PATENT CLAIM ANALYSIS

Application Number: 16065441
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "269000"]

Abstract:
Compositions and methods are provided for treating, ameliorating, and preventing anesthesia-induced hypothermia and/or postsurgical associated hyperalgesia in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.

Claim (Index 7):
The method according to  claim 1 , wherein the TRPV1 inhibitor is selected from the group consisting of: AMG 517, SB-366791, AMG 9810, civamide (zucapsaicin), ABT-102, GRC-6211, AZD1386, SB-705498, NGD 8243/MK-2295, JTS-653, JYL1421, JNJ 17203212, SAR-115740, KJM429, capsazepine, N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)-tetrahydropyrazine-1 (2H)-carboxamide; N-(3-Methoxyphenyl)-4-chlorocinnamide; 1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea; (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide; 2-Acetylamino-4-[6\u2032-(4-trifluoromethylphenyl)-pyrimidin-4\u2032-yl-oxy]-benzothiazole; N-(2-bromophenyl-N\u2032-[((R)-1-(5-trifluoromethyl-2-pyridyl)pyrrolidin-3-yl)]urea; N-(2-bromophenyl)-N\u2032-{2-[ethyl(3-methylphenyl)amino]ethyl}urea; (R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea; N-(Isoquinolin-5-yl)-N\u2032-[spiro-(cyclobutane-1,2\u2032-(3\u2032,4\u2032-dihydro-benzopyran-4\u2032-yl))]urea; (2R)-4-(3-chloro-2-pyridinyl)-2-methyl-N-[4-(trifluoromethyl)phenyl]-1-piperazinecarboxamide; 4-(4\u2032-Trifluoromethyl-anilino)-7-(3\u2032-trifluoromethyl-pyridin-2-yl)-quinazoline; N-[2-(4-chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide; (5R*,8R*,6E,9E)-5,8-Dimethyl-4-methylenetetradeca-6,9-dienoic acid; 1-(3-Fluorobenzyl)-2-(N-(1,2-dimethyl-1,3-isoindazol-5-yl)-acetamido)-{pyridine-[3,4-b]-pyrrole}; N-(4-chlorobenzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)urea; N-(4-tert-butylbenzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)urea; N-(3-fluoro-4-(trifluoromethyl)benzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)-urea; N-(4-fluoro-3-(trifluoromethyl)benzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)-urea; N-(3,4-dichlorobenzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)urea; N-(2,4-dichlorobenzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)urea; N-(4-ethylbenzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)urea; N-(2-chlorobenzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)urea; N-(4-fluorobenzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)urea; N-(2-fluorobenzyl)-N\u2032-(1-methyl-1H-indazol-4-yl)urea; N-[1-(bromophenyl)ethyl-N\u2032-(1-methyl-1H-Indazol-4-yl)urea; N-(1-methyl-1H-indazol-4-yl)-N\u2032-{4-[(trifluoromethyl)thio]benzyl}urea; 1-(2,3-dichlorophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea; 1-[2-(N-ethyl-3-methylanilino)ethyl]-3-naphthalen-1-ylurea; 1-(4-bromophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea; 1-(3-bromophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea; 1-(chlorophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea; 1-[2-(N-ethyl-3-methylanilino)ethyl]-3-(2-fluorophenyl)urea; 1-[2-{N-ethyl-3-methylanilino)ethyl]-3-(2-methylphenyl)urea; 1-[2-(N-ethyl-3-methylanilino)ethyl]-3-phenylurea; 2-[(2-bromophenyl)carbamoylamino]ethyl-ethylmethyl-(3-methylphenyl)azanium iodide; 1-(2-bromophenyl)-3-[2-(N-ethyl-3-fluoro-4-methylanilino)ethyl]urea; 1-(2-bromophenyl)-3-[2-(N-ethyl-3,4-difluoroanilino)ethyl]urea; 1-(2-bromophenyl)-3-[2-(N-ethyl-3-fluoroanilino)ethyl]urea; 1-(2-bromophenyl)-3-[2-(N-ethyl-4-methylanilino)ethyl]urea; 1-(2-bromophenyl)-3-[2-(N-ethyl-2-methylanilino)ethyl]urea; 1-(2-bromophenyl)-3-[2-(N-ethylanilino)ethyl]urea; N-[2-[(2-bromophenyl)carbamoylamino]ethyl]-N-(3-methylphenyl)acetamide; 1-[2-{N-benzyl-3-methylanilino)ethyl]-3-(2-bromophenyl)urea; 1-(2-bromophenyl)-3-[2-(2,3-dimethylanilino)ethyl]urea; 1-(2-bromophenyl)-3-[2-(3-methylanilino)ethyl]urea; 1-(2,5-dichlorophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea; 4-fluoro-4-(3-methylpyridin-2-yl)-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 