PATENT CLAIM ANALYSIS

Application Number: 16283640
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "343000"]

Abstract:
The invention provides novel compounds having the general formula (I) wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , X, A and R 11  are as described herein, compositions including the compounds and methods of using the compounds.

Claim (Index 1):
A compound of formula (I) or pharmaceutically acceptable salts thereof, wherein R 2 , R 3 , R 4 , R 5  and R 7  are independently selected from\n i) H, \n ii) C 1-6 -alkyl, and \n iii) C 3-8 -cycloalkyl; \n X is selected from\n i) \u2014O\u2014, \n ii) \u2014S\u2014, and \n iii) \u2014S(O) 2 \u2014; \n R 6  is selected from\n i) aryl substituted with R 12 , R 13  and R 14 , \n ii) aryl-C 1-6 -alkyl substituted with R 12 , R 13  and R 14 , \n iii) heteroaryl substituted with R 12 , R 13  and R 14 , and \n iv) heteroaryl-C 1-6 -alkyl substituted with R 12 , R 13  and R 14 ; \n A is selected from\n i) \u2014O\u2014, \n ii) \u2014CH 2 \u2014, \n iii) \u2014S(O) 2 NR 10 \u2014, and \n iv) \u2014C(O)NR 10 \u2014; \n R 8  is selected from\n i) H, and \n ii) \u2014CH 2 R 9 ; \n R 9  is selected from\n i) H, \n ii) hydroxy, \n iii) amino-C 1-6 -alkyl substituted on the nitrogen atom by one or two substituents selected from H, C 1-6 -alkylcarbonyl, C 1-6 -alkoxycarbonyl, C 1-6 -alkyl, arylcarbonyl and heteroarylcarbonyl, wherein arylcarbonyl and heteroarylcarbonyl are substituted with R 15 , R 16  and R 17 , \n iv) aminocarbonyl substituted on the nitrogen atom by one or two substituents selected from H, C 1-6 -alkylcarbonyl, C 1-6 -alkoxycarbonyl, C 1-6 -alkyl, arylcarbonyl and heteroarylcarbonyl, wherein arylcarbonyl and heteroarylcarbonyl are substituted with R 15 , R 16  and R 17 , \n v) aminocarbonyl-C 1-6 -alkyl substituted on the nitrogen atom by one or two substituents selected from H, C 1-6 -alkylcarbonyl, C 1-6 -alkoxycarbonyl, C 1-6 -alkyl, arylcarbonyl and heteroarylcarbonyl, wherein arylcarbonyl and heteroarylcarbonyl are substituted with R 15 , R 16  and R 17 , \n vi) carboxy, \n vii) carboxy-C 1-6 -alkyl, \n viii) C 1-6 -alkoxy, \n ix) C 1-6 -haloalkoxy, \n x) C 1-6 -alkoxycarbonyl, \n xi) C 1-6 -alkoxycarbonyl-C 1-6 -alkyl, \n xii) C 3-8 -cycloalkyl, \n xiii) aryl substituted with R 15 , R 16  and R 17 , \n xiv) aryl-C 1-6 -alkyl substituted with R 15 , R 16  and R 17 , \n xv) aryl-C 1-6 -alkoxy substituted with R 15 , R 16  and R 17 , \n xvi) heteroaryl substituted with R 15 , R 16  and R 17 , \n xvii) heteroaryl-C 1-6 -alkyl substituted with R 15 , R 16  and R 17 , and \n xviii) heteroaryl-C 1-6 -alkoxy substituted with R 15 , R 16  and R 17  \n xix) heterocycloalkyl substituted with R 15 , R 16  and R 17 , \n xx) heterocycloalkyl-C 1-6 -alkyl substituted with R 5 , R 16  and R 17 , \n xxi) heterocycloalkyl-C 1-6 -alkoxy substituted with R 15 , R 16  and R 17 , and \n xxii) C 1-6 -alkylsilyloxy; \n R 1  is selected from\n i) amino-C 1-6 -alkyl substituted on the nitrogen atom by R 21  and R 22 , \n ii) C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n iii) C 3-8 -cycloalkyl-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n iv) C 3-8 -cycloalkyl(halo)-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n v) aryl substituted with R 18 , R 19  and R 20 , \n vi) aryl-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n vii) aryl-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n viii) aryl-heterocycloalkyl substituted with R 18 , R 19  and R 20  \n ix) aryl(halo)-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n