PATENT CLAIM ANALYSIS

Application Number: 16142969
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "220000"]

Abstract:
The invention comprises methods of modulating the complement cascade in a mammal and for treating and/or preventing diseases and disorders associated with the complement pathway by administering a compound of Formula I or Formula II, such as, for example, 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one or a pharmaceutically acceptable salt thereof.

Claim (Index 21):
The method of  claim 19 , wherein the complement-associated disease or disorder involves the modulation of one or more genes selected from Mannose-Binding Lectin (protein C) 2, complement component 9, complement component 6, complement component 8, alpha polypeptide, complement component 4B, complement component 4A, coagulation factor IX, Coagulation factor VII, complement component 4 binding protein-beta, complement component 5, Protein C, coagulation factor XI, kallikrein B, plasma, tissue factor pathway inhibitor, complement component 8, gamma polypeptide, complement component 1-s subcomponent, complement component 8-beta polypeptide, coagulation factor XII, coagulation factor II, coagulation factor XIII B polypeptide, serpin peptidase inhibitor clade E, complement component 2, alpha-2-macroglobulin, complement factor H, complement factor I, complement factor B, complement component 1 R subcomponent, mannan-binding lectin serine peptidase 1, protein S, coagulation factor V, complement component 5a receptor 1, complement component 4 binding protein alpha, serpin peptidase inhibitor clade C member 1, complement component 3, mannan-binding lectin serine peptidase 2, coagulation factor X, coagulation factor VIII, serpin peptidase inhibitor clade D member 1, serpin peptidase inhibitor clade F member 2, plasminogen, bradykinin receptor B2, bradykinin receptor B1, serpin peptidase inhibitor clade A member 5, coagulation factor III, serpin peptidase inhibitor, clade G (C1 inhibitor) member 1, carboxypeptidase B2 (Plasma), fibrinogen beta chain, kininogen 1, complement component (3b/4b) receptor 1, plasminogen activator tissue, complement component (3d/epstein barr virus) receptor 2, thrombomodulin, CD55 molecule, decay accelerating factor for complement, complement component 1 Q subcomponent A chain, or complement component 7, plasminogen activator urokinase, complement factor D, complement component 1 Q subcomponent C chain, CD46 molecule complement regulatory protein, fibrinogen gamma chain, von willebrand factor, CD59 molecule complement regulatory, plasminogen activator urokinase receptor, serpin peptidase inhibitor clade A member 1, coagulation factor XIII A1 polypeptide, complement component 3a receptor 1, fibrinogen alpha chain, complement component 1 Q subcomponent, B chain, and/or coagulation factor II (thrombin) receptor.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 97.0
- Lexical Diversity: 1.31915
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15066513', '11670238', '14513281', '13257082', '13265060']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7193852294420331
- 35 USC 102 Novelty (BERT): 0.61448017021157
- Combined Prediction Score: 0.7088947235189867
- Mean Citation Score: 395.297994
- Max Citation Score: 685.7202
- Similarity Product: 447.4524398496508

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test