PATENT CLAIM ANALYSIS

Application Number: 15758274
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "233200"]

Abstract:
The present invention provides methods for inhibiting Fyn kinase, using 5-3-pyridin-2-amine, 6-3-imidazo[1,2-a] pyrazine, 6-3-imidazo[1,2-b] pyridazine, N-(5-imidazo [2,1-b][1,3,4] thiadiazol-2-yl)-amine, 4-3-1H-pyrazolo[3,4-b] pyridine, and N-(3-imidazo [1,2-b] pyridazin-6-yl) amine compounds and methods of treatment, prevention, inhibition or amelioration of diseases and conditions associated with Fyn kinase using such compounds.

Claim (Index 18):
A compound of formula (VI) selected from the group consisting of N-(2-methoxyethyl)-3-(3-thienyl)imidazo[1,2-b]pyridazin-6-amine, 3-(3,4-dimethoxyphenyl)-N-(2-methoxyethyl)imidazo[1,2-b]pyridazin-6-amine, 3-(4-fluorophenyl)-N-(2-methoxyethyl)imidazo[1,2-b]pyridazin-6-amine, 4-[6-(2-furylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzoic acid, N-(2-furylmethyl)-3-(4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-amine, [4-[6-(2-furylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, [3-[6-(2-furylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 1-[3-[6-(2-furylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, [4-[6-(2-thienylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol 3-(4-aminophenyl)-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, 3-(4-fluorophenyl)-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, 3-(3-methoxyphenyl)-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, 1-[3-[6-(2-thienylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 2-[[3-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, 2-[[3-(4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, 2-[[3-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, 2-[[3-(6-methoxy-3-pyridyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, 2-[[3-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, [3-[6-[(3-chlorophenyl)methylamino] imidazo[1,2-b]pyridazin-3-yl]phenyl] methanol, 3-(4-aminophenyl)-N-[(3-chlorophenyl)methyl] imidazo[1,2-b]pyridazin-6-amine, [4-[6-[(4-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, N-(1,3-benzodioxol-5-ylmethyl)-3-(4-pyridyl) imidazo[1,2-b]pyridazin-6-amine, 4-[6-(1,3-benzodioxol-5-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-(benzofuran-2-yl)-N-(4-pyridylmethyl)imidazo[1,2-b] pyridazin-6-amine, 3-(3-aminophenyl)-N-tetrahydropyran-4-yl-imidazo[1,2-b]pyridazin-6-amine, 3-(3,4-dimethoxyphenyl)-N-tetrahydropyran-4-yl-imidazo[1,2-b]pyridazin-6-amine, N-[3-[6-(tetrahydropyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-tetrahydropyran-4-yl-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-6-amine, 3-(1H-indol-5-yl)-N-tetrahydropyran-4-yl-imidazo[1,2-b]pyridazin-6-amine, 3-(3-methoxyphenyl)-N-tetrahydropyran-4-yl-imidazo[1,2-b]pyridazin-6-amine, 2-methoxy-4-[6-[(4-methoxyphenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenol, 3-[[3-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]propan-1-ol, 3-[[3-(1H-indol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]propan-1-ol, 3-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]propan-1-ol, 4-[6-(3-hydroxypropylamino)imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 3-[[3-(4-phenoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]propan-1-ol, (2S)-2-[[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino]-3-methyl-butan-1-ol, (2S)-2-[[3-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]-3-methyl-butan-1-ol, (2S)-2-[[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]-3-methyl-butan-1-ol, N-[3-[6-[[(1S)-1-(hydroxymethyl)-2-methyl-propyl]amino] imidazo[1,2-b]pyridazin-3-yl]phenyl] acetamide, 4-[6-[[(1S)-1-(hydroxymethyl)-2-methyl-propyl]amino]imidazo[1,2-b]pyridazin-3-yl]benzonitrile, (2S)-2-[[3-(4-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino]-3-methyl-butan-1-ol, 3-(1,3-benzodioxol-5-yl)-N-(2-pyridylmethyl)imidazo[1,2-b]pyridazin-6-amine, N-(cyclopropylmethyl)-3-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-6-amine, N-(2-furylmethyl)-3-phenyl-imidazo[1,2-b]pyridazin-6-amine, N-(2-furylmethyl)-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-6-amine, 3-(3-aminophenyl)-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, N-(2-thienylmethyl)-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-6-amine, 3-(4-methoxyphenyl)-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, 3-[6-(2-thienylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, 2-[[3-(2-thienyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, N-[(3-chlorophenyl)methyl]-3-(4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-amine, N-[(3-chlorophenyl)methyl]-3-(6-methoxy-3-pyridyl)imidazo[1,2-b]pyridazin-6-amine, 4-[6-[(3-chlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 3-(3-aminophenyl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine, 3-(1,3-benzodioxol-5-yl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine, N-propyl-3-(3-thienyl)imidazo[1,2-b]pyridazin-6-amine, 3-(3,4-dimethoxyphenyl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine, N-[3-[6-(propylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 4-[6-(propylamino)imidazo[1,2-b]pyridazin-3-yl]benzoic acid, 3-(4-methoxyphenyl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine, 3-[6-(propylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-(3-methoxyphenyl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine, 1-[3-[6-(propylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 4-[6-[(3,4-dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzoic acid, 3-phenyl-N-(4-pyridylmethyl)imidazo[1,2-b]pyridazin-6-amine, 3-(4-aminophenyl)-N-tetrahydropyran-4-yl-imidazo[1,2-b]pyridazin-6-amine, and 4-[6-[(2,4-dimethylphenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.6383
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13056331', '13057325', '12598882', '13049225', '14554714']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8308989611872515
- 35 USC 102 Novelty (BERT): 0.5336105831377584
- Combined Prediction Score: 0.8011701233823022
- Mean Citation Score: 353.30427799999984
- Max Citation Score: 374.5595
- Similarity Product: 293.069511658907

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test