PATENT CLAIM ANALYSIS

Application Number: 15973718
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-05
Patent Classification: ["435", "194000"]

Abstract:
Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFC). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides.

Claim (Index 23):
The composition of  claim 21 , wherein said biological sample is a serum, pleural effusion, or tissue biopsy sample.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.74227
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14870154', '15225998', '15096562', '14483668', '12584353']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.696636246635309
- 35 USC 102 Novelty (BERT): 0.6181671061821374
- Combined Prediction Score: 0.6887893325899918
- Mean Citation Score: 546.3088740000002
- Max Citation Score: 680.7647
- Similarity Product: 476.9533440174937

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test