PATENT CLAIM ANALYSIS

Application Number: 15890575
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "186100"]

Abstract:
An altered avian NDV that contains the coding sequence of avian interleukin-4 (IL-4), or a portion thereof, in the reverse orientation suppresses in-ovo IL-4 production via RNAi when administered to embryonic birds. An immunogenic composition containing this altered NDV is included in this invention. The altered avian NDV can, optionally contain a polynucleotide encoding a heterologous antigen from a heterologous avian pathogen and can produce said heterologous antigen in-ovo.

Claim (Index 23):
A method for increasing an in-ovo inoculated hatchling chick's survival rate after exposure to an avian pathogen comprising\n (i) administering to an embryonic bird in-ovo an effective dosage of said immunogenic composition of  claim 18  to produce an inoculated embryonic bird, and (ii) incubating said inoculated embryonic bird until said inoculated embryonic bird hatches to produce an in-ovo inoculated hatchling chick, wherein said altered NDV in said immunogenic composition produces in-ovo at least one antigen from said avian pathogen and anti-sense IL-4 or a fragment thereof, wherein said anti-sense IL-4 or a fragment thereof reduces IL-4 production by said inoculated embryonic bird in-ovo, and wherein said in-ovo inoculated hatchling chick produces antibodies against said avian pathogen antigen which protect said in-ovo inoculated hatching chick from said avian pathogen and increases said survival rate of said in-ovo inoculated hatching chick after exposure to said avian pathogen compared to the survival rate of a non-inoculated hatchling chick after exposure to said avian pathogen.

Metadata:
- Claim Count in Document: 36.0
- Percentile: 88.0
- Lexical Diversity: 1.45283
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15434353', '14747419', '15120237', '13689625', '12753597']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7386218327945223
- 35 USC 102 Novelty (BERT): 0.5394058730862625
- Combined Prediction Score: 0.7187002368236963
- Mean Citation Score: 361.070134
- Max Citation Score: 387.2982
- Similarity Product: 284.39713790209294

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test