PATENT CLAIM ANALYSIS

Application Number: 15986033
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "430000"]

Abstract:
A composition for prevention or treatment of pulmonary fibrosis comprising chromenone derivatives represented by Formula I of the present invention or pharmaceutically acceptable salts thereof as an active ingredient, produces altered heat shock protein 27 (HSP27) dimers, thereby preventing normal HSP27 non-phosphorylated polymers from performing a chaperone function and reducing a cell protection function that chaperone originally performs. Thus the inventive composition has a remarkable inhibitory effect on pulmonary fibrosis, in particular, an irradiation-induced pulmonary fibrosis phenomenon.

Claim (Index 1):
A method for treating pulmonary fibrosis comprising administering a therapeutically effective amount of chromenone derivatives represented by Formula I or pharmaceutically acceptable salts thereof to a patient: wherein R 1  and R 2  are each independently hydrogen, or heterocyclic C 1-4  alkyl consisting of one or two heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, and one to six carbon atoms; R 3  is C 1-10  alkyl, C 3-10  cycloalkyl, C 6-14  aryl, or heteroaryl consisting of one to four heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, and one to ten carbon atoms, wherein one or more hydrogen atoms of R 3  are each independently substituted or unsubstituted with R 4 ; and R 4  is F, Br, Cl, I, OH, OMe, OEt, NH 2 , NMe 2 , CN, COOH, COMe, COOMe, CONH 2  or C 1-4  alkyl.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 93.0
- Lexical Diversity: 1.26866
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13375217', '14317602', '14729969', '12309010', '13882363']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6898306808464078
- 35 USC 102 Novelty (BERT): 0.4733679966550452
- Combined Prediction Score: 0.6681844124272716
- Mean Citation Score: 168.29004600000005
- Max Citation Score: 173.41737
- Similarity Product: 139.34506316381697

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test