PATENT CLAIM ANALYSIS

Application Number: 15914587
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "450000"]

Abstract:
Provided are a pharmaceutical composition of an amorphous vortioxetine or a salt thereof, and a preparation method therefor. The pharmaceutical composition comprises an amorphous vortioxetine or a pharmaceutically acceptable salt thereof and two or more pharmaceutical excipients. The pharmaceutical composition has good stability and dispersity, and enhances the dissolution of vortioxetine or the pharmaceutically acceptable salt thereof, thereby improving the bioavailability of the medicinal formulation and the body absorption of the medicine.

Claim (Index 23):
A method for preparing a pharmaceutical composition of  claim 5 , comprising the following steps:\n 1) mixing vortioxetine hydrobromide salt with at least one organic carrier, at least one adsorbent, and at least one pharmaceutically acceptable excipient and solvent(s) in a fluidized bed, at a mixing temperature from 0\u02dc150\u00b0 C., to form a solution or suspension of the vortioxetine hydrobromide salt, organic carrier, adsorbent, and pharmaceutically acceptable excipient, wherein the weight ratio of vortioxetine hydrobromide salt to the solvent is 0.001\u02dc100:1, the weight of the vortioxetine hydrobromide salt is 20%\u02dc80% of the total weight of solid dispersion, and the weight of the pharmaceutical preparation excipient is 0.1%\u02dc80% of the total weight of the solid dispersion; and 2) removing the solvent in the mixture obtained in step 1) to obtain a composition of amorphous vortioxetine hydrobromide salt.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 90.0
- Lexical Diversity: 1.95
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14916075', '15304929', '14429388', '15048868', '14902326']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7626936399016464
- 35 USC 102 Novelty (BERT): 0.5380726100530175
- Combined Prediction Score: 0.7402315369167836
- Mean Citation Score: 348.08949
- Max Citation Score: 392.5238
- Similarity Product: 272.6545362082124

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test