PATENT CLAIM ANALYSIS

Application Number: 15743769
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "029000"]

Abstract:
The present invention relates to dye compounds represented by Formulae I and II, which are described in the specification. The dye compounds of the present invention have markedly improved quantum yields and emit strong fluorescence compared to existing cyanine dyes. Due to these advantages, the dye compounds of the present invention can find applications in various fields, for example, as probes for various biological systems where optical imaging is required. Particularly, the dye compounds of the present invention can be used as mitotrackers capable of labeling and tracking mitochondria. Therefore, the dye compounds of the present invention can be used to quantitatively image mitochondria in live tissues and cells. Furthermore, the dye compounds of the present invention can be applied as pH probes for measuring the pH of live cells.

Claim (Index 1):
A dye compound represented by Formula I or II: wherein Ar 1  is C 6 -C 20  aryl or C 2 -C 20  heteroaryl which is optionally substituted with one or more substituents selected from hydrogen, deuterium, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryloxy, substituted or unsubstituted aryloxyalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkoxyalkyl, halogen, cyano, nitro, amine, hydroxyl, aldehyde, amino, amide, hydrazine, thiol, acetal, ketal, phosphoryl, phosphate, phosphonate, sulfohydroxyl, sulfonyl, sulfonate, sulfate, carboxylate, azido, guanidium, carbonyl, thiocarbonyl, aminothiocarbonyl, carboxyl, carboxylic acid, ketone, sulfhydryl, acyl chloride, sulfonic acid, ester, polyalkylene oxide, polyethylene glycol, and quaternary ammonium, the alkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, aryloxy, aryloxyalkyl, alkoxy, and alkoxyalkyl being optionally further substituted with one or more substituents selected from halogen, cyano, nitro, amine, hydroxyl, aldehyde, amino, amide, hydrazine, thiol, acetal, ketal, phosphoryl, phosphate, phosphonate, sulfohydroxyl, sulfonyl, sulfonate, sulfate, carboxylate, azido, guanidium, carbonyl, thiocarbonyl, am inothiocarbonyl, carboxyl, carboxylic acid, ketone, sulfhydryl, acyl chloride, sulfonic acid, ester, polyalkylene oxide, polyethylene glycol, and quaternary ammonium, each E is CR 1  or N, Z 1  is NR 2 R 3 , OR 4  or SR 5 , X is O, S, NR 8 R 9 , SiR 10 R 11 , CR 12 R 13  or Se, Y is CR 14 R 15 , NR 16 , O, S, Se, SiR 17 R 18  or CR 19 R 20 \u2550CR 21 R 22 , W is CR 23 R 24 , CR 25 R 26 \u2550CR5 27 R 28 , O, \u2014[CR 29 R 30 \u2014CR 31 R 32 ]\u2014 or \u2014[CR 33 R 34 \u2014O]\u2014, R 23  to R 34  are identical to or different from each other and are each independently hydrogen, deuterium, alkyl or acryloxy, and two adjacent substituents are optionally linked to each other to form an alicyclic hydrocarbon, two of R 1  to R 3  optionally form an alicyclic hydrocarbon ring or a monocyclic or polycyclic aromatic hydrocarbon ring with two of the adjacent substituents, and carbon atom of the alicyclic or aromatic hydrocarbon ring is optionally replaced by a substituent selected from N, S, O, Se, Te, Po, NR 35 , SiR 36 R 37 , GeR 38 R 39 , PR 40 , and BR 41 , R 1  to R 22  and R 35  to R 41  are identical to or different from each other and are each independently selected from hydrogen, deuterium, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryloxy, substituted or unsubstituted aryloxyalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkoxyalkyl, halogen, cyano, nitro, amine, hydroxyl, aldehyde, amino, amide, hydrazine, thiol, acetal, ketal, phosphoryl, phosphate, phosphonate, sulfohydroxyl, sulfonyl, sulfonate, sulfate, carboxylate, azido, guanidium, carbonyl, thiocarbonyl, aminothiocarbonyl, carboxyl, carboxylic acid, ketone, sulfhydryl, acyl chloride, sulfonic acid, ester, polyalkylene oxide, polyethylene glycol, and quaternary ammonium, the alkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, aryloxy, aryloxyalkyl, alkoxy, and alkoxyalkyl being optionally further substituted with one or more substituents selected from halogen, cyano, nitro, amine, hydroxyl, aldehyde, amino, amide, hydrazine, thiol, acetal, ketal, phosphoryl, phosphate, phosphonate, sulfohydroxyl, sulfonyl, sulfonate, sulfate, carboxylate, azido, guanidium, carbonyl, thiocarbonyl, aminothiocarbonyl, carboxyl, carboxylic acid, ketone, sulfhydryl, acyl chloride, sulfonic acid, ester, polyalkylene oxide, polyethylene glycol, and quaternary ammonium, and A \u2212  is an anion or a cation represented by A +  as an organic or inorganic ion and is optionally absent; or wherein Ar 1 , E, X, Y, W, and R 1  are as defined in Formula I, Z 2  is NR 6 , O, S or O + R 7 , and R 6  and R 7  are as defined in Formula I.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 86.0
- Lexical Diversity: 2.01408
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14733764', '14061670', '10916822', '12583496', '12820077']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6953890864872841
- 35 USC 102 Novelty (BERT): 0.526709650192784
- Combined Prediction Score: 0.6785211428578342
- Mean Citation Score: 336.539302
- Max Citation Score: 355.66455
- Similarity Product: 253.3353232393474

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test