PATENT CLAIM ANALYSIS

Application Number: 16021551
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "210210"]

Abstract:
A compound of formula (I): wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR 1  or NR 2 R 3 , and R 1  ,R 2 , R 3  and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.

Claim (Index 11):
The process as defined in  claim 1 , wherein the compound of formula (Ia) is selected from the following group of compounds: # Structure Name 156 (2S,5R)-2-((2-(methylamino)ethoxy)carbamoyl)- 7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   157 (2S,5R)-2-((2- (methylamino)propoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   158 (2S,5R)-2-((2-amino-2- methylpropoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   159 (2S,5R)-2-((2-methyl-2-(methylamino)propoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   160 (2S,5R)-2-(((1-aminocyclopropyl)methoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   161 (2S,5R)-2-(((1- (methylamino)cyclopropyl)methoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   162 (2S,5R)-2-((2-aminobutoxy)carbamoyl)-7-oxo- 1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   163 (2S,5R)-2-((2-aminobutoxy)carbamoyl)-7-oxo- 1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   164 (2S,5R)-2-((2-amino-3- methylbutoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   165 (2S,5R)-2-((3-methyl-2-(metthylamino)butoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   166 (2S,5R)-2-((2-amino-3,3-dimethylbutoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   167 (2S,5R)-2-((3-methyl-2-(methylamino)butoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   168 (2S,5R)-2-(((1- (aminomethyl)cyclopropyl)methoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   169 (2S,5R)-2-(((1- ((methylamino)methyl)cyclopropyl) methoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   170 (2S,5R)-2-((2- (isopropylamino)propoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   171 (2S,5R)-2-((2-(methylamino)cyclopropoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   172 (2S,5R)-2-(((2-(methylamino)cyclopentyl)oxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   173 (2S,5R)-2-((2-amino-2- phenylethoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   174 (2S,5R)-2-((2-amino-2-cyclohexylethoxy) carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   175 (2S,5R)-2-((2-amino-2-cyclopentylethoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   176 (2S,5R)-2-((2-amino-2-cyclopropylethoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   177 (2S,5R)-2-((2-amino-2- cyclobutylethoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   178 (2S,5R)-2-((2-amino-2-(tetrahydro-2H-pyran-4- yl)ethoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   179 (2S,5R)-2-((2-aminocyclobutoxy)carbamoyl)-7- oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   180 (2S,5R)-2-((2-(methylamino)cyclobutoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   181 (2S,5R)-2-((2-amino-2-(piperidin-4-yl)ethoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   182 (2S,5R)-2-((2-amino-2-(1,1-dioxidotetrahydro- 2H-thiopyran-4-yl)ethoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   183 (2S,5R)-2-((2-amino-2-(pyridin-3-yl)ethoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   184 (2S,5R)-2-((2-amino-2-(pyridin-2-yl)ethoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   185 (2S,5R)-2-((2-amino-2-(thiophen-2-yl)ethoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   186 (2S,5R)-2-((2-amino-2-(furan-2-yl)ethoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   187 (2S,5R)-2-(((2-azabicyclo[3.1.0]hexan-3- yl)methoxy) carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   188 (2S,5R)-2-(((6-methyl-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazin-1- yl)methoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   189 (2S,5R)-2-((((5R)-5-(hydroxymethyl)pyrrolidin- 3-yl)oxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   190 (2S,5R)-2-((((5S)-5-methylpyrrolidin-3-yl)oxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   191 (2S,5R)-2-((2-amino-2-(thiazol-2-yl)ethoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   192 (2S,5R)-2-((2-amino-2-(2-aminothiazol-4- yl)ethoxy) carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   193 (2S,5R)-2-((2-amino-2-(1-methyl-1H-imidazol- 2-yl)ethoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   194 (2S,5R)-2-((2-amino-2-(1-methyl-1H-imidazol- 5-yl)ethoxy)carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   195 (2S,5R)-2-((2-amino-2-(thiazol-5-yl)ethoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   196 (2S,5R)-2-(((3-aminooxetan-3-yl)methoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate   197 (2S,5R)-2-(((3-aminotetrahydrofuran-3- yl)methoxy) carbamoyl)-7-oxo-1,6- diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate   198 (2S,5R)-2-(((3-aminopyrrolidin-3-yl)methoxy) carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan- 6-yl hydrogen sulfate.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 94.0
- Lexical Diversity: 1.41304
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15171237', '13690398', '13917932', '14300493', '12812763']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8416691143196308
- 35 USC 102 Novelty (BERT): 0.6147838920418407
- Combined Prediction Score: 0.8189805920918517
- Mean Citation Score: 499.65012800000005
- Max Citation Score: 568.8289
- Similarity Product: 504.6862233192205

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test