PATENT CLAIM ANALYSIS

Application Number: 16256311
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-08
Patent Classification: ["424", "135100"]

Abstract:
Methods of reducing cytokine levels and methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) are provided. Such methods include, but are not limited to, methods of treating inflammatory conditions, such as rheumatoid arthritis.

Claim (Index 70):
A method of treating a CD16+ disorder in a subject, comprising (a) determining that the level of at least one factor selected from IL-6, IL-1\u03b2, IL-8, CCL2, CCL7, CXCL5, CXCL6, MMP-7, MMP-2, and MMP-9 is elevated in the subject, and (b) administering to the subject an antibody that binds human colony stimulating factor 1 receptor (CSF1R) and blocks binding of human colony stimulating factor 1 (CSF1) to human CSF1R and blocks binding of human IL-34 to human CSF1R, and wherein the antibody comprises a heavy chain comprising a heavy chain (HC) CDR1 having the sequence of SEQ ID NO: 15, an HC CDR2 having the sequence of SEQ ID NO: 16, and an HC CDR3 having the sequence of SEQ ID NO: 17, and a light chain comprising a light chain (LC) CDR1 having the sequence of SEQ ID NO: 18, a LC CDR2 having the sequence of SEQ ID NO: 19, and a LC CDR3 having the sequence of SEQ ID NO: 20.

Metadata:
- Claim Count in Document: 117.0
- Percentile: 99.0
- Lexical Diversity: 1.27778
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15154822', '14976346', '14925534', '16243510', '15680664']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6815388115090635
- 35 USC 102 Novelty (BERT): 0.6173446513631716
- Combined Prediction Score: 0.6751193954944743
- Mean Citation Score: 392.55907400000007
- Max Citation Score: 665.8236
- Similarity Product: 463.6778397080899

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test