PATENT CLAIM ANALYSIS

Application Number: 15945630
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-10
Patent Classification: ["424", "400000"]

Abstract:
Methods for targeted delivery of therapeutic agents to a target cell or tissue with lipid nanoparticles comprising ApoE3. In embodiments, the invention specifically relates to targeted delivery of anticancer drugs, antibiotics, antifungal drugs, and diagnostic contrast agents, and associated treatment and diagnostic methods. In embodiments, diseases/conditions treated include those associated with over-expression of LDL receptors.

Claim (Index 19):
A method for treating skin conditions associated with reduced collagen production, comprising:\n topically applying a composition comprising a therapeutically effective amount of lipid nanoparticles to an affected area on a surface of the skin, the lipid nanoparticles comprising:\n a lipid core comprised of a triglyceride component and a cholesterol ester component; \n a phospholipid layer; \n a surfactant coating layer surrounding the phospholipid layer and the lipid core; \n a human recombinant apolipoprotein (ApoE3) bonded to a surface of the nanoparticle without Polysorbate 80; and \n at least one therapeutic agent in the lipid core,\n wherein the nanoparticles diffuse from the surface of the skin across the epidermis, resulting in the therapeutic agent being intracellularly released in the dermis by LDL receptor-mediated endocytosis and stimulating fibrobplast collagen production.

Metadata:
- Claim Count in Document: 48.0
- Percentile: 91.0
- Lexical Diversity: 1.48837
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11648808', '10724833', '11802727', '11802197', '11802198']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7656986140182587
- 35 USC 102 Novelty (BERT): 0.5323152499199766
- Combined Prediction Score: 0.7423602776084305
- Mean Citation Score: 356.06647200000015
- Max Citation Score: 371.93008
- Similarity Product: 254.83963173062324

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test