally substituted C 1 -C 6  alkyl, optionally substituted C 1 -C 6  heteroalkyl, optionally substituted C 2 -C 6  alkenyl, or optionally substituted C 2 -C 6  alkynyl; or R 21  and R 22  on the same carbon are taken together to form an oxo; each R a  is independently hydrogen, halogen, \u2014CN, \u2014OR 11 , \u2014SR 11 , \u2014S(\u2550O)R 10 , \u2014NO 2 , \u2014NR 11 R 12 , \u2014S(\u2550O) 2 R 10 , \u2014NR 11 S(\u2550O) 2 R 10 , \u2014S(\u2550O) 2 NR 11 R 12 , \u2014C(\u2550O)R 10 , \u2014OC(\u2550O)R 10 , \u2014C(\u2550O)OR 11 , \u2014OC(\u2550O)OR 11 , \u2014C(\u2550O)NR 11 R 12 , \u2014OC(\u2550O)NR 11 R 12 , \u2014NR 11 C(\u2550O)NR 11 R 12 , \u2014NR 11 C(\u2550O)R 10 , \u2014NR 11 C(\u2550O)OR 11 , optionally substituted C 1 -C 6  alkyl, optionally substituted C 1 -C 6  heteroalkyl, optionally substituted C 2 -C 6  alkenyl, optionally substituted C 2 -C 6  alkynyl, optionally substituted cycloalkyl, optionally substituted (C 1 -C 6  alkyl)cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted (C 1 -C 6  alkyl)heterocycloalkyl, optionally substituted aryl, optionally substituted (C 1 -C 6  alkyl)aryl, optionally substituted heteroaryl, or optionally substituted (C 1 -C 6  alkyl)heteroaryl; each R 10  is optionally substituted C 1 -C 6  alkyl, optionally substituted C 2 -C 6  alkenyl, optionally substituted C 2 -C 6  alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; each R 11  and R 12  are each independently hydrogen, optionally substituted C 1 -C 6  alkyl, optionally substituted C 2 -C 6  alkenyl, optionally substituted C 2 -C 6  alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or R 11  and R 12  are taken together with the nitrogen atom to which they are attached to form an optionally substituted heterocycloalkyl;\n t is 1-4; \n n2 is 1 or 2; and \n u is 1-4.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.25806
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13059195', '11687565', '14679866', '12567258', '13093729']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6824362941433726
- 35 USC 102 Novelty (BERT): 0.5247181572540506
- Combined Prediction Score: 0.6666644804544404
- Mean Citation Score: 344.90997600000014
- Max Citation Score: 351.1761
- Similarity Product: 273.67123271030187

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test