PATENT CLAIM ANALYSIS

Application Number: 15990860
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "023000"]

Abstract:
The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline, or in the form of amorphous/crystalline solid dispersions/solutions with pharmaceutically acceptable polymers and preparation process thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition.

Claim (Index 3):
A process according to  claim 1 , wherein reduction is carried out using silanes such as e.g. triethylsilane, tripropylsilane, triisopropylsilane, or diphenylsilane, sodium borohydride, sodium cyanoborohydride, zinc borohydride, borane complexes, lithium aluminum hydride, diisobutylaluminum hydride, vitride and the like; Lewis acid selected from aluminum chloride, boron trifluoride etherate (BF 3 .Et 2 O), copper (II) triflate, iron (III) chloride, tin (II) chloride, tin tetrachloride, zinc chloride and the like; or Bronsted acids such as hydrochloric acid, toluenesulfonic acid, trifluoroacetic acid or acetic acid;\n coupling is carried out using alkyllithium selected from n-, sec-, and tert-butyl lithium; the acid is selected from methanesulfonic acid, toluenesulfonic acid, hydrochloric acid, sulphuric acid, acetic acid, ammonium chloride and the like; the suitable reagent for introducing the hydroxyl protecting group is selected from acetic anhydride, acetyl chloride, propionic anhydride, propanoyl chloride, benzoic anhydride, benzoyl chloride, 4-nitrobenzoyl chloride; the reagent pair is thiourea/AlCl 3  reagent pair; demethylation is carried out using reagents selected from dodecanethiol, decanethiol, cyclohexane thiol, cyclopentane thiol, cyclobutane thiol, thiophenol, methanethiol, ethanethiol, 1-propanethiol, 2-propanethiol, n-butanethiol, tert-butanthiol, furan-2-yl-methanethiol, ethandithiol, 1,2-propanedithiol, 1,3-propanedithiol, 1,3-butanedithiol, 1,4-butanedithiol.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.85714
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15105620', '15430409', '15571112', '15553843', '15759562']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7935504897593485
- 35 USC 102 Novelty (BERT): 0.5194304361825028
- Combined Prediction Score: 0.766138484401664
- Mean Citation Score: 273.46067400000004
- Max Citation Score: 305.99005
- Similarity Product: 210.52953298802376

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test