PATENT CLAIM ANALYSIS

Application Number: 16061365
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "230800"]

Abstract:
The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.

Claim (Index 4):
The compound according to  claim 3  having Formula (III): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is independently selected from H, F, Cl, Br, OR b , CN, C 1-4  alkyl, and C 3-6 cycloalkyl; \n R 1a  is independently selected from F, Cl, and C 1-2  alkyl; \n R 2  is independently selected from C 1-5  alkyl optionally substituted with halogen and C 3-6 cycloalkyl, C 2-5  alkenyl, phenyl substituted with 0-3 R e , 6-membered heteroaryl substituted with 0-3 R e , C 3-6  cycloalkyl, \u2014(CH 2 ) 1-4 OC 1-3 alkyl, and \u2014(CH 2 ) 1-3 O-cycloalkyl; \n R 3  is independently selected from\n (1) \u2014(CR 4 R 4 ) r C(\u2550O)OC 1-4  alkyl substituted with 0-5 R e , \n (2) \u2014(CR 4 R 4 ) r NR 8 R 8 , \n (3) \u2014(CR 4 R 4 ) r C(\u2550O)NR 8 R 8 , \n (4) \u2014(CR 4 R 4 ) r NR a C(\u2550O)C 1-4 alkyl substituted with 0-5 R e , \n (5) \u2014(CR 4 R 4 ) r NR a C(\u2550O)(CR 4 R 4 ) f OC 1-4 alkyl substituted with 0-5 R e , \n (6) \u2014(CR 4 R 4 ) r \u2014R 5 , \n (7) \u2014(CR 4 R 4 ) r  OR 5 , and \n (8) \u2014(CR 4 R 4 ) r NR a C(\u2550O)(CR 4 R 4 ) n R 5 ; \n \n R 4  is independently selected from H, F, Cl, NR a R a , OC 1-4  alkyl, and C 1-4  alkyl; or R 4  and R 4  together with the carbon atom to which they are both attached form C 3-6  cycloalkyl substituted with 0-5 R e ; \n R 5  is independently selected from \u2014(CH 2 ) n -aryl, \u2014(CH 2 ) n \u2014C 3-6  cycloalkyl and \u2014(CH 2 ) n -heterocycle, each substituted with 0-3 R 6 ; \n R 6  is independently selected from H, F, Cl, Br, \u2014OR b , \u2550O, \u2014(CH 2 ) n C(\u2550O)R b , \u2014(CH 2 ) n C(\u2550O)OR b , \u2014(CH 2 ) n NR a R a , CN, \u2014(CH 2 ) n C(\u2550O)NR a R a , C 1-4  alkyl substituted with 0-3 R e , (CH 2 ) n \u2014C 3-6  carbocyclyl substituted with 0-3 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-3 R e ; \n R 6a  is independently selected from H, \u2014S(O) p R c , \u2014C(\u2550O)R b , \u2014C(\u2550O)NR a R a , \u2014C(\u2550O)OR b , \u2014S(O) p NR a R a , C 1-5  alkyl substituted with 0-3 R e , (CH 2 ) n \u2014C 3-6  carbocyclyl substituted with 0-3 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-3 R e ; \n R 8  and R 8  together with the nitrogen atom to which they are both attached form a heterocyclic ring comprising carbon atoms and 0-3 additional heteroatoms selected from N, NR 6a , O, and S, and substituted with 0-5 R 6 ; \n R a , at each occurrence, is independently selected from H, C 1-6  alkyl substituted with 0-5 R e , \u2014(CH 2 ) n \u2014C 3-10 carbocyclyl substituted with 0-5 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-5 R e ; or R a  and R a  together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 R e ; \n R b , at each occurrence, is independently selected from H, C 1-6  alkyl substituted with 0-5 R e , C 2-6  alkenyl substituted with 0-5 R e , C 2-6  alkynyl substituted with 0-5 R e , \u2014(CH 2 ) n \u2014C 3-10 carbocyclyl substituted with 0-5 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-5 R e ; \n R e , at each occurrence, is independently selected from C 1-6  alkyl (optionally substituted with F and Cl), OH, OCH 3 , OCF 3 , \u2014(CH 2 ) n \u2014C 3-6  cycloalkyl, \u2014(CH 2 ) n \u2014C 4-6  heterocyclyl, \u2014(CH 2 ) n -aryl, \u2014(CH 2 ) n -heteroaryl, F, Cl, Br, CN, NO 2 , \u2550O, CO 2 H; \n r is independently selected from 1 and 2; and \n n is independently selected from zero, 1, 2, and 3.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 94.0
- Lexical Diversity: 1.19512
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16309161', '15171276', '15468230', '15767364', '16340172']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7745480502567643
- 35 USC 102 Novelty (BERT): 0.5622975476888302
- Combined Prediction Score: 0.753322999999971
- Mean Citation Score: 396.694724
- Max Citation Score: 423.19574000000006
- Similarity Product: 391.8619508762265

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test