PATENT CLAIM ANALYSIS

Application Number: 15895674
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "055000"]

Abstract:
The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.

Claim (Index 19):
A method of determining the biocompatibility of the composition of  claim 1  by measuring elicitation of an elevated cytokine IL-1\u03b2 response using a modified acute toxicity test.

Metadata:
- Claim Count in Document: 31.0
- Percentile: 88.0
- Lexical Diversity: 1.58763
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14211632', '15371010', '14638770', '13830268', '13908299']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8288726388560315
- 35 USC 102 Novelty (BERT): 0.5827928059394414
- Combined Prediction Score: 0.8042646555643725
- Mean Citation Score: 437.023826
- Max Citation Score: 572.2557
- Similarity Product: 379.9362595658183

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test