PATENT CLAIM ANALYSIS

Application Number: 16129199
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "254050"]

Abstract:
The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Claim (Index 16):
The compound according to  claim 1  or a pharmaceutically acceptable salt thereof, wherein the compound is selected from a group consisting of:\n 1-(4-((4\u2032-((2-hydroxyethyl)sulfonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 1-(4-((4\u2032-((4,4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide \n (R)-1-(4-((4\u2032-((4,4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 1-(4-(4-(5-(2-hydroxypropan-2-yl)pyridin-2-yl)benzyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 1-(4-(4-(5-(2-hydroxypropan-2-yl)-6-methylpyridin-2-yl)benzyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 1-(4-(4-(5-(2-hydroxypropan-2-yl)pyridin-2-yl)benzyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-(4-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)benzyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 1-(4-(4-(2-(2-hydroxypropan-2-yl)pyridin-4-yl)benzyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-(piperazine-1-carbonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-(piperazine-1-carbonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-(4-(6-(piperazine-1-carbonyl)pyridin-3-yl)benzyl)phenyl)-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-(4-(5-(piperazine-1-carbonyl)pyridin-2-yl)benzyl)phenyl)-1H-pyrazole-3-carboxamide; \n 1-(4-((4\u2032-(3-(hydroxymethyl)piperazine-1-carbonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n (R)-1-(4-((4\u2032-(3-(hydroxymethyl) piperazine-1-carbonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-(3-methylpiperazine-1-carbonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n (S)-5-methyl-1-(4-((4\u2032-(3-methylpiperazine-1-carbonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-(azetidin-3-ylcarbamoyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-(4-(6-(piperazin-1-ylmethyl)pyridin-3-yl)benzyl)phenyl)-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-(4-(2-(piperazin-1-ylmethyl)pyridin-4-yl)benzyl)phenyl)-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-(4-(5-(piperazin-1-ylmethyl)pyridin-2-yl)benzyl)phenyl)-1H-pyrazole-3-carboxamide; \n 1-(4-(4-(6-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)pyridin-3-yl)benzyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-(4-(5-((4-(oxetan-3-yl)piperazin-1-yl)methyl)pyridin-2-yl)benzyl)phenyl)-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-(4-(6-((4-methylpiperazin-1-yl)methyl)pyridin-3-yl)benzyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-(4-(5-(piperazin-1-ylmethyl)pyridin-2-yl)benzyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-(4-(6-((3-methylpiperazin-1-yl)methyl)pyridin-3-yl)benzyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n (S)-5-methyl-1-(4-(4-(6-((3-methylpiperazin-1-yl)methyl)pyridin-3-yl)benzyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-(4-(6-((3,4-dimethylpiperazin-1-yl)methyl)pyridin-3-yl)benzyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n (S)-1-(4-(4-(6-((3,4-dimethylpiperazin-1-yl)methyl)pyridin-3-yl)benzyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((2-oxa-6-azaspiro[3.4]octan-6-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3,3-difluoropyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-(((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((2-(hydroxymethyl) pyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n (R)-1-(4-((4\u2032-((2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((2-oxa-6-azaspiro[3.5]nonan-6-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3,3-dimethylpyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((2-oxa-7-azaspiro[3.5]nonan-7-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3,3-difluoropiperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4,4-dimethylpiperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4-((dimethylamino)methyl)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4-(dimethylamino)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-hydroxypyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n (R)-1-(4-((4\u2032-((3-hydroxypyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n (S)-1-(4-((4\u2032-((3-hydroxypyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4-hydroxy-4-methylpiperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-hydroxyazetidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3,5-dimethylpiperazin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-(((3R,5R)-3,5-dimethylpiperazin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-hydroxy-3-methyl pyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((5-oxa-2-azaspiro[3.4]octan-2-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-(hydroxymethyl)piperazin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n (R)-1-(4-((4\u2032-((3-(hydroxymethyl)piperazin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-fluoropyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n (R)-1-(4-((4\u2032-((3-fluoropyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((3-(methylsulfonyl)pyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((5-methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-hydroxy-3-methylpiperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4-(tert-butyl)piperazin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3,3-dimethylpiperazin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4,4-difluoropiperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((2-(hydroxymethyl)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n (S)-1-(4-((4\u2032-((2-(hydroxymethyl)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4-(hydroxymethyl)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-hydroxy-3-methylazetidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4-hydroxypiperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-(((3aR,6aS)-tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-fluoropiperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((4-methyl-1,4-diazepan-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3,4-dihydroxypyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-(((3S,4S)-3,4-dihydroxypyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-(((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((4-(methylsulfonyl)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((1,1-dioxidothiomorpholino)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3,3-difluoroazetidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-(((1R,5S)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-(((1R,5S,6r)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((4-(trifluoromethyl)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((3-(hydroxymethyl)azetidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((1-oxa-7-azaspiro[3.5]nonan-7-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((2-(hydroxymethyl) pyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n (S)-1-(4-((4\u2032-((2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((4-(dimethylamino)piperidin-1-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-(((3aR,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-(4-(4-(piperazine-1-carbonyl)bicyclo[2.2.2]octan-1-yl)benzyl)phenyl)-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-(4-(4-(4-methylpiperazine-1-carbonyl) bicyclo[2.2.2]octan-1-yl)benzyl)phenyl)-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-(4-(6-(piperazine-1-carbonyl)spiro[3.3]heptan-2-yl)benzyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-(piperazin-1-ylmethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-(4-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)benzyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((1-methylpiperidin-4-yl)oxy)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-(1-hydroxy-2-methylpropan-2-yl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-(4-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)benzyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-(N-(2-hydroxy-2-methyl propyl)sulfamoyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-((4\u2032-((2-hydroxy-2-methyl propyl)carbamoyl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-(4-(5-(N-(2-hydroxy-2-methylpropyl)sulfamoyl)pyridin-2-yl)benzyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-(4-(4-(2-hydroxypropan-2-yl)pyridin-2-yl)benzyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-(4-((1-methylpiperidin-4-yl)ethynyl)benzyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-(4-((1-hydroxycyclohexyl)ethynyl)benzyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-(4-(5-(1-hydroxy-2-methylpropan-2-yl)pyridin-2-yl)benzyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide; \n 1-(4-(4-(5-(1-hydroxy-2-methylpropan-2-yl)pyridin-2-yl)benzyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 1-(4-(4-(6-(2-hydroxypropan-2-yl)pyridazin-3-yl)benzyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 6-(4-(4-(3-carbamoyl-5-methyl-1H-pyrazol-1-yl)benzyl)phenyl)-N-(2-hydroxy-2-methylpropyl)nicotinamide; \n 1-(4-(4-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)benzyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 1-(4-(4-(2-(hydroxymethyl)pyridin-4-yl)benzyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((1-methylpyrrolidin-3-yl)oxy)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n (S)-5-methyl-1-(4-((4\u2032-((1-methylpyrrolidin-3-yl)oxy)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n 5-methyl-1-(4-((4\u2032-((1-methylpyrrolidin-3-yl)oxy)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; \n (R)-5-methyl-1-(4-((4\u2032-((1-methylpyrrolidin-3-yl)oxy)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-1H-1,2,4-triazole-3-carboxamide; and \n 1-(4-((4\u2032-(2-((2-hydroxy-2-methylpropyl)amino)propan-2-yl)-[1,1\u2032-biphenyl]-4-yl)methyl)phenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide.

Metadata:
- Claim Count in Document: 18.0
- Percentile: 97.0
- Lexical Diversity: 1.45763
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16045993', '14774839', '14774844', '12994250', '15890436']

Analysis Scores:
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- 35 USC 102 Novelty (BERT): 0.5705247592586967
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- Mean Citation Score: 340.874326
- Max Citation Score: 451.14423
- Similarity Product: 383.77205654305817

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