PATENT CLAIM ANALYSIS

Application Number: 15896688
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "04400A"]

Abstract:
The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of antisense oligonucleotides (ASOs). Hybrid ASOs, part single-stranded and part double-stranded, are provided, hybridising to form a double-stranded region that can non-covalently bond to nucleic-acid-binding protein regions. In this way, ASO::protein complexes may be produced that facilitate delivery of antisense DNA into target cells. Such complexes may be used to down-regulate gene expression in cells.

Claim (Index 5):
The method according to  claim 1  wherein the shuttle protein is an attenuated toxin protein or a protein homologous thereto in which said attenuated toxin protein or homologous protein at least one toxin domain has been replaced by a said nucleic acid binding domain.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 88.0
- Lexical Diversity: 1.46667
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14899631', '12869232', '10473190', '10773911', '14783943']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7519714069228712
- 35 USC 102 Novelty (BERT): 0.6015609206171791
- Combined Prediction Score: 0.736930358292302
- Mean Citation Score: 282.845354
- Max Citation Score: 556.35284
- Similarity Product: 448.09620183434487

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test