PATENT CLAIM ANALYSIS

Application Number: 16301826
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["514", "254060"]

Abstract:
The present invention relates to a new crystalline form of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide, process for its preparation, its utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing it.

Claim (Index 29):
A process for preparing the crystalline Form 4 of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide of the following formula (I) comprising the following steps: a) adding the acyl chloride of formula (ID: to the indazol-3-ylamine of formula (III): blocking the addition when the indazol-3-ylamine of formula (III) is completely reacted; b) deprotecting under mild basic conditions the resulting compound of formula (IV): to obtain the compound of formula (I) as defined above; c) suspending in ethanol the obtained compound of formula (I); d) heating the suspension of step c) to a temperature between about 50\u00b0 C. and about 70\u00b0 C. and cooling to room temperature; and e) adding water, filtering and drying to give the crystalline Form 4 of compound of formula (I); or, alternatively: f) heating at reflux temperature a slurry of crystalline Form 2 of compound of formula (I) in ethanol to obtain a solution and cooling the solution to a temperature between about 50\u00b0 C. and about 65\u00b0 C.; g) adding an amount of crystalline Form 4 seeds, obtained as defined in steps a) to e) to the solution of step f), followed by adding water; h) heating the mixture of step g) at reflux temperature for a time period ranging from 30 to 90 minutes, followed by cooling the mixture to room temperature and stirring for about 12 hours; i) filtering the mixture of step h) and drying at about 40\u00b0 C. to obtain the crystalline Form 4 of the compound of formula (I), as defined in  claim 19 .

Metadata:
- Claim Count in Document: 35.0
- Percentile: 98.0
- Lexical Diversity: 1.13636
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14623904', '16050516', '16051815', '14953969', '15172478']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7519023857682554
- 35 USC 102 Novelty (BERT): 0.5155229192045307
- Combined Prediction Score: 0.728264439111883
- Mean Citation Score: 293.132042
- Max Citation Score: 305.8803
- Similarity Product: 222.16983232827184

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test