PATENT CLAIM ANALYSIS

Application Number: 16028532
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["435", "370000"]

Abstract:
The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In particular, the invention relates to an ex vivo method for preparing induced pluripotent stein cells (iPSCs) from a target cell population comprising cells from aged donors or senescent cells, said method comprising the steps of culturing said target cell population tinder appropriate conditions for reprogramming said cells into iPSCs, wherein said appropriate conditions comprises increasing expression in said target cells, of at least the following reprogramming factors: Oct4, Klf4, Sox2, Myc, Lin28 and, optionally Nanog.

Claim (Index 18):
A method of performing an autologous graft in an aged patient in need thereof comprising the steps of\n a) providing a target cell population comprising cells from aged donors or senescent cells; b) culturing said target cell population under appropriate conditions for reprogramming said target cell population into induced pluripotent stem cells (iPSCs), wherein said appropriate conditions comprise increasing expression in said target cell population of at least the following combination of reprogramming factors: i. a reprogramming factor encoded by one gene of the Oct gene family, ii. a reprogramming factor encoded by one gene of the Klf gene family, iii. a reprogramming factor encoded by one gene of the Sox gene family, iv. a reprogramming factor encoded by one gene of the Myc gene family, v. Lin28, and, optionally, vi. Nanog; and c) performing an autologous graft in an aged patient using said iPSCs.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 95.0
- Lexical Diversity: 1.78125
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14009662', '13893166', '15261803', '14117589', '14258971']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.602948417635452
- 35 USC 102 Novelty (BERT): 0.6551794127362566
- Combined Prediction Score: 0.6081715171455325
- Mean Citation Score: 448.742578
- Max Citation Score: 639.40155
- Similarity Product: 607.1011542210819

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test