PATENT CLAIM ANALYSIS

Application Number: 15771430
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "400000"]

Abstract:
A first aspect of the invention relates to novel compounds and more precisely to novel bifunctional prodrugs and drugs. An additional aspect of the invention relates to antibody compound conjugates, wherein the compound is a claimed compound, and to pharmaceutical compositions containing the compound or antibody compound conjugate. The invention lastly relates to the use of this compound or antibody compound conjugates according to the invention in order to treat tumour diseases, particularly in mammals.

Claim (Index 15):
The compound of  claim 2 , wherein\n i) the substrate can be cleaved by a proteolytic, oxidative or reductive enzyme selected from the group consisting of: plasmin, cathepsin, cathepsin B, beta-glucuronidase, galactosidase, mannosidase, glucosidase, neuramidase, saccharosidase, maltase, fructosidase, glycosylases, prostate-specific antigen (PSA), urokinase-type plasminogen activator (u-PA), metalloproteinase, cytochrome P450; ii) the directed enzyme prodrug therapy is selected from the group consisting of ADEPT, VDEPT, MDEPT, GDEPT and PDEPT; iii) R 2  being selected more particularly from a monosaccharide, disaccharide or oligosaccharide, more particularly hexoses, pentoses or heptoses, optionally as deoxy derivative or amino derivative and optionally substituted by halogen, C 1-8  alkyl, C 1-8  acyl, C 1-8  heteroalkyl, C 3-7  cycloalkyl, C 3-7  heterocycloalkyl, C 4-12  aryl or C 4-12  heteroaryl, amino groups or amide groups, or by amino, amido or carboxyl units which may optionally be substituted by halogen, C 1-8  alkyl, C 1-8  acyl, C 1-8  heteroalkyl, C 3-7  cycloalkyl, C 3-7  heterocycloalkyl, C 4-12  aryl or C 4-12  heteroaryl, amino radicals or amide radicals; dextran, dipeptide, tripeptide, tetrapeptide, oligopeptide, peptidomimetics, or combinations thereof.

Metadata:
- Claim Count in Document: 36.0
- Percentile: 91.0
- Lexical Diversity: 1.84091
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14526462', '11997981', '12204082', '10534777', '13641219']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7644058354422328
- 35 USC 102 Novelty (BERT): 0.5082387576234774
- Combined Prediction Score: 0.7387891276603573
- Mean Citation Score: 260.520772
- Max Citation Score: 270.90814
- Similarity Product: 209.3970241122568

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test