PATENT CLAIM ANALYSIS

Application Number: 16007464
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "646000"]

Abstract:
A method of treating pain, e.g., acute post-operative pain, by administering to a human patient(s) a therapeutically effective dose of tramadol intravenously in a dosing regimen which includes one or more loading doses administered at shortened intervals as compared to dosing at steady-state is disclosed. In certain embodiments, the dose of tramadol about 25 mg and the second (and optionally) third doses are intravenously administered at intervals of about 2 hours, and thereafter the tramadol is intravenously administered at a dosing interval of about 4 hours, until the patient no longer requires treatment with tramadol.

Claim (Index 1):
A method of administering tramadol for treating acute pain in human patients via an intravenous dosing regimen comprising\n intravenously administering a first dose of tramadol to a human patients in an amount of about 25 mg; intravenously administering a second dose of tramadol to the human patients in an amount of about 25 mg at about 2 hours after the first dose; intravenously administering a third dose of tramadol to the human patients in an amount of about 25 mg at about 2 hours after the second dose, wherein the dosing regimen provides a Cmax after the third intravenous dose of tramadol 25 mg and the Cmax of the intravenous dosing regimen after the third intravenous dose of tramadol 25 mg is similar to the Cmax achieved with an oral tramadol dose of 50 mg administered every 6 hours at about 44 hours after the first dose; and thereafter intravenously administering additional doses of tramadol to the human patients in an amount of about 25 mg tramadol at dosage intervals of about 4 hours, until the patient no longer requires treatment with intravenous tramadol, wherein the tramadol is tramadol base or a pharmaceutically acceptable salt of tramadol.

Metadata:
- Claim Count in Document: 43.0
- Percentile: 94.0
- Lexical Diversity: 1.63636
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15612665', '15622910', '15163111', '14713775', '13445526']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7777603444774832
- 35 USC 102 Novelty (BERT): 0.616474326496896
- Combined Prediction Score: 0.7616317426794246
- Mean Citation Score: 536.4159480000002
- Max Citation Score: 613.0105599999998
- Similarity Product: 476.24333274559007

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test