PATENT CLAIM ANALYSIS

Application Number: 16057187
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["435", "006000"]

Abstract:
The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic compounds of Formula III, and Formula IV, and pharmaceutically acceptable salts, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds and pharmaceutical compositions for treating tumor cells and inhibiting mitosis of cancerous cells.

Claim (Index 3):
A pharmaceutical composition comprising a compound of Formula III and pharmaceutically acceptable salts thereof: R 1  is one of (a) a hydrogen, (b) an alkyl having from one to ten carbon atoms and having a straight or branched configuration, and wherein the alkyl is partially or completely saturated, or a substituted alkyl having from one to ten carbon atoms, (c) a cycloalkyl having from three to ten carbon atoms, or a substituted cycloalkyl having from three to ten carbon atoms, (d) an alkylcycloalkyl, or a substituted alkylcycloalkyl, (e) an aryl or a substituted aryl, (f) an alkylaryl, or a substituted alkylaryl (g) a heteroaryl, or a substituted heteroaryl, (h) an alkylheteroaryl, or a substituted alkylheteroaryl, (i) an aromatic or a substituted aromatic, and (j) a heteroaromatic, or a substituted heteroaromatic, and wherein each substituent of any said substituted group is the same or different and is selected from the group consisting of a straight or branched alkyl, alkenyl, or alkynyl, a cyclic or alicyclic group having from one to six carbon atoms, a heterocyclic group having from one to six carbon atoms, an alkoxy group, an aryloxy group, an alkyloxyaryloxy group, an aryl group, an amine, a halogen, a phenol, a naphthalene, a piperidine, a pyrrole, a ketone, a methylalkyl ketone, and a trifluoromethyl ketone, and wherein each of said substituents may itself be substituted, and wherein any of said substituents may be optionally attached by a CH 2  bridge, and wherein the substituent may be optionally partially or completely saturated or unsaturated when it is not represented by said halogen; R 2  is one of (a) a hydrogen (H), (b) an alkyl having from one to ten carbon atoms and having a straight or branched configuration, and wherein the alkyl is partially or completely saturated, or a substituted alkyl having from one to ten carbon atoms, (c) a cycloalkyl having from three to ten carbon atoms, or a substituted cycloalkyl having from three to ten carbon atoms, (d) an alkylcycloalkyl, or a substituted alkylcycloalkyl, (e) an aryl, or a substituted aryl, (f) an alkylaryl, or a substituted alkylaryl (g) a heteroaryl, or a substituted heteroaryl, (h) an alkylheteroaryl, or a substituted alkylheteroaryl, (i) an aromatic, or a substituted aromatic, and (j) a heteroaromatic, or a substituted heteroaromatic, and wherein each substituent of any said substituted group is the same or different and is selected from the group consisting of a straight or branched alkyl, alkenyl, or alkynyl, a cyclic or alicyclic group having from one to six carbon atoms, a heterocyclic group having from one to six carbon atoms, an alkoxy group, an aryloxy group, an alkyloxyaryloxy group, an aryl group, an amine, a halogen, a phenol, a naphthalene, a piperidine, a pyrrole, a ketone, a methylalkyl ketone, and a trifluoromethyl ketone, and wherein each of said substituents may itself be substituted, and wherein any of said substituents may be optionally attached by a CH 2  bridge, and wherein the substituent may be optionally partially or completely saturated or unsaturated when it is not represented by said halogen;\n wherein (i) and (j) may optionally be attached to Y via a CH 2  bridge; \n R 3  is one of (a) a hydrogen (H), (b) a halogen, (c) an alkyl having from one to ten carbon atoms and having a straight or a branched configuration, and wherein the alkyl is partially or completely saturated; (d) an NH 2 , (e) an NHR 7 , (f) an NR 7 R 8 , (g) an OH, (h) an OR, (i) an SH, and (j) an SR, and wherein R is one of R 2 , and wherein R 7  and R 8  may be the same or different and each is one of R 2 ; R 4  is one of (a) R 1 , (b) a halogen, (c) a mono-, di-, tri- or tetra-substituted alkyl, and (d) an alkyloxy, and wherein R 1  is H or a lower alkyl and R 2  is H or a lower alkyl then R 4  is one of (a) a NR 6 R 7 , (b) a SR 6 , (c) a OR 6 , and (d) a CHR 6 R 7 , wherein R 6  and R 7  may be the same or different and each is one of R 1  and R 2 ; R 5  is one of R 2 ; R 6  is one of R 2 ; X is one of (a) NR 4 , or (b) R 7 CR 4 ; and Y is one of (a) a nitrogen (N), (b) an oxygen (O), (c) a sulfur (S), and (d) a CR 6 , wherein R 6  is one of R 1  and R 3 , and wherein when Y is O or S then R 2  is absent or is zero.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.53704
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15453953', '14719824', '12170633', '15795801', '13151536']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6348096786361106
- 35 USC 102 Novelty (BERT): 0.5531536240067588
- Combined Prediction Score: 0.6266440731731755
- Mean Citation Score: 408.393822
- Max Citation Score: 421.8268
- Similarity Product: 340.1260577054977

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test