PATENT CLAIM ANALYSIS

Application Number: 15742463
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "064000"]

Abstract:
Disclosed is a method of delivering therapeutic carbon monoxide to the cells and tissues of a patient which comprises administering thereto a compound of the formula XBY1Y2C(O)V (I) or pharmaceutically acceptable salts thereof. In addition, disclosed is a method of delivering a drug to a diseased cell or tissue by administering a compound of formula I either wherein at least one of X is a drug containing an amino group or V is a drug containing an amino group or hydroxyl group less a hydrogen on the amino or hydroxyl group. Further disclosed are novel compounds of Formula I.

Claim (Index 18):
A compound of the formula\n XBY1Y2C(O)V\u2003\u2003I or pharmaceutically acceptable salts, where each Y1 and Y2 may be the same or is different and is independently H, lower alkyl, halo, CN or C(O)V1; V is O \u2212 , OR1 or NR1R2 or is a first drug, which drug has an amino function or an alcohol moiety thereon in which a hydrogen atom of the alcohol or amine is not present; V1 is O \u2212 , OR10 or NR10R12 or is a third drug, which drug has an amino function or an alcohol moiety thereon in which a hydrogen atom of the alcohol or amine is not present; R1, R2, R10 and R12 are independently hydrogen, lower alkyl, aryl, aryl lower alkyl, cycloalkyl, cycloalkyl lower alkyl or Ar\u2014N(R3)C(O)R4 or is a first drug, which drug has an amino function or an alcohol moiety thereon in which a hydrogen atom of the alcohol or amine is not present; Ar is aryl; each R3 and R4 are independently hydrogen or lower alkyl; X is a second drug, which drug contains an amino group or X is a nitrogen containing vitamin, an amino acid, a nucleotide, or X is N(R5)(R6)(R7) or a nitrogen containing heterocyclic ring containing 1, 2, 3 or 4 nitrogen atoms, wherein one nitrogen atom is bonded directly to the boron atom, said nitrogen atom being bonded directly to the boron atom being tetravalent; R5, R6 and R7 are independently hydrogen, lower alkyl, cycloalkyl, cycloalkyl lower alkyl, aryl, aryl lower alkyl or heterocyclic or heterocyclic lower alkyl; wherein, aryl, heterocyclic, cycloalkyl, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 groups being independently unsubstituted or substituted with lower alkyl, halo, lower alkoxy, heterocyclic, cycloalkyl, nitro, carboxy, carbalkoxy, C(O)NR8R9, C(O)R8, or OC(O)R8, where R8 and R9 are independently hydrogen or lower alkyl, provided that X is not ammonia NH(CH 3 ) 2 , N(CH 3 ) 3  or nicotine when V is OH or O \u2212 , and further provided that either X is a drug or V is a drug having an amino or hydroxy group less a hydrogen atom on the amino or hydroxy group.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 86.0
- Lexical Diversity: 1.78689
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15317705', '12086792', '14156314', '12417672', '11402958']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7563442580800045
- 35 USC 102 Novelty (BERT): 0.4985737904994183
- Combined Prediction Score: 0.7305672113219459
- Mean Citation Score: 244.406484
- Max Citation Score: 249.671
- Similarity Product: 189.96527878421543

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test