PATENT CLAIM ANALYSIS

Application Number: 16052419
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["514", "027000"]

Abstract:
A baicalin magnesium compound and methods for preparing and extracting the same. The method for preparing the baicalin magnesium compound includes steps of preparation of a baicalin suspension, preparation of a magnesium ion-containing suspension, reaction and drying. The method for extracting the baicalin magnesium compound includes steps of pretreatment of macroporous resin, extraction, adsorption and elution, concentration and drying and purification. The methods restores the baicalin to the original form as found in radix scutellariae, and the baicalin magnesium compound may be used as a substitute for the baicalin in pharmaceutical applications. As compared to the baicalin, the baicalin magnesium has a greatly increased solubility, faster adsorption rate and higher oral bioavailability. The baicalin magnesium compound may also be easily formulated as a water-soluble injection or a powder injection. Pharmacological tests show that the baicalin magnesium compound is more pharmacologically active than the baicalin.

Claim (Index 6):
A method for preparing the baicalin magnesium compound of  claim 1 , comprising:\n a. soaking a macroporous resin in a 95 vol % ethanol solution for 20-28 hours; packing the soaked macroporous resin on a column in a wet manner to allow the 95 vol % ethanol solution to pass through macroporous resin column at a rate of 1.5-2.5 BV/h until a liquid from the macroporous resin column and water mixed at a ratio of 1:5 by volume is no longer white and cloudy; and eluting the macroporous resin column to colorless with distilled water at a flow rate of 1.5-2.5 BV/h; b. adding radix scutellariae in a 40-60 vol % ethanol solution at a weight (g)-volume (ml) ratio of 1:8-15 of the radix scutellariae to the 40-60 vol % ethanol solution; decocting under stirring at 55-65\u00b0 C. for 0.8-1.2 hours to produce a mixture; filtering the mixture to obtain a solution and a residue; repeatedly subjecting the residue to extraction 2-3 times to produce multiple extracts; and combining the multiple extracts to obtain a radix scutellariae extract; c. passing the radix scutellariae extract obtained in step B through the macroporous resin column in step A at a rate of 1.5-2.5 BV/h for adsorption; washing the macroporous resin column with water of 4-6 times the volume of a macroporous resin bed; and eluting the macroporous resin column with 45-55 vol % ethanol solution of 4-6 times the volume of the macroporous resin bed to collect a baicalin-containing eluent; d. concentrating the baicalin-containing eluent obtained in step C at 35-65\u00b0 C. under reduced pressure until a concentrate has a volume of 1-15 times the weight in grams of the radix scutellariae; and drying the concentrate to obtain a crude baicalin magnesium extract; and e. purifying the crude baicalin magnesium extract obtained in step D to produce the baicalin magnesium compound.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 96.0
- Lexical Diversity: 2.14865
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14914166', '12601236', '13884422', '11995320', '13981054']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7683122802238255
- 35 USC 102 Novelty (BERT): 0.5023475979854711
- Combined Prediction Score: 0.74171581199999
- Mean Citation Score: 227.878938
- Max Citation Score: 254.55005
- Similarity Product: 179.99589928210975

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test