PATENT CLAIM ANALYSIS

Application Number: 16257784
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["435", "183000"]

Abstract:
The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.

Claim (Index 68):
A method for treating or inhibiting or delaying an HBV infection or HBV-associated diseases and pathological conditions, comprising one or more administration(s), to a subject in need thereof, of a therapeutically effective amount of composition comprising a nucleic acid molecule coding for a mutant polypeptide, a vector comprising said nucleic acid molecule, a host cell comprising said nucleic acid molecule or said vector, or any combination thereof,\n wherein said mutant polypeptide comprises a mutated HBV polymerase domain with an internal deletion that functionally disrupts the polymerase activity, wherein said internal deletion is of at least 4 amino acid residues and at most 30 amino acid residues, said mutated polymerase domain comprising:\n the amino acid sequence shown in SEQ ID NO:1 but lacking at least the Tyr residue in position 203, the Met residue in position 204, the Asp residue in position 205, the Asp residue in position 206, the Val residue in position 207, the Val residue in position 208, and the Leu residue in position 209.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 99.0
- Lexical Diversity: 1.48148
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14232082', '15369118', '13423193', '13388826', '13037931']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6898587027278325
- 35 USC 102 Novelty (BERT): 0.6611576358765507
- Combined Prediction Score: 0.6869885960427042
- Mean Citation Score: 607.8404679999999
- Max Citation Score: 773.92725
- Similarity Product: 602.7731610908656

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test