PATENT CLAIM ANALYSIS

Application Number: 15775647
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "171000"]

Abstract:
Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.

Claim (Index 11):
The compound of  claim 5 , wherein A is methylene, B is NH, m is 1, w is 2, E is a citric acid based linker, Z is NH, the compound characterized by formula (IV): or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein: i=0 or an integer from 1 to 5; j=0 or an integer from 1 to 5; G=absent, NR 4 , or O; P=absent or C(O); Q=absent, C 6 -C 10  arylene, or C 1 -C 6  alkylene; T=absent, C 1 -C 6  alkylene, C 6 -C 10  arylene, or C(O); X=absent, O, S, or NR 4 ; Y=absent or C 1 -C 6  alkylene; R 1 \u2550H or C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 6 -C 10  aryl, or 5-10 membered heteroaryl, 5-10 membered heterocyclyl, each group except H optionally substituted by one to three substituents independently selected from the group consisting of C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, halogen, oxo (\u2550O), \u2014NR a R b , \u2014NO 2 , \u2014CN, \u2014OR 3 , and \u2014SR 3 ; R 3  at each occurrence is independently H, C 1 -C 4  alkyl, or C 1 -C 4  haloalkyl; R 4  at each occurrence is independently H or C 1 -C 4  alkyl; R a  and R b  are each independently H or C 1 -C 4  alkyl; and wherein when any of groups G, P, Q, T, X, and Y is absent, its two available adjacent groups are single-bonded to each other directly.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 93.0
- Lexical Diversity: 1.39474
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13837195', '11996009', '14448998', '14670425', '14670422']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7763962951237711
- 35 USC 102 Novelty (BERT): 0.4952940275160122
- Combined Prediction Score: 0.7482860683629952
- Mean Citation Score: 234.029932
- Max Citation Score: 241.24754
- Similarity Product: 176.26154948290107

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test