PATENT CLAIM ANALYSIS

Application Number: 15946658
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "029000"]

Abstract:
Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

Claim (Index 98):
The compound of  claim 81 , or a salt thereof, wherein R 9  is a group of formula: wherein:\n each of R S1 , R S2a , R S2b , R S3a , R S3b , R S4a , R S4b , R S5a , and R S5b  is independently hydrogen, optionally substituted alkyl, \u2014OR SO , \u2014N(R SN ) 2 , or wherein R S2a  or R S2b  may be taken together with R S3a  or R S3b  to form an optionally substituted fused heterocyclic ring; \n each instance of R SO  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted heterocyclyl, or an oxygen protecting group; and \n each instance of R SN  is independently hydrogen, optionally substituted alkyl, or a nitrogen protecting group; or optionally two R SN  are taken with the intervening atoms to form a heterocyclic ring.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 91.0
- Lexical Diversity: 1.75
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14781719', '15558896', '15517843', '13953647', '13205112']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7597898500534931
- 35 USC 102 Novelty (BERT): 0.6338922505525673
- Combined Prediction Score: 0.7472000901034005
- Mean Citation Score: 409.020056
- Max Citation Score: 584.48474
- Similarity Product: 539.0581410394741

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test