PATENT CLAIM ANALYSIS

Application Number: 16120170
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["544", "324000"]

Abstract:
A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Claim (Index 49):
The method as claimed in  claim 32 , wherein the compound is selected from\n 4-N-cyclohexyl-6-phenylpyrimidine-2,4-diamine; 4-N-ethyl-6-phenylpyrimidine-2,4-diamine; 4-N-(3-ethoxypropyl)-6-phenylpyrimidine-2,4-diamine; 6-phenyl-4-N-propylpyrimidine-2,4-diamine; 6-(4-methanesulfonylphenyl)-4-N-propylpyrimidine-2,4-diamine; 4-N-(cyclopropylmethyl)-6-phenylpyrimidine-2,4-diamine; 4-N-(oxan-4-yl)-6-phenylpyrimidine-2,4-diamine; 4-N-(furan-2-ylmethyl)-6-phenylpyrimidine-2,4-diamine; 4-N-(pentan-3-yl)-6-phenylpyrimidine-2,4-diamine; 6-phenyl-4-N-(propan-2-yl)pyrimidine-2,4-diamine; 4-N-benzyl-6-phenylpyrimidine-2,4-diamine; 4-N-[2-(morpholin-4-yl)ethyl]-6-phenylpyrimidine-2,4-diamine; 6-(4-chlorophenyl)-4-N-cyclopropylpyrimidine-2,4-diamine; 4-(N-tert-butyl)-6-(4-chlorophenyl)pyrimidine-2,4-diamine; 6-(4-chlorophenyl)-4-N-(oxan-4-yl)pyrimidine-2,4-diamine; 4-N-cyclopropyl-6-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 4-N-tert-butyl-6-(4-methoxyphenyl)pyrimidine-2,4-diamine; 4-N-cyclopropyl-6-(4-methoxyphenyl)pyrimidine-2,4-diamine; 6-(3-chlorophenyl)-4-N-cyclopropylpyrimidine-2,4-diamine; 4-N-tert-butyl-6-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 6-(3-chlorophenyl)-4-N-(oxan-4-yl)pyrimidine-2,4-diamine; 4-N-tert-butyl-6-(3-chlorophenyl)pyrimidine-2,4-diamine; 4-N-methyl-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-(2,2,2-trifluoroethyl)pyrimidine-2,4-diamine; 6-(3-chlorophenyl)-4-N-(2,2,2-trifluoroethyl)pyrimidine-2,4-diamine; 6-[1-(benzenesulfonyl)-1H-indol-3-yl]-4-N-methylpyrimidine-2,4-diamine; 4-N-cyclopropyl-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 6-[1-(benzenesulfonyl)-1H-indol-3-yl]-4-N-cyclopropylpyrimidine-2,4-diamine; 6-[1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-methylpyrimidine-2,4-diamine; 6-[1-(benzenesulfonyl)-1H-indol-4-yl]-4-N-methylpyrimidine-2,4-diamine; 6-[1-(benzenesulfonyl)-1H-indol-5-yl]-4-N-methylpyrimidine-2,4-diamine; 6-(2-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(4-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-[3,5-bis(trifluoromethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 6-(isoquinolin-4-yl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 4-N-methyl-6-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2H-1,3-benzodioxol-5-yl)-4-N-methylpyrimidine-2,4-diamine; 3-[2-amino-6-(methylamino)pyrimidin-4-yl]benzonitrile; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}acetamide; 4-N-methyl-6-[4-(morpholine-4-sulfonyl)phenyl]pyrimidine-2,4-diamine; 6-(4-methanesulfonylphenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-[3-(morpholine-4-carbonyl)phenyl]pyrimidine-2,4-diamine; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]-N-(furan-2-ylmethyl)benzamide; N-{4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}methanesulfonamide; N-{4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}acetamide; 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]-N\u2032-hydroxy-benzamidine; 6-(6-methoxypyridin-3-yl)-4-N-methylpyrimidine-2,4-diamine; 6-(2-fluoro-4-phenylphenyl)-4-N-methylpyrimidine-2,4-diamine; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]benzonitrile; 6-(4-chlorophenyl)-4-N-(prop-2-en-1-yl)pyrimidine-2,4-diamine; 6-(4-methoxyphenyl)-4-N-(prop-2-en-1-yl)pyrimidine-2,4-diamine; 6-(4-chlorophenyl)-4-N-cyclopentylpyrimidine-2,4-diamine; 4-N-cyclopentyl-6-(4-methoxyphenyl)pyrimidine-2,4-diamine; 4-N-cyclopentyl-6-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 6-(4-chlorophenyl)-4-N-cyclobutylpyrimidine-2,4-diamine; 4-N-cyclobutyl-6-(4-methoxyphenyl)pyrimidine-2,4-diamine; 4-N-cyclobutyl-6-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-pentylpyrimidine-2,4-diamine; 4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 4-N-tert-butyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 4-N-cyclobutyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 4-N-cyclopentyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-ethylpyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-(oxolan-3-yl)pyrimidine-2,4-diamine; 6-(3,4-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(4-tert-butylphenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-(4-methylphenyl)pyrimidine-2,4-diamine; 6-(2,4-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-(2,4,5-trifluorophenyl)pyrimidine-2,4-diamine; 6-(4-fluoro-2-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(5-chloro-2-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,4-difluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(5-fluoro-2-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2-chlorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-N4-[2-(3-methylsulfonylanilino)ethyl]pyrimidine-2,4-diamine; 6-(4-methoxy-3-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(3-chloro-4-fluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-[4-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine; 6-(3-fluoro-4-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(3,4-difluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-[4-(propan-2-yloxy)phenyl]pyrimidine-2,4-diamine; 6-[2-fluoro-3-(trifluoromethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(3-chloro-2-fluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(4-chloro-3-fluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-[2-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 4-N-methyl-6-(1-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine; 6-[2-chloro-3-(trifluoromethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 6-(2-chloro-3-fluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,3-difluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(7-chloro-2H-1,3-benzodioxol-5-yl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,3-dichloro-4-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,3-dichloro-5-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenol; {3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}methanol; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]benzoic acid; methyl 4-[2-amino-6-(methylamino)pyrimidin-4-yl]benzoate; 6-[3-chloro-4-(morpholine-4-carbonyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]-2,3-dichlorophenol; methyl (2E)-3-{4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}prop-2-enoate; methyl (2E)-3-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}prop-2-enoate; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]benzaldehyde 1-(4-(2-amino-6-(methylamino)pyrimidin-4-yl)phenyl)ethanone; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]-N-methylbenzamide; 6-(4-ethenylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(piperidin-1-yl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(morpholin-4-yl)ethyl]pyrimidine-2,4-diamine; 4-N-cyclopropyl-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 3-[2-amino-6-(methylamino)pyrimidin-4-yl]-N-(4-methylphenyl)benzamide; 6-(1H-indol-3-yl)-4-N-methylpyrimidine-2,4-diamine; 