PATENT CLAIM ANALYSIS

Application Number: 15881568
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-10
Patent Classification: ["424", "186100"]

Abstract:
To overcome the limitations of existing particle quantification techniques, the inventors used disc centrifugation in combination with a detector, to quantify particles, in particular virus particles. Also provided is a method for determining particle density using a disc centrifuge. This method is particularly useful for determining virus particle density. Also provided is a method of estimating particle size, based on particle density.

Claim (Index 53):
A method for preparing a vaccine, comprising a step of quantifying virus particles in a sample comprising:\n a. separating particles in the sample by disc centrifugation; b. detecting the particles using a particle detector; c. measuring the particle size distribution; d. identifying the presence or absence of:\n i. non-aggregated virus particles, based on the presence of a unimodal size distribution; and/or \n ii. aggregated virus particles, based on the presence of a multimodal size distribution; \n e. determining:\n i. the maximum weight of the size distribution and/or the integrated weight of the size distribution for a sample comprising non-aggregated virus particles; or \n ii. the integrated weight of the size distribution for a sample comprising aggregated virus particles; \n f. comparing (i) the maximum weight of the size distribution for the sample with the maximum weight of the size distribution of a reference, and/or (ii) comparing the integrated weight of the size distribution for the sample with integrated weight of the size distribution of a reference, and thereby quantifying the virus particles in the sample.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.70732
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13280043', '15287433', '13297125', '14149365', '15326143']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.69543890927225
- 35 USC 102 Novelty (BERT): 0.5028486617867721
- Combined Prediction Score: 0.6761798845237023
- Mean Citation Score: 213.61743
- Max Citation Score: 216.99673
- Similarity Product: 133.85399715877534

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test