PATENT CLAIM ANALYSIS

Application Number: 16076479
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["424", "136100"]

Abstract:
The present invention relates to engineered cells, engineered chimaeric antigen ligands (CALs), novel uses of multi-specific binding agents for bridging cells, and methods of therapy. The invention also provides variation-matched engineered cells.

Claim (Index 93):
The method of  claim 83 , wherein the ligand is a protein ligand and wherein\n (a) the immune cell comprises a first nucleotide sequence that is an endogenous sequence that expresses an amino acid sequence that is identical to the amino acid sequence of the ligand; and/or (b) the ligand is encoded in the cell by a non-endogenous nucleotide sequence (Si) comprising a human single nucleotide polymorphism (SNP1) that encodes an amino acid residue (R1) of the ligand; the genome of the cell comprises a second nucleotide sequence (S2) comprising SNP1 and (i) encoding an amino acid sequence that is identical to the amino acid sequence of the ligand and comprises R1; or (ii) encoding an amino acid sequence that is a naturally-occurring variant of the amino acid sequence of the ligand and comprises R1; and wherein S2 is an endogenous genomic sequence of the cell and SNP1 is a non-synonymous SNP.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 96.0
- Lexical Diversity: 1.34483
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15866222', '15934770', '15105074', '15637734', '15106783']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7388998387808375
- 35 USC 102 Novelty (BERT): 0.5203237937894415
- Combined Prediction Score: 0.7170422342816979
- Mean Citation Score: 319.32395
- Max Citation Score: 322.89294
- Similarity Product: 220.5854068536329

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test