PATENT CLAIM ANALYSIS

Application Number: 16062245
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "204100"]

Abstract:
Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof.

Claim (Index 3):
A process of purification of infectious virus particles, comprising the steps of:\n a) providing a crude harvest (a) comprising virus particles and impurities, wherein the impurities are generated from growing said virus particles on a cell substrate; b) reducing impurities from the crude harvest (a) by precipitation with an agent comprising protamine, preferably a protamine salt, more preferably a protamine sulphate, even more preferably a recombinant protamine sulphate, to obtain a virus preparation (b); c) further purifying the virus preparation (b) by an optimized sucrose density gradient centrifugation, wherein the optimized sucrose gradient is provided such that the protamine can be completely or almost completely separated from the virus fraction; and wherein the protamine concentration is reduced by this step to the extent that the protamine concentration in the final drug substance is below 1 \u03bcg/ml, preferably below 0.5 \u03bcg/mL, more preferably below 0.1 \u03bcg/mL, most preferably below 0.05 \u03bcg/mL.

Metadata:
- Claim Count in Document: 89.0
- Percentile: 94.0
- Lexical Diversity: 1.31034
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15781959', '16063007', '15212804', '15674585', '15674591']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7578814787899555
- 35 USC 102 Novelty (BERT): 0.6304235554946513
- Combined Prediction Score: 0.745135686460425
- Mean Citation Score: 441.864336
- Max Citation Score: 668.9586
- Similarity Product: 523.6203733857037

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test