PATENT CLAIM ANALYSIS

Application Number: 16060410
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-05
Patent Classification: ["424", "205100"]

Abstract:
Disclosed are therapeutic compositions and methods for inducing an immune response to human papillomavirus (HPV). More particularly, disclosed is a method for inducing an immune response in a subject by introducing and expressing a nucleic acid molecule encoding an immunogenic HPV antigen.

Claim (Index 1):
A construct system for the treatment of human papillomavirus (HPV) infection in a subject, wherein the system comprises a first nucleic acid construct and a second nucleic acid construct,\n wherein the first construct comprises a first synthetic coding sequence that encodes a first polypeptide sequence comprising an HPV E6 amino acid sequence conjugated to a HPV E7 amino acid sequence, wherein the HPV E6 and E7 amino acid sequences are both distinguished from a wild-type HPV E6 and E7 coding sequences, respectively, by the replacement of selected codons in the wild-type HPV E6 or E7 coding sequence with synonymous codons, wherein an individual synonymous codon has a preference for producing a greater immune response than a corresponding selected codon, wherein the codon replacements are selected from TABLE 1, wherein at least about 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, of the codons for the first synthetic coding sequence are synonymous codons according to TABLE 1, and wherein the first synthetic coding sequence is operably connected to a regulatory nucleic acid sequence; and wherein the second construct comprises a second synthetic coding sequence that encodes a first polypeptide sequence comprising an HPV E6 amino acid sequence conjugated to a HPV E7 amino acid sequence, wherein the HPV E6 and E7 amino acid sequences are both distinguished from a wild-type HPV E6 and E7 coding sequences, respectively, by the replacement of selected codons in the wild-type HPV E6 or E7 coding sequence with synonymous codons, wherein an individual synonymous codon has a preference for producing a greater immune response than a corresponding selected codon, wherein the codon replacements are selected from TABLE 1, and wherein at least about 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100%, of the codons for the first synthetic coding sequence are synonymous codons according to TABLE 1, and wherein the first synthetic coding sequence is operably connected to a regulatory nucleic acid sequence; and to a nucleic acid sequence that encodes a ubiquitin molecule; and wherein TABLE 1 is as follows: TABLE 1 Synonymous First Codon Codon Ala GCG Ala GCT Ala GCG Ala GCC Ala GCA Ala GCT Ala GCA Ala GCC Ala GCC Ala GCT Arg CGG Arg CGA Arg CGG Arg CGC Arg CGG Arg CGT Arg CGG Arg AGA Arg AGG Arg CGA Arg AGG Arg CGC Arg AGG Arg CGT Arg AGG Arg AGA Asn AAT Asn AAC Asp GAT Asp GAC Cys TGT Cys TGC Glu GAG Glu GAA Gly GGC Gly GGA Gly GGT Gly GGA Gly GGG Gly GGA Ile ATA Ile ATC Ile ATA Ile ATT Ile ATT Ile ATC Leu TTA Leu CTG Leu TTA Leu CTC Leu TTA Leu CTA Leu TTA Leu CTT Leu TTA Leu TTG Leu TTG Leu CTG Leu TTG Leu CTC Leu TTG Leu CTA Leu TTG Leu CTT Leu CTT Leu CTG Leu CTT Leu CTC Leu CTA Leu CTG Leu CTA Leu CTC Phe TTC Phe TTT Pro CCG Pro CCC Pro CCG Pro CCT Pro CCA Pro CCC Pro CCA Pro CCT Pro CCT Pro CCC Ser AGT Ser TCG Ser AGT Ser TCT Ser AGT Ser TCA Ser AGT Ser TCC Ser AGC Ser TCG Ser AGC Ser TCT Ser AGC Ser TCA Ser AGC Ser TCC Ser TCC Ser TCG Ser TCA Ser TCG Ser TCT Ser TCG Thr ACT Thr ACG Thr ACT Thr ACC Thr ACT Thr ACA Thr ACA Thr ACG Thr ACA Thr ACC Thr ACC Thr ACG Tyr TAT Tyr TAC Val GTA Val GTG Val GTA Val GTC Val GTA Val GTT Val GTT Val GTG Val GTT Val GTC

Metadata:
- Claim Count in Document: 28.0
- Percentile: 94.0
- Lexical Diversity: 1.30556
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13090932', '12738284', '11077939', '10305765', '10612818']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8003467504933545
- 35 USC 102 Novelty (BERT): 0.5777027920949508
- Combined Prediction Score: 0.778082354653514
- Mean Citation Score: 457.712446
- Max Citation Score: 579.3969999999998
- Similarity Product: 373.7999118667244

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test