PATENT CLAIM ANALYSIS

Application Number: 16228324
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-07
Patent Classification: ["514", "255050"]

Abstract:
The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Claim (Index 3):
The compound of  claim 1 , wherein the compound is Formula I-W6: or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, or isomer thereof, wherein: A is a 5- to 12-membered monocyclic or polycyclic heteroaryl; Y 1  is \u2014S\u2014; Y 2  is \u2014NR a \u2014; wherein the bond on the left side of Y 2 , as drawn, is bound to the pyrazine ring and the bond on the right side of the Y 2  moiety, as drawn, is bound to R 3 ; R 3  is combined with R a  to form a 3- to 12-membered monocyclic or polycyclic heterocycle or a 5- to 12-membered spiroheterocycle, wherein each heterocycle or spiroheterocycle is optionally substituted with one or more \u2014C 1 -C 6 alkyl, \u2014OH, \u2014NH 2 , heteroaryl, heterocyclyl, \u2014(CH 2 ) n NH 2 , \u2014COOR b , \u2014CONHR b , \u2014CONH(CH 2 ) n COOR b , \u2014NHCOOR b , \u2014CF 3 , \u2014CHF 2 , or \u2014CH 2 F; R 1  is independently, at each occurrence, \u2014H, \u2014C 1 -C 6 alkyl, \u2014OH, halogen, \u2014NO 2 , \u2014CN, \u2014NR 5 R 6 , \u2014SR 5 , \u2014C(O)R 5 , or \u2014CO 2 R 5 ; R 2  is \u2014C 1 -C 6 alkyl; R b  is independently, at each occurrence, \u2014H or \u2014C 1 -C 6 alkyl; R 4  is \u2014H, \u2014C 1 -C 6 alkyl, \u2014C 1 -C 6 haloalkyl, \u2014C 1 -C 6 hydroxyalkyl, \u2014CF 2 OH, \u2014CHFOH, \u2014C(O)NH(CH 2 ) n OH, \u2014C(O)NH(CH 2 ) n R b , \u2014C(O)R b , \u2014C(O)NR 5 R 6 , \u2014OH, or \u2014CN, wherein alkyl is optionally substituted with one or more \u2014OH, \u2014NH 2 , halogen, or oxo; or R 5  and R 6  are each independently, at each occurrence, \u2014H or \u2014C 1 -C 6 alkyl; and n is independently, at each occurrence, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 98.0
- Lexical Diversity: 1.125
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16186490', '13352864', '14344628', '14670422', '14670421']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.787297386997627
- 35 USC 102 Novelty (BERT): 0.5409012317842443
- Combined Prediction Score: 0.7626577714762888
- Mean Citation Score: 355.792522
- Max Citation Score: 365.5356
- Similarity Product: 242.2524025819301

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test