PATENT CLAIM ANALYSIS

Application Number: 15760343
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "211040"]

Abstract:
The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Claim (Index 1):
A compound represented by: wherein Y is S(O) y , wherein y is 2; R Z  is H; R m\u2032  and R m  are each H; L is a bond or C 1-2 alkylene (optionally substituted by halogen or C 1-2 alkyl); A is a 5-7 membered monocyclic heterocyclic or 5-6 membered monocyclic heteroaryl ring optionally substituted by one or two substituents selected from the group consisting of halogen, hydroxyl, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, and NR\u2032R\u2033; B is selected from the group consisting of phenyl (optionally substituted by one, two or three substituents represented by R 33 ), 5-6 membered monocyclic heteroaryl optionally substituted by one, two or three substituents represented by R 33 ), and 9-10 membered bicyclic heteroaryl (optionally substituted by one, two or three substituents represented by R 33 ); R\u2032 is selected, independently for each occurrence, from H, methyl, ethyl, and propyl; R\u2033 is selected, independently for each occurrence, from H, methyl, ethyl, propyl, (optionally substituted by hydroxyl), butyl (optionally substituted by hydroxyl), \u2014C(O)-methyl and \u2014C(O)-ethyl, or R\u2032 and R\u2033 taken together with the nitrogen to which they are attached may form a 4-7 membered heterocycle optionally substituted by one, two or more substituents selected from the group consisting of halogen, hydroxyl, NH 2 , \u2014C(O)\u2014O\u2014C 1-3 alkyl, \u2014C(O)\u2014C 1-3 alkyl, carboxy, oxo, and C 1-3 alkyl; each of moieties R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10  is independently selected for each occurrence from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkynyl, C 2-6 alkenyl, halogen, hydroxyl, nitro, cyano, and NR\u2032R\u2033; R 33  is independently selected for each occurrence from the group consisting of H, halogen, hydroxyl, nitro, cyano, C 1-6 alkyl, \u2014C(O)\u2014O\u2014C 1-6 alkyl, \u2014C(O)\u2014NR\u2032R\u2033, \u2014C(\u2550NH)\u2014NR\u2032R\u2033, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6  alkoxy, carboxy, \u2014CHO, NR\u2032R\u2033, \u2014C(O)\u2014C 1-6  alkyl, \u2014C(O)\u2014C 1-6 alkoxy, C 3-6 cycloalkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2), and \u2014NR\u2032\u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2); q is 0, 1, 2 or 3; wherein for each occurrence, C 1-6 alkyl may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, \u2014NR\u2032\u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), and S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2); C 1-6 alkoxy may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, NR\u2032R\u2033, \u2014NR\u2032\u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), and S(O) w \u2014NR\u2032R\u2033(where w is 0, 1 or 2); and pharmaceutically acceptable salts and N-oxides thereof.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 90.0
- Lexical Diversity: 1.17949
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15125911', '15030378', '15566633', '12785665', '15450125']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7985508260341504
- 35 USC 102 Novelty (BERT): 0.5426481461683943
- Combined Prediction Score: 0.7729605580475748
- Mean Citation Score: 318.906982
- Max Citation Score: 380.31046
- Similarity Product: 286.55839474907395

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test