PATENT CLAIM ANALYSIS

Application Number: 15956434
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["546", "275400"]

Abstract:
The present embodiments relate to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CBP compared with BRD4.

Claim (Index 90):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, selected from:\n 5-(1-benzyl-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1,3-dimethylpyridin-2(1H)-one; 2-((4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl) methyl)benzonitrile; 3-((4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl) methyl)benzonitrile; 1-methyl-5-(1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 5-(1-(4-fluorobenzyl)-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1,4-dimethylpyridin-2(1H)-one; 4-(1-benzyl-1H-pyrazol-4-yl)-2-methylisoquinolin-1(2H)-one; 4-(1-benzyl-1H-pyrazol-4-yl)-2-methyl-2,6-naphthyridin-1(2H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-ethyl pyridin-2(1H)-one; 5-(1-(1-(3-(difluoromethyl)phenyl)ethyl)-1H-pyrazol-4-yl)-1,3-dimethylpyridin-2(1H)-one; 1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 5-(1-(cyclopropyl(phenyl)methyl)-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; (S)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; (R)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 3-(1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl) ethyl)benzonitrile; 1,3-dimethyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 5-(1-(cyclopropyl(phenyl)methyl)-1H-pyrazol-4-yl)-1,3-dimethylpyridin-2(1H)-one; 5-(1-(1-(2-chlorophenyl)ethyl)-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 1-methyl-5-(1-(1-(m-tolyl)ethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 4-fluoro-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 1-methyl-5-(1-(1-(o-tolyl)ethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 5-(1-(1-(3-chlorophenyl)ethyl)-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 1-methyl-5-(1-(1-(pyridin-3-yl)ethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 4-(1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl) ethyl) benzonitrile; 3-fluoro-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 5-(1-(1-(2-methoxyphenyl)ethyl)-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 5-(1-(1-(3-methoxyphenyl)ethyl)-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 1-methyl-5-(1-(1-(pyridin-4-yl)ethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 1,3,4-trimethyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 3-chloro-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 3-methoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 2-methyl-4-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-2,5,6,7-tetrahydro-1H-cyclopenta[c]pyridin-1-one; 1,3-dimethyl-5-(5-methyl-1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-(difluoromethyl)-4-phenyl-pyridin-2(1H)-one; 4-isopropoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 4-methoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 4-chloro-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 4-ethoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 4-(azetidin-1-yl)-1-methyl-5-(1-(1-phenyl ethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-4-(pyrrolidin-1-yl) pyridin-2(1H)-one; 1-methyl-4-(methylamino)-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 1-methyl-4-morpholino-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 1-methyl-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; (R)-4-isopropoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; (S)-4-isopropoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; (S)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-4-(pyrrolidin-1-yl) pyridin-2(1H)-one; 4-isobutoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 4-cyclobutoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 4-((1-acetylazetidin-3-yl)oxy)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 4-(cyclopentyloxy)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 4-(cyclohexyloxy)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-4-(1H-pyrazol-1-yl) pyridin-2(1H)-one; 1-methyl-4-(3-methylazetidin-1-yl)-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; (R)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-4-(pyrrolidin-1-yl) pyridin-2(1H)-one; 4-(benzyloxy)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 1-methyl-4-phenoxy-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 4-(3-methoxyazetidin-1-yl)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 