PATENT CLAIM ANALYSIS

Application Number: 15766692
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "292000"]

Abstract:
The present invention relates to an acrylic acid derivative as shown in general formula (I), a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, the preparation method thereof, a pharmaceutical composition containing same, and the use thereof as therapeutic agents, in particular as selective estrogen receptor degraders (SERD), wherein the substituents of general formula (I) are the same as those defined in the description.

Claim (Index 7):
The compound, or the stereoisomer, tautomer or pharmaceutically acceptable salt thereof according to  claim 1 , wherein R 3  is selected from cyclopentyl or cyclohexyl, wherein said cyclopentyl or cyclohexyl is optionally further substituted by one or more groups selected from hydroxy, halogen, haloalkyl, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2014NR 5 R 6 , \u2014C(O)NR 5 R 6 , \u2014C(O)R 7 , \u2014SO 2 R 7 , \u2014C(O)OR 7  or \u2014NR 5 C(O)R 6 , wherein said cyclopentyl or cyclohexyl is preferably substituted by halogen, more preferably substituted by F; and\n wherein: R 5  is selected from hydrogen atom or alkyl; R 6  is selected from hydrogen atom, alkyl, cycloalkyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, aryl or heteroaryl is optionally further substituted by one or more groups selected from hydroxy, halogen, haloalkyl, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2014NR 8 R 9 , \u2014C(O)NR 8 R 9 , \u2014C(O)R 10 , \u2014SO 2 R 10 , \u2014C(O)OR 10  or \u2014NR 8 C(O)R 9 ; or, R 5  and R 6  together with the atoms attached to R 5  and R 6  form a 4- to 8-membered heterocyclyl, wherein said heterocyclyl is optionally further substituted by one or more groups selected from alkyl, halogen, hydroxy, cyano, nitro, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2014NR 8 R 9 , \u2014C(O)NR 8 R 9 , \u2014C(O)R 10 , \u2014SO 2 R 10 , \u2014C(O)OR 10  or \u2014NR 8 C(O)R 9 ; R 7  is selected from hydrogen atom, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted by one or more groups selected from hydroxy, halogen, haloalkyl, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2014NR 8 R 9 , \u2014C(O)NR 8 R 9 , \u2014C(O)R 10 , \u2014SO 2 R 10 , \u2014C(O)OR 10  or \u2014NR 8 C(O)R 9 ; and R 8 , R 9  and R 10  are each independently selected from hydrogen atom, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted by one or more groups selected from hydroxy, halogen, haloalkyl, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxy or carboxylate group.

Metadata:
- Claim Count in Document: 46.0
- Percentile: 91.0
- Lexical Diversity: 1.5098
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15736898', '15741639', '16302310', '15303704', '16061676']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8201526296181815
- 35 USC 102 Novelty (BERT): 0.5484998053577125
- Combined Prediction Score: 0.7929873471921346
- Mean Citation Score: 383.362046
- Max Citation Score: 404.6961
- Similarity Product: 354.9479943225503

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test