PATENT CLAIM ANALYSIS

Application Number: 15753788
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["435", "325000"]

Abstract:
The present invention relates to an in vitro tumor relapse assay method, which method comprises providing a 3-dimensional cell culture or tissue comprising immortalized, malignant, cancerous and/or neoplastic cells, exposing the 3-dimensional cell culture or tissue to at least one anti-cancer agent, interrupting the exposure and determining the effect of said exposure and interruption on the 3-dimensional cell culture or tissue.

Claim (Index 13):
The tumor relapse assay method according to  claim 12 , wherein the determination of a tumor relapse index comprises the following steps:\n a) determine the cell proliferation and/or viability of at least\n (i) one 3-dimensional cell culture or tissue which has been exposed to the at least one anti-cancer agent in an interrupted fashion (\u201cpulsed treatment group\u201d), \n (ii) one 3-dimensional cell culture or tissue which has been exposed to the at least one anti-cancer agent without any interruption (\u201ccontinuous treatment group\u201d), and \n (iii) one 3-dimensional cell culture or tissue which has not been exposed to the at least one anti-cancer agent (\u201cuntreated control group\u201d) \n at a given point of time,\n b) determine\n (i) the difference (e.g., d2) between the cell proliferation and/or viability of at least one 3-dimensional cell culture or tissue in the continuous treatment group and at least one 3-dimensional cell culture or tissue in the pulsed treatment group, and \n (ii) the difference (e.g., d 2 ) between the cell proliferation and/or viability of at least one 3-dimensional cell culture or tissue in the pulsed treatment group and at least one 3-dimensional cell culture or tissue in the untreated control group, and \n \n c) form a quotient out of the two differences (e.g., d 1 /d 2 ) to deliver a tumor relapse index.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 88.0
- Lexical Diversity: 1.45652
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12802666', '14424948', '15314245', '12495417', '12773540']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6055669618757831
- 35 USC 102 Novelty (BERT): 0.4987572097727141
- Combined Prediction Score: 0.5948859866654762
- Mean Citation Score: 206.602884
- Max Citation Score: 222.47926
- Similarity Product: 146.00291610921386

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test