PATENT CLAIM ANALYSIS

Application Number: 15775966
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "049000"]

Abstract:
The present invention relates to Amido-Substituted Pyridotriazine Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein B, X, Y, R, R 1,  R 2  and R 10  are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Pyridotriazine Derivative, and methods of using the Amido-Substituted Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.

Claim (Index 1):
A compound having the formula: or a pharmaceutically acceptable salt or prodrug thereof, wherein:\n B is C 3 -C 7  cycloalkyl, which may be optionally substituted with one or more groups, each independently selected from R 6 ; \n X is C 1 -C 3  alkylene; \n Y is \u2014CH 2 \u2014, \u2014CH(R 6 )\u2014 or \u2014N(R 3 )\u2014; \n R is H or benzyl; \n R 1  is selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, (C 1 -C 4  alkylene)-O\u2014(C 1 -C 6  alkyl), \u2014(C 1 -C 4  alkylene)-S\u2014(C 1 -C 6  alkyl), \u2014(C 1 -C 4  alkylene)-SO 2 \u2014(C 1 -C 6  alkyl), (C 1 -C 4  alkylene)-N\u2014(C 1 -C 6  alkyl) 2 , \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 , C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, phenyl, 3 to 8-membered monocyclic heterocycloalkyl and 5 or 6-membered monocyclic heteroaryl; \n R 2  represents up to 3 optional substitutents, each independently selected from halo, C 1 -C 6  alkyl, \u2014O\u2014(C 1 -C 6  alkyl) and C 1 -C 6  haloalkyl; \n R 3  is selected from H, C 1 -C 6  alkyl, \u2014SO 2 R 4 , \u2014C(O)R 4 , \u2014(C 1 -C 6  alkylene) p -C(O)N(R 5 ) 2 , \u2014(C 2 -C 4  alkylene)-O\u2014(C 1 -C 6  alkyl), \u2014(C 2 -C 4  alkylene)-S\u2014(C 1 -C 6  alkyl), \u2014(C 2 -C 4  alkylene)-SO 2 \u2014(C 1 -C 6  alkyl), \u2014(C 2 -C 4  alkylene)-N\u2014(C 1 -C 6  alkyl) 2 , \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 , C 3 -C 7  cycloalkyl, phenyl, 4 to 8-membered monocyclic heterocycloalkyl or 6-membered monocyclic heteroaryl and 8 to 10-membered bicyclic heteroaryl; \n each occurrence of R 4  is independently selected from H, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 7  cycloalkyl, phenyl, 3 to 8-membered monocyclic heterocycloalkyl, 5 or 6-membered monocyclic heteroaryl and 8 to 10-membered bicyclic heteroaryl, wherein said C 3 -C 7  cycloalkyl group, said phenyl group, said 3 to 8-membered monocyclic heterocycloalkyl group, said 5 or 6-membered monocyclic heteroaryl group and said 8 to 10-membered bicyclic heteroaryl group may be optionally substituted with one or more groups, each independently selected from R 6 ; \n each occurrence of R 5  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, \u2014(C 1 -C 6  alkylene)-N(R 7 ) 2 , C 1 -C 6  haloalkyl, \u2014C(O)O(C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 , \u2014(C 1 -C 6  alkylene) p -R 8  and \u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkyl); \n each occurrence of R 6  is independently selected from halo, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 , \u2014N(R 20 ) 2 , 3 to 8-membered monocyclic heterocycloalkyl, 6 to 10-membered bicyclic heterocycloalkyl, \u2014O\u2014(C 1 -C 6  alkyl), \u2014O\u2014(C 6 -C 10  aryl), \u2014O\u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkyl), \u2014O\u2014(C 1 -C 6  haloalkyl), \u2014O\u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkyl), \u2014S(O) 2 (C 1 -C 6  alkyl), \u2014NHS(O) 2 -(C 1 -C 6  alkyl), \u2014S(O) 2 NH\u2014(C 1 -C 6  alkyl), \u2014OC(O)\u2014(C 1 -C 6  haloalkyl), \u2014(C 1 -C 6  alkylene) p -C(O)O\u2014(C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkylene) p -C(O)\u2014(C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkylene) p -C(O)N(R 7 ) 2 , C 1 -C 6  hydroxyalkyl, \u2014P(O)(OR 9 ) 2 , and \u2014CN; \n each occurrence of R 8  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, C 1 -C 6  haloalkyl, \u2014C(O)O(C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkylene) m -R 11 , \u2014(C 1 -C 6  alkylene) p -R 8  and \u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkyl); \n each occurrence of R 8  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, 5 or 6-membered monocyclic heteroaryl and 3 to 8-membered monocyclic heterocycloalkyl; \n each occurrence of R 9  is independently selected from H, C 1 -C 6  alkyl and \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 ; \n R 10  is selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl and (C 1 -C 4  alkylene)-O\u2014(C 1 -C 6  alkyl); \n each occurrence of R 11  is independently selected from \u2014P(O)(\u2014OR 18 ) 2 , \n each occurrence of R 12  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, phenyl or benzyl, wherein said C 1 -C 6  alkyl may be optionally substituted