PATENT CLAIM ANALYSIS

Application Number: 15953492
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["544", "277000"]

Abstract:
Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Claim (Index 2):
The compound of  claim 1  wherein the compound of Formula Ib, or a pharmaceutically acceptable salt thereof, wherein: X 1  and X 2  are independently O, S or Se; Z 12 , Z 13 , Z 14 , Z 15 , Z 16 , and Z 17  are independently CH or N; L 1 , starting from the carbon alpha to X 1 , and L 2 , starting from the carbon alpha to X 2 , are independently \u2014CH 2 O\u2014P(O)R 6 \u2014O\u2014, \u2014CH 2 O\u2014P(S)R 6 \u2014O\u2014, \u2014C(Y 1 )(Y 2 )O\u2014P(O)R 6 \u2014C(Y 3 )(Y 4 )\u2014, \u2014CH 2 NHSO 2 NH\u2014, \u2014CH 2 NHC(O)NH\u2014, \u2014CH 2 NHC(S)NH\u2014, \u2014CH 2 NHC(NH)NH\u2014, \u2014CH 2 NHC(O)CH 2 \u2014, \u2014CH 2 NHSO 2 CH 2 \u2014, \u2014CH 2 CH 2 C(O)NH\u2014, \u2014CH 2 CH 2 SO 2 NH\u2014, \u2014CH 2 NH(3,4-dioxocyclobuten-1,2-diyl)NH\u2014, c is 0, 1, or 2; d, e, and f are independently 0 or 1; Y 1 , Y 2 , Y 3 , and Y 4  are independently H or F; R 6  is hydroxyl, thiol, C 1-6 alkyl, C 1-6 alkyl selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or azido groups, C 1-6 alkoxy, C 1-6 alkoxy selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or azido groups, C 3-5 alkenyl-O\u2014, C 3-5 alkynyl-O\u2014, oligo(ethylene glycol), poly(ethylene glycol), borano (\u2014BH 3 \u2212 ), or \u2014NR 7 R 8 ;\n R 7  and R 8  are independently hydrogen, C 1-6 alkyl, C 1-6 alkyl selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or azido groups, cyclic \u2014(C 1-6 alkyl)-, cyclic \u2014(C 1-6 alkyl)-selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, or di(C 1-6 alkyl)amino groups, cyclic \u2014(C 1-6 oxaalkyl)-, or cyclic \u2014(C 1-6 oxaalkyl)-selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, or di(C 1-6 alkyl)amino groups; \n R 3  and R 4  are independently hydrogen, halogen, hydroxyl, amino, C 1-6 alkyl, C 1-6 alkyl selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or azido groups, C 1-6 alkoxy, C 1-6 alkoxy selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or azido groups, C 3-5 alkenyl-O\u2014, C 3-5 alkynyl-O\u2014, oligo(ethylene glycol), poly(ethylene glycol), azido, or \u2014NR 7 R 8 ; and the compound is not a previously disclosed compound, including 2\u20323\u2032-cGAMP.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 91.0
- Lexical Diversity: 1.38095
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13974261', '09526348', '13912431', '11317907', '10550857']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7893069267531343
- 35 USC 102 Novelty (BERT): 0.5214955066702818
- Combined Prediction Score: 0.7625257847448491
- Mean Citation Score: 320.80648
- Max Citation Score: 334.80106
- Similarity Product: 248.85246630077123

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test