PATENT CLAIM ANALYSIS

Application Number: 15898095
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "210020"]

Abstract:
Provided is a compound of Formula (I) wherein the variable groups are defined herein.

Claim (Index 1):
A compound of Formula (I) wherein: R 1  and R 2  are each independently selected from:\n a) C 1-10  alkyl optionally substituted with Z 1 ; \n b) C 3-10  cycloalkyl optionally substituted with Z 1 ; \n c) 5-10 membered heteroaryl optionally substituted with Z 1 ; \n d) C 6-10  aryl optionally substituted with Z 1 ; \n e) 4-7 membered monocyclic heterocyclyl optionally substituted with Z 1 ; \n f) 6-12 membered bicyclic heterocyclyl optionally substituted with Z 1 ; or \n g) \u2014N(R 12 )(R 12 ), \u2014S(O) 2 R 12 , \u2014S(O) 2 N(R 12 )(R 12 ), or \u2014H; \n R 3  and R 4  are each independently selected from:\n a) H, halo, \u2014NO 2 , \u2014CN, \u2014O\u2014R 12 , \u2014C(O)\u2014R 12 , \u2014C(O)\u2014N(R 12 )(R 12 ), \u2014N(R 12 )(R 12 ), \u2014N(R 12 )C(O)\u2014R 12 , \u2014N(R 12 )C(O)O\u2014R 12 , \u2014N(R 12 )S(O) 2 (R 12 ), \u2014N(R 12 )C(O)\u2014N(R 12 )(R 12 ), \u2014S(O) 2 R 12  or \u2014S(O) 2 N(R 12 )(R 12 ); \n b) C 1-9  alkyl optionally substituted with Z 1 ; \n c) C 2-9  alkynyl optionally substituted with Z 1 ; \n d) C 2-9  alkenyl optionally substituted with Z 1 ; \n e) 5-10 membered heteroaryl optionally substituted with Z 1 ; \n f) C 6-10  aryl optionally substituted with Z 1 ; \n g) 4-12 membered heterocyclyl optionally substituted with Z 1 ; or \n h) C 3-10  cycloalkyl optionally substituted with Z 1 ; \n R 5 , R 6  and R 7  are each independently selected from:\n a) H, halo, \u2014NO 2 , \u2014CN, \u2014O\u2014R 12 , \u2014C(O)\u2014R 12 , \u2014C(O)\u2014N(R 12 )(R 12 ), \u2014N(R 12 )(R 12 ), \u2014N(R 12 )C(O)\u2014R 12 , \u2014N(R 12 )C(O)O\u2014R 12 , or \u2014N(R 12 )S(O) 2 (R 12 ; \n b) C 1-5  alkyl optionally substituted with Z 1 ; or \n c) Cyclopropyl, oxetanyl or azetidinyl optionally substituted with Z 1 ; \n Z 1  is independently oxo, halo, \u2014NO 2 , \u2014N 3 , \u2014CN, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, \u2014O\u2014R 12 , \u2014C(O)\u2014R 12 , \u2014C(O)O\u2014R 12 , \u2014C(O)\u2014N(R 12 )(R 12 ), \u2014N(R 12 )(R 12 ), \u2014N(R 12 ) 2 (R 12 ) + , \u2014N(R 12 )C(O)\u2014R 12 , \u2014N(R 12 )C(O)O\u2014R 12 , \u2014N(R 12 )C(O)N(R 12 )(R 12 ), \u2014N(R 12 )S(O) 2 (R 12 ), \u2014NR 12 S(O) 2 N(R 12 )(R 12 ), \u2014NR 12 S(O) 2 O(R 12 ), \u2014OC(O)R 12 , \u2014OC(O)OR 12 , \u2014OC(O)\u2014N(R 12 )(R 12 ), \u2014Si(R 12 ) 3 , \u2014S\u2014R 12 , \u2014S(O)R 12 , \u2014S(O)(NH)R 12 , \u2014S(O) 2 R 12  or \u2014S(O) 2 N(R 12 )(R 12 ); wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z 1a ; each Z 1a  is independently oxo, halo, \u2014NO 2 , \u2014CN, \u2014N 3 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, \u2014O\u2014R 12 , \u2014C(O)R 12 , \u2014C(O)O\u2014R 12 , \u2014C(O)N(R 12 )(R 12 ), \u2014N(R 12 )(R 12 ), \u2014N(R 12 ) 2 (R 12 ) + , \u2014N(R 12 )\u2014C(O)R 