PATENT CLAIM ANALYSIS

Application Number: 15759484
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "571000"]

Abstract:
The invention relates to a method for the diagnosis of non-alcoholic steatohepatitis (NASH), for determining the activity, the stage, or the severity of NASH or for classifying a subject as a potential receiver or non receiver of a treatment of NASH using circulating miRNAs and other blood circulating markers of liver damage, e.g. alpha 2 macroglobulin, HbA1c, N-terminal pro-peptide of collagen type III, miR-34 and miR-200. It also relates to a kit for implementing the method of the invention, and the compounds for use in a method for the treatment of NASH, wherein the subject to be treated is identified, evaluated or classified according to the method of the invention.

Claim (Index 12):
The method of  claim 11 , comprising determining the level of alpha 2 macroglobulin, HbA1c, N-terminal pro-peptide of collagen type III, hsa-miR-34 and hsa-miR-200, wherein the NASH score is calculated according to the following logistic function: S = e Y 1 + e Y wherein:\n Y=k+a*A+b*B+c*C+d*D+f*F  \n wherein:\n S is the NASH score; \n A is the level of alpha 2 macroglobulin in g/L; \n B is the level of HbA1c in percent; \n C is the level of N-terminal pro-peptide of collagen type III in ng/mL; \n D is the level of hsa-miR-34 in Cq; \n F is the level of hsa-miR-200 in Cq; \n k is a number comprised between 5.26 and 36.76; \n a is a number comprised between 0.11 and 1.07; \n b is a number comprised between 0 and 1.02; \n c is a number comprised between 0 and 0.23; \n d is a number comprised between \u22120.77 and 0; \n f is a number comprised between \u22120.78 and 0.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.92308
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15550416', '11855792', '15318646', '15320208', '13387314']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7466701098687842
- 35 USC 102 Novelty (BERT): 0.5074910614026508
- Combined Prediction Score: 0.7227522050221709
- Mean Citation Score: 223.135226
- Max Citation Score: 241.80423
- Similarity Product: 151.48940139638182

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test