PATENT CLAIM ANALYSIS

Application Number: 15533266
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["514", "281000"]

Abstract:
The application provides compounds of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , dash line a, dash line b, W, Z, X, and m are defined as set forth in the specification. The invention is also directed to use of the compounds of Formula I and the pharmaceutically acceptable salts and solvates thereof to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. In certain embodiments, the Compounds of the Invention are useful for treating pain.

Claim (Index 82):
A compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein:\n R 1  is hydrogen, carboxamido, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, (cycloalkyl)alkyl, (cycloalkenyl)alkyl, (heterocyclo)alkyl, arylalkyl, heteroarylalkyl, (alkyl)carbonyl, (alkoxy)carbonyl, (arylalkoxy)carbonyl, or (heteroarylalkoxy)carbonyl, wherein each of said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, (cycloalkyl)alkyl, (cycloalkenyl)alkyl, (heterocyclo)alkyl, arylalkyl, heteroarylalkyl, (alkyl)carbonyl, (alkoxy)carbonyl, (arylalkoxy)carbonyl, and (heteroarylalkoxy)carbonyl is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of hydroxyl, alkyl, halo, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, aryl, heteroaryl, heterocyclo, biheterocyclo, cycloalkyl, bicycloalkyl, and cycloalkenyl; \n R 2  is hydrogen, \u2014OH, halo, cyano, carboxy, \u2014C(\u2550O)NH 2 , alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, or alkynyloxy, wherein any of said alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, and alkynyloxy is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of hydroxyl, halo, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxycarbonyl, aryl, heteroaryl, heterocyclo, biheterocyclo, cycloalkyl, and cycloalkenyl, \n R 3  is hydrogen, OH, halo, alkyl, alkoxy, alkylamino, or dialkylamino, any of said alkyl, alkoxy, alkylamino, and dialkylamino is optionally substituted with 1 or 2 substituents independently selected from the group consisting of hydroxyl, halo, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, aryl, heteroaryl, heterocyclo, cycloalkyl, and cycloalkenyl; \n R 4 , each independently, is H, \u2014OH, halo, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, aryl, cycloalkyl, heterocyclo, or heteroaryl, wherein each of said alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, aryl, cycloalkyl, heterocyclo, and heteroaryl is optionally substituted by one to three substituents independently selected from the group consisting of hydroxyl, halo, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, and aminocarbonyl; \n X is \u2014(CH 2 ) n \u2014, \u2014N(R 6 )\u2014, \u2014O\u2014, or \u2014S\u2014; \n The dash lines a and b, each independently, denote the presence or absence of a bond, and\n i) when the dashed line a denotes the presence of a bond, then R 5  is absent and W is \n \n \u2003and ii) when the dashed line a denotes the absence of a bond, then R 5  is H, \u2014OH, halo, alkyl, or carboxamido, wherein said alkyl is optionally substituted by one to three substituents independently selected from the group consisting of hydroxyl, halo, haloalkyl, amino, alkylamino, dialkylamino, carboxy, alkoxy, alkoxycarbonyl, and aminocarbonyl; and W is \u2014(CH 2 ) n \u2014, \u2014(CH 2 ) n \u2014N(R 6 )\u2014, \u2014(CH 2 ) n \u2014O\u2014, or \u2014(CH 2 ) n \u2014S\u2014, n, each independently, is 0, 1, or 2; y is 0, 1, or 2; m is 0, 1, 2, or 3; R 6  is H, alkyl, aminocarbonyl, alkenyl, alkynyl, (alkoxy)carbonyl, aryl, cycloalkyl, (cycloalkyl)alkyl, heterocyclo, or heteroaryl, wherein each of said alkyl, aminocarbonyl, alkenyl, alkynyl, (alkoxy)carbonyl, aryl, cycloalkyl, (cycloalkyl)alkyl, heterocyclo, and heteroaryl is optionally substituted by one to three substituents independently selected from the group consisting of hydroxyl, halo, haloalkyl, amino, alkylamino, dialkylamino, alkyl, carboxy, alkoxy, alkoxycarbonyl, aryl, heteroaryl, heterocyclo, cycloalkyl, and aminocarbonyl; and Z is \u2014C(O)\u2014 or \u2014CH 2 \u2014.

Metadata:
- Claim Count in Document: 31.0
- Percentile: 91.0
- Lexical Diversity: 1.73438
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15109161', '15108091', '14576718', '14138691', '15107023']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.829240365173592
- 35 USC 102 Novelty (BERT): 0.5455983731416452
- Combined Prediction Score: 0.8008761659703973
- Mean Citation Score: 353.67886
- Max Citation Score: 405.77823
- Similarity Product: 340.3407360157943

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test