PATENT CLAIM ANALYSIS

Application Number: 15867010
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["546", "071000"]

Abstract:
The invention provides novel compounds having the general formula: wherein R 1  to R 6 , V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.

Claim (Index 16):
A compound according to  claim 1 , selected from the group consisting of:\n Trans-10-methoxy-11-(3-methoxypropoxy)-3,3-dimethyl-7-oxo-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; Cis-10-methoxy-11-(3-methoxypropoxy)-3,3-dimethyl-7-oxo-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; Cis-10-methoxy-3,3-dimethyl-7-oxo-11-(2,2,2-trifluoroethoxy)-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; Cis-11-isobutoxy-10-methoxy-3,3-dimethyl-7-oxo-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; Cis-11-(3-hydroxy-2,2-dimethylpropoxy)-10-methoxy-3,3-dimethyl-7-oxo-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; Cis-10-methoxy-3,3-dimethyl-11-(3-morpholinopropoxy)-7-oxo-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; Cis-10-methoxy-3,3-dimethyl-11-(3-(methylsulfonyl)propoxy)-7-oxo-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; Cis-11-((6-acetamidohexyl)oxy)-10-methoxy-3,3-dimethyl-7-oxo-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; Cis-10-methoxy-3,3-dimethyl-11-((6-(methylsulfonamido)hexyl)oxy)-7-oxo-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; Cis-13-chloro-12-(3-methoxypropoxy)-2-oxo-2,5a,6,7,8,9,10,10a-octahydrocyclohepta[c]pyrido[2,1-a]isoquinoline-3-carboxylic acid; Cis-11-methoxy-12-(3-methoxypropoxy)-8-oxo-1,3,4,4a,8,13b-hexahydropyrido[2,1-a]thiopyrano[4,3-c]isoquinoline-7-carboxylic acid; Cis-10-methoxy-3,3,11-trimethyl-7-oxo-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; and, Cis-10-methoxy-3,3-dimethyl-7-oxo-11-(pyrrolidin-1-yl)-1,2,3,3a,7,12b-hexahydrocyclopenta[c]pyrido[2,1-a]isoquinoline-6-carboxylic acid; or a pharmaceutically acceptable salt, or an enantiomer, or a diastereomer thereof.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 86.0
- Lexical Diversity: 1.29032
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15866429', '15866954', '14926393', '15674810', '15639966']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8573304408132933
- 35 USC 102 Novelty (BERT): 0.5759893999345163
- Combined Prediction Score: 0.8291963367254157
- Mean Citation Score: 442.209188
- Max Citation Score: 484.67615
- Similarity Product: 439.35028339678337

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test