PATENT CLAIM ANALYSIS

Application Number: 15892331
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "093710"]

Abstract:
The present disclosure provides methods for re-stimulating TIL populations that lead to improved phenotype and increased metabolic health of the TILs and provides methods of assaying for TIL populations to determine suitability for more efficacious infusion after re-stimulation.

Claim (Index 24):
The method of  claim 23 , wherein the method further comprises prior to step (iv) a step of performing an additional second expansion by supplementing the cell culture medium of the third population of TILs with additional IL-2, additional OKT-3, and additional APCs, wherein the additional second expansion is performed for at least 14 days to obtain a larger therapeutic population of TILs than obtained in step (iii), wherein the larger therapeutic population of TILs comprises an increased subpopulation of effector T cells and/or central memory T cells relative to the third population of TILs.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 88.0
- Lexical Diversity: 1.3
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15892311', '15874718', '15800967', '14917214', '15110111']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.778537393303202
- 35 USC 102 Novelty (BERT): 0.5742297812662753
- Combined Prediction Score: 0.7581066320995095
- Mean Citation Score: 395.835198
- Max Citation Score: 565.9608
- Similarity Product: 349.2561303244113

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test