PATENT CLAIM ANALYSIS

Application Number: 16144717
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["544", "057000"]

Abstract:
Provided herein are α-aminophosphonates and methods for making same. Also provided are N-heterocyclic phosphines (NHPs) useful in metal-free phosphorus-carbon bond forming reactions such as, for example, in the preparation of α-aminophosphonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Claim (Index 12):
A method of making a compound having a structure represented by a formula: wherein Q is selected from O, S, C\u2550O, S\u2550O, SO 2 , and NR 1 ; wherein each of X A  and X B  is independently selected from NR 1 , O, and S;\n wherein each occurrence of R 1 , when present, is independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-C10 aryl, \u2014(C1-C3 alkyl)(C6-C10 aryl), and 4-10 membered heteroaryl, and wherein each occurrence of R 1 , when present, is independently substituted with 0, 1, 2, 3, or 4 independently selected R 5  groups;\n wherein each occurrence of R 5 , when present, is independently selected from halogen, \u2014NO 2 , \u2014CN, \u2014OH, \u2014SH, \u2014NH 2 , C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C3 haloalkyl, C1-C3 cyanoalkyl, C1-C3 hydroxyalkyl, C1-C3 haloalkoxy, C1-C3 alkoxy, C1-C3 thioalkyl, C1-C3 alkyl(C1-C3 alkoxy), C1-C3 alkylamino, (C1-C3)(C1-C3) dialkylamino, C3-C7 cycloalkyl, optionally substituted C6-C10 aryl, \u2014(C\u2550O)(C1-C3 alkyl), \u2014(S\u2550O)(C1-C3 alkyl), \u2014SO 2 (C1-C3 alkyl), \u2014CO 2 R 11 , \u2014(C\u2550O)NR 12a R 12b , \u2014SO 2 NR 12a R 12b , \u2014O(C\u2550O)NR 12a R 12b , NHSO 2 NR 2a R 12b , and \u2014NH(C\u2550O)NR 2a R 12b ;\n wherein each occurrence of R 11 , when present, is independently selected from hydrogen and C1-C4 alkyl; \n wherein each occurrence of R 12a  and R 12b , when present, is independently selected from hydrogen and C1-C3 alkyl; \n \n \n wherein each of Rx and R Y  is independently selected from hydrogen, C1-C8 alkyl, C6-C10 aryloxy, C6-C10 aryl, and 4-10 membered heteroaryl, or wherein each of Rx and R Y  are optionally covalently bonded together and, together with the intermediate atoms, comprise a 5- to 7-membered cycloalkyl, a 5- to 7-membered heterocycloalkyl, a 5- to 7-membered aryl, or a 5- to 7-membered heteroaryl and are substituted with 0, 1, 2, 3, or 4 independently selected R 5  groups; wherein R 6  is selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-C10 aryl, \u2014(C1-C3 alkyl)(C6-C10 aryl), and 4-10 membered heteroaryl, and substituted with 0, 1, 2, 3, or 4 independently selected R 5  groups; and wherein each of R 10a  and R 10b  is independently selected from hydrogen and C1-C4 alkyl, or a salt thereof, the method comprising the step of reacting an aldehyde having a structure represented by a formula: or a salt thereof, with a heterocycloalkane having a structure represented by a formula: or a salt thereof, in the presence of a reagent having a structure represented by a formula: wherein m is selected from 0 and 1; wherein p is selected from 0, 1, 2, 3, 4, and 5; wherein Z is selected from C\u2550O, C\u2550S, S\u2550O, SO 2 , and a structure represented by a formula: wherein each of R 2a  and R 2b  is independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-C10 aryl, \u2014(C1-C3 alkyl)(C6-C10 aryl), and 4-10 membered heteroaryl, and substituted with 0, 1, 2, 3, or 4 independently selected R 5  groups; wherein each of R 3a  and R 3b , when present, is independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-C10 aryl, \u2014(C1-C3 alkyl)(C6-C10 aryl), and 4-10 membered heteroaryl, and wherein each of R 3a  and R 3b  is independently substituted with 0, 1, 2, 3, or 4 independently selected R 5  groups; and wherein R 4  is selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-C10 aryl, and 4-10 membered heteroaryl, and \u2014(C1-C3 alkyl)(C6-C10 aryl), and substituted with 0, 1, 2, 3, or 4 independently selected R 5  groups, or a salt thereof.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 97.0
- Lexical Diversity: 1.35417
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15436608', '15505052', '14228184', '13436963', '14433580']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7822470740044277
- 35 USC 102 Novelty (BERT): 0.6712261556537066
- Combined Prediction Score: 0.7711449821693557
- Mean Citation Score: 516.9776079999998
- Max Citation Score: 676.9578
- Similarity Product: 648.1088019194126

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test