PATENT CLAIM ANALYSIS

Application Number: 16297115
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "210000"]

Abstract:
Indazole sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma RORγt are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of RORγt receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Claim (Index 1):
A compound of formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof and/or a solvate thereof: wherein:\n L represents a single bond or a methylene group CH 2 , \n X represents a cyclic radical chosen from the radicals X 1  and X 2  below: \n one or two of the elements Y 1 , Y 2 , Y 3 , Y 4  and Y 5  represent(s) a nitrogen atom and the other elements correspond to a group \u2014CR 2 , or each of the elements Y 1 -, Y 2 , Y 3 , Y 4  and Y 5  corresponds to a group \u2014CR 2 , each of the elements Q 1 , Q 2  and Q 3  corresponds to an identical or different \u2014CR 2a  group, R 1  represents a linear or branched C 3 -C 5  alkyl radical, optionally substituted with a hydroxyl group and/or a halogen atom, a C 3 -C 5  cycloalkyl radical, a linear or branched C 2 -C 5  alkenyl radical, a \u2014CH 2 \u2014(C 3 -C5)cycloalkyl radical, a C 4 -C 5  heterocycloalkyl radical, a \u2014CH 2 \u2014(C 4 -C 6 )heterocycloalkyl radical, R 2  represents a hydrogen atom or a halogen atom, a linear or branched C 1 -C 5  alkyl radical, a linear or branched C 2 -C 4  alkenyl radical, a C 1 -C 4  alkoxy radical, a cyano group \u2014CN, a radical \u2014C(\u2550O)R\u2032 2  with R\u2032 2  denoting a C 1 -C 3  alkoxy radical, a \u2014CF 3  radical; said alkyl, alkenyl and alkoxy radicals optionally being substituted with one or more halogen atoms, R 2a  represents a hydrogen atom or a halogen atom, a linear or branched C 1 -C 5  alkyl radical, a linear or branched C 2 -C 4  alkenyl radical, a C 1 -C 4  alkoxy radical, a-CN group, a hydroxyl group \u2014OH, a group \u2014CH(R 3a ) o H, a carboxylic group \u2014COOH, a carbamoyl group \u2014CONR 2c R 2d , an amido group \u2014NR 2c COR 2d , a group \u2014SO 2 R 2c , a group \u2014SOR 2c , a group \u2014S(\u2550O)(\u2550NH\u2014R 2c ), said alkyl, alkenyl and alkoxy radicals optionally being substituted with one or more halogen atoms, R 2c  and R 2d , which are identical or different, represent a hydrogen atom or a linear or branched C 1 -C 5  alkyl radical; R 3a  represents a hydrogen atom or a linear or branched C 1 -C 5  alkyl radical, R 3  represents a hydrogen atom, a halogen atom, a group (CHR 6 ) n \u2014(Z) o \u2014(CHR \u20326 ) p \u2014R 7  or a group CH\u2550R 7 , n, o and p, which are identical or different, represent zero or a natural integer ranging from 1 to 3, Z represents a divalent group selected from the group consisting of a methylene group \u2014CH 2 \u2014, an amino group \u2014NH\u2014 and an oxygen atom \u2014O\u2014, R 6  and R \u20326 , which are identical or different, represent a hydrogen atom, a methyl group \u2014CH 3 , a group \u2014OH, a hydroxymethyl group, or a carboxylic function-COOH, R 7  represents: a hydrogen or a halogen atom, a group COOR \u20327  with R \u20327  denoting (C 1 )alkyl(C 6 )heterocycle, a heterocycloalkyl radical, wherein the heterocycloalkyl radical is optionally substituted with one or more halogen atoms, one or more linear or branched C 1 -C 3  alkyl groups, one or more \u2014OH groups, one or more carbonyl functions, one or more linear or branched C 1 -C 4  hydroxyalkyl groups, one or more amino groups, one or more groups \u2014C(\u2550O)R 7a , one or more groups S(\u2550O) 2 R 7a ; R 7a  representing a linear or branched C 1 -C 3  alkyl radical, a linear or branched C 1 -C 3  alkoxy radical, or an amino radical N(R 8a )(R 8b ), a C 3 -C 6  cycloalkyl radical, wherein the cycloalkyl radical is optionally substituted with one or more methyl radicals, one or more halogen atoms, a cyano group \u2014CN or one or more groups \u2014COR 13 ; R 13  denoting a linear or branched C 1 -C 3  alkoxy radical, or a hydroxyl group, an aromatic radical, wherein the aromatic radical is optionally substituted with one or more halogen atoms, one or more linear or branched C 1 -C 3  alkyl groups optionally substituted with one or more halogen atoms, one or more C 1 -C 3  alkoxy groups, one or more amino groups \u2014NR 11 R 12 , one or more groups \u2014COR 11 , one or more groups \u2014COOR 11 , one or more amido groups-CONR 11 R 12 , one or more groups \u2014SOR 11 , one or more groups \u2014SO 2 R 11 , one or more groups \u2014NHCOR 11 , one or more groups \u2014NHCOOR 11 , one or more groups \u2014SO 2 NR 11 R 12  or one or more \u2014CN groups; R 11  and R 12 , which are identical or different, representing a hydrogen atom, a hydroxyl radical \u2014OH, a linear or branched C 1 -C 3  alkyl radical optionally substituted with one or more halogen atoms; a heteroaromatic radical, wherein the heteroaromatic radical is optionally substituted with one or more halogen atoms, one or more linear or branched C 1 -C 3  alkyl groups optionally substituted with one or more halogen atoms, one or more C 1 -C 3  alkoxy groups, one or more amino groups \u2014NR 11 R 12 , one or more groups \u2014COR 11 , one or more groups \u2014COOR 11 , one or more amido groups-CONR 11 R 12 , one or more groups \u2014SOR 11 , one or more groups \u2014SO 2 R 11 , one or more groups \u2014NHCOR 11 , one or more groups \u2014NHCOOR 11 , one or more groups \u2014SO 2 NR 11 R 12  or one or more \u2014CN groups; R 11  and R 12 , which are identical or different, representing a hydrogen atom, a hydroxyl radical \u2014OH, a linear or branched C 1 -C 3  alkyl radical optionally substituted with one or more halogen atoms; R 5  represents a hydrogen atom, a linear or branched C 1 -C 3  alkyl radical optionally substituted with one or more halogen atoms; an amino radical \u2014NH 2 , a C 4 -C 5  heterocyclic radical, an OCH 2 \u2014(C 4 -C 5 ) heterocyclic radical, a radical CH 2 R \u20327 a with R \u20327 a denoting a methoxy radical, a hydroxyl group \u2014OH, a \u2014CH 2 COOH group, a group \u2014CH(R 5b )OH, a carboxylic group \u2014COOH, a \u2014CN group, a thioxo function, R 5b  represents a hydrogen atom, a linear or branched C 1 -C 3  alkyl radical optionally substituted with one or more carboxylic functions; a cyclopropyl radical, and R 8a  and R 8b , which are identical or different, denote a hydrogen atom, a linear or branched C 1 -C 3  alkyl radical or a cyclopropyl radical.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 99.0
- Lexical Diversity: 1.44231
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15537678', '15537580', '15537667', '15537591', '11029064']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8498443586068778
- 35 USC 102 Novelty (BERT): 0.6092458810860829
- Combined Prediction Score: 0.8257845108547983
- Mean Citation Score: 456.877754
- Max Citation Score: 546.8221
- Similarity Product: 511.93900175986886

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test