4-fluoro-4(pyridin-2-yl)N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 4-fluoro-4(pyridine-2-yl)N-[4-trifluoromethylbenzyl]piperidine-1-carboxamide; 2-{4-fluoro-1-[4-trifluoromethylbenzoyl]piperidin-4-yl}pyridine; 2-(4-fluoro-1-{[4-trifluoromethylphenyl]acetyl}piperidin-4-yl)pyridine; 2-(4-fluoro-1-{3-[4-trifluoromethylphenyl]propanoyl}piperidin-4-yl)pyridine; 4-fluoro-4-(1-methyl-1H-imidazol-2-yl)-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 4-methoxy-4-pyridin-2-yl-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 4-methoxy-4-pyridin-2-yl-N-[4-trifluoromethylbenzyl]piperidine-1-carboxamide; 4-fluoro-N-(4-isopropylphenyl)-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; 4-fluoro-4-(3-methylpyridin-2-yl)-N-{4-[1,2,2,2-tetrafluoro-1-trifluoromethylethyl]phenyl}piperidine-1-carboxamide; N-(4-Tert-butylphenyl)-4-fluoro-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; 4-fluoro-4-(3-methylpyridin-2-yl)-N-[4-(pentafluoro-lambda(sup 6)-sulfanyl)phenyl]piperidine-1-carboxamide; N-(4-Butylphenyl)-4-fluoro-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; N-(4-Benzylphenyl)-4-fluoro-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; N-biphenyl-4-yl-4-fluoro-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; 4-fluoro-4-(3-methylpyridin-2-yl)-N-[5-trifluoromethylpyridin-2-yl]piperidine-1-carboxamide; 4-(3-chloropyridin-2-yl)-4-fluoro-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 4-fluoro-4-(3-fluoropyridin-2-yl)-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 4-fluoro-4-(3-methoxypyridin-2-yl)-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 4-fluoro-4-(3-methylpyridin-2-yl)-N-[4-trifluoromethylphenyl]piperidine-1-carbothioamide; N\u2032-cyano-4-fluoro-4-(3-methylpyridin-2-yl)-N-[4-trifluoromethylphenyl]piperidine-1-carboximidamide; 4-fluoro-4-(3-methylpyridin-2-yl)-N\u2032-(1-phenylpiperidin-4-yl)-N-[4-trifluoromethylphenyl]piperidine-1-carboximidamide; 4-fluoro-4-phenyl-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; (+/\u2212)-(syn)-4-fluoro-2-methyl-4-(3-methylpyridin-2-yl)-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 4-(fluoromethyl)-4-pyridin-2-yl-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; syn- and anti-3-fluoro-3-pyridin-2-yl-N-[4-trifluoromethylphenyl]-8-azabicyclo[3.2.1]octane-8-carboxamide; 3-fluoro-3-pyridin-2-yl-N-[4-trifluoromethylphenyl]-8-azabicyclo[3.2.1]octane-8-carboxamide; 4-fluoro-4-pyrimidin-2-yl-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 4-fluoro-4-(3-phenylpropyl)-N-[4-trifluoromethylphenyl]piperidine-1-carboxamide; 2-[4-fluoro-4-(3-methylpyridin-2-yl)piperidin-1-yl]-6-trifluoromethyl-1H-benzimidazole; 2-(4-fluoro-4-pyridin-2-ylpiperidin-1-yl)-6-(trifluoromethyl)-1H-benzimidazole; 4-fluoro-N-[4-trifluoromethyiphenyl]-4-[3-trifluoromethylpyridin-2-yl]piperidine-1-carboxamide; 4-fluoro-N-(4-methylphenyl)-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; N-(4-ethylphenyl)-4-fluoro-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; N-(4-chlorophenyl)-4-fluoro-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; 4-fluoro-4-(3-methylpyridin-2-yl)-N-[4-trifluoromethoxyphenyl]piperidine-1-carboxamide; N-(4-cyanophenyl)-4-fluoro-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; N-[4-dimethylaminophenyl]-4-fluoro-4-(3-methylpyridin-2-yl)piperidine-1-carboxamide; 1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl)-3-(1-methyl-1H-indazo-1-4-yl)urea; N-acetyl-1-phenylalanyl-1-leucinamide; and pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 1.12121
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15583867', '13824912', '13509442', '14785812', '12455798']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8089153981342705
- 35 USC 102 Novelty (BERT): 0.5615797345915485
- Combined Prediction Score: 0.7841818317799983
- Mean Citation Score: 369.960882
- Max Citation Score: 439.60556
- Similarity Product: 340.64375383235694

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test