PATENT CLAIM ANALYSIS

Application Number: 16035771
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["424", "452000"]

Abstract:
Embodiments of the disclosure relate generally to formulations, methods, kits, and dosage forms for improved stability of an active pharmaceutical ingredient, wherein the active ingredient comprises a compound of the formula: wherein X is N, Y is H or optionally substituted C 1 -C 6  alkyl; R 4  is morpholine optionally substituted with by C 1 -C 6  alkyl; R 7  is C 1 -C 6  alkyl optionally substituted by one or more F; R 8′  is halogen; and R 6  is wherein R 10  is H, C 1 -C 6  alkyl, halogen, CN or CF 3 ; R 12  is H or halogen; R 13  is H, halogen or C 1 -C 6  alkyl; and R 17  is H, C 1 -C 6  alkyl, (C 1 -C 6  alkyl)-NH 2 ; and, pharmaceutically acceptable salts and free bases thereof, wherein the active ingredient remains in substantially amorphous form after storage of the pharmaceutical formulation for a predetermined time and conditions. In one embodiment the formulations, methods, kits and dosage forms comprising the active pharmaceutical ingredient with improved stability can be used in the treatment of a condition characterized by the dysregulation of one of both of the RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways.

Claim (Index 18):
The formulation of  claim 17 , wherein the one or more binders comprise mannitol, the one or more tableting fillers comprise microcrystalline cellulose, the one or more disintegrants comprise crospovidone, and the one or more lubricants comprise magnesium stearate.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 95.0
- Lexical Diversity: 2.41053
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15581330', '15290788', '14783903', '16073355', '13957470']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.779527237171682
- 35 USC 102 Novelty (BERT): 0.5386426963637108
- Combined Prediction Score: 0.7554387830908849
- Mean Citation Score: 334.927828
- Max Citation Score: 392.866
- Similarity Product: 223.5122816157341

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test