PATENT CLAIM ANALYSIS

Application Number: 15884691
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["506", "009000"]

Abstract:
A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents and methods of diagnosing ovarian cancer include use of CLIC4 ligands and/or multiple tropomyosin ligands with an additional ovarian cancer biomarker. For example, CLIC4 combined with one or more of CLIC1 and/or one or multiple members of the tropomyosin family, e.g., TPM1, TPM2, TPM3 or TPM4, and further optionally including CTSD-30 kDa and/or PRDX-6, among other ovarian cancer biomarkers can form a characteristic diagnostic pattern or profile of expression that is diagnostic of the disease. Still other embodiments are described.

Claim (Index 12):
A method for diagnosing or detecting or monitoring the progress or treatment of ovarian cancer in a subject comprising:\n contacting a sample obtained from a test subject with a diagnostic reagent or device consisting of\n (a) a ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form, posttranslational modification, or unique peptide fragment or unique nucleic acid fragment thereof; \n (b) a ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 1 (CLIC1) or an isoform, pro-form, modified molecular form, posttranslational modification, or unique peptide fragment or unique nucleic acid fragment thereof; and \n (c) a ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker cathepsin D-30 (CTSD-30) or an isoform, pro-form, modified molecular form, posttranslational modification, or unique peptide fragment or unique nucleic acid fragment thereof; and \n one or more additional ligands, each additional ligand capable of specifically complexing with, binding to, or quantitatively detecting, or identifying an additional biomarker that indicates the presence of ovarian cancer in a human subject, wherein said additional biomarker is selected from:\n i. tropomyosin 1 (TPM1); \n ii. tropomyosin 2 (TPM2); \n iii. tropomyosin 3 (TPM3); \n iv. tropomyosin 4 (TPM4); \n v. proteasome subunit alpha type-7 (PSMA7) \n vi. CA125; and \n vii. HE4, \n (ii) detecting or measuring in the sample or from a protein level profile generated from the sample, the protein levels of the selected biomarkers; (iii) comparing the protein level of the selected biomarkers in the subject's sample with the level of the same biomarkers in a reference standard; wherein a significant change in protein level of the subject's sample from that in the reference standard indicates a diagnosis, risk, or the status of progression or remission of ovarian cancer in the subject.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 86.0
- Lexical Diversity: 1.87619
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14045452', '11950416', '13397442', '15386714', '13372137']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5385932881013706
- 35 USC 102 Novelty (BERT): 0.733283012772795
- Combined Prediction Score: 0.558062260568513
- Mean Citation Score: 442.0482
- Max Citation Score: 979.633
- Similarity Product: 784.1288098353743

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test