PATENT CLAIM ANALYSIS

Application Number: 16139091
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["514", "04400A"]

Abstract:
Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Claim (Index 49):
An oligonucleotide having the structure of WV-3546:\n Mod020L001fU*SfC*SfA*SfA*SfG*SfG*SmAfA*SmGmA*SfU*SmGmGfC*SfA*SfU*SfU*SfU*SfC*SfU (SEQ ID NO: 839), or a pharmaceutically acceptable salt thereof, wherein:\n Mod020 is connected to L001 through a \u2014C(O)\u2014 group: \n wherein the \u2014C(O)\u2014 group connects to L001; L001 is \u2014NH\u2014(CH 2 ) 6 \u2014, wherein the \u2014NH\u2014 group is connected to Mod020 through the \u2014C(O)\u2014 group, and \u2014(CH 2 ) 6 \u2014 is connected to the 5\u2032-end of the oligonucleotide chain through a phosphodiester linkage; f represents a 2\u2032-F modified nucleoside; *S represents a Sp phosphorothioate; and m represents a 2\u2032-OMe modified nucleoside.

Metadata:
- Claim Count in Document: 83.0
- Percentile: 97.0
- Lexical Diversity: 2.34146
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15746220', '15112146', '14414614', '15462787', '14344523']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7954278876082415
- 35 USC 102 Novelty (BERT): 0.6032336213342909
- Combined Prediction Score: 0.7762084609808464
- Mean Citation Score: 423.300848
- Max Citation Score: 600.9497
- Similarity Product: 422.8702187069297

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test