6-phenyl-4-N-(2-phenylethyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(2-phenylethyl)pyrimidine-2,4-diamine; 6-(3-chlorophenyl)-4-N-(2,2-difluoroethyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methoxypyridin-4-yl)-4-N-methylpyrimidine-2,4-diamine; 6-(3,5-difluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(4-methoxyphenyl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(2-methoxyphenyl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(4-methylphenyl)ethyl]pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(pyridin-2-yl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(2-phenylpropyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(3-phenylpropyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(2-phenoxyethyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(phenylamino)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(1H-indol-3-yl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-pentylpyrimidine-2,4-diamine; 1-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)imidazolidin-2-one; 1-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]-2,6-dimethylphenol; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]-2-methoxyphenol; 4-[2-amino-6-(methylamino)pyrimidin-4-yl]-2-fluorophenol; 5-[2-amino-6-(methylamino)pyrimidin-4-yl]pyridin-2-ol; {4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}methanol; 4-N-methyl-6-(2-methylphenyl)pyrimidine-2,4-diamine; 6-[1-(4-chlorobenzenesulfonyl)-1H-indol-3-yl]-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-(4-methyl-1H-indazol-5-yl)pyrimidine-2,4-diamine; 4-N-methyl-6-(6-methyl-1H-indazol-5-yl)pyrimidine-2,4-diamine; 4-N-methyl-6-(3-methylphenyl)pyrimidine-2,4-diamine; 6-(1H-indol-5-yl)-4-N-methylpyrimidine-2,4-diamine; 6-(3-chloropyridin-4-yl)-4-N-methylpyrimidine-2,4-diamine; {5-[2-amino-6-(methylamino)pyrimidin-4-yl]pyridin-2-yl}methanol; 4-N-cyclobutyl-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-cyclobutyl-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 4-N-cyclopentyl-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-cyclopentyl-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 4-N-methyl-6-{1-[4-(trifluoromethyl)benzenesulfonyl]-1H-indol-3-yl}pyrimidine-2,4-diamine; 4-N-cyclohexyl-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-cyclohexyl-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-ethylpyrimidine-2,4-diamine; 4-N-ethyl-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 4-N-tert-butyl-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-tert-butyl-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(propan-2-yl)pyrimidine-2,4-diamine; 6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]-4-N-(propan-2-yl)pyrimidine-2,4-diamine; 4-N-(cyclopropylmethyl)-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-(cyclopropylmethyl)-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 4-N-[(1R)-1-cyclopropylethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-[(1R)-1-cyclopropylethyl]-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 4-N-[(1S)-1-cyclopropylethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-[(1S)-1-cyclopropylethyl]-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 6-(1-benzofuran-3-yl)-4-N-methylpyrimidine-2,4-diamine; 6-(2-chloro-5-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(1-benzothiophen-3-yl)-4-N-methylpyrimidine-2,4-diamine; 2-{4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}propan-2-ol; 6-(1H-indol-4-yl)-4-N-methylpyrimidine-2,4-diamine; 4-N-cyclohexyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-(propan-2-yl)pyrimidine-2,4-diamine; 4-N-(cyclopropylmethyl)-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 4-N-[(1S)-1-cyclopropylethyl]-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 4-N-[(1R)-1-cyclopropylethyl]-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-(2,2-dimethylpropyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(2,2-dimethylpropyl)pyrimidine-2,4-diamine; 4-N-(2,2-dimethylpropyl)-6-[1-(4-methylbenzenesulfonyl)-1H-indol-3-yl]pyrimidine-2,4-diamine; 6-(5-bromo-2-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,5-dimethylphenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-[2-(trifluoromethyl)pyridin-3-yl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(3-methylsulfonylanilino)ethyl]pyrimidine-2,4-diamine; 6-[4-(benzyloxy)-2-methylphenyl]-4-N-methylpyrimidine-2,4-diamine; 6-(4-methoxy-2,5-dimethylphenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-(2,4,5-trimethylphenyl)pyrimidine-2,4-diamine; 2-[2-amino-6-(methylamino)pyrimidin-4-yl]-4-chlorobenzonitrile; 6-(4,5-dichloro-2-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,5-dichloro-4-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(4-fluoro-2,5-dimethylphenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-[2-methyl-5-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 6-[5-chloro-2-methyl-4-(trifluoromethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 6-[2,5-bis(trifluoromethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 6-(5-tert-butyl-2-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-[2-methoxy-5-(propan-2-yl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 6-[2-chloro-5-(trifluoromethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 6-(2-fluoro-5-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(5-chloro-2-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(5-fluoro-2-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,5-dimethoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2-methoxy-5-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2-chloro-5-fluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 3-[2-amino-6-(methylamino)pyrimidin-4-yl]-4-fluorobenzonitrile; 6-(2-chloro-5-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-[5-fluoro-2-(trifluoromethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 6-(2,5-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(5-chloro-2-fluorophenyl)-4-N-methylpyrimidine-2,4-diamine; 3-[2-amino-6-(methylamino)pyrimidin-4-yl]-4-methylbenzonitrile; 3-[2-amino-6-(methylamino)pyrimidin-4-yl]-4-methoxybenzonitrile; 6-(2-chloro-5-fluoro-4-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(5-chloro-2-fluoro-4-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2-chloro-4-fluoro-5-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 4-N-cyclopropyl-6-(4-fluoro-2,5-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-cyclopropyl-6-(4-methoxy-2,5-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-cyclopropyl-6-(2,5-dimethylphenyl)pyrimidine-2,4-diamine; 6-(5-chloro-2-methylphenyl)-4-N-cyclopropylpyrimidine-2,4-diamine; 6-(5-chloro-2-methylphenyl)-4-N-cyclobutylpyrimidine-2,4-diamine; 6-(5-chloro-2-methylphenyl)-4-N-ethylpyrimidine-2,4-diamine; 6-(5-chloro-2-methylphenyl)-4-N-[2-(4-chlorophenyl)ethyl]pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-(4-fluoro-2,5-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-(2,5-dimethylphenyl)pyrimidine-2,4-diamine; 1-(3-{[2-amino-6-(quinolin-5-yl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 