PATENT CLAIM ANALYSIS

Application Number: 15997171
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["623", "001140"]

Abstract:
Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.

Claim (Index 19):
An apparatus for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall comprising:\n a bioprosthetic heart valve having one or more cusps, said bioprosthetic heart valve mounted on an elastical stent for replacement of a natural diseased valve; a first coating composition coated on said stent, said one or more cusps or both, said coating composition comprising one or more therapeutic agents, wherein said coating composition when eluted inhibits stenosis, obstruction and/or calcification of the bioprosthetic heart valve when implanted by preventing the attachment of cKit positive stem cells, SCA1 cells, COP cells, and/or mesenchymal stem cells to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 94.0
- Lexical Diversity: 2.11688
- Patent Class: 623.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15601236', '12135507', '15079854', '14139367', '14797449']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7771092854155013
- 35 USC 102 Novelty (BERT): 0.6442634674788047
- Combined Prediction Score: 0.7638247036218316
- Mean Citation Score: 350.938304
- Max Citation Score: 686.9313400000002
- Similarity Product: 615.3363852985789

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test