PATENT CLAIM ANALYSIS

Application Number: 15977276
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "289000"]

Abstract:
This disclosure relates to methods administering various compounds in conjunction with dextromethorphan to a human being. Dosage forms, drug delivery systems, and methods related to dextromethorphan or dextrorphan and bupropion, hydroxybupropion, erythrohydroxybupropion, threohydroxybupropion, or a metabolite or prodrug of any of these compounds are also disclosed

Claim (Index 1):
A method of enhancing dextromethorphan plasma levels in a human being, comprising co-administering a bupropion with a dextromethorphan, to the human being, for at least 14 consecutive days, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, and the human being is not suffering from neuropathic pain, wherein the bupropion and the dextromethorphan, are the sole active agents administered to the human being, wherein the bupropion is administered in an amount that, on the eighth day that the bupropion and the dextromethorphan are co-administered, results in: 1) a C max  of dextromethorphan that is at least about 40 ng/mL, 2) an AUC 0-12  of dextromethorphan that is at least about 450 ng\u00b7hr/mL, 3) a C max  of bupropion that is at least about 50 ng/mL, 4) a C max  of hydroxybupropion that is at least about 300 ng/mL, 5) a C max  of erythrohydroxybupopropion that is at least about 30 ng/mL, and 6) a C max  of threohydroxybupropion that is at least about 100 ng/mL, and wherein, on the eighth day that the bupropion and the dextromethorphan are co-administered, the C max  of dextromethorphan is at least about 15 times the C max  of dextromethorphan that would result from administering the same amount of the dextromethorphan without the bupropion for eight consecutive days.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 93.0
- Lexical Diversity: 1.39474
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15206057', '15688660', '15691532', '15933075', '15182253']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8719542492162998
- 35 USC 102 Novelty (BERT): 0.6660991820067216
- Combined Prediction Score: 0.851368742495342
- Mean Citation Score: 730.4778859999999
- Max Citation Score: 733.5992
- Similarity Product: 623.0823314321041

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test