PATENT CLAIM ANALYSIS

Application Number: 15755797
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-11
Patent Classification: ["514", "235800"]

Abstract:
The present disclosure pertains to a pharmaceutical combination comprising (a) an alpha-isoform specific PI3K inhibitor, (b) an MDM2 inhibitor, and optionally (c) a BCL-2 inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer a subject in need thereof comprising administering a therapeutically effective amount of such combination.

Claim (Index 46):
The pharmaceutical combination according to  claim 43 , further comprising a BCL-2 inhibitor selected from the group consisting of 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1 cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl] sulfonyl]benzamide or navitoclax; Tetrocarcin A; Antimycin; Gossypol; obatoclax; 2-Amino-6-bromo-4(S)-[1(S)-cyano-2-ethoxy-2-oxoethyl]-4H-1-benzopyran-3-carboxylic acid ethyl ester; Oblimersen; Bak BH3 peptide; (\u2212)-Gossypol acetic acid; 4-[4-[(4\u2032-Chloro[1,1\u2032-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide; and any pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 88.0
- Lexical Diversity: 1.61702
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15755122', '15755140', '13799076', '15861555', '14429367']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7764651580936724
- 35 USC 102 Novelty (BERT): 0.5158752695878777
- Combined Prediction Score: 0.750406169243093
- Mean Citation Score: 292.86425
- Max Citation Score: 317.25934
- Similarity Product: 248.81869976685763

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test