PATENT CLAIM ANALYSIS

Application Number: 16065880
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["544", "293000"]

Abstract:
The invention relates to Crystal form I and Crystal form II of dihydrochloride of N-(4-((3-chloro-4-fluorophenyl)amino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazoli n-6-yl)acrylamide represented by the following Formula (I), and preparation methods therefor, wherein the Crystal form I has an X-ray powder diffraction pattern having characteristic peaks at the 2θ positions of 6.0±0.2°, 7.3±0.2°, 11.7±0.2°, 12.9±0.2°, 18.4±0.2°, 24.7±0.2°, and 26.3±0.2°, as determined by using Cu-Kα radiation, and the Crystal form II has an X-ray powder diffraction pattern having characteristic peaks at the 2θ positions of 5.0±0.2°, 7.0±0.2°, 10.1±0.2°, 17.0±0.2°, 26.0±0.2°, and 26.5±0.2°, as determined by using Cu-Kα radiation.

Claim (Index 21):
A method for treating a disease selected from hyperproliferative disease and chronic obstructive pulmonary disease, comprising the step of administering to a subject in need thereof the Crystal form I according to  claim 1 ;\n wherein the hyperproliferative disease is selected from the group consisting of cancer and noncancerous disease; the cancer is selected from the group consisting of brain tumor, lung cancer, squamous epithelial cell cancer, bladder cancer, gastric cancer, ovarian cancer, peritoneal cancer, pancreatic cancer, breast cancer, head and neck cancer, cervical cancer, endometrial cancer, colorectal cancer, liver cancer, renal cancer, esophageal adenocarcinoma, esophageal squamous cell carcinoma, non-Hodgkin's lymphoma, central nervous system tumor, prostate cancer and thyroid cancer; the noncancerous disease is benign hyperplasia of skin or prostate.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 98.0
- Lexical Diversity: 1.94118
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16065884', '14127824', '13701704', '15328795', '15748283']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7567632726178112
- 35 USC 102 Novelty (BERT): 0.5866302934963706
- Combined Prediction Score: 0.7397499747056672
- Mean Citation Score: 370.674532
- Max Citation Score: 546.69147
- Similarity Product: 396.39828427474566

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test