PATENT CLAIM ANALYSIS

Application Number: 15954291
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-10
Patent Classification: ["435", "377000"]

Abstract:
Methods are disclosed for reprogramming a somatic cell, including an adherent cell and a cell in suspension, into an induced pluripotent stem comprising expressing exogenous Sox-2, exogenous Klf-4, exogenous Oct3/4 from DNA that has not integrated into the genome of the somatic cell, suppressing p53 activity within the somatic cell, and exposing the somatic cell to reprogramming-assistance factors comprising an exogenous Alk-5 inhibitor, an exogenous histone deacetylase inhibitor, and an exogenous activator of glycolysis. Compositions and kits for use in such methods are also disclosed as are cells made by such a method.

Claim (Index 2):
The method according to  claim 1 , wherein the method further comprises expressing exogenous Epstein-Bar nuclear antigen-1 (EBNA-1) in the somatic cell from DNA that has not integrated into the genomic DNA of the somatic cell, and wherein the DNA that has not integrated into the genomic DNA of the somatic cell comprises at least one plasmid with an Epstein-Barr virus origin of replication (oriP).

Metadata:
- Claim Count in Document: 47.0
- Percentile: 91.0
- Lexical Diversity: 1.71667
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12939454', '13197529', '14438106', '13997014', '13389359']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6796980792613967
- 35 USC 102 Novelty (BERT): 0.5731400780734551
- Combined Prediction Score: 0.6690422791426026
- Mean Citation Score: 477.53489
- Max Citation Score: 523.6735
- Similarity Product: 374.05481870770456

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test