PATENT CLAIM ANALYSIS

Application Number: 15956385
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["424", "499000"]

Abstract:
The disclosure provides a sustained release injectable neurosteroid formulation comprising neurosteroid particles having a D50 of less than 10 microns, the neurosteroid particles comprising a neurosteroid of Formula I: or a pharmaceutically acceptable salt thereof, wherein:   is a double or single bond and the variables, e.g., R 1 , R 2 , R 3 , R 4 , R 4a , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , and R 10a  are described herein. The formulation comprises neurosteroid particles comprising the neurosteroid and a polymeric surface stabilizer and provides an effective plasma concentration of the neurosteroid at steady state for at least 48 hours, and in some embodiments for at least 4 weeks. The sustained release injectable neurosteroid formulation can formulated for intramuscular or subcutaneous administration. The disclosure provides a method of treating a patient having seizures, anxiety, agitation, depression (including post-partum depression), schizophrenia, post-traumatic stress disorder, or tremors by administering the sustained release neurosteroid formulation to the patient. In certain embodiments the neurosteroid is ganaxolone.

Claim (Index 16):
A method of treating a patient having anxiety, agitation, depression, schizophrenia, post-traumatic stress disorder, or tremors, comprising administering the formulation of  claim 13  to the patient.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 91.0
- Lexical Diversity: 2.0102
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15700314', '14772726', '11587906', '12041038', '12320539']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6939516922281662
- 35 USC 102 Novelty (BERT): 0.5184875251384111
- Combined Prediction Score: 0.6764052755191907
- Mean Citation Score: 207.997362
- Max Citation Score: 269.98532
- Similarity Product: 150.40397742518903

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test