PATENT CLAIM ANALYSIS

Application Number: 16100596
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["514", "322000"]

Abstract:
Disclosed are chemical entities of Formula (I): wherein R 1  and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).

Claim (Index 26):
A chemical entity selected from Table 1.C, Table 1.E1 and Table 1.E2: TABLE 1.C   (racemic) compound Z R 5 R 6 R 7 C-1.1\u2003 Z1 H H H C-1.2\u2003 Z1 CH 3 H H C-1.3\u2003 Z1 Cl H H C-1.4\u2003 Z1 F H H C-1.5\u2003 Z1 CH 2 CH 3 H H C-1.6\u2003 Z1 CF 2 H H H C-1.7\u2003 Z1 CH 2 F H H C-1.8\u2003 Z1 CF 3 H H C-1.9\u2003 Z1 CF 2 CH 3 H H C-1.10\u2002 Z1 CH 2 CF 3 H H C-1.11\u2002 Z1 cyclopropyl H H C-1.12\u2002 Z1 OCF 3 H H C-1.13\u2002 Z1 OCF 2 H H H C-1.14\u2002 Z1 Cl H F C-1.15\u2002 Z1 CH 3 H F C-1.16\u2002 Z1 CH 3 F H C-1.17\u2002 Z1 Cl F H C-1.18\u2002 Z1 F F H C-1.19\u2002 Z1 F H F C-1.20\u2002 Z1 F H Cl C-1.21\u2002 Z1 F H CH 3 C-1.22\u2002 Z1 Cl H CH 3 C-1.23\u2002 Z1 SCH 3 H H C-1.24\u2002 Z1 SO 2 CH 3 H H C-1.25\u2002 Z1 ethynyl H H C-2.1\u2003 Z2 H H H C-2.2\u2003 Z2 CH 3 H H C-2.3\u2003 Z2 Cl H H C-2.4\u2003 Z2 F H H C-2.5\u2003 Z2 CH 2 CH 3 H H C-2.6\u2003 Z2 CF 2 H H H C-2.7\u2003 Z2 CH 2 F H H C-2.8\u2003 Z2 CF 3 H H C-2.9\u2003 Z2 CF 2 CH 3 H H C-2.10\u2002 Z2 CH 2 CF 3 H H C-2.11\u2002 Z2 cyclopropyl H H C-2.12\u2002 Z2 OCF 3 H H C-2.13\u2002 Z2 OCF 2 H H H C-2.14\u2002 Z2 Cl H F C-2.15\u2002 Z2 CH 3 H F C-2.16\u2002 Z2 CH 3 F H C-2.17\u2002 Z2 Cl F H C-2.18\u2002 Z2 F F H C-2.19\u2002 Z2 F H F C-2.20\u2002 Z2 F H Cl C-2.21\u2002 Z2 F H CH 3 C-2.22\u2002 Z2 Cl H CH 3 C-2.23\u2002 Z2 SCH 3 H H C-2.24\u2002 Z2 SO 2 CH 3 H H C-2.25\u2002 Z2 ethynyl H H C-3.1\u2003 Z3 H H H C-3.2\u2003 Z3 CH 3 H H C-3.3\u2003 Z3 Cl H H C-3.4\u2003 Z3 F H H C-3.5\u2003 Z3 CH 2 CH 3 H H C-3.6\u2003 Z3 CF 2 H H H C-3.7\u2003 Z3 CH 2 F H H C-3.8\u2003 Z3 CF 3 H H C-3.9\u2003 Z3 CF 2 CH 3 H H C-3.10\u2002 Z3 CH 2 CF 3 H H C-3.11\u2002 Z3 cyclopropyl H H C-3.12\u2002 Z3 OCF 3 H H C-3.13\u2002 Z3 OCF 2 H H H C-3.14\u2002 Z3 Cl H F C-3.15\u2002 Z3 CH 3 H F C-3.16\u2002 Z3 CH 3 F H C-3.17\u2002 Z3 Cl F H C-3.18\u2002 Z3 F F H C-3.19\u2002 Z3 F H F C-3.20\u2002 Z3 F H Cl C-3.21\u2002 Z3 F H CH 3 C-3.22\u2002 Z3 Cl H CH 3 C-3.23\u2002 Z3 SCH 3 H H C-3.24\u2002 Z3 SO 2 CH 3 H H C-3.25\u2002 Z3 ethynyl H H C-4.1\u2003 Z4 H H H C-4.2\u2003 Z4 CH 3 H H C-4.3\u2003 Z4 Cl H H C-4.4\u2003 Z4 F H H C-4.5\u2003 Z4 CH 2 CH 3 H H C-4.6\u2003 Z4 CF 2 H H H C-4.7\u2003 Z4 CH 2 F H H C-4.8\u2003 Z4 CF 3 H H C-4.9\u2003 Z4 CF 2 CH 3 H H C-4.10\u2002 Z4 CH 2 CF 3 H H C-4.11\u2002 Z4 cyclopropyl H H C-4.12\u2002 Z4 OCF 3 H H C-4.13\u2002 Z4 OCF 2 H H H C-4.14\u2002 Z4 Cl H F C-4.15\u2002 Z4 CH 3 H F C-4.16\u2002 Z4 CH 3 F H C-4.17\u2002 Z4 Cl F H C-4.18\u2002 Z4 F F H C-4.19\u2002 Z4 F H F C-4.20\u2002 Z4 F H Cl C-4.21\u2002 Z4 F H CH 3 C-4.22\u2002 Z4 Cl H CH 3 C-4.23\u2002 Z4 SCH 3 H H C-4.24\u2002 Z4 SO 2 CH 3 H H C-4.25\u2002 Z4 ethynyl H H C-5.1\u2003 Z5 H H H C-5.2\u2003 Z5 CH 3 H H C-5.3\u2003 Z5 Cl H H C-5.4\u2003 Z5 F H H C-5.5\u2003 Z5 CH 2 CH 3 H H C-5.6\u2003 Z5 CF 2 H H H C-5.7\u2003 Z5 CH 2 F H H C-5.8\u2003 Z5 CF 3 H H C-5.9\u2003 Z5 CF 2 CH 3 H H C-5.10\u2002 Z5 CH 2 CF 3 H H C-5.11\u2002 Z5 cyclopropyl H H C-5.12\u2002 Z5 OCF 3 H H C-5.13\u2002 Z5 OCF 2 H H H C-5.14\u2002 Z5 Cl H F C-5.15\u2002 Z5 CH 3 H F C-5.16\u2002 Z5 CH 3 F H C-5.17\u2002 Z5 Cl F H C-5.18\u2002 Z5 F F H C-5.19\u2002 Z5 F H F C-5.20\u2002 Z5 F H Cl C-5.21\u2002 Z5 F H CH 3 C-5.22\u2002 Z5 Cl H CH 3 C-5.23\u2002 Z5 SCH 3 H H C-5.24\u2002 Z5 SO 2 CH 3 H H C-5.25\u2002 Z5 ethynyl H H C-6.1\u2003 Z6, R a  is H H H H C-6.2\u2003 Z6, R a  is H CH 3 H H C-6.3\u2003 Z6, R a  is H Cl H H C-6.4\u2003 Z6, R a  is H F H H C-6.5\u2003 Z6, R a  is H CH 2 CH 3 H H C-6.6\u2003 Z6, R a  is H CF 2 H H H C-6.7\u2003 Z6, R a  is H CH 2 F H H C-6.8\u2003 Z6, R a  is H CF 3 H H C-6.9\u2003 Z6, R a  is H CF 2 CH 3 H H C-6.10\u2002 Z6, R a  is H CH 2 CF 3 H H C-6.11\u2002 Z6, R a  is H cyclopropyl H H C-6.12\u2002 Z6, R a  is H OCF 3 H H C-6.13\u2002 Z6, R a  is H OCF 2 H H H C-6.14\u2002 Z6, R a  is H Cl H F C-6.15\u2002 Z6, R a  is H CH 3 H F C-6.16\u2002 Z6, R a  is H CH 3 F H C-6.17\u2002 Z6, R a  is H Cl F H C-6.18\u2002 Z6, R a  is H F F H C-6.19\u2002 Z6, R a  is H F H F C-6.20\u2002 Z6, R a  is H F H Cl C-6.21\u2002 Z6, R a  is H F H CH 3 C-6.22\u2002 Z6, R a  is H Cl H CH 3 C-6.23\u2002 Z6, R a  is H SCH 3 H H C-6.24\u2002 Z6, R a  is H SO 2 CH 3 H H C-6.25\u2002 Z6, R a  is H ethynyl H H C-7.1\u2003 Z7, R a  is H H H H C-7.2\u2003 Z7, R a  is H CH 3 H H C-7.3\u2003 Z7, R a  is H Cl H H C-7.4\u2003 Z7, R a  is H F H H C-7.5\u2003 Z7, R a  is H CH 2 CH 3 H H C-7.6\u2003 Z7, R a  is H CF 2 H H H C-7.7\u2003 Z7, R a  is H CH 2 F H H C-7.8\u2003 Z7, R a  is H CF 3 H H C-7.9\u2003 Z7, R a  is H CF 2 CH 3 H H C-7.10\u2002 Z7, R a  is H CH 2 CF 3 H H C-7.11\u2002 Z7, R a  is H cyclopropyl H H C-7.12\u2002 Z7, R a  is H OCF 3 H H C-7.13\u2002 Z7, R a  is H OCF 2 H H H C-7.14\u2002 Z7, R a  is H Cl H F C-7.15\u2002 Z7, R a  is H CH 3 H F C-7.16\u2002 Z7, R a  is H CH 3 F H C-7.17\u2002 Z7, R a  is H Cl F H C-7.18\u2002 Z7, R a  is H F F H C-7.19\u2002 Z7, R a  is H F H F C-7.20\u2002 Z7, R a  is H F H Cl C-7.21\u2002 Z7, R a  is H F H CH 3 C-7.22\u2002 Z7, R a  is H Cl H CH 3 C-7.23\u2002 Z7, R a  is H SCH 3 H H C-7.24\u2002 Z7, R a  is H SO 2 CH 3 H H C-7.25\u2002 Z7, R a  is H ethynyl H H C-8.1\u2003 Z8, R a  is H H H H C-8.2\u2003 Z8, R a  is H CH 3 H H C-8.3\u2003 Z8, R a  is H Cl H H C-8.4\u2003 Z8, R a  is H F H H C-8.5\u2003 Z8, R a  is H CH 2 CH 3 H H C-8.6\u2003 Z8, R a  is H CF 2 H H H C-8.7\u2003 Z8, R a  is H CH 2 F H H C-8.8\u2003 Z8, R a  is H CF 3 H H C-8.9\u2003 Z8, R a  is H CF 2 CH 3 H H C-8.10\u2002 Z8, R a  is H CH 2 CF 3 H H C-8.11\u2002 Z8, R a  is H cyclopropyl H H C-8.12\u2002 Z8, R a  is H OCF 3 H H C-8.13\u2002 Z8, R a  is H OCF 2 H H H C-8.14\u2002 Z8, R a  is H Cl H F C-8.15\u2002 Z8, R a  is H CH 3 H F C-8.16\u2002 Z8, R a  is H CH 3 F H C-8.17\u2002 Z8, R a  is H Cl F H C-8.18\u2002 Z8, R a  is H F F H C-8.19\u2002 Z8, R a  is H F H F C-8.20\u2002 Z8, R a  is H F H Cl C-8.21\u2002 Z8, R a  is H F H CH 3 