PATENT CLAIM ANALYSIS

Application Number: 16246300
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-11
Patent Classification: ["435", "183000"]

Abstract:
Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.

Claim (Index 118):
The method of  claim 117 , wherein the titration dosage is adjusted to attain a blood phenylalanine concentration of below 600 \u03bcM.

Metadata:
- Claim Count in Document: 183.0
- Percentile: 99.0
- Lexical Diversity: 1.4918
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15130694', '12107731', '12107736', '11807227', '12421557']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7681678564309645
- 35 USC 102 Novelty (BERT): 0.5976866786833833
- Combined Prediction Score: 0.7511197386562064
- Mean Citation Score: 621.6747379999998
- Max Citation Score: 671.7732
- Similarity Product: 441.0911670729161

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test