4-cyclopropoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; (S)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-4-(1H-pyrazol-1-yl) pyridin-2(1H)-one; (R)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-4-(1H-pyrazol-1-yl) pyridin-2(1H)-one; 4-ethoxy-1-methyl-5-(1-(1-(p-tolyl)ethyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 5-(1-(1-([1,1\u2032-biphenyl]-4-yl)ethyl)-1H-pyrazol-4-yl)-4-ethoxy-1-methylpyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-4-ethoxy-1-methylpyridin-2(1H)-one; 4-ethoxy-1-methyl-5-(1-(4-methylbenzyl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1H-pyrazol-1-yl) pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-morpholinopyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1H-pyrrol-1-yl) pyridin-2(1H)-one; 4-ethoxy-1-methyl-5-(1H-pyrazol-4-yl)pyridin-2(1H)-one; methyl 2-((4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)methyl)benzoate; methyl 3-((4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)methyl)benzoate; (R)\u2014N-(1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)pyrrolidin-3-yl)acetamide; (S)\u2014N-(1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)pyrrolidin-3-yl)acetamide; (R)-1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)pyrrolidine-3-carboxylic acid; (S)-1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)pyrrolidine-3-carboxylic acid; 1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-1H-pyrrole-3-carboxamide; methyl 1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)-1H-pyrrole-3-carboxylate 1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-N,N-dimethyl-1H-pyrrole-3-carboxamide; 1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-1H-pyrrole-3-carboxylic acid; 1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-1H-pyrrole-3-carbonitrile; 1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-N-ethyl-1H-pyrrole-3-carboxamide; 1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-N-isopropyl-1H-pyrrole-3-carboxamide; 1-methyl-5-(1-methyl-1H-pyrazol-4-yl)-4-(1H-pyrrol-1-yl)pyridin-2(1H)-one 1-(1-methyl-5-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydropyridin-4-yl)-1H-pyrrole-3-carboxylic acid; 1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-1H-pyrrole-3-carboxamide; 1-(5-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-1H-pyrrole-3-carboxylic acid; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-pyrrolidin-1-yl-1H-pyridin-2-one; N-{2-[5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl]-cyclopentyl}-acetamide; N-{1-[5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin 4-yl]-pyrrolidin-3-ylmethyl}-acetamide; N-{1-[5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl]-pyrrolidin-3-ylmethyl}-acetamide; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(3,3,3-trifluoropropoxy) pyridin-2(1H)-one; 1-[5-(1-Benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl]-pyrrolidine-3-carboxylic acid methylamide; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(1H-imidazol-1-yl)-1-methyl-pyridin-2(1H)-one; 5-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-4-ethoxy-1-methyl-pyridin-2(1H)-one; 4-ethoxy-1-methyl-5-(1-phenyl-1H-pyrazol-4-yl)pyridin-2(1H)-one; 5-(1-(2-chlorophenyl)-1H-pyrazol-4-yl)-4-ethoxy-1-methyl-pyridin-2(1H)-one; 5-(1-(2,6-dichlorophenyl)-1H-pyrazol-4-yl)-4-ethoxy-1-methyl-pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(2-methylhydrazinyl) pyridin-2(1H)-one; 4-ethoxy-1-methyl-5-(1-{1-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-ethyl}-1H-pyrazol-4-yl)-1H-pyridin-2-one; 4-ethoxy-5-[1-(4-isopropyl-benzyl)-1H-pyrazol-4-yl]-1-methyl-1H-pyridin-2-one; 4-ethoxy-1-methyl-5-{1-[4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1H-pyrazol-4-yl}-1H-pyridin-2-one; 4-ethoxy-1-methyl-5-{1-[4-(1H-pyrazol-4-yl)-benzyl]-1H-pyrazol-4-yl}-1H-pyridin-2-one; 4-ethoxy-1-methyl-5-(1-(1-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 5-(1-(3-bromobenzyl)-1H-pyrazol-4-yl)-4-ethoxy-1-methyl-pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-o-tolyl-1H-pyridin-2-one; 