PATENT CLAIM ANALYSIS

Application Number: 15747410
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["424", "422000"]

Abstract:
The present invention relates to a cell-free, multi-layered medical device having bespoke, multifunctional bioactivity for the purpose of regeneration of skeletal tissues. The medical device may actively promote homing of stem cells into the medical device and promote their differentiation into the required cell type and promote de-novo tissue formation. The invention includes methods of making the medical device, uses of the medical device in promoting regeneration of the articular cartilage of a joint surface and in promoting healing and regeneration of skeletal tissues, for example, meniscal cartilage, tendon and ligament tissues and also healing of bone tissue indications such as fractures.

Claim (Index 1):
A biomimetic medical device comprising a scaffold coated in or adsorbed on its surfaces with a first layer comprising a cationic agent, the first layer being covered or coated with a second layer comprising an anionic oligosaccharide or polysulphated moiety, which is non-covalently bound to at least one or more bioactive factors selected from the groups comprising:\n (i) an agent that can stimulate stem cell differentiation and/or promote appropriate extracellular matrix formation for the tissue to be regenerated; (ii) an agent that inhibits enzymes associated with the breakdown or catabolism of extracellular matrix; and (iii) a stem cell homing or migratory factor.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 86.0
- Lexical Diversity: 1.85
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13702606', '15235466', '12195255', '14380161', '13651296']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7118843460455835
- 35 USC 102 Novelty (BERT): 0.5136668516339429
- Combined Prediction Score: 0.6920625966044194
- Mean Citation Score: 283.5594680000001
- Max Citation Score: 299.13004
- Similarity Product: 212.74292442333223

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test