PATENT CLAIM ANALYSIS

Application Number: 16151597
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-01
Patent Classification: ["514", "089000"]

Abstract:
Compounds of formula (I) wherein: Ak 1  represents an alkyl chain, X represents —(CH 2 ) m —, —CH(R)—, —N(R)—, —CH 2 —N(R)—, N(R)—CH 2 — or —CH 2 —N(R)—CH 2 —,      m and R are as defined in the description,       R 1  and R 2  each represent H when X represents —(CH 2 ) m —, —CH(R)—, —N(R)—, —CH 2 —N(R)— or —N(R)—CH 2 —, or together form a bond when X represents —CH 2 —N(R)—CH 2 —, R 3  represents NH 2 , Cy-NH 2 , Cy-Ak 3 -NH 2  or piperidin-4-yl,      Cy and Ak 3  are as defined in the description,       R 4  and R 5 , which may be identical or different, each represent H or F, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid.  Medicinal products containing the same which are useful in treating conditions requiring a TAFIa inhibitor.

Claim (Index 1):
A method of treating or preventing a condition requiring a TAFIa inhibitor in a subject in need thereof, comprising administration of an effective amount of a compound of formula (I): wherein:\n Ak 1  represents a C 1 -C 6 -alkyl chain; \n X represents \u2014(CH 2 ) m \u2014, \u2014CH(R)\u2014, \u2014N(R)\u2014, \u2014CH 2 \u2014N(R)\u2014, \u2014N(R)\u2014CH 2 \u2014 or \u2014CH 2 \u2014N(R)\u2014CH 2 \u2014;\n m represents 0 or an integer from 1 to 4; \n \n R represents a hydrogen atom, C 1 -C 6 -alkyl, -Ak 2 -Ar 1 , -Ak 2 -Ar 1 -Ar 2 , Ak 2 -Ar 1 -O-Ar 2 , -Ak 2 -cycloalkyl or -Ak 2 -OH; \n Ak 2  represents a linear or branched C 1 -C 6 -alkyl chain; \n Ar 1  and Ar 2 , which may be identical or different, each represent an aryl or heteroaryl group; \n R 1  and R 2  each represent a hydrogen atom when X represents \u2014(CH 2 ) m \u2014, \u2014CH(R)\u2014, \u2014N(R)\u2014, \u2014CH 2 \u2014N(R)\u2014 or N(R)\u2014CH 2 \u2014, \n or together form a bond when X represents \u2014CH 2 \u2014N(R)\u2014CH 2 \u2014; \n R 3  represents NH 2 , Cy-NH 2 , Cy-Ak 3 -NH 2  or piperidin-4-yl; \n Cy represents cycloalkyl, aryl or heteroaryl; \n Ak 3  represents a C 1 -C 3 -alkyl chain; \n R 4  and R 5 , which may be identical or different, each represent a hydrogen atom or a fluorine atom; \n its optical isomers, or addition salts thereof with a pharmaceutically acceptable acid, wherein the compound of formula (I) is administered alone or in combination with one or more inert, non-toxic, pharmaceutically acceptable excipients or carriers.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 97.0
- Lexical Diversity: 2.81579
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15548533', '12803405', '12291485', '11395747', '12809555']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7424014662068964
- 35 USC 102 Novelty (BERT): 0.6068074305899381
- Combined Prediction Score: 0.7288420626452006
- Mean Citation Score: 367.18251
- Max Citation Score: 616.3701
- Similarity Product: 434.549396811533

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test