1-methyl-5-(1-methyl-1H-pyrazol-4-yl)-4-phenylpyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1-methyl-1H-pyrazol-4-yl) pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1-methyl-1H-pyrazol-3-yl) pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1-methyl-1H-pyrazol-5-yl)pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(m-tolyl)pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(p-tolyl)pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(3-methoxyphenyl)-1-methyl-pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1H-pyrazol-5-yl) pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(3-methyl-1H-pyrazol-5-yl) pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(thiophen-2-yl)pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(thiophen-3-yl)pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(3-chlorophenyl)-1-methyl-pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(4-chlorophenyl)-1-methyl-pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(4-methoxyphenyl)-1-methyl-pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(isoxazol-3-yl)-1-methylpyridin-2(1H)-one; 5\u2032-(1-benzyl-1H-pyrazol-4-yl)-1\u2032-methyl-[3,4\u2032-bipyridin]-2\u2032(1\u2032H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(2-chlorophenyl)-1-methyl-pyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-[4,4\u2032-bipyridin]-2(1H)-one; 5-(1-cyclohexyl-1H-pyrazol-4-yl)-1-methyl-4-phenylpyridin-2(1H)-one; 1-methyl-4-phenyl-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl) pyridin-2(1H)-one; 1-methyl-5-(1-(1-(methyl sulfonyl)piperidin-4-yl)-1H-pyrazol-4-yl)-4-phenylpyridin-2(1H)-one; 1-methyl-4-phenyl-5-(1-phenyl-1H-pyrazol-4-yl)pyridin-2(1H)-one; 1-methyl-5-(1-((methyl sulfonyl)methyl)-1H-pyrazol-4-yl)-4-phenyl-pyridin-2(1H)-one; 1-methyl-5-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)-4-phenyl-pyridin-2(1H)-one; 5\u2032-(1-benzyl-1H-pyrazol-4-yl)-1\u2032-methyl-[2,4\u2032-bipyridin]-2\u2032(1\u2032H)-one; 5-(1-ethyl-1H-pyrazol-4-yl)-1-methyl-4-phenylpyridin-2(1H)-one; 1-methyl-4-phenyl-5-(1H-pyrazol-4-yl)pyridin-2(1H)-one; N-methyl-2-(4-(1-methyl-6-oxo-4-phenyl-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)acetamide; N,N-dimethyl-2-(4-(1-methyl-6-oxo-4-phenyl-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)acetamide; 5-(1,3-dimethyl-1H-pyrazol-4-yl)-1-methyl-4-phenylpyridin-2(1H)-one; 5-(1-isobutyl-1H-pyrazol-4-yl)-1-methyl-4-phenylpyridin-2(1H)-one; 5-(1-isopropyl-1H-pyrazol-4-yl)-1-methyl-4-phenyl pyridin-2(1H)-one; 1-methyl-4-phenyl-5-(1-propyl-1H-pyrazol-4-yl)pyridin-2(1H)-one; methyl 2-(4-(1-methyl-6-oxo-4-phenyl-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)acetate 2-(4-(1-methyl-6-oxo-4-phenyl-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)-N-propylacetamide; 4-cyclopentyl-1-methyl-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2(1H)-one; 4-cyclohexyl-1-methyl-5-(I-methyl-1H-pyrazol-4-yl)pyridin-2(1H)-one; 4-cyclopropyl-1-methyl-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2(1H)-one; 1-methyl-4-phenyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridin-2(1H)-one; 5-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-1-methyl-4-phenyl-pyridin-2(1H)-one; 5-(1-cyclopropylmethyl-1H-pyrazol-4-yl)-1-methyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one; 4-[5-(1-cyclopropylmethyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl]-N-methyl-benzamide; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(4-fluorophenyl)-1-methyl-pyridin-2(1H)-one; 4-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)benzonitrile; 4-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)benzamide; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1H-pyrazol-4-yl) pyridin-2(1H)-one; 4-(4-chloro-phenyl)-5-(1-cyclopropylmethyl-1H-pyrazol-4-yl)-1-methyl-1H-pyridin-2-one; 4-[5-(1-cyclopropylmethyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl]-benzoic acid; 4-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl) benzoic acid; 4-[5-(1-cyclopropylmethyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl]-benzonitrile; 5-(1-(cyclohexylmethyl)-1H-pyrazol-4-yl)-1-methyl-4-phenyl-pyridin-2(1H)-one; 2-(4-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)-1H-pyrazol-1-yl)acetamide; 2-(4-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)-1H-pyrazol-1-yl)acetic acid; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(1-(difluoromethyl)-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 5-(1-benzyl-1H-pyrazol-4-yl)-4-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 5-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-methyl-4-phenyl-pyridin-2(1H)-one; 2-(4-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)-1H-pyrazol-1-yl)acetonitrile; 5-(1,5-dimethyl-1H-pyrazol-4-yl)-1-methyl-4-phenylpyridin-2(1H)-one; 5-(1-Benzyl-1H-pyrazol-4-yl)-1-methyl-4-propoxy-1H-pyridin-2-one; 3-[5-(1-Benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yloxy]-propionic acid; [5-(1-Benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yloxy]-acetonitrile; 