PATENT CLAIM ANALYSIS

Application Number: 16091764
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["564", "415000"]

Abstract:
A process for preparation of 4-aminoindane derivatives of a first formula, salts and enantiomers thereof comprising the steps of: a) hydrogenating a 1,2-dihydroquinoline of a second formula to give a corresponding tetrahydroquinoline of a third formula; b) acylating the tetrahydroquinoline of the third formula with a carboxylic acid derivative of a fourth formula to obtain a corresponding acyl derivative compound of a fifth formula; c) rearranging the acyl derivative compound of the fifth formula under acidic conditions so as to give an acyl indane compound of a sixth formula; and d) hydrolysing the acyl group of the acyl indane compound of the sixth formula so as to obtain the 4-aminoindane derivatives of the first formula.

Claim (Index 1):
A process for preparation of 4-aminoindane derivatives of Formula (I), salts and enantiomers thereof comprising the steps of: a) hydrogenating a 1,2-dihydroquinoline of Formula (IV) to give a corresponding tetrahydroquinoline of Formula (V) b) acylating the tetrahydroquinoline of Formula (V) with a carboxylic acid derivative of Formula RC(O)LG to obtain a corresponding acyl derivative compound of Formula (VI) c) rearranging the acyl derivative compound of Formula (VI) under acidic conditions so as to give an acyl indane compound of Formula (VII) and\n d) hydrolysing the acyl group of the acyl indane compound of Formula (VII) so as to obtain the 4-aminoindane derivatives of Formula (I); \n wherein in the formulae:\n n is an integer selected within the range from 0 to 3, inclusive; \n R is selected from a C 1 -C 6  alkyl group or a C 6 -C 10  aryl group, these groups being optionally substituted with one or more of: C 1 -C 6  alkyl groups, halogen atoms; and \n LG is a leaving group selected from: (i) a hydroxy group; (ii) a halogen atom; (iii) a C 1 -C 6  alkylsulfonyloxy group; (iv) a C 6 -C 10  arylsulfonyloxy group; (v) a R a COO group wherein R a  is a C 1 -C 6  alkyl group, the groups (iii)-(v) being optionally substituted with one or more halogen atoms.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 97.0
- Lexical Diversity: 2.31481
- Patent Class: 564.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15117058', '12295618', '13933961', '14768082', '11874218']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6920601713447336
- 35 USC 102 Novelty (BERT): 0.4963615045032973
- Combined Prediction Score: 0.67249030466059
- Mean Citation Score: 174.69682
- Max Citation Score: 177.10905
- Similarity Product: 130.740603828603

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test