PATENT CLAIM ANALYSIS

Application Number: 15908526
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-10
Patent Classification: ["435", "069600"]

Abstract:
The present invention contemplates a method of producing a recombinant protein comprising (a) fermenting a prokaryotic host cell wherein said prokaryotic host cell has been transformed with a nucleic acid encoding said recombinant protein, and (b) harvesting said recombinant protein under conditions where dO 2  levels are greater than 0%, and (c) purifying said recombinant protein to a filtered bulk, wherein said filtered bulk does not contain detectable DHNA-recombinant protein adduct, as measured by an IEC assay at 310 nm. The present invention also contemplates a method of producing a recombinant protein comprising (a) fermenting a menE gene-deleted prokaryotic host cell wherein said prokaryotic host cell has been transformed with a nucleic acid encoding said recombinant protein, (b) harvesting said recombinant protein; and (c) purifying said recombinant protein to a filtered bulk, wherein said filtered bulk does not contain detectable DHNA-recombinant protein adduct, as measured by an IEC assay at 310 nm, and wherein the recombinant protein yield is increased by about 20% or greater.

Claim (Index 20):
The method of  claim 1 , wherein the fermentation is scale-independent.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 88.0
- Lexical Diversity: 2.60274
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14497964', '13844261', '15643788', '14922802', '13668182']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6114924862714539
- 35 USC 102 Novelty (BERT): 0.6097362794721335
- Combined Prediction Score: 0.611316865591522
- Mean Citation Score: 274.297882
- Max Citation Score: 524.8495
- Similarity Product: 519.8943550848663

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test