PATENT CLAIM ANALYSIS

Application Number: 15745431
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "04400A"]

Abstract:
Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication, by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting of SNAI2, SOX7 and other factors, the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment, the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention, a method of identifying at least one factor that modulates replication of a virus is also disclosed.

Claim (Index 59):
A method of identifying at least one factor that modulates replication of a virus, comprising:\n a) transfecting at least two cell lines of different origins with an expression construct comprising a selection marker operably linked to a viral promoter of the virus; b) detecting the expression of the selection marker to classify the at least two cell lines into permissive and non-permissive cell lines; c) transfecting the permissive and non-permissive cell lines with an expression construct comprising a viral replicon of the virus; d) screening for expression of at least one factor in said permissive and non-permissive cell lines of c), and comparing the expression of the at least one factor in the permissive cell line to the non-permissive cell line, to identify at least one candidate factor, wherein the differential expression of the at least one factor between the permissive and non-permissive cell line is indicative of identifying at least one candidate factor; e) contacting said permissive cell line expressing the viral replicon with an agent to knock out expression of said at least one candidate factor; and f) comparing the pre-genomic RNA level of said viral replicon in said permissive cell line of e), relative to a control cell line that has not been contacted with said agent, wherein a decrease or increase in the expression level of the pre-genomic RNA level in the permissive cell line, relative to the control cell line, indicates the identification of at least one factor that modulates replication of the virus.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 86.0
- Lexical Diversity: 1.80952
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15023284', '15268119', '15309680', '14380583', '13037931']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7148081437637909
- 35 USC 102 Novelty (BERT): 0.5060959405993878
- Combined Prediction Score: 0.6939369234473506
- Mean Citation Score: 205.083358
- Max Citation Score: 234.54459
- Similarity Product: 148.67796627127646

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test