5-(1-Benzyl-1H-pyrazol-4-yl)-4-ethylsulfanyl-1-methyl-1H-pyridin-2-one; [5-(1-Benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydro-pyridin-4-ylsulfanyl]-acetic acid; 5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-((methylamino)oxy)pyridin-2(1H)-one; 5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4-yl]-4-ethoxy-1-methyl-1H-pyridin-2-one; 1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-N-methylpyrrolidine-3-sulfonamide; (R)\u2014N-(1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)pyrrolidin-3-yl)-1,1,1-trifluoromethanesulfonamide; (R)\u2014N-(1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)pyrrolidin-3-yl)methanesulfonamide; 5-(l-Benzyl-1H-pyrazol-4-yl)-4-(3-methanesulfonyl-pyrrolidin-1-yl)-1-methyl-1H-pyridin-2-one; 2-[4-(4-Ethoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-6-isopropyl-benzonitrile; 2-[4-(4-Ethoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-6-methoxy-benzonitrile; 2-Chloro-6-[4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydro-pyri din-3-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(4-Ethoxy-1-methyl-6-oxo-1,6-dihydro-pyri din-3-yl)-pyrazol-1-yl]-6-methyl-benzonitrile; 4-Ethoxy-5-[1-(2-methanesulfonyl-phenyl)-1H-pyrazol-4-yl]-1-methyl-1H-pyridin-2-one; 4-ethoxy-1-methyl-5-(1-(1-(methylsulfonyl)piperidin-3-yl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 2-[4-(4-Ethoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-4-methoxy-benzonitrile; 2-[4-(4-Ethoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-4-phenoxy-benzonitrile; 4-Cyclopropoxy-2-[4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzonitrile; 5-(1-benzyl-3-nitro-1H-pyrazol-4-yl)-4-ethoxy-1-methylpyridin-2(1H)-one; 5-(3-amino-1-benzyl-1H-pyrazol-4-yl)-4-ethoxy-1-methylpyridin-2(1H)-one; N-[1-Benzyl-4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-1H-pyrazol-3-yl]-acetamide; 5-(1-Benzyl-1H-pyrazol-4-yl)-4-(2-methoxy-phenyl)-1-methyl-1H-pyridin-2-one; 5-(1-Benzyl-1H-pyrazol-4-yl)-4-(2,6-dimethyl-phenyl)-1-methyl-1H-pyridin-2-one; 5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4-yl]-1-methyl-4-phenyl-1H-pyridin-2-one; 5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4-yl]-4-(4-methoxy-phenyl)-1-methyl-1H-pyridin-2-one; 5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4-yl]-1-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyridin-2-one; 5-(1-Benzyl-1H-pyrazol-4-yl)-1-methyl-1H,1\u2032H-[4,4\u2032]bipyridinyl-2,2\u2032-dione; 5\u2032-(1-Benzyl-1H-pyrazol-4-yl)-1\u2032-methyl-1H, 1\u2032H-[3,4\u2032]bipyridinyl-6,2\u2032-dione; 5-(1-Benzyl-1H-pyrazol-4-yl)-1,6-dimethyl-1H-pyridin-2-one; 3-Dimethylamino-1-methyl-5-[1-(1-phenyl-ethyl)-1H-pyrazol-4-yl]-1H-pyridin-2-one; 3-Cyclopropyl-1-methyl-5-[1-(1-phenyl-ethyl)-1H-pyrazol-4-yl]-1H-pyridin-2-one; 1-Benzyl-4-(1,5-dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-1H-pyrazole-3-carboxylic acid ethyl ester; 2-Benzyl-4-(1,5-dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-2H-pyrazole-3-carboxylic acid ethyl ester; 4-amino-5-(1-benzyl-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 3-((5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)amino)propanoic acid; 2-[4-(4-Isopropoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(4-Isopropoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoic acid; 2-{4-[1-Methyl-4-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzonitrile; 2-[4-(1-Methyl-6,2\u2032-dioxo-1,6,1\u2032,2\u2032-tetrahydro-[4,4\u2032]bipyridinyl-3-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(1\u2032-Methyl-6,6\u2032-dioxo-1,6,1\u2032,6\u2032-tetrahydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(4-Cyclopropyl-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzonitrile; 2-{4-[1-Methyl-4-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzoic acid; 2-[4-(1,1\u2032-Dimethyl-6,6\u2032-dioxo-1,6,1\u2032,6-tetrahydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(5,1\u2032-Dimethyl-6,6\u2032-dioxo-1,6,1\u2032,6\u2032-tetrahydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(4-Cyclopropyl-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoic acid; 2-[4-(1-Methyl-6-oxo-4-phenyl-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(1-Methyl-6-oxo-4-p-tolyl-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzonitrile; 2-{4-[4-(4-Chloro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzonitrile; 2-{4-[4-(4-Fluoro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzonitrile 2-{4-[4-(3-Chloro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzonitrile; 