PATENT CLAIM ANALYSIS

Application Number: 15860174
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["424", "165100"]

Abstract:
The present invention provides antibodies that bind to  Staphylococcus aureus  Hemolysin A toxin, and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Hemolysin A. The antibodies of the invention are useful for inhibiting or neutralizing Hemolysin A activity, thus providing a means of preventing or treating a Hemolysin A-related disease or disorder such as  S. aureus  infection. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of a  S. aureus  infection.

Claim (Index 1):
An isolated human monoclonal antibody or antigen-binding fragment thereof that binds specifically to Hemolysin A, wherein the antibody or antigen-binding fragment exhibits one or more properties selected from the group consisting of:\n (a) binds to wild type Hemolysin A at 37\u00b0 C. with a binding dissociation equilibrium constant (K D ) of less than about 80 nM as measured by surface plasmon resonance; (b) binds to wild type Hemolysin A at 37\u00b0 C. with a dissociative half-life (t\u00bd) of greater than about 0.5 minutes as measured by surface plasmon resonance; (c) binds to wild type Hemolysin A at 25\u00b0 C. with a K D  of less than about 30 nM as measured by surface plasmon resonance; (d) binds to wild type Hemolysin A at 25\u00b0 C. with a t\u00bd of greater than about 1.5 minutes as measured by surface plasmon resonance; (e) binds to a modified Hemolysin A at 37\u00b0 C. with a binding dissociation equilibrium constant (K D ) of less than about 20 nM as measured by surface plasmon resonance; (f) binds to a modified Hemolysin A at 37\u00b0 C. with a dissociative half-life (t\u00bd) of greater than about 0.5 minutes as measured by surface plasmon resonance; (g) binds to a modified Hemolysin A at 25\u00b0 C. with a K D  of less than about 10 nM as measured by surface plasmon resonance; (h) binds to a modified Hemolysin A at 25\u00b0 C. with a t\u00bd of greater than about 1.5 minutes as measured by surface plasmon resonance; (i) inhibits hemolysin A-mediated rabbit red blood cell hemolysis by a  S. aureus  strain selected from the group consisting of GA201; CA-127; TCH1516; GA229; 8:03; 27-05; 94:1013; and 7031; and (j) blocks interaction between hemolysin A and ADAM10.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 86.0
- Lexical Diversity: 1.85185
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15289032', '15651387', '15005334', '14447444', '15637867']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7784389060991548
- 35 USC 102 Novelty (BERT): 0.5555038290457004
- Combined Prediction Score: 0.7561453983938093
- Mean Citation Score: 406.249138
- Max Citation Score: 415.6375
- Similarity Product: 356.5346926674247

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test