PATENT CLAIM ANALYSIS

Application Number: 16295536
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-08
Patent Classification: ["424", "133100"]

Abstract:
Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.

Claim (Index 19):
The method of  claim 1 , further comprising:\n (i) measuring the mRNA expression level of at least one, at least two, or at least three Low Expression Predictive Genes (\u201cLEPG\u201d) selected from the group consisting of SLC8A3, VNN2, BEST2, CCL2, CCL3, CCL3L1/3, CPA3, FGF7, HAMP, IL1A, IL18RAP, INHBA, LIF, LMO4, LRRC4, MLK7.AS1, MT1M, MUCL1, MX1, PMCH, REM2, SSTR2, TM4SF4, TMEM154, UROS, and VNN3 in the biological sample; (ii) comparing the mRNA expression level of each of the LEPG measured in (i) to a reference level for each of the respective LEPG (\u201crespective LEPG reference level\u201d); and (iii) predicting that the patient will likely respond to the therapy when the mRNA expression level of TNFSF15 measured in (a) is below the reference level for TNFSF15, and the mRNA expression level of each of the LEPG measured in (i) is below the respective LEPG reference level.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 99.0
- Lexical Diversity: 1.84615
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15271687', '14675081', '13348709', '12390730', '11219121']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6816470800797682
- 35 USC 102 Novelty (BERT): 0.7807708231856388
- Combined Prediction Score: 0.6915594543903553
- Mean Citation Score: 470.705118
- Max Citation Score: 938.87976
- Similarity Product: 922.5867655839444

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test