PATENT CLAIM ANALYSIS

Application Number: 15751163
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["546", "115000"]

Abstract:
The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases.

Claim (Index 2):
The compound of  claim 1 , wherein,\n R 4a  is H, methyl, ethyl, n-propyl, or isopropyl; R 4  is methyl, ethyl, n-propyl, isopropyl, \u2014C(R 7 )(R 7a )\u2014R 8 , 5- to 6-membered heterocyclyl or vinyl, wherein each of the methyl, ethyl, n-propyl, isopropyl and vinyl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, C 3-6  cycloalkyl and cyano; or, R 4  and R 4a , together with the nitrogen atom to which they are attached, form one of the following sub-formulae: \u2003wherein each sub-formula is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from C 1-4  alkyl, C 1-4  hydroxyalkyl, oxo (\u2550O), cyano, \u2014C(R 10 )(R 10a )\u2014C(\u2550O)\u2014N(R 12 )(R 12a ), \u2014C(\u2550O)\u2014OR 8a , C 1-4  haloalkyl and halogen; each of R 7  and R 7a  is independently H, C 1-4  alkyl, \u2014C(R 10 )(R 10a )\u2014C(\u2550O)\u2014N(R 12 )(R 12a ), \u2014C(\u2550O)\u2014OR 8a , C 2-6  heterocyclyl or C 2-6  alkenyl; or, R 7  and R 7a , together with the carbon atom to which they are attached, form a cyclopropyl, cyclopentyl, cyclobutyl, cyclohexyl, morpholinyl, piperidyl or pyrrolyl group, wherein each of the cyclopropyl, cyclopentyl, cyclobutyl, cyclohexyl, morpholinyl, piperidyl and pyrrolyl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from C 1-4  alkyl, C 1-4  hydroxyalkyl, C 1-4  haloalkyl, oxo (\u2550O), cyano, \u2014C(\u2550O)\u2014OR 8a  and halogen; R 8  is H, C 1-4  alkyl, cyano, \u2014N(R 12 )(R 12a ), \u2014C(\u2550O)\u2014C(\u2550O)\u2014N(R 12 )(R 12a ), \u2014C(\u2550O)\u2014N(R 12 )(R 12a ), \u2014C(\u2550O)\u2014OR 8a , C 3-6  heterocyclyl or C 2-6  alkenyl.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.42222
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12734224', '14647445', '14397200', '15580978', '14894817']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8213192291062112
- 35 USC 102 Novelty (BERT): 0.5303767841106087
- Combined Prediction Score: 0.792224984606651
- Mean Citation Score: 341.089354
- Max Citation Score: 366.94565
- Similarity Product: 272.33818776301143

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test