PATENT CLAIM ANALYSIS

Application Number: 16067115
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["530", "308000"]

Abstract:
A method for preparing Sermaglutide. Amino acid protected by Fmoc-Lys(Alloc)-OH is used as a raw material, and protection is carried out by selecting Pd(PPh3)4. In one aspect, the operation process is simple, one or two times of elimination reactions are required only, each time lasts 10 min to 30 min, and no side reaction occurs, and the operation process is safe, so that the preparation method is suitable for expanding production. The risk of His racemization can be reduced to the greatest extent in the process by using Boc-His(Boc)-OH.DCHA and Boc-His(Trt)-OH as raw materials. The synthesis efficiency is improved by performing coupling by using special segments.

Claim (Index 7):
The preparation method according to  claim 2 , wherein in the fragmental synthesis of the Lys 26  side chain, the recrystallizing is performed with one or a mixture of two or more of Et 2 O, CH 2 Cl 2 , CHCl 3 , MeOH, CH 3 CN, THF, EtOAc, EtOH, Toluene, Hexane, or Acetone.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 94.0
- Lexical Diversity: 1.54023
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15738876', '14371004', '10542230', '14344660', '15523384']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7330277860375021
- 35 USC 102 Novelty (BERT): 0.5224278199340304
- Combined Prediction Score: 0.7119677894271549
- Mean Citation Score: 323.536896
- Max Citation Score: 328.1378200000001
- Similarity Product: 220.30436225269565

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test