6-(2-chloro-3-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2-chloro-3-methylphenyl)-4-N-cyclopropylpyrimidine-2,4-diamine; 6-(2-chloro-3-methylphenyl)-4-N-[2-(4-chlorophenyl)ethyl]pyrimidine-2,4-diamine; 1-(3-{[2-amino-6-(2-chloro-3-methylphenyl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 4-N-cyclopropyl-6-(1H-indol-4-yl)pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-(1H-indol-4-yl)pyrimidine-2,4-diamine; 4-N-cyclopropyl-6-(quinolin-5-yl)pyrimidine-2,4-diamine; (2E)-3-{4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}prop-2-enoic acid; tert-butyl 3-({[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}methyl)-azetidine-1-carboxylate; 4-N-cyclopropyl-6-(1H-indol-5-yl)pyrimidine-2,4-diamine; 1-(3-{[2-amino-6-(1H-indol-5-yl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; tert-butyl 4-((2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl)amino)piperidine-1-carboxylate; ethyl 4-((2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl)amino)piperidine-1-carboxylate; tert-butyl (3-((2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl)amino)-2,2-dimethyl-propyl)carbamate; 6-(5-chloro-4-methoxy-2-methylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-[(1R)-1-phenylethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-(2-phenylpropan-2-yl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-[1-(1H-indol-3-yl)propan-2-yl]pyrimidine-2,4-diamine; 4-N-{bicyclo[221]heptan-2-yl}-6-(3-chloro-2-methylphenyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-ethylpyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-(propan-2-yl)pyrimidine-2,4-diamine; 4-N-[2-(2-chlorophenoxy)ethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-[2-(5-chloro-1H-1,3-benzodiazol-2-yl)ethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-[2-(2,5-dimethyl-1H-indol-3-yl)ethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(pyridin-3-yloxy)propyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(1H-indazol-5-ylmethyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(1H-indazol-6-ylmethyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[(2-methoxypyridin-4-yl)methyl]pyrimidine-2,4-diamine; 4-N-[(5-chloropyrazin-2-yl)methyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{imidazo[1,2-a]pyridin-2-ylmethyl}pyrimidine-2,4-diamine; tert-butyl 4-{4-[2-amino-6-(methylamino)pyrimidin-4-yl]-2-(methoxymethyl)phenoxymethyl}piperidine-1-carboxylate; 6-[3-(methoxymethyl)-4-(piperidin-4-ylmethoxy)phenyl]-4-N-methylpyrimidine-2,4-diamine; 3-[2-amino-6-(methylamino)pyrimidin-4-yl]-2-methylbenzonitrile; 6-(4-methoxy-2,3-dimethylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(4-fluoro-2,3-dimethylphenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,3-dihydro-1-benzofuran-7-yl)-4-N-methylpyrimidine-2,4-diamine; 4-N-methyl-6-[2-methyl-5-(morpholine-4-sulfonyl)phenyl]pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-(2-methylphenyl)pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-(quinolin-5-yl)pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)cyclopropyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(pyridin-3-yl)ethyl]pyrimidine-2,4-diamine; 3-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)phenol; 6-(2,3-dimethylphenyl)-4-N-[3-(morpholin-4-yl)propyl]pyrimidine-2,4-diamine; tert-butyl N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-carbamate; N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)acetamide; benzyl N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-carbamate; tert-butyl N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-N-methylcarbamate; tert-butyl N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-carbamate; 6-(2,3-dimethylphenyl)-4-N-[3-(5-methyl-1H-pyrazol-3-yl)propyl]pyrimidine-2,4-diamine; 3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}-1-(morpholin-4-yl)propan-1-one; 4-N-[(4-benzylmorpholin-2-yl)methyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[(4-methanesulfonylphenyl)methyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{[4-(4-methylpiperazin-1-yl)phenyl]methyl}pyrimidine-2,4-diamine; 4-N-[(3S)-1-azabicyclo[222]octan-3-yl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; tert-butyl 2-({[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}methyl)-pyrrolidine-1-carboxylate; tert-butyl 4-({[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}methyl)-piperidine-1-carboxylate; 1-(3-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 1-(3-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 1-(3-{[2-amino-6-(4-fluoro-2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 1-(3-{[2-amino-6-(4-methoxy-2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 1-(3-{[2-amino-6-(4-methyl-1H-indazol-5-yl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 1-[3-({2-amino-6-[2-methyl-5-(morpholine-4-sulfonyl)phenyl]pyrimidin-4-yl}amino)propyl]pyrrolidin-2-one; 1-(3-{[2-amino-6-(2,3-dihydro-1-benzofuran-7-yl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 1-(3-{[2-amino-6-(2,5-dimethylphenyl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 1-(3-{[2-amino-6-(5-chloro-2-methylphenyl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 1-[3-({2-amino-6-[2-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)propyl]pyrrolidin-2-one; 1-(3-{[2-amino-6-(1H-indol-4-yl)pyrimidin-4-yl]amino}propyl)pyrrolidin-2-one; 4-N-{[1-(4-chlorophenyl)cyclopropyl]methyl}-dimethylphenyl)pyrimidine-2,4-diamine; 4-(2-[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]aminoethyl)benzene-1-sulfonamide; 4-{2-[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-N-(adamantan-1-yl)-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[311]heptan-3-yl]pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-({3-[(4-methylpiperidin-1-yl)methyl]phenyl}methyl)-pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}ethyl)phenol; ethyl 4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}piperidine-1-carboxylate; N-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)acetamide; 6-(2,3-dichlorophenyl)-4-N-{tricyclo[3310 3 ,7]nonan-3-yl}pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-{[4-(1,2,3-thiadiazol-4-yl)phenyl]methyl}pyrimidine-2,4-diamine; 4-N-[2-(1-benzylpiperidin-4-yl)ethyl]-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 6-[2-[[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino]ethylamino]-2,2-dimethyl-4H-1,4-benzoxazin-3-one; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-3-hydroxypyridine-2-carboxamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}prop-2-enamide; (2E)-N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-3-phenylprop-2-enamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]-2-methylphenyl}prop-2-enamide; (2E)-N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-4-(dimethylamino)but-2-enamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}ethene-1-sulfonamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}prop-2-ynamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-2-oxopropanamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-2-oxo-2-phenylacetamide; N-{4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}prop-2-enamide; N-({4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}methyl)prop-2-enamide; N-({3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}methyl)prop-2-enamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]-4-methylphenyl}prop-2-enamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-5-chloro-2-hydroxybenzamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-2-hydroxyacetamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-2-(4-chlorophenyl)-2-hydroxyacetamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-2-hydroxy-2-phenylacetamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-4-oxo-4-(pyrrolidin-1-yl)butanamide; N-{3-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-2-hydroxybenzamide; 