C-8.22\u2002 Z8, R a  is H Cl H CH 3 C-8.23\u2002 Z8, R a  is H SCH 3 H H C-8.24\u2002 Z8, R a  is H SO 2 CH 3 H H C-8.25\u2002 Z8, R a  is H ethynyl H H C-9.1\u2003 Z9 H H H C-9.2\u2003 Z9 CH 3 H H C-9.3\u2003 Z9 Cl H H C-9.4\u2003 Z9 F H H C-9.5\u2003 Z9 CH 2 CH 3 H H C-9.6\u2003 Z9 CF 2 H H H C-9.7\u2003 Z9 CH 2 F H H C-9.8\u2003 Z9 CF 3 H H C-9.9\u2003 Z9 CF 2 CH 3 H H C-9.10\u2002 Z9 CH 2 CF 3 H H C-9.11\u2002 Z9 cyclopropyl H H C-9.12\u2002 Z9 OCF 3 H H C-9.13\u2002 Z9 OCF 2 H H H C-9.14\u2002 Z9 Cl H F C-9.15\u2002 Z9 CH 3 H F C-9.16\u2002 Z9 CH 3 F H C-9.17\u2002 Z9 Cl F H C-9.18\u2002 Z9 F F H C-9.19\u2002 Z9 F H F C-9.20\u2002 Z9 F H Cl C-9.21\u2002 Z9 F H CH 3 C-9.22\u2002 Z9 Cl H CH 3 C-9.23\u2002 Z9 SCH 3 H H C-9.24\u2002 Z9 SO 2 CH 3 H H C-9.25\u2002 Z9 ethynyl H H C-10.1\u2002 Z10 H H H C-10.2\u2002 Z10 CH 3 H H C-10.3\u2002 Z10 Cl H H C-10.4\u2002 Z10 F H H C-10.5\u2002 Z10 CH 2 CH 3 H H C-10.6\u2002 Z10 CF 2 H H H C-10.7\u2002 Z10 CH 2 F H H C-10.8\u2002 Z10 CF 3 H H C-10.9\u2002 Z10 CF 2 CH 3 H H C-10.10 Z10 CH 2 CF 3 H H C-10.11 Z10 cyclopropyl H H C-10.12 Z10 OCF 3 H H C-10.13 Z10 OCF 2 H H H C-10.14 Z10 Cl H F C-10.15 Z10 CH 3 H F C-10.16 Z10 CH 3 F H C-10.17 Z10 Cl F H C-10.18 Z10 F F H C-10.19 Z10 F H F C-10.20 Z10 F H Cl C-10.21 Z10 F H CH 3 C-10.22 Z10 Cl H CH 3 C-10.23 Z10 SCH 3 H H C-10.24 Z10 SO 2 CH 3 H H C-10.25 Z10 ethynyl H H C-11.1\u2002 Z11, R a  is H H H H C-11.2\u2002 Z11, R a  is H CH 3 H H C-11.3\u2002 Z11, R a  is H Cl H H C-11.4\u2002 Z11, R a  is H F H H C-11.5\u2002 Z11, R a  is H CH 2 CH 3 H H C-11.6\u2002 Z11, R a  is H CF 2 H H H C-11.7\u2002 Z11, R a  is H CH 2 F H H C-11.8\u2002 Z11, R a  is H CF 3 H H C-11.9\u2002 Z11, R a  is H CF 2 CH 3 H H C-11.10 Z11, R a  is H CH 2 CF 3 H H C-11.11 Z11, R a  is H cyclopropyl H H C-11.12 Z11, R a  is H OCF 3 H H C-11.13 Z11, R a  is H OCF 2 H H H C-11.14 Z11, R a  is H Cl H F C-11.15 Z11, R a  is H CH 3 H F C-11.16 Z11, R a  is H CH 3 F H C-11.17 Z11, R a  is H Cl F H C-11.18 Z11, R a  is H F F H C-11.19 Z11, R a  is H F H F C-11.20 Z11, R a  is H F H Cl C-11.21 Z11, R a  is H F H CH 3 C-11.22 Z11, R a  is H Cl H CH 3 C-11.23 Z11, R a  is H SCH 3 H H C-11.24 Z11, R a  is H SO 2 CH 3 H H C-11.25 Z11, R a  is H ethynyl H H C-12.1\u2002 Z12 H H H C-12.2\u2002 Z12 CH 3 H H C-12.3\u2002 Z12 Cl H H C-12.4\u2002 Z12 F H H C-12.5\u2002 Z12 CH 2 CH 3 H H C-12.6\u2002 Z12 CF 2 H H H C-12.7\u2002 Z12 CH 2 F H H C-12.8\u2002 Z12 CF 3 H H C-12.9\u2002 Z12 CF 2 CH 3 H H C-12.10 Z12 CH 2 CF 3 H H C-12.11 Z12 cyclopropyl H H C-12.12 Z12 OCF 3 H H C-12.13 Z12 OCF 2 H H H C-12.14 Z12 Cl H F C-12.15 Z12 CH 3 H F C-12.16 Z12 CH 3 F H C-12.17 Z12 Cl F H C-12.18 Z12 F F H C-12.19 Z12 F H F C-12.20 Z12 F H Cl C-12.21 Z12 F H CH 3 C-12.22 Z12 Cl H CH 3 C-12.23 Z12 SCH 3 H H C-12.24 Z12 SO 2 CH 3 H H C-12.25 Z12 ethynyl H H C-13.1\u2002 Z13, R a  is H H H H C-13.2\u2002 Z13, R a  is H CH 3 H H C-13.3\u2002 Z13, R a  is H Cl H H C-13.4\u2002 Z13, R a  is H F H H C-13.5\u2002 Z13, R a  is H CH 2 CH 3 H H C-13.6\u2002 Z13, R a  is H CF 2 H H H C-13.7\u2002 Z13, R a  is H CH 2 F H H C-13.8\u2002 Z13, R a  is H CF 3 H H C-13.9\u2002 Z13, R a  is H CF 2 CH 3 H H C-13.10 Z13, R a  is H CH 2 CF 3 H H C-13.11 Z13, R a  is H cyclopropyl H H C-13.12 Z13, R a  is H OCF 3 H H C-13.13 Z13, R a  is H OCF 2 H H H C-13.14 Z13, R a  is H Cl H F C-13.15 Z13, R a  is H CH 3 H F C-13.16 Z13, R a  is H CH 3 F H C-13.17 Z13, R a  is H Cl F H C-13.18 Z13, R a  is H F F H C-13.19 Z13, R a  is H F H F C-13.20 Z13, R a  is H F H Cl C-13.21 Z13, R a  is H F H CH 3 C-13.22 Z13, R a  is H Cl H CH 3 C-13.23 Z13, R a  is H SCH 3 H H C-13.24 Z13, R a  is H SO 2 CH 3 H H C-13.25 Z13, R a  is H ethynyl H H C-14.1\u2002 Z14, R a  is H H H H C-14.2\u2002 Z14, R a  is H CH 3 H H C-14.3\u2002 Z14, R a  is H Cl H H C-14.4\u2002 Z14, R a  is H F H H C-14.5\u2002 Z14, R a  is H CH 2 CH 3 H H C-14.6\u2002 Z14, R a  is H CF 2 H H H C-14.7\u2002 Z14, R a  is H CH 2 F H H C-14.8\u2002 Z14, R a  is H CF 3 H H C-14.9\u2002 Z14, R a  is H CF 2 CH 3 H H C-14.10 Z14, R a  is H CH 2 CF 3 H H C-14.11 Z14, R a  is H cyclopropyl H H C-14.12 Z14, R a  is H OCF 3 H H C-14.13 Z14, R a  is H OCF 2 H H H C-14.14 Z14, R a  is H Cl H F C-14.15 Z14, R a  is H CH 3 H F C-14.16 Z14, R a  is H CH 3 F H C-14.17 Z14, R a  is H Cl F H C-14.18 Z14, R a  is H F F H C-14.19 Z14, R a  is H F H F C-14.20 Z14, R a  is H F H Cl C-14.21 Z14, R a  is H F H CH 3 C-14.22 Z14, R a  is H Cl H CH 3 C-14.23 Z14, R a  is H SCH 3 H H C-14.24 Z14, R a  is H SO 2 CH 3 H H C-14.25 Z14, R a  is H ethynyl H H C-15.1\u2002 Z15, R a  is H H H H C-15.2\u2002 Z15, R a  is H CH 3 H H C-15.3\u2002 Z15, R a  is H Cl H H C-15.4\u2002 Z15, R a  is H F H H C-15.5\u2002 Z15, R a  is H CH 2 CH 3 H H C-15.6\u2002 Z15, R a  is H CF 2 H H H C-15.7\u2002 Z15, R a  is H CH 2 F H H C-15.8\u2002 Z15, R a  is H CF 3 H H C-15.9\u2002 Z15, R a  is H CF 2 CH 3 H H C-15.10 Z15, R a  is H CH 2 CF 3 H H C-15.11 Z15, R a  is H cyclopropyl H H C-15.12 Z15, R a  is H OCF 3 H H C-15.13 Z15, R a  is H OCF 2 H H H C-15.14 Z15, R a  is H Cl H F C-15.15 Z15, R a  is H CH 3 H F C-15.16 Z15, R a  is H CH 3 F H C-15.17 Z15, R a  is H Cl F H C-15.18 Z15, R a  is H F F H C-15.19 Z15, R a  is H F H F C-15.20 Z15, R a  is H F H Cl C-15.21 Z15, R a  is H F H CH 3 C-15.22 Z15, R a  is H Cl H CH 3 C-15.23 Z15, R a  is H SCH 3 H H C-15.24 Z15, R a  is H SO 2 CH 3 H H C-15.25 Z15, R a  is H ethynyl H H C-16.1\u2002 Z16, R a  is H H H H C-16.2\u2002 Z16, R a  is H CH 3 H H C-16.3\u2002 Z16, R a  is H Cl H H C-16.4\u2002 Z16, R a  is H F H H C-16.5\u2002 Z16, R a  is H CH 2 CH 3 H H C-16.6\u2002 Z16, R a  is H CF 2 H H H C-16.7\u2002 Z16, R a  is H CH 2 F H H C-16.8\u2002 Z16, R a  is H CF 3 H H C-16.9\u2002 Z16, R a  is H CF 2 CH 3 H H C-16.10 Z16, R a  is H CH 2 CF 3 H H C-16.11 Z16, R a  is H cyclopropyl H H C-16.12 Z16, R a  is H OCF 3 H H C-16.13 Z16, R a  is H OCF 2 H H H C-16.14 Z16, R a  is H Cl H F C-16.15 Z16, R a  is H CH 3 H F C-16.16 Z16, R a  is H CH 3 F H C-16.17 Z16, R a  is H Cl F H C-16.18 Z16, R a  is H F F H C-16.19 Z16, R a  is H F H F C-16.20 Z16, R a  is H F H Cl C-16.21 Z16, R a  is H F H CH 