PATENT CLAIM ANALYSIS

Application Number: 16008461
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "04400A"]

Abstract:
The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.

Claim (Index 17):
A method of treating a subject having a Serpina1 deficiency variant-associated associated disease, comprising subcutaneously administering to the subject a therapeutically effective amount of a double stranded ribonucleic acid (dsRNA) agent,\n wherein said dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region, wherein said sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of the nucleotide sequences of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, or SEQ ID NO:11, and said antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of the nucleotide sequences of SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, or SEQ ID NO:25, wherein substantially all of the nucleotides of said antisense strand comprise a modification selected from the group consisting of a 2\u2032-O-methyl modification and a 2\u2032-fluoromodification, wherein said antisense strand comprises two phosphorothioate internucleotide linkages at the 5\u2032-terminus and two phosphorothioate internucleotide linkages at the 3\u2032-terminus, wherein substantially all of the nucleotides of said sense strand comprise a modification selected from the group consisting of a 2\u2032-O-methyl modification and a 2\u2032-fluoromodification, wherein said sense strand comprises two phosphorothioate internucleotide linkages at the 5\u2032-terminus and, wherein said sense strand is conjugated to one or more GalNAc derivatives attached through a branched bivalent or trivalent linker at the 3\u2032-terminus, thereby treating the subject.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 94.0
- Lexical Diversity: 1.56667
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15399820', '14284745', '14947025', '14976261', '14699140']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8740110801913602
- 35 USC 102 Novelty (BERT): 0.6682539055571831
- Combined Prediction Score: 0.8534353627279425
- Mean Citation Score: 683.64558
- Max Citation Score: 773.87994
- Similarity Product: 628.8318347930898

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test