1-{4-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}-2,2,2-trifluoroethan-1-one; 6-[3-(aminomethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 6-[4-(aminomethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 6-(2,3-dimethylphenyl)-4-N-[2-(4-methanesulfonylphenyl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(5-methyl-1H-1,2,4-triazol-3-yl)ethyl]pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzonitrile; 6-(2,3-dimethylphenyl)-4-N-[2-(pyridin-4-yl)ethyl]pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethoxy)benzonitrile; 4-({[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}methyl)benzene-1-sulfonamide; 1-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-1,2-dihydropyridin-2-one; 3-({[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}methyl)-1,2-dihydropyridin-2-one; 6-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-5H,6H,7H-pyrrolo[3,4-b]pyridin-5-one; 6-({[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}methyl)pyridin-3-ol; 4-N-[2-(3-chlorophenyl)ethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[3-(1H-imidazol-1-yl)propyl]pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)propyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(4-fluorophenyl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(4-methoxyphenyl)-2-(pyrrolidin-1-yl)ethyl]pyrimidine-2,4-diamine; 4-N-{[4-(dimethylamino)phenyl]methyl}-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-[2-(benzenesulfonyl)ethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{[1-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{2-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]ethyl}pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{[1-(pyrimidin-2-yl)piperidin-3-yl]methyl}pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(6-methoxy-1H-1,3-benzodiazol-2-yl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(4-methyl-1,3-thiazol-5-yl)ethyl]pyrimidine-2,4-diamine; 4-N-[(3-cyclopropyl-1H-pyrazol-5-yl)methyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-[3-(3,5-dimethyl-1H-pyrazol-1-yl)propyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{[1-(pyridin-2-yl)piperidin-3-yl]methyl}pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[(2-phenyl-2H-1,2,3-triazol-4-yl)methyl]pyrimidine-2,4-diamine; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-4-chlorobenzene-1-sulfonamide; 3-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-1-(4-chlorophenyl)urea; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-3,5-dimethyl-1,2-oxazole-4-sulfonamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-2-(dimethylamino)acetamide; 3-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-1-(2,6-dichloropyridin-4-yl)urea; 3-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-1-(3,4-difluorophenyl)urea; N-[3-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propoxy)phenyl]acetamide; 6-(2,3-dimethylphenyl)-4-N-[(2-methyl-1H-indol-5-yl)methyl]pyrimidine-2,4-diamine; 4-N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[4-(pyrrolidin-1-yl)butyl]pyrimidine-2,4-diamine; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-3-bromobenzamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)benzamide; 1-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-3-(propan-2-yl)urea; tert-butyl N-(4-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}butyl)-carbamate; tert-butyl N-(5-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}pentyl)-carbamate; tert-butyl N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}cyclohexyl)-carbamate; tert-butyl N-(1-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}-2-methylpropan-2-yl)carbamate; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-3-cyanobenzene-1-sulfonamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-4-methanesulfonylbenzene-1-sulfonamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)benzene-sulfonamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}-2,2-dimethylpropyl)-3-fluorobenzene-1-sulfonamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}-2,2-dimethylpropyl)-4-(morpholine-4-sulfonyl)benzene-1-sulfonamide; 6-(2,3-dimethylphenyl)-4-N-(prop-2-en-1-yl)pyrimidine-2,4-diamine; 1-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)imidazolidin-2-one; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-3-fluorobenzene-1-sulfonamide; N-{4-[(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)sulfamoyl]-phenyl}acetamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)methanesulfonamide; N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-3-fluorobenzene-1-sulfonamide; N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-4-methoxybenzene-1-sulfonamide; 6-(2,3-dimethylphenyl)-4-N-(prop-2-yn-1-yl)pyrimidine-2,4-diamine; 2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}acetamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-4,5-dichlorothiophene-2-sulfonamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonamide; 2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}acetonitrile; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-1,2-dimethyl-1H-imidazole-4-sulfonamide; N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonamide; 4-N-{2-[(1,3-benzoxazol-2-yl)amino]ethyl}-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(4-phenylbutan-2-yl)pyrimidine-2,4-diamine; 4-N-(2,2-dimethyloxan-4-yl)-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; ethyl 2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}acetate; 6-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyridine-3-carbonitrile; 4-N-{2-[(3-bromo-1,2,4-thiadiazol-5-yl)amino]ethyl}-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[(5-methyl-4H-1,2,4-triazol-3-yl)methyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{2-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl}pyrimidine-2,4-diamine; N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-4-methanesulfonylbenzene-1-sulfonamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-3-methanesulfonylbenzene-1-sulfonamide; N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)-2-methanesulfonylbenzene-1-sulfonamide; 6-(2,3-dimethylphenyl)-4-N-[2-(4-methanesulfonylphenyl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-[2-(4-methyl-1,3-thiazol-5-yl)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-[2-(4-methyl-1,3-thiazol-5-yl)ethyl]pyrimidine-2,4-diamine; 