PATENT CLAIM ANALYSIS

Application Number: 15918195
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "210210"]

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

Claim (Index 2):
The compound of  claim 1 , or a stereoisomer, tautomer, pharmaceutically acceptable salt thereof, wherein:\n ring A is C 3-6  carbocycle; ring B is 4- to 7-membered heterocycle containing carbon atoms and 0-3 additional heteroatoms selected from the group consisting of N, NR 6 , O, and S(O) p ; optionally, ring B forms a fused ring or spiro ring with a 4- to 7-membered heterocycle containing carbon atoms and 1-3 heteroatoms selected from the group consisting of NR 6 , O, and S(O) p ; ring B, including the fused ring or spiro ring is substituted with 1-3 R 5 ; L is selected from the group consisting of: a bond, \u2014CHR 10 CHR 10 \u2014, \u2014CR 10 \u2550CR 10 \u2014, and \u2014C\u2261C\u2014; R 1 , at each occurrence, is selected from the group consisting of: H, halo, C 1-2  alkyl, \u2014O(C 1-4  alkyl), CN, \u2014CH 2 NH 2 , and \u2014C(\u2550NH)NH 2 ; R 2  is independently selected from the group consisting of: H, halo, CN, OH C 1-6  alkyl, C 1-4  alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy, CO(C 1-4  alkyl), and a 5- to 7-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NH, N(C 1-4  alkyl), O, and S(O) p , wherein said heterocycle is substituted with 1-2 R 2a ; R 2a , at each occurrence, is selected from the group consisting of: H, halo, C 1-4  alkyl, CO 2 H, \u2014CO 2 (C 1-4  alkyl), \u2014CONH 2 , \u2014CH 2 OH, \u2014CH 2 OC 1-4 alkyl, and \u2014CH 2 NH 2 ; R 3  is selected from the group consisting of: C 1-6  alkyl substituted with 1-3 R 3a , C 3-10  carbocycle substituted with 1-3 R 3a , and 5-10 membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of N, NR 7 , O, and S(O) p ; wherein said heterocycle is substituted with 1-3 R 3a ; R 3a , at each occurrence, is selected from the group consisting of: H, halo, C 1-4  alkyl, \u2014OH, C 1-4  alkoxy, \u2014CN, \u2014NH 2 , \u2014NH(C 1-4  alkyl), \u2014N(C 1-4  alkyl) 2 , \u2014CO 2 H, \u2014CH 2 CO 2 H, \u2014CO 2 (C 1-4  alkyl), \u2014CO 2 \u2014C 1-4  alkylene-O(C 1-4  alkyl), \u2014CO 2 \u2014C 1-4  alkylene-N(C 1-4  alkyl) 2 , \u2014CONH 2 , \u2014CONH(C 1-6  alkyl), \u2014CON(C 1-4  alkyl) 2 , \u2014CONH\u2014C 1-4  alkylene-CO 2 (C 1-4  alkyl), \u2014CONHCO 2 C 1-4  alkyl, \u2014CONH\u2014C 1-4  alkylene-NHCO(C 1-4  alkyl), \u2014CONH\u2014C 1-4  alkylene-CONH 2 , \u2014NHCOC 1-4  alkyl, \u2014NHCO 2 (C 1-4  alkyl), R f , \u2014CONHR f , and \u2014CO 2 R f ; R 4 , at each occurrence, is selected from the group consisting of: H, halo, and C 1-4  alkyl; R 5 , at each occurrence, is selected from the group consisting of: H, \u2550O, halo, C 1-4  alkyl, OH, CN, NH 2 , \u2014N(C 1-4  alkyl) 2 , NO 2 , C 1-4  alkoxy, \u2014OCO(C 1-4  alkyl), \u2014O\u2014C 1-4  alkylene-O(C 1-4  alkyl), \u2014O\u2014C 1-4  