4-f{5-[1-(2-Cyano-phenyl)-1H-pyrazol-4-yl]-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl}-benzoic acid; 4-{5-[1-(2-Cyano-phenyl)-1H-pyrazol-4-yl]-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl}-benzamide; 4-{5-[1-(2-Cyano-phenyl)-1H-pyrazol-4-yl]-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl}-N-methyl-benzamide; 2-[4-(2\u2032-Methoxy-1-methyl-6-oxo-1,6-dihydro-[4,4\u2032]bipyridinyl-3-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(1,1\u2032-Dimethyl-6,2\u2032-dioxo-1,6,1\u2032,2\u2032-tetrahydro-[4,4\u2032]bipyidinyl-3-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(1\u2032-Cyclopropyl-1-methyl-6,2\u2032-dioxo-1,6,1\u2032,2\u2032-tetrahydro-[4,4\u2032]bipyridinyl-3-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(1-Methyl-6-oxo-4-phenyl-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoic acid; 2-[4-(1-Methyl-6-oxo-4-p-tolyl-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoic acid; 2-(4-(4-(4-chlorophenyl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzoic acid; 2-{4-[4-(4-Fluoro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzoic acid; 2-[4-(1\u2032-Methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzoic acid; 2-[4-(6-Methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzoic acid; 2-{4-[4-(4-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzoic acid; 2-[4-(6-Ethoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzoic acid; 2-[4-(6-Isopropoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzoic acid; 2-[4-(6-Isobutoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzoic acid; 2-{4-[4-(4-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzonitrile; 2-[4-(6-Ethoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(6-Isopropoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(6-Isobutoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(1\u2032-Methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-(4-(6-methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-(4-(1,1\u2032,5-trimethyl-6,6\u2032-dioxo-1,1\u2032,6,6\u2032-tetrahydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-(4-(5-fluoro-1\u2032-methyl-6,6\u2032-dioxo-1,1\u2032,6,6\u2032-tetrahydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-{4-[4-(3-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzonitrile; 2-(4-(5-methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-(4-(4-(3,4-di methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-{4-[4-(2-Methoxy-pyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzonitrile; 2-(4-(1-methyl-4-(2-(methyl amino)pyrimidin-5-yl)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-{4-[1-Methyl-6-oxo-4-(3,4,5-trimethoxy-phenyl)-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-benzonitrile; 2-[4-(4-Ethoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-4-methoxy-benzoic acid; 4-Cyclopropoxy-2-[4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoic acid; 2-(4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzoic acid; 5-(1-(2-chiorophenyl)-1H-pyrazol-4-yl)-1-methyl-4-((1-methyl-1H-pyrazol-4-yl)methoxy)pyridin-2(1H)-one; 3-(4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 4-ethoxy-5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1-methylpyridin-2(1H)-one; 4-ethoxy-1-methyl-5-(1-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 2-[4-(1,5-Di methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(1,5-Dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoic acid; 2-[4-(5-Ethyl-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(5-Ethyl-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoic acid; 2-[4-(1,5-Dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-4-phenoxy-benzonitrile; 2-[4-(1,5-Dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-4-phenoxy-benzoic acid; 4-Methoxy-2-[4-(1\u2032-methyl-6,6\u2032-dioxo-1,6,1\u2032,6\u2032-tetrahydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 4-Methoxy-2-[4-(1-methyl-6-oxo-4-phenyl-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzonitrile; 2-{4-[4-(4-Chloro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-4-methoxy-benzonitrile; 2-{4-[4-(4-Fluoro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-4-methoxy-benzonitrile; 4-Methoxy-2-[4-(6-methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-[4-(6-Ethoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-4-methoxy-benzonitrile; 4-Methoxy-2-[4-(2\u2032-methoxy-1-methyl-6-oxo-1,6-dihydro-[4,4\u2032]bipyridinyl-3-yl)-pyrazol-1-yl]-benzonitrile; 4-Methoxy-2-[4-(1-methyl-6-oxo-4-phenyl-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoic