PATENT CLAIM ANALYSIS

Application Number: 16024145
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "250100"]

Abstract:
The present invention generally provides methods and compositions for eliciting an immune response against  Neisseria  spp. bacteria in a subject, particularly against a  Neisseria meningitidis  serogroup B strain.

Claim (Index 53):
A composition comprising:\n isolated antigenic vesicles prepared from a  Neisseria meningitidis  ( N. meningitidis ) genetically modified to disrupt production of the endogenous GNA1870 polypeptide so that the endogenous GNA1870 is not present at detectable levels in the isolated antigenic vesicles and to overexpress at least one full length meningococcal GNA1870 polypeptide so that the isolated antigenic vesicles when administered to a mammalian subject elicit anti-meningococcal GNA1870 polypeptide antibodies, wherein the overexpressed GNA1870 polypeptide is a variant 1, a variant 2 GNA1870 polypeptide, or a variant 3 GNA1870 polypeptide heterologous to the  N. meningitidis,  wherein the isolated antigenic vesicles are outer membrane vesicles (OMVs), microvesicles (MVs), or a mixture of the OMVs and the MVs, and wherein the  N. meningitidis  is genetically modified to provide for decreased toxic activity of its lipid A relative to its parental unmodified  N. meningitidis;  and a pharmaceutically acceptable carrier.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 94.0
- Lexical Diversity: 1.14815
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15237495', '14688594', '11795739', '13279006', '09917222']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8290457214459868
- 35 USC 102 Novelty (BERT): 0.7429854493653844
- Combined Prediction Score: 0.8204396942379265
- Mean Citation Score: 799.49578
- Max Citation Score: 888.7611
- Similarity Product: 825.4283236936212

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test