PATENT CLAIM ANALYSIS

Application Number: 15752308
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "009420"]

Abstract:
Nanoparticles and nanoprobes for use as a contrast agent for X-ray imaging techniques, CT scanning techniques, MRI and optical imaging are disclosed. The nanoparticles and nanoprobes include a core having a contrast element characterized by a K-edge value ranging from about 17 to about 49 keV, and a stabilizing element which minimizes one or both of cytotoxicity and immunoreactivity of the contrast element. A first coating layer encapsulates the core, the first coating layer configured to render the nanoparticles soluble in a biological medium. A method for dual energy x-ray imaging includes the steps of administering to a subject the nanoparticles disclosed herein as a contrast agent; acquiring an image with a low energy spectrum; and acquiring an image with a high energy spectrum.

Claim (Index 4):
The nanoparticles of  claim 3 , wherein the first coating layer is comprised of one or more first coating layer components selected from the group consisting of lipoic acid, oleic acid, glutathione, dodecanethiol, natural phospholipids, polyethylene glycol modified phospholipids, 11-mercapto-undecanoic acid, thioglucose, lecithin, dimyristoyl phosphatidylcholine, albumin, apolipoprotein AI thio-polyethylene glycol, polyacrylic acid, poly(D,L-lactic-co-glycolic acid), polycaprolactone, poly(vinyl-pyrrolidone), poly(acryl-amide), and poly(glycerol).

Metadata:
- Claim Count in Document: 50.0
- Percentile: 88.0
- Lexical Diversity: 1.78667
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12843664', '12675633', '13729815', '13580594', '15390106']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6942332641732285
- 35 USC 102 Novelty (BERT): 0.4822688834947129
- Combined Prediction Score: 0.673036826105377
- Mean Citation Score: 166.35510599999995
- Max Citation Score: 168.94603999999995
- Similarity Product: 116.08506854307171

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test