PATENT CLAIM ANALYSIS

Application Number: 16069824
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["506", "016000"]

Abstract:
The present invention relates to the field of microfluidics and in particular to analysing the gene expression of a cell in response to a ligand expressed in the same microfluidic compartment. By barcoding the transcriptome of the cell and of the expression system generating the ligand, the effect of the ligand on the cell expression can be discerned. The invention provides microfluidic compartments and methods for this purpose.

Claim (Index 1):
A plurality of microfluidic compartments, wherein at least 1% of said compartments form a subset in which each compartment comprises\n (i) a first cell, (ii) one second cell or one cell-free expression system expressing a polypeptide ligand intended to specifically bind to a molecule or part thereof accessible on the surface of the first cell, and (iii) a set of barcode oligonucleotides each comprising a barcode sequence unique to the set and a sequence capable of binding specifically to mRNA and/or cDNA.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 95.0
- Lexical Diversity: 1.7561
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15847752', '15980473', '14407849', '13899397', '14586857']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5592976588822004
- 35 USC 102 Novelty (BERT): 0.5079795426189398
- Combined Prediction Score: 0.5541658472558744
- Mean Citation Score: 272.0206380000001
- Max Citation Score: 275.86694
- Similarity Product: 191.0536234245384

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test