PATENT CLAIM ANALYSIS

Application Number: 15900061
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-08
Patent Classification: ["435", "006100"]

Abstract:
The subject invention provides methods, assays, and products for detecting small molecules in a sample, in particular, in both clinical and field settings. The method for detecting a small-molecule target, preferably, a synthetic cathinone in a sample comprises contacting the sample with an aptamer-based sensor selective for the small-molecule target, and detecting the small-molecule target in the sample. Specifically, the method utilizes an aptamer-based sensor comprising a dye binding to a three-way junction binding domain of an aptamer. Binding of small-molecule target to the aptamer displaces the dye, generating a spectroscopic signal that can be used for detection of the small-molecule target and quantitative measurement of the target concentration.

Claim (Index 15):
An aptamer library comprising a nucleic acid sequence that forms a structure comprising three stems and a three-way junction (TWJ) binding domain when binding to a small-molecule target, the small-molecule target binding within the TWJ-binding domain, and the TWJ-binding domain comprising 10 random nucleotides.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 88.0
- Lexical Diversity: 2.03333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14930242', '13092209', '11645362', '15878021', '13651265']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5428387525461595
- 35 USC 102 Novelty (BERT): 0.5160900930113119
- Combined Prediction Score: 0.5401638865926748
- Mean Citation Score: 249.76982
- Max Citation Score: 270.09644
- Similarity Product: 170.50939590721606

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test