x) aryl(halo)-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n xi) aryl(halo)-heterocycloalkyl substituted with R 18 , R 19  and R 20 , \n xii) aryloxy-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n xiii) aryloxy-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n xiv) aryloxy-heterocycloalkyl substituted with R 18 , R 19  and R 20 , \n xv) aryloxy(halo)-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n xvi) aryloxy(halo)-heterocycloalkyl substituted with R 18 , R 19  and R 20  \n xvii) aryloxy(halo)-C 1-6 -alkyl, \n xviii) heterocycloalkyl substituted with R 18 , R 19  and R 20 , \n xix) heterocycloalkyl-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n xx) heterocycloalkyl-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n xxi) heterocycloalkyl(halo)-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n xxii) heterocycloalkyl(halo)-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n xxiii) heteroaryl substituted with R 18 , R 19  and R 20 , \n xxiv) heteroaryl-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n xxv) heteroaryl-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n xxvi) heteroaryl(halo)-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n xxvii) heteroaryl(halo)-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n xxviii) heteroaryloxy-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 , \n xxix) heteroaryloxy-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , \n xxx) heteroaryloxy(halo)-C 3-8 -cycloalkyl substituted with R 18 , R 19  and R 20 , and \n xxxi) heteroaryloxy(halo)-C 1-6 -alkyl substituted with R 18 , R 19  and R 20 ; \n R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19  and R 20  are independently selected from\n i) H, \n ii) cyano, \n iii) halogen, \n iv) oxo, \n v) C 1-6 -alkyl, \n vi) amino substituted on the nitrogen atom by two substituents independently selected from H, C 1-6 -alkyl, C 1-6 -alkoxycarbonyl, arylcarbonyl and heteroaryl carbonyl, \n vii) amino-C 1-6 -alkyl substituted on the nitrogen atom by two substituents independently selected from H, C 1-6 -alkyl, C 1-6 -alkoxycarbonyl, arylcarbonyl and heteroarylcarbonyl, \n viii) C 1-6 -alkyl, \n ix) halo-C 1-6 -alkyl, \n x) C 3-8 -cycloalkyl, \n xi) C 1-6 -alkoxycarbonyl-C 1-6 -alkyl, \n xii) carboxy-C 1-6 -alkyl, \n xiii) C 1-6 -alkoxycarbonyl-C 1-6 alkylaminocarbonyl-C 1-6 alkyl, \n xiv) carboxy-C 1-6 -alkylaminocarbonyl-C 1-6 alkyl, \n xv) C 1-6 -alkoxy, \n xvi) halo-C 1-6 -alkoxy, \n xvii) C 1-6 -alkoxycarbonyl-C 1-6 -alkoxy, \n xviii) carboxy-C 1-6 -alkoxy, \n xix) C 1-6 -alkoxycarbonyl-C 1-6 -alkylaminocarbonyl-C 1-6 -alkoxy, \n xx) carboxy-C 1-6 -alkylaminocarbonyl-C 1-6 -alkoxy, and \n xxi) heterocycloalkyl; \n and R 21  and R 22  are independently selected from\n i) H, \n ii) C 1-6 -alkoxycarbonyl, \n iii) carboxy-C 1-6 -alkyl, \n iv) arylcarbonyl, and \n v) heteroarylcarbonyl; \n with the proviso that N-[(1S)-1-[[(1S)-1-[(2S,4R)-4-benzyloxy-2-[(1-ethyl-3,3,3-trifluoro-2-oxo-propyl)carbamoyl]pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]pyrazine-2-carboxamide is excluded.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 99.0
- Lexical Diversity: 1.55556
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15683341', '11703522', '12829526', '12338432', '15031493']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8004767435686614
- 35 USC 102 Novelty (BERT): 0.5570576938020789
- Combined Prediction Score: 0.7761348385920032
- Mean Citation Score: 373.851888
- Max Citation Score: 427.60535
- Similarity Product: 303.73484634177083

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test