3 C-16.22 Z16, R a  is H Cl H CH 3 C-16.23 Z16, R a  is H SCH 3 H H C-16.24 Z16, R a  is H SO 2 CH 3 H H C-16.25 Z16, R a  is H ethynyl H H C-17.1\u2002 Z17 H H H C-17.2\u2002 Z17 CH 3 H H C-17.3\u2002 Z17 Cl H H C-17.4\u2002 Z17 F H H C-17.5\u2002 Z17 CH 2 CH 3 H H C-17.6\u2002 Z17 CF 2 H H H C-17.7\u2002 Z17 CH 2 F H H C-17.8\u2002 Z17 CF 3 H H C-17.9\u2002 Z17 CF 2 CH 3 H H C-17.10 Z17 CH 2 CF 3 H H C-17.11 Z17 cyclopropyl H H C-17.12 Z17 OCF 3 H H C-17.13 Z17 OCF 2 H H H C-17.14 Z17 Cl H F C-17.15 Z17 CH 3 H F C-17.16 Z17 CH 3 F H C-17.17 Z17 Cl F H C-17.18 Z17 F F H C-17.19 Z17 F H F C-17.20 Z17 F H Cl C-17.21 Z17 F H CH 3 C-17.22 Z17 Cl H CH 3 C-17.23 Z17 SCH 3 H H C-17.24 Z17 SO 2 CH 3 H H C-17.25 Z17 ethynyl H H C-18.1\u2002 Z18 H H H C-18.2\u2002 Z18 CH 3 H H C-18.3\u2002 Z18 Cl H H C-18.4\u2002 Z18 F H H C-18.5\u2002 Z18 CH 2 CH 3 H H C-18.6\u2002 Z18 CF 2 H H H C-18.7\u2002 Z18 CH 2 F H H C-18.8\u2002 Z18 CF 3 H H C-18.9\u2002 Z18 CF 2 CH 3 H H C-18.10 Z18 CH 2 CF 3 H H C-18.11 Z18 cyclopropyl H H C-18.12 Z18 OCF 3 H H C-18.13 Z18 OCF 2 H H H C-18.14 Z18 Cl H F C-18.15 Z18 CH 3 H F C-18.16 Z18 CH 3 F H C-18.17 Z18 Cl F H C-18.18 Z18 F F H C-18.19 Z18 F H F C-18.20 Z18 F H Cl C-18.21 Z18 F H CH 3 C-18.22 Z18 Cl H CH 3 C-18.23 Z18 SCH 3 H H C-18.24 Z18 SO 2 CH 3 H H C-18.25 Z18 ethynyl H H C-19.1\u2002 Z19 H H H C-19.2\u2002 Z19 CH 3 H H C-19.3\u2002 Z19 Cl H H C-19.4\u2002 Z19 F H H C-19.5\u2002 Z19 CH 2 CH 3 H H C-19.6\u2002 Z19 CF 2 H H H C-19.7\u2002 Z19 CH 2 F H H C-19.8\u2002 Z19 CF 3 H H C-19.9\u2002 Z19 CF 2 CH 3 H H C-19.10 Z19 CH 2 CF 3 H H C-19.11 Z19 cyclopropyl H H C-19.12 Z19 OCF 3 H H C-19.13 Z19 OCF 2 H H H C-19.14 Z19 Cl H F C-19.15 Z19 CH 3 H F C-19.16 Z19 CH 3 F H C-19.17 Z19 Cl F H C-19.18 Z19 F F H C-19.19 Z19 F H F C-19.20 Z19 F H Cl C-19.21 Z19 F H CH 3 C-19.22 Z19 Cl H CH 3 C-19.23 Z19 SCH 3 H H C-19.24 Z19 SO 2 CH 3 H H C-19.25 Z19 ethynyl H H C-19.26 Z19 CH 3 H H C-20.1\u2002 Z20 H H H C-20.2\u2002 Z20 CH 3 H H C-20.3\u2002 Z20 Cl H H C-20.4\u2002 Z20 F H H C-20.5\u2002 Z20 CH 2 CH 3 H H C-20.6\u2002 Z20 CF 2 H H H C-20.7\u2002 Z20 CH 2 F H H C-20.8\u2002 Z20 CF 3 H H C-20.9\u2002 Z20 CF 2 CH 3 H H C-20.10 Z20 CH 2 CF 3 H H C-20.11 Z20 cyclopropyl H H C-20.12 Z20 OCF 3 H H C-20.13 Z20 OCF 2 H H H C-20.14 Z20 Cl H F C-20.15 Z20 CH 3 H F C-20.16 Z20 CH 3 F H C-20.17 Z20 Cl F H C-20.18 Z20 F F H C-20.19 Z20 F H F C-20.20 Z20 F H Cl C-20.21 Z20 F H CH 3 C-20.22 Z20 Cl H CH 3 C-20.23 Z20 SCH 3 H H C-20.24 Z20 SO 2 CH 3 H H C-20.25 Z20 ethynyl H H C-21.1\u2002 Z21 H H H C-21.2\u2002 Z21 CH 3 H H C-21.3\u2002 Z21 Cl H H C-21.4\u2002 Z21 F H H C-21.5\u2002 Z21 CH 2 CH 3 H H C-21.6\u2002 Z21 CF 2 H H H C-21.7\u2002 Z21 CH 2 F H H C-21.8\u2002 Z21 CF 3 H H C-21.9\u2002 Z21 CF 2 CH 3 H H C-21.10 Z21 CH 2 CF 3 H H C-21.11 Z21 cyclopropyl H H C-21.12 Z21 OCF 3 H H C-21.13 Z21 OCF 2 H H H C-21.14 Z21 Cl H F C-21.15 Z21 CH 3 H F C-21.16 Z21 CH 3 F H C-21.17 Z21 Cl F H C-21.18 Z21 F F H C-21.19 Z21 F H F C-21.20 Z21 F H Cl C-21.21 Z21 F H CH 3 C-21.22 Z21 Cl H CH 3 C-21.23 Z21 SCH 3 H H C-21.24 Z21 SO 2 CH 3 H H C-21.25 Z21 ethynyl H H   C-21.26 CH 3 H H   C-22.1\u2002 Z22 H H H C-22.2\u2002 Z22 CH 3 H H C-22.3\u2002 Z22 Cl H H C-22.4\u2002 Z22 F H H C-22.5\u2002 Z22 CH 2 CH 3 H H C-22.6\u2002 Z22 CF 2 H H H C-22.7\u2002 Z22 CH 2 F H H C-22.8\u2002 Z22 CF 3 H H C-22.9\u2002 Z22 CF 2 CH 3 H H C-22.10 Z22 CH 2 CF 3 H H C-22.11 Z22 cyclopropyl H H C-22.12 Z22 OCF 3 H H C-22.13 Z22 OCF 2 H H H C-22.14 Z22 Cl H F C-22.15 Z22 CH 3 H F C-22.16 Z22 CH 3 F H C-22.17 Z22 Cl F H C-22.18 Z22 F F H C-22.19 Z22 F H F C-22.20 Z22 F H Cl C-22.21 Z22 F H CH 3 C-22.22 Z22 Cl H CH 3 C-22.23 Z22 SCH 3 H H C-22.24 Z22 SO 2 CH 3 H H C-22.25 Z22 ethynyl H H C-23.1\u2002 Z23 H H H C-23.2\u2002 Z23 CH 3 H H C-23.3\u2002 Z23 Cl H H C-23.4\u2002 Z23 F H H C-23.5\u2002 Z23 CH 2 CH 3 H H C-23.6\u2002 Z23 CF 2 H H H C-23.7\u2002 Z23 CH 2 F H H C-23.8\u2002 Z23 CF 3 H H C-23.9\u2002 Z23 CF 2 CH 3 H H C-23.10 Z23 CH 2 CF 3 H H C-23.11 Z23 cyclopropyl H H C-23.12 Z23 OCF 3 H H C-23.13 Z23 OCF 2 H H H C-23.14 Z23 Cl H F C-23.15 Z23 CH 3 H F C-23.16 Z23 CH 3 F H C-23.17 Z23 Cl F H C-23.18 Z23 F F H C-23.19 Z23 F H F C-23.20 Z23 F H Cl C-23.21 Z23 F H CH 3 C-23.22 Z23 Cl H CH 3 C-23.23 Z23 SCH 3 H H C-23.24 Z23 SO 2 CH 3 H H C-23.25 Z23 ethynyl H H C-24.1\u2002 Z24 H H H C-24.2\u2002 Z24 CH 3 H H C-24.3\u2002 Z24 Cl H H C-24.4\u2002 Z24 F H H C-24.5\u2002 Z24 CH 2 CH 3 H H C-24.6\u2002 Z24 CF 2 H H H C-24.7\u2002 Z24 CH 2 F H H C-24.8\u2002 Z24 CF 3 H H C-24.9\u2002 Z24 CF 2 CH 3 H H C-24.10 Z24 CH 2 CF 3 H H C-24.11 Z24 cyclopropyl H H C-24.12 Z24 OCF 3 H H C-24.13 Z24 OCF 2 H H H C-24.14 Z24 Cl H F C-24.15 Z24 CH 3 H F C-24.16 Z24 CH 3 F H C-24.17 Z24 Cl F H C-24.18 Z24 F F H C-24.19 Z24 F H F C-24.20 Z24 F H Cl C-24.21 Z24 F H CH 3 C-24.22 Z24 Cl H CH 3 C-24.23 Z24 SCH 3 H H C-24.24 Z24 SO 2 CH 3 H H C-24.25 Z24 ethynyl H H C-25.1\u2002 Z25, R a  is H H H H C-25.2\u2002 Z25, R a  is H CH 3 H H C-25.3\u2002 Z25, R a  is H Cl H H C-25.4\u2002 Z25, R a  is H F H H C-25.5\u2002 Z25, R a  is H CH 2 CH 3 H H C-25.6\u2002 Z25, R a  is H CF 2 H H H C-25.7\u2002 Z25, R a  is H CH 2 F H H C-25.8\u2002 Z25, R a  is H CF 3 H H C-25.9\u2002 Z25, R a  is H CF 2 CH 3 H H C-25.10 Z25, R a  is H CH 2 CF 3 H H C-25.11 Z25, R a  is H cyclopropyl H H C-25.12 Z25, R a  is H OCF 3 H H C-25.13 Z25, R a  is H OCF 2 H H H C-25.14 Z25, R a  is H Cl H F C-25.15 Z25, R a  is H CH 3 H F C-25.16 Z25, R a  is H CH 3 F H C-25.17 Z25, R a  is H Cl F H C-25.18 Z25, R a  is H F F H C-25.19 Z25, R a  is H F H F C-25.20 Z25, R a  is H F H Cl C-25.21 Z25, R a  is H F H CH 3 C-25.22 Z25, R a  is H Cl H CH 3 C-25.23 Z25, R a  is H SCH 3 H H C-25.24 Z25, R a  is H SO 2 CH 3 H H C-25.25 Z25, R a  is H ethynyl H H C-26.1\u2002 Z26, R a  is H H H H C-26.2\u2002 Z26, R a  is H CH 3 H H C-26.3\u2002 Z26, R a  is H Cl H H C-26.4\u2002 Z26, R a  is H F H H C-26.5\u2002 Z26, R a  is H CH 2 CH 3 H H C-26.6\u2002 Z26, R a  is H CF 2 H H H C-26.7\u2002 Z26, R a  is H CH 2 F H H C-26.8\u2002 Z26, R a  is H CF 3 H H C-26.9\u2002 Z26, R a  is H CF 2 CH 3 H H C-26.10 Z26, R a  is H CH 2 CF 3 H H C-26.11 