PATENT CLAIM ANALYSIS

Application Number: 16080428
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["435", "007100"]

Abstract:
Provided are methods of detecting and quantitatively measuring protein-protein interactions between proteins present on the surface of different cells using a sensitive antibody-based assay. Antibodies specific for each target protein are either directly labeled, or are detected by labeled secondary antibodies. The antibodies are labeled with detectable tags that are releasable when the target proteins are within proximity to each other. Also provided are methods for facilitating diagnosis, prognosis, and treatment of cancer using this assay to detect protein-protein interactions between target proteins of interest. Methods of screening test agents that impact the protein-protein interaction are also provided.

Claim (Index 41):
A method of screening test agents for the ability to disrupt or promote formation of a protein-protein interaction between two cells in a sample, the method comprising:\n (a) contacting a test cell culture with a test agent, the test cell culture comprising a first cell expressing a first protein on its cell surface and a second cell expressing a second protein on its cell surface; (b) measuring the amount of protein-protein interaction between the first protein and the second protein using the method of  claim 3 ; and (c) comparing the amount of protein-protein interaction measured in step (b) to the amount of protein-protein interaction measured between the first protein and the second protein in a control cell culture not contacted with the test agent, the control cell culture comprising the first cell expressing the first protein on its cell surface and the second cell expressing the second protein on its cell surface.

Metadata:
- Claim Count in Document: 40.0
- Percentile: 96.0
- Lexical Diversity: 1.58209
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12688798', '15663136', '15767801', '14802170', '15588271']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.557883305570679
- 35 USC 102 Novelty (BERT): 0.5207505933987409
- Combined Prediction Score: 0.5541700343534852
- Mean Citation Score: 283.6257260000001
- Max Citation Score: 293.78473
- Similarity Product: 191.6711865445376

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test