PATENT CLAIM ANALYSIS

Application Number: 16271150
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-05
Patent Classification: ["435", "455000"]

Abstract:
A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof.

Claim (Index 12):
The piPSC cells according to  claim 9 , wherein said cells were derived from cells selected from the group consisting essentially of diseased animal and human somatic cells including, but not limited to: mouse primary fibroblast from ALS mice, rat tumor cells, such as 9L-glioma cells, mouse metastatic breast cancer cells, such as 4T1-cells, human breast cancer cell lines, such as MDA-MB-231, human brain tumor cell lines, such as U87 and U251-glioma cells, human primary Stage 4 GBM cells, human primary fibroblasts from Alzheimer patients with apoE3 and apoE4 genotypes.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 99.0
- Lexical Diversity: 1.5283
- Patent Class: 435.0
- Transitional Phrase Type: half
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15808205', '14113522', '12939454', '12997815', '14117589']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7426264480913932
- 35 USC 102 Novelty (BERT): 0.6079487338966173
- Combined Prediction Score: 0.7291586766719156
- Mean Citation Score: 584.3899200000002
- Max Citation Score: 810.3085
- Similarity Product: 471.4240937298238

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test