PATENT CLAIM ANALYSIS

Application Number: 15752896
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "210180"]

Abstract:
Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.

Claim (Index 4):
The substituted quinolone derivative, or a pharmaceutically acceptable salt or a stereoisomer thereof according to  claim 1 , characterized in having a structure as shown below: wherein, n=0-2, and W is CH 2  or O; X is optionally selected from: CH or N; R 1  is optionally selected from: hydrogen or halogen; R 2  is optionally selected from: R 9  is optionally selected from: hydrogen, C 1 -C 5  alkyl or C 3 -C 6  cycloalkyl;\n R 3  is optionally selected from: hydrogen, halogen, trifluoromethyl or C 1 -C 3  alkyl; \n R 4  is optionally selected from: hydrogen, C 1 -C 5  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 3  alkoxy, substituted or unsubstituted phenyl; \n R 5  is optionally selected from: hydrogen, \u2014(CH 2 ) r \u2014COOR 22 , \u2014(CH 2 ) r \u2014NR 23 R 24 , -L-heteroaryl or \n r, s 1 , s 2 , and s 3  in R 5  are each independently selected from 0, 1, 2 or 3; V is optionally selected from: CH or N; U is optionally selected from: O, S, CR 23 R 24  or NR 23 ; R 22  is optionally selected from: hydrogen or C 1 -C 4  alkyl; R 23  and R 24  are optionally selected from: H, C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl, \u2014NH(C 1 -C 3 alkyl), \u2014N(C 1 -C 3  alkyl)(C 1 -C 3  alkyl) or \u2014C(\u2550O)(C 1 -C 3  alkyl); L is optionally selected from: C 1 -C 3  alkyl, \u2014NR 25 \u2014, \u2014NR 25 CO\u2014, \u2014CONR 25 \u2014, \u2014O\u2014, \u2014CO\u2014, \u2014SO\u2014 or \u2014SO 2 \u2014; R 25  is selected from: C 1 -C 3  alkyl; R 6  is optionally selected from: hydrogen, halogen, C 1 -C 5  alkyl, C 2 -C 6  alkenyl, C 3 -C 6  cycloalkyl, C 4 -C 6  cycloalkenyl, C 1 -C 5  alkoxy, trifluoromethyl or trifluoromethoxy; R 7  is optionally selected from: hydrogen, C 1 -C 5  alkyl or C 3 -C 6  cycloalkyl; or R 7 , ring C and ring D constitute a fused tricycle R 10  is optionally selected from H or CH 3 ;\n and the fused tricycle has one of the following structures:

Metadata:
- Claim Count in Document: 6.0
- Percentile: 88.0
- Lexical Diversity: 1.88235
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14411515', '14207868', '13928696', '13294303', '14916177']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8312620619575416
- 35 USC 102 Novelty (BERT): 0.5575139600676605
- Combined Prediction Score: 0.8038872517685535
- Mean Citation Score: 423.024436
- Max Citation Score: 440.52917
- Similarity Product: 334.01299329089704

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test