PATENT CLAIM ANALYSIS

Application Number: 15948450
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "044000"]

Abstract:
Provided herein are methods for the treatment of Alport Syndrome, using modified oligonucleotides targeted to miR-21. In certain embodiments, a modified oligonucleotide targeted to miR-21 improves kidney function and/or reduces fibrosis in subjects having Alport Syndrome. In certain embodiments, administration of a modified oligonucleotide targeted to miR-21 delays the onset of end-stage renal disease in a subject having Alport Syndrome. In certain embodiments, a modified oligonucleotide targeted to miR-21 delays the need for dialysis or kidney transplant in a subject having Alport Syndrome.

Claim (Index 1):
A method of treating Alport Syndrome comprising administering to a subject having or suspected of having Alport Syndrome a pharmaceutical composition comprising a therapeutically effective amount of a modified oligonucleotide consisting of 19 linked nucleosides and having the structure 5\u2032-A E C S ATC S AGTC S TGAU S AAGC S TA E -3\u2032 (SEQ ID NO: 3), where nucleosides not followed by a subscript are \u03b2-D-deoxyribonucleosides; nucleosides followed by a subscript \u201cE\u201d are 2\u2032-MOE nucleosides; nucleosides followed by a subscript \u201cS\u201d are S-cEt nucleosides, and each internucleoside linkage is a phosphorothioate internucleoside linkage, wherein the subject is male and wherein the Alport syndrome is the X-linked form of Alport syndrome.

Metadata:
- Claim Count in Document: 36.0
- Percentile: 91.0
- Lexical Diversity: 2.11628
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14048827', '14677387', '15606554', '15151290', '15441590']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8039106300988467
- 35 USC 102 Novelty (BERT): 0.655633566025898
- Combined Prediction Score: 0.7890829236915519
- Mean Citation Score: 559.7868599999998
- Max Citation Score: 620.1012
- Similarity Product: 614.188193338108

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test