PATENT CLAIM ANALYSIS

Application Number: 16069814
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "490000"]

Abstract:
Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I, wherein X is C═O or CH 2 ; Y is NH, O or absent; R is a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compounds provided slowly release 2-tert-butyl-4-methoxyphenol in vivo and maintain stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T½=12˜24 h). The compounds provided by the present invention protect the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoid environmental oxidation and increase the environmental stability of drugs containing the compounds.

Claim (Index 4):
The compounds, the salts, the hydrates or the solvates according to  claim 3 , wherein: the compound is:\n 1) (2-tert-butyl-4-methoxyphenol) (N-benzyl)carbamate, 2) (2-tert-butyl-4-methoxyphenol) (N-n-butyl)carbamate, 3) (2-tert-butyl-4-methoxyphenol) (N-isopropyl)carbamate, 4) (2-tert-butyl-4-methoxyphenol) (N-cyclohexyl)carbamate, 5) (2-tert-butyl-4-methoxyphenol) (N-phenethyl)carbamate, 6) pivaloyl(2-tert-butyl-4-methoxyphenol-oxyl) methyl ester, 7) 2-tert-butyl-4-methoxyphenol benzoate, 8) 2-tert-butyl-4-methoxyphenol acetate, 9) 2-tert-butyl-4-methoxyphenol nicotinate, 10) 2-tert-butyl-4-methoxyphenol isonicotinate, 11) 2-tert-butyl-4-methoxyphenol cyclohexenecarboxylate, 12) 2-tert-butyl-4-methoxyphenol propionate, 13) 2-tert-butyl-4-methoxyphenol acrylate, 14) (2-tert-butyl-4-methoxyphenol) 3,4-dimethoxyphenylacetate, 15) 2-tert-butyl-4-methoxyphenol butynoate, 16) bis(2-tert-butyl-4-methoxyphenol) 2,2\u2032-biphenyldicarboxylate, 17) (2-tert-butyl-4-methoxyphenol) 2-chloro-5-trifluoromethylbenzoate, 18) (2-tert-butyl-4-methoxyphenol) 3-fluorophenylacetate, 19) (2-tert-butyl-4-methoxyphenol) (1H-indole-3-yl)acetate, 20) (2-tert-butyl-4-methoxyphenol) 3-(4-fluorophenyl)-propionate, 21) (2-tert-butyl-4-methoxyphenol) N-tert-butoxycarbonylpiperidine-3-formate, 22) di(2-tert-butyl-4-methoxyphenol) terephthalate, 23) (2-tert-butyl-4-methoxyphenol) 3-(3-nitrophenyl)propionate, 24) (2-tert-butyl-4-methoxyphenol) 4-phenylbenzoate, 25) (2-tert-butyl-4-methoxyphenol) 4-methylpyridine-3-formate, 26) (2-tert-butyl-4-methoxyphenol) 4-methoxypyridine-3-formate, 27) 2-tert-butyl-4-methoxyphenol hexadecylate, 28) N-tert-butoxycarbonylglycine(2-tert-butyl-4-methoxyphenol)ester, 29) (2-tert-butyl-4-methoxyphenol) 3-fluoro-4-chlorobenzoate, 30) N-tert-butoxycarbonyltetrahydropyrrole, (2-tert-butyl-4-methoxyphenol) benzoheterocycle-3-formate, 31) (2-tert-butyl-4-methoxyphenol) 3-cyanobenzoate, 32) (2-tert-butyl-4-methoxyphenol) N-tert-butoxycarbonylalaninate, 33) (2-tert-butyl-4-methoxyphenol) 2-naphthoate, 34) di(2-tert-butyl-4-methoxyphenol) malonate, 35) (2-tert-butyl-4-methoxyphenol) 3,6-dichloropyridazine-4-formate, 36) (2-tert-butyl-4-methoxyphenol) 1-methylcyclopropyl formate, 37) (2-tert-butyl-4-methoxyphenol) 2-indoleformate, 38) (2-tert-butyl-4-methoxyphenol) 2-chloro-3-picolinate, 39) (2-tert-butyl-4-methoxyphenol) 2-thiopheneacetate, 40) (2-tert-butyl-4-methoxyphenol) 3-(4-methylphenyl)-propionate, 41) (2-tert-butyl-4-methoxyphenol) propiolate, 42) (2-tert-butyl-4-methoxyphenol) 2-phenyl propionate, 43) (2-tert-butyl-4-methoxyphenol) 2-fluoropropionate, 44) (2-tert-butyl-4-methoxyphenol) cyclohexyl acetate, 45) (2-tert-butyl-4-methoxyphenol) cyclopentanecarboxylate, 46) (2-tert-butyl-4-methoxyphenol) adamantaneacetate, 47) (2-tert-butyl-4-methoxyphenol) cyclopropylacetate, 48) (2-tert-butyl-4-methoxyphenol) N-tert-butoxycarbonylpiperidine-4-formate, 49) (2-tert-butyl-4-methoxyphenol) octanoate, 50) (2-tert-butyl-4-methoxyphenol) 7-oxooctanoate, 51) (2-tert-butyl-4-methoxyphenol) cyclohexene-2-carboxylate, 52) (2-tert-butyl-4-methoxyphenol) 2,4,5-trifluorophenylacetate, 53) (2-tert-butyl-4-methoxyphenol) 2-bromo-5-iodo benzoate, 54) (2-tert-butyl-4-methoxyphenol) 2-fluoro-4-nitryl benzoate, 55) (2-tert-butyl-4-methoxyphenol) N-tert-butoxycarbonylpiperidine-3-formate, 56) di(2-tert-butyl-4-methoxyphenol) p-phenylenediacetate, 57) (2-tert-butyl-4-methoxyphenol) 4-benzoyl butyrate, 58) (2-tert-butyl-4-methoxyphenol) 3,5-dimethoxy phenylpropenoate, 59) (2-tert-butyl-4-methoxyphenol) 4-chloropyridine-2-formate, 60) (2-tert-butyl-4-methoxyphenol) N-methylpiperidine-3-formate, 61) (2-tert-butyl-4-methoxyphenol) N-tert-butoxycarbonyl-6-amino pentanoate, 62) (2-tert-butyl-4-methoxyphenol) 3,3,3-trifluoropropionate, 63) (2-tert-butyl-4-methoxyphenol) morpholin-4-yl acetate, 64) (2-tert-butyl-4-methoxyphenol) 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)propionate, 65) di(2-tert-butyl-4-methoxyphenol) adipate, or 66) 2-(2-tert-butyl-4-methoxyphenoxy) ethyl acetate.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 95.0
- Lexical Diversity: 1.92593
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['11270780', '11737938', '11302307', '12126437', '13511292']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.785094105219544
- 35 USC 102 Novelty (BERT): 0.5091583568192186
- Combined Prediction Score: 0.7575005303795115
- Mean Citation Score: 261.405114
- Max Citation Score: 277.76654
- Similarity Product: 203.15182848824503

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test