acid; 2-{4-[4-(4-Choro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-4-methoxy-benzoic acid; 2-{4-[4-(4-Fluoro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-4-methoxy-benzoic acid; 4-Methoxy-2-[4-(6-methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzoic acid; 2-[4-(6-Ethoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-4-methoxy-benzoic acid; 4-Methoxy-2-[4-(2\u2032-methoxy-1-methyl-6-oxo-1,6-dihydro-[4,4\u2032]bipyridinyl-3-yl)-pyrazol-1-yl]-benzoic acid; 2-[4-(1,1\u2032-Dimethyl-6,2\u2032-dioxo-1,6,1\u2032,2\u2032-tetrahydro-[4,4\u2032]bipyridinyl-3-yl)-pyrazol-1-yl]-6-fluoro-benzonitrile; 2-Fluoro-6-[4-(6-methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-{4-[4-(4-Chloro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-6-fluoro-benzonitrile; 2-Chloro-6-[4-(1,1\u2032-dimethyl-6,2\u2032-dioxo-1,6,1\u2032,2\u2032-tetrahydro-[4,4\u2032]bipyridinyl-3-yl)-pyrazol-1-yl]-benzonitrile; 2-Chloro-6-[4-(6-methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 2-fluoro-6-(4-(4-(3-methoxy-4-methylphenyl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(4-(3-methoxy-4-methyl phenyl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(4-(2-ethylpyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-(4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-(4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzamide; 2-(4-(1-methyl-4-(2-morpholinoethoxy)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 5-[1-(2-Methanesulfonyl-phenyl)-1H-pyrazol-4-yl]1-1,1\u2032-dimethyl-1H, 1\u2032H-[4,4\u2032]bipyridinyl-2,2\u2032-dione; 5\u2032-[1-(2-Methanesulfonyl-phenyl)-1H-pyrazol-4-yl]-6-methoxy-1\u2032-methyl-1\u2032H-[3,4\u2032]bipyridinyl-2\u2032-one; 4-(4-Chloro-phenyl)-5-[1-(2-methanesulfonyl-phenyl)-1H-pyrazol-4-yl]-1-methyl-1H-pyridin-2-one; 5\u2032-[1-(2-Methanesulfonyl-phenyl)-1H-pyrazol-4-yl]-1,1\u2032-dimethyl-1H, 1\u2032H-[3,4\u2032]bipyridinyl-6,2\u2032-dione; N-cyano-2-(4-(4-(4-fluorophenyl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzamide; N-cyano-2-(4-(1-methyl-4-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzamide; N-cyano-2-(4-(4-(4-methoxyphenyl)-1-methyl-6-oxo-, 6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzamide; 2-(4-(4-(4-chlorophenyl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)-N-cyanobenzamide; N-cyano-2-(4-(2\u2032-methoxy-1-methyl-6-oxo-1,6-dihydro-[4,4\u2032-bipyridin]-3-yl)-1H-pyrazol-1-yl)benzamide; N-cyano-2-(4-(1,1\u2032-dimethyl-2\u2032,6-dioxo-1,1\u2032,2\u2032,6-tetrahydro-[4,4\u2032-bipyridin]-3-yl)-1H-pyrazol-1-yl)benzamide; N-cyano-2-(4-(6-methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzamide; N-cyano-2-(4-(1-methyl-4-(2-(methyl amino)pyrimidin-5-yl)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzamide; N-cyano-2-(4-(6-ethoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzamide; 5-(1-(2-(1H-tetrazol-5-yl)phenyl)-1H-pyrazol-4-yl)-4-(4-chlorophenyl)-1-methylpyridin-2(1H)-one; 4-(4-Methoxy-phenyl)-1-methyl-5-{1-[2-(1H-tetrazol-5-yl)-phenyl]-1H-pyrazol-4-yl}-1H-pyridin-2-one; 4-(4-Fluoro-phenyl)-1-methyl-5-{1-[2-(1H-tetrazol-5-yl)-phenyl]-1H-pyrazol-4-yl}-1H-pyridin-2-one; 1-Methyl-4-(1-methyl-1H-pyrazol-4-yl)-5-{1-[2-(1H-tetrazol-5-yl)-phenyl]-1H-pyrazol-4-yl}-1H-pyridin-2-one; 4-Cyclopropyl-1-methyl-5-{1-[2-(1H-tetrazol-5-yl)-phenyl]-1H-pyrazol-4-yl}-1H-pyridin-2-one; N-{2-[4-(4-Cyclopropyl-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoyl}-methanesulfonamide; Ethanesulfonic acid 2-[4-(4-cyclopropyl-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-pyrazol-1-yl]-benzoylamide; N-[(dimethylamino)sulfonyl]-{2-[4-(4-cyclopropyl-1-methyl-6-oxo(3-hydropyridyl))pyrazolyl]phenyl}carboxamide; 3-(4-(1,1\u2032-dimethyl-2\u2032,6-dioxo-1,1\u2032,2\u2032,6-tetrahydro-[4,4\u2032-bipyridin]-3-yl)-1H-pyrazol-1-yl)-4-methoxybenzonitrile; 4-Methoxy-3-[4-(6-methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032]bipyridinyl-3\u2032-yl)-pyrazol-1-yl]-benzonitrile; 3-{4-[4-(4-Chloro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl]-pyrazol-1-yl}-4-methoxy-benzonitrile; 6-methoxy-1\u2032-methyl-5\u2032-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-[3,4\u2032-bipyridin]-2\u2032(1\u2032H)-one; 1-methyl-4-(2-(methylamino)pyrimidin-5-yl)-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 1,1\u2032-dimethyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-[4,4\u2032-bipyridine]-2,2\u2032(1H, 1\u2032H)-dione; 4-(2-(ethylamino)pyrimidin-5-yl)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 