PATENT CLAIM ANALYSIS

Application Number: 16204642
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["435", "006120"]

Abstract:
The invention provides methods for determining the MSI status of a patient by liquid biopsy with sample preparation using hybrid capture and non-unique barcodes. In certain aspects, the invention provides a method of detecting microsatellite instability (MSI). The method includes obtaining cell-free DNA (cfDNA) from a sample of blood or plasma from a patient and sequencing portions of the cfDNA to obtain sequences of a plurality of tracts of nucleotide repeats in the cfDNA. A report is provided describing an MSI status in the patient when a distribution of lengths of the plurality of tracts has peaks that deviate significantly from peaks in a reference distribution.

Claim (Index 2):
The method of  claim 1 , wherein the reference distribution is from a matched normal DNA sample.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 98.0
- Lexical Diversity: 1.66667
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13860422', '14852664', '11576597', '10505725', '11612567']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6644039374237352
- 35 USC 102 Novelty (BERT): 0.5199848932872319
- Combined Prediction Score: 0.6499620330100848
- Mean Citation Score: 295.75576999999987
- Max Citation Score: 323.45447
- Similarity Product: 222.8122432214296

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test