PATENT CLAIM ANALYSIS

Application Number: 15779929
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["548", "435000"]

Abstract:
The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

Claim (Index 18):
A norbornenone compound selected form any one of the following compounds, or a pharmaceutically acceptable salt thereof: Compound Structure Compound Name 3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2,5,6-triphenyl-4,7-methano-1H- isoindole-1,3,8(2H)-trione;   3a-Chloro-3a,4,7,7a-tetrahydro-4,7- dimethyl-2,5,6-triphenyl-4,7-methano-1H- isoindole-1,3,8(2H)-trione   3a-Iodo-3a,4,7,7a-tetrahydro-4,7-dimethyl- 2,5,6-triphenyl-4,7-methano-1H-isoindole- 1,3,8(2H)-trione   3a-Phenylthio-3a,4,7,7a-tetrahydro-4,7- dimethyl-2,5,6-triphenyl-4,7-methano-1H- isoindole-1,3,8(2H)-trione   3a-Phenylsulfinyl-3a,4,7,7a-tetrahydro- 4,7-dimethyl-2,5,6-triphenyl-4,7-methano- 1H-isoindole-1,3,8(2H)-trione   3a-Phenylsulfonyl-3a,4,7,7a-tetrahydro- 4,7-dimethyl-2,5,6-triphenyl-4,7-methano- 1H-isoindole-1,3,8(2H)-trione   3a-Bromo-4,7-dimethyl-5,6-diphenyl- 3a,4,7,7a-tetrahydro-1H-4,7- methanoisoindole-1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-(4-hydroxyphenyl)-5,6- diphenyl-4,7-methano-1H-isoindole- 1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-5,6-diphenyl-2-tri-(3,4- methylenedioxyphenyl)-4,7-methano-1H- isoindole-1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-(3,4-dihydroxyphenyl)-5,6- diphenyl-4,7-methano-1H-isoindole- 1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-(4-hydroxy-3-nitrophenyl)-5,6- diphenyl-4,7-methano-1H-isoindole- 1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-(4-(2-(2-(2- methoxyethoxy)ethoxy)ethoxy)phenyl)- 5,6-diphenyl-4,7-methano-1H-isoindole- 1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-(4-(2-methoxy(2- polyethoxy)phenyl)-5,6-diphenyl-4,7- methano-1H-isoindole-1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-(4-(2,3,4,6-tetra-O-acetyl-\u03b2-D- glucopyranosyloxy)phenyl)-5,6-diphenyl- 4,7-methano-1H-isoindole-1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2,5,6-tri-(4-(2-(2-(2- methoxyethoxy)ethoxy)ethoxy)phenyl)- 4,7-methano-1H-isoindole-1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-(2-acetoxyethyl)-5,6-diphenyl- 4,7-methano-1H-isoindole-1,3,8(2H)-trione   2,5-Dioxopyrrolidin-1-yl 3-(3a-bromo-4,7- dimethyl-1,3,8-trioxo-5,6-diphenyl- 1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)propanoate   tert-Butyl (2-(3-((4S,7R)-3a-bromo-4,7- dimethyl-1,3,8-trioxo-5,6-diphenyl- 3a,4,7,7a-tetrahydro-1H-4,7- methanoisoindol-2(2H)- yl)propanamido)ethyl)carbamate   2-(3-(a-Bromo-4,7-dimethyl-1,3,8-trioxo- 5,6-diphenyl-1,3,3a,4,7,7a-hexahydro-2H- 4,7-methanoisoindol-2- yl)propanamido)ethan-1-aminium trifluoroacetate and chloride   tert-Butyl (2-(3a-bromo-4,7-dimethyl-1,3,8- trioxo-5,6-diphenyl-3a,4,7,7a-tetrahydro- 2H-4,7-methanoisoindol-2- yl)ethyl)carbamate   2-(3a-Bromo-4,7-dimethyl-1,3,8-trioxo-5,6- diphenyl-2H-4,7-methanoisoindolin-2- yl)ethan-1-aminium 2,2,2- trifluoroacetate, chloride, and bromide   tert-Butyl (2-(3a-bromo-4,7-dimethyl-1,3,8- trioxo-5,6-diphenyl-3a,4,7,7a-tetrahydro- 1H-4,7-methanoisoindol-2(2H)-yl)ethyl)(2- ((tert- butoxycarbonyl)amino)ethyl)carbamate   2-(2-(2-Aminoethyl)aminoethyl)-3a-bromo- 3a,4,7,7a-tetrahydro-4,7-dimethyl-5,6- diphenyl-4,7-methano-1H-isoindole- 1,3,8(2H)-trione bis-trifluoroacetate salt   N-(2-Hydroxy-1,1- bis(hydroxymethyl)ethyl)-3-(3a-bromo-4,7- dimethyl-1,3,8-trioxo-5,6-diphenyl- 3a,4,7,7a-tetrahydro-1H-4,7- methanoisoindol-2(2H)-yl)propanamide   tert-Butyl (5-(3a-bromo-4,7-dimethyl-1,3,8- trioxo-5,6-diphenyl-3a,4,7,7a-tetrahydro- 2H-4,7-methanoisoindol-2- yl)pentyl)carbamate   5-(3a-Bromo-4,7-dimethyl-1,3,8-trioxo-54,6- diphenyl-2H-4,7-methanoisoindole-2- yl)pentan-1-aminium 2,2,2-trifluoroacetate   (2S)-2-tert-butoxycarbonylamino-6-(3a- bromo-4,7-dimethyl-1,3,8-trioxo-5,6- diphenyl-1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanoic acid   (2S)-2-Amino-6-(3a-bromo-4,7-dimethyl- 1,3,8-trioxo-5,6-diphenyl-1,3,3a,4,7,7a- hexahydro-2H-4,7-methanoisoindol-2- yl)hexanoic