PATENT CLAIM ANALYSIS

Application Number: 15972996
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "064000"]

Abstract:
Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.

Claim (Index 27):
A method for the treatment or prevention of a disease or condition associated with expression or activity of arginase I, arginase II, or a combination thereof in a subject, comprising administering to the subject a therapeutically effective amount of at least one compound according to Formula II: wherein R 6  is \u2014OH; R 7  is H; X is (C 3 -C 14 )-cycloalkylene; Y is \u2014NR\u2032R\u2033; M is selected from a bond, \u2014(C 1 -C 6 )alkylene-, \u2014O\u2014, \u2014C(O)\u2014, \u2014C(S)\u2014, \u2014C(O)NH\u2014, \u2014C(S)NH\u2014, \u2014S, \u2014S(O)\u2014, \u2014S(O) 2 \u2014, and \u2014NR\u2032\u2014; R 8  and R 9  are each hydrogen, D is butylene; R\u2032 and R\u2033 are independently selected from H, (C 1 -C 8 )alkyl, \u2014C(O)\u2014(C 1 -C 8 )alkylene, optionally substituted (C 3 -C 6 )aryl, optionally substituted (C 3 -C 14 )aryl(C 1 -C 6 )alkylene-, optionally substituted (C 1 -C 6 )aminoalkyl, optionally substituted (C 3 -C 6 )cycloalkyl, optionally substituted (C 3 -C 14 )heterocycloalkyl, optionally substituted (C 3 -C 14 )heteroaryl; and wherein any alkyl, alkylene, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl is optionally substituted with one or more members selected from halogen, oxo, \u2014COOH, \u2014CN, \u2014NO 2 , \u2014OH, \u2014NR d R e , \u2014NR g S(O) 2 R h , (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )haloalkoxy, (C 1 -C 6 )alkoxy, (C 3 -C 14 )aryl, (C 3 -C 14 )heteroaryl, (C 3 -C 14 )heterocycloalkyl, (C 3 -C 14 )heteroaryl-(C 1 -C 6 )alkylene and (C 3 -C 14 )aryloxy; wherein R d , R e , R g , and R h  are each independently selected from H, straight or branched (C 1 -C 6 )alkyl, optionally substituted (C 3 -C 14 )aryl(C 1 -C 6 )alkylene-, optionally substituted (C 3 -C 14 )aryl, (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 )aminoalkyl, H 2 N(C 1 -C 6 )alkylene-, optionally substituted (C 3 -C 6 )cycloalkyl, optionally substituted (C 3 -C 14 )heterocycloalkyl, optionally substituted (C 3 -C 14 )heteroaryl, optionally substituted (C 3 -C 14 )aryl-(C 1 -C 6 )alkylene-, and NR\u2032R\u2033C(O)\u2014, or a pharmaceutically acceptable salt, stereoisomer, tautomer, or prodrug thereof.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 93.0
- Lexical Diversity: 1.56897
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14471244', '15207902', '13276806', '14614115', '15540888']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8017914204681442
- 35 USC 102 Novelty (BERT): 0.5491831576031364
- Combined Prediction Score: 0.7765305941816434
- Mean Citation Score: 379.857086
- Max Citation Score: 434.2485
- Similarity Product: 297.755292329818

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test