PATENT CLAIM ANALYSIS

Application Number: 16152226
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-01
Patent Classification: ["514", "001100"]

Abstract:
The present invention discloses a design for a molecular delivery vehicle capable of delivering a molecular payload to a target cell and its intracellular compartments. Also disclosed are highly pH-sensitive nanoconstruct that takes advantage of the requirement of cationic charge for internalization of CPPs to mask the non-specific internalization, compositions containing nanoconstruct, and methods for forming the same.

Claim (Index 20):
A method of delivering a biologically active agent to a targeted cell having a targeted acidic environment, comprising:\n attaching the biologically active agent to a peptide nanoconstruct to form a cell-targeted molecular agent; and contacting the cell-targeted molecular agent to a targeted cell so as to allow the cell-targeted molecular agent be internalized, thereby, delivering the biologically active agent, wherein said peptide nanoconstruct comprises a cell-targeting element operatively linked to a pH-sensitive masking element either directly or via a peptide linker, and wherein: said cell-targeting element comprises a cationic CPP, said pH-sensitive masking element comprises a pH-sensitive oligopeptide containing a histidine-glutamic acid repeat (HE) n , n=10-40, said glutamic acid is individually replaceable by aspartic acid D, and said peptide linker containing a peptide repeat having the general formula (GGGGS) n , n=3-6 or (G) n , n=4 to 8.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 97.0
- Lexical Diversity: 1.37778
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14648537', '15838164', '14112512', '13318032', '15032668']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7260284906662022
- 35 USC 102 Novelty (BERT): 0.500391307570783
- Combined Prediction Score: 0.7034647723566604
- Mean Citation Score: 244.26623200000003
- Max Citation Score: 249.67383
- Similarity Product: 181.92944303853747

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test