PATENT CLAIM ANALYSIS

Application Number: 16166359
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["424", "094500"]

Abstract:
The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.

Claim (Index 7):
An engineered polynucleotide encoding an engineered polypeptide comprising an amino acid sequence having at least 90% sequence identity to reference sequence SEQ ID NO:10, wherein said amino acid sequence comprises a glycine at position 290, and wherein said engineered polypeptide further comprises at least one or more of the following substitutions or substitution sets selected from 24, 24/381, 24/434, 27/39, 27/39/43/105/153/214/266/278/503, 27/39/43/214/547, 27/39/105/112/134/153/205/214/266/278/503/551, 27/39/105/112/134/214/278/503/547/565, 27/39/105/112/205/210/266/503/547, 27/39/105/112/205/266/285/503/551, 27/39/105/112/214/285/503/547, 27/39/105/131/134/205/214/503/547/565, 27/39/105/134/153/210/278/285/503/547/551, 27/39/105/134/205/210/278/503/547, 27/39/105/134/205/214, 27/39/105/134/205/214/551/565, 27/39/105/134/205/278/285/503/547/551/565, 27/39/105/134/210, 27/39/105/134/210/214, 27/39/105/134/210/214/285/547, 27/39/105/134/210/214/503/551/565, 27/39/105/134/214/278/547/551, 27/39/105/134/214/285/503/547/551, 27/39/105/134/266/503, 27/39/105/134/266/503/547/551, 27/39/105/134/278/285/503, 27/39/105/134/278/503/565, 27/39/105/134/278/551, 27/39/105/134/285/547/551, 27/39/105/134/503/551, 27/39/105/153/205/278/503/547/551, 27/39/105/153/214, 27/39/105/153/285, 27/39/105/153/503/547/565, 27/39/105/153/551/565, 27/39/105/205/210/214/278/547, 27/39/105/205/210/278/503, 27/39/105/205/210/278/547, 27/39/105/205/214/278/503/547, 27/39/105/205/278/503/547, 27/39/105/210/214/266/278, 27/39/105/210/285/503/547/551/565, 27/39/105/214/266/503/547/565, 27/39/105/214/278/309/503/547/551, 27/39/105/278/503/547/565, 27/39/105/285/547, 27/39/105/503/547/551/565, 27/39/105/503/551, 27/39/112/134/205/210/214/551/565, 27/39/112/134/214/266/551, 27/39/112/134/214/503/547, 27/39/112/134/266/285, 27/39/112/205/214/266/503/551/565, 27/39/112/205/278/285, 27/39/112/214, 27/39/112/214/278/503/547/551, 27/39/112/285, 27/39/112/547, 27/39/134, 27/39/134/153/205/214/266/503, 27/39/134/153/210/214/278/285/547/565, 27/39/134/153/214/266/278/503/547/565, 27/39/134/153/214/266/285/503/551/565, 27/39/134/153/214/503/547, 27/39/134/153/278, 27/39/134/153/278/547/551, 27/39/134/153/547, 27/39/134/205/214/266/285/503/551/565, 27/39/134/205/266/503/551/565, 27/39/134/210/214/503, 27/39/134/210/503/551, 27/39/134/214/266/551, 27/39/134/278/285/503/547/551, 27/39/134/278/503/547, 27/39/134/503/547, 27/39/134/547/565, 27/39/205/214/503/565, 27/39/205/266/285/547/551/565, 27/39/205/266/551, 27/39/205/278/503/551/565, 27/39/205/278/503/565, 27/39/205/503/547/565, 27/39/210/212, 27/39/210/214/278/503/551, 27/39/210/214/285/503/551, 27/39/210/266/285/503/547, 27/39/210/266/503/551, 27/39/214, 27/39/214/266/278/503/547/551/565, 27/39/214/278/503, 27/39/214/278/503/547/565, 27/39/214/503/551, 27/39/266, 27/39/266/278, 27/39/278, 27/39/278/285/503/547, 27/39/278/503/565, 27/39/278/547, 27/39/503, 27/45/205/266/565, 27/105, 27/105/134/153/210/214/503/547, 27/105/134/153/285/547, 27/105/134/153/503, 27/105/134/205/210/503, 27/105/134/205/214/266/278/503/565, 27/105/134/210/214/266/278/551/565, 27/105/134/210/214/503/551/565, 27/105/134/210/266/278/285/503/551/565, 27/105/134/214/278/503/547, 27/105/134/214/278/503/547/551/565, 27/105/205, 27/105/205/214/266, 27/105/205/214/266/551/565, 27/105/205/214/278/285/503/547/551/565, 27/105/205/266/503, 27/105/205/503/547/551/565, 27/105/214, 27/105/214/266/503, 27/105/214/285/551/565, 27/105/214/547/551/565, 27/105/214/551/565, 27/105/266, 27/105/266/285/503/547/565, 27/105/278/547, 27/105/285/503/547/551/565, 27/105/503/547/551/565, 27/105/503/547/565, 27/112/134/153/214/266/503, 27/112/134/205/278/503, 27/112/134/205/285/503, 27/112/134/278/285/503/551/565, 27/112/205/266/278/285/503, 27/112/210/214/503/547, 