PATENT CLAIM ANALYSIS

Application Number: 16235210
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-07
Patent Classification: ["514", "345000"]

Abstract:
Provided herein is a combination therapy comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog. The combination therapy is useful for the treatment of HBV infection. Also provided herein are compositions comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog.

Claim (Index 6):
A method of treating an HBV infection in a subject in need thereof, comprising administering to the subject peginterferon alfa-2a and a compound of Formula I: or a pharmaceutically acceptable salt thereof; wherein R 4  is H or C 1 -C 6  alkyl; wherein each R 5  is independently selected at each occurrence from the group consisting of CH 3 , C 1 -C 6  alkoxy, halo, \u2014CN, \u2014NO 2 , -(L) m -SR 9 , -(L) m -S(\u2550O)R 9 , -(L) m -S(\u2550O) 2 R 9 , -(L) m -NHS(\u2550O) 2 R 9 , -(L) m -C(\u2550O)R 9 , -(L) m -OC(\u2550O)R 9 , -(L) m CO 2 R 8 , -(L) m -OCO 2 R 8 , -(L) m -N(R 8 ) 2 , -(L) m -C(\u2550O)N(R 8 ) 2 , -(L) m -OC(\u2550O)N(R 8 ) 2 , -(L) m -NHC(\u2550O)NH(R 8 ), -(L) m -NHC(\u2550O)R 9 , -(L) m -NHC(\u2550O)OR 9 , -(L) m -C(OH)(R 8 ) 2 , -(L) m C(NH 2 )(R 8 ) 2 , \u2014C 1 -C 6  haloalkyl, \u2014C 1 -C 6  dihaloalkyl and \u2014C 1 -C 6  trihaloalkyl; L is independently, at each occurrence, a bivalent radical selected from \u2014(C 1 -C 3  alkylene)-, \u2014(C 3 -C 7  cycloalkylene)-, \u2014(C 1 -C 3  alkylene) m -O\u2014(C 1 -C 3  alkylene) m -, or \u2014(C 1 -C 3  alkylene) m -NH\u2014(C 1 -C 3  alkylene) m -; each R 8  is independently, at each occurrence, H, C 1 -C 6  alkyl, \u2014C 1 -C 6  haloalkyl, \u2014C 1 -C 6  dihaloalkyl, \u2014C 1 -C 6  trihaloalkyl, C 1 -C 6  heteroalkyl, C 3 -C 10  cycloalkyl, C 3 -C 10  heterocycloalkyl, aryl, heteroaryl, \u2014C 1 -C 4  alkyl-(C 3 -C 10  cycloalkyl), \u2014C 1 -C 4  alkyl-(C 3 -C 10  heterocycloalkyl), \u2014C 1 -C 4  alkyl-(aryl), or \u2014C 1 -C 4  alkyl(heteroaryl), and wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl is optionally substituted with 1-5 substituents selected from R 2 ; R 9  is C 1 -C 6  alkyl, \u2014C 1 -C 6  haloalkyl, \u2014C 1 -C 6  dihaloalkyl, \u2014C 1 -C 6  trihaloalkyl, C 1 -C 6  heteroalkyl, C 3 -C 10  cycloalkyl, a C 3 -C 10  heterocycloalkyl, aryl, heteroaryl, \u2014C 1 -C 4  alkyl-(C 3 -C 10  cycloalkyl), \u2014C 1 -C 4  alkyl-(C 3 -C 10  heterocycloalkyl), \u2014C 1 -C 4  alkyl-(aryl), or \u2014C 1 -C 4  alkyl-(heteroaryl), and wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring is optionally substituted with 0-5 substituents selected from R 2 ; R 10  is OH, C 1 -C 6  alkyl, C 1 -C 6  alkyl-OH, \u2014C 1 -C 6  haloalkyl, \u2014C 1 -C 6  dihaloalkyl, \u2014C 1 -C 6  trihaloalkyl, C 1 -C 6  heteroalkyl, C 3 -C 10  cycloalkyl, a C 3 -C 10  heterocycloalkyl, aryl, heteroaryl, C 4  alkyl-(C 3 -C 10  cycloalkyl), \u2014C 1 -C 4  alkyl-(C 3 -C 10  heterocycloalkyl), \u2014C 1 -C 4  alkyl-(aryl), or \u2014C 1 -C 4  alkyl-(heteroaryl), and wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring is optionally substituted with 1-5 substituents selected from R 2 ; R 11  is a bond or C 1 -C 3  alkylene, wherein the C 1 -C 3  alkylene is optionally substituted with 1-3 substituents selected from R 2 ; R 2  is independently selected at each occurrence from the group consisting of OH, halo, \u2014CN, \u2014NO 2 , \u2014C 1 -C 6  alkyl, \u2014C 1 -C 6  alkoxy, \u2014C 1 -C 6  haloalkyl, \u2014C 1 -C 6  dihaloalkyl, \u2014C 1 -C 6  trihaloalkyl, \u2014C 1 -C 6  heteroalkyl, and C(O)\u2014C 1 -C 6  alkyl; w is 0, 1 or 2; each occurrence of x is independently selected from the group consisting of 0, 1, 2, 3 and 4; each occurrence of y is independently selected from the group consisting of 1, 2, and 3; each occurrence of z is independently selected from the group consisting of 0, 1, 2, and 3; each occurrence of m is independently 0, 1 or 2.

Metadata:
- Claim Count in Document: 42.0
- Percentile: 98.0
- Lexical Diversity: 1.70968
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14541487', '15671499', '14801126', '15284807', '15612240']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8075002340870425
- 35 USC 102 Novelty (BERT): 0.5160051063535315
- Combined Prediction Score: 0.7783507213136915
- Mean Citation Score: 342.23141
- Max Citation Score: 345.6282
- Similarity Product: 293.18675391440394

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test