PATENT CLAIM ANALYSIS

Application Number: 15758274
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "233200"]

Abstract:
The present invention provides methods for inhibiting Fyn kinase, using 5-3-pyridin-2-amine, 6-3-imidazo[1,2-a] pyrazine, 6-3-imidazo[1,2-b] pyridazine, N-(5-imidazo [2,1-b][1,3,4] thiadiazol-2-yl)-amine, 4-3-1H-pyrazolo[3,4-b] pyridine, and N-(3-imidazo [1,2-b] pyridazin-6-yl) amine compounds and methods of treatment, prevention, inhibition or amelioration of diseases and conditions associated with Fyn kinase using such compounds.

Claim (Index 3):
A compound of formula (I) selected from the group consisting of 3-[2-amino-5-(3,4-dimethoxyphenyl)-3-pyridyl]phenol, 3-[6-amino-5-[3-(dimethylamino)phenyl]-3-pyridyl]-N-(2-hydroxyethyl)benzamide, 5-(3-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[2-amino-5-(4-methylsulfonylphenyl)-3-pyridyl]-2-methoxy-phenol, 4-[2-amino-5-(p-tolyl)-3-pyridyl]-2-methoxy-phenol, 4-[2-amino-5-(3-chlorophenyl)-3-pyridyl]-2-methoxy-phenol, 4-[2-amino-5-(3-fluorophenyl)-3-pyridyl]-2-methoxy-phenol, 4-(2-amino-5-phenyl-3-pyridyl)-2-methoxy-phenol, 4-[6-amino-5-(4-hydroxy-3-methoxy-phenyl)-3-pyridyl]-2,6-dimethyl-phenol, 4-[2-amino-5-(4-fluorophenyl)-3-pyridyl]-2-methoxy-phenol, 4-[2-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]-2-methoxy-phenol, 4-[6-amino-5-[4-(methoxymethoxy)phenyl]-3-pyridyl]benzamide, 3-[6-amino-5-[4-(methoxymethoxy)phenyl]-3-pyridyl]phenyl]methanol, 3-[6-amino-5-[4-(methoxymethoxy)phenyl]-3-pyridyl]benzamide, N-[3-[6-amino-5-[4-(methoxymethoxy)phenyl]-3-pyridyl]phenyl]acetamide, 4-[6-amino-5-[4-(hydroxymethyl)phenyl]-3-pyridyl]-2,6-dimethyl-phenol, 3-[4-(methoxymethoxy)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 3-[2-amino-5-(4-morpholinophenyl)-3-pyridyl]phenol, N-[3-[6-amino-5-(4-hydroxyphenyl)-3-pyridyl]phenyl]acetamide, 4-[2-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]phenol, 4-[2-amino-5-[3-(dimethylamino)phenyl]-3-pyridyl]phenol, 3-[2-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]phenol, 4-[2-amino-5-(4-methylsulfonylphenyl)-3-pyridyl]phenol, 3-(3-aminophenyl)-5-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[2-amino-5-(3-methoxyphenyl)-3-pyridyl]phenol, 4-[6-amino-5-(4-pyridyl)-3-pyridyl]-2,6-dimethyl-phenol, 5-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 5-(3-fluorophenyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]-2,6-dimethyl-phenol, N-[3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]phenyl]methanesulfonamide, 5-phenyl-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]-N-(2-hydroxyethyl)benzamide, 5-(4-aminophenyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]phenol, 5-(4-fluorophenyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]-N-cyclopropyl-benzamide, 5-(benzothiophen-2-yl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]phenol, 5-(6-methoxy-3-pyridyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 5-[3-(dimethylamino)phenyl]-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, [3-[6-amino-5-[3-(dimethylamino)phenyl]-3-pyridyl]phenyl]-(4-methylpiperazin-1-yl)methanone, 4-[6-amino-5-[3-(dimethylamino)phenyl]-3-pyridyl]-2-methoxy-phenol, 3-[3-(dimethylamino)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[6-amino-5-[3-(dimethylamino)phenyl]-3-pyridyl]-2,6-dimethyl-phenol, 3-[3-(dimethylamino)phenyl]-5-(3-pyridyl)pyridin-2-amine, [3-[6-amino-5-[3-(dimethylamino)phenyl]-3-pyridyl]phenyl]methanol, 3-[3-(dimethylamino)phenyl]-5-[6-[3-(dimethylamino)propoxy]-3-pyridyl]pyridin-2-amine, 3-[6-amino-5-[3-(dimethylamino)phenyl]-3-pyridyl]benzamide, 5-(3,4-dimethoxyphenyl)-3-[3-(dimethylamino)phenyl]pyridin-2-amine, 4-[2-amino-5-(3-chloro-4-fluoro-phenyl)-3-pyridyl]-2-methoxy-phenol, 5-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[2-amino-5-(4-methoxyphenyl)-3-pyridyl]-2-methoxy-phenol, 5-(3-furyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 5-(2-phenoxyphenyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]benzamide, 4-[2-amino-5-(3-methoxyphenyl)-3-pyridyl]-2-methoxy-phenol, [4-[2-amino-5-(3,4-dimethoxyphenyl)-3-pyridyl]phenyl]methanol, 5-[4-(4-methylpiperazin-1-yl)phenyl]-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]benzamide, 1-[5-[6-amino-5-[3-(dimethylamino)phenyl]-3-pyridyl]-2-thienyl]ethanone, 5-(4-methylsulfonylphenyl)-3-(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[6-amino-5-(4-hydroxyphenyl)-3-pyridyl]benzamide, 4-[2-amino-5-[4-(4-methylpiperazin-1-yl)phenyl]-3-pyridyl]phenol, 4-[2-amino-5-[4-(4-methylpiperazin-1-yl)phenyl]-3-pyridyl]-2-methoxy-phenol, 4-[6-amino-5-(4-hydroxy-3-methoxy-phenyl)-3-pyridyl]benzamide, 4-[2-amino-5-(4-piperazin-1-ylphenyl)-3-pyridyl]-2-methoxy-phenol, 3,5-bis(3,4,5-trimethoxyphenyl)pyridin-2-amine, 4-[2-amino-5-[4-(4-isopropylpiperazin-1-yl)phenyl]-3-pyridyl]-2-methoxy-phenol, 4-[2-amino-5-(4-morpholinophenyl)-3-pyridyl]-2-methoxy-phenol, and 5-[6-amino-5-[4-(4-methylpiperazin-1-yl)phenyl]-3-pyridyl]-2-methoxy-phenol.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.6383
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13056331', '13057325', '12598882', '13049225', '14554714']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8306429169902113
- 35 USC 102 Novelty (BERT): 0.5336994237666923
- Combined Prediction Score: 0.8009485676678595
- Mean Citation Score: 353.30427799999984
- Max Citation Score: 374.5595
- Similarity Product: 309.31893799990416

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test