PATENT CLAIM ANALYSIS

Application Number: 16105290
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["424", "093700"]

Abstract:
The invention relates to forming locus-specific (or gene-specific) pools of cells from various potential donors, where the cells that express or display HLA molecules, or other polymorphic cell surface markers, and identifying the pattern of responses across these pools, notably aggregation of cells, or their acquisition of fluorescence when exposed to a labeled secondary antibody, when exposed to sera from a potential recipient. Pools of cells from different potential donors are designed and constructed in accordance with allele partitions that are identified by amino acid sequence tags, preferably defined in terms of single or combinations of variable amino acid positions encoded by the constituent alleles in the partition.

Claim (Index 7):
A method identifying cognate antigenic determinants of antibodies in serum from an individual, to be used in identifying donors of blood, blood products, cells or organ samples for said individual, comprising:\n (i) preparing a multiplicity of pools of cells, wherein the cells for each pool are selected to represent a designated group of alleles at a genetic locus encoding an antigen of interest, such that the alleles in the group all encode the same amino acids at one or more designated variable positions of the amino acid sequence of the antigen; (ii) dispensing aliquots of serum from said individual into the pools; (iii) monitoring the degree of aggregation of cells in each pool, where a greater or lesser degree of aggregation in a pool indicates that a greater or lesser proportion of the cells in that pool share the cognate antigenic determinants of the antigens recognized by antibodies in the serum; (iv) ranking pools in order of the degree of aggregation; (v) recording the rankings as an indicator of which pools contain, and therefore which alleles encode, cognate antigenic determinants to antibodies in said serum; and (vi) selecting suitable donors for the individual from potential donors whose alleles are in the group of alleles for pools with the lesser rankings by degree of aggregation.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 96.0
- Lexical Diversity: 1.54545
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15202035', '14441187', '09869003', '14102571', '13044430']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7013883842727388
- 35 USC 102 Novelty (BERT): 0.5016266871898554
- Combined Prediction Score: 0.6814122145644504
- Mean Citation Score: 208.726578
- Max Citation Score: 259.40652
- Similarity Product: 189.8395410300136

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test