PATENT CLAIM ANALYSIS

Application Number: 15956563
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-12
Patent Classification: ["514", "017700"]

Abstract:
A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor-neuronal protein interaction. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARs) to pathways mediating excitotoxicity, ischemic and traumatic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95/NMDAR interaction complex. This treatment attenuated downstream NMDAR signaling without blocking NMDAR activity, protected cultured cortical neurons from excitotoxic insults, dramatically reduced cerebral infarction volume in rats subjected to transient focal cerebral ischemia, and traumatic brain injury (TBI) in rats.

Claim (Index 1):
A method of inhibiting the binding between a N-methyl-D-aspartate receptor and a neuronal protein in a neuron said method comprising administering to said neuron an effective inhibiting amount of a peptide replacement agent for the N-methyl-D-aspartate receptor or the neuronal protein to effect said inhibition of the binding between the N-methyl-D-aspartate receptor and the neuronal protein

Metadata:
- Claim Count in Document: 27.0
- Percentile: 91.0
- Lexical Diversity: 1.5534
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['10930192', '12392988', '10208374', '12557884', '11894818']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8350618521919654
- 35 USC 102 Novelty (BERT): 0.6187896869200941
- Combined Prediction Score: 0.8134346356647782
- Mean Citation Score: 625.6724059999998
- Max Citation Score: 715.7699
- Similarity Product: 477.6469817211747

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test