PATENT CLAIM ANALYSIS

Application Number: 16303008
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["546", "290000"]

Abstract:
The present invention provides a means capable of selectively introducing a disulfide bond with respect to two free thiol groups located in a molecule of an organic compound such as a peptide, or the like, in a short time by a simple treatment and also by a chemically stable method. A nitrogen-containing compound represented by Chemical Formula 1 below or a salt thereof: The symbols shown in Chemical Formula 1 are the same as defined in the specification.

Claim (Index 1):
A nitrogen-containing compound represented by Chemical Formula 1 below or a salt thereof: wherein W, together with other ring member atoms, forms a nitrogen-containing heterocycle selected from the group consisting of a pyridine ring, a pyrazine ring, an imidazole ring, an oxazole ring, a thiazole ring, a quinoline ring, an isoquinoline ring, a quinoxaline ring, a phenanthroline ring, a pteridine ring, and an azocine ring, X is \u2014O\u2014 or \u2014NH\u2014, Y is selected from the group consisting of a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C2-C20 alkenyl group, a substituted or unsubstituted C2-C20 alkynyl group, a substituted or unsubstituted C3-C20 cycloalkyl group, a substituted or unsubstituted C3-C20 cycloalkenyl group, a substituted or unsubstituted C6-C20 aryl group, a substituted or unsubstituted C3-C20 heteroaryl group, and a monovalent group derived from a substituted or unsubstituted aliphatic heterocycle having an electron-withdrawing property, Z represents a hydrogen atom or an electron-withdrawing substituent present on the nitrogen-containing heterocycle, p, q, and r are each independently 0 or 1, s represents an integer of 0 to 10, L 0  and L 1  each independently represent a linker having a chemically stable structure, A a  and A b  are each independently a group selected from the group consisting of \u2014CH\u2550CH\u2014, \u2014C\u2261C\u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550O)\u2014O\u2014, \u2014O\u2014C(\u2550O)\u2014, \u2014O\u2014, C1-C20 oxyalkylene group, C1-C20 alkyleneoxy group, \u2014C(\u2550O)\u2014NH\u2014, \u2014NH\u2014C(\u2550O)\u2014, \u2014NH\u2014C(\u2550O)\u2014NH\u2014, hydrazine, triazole, sulfone, sulfoxide, sulfonic acid ester, sulfonamide, sulfinic acid ester, sulfinamide, piperidine, and dioxane, and R is a hydrogen atom, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C2-C20 alkenyl group, a substituted or unsubstituted C2-C20 alkynyl group, a substituted or unsubstituted C3-C20 cycloalkyl group, a substituted or unsubstituted C3-C20 cycloalkenyl group, a substituted or unsubstituted C6-C20 aryl group, a substituted or unsubstituted C3-C20 heteroaryl group, an amino group, a hydroxy group, or a polymer carrier; provided that the following compounds (A) to (H) are excluded: (A) 3-nitro-2-pyridine sulfinic acid methyl, (B) 3-nitro-2-pyridine sulfinic acid ethyl, (C) 3-nitro-2-pyridine sulfinic acid N,N-diethylaminoethyl, (D) N-(3\u2032-nitro-T-pyridinesulfenyloxy)-5-norbornene-2,3-dicarboxyimide, (E) (S)-((tert-butoxycarbonyl)amino)-3-(((3-nitropyridin-2-yl)thio)oxy)propanoic acid, (F) (2S,3R)-2-(((benzyloxy)carbonyl)amino)-3-(((3-nitropyridin-2-yl)thio)oxy)butanoic acid, (G) 4-((((3-nitropyridin-2-yl)thio)oxy)methyl)benzoic acid, and (H) (S)-2-(((3-nitropyridin-2-yl)thio)oxy)-3-phenylpropanoic acid.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 98.0
- Lexical Diversity: 1.40678
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15675251', '14680364', '15392507', '14920189', '12659581']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7965194252652521
- 35 USC 102 Novelty (BERT): 0.5129567851496353
- Combined Prediction Score: 0.7681631612536904
- Mean Citation Score: 274.351464
- Max Citation Score: 280.16086
- Similarity Product: 193.431708997302

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test