PATENT CLAIM ANALYSIS

Application Number: 16029299
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["424", "093710"]

Abstract:
The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.

Claim (Index 1):
A method of inducing death of a target cell, comprising:\n (a) expressing a system in a lymphocyte; and (b) contacting said target cell with the lymphocyte under conditions that induce said death of the target cell, wherein the system expressed in the lymphocyte comprises: (i) a chimeric transmembrane receptor polypeptide comprising a ligand binding domain, an immune cell signaling domain, and a gene modulating polypeptide (GMP), wherein the GMP comprises an actuator moiety linked to a cleavage recognition site; and (ii) a chimeric adaptor polypeptide comprising a receptor binding moiety linked to a cleavage moiety, wherein the cleavage moiety is capable of cleaving the cleavage recognition site on the receptor when the receptor binding moiety binds the receptor polypeptide in response to binding of the ligand binding domain to a ligand; wherein, upon contacting the target cell to the lymphocyte, the ligand binding domain binds a ligand present on the target cell to (i) activate cytotoxicity of the lymphocyte, and (ii) release the actuator moiety from the GMP via cleavage by the cleavage moiety at the cleavage site, wherein the actuator moiety in turn modulates expression and/or activity of an immune regulatory protein that enhances lymphocyte cytotoxicity and/or reduces a side effect of lymphocyte activation.

Metadata:
- Claim Count in Document: 40.0
- Percentile: 95.0
- Lexical Diversity: 1.56667
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15806756', '15403058', '15583658', '15096971', '15543220']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7362257768276173
- 35 USC 102 Novelty (BERT): 0.5775933375112753
- Combined Prediction Score: 0.7203625328959831
- Mean Citation Score: 400.062444
- Max Citation Score: 511.30402
- Similarity Product: 364.3807799132848

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test