PATENT CLAIM ANALYSIS

Application Number: 16132506
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["514", "025000"]

Abstract:
The present invention provides a phenylpropanoid compound and a preparation method and use thereof. The phenylpropanoid compound has a structural formula shown as formula (I), and the pharmaceutically acceptable salt has a structural formula shown as formula (II), formula (III), formula (IV), or formula (V). The phenylpropanoid compound and the pharmaceutically acceptable salt thereof have an effect on inhibiting a content of an inflammatory cytokine NO and an expression of an inflammatory cytokine TNF-α, have an effect on inhibiting a hydroxyl radical (—OH), thereby have anti-inflammatory and antioxidant activities, and has a good application prospect in preparing of a medicine for treating an inflammatory disease related to the above factors, such as cervicitis, endometritis, pelvic inflammatory disease, mastitis, sphagitis and/or arthritis.

Claim (Index 8):
A preparation method of the phenylpropanoid compound according to  claim 1 , wherein the preparation method comprises steps as follows:\n S1, taking a root of  Moghania macrophylla  (Willd.) O. Kuntze as a raw material, drying, stripping and slicing, extracting with an ethanol solution to obtain an extracted solution, merging the extracted solution, concentrating till no alcohol taste, obtaining an extractum for future use; S2, dissolving the extractum obtained in the step S1 with water, eluting the dissolved extractum by a macroporous adsorption resin column, with an eluent being an ethanol-water system, collecting first three column volumes of an eluate, naming the eluate as MM-1, for future use; S3, eluting a fraction MM-1 collected in the step S2 by a reverse phase material ODS column chromatography, with an eluent being the ethanol-water system, eluting for 18 column volumes, collecting one fraction of eluate per three column volumes, thereby collecting 6 fractions in order, naming the 6 fractions as MM-11, MM-12, MM-13, MM-14, MM-15, MM-16 respectively, for future use; S4, separating the fraction MM-12 collected in the step S3 by a preparative liquid phase, with a mobile phase being a methanol-water-acetic acid system, collecting eluates in peak-order, collecting 7 fractions in total, naming the 7 fractions as MM-121, MM-122, MM-123, MM-124, MM-125, MM-126, MM-127 respectively, for future use; and S5, purifying the fraction MM-125 collected in the step S4 by the preparative liquid phase, with a mobile phase being the methanol-water-acetic acid system, collecting an eluate, obtaining the phenylpropanoid compound after recrystallizing.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 97.0
- Lexical Diversity: 2.08451
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14914166', '10716506', '10345197', '15449465', '14376481']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7326823740550739
- 35 USC 102 Novelty (BERT): 0.4845615349854255
- Combined Prediction Score: 0.7078702901481091
- Mean Citation Score: 194.021294
- Max Citation Score: 203.82658
- Similarity Product: 165.76778663033247

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test