PATENT CLAIM ANALYSIS

Application Number: 16191319
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "309000"]

Abstract:
The present disclosure relates generally to compositions and methods of treating neoplastic diseases or cancers, such as glioblastoma and non-Hodgkin's lymphomas, or other cancers in which the subject suffers from an advanced solid tumor, comprising a combination of, or administering a combination of, a bromodomain and extra-terminal protein (BET) inhibitor and at least one chemotherapeutic agent, which does not inhibit BET directly. The BET inhibitor/chemotherapeutic agent combination, or combination therapy, can yield synergistic effects, thereby increasing the effectiveness of the cancer treatment as compared with the administration of either the BET inhibitor or the chemotherapeutic agent alone.

Claim (Index 5):
A method for treating cancer or neoplastic disease comprising administering to a human patient a therapeutically effective amount of at least one bromodomain and extra-terminal protein (BET) inhibitor and at least one chemotherapeutic agent, which does not inhibit BET directly, wherein the BET inhibitor has the structure of Formula II, or a pharmaceutically acceptable salt thereof, wherein R 2  is alkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl, or heteroarylalkyl; X5 is C\u2014R 5  or N; wherein\n R 5  is hydrogen, halogen, OH, CN, OR 61 , NHR 61 , N(R 61 ) 2 , alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, wherein\n each R 61  is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; \n \n X6 is C\u2014H or N, provided that if X6 is N, then X5 is C\u2014R 5 , and if X5 is N, then X6 is CH; R 6  is hydrogen, halogen, OH, CN, alkyl, cycloalkyl, cycloalkylalkyl, amino, alkylamino, dialkylamino, cycloalkylalkylamino, alkoxy, S-alkyl, cycloalkylalkoxy, heterocyclyl, aralkoxy, heteroaryloxy, aryloxy, alkynyloxy, or N(H)COalkyl; R A  is in which\n X2 is N or C\u2014R 12 , wherein R 12  is hydrogen, halogen, alkyl, or alkoxy; \n R 13  is \u2014Y\u2014Z, wherein\n Y is selected from a bond, \u2014CH 2 \u2014, or \u2014CH(C 1 -C 4  alkyl)-, and \n Z is selected from \u2014SO 2 R 21 , \u2014N(R 22 )SO 2 R 21 , \u2014SO 2 N(R 22 ) 2 , \u2014N(R 22 )SO 2 N(R 22 ) 2 , \u2014CON(R 22 ) 2 , \u2014N(R 22 )CO 2 R 21 , \u2014N(R 22 )CON(R 22 ) 2 , \u2014N(R 22 )COR 21 , \u2014COR 21 , \u2014OC(O)N(R 22 ) 2 , \u2014OSO2N(R 22 ) 2 , or \u2014N(R 22 )SO 3 R 21 ;\n each R 21  is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and \n each R 22  is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; \n \n \n X3 is N or C\u2014R 14 , wherein R 14  is hydrogen, halogen, \u2014CN, alkyl, cycloalkyl, or alkoxy; and \n X4 is N or C\u2014R 15 , wherein R 15  is hydrogen, halogen, alkyl, \u2014CN, or alkoxy; and\n R 16  is hydrogen, halogen, N(H)COX, or W\u2014X, wherein W is a bond, O, S, or NH, and X is selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, alkynyl, cycloalkylalkynyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; provided that when X6 is N, then R 5  and R 6  are not hydrogen.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 98.0
- Lexical Diversity: 1.58571
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15796571', '15673084', '11724992', '13321213', '13357477']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7729382780869578
- 35 USC 102 Novelty (BERT): 0.6079355982825083
- Combined Prediction Score: 0.7564380101065129
- Mean Citation Score: 356.599036
- Max Citation Score: 558.2782599999998
- Similarity Product: 488.3233041517137

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test