PATENT CLAIM ANALYSIS

Application Number: 16119027
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["424", "400000"]

Abstract:
Provided are methods relating to compositions that include a CDP-camptothecin or camptothecin derivative conjugate, e.g., CRLX101.

Claim (Index 1):
A method of treating rectal cancer in a subject, the method comprising:\n providing an initial administration of a cyclodextrin (CDP)-camptothecin conjugate, particle or composition to said subject at a dosage of 6 mg/m 2 , 7 mg/m 2 , 8 mg/m 2 , 9 mg/m 2 , 10 mg/m 2 , 11 mg/m 2 , 12 mg/m 2 , 13 mg/m 2 , 14 mg/m 2 , 15 mg/m 2 , 16 mg/m 2 , 17 mg/m 2  or 18 mg/m 2  (wherein said dosage is expressed in mg of drug, as opposed to mg of conjugate), providing one or more subsequent administrations of said CDP-camptothecin conjugate, particle or composition at a dosage of 6 mg/m 2 , 7 mg/m 2 , 8 mg/m 2 , 9 mg/m 2 , 10 mg/m 2 , 11 mg/m 2 , 12 mg/m 2 , 13 mg/m 2 , 14 mg/m 2 , 15 mg/m 2 , 16 mg/m 2 , 17 mg/m 2  or 18 mg/m 2 , wherein each subsequent administration is provided, independently, between 12, 13, 14, 15 or 16 days, after the previous administration, providing multiple radiation treatments, wherein an initial radiation treatment is administered with the administration of said CDP-camptothecin conjugate, particle or composition of said CDP-camptothecin conjugate, particle or composition, and said radiation treatments are administered daily five days a week on weekdays for at least 25 to 35 days; and administering multiple doses of a pyrimidine analogue, to thereby treat the rectal cancer.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 96.0
- Lexical Diversity: 1.05556
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15312139', '14885174', '14955469', '15069208', '15723981']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6683447264918477
- 35 USC 102 Novelty (BERT): 0.489580665039092
- Combined Prediction Score: 0.6504683203465722
- Mean Citation Score: 200.970564
- Max Citation Score: 204.61128
- Similarity Product: 143.845512386384

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test