PATENT CLAIM ANALYSIS

Application Number: 15903671
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "248000"]

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Claim (Index 9):
The compound of  claim 6  having Formula (IIg): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein:\n ring A is independently selected from \n R 1  is independently selected from H and C 1-4  alkyl; R 1a  is independently selected from H, F, CH 3 , and OH; R 2  is independently selected from H and OH; R 3c  is independently selected from H, CHF 2 , CD 3 , and CH 3 ; R 4  is independently selected from H and F; R 8b  is independently selected from H and F; R 8c  is independently selected from H, F, Cl, CH 3 , and OCH 3 ; R 10  is independently selected from H, CF 3 , CHF 2 , aryl, \u2014(CH 2 ) n \u2014C 3-6  cycloalkyl (optionally substituted with R 11 ), \u2014(CH 2 ) n \u2014O-4- to 10-membered heterocyclyl (optionally substituted with R 11 ), F, Cl, Br, CN, NO 2 , \u2550O, C(\u2550O)NR 12 R 12 , C(\u2550O)OR 12 , Si(C 1-4  alkyl) 3 , \u2014(CH 2 ) n \u2014OR 12 , \u2014(CH 2 ) n \u2014NR 12 R 12 , \u2014S(\u2550O) p C 1-6  alkyl, NR 12 S(\u2550O) p C 1-6  alkyl, and S(\u2550O) p NR 12 R 12 ; R 11 , at each occurrence, is independently selected from H, halogen, C 1-5  alkyl, \u2014(CH 2 ) n \u2014OH, C 3-6  cycloalkyl, and phenyl; R 12 , at each occurrence, is independently selected from H, C 1-5  alkyl, C 3-6  cycloalkyl, phenyl, and heterocyclyl, or R 12  and R 12  together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C 1-4 alkyl; and n, at each occurrence, is an integer independently selected from 0, 1, and 2.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 88.0
- Lexical Diversity: 1.27778
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14872546', '15115314', '15747867', '15205059', '15735322']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.824989663492943
- 35 USC 102 Novelty (BERT): 0.6320197042332911
- Combined Prediction Score: 0.8056926675669778
- Mean Citation Score: 526.2841340000001
- Max Citation Score: 598.2743
- Similarity Product: 533.3859275579215

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test