PATENT CLAIM ANALYSIS

Application Number: 15908659
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-12
Patent Classification: ["424", "178100"]

Abstract:
Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates may include a biologically-active molecule. Such conjugates may comprise a chimeric receptor to direct T cells to respond to ROR1 cancer cells, Methods to use the scFV conjugates to target cells expressing ROR1 for therapeutic and diagnostic purposes are also provided.

Claim (Index 52):
A method of making a chimeric antigen receptor T cell comprising transducing a T cell with an expression construct comprising a nucleic acid encoding a chimeric antigen receptor, wherein said chimeric antigen receptor comprises a single-chain variable fragment (scFv) comprising:\n (a) a light chain variable region that comprises a CDR L1 corresponding to amino acid position 27-32 of SEQ ID NO: 2, a CDR L2 corresponding to amino acid position 50-52 of SEQ ID NO: 2, and a CDR L3 corresponding to amino acid position 89-97 of SEQ ID NO: 2; and (b) a heavy chain variable region that comprises a CDR H1 corresponding to amino acid position 151-158 of SEQ ID NO: 2, a CDR H2 corresponding to amino acid position 176-182 of SEQ ID NO: 2, and a CDR H3 corresponding to amino acid position 223-233 of SEQ ID NO: 2, wherein said scFv is capable of binding receptor tyrosine kinase-like orphan receptor 1 (ROR1).

Metadata:
- Claim Count in Document: 23.0
- Percentile: 88.0
- Lexical Diversity: 1.39216
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14973486', '13703864', '15619119', '12545731', '14422519']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7546119995572289
- 35 USC 102 Novelty (BERT): 0.6134347143414485
- Combined Prediction Score: 0.7404942710356509
- Mean Citation Score: 450.89352
- Max Citation Score: 613.11084
- Similarity Product: 468.41262447076326

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test