PATENT CLAIM ANALYSIS

Application Number: 15949902
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-12
Patent Classification: ["514", "04400A"]

Abstract:
Provided herein are methods and compositions for increasing production of a target protein or functional RNA by a cell.

Claim (Index 72):
A method of treating a human subject having a recessive disorder to increase the expression of a target protein or a target functional RNA by cells of the human subject, the method comprising contacting the cells of the human subject with an antisense oligomer (ASO), wherein the cells have a retained-intron-containing pre-mRNA (RIC pre-mRNA), wherein the RIC pre-mRNA comprises a retained intron, an exon flanking a 5\u2032 splice site of the retained intron, and an exon flanking a 3\u2032 splice site of the retained intron, and wherein the RIC pre-mRNA encodes the target protein or the target functional RNA; and\n whereby splicing of the retained intron from the RIC pre-mRNA encoding the target protein or the target functional RNA is modulated, and accumulation of the RIC pre-mRNA in nuclei of the cells or degradation of the RIC pre-mRNA in the cells is reduced compared to equivalent cells not contacted with the antisense oligomer, thereby increasing a level of mRNA encoding the target protein or the target functional RNA and increasing expression of the target protein or the target functional RNA by the cells of the human subject having the recessive disorder.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 91.0
- Lexical Diversity: 1.05263
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14874420', '14647952', '14897698', '13093958', '14134057']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7080533362869129
- 35 USC 102 Novelty (BERT): 0.76007072667
- Combined Prediction Score: 0.7132550753252217
- Mean Citation Score: 450.711916
- Max Citation Score: 893.8491
- Similarity Product: 872.3885799366832

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test