PATENT CLAIM ANALYSIS

Application Number: 15914782
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "093210"]

Abstract:
Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.

Claim (Index 6):
A composition comprising an induced sinoatrial body in a pharmaceutically acceptable buffer and/or cellular support medium, wherein the sinoatrial body is made by the following method:\n a) sequentially expressing SHOX2>TBX5>HCN2 in a population of adult adipose tissue-derived stem cells in order to induce specific differentiation of said cells, and b) growing said cells until cardiac pacemaker cells and Purkinje cells form.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 90.0
- Lexical Diversity: 1.29167
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14980274', '14357195', '11022172', '15550572', '10342506']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7294072085695408
- 35 USC 102 Novelty (BERT): 0.7218140465981648
- Combined Prediction Score: 0.7286478923724032
- Mean Citation Score: 432.26163
- Max Citation Score: 845.3718
- Similarity Product: 765.7653259848475

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test