PATENT CLAIM ANALYSIS

Application Number: 15997267
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["564", "457000"]

Abstract:
The present invention is directed to processes for the preparation of esketamine. The present invention is further directed to processes for the resolution of S-ketamine from a racemic or enantiomerically enriched mixture of ketamine. The present invention is further directed to an (S)-CSA salt of S-ketamine, more particularly a monohydrate form of the (S)-CSA salt of S-ketamine; and to an (R)-CSA salt of R-ketamine.

Claim (Index 27):
A process for the preparation of S-ketamine hydrochloride comprising the following steps:\n Step 1: reacting ketamine with (R)-camphorsulfonic acid, wherein the (R)-camphorsulfonic acid is present in an amount in the range of from about 0.5 to about 2.0 molar equivalents (relative to the molar amount of ketamine); in the presence of water, wherein the water is present in an amount in the range of from about 3.5% to about 15%; in an organic solvent; at a temperature in the range of from about 20\u00b0 C. to about solvent reflux temperature; to yield a product mixture comprising (R)-camphorsulfonic acid salt of S-ketamine as a solid and S-ketamine in solution; wherein the (R)-camphorsulfonic acid salt of R-ketamine is present in an enantiomeric excess in the range of from about 50% to about 100%; Step 2: filtering the product mixture to yield the (R)-camphorsulfonic acid salt of R-ketamine as a solid and a filtrate comprising S-ketamine; and Step 3: reacting the S-ketamine with HCl; to yield the corresponding S-ketamine hydrochloride salt.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 94.0
- Lexical Diversity: 2.0
- Patent Class: 564.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15182698', '12417671', '14689712', '13630309', '14261713']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6563233569274988
- 35 USC 102 Novelty (BERT): 0.5282257258838652
- Combined Prediction Score: 0.6435135938231354
- Mean Citation Score: 221.77484600000005
- Max Citation Score: 268.33234
- Similarity Product: 206.0189420824576

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test