PATENT CLAIM ANALYSIS

Application Number: 15940152
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "457000"]

Abstract:
A compound can be a fluorescent taxane derivative having a structure of Formula 1, salt, stereoisomer, tautomer, polymorph, or solvate thereof. Formula 1 can be defined as: L, L-NH, or L-NH—C═O is a linker; and R is a substituent, where —OH, —O − , —NH 2 , and NH—CH 3  are examples. Examples of linkers can include glycine, beta-alanine, gamma-aminobutyric acid (GABA). Pharmaceutical compositions can include the compound and a pharmaceutically acceptable carrier, and may be configured for intravenous injection. The fluorescent taxane derivative can be used to treat cancer and non-cancer diseases. The fluorescent taxane derivative can be used to monitor cellular efflux and determine whether a cell will efflux paclitaxel.

Claim (Index 2):
The compound of  claim 1 , comprising:\n a fluorescent taxane derivative having a structure of Formula 1, salt, stereoisomer, tautomer, polymorph, or solvate thereof; wherein: L, L-NH, or L-NH\u2014C\u2550O is the linker; R is selected from: (a) \u2014NH 2 , \u2014NH-alkyl, \u2014N(alkyl) 2 , \u2014NH 2 \u2014R1, \u2014N(R1) 2  or \u2014NR1R2, or combination thereof; (b) \u2014C(O)R1a, \u2014C(O)CH(NR1bR1c)R1a, \u2014C(O)CH(N(R1c)C(O)R1b)R1a, \u2014C(O)CH(N(R1c)C(O)OR1b)R1a, \u2014C(O)CH(N(R1c)C(O)NR1bR1d)R1a, \u2014C(O)OR1a, \u2014C(O)NR1bR1c, \u2014C(NR1a)NR1bR1c, \u2014P(O)(OR1a)R1d, \u2014CH2P(O)(OR1a)R1d, \u2014S(O)R1a, \u2014S(O)2R1a, \u2014S(O)NR1bR1c, or \u2014S(O)2NR1bR1c; (c) C 1 -C 24  alkyl, C 2 -C 24  alkenyl, C 2 -C 24  alkynyl, C 3 -C 20  cycloalkyl, C 5 -C 20  aryl, C 5 -C 20  polyaryl, C 6 -C 24  alkaryl, C 6 -C 24  aralkyl, heteroaryl, heterocyclyl, hydrogen, halo, oxygen anion, hydroxy anion, hydroxyl, sulfhydryl, C 1 -C 24  alkoxy, C 2 -C 24  alkenyloxy, C 2 -C 24  alkynyloxy, C 5 -C 20  aryloxy, acyl, C 2 -C 24  alkylcarbonyl, C 6 -C 20  arylcarbonyl, acyloxy, C 2 -C 24  alkoxycarbonyl, C 6 -C 20  aryloxycarbonyl, halocarbonyl, C 2 -C 24  alkylcarbonato, C 6 -C 20  arylcarbonato, carboxy, carboxylato, carbamoyl, mono-(C 1 -C 24  alkyl)-substituted carbamoyl, di-(C 1 -C 24  alkyl)-substituted carbamoyl, mono-substituted arylcarbamoyl, thiocarbamoyl, carbamido, cyano, isocyano, cyanato, isocyanato, isothiocyanato, azido, formyl, thioformyl, amino, mono- and di-(C 1 -C 24  alkyl)-substituted amino, mono- and di-(C 5 -C 20  aryl)-substituted amino, C 2 -C 24  alkylamido, C 6 -C 20  arylamido, imino, alkylimino, arylimino, nitro, nitroso, sulfo, sulfonato, C 1 -C 24  alkylsulfanyl, arylsulfanyl, C 1 -C 24  alkylsulfinyl, C 5 -C 20  arylsulfinyl, C 1 -C 24  alkylsulfonyl, C 5 -C 20  arylsulfonyl, phosphono, phosphonato, phosphinato, phospho, or phosphino, or combinations thereof; and (d) combinations thereof; wherein the R group is optionally substituted by a substituent Q, which substituent Q is defined as R; and wherein R1, R2, R1a, R1b, R1c, or R1d are each independently as defined for R or independently hydrogen.

Metadata:
- Claim Count in Document: 33.0
- Percentile: 90.0
- Lexical Diversity: 1.675
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13202426', '14873776', '14971153', '13558886', '14953860']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7120988065021632
- 35 USC 102 Novelty (BERT): 0.4985707593426375
- Combined Prediction Score: 0.6907460017862106
- Mean Citation Score: 216.597674
- Max Citation Score: 224.47897000000003
- Similarity Product: 164.7931660007417

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test