PATENT CLAIM ANALYSIS

Application Number: 15904198
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["435", "135000"]

Abstract:
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.

Claim (Index 62):
A non-naturally occurring microbial organism comprising:\n (a) a methanol metabolic pathway, wherein said non-naturally occurring microbial organism comprises at least one exogenous nucleic acid encoding a methanol metabolic pathway enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of methanol or metabolize methanol as a carbon source for biosynthesis of fumarate, wherein said methanol metabolic pathway comprises:\n (i) a methanol methyltransferase and a methylenetetrahydrofolate reductase; \n (ii) a methanol dehydrogenase; or \n (iii) a methanol dehydrogenase and a formaldehyde activating enzyme; and \n (b) a fumarate pathway comprising exogenous nucleic acids wherein at least one of said exogenous nucleic acids is a heterologous nucleic acid encoding a fumarate pathway enzyme expressed in a sufficient amount to produce fumarate, said fumarate pathway comprising:\n (i) a phosphoenolpyruvate (PEP) carboxylase or a PEP carboxykinase, a malate dehydrogenase, and a fumarase; \n (ii) a pyruvate carboxylase, a malate dehydrogenase, and a fumarase; or \n (iii) a malic enzyme, and a fumarase.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 88.0
- Lexical Diversity: 1.41304
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14059285', '15133150', '14107832', '13975678', '14071318']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6113216246719535
- 35 USC 102 Novelty (BERT): 0.6846815936131476
- Combined Prediction Score: 0.618657621566073
- Mean Citation Score: 636.0017339999997
- Max Citation Score: 694.06165
- Similarity Product: 686.0342686579883

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test