PATENT CLAIM ANALYSIS

Application Number: 15885944
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["424", "078170"]

Abstract:
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

Claim (Index 1):
A method of delivering a therapeutic agent to a human patient, to treat a functional disorder in a human patient's body, the method comprising administering to the human patient a plurality of nanoparticles having a targeting ligand and a therapeutic agent effective for treating the functional abnormality, wherein\n each nanoparticle comprises a polymer containing a polyol and a polymer containing a phenylboronic acid, wherein the polymer containing the phenylboronic acid is conjugated to the polymer containing the polyol with a reversible borate ester linkage; wherein the nanoparticle is configured to present the polymer containing a phenylboronic acid to an environment external to the nanoparticle; wherein the polymer containing a polyol comprises one or more of at least one of the following structural units of Formula (I), (II), or wherein A is independently derived from and wherein B is derived from: in which\n q is 1-20; \n p is 20-200; and \n L is a leaving group; and \n wherein the polymer containing a phenylboronic acid comprises at least one terminal phenylboronic acid group and has the general formula: wherein\n R 3  and R 4  are independently (CH 2 CH 2 O) t , where t is from 2 to 2000, \n X 1  is \u2014NH\u2014C(\u2550O)\u2014, \u2014S\u2014S\u2014, \u2014C(\u2550O)\u2014NH\u2014, \u2014O\u2014C(\u2550O)\u2014 or \u2014C(\u2550O)\u2014O\u2014, \n Y 1  is a phenyl group, \n wherein r=1, a=0 and b=1, and \n wherein Functional group 1 and Functional group 2 are the same or different and independently comprise \u2014B(OH) 2 , \u2014OCH 3 , \u2014(X 1 )\u2014(Y 1 )\u2014B(OH) 2 , \u2014COOH, \u2014NH 2 , or \u2014OH.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 88.0
- Lexical Diversity: 1.6
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15371640', '15137453', '14805831', '15291485', '13782458']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7680316769390858
- 35 USC 102 Novelty (BERT): 0.5909726859239205
- Combined Prediction Score: 0.7503257778375693
- Mean Citation Score: 491.39875599999993
- Max Citation Score: 512.1393400000002
- Similarity Product: 435.7731647700192

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test