PATENT CLAIM ANALYSIS

Application Number: 15967187
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["514", "210000"]

Abstract:
Compounds having a structure of formula (I), including stereoisomers and pharmaceutically acceptable salts and solvates thereof: wherein R 1  is as defined herein. Such compounds are inhibitors of the vesicular monoamine transporter 2 (VMAT2) and have utility for treating, for example, hyperkinetic disorders. Also disclosed are compositions containing these compounds in combination with a pharmaceutically acceptable carrier or diluent, as well as methods relating to the use in a subject in need thereof.

Claim (Index 1):
A compound having structure (I): or a stereoisomer or pharmaceutically acceptable salt or solvate thereof,\n wherein:\n R 1  is a) hydrogen;\n b) \u2014P(\u2550O)(OR 3 ) 2 ; \n c) \u2014C(\u2550O)alkyl, wherein alkyl is optionally substituted with R 10  and/or R 20 ; \n d) \u2014C(\u2550O)heterocyclyl, wherein heterocyclyl is optionally substituted with R 10  and/or R 20 ; \n e) \u2014C(\u2550O)carbocyclyl, wherein carbocyclyl is optionally substituted with R 10  and/or R 20 ; \n f) \u2014C(\u2550O)N(R 3 )alkyl, wherein alkyl is optionally substituted with R 10  and/or R 20 ; \n g) \u2014C(\u2550O)N(R 3 )carbocyclyl, wherein carbocyclyl is optionally substituted with R 10  and/or R 20 ; \n h) \u2014C(\u2550O)Oalkyl, wherein alkyl is optionally substituted with R 10  and/or R 20 ; or \n i) alkyl, wherein alkyl is optionally substituted with R 10  and/or R 20 ; \n \n \n and wherein,\n each R 3  is independently hydrogen or alkyl; \n each R 10  is independently halo, haloalkyl, cyano, nitro, trimethylsilanyl, \u2014OR 30 , \u2014SR 30 , \u2014OC(O)\u2014R 30 , \u2014N(R 30 ) 2 , \u2014C(O)R 30 , \u2014C(O)OR 30 , \u2014C(O)N(R 30 ) 2 , \u2014N(R 30 )C(O)OR 31 , \u2014N(R 30 )C(O)R 31 , \u2014N(R 30 )C(\u2550NR 31 )N(R 32 ) 2 , \u2014N(R 30 )S(O) t R 31  (where t is 1 to 2), \u2014S(O) t OR 30  (where t is 1 to 2), \u2014S(O) p R 30  (where p is 0 to 2) or \u2014S(O) t N(R 30 ) 2  (where t is 1 to 2), \u2014OP(\u2550O)(OR 30 ) 2 , or when a single atom bears two R 10  groups such two R 10  groups may be taken together to form oxo; \n each R 20  is independently alkyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclalkyl, heteroaryl or heteroarylalkyl, or when a single atom bears two R 20  groups such two R 20  groups may be taken together to form cycloalkyl, wherein each of said alkyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclalkyl, heteroaryl and heteroarylalkyl groups is optionally substituted with R 10  and/or R 22 ; \n each R 22  is independently alkyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclalkyl, heteroaryl or heteroarylalkyl, wherein each of said alkyl, alkenyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclalkyl, heteroaryl and heteroarylalkyl groups is optionally substituted with R 10 ; and \n each R 30 , R 31  and R 32  is independently hydrogen or alkyl.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 91.0
- Lexical Diversity: 1.37097
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15627145', '15017480', '15116786', '11937445', '13237709']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8182157416426732
- 35 USC 102 Novelty (BERT): 0.6235905971692784
- Combined Prediction Score: 0.7987532271953337
- Mean Citation Score: 422.62164999999993
- Max Citation Score: 558.68744
- Similarity Product: 542.0198074071693

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test