PATENT CLAIM ANALYSIS

Application Number: 16066555
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "233200"]

Abstract:
The invention provides compounds for activating the activating transcription factor 6 (ATF6) arm of the unfolded protein response (UPR), or activating the transcriptional targets of ATF6, in the endoplasmic reticulum of a cell, the compounds being of any of formulas (I) through (IX) as described herein. The compounds can be used for treatment of conditions involving gain-of-toxic-function and loss-of-function folding disorders including lysosomal storage diseases, antitrypsin-associated emphysema and similar diseases. These molecules are also expected to have disease-ameliorating effects in Alzheimer's disease and diabetes.

Claim (Index 6):
The method of  claim 1  wherein the protein misfolding disease is associated with secretory pathway protein homeostasis stresses, including diabetes, metabolic disorders, eye disease, and cardiovascular disease.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 94.0
- Lexical Diversity: 1.44928
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14849428', '15614278', '12992128', '12280793', '11217137']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.761278463714864
- 35 USC 102 Novelty (BERT): 0.5385765628743631
- Combined Prediction Score: 0.7390082736308139
- Mean Citation Score: 301.845864
- Max Citation Score: 336.1769700000001
- Similarity Product: 177.5562222942639

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test