PATENT CLAIM ANALYSIS

Application Number: 15987321
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "093700"]

Abstract:
Methods and compositions for producing mature myotubes are provided herein. In some instances, the method involves contacting a myoblast in an in vitro culture with a compound, wherein the contacting the myoblast in the in vitro culture with the compound results in generation of mature myotubes or myotube-like cells. In some cases, methods of treatment are provided involving treating a subject with a compound such as a Chk1 inhibitor in order to treat muscle deficiency. The compound may be administered as a stand-alone therapy or in combination with a cell therapy, such as introduction of muscle precursor cells such as satellite cells or myoblasts. Methods for identifying compounds that induce formation of mature myotubes or myotube-like cells from myoblasts are also provided herein, as well as methods of using the identified compounds to treat subjects.

Claim (Index 24):
The method of  claim 20 , wherein the mature myotubes are generated less than 30 days from the contacting the pluripotent stem cells with the one or more compounds to generate the satellite cells and wherein the mature myotubes are generated at a rate of at least 50 mature myotubes per pluripotent stem cell.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 93.0
- Lexical Diversity: 2.01389
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13653021', '14401612', '13523337', '12340933', '14277969']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7108488562252168
- 35 USC 102 Novelty (BERT): 0.5318174728752414
- Combined Prediction Score: 0.6929457178902192
- Mean Citation Score: 299.565084
- Max Citation Score: 314.81412
- Similarity Product: 189.75507504246

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test