PATENT CLAIM ANALYSIS

Application Number: 15757027
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-10
Patent Classification: ["546", "197000"]

Abstract:
The present invention provides an improved process for the preparation of N-protected ((3S,4R)-4-(4-fluorophenyl)piperidin-3-yl)methanol (compound (A)) and further its transformation to Paroxetine and its pharmaceutically acceptable salts. The process comprises reaction of compound (II) with amido-malonate compound (C) in the presence of a chiral catalyst and optionally a dehydrating agent to obtain compound (B); followed by reduction of (B) in the presence of a reducing agent to provide compound (A).

Claim (Index 1):
A process for the preparation of N-protected ((3S,4R)-4-(4-fluorophenyl)piperidin-3-yl)methanol (A) of the following formula, wherein R is selected from H, C 1 -C 10  straight and/or branched alkyl, benzyl; comprising;\n (i) reacting the compound (II) of the following formula; \n with amido-malonate compound (C) represented by the following formula; \u2003wherein Rx is H, C 1 -C10 straight and/or branched alkyl; in the presence of a chiral catalyst and optionally a dehydrating agent;\n (ii) reducing the compound (B) of the following formula obtained from stage (i); \n in the presence of a reducing agent.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 90.0
- Lexical Diversity: 1.81132
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14891028', '10488842', '11892785', '15322581', '13119743']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.755948184450116
- 35 USC 102 Novelty (BERT): 0.4938333496824599
- Combined Prediction Score: 0.7297367009733504
- Mean Citation Score: 212.217208
- Max Citation Score: 231.76048
- Similarity Product: 161.35195313415528

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test