PATENT CLAIM ANALYSIS

Application Number: 16322312
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-06
Patent Classification: ["424", "450000"]

Abstract:
The present invention provides a way to capture a biomolecule such as a protein in one or more layers of covalently bonded amorphous silica, forming a cage or shell which preserves the shape of the protein and prevents denaturation caused by heat and/or aging and/or non-physiological conditions, through unfolding and loss of secondary and/or higher order structure.

Claim (Index 51):
A method of releasing a biomolecule from an envelope of silica deposited around the biomolecule, comprising contacting the biomolecule and its envelope of silica with a release solution comprising fluoride ions at acidic pH; or\n a method of enveloping a biomolecule with silica and subsequently releasing the biomolecule from the silica envelope, comprising: a) hydrolysing a silica starting material to produce an aqueous solution of hydrolysed silica precursor, b) contacting the hydrolysed silica precursor with an aqueous solution comprising the biomolecule, wherein the silica precursor precipitates about the biomolecule, and c) contacting the biomolecule and its silica envelope with a release solution comprising fluoride ions at acidic pH.

Metadata:
- Claim Count in Document: 75.0
- Percentile: 99.0
- Lexical Diversity: 1.25
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['10814123', '14111305', '14650645', '11721728', '14374388']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6816587611128231
- 35 USC 102 Novelty (BERT): 0.4778325732348726
- Combined Prediction Score: 0.6612761423250281
- Mean Citation Score: 131.735926
- Max Citation Score: 144.53966
- Similarity Product: 97.98354986918449

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test