PATENT CLAIM ANALYSIS

Application Number: 15760387
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "211040"]

Abstract:
The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Claim (Index 1):
A compound represented by: wherein Y is S(O) y , wherein y is 2; R Z  is H; R m\u2032  and R m  are each H; R 21  is selected for each occurrence from the group consisting of H, halogen, and C 1-6 alkyl; q is 0, 1, or 2; R 22  is selected for each occurrence from the group consisting of H, halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, \u2014C(O)\u2014NR\u2032R\u2033, \u2014C(\u2550NH)\u2014NR\u2032R\u2033, X 2 -phenyl (optionally substituted by one, two or three substituents represented by R 63 ), phenyl (optionally substituted by one, two or three substituents represented by R 63 ), 5-6 membered monocyclic heteroaryl (optionally substituted by one, two or three substituents represented by R 63 ), 9-10 membered bicyclic heteroaryl (optionally substituted by one, two or three substituents represented by R 73 ), C 3-6 cycloalkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2), and \u2014NR\u2032\u2014S(O) w , (where w is 0, 1 or 2); R\u2032 is selected, independently for each occurrence, from H, methyl, ethyl, and propyl; R\u2033 is selected, independently for each occurrence, from H, methyl, ethyl, propyl, butyl, \u2014C(O)-methyl and \u2014C(O)-ethyl, or R\u2032 and R\u2033 taken together with the nitrogen to which they are attached may form a 4-7 membered heterocycle; each of moieties R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10  is independently selected for each occurrence from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkynyl, C 2-6 alkenyl, halogen, hydroxyl, nitro, cyano, and NR\u2032R\u2033; R 63  is selected independently at each occurrence from the group consisting of H, halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, \u2014C(O)\u2014O\u2014C 1-6 alkyl, heterocycle (optionally substituted by halogen or NR\u2032R\u2032), \u2014C(O)\u2014NR\u2032R\u2033, \u2014C(\u2550NH)\u2014NR\u2032R\u2033, heteroaryl, phenyl, benzyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, carboxy, NR\u2032R\u2033, \u2014C(O)\u2014C  1-6  alkyl, \u2014C(O)\u2014C 1-6 alkoxy, C 3-6 cycloalkyl , \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2), \u2014NR\u2032\u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), X 2 \u2014R 69 ; R 69  is selected from the group consisting of H, halogen, hydroxyl, nitro, cyano, C 1-6 alkyl, \u2014C(O)\u2014O\u2014C 1-6 alkyl, heterocycle (optionally substituted by halogen or NR\u2032R\u2032),), \u2014C(O)\u2014NR\u2032R\u2033, \u2014C(\u2550NH)\u2014NR\u2032R\u2033, heteroaryl, phenyl , C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, carboxy, NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, C 3-6 cycloalkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2), and \u2014NR\u2032\u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), X 2  is selected from S(O) w  (wherein w is 0, 1, or 2), O, CH 2 , or NR\u2032;\n wherein for each occurrence, C 1-6 alkyl may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, \u2014NR\u2032\u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), and S(O) w \u2014NR\u2032R\u2033(where w is 0, 1 or 2); C 1-6 alkoxy may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 1-6  alkyl, NR\u2032R\u2033, \u2014NR\u2032\u2014S(O) w \u2014C 1-6  alkyl (where w is 0,1 or 2), and S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2); \n and pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 90.0
- Lexical Diversity: 1.17949
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15760343', '15125911', '15030378', '15566633', '15539392']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8275874846998171
- 35 USC 102 Novelty (BERT): 0.5494670335735454
- Combined Prediction Score: 0.79977543958719
- Mean Citation Score: 359.835372
- Max Citation Score: 410.44235
- Similarity Product: 312.85926793918605

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test