PATENT CLAIM ANALYSIS

Application Number: 16081260
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["544", "239000"]

Abstract:
The present invention provides an agent for treating malignant tumor, comprising a compound of formula (1): wherein R 1  to R 4  are hydrogen atom, halogen, or etc., Y is optionally-substituted alkylene group or etc.

Claim (Index 9):
The compound of  claim 1  or a pharmaceutically acceptable salt thereof, which is selected from the following compounds:\n Example 1: 6-[3-bromo-5-chloro-4-(2-hydroxy-2-methylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 2: 6-[3,5-dichloro-4-(2-hydroxy-2-methylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 7: 6-[3-chloro-5-fluoro-4-(3-hydroxy-2,2-dimethylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 12: 6-[3-bromo-2-fluoro-4-(3-hydroxypropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 19: 6-[3-chloro-2-fluoro-4-(3-hydroxypropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 22: 6-[3-chloro-2-fluoro-4-(3-hydroxypropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 24: 6-[3-bromo-2-fluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 26: 6-[3-bromo-5-fluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 31: 6-[3-chloro-4-(2-hydroxy-2-methylpropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 36: 6-[3-chloro-2-fluoro-4-(2-hydroxy-2-methylpropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 40: 6-{3-chloro-4-[(2R)-2-hydroxypropoxy]-5-methylphenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 44: 6-{3-chloro-4-[(1-hydroxycyclopropyl)methoxy]-5-methylphenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 47: 6-{3-chloro-2-fluoro-4-[(1-hydroxycyclopropyl)methoxy]phenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 48: 6-[3-bromo-2-fluoro-4-(2-hydroxypropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 53: 6-[3,5-dichloro-4-(2-hydroxypropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 54: 6-[3-chloro-2-fluoro-4-(2-hydroxypropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 55: 6-[3-chloro-4-(2-hydroxypropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 57: 6-[3-bromo-5-chloro-4-(2-hydroxypropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 59: 6-[2-fluoro-4-(2-hydroxypropoxy)-3-vinylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 64: 6-[3-chloro-2-fluoro-4-(2-hydroxybutoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 69: 6-[3-bromo-5-fluoro-4-(3-hydroxy-2,2-dimethylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 72: 6-[3-chloro-4-(3-hydroxy-2,2-dimethylpropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 99: 6-[3-chloro-5-fluoro-4-(4-hydroxy-2,2-dimethylbutoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 100: 6-[3,5-dichloro-4-(4-hydroxy-2,2-dimethylbutoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 109: 6-[3,5-dichloro-4-(2,2-difluoro-3-hydroxypropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 112: 6-[3-bromo-4-(2,2-difluoro-3-hydroxypropoxy)-2-fluorophenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 113: 6-[3-chloro-4-(2,2-difluoro-3-hydroxypropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 118: (5R)-(\u2212)-6-[3-chloro-2-fluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 120: (5R)-(\u2212)-6-[4-(2,2-difluoro-3-hydroxypropoxy)-2-fluoro-3-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 124: (5R)-(\u2212)-6-[2,3-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 125: (5R)-(\u2212)-6-[3-fluoro-4-(3-hydroxy-2,2-dimethylpropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 127: (5R)-(\u2212)-6-[3-bromo-5-chloro-4-(3-hydroxy-2,2-dimethylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 131: 6-[3-chloro-2,5-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 137: 6-[3-chloro-2-fluoro-4-(3-hydroxy-2,2-dimethylpropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 140: 6-[3-chloro-2,5-difluoro-4-(3-hydroxypropoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 142: 6-[3-chloro-4-(3-hydroxy-2-methylpropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 148: 6-[3-chloro-2-fluoro-4-(2-hydroxypropoxy)-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 151: 6-{3-chloro-2-fluoro-4-[(Z)-4-hydroxy-2-butenyloxy]-5-methylphenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 155: 6-(3-chloro-4-{[(1S*,2R*)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-methylphenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 159: 6-[3-chloro-4-(2,2-difluoro-3-hydroxypropoxy)-2-fluoro-5-methylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 160: 6-[4-(2,2-difluoro-3-hydroxypropoxy)-2-fluoro-3,5-dimethylphenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 167: 6-{3-chloro-2-fluoro-4-[(1-hydroxycyclopropyl)methoxy]-5-methylphenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 168: 6-{3-bromo-2-fluoro-4-[(1-hydroxycyclopropyl)methoxy]phenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one, \n Example 170: 6-{3,5-dichloro-4-[(1-hydroxycyclopropyl)methoxy]phenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one, and \n Example 184: 6-[2-fluoro-4-(2-hydroxy-2-methylpropoxy)-3-(trifluoromethyl)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 96.0
- Lexical Diversity: 1.16216
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12739262', '13796437', '13388884', '10472412', '13800907']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7855733178387481
- 35 USC 102 Novelty (BERT): 0.5278678975068308
- Combined Prediction Score: 0.7598027758055563
- Mean Citation Score: 330.37364
- Max Citation Score: 345.36115
- Similarity Product: 296.4168364892185

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test