PATENT CLAIM ANALYSIS

Application Number: 16047544
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-05
Patent Classification: ["544", "280000"]

Abstract:
The present invention provides cyclobutyl substituted pyrrolopyrimidines and pyrrolopyridines of Formula I: wherein X, Y, Z, L, A, R 5 , n and m are defined above, as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Claim (Index 26):
The compound accordingly to  claim 1 , or a pharmaceutically acceptable salt thereof, wherein:\n R 1 , R 2 , and R 3  are each H; Y is cyano; L is C(R 6 ) 2 , C(\u2550O), C(\u2550O)O, C(\u2550O)N(R 7 ), S(\u2550O) 2 , or S(\u2550O) 2 N(R 7 ); or R 6  is H; R 7  is H or methyl; A is methyl, ethyl, propyl, isopropyl, isobutyl, sec-butyl, 1,2-dimethylpropyl, 1-(tert-butyl)methyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, a tetrahydropyran ring, a pyrrolidine ring, a piperidine ring, a pyridine ring, a pyrimidine ring, a thiazole ring, or a pyrazine ring; each of which is optionally substituted with p independently selected R 8  substituents; each R 8  is independently selected from halo, cyano, C 1-6  alkyl, C 1-6  haloalkyl, C 3-7  cycloalkyl, C 2-7  heterocycloalkyl, \u2014OR a , \u2014C(\u2550O)OR a , or \u2014NR e R f ; wherein said C 1-6  alkyl is optionally substituted by 1, 2, 3, or 4 independently selected R g  groups; and wherein each R a , R e , and R f  is independently selected from H, C 1-6  alkyl, and C 1-6  haloalkyl; each R g  is independently selected from C 2-7  heterocycloalkyl, \u2014OR a1 , and \u2014NR e1 R f1 ; wherein said C 2-7  heterocycloalkyl is optionally substituted by 1 or 2 R h  groups independently selected from fluoro, OH, C 1-3  alkyl, alkoxy, and hydroxy-C 1-4  alkyl; and wherein each R a1 , R e1  and R f1  are independently selected from H, C 3-7  cycloalkyl, and C 1-6  alkyl; p is 1, 2, or 3; m is 1; and n is 0.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.49123
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13300094', '13300137', '12872925', '13896802', '13588776']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7860489225113861
- 35 USC 102 Novelty (BERT): 0.6523382895977209
- Combined Prediction Score: 0.7726778592200196
- Mean Citation Score: 523.41831
- Max Citation Score: 591.9107
- Similarity Product: 549.7712015709221

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test