PATENT CLAIM ANALYSIS

Application Number: 16215194
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["548", "118000"]

Abstract:
The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Claim (Index 29):
A method of treating a respiratory disease in a mammal, the method comprising administering to the mammal a pharmaceutical composition comprising a compound of formula (I): wherein:\n X is a group of formula (II): \n n is 0 or 1; R 1  is hydrogen or C 1-3 alkyl; R 2  is hydrogen or C 1-3 alkyl; R 3  is hydrogen or C 1-3 alkyl;\n or R 2  and R 3  taken together form C 2-4 alkylene; \n or, when n is 1, R 3  is selected from hydrogen, \u2014OH, \u2014OC 1-3 alkyl, halo, \u2014C(O)OC 1-3 alkyl, and C 1-3 alkyl, wherein C 1-3 alkyl is optionally substituted with \u2014OH; \n R 4  is hydrogen or C 1-3 alkyl; R 5  is selected from hydrogen, C 1-3 alkyl, \u2014C(O)OC 1-3 alkyl, and phenyl;\n or when n is 1, R 2  and R 5  taken together form C 1-3 alkylene; \n R 6  is hydrogen or C 1-3 alkyl; R 7  is hydrogen or C 1-3 alkyl,\n or when n is 0, R 2  and R 7  taken together form C 1-3 alkylene, or\n R 4  and R 7  taken together form C 2-4 a1kylene or C 1 alkylene-O\u2014C 2 alkylene; \n \n or when n is 1, R 2  and R 7  taken together form C 2 alkylene, optionally substituted with C 1-3 alkyl or R x , \n or R 4  and R 7  taken together form C 1-3 alkylene or \u2014O\u2014C 2 alkylene; \n R 8  is selected from\n (a) hydrogen, \n (b) methyl, optionally substituted with \u2014CN, phenyl or C 3-6 cycloalkyl; \n (c) C 2-6 alkyl, wherein C 2-6 alkyl is optionally substituted with one or two substituents selected from \u2014OH, \u2014OC 1-3 alkyl, \u2014CN, \u2014SC 1-3 alkyl, phenyl, C 3-6 cycloalkyl, halo, and optionally, in addition with two substituents on a single carbon atom taken together to form C 2-3 alkylene; (d) C 3-6 cycloalkyl, wherein C 3-6 cycloalkyl is optionally substituted with \u2014OH, \u2014CN, \u2014OC 1-3 alkyl, or C 1-3 alkyl, wherein C 1-3 alkyl is optionally substituted with \u2014OC 1-3 alkyl or with one or two halo,\n (e) oxetanyl, \n (f) tetrahydropyranyl, \n (g) tetrahydrothiophenyl 1,1-dioxide, and \n (h) phenyl, \n or R 7  and R 8  taken together form C 3-5 alkylene or C 2 alkylene-O\u2014C 2 alkylene; wherein C 3-5 alkylene is optionally substituted with one or two R x ;\n R x  is selected from \u2014OH, \u2014CN, \u2014OC 1-3 alkyl, halo, phenyl, and C 1-3 alkyl which is optionally substituted with \u2014OC 1-3 alkyl or \u2014OH, or \n two substituents R x  taken together form C 1-5 alkylene or \u2014CH 2 OCH 2 \u2014, \n or when n is 1 and R 2  and R 7  taken together form C 2 alkylene, R 4  and a substituent R x  x on C 2 alkylene taken together form C 2 alkylene; \n provided that two substituents IV on the same carbon atom are not both fluoro, and \n provided that when IV is attached to a carbon atom adjacent to a nitrogen atom, IV is not \u2014OH, \u2014OC 1-3 alkyl, or halo; \n or a pharmaceutically-acceptable salt thereof, and a pharmaceutically-acceptable carrier.

Metadata:
- Claim Count in Document: 89.0
- Percentile: 98.0
- Lexical Diversity: 1.375
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15341226', '15915434', '16038424', '15966452', '14451600']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7179092528195277
- 35 USC 102 Novelty (BERT): 0.5535886762284207
- Combined Prediction Score: 0.701477195160417
- Mean Citation Score: 346.68684999999994
- Max Citation Score: 420.26462
- Similarity Product: 316.63817280193086

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test