PATENT CLAIM ANALYSIS

Application Number: 16068670
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["435", "006130"]

Abstract:
Practical assays to identify compounds that overcome the resistance of  M. tuberculosis  to bedaquiline are based on transcription factors Rv0324 and Rv0880 shown to mediate this resistance.

Claim (Index 4):
The method of  claim 3  which comprises:\n (a) providing a strain of MTB that has been modified to contain an expression system wherein a nucleotide sequence encoding said fluorescent protein is operably linked to said promoter; \n (b) treating a sample comprising said modified MTB with BDQ in the presence and absence of test compound; \n (c) measuring the fluorescence of a test sample which comprises said test compound and measuring fluorescence of a control sample which does not contain said test compound; and \n (d) comparing the level of fluorescence in the test sample as compared to the control sample \n whereby a test compound that results in diminished fluorescence of the test sample as compared to the control sample is identified as a compound that potentiates the treatment of tuberculosis with BDQ.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 95.0
- Lexical Diversity: 1.12
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['09949041', '10481563', '13000788', '15381901', '14527281']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5130879669846511
- 35 USC 102 Novelty (BERT): 0.4940503020812612
- Combined Prediction Score: 0.5111842004943121
- Mean Citation Score: 152.33914
- Max Citation Score: 159.17937
- Similarity Product: 99.63801967086911

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test