PATENT CLAIM ANALYSIS

Application Number: 15977774
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["435", "366000"]

Abstract:
The present invention is directed to methods for the growth, expansion, and differentiation of pluripotent stem cells on planar substrates lacking an adlayer and a feeder cell layer.

Claim (Index 1):
A method of differentiating human pluripotent stem cells into definitive endoderm cells on a porous planar substrate comprising the steps of:\n (a) adding a cell suspension of human pluripotent stem cells to the porous planar substrate; (b) allowing the suspension of human pluripotent stem cells to attach; and (c) differentiating the attached human pluripotent stem cells into human definitive endoderm cells by treating human pluripotent stem cells with activin A under serum free conditions,\n wherein the porous planar substrate has the following features:\n contains from about 3.1% N to about 12% N; \n contains from at least about 12% O to at least about 55% O; \n lacks an adlayer and a feeder cell; \n is hydrophilic; and \n comprises polycarbonate or mixed cellulose esters.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 93.0
- Lexical Diversity: 1.06897
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12621702', '12388930', '14631019', '12277904', '14719124']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5754881701617527
- 35 USC 102 Novelty (BERT): 0.6216882086988167
- Combined Prediction Score: 0.5801081740154591
- Mean Citation Score: 500.98923199999984
- Max Citation Score: 648.96246
- Similarity Product: 493.9383600873327

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test