PATENT CLAIM ANALYSIS

Application Number: 16060056
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "210160"]

Abstract:
Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated modulate the NMDA receptor.

Claim (Index 19):
A compound represented by: and pharmaceutically acceptable salts, stereoisomers and prodrugs thereof, wherein: R 1  and R 2  are each independently selected from the group consisting of hydrogen, C 1-4  alkyl, C 1-4 alkoxy, and C 1-4  alkylcarbonyl or R 1  and R 2 , together with the nitrogen to which they are attached, form a 3-7 membered monocyclic, bridged bicyclic, fused bicyclic or spirocyclic heterocyclic ring which may have an additional heteroatom selected from O, S, or N; and wherein the 4-6 membered monocyclic, bridged bicyclic, fused bicyclic or spirocyclic heterocyclic ring may optionally be substituted by one, two or more substituents each selected from the group consisting of: phenyl (optionally substituted by one, two or three halogens), C 3 -C 6 cycloalkyl (optionally substituted by one, two or three halogens), C 1-6 alkoxy (optionally substituted by one, two or three halogens), and C 1-6 alkyl (optionally substituted by one, two or three halogens), and on a carbon not bound to the nitrogen, by one, two or more substituents each selected from the group consisting of halogen, cyano, oxo, NR a R b  and hydroxyl; and wherein if said 4-6 membered monocyclic, bridged bicyclic, fused bicyclic or spirocyclic heterocyclic ring contains a \u2014NH moiety that nitrogen may be optionally substituted by a substituent selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 alkyl-S(O) 2 \u2014, C 1-6 alkylcarbonyl-, and C 1-6 alkoxycarbonyl-; R 3  is selected from the group consisting of phenyl, naphthyl, heteroaryl, heterocyclyl and C 3-6 cycloalkyl, wherein R 3  is optionally substituted with one, two or three substituents each independently selected from the group consisting of C 1-6 alkyl, halogen, hydroxyl, cyano, C 1-4 alkoxy, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkyl-S(O) 2 \u2014, C 1-6 alkylcarbonyl, R a R b N\u2014SO 2 \u2014, NR a R b , C(O)OH, C 1-4 alkoxycarbonyl, and NR a R b carbonyl; wherein C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkyl-S(O) 2 \u2014, and C 1-6 alkylcarbonyl may be optionally substituted by one or more substituents each independently selected from the group consisting of halogen, hydroxyl, cyano, and NR a R b ; R 6  is independently selected for each occurrence from the group consisting of hydrogen, C 1-6  alkyl, C 1-6 alkoxy, halogen, cyano, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, heteroaryl, phenyl, \u2014C(\u2550NH)\u2014NR a R c , C(\u2550N\u2014OH)\u2014H, C(\u2550N\u2014OH)\u2014C 1-6 alkyl, \u2014NR a R b , C(O)OH, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, NR a R b carbonyl-, and R a R b N\u2014SO 2 \u2014; wherein phenyl and heteroaryl are optionally substituted by one or more substituents each selected from the group consisting of halogen, C 1-4  alkyl (optionally substituted by halogen), cyano, C 1-4  alkoxy, \u2014NR a R b , \u2550NR a , \u2014C(\u2550NH)\u2014NR a R c , and R a R b N\u2014SO 2 ); and wherein C 1-6  alkyl, C 1-6 alkyoxy, C 2-6 alkenyl, C 2-6 alkynyl, and C 3-6 cycloalkyl are each optionally substituted by one or more substituents each selected from the group consisting of hydroxyl, cyano, C 1-4 alkoxy, halogen, NR a R b , \u2550NR a , \u2014C(\u2550NH)\u2014NR a R c , cyano, and R a R b N\u2014SO 2 \u2014, R 66  and R 67  are each independently selected from the group consisting of halogen, C 1-4  alkyl (optionally substituted by one, two, three substituents selected from halogen, hydroxyl, cyano and NR a R b ); and R 7  is selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkynyl, C 3-6 cycloalkyl, heterocyclyl, heteroaryl, and phenyl; wherein C 1-6 alkyl, C 2-6 alkenyl, and C 3-6 cycloalkyl may optionally be substituted by one or more substituents each selected from the group consisting of halogen, hydroxyl, C 1-4  alkoxy (optionally substituted by halogen or \u2014Si(R s ) 0-3  (wherein R s  is H or C 1-6 alkyl)), cyano, \u2014Si(R s ) 0-3  (wherein R s  is H or C 1-6 alkyl), \u2014O\u2014Si(R s ) 0-3  (wherein R s  is H or C 1-6 alkyl), and NR a R b ; R c  is selected from the group consisting of hydrogen, C 1-3 alkyl, and hydroxyl; R a  and R b  are independently selected, for each occurrence, from the group consisting of hydrogen, hydroxyl, and C 1-3 alkyl; wherein C 1-3 alkyl may optionally be substituted by one or more substituents selected from the group consisting of fluorine, cyano, oxo and hydroxyl; or R a  and R b , together with the nitrogen to which they are attached, form a 4-6 membered heterocyclic ring which may have an additional heteroatom selected from O, S, or N.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 94.0
- Lexical Diversity: 1.48387
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13670937', '13671129', '15080351', '15506592', '12492180']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8446946033307425
- 35 USC 102 Novelty (BERT): 0.5450283319199197
- Combined Prediction Score: 0.8147279761896603
- Mean Citation Score: 391.743624
- Max Citation Score: 395.86792
- Similarity Product: 318.45721270210737

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test