PATENT CLAIM ANALYSIS

Application Number: 16107203
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["210", "634000"]

Abstract:
Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process.

Claim (Index 1):
A method of performing chromatography with gamma-irradiated chromatography resin, comprising:\n (a) providing a chromatography column containing a gamma-irradiated chromatography resin; and (b) performing at least two cycles of chromatography with the chromatography column, wherein the chromatography column is exposed to a denaturing buffer during each of the at least two cycles of chromatography, and wherein during each exposure the flow rate, volume, and concentration of the denaturing buffer are selected to substantially recover binding capacity lost due to the gamma-irradiated chromatography resin.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 96.0
- Lexical Diversity: 2.14286
- Patent Class: 210.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14598450', '14629315', '14598401', '14627559', '14645138']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7838242677248023
- 35 USC 102 Novelty (BERT): 0.6372824020417532
- Combined Prediction Score: 0.7691700811564974
- Mean Citation Score: 422.66383600000006
- Max Citation Score: 670.20746
- Similarity Product: 540.631225138334

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test