PATENT CLAIM ANALYSIS

Application Number: 15868272
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "006400"]

Abstract:
The invention is a pharmaceutical composition of human insulin or insulin analog that includes citrate, treprostinil and stabilizing agents, that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products and that is stable for commercial use.

Claim (Index 51):
The pharmaceutical composition of  claim 34  wherein:\n a. the insulin is insulin lispro, and is present in a concentration from about 100 to about 200 U/mL; \n b. citrate is in a concentration of about 15 mM; \n c. treprostinil is in a concentration of about 1 \u03bcg/mL; \n d. the preservative is m-cresol, and is present in a concentration of about 3.15 mg/mL; and \n e. zinc is in a concentration from about 0.6 to about 0.8 mM; \n and wherein the pharmaceutical composition further comprises:\n f. glycerol, in a concentration of about 12 mM; and \n g. magnesium chloride, in a concentration of about 5 mM; \n and wherein the pharmaceutical composition does not contain EDTA, any additional vasodilatory agents or any oligosaccharides; and wherein the pharmaceutical composition provides for an uptake of insulin into the blood, as measured by early \u00bd Tmax, that is at least 20% more rapid than for compositions which contain the same insulin but which do not contain citrate or treprostinil; and wherein the pharmaceutical composition is stable to allow for (i) storage of at least 24 months at 2-8\u00b0 C., (ii) up to 28 days in-use at temperatures of up to 30\u00b0 C. for vials or cartridges in re-usable pen injectors, and (iii) use in a pump device for continuous subcutaneous insulin infusion therapy for up to 7 days.

Metadata:
- Claim Count in Document: 77.0
- Percentile: 86.0
- Lexical Diversity: 1.29412
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15241412', '14963279', '14781342', '15259101', '13507262']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7293104155502061
- 35 USC 102 Novelty (BERT): 0.556760869663952
- Combined Prediction Score: 0.7120554609615808
- Mean Citation Score: 340.59009
- Max Citation Score: 409.67368
- Similarity Product: 327.9414511241245

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test