PATENT CLAIM ANALYSIS

Application Number: 15770469
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["424", "190100"]

Abstract:
Provided are a method, target and application for NO accumulation to decrease invasiveness of  Pseudomonas aeruginosa  ( P. aeruginosa ); achieving NO accumulation by means of external NO donors or disruption of internal NO metabolism in an environment where  P. aeruginosa  is growing or being cultured, in order to decrease production by  P. aeruginosa  of the invasion factor pyocyanin. Utilizing even micro-quantities of NO can significantly inhibit  P. aeruginosa  PCN (PCN synthesis down 82% with 60 μM SNP treatment); by inhibiting NO reductase, an enzyme related to NO metabolism, PCN synthesis can be significantly inhibited (the PAO1 Δnor strain has 84% PCN reduction). Using NO donors or inhibiting enzymes involved in  P. aeruginosa  NO metabolism as a means of combating bacterial infectious disease does not affect the body's normal microflora like traditional antibiotics.

Claim (Index 7):
The method of reducing an invasiveness of  Pseudomonas aeruginosa  according to  claim 1 , wherein said method is used to provide an application of NO donor compound in the preparation of a medicament for reducing the invasiveness of  Pseudomonas aeruginosa.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 91.0
- Lexical Diversity: 1.63736
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['09653730', '15023279', '13013693', '11730186', '11915580']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6903561519954241
- 35 USC 102 Novelty (BERT): 0.5079982547306123
- Combined Prediction Score: 0.672120362268943
- Mean Citation Score: 204.67741000000004
- Max Citation Score: 218.53682
- Similarity Product: 142.7116028235245

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test