PATENT CLAIM ANALYSIS

Application Number: 15991703
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "303000"]

Abstract:
The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

Claim (Index 1):
A compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein,\n ring vertex A 0  is NH or C(O); \n each of ring vertices A 1  and A 3  are independently selected from the group consisting of N, NH, CH, C(O) and C(R 4 ); \n each of ring vertices A 2 , A 5  and A 6  is independently selected from the group consisting of N, CH, and C(R 4 ); \n ring vertex A 4  is selected from the group consisting of N, N(C 1-4  alkyl), CH, and C(R 4 ); \n and no more than two of A 3 , A 4 , A 5  and A 6  are N; \n each of the dashed bonds independently is a single or double bond; \n R 1  is selected from the group consisting of heteroaryl, C 6-10  aryl, \u2014C 1-8  alkylene-heteroaryl, \u2014C 1-8 alkylene-C 6-10  aryl, C 3-8  cycloalkyl, four to eight membered heterocycloalkyl, C 1-8  alkyl, C 1-8  haloalkyl, \u2014C(O)NR 1a R 1b , and \u2014CO 2 R 1a ; wherein the heterocycloalkyl group is a 4 to 8 membered ring having from 1 to 3 heteroatoms as ring vertices selected from N, O and S; the heteroaryl group is a 5 to 10 membered aromatic ring having from 1 to 3 heteroatoms as ring vertices selected from N, O and S; \n wherein R 1a  and R 1b  are each independently selected from the group consisting of hydrogen, C 1-8  alkyl, C 6-10  aryl, and \u2014C 1-6  alkylene-C 6-10  aryl; \n wherein R 1  is optionally substituted with 1 to 5 R 5  substituents; \n R 2a  and R 2e  are each independently selected from the group consisting of C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, \u2014O\u2014C 1-6  haloalkyl, \u2014S\u2014C 1-6  alkyl, \u2014C 1-6  alkyl-O\u2014C 1-6  alkyl, \u2014C 1-6  alkyl-S\u2014C 1-6  alkyl, CN, and halogen; \n R 2b , R 2c , and R 2d  are each independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, \u2014O\u2014C 1-6  haloalkyl, \u2014S\u2014C 1-6  alkyl, \u2014C 1-6  alkyl-O\u2014C 1-6  alkyl, \u2014C 1-6  alkyl-S\u2014C 1-6  alkyl, cyano, and halogen; \n each R 3  is independently selected from the group consisting of C 1-4  alkyl, C 1-4  haloalkyl and hydroxyl, and optionally two R 3  groups on the same carbon atom are combined to form oxo (\u2550O); \n each R 4  is independently selected from the group consisting of C 1-6  alkyl, C 1-6  alkoxy, C 1-6  hydroxyalkyl, C 1-6  haloalkyl, C 1-6  haloalkoxy, \u2014O\u2014C 1-6  haloalkyl, halogen, cyano, hydroxyl, \u2014S\u2014C 1-6  alkyl, \u2014C 1-6  alkyl-O\u2014C 1-6  alkyl, \u2014C 1-6  alkyl-S\u2014C 1-6  alkyl, \u2014NR 4a R 4b , \u2014CONR 4a R 4b , \u2014CO 2 R 4a , \u2014COR 4a , \u2014OC(O)NR 4a R 4b , \u2014NR 4a C(O)R 4b , \u2014NR 4a C(O) 2 R 4b , and \u2014NR 4a \u2014C(O)NR 4a R 4b ; \n each R 4a  and R 4b  is independently selected from the group consisting of hydrogen, C 1-4  alkyl, and C 1-4  haloalkyl; \n each R 5  is independently selected from the group consisting of C 1-8  alkyl, C 1-8  alkoxy, C 1-8  haloalkyl, C 1-8  haloalkoxy, C 1-8  hydroxyalkyl, \u2014C 1-8  alkyl-heterocycloalkyl, \u2014C 1-8  alkyl-C 3-8  cycloalkyl, C 3-6  cycloalkyl, heterocycloalkyl, halogen, OH, C 2-8  alkenyl, C 2-8  alkynyl, CN, C(O)R 5a , \u2014NR 5b C(O)R 5a , \u2014CONR 5a R 5b , \u2014NR 5a R 5b , \u2014C 1-8  alkylene-NR 5a R 5b , \u2014S\u2014C 1-6  alkyl, \u2014C 1-6  alkyl-O\u2014C 1-6  alkyl, \u2014C 1-6  alkyl-S\u2014C1.6 alkyl, \u2014OC(O)NR 5a R 5b , \u2014NR 5a C(O) 2 R 5b , \u2014NR 5a \u2014C(O)NR 5b R 5b  and CO 2 R 5a ; wherein wherein the heterocycloalkyl group is a 4 to 8 membered ring having from 1 to 3 heteroatoms as ring vertices selected from N, O and S; \n wherein each R 5a  and R 5b  is independently selected from the group consisting of hydrogen, C 1-4  alkyl, and C 1-4  haloalkyl, or when attached to the same nitrogen atom R 5a  and R 5b  are combined with the nitrogen atom to form a five or six-membered ring having from 0 to 1 additional heteroatoms as ring vertices selected from N, O, or S; and \n the subscript n is 0, 1, 2 or 3.

Metadata:
- Claim Count in Document: 75.0
- Percentile: 93.0
- Lexical Diversity: 1.2381
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15991747', '13947995', '14503198', '12765034', '14887171']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7940224286824024
- 35 USC 102 Novelty (BERT): 0.5767461196919387
- Combined Prediction Score: 0.772294797783356
- Mean Citation Score: 367.032208
- Max Citation Score: 475.89847
- Similarity Product: 385.92869230948327

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test