PATENT CLAIM ANALYSIS

Application Number: 16289776
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-06
Patent Classification: ["435", "006100"]

Abstract:
A method of determining a macromolecular analyte in a sample suspected of containing the macromolecular analyte is disclosed. The sample and a conjugate reagent comprising a small molecule and a binding partner for the macromolecular analyte are combined in a medium. The conjugate reagent and a labeled binding partner for the small molecule are combined. The conjugate reagent or the medium is examined for an amount of labeled binding partner for the small molecule that is bound to the small molecule, which is related to the amount of the macromolecular analyte in the sample.

Claim (Index 1):
A method of determining a macromolecular analyte in a sample suspected of containing the macromolecular analyte, the method comprising:\n (a) combining in a medium the sample and a conjugate reagent comprising a small molecule and a binding partner for the macromolecular analyte, (b) combining the conjugate reagent and a labeled binding partner for the small molecule, and (c) examining the conjugate reagent or the medium for an amount of labeled binding partner for the small molecule that is bound to the small molecule and relating the amount thereof to the amount of the macromolecular analyte in the sample, wherein said macromolecular analyte, when present, binds to the binding partner for the macromolecular analyte and has a size or a shape or a combination of both size and shape that hinders the ability of the binding partner for the small molecule to bind to the small molecule when the small molecule is part of the reagent that also comprises the binding partner that is specific for the macromolecular substance, wherein the macromolecular analyte has a molecular weight of at least 5000 and is selected from the group consisting of antibodies, enzymes, hormones, polynucleotides, and carbohydrates, and wherein the small molecule is an organic molecule that has a molecular weight in the range of from 100 to 2000, comprises functional groups that are reactive with the binding partner for the macromolecular analyte and is bound to the binding partner for the macromolecular analyte.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 99.0
- Lexical Diversity: 2.53846
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11970658', '11359666', '11268323', '12491394', '15319235']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6418965774643833
- 35 USC 102 Novelty (BERT): 0.5009063929724531
- Combined Prediction Score: 0.6277975590151903
- Mean Citation Score: 252.93627800000004
- Max Citation Score: 269.43185
- Similarity Product: 202.37721725285053

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test