PATENT CLAIM ANALYSIS

Application Number: 15868301
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["544", "296000"]

Abstract:
The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R 1 , R 2 , R 3 , X 1 , X 2 , A and Cy variable in Formula I-I all have the meaning as defined herein.

Claim (Index 2):
The compound of  claim 1 , further defined as a compound of Formula (I) or salts thereof wherein\n R 1 , R 2  and R 3  are each independently H, F, Cl, Br, I, C 1-6  alkyl or C 1-6  haloalkyl; \n X 1  is N or C\u2014R 4 , wherein R 4  is selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, I, -(L 1 ) 0-1 -C 1-6  alkyl, -(L 1 ) 0-1 -C 1-6  haloalkyl, -(L 1 ) 0-1 -C 1-6  heteroalkyl, -(L 2 ) 0-1 -C 3-8  cycloalkyl, -(L 2 ) 0-1 -3 to 7 membered heterocycloalkyl, -(L 2 ) 0-1 -6-10 membered aryl, -(L 2 ) 0-1 -5-10 membered heteroaryl, wherein L 1  is selected from the group consisting of \u2014O\u2014, \u2014N(H)\u2014, \u2014S\u2014, \u2014N(C 1-6  alkyl)-, \u2550O, and L 2  is selected from the group consisting of \u2014O\u2014, \u2014N(H)\u2014, \u2014N(C 1-6  alkyl)-, \u2014S\u2014, \u2550O, C 1-4  alkylene, C 1-4  alkenylene, C 1-4  alkynylene, C 1-4  alkoxylene, C 1-4  aminoalkylene, C 1-4  thioalkylene and C 1-4  heteroalkylene, and wherein R 4  is optionally substituted on carbon atoms and heteroatoms with R R4  substituents selected from the group consisting of F, Cl, Br, I, C 1-6  alkyl, C 1-6  haloalkyl, 3-5 membered cycloalkyl, 3-5 membered heterocycloalkyl, C 1-6  alkoxy, C 1-6  alkylamino, C 1-6  dialkylamino, C 1-6  alkylthio, \u2550O, \u2014NH 2 , \u2014CN, \u2014NO 2  and \u2014SF 5 ; \n X 2  is N or CH; \n A is selected from the group consisting of C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  dialkylamino, 3 to 12 membered cycloalkyl, 3 to 12 membered heterocycloalkyl, wherein A is optionally substituted with 1-5 R A  substituents selected from the group consisting of F, Cl, Br, I, \u2014OH, \u2014CN, \u2014NO 2 , \u2014SF 5 , C 1-8  alkyl, C 1-8  haloalkyl, C 1-8  heteroalkyl, -(L A ) 0-1 -3-8 membered cycloalkyl, -(L A ) 0-1 -3-8 membered heterocycloalkyl, -(L A ) 0-1 -5 to 6 membered heteroaryl, -(L A ) 0-1 -C 6  aryl, -(L A ) 0-1 -NR R1a R R1b , -(L A ) 0-1 -OR R1a , -(L A ) 0-1 -SR R1a , -(L A ) 0-1 -N(R R1a )C(\u2550Y 1 )OR R1c , -(L A ) 0-1 -OC(\u2550O)N(R R1a )(R R1b ), -(L A ) 0-1 -N(R R1a )C(\u2550O)N(R R1a )(R R1b ), -(L A ) 0-1 -C(\u2550O)N(R R1a )(R R1b ), -(L A ) 0-1 -N(R R1a )C(\u2550O)R R1b , -(L A ) 0-1 -C(\u2550O)OR R1a , -(L A ) 0-1 -OC(\u2550O)R R1a , -(L A ) 0-1 -P(\u2550O)(OR R1a )(OR R1b ), -(L A ) 0-1 -S(O) 1-2 R R1c , -(L A ) 0-1 -S(O) 1-2 N(R R1a )(R R1b ), -(L A ) 0-1 -N(R R1a )S(O) 1-2 N(R R1a )(R R1b ) and -(L A ) 0-1 -N(R R1a )S(O) 1-2 (R R1c ), wherein L A  is selected from the group consisting of C 1-4  alkylene, C 1-4  heteroalkylene, C 1-4  alkoxylene, C 1-4  aminoalkylene, C 1-4  thioalkylene, C 2-4  alkenylene, and C 2-4  alkynylene; wherein R R1a  and R R1b  are independently selected from the group consisting of hydrogen, C 1-8  alkyl, C 1-8  haloalkyl, 3-8 membered cycloalkyl, phenyl, benzyl, 5 to 6 membered heteroaryl and 3 to 8 membered heterocycloalkyl; R R1c  is selected from the group consisting of C 1-8  alkyl, C 1-8  haloalkyl, 3 to 8 membered cycloalkyl, phenyl, benzyl, 5 to 6 membered heteroaryl and 3 to 7 membered heterocycloalkyl; Y 1  is O or S, and wherein R A  is optionally substituted on carbon atoms and heteroatoms with R RA  substitutents selected from, F, Cl, Br, I, \u2014NH 2 , \u2014OH, \u2014CN, \u2014NO 2 , \u2550O, \u2014SF 5 , C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, C 