PATENT CLAIM ANALYSIS

Application Number: 16046118
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["435", "325000"]

Abstract:
The present invention describes transgenic animals with human(ized) immunoglobulin loci and transgenes encoding human(ized) Igα and/or Igβ sequences. Of particular interest are animals with transgenic heavy and light chain immunoglobulin loci capable of producing a diversified human(ized) antibody repertoire that have their endogenous production of Ig and/or endogenous Igα and/or Igβ sequences suppressed. Simultaneous expression of human(ized) immunoglobulin and human(ized) Igα and/or Igβ results in normal B-cell development, affinity maturation and efficient expression of human(ized) antibodies.

Claim (Index 10):
The method according to  claim 9 , wherein the antibody fragment is fused to a heterologous amino acid sequence.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 95.0
- Lexical Diversity: 1.81481
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12972290', '15272051', '09921819', '13050792', '11498571']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6174568360165705
- 35 USC 102 Novelty (BERT): 0.5446150690384106
- Combined Prediction Score: 0.6101726593187546
- Mean Citation Score: 317.021248
- Max Citation Score: 401.74300000000005
- Similarity Product: 234.3600128371716

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test