PATENT CLAIM ANALYSIS

Application Number: 16057021
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["540", "529000"]

Abstract:
The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine (PL) or derivative thereof. The selective killing of senescent cells may delay aging and/or treat age-related disorders.

Claim (Index 14):
A method of killing therapy-induced senescent cells, the method comprising administering a composition comprising a therapeutically effective amount of a compound comprising formula (II) to a subject that has received DNA-damaging therapy and killing therapy induced-senescent cells in normal and tumor tissues following DNA-damaging therapy: wherein:\n X is selected from the group consisting of C(O), C(S), C(NH) and S(O) 2 ; \n Y is selected from the group consisting of O, NH and S; \n n is 1; \n R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8  are each independently selected from the group consisting of hydrogen, deuterium, halogen, CF 3 , CN, OH, OCH 3 , OR, SR, NRR, NRCOR, NRCONRR, NRCO 2 R, COR, CO 2 R, NOR, NO 2 , CONRR, OC(O)NRR, SO 2 R, SO 2 NRR, NRSO 2 R, NRSO 2 NRR, C(O)C(O)R, and C(O)CH 2 C(O)R, a substituted or unsubstituted C1 to C6 alkyl, a substituted or unsubstituted C1 to C6 alkenyl, a substituted or unsubstituted C1 to C6 alkynyl, and a substituted or unsubstituted aryl; \n R is independently selected from the group consisting of hydrogen, substituted C1-C4 aliphatic moiety, aliphatic moiety containing nitrogen, oxygen, or sulfur, or alternately, two R moieties bound to the same nitrogen atom are optionally taken together with the nitrogen atom to form a 3-7 membered saturated or unsaturated ring having 1-2 additional heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur; \n A is selected from the group consisting of \n wherein:\n R 9  and R 10  are independently selected from the group consisting of hydrogen, deuterium, halogen, CF 3 , CN, OH, OCH 3 , OR\u2032, SR\u2032, NR\u2032R\u2032, NR\u2032COR\u2032, NR\u2032CONR\u2032R\u2032, NR\u2032CO 2 R\u2032, COR\u2032, CO 2 R\u2032, NOR\u2032, NO 2 , CONR\u2032R\u2032, OC(O)NR\u2032R\u2032, SO 2 R, SO 2 NR\u2032R\u2032, NR\u2032SO 2 R\u2032, NR\u2032SO 2 NR\u2032R\u2032, C(O)C(O)R\u2032, and C(O)CH 2 C(O)R\u2032, a substituted or unsubstituted C1 to C6 alkyl, a substituted or unsubstituted C1 to C6 alkenyl, a substituted or unsubstituted C1 to C6 alkynyl, and a substituted or unsubstituted aryl; \n R\u2032 is independently selected from the group consisting of hydrogen, substituted C1-C4 aliphatic moiety, aliphatic moiety containing nitrogen, oxygen, or sulfur, or alternately, two R\u2032 moieties bound to the same nitrogen atom are optionally taken together with the nitrogen atom to form a 3-7 membered saturated or unsaturated ring having 1-2 additional heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur; \n Optionally, R 9  and R 10  are taken together to form a 5-8 membered saturated or unsaturated ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur; \n B is \n wherein:\n R 11 , R 12 , R 13 , R 14 , and R 15  are each independently selected from the group consisting of hydrogen, deuterium, halogen, CF 3 , CN, OH, OCH 3 , OR\u2033, SR\u2033, NR\u2033R\u2033, NR\u2033COR\u2033, NR\u2033CONR\u2033R\u2033, NRCO 2 R\u2033, COR\u2033, CO 2 R\u2033, NOR\u2033, NO 2 , CONR\u2033R\u2033, OC(O)NR\u2033R\u2033, SO 2 R\u2033, SO 2 NR\u2033R\u2033, NR\u2033SO 2 R\u2033, NR\u2033SO 2 NR\u2033R\u2033, C(O)C(O)R\u2033, and C(O)CH 2 C(O)R\u2033, a substituted or unsubstituted C1 to C6 alkyl, a substituted or unsubstituted C1 to C6 alkenyl, a substituted or unsubstituted C1 to C6 alkynyl, and a substituted or unsubstituted aryl; \n R\u2033 is independently selected from the group consisting of hydrogen, substituted C1-C4 aliphatic moiety, aliphatic moiety containing nitrogen, oxygen, or sulfur, or alternately, two R\u2033 moieties bound to the same nitrogen atom are optionally taken together with the nitrogen atom to form a 3-7 membered saturated or unsaturated ring having 1-2 additional heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur; \n Optionally, R 11  and R 12 , R 12  and R 13 , R 13  and R 14 , and R 14  and R 15  are taken together to form a 4-8 membered saturated or unsaturated ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur; \n m is an integer from 0-6; and \n or B is one or more monocyclic aryl, a 3-7 membered saturated or partially unsaturated carbocyclic ring, an 8-10 membered bicyclic saturated, partially unsaturated or aryl ring, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 7-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from the group consisting of nitrogen, oxygen or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur; \n wherein any and all of the substituted described are substituted with one or more groups that are independently a methyl group or methoxy group.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 96.0
- Lexical Diversity: 1.14706
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15328368', '13391148', '13129854', '14078792', '11004657']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6871472656142182
- 35 USC 102 Novelty (BERT): 0.5662606522704036
- Combined Prediction Score: 0.6750586042798368
- Mean Citation Score: 296.917648
- Max Citation Score: 552.2632
- Similarity Product: 310.3964948328972

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test