4-N-{[2-(difluoromethyl)pyridin-4-yl]methyl}-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(1H-imidazol-4-yl)ethyl]pyrimidine-2,4-diamine; 4-N-[3-(1H-1,3-benzodiazol-2-yl)propyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[(1-methyl-1H-1,3-benzodiazol-2-yl)methyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[(2-phenyl-1,3-thiazol-5-yl)methyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-[2-(5-methyl-1H-1,2,4-triazol-3-yl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-[2-(5-methyl-1H-1,2,4-triazol-3-yl)ethyl]pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)-N,N-dimethylbenzene-1-sulfonamide; 4-(2-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}ethyl)-N,N-dimethylbenzene-1-sulfonamide; 4-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-N,N-dimethylbenzene-1-sulfonamide; 4-N-{1-[(4-chlorophenyl)methyl]cyclopropyl}-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-cyclopropyl-6-(2,3,4-trichlorophenyl)pyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-(2,3,4-trichlorophenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-( 2 H 3 )methylpyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-( 2 H 3 )methylpyrimidine-2,4-diamine; 6-(2-chloro-3-methylphenyl)-4-N-( 2 H 3 )methylpyrimidine-2,4-diamine; 4-N-[2-(4-chlorophenyl)ethyl]-6-(1H-pyrrol-2-yl)pyrimidine-2,4-diamine; N-(4-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}butyl)-4-methanesulfonylbenzene-1-sulfonamide; 4-(2-{[2-amino-6-(4-fluoro-2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(3-cyano-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(5-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(3,4-dichloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 6-(3-chloro-2-methylphenyl)-4-N-(prop-2-yn-1-yl)pyrimidine-2,4-diamine; 6-(4-fluoro-2,3-dimethylphenyl)-4-N-[2-(4-methanesulfonylphenyl)ethyl]pyrimidine-2,4-diamine; 6-(3,4-dichloro-2-methylphenyl)-4-N-[2-(4-methanesulfonylphenyl)ethyl]pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(4-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(2-chloro-4-fluorophenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(2,3,4-trifluorophenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(4-fluoro-3-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-N-cyclopropyl-6-(4-fluoro-2,3-dimethylphenyl)pyrimidine-2,4-diamine; 3-[2-amino-6-(cyclopropylamino)pyrimidin-4-yl]-2-methylbenzonitrile; 6-(2,3-dichlorophenyl)-4-N-(prop-2-yn-1-yl)pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(4-fluoro-2,5-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-N-[2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-{2-[(6-chloropyridazin-3-yl)amino]ethyl}-dimethylphenyl)pyrimidine-2,4-diamine; 2-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyridine-4-carbonitrile; 6-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyridine-3-sulfonamide; 1-N-(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)benzene-1,4-disulfonamide; 6-(2,3-dichlorophenyl)-4-N-[2-(4-methanesulfonylphenyl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[1-(1H-pyrazol-1-yl)propan-2-yl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{2-[(3-methoxyphenyl)amino]ethyl}pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{2-[(3-fluoro-4-methylphenyl)amino]ethyl}pyrimidine-2,4-diamine; 4-N-{2-[(3,4-dichlorophenyl)amino]ethyl}-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-{2-[(5-chloropyridin-2-yl)amino]ethyl}-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-{2-[(5-bromopyridin-2-yl)amino]ethyl}-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]benzene-1-sulfonamide; 4-N-[2-(4-chlorophenyl)ethyl]-6-(dimethyl-1,2-oxazol-4-yl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{2-[(pyridin-3-yl)amino]ethyl}pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-[2-(4-methanesulfonylphenyl)ethyl]pyrimidine-2,4-diamine; [4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-morpholino-methanone; 6-[(3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}propyl)amino]pyridine-3-sulfonamide; 6-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-N-methylpyridine-3-sulfonamide; 6-(2,3-dichlorophenyl)-4-N-{2-[(pyridin-4-yl)amino]ethyl}pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(5-methylfuran-2-yl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 6-(3-chloro-2-methylphenyl)-4-N-[2-(4-chlorophenyl)ethyl]pyrimidine-2,4-diamine; 6-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyridine-3-carboxamide; 4-N-methyl-6-(thiophen-3-yl)pyrimidine-2,4-diamine; 4-N-methyl-6-(4-methylthiophen-2-yl)pyrimidine-2,4-diamine; 4-N-methyl-6-(1-methyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine; 4-N-{2-[(5-bromopyridin-2-yl)amino]ethyl}-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine; 4-N-methyl-6-(3-methyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine; 4-N-methyl-6-(1H-pyrrol-3-yl)pyrimidine-2,4-diamine; N-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)-2-methoxyacetamide; N-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)-2,2,2-trifluoroacetamide; N-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)-4-methanesulfonylbenzamide; N-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)-1,2-oxazole-5-carboxamide; N-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)-3,4-dichlorobenzamide; N-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)-2,2-dimethylpropanamide; N-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)-4-methanesulfonylbenzene-1-sulfonamide; 3-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)-1-[4-(methyl sulfanyl)phenyl]urea; 3-(4-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)-1-(4-methanesulfinylphenyl)urea; 4-N-methyl-6-(2-methylfuran-3-yl)pyrimidine-2,4-diamine; 4-N-methyl-6-[5-(pyrrolidin-1-ylmethyl)thiophen-2-yl]pyrimidine-2,4-diamine; 6-(4-fluoro-2,5-dimethylphenyl)-4-N-{2-[(5-nitropyridin-2-yl)amino]ethyl}pyrimidine-2,4-diamine; [2-(2-amino-6-{[2-(4-chlorophenyl)ethyl]amino}pyrimidin-4-yl)phenyl]methanol; 6-(3-chloro-2-methylphenyl)-4-N-cyclopropylpyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-(2-fluoroethyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(2-fluoroethyl)pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzoic acid; 4-(2-{[6-(2-acetylthiophen-3-yl)-2-aminopyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 3-{4-[2-amino-6-(methylamino)pyrimidin-4-yl]-1H-pyrazol-1-yl}propanamide; N-{6-[(2-{[2-amino-6-(4-fluoro-2,5-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyridin-3-yl}acetamide; N-{6-[(2-{[2-amino-6-(4-fluoro-2,5-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyridin-3-yl}methanesulfonamide; 6-(2,3-dimethylphenyl)-4-N-{2-[(6-methoxy-4-methylpyridin-3-yl)amino]ethyl}pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{2-[(6-methanesulfonylpyridin-3-yl)amino]ethyl}pyrimidine-2,4-diamine; 5-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyridine-3-sulfonamide; [4-[2-[[2-amino-6-(3,5-dichloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-morpholino-methanone; 4-[(1R,2S)-2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}cyclopropyl]benzene-1-sulfonamide; 