PATENT CLAIM ANALYSIS

Application Number: 16212287
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["435", "189000"]

Abstract:
The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.

Claim (Index 1):
A method of production of isopulegol of general formula (I) comprising cyclizing citronellal of general formula (II) to isopulegol of formula (I) by means of an enzyme mutant with cyclase activity which is a mutant of a wild-type enzyme comprising the amino acid sequence of SEQ ID NO: 209 with a mutation at a position corresponding to position F445 of the amino acid sequence of SEQ ID NO: 209, wherein up to 10% of the amino acid residues in said enzyme mutant are altered relative to SEQ ID NO: 209 by deletion, insertion, substitution, addition, inversion, or a combination thereof, and wherein said enzyme mutant catalyzes at least the cyclization of a citronellal isomer to at least one isopulegol isomer, or in the presence of a microorganism expressing said enzyme mutant.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 98.0
- Lexical Diversity: 1.40476
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13297798', '15234529', '14560263', '13798365', '15514706']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5837876926791504
- 35 USC 102 Novelty (BERT): 0.6061225320477847
- Combined Prediction Score: 0.5860211766160138
- Mean Citation Score: 361.44513
- Max Citation Score: 522.1857
- Similarity Product: 499.3473027787506

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test