Z26, R a  is H cyclopropyl H H C-26.12 Z26, R a  is H OCF 3 H H C-26.13 Z26, R a  is H OCF 2 H H H C-26.14 Z26, R a  is H Cl H F C-26.15 Z26, R a  is H CH 3 H F C-26.16 Z26, R a  is H CH 3 F H C-26.17 Z26, R a  is H Cl F H C-26.18 Z26, R a  is H F F H C-26.19 Z26, R a  is H F H F C-26.20 Z26, R a  is H F H Cl C-26.21 Z26, R a  is H F H CH 3 C-26.22 Z26, R a  is H Cl H CH 3 C-26.23 Z26, R a  is H SCH 3 H H C-26.24 Z26, R a  is H SO 2 CH 3 H H C-26.25 Z26, R a  is H ethynyl H H C-27.1\u2002 Z27 H H H C-27.2\u2002 Z27 CH 3 H H C-27.3\u2002 Z27 Cl H H C-27.4\u2002 Z27 F H H C-27.5\u2002 Z27 CH 2 CH 3 H H C-27.6\u2002 Z27 CF 2 H H H C-27.7\u2002 Z27 CH 2 F H H C-27.8\u2002 Z27 CF 3 H H C-27.9\u2002 Z27 CF 2 CH 3 H H C-27.10 Z27 CH 2 CF 3 H H C-27.11 Z27 cyclopropyl H H C-27.12 Z27 OCF 3 H H C-27.13 Z27 OCF 2 H H H C-27.14 Z27 Cl H F C-27.15 Z27 CH 3 H F C-27.16 Z27 CH 3 F H C-27.17 Z27 Cl F H C-27.18 Z27 F F H C-27.19 Z27 F H F C-27.20 Z27 F H Cl C-27.21 Z27 F H CH 3 C-27.22 Z27 Cl H CH 3 C-27.23 Z27 SCH 3 H H C-27.24 Z27 SO 2 CH 3 H H C-27.25 Z27 ethynyl H H C-28.1\u2002 Z28 H H H C-28.2\u2002 Z28 CH 3 H H C-28.3\u2002 Z28 Cl H H C-28.4\u2002 Z28 F H H C-28.5\u2002 Z28 CH 2 CH 3 H H C-28.6\u2002 Z28 CF 2 H H H C-28.7\u2002 Z28 CH 2 F H H C-28.8\u2002 Z28 CF 3 H H C-28.9\u2002 Z28 CF 2 CH 3 H H C-28.10 Z28 CH 2 CF 3 H H C-28.11 Z28 cyclopropyl H H C-28.12 Z28 OCF 3 H H C-28.13 Z28 OCF 2 H H H C-28.14 Z28 Cl H F C-28.15 Z28 CH 3 H F C-28.16 Z28 CH 3 F H C-28.17 Z28 Cl F H C-28.18 Z28 F F H C-28.19 Z28 F H F C-28.20 Z28 F H Cl C-28.21 Z28 F H CH 3 C-28.22 Z28 Cl H CH 3 C-28.23 Z28 SCH 3 H H C-28.24 Z28 SO 2 CH 3 H H C-28.25 Z28 ethynyl H H C-29.1\u2002 Z29 H H H C-29.2\u2002 Z29 CH 3 H H C-29.3\u2002 Z29 Cl H H C-29.4\u2002 Z29 F H H C-29.5\u2002 Z29 CH 2 CH 3 H H C-29.6\u2002 Z29 CF 2 H H H C-29.7\u2002 Z29 CH 2 F H H C-29.8\u2002 Z29 CF 3 H H C-29.9\u2002 Z29 CF 2 CH 3 H H C-29.10 Z29 CH 2 CF 3 H H C-29.11 Z29 cyclopropyl H H C-29.12 Z29 OCF 3 H H C-29.13 Z29 OCF 2 H H H C-29.14 Z29 Cl H F C-29.15 Z29 CH 3 H F C-29.16 Z29 CH 3 F H C-29.17 Z29 Cl F H C-29.18 Z29 F F H C-29.19 Z29 F H F C-29.20 Z29 F H Cl C-29.21 Z29 F H CH 3 C-29.22 Z29 Cl H CH 3 C-29.23 Z29 SCH 3 H H C-29.24 Z29 SO 2 CH 3 H H C-29.25 Z29 ethynyl H H C-30.1\u2002 Z30 H H H C-30.2\u2002 Z30 CH 3 H H C-30.3\u2002 Z30 Cl H H C-30.4\u2002 Z30 F H H C-30.5\u2002 Z30 CH 2 CH 3 H H C-30.6\u2002 Z30 CF 2 H H H C-30.7\u2002 Z30 CH 2 F H H C-30.8\u2002 Z30 CF 3 H H C-30.9\u2002 Z30 CF 2 CH 3 H H C-30.10 Z30 CH 2 CF 3 H H C-30.11 Z30 cyclopropyl H H C-30.12 Z30 OCF 3 H H C-30.13 Z30 OCF 2 H H H C-30.14 Z30 Cl H F C-30.15 Z30 CH 3 H F C-30.16 Z30 CH 3 F H C-30.17 Z30 Cl F H C-30.18 Z30 F F H C-30.19 Z30 F H F C-30.20 Z30 F H Cl C-30.21 Z30 F H CH 3 C-30.22 Z30 Cl H CH 3 C-30.23 Z30 SCH 3 H H C-30.24 Z30 SO 2 CH 3 H H C-30.25 Z30 ethynyl H H C-31.1\u2002 Z31 H H H C-31.2\u2002 Z31 CH 3 H H C-31.3\u2002 Z31 Cl H H C-31.4\u2002 Z31 F H H C-31.5\u2002 Z31 CH 2 CH 3 H H C-31.6\u2002 Z31 CF 2 H H H C-31.7\u2002 Z31 CH 2 F H H C-31.8\u2002 Z31 CF 3 H H C-31.9\u2002 Z31 CF 2 CH 3 H H C-31.10 Z31 CH 2 CF 3 H H C-31.11 Z31 cyclopropyl H H C-31.12 Z31 OCF 3 H H C-31.13 Z31 OCF 2 H H H C-31.14 Z31 Cl H F C-31.15 Z31 CH 3 H F C-31.16 Z31 CH 3 F H C-31.17 Z31 Cl F H C-31.18 Z31 F F H C-31.19 Z31 F H F C-31.20 Z31 F H Cl C-31.21 Z31 F H CH 3 C-31.22 Z31 Cl H CH 3 C-31.23 Z31 SCH 3 H H C-31.24 Z31 SO 2 CH 3 H H C-31.25 Z31 ethynyl H H C-32.1\u2002 Z32 H H H C-32.2\u2002 Z32 CH 3 H H C-32.3\u2002 Z32 Cl H H C-32.4\u2002 Z32 F H H C-32.5\u2002 Z32 CH 2 CH 3 H H C-32.6\u2002 Z32 CF 2 H H H C-32.7\u2002 Z32 CH 2 F H H C-32.8\u2002 Z32 CF 3 H H C-32.9\u2002 Z32 CF 2 CH 3 H H C-32.10 Z32 CH 2 CF 3 H H C-32.11 Z32 cyclopropyl H H C-32.12 Z32 OCF 3 H H C-32.13 Z32 OCF 2 H H H C-32.14 Z32 Cl H F C-32.15 Z32 CH 3 H F C-32.16 Z32 CH 3 F H C-32.17 Z32 Cl F H C-32.18 Z32 F F H C-32.19 Z32 F H F C-32.20 Z32 F H Cl C-32.21 Z32 F H CH 3 C-32.22 Z32 Cl H CH 3 C-32.23 Z32 SCH 3 H H C-32.24 Z32 SO 2 CH 3 H H C-32.25 Z32 ethynyl H H C-33.1\u2002 Z33 H H H C-33.2\u2002 Z33 CH 3 H H C-33.3\u2002 Z33 Cl H H C-33.4\u2002 Z33 F H H C-33.5\u2002 Z33 CH 2 CH 3 H H C-33.6\u2002 Z33 CF 2 H H H C-33.7\u2002 Z33 CH 2 F H H C-33.8\u2002 Z33 CF 3 H H C-33.9\u2002 Z33 CF 2 CH 3 H H C-33.10 Z33 CH 2 CF 3 H H C-33.11 Z33 cyclopropyl H H C-33.12 Z33 OCF 3 H H C-33.13 Z33 OCF 2 H H H C-33.14 Z33 Cl H F C-33.15 Z33 CH 3 H F C-33.16 Z33 CH 3 F H C-33.17 Z33 Cl F H C-33.18 Z33 F F H C-33.19 Z33 F H F C-33.20 Z33 F H Cl C-33.21 Z33 F H CH 3 C-33.22 Z33 Cl H CH 3 C-33.23 Z33 SCH 3 H H C-33.24 Z33 SO 2 CH 3 H H C-33.25 Z33 ethynyl H H C-34.1\u2002 Z34 H H H C-34.2\u2002 Z34 CH 3 H H C-34.3\u2002 Z34 Cl H H C-34.4\u2002 Z34 F H H C-34.5\u2002 Z34 CH 2 CH 3 H H C-34.6\u2002 Z34 CF 2 H H H C-34.7\u2002 Z34 CH 2 F H H C-34.8\u2002 Z34 CF 3 H H C-34.9\u2002 Z34 CF 2 CH 3 H H C-34.10 Z34 CH 2 CF 3 H H C-34.11 Z34 cyclopropyl H H C-34.12 Z34 OCF 3 H H C-34.13 Z34 OCF 2 H H H C-34.14 Z34 Cl H F C-34.15 Z34 CH 3 H F C-34.16 Z34 CH 3 F H C-34.17 Z34 Cl F H C-34.18 Z34 F F H C-34.19 Z34 F H F C-34.20 Z34 F H Cl C-34.21 Z34 F H CH 3 C-34.22 Z34 Cl H CH 3 C-34.23 Z34 SCH 3 H H C-34.24 Z34 SO 2 CH 3 H H C-34.25 Z34 ethynyl H H C-35.1\u2002 Z35, R a  is H H H H C-35.2\u2002 Z35, R a  is H CH 3 H H C-35.3\u2002 Z35, R a  is H Cl H H C-35.4\u2002 Z35, R a  is H F H H C-35.5\u2002 Z35, R a  is H CH 2 CH 3 H H C-35.6\u2002 Z35, R a  is H CF 2 H H H C-35.7\u2002 Z35, R a  is H CH 2 F H H C-35.8\u2002 Z35, R a  is H CF 3 H H C-35.9\u2002 Z35, R a  is H CF 2 CH 3 H H C-35.10 Z35, R a  is H CH 2 CF 3 H H C-35.11 Z35, R a  is H cyclopropyl H H C-35.12 Z35, R a  is H OCF 3 H H C-35.13 Z35, R a  is H OCF 2 H H H C-35.14 Z35, R a  is H Cl H F C-35.15 Z35, R a  is H CH 3 H F C-35.16 Z35, R a  is H CH 3 F H C-35.17 Z35, R a  is H Cl F H C-35.18 Z35, R a  is H F F H C-35.19 Z35, R a  is H F H F C-35.20 Z35, R a  is H F H Cl C-35.21 Z35, R a  is H F H CH 3 C-35.22 Z35, R a  is H Cl H CH 3 C-35.23 Z35, R a  is H SCH 3 H H C-35.24 Z35, R a  is H SO 2 CH 3 H H C-35.25 Z35, R a  is H ethynyl H H C-36.1\u2002 Z36, R a  is H H H H C-36.2\u2002 Z36, R a  is H CH 3 H H C-36.3\u2002 