PATENT CLAIM ANALYSIS

Application Number: 15912700
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["514", "080000"]

Abstract:
The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, migraine and other headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis, and Parkinson's disease.

Claim (Index 31):
The compound according to  claim 1 , selected from compounds of Formula Ic and pharmaceutically acceptable salts, solvates, hydrates, and N-oxides thereof: wherein:\n R 1  and R 6  are each independently selected from: H, and C 1 -C 6  alkyl; \n X is NR 7  and Y is CC(O)N(R 8 )R 9 ; or \n X is CC(O)N(R 8 )R 9  and Y is NR 7 , \n R 7  is \u2014R 10 \u2014R 11 \u2014R 12 \u2014R 13 ; wherein: \n R 10  is selected from: C 1 -C 6  alkylene, heteroarylene, and heterocyclylene; or R 10  is absent; \n R 11  is selected from: \u2014C(O)NH\u2014 and C 1 -C 6  alkylene; or R 11  is absent; \n R 12  is C 1 -C 6  alkylene; or R 12  is absent; and \n R 13  is selected from: C 1 -C 6  alkyl, aryl, C 3 -C 7  cycloalkyl, heteroaryl, heterocyclyl, and hydroxyl; wherein said C 1 -C 6  alkyl, aryl, and heteroaryl are each optionally substituted with one or two substituents selected from: C 1 -C 6  alkoxy, C 1 -C 6  alkyl, C 1 -C 6  alkylamino, C 1 -C 6  alkylsulfonyl, amino, C 3 -C 7  cycloalkyl, cyano, C 2 -C 8  dialkylamino, C 1 -C 6  haloalkyl, halogen, and hydroxyl; \n R 8  is \u2014R 14 \u2014R 15 \u2014R 16 \u2014R 17 ; wherein: \n R 14  is selected from: C 1 -C 6  alkylene, C 3 -C 7  cycloalkenylene, C 3 -C 7  cycloalkylene, heteroarylene, and heterocyclylene; wherein said C 1 -C 6  alkylene and heterocyclylene are each optionally substituted with one or more substituents selected from: C 1 -C 6  alkoxycarbonyl, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, aryl, carboxy, heteroaryl, heterocyclyl, and hydroxyl; wherein said C 1 -C 6  alkyl and aryl are optionally substituted with one substituent selected from: C 1 -C 6  alkoxy, aryl, halogen, heteroaryl, and hydroxyl; or R 14  is absent; \n R 15  is selected from: \u2014C(O)NH\u2014, \u2014C(O)\u2014, \u2014C(O)O\u2014, C 1 -C 6  alkylene, C 3 -C 7  cycloalkylene, heteroarylene, and heterocyclylene; wherein said heterocyclylene is optionally substituted with C 1 -C 6  alkyl; or R 15  is absent; \n R 16  is C 1 -C 6  alkylene; or R 16  is absent; and \n R 17  is selected from: H, C 1 -C 6  alkoxy, C 1 -C 6  alkyl, C 1 -C 6  alkylamino, C 1 -C 6  alkylcarboxamide, C 2 -C 6  alkynyl, ureyl, amino, aryl, arylamino, arylcarbonyl, aryloxy, carbo-C 1 -C 6 -alkoxy, carboxamide, carboxy, cyano, C 3 -C 7  cycloalkyl, C 5 -C 11  bicycloalkyl, C 3 -C 7  cycloalkylamino, C 2 -C 8  dialkylamino, C 2 -C 8  dialkylsulfonamide, C 1 -C 6  haloalkyl, heteroaryl, heteroaryloxy, heterobicyclyl, heterocyclyl, hydroxyl, and phosphonooxy; wherein said C 1 -C 6  alkylamino, amino, aryl, arylamino, aryloxy, C 5 -C 11  bicycloalkyl, C 3 -C 7  cycloalkyl, C 3 -C 7  cycloalkylamino, heteroaryl, heterobicyclyl, heterocyclyl, and ureyl are each optionally substituted with one or more substituents selected from: C 1 -C 6  alkoxy, C 1 -C 6  alkoxycarbonyl, C 1 -C 6  alkyl, C 1 -C 6  alkylsulfonyl, amino, aryl, carboxy, cyano, C 3 -C 7  cycloalkyl, C 2 -C 8  dialkylamino, C 1 -C 6  haloalkoxy, C 1 -C 6  haloalkyl, halogen, heteroaryl, heterocyclyl, and hydroxyl; and \n R 9  is selected from H, C 1 -C 6  alkyl, and C 3 -C 7  cycloalkyl; or \n R 8  and R 9  together with the nitrogen atom to which they are both bonded form a group selected from: heterocyclyl and heterobicyclyl, each optionally substituted with one or more substituents selected from: C 1 -C 6  alkoxy, C 1 -C 6  alkyl, aryl, carbo-C 1 -C 6 -alkoxy, C 1 -C 6  haloalkyl, halogen, heteroaryl, heteroaryloxy, heterocyclyl, and hydroxyl; wherein said aryl, C 1 -C 6  alkyl, and heteroaryl are optionally substituted with one substituent selected from: C 3 -C 7  cycloalkyl, C 1 -C 6  alkoxy, halogen, and hydroxyl.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 90.0
- Lexical Diversity: 1.96809
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14956586', '15427303', '14001132', '13616918', '13392074']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8868431874883427
- 35 USC 102 Novelty (BERT): 0.7406152315045954
- Combined Prediction Score: 0.872220391889968
- Mean Citation Score: 842.060666
- Max Citation Score: 879.3344
- Similarity Product: 814.2651211090088

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test