acid trifluoroacetic acid salt   Methyl (2S)-2-tert-butoxycarbonylamino-6- (3a-bromo-4,7-dimethyl-1,3,8-trioxo-5,6- diphenyl-1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanoate   Methyl (2S)-2-amino-6-(3a-bromo-4,7- dimethyl-1,3,8-trioxo-5,6-diphenyl- 1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanoate trifluoroacetic acid salt   Ethyl (2S)-2-tert-butoxycarbonylamino-6- (3a-bromo-4,7-dimethyl-1,3,8-trioxo-5,6- diphenyl-1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanoate   Ethyl (2S)-2-amino-6-(3a-bromo-4,7- dimethyl-1,3,8-trioxo-5,6-diphenyl- 1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanoate trifluoroacetic acid salt   nPropyl (2S)-2-tert-butoxycarbonylamino- 6-(3a-bromo-4,7-dimethyl-1,3,8-trioxo-5,6- diphenyl-1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanoate   nPropyl (2S)-2-amino-6-(3a-bromo-4,7- dimethyl-1,3,8-trioxo-5,6-diphenyl- 1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanoate trifluoroacetic acid salt   N,N-Dimethyl (2S)-2-tert- butoxycarbonylamino-6-(3a-bromo-4,7- dimethyl-1,3,8-trioxo-5,6-diphenyl- 1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanamide   N,N-Dimethyl (2S)-2-amino-6-(3a-bromo- 4,7-dimethyl-1,3,8-trioxo-5,6-diphenyl- 1,3,3a,4,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanamide trifluoroacetic acid salt   tert-Butyl 6-(3a-bromo-4,7-dimethyl-1,3,8- trioxo-5,6-diphenyl-1,3,3a,4,7,7a- hexahydro-2H-4,7-methaneoisoindol-2- yl)hexanoate   6-(3a-bromo-4,7-dimethyl-1,3,8-trioxo-5,6- diphenyl-1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanoic acid   Methyl (2S)-2-tert-butoxycarbonylamino-5- (3a-bromo-4,7-dimethyl-1,3,8-trioxo-5,6- diphenyl-1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)pentanoate   Methyl (2S)-2-amino-5-(3a-bromo-4,7- dimethyl-1,3,8-trioxo-5,6-diphenyl- 1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)pentanoate trifluoroacetic acid salt   Methyl (2S)-2-acetamido-6-(3a-bromo-4,7- dimethyl-1,3,8-trioxo-5,6-diphenyl- 1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)hexanoate   (1S)-1-tert-butoxycarbonylamino-5-(3a- bromo-4,7-dimethyl-1,3,8-trioxo-5,6- diphenyl-1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)-1-(3-methyl-1,2,4- oxadiazol-5\u2032-yl)pentane   (1S)-1-amino-5-(3a-bromo-4,7-dimethyl- 1,3,8-trioxo-5,6-diphenyl-1,3,3a,4,7,7a- hexahydro-2H-4,7-methanoisoindol-2-yl)- 1-(3-methyl-1,2,4-oxadiazol-5-yl)pentane trifluoroacetic acid salt   (1S)-1-tert-butoxycarbonylamino-5-(3a- bromo-4,7-dimethyl-1,3,8-trioxo-5,6- diphenyl-1,3,3a,4,7,7a-hexahydro-2H-4,7- methanoisoindol-2-yl)-1-(5-methyl-1,3,4- oxadiazol-2-yl)pentane   (1S)-1-Amino-5-(3a-bromo-4,7-dimethyl- 1,3,8-trioxo-5,6-diphenyl-1,3,3a,4,7,7a- hexahydro-2H-4,7-methanoisoindol-2-yl)- 1-(5-methyl-1,3,4-oxadiazol-2-yl)pentane trifluoroacetic acid salt   3a,4,7,7a-Tetrahydro-7a-bromo-4,7- dimethyl-5,6-diphenyl-1H-4,7- methanoisobenzofuran-1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-(2-propyn-1-yl)-5,6-diphenyl- 4,7-methano-1H-isoindole-1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-[[1-(2-(2:3,4:6-bis-O-(1- methylethylidene)-\u03b1-D- mannopyranosyloxy)ethyl]-1H-1,2,3- triazol-4-yl]methyl-5,6-diphenyl-4,7- methano-1H-isoindole-1,3,8(2H)-trione   3a-Bromo-3a,4,7,7a-tetrahydro-4,7- dimethyl-2-[[1-(2-\u03b1-D- mannopyranosyloxy)ethyl]-1H-1,2,3- triazol-4-yl]methyl-5,6-diphenyl-4,7- methano-1H-isoindole-1,3,8(2H)-trione   2-Bromo-1,4-dimethyl-7-oxo-5,6-diphenyl- bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid   4a,7-Dibromo-1,4-dimethyl-2,3-diphenyl- 1,4,4a,8a-tetrahydro-1,4- methanonaphthalene-5,8,9-trione

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.225
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11311731', '11338587', '12643641', '10561153', '11785998']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7713834831760434
- 35 USC 102 Novelty (BERT): 0.5264669023103935
- Combined Prediction Score: 0.7468918250894785
- Mean Citation Score: 294.66267
- Max Citation Score: 354.02344
- Similarity Product: 297.27345565944194

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test