PATENT CLAIM ANALYSIS

Application Number: 16094000
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["546", "084000"]

Abstract:
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that modulate (e.g., agonize or partially agonize) NLRP3 and TLR7 and/or TLR8 that are useful, e.g., for treating a condition, disease or disorder in which a decrease in NLRP3 and TLR7 and/or TLR8 activities (e.g., a condition, disease or disorder associated with repressed or impaired NLRP3 and TLR7 and/or TLR8 signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Claim (Index 179):
A compound having formula (I), or a pharmaceutically acceptable salt thereof: wherein: R 1  is X\u2014R 5 , wherein X is unbranched C 2-6  alkylene or \u2014O(unbranched C 2-6  alkylene)-, and R 5  is hydrogen, \u2014OH, C 1-4  alkoxy, \u2014C 1-4  alkoxy, CO 2 R a ; \u2014CONR b R c , cyano, or \u2014NR b R c ; R 2  is: (i) hydrogen; (ii) unsubsituted, unbranched C 1-6  alkyl; (iii) C 1-6  haloalkyl; or (iv) heteroalkyl, which includes from 3-8 chain atoms, wherein from 1-2 internal chain atoms are heteroatoms that are independently selected from O and S; wherein: when two heteroatoms are present in the chain, the two heteroatoms must be separated by at least one chain carbon atom; and heteroalkyl is optionally substituted with from 1-4 substituents independently selected from F, C 1-4  alkoxy, and C 1-4  haloalkoxy; R 3  and R 4  are each independently selected from the group consisting of: (i) hydrogen; (ii) cyano; (iii) C 1-4  alkyl; (iv) C 1-4  haloalkyl; (v) C 1-4  alkoxy; and (vi) C 1-4  haloalkoxy; provided that one of R 3  and R 4  is other than hydrogen; R a  is: (i) H; (ii) C 1-6  alkyl optionally substituted with from 1-2 substituents independently selected from \u2014OH, \u2014NH 2 , \u2014NH(C 1-3  alkyl), \u2014N(C 1-3  alkyl) 2 , \u2014N(H)(C(\u2550O)C 1-3  alkyl), or cyano; (iii) C 3-6  cycloalkyl optionally substituted with from 1-4 substituents independently selected from C 1-6  alkyl, C 1-4  haloalkyl, F, Cl, Br, \u2014OH, C 1-4  alkoxy, and C 1-4  haloalkoxy; or (iv) benzyl, wherein the phenyl portion is optionally substituted with from 1-4 substituents independently selected from C 1-6  alkyl, C 1-4  haloalkyl, F, Cl, Br, \u2014OH, C 1-4  alkoxy, C 1-4  haloalkoxy, cyano, CO 2 (C 1-6  alkyl); \u2014CONR d R e , and \u2014NR d R e ; each occurrence of R b  and R c  is independently selected from the group consisting of: H, C 1-4  alkyl, \u2014C(O)(C 1-4  alkyl), \u2014C(O)O(C 1-4  alkyl), \u2014S(O) 1-2 (R f ), \u2014C(O)NR d R e , \u2014OH, and C 1-4  alkoxy; or R b  and R c , together with the nitrogen atom to which each is attached forms heterocyclyl including from 3-10 ring atoms, wherein from 1-3 ring atoms are each independently selected from the group consisting of N(R g ), O, and S, and wherein the heterocyclyl is optionally further substituted with from 1-4 R h , each occurrence of R d  and R e  is independently selected from the group consisting of: H and C 1-4  alkyl; each occurrence of R f  is independently selected from the group consisting of: C 1-6  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, C 1-4  haloalkoxy, phenyl optionally substituted with from 1-3 R m , and heteroaryl including from 3-10 ring atoms, wherein from 1-3 ring atoms are each independently selected from the group consisting of nitrogen, oxygen and sulfur, wherein the heteroaryl is optionally substituted with from 1-3 R m ; each occurrence of R g  is independently selected from the group consisting of: H, C 1-4  alkyl, \u2014C(O)(C 1-4  alkyl), \u2014C(O)O(C 1-4  alkyl), \u2014C(O)NR j R k , \u2014S(O) 1-2 R h , \u2014OH, and C 1-4  alkoxy; each occurrence of R h  is independently selected from the group consisting of: C 1-6  alkyl, C 1-4  haloalkyl, F, \u2014OH, C 1-4  alkoxy, C 1-4  haloalkoxy, CO 2 R a ; \u2014CONR j R k , and \u2014NR j R k ; and each occurrence of R m  is independently selected from the group consisting of: C 1-6  alkyl, C 1-4  haloalkyl, F, Cl, Br, \u2014OH, C 1-4  alkoxy, C 1-4  haloalkoxy, cyano, CO 2 R a ; \u2014CONR d R e , and \u2014NR d R e .

Metadata:
- Claim Count in Document: 31.0
- Percentile: 97.0
- Lexical Diversity: 2.14062
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15898258', '14386747', '12310303', '16093990', '14336852']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7872621459239879
- 35 USC 102 Novelty (BERT): 0.5260387098939782
- Combined Prediction Score: 0.7611398023209869
- Mean Citation Score: 270.686064
- Max Citation Score: 347.0156
- Similarity Product: 216.46966867418288

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test