PATENT CLAIM ANALYSIS

Application Number: 15981574
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-07
Patent Classification: ["514", "299000"]

Abstract:
Efficient methods are provided for large scale production of ethyl cocaine-free cocaine hydrochloride. Compositions and methods comprising administration of cocaine hydrochloride are provided.

Claim (Index 1):
The composition of  claim 18 , wherein the (\u2212)-cocaine hydrochloride is prepared by a method comprising:\n exposing (+)-2-carbomethoxy-3-tropinone (2-CMT) or a salt thereof to sodium mercury amalgam (Na\u2014Hg) and sulfuric acid in an aqueous solution whereby the 2-CMT or salt thereof is converted to a mixture of compounds comprising (\u2212)-ecognine methyl ester ((\u2212)-EME) or a pharmaceutically acceptable salt thereof and pseudoecgonine methyl ester (PEM) or a pharmaceutically acceptable salt thereof, wherein a sodium salt of the sulfuric acid formed as a by-product during the reaction is allowed to precipitate during the exposing step; benzoylating the (\u2212)-EME or a pharmaceutically acceptable salt thereof to form (\u2212)-cocaine base; and adding hydrochloric acid to the (\u2212)-cocaine base to form the (\u2212)-cocaine hydrochloride.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 93.0
- Lexical Diversity: 1.38889
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11303309', '15470133', '15245935', '15849575', '15935776']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6932705754974692
- 35 USC 102 Novelty (BERT): 0.5150011835970668
- Combined Prediction Score: 0.675443636307429
- Mean Citation Score: 250.173112
- Max Citation Score: 308.0337
- Similarity Product: 241.33041829478145

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test