PATENT CLAIM ANALYSIS

Application Number: 16173236
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["435", "007100"]

Abstract:
A method for (a) diagnosing or monitoring kidney function in subject or (b) diagnosing kidney dysfunction in a subject or (c) predicting or monitoring the risk of an adverse events in a diseased subject or (d) predicting or monitoring the success of a therapy or intervention comprising determining the level of Pro-Enkephalin (PENK) or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said subject; and correlating said level of Pro-Enkephalin or fragments thereof with          (a) kidney function in a subject or (b) kidney dysfunction in said subject or (c) enhanced risk of adverse events or (d) success of a therapy or intervention in a diseased subject.

Claim (Index 20):
A method for diagnosing or monitoring kidney function in a subject comprising:\n determining the level of Pro-Enkephalin or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said subject; and wherein during follow-up measurement, a relative change of Pro-Enkephalin and fragments thereof that is lowered correlates with the improvement of the subject's kidney function, or wherein during follow-up measurement, a relative change of Pro-Enkephalin and fragment thereof that is increased correlates with the worsening of the subject's kidney function, and wherein said determination of Pro-Enkephalin or fragments thereof of at least 5 amino acids is performed more than once in one patient, and wherein said Pro-Enkephalin or fragment thereof is selected from the group comprising SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 5, SEQ ID No. 6, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10 and SEQ ID No. 11.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 97.0
- Lexical Diversity: 2.58824
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14432957', '15590571', '14432808', '14778114', '14759724']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5930200326662888
- 35 USC 102 Novelty (BERT): 0.5732128473495934
- Combined Prediction Score: 0.5910393141346193
- Mean Citation Score: 351.9070900000001
- Max Citation Score: 496.81204
- Similarity Product: 361.7466738319231

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test