PATENT CLAIM ANALYSIS

Application Number: 15915554
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["435", "007920"]

Abstract:
Methods and kits are provided for amplifying and detecting misfolded proteins from samples, for example, from patients having Alzheimer's Disease, Parkinson's Disease, and the like. For example, a method for determining a presence of soluble, misfolded protein in a sample may include contacting the sample with a monomeric, folded protein to form an incubation mixture; conducting an incubation cycle two or more times effective to form an amplified portion of misfolded protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded protein; physically disrupting the incubation mixture effective to break up at least a portion of any protein aggregate present; and determining the presence of the soluble, misfolded protein in the sample by detecting at least a portion of the soluble, misfolded protein. The monomeric, folded protein and the soluble, misfolded protein may exclude prion protein (PrP) and isoforms thereof.

Claim (Index 2):
The method of  claim 1 :\n further comprising contacting an indicator of the soluble, misfolded protein to the incubation mixture, the indicator of the soluble, misfolded protein being characterized by an indicating state in the presence of the soluble, misfolded protein and a non-indicating state in the absence of the soluble, misfolded protein; and wherein the determining the presence of the soluble, misfolded protein in the sample comprises detecting the indicating state of the indicator of the soluble, misfolded protein.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 90.0
- Lexical Diversity: 2.24675
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14852471', '12177012', '13833008', '15424444', '14330445']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5805500551229152
- 35 USC 102 Novelty (BERT): 0.6578297917427244
- Combined Prediction Score: 0.5882780287848962
- Mean Citation Score: 334.639886
- Max Citation Score: 699.6428
- Similarity Product: 608.6150515483141

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test