PATENT CLAIM ANALYSIS

Application Number: 16079387
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "001000"]

Abstract:
Conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to an HSP90 targeting moiety via a linker have been designed. Nanoparticles and microparticles comprising such conjugates can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or other diseases.

Claim (Index 4):
The particle of  claim 1 , wherein the conjugate comprises Formula Ia: wherein X is the HSP90 targeting moiety; Z is the active agent; X\u2032 is either absent or independently selected from carbonyl, amide, urea, amino, ester, aryl, arylcarbonyl, aryloxy, arylamino, one or more natural or unnatural amino acids, thio or succinimido; R 1  and R 2  are either absent or comprised of alkyl, substituted alkyl, aryl, substituted aryl, polyethylene glycol (2-30 units); Y\u2032 is absent, substituted or unsubstituted 1,2-diaminoethane, polyethylene glycol (2-30 units) or an amide; Z\u2032 is either absent or independently selected from carbonyl, amide, urea, amino, ester, aryl, arylcarbonyl, aryloxy, arylamino, thio or succinimido.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 96.0
- Lexical Diversity: 1.61818
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12993853', '15652947', '14816228', '12993855', '14046827']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6772315663352563
- 35 USC 102 Novelty (BERT): 0.5179612764236425
- Combined Prediction Score: 0.661304537344095
- Mean Citation Score: 239.763438
- Max Citation Score: 245.89569
- Similarity Product: 147.6839997716779

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test