PATENT CLAIM ANALYSIS

Application Number: 15776762
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["546", "143000"]

Abstract:
Described are processes for the synthesis of certain compounds, useful for treating diseases, e.g. eye disease, such as glaucoma and ocular hypertension, in a subject.

Claim (Index 21):
A method for the synthesis of a compound of Formula (I): or a pharmaceutically acceptable salt thereof; wherein A is cyclohexyl or phenyl, substituted with 0-3 substituents independently selected from the group consisting of alkyl, halogen, alkoxy, and cyano comprising (a) reacting a compound of Formula (II), wherein PG is a nitrogen protecting group, with 6-aminoisoquinoline to form a compound of Formula (III) wherein A is cyclohexyl or phenyl, substituted with 0-3 substituents independently selected from the group consisting of alkyl, halogen, alkoxy, and cyano; and (b) removing the nitrogen protecting group to form the compound of Formula (I); further comprising: (c) reacting a compound of Formula (IV), wherein A is cyclohexyl or phenyl, substituted with 0-3 substituents independently selected from the group consisting of alkyl, halogen, alkoxy, and cyano; and T is a chiral auxiliary; with wherein PG is a nitrogen protecting group; to form a compound of Formula (V): wherein A is cyclohexyl or phenyl, substituted with 0-3 substituents independently selected from the group consisting of alkyl, halogen, alkoxy, and cyano; and T is a chiral auxiliary; and (d) removing the chiral auxiliary to form the compound of Formula (II).

Metadata:
- Claim Count in Document: 20.0
- Percentile: 93.0
- Lexical Diversity: 1.19231
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14944101', '10307735', '10434387', '11265670', '14916677']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7380960718547313
- 35 USC 102 Novelty (BERT): 0.523566259371563
- Combined Prediction Score: 0.7166430906064144
- Mean Citation Score: 292.3596560000001
- Max Citation Score: 343.1135
- Similarity Product: 335.6725505695344

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test