PATENT CLAIM ANALYSIS

Application Number: 15997643
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["435", "456000"]

Abstract:
The present invention provides methods and compositions for improving the efficacy of viral transduction of cells. More particularly, the present invention provides methods and materials useful for safely and reliably improving the efficiency of methods for transducing cells, such as human hematopoietic stern cells (HSC), with viruses and/or viral vectors. The compositions and methods are useful for therapeutic indications amenable to treatment with hematopoietic stem cell gene therapies.

Claim (Index 44):
The method of  claim 33 , wherein the lentivirus comprises: a) a left (5\u2032) HIV-1 LTR comprising a CMV promoter; b) a Psi packaging sequence (\u03a8+); c) an HIV-1 central polypurine tract/DNA flap (cPPT/FLAP); d) a rev response element (RRE); e) a \u03b2-globin promoter and a \u03b2-globin locus control region (LCR) operably linked to a gene of interest; and f) a right (3\u2032) lentiviral SIN LTR that comprises i) one or more insulator elements, or ii) a rabbit \u03b2-globin polyA (r\u03b2gpA) sequence.

Metadata:
- Claim Count in Document: 86.0
- Percentile: 94.0
- Lexical Diversity: 1.61702
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14348572', '13242815', '14125220', '14700021', '14488058']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6462937191228227
- 35 USC 102 Novelty (BERT): 0.6629502518942761
- Combined Prediction Score: 0.6479593723999681
- Mean Citation Score: 465.721416
- Max Citation Score: 657.55383
- Similarity Product: 640.6473851129206

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test