PATENT CLAIM ANALYSIS

Application Number: 15985060
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "001900"]

Abstract:
The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R 1 , R 2 , R 3 , R 4 , Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Claim (Index 9):
The method according to  claim 1 , wherein the biomolecule linked to the fatty acid via a linker has one of the following Formulae: wherein in Formulae C and D, both monomeric units of his-hGDF15 or of hGDF15* are linked to the fatty acid moiety via a linker at the N-terminus of each his-hGDF15 monomeric unit and at the N-terminus of each hGDF15* monomeric unit; wherein in Formulae E and F, only one of the monomeric unit of his-hGDF15 or of hGDF15* is linked to the fatty acid moiety via a linker at the N-terminus; wherein in Formulae D and F, hGDF15* is hGDF15 wherein the 2 or 3 amino acids at the N-terminus have been replaced with an amino acid sequence XH\u2014 or XHX\u2032\u2014 respectively, wherein H is histidine and X and X\u2032 are independently selected from M and A; wherein in Formulae C and E, his-hGDF15 is hGDF15 wherein a tag, comprising 1 to 6 histidine amino acids and optionally 1 or 2 methionine amino acids, has been added to the N-terminus of hGDF15; and wherein in Formulae C, D, E, and F, s is an integer between 20-30; and the line between the 2 monomeric units of his-hDGF15 or the 2 monomeric units of hGDF15* represent a disulfide bond.

Metadata:
- Claim Count in Document: 34.0
- Percentile: 93.0
- Lexical Diversity: 1.74038
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14738272', '14336262', '14996418', '14905338', '14905333']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7924421551292801
- 35 USC 102 Novelty (BERT): 0.6055744335048318
- Combined Prediction Score: 0.7737553829668352
- Mean Citation Score: 305.8291240000001
- Max Citation Score: 509.15088
- Similarity Product: 495.0470329062938

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test