PATENT CLAIM ANALYSIS

Application Number: 15887488
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["530", "388240"]

Abstract:
The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein. Preferably, the antibodies or fragments comprise specific heavy and light chain variable region sequences disclosed herein. More preferably, the antibodies or fragments also comprise specific constant region sequences, such as those associated with the nG1m1,2 or Km3 allotypes. The antibodies or fragments may bind to a human histone protein, such as H2B, H3 or H4. The antibodies or fragments are of use to treat a variety of diseases that may be associated with histones, such as autoimmune disease (e.g., SLE), atherosclerosis, arthritis, rheumatoid arthritis, edema, sepsis, septic shock, hyperinflammatory disorder, infectious disease, inflammatory disease, immune dysregulatory disorder, GVHD, transplant rejection, atherosclerosis, asthma, a coagulopathy, myocardial ischemia, thrombosis, nephritis, inflammatory liver injury, acute pancreatitis, ischemia-reperfusion injury, stroke, cardiovascular disease, and burn.

Claim (Index 7):
The chimeric or humanized antibody or fragment thereof of  claim 2 , wherein the radionuclide is selected from the group consisting of  111 In,  111 At,  177 Ln,  211 Bi,  212 Bi,  213 Bi,  211 At,  62 Cu,  67 Cu,  90 Y,  125 I,  131 I,  133 I,  32 P,  33 P,  47 Sc,  111 Ag,  67 Ga,  153 Sm,  161 Tb,  152 Dy,  166 Dy,  161 Ho,  166 Ho,  186 Re,  188 Re,  189 Re,  211 Pb,  212 Pb,  223 Ra,  225 Ac,  77 As,  89 Sr,  99 Mo,  105 Rh,  149 Pm,  169 Er,  194 Ir,  58 Co,  80m Br,  99m Tc,  103m Rh,  109 Pt,  119 Sb,  125 I,  189m Os,  192 Ir,  219 Rn,  215 Po,  221 Fr,  255 Fm,  11 C,  13 N,  15 O,  75 Br,  198 Au,  199 Au,  224 Ac,  77 Br,  113m In,  95 Ru,  97 Ru,  103 Ru,  105 Ru,  107 Hg,  203 Hg,  121m Te,  125m Te,  165 Tm,  167 Tm,  168 Tm,  197 Pt,  109 Pd,  142 Pr,  143 Pr,  161 Tb,  57 Co,  58 Co,  51 Cr,  59 Fe,  75 Se,  201 Rl,  76 Br,  169 Yb and  227 Th.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 88.0
- Lexical Diversity: 1.89362
- Patent Class: 530.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14180646', '15005596', '15487747', '14620315', '14066097']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8244049431086948
- 35 USC 102 Novelty (BERT): 0.684754137592135
- Combined Prediction Score: 0.8104398625570389
- Mean Citation Score: 649.178626
- Max Citation Score: 773.3759
- Similarity Product: 675.7039808055639

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test