PATENT CLAIM ANALYSIS

Application Number: 15942333
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "211080"]

Abstract:
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Claim (Index 5):
The compound of  claim 4 , wherein R 2  is: wherein R 6 , R 7 , and R 5  are each independently selected from the group consisting of:\n i. branched or linear C 1-6  alkyl, C 1-6  alkenyl, or C 1-6  alkenylene, wherein said alkyl, alkenyl and alkenylene can be optionally substituted with one to four substituents independently selected from the group consisting of hydroxyl, halogen, nitrile, amino, mono(C 1-6 a 1 kyl)amino-, di(C 1-6 alkyl)amino-, \u2014SO 2 R y , \u2014S(O)NR y , \u2014(CO)NR y R z  and \u2014NR y (CO)R z , wherein R y  and R z , in each instance, is independently hydrogen or C 1-6  alkyl, wherein said alkyl can optionally be substituted with one to four substituents independently selected from the group consisting of hydroxyl and halogen; \n ii. NR y R z \u2014C(O)\u2014, wherein R y  and R z  are each independently hydrogen or C 1-6  alkyl, wherein said alkyl can optionally be substituted with one to four substituents independently selected from the group consisting of hydroxyl and halogen; \n iii. hydroxy(C 1-6  alkyl); \n iv. C 1-6  alkoxy, wherein said alkoxy can be optionally substituted with one to four substituents independently selected from the group consisting of hydroxyl and halogen; \n v. C 3-9  cycloalkyl, substituted or unsubstituted C 6  aryl, substituted or unsubstituted 5-membered heteroaryl, or C 2-9  heterocyclyl; \n vi. halogen; \n vii. amino; \n viii. cyano; \n ix. \u2014NR y C(O)R z , wherein R y  and R z  are each independently hydrogen or C 1-6  alkyl, wherein said alkyl can optionally be substituted with one to four substituents independently selected from the group consisting of hydroxyl and halogen; \n x. \u2014SO 2 R\u2032, wherein R\u2032 is H or C 1-6  alkyl; \n xi. \u2014SO 2 NR\u2032R\u2033, wherein R\u2032 and R\u2033 are independently H or C 1-6  alkyl; \n xii. \u2014NR\u2032C(O)OR\u2033, \u2014NR\u2032SO 2 NR\u2033 or \u2014NR\u2032S(O)R\u2033, wherein R\u2032 is independently H or C 1-6  alkyl and R\u2033 is independently C 1-6  alkyl, halo(C 1-6  alkyl) or C 6-10  aryl optionally substituted with C 1-6  alkyl; and \n xiii. wherein a carbon embedded in said heterocyclyl taken together with an oxygen to which it is bound can form a carbonyl.

Metadata:
- Claim Count in Document: 104.0
- Percentile: 90.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15942321', '15698788', '13266976', '15852639', '14428546']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8064244706493195
- 35 USC 102 Novelty (BERT): 0.5299126567395208
- Combined Prediction Score: 0.7787732892583397
- Mean Citation Score: 281.45004400000005
- Max Citation Score: 362.283
- Similarity Product: 327.4286368634105

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test