PATENT CLAIM ANALYSIS

Application Number: 16248746
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["424", "001650"]

Abstract:
Described are methods and materials for use in the treatment or prophylaxis of diseases, for example cognitive disorders, using diaminophenothiazines. In particular it relates to treatments having optimised pharmacokinetic properties, and dosage forms are intended to improve the relative cognitive or CNS benefits of the diaminophenothiazines, for instance compared to haematological effects.

Claim (Index 10):
A method as claimed in  claim 1  wherein said DAPTZ compound is selected from compounds of the following formulae and pharmaceutically acceptable salts, mixed salts, solvates, and hydrates thereof: wherein each one of R 1 , R 2 , R 4 , R 6 , R 8 , and R 9  is independently selected from: \u2014H; \u2014F; \u2014Cl; \u2014Br; \u2014I; \u2014OH; \u2014OR; \u2014SH; \u2014SR; \u2014NO 2 ; \u2014C(\u2550O)R; \u2014C(\u2550O)OH; \u2014C(\u2550O)OR; \u2014C(\u2550O)NH 2 ; \u2014C(\u2550O)NHR; \u2014C(\u2550O)NR 2 ; \u2014C(\u2550O)NR N1 R N2 ; \u2014NH 2 ; \u2014NHR; \u2014NR 2 ; \u2014NR N1 R N2 ; \u2014NHC(\u2550O)H; \u2014NRC(\u2550O)H; \u2014NHC(\u2550O)R; \u2014NRC(\u2550O)R;\n \u2014R; \n wherein each R is independently selected from:\n unsubstituted aliphatic C 1-6 alkyl; substituted aliphatic C 1-6 alkyl; \n unsubstituted aliphatic C 2-6 alkenyl; substituted aliphatic C 2-6 alkenyl; \n unsubstituted C 3-6 cycloalkyl; substituted C 3-6 cycloalkyl; \n unsubstituted C 6-10 carboaryl; substituted C 6-10 carboaryl; \n unsubstituted C 5-10 heteroaryl; substituted C 5-10 heteroaryl; \n unsubstituted C 6-10 carboaryl-C 1-4 alkyl; substituted C 6-10 carboaryl-C 1-4 alkyl; \n wherein, in each group \u2014NR N1 R N2 , independently, R N1  and R N2  taken together with the nitrogen atom to which they are attached form a ring having from 3 to 7 ring atoms; and wherein, in each group \u2014NR 3NA R 3NA , if present: each one of R 3NA  and R 3NB  is independently selected from: \u2014H;\n unsubstituted aliphatic C 1-6 alkyl; substituted aliphatic C 1-6 alkyl; \n unsubstituted aliphatic C 2-6 alkenyl; substituted aliphatic C 2-6 alkenyl; \n unsubstituted C 3-6 cycloalkyl; substituted C 3-6 cycloalkyl; \n unsubstituted C 6-10 carboaryl; substituted C 6-10 carboaryl; \n unsubstituted C 5-10 heteroaryl; substituted C 5-10 heteroaryl; \n unsubstituted C 6-10 carboaryl-C 1-4 alkyl; substituted C 6-10 carboaryl-C 1-4 alkyl; \n or: R 3NA  and R 3NB  taken together with the nitrogen atom to which they are attached form a ring having from 3 to 7 ring atoms; and wherein, in each group \u2550NR 3NC , if present, R 3NC  is independently selected from:\n \u2014H; \n unsubstituted aliphatic C 1-6 alkyl; substituted aliphatic C 1-6 alkyl; \n unsubstituted aliphatic C 2-6 alkenyl; substituted aliphatic C 2-6 alkenyl; \n unsubstituted C 3-6 cycloalkyl; substituted C 3-6 cycloalkyl; \n unsubstituted C 6-10 carboaryl; substituted C 6-10 carboaryl; \n unsubstituted C 5-10 heteroaryl; substituted C 5-10 heteroaryl; \n unsubstituted C 6-10 carboaryl-C 1-4 alkyl; substituted C 6-10 carboaryl-C 1-4 alkyl; \n and wherein, in each group \u2014NR 7NA R 7NA , if present: each one of R 7NA  and R 7NB  is independently selected from:\n \u2014H; \n unsubstituted aliphatic C 1-6 alkyl; substituted aliphatic C 1-6 alkyl; \n unsubstituted aliphatic C 2-6 alkenyl; substituted aliphatic C 2-6 alkenyl; \n unsubstituted C 3-6 cycloalkyl; substituted C 3-6 cycloalkyl; \n unsubstituted C 6-10 carboaryl; substituted C 6-10 carboaryl; \n unsubstituted C 5-10 heteroaryl; substituted C 5-10 heteroaryl; \n unsubstituted C 6-10 carboaryl-C 1-4 alkyl; substituted C 6-10 carboaryl-C 1-4 alkyl; \n or: R 7NA  and R 7NB  taken together with the nitrogen atom to which they are attached form a ring having from 3 to 7 ring atoms; and wherein, in each group \u2550NR 7NC , if present, R 7NC  is independently selected from:\n \u2014H; \n unsubstituted aliphatic C 1-6 alkyl; substituted aliphatic C 1-6 alkyl; \n unsubstituted aliphatic C 2-6 alkenyl; substituted aliphatic C 2-6 alkenyl; \n unsubstituted C 3-6 cycloalkyl; substituted C 3-6 cycloalkyl; \n unsubstituted C 6-10 carboaryl; substituted C 6-10 carboaryl; \n unsubstituted C 5-10 heteroaryl; substituted C 5-10 heteroaryl; \n unsubstituted C 6-10 carboaryl-C 1-4 alkyl; substituted C 6-10 carboaryl-C 1-4 alkyl; \n and wherein X \u2212 , if present, is one or more anionic counter ions to achieve electrical neutrality.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 99.0
- Lexical Diversity: 1.38095
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14866035', '12681511', '12294605', '12665608', '14248730']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7886987694119205
- 35 USC 102 Novelty (BERT): 0.5977332778719013
- Combined Prediction Score: 0.7696022202579186
- Mean Citation Score: 431.71220199999993
- Max Citation Score: 587.7082
- Similarity Product: 434.7848660435319

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test