PATENT CLAIM ANALYSIS

Application Number: 16109477
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["546", "046000"]

Abstract:
Methods are provided for efficient preparation of hydromorphone or hydrocodone by redox isomerization of morphine or codeine allylic alcohols, respectively, using transition metal aminophosphine catalysts formed in situ.

Claim (Index 64):
A method for preparing a pharmaceutically acceptable salt of hydrocodone or a solvate thereof, or a pharmaceutically acceptable salt of hydromorphone or a solvate thereof, comprising\n catalytically converting codeine into hydrocodone or morphine into hydromorphone comprising exposing the codeine or morphine to at least one transition metal complex catalyst to form a reaction mixture comprising the hydrocodone or hydromorphone; removing the transition metal catalyst or a degradant thereof from the reaction mixture to provide hydrocodone base or hydromorphone base; adding a pharmaceutically acceptable acid to the hydrocodone base or hydromorphone base to provide a pharmaceutically acceptable salt of the hydrocodone, or pharmaceutically acceptable salt of the hydromorphone; isolating a precipitate of the pharmaceutically acceptable salt of the hydrocodone or solvate thereof, or pharmaceutically acceptable salt of the hydromorphone or a solvate thereof; and drying the precipitate of the pharmaceutically acceptable salt of the hydrocodone or solvate thereof, or the pharmaceutically acceptable salt of the hydromorphone or solvate thereof, under humidified compressed air, humidified nitrogen, or humidified argon.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 96.0
- Lexical Diversity: 1.10714
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15644266', '11671962', '10495503', '13093892', '12994923']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7693982964969754
- 35 USC 102 Novelty (BERT): 0.5685194257556353
- Combined Prediction Score: 0.7493104094228416
- Mean Citation Score: 298.219792
- Max Citation Score: 509.0364
- Similarity Product: 359.3263136483431

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test