PATENT CLAIM ANALYSIS

Application Number: 15756908
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "006100"]

Abstract:
The invention relates to the use of certain micro-RNAs circulating in the blood serum or blood plasma in the form of diagnostic profiles as a marker in an in vitro method for distinguishing between patients for which a myocardial biopsy is necessary for the diagnostic identification of a heart muscle disease and patients for which myocardial biopsy is not necessary, and for the optional differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases affecting the heart.

Claim (Index 1):
An in-vitro or in-vivo method for differentiating between patients requiring, for the diagnostic identification of a myocardial disorder, myocardial biopsy, and patients not requiring myocardial biopsy, and for the optional differential diagnostic differentiation between individual non-ischemic cardiomyopathies or storage diseases of the heart, wherein:\n a blood serum/blood plasma sample of a patient is analyzed using a diagnostic profile comprising at least 2 microRNAs or synthetic nucleic acids having identical or complementary sequences, selected from the group consisting of the following microRNAs:\n hsa-let-7f-5p (SEQ ID NO: 10), hsa-miR-103a-3p (SEQ ID NO: 11), hsa-miR-197-3p (SEQ ID NO: 12), hsa-miR-215-5p (SEQ ID NO: 13), hsa-miR-223-3p (SEQ ID NO: 14), hsa-miR-23a-3p (SEQ ID NO: 15), hsa-miR-330-3p (SEQ ID NO: 16), hsa-miR-337-5p (SEQ ID NO: 17), hsa-miR-339-3p (SEQ ID NO: 18), hsa-miR-339-5p (SEQ ID NO: 19), hsa-miR-411-5p (SEQ ID NO: 20), hsa-miR-454-3p (SEQ ID NO: 21), hsa-miR-485-3p (SEQ ID NO: 22), hsa-miR-487b-3p (SEQ ID NO: 23), hsa-miR-494-3p (SEQ ID NO: 24), hsa-miR-505-3p (SEQ ID NO: 25), hsa-miR-628-5p (SEQ ID NO: 26), hsa-miR-671-3p (SEQ ID NO: 27), hsa-miR-744-5p (SEQ ID NO: 28), hsa-miR-889-3p (SEQ ID NO: 29), mmu-miR-495-3p (SEQ ID NO: 30).

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.56
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13899555', '14788843', '15320208', '13642321', '15237364']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.639270059171222
- 35 USC 102 Novelty (BERT): 0.5232095915000915
- Combined Prediction Score: 0.627664012404109
- Mean Citation Score: 338.831186
- Max Citation Score: 342.94568
- Similarity Product: 222.11420817675588

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test