PATENT CLAIM ANALYSIS

Application Number: 15781182
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "450000"]

Abstract:
Disclosed is a method for preparing a composition for an anionic drug delivery with increased production yield, comprising forming nanoparticles by using electrostatic interaction of an anionic drug and a cationic compound in an aqueous phase; and incorporating the nanoparticles into polymeric micelles comprising an amphiphilic polymer and optionally a polylactic acid salt to increase the electrostatic interaction and hydrophobic binding, thereby increasing the entrapment efficiency of the anionic drug in the formulation.

Claim (Index 12):
The method of  claim 2 , wherein the polylactic acid salt is at least one selected from the group consisting of the compounds represented by Chemical Formulae 2 to 7:\n RO\u2014CHZ-[A] n -[B] m \u2014COOM \u2003\u2003[Chemical Formula 2] in the formula 2, A is \u2014COO\u2014CHZ\u2014; B is \u2014COO\u2014CHY\u2014, \u2014COO\u2014CH 2 CH 2 CH 2 CH 2 CH 2 \u2014 or \u2014COO\u2014CH 2 CH 2 OCH 2 ; R is a hydrogen, an acetyl, benzoyl, decanoyl, palmitoyl, methyl, or ethyl group; Z and Y are independently a hydrogen, a methyl or phenyl group; M is Na, K, or Li; n is an integer of 1 to 30; and m is an integer of 0 to 20;\n RQ\u2014CHZ\u2014[COO\u2014CHX] p \u2014[COO\u2014CHY\u2032] q \u2014COO\u2014CHZ\u2014COOM \u2003\u2003[Chemical Formula 3] \n in the formula 3, X is a methyl group; Y\u2032 is a hydrogen or a phenyl group; p is an integer of 0 to 25 and q is an integer of 0 to 25, with a proviso that p+q is an integer of 5 to 25; R is a hydrogen, an acetyl, benzoyl, decanoyl, palmitoyl, methyl or ethyl group; M is Na, K, or Li; Z is a hydrogen, a methyl or phenyl group;\n RO\u2014PAD-COO\u2014W-M\u2032\u2003\u2003[Chemical Formula 4] \n in the formula 4, W-M\u2032 is PAD is selected from the group consisting of D,L-polylactic acid, D-polylactic acid, polymandelic acid, a copolymer of D,L-lactic acid and glycolic acid, a copolymer of D,L-lactic acid and mandelic acid, a copolymer of D,L-lactic acid and caprolactone, and a copolymer of D,L-lactic acid and 1,4-dioxan-2-one; R is a hydrogen, a acetyl, benzoyl, decanoyl, palmitoyl, methyl or ethyl group; M is independently Na, K, or Li;\n S\u2014O\u2014PAD-COO-Q \u2003\u2003[Chemical Formula 5] \n in the formula 5, S is \n L is \u2014NR 1 \u2014 or \u2014O\u2014, herein R 1  is a hydrogen or C 1-10  alkyl; Q is CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH 2 CH 2 CH 2 CH 3 , or CH 2 C 6 H 5 ; a is an integer of 0 to 4; b is an integer of 1 to 10; M is Na, K, or Li; PAD is at least one selected from the group consisting of D,L-polylactic acid, D-polylactic acid, polymandelic acid, a copolymer of D,L-lactic acid and glycolic acid, a copolymer of D,L-lactic acid and mandelic acid, a copolymer of D,L-lactic acid and caprolactone, and a copolymer of D,L-lactic acid and 1,4-dioxan-2-one; in the formula 6, R is \u2014PAD-O\u2014C(O)\u2014CH 2 CH 2 \u2014C(O)\u2014OM, PAD is selected from the group consisting of D,L-polylactic acid, D-polylactic acid, polymandelic acid, a copolymer of D,L-lactic acid and glycolic acid, a copolymer of D,L-lactic acid and mandelic acid, a copolymer of D,L-lactic acid and caprolactone, and a copolymer of D,L-lactic acid and 1,4-dioxan-2-one; M is Na, K, or Li; and a is an integer of 1 to 4;\n YO\u2014[\u2014C(O)\u2014(CHX) a \u2014O\u2014] m \u2014C(O)\u2014R\u2014C(O)\u2014[\u2014O\u2014(CHX\u2032) b \u2014C(O)\u2014] n \u2014OZ \u2003\u2003[Chemical Formula 7] \n in the formula 7, X and X\u2032 are independently hydrogen, alkyl having 1 to 10 carbon atoms, or aryl having 6 to 20 carbon atoms; Y and Z are independently Na, K, or Li; m and n are independently integers of 0 to 95, with a proviso that 5<m+n<100; a and b are independently integers of 1 to 6; R is \u2014(CH 2 ) k \u2014, a divalent alkenyl having 2 to 10 carbon atoms, a divalent aryl having 6 to 20 carbon atoms, or a combination thereof, wherein k is an integer of 0 to 10.

Metadata:
- Claim Count in Document: 30.0
- Percentile: 94.0
- Lexical Diversity: 1.48077
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15137167', '14388043', '11974196', '10483826', '10104587']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7836844718882685
- 35 USC 102 Novelty (BERT): 0.5010191133657076
- Combined Prediction Score: 0.7554179360360124
- Mean Citation Score: 249.919342
- Max Citation Score: 284.58105
- Similarity Product: 235.2212151750684

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test