PATENT CLAIM ANALYSIS

Application Number: 16087308
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["548", "430000"]

Abstract:
Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.

Claim (Index 16):
A method for preparing a compound represented by Formula (I), comprising the following steps: (a) coupling a spirocyclopropane lactam shown by Formula V with a compound shown by Formula VI under the action of a base to obtain a compound shown by the Formula VII: wherein R 1  is a protecting group of amino, preferably tert-butoxycarbonyl (Boc); R 2  is halogen or p-toluenesulfonyloxy; (b) removing a protecting group of amino of the compound shown by Formula VII to obtain a compound shown by Formula VIII or a salt thereof: wherein R 1  is an protecting group of amino, preferably tert-butyloxycarbonyl (Boc); (c) reacting the compound shown by Formula VIII or a salt thereof with a compound shown by Formula IX or a salt thereof under the action of a base to obtain a compound shown by Formula XI: wherein Y is halogen or sulfonyloxy; (d) reacting the compound shown by Formula XI with phosphoric acid to obtain the compound of Formula I:

Metadata:
- Claim Count in Document: 7.0
- Percentile: 97.0
- Lexical Diversity: 1.47692
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15514326', '15763676', '16083485', '13994085', '16345744']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7004008071291986
- 35 USC 102 Novelty (BERT): 0.5136686580360024
- Combined Prediction Score: 0.681727592219879
- Mean Citation Score: 262.935172
- Max Citation Score: 271.25452
- Similarity Product: 184.78476266142368

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test