PATENT CLAIM ANALYSIS

Application Number: 15884371
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["600", "431000"]

Abstract:
A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Flr meas  signal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DR ex meas  DR em , and DR em,filtered  signal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flr meas  signal within the post-equilibration portion of the measurement data set to an IF agent  signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium. The disclosed method includes removing the effects of leak-through of excitation-level light and removing the effects of autofluorescence from the Flr meas  signal.

Claim (Index 7):
A method of determining renal function in a patient, the method comprising:\n providing a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at a corresponding data acquisition time from a tissue of a patient before and after administration of an exogenous fluorescent agent, the at least two measurements comprising an Flr meas  signal detected at a third region adjacent to the diffuse reflecting medium by a filtered light detector during illumination of the diffuse reflecting medium by excitatory-wavelength light from the first region, and at least one DR signal selected from:\n a DR ex meas  signal detected at a second region adjacent to the diffuse reflecting medium by an unfiltered light detector during illumination of the diffuse reflecting medium by excitatory-wavelength light from a first region adjacent to the diffuse reflecting medium; \n a Flr meas  signal detected at a third region adjacent to the diffuse reflecting medium by a filtered light detector during illumination of the diffuse reflecting medium by excitatory-wavelength light from the first region; \n a DR em  signal detected at the second region by the unfiltered light detector during illumination of the diffuse reflecting medium by emission-wavelength light from the first position; and \n a DR em,filtered  signal detected at the third region by the filtered light detector during illumination of the diffuse reflecting medium by emission-wavelength light from the first position; and; \n transforming each Flr meas  signal of each measurement data entry within the post-equilibration portion of the measurement data set to an IF agent  signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the diffuse reflecting medium, wherein transforming each Flr meas  signal comprises removing the effects of leak-through of excitation-level light into the Flr meas  signal and removing the effects of autofluorescence from the Flr meas  signal; identifying a post-equilibration portion of the measurement data set; transforming a portion of the IF agent  signals corresponding to the post-equilibration portion of the measurement data set to a renal decay time constant (RDTC) by:\n log-transforming the portion of the IF agent  signals at each corresponding data acquisition time; \n performing a linear regression of the log-transformed IF agent  signals as a function of the corresponding data acquisition time to obtain a slope; \n inverting the slope to obtain the RDTC.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 86.0
- Lexical Diversity: 2.18667
- Patent Class: 600.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15884365', '12992040', '10779907', '14868369', '11254266']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4089562251382966
- 35 USC 102 Novelty (BERT): 0.5584103061704765
- Combined Prediction Score: 0.4239016332415146
- Mean Citation Score: 223.460134
- Max Citation Score: 466.13525
- Similarity Product: 381.81106027135246

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test