12 , \u2014N(R 12 )C(O)O(R 12 ), \u2014N(R 12 )C(O)N(R 12 )(R 12 ), \u2014N(R 12 )S(O) 2 (R 12 ), \u2014N(R 12 )S(O) 2 \u2014N(R 12 )(R 12 ), \u2014N(R 12 )S(O) 2 O(R 12 ), \u2014OC(O)R 12 , \u2014OC(O)OR 12 , \u2014OC(O)\u2014N(R 12 )(R 12 ), \u2014Si(R 12 ) 3 , \u2014S\u2014R 12 , \u2014S(O)R 12 , \u2014S(O)(NH)R 12 , \u2014S(O) 2 R 12  or \u2014S(O) 2 N(R 12 )(R 12 ); wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z 1b ; each R 12  is independently H, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl; wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z 1a ; each Z 1b  is independently oxo, hydroxy, halo, \u2014NO 2 , \u2014N 3 , \u2014CN, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, \u2014O(C 1-9  alkyl), \u2014O(C 2-6  alkenyl), \u2014O(C 2-6  alkynyl), \u2014O(C 3-15  cycloalkyl), \u2014O(C 1-8  haloalkyl), \u2014O(aryl), \u2014O(heteroaryl), \u2014O(heterocyclyl), \u2014NH 2 , \u2014NH(C 1-9  alkyl), \u2014NH(C 2-6  alkenyl), \u2014NH(C 2-6  alkynyl), \u2014NH(C 3-15  cycloalkyl), \u2014NH(C 1-8  haloalkyl), \u2014NH(aryl), \u2014NH(heteroaryl), \u2014NH(heterocyclyl), \u2014N(C 1-9  alkyl) 2 , \u2014N(C 3-15  cycloalkyl) 2 , \u2014N(C 2-6  alkenyl) 2 , \u2014N(C 2-6  alkynyl) 2 , \u2014N(C 3-15  cycloalkyl) 2 , \u2014N(C 1-8  haloalkyl) 2 , \u2014N(aryl) 2 , \u2014N(heteroaryl) 2 , \u2014N(heterocyclyl) 2 , \u2014N(C 1-9  alkyl)(C 3-15  cycloalkyl), \u2014N(C 1-9  alkyl)(C 2-6  alkenyl), \u2014N(C 1-9  alkyl)(C 2-6  alkynyl), \u2014N(C 1-9  alkyl)(C 3-15  cycloalkyl), \u2014N(C 1-9  alkyl)(C 1-8  haloalkyl), \u2014N(C 1-9  alkyl)(aryl), \u2014N(C 1-9  alkyl)(heteroaryl), \u2014N(C 1-9  alkyl)(heterocyclyl), \u2014C(O)(C 1-9  alkyl), \u2014C(O)(C 2-6  alkenyl), \u2014C(O)(C 2-6  alkynyl), \u2014C(O)(C 3-15  cycloalkyl), \u2014C(O)(C 1-8  haloalkyl), \u2014C(O)(aryl), \u2014C(O)(heteroaryl), \u2014C(O)(heterocyclyl), \u2014C(O)O(C 1-9  alkyl), \u2014C(O)O(C 2-6  alkenyl), \u2014C(O)O(C 2-6  alkynyl), \u2014C(O)O(C 3-15  cycloalkyl), \u2014C(O)O(C 1-8  haloalkyl), \u2014C(O)O(aryl), \u2014C(O)O(heteroaryl), \u2014C(O)O(heterocyclyl), \u2014C(O)NH 2 , \u2014C(O)NH(C 1-9  alkyl), \u2014C(O)NH(C 2-6  alkenyl), \u2014C(O)NH(C 2-6  alkynyl), \u2014C(O)NH(C 3-15  cycloalkyl), \u2014C(O)NH(C 1-8  haloalkyl), \u2014C(O)NH(aryl), \u2014C(O)NH(heteroaryl), \u2014C(O)NH(heterocyclyl), \u2014C(O)N(C 1-9  alkyl) 2 , \u2014C(O)N(C 3-15  cycloalkyl) 2 , \u2014C(O)N(C 2-6  alkenyl) 2 , \u2014C(O)N(C 2-6  alkynyl) 2 , \u2014C(O)N(C 3-15  cycloalkyl) 2 , \u2014C(O)N(C 1-8  haloalkyl) 2 , \u2014C(O)N(aryl) 2 , \u2014C(O)N(heteroaryl) 2 , \u2014C(O)N(heterocyclyl) 2 , \u2014NHC(O)(C 1-9  alkyl), \u2014NHC(O)(C 2-6  alkenyl), \u2014NHC(O)(C 2-6  alkynyl), \u2014NHC(O)(C 3-15  cycloalkyl), \u2014NHC(O)(C 1-8  haloalkyl), \u2014NHC(O)(aryl), \u2014NHC(O)(heteroaryl), \u2014NHC(O)(heterocyclyl), \u2014NHC(O)O(C 1-9  alkyl), \u2014NHC(O)O(C 2-6  alkenyl), \u2014NHC(O)O(C 2-6  alkynyl), \u2014NHC(O)O(C 3-15  cycloalkyl), \u2014NHC(O)O(C 1-8  