PATENT CLAIM ANALYSIS

Application Number: 15890436
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["544", "236000"]

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Claim (Index 5):
The compound of  claim 1 , having Formula (III): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein:\n M is N; \n R 5 , at each occurrence, is independently selected from H, C 1-4  alkyl, \u2014(CR 6 R 6 ) n \u2014C 3-10  carbocycle, and \u2014(CR 6 R 6 ) n -4-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, carbocycle, and heterocycle are substituted with 1-4 R 7 ; \n alternatively, R 5  and R 5  are taken together with the nitrogen atom to which they are attached to form 4- to 10-membered heterocycle substituted with 1-4 R 7 ; \n R 6 , at each occurrence, is independently selected from H and C 1-4  alkyl; \n R 7 , at each occurrence, is independently selected from H, \u2550O, NO 2 , halogen, C 1-4  alkyl, C 1-4  alkoxy, CN, OH, CF 3 , \u2014(CH 2 ) n \u2014CO 2 H, \u2014(CH 2 ) n \u2014CO 2 (C 1-4  alkyl), \u2014(CH 2 ) n \u2014NR 8 R 8 , \u2014NHCO(C 1-4  alkyl), \u2014NHCOCF 3 , \u2014NHCO 2 (C 1-4  alkyl), \u2014NHCO 2 (CH 2 ) 2 O (C 1-4  alkyl), \u2014NHCO 2 (CH 2 ) 3 O (C 1-4  alkyl), \u2014NHCO 2 (CH 2 ) 2 OH, \u2014NHCO 2 (CH 2 ) 2 NH 2 , \u2014NHCO 2 (CH 2 ) 2 N(C 1-4  alkyl) 2 , \u2014NHCO 2 CH 2 CO 2 H, \u2014CH 2 NHCO 2 (C 1-4  alkyl), \u2014NHC(O)NR 8 R 8 , \u2014NHSO 2 (C 1-4  alkyl), \u2014SO 2 NH 2 , \u2014SO 2 NH(C 1-4  alkyl), \u2014SO 2 N(C 1-4  alkyl) 2 , \u2014SO 2 NH(CH 2 ) 2 OH, \u2014SO 2 NH(CH 2 ) 2 O (C 1-4  alkyl), \u2014(CH 2 ) n \u2014CONR 8 R 8 , \u2014O(CH 2 ) n -carbocycle, \u2014O(CH 2 ) n -heterocycle, \u2014NHCO-carbocycle, \u2014NHCO-heterocycle, \u2014(CH 2 ) n -carbocycle, and \u2014(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ; \n R 8 , at each occurrence, is independently selected from H, C 1-4  alkyl, C(O)C 1-4 alkyl, C(O)carbocycle, C(O)heterocycle, \u2014(CH 2 ) n \u2014C(O)NR a R a , C(O)O-alkyl, C(O)O-carbocycle, C(O)O-heterocycle, SO 2 alkyl, SO 2 carbocycle, SO 2 heterocycle, SO 2 NR a R a , \u2014(CH 2 ) n -carbocycle, and \u2014(CH 2 ) n -heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ; \n R 9 , at each occurrence, is independently selected from halogen, OH, NO 2 , CHF 2 , CF 3 , C 1-4  alkyl, C 1-4  alkoxy, CH 2 OH, CO 2 H, CO 2 (C 1-4  alkyl), CONH 2 , \u2014(CH 2 ) n NR a R a , \u2014(CH 2 ) n CONR a R a , \u2014O(CH 2 ) n heterocycle, \u2014O(CH 2 )(2-4)NR a R a , \u2014(CR 10 R 10 ) n -4-10 membered heterocycle, wherein said alkyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R b ; \n n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and \n p, at each occurrence, is independently selected from 0, 1, and 2.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 88.0
- Lexical Diversity: 1.30909
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14759495', '14157564', '14797414', '16067619', '15503419']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8110805577286025
- 35 USC 102 Novelty (BERT): 0.6390279955969403
- Combined Prediction Score: 0.7938753015154363
- Mean Citation Score: 541.344386
- Max Citation Score: 598.7151
- Similarity Product: 581.2235443360628

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test