2-[3-(2-amino-6-{[2-(4-chlorophenyl)ethyl]amino}pyrimidin-4-yl)phenoxy]acetamide; 2-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyrimidine-4-carboxamide; 6-(2,3-dimethylphenyl)-4-N-{2-[(pyrazin-2-yl)amino]ethyl}pyrimidine-2,4-diamine; 4-N-{2-[(6-chloropyrimidin-4-yl)amino]ethyl}-dimethylphenyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[3-(3-methylsulfonylanilino)propyl]pyrimidine-2,4-diamine; 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzenecarbothioamide; 4-(2-amino-6-{[2-(4-methanesulfonylphenyl)ethyl]amino}pyrimidin-4-yl)-N-tert-butylthiophene-2-sulfonamide; tert-butyl N-{[5-(2-amino-6-{[2-(4-methanesulfonylphenyl)ethyl]amino}pyrimidin-4-yl)thiophen-2-yl]methyl}carbamate; N-[4-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]acetamide; N-[4-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]methanesulfonamide; {2-[2-amino-6-(methylamino)pyrimidin-4-yl]phenyl}methanol; 4-[2-({2-amino-6-[2-(hydroxymethyl)phenyl]pyrimidin-4-yl}amino)ethyl]benzene-1-sulfonamide; 4-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-N-methylbenzene-1-sulfonamide; N-{4-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-2-methylphenyl}acetamide; 6-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-3,4-dihydro-2H-1,4-benzoxazin-3-one; 2-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]benzamide; 2-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyridine-4-carboxamide; 6-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethoxy)pyridine-3-carboxamide; N-[3-(2-amino-6-{[2-(4-methanesulfonylphenyl)ethyl]amino}pyrimidin-4-yl)-2-methylphenyl]-4-chloro-2-hydroxybenzamide; 3-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-1H-indol-5-ol; 4-N-{2-[5-(benzyloxy)-1H-indol-3-yl]ethyl}-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 4-N-[2-(5-bromo-1H-indol-3-yl)ethyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(7-methyl-1H-indol-3-yl)ethyl]pyrimidine-2,4-diamine; 4-N-{2-[7-(benzyloxy)-1H-indol-3-yl]ethyl}-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-[2-(6-methoxy-1H-indol-3-yl)ethyl]pyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-(2-methylcyclopropyl)pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(3-hydroxyphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; ethyl 6-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyridine-3-carboxylate; 4-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-2-(trifluoromethyl)benzene-1-sulfonamide; 4-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]benzamide; ethyl N-[4-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]carbamate; 5-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-2-methoxybenzene-1-sulfonamide; 3-(2-amino-6-{[2-(4-sulfamoylphenyl)ethyl]amino}pyrimidin-4-yl)phenyl methanesulfonate; 3-(2-amino-6-{[2-(4-sulfamoylphenyl)ethyl]amino}pyrimidin-4-yl)phenyl trifluoromethanesulfonate; 4-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzoic acid; 6-[(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-3,4-dihydro-2H-1,4-benzoxazin-3-one; 6-(2,3-dimethylphenyl)-4-N-{2-[(2-methyl-1,3-benzothiazol-6-yl)amino]ethyl}pyrimidine-2,4-diamine; 6-[(2-{[2-amino-6-(3-chlorophenyl)pyrimidin-4-yl]amino}ethyl)amino]-3,4-dihydro-2H-1,4-benzoxazin-3-one; 6-[(2-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}ethyl)amino]-3,4-dihydro-2H-1,4-benzoxazin-3-one; 6-(2,3-dichlorophenyl)-4-N-{2-[(2-methyl-1,3-benzothiazol-6-yl)amino]ethyl}pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-(2-{[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl]amino}ethyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{2-[(3-methanesulfonylphenyl)amino]ethyl}pyrimidine-2,4-diamine; 5-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-2-methoxybenzene-1-sulfonic acid; 4-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-3-fluorobenzene-1-sulfonamide; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzamide; 4-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzamide; 4-N-{2-[(2-amino-9H-purin-6-yl)amino]ethyl}-dimethylphenyl)pyrimidine-2,4-diamine; N-[3-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]acetamide; ethyl N-[3-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]carbamate; 6-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one; 4-N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; methyl 5-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]pyrazine-2-carboxylate; methyl 2-[(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-6-methylpyrimidine-4-carboxylate; 4-N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)pyrimidine-2,4-diamine; 6-(2,3-dimethylphenyl)-4-N-{2-[(9H-purin-6-yl)amino]ethyl}pyrimidine-2,4-diamine; 1-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-3-ethyl-urea; 6-(3-chloro-2-methylphenyl)-4-N-[2-(3-methanesulfonylphenyl)ethyl]pyrimidine-2,4-diamine; 5-N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)pyridine-2,5-diamine; 1-N-(2-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)-2-fluorobenzene-1,4-diamine; 1-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-3-tert-butyl-urea; 1-allyl-3-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]urea; ethyl N-[[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]carbamoyl]carbamate; 1-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-3-sec-butyl-urea; 1-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-3-ethyl-thiourea; N-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]morpholine-4-carboxamide; isopropyl N-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]carbamate; isobutyl N-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]carbamate; 2,2-dimethylpropyl N-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]carbamate; 2-methoxyethyl N-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]carbamate; 6-[2-[[2-amino-6-(3-chlorophenyl)pyrimidin-4-yl]amino]ethylamino]-2,2-dimethyl-4H-1,4-benzoxazin-3-one; 6-(3-chloro-2-methylphenyl)-4-N-(2-methylcyclopropyl)pyrimidine-2,4-diamine; 3-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 3-(2-{[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; but-2-ynyl N-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]carbamate; [4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]cyanamide; 6-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethoxy)pyridine-3-carboxamide; 6-[(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)amino]-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one; 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzamidine; 4-N-(azetidin-3-yl)-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine; tert-butyl 3-{[2-amino-6-(2,3-dimethylphenyl)pyrimidin-4-yl]amino}azetidine-1-carboxylate; 2-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethoxy)pyrimidine-4-carboxamide; 2-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethoxy)pyrimidine-4-carboxylic acid; N-[4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]-2,2-dimethylpropanamide; N-[4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]-2,2,2-trifluoroethane-1-sulfonamide; 1-[4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]-3-(propan-2-yl)urea; tert-butyl