PATENT CLAIM ANALYSIS

Application Number: 15982514
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["546", "118000"]

Abstract:
Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

Claim (Index 34):
A method for in vivo bioluminescent imaging, the method comprising:\n contacting a live cell with a compound of Formula I or Formula II: wherein R 5  and R 5a  are hydrogen; R 6  and R 6a  are aryl optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, alkylamino, dialkylamino, acyl amino, aminoalkyl, alkyl, fluoroalkyl, alkoxyfluoroalkyl, fluoroalkoxy, alkenyl, alkynyl, haloalkyl, haloalkoxy, heteroalkyl, alkoxy, sulfonylamino, sulfonyl, alkylsulfonyl, amide, carbamate, silyl, substituted silyl, acyl, or aminosulfonyl; R 8  and R 8a  are optionally substituted aryl, heteroaryl, alkyl substituted with aryl, or alkyl substituted with heteroaryl; R x  is halogen, hydroxy, cyano, nitro, amino, alkylamino, dialkylamino, alkyl, alkenyl, alkynyl, alkoxy, or heteroalkyl; and p is 0, 1, 2, 3, 4, or 5; provided that the following compounds are excluded from formula (I): 8-benzyl-2-(furan-2-ylmethyl)-6-phenylimidazo[1,2-a]pyrazin-3 (7H)-one; and 8-benzyl-2-(furan-2-ylmethyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one; and R x  is not 4-hydroxy when p is 1, R 5a  is not hydrogen, or R 8a  is not benzyl, or any combination thereof;\n and \n detecting luminescence; wherein the live cell expresses a coelenterazine-utilizing luciferase.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 93.0
- Lexical Diversity: 1.47619
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15661582', '15887735', '15800649', '15829262', '14608910']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7687879395830095
- 35 USC 102 Novelty (BERT): 0.6151625775333929
- Combined Prediction Score: 0.7534254033780479
- Mean Citation Score: 437.100466
- Max Citation Score: 636.8368
- Similarity Product: 474.2562839706421

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test