PATENT CLAIM ANALYSIS

Application Number: 16183050
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-02
Patent Classification: ["424", "197110"]

Abstract:
The invention provides a conjugate of a  Neisseria meningitidis  serogroup X capsular polysaccharide and a carrier molecule. The conjugate is typically made by (a) oxidising a primary hydroxyl group in the capsular polysaccharide, to give an oxidised polysaccharide with an aldehyde group; and (b) coupling the oxidised polysaccharide to a carrier molecule via the aldehyde group, thereby giving the conjugate. The conjugate may be part of an immunogenic composition. This composition may comprise one or more further antigens, particularly capsular polysaccharides from serogroups A, W135, C and Y and conjugated forms thereof. The composition may be in an aqueous formulation. The composition is useful as a vaccine, e.g. for raising an immune response in a mammal. The invention also provides processes for making the conjugate.

Claim (Index 35):
A method of preparing a conjugate of  Neisseria meningitidis  serogroup X capsular polysaccharide and a carrier molecule selected from the group consisting of\n a. (i) oxidizing a primary hydroxyl group in the capsular polysaccharide resulting in an oxidized polysaccharide comprising an aldehyde group; and (ii) coupling the oxidized polysaccharide to a carrier protein via the aldehyde group to produce the conjugate; b. (i) reductive amination of the reducing terminus of the capsular polysaccharide resulting in a modified polysaccharide with a primary amine group bonded to the C-1 atom of the terminal subunit by a covalent bond; and\n (ii) coupling the modified polysaccharide to the carrier molecule via the primary amine group to produce the conjugate; and \n c. (i) reduction of the reducing terminus of the capsular polysaccharide resulting in a modified polysaccharide comprising two vicinal hydroxyl groups at that terminus;\n (ii) oxidative cleavage of the vicinal hydroxyl groups resulting in a further modified polysaccharide with an aldehyde group at the terminus; \n (iii) reductive amination of the aldehyde group resulting in a further modified polysaccharide with a primary amine group at the terminus; and \n (iv) coupling the further modified polysaccharide to a carrier molecule via the primary amine group to produce the conjugate.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 98.0
- Lexical Diversity: 1.84615
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14401024', '12321417', '12353409', '12321418', '12321434']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7282951136157062
- 35 USC 102 Novelty (BERT): 0.6698886756665802
- Combined Prediction Score: 0.7224544698207936
- Mean Citation Score: 494.26098200000007
- Max Citation Score: 768.3376
- Similarity Product: 614.239189987564

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test