N-[4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]carbamate; N-[4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]cyclopropanecarboxamide; 6-(2,3-dimethylphenyl)-4-N-[2-(thiophen-2-yl)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-[2-(3,4-dichlorophenyl)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-4-N-[2-(2,4-dichlorophenyl)ethyl]pyrimidine-2,4-diamine; N-[4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]ethane-1-sulfonamide; 4-(2-{[2-amino-6-(2,4,5-trimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(4-methoxy-2,5-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(4,5-dichloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(5-chloro-4-methoxy-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(1H-indol-4-yl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(2,5-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(5-fluoro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(3,4,5-trichloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(5-chloro-2-fluoro-3-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(3,5-dichloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(3,4,5-trichloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzamide; 4-(2-{[2-amino-6-(3,5-dichloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzamide; 4-(2-{[2-amino-6-(4-fluoro-2,3-dimethylphenyl)pyrimidin-4-yl]amino}ethyl)benzamide; 4-(2-{[2-amino-6-(3,4-dichloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzamide; 4-(2-{[2-amino-6-(5-chloro-2-fluoro-3-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzamide; 4-(2-{[2-amino-6-(3-chloro-2-fluorophenyl)pyrimidin-4-yl]amino}ethyl)benzamide; N-[3-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]-2,2-dimethylpropanamide; 1-[3-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]-3-(propan-2-yl)urea; tert-butyl N-[3-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]carbamate; N-[3-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]cyclopropanecarboxamide; N-[3-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]-2-methylpropane-1-sulfonamide; N-[4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]propane-2-sulfonamide; N-[4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)phenyl]-2-methylpropane-1-sulfonamide; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)benzonitrile 3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzamide; 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]-N-methyl-benzamide; [4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-pyrrolidin-1-yl-methanone; 7-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]-4H-1,4-benzoxazin-3-one; 6-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]-4-methyl-1,4-benzoxazin-3-one; 7-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]-3H-quinazolin-4-one; 6-[2-[[2-amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino]ethylamino]-4-methyl-1,4-benzoxazin-3-one; 6-(3-chloro-2-methylphenyl)-4-N-[2-(3-nitrophenyl)ethyl]pyrimidine-2,4-diamine; 4-[2-[[2-amino-6-(2-chloro-3-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzenesulfonamide; 4-[2-[[2-amino-6-(2,3,5-trichlorophenyl)pyrimidin-4-yl]amino]ethyl]benzenesulfonamide; 4-[2-[[2-amino-6-(2,3,4-trichlorophenyl)pyrimidin-4-yl]amino]ethyl]benzenesulfonamide; 4-[2-[[2-amino-6-(2,4-dichloro-3-methoxy-phenyl)pyrimidin-4-yl]amino]ethyl]benzenesulfonamide; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-[(2-methyl-1,3-benzothiazol-6-yl)amino]ethyl]pyrimidine-2,4-diamine; 4-[2-[[2-amino-6-(benzothiophen-3-yl)pyrimidin-4-yl]amino]ethyl]benzenesulfonamide; N4-[2-(4-aminophenyl)ethyl]-6-(3-chloro-2-methyl-phenyl)pyrimidine-2,4-diamine; 4-[3-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]propylamino]benzamide; 4-[3-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]propylamino]-N-methyl-benzenesulfonamide; 6-(3-chloro-2-methyl-phenyl)-N4-[3-[(2-methyl-1,3-benzothiazol-6-yl)amino]propyl]pyrimidine-2,4-diamine; 2-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]pyrimidine-4-carboxamide; 6-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]pyridine-3-carboxamide; 1-[3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-3-ethyl-urea; 1-[3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-3-tert-butyl-urea; N-[3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]morpholine-4-carboxamide; 3-[3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]-1,1-dimethyl-urea; N-[3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]pyrrolidine-1-carboxamide; isopropyl N-[3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]carbamate; isobutyl N-[3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]carbamate; 2,2-dimethylpropyl N-[3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]carbamate; 1-[6-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]-3-pyridyl]-3-tert-butyl-urea; tert-butyl N-[6-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]-3-pyridyl]carbamate; N2-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]-1,3,5-triazine-2,4,6-triamine; 2-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]-4-(trifluoromethyl)pyrimidine-5-carboxamide; N-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]-3-fluoro-benzenesulfonamide; 2-(2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-ylamino)-1-(4-(methylsulfonyl)phenyl)ethanol; N-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]morpholine-4-carboxamide; 1-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]-3-(3-fluorophenyl)urea; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(4-isopropylsulfonylanilino)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(4-methylsulfinylanilino)ethyl]pyrimidine-2,4-diamine; 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]-3-fluoro-benzamide; 6-[3-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]azetidin-1-yl]phenyl-3-sulfonamide; tert-butyl N-[3-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]propyl]carbamate; 4-[3-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]propylamino]benzenesulfonamide; 4-[[3-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]-2,2-dimethyl-propyl]amino]benzenesulfonamide; 6-(3-chloro-2-methyl-phenyl)-N4-[2,2-dimethyl-3-[(2-methyl-1,3-benzothiazol-6-yl)amino]propyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(3-isopropylsulfonylanilino)ethyl]pyrimidine-2,4-diamine; 6-[3-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]propylamino]pyridine-3-carboxamide; 2-[3-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]propylamino]pyrimidine-4-carboxamide; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(4-isopropylsulfonylphenyl)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(3-isopropylsulfonylphenyl)ethyl]pyrimidine-2,4-diamine; 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]-2-fluoro-benzamide; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(3-fluoro-4-methylsulfonyl-phenyl)ethyl]pyrimidine-2,4-diamine; 5-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]-2-hydroxy-benzamide; 6-(3-chloro-2-methyl-phenyl)-N4-(4-phenylbutyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(cyclohexen-1-yl)ethyl]pyrimidine-2,4-diamine; N4-but-3-enyl-6-(3-chloro-2-methyl-phenyl)pyrimidine-2,4-diamine; 