PATENT CLAIM ANALYSIS

Application Number: 15976938
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "190100"]

Abstract:
Chimeric polyvalent recombinant proteins for use as vaccines and diagnostics for Lyme disease (e.g. in canines and humans) are provided. The chimeric proteins comprise epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types and/or OspE types. The OspC types may be associated with mammalian  Borrelia  infections.

Claim (Index 6):
A method for ascertaining whether an individual has been exposed to or infected with  Borrelia , comprising the steps of\n obtaining a biological sample from said individual, exposing said biological sample to\n at least one outer surface protein C (OspC) recombinant chimeric protein comprising an amino acid sequence SEQ ID NO: 263, \n and\n at least one outer surface protein E (OspE) recombinant protein that does not bind factor H (FH) comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 269, SEQ ID NO: 270, SEQ ID NO: 272, SEQ ID NO: 273, SEQ ID NO: 274, SEQ ID NO: 275, SEQ ID NO: 278, SEQ ID NO: 279, SEQ ID NO: 280, SEQ ID NO: 282, SEQ ID NO: 283 and SEQ ID NO: 284; \n and\n determining whether antibodies in said biological sample bind to said at least one OspC recombinant chimeric protein and said at least one OspE recombinant protein that does not bind FH, wherein detection of antibody binding is indicative of prior exposure to or infection with  Borrelia.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.3617
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11564433', '13879848', '12840653', '14449721', '14299211']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8266286838013134
- 35 USC 102 Novelty (BERT): 0.5875455045660571
- Combined Prediction Score: 0.8027203658777877
- Mean Citation Score: 625.7674400000002
- Max Citation Score: 627.2048
- Similarity Product: 388.0801886066437

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test