Z36, R a  is H Cl H H C-36.4\u2002 Z36, R a  is H F H H C-36.5\u2002 Z36, R a  is H CH 2 CH 3 H H C-36.6\u2002 Z36, R a  is H CF 2 H H H C-36.7\u2002 Z36, R a  is H CH 2 F H H C-36.8\u2002 Z36, R a  is H CF 3 H H C-36.9\u2002 Z36, R a  is H CF 2 CH 3 H H C-36.10 Z36, R a  is H CH 2 CF 3 H H C-36.11 Z36, R a  is H cyclopropyl H H C-36.12 Z36, R a  is H OCF 3 H H C-36.13 Z36, R a  is H OCF 2 H H H C-36.14 Z36, R a  is H Cl H F C-36.15 Z36, R a  is H CH 3 H F C-36.16 Z36, R a  is H CH 3 F H C-36.17 Z36, R a  is H Cl F H C-36.18 Z36, R a  is H F F H C-36.19 Z36, R a  is H F H F C-36.20 Z36, R a  is H F H Cl C-36.21 Z36, R a  is H F H CH 3 C-36.22 Z36, R a  is H Cl H CH 3 C-36.23 Z36, R a  is H SCH 3 H H C-36.24 Z36, R a  is H SO 2 CH 3 H H C-36.25 Z36, R a  is H ethynyl H H TABLE 1.E1 (R)   compound Z R 5 R 6 R 7 E1-1.1 Z1 H H H E1-1.2 Z1 CH 3 H H E1-1.3 Z1 Cl H H E1-1.4 Z1 F H H E1-1.5 Z1 CH 2 CH 3 H H E1-1.6 Z1 CF 2 H H H E1-1.7 Z1 CH 2 F H H E1-1.8 Z1 CF 3 H H E1-1.9 Z1 CF 2 CH 3 H H E1-1.10 Z1 CH 2 CF 3 H H E1-1.11 Z1 cyclopropyl H H E1-1.12 Z1 OCF 3 H H E1-1.13 Z1 OCF 2 H H H E1-1.14 Z1 Cl H F E1-1.15 Z1 CH 3 H F E1-1.16 Z1 CH 3 F H E1-1.17 Z1 Cl F H E1-1.18 Z1 F F H E1-1.19 Z1 F H F E1-1.20 Z1 F H Cl E1-1.21 Z1 F H CH 3 E1-1.22 Z1 Cl H CH 3 E1-1.23 Z1 SCH 3 H H E1-1.24 Z1 SO 2 CH 3 H H E1-1.25 Z1 ethynyl H H E1-2.1 Z2 H H H E1-2.2 Z2 CH 3 H H E1-2.3 Z2 Cl H H E1-2.4 Z2 F H H E1-2.5 Z2 CH 2 CH 3 H H E1-2.6 Z2 CF 2 H H H E1-2.7 Z2 CH 2 F H H E1-2.8 Z2 CF 3 H H E1-2.9 Z2 CF 2 CH 3 H H E1-2.10 Z2 CH 2 CF 3 H H E1-2.11 Z2 cyclopropyl H H E1-2.12 Z2 OCF 3 H H E1-2.13 Z2 OCF 2 H H H E1-2.14 Z2 Cl H F E1-2.15 Z2 CH 3 H F E1-2.16 Z2 CH 3 F H E1-2.17 Z2 Cl F H E1-2.18 Z2 F F H E1-2.19 Z2 F H F E1-2.20 Z2 F H Cl E1-2.21 Z2 F H CH 3 E1-2.22 Z2 Cl H CH 3 E1-2.23 Z2 SCH 3 H H E1-2.24 Z2 SO 2 CH 3 H H E1-2.25 Z2 ethynyl H H E1-3.1 Z3 H H H E1-3.2 Z3 CH 3 H H E1-3.3 Z3 Cl H H E1-3.4 Z3 F H H E1-3.5 Z3 CH 2 CH 3 H H E1-3.6 Z3 CF 2 H H H E1-3.7 Z3 CH 2 F H H E1-3.8 Z3 CF 3 H H E1-3.9 Z3 CF 2 CH 3 H H E1-3.10 Z3 CH 2 CF 3 H H E1-3.11 Z3 cyclopropyl H H E1-3.12 Z3 OCF 3 H H E1-3.13 Z3 OCF 2 H H H E1-3.14 Z3 Cl H F E1-3.15 Z3 CH 3 H F E1-3.16 Z3 CH 3 F H E1-3.17 Z3 Cl F H E1-3.18 Z3 F F H E1-3.19 Z3 F H F E1-3.20 Z3 F H Cl E1-3.21 Z3 F H CH 3 E1-3.22 Z3 Cl H CH 3 E1-3.23 Z3 SCH 3 H H E1-3.24 Z3 SO 2 CH 3 H H E1-3.25 Z3 ethynyl H H E1-4.1 Z4 H H H E1-4.2 Z4 CH 3 H H E1-4.3 Z4 Cl H H E1-4.4 Z4 F H H E1-4.5 Z4 CH 2 CH 3 H H E1-4.6 Z4 CF 2 H H H E1-4.7 Z4 CH 2 F H H E1-4.8 Z4 CF 3 H H E1-4.9 Z4 CF 2 CH 3 H H E1-4.10 Z4 CH 2 CF 3 H H E1-4.11 Z4 cyclopropyl H H E1-4.12 Z4 OCF 3 H H E1-4.13 Z4 OCF 2 H H H E1-4.14 Z4 Cl H F E1-4.15 Z4 CH 3 H F E1-4.16 Z4 CH 3 F H E1-4.17 Z4 Cl F H E1-4.18 Z4 F F H E1-4.19 Z4 F H F E1-4.20 Z4 F H Cl E1-4.21 Z4 F H CH 3 E1-4.22 Z4 Cl H CH 3 E1-4.23 Z4 SCH 3 H H E1-4.24 Z4 SO 2 CH 3 H H E1-4.25 Z4 ethynyl H H E1-5.1 Z5 H H H E1-5.2 Z5 CH 3 H H E1-5.3 Z5 Cl H H E1-5.4 Z5 F H H E1-5.5 Z5 CH 2 CH 3 H H E1-5.6 Z5 CF 2 H H H E1-5.7 Z5 CH 2 F H H E1-5.8 Z5 CF 3 H H E1-5.9 Z5 CF 2 CH 3 H H E1-5.10 Z5 CH 2 CF 3 H H E1-5.11 Z5 cyclopropyl H H E1-5.12 Z5 OCF 3 H H E1-5.13 Z5 OCF 2 H H H E1-5.14 Z5 Cl H F E1-5.15 Z5 CH 3 H F E1-5.16 Z5 CH 3 F H E1-5.17 Z5 Cl F H E1-5.18 Z5 F F H E1-5.19 Z5 F H F E1-5.20 Z5 F H Cl E1-5.21 Z5 F H CH 3 E1-5.22 Z5 Cl H CH 3 E1-5.23 Z5 SCH 3 H H E1-5.24 Z5 SO 2 CH 3 H H E1-5.25 Z5 ethynyl H H E1-6.1 Z6, R a  is H H H H E1-6.2 Z6, R a  is H CH 3 H H E1-6.3 Z6, R a  is H Cl H H E1-6.4 Z6, R a  is H F H H E1-6.5 Z6, R a  is H CH 2 CH 3 H H E1-6.6 Z6, R a  is H CF 2 H H H E1-6.7 Z6, R a  is H CH 2 F H H E1-6.8 Z6, R a  is H CF 3 H H E1-6.9 Z6, R a  is H CF 2 CH 3 H H E1-6.10 Z6, R a  is H CH 2 CF 3 H H E1-6.11 Z6, R a  is H cyclopropyl H H E1-6.12 Z6, R a  is H OCF 3 H H E1-6.13 Z6, R a  is H OCF 2 H H H E1-6.14 Z6, R a  is H Cl H F E1-6.15 Z6, R a  is H CH 3 H F E1-6.16 Z6, R a  is H CH 3 F H E1-6.17 Z6, R a  is H Cl F H E1-6.18 Z6, R a  is H F F H E1-6.19 Z6, R a  is H F H F E1-6.20 Z6, R a  is H F H Cl E1-6.21 Z6, R a  is H F H CH 3 E1-6.22 Z6, R a  is H Cl H CH 3 E1-6.23 Z6, R a  is H SCH 3 H H E1-6.24 Z6, R a  is H SO 2 CH 3 H H E1-6.25 Z6, R a  is H ethynyl H H E1-7.1 Z7, R a  is H H H H E1-7.2 Z7, R a  is H CH 3 H H E1-7.3 Z7, R a  is H Cl H H E1-7.4 Z7, R a  is H F H H E1-7.5 Z7, R a  is H CH 2 CH 3 H H E1-7.6 Z7, R a  is H CF 2 H H H E1-7.7 Z7, R a  is H CH 2 F H H E1-7.8 Z7, R a  is H CF 3 H H E1-7.9 Z7, R a  is H CF 2 CH 3 H H E1-7.10 Z7, R a  is H CH 2 CF 3 H H E1-7.11 Z7, R a  is H cyclopropyl H H E1-7.12 Z7, R a  is H OCF 3 H H E1-7.13 Z7, R a  is H OCF 2 H H H E1-7.14 Z7, R a  is H Cl H F E1-7.15 Z7, R a  is H CH 3 H F E1-7.16 Z7, R a  is H CH 3 F H E1-7.17 Z7, R a  is H Cl F H E1-7.18 Z7, R a  is H F F H E1-7.19 Z7, R a  is H F H F E1-7.20 Z7, R a  is H F H Cl E1-7.21 Z7, R a  is H F H CH 3 E1-7.22 Z7, R a  is H Cl H CH 3 E1-7.23 Z7, R a  is H SCH 3 H H E1-7.24 Z7, R a  is H SO 2 CH 3 H H E1-7.25 Z7, R a  is H ethynyl H H E1-8.1 Z8, R a  is H H H H E1-8.2 Z8, R a  is H CH 3 H H E1-8.3 Z8, R a  is H Cl H H E1-8.4 Z8, R a  is H F H H E1-8.5 Z8, R a  is H CH 2 CH 3 H H E1-8.6 Z8, R a  is H CF 2 H H H E1-8.7 Z8, R a  is H CH 2 F H H E1-8.8 Z8, R a  is H CF 3 H H E1-8.9 Z8, R a  is H CF 2 CH 3 H H E1-8.10 Z8, R a  is H CH 2 CF 3 H H E1-8.11 Z8, R a  is H cyclopropyl H H E1-8.12 Z8, R a  is H OCF 3 H H E1-8.13 Z8, R a  is H OCF 2 H H H E1-8.14 Z8, R a  is H Cl H F E1-8.15 Z8, R a  is H CH 3 H F E1-8.16 Z8, R a  is H CH 3 F H E1-8.17 Z8, R a  is H Cl F H E1-8.18 Z8, R a  is H F F H E1-8.19 Z8, R a  is H F H F E1-8.20 Z8, R a  is H F H Cl E1-8.21 Z8, R a  is H F H CH 3 E1-8.22 Z8, R a  is H Cl H CH 3 E1-8.23 Z8, R a  is H SCH 3 H H E1-8.24 Z8, R a  is H SO 2 CH 3 H H E1-8.25 Z8, R a  is H ethynyl H H E1-9.1 Z9 H H H E1-9.2 Z9 CH 3 H H E1-9.3 Z9 Cl H H E1-9.4 Z9 F H H E1-9.5 Z9 CH 2 CH 3 H H E1-9.6 Z9 CF 2 H H H E1-9.7 Z9 CH 2 F H H E1-9.8 Z9 CF 3 H H E1-9.9 Z9 CF 2 CH 3 H H E1-9.10 Z9 CH 2 CF 3 H H E1-9.11 Z9 cyclopropyl H H E1-9.12 Z9 OCF 3 H H E1-9.13 Z9 OCF 2 H H H E1-9.14 Z9 Cl H F E1-9.15 Z9 CH 3 H F E1-9.16 Z9 CH 3 F H E1-9.17 Z9 Cl F H E1-9.18 Z9 F F H E1-9.19 Z9 F H F E1-9.20 Z9 F H Cl E1-9.21 Z9 F H CH 