PATENT CLAIM ANALYSIS

Application Number: 16402912
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-08
Patent Classification: ["514", "275000"]

Abstract:
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

Claim (Index 1):
A method, comprising administering to a subject a compound having a Formula (I) or a salt thereof, wherein:\n R 2  and R 4  are different and independently are each phenyl substituted with one or more of the same or different R 8  groups; \n R 5  is fluoro; \n R 8  is selected from R a , R b , R a  substituted with one or more of the same or different R a  or R b , OR a  substituted with one or more of the same or different R a , \u2014(CH 2 ) m \u2014R b , \u2014(CHR a ) m \u2014R b , \u2014O\u2014(CH 2 ) m \u2014R b , \u2014O\u2014(CHR a ) m \u2014R b , \u2014C(O)NH\u2014(CH 2 ) m \u2014R b , \u2014C(O)NH\u2014(CHR a ) m \u2014R b , \u2014O\u2014(CH 2 ) m \u2014C(O)NH\u2014(CH 2 ) m \u2014R b \u2014O\u2014(CHR a ) m \u2014C(O)NH\u2014(CHR a ) m \u2014R b , \u2014NH\u2014(CH 2 ) m \u2014R b  \u2014NH\u2014(CHR a ) m \u2014R b ; \n each R a  is independently selected from (C1-C6) alkyl, (C3-C8) cycloalkyl, cyclohexyl, (C4-C11) cycloalkylalkyl, (C5-C10) aryl, phenyl, (C6-C16) arylalkyl, benzyl, 3-8 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, 4-11 membered cycloheteroalkylalkyl, 5-10 membered heteroaryl, or 6-16 membered heteroarylalkyl; \n each R b  is independently selected from OR a , (C1-C3) haloalkyloxy, \u2014NR c R c , halogen, \u2014CF 3 , \u2014CN, \u2014OCN, \u2014SCN, \u2014NO, NO 2 , \u2014N 3 , \u2014S(O)R a , \u2014S(O) 2 R a , \u2014S(O) 2 OR a , \u2014S(O) 2 NR c R c , \u2014OS(O)R a , \u2014OS(O) 2 R a , \u2014OS(O) 2 OR a , \u2014OS(O) 2 NR c R c , \u2014C(O)R a , \u2014C(O)OR a , \u2014C(O)NR c R c , \u2014C(NH)NR c R c , OC(O)R a , \u2014OC(O)OR a , \u2014OC(O)NR c R c , \u2014OC(NH)NR c R c , \u2014[NHC(O)]R a , \u2014[NHC(O)]OR a , \u2014[NHC(O)]NR c R c  or \u2014[NHC(NH)]NR c R c ; \n each R c  is independently H or R a ; \n at least one R 8  is R b ; and \n each m is independently an integer from 1 to 3.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 100.0
- Lexical Diversity: 1.6875
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13961780', '12273357', '15443145', '11539054', '14333163']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8644395631171529
- 35 USC 102 Novelty (BERT): 0.6269185727248298
- Combined Prediction Score: 0.8406874640779205
- Mean Citation Score: 586.1704599999998
- Max Citation Score: 586.8144
- Similarity Product: 540.4856900422096

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test