PATENT CLAIM ANALYSIS

Application Number: 15910307
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "259300"]

Abstract:
The invention provides novel compounds having the general formula (I) wherein R A , R B , R C , R C1  and W are as defined herein, compositions including the compounds and methods of using the compounds.

Claim (Index 4):
A compound according to any one of  claims 1  to  3 , wherein\n R A  is selected from the group consisting of\n i) C 1 -C 6 -alkyl, \n ii) cyano-C 1 -C 6 -alkyl, \n iii) C 3 -C 8 -cycloalkyl, \n iv) aryl substituted with R G  and R G1 , \n v) heterocycloalkyl substituted with R G  and R G1 , and \n vi) heteroaryl substituted with R G  and R G1 ; \n \n R B  is selected from the group consisting of\n i) C 1 -C 6 -alkyl, \n ii) C 1 -C 6 -alkylsulfonyl, \n iii) C 1 -C 6 -alkylsulfonylamino, \n iv) aminocarbonyl, \n v) cyano, \n vi) halogen, \n vii) heterocycloalkyl, and \n viii) heteroaryl substituted with one H, C 1 -C 6 -alkyl or trialkylsilyl-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl; \n \n R C1  is H and R C  is selected from the group consisting of\n i) H, \n ii) C 1 -C 6 -alkyl, and \n iii) halogen; \n \n or R B  and R C  together with the carbon atoms to which they are attached form a ring system selected from the group consisting of\n i) heterocycloalkyl substituted with one to two substituent independently selected from H and C 1 -C 6 -alkyl, and \n ii) heteroaryl substituted with one to two substituent independently selected from H and C 1 -C 6 -alkyl; \n \n W is selected from the ring systems A, B, C, D and E; \n A 1 , A 3  and A 4  are \u2014CH\u2014 and A 2  is \u2014CR D2 \u2014, A 1  is \u2014N\u2014, A 2  is \u2014CR D2 \u2014, A 3  is \u2014CH\u2014 or \u2014N\u2014 and A 4  is \u2014CH\u2014, A 1 , A 3  and A 4  are \u2014CH\u2014 and A 2  is \u2014N\u2014, or A 1  and A 3  are \u2014CH\u2014, A 2  is \u2014CR D2 \u2014 and A 4  is \u2014N\u2014; one of A 5  and A 6  is \u2014NR D3 \u2014 and the other one is \u2014CR L R M \u2014; R D , is C 1 -C 6 -alkyl; R D2  is selected from the group consisting of\n i) H, \n ii) halogen, \n iii) hydroxy-C 1 -C 6 -alkoxy, \n iv) hydroxy-C 1 -C 6 -alkyl(C 1 -C 6 -alkyl)amino, \n v) hydroxy-C 1 -C 6 -alkylamino, \n vi) dihydroxy-C 1 -C 6 -alkoxy, \n vii) dihydroxy-C 1 -C 6 -alkyl(C 1 -C 6 -alkyl)amino, and \n viii) heterocycloalkyl; \n R D3  is selected from the group consisting of\n i) H, \n ii) C 1 -C 6 -alkoxy-C 1 -C 6 -alkylcarbonyl, \n iii) C 1 -C 6 -alkoxycarbonyl, and \n iv) C 1 -C 6 -alkylcarbonyl; \n R D4  is selected from the group consisting of\n i) H, \n ii) C 1 -C 6 -alkoxycarbonyl, \n iii) heterocycloalkylcarbonyl, and \n iv) aminocarbonyl substituted on the nitrogen atom with one to two independently selected C 1 -C 6 -alkyl; \n R G  is selected from the group consisting of\n i) H, \n ii) C 1 -C 6 -alkoxy, \n iii) C 1 -C 6 -alkoxy-C 1 -C 6 -alkylcarbonylamino-C 1 -C 6 -alkyl, \n iv) C 1 -C 6 -alkoxy-C 1 -C 6 -alkylcarbonyl(C 1 -C 6 -alkyl)amino-C 1 -C 6 -alkyl, \n v) C 1 -C 6 -alkoxycarbonyl, \n vi) C 1 -C 6 -alkyl, \n vii) C 1 -C 6 -alkylsulfonyl, \n viii) carboxy, \n ix) cyano, \n x) C 3 -C 8 -cycloalkoxy, \n xi) C 3 -C 8 -cycloalkylcarbonylamino-C 1 -C 6 -alkyl, \n xii) C 3 -C 8 -cycloalkylcarbonyl(C 1 -C 6 -alkyl)amino-C 1 -C 6 -alkyl, \n xiii) halo-C 1 -C 6 -alkyl, \n xiv) halogen, \n xv) hydroxy, \n xvi) aminocarbonyl substituted on the nitrogen atom with R N  and R O , \n xvii) aminocarbonyl-C 1 -C 6 -alkoxy substituted on the nitrogen atom with R N  and R O , \n xviii) heteroaryl substituted with one H or C 1 -C 6 -alkyl, \n xix) heterocycloalkyl-C 1 -C 6 -alkoxy substituted with one H or C 1 -C 6 -alkyl, and \n xx) heterocycloalkyl-C 1 -C 6 -alkyl substituted with one H or C 1 -C 6 -alkyl; \n R G1  and R G2  are independently selected from the group consisting of\n i) H, \n ii) halogen, \n iii) C 1 -C 6 -alkyl, and \n iv) halo-C 1 -C 6 -alkoxy; \n R L  and R M  are H; R N  is selected from the group consisting of\n xii) H, \n xiii) C 1 -C 6 -alkoxy, \n xiv) C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, \n xv) C 1 -C 6 -alkoxycarbonyl-C 1 -C 6 -alkyl, \n xvi) C 1 -C 6 -alkyl, \n xvii) carboxy-C 1 -C 6 -alkyl, \n xviii) C 3 -C 8 -cycloalkyl, \n xix) C 3 -C 8 -cycloalkyl-C 1 -C 6 -alkyl, \n xx) hydroxy-C 1 -C 6 -alkyl, \n xxi) phenyl, and \n xxii) heteroaryl-C 1 -C 6 -alkyl; \n R O  is selected from the group consisting of\n i) H, and \n ii) C 1 -C 6 -alkyl; \n or R N  and R O  together with the nitrogen atom to which they are attached form a heterocycloalkyl; or pharmaceutically acceptable salts.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 90.0
- Lexical Diversity: 1.35484
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12462417', '14844991', '15332398', '12466785', '14376307']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8091664087983156
- 35 USC 102 Novelty (BERT): 0.5386019237865759
- Combined Prediction Score: 0.7821099602971416
- Mean Citation Score: 361.796304
- Max Citation Score: 369.039
- Similarity Product: 275.26818266057967

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test