alkylene-N(C 1-4  alkyl) 2 , \u2014CO 2 H, \u2014CO 2 (C 1-4  alkyl), \u2014CONH 2 , \u2014(CH 2 ) 2 CONH 2 , \u2014CONR 9 (C 1-4  alkyl), \u2014CONR 9 \u2014C 1-4  alkylene-O(C 1-4  alkyl), \u2014CON(C 1-4  alkyl) 2 , \u2014CONR 9 \u2014C 1-4  alkylene-N(C 1-4  alkyl) 2 , \u2014CON(C 1-4  alkyl)-C 1-4  alkylene-O(C 1-4  alkyl), \u2014CONR 9 \u2014C 1-4  alkylene-CO 2 (C 1-4  alkyl), \u2014NR 9 COC 1-4  alkyl, \u2014NR 9 CO 2 C 1-4  alkyl, \u2014NR 9 CONH(C 1-4  alkyl), \u2014NR 9 CONR 9 \u2014C 1-4  alkylene-CO 2 C 1-4  alkyl, \u2014NR 9 \u2014C 1-4  alkylene-N(C 1-4  alkyl) 2 , R 8 , \u2014OR 8 , \u2014O\u2014C 1-4  alkylene-R 8 , \u2014COR 8 , \u2014CO 2 R 8 , \u2014CONR 9 R 8 , \u2014NR 9 COR 8 , \u2014NR 9 CO 2 R 8 , and \u2014NR 9 CON R 9 R 8 ; R 6  is selected from the group consisting of: H, C 1-4  alkyl, \u2014CO 2 (C 1-4  alkyl), \u2014CO(C 1-4  alkyl), \u2014CONH 2 , \u2014CO\u2014C 1-4  alkylene-N(C 1-4  alkyl) 2 , \u2014(CH 2 ) 2 N(C 1-4  alkyl) 2 , \u2014CONR 9 (C 1-4  alkyl), \u2014CONR 9 \u2014C 1-4  alkylene-O(C 1-4  alkyl), \u2014CONR 9 \u2014C 1-4  alkylene-N(C 1-4  alkyl) 2 , \u2014CONR 9 \u2014C 1-4  alkylene-CO 2 (C 1-4  alkyl), \u2014CON(C 1-4  alkyl) 2 , R 8 , \u2014COR 8 , \u2014CO 2 R 8 , and \u2014CONR 9 R 8 ; R 7 , at each occurrence, is selected from the group consisting of: H, C 1-4  alkyl, \u2014CO 2 (C 1-4  alkyl), and \u2014CO 2 \u2014C 1-4  alkylene-aryl; R 8 , at each occurrence, is selected from the group consisting of: \u2014(CH 2 ) n \u2014C 3-10  carbocycle and \u2014(CH 2 ) n -5-10 membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of N, NH, N(C 1-4  alkyl), O, and S(O) p ; wherein said carbocycle and heterocycle are optionally substituted with \u2550O; R 9 , at each occurrence, is selected from the group consisting of: H and C 1-4 alkyl; R 10 , at each occurrence, is selected from the group consisting of: H and F; R f , at each occurrence, is selected from the group consisting of: \u2014(CH 2 ) n \u2014C 3-6  cycloalkyl, \u2014(CH 2 ) n -phenyl, and \u2014(CH 2 ) n -5- to 6-membered heterocycle; wherein each ring moiety is substituted with 0-2 R g ; R g  is, independently at each occurrence, selected from the group consisting of: \u2550O, halo, C 1-4  alkyl, OH, C 1-4  alkoxy, and NHCO(C 1-4  alkyl); n, at each occurrence, is selected from 0, 1, 2, 3, and 4; and p, at each occurrence, is selected from 0, 1, and 2.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 90.0
- Lexical Diversity: 1.17949
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14117513', '15361589', '14617979', '14886415', '14350411']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8286910225265794
- 35 USC 102 Novelty (BERT): 0.6575702550622387
- Combined Prediction Score: 0.8115789457801453
- Mean Citation Score: 542.883702
- Max Citation Score: 635.02765
- Similarity Product: 628.5582258751631

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test