PATENT CLAIM ANALYSIS

Application Number: 16111842
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["544", "358000"]

Abstract:
Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC 50  value below 5 μM against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo, and led to 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.

Claim (Index 27):
A composition comprising a compound of  claim 19  and a pharmaceutically acceptable carrier, adjuvant, or vehicle.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 96.0
- Lexical Diversity: 1.45833
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15301188', '13302409', '14414669', '11883092', '15100967']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6940243083245062
- 35 USC 102 Novelty (BERT): 0.5579655116491838
- Combined Prediction Score: 0.6804184286569741
- Mean Citation Score: 256.96285
- Max Citation Score: 439.8415
- Similarity Product: 315.6473483355641

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test