PATENT CLAIM ANALYSIS

Application Number: 15780398
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "275000"]

Abstract:
The disclosure includes a method of inducing direct reprogramming (transdifferentiation) into non-oncogenic cells accompanied by tumor cell apoptosis in human tumor cells using a small molecule composition, based on the mechanism of chemical-induction of direct cellular reprogramming. The disclosure also includes a small molecule composition used for the method, and culture media and agents prepared from the composition.

Claim (Index 12):
The composition of any one of  claims 1 - 8 , the use of  claim 9 , the method of  claim 10  and the kit of  claim 11 , wherein the tumors or tumor cells include but are not limited to: liver cancer, lung cancer, stomach cancer, colorectal cancer, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, osteosarcoma, lymphoma, leukemia, nasopharyngeal cancer, esophageal cancer, cervical cancer, oral cavity cancer, salivary gland tumor, nasal cavity and paranasal cavity sinus malignant tumor, laryngeal cancer, otic tumor, ocular tumor, thyroid tumor, mediastinal tumor, thoracic wall and pleural tumor, intestinal tumor, biliary tract tumor, pancreatic and periampullary tumor, mesenteric and retroperitoneal tumor, renal tumor, adrenal tumor, bladder tumor, testicular tumor, penile cancer, endometrial cancer, ovarian malignant tumor, malignant trophoblastic tumor, vulvar and vaginal cancer, malignant lymphoma, multiple myeloma, soft tissue tumor, bone tumor, skin and adnexal tumor, malignant melanoma or nervous system tumors and other hematological and solid tumors or cells thereof; preferably liver cancer or hepatoma cells.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 93.0
- Lexical Diversity: 1.48837
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13697274', '15376536', '13704214', '15446552', '15072769']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7781706525735425
- 35 USC 102 Novelty (BERT): 0.5164922083637635
- Combined Prediction Score: 0.7520028081525646
- Mean Citation Score: 247.068706
- Max Citation Score: 257.53943
- Similarity Product: 152.13950940137389

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test