PATENT CLAIM ANALYSIS

Application Number: 16386183
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["424", "465000"]

Abstract:
Provided herein in some embodiments are pharmaceutical compositions comprising a prostacyclin (PGI2) receptor agonist selected from 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (Compound 1) and pharmaceutically acceptable salts, solvates, and hydrates thereof, as disclosed herein. In some embodiments the pharmaceutical compositions comprise a compound selected from 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (Compound 1), and pharmaceutically acceptable salts, solvates, and hydrates thereof, in an amount equivalent to a therapeutically effective amount of Compound 1, the composition having a release rate by weight of the compound in an aqueous medium that is one or more of release rates (a), (b) and (c) as disclosed herein. The compositions of the present invention are useful in the treatment of PGI2 related disorders, such as those disclosed herein.

Claim (Index 113):
A pharmaceutical composition comprising a compound selected from 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid, having the structure: or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in an amount equivalent to about 0.01 mg to about 1 mg of Compound 1,\n wherein the pharmaceutical composition is a tablet; \n wherein the composition comprises at least a first excipient and a second excipient, wherein the first excipient comprises a release modifier having a viscosity of about 2300 mPA seconds to about 3800 mPA seconds when present in an amount of about 2% in water at 20\u00b0 C. and the second excipient comprises a release modifier having a viscosity of about 75 mPA seconds to about 120 mPA seconds when present in an amount of about 2% in water at 20\u00b0 C., \n wherein the composition has a release rate by weight of the compound in an aqueous medium that is one or more of release rates (a), (b) and (c), wherein\n (a) less than or equal to about 40% by weight of the compound is released over the first two hours in the aqueous medium; \n (b) about 40% to about 60% by weight of the compound is released over the first five hours in the aqueous medium; and \n (c) more than or equal to about 80% by weight of the compound is released over the first fourteen hours in the aqueous medium, \n \n wherein the release rate is measured with USP Apparatus 1 (baskets) at 80 to 120 rpm in 400 to 600 mL of an aqueous medium at a pH of 6.3 to 7.3 at a temperature of 37\u00b0 C.\u00b10.5\u00b0 C., comprising sodium phosphate at a concentration of 0.04 to 0.06 M.

Metadata:
- Claim Count in Document: 79.0
- Percentile: 100.0
- Lexical Diversity: 2.39744
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15605108', '16150350', '11897940', '11930644', '14841428']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7212599450000804
- 35 USC 102 Novelty (BERT): 0.4915454039133222
- Combined Prediction Score: 0.6982884908914047
- Mean Citation Score: 226.473242
- Max Citation Score: 230.45815
- Similarity Product: 172.8865798846483

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test