PATENT CLAIM ANALYSIS

Application Number: 15969256
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-03
Patent Classification: ["530", "300000"]

Abstract:
The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids comprising the peptoid polymers provided herein. The peptoid polymers and peptoid-peptide hybrids provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.

Claim (Index 51):
A cryoprotectant solution comprising a peptoid polymer according to formula (I): a tautomer thereof or stereoisomer thereof, wherein: each R 1  is independently selected from the group consisting of H, optionally substituted C 1-18  alkyl, optionally substituted C 2-18  alkenyl, optionally substituted C 2-18  alkynyl, optionally substituted C 1-18  hydroxyalkyl, optionally substituted alkoxy, optionally substituted C 1-18  alkylamino, optionally substituted C 1-18  alkylthio, optionally substituted carboxyalkyl, C 3-10  cycloalkyl, heterocycloalkyl, aryl, heteroaryl, (C 3-10  cycloalkyl)alkyl, (heterocycloalkyl)alkyl, arylalkyl, and heteroarylalkyl, wherein at least 4 instances of R 1  are independently selected optionally substituted C 1-18  hydroxyalkyl groups, and wherein any of the cycloalkyl, heterocycloalkyl, aryl, and heteroaryl groups is optionally and independently substituted with one or more R 3  groups; each R 2  is independently selected from the group consisting of H, optionally substituted C 1-18  alkyl, optionally substituted C 2-18  alkenyl, optionally substituted C 2-18  alkynyl, optionally substituted C 1-18  hydroxyalkyl, optionally substituted C 1-18  alkylamino, optionally substituted C 1-18  alkylthio, and optionally substituted carboxyalkyl; each R 3  is independently selected from the group consisting of halogen, oxo, thioxo, \u2014OH, \u2014SH, amino, C 1-8  alkyl, C 1-8  hydroxyalkyl, C 1-8  alkylamino, and C 1-8  alkylthio; X and Y are independently selected from the group consisting of H, optionally substituted C 1-8  alkyl, optionally substituted C 1-8  acyl, optionally substituted C 1-8  alkylamino, \u2014OH, \u2014SH, \u2014NH 2 , carboxy, optionally substituted C 1-8  hydroxyalkyl, optionally substituted C 1-8  alkylamino, optionally substituted C 2-8  alkylthio, optionally substituted C 1-8  carboxyalkyl, and halogen, or alternatively X and Y are taken together to form a covalent bond; and the subscript n, representing the number of monomers in the polymer, is between 8 and 50.

Metadata:
- Claim Count in Document: 140.0
- Percentile: 93.0
- Lexical Diversity: 1.9434
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15486522', '13731525', '14282228', '15159184', '15281202']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6504495175258436
- 35 USC 102 Novelty (BERT): 0.6394053407832875
- Combined Prediction Score: 0.6493450998515881
- Mean Citation Score: 281.115264
- Max Citation Score: 632.25684
- Similarity Product: 568.2381261202598

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test