PATENT CLAIM ANALYSIS

Application Number: 16219735
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-08
Patent Classification: ["514", "080000"]

Abstract:
The present disclosure provides MAT2A inhibitor compounds that are useful as therapeutic agents for treating malignancies, and wherein the compounds conform to general formula (IA): wherein R A , R B , R C , R D , and R E  are defined herein.

Claim (Index 57):
The method according to  claim 46 , wherein the compound or a pharmaceutically acceptable salt thereof is one according to formula IB: wherein\n R C  is a C 3 -C 14 -carbocycle or a 3- to 14-membered heterocycle (wherein 1 to 4 heterocycle ring members are heteroatoms selected from N, O, and S),\n each optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, \u2014NH 2 , C 6 -C 14 -aryl, (C 6 -C 14 -aryl)-C 1 -C 6 -alkyl-, carboxy, \u2014CN, oxo, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, and \u2014NH(C 1 -C 6 -alkyl), wherein the C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, and NH(C 1 -C 6 -alkyl) are independently and optionally substituted with one or more of hydroxy, halogen, \u2014NH 2 , carboxy, \u2014CN, and oxo; \n \n R D  and R E  are independently a C 3 -C 14 -carbocycle or a 3- to 14-membered heterocycle (wherein 1 to 4 heterocycle ring members are heteroatoms selected from N, O, and S), each optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, \u2014NH 2 , C 6 -C 14 -aryl, (C 6 -C 14 -aryl)-C 1 -C 6 -alkyl-, carboxy, \u2014CN, oxo, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, and \u2014NH(C 1 -C 6 -alkyl),\n wherein the C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, and NH(C 1 -C 6 -alkyl) are independently and optionally substituted with one or more of hydroxy, halogen, \u2014NH 2 , carboxy, \u2014CN, and oxo; and \n \n R 1  is selected from the group consisting of H, C 1 -C 6 -alkyl, C 3 -C 14 -carbocycle, and 3- to 14-membered heterocycle (wherein 1 to 4 heterocycle ring members are heteroatoms selected from N, O, and S),\n each optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, \u2014NH 2 , \u2014NO 2 , \u2014CN, oxo, carboxy, \u2014C(O)OC 1 -C 6 -alkyl, (C 1 -C 6 -alkyl)OC i-C-alkyl-, \u2014C(O)NH 2 , C 1 -C 6 -alkyl, \u2014C(O)H, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)N(H)-aryl-, (C 6 -C 14 -aryl)C 1 -C 6 -alkyl-, 5- to 7-membered heteroaryl, (5- to 7-membered heteroaryl)-C 1 -C 6 -alkyl-, C 6 -C 14 -aryloxy, (C 6 -C 14 -all)(C 1 -C 6 -alkoxy)-, (5- to 7-membered heteroaryl)oxy-, and (5- to 7-membered heteroaryl)(C 1 -C 6 -alkoxy)-,\n wherein the C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)N(H)\u2014, \u2014C(O)OC 1 -C 6 -alkyl, (C 1 -C 6 -alkyl)OC 1 -C 6 -alkyl-, \u2014C(O)NH 2 , C 6 -C 14 -aryl, (C 6 -C 4 -aryl)C 1 -C 6 -alkyl-, 5- to 7-membered heteroaryl, (5- to 7-membered heteroaryl)-C 1 -C 6 -alkyl-, C 6 -C 14 -aryloxy, (C 6 -C 14 -aryl)(C 1 -C 6 -alkoxy)-, (5- to 7-membered heteroaryl)oxy-, and (5- to 7-membered heteroaryl)(C 1 -C 6 -alkoxy)-, are optionally substituted with one or more of hydroxy, halogen, \u2014NH 2 , (C 1 -C 6 -alkyl)N(H)\u2014, \u2014COOH, \u2014CN, and oxo, \n wherein each heteroaryl in R 1  has 1 to 4 heteroaryl ring members that are heteroatoms selected from N, O, and S.

Metadata:
- Claim Count in Document: 110.0
- Percentile: 98.0
- Lexical Diversity: 1.32432
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15691408', '14305393', '11487884', '12669843', '14982127']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8025638118323921
- 35 USC 102 Novelty (BERT): 0.6145347634992017
- Combined Prediction Score: 0.7837609069990731
- Mean Citation Score: 379.887276
- Max Citation Score: 539.0189
- Similarity Product: 512.5477807033659

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test