PATENT CLAIM ANALYSIS

Application Number: 15975854
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["548", "469000"]

Abstract:
The present application, among other things, provides compounds that are capable of inhibiting the activity of anti-apoptotic Bcl-2 family proteins, for example, myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides pharmaceutical compositions as well as methods for using provided compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein. In some embodiments, a provided compound has the structure of formula I. In some embodiments, a provided compound has the structure of formula II.

Claim (Index 1):
A compound of formula I or II: or a pharmaceutically acceptable salt thereof, wherein: L 1  is an optionally substituted bivalent C 1-6  hydrocarbon chain wherein one or more methylene units are optionally replaced with -Cy-; -Cy- is an optionally substituted bivalent ring independently selected from phenylene, 3-8 membered saturated or partially unsaturated carbocyclylene, 5-6 membered heteroarylene having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or 3-8 membered saturated or partially unsaturated heterocyclylene having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R 1  is \u2014OR, \u2014SR, \u2014S(O)R, \u2014S(O) 2 R, \u2014S(O) 2 N(R) 2 , \u2014N(R) 2 , \u2014C(O)N(R) 2 , \u2014C(O)R, \u2014NRC(O)R, \u2014NRC(O)OR, \u2014NRC(O)N(R) 2 , \u2014NRS(O) 2 R, \u2014NRS(O) 2 N(R) 2 , \u2014C(O)OH, \u2014C(O)R x , \u2014S(O) 2 OH, or \u2014S(O) 2 R y , or is selected from R x  is selected from \u2014C(O)OR, \u2014NRS(O) 2 CF 3 , \u2014NRC(O)R, \u2014NRC(O)OR, \u2014NRC(O)N(R) 2 , or \u2014NRS(O) 2 R; R y  is selected from \u2014NRC(O)CF 3 , \u2014NRC(O)R, or \u2014NRC(O)N(R) 2 ; R 2  is selected from R, halo, \u2014NH 2 , \u2014CN, \u2014NO 2 , and \u2014CF 3 ; each R is independently selected from hydrogen or an optionally substituted group selected from C 1-6  aliphatic or a ring selected from a 3-8 membered saturated or partially unsaturated carbocyclic ring, phenyl, a 8-10 membered bicyclic aryl ring, a 3-8 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; L 2  is an optionally substituted bivalent C 3-6  hydrocarbon chain wherein one or two methylene units of L 2  are optionally and independently replaced with \u2014O\u2014, \u2014S\u2014, or \u2014NR\u2032\u2014, and wherein two substituents of L 2  are optionally taken together to form an optionally substituted bivalent ring selected from 3-8 membered saturated or partially unsaturated carbocyclylene or 3-8 membered saturated or partially unsaturated heterocyclylene having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R\u2032 is independently hydrogen or optionally substituted C 1-4  alkyl; R 3  is an optionally substituted ring selected from a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur; each of R 4 , R 5 , and R 6  is independently selected from R, halo, \u2014CN, \u2014NO 2 , \u2014C(O)OR\u2032, \u2014OR\u2032, \u2014SR\u2032, \u2014C(O)N(R\u2032) 2 \u2014N(R\u2032) 2 , \u2014S(O) 2 N(R) 2 , \u2014N(R\u2032)S(O) 2 CF 3 , \u2014C(O)R\u2032, \u2014N(R\u2032)C(O)R\u2032, \u2014S(O)R\u2032, \u2014S(O) 2 R\u2032, \u2014N(R\u2032)C(O)OR\u2032, and \u2014N(R\u2032)S(O) 2 R\u2032; R 7  is hydrogen, halo, \u2014CN, \u2014NO 2 , \u2014C(O)OR, \u2014OCF 3 , \u2014OR, \u2014SR, \u2014S(O) 2 OR, \u2014P(O)(OH) 2 , \u2014C(O)N(R) 2 , \u2014N(R) 2 , \u2014S(O) 2 N(R) 2 , \u2014NRS(O) 2 CF 3 , \u2014C(O)NRS(O) 2 R, \u2014S(O) 2 NRC(O)OR, \u2014S(O) 2 NRC(O)N(R) 2 , \u2014C(O)R, \u2014C(O)NRS(O) 2 CF 3 , \u2014NRC(O)R, \u2014OC(O)R, \u2014OC(O)N(R) 2 , \u2014C(NR)N(R) 2 , \u2014NRC(NR)N(R) 2 , \u2014S(O)R, \u2014S(O) 2 R, \u2014NRC(O)OR, or \u2014NRS(O) 2 R, or an optionally substituted group selected from C 1-6  aliphatic or a ring selected from a 3-8 membered saturated or partially unsaturated carbocyclic ring, phenyl, a 3-8 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an 8-14 membered bicyclic or polycyclic saturated, partially unsaturated or aryl ring, a 7-14 membered bicyclic or polycyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-14 membered bicyclic or polycyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; and optionally one of R 4  and R 5 , R 5  and R 6 , R 6  and R 7 , R 7  and L 1 , or R 2  and L 1  is taken together with their intervening atoms to form an optionally substituted ring selected from a 3-8 membered saturated or partially unsaturated carbocyclic ring, phenyl, a 3-8 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 1.63333
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14914307', '14885181', '15129042', '14429799', '14966821']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7830307057042782
- 35 USC 102 Novelty (BERT): 0.5865725326894735
- Combined Prediction Score: 0.7633848884027977
- Mean Citation Score: 388.026742
- Max Citation Score: 480.23093
- Similarity Product: 476.9500478085447

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test