PATENT CLAIM ANALYSIS

Application Number: 15757415
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-04
Patent Classification: ["435", "029000"]

Abstract:
There is described an isolated 3-dimensional liver spheroid wherein said spheroid has: increased ATP content as compared to a 3-dimensional liver spheroid cultured in Complete William's E medium alone; the same or increased activity of cytochrome P450 1A1 and cytochrome P450 1B1 as compared to a 3-dimensional liver spheroid cultured in Complete William's E medium alone; and increased albumin secretion as compared to a 3-dimensional liver spheroid cultured in William's E medium alone.

Claim (Index 13):
An in vitro method for assessing the response of a 3-dimensional liver spheroid and a 3-dimensional lung epithelial cell to an agent, the method comprising:\n (i) contacting the co-culture according to  claim 5  or the 3-dimensional organ culture system according to  claim 6 , or the 3-dimensional multi-organ culture system according to  claim 7  or  9  with at least one agent; and (ii) measuring one or more responses of the co-culture or the 3-dimensional organ culture system or the 3-dimensional multi-organ culture system after contact with the at least one agent; wherein a difference in the one or more responses before and after contact with the at least one agent is indicative that the agent modulates the response of the cell; preferably, wherein step (ii) comprises measuring the penetration of the at least one agent into the 3-dimensional lung epithelial cell; and/or, comprising the further step of: (iii) measuring the bio-activation of the at least one agent in the 3-dimensional liver spheroid; wherein the measurements in steps (ii) and (iii) are carried out simultaneously or wherein the measurement in step (iii) is carried out after the measurement in step (ii); and/or wherein the agent is an aerosol, suitably, wherein the aerosol is or is derived from smoke, suitably, cigarette smoke.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 90.0
- Lexical Diversity: 1.95122
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12520008', '15134498', '12542505', '13882429', '12177017']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5752264386044235
- 35 USC 102 Novelty (BERT): 0.5030611190416208
- Combined Prediction Score: 0.5680099066481432
- Mean Citation Score: 224.67701
- Max Citation Score: 240.10646
- Similarity Product: 151.7138724442935

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test