PATENT CLAIM ANALYSIS

Application Number: 15770737
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "356000"]

Abstract:
The present specification provides methods of treating nervous system disorders with a thyroid hormone neutral dose of a RXR agonist to promote remyelination or neuroprotection or both and thereby maintain or regenerate healthy axons and neurons.

Claim (Index 1):
A method of treating a nervous system disorder in a subject comprising:\n (a) determining the subject's baseline plasma T4 levels; (b) administering a dose of a RXR agonist to a patient daily for a period of time; (c) determining the subject's plasma T4 levels, (d) increasing the dose of the RXR agonist if the plasma T4 levels are substantially unchanged, or (e) decreasing the dose of the RXR agonist if the plasma T4 levels have substantially decreased; and (f) repeating steps (b) through (d) until a dose of the RXR agonist is established which is thyroid hormone neutral; and (g) continuing to administer the dose of step (e) to the subject to treat the nervous system disorder; wherein the thyroid hormone neutral dose of RXR agonist results in an improved efficacy in the individual as compared to a dose of the RXR agonist which causes a substantial decrease in plasma T4 levels.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.15625
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15812821', '15339752', '15339762', '14507730', '10477876']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8505923378577829
- 35 USC 102 Novelty (BERT): 0.5953552416554366
- Combined Prediction Score: 0.8250686282375482
- Mean Citation Score: 525.456226
- Max Citation Score: 623.54266
- Similarity Product: 384.072023323158

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test