PATENT CLAIM ANALYSIS

Application Number: 15764193
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "193000"]

Abstract:
Thalidomide analogs and methods of using the thalidomide analogs are disclosed. Some embodiments of the disclosed compounds exhibit anti-angiogenic and/or anti-inflammatory activity. Certain embodiments of the disclosed compounds are non-teratogenic.

Claim (Index 1):
A thalidomide analog or pharmaceutically acceptable salt thereof, wherein the thalidomide analog is a compound according to general formula I or wherein general formula I is where Y 1  is a bond, \u2014CH 2 \u2014, or \u2014CH(CH 3 )\u2014;\n A is general formula II or A is \u2014NH 3 X where X is an anion with a \u22121 charge, wherein general formula II is \n where bonds represented by \u201c-----\u201d are optional bonds, and each bond represented by \u201c \u201d is a single or double bond as needed to satisfy valence requirements, R 1  is \u2014H, \u2014NO 2 , \u2014NH 2 , \u2014OC(O)CH 3 , or \u2014NO 2 H, R 2  is \u2014H, \u2014NH 2 , or \u2014N(H)CH(CH 3 ) 2 , Z 1  is CH 2 , C\u2550O, or CH, and Z 2  is C\u2550O, CH 2 , C\u2550S, Ring B is: where each bond represented by \u201c \u201d is a single or double bond as needed to satisfy valence requirements, Z 3  is C\u2550O, C\u2550S, or CH; Z 4  is C\u2550O, C\u2550S, or CH, and at least one of Z 3  and Z 4  is C\u2550O or C\u2550S, R 3  is \u2014H or \u2014OH, R 4  is \u2014H or \u2014CH 3  and R 5  and R 6  are both \u2014H or both \u2014CH 3 ; wherein:\n if ring B is \n R 1  is \u2014H, \u2014NH 2  or \u2014NO 2 , R 2  and R 3  are \u2014H, Z 1  is CH 2 , and Z 2  is C\u2550O, then Y 1  is not a bond;\n if ring B is \n R 1  and R 2  are H, Z 1  is CH 2  and Z 2  is C\u2550O, then Y 1  is not a bond;\n if ring B is \n and R 1  and R 2  are H, then one of Z 1  and Z 2  is other than C\u2550O; and\n if ring B is \n then\n (i) R 1  is not \u2014NH 2 , (ii) if R 1  is \u2014NO 2  and Y 1  is a bond, then at least one of Z 1  and Z 2  is C\u2550O and one of Z 3  and Z 4  is other than C\u2550O or C\u2550S, or if both Z 1  and Z 2  are C\u2550O, then Z 3  is C\u2550O or C\u2550S and Z 4  is C\u2550S, (iii) if R 2  is \u2014NH 2  and Y 1  is a bond, then one of Z 1  and Z 2  is other than C\u2550O, and one of Z 3  and Z 4  is other than C\u2550O or C\u2550S, (iv) if R 2  is \u2014NO 2  and Y 1  is a bond, then one of Z 3  and Z 4  is other than C\u2550O or C\u2550S, (v) if R 2  is N(H)CH(CH 3 ) 2 , Y 1  is a bond, Z 1  is CH 2  and Z 2  is C\u2550O, then one of Z 3  and Z 4  is other than C\u2550O, and (vi) if A is \u2014NH 3 X, X is CF 3 CO 2 \u2014, and Y 1  is a bond, then at least one of Z 3  and Z 4  is other than C\u2550O.

Metadata:
- Claim Count in Document: 36.0
- Percentile: 90.0
- Lexical Diversity: 1.57143
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13153355', '12767647', '10572485', '13498067', '13648625']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7829257584772307
- 35 USC 102 Novelty (BERT): 0.5125219540481328
- Combined Prediction Score: 0.7558853780343209
- Mean Citation Score: 257.70049
- Max Citation Score: 277.90332
- Similarity Product: 189.3918794421601

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test