PATENT CLAIM ANALYSIS

Application Number: 15781156
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["435", "006110"]

Abstract:
The present invention relates to a RET fusion gene such as a CCDC6-RET fusion gene as a biomarker to monitor the activity of the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone or a pharmaceutically acceptable salt thereof, and especially its monoethanesulphonate salt form, when used alone or optionally in combination with further pharmaceutically active ingredients and/or further treatments. The present invention also relates to specific uses of said specific compound in the treatment of cancers.

Claim (Index 15):
The method of  claim 1 , wherein said step of determining comprises a step of\n forming a detection complex of said RET fusion gene with a reagent for detecting said RET fusion gene, said reagent being a nucleic acid capable of specific binding to said RET fusion gene; and/or wherein said step of determining comprises a step of\n forming a detection complex of said RET fusion gene product with a reagent for detecting said RET fusion gene product, wherein said RET fusion gene product is a fusion protein, and wherein said reagent is an antibody capable of specific binding to said fusion protein; \n and/or wherein said step of determining comprises a step of\n forming a detection complex of said RET fusion gene product with a reagent for detecting said RET fusion gene product, wherein said RET fusion gene product is an mRNA of the RET fusion gene, and wherein said reagent is at least one nucleic acid capable of specific binding to said mRNA of the RET fusion gene.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 94.0
- Lexical Diversity: 1.5
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12720663', '14429834', '15130486', '14187280', '15590487']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6034203313126373
- 35 USC 102 Novelty (BERT): 0.5077156481064803
- Combined Prediction Score: 0.5938498629920216
- Mean Citation Score: 217.351282
- Max Citation Score: 270.6839
- Similarity Product: 186.0049920910239

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test