PATENT CLAIM ANALYSIS

Application Number: 15906667
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-12
Patent Classification: ["435", "018000"]

Abstract:
Conjugates of 2,3-dihydroxynaphthalene and its derivatives with enzyme cleavable groups are chromogenic substrates that form coloured compounds when complexed with metal ions, e.g. iron ions, on cleavage by enzymes, and are useful in microbial detection and identification. The cleavage products form purple or red-brown coloured complexes, that can easily be observed by the naked eye. Microbes can be grown in the presence of the substrates and the metal salts that provide the metal ion for complexing with the 2,3-dihydroxynaphthalene product. Substituents in the naphthalene ring may affect the solubility of the substrates and also the diffusibility and colour of the metal complexes. Some of the substrates yield soluble complexes on cleavage and are of particular value in liquid growth media. Other substrates produce less soluble complexes that are more suitable for use in solid agar media. Some substrates are new compounds, such as those having the general formula II wherein one of the following applies i) m=0, R 4 =R 5 =Z 1 =H, Y 1  is selected from the group consisting of D-glucuronyl and D-ribofuranosyl; ii) m=2, each R 6  is Br, R 4 =R 5 =H or Br, Z 1 =H, Y 1  is glycosyl or phosphate; iii) m=1, R 6  is —SO 3 X, X is H or M +  wherein M +  is an alkali metal cation or a non-metal cation, Y 1  is glycosyl and R 4 =R 5 =Z 1 =H; iv) m=0, R 4 =NO 2 , R 5 =Z 1 =H, Y 1 =glycosyl. Methods of synthesising the substrates are described.

Claim (Index 27):
The composition according to  claim 25 , further comprising microbial growth nutrients.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 88.0
- Lexical Diversity: 2.07857
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15035152', '15035136', '10493472', '10493483', '12104916']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.585210580836177
- 35 USC 102 Novelty (BERT): 0.5654666928514636
- Combined Prediction Score: 0.5832361920377057
- Mean Citation Score: 337.9257580000001
- Max Citation Score: 525.4043
- Similarity Product: 309.1718192610383

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test