PATENT CLAIM ANALYSIS

Application Number: 15777223
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "030000"]

Abstract:
The invention provides novel compounds that are derivatives of Azithromycin and that have been found by the current inventors to have low antimicrobial activity but significant epithelial barrier enhancement properties. The invention further provides use of the compounds as a medicament, in particular in the treatment or prophylaxis of a disease or condition that is caused by a defect in epithelial cells or tissue, or a disease or condition that benefits from enhancement or restoration of epithelial barrier function, for example diseases of the respiratory tract.

Claim (Index 19):
The compound according to  claim 18 , wherein\n R 7  is selected from the group consisting of C 1-3 -alkyl, C 6-10 -aryl-C 1-3 -alkyl, linear or branched C 3-4 -alkylcarbonyl, C 6-10 -arylcarbonyl, C 6-10 -aryl-C 1-3 -alkylcarbonyl, C 6-10 -aryl-O\u2014C 1-3 -alkylcarbonyl, C 6-10 -aryl-C 1-3 -alkyl-O\u2014C 1-3 -alkyl-carbonyl, HOOC\u2014(CH 2 ) m \u2014(CO)\u2014 with m being from 0 to 3, a moiety according to formula (V.2) wherein Ar is C 6-10 -aryl and n, p and q each are independently from 0 to 3, C 6-10 -aryl-C 1-3 -alkyl-O\u2014CO\u2014NH\u2014C 1-3 -alkyl-CO\u2014, C 6-10 -arylsulfonyl, and C 1-3 -alkyl-C 6-10 -arylsulfonyl; R 8  is selected from the group consisting of C 6-10 -arylcarbonyl, C 6-10 -arylcarbonyl substituted with 1 to 3 halogen atoms, C 1-2 -alkyl groups and/or C 1-2 -alkoxy groups, linear or branched C 3-4 -alkylcarbonyl, HOOC\u2014(CH 2 ) m \u2014(CO)\u2014 with m being from 0 to 3, a moiety according to formula (V.2) as depicted hereinbefore wherein Ar is C 6-10 -aryl and n, p and q each are independently from 0 to 3, C 1-3 -alkylsulfonyl-bi-C 6-10 -aryl-carbonyl, and heteroarylcarbonyl having a 5-, 6- or 10-membered ring containing 1, 2 or 3 heteroatoms, with the heteroatom(s) in each case being selected from the group consisting of N, O and S, the ring of the heteroarylcarbonyl optionally being substituted by 1 or 2 substituents selected from the group consisting of C 1-2 -alkyl, C 1-2 -alkoxy, C 2-3 -alkenyl, C 2-3 -alkenoxy, halogen.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 1.625
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14902129', '10421577', '10218154', '10840529', '09485292']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8470845480940636
- 35 USC 102 Novelty (BERT): 0.5503936788221534
- Combined Prediction Score: 0.8174154611668726
- Mean Citation Score: 400.387328
- Max Citation Score: 434.61444000000006
- Similarity Product: 317.7132872044945

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test