PATENT CLAIM ANALYSIS

Application Number: 15770074
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "303000"]

Abstract:
Disclosed in the present application is a compound of formula (I) as defined herein as well as a pharmaceutical composition comprising said compound. Further disclosed in the present application is the use of such pharmaceutical compositions for treating diseases, namely inter alia for use in the treatment of cancer, metabolic, inflammatory, autoimmune and viral diseases. The compounds disclosed herein are inhibitors of MNK1 and/or MNK2 kinases.

Claim (Index 12):
The compound according to  claim 1 , wherein said compound is selected from the group consisting of 1-benzyl-5-(1H-indazol-6-yl)-1,2-dihydropyridin-2-one; 1-(2-fluorobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 2-{[5-(1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}benzonitrile; 1-(1,3-benzodioxol-5-ylmethyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-(2-chlorobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-(4-methoxybenzyl)pyridin-2(1H)-one; 1-(3,4-dichlorobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-(3-methoxybenzyl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-(3-nitrobenzyl)pyridin-2(1H)-one; 1-(4-fluoro-3-nitrobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-(pyridin-2-ylmethyl)pyridin-2(1H)-one; 1-(3-chlorobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[(2-methyl-1,3-thiazol-5-yl)methyl]pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[4-(trifluoromethyl)benzyl]pyridin-2(1H)-one; methyl 3-{[5-(1H-indazol-6-yl)-2-oxopyridin-1 (2H)-yl]methyl}benzoate; methyl 2-{[5-(1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}benzoate; 5-(1H-indazol-6-yl)-1-(pyridin-4-ylmethyl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[2-(trifluoromethyl)benzyl]pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[3-(trifluoromethyl)benzyl]pyridin-2(1H-)-one; 3-{[5-(1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}benzonitrile; 3-{[5-(1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}benzamide; 5-(1H-indazol-6-yl)-1-(1-phenylethyl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[2-(trifluoromethoxy)benzyl]pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[2-(thiophen-2-yl)benzyl]pyridin-2(1H)-one; 1-[3-(difluoromethoxy)benzyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-[(5-chlorothiophen-2-yl)methyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[2-(pyridin-4-yl)benzyl]pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[2-(pyridin-3-yl)benzyl]pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-(1H-pyrazol-4-ylmethyl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[3-(thiophen-2-yl)benzyl]pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[3-(pyridin-3-yl)benzyl]pyridin-2(1H)-one; 4-{[5-(1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}benzonitrile; 1-[3-(hydroxymethyl)benzyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-[(4-bromothiophen-2-yl)methyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-(thiophen-3-ylmethyl)pyridin-2(1H)-one; 1-[2-(hydroxymethyl)benzyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-[2-(furan-3-yl)benzyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[2-(thiophen-3-yl)benzyl]pyridin-2(1H)-one; 1-[(2-chloropyridin-4-yl)methyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-[2-(1H-pyrazol-3-yl)benzyl]pyridin-2(1H)-one; 1-(3-chloro-4-fluorobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-(3-chlorobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-(2-fluoro-3-nitrobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-(5-fluoro-2-nitrobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-(3-fluoro-2-nitrobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-[5-chloro-2-(thiophen-3-yl)benzyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-(2-ethenylbenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-(tetrahydro-2H-pyran-4-ylmethyl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(2-fluorobenzyl)pyridin-2(1H)-one; 1-benzyl-5-(3-bromo-1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-(2-nitrobenzyl)pyridin-2(1H)-one; 1-(cyclopropylmethyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(1H-indazol-6-yl)-1-(pyridin-3-ylmethyl)pyridin-2(1H)-one; 1-(cyclohexylmethyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-benzyl-5-(4-nitro-1H-indazol-6-yl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-benzylpyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(3-chlorobenzyl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-[2-(trifluoromethyl)benzyl]pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-[3-(trifluoromethyl)benzyl]pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(1-phenylethyl)pyridin-2(1H)-one; 5-(3-amino-5-methyl-1H-indazol-6-yl)-1-benzylpyridin-2(1H)-one; 1-benzyl-5-(1H-pyrazolo[4,3-c]pyridin-6-yl)pyridin-2(1H)-one; 