PATENT CLAIM ANALYSIS

Application Number: 15996723
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["546", "256000"]

Abstract:
Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

Claim (Index 20):
A method for treating a cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of (a) a compound of formula (I) or a pharmaceutically acceptable salt thereof or (b) a composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein: X is a bond, \u2014S\u2014, \u2014S(O)\u2014, \u2014SO 2 \u2014, \u2014CH\u2550CH\u2014, or \u2014C(O)\u2014; each W, Y and Z is independently \u2014S\u2014, \u2014CH\u2550, \u2014O\u2014, \u2014N\u2550, or \u2014NH\u2014, provided that (1) at least one of W, Y and Z is not \u2014CH\u2550 and (2) when one of W is \u2014S\u2014 and the Y in the same ring is N, then the Z in the same ring is not \u2014CH\u2550; each R 1  and R 2  is independently C 1-6  alkylene-R 4 , N(R 3 )\u2014C(O)\u2014R 4 , \u2014C(O)\u2014N(R 3 )\u2014R 4 , N(R 3 )\u2014C(O)\u2014O\u2014R 4 , \u2014N(R 3 )\u2014C(O)\u2014N(R 3 )\u2014R 4 , \u2014O\u2014C(O)\u2014N(R 3 )\u2014R 4 , \u2014N(R 3 )\u2014C(O)\u2014C 1-6  alkylene-C(O)\u2014R 4 , \u2014N(R 3 )\u2014C(O)\u2014C 1-6  alkylene-N(R 3 )\u2014C(O)\u2014R 4  or \u2014N(R 3a )\u2014C(O)\u2014CH 2 \u2014N(R 3 )\u2014C(O)\u2014R 4 ; each R 3  is independently hydrogen, C 1-6  alkyl or aryl; each R 4  is independently C 1-6  alkyl, C 1-6  alkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl, heterocyclyl, cycloalkyl or cycloalkylalkyl, each of which is substituted with 0-3 occurrences of R 5 , or two adjacent R 5  moieties, taken together with the atoms to which they are attached form a heterocyclyl, heteroaryl, cycloalkyl or aryl; each R 5  is independently oxo (\u2550O), C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, cyano, halo, \u2014OH, \u2014SH, \u2014OCF 3 , \u2014SO 2 \u2014C 1-6  alkyl, \u2014NO 2 , \u2014N(R 7 )\u2014C(O)\u2014C 1-6  alkyl, \u2014N(R 6 ) 2 , \u2014O\u2014C(O)\u2014C 1-6  alkyl, C 3-7  cycloalkyl, (C 3-7  cycloalkyl)alkyl, aryl, aryloxy, \u2014C(O)-aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl or heterocyclyl, wherein each aryl, heteroaryl or heterocyclyl is further substituted with 0-3 occurrences of R 7 ; each R 6  is independently hydrogen, OH or C 1-6  alkyl; each R 7  is independently hydrogen, C 1-6  alkyl, \u2014OH, \u2014SH, cyano, halo, \u2014CF 3 , \u2014OCF 3 , \u2014SO 2 \u2014C 1-6  alkyl, \u2014NO 2 , \u2014N(R 7 )\u2014C(O)\u2014C 1-6  alkyl, \u2014N(R 6 ) 2  or C 1-6  alkoxy; m is 1, 2 or 3; n is 1, 2 or 3; provided that when X is bond, the sum of m and n is from 3 to 6 and when X is \u2014S\u2014, \u2014S(O)\u2014, \u2014SO 2 \u2014, \u2014CH\u2550CH\u2014, or \u2014C(O)\u2014, the sum of m and n is from 2 to 4; o is 1, 2 or 3; and p is 1, 2 or 3; with the proviso that: (1) when X is \u2014S\u2014, m and n are both 2, each R 6  is H, then (i) R 1  and R 2  are not both \u2014NHC(O)\u2014R 4 , wherein R 4  is C 1-6  alkyl, monocyclic aryl, monocyclic heteroaryl, monocyclic aralkyl, monocyclic heteroaralkyl and each member of R 4  is substituted with 0-3 occurrences of R 5 ; and (ii) R 1  and R 2  are not both \u2014NHC(O)O-methyl, \u2014NHC(O)O-ethyl, \u2014NHC(O)-6-pyrimidine-2,4(1H,3H)-dionyl, or \u2014NHC(O)NH-phenyl wherein said phenyl of the \u2014NHC(O)NH\u2014 phenyl moiety is optionally substituted with 1 or 2 groups selected from methyl, nitro, and halo; (2) when X is \u2014S\u2014, m and n are both 1, each R 6  is H, then (i) R 1  and R 2  are not both \u2014NH-phenyl or \u2014NH-4-methoxy-phenyl; (3) when X is a bond, the sum of m and n is 3, each R 6  is H, then R 1  and R 2  are not both NHC(O)-phenyl; (4) when X is a bond, m and n are both 2, each R 6  is H, then R 1  and R 2  are not both \u2014NHC(O)-furanyl, \u2014NHC(O)-phenyl, \u2014NHC(O)-o-methoxy-phenyl, \u2014NHC(O)\u2014C 1-6  alkyl, \u2014NH\u2014 benzyl, or \u2014NH-phenyl wherein said phenyl of the \u2014NH-phenyl moiety is substituted with 0-3 occurrences of R 5 ; (5) when X is a bond, the sum of m and n is 5, each R 6  is H, then R 1  and R 2  are not both \u2014NHC(O)\u2014C 1-6  alkyl, \u2014NHC(O)-cyclohexyl, or \u2014NH-phenyl wherein said phenyl of the \u2014NH-phenyl moiety is optionally substituted with methyl; and (6) when X is a bond, m and n are both 3, each R 6  is H, then R 1  and R 2  are not both NH-phenyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 94.0
- Lexical Diversity: 1.5
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14085947', '14646239', '14086003', '15127742', '14646634']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7866976357519668
- 35 USC 102 Novelty (BERT): 0.5671052105925244
- Combined Prediction Score: 0.7647383932360227
- Mean Citation Score: 416.439832
- Max Citation Score: 501.6011
- Similarity Product: 332.7157954990506

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test