PATENT CLAIM ANALYSIS

Application Number: 16078303
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["424", "078170"]

Abstract:
Provided is a pharmaceutical preparation including a polymerized camptothecin derivative obtained by bonding a camptothecin derivative to a polymer carrier, the polymerized camptothecin derivative being capable of associating in an aqueous solution and having a nanoparticle-forming property, and the pharmaceutical preparation is a pharmaceutical preparation composition having enhanced preparation stability. Particularly, a pharmaceutical preparation having an excellent associated aggregate-forming property, which is an important factor, and excellent storage stability against chemical stability is provided. Disclosed is a pharmaceutical preparation including a block copolymer in which a polyethylene glycol segment and a polyglutamic acid segment containing a glutamic acid unit having a camptothecin derivative bonded thereto, and a pharmaceutical preparation including one or more additives selected from the group consisting of arginine, histidine, and sodium chloride.

Claim (Index 1):
A pharmaceutical preparation comprising:\n a block copolymer of a polyethylene glycol segment and a polyglutamic acid segment linked together, the polyglutamic acid segment comprising a glutamic acid unit having a camptothecin derivative bonded thereto; and one or more additives selected from the group consisting of arginine, histidine, and sodium chloride, wherein the block copolymer is a block copolymer represented by General Formula (1): wherein R 1  represents a hydrogen atom or an optionally substituted (C1-C6) alkyl group; A represents a (C1-C6) alkylene group; R 2  represents any one selected from the group consisting of a hydrogen atom, an optionally substituted (C1-C6) acyl group, and an optionally substituted (C1-C6) alkoxycarbonyl group; R 3  represents a hydrogen group and/or \u2014N(R 6 )CONH(R 7 );\n R 6  and R 7 , which may be identical or different, each represent a (C1-C8) alkyl group which may be substituted with a tertiary amino group; \n R 4  represents any one selected from the group consisting of a hydrogen atom, an optionally substituted (C1-C6) alkyl group, and an optionally substituted silyl group; R 5  represents a hydrogen atom or an optionally substituted (C1-C6) alkyl group; t represents an integer from 45 to 450; d and e each represent an integer; d+e represents an integer from 6 to 60; the proportion of d with respect to d+e is 1% to 100%; the proportion of e is 0% to 99%; and the polyglutamic acid segment has a polyglutamic acid segment structure in which glutamic acid units having a camptothecin derivative bonded thereto and glutamic acid units having a R 3  group bonded thereto are each independently arranged randomly.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 96.0
- Lexical Diversity: 1.97101
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15752923', '15515295', '15822817', '15548259', '10532670']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7576899232219247
- 35 USC 102 Novelty (BERT): 0.5457408627288681
- Combined Prediction Score: 0.7364950171726191
- Mean Citation Score: 343.73904
- Max Citation Score: 401.48547
- Similarity Product: 371.19169096665854

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test