PATENT CLAIM ANALYSIS

Application Number: 16399571
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["424", "452000"]

Abstract:
There is described, inter alia, a coated bead comprising: (a) a granule; (b) a first layer coated over the granule, the first layer comprising a first amount of an active pharmaceutical ingredient comprising a central nervous system stimulant; and (c) a second layer coated over the first layer, the second layer being present in an amount sufficient to substantially delay release of the active pharmaceutical ingredient in the first layer until after the coated bead reaches a distal intestine portion of a subject to whom the coated bead is administered; and (d) the third layer coated over the second layer, the third layer comprising a second amount of the active pharmaceutical ingredient, the third layer being configured to permit substantially immediate release of the active pharmaceutical ingredient comprised therein. Embodiments related to a solid oral pharmaceutical composition are also described.

Claim (Index 1):
A dosage form comprising an immediate release methylphenidate hydrochloride component and a controlled/delayed release methylphenidate hydrochloride component, wherein the immediate release methylphenidate component and the controlled/delayed release methylphenidate component, together, provide 25, 35, 45, 55, 70, 85, or 100 mg of methylphenidate hydrochloride;\n wherein upon oral administration, the dosage form provides efficacious treatment of attention deficit hyperactivity disorder (\u201cADHD\u201d) for 16 hours after a single oral administration; and wherein the dosage form has an in vitro methylphenidate hydrochloride dissolution rate, and wherein the in vitro methylphenidate hydrochloride dissolution rate does not increase in the presence of 5% or 20% ethanol when measured under in vitro conditions with stirring at 100 rpm at pH 1.2 for 2 hours in 900 mL of a medium comprising up to about either 5% or 20% v/v ethanol.

Metadata:
- Claim Count in Document: 33.0
- Percentile: 100.0
- Lexical Diversity: 2.46154
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16185730', '16399580', '16399574', '16120900', '16282876']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8177416448324291
- 35 USC 102 Novelty (BERT): 0.5438288331482412
- Combined Prediction Score: 0.7903503636640102
- Mean Citation Score: 524.565014
- Max Citation Score: 531.5322
- Similarity Product: 430.227877111423

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test