PATENT CLAIM ANALYSIS

Application Number: 15986256
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "210180"]

Abstract:
Compounds of Formula (00A) and salts thereof, wherein R 1 , R 2  R 3 , R 4  and n are defined herein, are useful as inhibitors of one or more Janus kinases. Also provided are pharmaceutical compositions that include a compound of Formula (00A) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Claim (Index 1):
A compound of Formula (00A): or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:\n R 1  is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, \u2014(C 0 -C 3 alkyl)CN, \u2014(C 0 -C 3 alkyl)OR a , \u2014(C 0 -C 3 alkyl)R a , \u2014(C 0 -C 3 alkyl)SR a , \u2014(C 0 -C 3 alkyl)NR a R b , \u2014(C 0 -C 3 alkyl)OCF 3 , \u2014(C 0 -C 3 alkyl)CF 3 , \u2014(C 0 -C 3 alkyl)NO 2 , \u2014(C 0 -C 3 alkyl)C(O)R a , \u2014(C 0 -C 3 alkyl)C(O)OR a , \u2014(C 0 -C 3 alkyl)C(O)NR a R b , \u2014(C 0 -C 3 alkyl)NR a C(O)R b , \u2014(C 0 -C 3 alkyl)S(O) 1-2 R a , \u2014(C 0 -C 3 alkyl)NR a S(O) 1-2 R b , \u2014(C 0 -C 3 alkyl)S(O) 1-2 NR a R b , \u2014(C 0 -C 3 alkyl)(5-6-membered heteroaryl) or \u2014(C 0 -C 3 alkyl)phenyl, wherein R 1  is optionally substituted by one or more groups independently selected from the group consisting of halogen, C 1 -C 3 alkyl, oxo, \u2014CF 3 , \u2014(C 0 -C 3 alkyl)OR c  and \u2014(C 0 -C 3 alkyl)NR c R d ; \n R a  is independently hydrogen, C 1 -C 6 alkyl, C 3 -C 6  cycloalkyl, 3-10 membered heterocyclyl, 5-6 membered heteroaryl, \u2014C(O)R c , \u2014C(O)OR c , \u2014C(O)NR c R d , \u2014NR c C(O)R d , \u2014S(O) 1-2 R c , \u2014NR c S(O) 1-2 R d  or \u2014S(O) 1-2 NR c R d , wherein any C 3 -C 6  cycloalkyl, 3-10 membered heterocyclyl, and 5-6 membered heteroaryl of R a  is optionally substituted with one or more groups R e ; \n R b  is independently hydrogen or C 1 -C 3 alkyl, wherein said alkyl is optionally substituted by one or more groups independently selected from the group consisting of halogen and oxo; or \n R c  and R d  are independently selected from the group consisting of hydrogen, 3-6 membered heterocyclyl, C 3 -C 6  cycloalkyl, and C 1 -C 3 alkyl, wherein any 3-6 membered heterocyclyl, C 3 -C 6  cycloalkyl, and C 1 -C 3 alkyl of R c  and R d  is optionally substituted by one or more groups independently selected from the group consisting of halogen and oxo; or R c  and R d  are taken together with the atom to which they are attached to form a 3-6-membered heterocyclyl, optionally substituted by one or more groups independently selected from the group consisting of halogen, oxo, \u2014CF 3  and C 1 -C 3 alkyl; \n each R e  is independently selected from the group consisting of oxo, OR f , NR f R g , halogen, 3-10 membered heterocyclyl, C 3 -C 6  cycloalkyl, and C 1 -C 6 alkyl, wherein any C 3 -C 6  cycloalkyl and C 1 -C 6 alkyl of R e  is optionally substituted by one or more groups independently selected from the group consisting of OR f , NR f R g , halogen, 3-10 membered heterocyclyl, oxo, and cyano, and wherein any 3-10 membered heterocyclyl of R e  is optionally substituted by one or more groups independently selected from the group consisting of halogen, oxo, cyano, \u2014CF 3 , NR h R k , 3-6 membered heterocyclyl, and C 1 -C 3 alkyl that is optionally substituted by one or more groups independently selected from the group consisting of halogen, oxo, OR f , and NR h R k ; \n R f  and R g  are each independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, 3-6 membered heterocyclyl, and C 3 -C 6  cycloalkyl, wherein any C 1 -C 6 alkyl, 3-6 membered heterocyclyl, and C 3 -C 6  cycloalkyl of R f  and R g  is optionally substituted by one or more R m ; \n each R m  is independently selected from the group consisting of halogen, cyano, oxo, C 3 -C 6 cycloalkyl, 3-6 membered heterocyclyl, hydroxy, and NR h R k , wherein any C 3 -C 6 cycloalkyl and 3-6 membered heterocyclyl of R m  is optionally substituted with one or more groups independently selected from the group consisting of halogen, oxo, cyano, and C 1 -C 3 alkyl; \n R h  and R k  are each independently selected from the group consisting of hydrogen and C 1 -C 6 alkyl that is optionally substituted by one or more groups independently selected from the group consisting of halogen, cyano, 3-6 membered heterocyclyl, and oxo; or R h  and R k  are taken together with the atom to which they are attached to form a 3-6-membered heterocyclyl that is optionally substituted by one or more groups independently selected from the group consisting of halogen, cyano, oxo, \u2014CF 3  and C 1 -C 3 alkyl that is optionally substituted by one or more groups independently selected from the group consisting of halogen and oxo; \n R 2  is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6  cycloalkyl, 3-6-membered heterocyclyl, (C 3 -C 6  cycloalkyl)C 1 -C 6 alkyl, (3-6-membered heterocyclyl)C 1 -C 6 alkyl, \u2014C(O)(C 3 -C 6  cycloalkyl), or \u2014C(O)(3-6-membered heterocyclyl), wherein R 2  is optionally substituted with one or more halo; \n n is 0, 1, or 2; \n R 3  is H or NH 2 ; \n R 4  is H or CH 3 ; and \n R 5  is H or NH 2 .

Metadata:
- Claim Count in Document: 29.0
- Percentile: 93.0
- Lexical Diversity: 1.57143
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15139164', '15984747', '14670421', '15861688', '15257926']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8379377322241346
- 35 USC 102 Novelty (BERT): 0.5522821419248068
- Combined Prediction Score: 0.8093721731942018
- Mean Citation Score: 396.211206
- Max Citation Score: 435.32587
- Similarity Product: 330.76693455061377

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test