PATENT CLAIM ANALYSIS

Application Number: 16195227
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["435", "252300"]

Abstract:
The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Claim (Index 4):
The recombinant transaminase polypeptide of  claim 1 , wherein said recombinant transaminase polypeptide is capable of converting 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one (\u201cketoamide substrate\u201d) to (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine (\u201cproduct\u201d) under a defined reaction condition in the presence of an amino group donor isopropylamine to levels of the product detectable by HPLC-UV at 210 nm, where the reaction condition comprises about 2 g/L ketoamide substrate, about 0.5 M isopropylamine, about 22\u00b0 C., about pH 7.5, about 5% DMSO, about 100 \u03bcM pyridoxal phosphate, and about 20 mg/mL of transaminase polypeptide.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 98.0
- Lexical Diversity: 1.22222
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15915437', '14518143', '15140809', '15376837', '14818885']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7739065994225092
- 35 USC 102 Novelty (BERT): 0.6708176363002085
- Combined Prediction Score: 0.7635977031102791
- Mean Citation Score: 667.80694
- Max Citation Score: 683.7034
- Similarity Product: 665.4689223588109

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test