PATENT CLAIM ANALYSIS

Application Number: 15937725
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["552", "615000"]

Abstract:
The invention relates to a 17α-alkynyl-androst-5-ene-3β,7β,17β-triol compound essentially free of steroid side-product lacking an oxygen substituent at position 7 and processes for preparing the same.

Claim (Index 1):
A 17\u03b1-alkynyl-androst-5-ene-3\u03b2,7\u03b2,17\u03b2-triol compound essentially free of steroid side-product lacking an oxygen substituent at position 7, made by a process comprising the steps of,\n (a) contacting a compound having the structure with a reducing agent to convert the \u2550O functional group at position 7 to hydroxy predominantly in the \u03b2-configuration, wherein R 1  is \u2014H, C 1-6  alkyl, C 3-6  cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl and R 2  is \u2014H, C 1-6  alkyl or aryl; (b) converting the \u2550NOR 2  group at position 17 in the reaction product from step (a) to a \u2550O group to obtain a 7\u03b2-hydroxy-17-one compound; (c) converting the \u2014OC(O)R 1  group at position 3 of the 7\u03b2-hydroxy-17-one compound to a 3\u03b2-hydroxy derivative of the 7\u03b2-hydroxy-17-one; (d) converting the hydroxy groups at positions 3 and 7 in the 3\u03b2-hydroxy derivative of the 7\u03b2-hydroxy-17-one compound from step (c) to (R 3 ) 3 SiO\u2014 groups, wherein each R 3  independently is C 1-6  alkyl or aryl; and (e) contacting the reaction product of step (d) with an compound having the structure of M-C\u2550C\u2014Si(R 5 ) 3 , wherein R 5  independently are C 1-6  alkyl or aryl and M is a Group I, Group II or transition metal, wherein 17\u03b1-alkynyl-androst-5-ene-3\u03b2,7\u03b2,17\u03b2-triol essentially free of 17\u03b1-alkynyl-androst-5-ene-3\u03b2,17\u03b2-diol is obtained.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 90.0
- Lexical Diversity: 1.0
- Patent Class: 552.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12479626', '14886738', '13664304', '15348107', '14459528']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7430588781599183
- 35 USC 102 Novelty (BERT): 0.7222991270479845
- Combined Prediction Score: 0.7409829030487249
- Mean Citation Score: 540.2077939999998
- Max Citation Score: 642.5684
- Similarity Product: 630.7280126721382

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test