PATENT CLAIM ANALYSIS

Application Number: 15895120
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "003800"]

Abstract:
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.

Claim (Index 1):
A compound having a structure of formula I or a pharmaceutically acceptable salt thereof, wherein X is O, NH, or N-alkyl; Y is NH, N-alkyl, O, or C(R 9 ) 2 ; Z is O or C(R 9 ) 2 ; R 1 , R 2 , R 3 , and R 4  are all hydrogen; each R 5 , R 6 , R 7 , R 8 , and R 9  is independently selected from hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxyalkyl, aryl, and C 1-6 aralkyl, each of which is optionally substituted with a group selected from alkyl, amide, amine, carboxylic acid or a pharmaceutically acceptable salt thereof, carboxyl ester, thiol, and thioether; R 10  and R 11  are independently selected from hydrogen and C 1-6 alkyl, or R 10  and R 11  together form a 3- to 6-membered carbocyclic or heterocyclic ring; R 12  and R 13  are independently selected from hydrogen, a metal cation, C 1-6 alkyl, and C 1-6 aralkyl, or R 12  and R 13  together represent C 1-6 alkyl, thereby forming a ring; m is an integer from 0 to 2; and n is an integer from 0 to 2, preferably 0 or 1.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 88.0
- Lexical Diversity: 1.46032
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11199899', '11578626', '11596028', '11106879', '11786217']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8448616861810615
- 35 USC 102 Novelty (BERT): 0.5701418790518499
- Combined Prediction Score: 0.8173897054681404
- Mean Citation Score: 419.831592
- Max Citation Score: 430.53482
- Similarity Product: 423.1629844897605

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test