PATENT CLAIM ANALYSIS

Application Number: 16404441
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-08
Patent Classification: ["530", "324000"]

Abstract:
The present invention relates to the use of elafin for the treatment and/or prevention of diseases or disorders associated with an increase in troponin levels, which are non elastase dependent. The present invention in a preferred embodiment relates to a method and composition, using elafin, for protecting the heart muscle or other muscles from damage induced by abnormal blood flow and/or inflammation, which may result from, for example, a heart infarction. The present invention additionally or concomitantly relates to the use of elafin for the treatment and/or prevention of disorders or diseases which are associated with a rise in the level of troponin I and/or T.

Claim (Index 1):
A method for reducing cell damage and/or cell death leading to troponin I and/or troponin T release and/or a rise in plasma troponin I and/or troponin T which comprises the administration of a polypeptide comprising the sequence of SEQ ID NO:1 or homologues, fragments or derivatives thereof having activity of inhibiting a rise of troponin, wherein said derivatives are polypeptides of SEQ ID NO:1 which are glycosylated, PEGylated, biotinylated, cyclized and/or oxidized, wherein homologue is defined as a sequence having at least 90% sequence homology to SEQ ID NO:1, and wherein fragment is defined as a sequence which differs from SEQ ID NO:1 by lacking 1-10 amino acids at the N-or C-terminals, wherein the terminology \u201cassociated with cell damage leading to troponin I (or T) release and/or with a rise in plasma Troponin I (or T)\u201d is defined to include patients which have an elevated troponin (I or T), for all disorders involving damage to a cardiac muscle level above the 99% percentile of the normal range.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 100.0
- Lexical Diversity: 1.91667
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12350104', '10322839', '10139086', '12665859', '10945442']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6195429586342716
- 35 USC 102 Novelty (BERT): 0.4995480723764576
- Combined Prediction Score: 0.6075434700084902
- Mean Citation Score: 205.619212
- Max Citation Score: 225.04285
- Similarity Product: 144.53692293022277

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test