with a group selected from halo, \u2014OR 16 , \u2014SR 16 , guanidino, \u2014N(R 16 ) 2 , \u2014C(O)OR 16 , \u2014C(O)N(R 16 ) 2 , \u2014NHC(O)R 16 , 5- or 6-membered monocyclic heteroaryl and 9- or 10-membered bicyclic heteroaryl, and wherein said phenyl group and said benzyl group may be optionally substituted with up to 2 groups, each independently selected from C 1 -C 6  alkyl, halo and \u2014OR 16 ; each occurrence of R 13  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, phenyl or benzyl, wherein said C 1 -C 6  alkyl may be optionally substituted with a group selected from halo, \u2014OR 16 , \u2014SR 16 , guanidino, \u2014N(R 16 ) 2 , \u2014C(O)OR 16 , \u2014C(O)N(R 16 ) 2 , \u2014NHC(O)R 16 , 5- or 6-membered monocyclic heteroaryl and 9- or 10-membered bicyclic heteroaryl, and wherein said phenyl group and said benzyl group may be optionally substituted with up to 2 groups, each independently selected from C 1 -C 6  alkyl, halo and \u2014OR 16 ; each occurrence of R 14  is independently selected from H, C 1 -C 20  alkyl, C 2 -C 20  alkenyl, \u2014(C 1 -C 3  alkylene) m -(C 3 -C 7  cycloalkyl), \u2014(C 1 -C 3  alkylene) m -(C 6 -C 10  aryl) or \u2014(C 1 -C 3  alkylene) m -adamantyl, wherein said C 1 -C 20  alkyl group, said C 2 -C 20  alkenyl group, said C 6 -C 10  aryl group and said adamantyl group may be optionally substituted with up to three groups, each independently selected from halo, \u2014OR 16 , \u2014C(O)OR 16 , CN, NO 2 , C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 3 -C 7  cycloalkyl, C 6 -C 10  aryl, 5- or 6-membered monocyclic heteroaryl, 9- or 10-membered bicyclic heteroaryl, \u2014N(R 16 ) 2 , \u2014C(O)N(R 16 ) 2  SR 16 , \u2014S(O)R 16 , \u2014S(O) 2 R 16 , \u2014S(O) 2 N(R 16 ) 2,  \u2014NHC(O)R 16 , \u2014NHC(O)OR 16  and \u2014NHC(O)N(R 16 ) 2 ; R 15  is H, C 6 -C 10  aryl, 5- or 6-membered monocyclic heteroaryl or 9- or 10-membered bicyclic heteroaryl, wherein said C 6 -C 10  aryl group, said 5- or 6-membered monocyclic heteroaryl group and said 9- or 10-membered bicyclic heteroaryl group may be optionally substituted with R 17 ; each occurrence of R 16  is independently H, C 1 -C 10  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, \u2014(C 1 -C 3  alkylene) m -(C 3 -C 7  cycloalkyl), \u2014(C 1 -C 3  alkylene) m -(C 6 -C 10  aryl), \u2014(C 1 -C 3  alkylene) m -(4 to 7-membered heterocycloalkyl), \u2014(C 1 -C 3  alkylene) m -(5- or 6-membered monocyclic heteroaryl) or \u2014(C 1 -C 3  alkylene) m -(9- or 10-membered bicyclic heteroaryl), wherein said C 3 -C 7  cycloalkyl group, said C 6 -C 10  aryl group, said 4 to 7-membered heterocycloalkyl group, said -5- or 6-membered monocyclic heteroaryl group or said 9- or 10-membered bicyclic heteroaryl group may be optionally substituted with R 17 ; R 17  represents from one to five substituent groups, each independently selected from C 1 -C 6  alkyl, halo, \u2014OR 19 , \u2014SR 19 , C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, \u2014O\u2014(C 1 -C 6  haloalkyl), \u2014CN, \u2014NO 2 , \u2014N(R 19 ) 2 , \u2014C(O)OR 19 , \u2014C(O)N(R 19 ) 2  and \u2014NHC(O)R 19 ; each occurence of R 18  is independently selected from H, C 1 -C 6  alkyl, C 6 -C 10  aryl, \u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 20  alkyl), \u2014(C 1 -C 6  alkylene)-O\u2014C(0)-le, and \u2014(C 1 -C 6  alkylene)-O\u2014C(O)\u2014O\u2014R 16 ; each occurrence of R 19  is independently H, C 1 -C 10  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, \u2014(C 1 -C 3  alkylene) m -(C 3 -C 7  cycloalkyl), \u2014(C 1 -C 3  alkylene) m -(C 6 -C 10  aryl), \u2014(C 1 -C 3  alkylene) m -(4 to 7-membered heterocycloalkyl), \u2014(C 1 -C 3  alkylene) m -(5- or 6-membered monocyclic heteroaryl) or \u2014(C 1 -C 3  alkylene) m -(9- or 10-membered bicyclic heteroaryl); each occurence of R 20  is independently selected from H, C 1 -C 6  alkyl and \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 ; each occurrence of Z is independently selected from a bond, \u2014O\u2014 or \u2014N(R 9 )\u2014; each occurrence of m is independently 0 or 1; and each occurrence of p is independently 0 or 1, such that at least one occurrence of R 11  must be present in the compound of formula (I).

Metadata:
- Claim Count in Document: 38.0
- Percentile: 93.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15775871', '16061369', '15560896', '15575433', '15105376']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8087350093442861
- 35 USC 102 Novelty (BERT): 0.6015784902279916
- Combined Prediction Score: 0.7880193574326567
- Mean Citation Score: 455.284054
- Max Citation Score: 510.08292
- Similarity Product: 472.36226140837687

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test