PATENT CLAIM ANALYSIS

Application Number: 15744207
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "314000"]

Abstract:
The present invention relates to the use of amitriptyline as an inhibitor of connexin hemichannels (HC) in the Central Nervous System (CNS). This HC-blocking agent is advantageously used to treat disorders involving misregulated HC (notably neuropathic pain, neurodegenerative disorders, ischemic brain injury and inflammatory intestinal conditions). Additionally, the invention provides a method to enhance the therapeutic effect of amitriptyline for its common indications. The method of the invention involves combining amitriptyline with another HC-blocking agent, mefloquine.

Claim (Index 4):
The therapeutic composition according to  claim 1 , for use for preventing and/or treating post herpetic neuropathic pain, diabetic neuropathic pain, post chirurgical neuropathic pain, post chemotherapy neuropathic pain, post-stroke neuropathic pain, post cancer treatment neuropathic pain or post chemoprophylaxis neuropathic pain, post-HIV neuropathic pain, chronic back neuropathic pain, low back neuropathic pain, traumatic neuropathy, neuropathic pain related to multiple sclerosis disease or to other immune diseases, or neuropathic pain induced by spinal cord injury.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 86.0
- Lexical Diversity: 1.47541
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14907221', '11295730', '13420111', '15834428', '14833041']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7007672549966173
- 35 USC 102 Novelty (BERT): 0.5454605374394241
- Combined Prediction Score: 0.685236583240898
- Mean Citation Score: 288.85656
- Max Citation Score: 393.6475
- Similarity Product: 304.8417955091596

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test