PATENT CLAIM ANALYSIS

Application Number: 15769113
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "243000"]

Abstract:
PRODRUGS OF IMIDAZOTRIAZINE COMPOUNDS AS CK2 INHIBITORS The invention provides pharmaceutically active compounds of formula (I) and prodrugs thereof. The formula (I) 2-(aminophenylamino)-4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazine derivatives inhibit CK2 protein kinase activity, thereby making them useful for treating cancer, psoriasis and rheumatoid arthritis.

Claim (Index 1):
A compound having Formula (I) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein\n R 1  is H, halogen, CN, \u2014NHC(O)C 1-4 alkyl, \u2014NHC(O)OC 1-4 alkyl, \u2014CHF 2  or \u2014OCHF 2 ; \n R 2  is H, \u2014C(\u2550O)O(CR c R c ) r OC(\u2550O)R d , \u2014C(\u2550O)N(CR c R c ) r OC(\u2550O)R d , or \u2014C(\u2550O)S(CR c R c ) r OC(\u2550O)R d ; \n R 3  is C 1-3 alkyl or C 3-6  cycloalkyl; \n R 4  and R 4  together with the nitrogen atom to which they are both attached form a 4- to 6-membered heterocycle containing carbon atoms and 0-3 additional heteroatoms selected from NR 5  O, and S, wherein the heterocycle is substituted with 1-3 R 6 ; \n R 5  is \u2014CHR c OR b , \u2014CHR c S(O) p R c , \u2014CHR c NR a R a , \u2014CHR c C(\u2550O)NR a R a , \u2014CHR c C(\u2550O)NR a S(O) p R c , \u2014CHR c NHC(\u2550O)OR b , \u2014CHR c OC(\u2550O)R d , \u2014CHR c S(O) 2 NR a R a , \u2014CHR c NR a S(O) p NR a R a , or \u2014CHR c NR a S(O) p R c ; \n R 6  is H, halogen, \u2014OR b , \u2014NR a R a , \u2014NR a C(\u2550O)R b , \u2014NHC(\u2550O)OR b , or \u2014(CR c R c ) r C(\u2550O)NR a R a , or, \u2014OC(\u2550O)(CH 2 ) r NH 2 , and \u2014NHS(O) 2 (C 1-4 alkyl); \n R a , is H or C 1-6  alkyl; \n R b  is H or C 1-6  alkyl; \n R c  is H or C 1-6  alkyl; \n R d  is straight or branched, saturated or unsaturated alkyl, allyl, cycloalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each optionally substituted; \n r is zero, 1, 2 or 3; \n provided when R 2  is H, then R 4  and R 4  together with the nitrogen atom to which they are both attached form \n and R 5  is \u2014CH(CH 3 )C(\u2550O)NR a R a .

Metadata:
- Claim Count in Document: 9.0
- Percentile: 91.0
- Lexical Diversity: 1.28261
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13940619', '14532218', '14414152', '14191861', '12575589']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8265781703452463
- 35 USC 102 Novelty (BERT): 0.549180702568597
- Combined Prediction Score: 0.7988384235675814
- Mean Citation Score: 394.033546
- Max Citation Score: 415.17645
- Similarity Product: 323.41044599120016

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test