PATENT CLAIM ANALYSIS

Application Number: 15988914
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-01
Patent Classification: ["424", "425000"]

Abstract:
This disclosure provides a product comprised of a collagen gel to which recombinant human Amelotin (AMTN) protein is added. This AMTN-collagen gel is applied to one side of a physiologically acceptable scaffold that has first been impregnated with AMTN-free collagen gel. The resulting two-layer collagen membrane (layer 1 comprised of scaffold surrounded by collagen gel; layer 2 comprised of collagen gel containing AMTN) is applied to a mineralized tissue surface such as dentin and bone with the collagen gel containing AMTN of layer 2 facing this mineral surface. Upon immersion in simulated body fluid (SBF), the presence of AMTN in layer 2 triggers the formation of hydroxyapatite mineral deposits that intimately connect with the existing mineral surface and thus provide physical attachment. A similar product is disclosed but in addition to AMTN, it contains the Odontogenic, Ameloblast-Associated (ODAM) protein as well with both proteins exhibiting a synergistic effect.

Claim (Index 10):
A device for in vitro induction of biomineralization, comprising:\n a) a physiologically acceptable porous scaffold; b) said porous scaffold being impregnated with a first layer of collagen gel; c) a second layer located on top of the first layer, said second layer including a mixture of collagen, Amelotin (AMTN) protein and Odontogenic, Ameloblast-Associated (ODAM) protein; and d) wherein in use said device is configured to be applied with said second layer with the mixture of collagen gel containing AMTN and ODAM proteins in physical contact with a mineralized surface, the device being characterized in that a presence of AMTN and ODAM proteins in the second layer triggers the formation of hydroxyapatite mineral deposits that intimately connect the second layer with the mineralized surface and thus provide physical attachment.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 93.0
- Lexical Diversity: 1.75532
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12296988', '12576058', '12806912', '10418843', '11433725']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6947141366049285
- 35 USC 102 Novelty (BERT): 0.5053100118286177
- Combined Prediction Score: 0.6757737241272975
- Mean Citation Score: 251.1246
- Max Citation Score: 262.51343
- Similarity Product: 201.06896040336608

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test