PATENT CLAIM ANALYSIS

Application Number: 15898258
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-02
Patent Classification: ["514", "263400"]

Abstract:
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that modulate (e.g., agonizes or partially agonizes) NLRP3 that are useful, e.g., for treating a condition, disease or disorder in which an increase in NLRP3 signaling may correct a deficiency in innate immune activity (e.g., a condition, disease or disorder associated with an insufficient immune response) that contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Claim (Index 2):
The compound of  claim 1 , wherein the compound is of Formula (II): or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is independently unsubstituted C 1-6  alkyl, C(\u2550O)R a , \u2014C(\u2550O)OR a , \u2014S(O) 1-2 (R b ), \u2014S(O) 1-2 NR c R d , or \u2014C(\u2550O)NR c R d ; \n R 2  is independently H or unsubstituted C 1-6  alkyl; \n R 3  is: \n (i) H; \n (ii) unsubstituted C 1-2  alkyl; \n (iii) X\u2014R 8 , wherein X is an unbranched C 1-6  alkylene, and R 8  is \u2014OH, C 1-4  alkoxy, \u2014C 1-4  haloalkoxy, CO 2 R a , or \u2014CONR c R d ; \n (iv) (C 1-3  alkylene)-(C 6 -C 10  aryl), wherein the aryl is optionally substituted with from 1-3 substituents independently selected from C 1-6  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, and C 1-4  haloalkoxy; or \n (v) (C 1-3  alkylene)heteroaryl including from 5 to 6 ring atoms, wherein from 1 to 4 ring atoms are each independently selected from N, N(R e ), O, and S, and wherein the heteroaryl is optionally substituted with from 1 to 3 substituents independently selected from C 1-6  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, and C 1-4  haloalkoxy; \n R 4  and R 5  are each independently selected from: \n (i) H; \n (ii) halo; \n (iii) \u2014(C 0-3  alkylene)-C 3-10  cycloalkyl, wherein the cycloalkyl is optionally substituted with from 1 to 4 independently selected R f ; \n (iv) \u2014(C 0-3  alkylene)-heterocyclyl including from 3 to 10 ring atoms, wherein from 1 to 3 ring atoms are each independently selected from: N(R e ), O, and S, wherein the heterocyclyl is optionally substituted with from 1 to 4 R f ; \n (v) \u2014(C 0-3  alkylene)-(C 6 -C 10  aryl) optionally substituted with from 1 to 4 R g ; \n (vi) \u2014(C 0-3  alkylene)-heteroaryl including from 5 to 10 ring atoms, wherein from 1 to 4 ring atoms are each independently selected from: N, NHO, and S, wherein the heteroaryl is optionally substituted with from 1 to 3 R g ; \n (vii) C 1-6  alkyl optionally substituted with from 1-2 independently selected R h ; and \n (viii) \u2014(C 0-3  alkylene)-C 4-10  cycloalkenyl, wherein the cycloalkenyl is optionally substituted with from 1 to 2 R f ; \n R a  is: \n (i) C 1-6  alkyl optionally substituted with from 1 to 2 R h ; or \n (ii) \u2014(C 0-3  alkylene)-C 3-10  cycloalkyl, wherein the cycloalkyl is optionally substituted with from 1 to 2 R f ; \n (iii) \u2014(C 1-3  alkylene)-heterocyclyl including from 3 to 10 ring atoms, wherein from 1 to 3 ring atoms are each independently selected from N(R e ), O, and S, wherein the heterocyclyl is optionally substituted with from 1 to 4 independently selected R f ; \n (iv) \u2014(C 0-3  alkylene)-phenyl optionally substituted with from 1 to 4 independently selected R g ; or \n (v) \u2014(C 0-3  alkylene)-heteroaryl including from 5 to 10 ring atoms, wherein from 1 to 4 ring atoms are each independently selected from N, N(R e ), O, and S, wherein the heteroaryl is optionally substituted with from 1 to 3 independently selected R g ; \n R b  is C 1-6  alkyl; \n each occurrence of R c  and R d  is independently H or C 1-4  alkyl; \n each occurrence of R e  is independently H or C 1-4  alkyl; \n each occurrence of R f  is independently C 1-6  alkyl, C 1-4  haloalkyl, \u2014OH, F, Cl, C 1-4  alkoxy, C 1-4  haloalkoxy, cyano, or phenyl optionally substituted with from 1 to 4 R g ; \n each occurrence of R g  is independently halo, cyano, C 1-6  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, or C 1-4  haloalkoxy; and \n each occurrence of R h  is independently \u2014OH, F, C 1-4  alkoxy, C 1-4  haloalkoxy, or cyano.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.95588
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16093990', '16094000', '12813148', '15016841', '14982131']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7820727721178546
- 35 USC 102 Novelty (BERT): 0.5083330696979411
- Combined Prediction Score: 0.7546988018758634
- Mean Citation Score: 263.79211200000003
- Max Citation Score: 286.65015
- Similarity Product: 224.61457327333687

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test