PATENT CLAIM ANALYSIS

Application Number: 16218341
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["540", "602000"]

Abstract:
Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.

Claim (Index 1):
A method of decreasing c-Myc expression in a cell, comprising contacting the cell with an effective amount of a compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein:\n A is a 6 membered aryl ring; \n C is a 6-membered aryl ring; \n each R 1  is independently selected from hydrogen or optionally-substituted lower alkyl; \n a is 0, 1, or 2; \n R 2  is selected from hydroxyl or halogen; \n R 8  and R 9  together with the linking nitrogen atom form a 4 to 7 membered optionally-substituted N-hetero- mono- or bi-cyclic ring with one or two hetero atoms independently selected from nitrogen and oxygen; \n each R 3  is independently selected from halogen, lower haloalkyl, or optionally-substituted lower alkyl; \n b is 0 to 4; \n R 4  is selected from halogen, lower haloalkyl, or optionally-substituted lower alkyl; \n each R 5  is independently selected from halogen, lower haloalkyl, or optionally-substituted lower alkyl; \n d is 0, 1, or 2; \n R 6  is selected from methyl, trifluoromethyl, or phenyl; \n Z is selected from nitrogen or oxygen; \n if Z is nitrogen, R 7  is selected from hydrogen, hydroxyl, halogen, lower haloalkyl, or optionally-substituted lower alkyl, and if Z is oxygen, R 7  is not present; and \n wherein each substituted lower alkyl and substituted N-hetero- mono- or bi-cyclic ring is independently selected from a lower alkyl or N-hetero- mono- or bi-cyclic ring wherein one or more hydrogen atoms are replaced with C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, hydroxyl, oxo, C 1-6 alkoxy, aryloxy, C 1-6 alkoxyaryl, C 1-6 alkylhalo, C 1-6 alkoxyhalo, carboxyl, cyano, nitro, amino, acyl, amido, aminoacyl, mercapto, alkylthio, thioxo, sulfates, sulfonates, sulfinyl, sulfonyl, sulfonylamido, aryl, arC 1-6 alkyl, heterocyclyl, heteroaryl, or halogen.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 98.0
- Lexical Diversity: 1.5625
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15541676', '13513819', '13991321', '14156314', '14571647']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6762141759789418
- 35 USC 102 Novelty (BERT): 0.5787939600160903
- Combined Prediction Score: 0.6664721543826567
- Mean Citation Score: 316.660638
- Max Citation Score: 528.7619599999998
- Similarity Product: 343.56783950138794

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test