PATENT CLAIM ANALYSIS

Application Number: 15910913
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["424", "499000"]

Abstract:
In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.

Claim (Index 21):
A method for the treatment of cancer in a patient in need of such treatment comprising administering to the patient a therapeutically effective amount of the stable, synthetic low density lipoprotein (LDL) nanoparticle comprising:\n a) a lipophilic anti-cancer agent of the formula 1a, 1b or formula 2a: wherein:\n for formula 1a or 1b R 1  is hydrogen, C 1 -C 4  alkyl or C 5 -C 22  alkyl; and R 2  is C 5 -C 22  alkyl; \n for formula 2a: R 2  is C 1 -C 22  alkyl; and X is hydrogen or is selected from the group consisting of Cl, Br and I; and \n R is a hydroxyl bearing cancer chemotherapeutic agent (HBCCA) selected from the group consisting of paclitaxel and docetaxel;\n b) phospholipids (PL) wherein the phospholipids is selected from the group consisting of phosphotidylcholine, phosphotidylethanolamine, symmetric or asymmetric 1,2-diacyl-sn-glycero-3-phosphorylcholines, 1,2-dimyristoyl-sn-glycero-3-phosphorylcholine, 1,2-dimyristoyl-sn-glycero-3-phosphorylethanolamine, egg phospholipids, egg phosphatidyl glycerol, dipalmitoylphosphatidyl glycerol, egg lecithin, soy lecithin, lecithin (NOS) and mixtures thereof; and \n c) triglycerides (TG); \n wherein the LDL nanoparticle has a mean particle size of 40-80 nm.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 90.0
- Lexical Diversity: 1.45614
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14485713', '15243659', '15675399', '13489247', '15131318']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7248033593546861
- 35 USC 102 Novelty (BERT): 0.6537721933391196
- Combined Prediction Score: 0.7177002427531295
- Mean Citation Score: 427.13168
- Max Citation Score: 614.1732
- Similarity Product: 606.4353103538989

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test