PATENT CLAIM ANALYSIS

Application Number: 15876698
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "278000"]

Abstract:
The present invention provides, in part, heterocyclic spiro compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

Claim (Index 17):
A compound of  claim 1  selected from the group consisting of:\n 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[(4-fluorophenyl)sulfonyl]-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate; \n 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(tetrahydro-2H-pyran-3-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate; \n 1-[({4-[(4-fluorophenyl)sulfonyl]-1-oxa-4,9-diazaspiro[5.5]undec-9-yl}carbonyl)oxy]pyrrolidine-2,5-dione; \n 1,1,1,3,3,3-hexafluoropropan-2-yl (3R)-3-[methyl(phenylsulfonyl)amino]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; \n N-[(3R)-8-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-yl]-N-methylbenzenesulfonamide; \n 1,1,1,3,3,3-hexafluoropropan-2-yl 3-(4-cyanophenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; \n 1,1,1,3,3,3-hexafluoropropan-2-yl 2-{[6-(difluoromethyl)pyridin-3-yl]oxy}-7-azaspiro[3.5]nonane-7-carboxylate; \n 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(pyrazin-2-ylsulfonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate; \n 1,1,1,3,3,3-hexafluoropropan-2-yl (3R)-3-[(phenylsulfonyl)amino]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; \n 1-cyclopropyl-N-[(3R)-8-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-yl]-N-methylmethanesulfonamide; \n 1,1,1,3,3,3-hexafluoropropan-2-yl (3R)-3-{[(cyclopropylmethyl)sulfonyl](methyl)amino}-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; \n 1,1,1,3,3,3-hexafluoropropan-2-yl 3-[methyl(1,3-thiazol-2-ylsulfonyl)amino]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; \n 1,1,1,3,3,3-hexafluoropropan-2-yl 3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; and \n 1-{[(2-{[6-(difluoromethyl)pyridin-3-yl]oxy}-7-azaspiro[3.5]non-7-yl)carbonyl]oxy}pyrrolidine-2,5-dione, \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 86.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15874987', '15221658', '14902324', '15808242', '11127878']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8117356801833814
- 35 USC 102 Novelty (BERT): 0.551819368996918
- Combined Prediction Score: 0.785744049064735
- Mean Citation Score: 371.852396
- Max Citation Score: 404.64084
- Similarity Product: 340.8390360479021

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test