PATENT CLAIM ANALYSIS

Application Number: 16315653
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-08
Patent Classification: ["514", "300000"]

Abstract:
Disclosed are compounds inhibiting the conversion of α-KG to D-2-HG pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat IDH associated diseases, including cancer.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt, ester, hydrate, or solvate thereof, wherein,\n Z and Q are independently selected from C and N; \n A is O, S, or NR a ; \n W is linear or branched C 1-6  alkylene; \n X is C 6-12  aryl, C 6-12  heteroaryl, 3-10 membered saturated or unsaturated cycloalkyl, 3-10 membered saturated or unsaturated heterocycloalkyl; \n Y is halo, cyano, C 1-12  alkyl, C 6-12  aryl, C 1-12  alkoxyl, C 6-12  aryloxyl, 3-10 membered saturated or unsaturated cycloalkyl, 3-10 membered saturated or unsaturated heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, \u2014C(O)OR b , \u2014C(O)NR c R d , which can be optionally mono- or independently multi-substituted by one or more of halogen, hydroxyl, cyano, C 1-12  alkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 5-10  aryl, C 1-12  alkoxy, 3-10 membered saturated or unsaturated cycloalkyl, 3-10 membered heterocycloalkyl, or 3-10 membered heteroaryl, C 5-10  aryloxyl; \n R 1  is C 1-12  alkyl, 3-10 membered saturated or unsaturated cycloalkyl, aralkyl, alkoxyalkyl, hydroxyalkyl, alkoxyaralkyl, or \u2014NR e R f ; \n R 2  is hydrogen, \u2014NR g R h , \u2014C(O)OR b , or \u2014C(O)NR c R d ; \n R a , R b , R c , R d , R e , R f , R g  and R h  are independently selected from hydrogen, C 1-12  alkyl, 3-10 membered saturated or unsaturated cycloalkyl, C 6-12  aryl, which can be optionally mono- or independently multi-substituted by halogen, hydroxyl, cyano, C 1-12  alkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 5-10  aryl, C 1-12  alkoxy, 3-10 membered saturated or unsaturated cycloalkyl, 3-10 membered heterocycloalkyl, or 3-10 membered heteroaryl, C 5-10  aryloxyl; \n optionally R c  and R d  are taken together with the nitrogen atom to which they are bound to form a 4- to 8-membered heterocyclyl optionally comprising one or more additional heteroatoms selected from N, S, and O, \n optionally R g  and R h  are taken together with the nitrogen atom to which they are bound to form a 4- to 8-membered heterocyclyl optionally comprising one or more additional heteroatoms selected from N, S, and O; \n n is 0, 1 or 2.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 99.0
- Lexical Diversity: 1.22857
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14347481', '15499824', '14037761', '14818009', '14408418']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8114991570060092
- 35 USC 102 Novelty (BERT): 0.5475077803014119
- Combined Prediction Score: 0.7851000193355494
- Mean Citation Score: 410.588458
- Max Citation Score: 423.10645
- Similarity Product: 311.8395112326831

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test