PATENT CLAIM ANALYSIS

Application Number: 15945664
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-04
Patent Classification: ["514", "318000"]

Abstract:
Methods of improving neurodegenerative disease with CCR3 modulating agents are provided. The methods include administering a therapeutically effective amount of the CCR3 modulating agent to the subject, with a concomitant improvement in cognition, motor, or other neurodegenerative-affected function. Cognitive and motor diseases upon which the methods of the invention can improve cognition include Alzheimer's disease, Parkinson's disease, frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, glaucoma, myotonic dystrophy, vascular dementia, progressive supranuclear palsy.

Claim (Index 5):
The method of  claim 1  wherein formula 1 is\n A is CH 2 , O or NMe; \n R 1  is selected from\n NHR 1.1  \n NHR 1.2 , \n R 1.1  is phenyl, optionally substituted with one or two residues selected from the group consisting of Me, Et, Bu, CF 3 , CH 2 CONMe 2 , CH 2 NHCONH-cyclohexyl, CN, CONR 1.1.1 R 1.1.2 , COOMe, COOEt, OMe, SO 2 Me, SO 2 CH 2 CH 2 OH, SO 2 Et, SO 2 -cyclopropyl, SO 2 -piperidinyl, SO 2 NHEt, SO 2 NMeEt, F, Cl, CO-morpholinyl, CH 2 -pyridinyl, or imidazolidinyl, piperidinyl, oxazinanyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, oxadiazolyl, thiazolyl, pyridinyl, pyrimidinyl, each optionally substituted with one or two residues selected from the group consisting of Me, NHMe, \u2550O;\n R 1.1.1  H, Me, Et, t-Bu, i-Pr, cyclopropyl, CH 2 -i-Pr, CH 2 -t-Bu, CH(CH 3 )CH 2 CH 3 , CH 2 CHF 2 , CH 2 CONMe 2 , CH 2 CO-azetindinyl, CH 2 -cyclopropyl, CH 2 -cyclobutyl, CH 2 -pyranyl, CH 2 -tetrahydrofuranyl, CH 2 -furanyl, CH 2 CH 2 OH or thiadiazolyl, optionally substituted with Me; \n R 1.1.2  H, Me, Et, SO 2 Me, SO 2 Et \n \n \u2003or R 1.1.1  and R 1.1.2  together are forming a four-, five- or six-membered carbocyclic ring, optionally containing one O, replacing a carbon atom of the ring, optionally substituted with one or two residues selected from the group consisting of CH 2 OH \n R 1.2  is selected from\n pyridinyl, pyrrolyl, pyrazolyl, isoxazolyl, thiazolyl, thiadiazolyl, optionally substituted with one or two residues selected from the group consisting of Me, Et, Pr, Bu, cyclopropyl, CH 2 COOEt, CONR 1.2.1 R 1.2.2 , COOMe, COOEt, CONH 2 , OMe, Cl, Br CO-pyrrolidinyl, CO-morpholinyl or pyrazolyl, triazolyl, tetrazolyl, isoxazolyl, oxadiazolyl, each optionally substituted Me; \n benzothiazolyl, indazolyl, dihydro-indolyl, indanyl, tetrahydro-quinolinyl, each optionally substituted with one or two residues selected from the group consisting of NMe 2 , CONHMe, \u2550O; \n 4,5-dihydro-naphtho[2,1-d]thiazole, optionally substituted with NHCOMe, \n R 1.2.1  H, Me; \n R 1.2.2  H, Me; \n \n \n R 2  is selected from CH 2 -phenyl or CH 2 -naphthyl, both optionally substituted with one or two residues selected from the group consisting of CH 3 , CF 3 , OCF 3 , F, Cl, Br, Et \n R 3  is H; \n R 4  is H.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 91.0
- Lexical Diversity: 1.55932
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12727318', '13596225', '12812940', '12402910', '12616094']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8394761370639765
- 35 USC 102 Novelty (BERT): 0.4958591612292614
- Combined Prediction Score: 0.8051144394805051
- Mean Citation Score: 280.20747400000005
- Max Citation Score: 298.24933
- Similarity Product: 292.6757640735924

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test