3 E1-9.22 Z9 Cl H CH 3 E1-9.23 Z9 SCH 3 H H E1-9.24 Z9 SO 2 CH 3 H H E1-9.25 Z9 ethynyl H H E1-10.1 Z10 H H H E1-10.2 Z10 CH 3 H H E1-10.3 Z10 Cl H H E1-10.4 Z10 F H H E1-10.5 Z10 CH 2 CH 3 H H E1-10.6 Z10 CF 2 H H H E1-10.7 Z10 CH 2 F H H E1-10.8 Z10 CF 3 H H E1-10.9 Z10 CF 2 CH 3 H H E1-10.10 Z10 CH 2 CF 3 H H E1-10.11 Z10 cyclopropyl H H E1-10.12 Z10 OCF 3 H H E1-10.13 Z10 OCF 2 H H H E1-10.14 Z10 Cl H F E1-10.15 Z10 CH 3 H F E1-10.16 Z10 CH 3 F H E1-10.17 Z10 Cl F H E1-10.18 Z10 F F H E1-10.19 Z10 F H F E1-10.20 Z10 F H Cl E1-10.21 Z10 F H CH 3 E1-10.22 Z10 Cl H CH 3 E1-10.23 Z10 SCH 3 H H E1-10.24 Z10 SO 2 CH 3 H H E1-10.25 Z10 ethynyl H H E1-11.1 Z11, R a  is H H H H E1-11.2 Z11, R a  is H CH 3 H H E1-11.3 Z11, R a  is H Cl H H E1-11.4 Z11, R a  is H F H H E1-11.5 Z11, R a  is H CH 2 CH 3 H H E1-11.6 Z11, R a  is H CF 2 H H H E1-11.7 Z11, R a  is H CH 2 F H H E1-11.8 Z11, R a  is H CF 3 H H E1-11.9 Z11, R a  is H CF 2 CH 3 H H E1-11.10 Z11, R a  is H CH 2 CF 3 H H E1-11.11 Z11, R a  is H cyclopropyl H H E1-11.12 Z11, R a  is H OCF 3 H H E1-11.13 Z11, R a  is H OCF 2 H H H E1-11.14 Z11, R a  is H Cl H F E1-11.15 Z11, R a  is H CH 3 H F E1-11.16 Z11, R a  is H CH 3 F H E1-11.17 Z11, R a  is H Cl F H E1-11.18 Z11, R a  is H F F H E1-11.19 Z11, R a  is H F H F E1-11.20 Z11, R a  is H F H Cl E1-11.21 Z11, R a  is H F H CH 3 E1-11.22 Z11, R a  is H Cl H CH 3 E1-11.23 Z11, R a  is H SCH 3 H H E1-11.24 Z11, R a  is H SO 2 CH 3 H H E1-11.25 Z11, R a  is H ethynyl H H E1-12.1 Z12 H H H E1-12.2 Z12 CH 3 H H E1-12.3 Z12 Cl H H E1-12.4 Z12 F H H E1-12.5 Z12 CH 2 CH 3 H H E1-12.6 Z12 CF 2 H H H E1-12.7 Z12 CH 2 F H H E1-12.8 Z12 CF 3 H H E1-12.9 Z12 CF 2 CH 3 H H E1-12.10 Z12 CH 2 CF 3 H H E1-12.11 Z12 cyclopropyl H H E1-12.12 Z12 OCF 3 H H E1-12.13 Z12 OCF 2 H H H E1-12.14 Z12 Cl H F E1-12.15 Z12 CH 3 H F E1-12.16 Z12 CH 3 F H E1-12.17 Z12 Cl F H E1-12.18 Z12 F F H E1-12.19 Z12 F H F E1-12.20 Z12 F H Cl E1-12.21 Z12 F H CH 3 E1-12.22 Z12 Cl H CH 3 E1-12.23 Z12 SCH 3 H H E1-12.24 Z12 SO 2 CH 3 H H E1-12.25 Z12 ethynyl H H E1-13.1 Z13, R a  is H H H H E1-13.2 Z13, R a  is H CH 3 H H E1-13.3 Z13, R a  is H Cl H H E1-13.4 Z13, R a  is H F H H E1-13.5 Z13, R a  is H CH 2 CH 3 H H E1-13.6 Z13, R a  is H CF 2 H H H E1-13.7 Z13, R a  is H CH 2 F H H E1-13.8 Z13, R a  is H CF 3 H H E1-13.9 Z13, R a  is H CF 2 CH 3 H H E1-13.10 Z13, R a  is H CH 2 CF 3 H H E1-13.11 Z13, R a  is H cyclopropyl H H E1-13.12 Z13, R a  is H OCF 3 H H E1-13.13 Z13, R a  is H OCF 2 H H H E1-13.14 Z13, R a  is H Cl H F E1-13.15 Z13, R a  is H CH 3 H F E1-13.16 Z13, R a  is H CH 3 F H E1-13.17 Z13, R a  is H Cl F H E1-13.18 Z13, R a  is H F F H E1-13.19 Z13, R a  is H F H F E1-13.20 Z13, R a  is H F H Cl E1-13.21 Z13, R a  is H F H CH 3 E1-13.22 Z13, R a  is H Cl H CH 3 E1-13.23 Z13, R a  is H SCH 3 H H E1-13.24 Z13, R a  is H SO 2 CH 3 H H E1-13.25 Z13, R a  is H ethynyl H H E1-14.1 Z14, R a  is H H H H E1-14.2 Z14, R a  is H CH 3 H H E1-14.3 Z14, R a  is H Cl H H E1-14.4 Z14, R a  is H F H H E1-14.5 Z14, R a  is H CH 2 CH 3 H H E1-14.6 Z14, R a  is H CF 2 H H H E1-14.7 Z14, R a  is H CH 2 F H H E1-14.8 Z14, R a  is H CF 3 H H E1-14.9 Z14, R a  is H CF 2 CH 3 H H E1-14.10 Z14, R a  is H CH 2 CF 3 H H E1-14.11 Z14, R a  is H cyclopropyl H H E1-14.12 Z14, R a  is H OCF 3 H H E1-14.13 Z14, R a  is H OCF 2 H H H E1-14.14 Z14, R a  is H Cl H F E1-14.15 Z14, R a  is H CH 3 H F E1-14.16 Z14, R a  is H CH 3 F H E1-14.17 Z14, R a  is H Cl F H E1-14.18 Z14, R a  is H F F H E1-14.19 Z14, R a  is H F H F E1-14.20 Z14, R a  is H F H Cl E1-14.21 Z14, R a  is H F H CH 3 E1-14.22 Z14, R a  is H Cl H CH 3 E1-14.23 Z14, R a  is H SCH 3 H H E1-14.24 Z14, R a  is H SO 2 CH 3 H H E1-14.25 Z14, R a  is H ethynyl H H E1-15.1 Z15, R a  is H H H H E1-15.2 Z15, R a  is H CH 3 H H E1-15.3 Z15, R a  is H Cl H H E1-15.4 Z15, R a  is H F H H E1-15.5 Z15, R a  is H CH 2 CH 3 H H E1-15.6 Z15, R a  is H CF 2 H H H E1-15.7 Z15, R a  is H CH 2 F H H E1-15.8 Z15, R a  is H CF 3 H H E1-15.9 Z15, R a  is H CF 2 CH 3 H H E1-15.10 Z15, R a  is H CH 2 CF 3 H H E1-15.11 Z15, R a  is H cyclopropyl H H E1-15.12 Z15, R a  is H OCF 3 H H E1-15.13 Z15, R a  is H OCF 2 H H H E1-15.14 Z15, R a  is H Cl H F E1-15.15 Z15, R a  is H CH 3 H F E1-15.16 Z15, R a  is H CH 3 F H E1-15.17 Z15, R a  is H Cl F H E1-15.18 Z15, R a  is H F F H E1-15.19 Z15, R a  is H F H F E1-15.20 Z15, R a  is H F H Cl E1-15.21 Z15, R a  is H F H CH 3 E1-15.22 Z15, R a  is H Cl H CH 3 E1-15.23 Z15, R a  is H SCH 3 H H E1-15.24 Z15, R a  is H SO 2 CH 3 H H E1-15.25 Z15, R a  is H ethynyl H H E1-16.1 Z16, R a  is H H H H E1-16.2 Z16, R a  is H CH 3 H H E1-16.3 Z16, R a  is H Cl H H E1-16.4 Z16, R a  is H F H H E1-16.5 Z16, R a  is H CH 2 CH 3 H H E1-16.6 Z16, R a  is H CF 2 H H H E1-16.7 Z16, R a  is H CH 2 F H H E1-16.8 Z16, R a  is H CF 3 H H E1-16.9 Z16, R a  is H CF 2 CH 3 H H E1-16.10 Z16, R a  is H CH 2 CF 3 H H E1-16.11 Z16, R a  is H cyclopropyl H H E1-16.12 Z16, R a  is H OCF 3 H H E1-16.13 Z16, R a  is H OCF 2 H H H E1-16.14 Z16, R a  is H Cl H F E1-16.15 Z16, R a  is H CH 3 H F E1-16.16 Z16, R a  is H CH 3 F H E1-16.17 Z16, R a  is H Cl F H E1-16.18 Z16, R a  is H F F H E1-16.19 Z16, R a  is H F H F E1-16.20 Z16, R a  is H F H Cl E1-16.21 Z16, R a  is H F H CH 3 E1-16.22 Z16, R a  is H Cl H CH 3 E1-16.23 Z16, R a  is H SCH 3 H H E1-16.24 Z16, R a  is H SO 2 CH 3 H H E1-16.25 Z16, R a  is H ethynyl H H E1-17.1 Z17 H H H E1-17.2 Z17 CH 3 H H E1-17.3 Z17 Cl H H E1-17.4 Z17 F H H E1-17.5 Z17 CH 2 CH 3 H H E1-17.6 Z17 CF 2 H H H E1-17.7 Z17 CH 2 F H H E1-17.8 Z17 CF 3 H H E1-17.9 Z17 CF 2 CH 3 H H E1-17.10 Z17 CH 2 CF 3 H H E1-17.11 Z17 cyclopropyl H H E1-17.12 Z17 OCF 3 H H E1-17.13 Z17 OCF 2 H H H E1-17.14 Z17 Cl H F E1-17.15 Z17 CH 3 H F E1-17.16 Z17 CH 3 F H E1-17.17 Z17 Cl F H E1-17.18 Z17 F F H E1-17.19 Z17 F H F E1-17.20 Z17 F H Cl E1-17.21 Z17 F H CH 3 E1-17.22 Z17 Cl H CH 3 E1-17.23 Z17 SCH 3 H H E1-17.24 Z17 SO 2 CH 3 H H E1-17.25 Z17 ethynyl H H E1-18.1 Z18 H H H E1-18.2 Z18 CH 3 H H E1-18.3 Z18 Cl H H E1-18.4 Z18 F H H E1-18.5 Z18 CH 2 CH 3 H H E1-18.6 Z18 CF 2 H H H E1-18.7 Z18 CH 2 F H H E1-18.8 Z18 CF 3 H H E1-18.9 Z18 CF 2 CH 3 H H