PATENT CLAIM ANALYSIS

Application Number: 16319951
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-07
Patent Classification: ["544", "277000"]

Abstract:
There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

Claim (Index 5):
A compound (cpd), or pharmaceutically acceptable salt according to  claim 1 , selected from the group consisting of:\n cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 3), cis-4-[6-amino-2-(pyridin-3-yl)-9H-purin-9-yl]-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 4), cis-4-[6-amino-2-(pyridin-4-yl)-9H-purin-9-yl]-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 9), cis-4-[6-amino-2-(2-fluoropyridin-4-yl)-9H-purin-9-yl]-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 15), cis-4-[6-amino-2-(4-hydroxyphenyl)-9H-purin-9-yl]-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 17), cis-4-[6-amino-2-(3-hydroxyphenyl)-9H-purin-9-yl]-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 18), cis-4-[6-amino-2-(6-fluoropyridin-3-yl)-9H-purin-9-yl]-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 19), cis-4-[6-amino-2-(2-methoxypyridin-4-yl)-9H-purin-9-yl]-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 21), 3-(6-amino-9-{cis-4-[(3-methoxyphenyl)carbamoyl]cyclohexyl}-9H-purin-2-yl)benzamide (cpd 26), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-{4-[(trifluoromethyl) sulfonyl]phenyl}cyclohexanecarboxamide (cpd 27), 4-(6-amino-9-{cis-4-[(3-methoxyphenyl)carbamoyl]cyclohexyl}-9H-purin-2-yl)-N-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}benzamide (cpd 29), 3-(6-amino-9-{cis-4-[(3-methoxyphenyl)carbamoyl]cyclohexyl}-9H-purin-2-yl)-N-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}benzamide (cpd 30), 3-(6-amino-9-{cis-4-[(3-methoxyphenyl)carbamoyl]cyclohexyl}-9H-purin-2-yl)-N-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)benzamide (cpd 31), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(3,4-dimethoxyphenyl)cyclohexanecarboxamide (cpd 32), 4-(6-amino-9-{cis-4-[(3-methoxyphenyl)carbamoyl]cyclohexyl}-9H-purin-2-yl)-N-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)benzamide (cpd 33), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-{4-[2-({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}amino)-2-oxoethyl]phenyl}cyclohexanecarboxamide (cpd 35), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-{4-[2-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}amino)-2-oxoethyl]phenyl}cyclohexanecarboxamide (cpd 36), cis-4-[6-amino-2-(pyridin-4-yl)-9H-purin-9-yl]-N-(3,4-dimethoxyphenyl)cyclohexanecarboxamide (cpd 37), cis-4-(6-amino-2-iodo-9H-purin-9-yl)-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 41), cis-4-(6-amino-2-ethynyl-9H-purin-9-yl)-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 45), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(3-methylphenyl)cyclohexanecarboxamide (cpd 48), cis-4-[6-amino-2-(pyridin-4-yl)-9H-purin-9-yl]-N-(3-methylphenyl)cyclohexanecarboxamide (cpd 50), cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexanecarboxamide (cpd 53), cis-4-[6-amino-2-(3-hydroxyprop-1-yn-1-yl)-9H-purin-9-yl]-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 60), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]cyclohexanecarboxamide (cpd 64), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 65), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(1,3-benzothiazol-6-yl)cyclohexanecarboxamide (cpd 69), cis-4-(6-amino-2-iodo-9H-purin-9-yl)-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 70), 4-({[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]carbonyl}amino)-N-cyclohexylbenzamide (cpd 71), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 72), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 73), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(4-phenyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 74), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 75), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(pyridin-2-yl)cyclohexanecarboxamide (cpd 76), cis-4-(6-amino-2-ethynyl-9H-purin-9-yl)-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 77), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(1H-imidazol-2-yl)cyclohexanecarboxamide (cpd 79), cis-4-[6-amino-2-(pyridin-4-yl)-9H-purin-9-yl]-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 81), cis-4-(6-amino-2-methoxy-9H-purin-9-yl)-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 83), cis-4-(6-amino-2-methoxy-9H-purin-9-yl)-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 84), 3-(6-amino-9-{cis-4-[(4-methyl-1,3-thiazol-2-yl)carbamoyl]cyclohexyl}-9H-purin-2-yl)-N-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)benzamide bis-trifluoroacetate (cpd 85), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-{4-[2-(1,4\u2032-bipiperidin-1\u2032-yl)-2-oxoethyl]-1,3-thiazol-2-yl}cyclohexanecarboxamide (cpd 86), cis-4-(6-amino-2-cyclopropyl-9H-purin-9-yl)-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 87), methyl cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexanecarboxylate (cpd 88), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[6-(methylsulfony)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide (cpd 89), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(6-chloro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 90), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(4-methoxy-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 91), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(6-methoxy-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 92), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5,6-dimethyl-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 93), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5-chloro-1,3-benzoxazol-2-yl)cyclohexanecarboxamide (cpd 94), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(1-methyl-1H-benzimidazol-2-yl)cyclohexanecarboxamide (cpd 95), 3-(6-amino-9-{cis-4-[(4-methyl-1,3-thiazol-2-yl)carbamoyl]cyclohexyl}-9H-purin-2-yl)benzamide (cpd 96), 3-(6-amino-9-{trans-4-[(4-methyl-1,3-thiazol-2-yl)carbamoyl]cyclohexyl}-9H-purin-2-yl)benzamide (cpd 97), cis-4-{6-amino-2-[(trimethylsilyl)ethynyl]-9H-purin-9-yl}-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 98), cis-4-{6-amino-2-[3-(benzyloxy)phenyl]-9H-purin-9-yl}-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 100), cis-4-(6-amino-2-cyano-9H-purin-9-yl)-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 102), cis-4-[6-amino-2-(3-hydroxyphenyl)-9H-purin-9-yl]-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 103), cis-4-[6-amino-2-(1H-pyrazol-3-yl)-9H-purin-9-yl]-N-(3-methoxyphenyl)cyclohexanecarboxamide (cpd 107), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide (cpd 108), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(1,5-dimethyl-1H-pyrazol-3-yl)cyclohexanecarboxamide (cpd 109), cis-4-[6-amino-2-(1H-pyrazol-3-yl)-9H-purin-9-yl]-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 112), trans-4-[6-amino-2-(1H-pyrazol-3-yl)-9H-purin-9-yl]-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 113), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5-chloro-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 114), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[4-(trifluoromethyl)-1,3-thiazol-2-yl]cyclohexanecarboxamide (cpd 115), cis-4-(6-amino-2-iodo-9H-purin-9-yl)-N-(4-methoxy-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 116), cis-4-(6-amino-2-ethynyl-9H-purin-9-yl)-N-(4-methoxy-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 119), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-{4-[(4-aminopiperidin-1-yl)methyl]-1,3-thiazol-2-yl}cyclohexanecarboxamide (cpd 120), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(4-hydroxy-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 122), cis-4-(6-amino-2-fluoro-9H-purin-9-yl)-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 124), cis-4-(6-amino-2-fluoro-9H-purin-9-yl)-N-(4-methoxy-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 126), cis-4-(6-amino-2-fluoro-9H-purin-9-yl)-N-(4-hydroxy-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 127), cis-4-(6-amino-2-fluoro-9H-purin-9-yl)-N-(6-fluoro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 128), cis-4-[6-amino-2-(trifluoromethyl)-9H-purin-9-yl]-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 129), cis-4-[6-amino-2-(trifluoromethyl)-9H-purin-9-yl]-N-(6-fluoro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 132), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(6-fluoro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 134), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[4-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]cyclohexanecarboxamide (cpd 135), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(6-hydroxy-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 137), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-([1,3]thiazolo[5,4-c]pyridin-2-yl)cyclohexanecarboxamide (cpd 138), N-[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]-4-methyl-1,3-thiazole-2-carboxamide (cpd 139), N-[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]-1,3-benzothiazole-2-carboxamide (cpd 140), N-[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]-3-methoxybenzenesulfonamide (cpd 141), N-[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]-3-methoxybenzamide (cpd 144), 6-amino-9-{cis-4-[(4-methyl-1,3-thiazol-2-yl)carbamoyl]cyclohexyl}-9H-purine-2-carboxamide (cpd 146), 2-amino-1,3-benzothiazol-6-yl cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexanecarboxylate (cpd 159, 2-amino-1,3-benzothiazol-4-yl cis-4-(6-amino-2-fluoro-9H-purin-9-yl)cyclohexanecarboxylate (cpd 160), 2-({[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]carbonyl}amino)-1,3-benzothiazole-6-carboxamide (cpd 163(, cis-4-(6-amino-2-c-chloro-9H-purin-9-yl)-N-[4-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]-N-methylcyclohexanecarboxamide (cpd 164), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[6-(dimethylamino)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide (cpd 165), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[5-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]cyclohexanecarboxamide (cpd 166), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(4,6-difluoro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 167), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5,6-difluoro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 168), tert-butyl 2-({[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]carbonyl}amino)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carboxylate (cpd 169), cis-4-(6-amino-2-methoxy-9H-purin-9-yl)-N-(6-fluoro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 170), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5,6,7-trifluoro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 171), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(4,5,6,7-tetrahydro[1,3]thiazol[5,4-c]pyridin-2-yl)cyclohexanecarboxamide hydrochloride (cpd 172), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)cyclohexanecarboxamide (cpd 173), methyl [2-({[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]carbonyl}amino)-1,3-benzothiazol-6-yl]acetate (cpd 174), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(6-bromo-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 175), [2-({[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]carbonyl}amino)-1,3-benzothiazol-6-yl]acetic acid (cpd 176), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[6-(2-amino-2-oxoethyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide (cpd 177), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(4,4,6,6-tetramethyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)cyclohexanecarboxamide (cpd 178), cis-4-(6-amino-2-fluoro-9H-purin-9-yl)-N-(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)cyclohexanecarboxamide (cpd 179), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[6-(difluoromethoxy)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide (cpd 180), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide (cpd 181), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[5-(propan-2-yl)-4,5,6,7-tetrahydr[1,3]thiazolo[5,4-c]pyridin-2-yl]cyclohexanecarboxamide (cpd 182), cis-N-[6-(acetylamino)-1,3-benzothiazol-2-yl]-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexanecarboxamide (cpd 183), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5-cyclopropyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)cyclohexanecarboxamide (cpd 184), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)cyclohexanecarboxamide (cpd 185), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-([1,3]dioxolo[4,5-f][1,3]benzothiazol-6-yl)cyclohexanecarboxamide (cpd 186), tert-butyl (5S,8R)-2-({[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]carbonyl}amino)-5,6,7,8-tetrahydro-4H-5, 8-epiminocyclohepta[d][1,3]thiazole-9-carboxylate (cpd 187), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(6,6-difluoro-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 188), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[(5S,8R)-5,6,7,8-tetrahydro-4H-5,8-epiminocyclohepta[d][1,3]thiazol-2-yl]cyclohexanecarboxamide hydrochloride (cpd 189), cis-4-(6-amino-2-fluoro-9H-purin-9-yl)-N-(4,4,6,6-tetramethyl-4,5,6,7-tetrahydr[1,3]thiazolo[5,4-c]pyridin-2-yl)cyclohexanecarboxamide (cpd 190), cis-4-(6-amino-2-fluoro-9H-purin-9-yl)-N-(6,6-difluoro-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 191), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(5,5-dioxido-6,7-dihydro-4H-thiopyrano[4,3-d][1,3]thiazol-2-yl)cyclohexanecarboxamide (cpd 194), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(6,6-dimethyl-6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)cyclohexanecarboxamide (cpd 195), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-[5-(2-amino-2-oxoethyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]cyclohexanecarboxamide (cpd 196), 1-[cis-4-(6-amino-2-chloro-9H-purin-9-yl)cyclohexyl]-3-(3-methoxyphenyl)urea (cpd1 197), cis-4-(6-amino-2-iodo-9H-purin-9-yl)-N-(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)cyclohexanecarboxamide (cpd 198), cis-4-{6-amino-2-[(trimethylsilyl)ethynyl]-9H-purin-9-yl}-N-(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)cyclohexanecarboxamide (cpd 199), cis-4-(6-amino-2-fluoro-9H-purin-9-yl)-N-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)cyclohexanecarboxamide (cpd 200), cis-4-(6-amino-2-ethynyl-9H-purin-9-yl)-N-(5-methyl-4,5,6,7-tetrahydro [1,3]thiazolo[5,4-c]pyridin-2-yl)cyclohexanecarboxamide (cpd 201), cis-4-(4-amino-1H-imidazo [4,5-c]pyridin-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)cyclohexanecarboxamide (cpd 204), cis-4-(6-amino-2-chloro-9H-purin-9-yl)-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 205), 4-(6-amino-2-fluoro-9H-purin-9-yl)-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide (cpd 206).

Metadata:
- Claim Count in Document: 3.0
- Percentile: 99.0
- Lexical Diversity: 1.52632
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12678806', '13377854', '14874513', '15335619', '13780557']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8165451082045299
- 35 USC 102 Novelty (BERT): 0.5005212747863454
- Combined Prediction Score: 0.7849427248627114
- Mean Citation Score: 270.152288
- Max Citation Score: 281.84406
- Similarity Product: 217.20587133595347

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test