PATENT CLAIM ANALYSIS

Application Number: 15760449
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-03
Patent Classification: ["514", "001100"]

Abstract:
Provided herein are polypeptides which include tenth fibronectin type III domains ( 10 Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a  10 Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3  10 Fn3 drug conjugates are also provided.

Claim (Index 54):
The FBS-drug conjugate of  claim 34 , having a structure represented by formula (I) wherein m is 1, 2, 3 or 4, Adx is a polypeptide comprising a fibronectin based scaffold (FBS) that binds specifically to human GPC3 with a K D  or 1 \u03bcM or less, the sulfur atom that is linked to \u201cAdx\u201d is a sulfur atom of a sulfhydryl group of a cysteine of the FBS, and the FBS comprises BC, DE and FG loops wherein,\n (a) the BC, DE and FG loops comprise SEQ ID NOs: 6, 7 and 8, respectively; \n (b) at least one of the BC, DE and FG loops comprises 1, 2 or 3 amino acid substitutions relative to the respective BC, DE and FG loops of SEQ ID NOs: 6, 7 and 8; \n (c) the BC, DE and FG loops comprise SEQ ID NOs: 19, 20 and 21, respectively; \n (d) at least one of the BC, DE and FG loops comprises 1, 2 or 3 amino acid substitutions relative to the respective BC, DE and FG loops of SEQ ID NOs: 19, 20 and 22; \n (e) the BC, DE and FG loops comprise SEQ ID NOs: 32, 33 and 34, respectively; \n (f) at least one of the BC, DE and FG loops comprises 1, 2 or 3 amino acid substitutions relative to the respective BC, DE and FG loops of SEQ ID NOs: 32, 33 and 34; \n (g) the BC, DE and FG loops comprise SEQ ID NOs: 45, 46 and 47, respectively; \n (h) at least one of the BC, DE and FG loops comprises 1, 2 or 3 amino acid substitutions relative to the respective BC, DE and FG loops of SEQ ID NOs: 45, 46 and 47; \n (i) the BC, DE and FG loops comprise SEQ ID NOs: 58, 59 and 60, respectively; \n (j) at least one of the BC, DE and FG loops comprises 1, 2 or 3 amino acid substitutions relative to the respective BC, DE and FG loops of SEQ ID NOs: 58, 59 and 60; \n (k) the BC, DE and FG loops comprise SEQ ID NOs: 71, 72 and 73, respectively; \n (l) at least one of the BC, DE and FG loops comprises 1, 2 or 3 amino acid substitutions relative to the respective BC, DE and FG loops of SEQ ID NOs: 71, 72 and 73; \n (m) the BC, DE and FG loops comprise SEQ ID NOs: 84, 85 and 86, respectively; \n (n) at least one of the BC, DE and FG loops comprises 1, 2 or 3 amino acid substitutions relative to the respective BC, DE and FG loops of SEQ ID NOs: 84, 85 and 86; \n (o) the BC, DE and FG loops comprise SEQ ID NOs: 99, 100 and 101, respectively; \n (p) at least one of the BC, DE and FG loops comprises 1, 2 or 3 amino acid substitutions relative to the respective BC, DE and FG loops of SEQ ID NOs: 99, 100 and 101.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.34211
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15529260', '14481641', '14025307', '15282277', '14355155']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7246844997704904
- 35 USC 102 Novelty (BERT): 0.5313445154443789
- Combined Prediction Score: 0.7053505013378792
- Mean Citation Score: 309.929192
- Max Citation Score: 336.22153
- Similarity Product: 237.794280001043

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test