PATENT CLAIM ANALYSIS

Application Number: 16175758
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["800", "021000"]

Abstract:
A genetically modified mouse is provided that comprises a conditional Acvr1 allele that comprises a mutated exon that, upon induction, converts to a mutant exon phenotype, wherein the mutant exon phenotype includes ectopic bone formation. Mice comprising a mutant Acvr1 exon 5 in antisense orientation, flanked by site-specific recombinase recognition sites, are provided, wherein the mice further comprise a site-specific recombinase that recognizes the site-specific recombinase recognitions sites, wherein the recombinase is induced upon exposure of the mouse to tamoxifen. Upon exposure to tamoxifen, the recombinase is expressed and acts on the RRS-flanked mutant exon 5 and places the mutant exon 5 in sense orientation and deletes the wild-type exon.

Claim (Index 31):
A progeny mouse whose genome comprises a recombined modified mouse Activin A receptor type 1 (Acvr1) gene, wherein the progeny mouse is produced by a method comprising breeding a first mouse whose genome comprises a modified mouse Acvr1 gene with a second mouse comprising a gene encoding an inducible recombinase, wherein the modified mouse Acvr1 gene comprises\n i) a human Acvr1 gene exon 5, in sense orientation and encoding glutamic acid at the first codon instead of aspartic acid, flanked upstream and downstream by a first pair of recombination recognition sites, and ii) a mouse Acvr1 gene exon 5, in antisense orientation and encoding an R206H variation, flanked upstream and downstream by a second pair of recombination recognition sites that are different than the first pair of recombination recognition sites, wherein the first and second recombination recognition sites are oriented so that a recombinase can invert the mouse Acvr1 gene exon 5 into sense orientation and delete the human Acvr1 gene exon 5, thereby producing a recombined modified mouse Acvr1 gene encoding the R206H variation, and allowing the recombined modified mouse Acvr1 gene to be expressed resulting in ectopic bone formation; then, inducing the inducible recombinase in the progeny mouse such that the inducible recombinase inverts the mouse Acvr1 gene exon 5 into sense orientation and deletes the human Acvr1 gene exon 5, thereby producing the recombined modified mouse Acvr1 gene encoding the R206H variation, and thereby allowing the recombined modified mouse Acvr1 gene to be expressed resulting in ectopic bone formation.

Metadata:
- Claim Count in Document: 75.0
- Percentile: 97.0
- Lexical Diversity: 2.01667
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14207320', '15983743', '16175762', '15336603', '09853033']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8174966717049996
- 35 USC 102 Novelty (BERT): 0.7938627501771395
- Combined Prediction Score: 0.8151332795522137
- Mean Citation Score: 955.718586
- Max Citation Score: 1115.7084
- Similarity Product: 1006.8739331241134

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test