4-(2-((2-methoxyethyl)amino)pyrimidin-5-yl)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)pyridin-2(1H)-one; 6-(3-(dimethylamino)propoxy)-1\u2032-methyl-5\u2032-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-[3,4\u2032-bipyridin]-2\u2032(1\u2032H)-one; 5-(1-(2-chlorophenyl)-1H-pyrazol-4-yl)-1,1\u2032-dimethyl-[4,4\u2032-bipyridine]-2,2\u2032(1H, 1\u2032H)-dione; 5-(1-(2-chlorophenyl)-1H-pyrazol-4-yl)-4-(2-methoxypyrimidin-5-yl)-1-methylpyridin-2(1H)-one; 5\u2032-(1-(2-chlorophenyl)-1H-pyrazol-4-yl)-6-methoxy-1\u2032,5-dimethyl-[3,4\u2032-bipyridin]-2\u2032(1\u2032H)-one; 5-(1-(2-chlorophenyl)-1H-pyrazol-4-yl)-2\u2032-methoxy-1-methyl-[4,4\u2032-bipyridin]-2(1H)-one; 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1,1\u2032-dimethyl-[4,4\u2032-bipyridine]-2,2\u2032(1H, 1\u2032H)-dione; 5\u2032-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-6-methoxy-1\u2032-methyl-[3,4\u2032-bipyridin]-2\u2032(1\u2032H)-one; 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-4-(2-methoxypyrimidin-5-yl)-1-methylpyridin-2(1H)-one; 5-(1-(2-hydroxycyclohexyl)-1H-pyrazol-4-yl)-1-methyl-4-phenylpyridin-2(1H)-one; 2-chloro-6-[4-[4-[2-(cyclopropylamino)pyrimidin-5-yl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-(4-(4-(2-(ethylamino)pyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-(4-(4-(2-((2-methoxyethyl)amino)pyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(4-(2-(ethylamino)pyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(4-(2-((2-methoxyethyl)amino)pyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(4-(2-((cyclopropylmethyl)amino)pyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(4-(2-(dimethylamino)pyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(4-(2-(cyclopentylamino)pyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(1-methyl-6-oxo-4-(2-(pyrrolidin-1-yl)pyrimidin-5-yl)-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(4-(2-(isopropylamino)pyrimidin-5-yl)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(1-methyl-4-(2-(methylamino)pyrimidin-5-yl)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-[4-[4-[2-(ethylamino)pyrimidin-5-yl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]-6-fluoro-benzonitrile; 2-[4-[4-[2-(dimethylamino)pyrimidin-5-yl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]-6-fluoro-benzonitrile; 2-chloro-6-(4-(1-methyl-4-(2-morpholinopyrimidin-5-yl)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-fluoro-6-[4-[1-methyl-6-oxo-4-(2-pyrrolidin-1-ylpyrimidin-5-yl)-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-chloro-6-(4-(1-methyl-4-(2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(1-methyl-6-oxo-4-(2-(piperidin-1-yl)pyrimidin-5-yl)-1,6-dihydropyridin-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-[4-[4-[6-(isopropylamino)-3-pyridyl]-1-methyl-6-oxo-3-pyridyl]-pyrazol-1-yl]benzonitrile; 2-chloro-6-(4-(6-(cyclopentylamino)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(1\u2032-methyl-6-(methylamino)-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile 2-chloro-6-(4-(6-(ethylamino)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-(4-(6-(cyclopentylamino)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)-6-fluorobenzonitrile; 2-(4-(6-(ethyl amino)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)-6-fluorobenzonitrile; 2-chloro-6-{4-[6-(dimethylamino)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridine]-3\u2032-yl]-1H-pyrazol-1-yl}benzonitrile; 2-(4-{6-[(cyclopropylmethyl)amino]-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridine]-3\u2032-yl}-1H-pyrazol-1-yl)-6-fluorobenzonitrile; 2-{4-[6-(dimethylamino)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridine]-3\u2032-yl]-1H-pyrazol-1-yl}-6-fluorobenzonitrile; 2-chloro-6-(4-{6-[(cyclopropylmethyl)amino]-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridine]-3\u2032-yl}-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-[4-[1-methyl-6-oxo-4-(6-pyrrolidin-1-yl-3-pyridyl)-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-fluoro-6-[4-[1-methyl-6-oxo-4-(6-pyrrolidin-1-yl-3-pyridyl)-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-fluoro-6-(4-(6-(isopropylamino)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-[4-[4-[6-(cyclopentoxy)-3-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-(4-(6-(difluoromethoxy)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)-6-fluorobenzonitrile; 2-chloro-6-(4-(6-(difluoromethoxy)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile 2-(4-(6-(3-(dimethylamino)propoxy)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(6-(3-(dimethylamino)propoxy)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-[4-[4-[6-(cyclopropylmethoxy)-3-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-fluoro-6-[4-[4-(6-isopropoxy-3-pyridyl)-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-(4-(6-ethoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)-6-fluorobenzonitrile; 2-[4-[4-[6-(cyclopropylmethoxy)-3-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]-6-fluoro-benzonitrile; 2-[4-[4-[6-(cyclopentoxy)-3-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]-6-fluoro-benzonitrile; 2-[4-[4-[6-(cyclopropoxy)-3-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]-6-fluoro-benzonitrile; 2-chloro-6-[4-[44(6-isopropoxy-3-pyridyl)-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-chloro-6-[4-[4-[6-(cyclopropoxy)-3-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-chloro-6-(4-(6-ethoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-[4-[4-(6-cyclopropyl-3-pyridyl)-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-(4-(1\u2032,6-dimethyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)-6-fluorobenzonitrile; 2-fluoro-6-(4-(1\u2032-methyl-6\u2032-oxo-6-(trifluoromethyl)-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(1\u2032,6-dimethyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(1\u2032-methyl-6\u2032-oxo-6-(trifluoromethyl)-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-chloro-6-(4-(6-ethyl-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-(4-(6-ethyl-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)-6-fluorobenzonitrile; 2-(4-(6-ethyl-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-[4-[4-(6-cyclopropyl-3-pyridyl)-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]-6-fluoro-benzonitrile; 2-fluoro-6-[4-[4-(6-isopropyl-3-pyridyl)-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-chloro-6-[4-[4-(6-isopropyl-3-pyridyl)-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-(4-(1\u2032,6-dimethyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-(4-(6-cyclopentyl-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)-6-fluorobenzonitrile; 2-chloro-6-(4-(6-cyclopentyl-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-cyclopropyl-6-[4-[1-methyl-4-(1-methyl-2-oxo-4-pyridyl)-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-cyclopropyl-6-[4-[4-[1-(cyclopropylmethyl)-2-oxo-4-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-cyclopropyl-6-(4-(6-(3-(dimethyl amino)propoxy)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-cyclopropyl-6-(4-(6-methoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-cyclopropyl-6-(4-(6-ethoxy-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 2-cyclopropyl-6-[4-[1-methyl-6-oxo-4-(2-oxo-1-propyl-4-pyridyl)-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-cyclopropyl-6-[4-[4-(1-ethyl-2-oxo-4-pyridyl)-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-cyclopropyl-6-[4-[4-[6-(2-fluoroethoxy)-3-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-cyclopropyl-6-(4-(1\u2032-cyclopropyl-1-methyl-2\u2032,6-dioxo-1,1\u2032,2\u2032,6-tetrahydro-[4,4\u2032-bipyridin]-3-yl)-1H-pyrazol-1-yl)benzonitrile; 2-cyclopropyl-6-[4-[4-[1-(2-fluoroethyl)-2-oxo-4-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-cyclopropyl-6-[4-[4-[1-(2-hydroxyethyl)-2-oxo-4-pyridyl]-1-methyl-6-oxo-3-pyridyl]pyrazol-1-yl]benzonitrile; 2-cyclopropyl-6-(4-(6-(cyclopropylmethoxy)-1\u2032-methyl-6\u2032-oxo-1\u2032,6\u2032-dihydro-[3,4\u2032-bipyridin]-3\u2032-yl)-1H-pyrazol-1-yl)benzonitrile; 4-Ethoxy-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-3-yl)-1-methyl-1H-pyridin-2-one; 5-(5-Acetyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-3-yl)-4-ethoxy-1-methyl-1H-pyridin-2-one; 1-methyl-4-phenyl-5-(5-phenyloxazol-2-yl)pyridin-2(1H)-one; 1-methyl-5-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-4-phenyl pyridin-2(1H)-one; 1-methyl-4-phenyl-5-(2-phenyloxazol-4-yl)pyridin-2(1H)-one; or 1-methyl-4-phenyl-5-(2-phenyloxazol-5-yl)pyridin-2(1H)-one.

Metadata:
- Claim Count in Document: 43.0
- Percentile: 91.0
- Lexical Diversity: 1.4
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15488674', '14361171', '12411956', '10899458', '13825665']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8292843930661832
- 35 USC 102 Novelty (BERT): 0.542106067043555
- Combined Prediction Score: 0.8005665604639204
- Mean Citation Score: 374.99574999999993
- Max Citation Score: 403.73682
- Similarity Product: 315.6322659858298

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test