E1-18.10 Z18 CH 2 CF 3 H H E1-18.11 Z18 cyclopropyl H H E1-18.12 Z18 OCF 3 H H E1-18.13 Z18 OCF 2 H H H E1-18.14 Z18 Cl H F E1-18.15 Z18 CH 3 H F E1-18.16 Z18 CH 3 F H E1-18.17 Z18 Cl F H E1-18.18 Z18 F F H E1-18.19 Z18 F H F E1-18.20 Z18 F H Cl E1-18.21 Z18 F H CH 3 E1-18.22 Z18 Cl H CH 3 E1-18.23 Z18 SCH 3 H H E1-18.24 Z18 SO 2 CH 3 H H E1-18.25 Z18 ethynyl H H E1-19.1 Z19 H H H E1-19.2 Z19 CH 3 H H E1-19.3 Z19 Cl H H E1-19.4 Z19 F H H E1-19.5 Z19 CH 2 CH 3 H H E1-19.6 Z19 CF 2 H H H E1-19.7 Z19 CH 2 F H H E1-19.8 Z19 CF 3 H H E1-19.9 Z19 CF 2 CH 3 H H E1-19.10 Z19 CH 2 CF 3 H H E1-19.11 Z19 cyclopropyl H H E1-19.12 Z19 OCF 3 H H E1-19.13 Z19 OCF 2 H H H E1-19.14 Z19 Cl H F E1-19.15 Z19 CH 3 H F E1-19.16 Z19 CH 3 F H E1-19.17 Z19 Cl F H E1-19.18 Z19 F F H E1-19.19 Z19 F H F E1-19.20 Z19 F H Cl E1-19.21 Z19 F H CH 3 E1-19.22 Z19 Cl H CH 3 E1-19.23 Z19 SCH 3 H H E1-19.24 Z19 SO 2 CH 3 H H E1-19.25 Z19 ethynyl H H E1-19.26 Z19 CH 3 H H E1-20.1 Z20 H H H E1-20.2 Z20 CH 3 H H E1-20.3 Z20 Cl H H E1-20.4 Z20 F H H E1-20.5 Z20 CH 2 CH 3 H H E1-20.6 Z20 CF 2 H H H E1-20.7 Z20 CH 2 F H H E1-20.8 Z20 CF 3 H H E1-20.9 Z20 CF 2 CH 3 H H E1-20.10 Z20 CH 2 CF 3 H H E1-20.11 Z20 cyclopropyl H H E1-20.12 Z20 OCF 3 H H E1-20.13 Z20 OCF 2 H H H E1-20.14 Z20 Cl H F E1-20.15 Z20 CH 3 H F E1-20.16 Z20 CH 3 F H E1-20.17 Z20 Cl F H E1-20.18 Z20 F F H E1-20.19 Z20 F H F E1-20.20 Z20 F H Cl E1-20.21 Z20 F H CH 3 E1-20.22 Z20 Cl H CH 3 E1-20.23 Z20 SCH 3 H H E1-20.24 Z20 SO 2 CH 3 H H E1-20.25 Z20 ethynyl H H E1-21.1 Z21 H H H E1-21.2 Z21 CH 3 H H E1-21.3 Z21 Cl H H E1-21.4 Z21 F H H E1-21.5 Z21 CH 2 CH 3 H H E1-21.6 Z21 CF 2 H H H E1-21.7 Z21 CH 2 F H H E1-21.8 Z21 CF 3 H H E1-21.9 Z21 CF 2 CH 3 H H E1-21.10 Z21 CH 2 CF 3 H H E1-21.11 Z21 cyclopropyl H H E1-21.12 Z21 OCF 3 H H E1-21.13 Z21 OCF 2 H H H E1-21.14 Z21 Cl H F E1-21.15 Z21 CH 3 H F E1-21.16 Z21 CH 3 F H E1-21.17 Z21 Cl F H E1-21.18 Z21 F F H E1-21.19 Z21 F H F E1-21.20 Z21 F H Cl E1-21.21 Z21 F H CH 3 E1-21.22 Z21 Cl H CH 3 E1-21.23 Z21 SCH 3 H H E1-21.24 Z21 SO 2 CH 3 H H E1-21.25 Z21 ethynyl H H   E1-21.26 \n \u2003 R x  is CH 3 CH 3 H H   E1-22.1 Z22 H H H E1-22.2 Z22 CH 3 H H E1-22.3 Z22 Cl H H E1-22.4 Z22 F H H E1-22.5 Z22 CH 2 CH 3 H H E1-22.6 Z22 CF 2 H H H E1-22.7 Z22 CH 2 F H H E1-22.8 Z22 CF 3 H H E1-22.9 Z22 CF 2 CH 3 H H E1-22.10 Z22 CH 2 CF 3 H H E1-22.11 Z22 cyclopropyl H H E1-22.12 Z22 OCF 3 H H E1-22.13 Z22 OCF 2 H H H E1-22.14 Z22 Cl H F E1-22.15 Z22 CH 3 H F E1-22.16 Z22 CH 3 F H E1-22.17 Z22 Cl F H E1-22.18 Z22 F F H E1-22.19 Z22 F H F E1-22.20 Z22 F H Cl E1-22.21 Z22 F H CH 3 E1-22.22 Z22 Cl H CH 3 E1-22.23 Z22 SCH 3 H H E1-22.24 Z22 SO 2 CH 3 H H E1-22.25 Z22 ethynyl H H E1-23.1 Z23 H H H E1-23.2 Z23 CH 3 H H E1-23.3 Z23 Cl H H E1-23.4 Z23 F H H E1-23.5 Z23 CH 2 CH 3 H H E1-23.6 Z23 CF 2 H H H E1-23.7 Z23 CH 2 F H H E1-23.8 Z23 CF 3 H H E1-23.9 Z23 CF 2 CH 3 H H E1-23.10 Z23 CH 2 CF 3 H H E1-23.11 Z23 cyclopropyl H H E1-23.12 Z23 OCF 3 H H E1-23.13 Z23 OCF 2 H H H E1-23.14 Z23 Cl H F E1-23.15 Z23 CH 3 H F E1-23.16 Z23 CH 3 F H E1-23.17 Z23 Cl F H E1-23.18 Z23 F F H E1-23.19 Z23 F H F E1-23.20 Z23 F H Cl E1-23.21 Z23 F H CH 3 E1-23.22 Z23 Cl H CH 3 E1-23.23 Z23 SCH 3 H H E1-23.24 Z23 SO 2 CH 3 H H E1-23.25 Z23 ethynyl H H E1-24.1 Z24 H H H E1-24.2 Z24 CH 3 H H E1-24.3 Z24 Cl H H E1-24.4 Z24 F H H E1-24.5 Z24 CH 2 CH 3 H H E1-24.6 Z24 CF 2 H H H E1-24.7 Z24 CH 2 F H H E1-24.8 Z24 CF 3 H H E1-24.9 Z24 CF 2 CH 3 H H E1-24.10 Z24 CH 2 CF 3 H H E1-24.11 Z24 cyclopropyl H H E1-24.12 Z24 OCF 3 H H E1-24.13 Z24 OCF 2 H H H E1-24.14 Z24 Cl H F E1-24.15 Z24 CH 3 H F E1-24.16 Z24 CH 3 F H E1-24.17 Z24 Cl F H E1-24.18 Z24 F F H E1-24.19 Z24 F H F E1-24.20 Z24 F H Cl E1-24.21 Z24 F H CH 3 E1-24.22 Z24 Cl H CH 3 E1-24.23 Z24 SCH 3 H H E1-24.24 Z24 SO 2 CH 3 H H E1-24.25 Z24 ethynyl H H E1-25.1 Z25, R a  is H H H H E1-25.2 Z25, R a  is H CH 3 H H E1-25.3 Z25, R a  is H Cl H H E1-25.4 Z25, R a  is H F H H E1-25.5 Z25, R a  is H CH 2 CH 3 H H E1-25.6 Z25, R a  is H CF 2 H H H E1-25.7 Z25, R a  is H CH 2 F H H E1-25.8 Z25, R a  is H CF 3 H H E1-25.9 Z25, R a  is H CF 2 CH 3 H H E1-25.10 Z25, R a  is H CH 2 CF 3 H H E1-25.11 Z25, R a  is H cyclopropyl H H E1-25.12 Z25, R a  is H OCF 3 H H E1-25.13 Z25, R a  is H OCF 2 H H H E1-25.14 Z25, R a  is H Cl H F E1-25.15 Z25, R a  is H CH 3 H F E1-25.16 Z25, R a  is H CH 3 F H E1-25.17 Z25, R a  is H Cl F H E1-25.18 Z25, R a  is H F F H E1-25.19 Z25, R a  is H F H F E1-25.20 Z25, R a  is H F H Cl E1-25.21 Z25, R a  is H F H CH 3 E1-25.22 Z25, R a  is H Cl H CH 3 E1-25.23 Z25, R a  is H SCH 3 H H E1-25.24 Z25, R a  is H SO 2 CH 3 H H E1-25.25 Z25, R a  is H ethynyl H H E1-26.1 Z26, R a  is H H H H E1-26.2 Z26, R a  is H CH 3 H H E1-26.3 Z26, R a  is H Cl H H E1-26.4 Z26, R a  is H F H H E1-26.5 Z26, R a  is H CH 2 CH 3 H H E1-26.6 Z26, R a  is H CF 2 H H H E1-26.7 Z26, R a  is H CH 2 F H H E1-26.8 Z26, R a  is H CF 3 H H E1-26.9 Z26, R a  is H CF 2 CH 3 H H E1-26.10 Z26, R a  is H CH 2 CF 3 H H E1-26.11 Z26, R a  is H cyclopropyl H H E1-26.12 Z26, R a  is H OCF 3 H H E1-26.13 Z26, R a  is H OCF 2 H H H E1-26.14 Z26, R a  is H Cl H F E1-26.15 Z26, R a  is H CH 3 H F E1-26.16 Z26, R a  is H CH 3 F H E1-26.17 Z26, R a  is H Cl F H E1-26.18 Z26, R a  is H F F H E1-26.19 Z26, R a  is H F H F E1-26.20 Z26, R a  is H F H Cl E1-26.21 Z26, R a  is H F H CH 3 E1-26.22 Z26, R a  is H Cl H CH 3 E1-26.23 Z26, R a  is H SCH 3 H H E1-26.24 Z26, R a  is H SO 2 CH 3 H H E1-26.25 Z26, R a  is H ethynyl H H E1-27.1 Z27 H H H E1-27.2 Z27 CH 3 H H E1-27.3 Z27 Cl H H E1-27.4 Z27 F H H E1-27.5 Z27 CH 2 CH 3 H H E1-27.6 Z27 CF 2 H H H E1-27.7 Z27 CH 2 F H H E1-27.8 Z27 CF 3 H H E1-27.9 Z27 CF 2 CH 3 H H E1-27.10 Z27 CH 2 CF 3 H H E1-27.11 Z27 cyclopropyl H H E1-27.12 Z27 OCF 3 H H E1-27.13 Z27 OCF 2 H H H E1-27.14 Z27 Cl H F E1-27.15 Z27 CH 3 H F E1-27.16 Z27 CH 3 F H E1-27.17 Z27 Cl F H E1-27.18 Z27 F F H E1-27.19 Z27 F H F E1-27.20 Z27 F H Cl E1-27.21 Z27 F H CH 3 E1-27.22 Z27 Cl H CH 3 E1-27.23 Z27 SCH 3 H H E1-27.24 Z27 SO 2 CH 3 H H E1-27.25 Z27 ethynyl H H E1-28.1 Z28 H H H E1-28.2 Z28 CH 3 H H E1-28.3 Z28 Cl H H E1-28.4 Z28 F H H E1-28.5 Z28 CH 2 CH 3 H H E1-28.6 Z28 CF 2 