PATENT CLAIM ANALYSIS

Application Number: 15895848
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "182000"]

Abstract:
Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

Claim (Index 2):
The method of  claim 1 , wherein\n R 1  through R 4 , R 6 , R 7 , R 11 , R 12 , R 15 , R 16 , and R 18  are independently selected from the group consisting of hydrogen, hydroxyl, substituted or unsubstituted (C 1 -C 18 ) alkyl, substituted or unsubstituted (C 1 -C 18 ) hydroxyalkyl, substituted or unsubstituted (C 1 -C 18 ) alkyloxy-(C 1 -C 18 ) alkyl, substituted or unsubstituted (C 1 -C 18 ) alkylcarboxy-(C 1 -C 18 ) alkyl, substituted or unsubstituted (C 1 -C 18 ) alkylamino-(C 1 -C 18 )alkyl, substituted or unsubstituted (C 1 -C 18 ) alkylamino-(C 1 -C 18 ) alkylamino, substituted or unsubstituted (C 1 -C 18 ) alkylamino-(C 1 -C 18 ) alkylamino-(C 1 -C 18 ) alkylamino, substituted or unsubstituted (C 1 -C 18 ) aminoalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylamino-(C 1 -C 18 ) alkyl, substituted or unsubstituted (C 1 -C 18 ) haloalkyl, substituted or unsubstituted C 2 -C 6  alkenyl, substituted or unsubstituted C 2 -C 6  alkynyl, oxo, linking group attached to a second CSA, substituted or unsubstituted (C 1 -C 18 ) aminoalkyloxy, substituted or unsubstituted (C 1 -C 18 ) aminoalkyloxy-(C 1 -C 18 ) alkyl, substituted or unsubstituted (C 1 -C 18 ) aminoalkylcarboxy, substituted or unsubstituted (C 1 -C 18 ) aminoalkylaminocarbonyl, substituted or unsubstituted (C 1 -C 18 ) aminoalkylcarboxamido, substituted or unsubstituted di(C 1 -C 18  alkyl)aminoalkyl, H 2 N\u2014HC(Q 5 )-C(O)\u2014O\u2014, H 2 N\u2014HC(Q 5 )-C(O)\u2014N(H)\u2014, substituted or unsubstituted (C 1 -C 18 ) azidoalkyloxy, substituted or unsubstituted (C 1 -C 18 ) cyanoalkyloxy, P.G.-HN\u2014HC(Q 5 )-C(O)\u2014O\u2014, substituted or unsubstituted (C 1 -C 18 ) guanidinoalkyloxy, substituted or unsubstituted (C 1 -C 18 ) quaternary ammonium alkylcarboxy, and substituted or unsubstituted (C 1 -C 18 ) guanidinoalkyl carboxy, where Q 5  is a side chain of an amino acid, and P.G. is an amino protecting group; R 5 , R 8 , R 9 , R 10 , R 13 , R 14  and R 17  are independently deleted when one of rings A, B, C, or D is unsaturated so as to complete the valency of the carbon atom at that site, or R 5 , R 8 , R 9 , R 10 , R 13 , and R 14  are independently selected from the group consisting of hydrogen, hydroxyl, substituted or unsubstituted (C 1 -C 18 ) alkyl, substituted or unsubstituted (C 1 -C 18 ) hydroxyalkyl, substituted or unsubstituted (C 1 -C 18 ) alkyloxy-(C 1 -C 18 ) alkyl, substituted or unsubstituted (C 1 -C 18 ) aminoalkyl, substituted or unsubstituted aryl, substituted or unsubstituted (C 1 -C 18 ) haloalkyl, substituted or unsubstituted (C 2 -C 6 ) alkenyl, substituted or unsubstituted (C 2 -C 6 ) alkynyl, oxo, a linking group attached to a second CSA, substituted or unsubstituted (C 1 -C 18 ) aminoalkyloxy, substituted or unsubstituted (C 1 -C 18 ) aminoalkylcarboxy, substituted or unsubstituted (C 1 -C 18 ) aminoalkylaminocarbonyl, substituted or unsubstituted di(C 1 -C 18  alkyl)aminoalkyl, H 2 N\u2014HC(Q 5 )-C(O)\u2014O\u2014, H 2 N\u2014HC(Q 5 )-C(O)\u2014N(H)\u2014, substituted or unsubstituted (C 1 -C 18 ) azidoalkyloxy, substituted or unsubstituted (C 1 -C 18 ) cyanoalkyloxy, P.G.-HN\u2014HC(Q 5 )-C(O)\u2014O\u2014, substituted or unsubstituted (C 1 -C 18 ) guanidinoalkyloxy, and (C 1 -C 18 ) guanidinoalkylcarboxy, where Q 5  is a side chain of an amino acid, and P.G. is an amino protecting group; provided that at least two of R 1-4 , R 6 , R 7 , R 11 , R 12 , R 15 , R 16 , R 17 , and R 18  are independently selected from the group consisting of substituted or unsubstituted (C 1 -C 18 ) aminoalkyl, substituted or unsubstituted (C 1 -C 18 ) aminoalkyloxy, substituted or unsubstituted (C 1 -C 18 ) alkylcarboxy-(C 1 -C 18 ) alkyl, substituted or unsubstituted (C 1 -C 18 ) alkylamino-(C 1 -C 18 ) alkylamino, substituted or unsubstituted (C 1 -C 18 ) alkylamino-(C 1 -C 18 ) alkylamino (C 1 -C 18 ) alkylamino, substituted or unsubstituted (C 1 -C 18 ) aminoalkylcarboxy, substituted or unsubstituted arylamino (C 1 -C 18 ) alkyl, substituted or unsubstituted (C 1 -C 18 ) aminoalkyloxy (C 1 -C 18 ) aminoalkylaminocarbonyl, substituted or unsubstituted (C 1 -C 18 ) aminoalkylaminocarbonyl, substituted or unsubstituted (C 1 -C 18 ) aminoalkylcarboxyamido, a substituted or unsubstituted (C 1 -C 18 ) quaternary ammonium alkylcarboxy, substituted or unsubstituted di(C 1 -C 18  alkyl)aminoalkyl, H 2 N\u2014HC(Q 5 )-C(O)\u2014O\u2014, H 2 N\u2014HC(Q 5 )-C(O)\u2014N(H)\u2014, substituted or unsubstituted (C 1 -C 18 ) azidoalkyloxy, substituted or unsubstituted (C 1 -C 18 ) cyanoalkyloxy, P.G.-HN\u2014HC(Q 5 )-C(O)\u2014O\u2014, substituted or unsubstituted (C 1 -C 18 ) guanidinoalkyloxy, and substituted or unsubstituted (C 1 -C 18 ) guanidinoalkylcarboxy.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.32609
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14149675', '13615324', '14842582', '13615244', '14848819']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8824531002602238
- 35 USC 102 Novelty (BERT): 0.676087245702933
- Combined Prediction Score: 0.8618165148044948
- Mean Citation Score: 639.1508240000003
- Max Citation Score: 688.5246
- Similarity Product: 676.5111761901139

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test