1-benzyl-5-(3-hydroxy-1H-indazol-6-yl)pyridin-2(1H)-one; N-[6-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-indazol-3-yl]acetamide; 1-benzyl-5-(3-methyl-1H-indazol-6-yl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-[(5-chlorothiophen-2-yl)methyl]pyridin-2(1H)-one; 1-benzyl-5-(5-nitro-1H-indazol-6-yl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(thiophen-3-ylmethyl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-[2-(thiophen-2-yl)benzyl]pyridin-2(1H)-one; N-(3-{[5-(3-amino-1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}phenyl)acetamide; 5-(3-amino-1H-indazol-6-yl)-1-(3-fluorobenzyl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(2-fluoro-3-nitrobenzyl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(5-fluoro-2-nitrobenzyl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(3-chloro-4-fluorobenzyl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(3-fluoro-2-nitrobenzyl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-[5-chloro-2-(thiophen-3-yl)benzyl]pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(2-ethenylbenzyl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(2-ethenylbenzyl)pyridin-2(1H)-one; 5-(4-amino-1H-indazol-6-yl)-1-benzylpyridin-2(1H)-one; 1-benzyl-5-[3-(pyridin-4-yl)-1H-indazol-6-yl]pyridin-2(1H)-one; 1-benzyl-5-[3-(4-hydroxyphenyl)-1H-indazol-6-yl]pyridin-2(1H)-one; 1-benzyl-5-[3-(3-methoxyphenyl)-1H-indazol-6-yl]-1,2-dihydropyridin-2-one; 1-benzyl-5-[3-(3-methylphenyl)-1H-indazol-6-yl]-1,2-dihydropyridin-2-one; N-(3-{[5-(3-amino-1H-indazol-6-yl)-2-oxo-1,2-dihydropyridin-1-yl]methyl}phenyl)-2-fluoroacetamide; N-(3-{[5-(3-amino-1H-indazol-6-yl)-2-oxo-1,2-dihydropyridin-1-yl]methyl}-4-fluorophenyl)acetamide; N-(2-{[5-(3-amino-1H-indazol-6-yl)-2-oxo-1,2-dihydropyridin-1-yl]methyl}phenyl)acetamide; N-(3-{[5-(3-amino-1H-indazol-6-yl)-2-oxo-1,2-dihydropyridin-1-yl]methyl}-2-fluorophenyl)acetamide; 2-{[5-(3-amino-1H-indazol-6-yl)-2-oxo-1,2-dihydropyridin-1-yl]methyl}benzene-1-sulfonamide; 1-[2-(bromomethyl)benzyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-[3-(bromomethyl)benzyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 1-(3-hydroxybenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one; 5-(3-amino-1H-indazol-6-yl)-1-(3-hydroxybenzyl)pyridin-2(1H)-one; 2-{[5-(1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}benzamide; 1-{4-[(2-aminoethyl)amino]-3-nitrobenzyl}-5-(1H-indazol-6-yl)pyridin-2(1H)-one hydrochloride; 1-(3-aminobenzyl)-5-(1H-indazol-6-yl)pyridin-2(1H)-one hydrochloride; 1-[(6-aminopyridin-2-yl)methyl]-5-(1H-indazol-6-yl)pyridin-2(1H)-one hydrochloride; 3-amino-N-(3-{[5-(1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}phenyl)propanamide hydrochloride; 5-[3-amino-4-({[(1R,4R)-4-aminocyclohexyl]methyl}amino)-1H-indazol-6-yl]-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one hydrochloride; tert-butyl 4-{[(3-amino-6-{1-[(3-chlorophenyl)methyl]-6-oxo-1,6-dihydropyridin-3-yl}-1H-indazol-4-yl)amino]methyl}piperidine-1-carboxylate hydrochloride; 5-[3-amino-4-(piperidin-4-ylmethoxy)-1H-indazol-6-yl]-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one hydrochloride; 5-{3-amino-4-[(pyrrolidin-3-ylmethyl)amino]-1H-indazol-6-yl}-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one hydrochloride; 5-{3-amino-4-[(piperidin-4-yl)amino]-1H-indazol-6-yl}-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one hydrochloride; N-(3-{[5-(1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}phenyl)acetamide; N-(3-{[5-(1H-indazol-6-yl)-2-oxopyridin-1(2H)-yl]methyl}phenyl)prop-2-enamide; (2Z)-4-(dimethylamino)-N-(2-{[5-(1H-indazol-6-yl)-2-oxo-1,2-dihydropyridin-1-yl]methyl}phenyl)but-2-enamide; 1-(2-aminobenzyl)-5-(1H-indazol-6-yl)pyridin-2 (1H)-one; 5-(5-amino-1H-indazol-6-yl)-1-benzylpyridin-2(1H)-one; 5-{3-amino-4-[(oxan-4-ylmethyl)amino]-1H-indazol-6-yl}-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one; 5-{3-amino-4-[(oxolan-3-ylmethyl)amino]-1H-indazol-6-yl}-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one; 5-(4-{[(1-acetylpiperidin-4-yl)methyl]amino}-3-amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one; N-[3-({5-[3-amino-4-(oxan-4-ylmethoxy)-1H-indazol-6-yl]-2-oxo-1,2-dihydropyridin-1-yl}methyl)phenyl]acetamide; 5-(4-{[(1-acetylpiperidin-3-yl)methyl]amino}-3-amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one; and 5-[3-amino-4-(oxan-4-ylmethoxy)-1H-indazol-6-yl]-1-[(3-chlorophenyl)methyl]-1,2-dihydropyridin-2-one, or a salt, stereoisomer, tautomer or N-oxide thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 91.0
- Lexical Diversity: 1.53061
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14386313', '12991225', '13681230', '15677614', '13891961']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.833951992831665
- 35 USC 102 Novelty (BERT): 0.5306667538231232
- Combined Prediction Score: 0.8036234689308108
- Mean Citation Score: 340.981962
- Max Citation Score: 364.35355
- Similarity Product: 261.0548173887372

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test