PATENT CLAIM ANALYSIS

Application Number: 15897549
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-11
Patent Classification: ["514", "311000"]

Abstract:
Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Claim (Index 2):
A compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein,\n R 1  is a member selected from the group consisting of C 1 -C 8  alkyl, C 3 -C 8  cycloalkyl, 4- to 7-membered heterocycloalkyl, phenyl, and 5- to 6-membered heteroaryl, wherein each R 1  is optionally substituted with from 1-3 R a ; R 2  is phenyl, which is optionally substituted with from 1-5 R b ; R 3  is a member selected from the group consisting of C 1 -C 4  alkyl, C 3 -C 4  cycloalkyl, and 4- to 7-membered heterocycloalkyl wherein each R 3  is optionally substituted with from 1-2 R c ; R 4  is H; X is a member selected from the group consisting of H and F; each R a  is independently selected from the group consisting of halo, CN, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, \u2014COR a1 , \u2014CO 2 R a1 , \u2014SO 2 R a1 , \u2014SO 2 NR a1 R a2 , and \u2014CONR a1 R a2 , wherein each R a1  and R a2  is independently selected from the group consisting of H and C 1 -C 4  alkyl or optionally R a1  and R a2  when attached to a nitrogen atom are combined to form a 4- to 6-membered ring; each R b  is independently selected from the group consisting of halo, CN, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, \u2014COR b1 , \u2014CO 2 R b1 , \u2014SO 2 R b1 , \u2014SO 2 NR b1 R b2 , CONR b1 R b2 , NR b1 R b2 , 5- to 6-membered heteroaryl, and 5- to 6-membered heterocyclyl optionally substituted with oxo, wherein each R b1  and R b2  is independently selected from the group consisting of H and C 1 -C 4  alkyl or optionally R b1  and R b2  when attached to a nitrogen atom are combined to form a 4- to 6-membered ring; and each R c  is independently selected from the group consisting of halo and C 1 -C 2  alkoxy.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 88.0
- Lexical Diversity: 1.44444
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14309381', '14883152', '14309414', '14973132', '14443072']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.817584225909463
- 35 USC 102 Novelty (BERT): 0.5671476676251564
- Combined Prediction Score: 0.7925405700810324
- Mean Citation Score: 399.26143
- Max Citation Score: 429.06885
- Similarity Product: 425.1945695421159

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test