PATENT CLAIM ANALYSIS

Application Number: 15981854
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["435", "006100"]

Abstract:
The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c).

Claim (Index 2):
A method for obtaining a bifunctional molecule comprising an encoded molecule part and a coding part, said method comprising:\n adding one or more molecule fragments to a nascent bifunctional molecule, wherein said nascent bifunctional molecule comprises a first reactive group suitable for coupling of said one or more molecule fragments and a second reactive group suitable for enzymatic coupling of one or more oligonucleotide identifiers; and adding one or more oligonucleotide identifiers; under conditions where said one or more molecule fragments become covalently attached to said first reactive group, and said one or more oligonucleotide identifiers become covalently attached to said second reactive group using one or more enzymes, to produce said bifunctional molecule; wherein the reactions involving said first and said second reactive groups may be performed in any order; wherein the oligonucleotide identifiers comprise natural oligonucleotides; wherein said first reactive group is chosen from the following list of reactive groups: \u2014NH 2 , \u2014COOH, \u2014CHO, \u2014OH, \u2014NHR, \u2014CSO 2 OH, phenylchloride, \u2014SH, and \u2014SS; and wherein the encoded molecule part of the bifunctional molecule comprises one or more molecule fragments; wherein the coding part of the bifunctional molecule comprises one or more oligonucleotide identifier(s); and wherein the encoded molecule part comprises a polycyclic heterocycle.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 93.0
- Lexical Diversity: 2.46377
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14067789', '11719846', '14571941', '10175539', '12834072']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6306562700937661
- 35 USC 102 Novelty (BERT): 0.636587921279395
- Combined Prediction Score: 0.631249435212329
- Mean Citation Score: 422.12705000000005
- Max Citation Score: 652.50995
- Similarity Product: 563.1226049426049

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test