haloalkyl), \u2014NHC(O)O(aryl), \u2014NHC(O)O(heteroaryl), \u2014NHC(O)O(heterocyclyl), \u2014NHC(O)NH(C 1-9  alkyl), \u2014NHC(O)NH(C 2-6  alkenyl), \u2014NHC(O)NH(C 2-6  alkynyl), \u2014NHC(O)NH(C 3-15  cycloalkyl), \u2014NHC(O)NH(C 1-8  haloalkyl), \u2014NHC(O)NH(aryl), \u2014NHC(O)NH(heteroaryl), \u2014NHC(O)NH(heterocyclyl), \u2014SH, \u2014S(C 1-9  alkyl), \u2014S(C 2-6  alkenyl), \u2014S(C 2-6  alkynyl), \u2014S(C 3-15  cycloalkyl), \u2014S(C 1-8  haloalkyl), \u2014S(aryl), \u2014S(heteroaryl), \u2014S(heterocyclyl), \u2014NHS(O)(C 1-9  alkyl), \u2014N(C 1-9  alkyl)(S(O)(C 1-9  alkyl), \u2014S(O)N(C 1-9  alkyl) 2 , \u2014S(O)(C 1-9  alkyl), \u2014S(O)(NH)(C 1-9  alkyl), \u2014S(O)(C 2-6  alkenyl), \u2014S(O)(C 2-6  alkynyl), \u2014S(O)(C 3-15  cycloalkyl), \u2014S(O)(C 1-8  haloalkyl), \u2014S(O)(aryl), \u2014S(O)(heteroaryl), \u2014S(O)(heterocyclyl), \u2014S(O) 2 (C 1-9  alkyl), \u2014S(O) 2 (C 2-6  alkenyl), \u2014S(O) 2 (C 2-6  alkynyl), \u2014S(O) 2 (C 3-15  cycloalkyl), \u2014S(O) 2 (C 1-8  haloalkyl), \u2014S(O) 2 (aryl), \u2014S(O) 2 (heteroaryl), \u2014S(O) 2 (heterocyclyl), \u2014S(O) 2 NH(C 1-9  alkyl), or \u2014S(O) 2 N(C 1-9  alkyl) 2 ; wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one or more halo, C 1-9  alkyl, C 1-8  haloalkyl, \u2014OH, \u2014NH 2 , \u2014NH(C 1-9  alkyl), \u2014NH(C 3-15  cycloalkyl), \u2014NH(C 1-8  haloalkyl), \u2014NH(aryl), \u2014NH(heteroaryl), \u2014NH(heterocyclyl), \u2014N(C 1-9  alkyl) 2 , \u2014N(C 3-15  cycloalkyl) 2 , \u2014NHC(O)(C 3-15  cycloalkyl), \u2014NHC(O)(C 1-8  haloalkyl), \u2014NHC(O)(aryl), \u2014NHC(O)(heteroaryl), \u2014NHC(O)(heterocyclyl), \u2014NHC(O)O(C 1-9  alkyl), \u2014NHC(O)O(C 2-6  alkynyl), \u2014NHC(O)O(C 3-15  cycloalkyl), \u2014NHC(O)O(C 1-8  haloalkyl), \u2014NHC(O)O(aryl), \u2014NHC(O)O(heteroaryl), \u2014NHC(O)O(heterocyclyl), \u2014NHC(O)NH(C 1-9  alkyl), \u2014S(O)(NH)(C 1-9  alkyl), S(O) 2 (C 1-9  alkyl), \u2014S(O) 2 (C 3-15  cycloalkyl), \u2014S(O) 2 (C 1-8  haloalkyl), \u2014S(O) 2 (aryl), \u2014S(O) 2 (heteroaryl), \u2014S(O) 2 (heterocyclyl), \u2014S(O) 2 NH(C 1-9  alkyl), \u2014S(O) 2 N(C 1-9  alkyl) 2 , \u2014O(C 3-15  cycloalkyl), \u2014O(C 1-8  haloalkyl), \u2014O(aryl), \u2014O(heteroaryl), \u2014O(heterocyclyl), or \u2014O(C 1-9  alkyl); and with the proviso that when R 1  is C 3  alkyl, R 2  is C 5  alkyl substituted with F and hydroxyl, R 3 , R 5 , R 6 , R 7  are H, and R 4  is CN, then R 1  is substituted with Z 1 ; or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof.

Metadata:
- Claim Count in Document: 395.0
- Percentile: 88.0
- Lexical Diversity: 1.0
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15199779', '15697755', '15634314', '14132567', '14448160']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8244841825281862
- 35 USC 102 Novelty (BERT): 0.5528143954214264
- Combined Prediction Score: 0.7973172038175103
- Mean Citation Score: 406.291664
- Max Citation Score: 435.49445
- Similarity Product: 311.29330188248747

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test