PATENT CLAIM ANALYSIS

Application Number: 15756366
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "322000"]

Abstract:
The invention relates to antibacterial compounds of formula I wherein M is one of the groups M A , M B  and M C  represented below wherein R 1 , M A , M B  and M C  are as defined in the specification;and to salts thereof.

Claim (Index 14):
A compound of formula I according to  claim 1 , which is selected from the following:\n (2R)-4-(6-((1-cyclohexylazetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-(((3R)-3-fluoro-1-methylpyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-(((3S)-3-fluoro-1-methylpyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-((1-cyclopentylazetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(3-oxo-6-((1-(tetrahydro-2H-pyran-4-yl)azetidin-3-yl)buta-1,3-diyn-1-yl)-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(3-oxo-6-((1-(thietan-3-yl)azetidin-3-yl)buta-1,3-diyn-1-yl)-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)butanamide; (2R)-4-(6-((1-cyclopropyl-3-fluoropyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-((3-fluoro-1-(2-hydroxyethyl)pyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-((3-fluoropyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-((3-ethyl-1-methylazetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-((1,3-dimethylpyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-4-(6-((1-methylpyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-(methylsulfonyl)butanamide; (2R)-4-(6-(2-fluoro-4-((1-methylazetidin-3-yl)ethynyl)phenyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-4-(6-(4-((1-methylazetidin-3-yl)ethynyl)phenyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-(methylsulfonyl)butanamide; (2R)-2-(3-((4-(6-((1-(2-hydroxyethyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanam ido)oxy)-3-oxopropyl)phenyl dihydrogen phosphate; (2R)-4-(6-(2-fluoro-4-((1-methylpiperidin-4-yl)ethynyl)phenyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-(2-fluoro-4-((1-(2-hydroxyethyl)azetidin-3-yl)ethynyl)phenyl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(6-((1-(oxetan-3-yl)pyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)butanamide; (2R)\u2014N-hydroxy-4-(6-((1-((r,3r)-3-hydroxycyclobutyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(6-((1-((1s,3s)-3-hydroxycyclobutyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-(((2S,3R)-1,2-dimethylazetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-(((2R,3S)-1,2-dimethylazetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(6-(((3R,5R)-5-(hydroxymethyl)-1-methylpyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(6-(((2R,3R)-2-(hydroxymethyl)-1-methylazetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(6-(((2R,3R)-1,2-dimethylazetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(6-(((2S,3S)-2-(hydroxymethyl)-1-methylazetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(6-(((2S,3S)-2-(fluoromethyl)-1-methylazetidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(6-(((3S*,4R*)-4-hydroxy-1-m ethylpyrrol id in-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanamide; and (2R)\u2014N-hydroxy-4-(6-(((3R,5R)-5-(hydroxymethyl)-1-(oxetan-3-yl)pyrrolidin-3-yl)buta-1,3-diyn-1-yl)-3-oxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-2-methyl-2-(methylsulfonyl)butanamide; or a salt of this compound.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.51515
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15123184', '15021649', '15311758', '15106790', '15751596']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8314473639132505
- 35 USC 102 Novelty (BERT): 0.6424862820060245
- Combined Prediction Score: 0.8125512557225278
- Mean Citation Score: 564.289124
- Max Citation Score: 663.8811599999998
- Similarity Product: 544.9240278149341

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test