PATENT CLAIM ANALYSIS

Application Number: 15919866
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "186100"]

Abstract:
Methods for generating antibodies to immuno-subdominant epitopes of elusive pathogens and vaccines and methods of vaccinating subjects against elusive pathogens are disclosed. The methods include targeting immunodominant B cells to undergo apoptosis, for example, while simultaneously targeting the germinal center (GC) reaction toward preferential selection and differentiation of B cells that produce broadly neutralizing antibody against a targeted pathogen.

Claim (Index 1):
A method of immunizing a mammalian subject against a pathogen comprising the steps of:\n (1) administering a primary immunization composition to the subject, said primary immunization composition comprising a peptide expressed by the pathogen, wherein said peptide comprises a neutralizing epitope; and (2) administering to the subject a composition comprising an inhibitory construct comprising at least one copy of an altered form of the peptide, wherein the altered form comprises at least one amino acid change or structural alteration of the neutralizing epitope that prevents binding of neutralizing antibody thereto; and wherein the inhibitory construct is administered prior to, concurrently with or within two months of administration of the primary immunization composition.

Metadata:
- Claim Count in Document: 45.0
- Percentile: 90.0
- Lexical Diversity: 1.3
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13989176', '13262285', '14777605', '11962007', '15512820']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7548978913059474
- 35 USC 102 Novelty (BERT): 0.5207923737761606
- Combined Prediction Score: 0.7314873395529689
- Mean Citation Score: 315.343366
- Max Citation Score: 333.24872
- Similarity Product: 248.507583436718

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test