PATENT CLAIM ANALYSIS

Application Number: 15770369
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-01
Patent Classification: ["514", "255050"]

Abstract:
Described are methods of use of compounds that inhibit PIF-mediated substrate binding by PDK1, which are useful as inhibitors of cancer growth or proliferation that is RSK2-dependent or AKT-independent. Also described are compositions of such compounds for use in such methods of treating cancer.

Claim (Index 2):
The method of  claim 1 , in which the compound is of Formula Is:\n or a pharmaceutically acceptable salt thereof, in which: or a pharmaceutically acceptable salt thereof, in which: any substitutable carbon on Ring A 4  is optionally substituted with R 3 , R 4 , or R 5 , and any substitutable nitrogen on Ring A 4  is optionally substituted with R 6 ; each of R 3 , R 4 , and R 5  is\n independently \u2014R, -halo, \u2014NO 2 , \u2014CN, \u2014OR, \u2014SR, \u2014N(R\u2032) 2 , \u2014C(O)R, \u2014CO 2 R, \u2014C(O)C(O)R, \u2014C(O) CH 2 C(O)R, \u2014S(O)R, \u2014S(O) 2 R, \u2014C(O)N(R\u2032) 2 , \u2014S(O) 2 N(R\u2032) 2 , \u2014OC(O)R, \u2014N(R\u2032)C(O)R, \u2014N(R\u2032)N(R\u2032) 2 , \u2014N(R\u2032)OR, \u2014N(R\u2032)C(\u2550NR\u2032)N(R\u2032) 2 , \u2014C(\u2550NR\u2032)N(R\u2032) 2 , \u2014C\u2550NOR, \u2014N(R\u2032)C(O)N(R\u2032) 2 , \u2014N(R\u2032)S(O) 2 N(R\u2032) 2 , \u2014N(R\u2032)S(O) 2 R, or \u2014OC(O)N(R\u2032) 2 ; or: \n R 3  and R 4  or R 4  and R 5  are taken together with their intervening atoms to form an optionally substituted fused ring selected from a 4-7 membered partially unsaturated carbocyclic ring, phenyl, a 5-6 membered partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; \n each R 6  is independently \u2014R, \u2014C(O)R, \u2014CO 2 R, \u2014C(O)C(O)R, \u2014C(O)CH 2 C(O)R, \u2014S(O)R, \u2014S(O) 2 R, \u2014C(O)N(R\u2032) 2 , or \u2014S(O) 2 N(R\u2032) 2 ; or: \n R 3  and R 6  are taken together with their intervening atoms to form an optionally substituted fused ring selected from a 5-6 membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; \n R 7  is hydrogen or methyl; and \n each R 8  is independently hydrogen or halo.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 91.0
- Lexical Diversity: 1.42424
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14966821', '10949714', '10350806', '13124773', '10922575']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8288869663310277
- 35 USC 102 Novelty (BERT): 0.5504827215615485
- Combined Prediction Score: 0.8010465418540798
- Mean Citation Score: 397.804354
- Max Citation Score: 416.61884
- Similarity Product: 336.3734276595068

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test