PATENT CLAIM ANALYSIS

Application Number: 15769414
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "220000"]

Abstract:
The present invention is directed to tricyclic compounds of formula (I), (Ia) or (Ib) which are inhibitors of one or more mutant IDH enzymes. The present invention is also directed to uses of these tricyclic compounds in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

Claim (Index 14):
The compound of  claim 1  selected from the group consisting of:\n (8-Chloro-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-Chloro-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(trans-4-isopropoxycyclohexyl)methanone, \n (8-Bromo-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(trans-4-isopropoxycyclohexyl)methanone, \n (8-Chloro-3,9-difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(trans-4-isopropoxycyclohexyl)methanone, \n (8-Chloro-3,9-difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (3-Fluoro-8-((3R,3aR,6R,6aR)-hexahydro-3,6-epiminofuro[3,2-b]furan-7-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-(2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-(2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (3-Fluoro-8-((1R,3r,5S)-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-((2S,5S)-2,5-Dimethylmorpholino)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (3-Fluoro-8-(6-oxa-2-azaspiro[3.5]nonan-2-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n [3-Fluoro-8-(2-oxa-5-azabicyclo[2.2.2]oct-5-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl][trans-4-(propan-2-yloxy)cyclohexyl]methanone, \n [3-Fluoro-8-(2-oxa-5-azabicyclo[2.2.2]oct-5-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl][trans-4-(propan-2-yloxy)cyclohexyl]methanone, \n (8-41R,5S)-3,9-Dioxa-7-azabicyclo[3.3.1]nonan-7-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n [3-Fluoro-8-(6-oxa-2-azaspiro[3.5]non-2-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl][trans-4-(propan-2-yloxy)cyclohexyl]methanone, \n (3-Fluoro-8-((3R,3aR,6R,6aR)-hexahydro-3,6-epiminofuro[3,2-b]furan-7-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(trans-4-isopropoxycyclohexyl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(trans-4-isopropoxycyclohexyl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(cis-4-isopropoxycyclohexyl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-3,9-difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (3,9-Difluoro-8-(6-oxa-2-azaspiro[3.5]nonan-2-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (3,9-Difluoro-8-((3R,3aR,6R,6aR)-hexahydro-3,6-epiminofuro[3,2-b]furan-7-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-((2S,5S)-2,5-Dimethylmorpholino)-3,9-difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n {3,9-Difluoro-8-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl}[trans-4-(propan-2-yloxy)cyclohexyl]methanone, \n [3,9-Difluoro-8-(6-oxa-2-azaspiro[3.5]non-2-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl][trans-4-(propan-2-yloxy)cyclohexyl]methanone, \n [3,9-Difluoro-8-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl][trans-4-(propan-2-yloxy)cyclohexyl]methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-9-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (9-Fluoro-8-((3R,3aR,6R,6aR)-hexahydro-3,6-epiminofuro[3,2-b]furan-7-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-(2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3,9-difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (3,9-Difluoro-8-41R,3r,5S)-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-41R,4R)-2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3,9-difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3,9-difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-((S)-1,4-Dioxan-2-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-((R)-1,4-dioxan-2-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-(1,4-Dioxan-2-yl)-3,9-difluoro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-6(11H)-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-(1,4-Dioxan-2-yl)-9-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-(1,4-Dioxan-2-yl)-9-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (3-Fluoro-8-((1R,3S,5S)-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (3-Fluoro-8-(6-oxa-2-azaspiro[3.5]nonan-2-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-41R,5S)-3,9-Dioxa-7-azabicyclo[3.3.1]nonan-7-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-(((3-(Chloromethyl)tetrahydro-2H-pyran-3-yl)methyl)amino)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-(2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(ethylsulfonyl)piperidin-4-yl)methanone, \n (8-(2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3,9-difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (3,9-Difluoro-8-(6-oxa-2-azaspiro[3.5]nonan-2-yl)-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-6(11H)-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-3,9-difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (3,9-Difluoro-8-((1R,3S,5S)-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-41R,4R)-2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (3,9-Difluoro-8-(1-methyl-1H-pyrazol-5-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (3,9-Difluoro-8-(1H-pyrazol-5-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (9-Fluoro-8-(1-methyl-1H-pyrazol-4-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (9-Fluoro-8-(1-methyl-1H-pyrazol-5-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (S)-(8-(1,4-Dioxan-2-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (R)-(8-(1,4-Dioxan-2-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (R)-(8-(1,4-Dioxan-2-yl)-9-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (S)-(8-(1,4-Dioxan-2-yl)-9-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (Trans-4-isopropoxycyclohexyl){9-methyl-8-[(1S,4S)-2-oxa-5-azabicyclo[2.2.2]oct-5-yl]-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl}methanone, \n (Trans-4-isopropoxycyclohexyl){7-methyl-8-[(1S,4S)-2-oxa-5-azabicyclo[2.2.2]oct-5-yl]-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl}methanone, \n (Trans-4-isopropoxycyclohexyl){9-methyl-8-[(1R,4R)-2-oxa-5-azabicyclo[2.2.2]oct-5-yl]-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl}methanone, \n (Trans-4-isopropoxycyclohexyl){7-methyl-8-[(1R,4R)-2-oxa-5-azabicyclo[2.2.2]oct-5-yl]-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl}methanone, \n [9-Fluoro-8-(2-oxa-5-azabicyclo[2.2.2]oct-5-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl](trans-4-isopropoxycyclohexyl)methanone, \n [7-Fluoro-8-(2-oxa-5-azabicyclo[2.2.2]oct-5-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl](trans-4-isopropoxycyclohexyl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-9-fluoro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-6(11H)-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone, \n (8-Chloro-5-methyl-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(trans-4-isopropoxycyclohexyl)methanone, \n (Trans-4-isopropoxycyclohexyl)(5-methyl-8-morpholino-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)methanone, \n (8-Methoxy-5-methyl-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (Trans-4-isopropoxycyclohexyl)(8-methoxy-5-methyl-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3-methyl-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(trans-4-isopropoxycyclohexyl)methanone, \n (8-((1S,4S)-2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3-(methylsulfonyl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(trans-4-isopropoxycyclohexyl)methanone, \n (8-((1S,45)-2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3-chloro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(trans-4-isopropoxycyclohexyl)methanone, \n (3,9-Difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n (8-(2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-3,9-difluoro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-6(11H)-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, and \n (9-Fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone, \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 2.46154
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15532549', '15532552', '15532548', '12890812', '13477587']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8097298718953719
- 35 USC 102 Novelty (BERT): 0.6348448875043009
- Combined Prediction Score: 0.7922413734562649
- Mean Citation Score: 427.697942
- Max Citation Score: 615.6298
- Similarity Product: 537.7108656196593

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test