PATENT CLAIM ANALYSIS

Application Number: 16304634
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-09
Patent Classification: ["540", "575000"]

Abstract:
Relating to processes for preparing suvorexant or its pharmaceutically acceptable salts through the formation of a cocrystal of (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate hydrochloride with (R)-(+)-1,1,2-triphenyl-1,2-ethanediol ((R)-TED). This cocrystal provides the resolution of an intermediate of suvorexant, in particular, of (rac)-benzyl5-methyl-1,4-diazepane-1-carboxy-lateor a hydrochloride salt thereof. It also relates to a new cocrystal useful in such preparation processes.

Claim (Index 10):
The resolution process according to  claim 9 , wherein the dissociation step comprises:\n (1) slurrying the cocrystal of (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate hydrochloride with (R)-TED of formula (II), in water between 0\u00b0 C. and room temperature; (2) separating the (R)-TED from the medium; and (3) basifying the aqueous phase, extracting the (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate of formula (R)-(III) with an appropriate organic solvent; optionally isolating the (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate of formula (R)-(III) as a free base, and if desired converting the free base into a salt thereof by addition of the corresponding acid.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 98.0
- Lexical Diversity: 1.60417
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16073929', '15501295', '12061499', '13147337', '10536618']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6552859154761083
- 35 USC 102 Novelty (BERT): 0.5257623938914728
- Combined Prediction Score: 0.6423335633176447
- Mean Citation Score: 238.975446
- Max Citation Score: 276.726
- Similarity Product: 178.4493055279255

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test