PATENT CLAIM ANALYSIS

Application Number: 16125084
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["548", "361100"]

Abstract:
Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Claim (Index 34):
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1  is selected from phenyl, pyridin-2-yl, pyridin-3-yl, pyrimidin-2-yl, pyrimidin-5-yl, pyrazolyl, oxazolyl, isoxazolyl, and isothiazolyl; wherein said phenyl, pyridin-2-yl, pyridin-3-yl, pyrimidin-2-yl, pyrimidin-5-yl, pyrazolyl, oxazolyl, isoxazolyl, and isothiazolyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 10 ; or R 1  is selected from pyridin-4-yl and pyrimidin-4-yl; wherein said pyridin-4-yl and pyrimidin-4-yl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 15 ; Cy A  is phenyl substituted with 1, 2, 3, or 4 substituents independently selected from R 20 ; R 2  is selected from H, D, OH, halo, and C 1-3  alkyl; each R 10  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, halo, D, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 OC(O)NR c1 R d1 , NR c1 R d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R d1 , S(O)R b1  S(O)NR c1 R d1 , S(O) 2 R b1 , and S(O) 2 NR c1 R d1 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, and 5-10 membered heteroaryl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 11 ; each R 11  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halo, D, CN, OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3  NR c3 S(O)R b3 , NR c3 S(O) 2 R b3 , NR c3 S(O) 2 NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , and S(O) 2 NR c3 R d3 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 12 ; each R 12  is independently selected from C 1-6  alkyl, halo, D, CN, OR a5 , SR a5 , C(O)R b5 , C(O)NR c5 R d5 , C(O)OR a5 , NR c5 R d5  NR c5 C(O)R b5 , and NR c5 C(O)OR a5 ; each R 15  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halo, D, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , and OC(O)NR c1 R d1 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 11 ; each R 20  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halo, D, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , NR c2 R d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2 , and S(O) 2 R b2 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from R 21 ; each R 21  is independently selected from halo, D, CN, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 , NR c4 C(O)R b4 , and NR c4 C(O)OR a4 ; each R a1 , R c1 , and R d1  is independently selected from H and C 1-6  alkyl; each R b1  is independently selected from C 1-6  alkyl; each R a2 , R c2 , and R d2  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, and 5-10 membered heteroaryl; each R b2  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 21 ; each R a3 , R c3 , and R d3  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 12 ; each R b3  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; each R a4 , R c4 , and R d4  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; each R b4  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; each R f4  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; each R a5 , R c5 , and R d5  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; and each R b5  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 97.0
- Lexical Diversity: 1.31429
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15698788', '15698768', '15019144', '16022031', '11961424']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7822945635777093
- 35 USC 102 Novelty (BERT): 0.5463818263323144
- Combined Prediction Score: 0.7587032898531698
- Mean Citation Score: 371.056412
- Max Citation Score: 412.8742
- Similarity Product: 301.0808625919103

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test