PATENT CLAIM ANALYSIS

Application Number: 15752048
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "006110"]

Abstract:
The present invention relates to a method, in particular an in vitro method, for identifying CD56+ NK cells, comprising analyzing the methylation status of at least one CpG position in the mammalian gene region for mevalonate (diphospho) decarboxylase (MVD), wherein a demethylation or lack of methylation of said gene region is indicative for a CD56+ NK cell, when compared to a non-CD56+ NK cell. The analyses according to the invention can identify CD 56+ NK cells on an epigenetic level and distinguish them from all other cells in complex samples, such as, for example, other blood or immune cells. The present invention furthermore provides an improved method for quantifying CD56+ NK cells, in particular in complex samples. The method can be performed without a step of purifying and/or enriching cells, preferably in whole blood and/or non-trypsinized tissue.

Claim (Index 10):
A method for monitoring the level of CD56+ NK cells in a mammal, comprising performing the method according to  claim 5 , and furthermore comparing said relative amount of said cells as identified to a sample taken earlier or in parallel from the same mammal, and/or to a control sample.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 88.0
- Lexical Diversity: 1.80233
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14443223', '14353671', '14233611', '13318015', '13636556']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5957237706745363
- 35 USC 102 Novelty (BERT): 0.5341390732294651
- Combined Prediction Score: 0.5895653009300291
- Mean Citation Score: 326.372704
- Max Citation Score: 363.21844
- Similarity Product: 282.2104480017233

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test