PATENT CLAIM ANALYSIS

Application Number: 15899061
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "210180"]

Abstract:
A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.

Claim (Index 1):
A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein: R 1  represents aryl represented by E 3  and E 4  each independently represent hydrogen, and E 1  represents \u2014F and E 2  represent \u2014F, \u2014Cl, \u2014CH 3  or \u2014CF 3 , or E 1  represents \u2014Cl and E 2  represents \u2014F, \u2014Cl, \u2014CH 3  or \u2014CF 3 , or E 1  represents \u2014CH 3  and E 2  represents \u2014F, \u2014Cl, \u2014CH 3 , \u2014CF 3  or \u2014CN; R 2  represents hydrogen; R 3  represents C 2-6 alkyl substituted by one Z 1 ; Z 1  represents \u2014N(R f2 )R g2 , \u2014OR q2 , or aryl represented by R f2  represents hydrogen; R g2  and R q2  represent aryl optionally substituted by one or more substituents selected from W 6 , or heteroaryl optionally substituted by one or more substituents selected from W 6 ; each W 6  independently represents halogen, \u2014R a3 , \u2014CN, \u2014C(O)R b3 , \u2014C(O)N(R c3 )R d3 , \u2014C(O)OR e3 , \u2014N(R f3 )R g3 , \u2014N(R h3 )C(O)R i3 , \u2014N(R j3 )C(O)OR k3 , \u2014N(R l3 )C(O)N(R m3 )R n3 , \u2014N(R o3 )S(O) 2 R p3 , \u2014OR q3 , \u2014OC(O)R r3 , \u2014OS(O) 2 R s3 , \u2014S(O) m R t3 , \u2014S(O) 2 N(R u3 )R v3 , heterocycloalkyl optionally substituted by one or more substituents selected from G 1 , aryl optionally substituted by one or more substituents selected from G 2 , heteroaryl (optionally substituted by one or more substituents selected from G 2 , or \u2550O; W 7  and W 11  each represent hydrogen; W 8  and W 10  independently represent hydrogen, halogen, \u2014R a3 , \u2014CN, \u2014C(O)R b3 , \u2014C(O)N(R c3 )R d3 , \u2014C(O)OR e3 , \u2014N(R f3 )R g3 , \u2014N(R h3 )C(O)R i3 , \u2014N(R j3 )C(O)OR k3 , \u2014N(R l3 )C(O)N(R m3 )R n3 , \u2014N(R o3 )S(O) 2 R p3 , \u2014OR q3 , \u2014OC(O)R r3 , \u2014OS(O) 2 R s3 , \u2014S(O) m R t3 , \u2014S(O) 2 N(R u3 )R v3 , heterocycloalkyl optionally substituted by one or more substituents selected from G 1 , aryl optionally substituted by one or more substituents selected from G 2 , or heteroaryl optionally substituted by one or more substituents selected from G 2 ; W 9  represents halogen, \u2014R a3 , \u2014CN, \u2014C(O)R b3 , \u2014C(O)N(R c3 )R d3 , \u2014C(O)OR e3 , \u2014(R f3 )R g3 , \u2014N(R h3 )C(O)R i3 , \u2014N(R j3 )C(O)OR k3 , \u2014N(R l3 )C(O)N(R m3 )R n3 , \u2014N(R n3 )S(O) 2 R p3 , \u2014OR q3x , \u2014OC(O)R r3 , \u2014OS(O) 2 R s3 , \u2014S(O) m R t3 , \u2014S(O) 2 N(R u3 )R v3 , heterocycloalkyl optionally substituted by one or more substituents selected from G 1 , aryl optionally substituted by one or more substituents selected from G 2 , or heteroaryl optionally substituted by one or more substituents selected from G 2 ; each R a3 , R b3 , R c3 , R d3 , R e3 , R f3 , R h3 , R i3 , R j3 , R l3 , R m3 , R n3 , R o3 , R q3 , R r3 , R t3 , R u3  and R v3  independently represents hydrogen or \u2014C 1-6  alkyl optionally substituted by one or more G 3 ; or any two R c3  and R d3 , R f3  and R g3 , R m3  and R n3  and/or R u3  and R v3  are linked together to form, along with the nitrogen atom to which they are attached, a 4- to 6-membered ring, which ring optionally contains one heteroatom and which ring optionally is substituted by one or more G 2 ; each R g2 , R k3 , R p3 , and R s3  independently represent C 1-6  alkyl optionally substituted by one or more G 3 ; R q3x  represents C 2-6  alkyl optionally substituted by one or more G 3 ; each G 1  and G 2  independently represents halogen, \u2014R a4 , \u2014CN, \u2014C(O)R b4 , \u2014C(O)N(R c4 )R d4 , \u2014C(O)OR e4 , \u2014N(R f4 )R g4 , \u2014N(R h4 )C(O)R 14 , \u2014N(R j4 )C(O)OR k4 , \u2014N(R l4 )C(O)N(R m4 )R n4 , \u2014N(R o4 )S(O) 2 R p4 , \u2014OR q4 , \u2014OC(O)R r4 , \u2014OS(O) 2 R s4 , \u2014S(O) m R t4 , \u2014S(O) 2 N(R u4 )R v4 , or \u2550O; G 3  represents halogen, \u2014CN, \u2014C(O)R b4 , \u2014C(O)N(R c4 )R d4 , \u2014C(O)OR e4 , \u2014N(R f4 )R g4 , \u2014N(R h4 )C(O)R i4 , \u2014N(R j4 )C(O)OR k4 , \u2014N(R l4 )C(O)N(R m4 )R n4 , \u2014N(R o4 )S(O) 2 R p4 , \u2014OR q4 , \u2014OC(O)R r4 , \u2014OS(O) 2 R s4 , \u2014S(O) m R t4 , \u2014S(O) 2 N(R u4 )R v4 , or \u2550O; each R a4 , R b4 , R c4 , R d4 , R e4 , R f4 , R h4 , R i4 , R j4 , R l4 , R m4 , R n4 , R o4 , R q4 , R r4 , R t4 , R u4  and R v4  independently represents hydrogen or \u2014C 1-6  alkyl optionally substituted by one or more \u2014F; or any two R c4  and R d4 , R f4  and R g4 , R m4  and R n4  and/or R u4  and R v4  are linked together to form, along with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring is optionally substituted by one or more \u2014F, \u2014CH 3 , \u2014CH 2 CH 3 , \u2014CHF 2 , \u2014CF 3 , \u2014CH 2 CF 3 , or \u2550O; each R g4 , R k4 , R p4  and R s4  independently represent C 1-6  alkyl optionally substituted by one or more \u2014F; and each m independently represents 0, 1 or 2.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 88.0
- Lexical Diversity: 1.18519
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14647400', '15447818', '15315461', '15315478', '11123755']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8025725659652928
- 35 USC 102 Novelty (BERT): 0.5879759232844295
- Combined Prediction Score: 0.7811129016972065
- Mean Citation Score: 440.228286
- Max Citation Score: 523.1518
- Similarity Product: 393.89645892450807

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test