PATENT CLAIM ANALYSIS

Application Number: 15917408
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "469000"]

Abstract:
Inhibitors of EYA tyrosine phosphatase are provided herein, as well as pharmaceutical compositions and methods relating thereto.

Claim (Index 1):
A method of treating an ocular disorder in an individual, comprising:\n selecting or identifying an individual suffering from an ocular disorder selected from the group consisting of proliferative retinopathy, retinopathy of prematurity, diabetic retinopathy, age related macular degeneration, retinal vasculitis, exudative vitreoretinopathy, tumor angiogenesis, hemangiomas or tumor metastasis; and administering to the individual a compound selected from the group of compounds having the structure of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1  is selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkenyl, (cyclolalkyl)alkyl, C-amido, N-amido, S-sulfonamido, and N-sulfonamido, said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl, heterocyclylalkyl, cycloalkyl, cycloalkenyl, and (cyclolalkyl)alkyl are each optionally substituted with one or more R 1A ; each R 1A  is independently selected from the group consisting of hydroxy, halo, cyano, nitro, (C 1 -C 6 )alkyl optionally substituted with up to 5 fluoro, C 1-6  alkoxy optionally substituted with up to 5 fluoro, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, S-sulfonamido, N-sulfonamido, C-carboxy, O-carboxy, isocyanato, thiocyanato, isothiocyanato, nitro, and amino; R 2  is selected from the group consisting of H (hydrogen), halo, hydroxy, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, S-sulfonamido, N-sulfonamido, C-carboxy, O-carboxy, and C 1-6  alkyl substituted with one or more hydroxy; R 3  is selected from the group consisting of halo, hydroxy, O-carbamyl, N-carbamyl, C-amido, S-sulfonamido, N-sulfonamido, C-carboxy, amino, and C 1-6  alkyl substituted with one or more hydroxy; R 4  is selected from the group consisting of H (hydrogen), halo, C 1-6  alkyl optionally substituted with up to 5 fluoro and C 1-6  alkoxy optionally substituted with up to 5 fluoro; R 5  and R 6  are each independently selected from the group consisting of H (hydrogen), halo, cyano, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl, heterocyclylalkyl, cycloalkyl, cycloalkenyl, (cyclolalkyl)alkyl, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, S-sulfonamido, N-sulfonamido, C-carboxy, O-carboxy, isocyanato, thiocyanato, isothiocyanato, nitro, and amino, said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl, heterocyclylalkyl, cycloalkyl, cycloalkenyl, and (cyclolalkyl)alkyl each optionally substituted with one or more R 1A ; X 1  is [C(R 2A ) 2 ] n , O (oxygen), or NR 2A , or X 1  is absent; X 2  is [C(R 2A ) 2 ] n , O (oxygen), or NR 2A , or X 2  is absent; each R 2A  is independently selected from the group consisting of H (hydrogen), halo, hydroxy, O-carbamyl, N-carbamyl, C-amido, S-sulfonamido, N-sulfonamido, C-carboxy, amino, C 2-6  alkenyl, C 2-6  alkynyl, aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl, heterocyclylalkyl, cycloalkyl, cycloalkenyl, (cyclolalkyl)alkyl, C 1-6  alkyl substituted with one or more hydroxyl, and C 1-6  alkyl optionally substituted with up to 5 fluoro; each n is independently 1 or 2; Y 1  is O (oxygen), S (sulfur), or NR 2A ; and each Z is independently selected from the group consisting CR 2A , and N (nitrogen), wherein the compound is administered to the individual in an amount effective to inhibit an EYA tyrosine phosphatase but below the level effective to inhibit a cysteine catalysis-based tyrosine phosphatase.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.05556
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15648349', '14761264', '13787677', '15094733', '14378089']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8448611700149922
- 35 USC 102 Novelty (BERT): 0.7371154387181995
- Combined Prediction Score: 0.834086596885313
- Mean Citation Score: 659.262562
- Max Citation Score: 832.8393599999997
- Similarity Product: 819.8280320793913

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test