PATENT CLAIM ANALYSIS

Application Number: 15952951
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["424", "133100"]

Abstract:
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Claim (Index 51):
A method for producing a pharmaceutical composition comprising an antibody, the method comprising:\n producing the antibody using nucleic acid comprising coding sequence encoding the antibody wherein.\n (a) the produced antibody specifically binds to an antigen at a first pH that is in the range of pH 6.7 to pH 10.0, wherein the produced antibody is a molecule comprising an antigen-binding domain and an Fc domain that has FcRn-binding activity, and wherein the produced antibody binds the antigen through the antigen-binding domain; \n (b) the produced antibody specifically binds to the antigen at a second pH that is in the range of pH 4.0 to pH 6.5; \n (c) the binding activity of the produced antibody to the antigen at the first pH is greater than that at the second pH; and \n (d) the produced antibody binds to the antigen in plasma in vivo and dissociates from the bound antigen under conditions present in an endosome in vivo; and formulating the produced antibody in a pharmaceutical composition.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 91.0
- Lexical Diversity: 1.31818
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13889484', '15952945', '13889512', '13595139', '12680087']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7288119383037588
- 35 USC 102 Novelty (BERT): 0.6724522049860405
- Combined Prediction Score: 0.723175964971987
- Mean Citation Score: 707.154606
- Max Citation Score: 794.39703
- Similarity Product: 646.0168256029665

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test