PATENT CLAIM ANALYSIS

Application Number: 15950863
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["506", "007000"]

Abstract:
Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients.

Claim (Index 5):
The method of  claim 4 , wherein mate pairs of the mate-paired library comprises two genomic tags that are co-linear but not contiguous in a segment of the tumor DNA.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.32258
- Patent Class: 506.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14790833', '13339986', '14526344', '14466208', '11639712']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5785491392664446
- 35 USC 102 Novelty (BERT): 0.5710101962137248
- Combined Prediction Score: 0.5777952449611726
- Mean Citation Score: 285.68419
- Max Citation Score: 503.7
- Similarity Product: 333.0204336225986

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test