PATENT CLAIM ANALYSIS

Application Number: 15759177
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["544", "279000"]

Abstract:
Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR8 and pharmaceutically acceptable salts thereof, useful in treating HIV infections.

Claim (Index 9):
The method of any one of  claims 1 - 8 , wherein the TLR8 modulating compound is a compound of Formula (IV), or a pharmaceutically acceptable salt thereof, wherein: R 1  is selected from the group consisting of hydrogen, halogen, C 1-6  alkyl, CN, and OR a , wherein C 1-6  alkyl is optionally substituted with 1 to 5 R 20  groups; R 2  is selected from the group consisting of hydrogen, halogen, C 1-6  alkyl, CN, and OR a , wherein C 1-6  alkyl optionally substituted with 1 to 5 R 20  groups; R 3  is selected from the group consisting of hydrogen, halogen, C 1-6  alkyl, CN, and OR a , wherein C 1-6  alkyl is optionally substituted with 1 to 5 R 20  groups; R 11  is selected from the group consisting of hydrogen, C 1-2  alkyl, C 3-6  cycloalkyl, and C 1-3  haloalkyl; R 12  is selected from C 1-3  alkyl, halogen, \u2014OR a , \u2014NR a R b , CN, \u2014C(O)R a , \u2014C(O)OR a , \u2014C(O)NR a R b , \u2014OC(O)NR a R b , \u2014NR a C(O)R b , \u2014NR a C(O)NR b , \u2014NR a C(O)OR b , \u2014SR a , \u2014S(O) 1-2 R a , \u2014S(O) 2 NR a R b , \u2014NR a S(O) 2 R b , C 1-3  haloalkyl, C 3-6  cycloalkyl, 3 to 6 membered heterocyclyl wherein the 3 to 6 membered heterocyclyl has 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur, C 6-10  aryl, and 5 to 10 membered heteroaryl wherein the 5 to 10 membered heteroaryl has 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur, wherein the C 1-3  alkyl group is optionally substituted with 1 to 5 substituents independently selected from halogen, \u2014OR a , \u2014NR a R b , CN, \u2014C(O)R a , \u2014C(O)OR a , \u2014C(O)NR a R b , \u2014OC(O)NR a R b , \u2014NR a C(O)R b , \u2014NR a C(O)NR b , \u2014NR a C(O)OR b , \u2014SR a , \u2014S(O) 1-2 R a , \u2014S(O) 2 NR a R b , \u2014NR a S(O) 2 R b , C 1-3  haloalkyl, C 3-6  cycloalkyl, 3 to 6 membered heterocyclyl wherein the 3 to 6 membered heterocyclyl has 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur, C 6-10  aryl, and 5 to 10 membered heteroaryl wherein the 5 to 10 membered heteroaryl has 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur; R 13  is selected from C 1-6  alkyl, halogen, \u2014OR a , \u2014NR a R b , CN, \u2014C(O)R a , \u2014C(O)OR a , \u2014C(O)NR a R b , \u2014OC(O)NR a R b , \u2014NR a C(O)R b , \u2014NR a C(O)NR b , \u2014NR a C(O)OR b , \u2014SR a , \u2014S(O) 1-2 R a , \u2014S(O) 2 NR a R b , \u2014NR a S(O) 2 R b , C 1-6  haloalkyl, C 3-6  cycloalkyl, 3 to 6 membered heterocyclyl wherein the 3 to 6 membered heterocyclyl has 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur, C 6-10  aryl, and 5 to 10 membered heteroaryl wherein the 5 to 10 membered heteroaryl has 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur, wherein the C 1-6  alkyl is optionally substituted with 1 to 5 substituents independently selected from halogen, \u2014OR a , \u2014NR a R b , CN, \u2014C(O)R a , \u2014C(O)OR a , \u2014C(O)NR a R b , \u2014OC(O)NR a R b , \u2014NR a C(O)R b , \u2014NR a C(O)NR b , \u2014NR a C(O)OR b , \u2014SR a , \u2014S(O) 1-2 R a , \u2014S(O) 2 NR a R b , \u2014NR a S(O) 2 R b , C 1-6  haloalkyl, C 3-6  cycloalkyl, 3 to 6 membered heterocyclyl wherein the 3 to 6 membered heterocyclyl has 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur, C 6-10  aryl, and 5 to 10 membered heteroaryl wherein the 5 to 10 membered heteroaryl has 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur; each R 2 \u00b0 is independently selected from the group consisting of halogen, CN, \u2014NR a R b , and OR a ; and each R a  and R b  is independently selected from the group consisting of hydrogen and C 1-3  alkyl, wherein each C 1-3  alkyl is optionally substituted with 1 to 3 substituents independently selected from halogen, hydroxyl, amino, and C 1-6  haloalkyl.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 90.0
- Lexical Diversity: 1.25
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14998042', '15692093', '15885390', '14836774', '14998131']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7935044097590844
- 35 USC 102 Novelty (BERT): 0.5256801383896779
- Combined Prediction Score: 0.7667219826221439
- Mean Citation Score: 328.595098
- Max Citation Score: 344.2271
- Similarity Product: 285.72360867766145

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test