PATENT CLAIM ANALYSIS

Application Number: 15881318
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "443000"]

Abstract:
The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a cereblon, Von Hippel-Lindau ligase-binding moiety, Inhibitors of Apotosis Proteins, or mouse double-minute homolog 2 ligand, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Claim (Index 5):
The bifunctional compound of  claim 1 , wherein the VLM has a chemical structure selected from the group of: wherein:\n R 1  is H, ethyl, isopropyl, tert-butyl, sec-butyl, cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl; optionally substituted alkyl, optionally substituted hydroxyalkyl, optionally substituted heteroaryl, or haloalkyl; \n R 14a  is H, haloalkyl, optionally substituted alkyl, methyl, fluoromethyl, hydroxymethyl, ethyl, isopropyl, or cyclopropyl; \n R 15  is selected from the group consisting of H, halogen, CN, OH, NO 2 , optionally substituted heteroaryl, optionally substituted aryl, optionally substituted alkyl, optionally substituted haloalkyl, optionally substituted haloalkoxy, cycloalkyl, or cycloheteroalkyl; \n X is C, CH 2 , or C\u2550O \n R 3  is absent or an optionally substituted 5 or 6 membered heteroaryl; and \n wherein the dashed line indicates the site of attachment of at least one PTM, another ULM (ULM\u2032) or a chemical linker moiety coupling at least one PTM or a ULM\u2032 or both to the ULM.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 86.0
- Lexical Diversity: 1.88462
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14822309', '15730728', '16094102', '16346483', '14707930']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8176925395476111
- 35 USC 102 Novelty (BERT): 0.5498350463535716
- Combined Prediction Score: 0.7909067902282072
- Mean Citation Score: 301.119948
- Max Citation Score: 412.60214
- Similarity Product: 312.89147765384683

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test