PATENT CLAIM ANALYSIS

Application Number: 16107087
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "064000"]

Abstract:
Compounds according to Formula I are potent inhibitors of Arginase I and II activity: where R 1 , R 2 , R 3 , R 4 , D, W, X, Y, and Z are defined in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use in treating or preventing a disease or a condition associated with arginase activity.

Claim (Index 41):
A compound having the structure of the formula: wherein\n R 1  is selected from the group consisting of \u2014OH, \u2014OR a , and \u2014NR b R c ;\n R a  is selected from the group consisting of hydrogen, straight or branched chain (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 14 )aryl, (C 3 -C 14 )heterocycloalkyl-(C 1 -C 6 )alkylene-, (C 3 -C 14 )heteroaryl-(C 1 -C 6 )alkylene-, and (C 3 -C 14 )aryl(C 1 -C 6 )alkylene-; \n R b  and R c  are each independently selected from the group consisting of H, \u2014OH, straight or branched (C 1 -C 6 )alkyl, \u2014SO 2 \u2014(C 1 -C 6 )alkyl, (C 3 -C 14 )aryl-SO 2 \u2014, (C 3 -C 14 )heterocycloalkyl-(C 1 -C 6 )alkylene-, and (C 3 -C 14 )heteroaryl-(C 1 -C 6 )alkylene-; \n \n R 2  is selected from the group consisting of \u2014NH 2 , \u2014N 3 , \u2014NH[straight or branched (C 1 -C 6 ) alkyl], and \u2014NHCO[(C 1 -C 6 )alkyl]; \n R\u2032\u2033 is selected from H, \u2014OH, \u2014S(O)R d , \u2014S(O) 2 R d , (C 1 -C 8 )alkyl, (C 3 -C 14 )aryl, \u2014NH 2 , \u2014NH(C 1 -C 6 )alkyl, \u2014N[(C 1 -C 6 )alkyl] 2 , \u2014C(O)NR d R e , \u2014C(O)(C 1 -C 6 )alkyl, \u2014C(O)(C 3 -C 14 )aryl, \u2014C(O)O(C 1 -C 6 )alkyl, \u2014C(O)O(C 3 -C 14 )aryl, (C 3 -C 6 )cycloalkyl, (C 3 \u2014C 14 )heterocycloalkyl, \u2014C(O)(C 3 -C 14 )heterocycloalkyl, (C 3 -C 14 )heteroaryl, (C 3 -C 14 )aryl-(C 1 -C 6 )alkylene-, \u2014C(O)(C 3 -C 14 )aryl-(C 1 -C 6 )alkylene, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkylene-, (C 3 -C 14 )heteroaryl-(C 1 -C 6 )alkylene-, and (C 3 -C 14 )heterocycle-(C 1 -C 6 )alkylene-; \n R\u2033\u2033 is selected from H or \n R 3  and R 4  are each independently selected from straight or branched (C 1 -C 6 )alkyl and C(O)\u2014R 5 , wherein R 5  is selected from (C 1 -C 8 )alkyl, (C 3 -C 14 )aryl, \u2014NH(C 1 -C 6 )alkyl, \u2014N[(C 1 -C 6 )alkyl] 2 , (C 3 -C 6 )cycloalkyl, (C 3 -C 14 )heterocycloalkyl, (C 3 -C 14 )heteroaryl, (C 3 -C 14 )aryl-(C 1 -C 6 )alkylene-, (C 3 -C 6 )cycloalkyl-(C 1 -C 6 )alkylene-, (C 3 -C 14 )heteroaryl-(C 1 -C 6 )alkylene-, and (C 3 -C 14 )heterocycle-(C 1 -C 6 )alkylene-; or R 3  and R 4  together with the boron atom to which they are bound form a 5- or 6-membered ring that is fully saturated, or partially saturated; and  is a single bond or double bond; wherein any alkyl, alkylene, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl is optionally substituted with one or more members selected from halogen, oxo, \u2014COOH, \u2014CN, \u2014NO 2 , \u2014OH, \u2014NR d R e , \u2014NR g S(O) 2 R h , (C 1 -C 6 )alkoxy, (C 3 -C 14 )aryl, (C 1 -C 6 )haloalkyl and (C 3 -C 14 )aryloxy; and wherein R d , R e , R g , and R h  are each independently selected from H, straight or branched (C 1 -C 6 )alkyl, (C 3 -C 14 )aryl-(C 1 -C 6 )alkylene-, (C 3 -C 14 )aryl, (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 )aminoalkyl, H 2 N(C 1 -C 6 )alkylene-, (C 3 -C 6 )cycloalkyl, (C 3 -C 14 )heterocycloalkyl, (C 3 -C 14 )heteroaryl, (C 3 -C 14 )aryl-(C 1 -C 6 )alkylene-, and (C 3 -C 6 )aryl-(C 3 -C 14 )-cycloalkylene-, or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 96.0
- Lexical Diversity: 1.44
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15207902', '13276806', '14614115', '14471244', '15972996']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8114806318448888
- 35 USC 102 Novelty (BERT): 0.5640024823373697
- Combined Prediction Score: 0.786732816894137
- Mean Citation Score: 401.323864
- Max Citation Score: 423.62912
- Similarity Product: 412.7552961489487

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test