PATENT CLAIM ANALYSIS

Application Number: 15752072
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "006110"]

Abstract:
The present invention relates to a method, in particular an in vitro method, for identifying B cells, comprising analyzing the methylation status of at least one CpG position in the mammalian gene region for Low density lipoprotein receptor-related protein 5 (LRP5), wherein a demethylation or lack of methylation of said gene region is indicative for a B cell, when compared to a non-B cell. The analyses according to the invention can identify B cells on an epi-genetic level and distinguish them from all other cells in complex samples, such as, for example, other blood or immune cells. The present invention furthermore provides an improved method for quantifying B cells, in particular in complex samples. The method can be performed without a step of purifying and/or enriching cells, preferably in whole blood and/or non-trypsinized tissue. Further claimed are kits and specific primers and probes for identifying methylation.

Claim (Index 3):
The method according to  claim 1 , wherein said at least one CpG position is selected from a CpG selected from the CpG positions 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, and 24 in the amplicon according to SEQ ID NO: 1.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 88.0
- Lexical Diversity: 1.75269
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14443223', '14353671', '15661432', '13636556', '14233611']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5989865465684837
- 35 USC 102 Novelty (BERT): 0.5243989613775231
- Combined Prediction Score: 0.5915277880493877
- Mean Citation Score: 272.153478
- Max Citation Score: 316.11206
- Similarity Product: 226.08050240891217

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test