PATENT CLAIM ANALYSIS

Application Number: 15899561
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "252030"]

Abstract:
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R 1  and R 2  are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Claim (Index 26):
The method according to  claim 17 , wherein the compound of formula (I) is chosen from:\n 4-Hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one, 6-[2-(4-Fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 4-Hydroxy-6-{2-[5-(trifluoromethyl)pyridin-2-yl]ethyl}pyridazin-3(2H)-one, 6-[(4-Chlorobenzyl)sulfanyl]-4-hydroxypyridazin-3(2H)-one, 4-Hydroxy-6-{2-[6-(trifluoromethyl)pyridin-3-yl]ethyl}pyridazin-3(2H)-one, 6-[2-(3-Fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 6-[2-(2-Fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 6-[2-(3,5-Difluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 6-[2-(3,4-Difluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 4-Hydroxy-6-{2-[3-(trifluoromethoxy)phenyl]ethyl}pyridazin-3(2H)-one, 4-Hydroxy-6-{2-[3-(trifluoromethyl)phenyl]ethyl}pyridazin-3(2H)-one, 4-Hydroxy-6-{2-[5-(trifluoromethyl)pyridine-3-y]ethyl}pyridazin-3(2H)-one, 6-(2-Cyclohexylethyl)-4-hydroxypyridazin-3(2H)-one, 6-(2-Cyclopropylethyl)-4-hydroxypyridazin-3(2H)-one, 6-(2-Cyclopentylethyl)-4-hydroxypyridazin-3(2H)-one, 4-Hydroxy-6-[2-(4-methoxycyclohexyl)ethyl]pyridazin-3(2H)-one, 6-[2-(2,4-Difluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 6-{2-[3-(Difluoromethyl)phenyl]ethyl}-4-hydroxypyridazin-3(2H)-one, 6-Benzyl-4-hydroxypyridazin-3(2H)-one, 6-[2-(3-Chlorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 4-Hydroxy-6-(1-phenylcyclopropyl)pyridazin-3(2H)-one, 4-[2-(5-Hydroxy-6-oxo-1,6-dihydropyridazin-3-yl)ethyl]benzonitrile, 6-[2-(3-Fluoro-4-methylphenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 6-[2-(4-Fluoro-3-methylphenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 6-[2-(3,4-Dimethoxyphenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 4-Hydroxy-6-{2-[3-(trifluoromethoxy)phenyl]ethyl}pyridazin-3(2H)-one, 6-[2-(4-Chlorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 6-[2-(2-Chlorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 4-Hydroxy-6-{2-[2-(trifluoromethyl)phenyl]ethyl}pyridazin-3(2H)-one, 6-(4-(Difluoromethoxy)phenethyl)-4-hydroxypyridazin-3(2H)-one, 6-(4-(Trifluoromethoxy)phenethyl)-4-hydroxypyridazin-3(2H)-one, 6-(3-(Difluoromethoxy)phenethyl)-4-hydroxypyridazin-3(2H)-one, 6-[1-(4-Fluorophenyl)cyclopropyl]-4-hydroxypyridazin-3(2H)-one, 6-[1-(4-Fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one, 4-Hydroxy-6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyridazin-3(2H)-one, 4-Hydroxy-6-{2-[4-(trifluoromethyl)phenyl]ethyl}pyridazin-3(2H)-one, 6-((Cyclopropylmethyl)(methyl)amino)-4-hydroxypyridazin-3(2H)-one, 6-((Cyclohexylmethyl)(methyl)amino)-4-hydroxypyridazin-3(2H)-one, 6-(3-Chlorobenzyl)-4-hydroxypyridazin-3(2H)-one, 6-(4-Chlorobenzyl)-4-hydroxypyridazin-3(2H)-one, 6-(Cyclohexylmethyl)-4-hydroxypyridazin-3(2H)-one, 6-(4-Fluorobenzyl)-4-hydroxypyridazin-3(2H)-one, 6-(2-Chloro-6-fluorobenzyl)-4-hydroxypyridazin-3(2H)-one, 6-(2-Chlorobenzyl)-4-hydroxypyridazin-3(2H)-one, 6-(3 -Fluorobenzyl)-4-hydroxypyridazin-3 (2H)-one, 6-(2-Fluorobenzyl)-4-hydroxypyridazin-3(2H)-one, 6-(4-Methylbenzyl)-4-hydroxypyridazin-3(2H)-one, 6-(3 -Methylbenzyl)-4-hydroxypyridazin-3 (2H)-one, 4-Hydroxy-6-(3-(trifluoromethyl)benzyl)pyridazin-3(2H)-one, 4-Hydroxy-6-{2-[5-(trifluoromethyl)pyridin-3-yl]ethyl}pyridazin-3(2H)-one, 4-Hydroxy-6-[2-(oxan-4-yl)ethyl]pyridazin-3(2H)-one, 6-{[(4-Fluorophenyl)methyl](methyl)amino}-4-hydroxy-pyridazin-3(2H)-one, 6-[2-(2,6-Difluorophenyl)ethyl]-4-hydroxy-pyridazin-3(2H)-one, 6-[2-(2-Chloro-6-fluorophenyl)ethyl]-4-hydroxy-pyridazin-3(2H)-one, 6-{[3,5-bis(Trifluoromethyl)phenyl]methyl}-4-hydroxypyridazin-3 (2H)-one, 6-(1-Phenyl ethyl)-4-hydroxypyridazin-3(2H)-one, 6-(Cyclopropylmethyl)-4-hydroxy-2,3-dihydropyridazin-3-one, 4-Hydroxy-6-{l-[4-(trifluoromethyl)phenyl]cyclopropyl}-2,3-dihydropyridazin- 3-one, 6-{2-[2-Chloro-4-(trifluoromethyl)phenyl]ethyl}-4-hydroxy-2,3-dihydropyridazin-3-one, 6-{ 2-[2-Fluoro-4-(trifluoromethyl)phenyl]ethyl} -4-hydroxy-2,3 -dihydropyridazin-3-one, 6-{2-[3,5-bis(Trifluoromethyl)phenyl]ethyl}-4-hydroxy-2,3-dihydropyridazin-3-one, 6-{2-[2,4-bis(Trifluoromethyl)phenyl]ethyl}-4-hydroxy-2,3-dihydro-pyridazin-3-one, 6-{2-[3,4-bis(Trifluoromethyl)phenyl]ethyl}-4-hydroxy-2,3-dihydropyridazin-3-one, 4-Hydroxy-6-(3-methyl-4-(trifluoromethyl)phenethyl)pyridazin-3(2H)-one, 3,4-bis(Benzyloxy)-6-((3-chloro-4-(trifluoromethyl)phenyl)ethyl)-pyridazine, 4-Hydroxy-6-{2-[2-methyl-4-(trifluoromethyl)phenyl]ethyl}-2,3-dihydropyridazin-3-one, 6-{2-[3,5-Difluoro-4-(trifluoromethyl)phenyl]ethyl}-4-hydroxy-2,3 -dihydropyridazin-3-one, 6-{2-[3-Fluoro-4-(trifluoromethyl)phenyl]ethyl}-4-hydroxy-2,3-dihydropyridazin-3-one, and a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 88.0
- Lexical Diversity: 1.18919
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14240045', '15014336', '14652484', '12739262', '10578594']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8239094825151094
- 35 USC 102 Novelty (BERT): 0.5929146026888734
- Combined Prediction Score: 0.8008099945324858
- Mean Citation Score: 406.878576
- Max Citation Score: 509.31485
- Similarity Product: 449.5196521119743

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test