PATENT CLAIM ANALYSIS

Application Number: 15956311
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["544", "350000"]

Abstract:
Novel compounds of Formula I and their use in therapeutic treatments.

Claim (Index 1):
A process of manufacturing a compound of Formula I: or a pharmaceutically acceptable solvate thereof, wherein: R 1  is H or F; R 1\u2032  is H; R 2  is H, F or Cl; R 2\u2032  is H or F; R 3  is F or Cl; R 4  is methyl, trifluoromethyl, difluoromethyl or fluoromethyl; X 1  is N and X 2  is S; or X 1  is S and X 2  is N; and  represents a single or a double bond depending on X 1  and X 2 ; comprising the following steps: a) reacting a compound of Formula (i) wherein: PG represents a suitable protecting group; with a compound of Formula (ii) wherein: R 4\u2032  is R 4  as defined above or H; X 1  and X 2  are as defined above;  represents a single or a double bound depending on X 1  and X 2 ; so as to obtain a compound of Formula (iii) wherein PG, R 4\u2032 , X 1  and X 2  are as defined above and   represents a single or a double bound depending on X 1  and X 2 ; b) deprotecting compound of Formula (iii) with a suitable deprotection agent to afford compound of Formula (iv) wherein R 4\u2032 , X 1  and X 2  are as defined above and   represents a single or a double bound depending on X 1  and X 2 ; c) when R 4\u2032  is H, a trifluoromethyl or difluoromethyl group is introduced by direct C\u2014H trifluoro- or difluoromethylation, leading to compound of Formula (v) wherein X 1  and X 2  are as defined above and R 4  is trifluoromethyl, or difluoromethyl and   represents a single or a double bound depending on X 1  and X 2 ; d) N-acylating compound of Formula (iv) wherein R 4\u2032  is not H or compound of Formula (v) with a compound of Formula (vi) wherein R 1 , R 1\u2032 , R 2 , R 2\u2032  and R 3  are as defined above; to afford compound of Formula I as defined above.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 91.0
- Lexical Diversity: 1.0
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14781180', '15796028', '15807733', '14777543', '14799208']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8653833261358734
- 35 USC 102 Novelty (BERT): 0.6645281989390452
- Combined Prediction Score: 0.8452978134161906
- Mean Citation Score: 626.536514
- Max Citation Score: 671.0949
- Similarity Product: 648.7810918559073

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test