PATENT CLAIM ANALYSIS

Application Number: 16217948
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["514", "342000"]

Abstract:
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPV4 inhibitor. Further provided are compositions including a TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application. Further provided is a transgenic mouse whose genome includes deletions of the Trpv4 gene in keratinocytes of the epidermis, wherein said transgenic mouse is a knockout for the Trpv4 gene in keratinocytes of the epidermis following keratinocyte-specific activation and expression of a site-specific recombination enzyme.

Claim (Index 14):
The method of  claim 11 , wherein the TRPV4 inhibitor comprises a compound according to Formula I: wherein A, B, and C are independently selected from the group consisting of aromatic, heteroaromatic, cycloalkenyl, and heterocycloalkenyl groups; D is C 1 -C 3  alkylene; E is a bond, or C 1 -C 2  alkylene; and R is selected from the group consisting of hydrogen, hydroxyl, amino, alkyl, alkenyl, heteroalkyl, aromatic ring, or heteroaromatic ring.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 98.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15018595', '14413172', '15505898', '14497020', '14007823']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8271066265578978
- 35 USC 102 Novelty (BERT): 0.6128477115032095
- Combined Prediction Score: 0.805680735052429
- Mean Citation Score: 509.261558
- Max Citation Score: 775.4958
- Similarity Product: 475.3519584435225

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test