1-4  (halo)alkyl-C(\u2550O)\u2014, C 1-4  (halo)alkyl-S(O) 0-2 \u2014, C 1-4  (halo)alkyl-N(H)S(O) 0-2 \u2014, C 1-4  (halo)alkyl-S(O) 0-2 N(H)\u2014, (halo)alkyl-N(H)\u2014S(O) 0-2 N(H)\u2014, C 1-4  (halo)alkyl-C(\u2550O)N(H)\u2014, C 1-4  (halo)alkyl-N(H)\u2014C(\u2550O)\u2014, ((halo)alkyl) 2 N\u2014C(\u2550O)\u2014, C 1-4  (halo)alkyl-OC(\u2550O)N(H)\u2014, C 1-4  (halo)alkyl-OC(\u2550O)N(H)\u2014, (halo)alkyl-N(H)\u2014C(\u2550O)O\u2014, ((halo)alkyl) 2 N\u2014C(\u2550O)O\u2014, C 1-4  alkylthio, C 1-4  alkylamino and C 1-4  dialkylamino; and \n Cy is selected from the group consisting of C 1-6  alkyl, C 1-6  haloalkyl, 3 to 12 membered cycloalkyl, 3 to 12 membered heterocycloalkyl, wherein Cy is optionally substituted on carbon or heteroatoms with R Cy  substituents selected from the group consisting of F, Cl, Br, I, \u2014OH, \u2014CN, \u2014NO 2 , \u2014SF 5 , C 1-8  alkyl, C 1-8  haloalkyl, C 1-8  heteroalkyl, -(L Cy ) 0-1 -3-8 membered cycloalkyl, -(L Cy ) 0-1 -3-8 membered heterocycloalkyl, -(L Cy ) 0-1 -5 to 6 membered heteroaryl, -(L Cy ) 0-1 -phenyl, -(L Cy ) 0-1 -NR RCa R RCb , -(L Cy ) 0-1 -OR RCa , -(L Cy ) 0-1 -SR RCa , -(L Cy ) 0-1 -N(R RCa )C(\u2550O)OR RCc , -(L Cy ) 0-1 -OC(\u2550O)N(R RCa )(R RCb ), -(L Cy ) 0-1 -N(R RCa )C(\u2550O)N(R RCa )(R RCb ), -(L Cy ) 0-1 -C(\u2550O)N(R RCa )(R RCb ), -(L Cy ) 0-1 -N(R RCa )C(\u2550O)R RCb , -(L Cy ) 0-1 -C(\u2550O)OR RCa , -(L Cy ) 0-1 -OC(\u2550O)R RCa , -(L Cy ) 0-1 -P(\u2550O)(OR RCa )C(OR RCb ), -(L Cy ) 0-1 -S(O) 1-2 R RCc , -(L Cy ) 0-1 -S(O) 1-2 N(R RCa )(R RCb ), -(L Cy ) 0-1 -N(R RCa )S(O) 1-2 N(R RCa )(R RCb ) and -(L Cy ) 0-1 -N(R RCa )S(O) 1-2 (R RCc ), wherein L Cy  is selected from the group consisting of C 1-4  alkylene, C 1-4  heteroalkylene, C 1-4  alkoxylene, C 1-4  aminoalkylene, C 1-4  thioalkylene, C 2-4  alkenylene, and C 2-4  alkynylene; wherein R RCa  and R RCb  are independently selected from the group consisting of hydrogen, C 1-8  alkyl, C 1-8  haloalkyl, 3-8 membered cycloalkyl, phenyl, benzyl, 5 to 6 membered heteroaryl and 3 to 8 membered heterocycloalkyl; R RCc  is selected from the group consisting of C 1-8  alkyl, C 1-8  haloalkyl, 3 to 8 membered cycloalkyl, phenyl, benzyl, 5 to 6 membered heteroaryl and 3 to 7 membered heterocycloalkyl; Y 1  is O or S, and wherein R Cy  is optionally substituted on carbon atoms and heteroatoms with from 1 to 5 R RCy  substitutents selected from, F, Cl, Br, I, \u2014NH 2 , \u2014OH, \u2014CN, \u2014NO 2 , \u2550O, \u2014SF 5 , C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, C 1-4  (halo)alkyl-C(\u2550O)\u2014, C 1-4  (halo)alkyl-S(O) 0-2 \u2014, C 1-4  (halo)alkyl-N(H)S(O) 0-2 \u2014, C 1-4  (halo)alkyl-S(O) 0-2 N(H)\u2014, (halo)alkyl-N(H)\u2014S(O) 0-2 N(H)\u2014, C 1-4  (halo)alkyl-C(\u2550O)N(H)\u2014, C 1-4  (halo)alkyl-N(H)\u2014C(\u2550O)\u2014, ((halo)alkyl) 2 N\u2014C(\u2550O)\u2014, C 1-4  (halo)alkyl-OC(\u2550O)N(H)\u2014, C 1-4  (halo)alkyl-OC(\u2550O)N(H)\u2014, (halo)alkyl-N(H)\u2014C(\u2550O)O\u2014, ((halo)alkyl) 2 N\u2014C(\u2550O)O\u2014, C 1-4  alkylthio, C 1-4  alkylamino and C 1-4  dialkylamino.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.51351
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15041375', '14267011', '14772735', '14772726', '13899469']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8462997770177296
- 35 USC 102 Novelty (BERT): 0.6017465031318385
- Combined Prediction Score: 0.8218444496291405
- Mean Citation Score: 462.6317
- Max Citation Score: 543.9999
- Similarity Product: 499.1268575590253

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test