PATENT CLAIM ANALYSIS

Application Number: 16079499
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["435", "171000"]

Abstract:
The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

Claim (Index 28):
A recombinant host cell, comprising a recombinant gene encoding damage resistance protein 1 (DAP1) polypeptide having at least 60% sequence identity to the amino acid sequence set forth in SEQ ID NO:2, wherein the recombinant host cell is capable of producing one or more steviol glycosides or a steviol glycoside composition in a cell culture, and further comprising:\n (a) a gene encoding a polypeptide capable of synthesizing geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP);\n wherein the polypeptide comprises a polypeptide having at least 70% sequence identity to the amino acid sequence set forth in SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, or SEQ ID NO:116; \n (b) a gene encoding a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP;\n wherein the polypeptide comprises a polypeptide having at least 70% sequence identity to one of the amino acid sequences set forth in SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, SEQ ID NO:40, or SEQ ID NO:42; \n (c) a gene encoding a polypeptide capable of synthesizing ent-kaurene from ent-copalyl pyrophosphate;\n wherein the polypeptide comprises a polypeptide having at least 70% sequence identity to one of the amino acid sequences set forth in SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, or SEQ ID NO:52; \n (d) a gene encoding a polypeptide capable of synthesizing ent-kaurenoic acid, ent-kaurenol, and/or ent-kaurenal from ent-kaurene;\n wherein the polypeptide comprises a polypeptide having at least 70% sequence identity to one of the amino acid sequences set forth in SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:117, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:70, SEQ ID NO:72, SEQ ID NO:74, or SEQ ID NO:76; \n (e) a gene encoding a polypeptide capable of synthesizing steviol from ent-kaurenoic acid;\n wherein the polypeptide comprises a polypeptide having at least 70% sequence identity to one of the amino acid sequences set forth in SEQ ID NO:94, SEQ ID NO:97, SEQ ID NO:100, SEQ ID NO:101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID NO:106, SEQ ID NO:108, SEQ ID NO:110, SEQ ID NO:112, or SEQ ID NO:114; and \n (f) a gene encoding a polypeptide capable of reducing cytochrome P450 complex;\n wherein the polypeptide comprises a polypeptide having at least 70% sequence identity to one of the amino acid sequences set forth in SEQ ID NO:78, SEQ ID NO:80, SEQ ID NO:82, SEQ ID NO:84, SEQ ID NO:86, SEQ ID NO:88, SEQ ID NO:90, SEQ ID NO:92; \n wherein expression of the recombinant gene encoding DAP1 polypeptide results in increased production of the one or more steviol glycosides or the steviol glycoside composition in the cell culture.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 96.0
- Lexical Diversity: 1.13333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15506196', '15541686', '14761629', '15382354', '14237540']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7184919779474971
- 35 USC 102 Novelty (BERT): 0.6460711189456613
- Combined Prediction Score: 0.7112498920473135
- Mean Citation Score: 585.9904920000001
- Max Citation Score: 643.51636
- Similarity Product: 521.6315502787637

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test