PATENT CLAIM ANALYSIS

Application Number: 15778785
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["549", "359000"]

Abstract:
The present disclosure discloses a modified compound of andrographolide, and particularly discloses a compound shown in formula (I) and (II) or a pharmaceutically acceptable salt thereof.

Claim (Index 1):
A compound represented by formula (I) and (II), pharmaceutically acceptable salt or tautomer thereof, wherein, W is O, N(R 5 ) or a ring R 5  is H, or a C 1-3  alkyl optionally substituted by 1, 2 or 3 halogen, OH, NH 2 , COOH, NHMe or N(Me) 2 ; L 1  and L 4  are selected from a single bond and \u2014(CRR) 1-3 \u2014; R 1 , R 4  are selected from H, COOH, or are each independently selected from the group consisting of NH 2 , a C 1-6  alkyl, a C 1-6  heteroalkyl, a 5-10 membered aryl and a 5-10 membered heteroaryl, which are optionally substituted with 1, 2, or 3 R or R\u2032; R 2 , R 3  are each independently selected from H, or are each independently selected from the group consisting of a C 1-6  alkyl, a C 1-6  heteroalkyl, a C 3-6  cycloalkyl and a 3-6 membered heterocycloalkyl, a 5-6 membered aryl or heteroaryl, which are optionally substituted with 1, 2, or 3 R or R\u2032; optionally, R 2  and R 3  can be linked together to form a 4-7 membered ring; the ring A is selected from a 4-10 membered ring which is optionally substituted with 1, 2 or 3R\u2032; R is independently selected from F, Cl, Br, I, OH, NH 2 , CN, C(\u2550O)OH, or from the group consisting of a C 1-6  alkyl, a C 1-6  heteroalkyl, a -L-C 3-6  cycloalkyl, and a -L-3-6 membered heterocycloalkyl, which is optionally substituted with 1, 2 or 3 R\u2032; L is a single bond, \u2014O\u2014, \u2014S\u2014, \u2014C(\u2550O)NH\u2014, \u2014NH\u2014, \u2014C(\u2550O)O\u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 ; R\u2032 is independently selected from halogen, CN, OH, N(CH 3 ) 2 , NH(CH 3 ), NH 2 , CHO, C(\u2550O)OH, C(\u2550O)NH 2 , S(\u2550O)NH 2 , S(\u2550O) 2 NH 2 , trihalomethyl, dihalomethyl, monohalomethyl, aminomethyl, hydroxymethyl, methyl, methoxy, formyl, methoxycarbonyl, Boc, methylsulfonyl, methylsulfinyl, ethyl, n-propyl, isopropyl, C 3-6  membered cycloalkyl, and 3-6 membered heterocycloalkyl; \u201chetero\u201d refers to a heteroatom or a heteroatomic group selected from the group consisting of \u2014C(\u2550O)N(R)\u2014, \u2014N(R)\u2014, \u2014C(\u2550NR)\u2014, \u2014S(\u2550O) 2 N(R)\u2014, \u2014S(\u2550O)N(R)\u2014, \u2014O\u2014, \u2014S\u2014, \u2550O, \u2550S, \u2014C(\u2550O)O\u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 \u2014 and \u2014N(R)C(\u2550O)N(R)\u2014; in any of the above cases, the number of heteroatom or heteroatom group is independently selected from 1, 2 or 3.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 1.28
- Patent Class: 549.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15910571', '13058227', '15575037', '11727927', '15517951']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7727837032727823
- 35 USC 102 Novelty (BERT): 0.5353492357136214
- Combined Prediction Score: 0.7490402565168662
- Mean Citation Score: 352.99469000000005
- Max Citation Score: 361.08292
- Similarity Product: 301.43906117232086

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test