PATENT CLAIM ANALYSIS

Application Number: 16067444
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["544", "326000"]

Abstract:
Disclosed in the present invention are an acrylanilide compound represented by general formula (I) and a pharmaceutically acceptable salt thereof. The acrylanilide compound and the pharmaceutically acceptable salt thereof are used for treating clinical diseases by mainly acting on EGFR family casein kinases.

Claim (Index 1):
A compound of formula (I), or the pharmaceutically acceptable salts, solvates or prodrugs thereof: wherein: X, Y and R 1  are selected from any one of a), b) and c) below: a) when R 1  is \u2014NR 5 R 6 , X and Y are identical or different from each other, and are each independently selected from N and CR 4 ; b) when R 1  is selected from \u2014OR 5  and \u2014SR 5 , X and Y are identical or different from each other, and are each independently selected from N and CR 4 ; c) when R 1  is \u2014CR 5 R 6 , and when R 5  and R 6  form cycle with the carbon atoms attached to them, X is CR 4  and Y is N; R 2  is selected from the group consisting of alkoxy, alkylsulphanyl or NR 6 R 6 ; R 3  is selected from the group consisting of hydrogen, N(R y )(R z ), \u2014N(R v )R u N(R y )(R z ), \u2014OR u OR 6 , \u2014OR u N(R y )(R z ), \u2014SR 6  and \u2014SR u N(R y )(R z ); R 4  and R\u20324 are each selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, haloalkyl and cyano; R 5  and R 6  are each selected from any one of a), b) and c) below: a) R 5  is optionally substituted aryl group, optionally substituted heteroaryl or optionally substituted heterocyclyl; when substituted, the substituent is selected from 1-5 R 7  groups; wherein, each R 7  group is independently selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, amino, haloalkoxy, cycloalkyl, cycloalkylalkyl, hydroxylalkyl, haloalkyl, aryl, aryl alkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl; wherein the alkyl, alkenyl, alkynyl, alkoxy, amino, haloalkoxy, cycloalkyl, cycloalkylalkyl, hydroxylalkyl, haloalkyl, aryl, aryl alkyl, heterocyclyl or heteroaryl or heteroarylalkyl is optionally substituted with 1-5 groups selected from halogen, alkyl, alkenyl, alkynyl, aryl, hydroxyl, alkoxy, haloalkoxy, cycloalkyl, ester group and cyano; R 6  is selected from hydrogen and alkyl; b) R 5  and R 6  form heterocyclyl, heteroaryl or fused aromatic ring together with the nitrogen atoms attached to them, and the ring contains 0-4 heteroatoms independently selected from O, S and N; when substituted on the ring, the substituent is optionally 1-5 groups selected from halogen, haloalkyl, alkyl, alkenyl and cyano; c) R 5  and R 6  form a fused aromatic ring together with the carbon atoms attached to them, and the ring contains 0-4 heteroatoms independently selected from O, S and N; when substituted on the ring, the substituent is optionally 1-4 groups selected from halogen, haloalkyl, alkyl, alkenyl and cyano; R u  is each independently selected from the group consisting of alkylene, alkenylene and ynylene; R v  is selected from hydrogen and alkyl; R y  and R z  are each independently selected from the following a) or b): a) R y  and R z  are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxyalkyl, hydroxylalkyl, pyrrolidinyl, alkylamino or haloalkyl; b) R y  and R z  form heterocyclyl or heteroaryl together with the nitrogen atoms attached to them, and the ring contains 0-4 heteroatoms independently selected from O, S and N; the ring is optionally substituted with 1-4 groups selected from R 5  and R 7 .

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 1.30556
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11728897', '15745187', '12865339', '12755301', '13386645']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8554845719963113
- 35 USC 102 Novelty (BERT): 0.5549713347386649
- Combined Prediction Score: 0.8254332482705468
- Mean Citation Score: 420.294502
- Max Citation Score: 433.8232
- Similarity Product: 356.83118804984093

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test