5-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]naphthalene-1-sulfonic acid; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(cyclopropylmethoxy)ethyl]pyrimidine-2,4-diamine; 2-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylsulfanyl]pyrimidine-4-carboxamide; 6-(3-chloro-2-methyl-phenyl)-N4-(3,3-difluoroallyl)pyrimidine-2,4-diamine; N4-(3-bromo-3,3-difluoro-propyl)-6-(3-chloro-2-methyl-phenyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-[[5-[(dimethylamino)methyl]-2-furyl]methylsulfanyflethyl]ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-[(4-methylsulfonylphenyl)methylsulfanyl]ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-N4-{2-[(2-phenylethyl)sulfanyl]ethyl}pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-[(4-methylsulfonylphenyl)methylsulfinyl]ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(2-phenylethylsulfinyl)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-[(4-methylsulfonylphenyl)methylsulfonyl]ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(2-phenylethylsulfonyl)ethyl]pyrimidine-2,4-diamine; isopropyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzoate; 1-[3-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]phenyl]guanidine 4-(2-(2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-ylamino)-1-hydroxyethyl)benzenesulfonamide; 6-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylsulfanyl]pyridine-3-sulfonamide; methyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylsulfanylmethyl]benzoate; 6-(3-chloro-2-methyl-phenyl)-N4-[2-[(5-methylisoxazol-3-yl)methylsulfanyl]ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(3,5-dimethylisoxazol-4-yl)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-propyl-pyrimidine-2,4-diamine; N4-butyl-6-(3-chloro-2-methyl-phenyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-(2-methoxyethyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-(3-ethoxypropyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-(tetrahydropyran-4-ylmethyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-(tetrahydrofuran-2-ylmethyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[(2E)-3,7-dimethylocta-2,6-dienyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-isobutyl-pyrimidine-2,4-diamine; methyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzoate; ethyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzoate; propyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzoate; 6-(3-chloro-2-methyl-phenyl)-N4-(2-phenylethyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(4-pyridyl)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(2-pyridyl)ethyl]pyrimidine-2,4-diamine; 2-hydroxyethyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzoate; 2-methylsulfonylethyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzoate; 2,3-dihydroxypropyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzoate; 6-(3-chloro-2-methyl-phenyl)-N4-[2-[(6-methylsulfonyl-3-pyridyl)amino]ethyl]pyrimidine-2,4-diamine; N-[4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylamino]-2-methyl-phenyl]acetamide; 6-(3-chloro-2-methyl-phenyl)-N4-[(2Z)-2-(fluoromethylene)-4-(4-fluorophenyl)butyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-N4-(2-((5-(methylsulfonyl)pyridin-2-yl)oxy)ethyl)pyrimidine-2,4-diamine; (2-(2-amino-6-(4-(methyl sulfonyl)phenethylamino)pyrimidin-4-yl)-6-chlorophenyl)methanol; methyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethylsulfinylmethyl]benzoate; 6-(3-chloro-2-methyl-phenyl)-N4-[2-[(5-methylisoxazol-3-yl)methylsulfinyl]ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(4-ethylphenyl)ethyl]pyrimidine-2,4-diamine; 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzene-1,2-diol 5-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl]benzene-1,2,3-triol 6-(3-chloro-2-methyl-phenyl)-N4-(2-methylallyl)pyrimidine-2,4-diamine; methyl 4-[2-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]ethyl sulfonylmethyl]benzoate; methyl 4-[[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]methyl]cyclohexanecarboxylate; 4-[4-[[2-amino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]amino]but-2-ynyl sulfanyl]benzoic acid; 6-(3-chloro-2-methyl-phenyl)-N4-[2-(3-pyridyl)ethyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-(2-pyrimidin-2-ylethyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methyl-phenyl)-N4-(2-pyrazin-2-ylethyl)pyrimidine-2,4-diamine; N4-[2-(4-bromophenyl)ethyl]-6-(3-chloro-2-methylphenyl)pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)-N-(1-hydroxypropan-2-yl)benzamide; 6-(3-chloro-2-methylphenyl)-4-N-{2-[4-(4-methylpiperazine-1-carbonyl)phenyl]ethyl}pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-N4-[2-(4-methanesulfinylphenyl)ethyl]pyrimidine-2,4-diamine; 4-[2-({2-amino-6-[2-methyl-3-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)ethyl]benzene-1-sulfonamide; N4-[2-(4-methanesulfonylphenyl)ethyl]-6-[2-methyl-3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-N4-(2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-N4-(2-{furo[3,2-c]pyridin-4-yloxy}ethyl)pyrimidine-2,4-diamine; 6-(3-chloro-2-methylphenyl)-N4-{2-[(5-chloropyridin-2-yl)oxy]ethyl}pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethoxy)benzonitrile; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethoxy)benzamide; 6-(3-chloro-2-methylphenyl)-N4-{2-[4-(2H-1,2,3,4-tetrazol-5-yl)phenoxy]ethyl}pyrimidine-2,4-diamine; 4-(2-(2-amino-6-(3-chloro-2-(hydroxymethyl)phenyl)pyrimidin-4-ylamino)ethyl)-benzenesulfonamide; (Z)-4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethoxy)-N\u2032-hydroxybenzene-1-carboximidamide; 6-(3-chloro-2-methylphenyl)-N4-[3-(4-methanesulfonylphenoxy)propyl]pyrimidine-2,4-diamine; 2-(3-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}propoxy)pyrimidine-4-carboxamide; 6-(3-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}propoxy)pyridine-3-carboxamide; 6-(3-chloro-2-methylphenyl)-N4-{2-[4-(morpholine-4-sulfonyl)phenyl]ethyl}pyrimidine-2,4-diamine; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)-N-(2-methoxyethyl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)-N-(oxetan-3-yl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)-N-(oxan-4-yl)benzene-1-sulfonamide; 4-(2-{[2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-yl]amino}ethyl)-N-methyl-N-(prop-2-yn-1-yl)benzamide; 6-(3-chloro-2-methylphenyl)-N4-[2-(4-ethynylphenyl)ethyl]pyrimidine-2,4-diamine; and 6-(2-(2-amino-6-(3-chloro-2-methylphenyl)pyrimidin-4-ylamino)ethoxy)pyridine-3-sulfonamide.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.08
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15447818', '14647400', '15899061', '15315461', '15315478']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8187707067402846
- 35 USC 102 Novelty (BERT): 0.5825195580563636
- Combined Prediction Score: 0.7951455918718925
- Mean Citation Score: 477.80761600000005
- Max Citation Score: 496.26343
- Similarity Product: 412.9479751214099

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- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test