PATENT CLAIM ANALYSIS

Application Number: 16196789
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["546", "062000"]

Abstract:
The present application relates to securinine or norsecurinine analogues that, when administered to immature myeloid cells, promote differentiation of these cells to mature cells that do not readily proliferate. Therefore, the agents are useful in the treatment of myeloid disorders including myeloproliferative disorders, acute myeloid leukemia, and autoimmune diseases. The agents may also be used as a myeloablative agent in conjunction with a bone marrow transplant or stem cell therapy.

Claim (Index 132):
The method of any one of  claim 1 - 42  or  85 - 95 , wherein myeloid disorder is selected from the group consisting of: acute myeloid leukemia (AML), chronic myeloid leukemia (CML), myelodysplastic syndromes (MDS), myelodysplasia, Myelodysplastic Syndrome (e.g., refractory anemia (RA), refractory anemia with ring sideroblasts (BARS), refractory anemia with excess blasts (RAEB), refractory anemia with excess blasts in transformation (RAEBT), and/or chronic myelomonocytic leukemia (CMMoL)), myeloid sarcoma, chloroma, chronic myeloproliferative diseases (CMPD), essential thrombocythemia, polycythemia vera, chronic myelogenous leukemia, myelofibrosis, myelofibrosis with myeloid metaplasia (MMM\u2014also known as agnogenic myeloid metaplasia or idiopathic myelofibrosis), atypical CMD, chronic neutrophilic leukemia, chronic eosinophilic leukemia, systemic mastocytosis, mast cell disease, chronic neutrophilic leukemia (CNL), chronic eosinophilic leukemia (CEL), hypereosinophilic syndrome (HES), unclassified MPD (UMPD), chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), Down Syndrome related myeloid disorders, and myeloid processes that display overlapping features of MDS and CMPD (hybrid CMD).

Metadata:
- Claim Count in Document: 39.0
- Percentile: 98.0
- Lexical Diversity: 1.36842
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15026916', '14029066', '15262902', '15029943', '15347587']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8063164961624759
- 35 USC 102 Novelty (BERT): 0.6374620963795264
- Combined Prediction Score: 0.789431056184181
- Mean Citation Score: 429.574716
- Max Citation Score: 764.2011
- Similarity Product: 530.4695337104201

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test