PATENT CLAIM ANALYSIS

Application Number: 16058437
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["424", "049000"]

Abstract:
Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I): wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably trans); or —CR a ═CR b — a stilbene derivative; where R a  and R b  are independently H or phenyl optionally substituted with —(R 3 ) p  or —(R 4 ) q ; R 1  to R 4  are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R 1  to R 2  is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.

Claim (Index 10):
The method of  claim 1 , wherein the wound or skin condition is one or more selected from aging, autoimmune diseases with inflammation, avascular necrosis, bacterial infection, cancers, diabetic neuropathies, endometriosis, fungal infection, gout, hairloss, infectious arthritis, inflammation, inflammatory bowel, ischemia, Lyme disease, organ/tissue transplant, parasitic infection, psoriatic arthritis, psoriasis, pseudogout, rheumatoid arthritis, scleraderma, scurvy, sepsis, skin diseases, surgical scars, surgical adhesions, transfection procedures, ulcerative colitis, ulcers, viral infection, warts, surgical wounds, incisions, lacerations, cuts and scrapes, donor site wounds from skin transplants, traumatic wounds, infectious wounds, ischemic wounds, burns, bullous wounds, aseptic wounds, contused wounds, incised wounds, lacerated wounds, non-penetrating wounds, open wounds, penetrating wounds, perforating wounds, puncture wounds, septic wounds, subcutaneous wounds, chronic ulcers, gastric ulcers, skin ulcers, peptic ulcer, duodenal ulcer, gastric ulcer, gouty ulcer, hypertensive ischemic ulcer, stasis ulcer, sublingual ulcer, submucous ulcer, symptomatic ulcer, trophic ulcer, tropical ulcer, veneral ulcer, hyperkeratosis, photo-aging, psoriasis, skin rashes, sunburns, photoreactive processes, mouth sores and burns, post-extraction wounds, endodontic wounds, ulcers and lesions of bacterial or viral or autoimmunological origin, mechanical wounds, chemical wounds, thermal wounds, infectious and lichenoid wounds, herpes ulcers, stomatitis, aphthosa, acute necrotizing ulcerative gingivitis, burning mouth syndrome, corneal ulcers, radial keratotomy, corneal transplants, epikeratophakia, surgically induced wounds in the eye, hemorrhoids, pruritus, proctitis, anal fissures, dry cracked skin, seborrheic conditions, anthrax, tetanus, gas gangrene, scalatina, erysipelas, sycosis barbae, folliculitis, impetigo contagiosa, and impetigo bullosa.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 96.0
- Lexical Diversity: 2.10619
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15093146', '11665807', '15106283', '13990301', '15106284']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7248604093743563
- 35 USC 102 Novelty (BERT): 0.6299800121584835
- Combined Prediction Score: 0.715372369652769
- Mean Citation Score: 258.67112000000003
- Max Citation Score: 616.81635
- Similarity Product: 525.0124864653737

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test