PATENT CLAIM ANALYSIS

Application Number: 15751163
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["546", "115000"]

Abstract:
The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases.

Claim (Index 4):
The compound of  claim 1 , R 1  is one of the following sub-formulae: wherein each X 1 , X 2 , X 3 , X 9  and X 10  is independently CH or N; each X 4 , X 5 , X 6 , X 7  and X is independently \u2014CH 2 \u2014, \u2014C(\u2550O)\u2014, \u2014O\u2014, \u2014S\u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 \u2014 or \u2014NH\u2014; R 1  is independently and optionally substituted with 1, 2, 3, 4 or 5 R 1a  which are the same or different; each R 1a  is independently H, C 1-4  alkyl, C 1-4  haloalkyl, halogen, cyano, oxo (\u2550O), C 1-4  alkoxy, \u2014SR 14 , \u2014OR 14 , \u2014SO 2 \u2014N(R 13 )(R 13a ), \u2014N(R 13a )\u2014SO 2 \u2014R 14 , \u2014N(R 13 )(R 13a ), \u2014C(\u2550O)\u2014C(\u2550O)\u2014N(R 13 )(R 13a ), \u2014C(\u2550O)\u2014N(R 13 )(R 13a ), \u2014C(\u2550N\u2014OH)(R 14a ), \u2014N(R 13 )\u2014C(\u2550O)R 14a , \u2014C(\u2550O)\u2014OR 14 , \u2014C(\u2550O)\u2014R 14a  or \u2014SO 2 R 14 , or one of the following sub-formulae: wherein each Y 1 , Y 2 , Y 3 , Y 9  and Y 10  is independently CH or N; each Y 4 , Y 5 , Y 6 , Y 7  and Y 8  is independently \u2014CH 2 \u2014, \u2014C(\u2550O)\u2014, \u2014O\u2014, \u2014S\u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 \u2014 or \u2014NH\u2014; each R 1a  in independently and optionally substituted with 1, 2, 3, 4 or 5 R 1b  which are the same or different; each R 1b  is independently H, C 1-4  alkyl, C 1-4  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  alkoxy, halogen, nitro, cyano, hydroxy, oxo (\u2550O), \u2014OR 15 , \u2014SO 2 R 15 , \u2014N(R 16 )(R 16a ), \u2014C(\u2550O)\u2014N(R 16 )(R 16a ), or one of the following sub-formulae: wherein each Z 1 , Z 2 , Z 3 , Z 9  and Z 10  is independently CH or N; each Z 4 , Z 5 , Z 6 , Z 7  and Z 8  is independently \u2014CH 2 \u2014, \u2014C(\u2550O)\u2014, \u2014O\u2014, \u2014S\u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 \u2014 or \u2014NH\u2014; each R 1b  is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from hydroxy, nitro, cyano, C 1-4  alkyl, C 1-4  haloalkyl, halogen, oxo (\u2550O), C 1-4  alkoxy, phenyl, 5- to 6-membered heteroaryl, 4- to 7-membered cycloalkyl, 4- to 7-membered heterocyclyl and amino; each R 16  and R 16a  is independently H, C 1-4  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 1-9  heteroaryl, C 3-6  cycloalkyl, \u2014SO 2 R 17 , \u2014N(R 18 )(R 18a ), C 1-4  haloalkyl or C 2-6  heterocyclyl; each R 15 , R 13 , R 13a , R 14 , R 14a , R 17 , R 18  and R 18a  is independently H, C 1-4  alkyl, C 1-4  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, phenyl, 5- to 6-membered heteroaryl, C 3-6  cycloalkyl or 4- to 6-membered heterocyclyl, wherein each of the phenyl, 5- to 6-membered heteroaryl, C 3-6  cycloalkyl and 4- to 6-membered heterocyclyl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from F, Cl, Br, cyano, hydroxy, trifluoromethyl, C 1-4  alkyl, C 1-4  alkoxy and 2,2-difluoroethyl.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.42222
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12734224', '14647445', '14397200', '15580978', '14894817']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8212321437730542
- 35 USC 102 Novelty (BERT): 0.5303103063067757
- Combined Prediction Score: 0.7921399600264264
- Mean Citation Score: 341.089354
- Max Citation Score: 366.94565
- Similarity Product: 278.68503877756

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test