PATENT CLAIM ANALYSIS

Application Number: 16399991
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["703", "011000"]

Abstract:
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

Claim (Index 2):
A method for determining genetic data for DNA from cancer cells in an individual's blood sample, comprising:\n measuring cell-free DNA isolated from the blood sample that comprises the DNA from cancer cells at a plurality of at least 10 polymorphic loci, wherein the measuring comprises amplifying the at least 10 polymorphic loci from the cell-free DNA isolated from the blood sample in a single reaction volume; determining the sequence of the polymorphic loci from the DNA measurements made on the cell-free DNA isolated from the blood sample; generating a model of that accounts for different quality scores of sequence reads; generating a plurality of hypotheses of the genetic constitution of the DNA from cancer cells; and outputting the most likely genetic constitution of the DNA from cancer cells based on the relative probability of each hypothesis.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 100.0
- Lexical Diversity: 2.01316
- Patent Class: 703.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13791397', '13300235', '15917383', '16399103', '16399268']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.23339003159803
- 35 USC 102 Novelty (BERT): 0.6035406517661328
- Combined Prediction Score: 0.2704050936148403
- Mean Citation Score: 508.35367
- Max Citation Score: 571.4026
- Similarity Product: 440.17851663476233

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test