27/134, 27/134/153/285/503/547, 27/134/205/266/278/547, 27/134/205/285/503/551, 27/134/210, 27/134/214/503, 27/134/214/503/547, 27/134/214/503/547/551, 27/134/214/503/565, 27/134/278/285/551/565, 27/134/285/503, 27/153/214/278/285/551/565, 27/153/214/278/551, 27/205, 27/205/214/278/285/503/565, 27/205/214/503/547/565, 27/205/266/278/285/551/565, 27/205/278/551, 27/210, 27/210/214/503/547, 27/210/278/503, 27/210/503, 27/210/503/565, 27/210/551, 27/214, 27/214/266/278/285/551, 27/214/278, 27/214/278/503, 27/214/503, 27/214/503/547, 27/214/503/547/565, 27/214/551, 27/266/278/503, 27/266/547/551, 27/278/503/551, 27/278/503/551/565, 27/547/565, 39/45/278/503/551, 39/105/134/153/205/551, 39/105/134/210/214/551, 39/105/134/214/503/547/551, 39/105/153/266/547/551, 39/105/205/503, 39/105/205/551, 39/105/210/547, 39/105/214/266/547/565, 39/105/214/285/503/551/565, 39/112/134/205/214/278, 39/112/134/214/503/547/551, 39/112/153/205/278/503/547, 39/115/133/565, 39/133/472/503/565, 39/133/472/565, 39/133/503, 39/133/503/565, 39/134, 39/134/205/214/503/565, 39/134/210/214/547/565, 39/147/378/503/565, 39/147/378/565, 39/147/381/472/503/565, 39/147/381/503/565, 39/147/472/503/565, 39/147/472/565, 39/147/565, 39/153/503/547, 39/205/278/547/551, 39/210/214/278/285/503/551, 39/248/381/472/503/565, 39/266, 39/275/278/503/551, 39/378/503/565, 39/378/565, 39/381, 39/472/503/565, 39/503, 39/503/551/565, 39/503/565, 43/374, 58/475, 62/433, 70/474, 80/134/564, 98, 104/476, 105, 105/112/134/205/214/492/503/547, 105/134/153/205/214/503, 105/134/205/214/547, 105/134/205/266/278, 105/134/214/266/285/503/551/565, 105/134/214/278/565, 105/134/214/503/547, 105/134/214/503/547/551, 105/134/503, 105/134/503/547, 105/134/503/547/565, 105/153/205/214/266/503/547, 105/153/205/266/285/547/565, 105/205/210/214/503/547, 105/205/214/278, 105/205/214/503/547/551/565, 105/205/503/551, 105/214/266/278/547, 105/214/278/503/547/551, 105/214/285, 105/214/285/503/547/551/565, 105/214/285/547/565, 105/278/503/551, 105/285, 105/285/547, 105/503, 105/547/551, 112/134/153/214/278/285/503/547/551/565, 112/134/214/503/547/551/565, 112/214/278, 112/278/503/547, 112/370/507, 117/176, 119/365, 121, 123, 124, 125, 126, 127, 129, 130, 130/370, 131, 132, 133, 133/381/565, 133/503, 134, 134/205/214/285/503/551/565, 134/205/503, 134/210/214/278/503/547/565, 134/210/214/503/547/551, 134/214, 134/214/278/503, 134/214/278/503/551, 134/214/285/503, 134/307, 134/378/381, 134/378/381/388, 134/388, 134/503, 134/503/547/551, 135, 135/394, 136, 147/374, 153, 172, 174, 175, 176, 177, 178/477, 180, 187/381, 191/385, 205/214/285/503/551, 205/214/285/503/565, 205/214/503/547/565, 205/278/285/547/551, 206, 210/214, 210/214/266, 213/438, 214/266, 214/266/503/547/551/565, 214/503/547, 214/547, 232, 240/374, 240/433, 256/381, 266/278/503, 266/565, 275, 275/370, 275/374, 276, 278/547, 286/435, 289, 289/431, 292/479, 331, 332/377, 334/374, 349, 355/374, 355/478, 370, 371, 372, 374, 374/396, 374/417, 375, 377, 378, 378/404, 378/472/503/565, 378/503, 379, 381, 381/472/503/565, 381/560, 382, 383, 384, 385, 385/403, 387, 388, 404/477, 418, 425, 431, 432, 433, 434, 435, 435/446, 436, 437, 437/538, 438, 439, 447, 461, 471, 472, 472/503/565, 473, 473/507, 474, 474/490, 475, 476, 477, 478, 479, 482, 483, 483/524, 483/537, 503, 503/547, 503/547/551/565, 503/547/565, 503/551, 503/551/565, 525, 547, 558, 563, and 565, wherein said positions in said amino acid sequence are in reference to SEQ ID NO:10.

Metadata:
- Claim Count in Document: 75.0
- Percentile: 97.0
- Lexical Diversity: 1.38095
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15431491', '15720198', '14255539', '15720060', '14688126']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8567541911255578
- 35 USC 102 Novelty (BERT): 0.8232954090885489
- Combined Prediction Score: 0.853408312921857
- Mean Citation Score: 936.91942
- Max Citation Score: 1245.8074
- Similarity Product: 1084.608740358722

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test