PATENT CLAIM ANALYSIS

Application Number: 15746325
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["359", "385000"]

Abstract:
The invention relates to the high-resolution spectrally selective scanning microscopy of a sample. The sample is excited with illumination radiation in order to emit fluorescence radiation such that the illumination radiation is bundled into an illumination spot in or on the sample. The illumination spot is diffraction-limited in at least one spatial direction and has a minimum extension in said spatial direction. Fluorescence radiation emitted from the illumination spot is imaged into a diffraction image lying on an image plane in a diffraction-limited manner and is detected with a spatial resolution which resolves a structure of a diffraction image of the fluorescence radiation emitted from the illumination spot. The illumination spot is moved into different scanning positions relative to the sample in increments which are smaller than half the minimum extension of the illumination spot. An individual image of the structure of the diffraction image of the fluorescence radiation emitted from the illumination spot is generated for each scanning position, and an image of the sample is generated from the individual images, said image having a resolution which is increased over a resolution threshold of the imaging process. The fluorescence radiation emitted from the illumination spot is imaged into a diffraction image in a diffraction-limited manner onto a detector, said detector having an inlet surface with multiple adjacently lying local channels on the image plane. The local channels determine the spatial resolution with which the structure of the diffraction image of the fluorescence radiation emitted from the illumination spot is resolved, and the fluorescence radiation emitted from the illumination spot is spectrally evaluated. In precisely one first local channel of the adjacently lying local channels, the fluorescence radiation is guided onto a spectrometer and spectrally analyzed by means of the spectrometer, and in the remaining second local channels of the adjacently lying local channels, the fluorescence radiation is guided onto a respective detector element which detects solely the intensity of the fluorescence radiation.

Claim (Index 23):
A microscope for high-resolution spectrally selective scanning microscopy, comprising\n a sample space for receiving a sample which is excitable to emit fluorescent radiation, an optical unit which comprises a resolution limit and a focal plane, located in the sample space, an illumination device, which comprises an entrance for receiving illumination radiation and illuminates, via the optical unit, the sample space with illumination radiation such that the optical unit focuses illumination radiation to a point in the focal plane to form an illumination spot, which is diffraction-limited in at least one spatial direction and has, a minimum extent in this spatial direction, an imaging device for diffraction-limited imaging of fluorescent radiation coming from the illumination spot in the focal plane through the optical unit and into a diffraction image on a spatially resolving detector which is located in an image plane that is conjugate to the focal plane,\n wherein the surface detector has a plurality of adjacent location channels which define a spatial resolution at which the structure of the diffraction image of the fluorescent radiation coming from the illumination spot is resolved, \n wherein the spatial resolution resolves a structure of the diffraction image, \n wherein exactly one first of the location channels guides the fluorescent radiation onto a spectrometer spectral evaluation, and \n wherein each remaining location channel guides the fluorescent radiation onto an individual detector element, which does not perform spectral evaluation and captures the fluorescent radiation only with respect to the intensity in the assigned remaining location channel, \n a scanning device for displacing the point into different scanning positions at an increment size of less than half the minimum extent of the illumination spot, and an evaluation device for reading the detector, for evaluating the diffraction structure of the diffraction image from individual image data of the surface detector and from the scanning position is assigned to said individual image data, and for producing an image of the sample that has a resolution that is increased to above the resolution limit.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 86.0
- Lexical Diversity: 3.19811
- Patent Class: 359.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15764238', '14373602', '15457486', '14490806', '14457833']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8209184757088798
- 35 USC 102 Novelty (BERT): 0.5337236960845878
- Combined Prediction Score: 0.7921989977464506
- Mean Citation Score: 312.2490380000001
- Max Citation Score: 398.87204
- Similarity Product: 391.2881244216538

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test