PATENT CLAIM ANALYSIS

Application Number: 16221006
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["514", "277000"]

Abstract:
The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the CIC-1 ion channel.

Claim (Index 14):
The method according to  claim 11 , wherein the compound is a compound of Formula (II.4): wherein:\n R 1  is selected from the group consisting of H, deuterium, F, Cl, Br and I; \n R 3  is selected from the group consisting of deuterium, tritium, F, Cl, Br, I, CN, CF 3 , CCl 3 , CHF 2 , CHCl 2 , CH 2 F, CH 2 Cl, OCF 3 , OCCl 3  and isocyanide; \n R 4  is selected from the group consisting of H, deuterium, C 1-5  alkyl, C 2-5  alkenyl, C 2-5  alkynyl, C 3-5  cycloalkyl, C 5  cycloalkenyl, each of which may be optionally substituted with one or more, identical or different, substituents R 7 ; \n R 5  is selected from the group consisting of H, C 1-5  alkyl optionally substituted with one or more, identical or different, substituents R 8 , C 2-5  alkenyl, C 2-5  alkynyl, C 3-6  cycloalkyl optionally substituted with one or more, identical or different, substituents R 8 , phenyl optionally substituted with one or more, identical or different, substituents R 9  and benzyl optionally substituted with one or more, identical or different, substituents R 9 ; \n R 6  is independently selected from the group consisting of H, deuterium, tritium, F, Cl, Br, I, CN, isocyanide, C 1-5  alkyl, C 2-5  alkenyl, C 2-5  alkynyl, C 3-5  cycloalkyl, C 5  cycloalkenyl, O\u2014C 1-5  alkyl, O\u2014C 2-5  alkenyl, O\u2014C 2-5  alkynyl, O\u2014C 3-5  cycloalkyl, O\u2014C 5  cycloalkenyl, \u2014C(\u2550O)\u2014C 1-5  alkyl, \u2014C(\u2550O)\u2014C 2-5  alkenyl, \u2014C(\u2550O)\u2014C 2-5  alkynyl, \u2014C(\u2550O)\u2014C 3-5  cycloalkyl, \u2014CH 2 \u2014O\u2014C 1-3  alkyl and \u2014CH 2 \u2014S\u2014C 1-3  alkyl, and wherein C 1-5  alkyl, C 2-5  alkenyl, C 2-5  alkynyl, C 3-5  cycloalkyl, C 5  cycloalkenyl, O\u2014C 1-5  alkyl, O\u2014C 2-5  alkenyl, O\u2014C 2-5  alkynyl, O\u2014C 3-5  cycloalkyl, O\u2014C 5  cycloalkenyl, \u2014C(\u2550O)\u2014C 1-5  alkyl, \u2014C(\u2550O)\u2014C 2-5  alkenyl, \u2014C(\u2550O)\u2014C 2-5  alkynyl, \u2014C(\u2550O)\u2014C 3-5  cycloalkyl, \u2014CH 2 \u2014O\u2014C 1-3  alkyl and \u2014CH 2 \u2014S\u2014C 1-3  alkyl may be optionally substituted with one or more halogens; \n R 7  is independently selected from the group consisting of deuterium, tritium, F, Cl, Br, I, CN, isocyanide, O\u2014C 1-3  alkyl optionally substituted with one or more, identical or different, substituents R 8 , S\u2014C 1-3  alkyl optionally substituted with one or more, identical or different, substituents R 8 , CH 2 \u2014O\u2014C 1-3  alkyl optionally substituted with one or more, identical or different, substituents R 8  and CH 2 \u2014S\u2014C 1-3  alkyl optionally substituted with one or more, identical or different, substituents R 8 ; \n R 8  is independently selected from the group consisting of deuterium and F; \n R 9  is independently selected from the group consisting of deuterium, methoxy, nitro, cyano, Cl, Br, I and F, \n m is an integer 0, i or 2; and \n n is an integer 0, 1, 2 or 3.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 98.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15842823', '14580045', '13651312', '15232892', '11698781']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7662549295925577
- 35 USC 102 Novelty (BERT): 0.6918241584686825
- Combined Prediction Score: 0.7588118524801701
- Mean Citation Score: 419.942236
- Max Citation Score: 793.0178
- Similarity Product: 669.3713872259617

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test