PATENT CLAIM ANALYSIS

Application Number: 15744448
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "234500"]

Abstract:
The present invention provides indazole and aza indazole compounds of formula (I) or (II) and pharmaceutically acceptable salts thereof, and their use to inhibit IRAK-4 and/or for the treatment of diseases or disorders induced by IRAK-4.

Claim (Index 2):
A compound of formula (II) or a pharmaceutically acceptable salt or stereoisomer thereof; wherein\n A is optionally substituted heteroaryl, optionally substituted aryl, optionally substituted heterocycloalkyl, optionally substituted cycloalkyl, optionally substituted (cycloalkyl)alkyl, optionally substituted (heterocycloalkyl)alkyl, optionally substituted aralkyl, optionally substituted heteroaralkyl, optionally substituted cycloalkyl-NR x \u2014, optionally substituted heterocycloalkyl-NR x \u2014, optionally substituted aryl-NR x \u2014, optionally substituted heteroaryl-NR x \u2014, optionally substituted cycloalkyl-O\u2014, optionally substituted heterocycloalkyl-O\u2014, optionally substituted aryl-O\u2014 or optionally substituted heteroaryl-O\u2014; e.g., wherein each optional substituent independently represents an occurrence of R z ; \n B is hydrogen, halogen, cyano, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxy, \u2014NR a R b , optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocycloalkyl, optionally substituted heteroaryl, optionally substituted (cycloalkyl)alkyl, optionally substituted (heterocycloalkyl)alkyl, optionally substituted aralkyl, optionally substituted heteroaralkyl, optionally substituted cycloalkyl-NR x \u2014, optionally substituted heterocycloalkyl-NR x \u2014, optionally substituted aryl-NR x \u2014, optionally substituted heteroaryl-NR x \u2014, optionally substituted cycloalkyl-O\u2014, optionally substituted heterocycloalkyl-O\u2014, optionally substituted aryl-O\u2014, optionally substituted heteroaryl-O\u2014; e.g., wherein each optional substituent independently represents an occurrence of R y ; \n Q is absent or optionally substituted heterocycloalkyl, optionally substituted heteroaryl, optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted (heterocycloalkyl)alkyl, optionally substituted (heteroaryl)alkyl, optionally substituted aralkyl, optionally substituted (cycloalkyl)alkyl, \u2014NR 3 R 4 , \u2014O\u2014R 3  or \u2014S\u2014R; e.g., wherein each optional substituent independently represents an occurrence of R z ; \n W is N or CH; \n R 1  is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted (cycloalkyl)alkyl, optionally substituted (heterocycloalkyl)alkyl, optionally substituted heterocycloalkyl, optionally substituted aralkyl, optionally substituted (heteroaryl)alkyl-, optionally substituted alkoxyalkyl, optionally substituted aminoalkyl, or \u2014(CH 2 ) m \u2014R 2 ; e.g., wherein each optional substituent independently represents one or more substituents selected from halo, hydroxy, alkoxy, amino, nitro, cycloalkyl, aryl, heterocycloalkyl and heteroaryl; \n R 2  is hydrogen, \u2014NR a R b , alkoxy, hydroxy, optionally substituted heteroaryl or optionally substituted heterocycloalkyl; e.g., wherein each optional substituent independently represents an occurrence of R y ; \n each R 3  and R 4  is independently selected from optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted aralkyl, optionally substituted (cycloalkyl)alkyl, optionally substituted (heteroaryl)alkyl and optionally substituted (heterocycloalkyl)alkyl; e.g., wherein each optional substituent independently represents one or more substituents selected from alkyl, halo, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, amino, nitro, cycloalkyl, (cycloalkyl)alkyl, aryl, aralkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heteroaryl and (heteroaryl)alkyl; \n each R a  and R b  is independently selected from hydrogen, alkyl, aminoalkyl, acyl and heterocyclyl; or R a  and R b  are taken together with the nitrogen to which they are attached to form an optionally substituted ring; \n R x  is hydrogen, alkyl, hydroxy, hydroxyalkyl, acyl or cycloalkyl; \n each R y  and R z , is independently selected from hydroxy, hydroxyalkyl, halo, alkyl, oxo, haloalkyl, alkoxy, alkenyloxy, amino, nitro, cyano, \u2014SH, \u2014S(alkyl), glycinate, ester, thioester, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, (cycloalkyl)alkyl, (heterocycloalkyl)alkyl, aralkyl, and (heteroaryl)alkyl; optionally wherein the hydroxy, hydroxyalkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl and heteroaryl are further substituted by one or more substituents selected from alkyl, halo, alkenyl, amino, nitro, cycloalkyl and (cycloalkyl)alkyl; or \n R Y  and R z  taken together with the atoms to which they are attached form an alkyl chain having 1-10 carbon atoms; optionally wherein 1-3 carbon atoms are replaced by O, NH or S; \n m is 1, 2, or 3; and \n n is 1 or 2.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 86.0
- Lexical Diversity: 1.23529
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15110309', '15667173', '15111000', '15106073', '13696601']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8095685063584925
- 35 USC 102 Novelty (BERT): 0.5845191893731683
- Combined Prediction Score: 0.7870635746599601
- Mean Citation Score: 436.33996800000006
- Max Citation Score: 504.22797
- Similarity Product: 422.71356688252513

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test