PATENT CLAIM ANALYSIS

Application Number: 15859805
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["435", "006100"]

Abstract:
The present disclosure provides systems, devices, and methods for purifying microorganism nucleic acid from a host sample, such as a whole blood sample from a human. In certain embodiments, devices and systems with multiple filters are employed and provide for the selective removal of blood cells and host nucleic acids from a sample in order to enrich for microorganism nucleic acid.

Claim (Index 9):
A method of purifying a sample comprising:\n a) providing:\n i) a sample comprising human cells and suspected of containing pathogens comprising pathogen nucleic acid; and \n ii) a multi-stage purification device comprising:\n A) a sample containment vessel, wherein said sample containment vessel comprises a proximal end and a distal end, \n B) a first filter comprising pores approximately 10-20 \u03bcm in size, positioned inside said vessel; \n C) a second filter comprising pores approximately 1-2 \u03bcm in size, positioned inside said vessel and distal to said first filter; and \n D) a third filter comprising pores approximately 0.1 \u03bcm in size, positioned inside said vessel distal to said first and second filters; \n wherein said first, second, and third filters are further positioned inside said sample containment vessel such that fluid passing from said proximal end to said distal end of said sample containment vessel passes through said first, second, and third filters; and \n \n b) pouring said sample into said proximal end of said sample containment vessel and treating said multi-stage purification device such that a purified sample is collected in, or eluted from, said distal end of said sample containment vessel, wherein said purified sample is free or at least 99% free of said human cells and comprises at least a portion of said pathogen nucleic acid if originally present in said sample.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 86.0
- Lexical Diversity: 1.55814
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13724527', '14237328', '12674403', '13046186', '13389139']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.47991578996315
- 35 USC 102 Novelty (BERT): 0.5519889152390421
- Combined Prediction Score: 0.4871231024907392
- Mean Citation Score: 209.675806
- Max Citation Score: 422.98712
- Similarity Product: 278.9094315841293

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test