PATENT CLAIM ANALYSIS

Application Number: 15901361
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-11
Patent Classification: ["514", "309000"]

Abstract:
Described herein are compounds and compositions for treating glaucoma and/or reducing intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin or prostaglandin analog. Compounds described herein include those in which an isoquinoline compound is covalently linked to a prostaglandin or a prostaglandin analog, and those in which an isoquinoline compound and a prostaglandin free acid together form a salt.

Claim (Index 12):
A compound of formula (III): wherein: R 1  and R 2  are independently selected from the group consisting of hydrogen and C 1 -C 4 alkyl, or R 1  and R 2  are taken together with the nitrogen atom to which they are attached to form a ring of 3, 4, 5, 6, 7 or 8 member atoms; A is \u2014CH 2 CH(R 10 )\u2014; each R 10  is independently selected from the group consisting of alkyl, alkenyl, alkynyl, amino, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, any of which may be optionally substituted; X 1  and X 2  are independently selected from the group consisting of hydrogen, hydroxy, halogen, alkyl, amino, nitro, cyano, carbonyl, carbonylamino, alkoxy, aryloxy, sulfonyl, sulfonamido, thioalkyl, and carboxyl; PG\u2296 is a deprotonated free acid of a prostaglandin or a prostaglandin analog; and wherein the prostaglandin or a prostaglandin analog is a compound of formula (IV): or an optical isomer, diastereomer or enantiomer thereof, wherein: the dashed lines independently indicate the presence or absence of a bond: A and B are independently \u2014(CR a R b ) n \u2014, wherein each R a  and R b  is independently hydrogen or C 1 -C 6  alkyl, and n is 0, 1, 2, 3 or 4; R 1  is \u2014C(O)OR c , \u2014CONHR d , \u2014C(O)NHOH, \u2014CH 2 OH, \u2014S(O) 2 R c  or \u2014C(O)NHS(O) 2 R f ; R 2  is hydrogen or C 1 -C 6  alkyl; R 3 , R 4  and R 5  are independently selected from hydrogen and an alcohol protecting group; Y is a bond, \u2014O\u2014, \u2014S\u2014, \u2014S(O), \u2014SO 2 \u2014, \u2014C(R g ) 2 \u2014, \u2014CR h \u2550CR i \u2014, \u2014NR j \u2014, or \u2014C\u2550C\u2014; Z is hydrogen, cycloalkyl, heterocyclyl, aryl or heteroaryl; R c  is selected from hydrogen, C 1 -C 6  alkyl, C 1 -C 6  heteroalkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl; R d  and R f  are independently selected from C 1 -C 6  alkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl; R g , R h  and R i  are independently selected from hydrogen, C 1 -C 6  alkyl, alkoxy and hydroxy; and R j  is hydrogen or C 1 -C 6  alkyl.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 1.625
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14213961', '15236625', '15627238', '15142461', '11728897']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8169630825765269
- 35 USC 102 Novelty (BERT): 0.5320394424247762
- Combined Prediction Score: 0.7884707185613519
- Mean Citation Score: 332.56603399999995
- Max Citation Score: 367.16824
- Similarity Product: 240.3890228875876

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test