PATENT CLAIM ANALYSIS

Application Number: 16107385
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["544", "235000"]

Abstract:
Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

Claim (Index 1):
A compound of formula I: wherein,\n R 1  is hydrogen, lower alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, alkylheterocycloalkyl, alkylaryl, alkylheteroaryl, aryl or heteroaryl, each of which is optionally substituted; \n R 2  is hydrogen, lower alkyl, lower alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, alkylheterocycloalkyl, alkylaryl, alkylheteroaryl, aryl, heteroaryl, \u2014C(O)OR 12 , or \u2014CO\u2014NR 12 , each of which is optionally substituted; \n R 3  is hydrogen, lower alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, alkylheterocycloalkyl, alkylaryl, alkylheteroaryl, aryl or heteroaryl, each of which is optionally substituted; or \n R 2  and R 3  are optionally joined, together with the atoms to which they are attached, to form a mono or bicyclic ring that is carbocyclic or heterocyclic, each of which is optionally substituted; \n G is CHR 2  or NR 2  when b and c are both single bonds, or G is CR 2  or N when one of b and c is a double bond; \n Q is NH or CH 2  when d and e are single bonds, or N or CH when one of d or e is a double bond, or; \n X is N; \n Z is CH 2 , C\u2550O, C\u2550S or a bond when b is a single bond, or CH or N when b is a double bond; \n b, c, d, e, and f are each independently a single bond or a double bond, provided that when b is a double bond, c is a single bond; when c is a double bond, b and d are single bonds; \n when d is a double bond, c and e are single bonds; when e is a double bond, d and f are single bonds; and when f is a double bond, e is a single bond; \n Y 1 , Y 2  and Y 3  are each CH; \n L 1  is \u2014C\u2261C\u2014, \u2014HC\u2550CH\u2014, -(lower alkyl)C\u2550C(lower alkyl)-, \u2014CH 2 \u2014CH 2 \u2014, \u2014CO\u2014CH 2 \u2014, \u2014CH(OH)\u2014CH 2 , \u2014CH 2 \u2014CO\u2014, \u2014C O-6 alkyl-O\u2014C O-6 alkyl-, \u2014NR 12 SO\u2014, \u2014SONR 12 \u2014, \u2014NR 12 SO 2 \u2014, \u2014SO 2 NR 12 \u2014, \u2014NR 12 \u2014CO\u2014, \u2014CO\u2014NR 12 \u2014, \n R 12  is hydrogen or lower alkyl; W 1  and W 2  are each independently N or CH; W 3  is O, S or NR 4 ; and R 4  is hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof; provided that at least one of c and d is a double bond.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.63333
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12972293', '14299364', '14122519', '14124455', '15013741']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7931808727505465
- 35 USC 102 Novelty (BERT): 0.5642174378419788
- Combined Prediction Score: 0.7702845292596897
- Mean Citation Score: 391.818932
- Max Citation Score: 464.89075
- Similarity Product: 332.4931373749524

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test