PATENT CLAIM ANALYSIS

Application Number: 16299928
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-06
Patent Classification: ["514", "013700"]

Abstract:
Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is often complicated by pathogenic antibody responses, including antibodies that neutralize the therapeutic protein or that predispose to potentially life-threatening anaphylactic reactions by formation of IgE. Using murine and canine hemophilia as a model, we have developed a prophylactic protocol against such responses that is non-invasive and does not include immune suppression or genetic manipulation of the patient's cells. Oral delivery of a coagulation factor expressed in chloroplasts, bioencapsulated in plant cells, effectively blocked formation of inhibitory antibodies in protein replacement therapy. Inhibitor titers were mostly undetectable and up to 100-fold lower in treated subjects when compared to controls. Moreover, this treatment eliminated fatal anaphylactic reactions that occurred after four to six exposures to intravenous coagulation factor protein. Finally, the method can effectively be used to reverse or reduce undesirable pre-existing inhibitor titers.

Claim (Index 24):
An isolated recombinantly produced nucleic acid encoding a fragment of Factor VIII selected from the group consisting of a heavy chain (HC) fragment encoding by SEQ ID NO: 10, and/or a light chain (LC) fragment encoded by SEQ ID NO: 14, each fused to cholera non-toxic B subunit (CTB) of SEQ ID NO: 6.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 99.0
- Lexical Diversity: 1.47664
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15037045', '13508754', '15030377', '14353980', '14438571']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7833886587720844
- 35 USC 102 Novelty (BERT): 0.6400296835653618
- Combined Prediction Score: 0.7690527612514122
- Mean Citation Score: 404.93867200000005
- Max Citation Score: 673.7659
- Similarity Product: 533.3575768590213

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test