H H H E1-28.7 Z28 CH 2 F H H E1-28.8 Z28 CF 3 H H E1-28.9 Z28 CF 2 CH 3 H H E1-28.10 Z28 CH 2 CF 3 H H E1-28.11 Z28 cyclopropyl H H E1-28.12 Z28 OCF 3 H H E1-28.13 Z28 OCF 2 H H H E1-28.14 Z28 Cl H F E1-28.15 Z28 CH 3 H F E1-28.16 Z28 CH 3 F H E1-28.17 Z28 Cl F H E1-28.18 Z28 F F H E1-28.19 Z28 F H F E1-28.20 Z28 F H Cl E1-28.21 Z28 F H CH 3 E1-28.22 Z28 Cl H CH 3 E1-28.23 Z28 SCH 3 H H E1-28.24 Z28 SO 2 CH 3 H H E1-28.25 Z28 ethynyl H H E1-29.1 Z29 H H H E1-29.2 Z29 CH 3 H H E1-29.3 Z29 Cl H H E1-29.4 Z29 F H H E1-29.5 Z29 CH 2 CH 3 H H E1-29.6 Z29 CF 2 H H H E1-29.7 Z29 CH 2 F H H E1-29.8 Z29 CF 3 H H E1-29.9 Z29 CF 2 CH 3 H H E1-29.10 Z29 CH 2 CF 3 H H E1-29.11 Z29 cyclopropyl H H E1-29.12 Z29 OCF 3 H H E1-29.13 Z29 OCF 2 H H H E1-29.14 Z29 Cl H F E1-29.15 Z29 CH 3 H F E1-29.16 Z29 CH 3 F H E1-29.17 Z29 Cl F H E1-29.18 Z29 F F H E1-29.19 Z29 F H F E1-29.20 Z29 F H Cl E1-29.21 Z29 F H CH 3 E1-29.22 Z29 Cl H CH 3 E1-29.23 Z29 SCH 3 H H E1-29.24 Z29 SO 2 CH 3 H H E1-29.25 Z29 ethynyl H H E1-30.1 Z30 H H H E1-30.2 Z30 CH 3 H H E1-30.3 Z30 Cl H H E1-30.4 Z30 F H H E1-30.5 Z30 CH 2 CH 3 H H E1-30.6 Z30 CF 2 H H H E1-30.7 Z30 CH 2 F H H E1-30.8 Z30 CF 3 H H E1-30.9 Z30 CF 2 CH 3 H H E1-30.10 Z30 CH 2 CF 3 H H E1-30.11 Z30 cyclopropyl H H E1-30.12 Z30 OCF 3 H H E1-30.13 Z30 OCF 2 H H H E1-30.14 Z30 Cl H F E1-30.15 Z30 CH 3 H F E1-30.16 Z30 CH 3 F H E1-30.17 Z30 Cl F H E1-30.18 Z30 F F H E1-30.19 Z30 F H F E1-30.20 Z30 F H Cl E1-30.21 Z30 F H CH 3 E1-30.22 Z30 Cl H CH 3 E1-30.23 Z30 SCH 3 H H E1-30.24 Z30 SO 2 CH 3 H H E1-30.25 Z30 ethynyl H H E1-31.1 Z31 H H H E1-31.2 Z31 CH 3 H H E1-31.3 Z31 Cl H H E1-31.4 Z31 F H H E1-31.5 Z31 CH 2 CH 3 H H E1-31.6 Z31 CF 2 H H H E1-31.7 Z31 CH 2 F H H E1-31.8 Z31 CF 3 H H E1-31.9 Z31 CF 2 CH 3 H H E1-31.10 Z31 CH 2 CF 3 H H E1-31.11 Z31 cyclopropyl H H E1-31.12 Z31 OCF 3 H H E1-31.13 Z31 OCF 2 H H H E1-31.14 Z31 Cl H F E1-31.15 Z31 CH 3 H F E1-31.16 Z31 CH 3 F H E1-31.17 Z31 Cl F H E1-31.18 Z31 F F H E1-31.19 Z31 F H F E1-31.20 Z31 F H Cl E1-31.21 Z31 F H CH 3 E1-31.22 Z31 Cl H CH 3 E1-31.23 Z31 SCH 3 H H E1-31.24 Z31 SO 2 CH 3 H H E1-31.25 Z31 ethynyl H H E1-32.1 Z32 H H H E1-32.2 Z32 CH 3 H H E1-32.3 Z32 Cl H H E1-32.4 Z32 F H H E1-32.5 Z32 CH 2 CH 3 H H E1-32.6 Z32 CF 2 H H H E1-32.7 Z32 CH 2 F H H E1-32.8 Z32 CF 3 H H E1-32.9 Z32 CF 2 CH 3 H H E1-32.10 Z32 CH 2 CF 3 H H E1-32.11 Z32 cyclopropyl H H E1-32.12 Z32 OCF 3 H H E1-32.13 Z32 OCF 2 H H H E1-32.14 Z32 Cl H F E1-32.15 Z32 CH 3 H F E1-32.16 Z32 CH 3 F H E1-32.17 Z32 Cl F H E1-32.18 Z32 F F H E1-32.19 Z32 F H F E1-32.20 Z32 F H Cl E1-32.21 Z32 F H CH 3 E1-32.22 Z32 Cl H CH 3 E1-32.23 Z32 SCH 3 H H E1-32.24 Z32 SO 2 CH 3 H H E1-32.25 Z32 ethynyl H H E1-33.1 Z33 H H H E1-33.2 Z33 CH 3 H H E1-33.3 Z33 Cl H H E1-33.4 Z33 F H H E1-33.5 Z33 CH 2 CH 3 H H E1-33.6 Z33 CF 2 H H H E1-33.7 Z33 CH 2 F H H E1-33.8 Z33 CF 3 H H E1-33.9 Z33 CF 2 CH 3 H H E1-33.10 Z33 CH2CF.3 H H E1-33.11 Z33 cyclopropyl H H E1-33.12 Z33 OCF 3 H H E1-33.13 Z33 OCF 2 H H H E1-33.14 Z33 Cl H F E1-33.15 Z33 CH 3 H F E1-33.16 Z33 CH 3 F H E1-33.17 Z33 Cl F H E1-33.18 Z33 F F H E1-33.19 Z33 F H F E1-33.20 Z33 F H Cl E1-33.21 Z33 F H CH 3 E1-33.22 Z33 Cl H CH 3 E1-33.23 Z33 SCH 3 H H E1-33.24 Z33 SO 2 CH 3 H H E1-33.25 Z33 ethynyl H H E1-34.1 Z34 H H H E1-34.2 Z34 CH 3 H H E1-34.3 Z34 Cl H H E1-34.4 Z34 F H H E1-34.5 Z34 CH 2 CH 3 H H E1-34.6 Z34 CF 2 H H H E1-34.7 Z34 CH 2 F H H E1-34.8 Z34 CF 3 H H E1-34.9 Z34 CF 2 CH 3 H H E1-34.10 Z34 CH 2 CF 3 H H E1-34.11 Z34 cyclopropyl H H E1-34.12 Z34 OCF 3 H H E1-34.13 Z34 OCF 2 H H H E1-34.14 Z34 Cl H F E1-34.15 Z34 CH 3 H F E1-34.16 Z34 CH 3 F H E1-34.17 Z34 Cl F H E1-34.18 Z34 F F H E1-34.19 Z34 F H F E1-34.20 Z34 F H Cl E1-34.21 Z34 F H CH 3 E1-34.22 Z34 Cl H CH 3 E1-34.23 Z34 SCH 3 H H E1-34.24 Z34 SO 2 CH 3 H H E1-34.25 Z34 ethynyl H H E1-35.1 Z35, R a  is H H H H E1-35.2 Z35, R a  is H CH 3 H H E1-35.3 Z35, R a  is H Cl H H E1-35.4 Z35, R a  is H F H H E1-35.5 Z35, R a  is H CH 2 CH 3 H H E1-35.6 Z35, R a  is H CF 2 H H H E1-35.7 Z35, R a  is H CH 2 F H H E1-35.8 Z35, R a  is H CF 3 H H E1-35.9 Z35, R a  is H CF 2 CH 3 H H E1-35.10 Z35, R a  is H CH 2 CF 3 H H E1-35.11 Z35, R a  is H cyclopropyl H H E1-35.12 Z35, R a  is H OCF 3 H H E1-35.13 Z35, R a  is H OCF 2 H H H E1-35.14 Z35, R a  is H Cl H F E1-35.15 Z35, R a  is H CH 3 H F E1-35.16 Z35, R a  is H CH 3 F H E1-35.17 Z35, R a  is H Cl F H E1-35.18 Z35, R a  is H F F H E1-35.19 Z35, R a  is H F H F E1-35.20 Z35, R a  is H F H Cl E1-35.21 Z35, R a  is H F H CH 3 E1-35.22 Z35, R a  is H Cl H CH 3 E1-35.23 Z35, R a  is H SCH 3 H H E1-35.24 Z35, R a  is H SO 2 CH 3 H H E1-35.25 Z35, R a  is H ethynyl H H E1-36.1 Z36, R a  is H H H H E1-36.2 Z36, R a  is H CH 3 H H E1-36.3 Z36, R a  is H Cl H H E1-36.4 Z36, R a  is H F H H E1-36.5 Z36, R a  is H CH 2 CH 3 H H E1-36.6 Z36, R a  is H CF 2 H H H E1-36.7 Z36, R a  is H CH 2 F H H E1-36.8 Z36, R a  is H CF 3 H H E1-36.9 Z36, R a  is H CF 2 CH 3 H H E1-36.10 Z36, R a  is H CH 2 CF 3 H H E1-36.11 Z36, R a  is H cyclopropyl H H E1-36.12 Z36, R a  is H OCF 3 H H E1-36.13 Z36, R a  is H OCF 2 H H H E1-36.14 Z36, R a  is H Cl H F E1-36.15 Z36, R a  is H CH 3 H F E1-36.16 Z36, R a  is H CH 3 F H E1-36.17 Z36, R a  is H Cl F H E1-36.18 Z36, R a  is H F F H E1-36.19 Z36, R a  is H F H F E1-36.20 Z36, R a  is H F H Cl E1-36.21 Z36, R a  is H F H CH 3 E1-36.22 Z36, R a  is H Cl H CH 3 E1-36.23 Z36, R a  is H SCH 3 H H E1-36.24 Z36, R a  is H SO 2 CH 3 H H E1-36.25 Z36, R a  is H ethynyl H H TABLE 1.E2 (S)   compound Z R 5 R 6 R 7 E2-1.1 Z1 H H H E2-1.2 Z1 CH 3 H H E2-1.3 Z1 Cl H H E2-1.4 Z1 F H H E2-1.5 Z1 CH 2 CH 3 H H E2-1.6 Z1 CF 2 H H H E2-1.7 Z1 CH 2 F H H E2-1.8 Z1 CF 3 H H E2-1.9 Z1 CF 2 CH 3 H H E2-1.10 Z1 CH 2 CF 3 H H E2-1.11 Z1 cyclopropyl H H E2-1.12 Z1 OCF 3 H H E2-1.13 Z1 OCF 2 H H H E2-1.14 Z1 Cl H F E2-1.15 Z1 CH 3 H F E2-1.16 Z1 CH 3 F H E2-1.17 Z1 Cl F H E2-1.18 Z1 F F H E2-1.19 Z1 F H F E2-1.20 Z1 F H Cl E2-1.21 Z1 F H CH 3 E2-1.22 Z1 Cl H CH 3 E2-1.23 Z1 SCH 3 H H E2-1.24 Z1 SO 2 CH 3 H H E2-1.25 Z1 ethynyl H H E2-2.1 Z2 H H H E2-2.2 Z2 CH 3 H H E2-2.3 Z2 Cl H H E2-2.4 Z2 F H H E2-2.5 Z2 CH 2 CH 3 H H E2-2.6 Z2 CF 2 H H H E2-2.7 Z2 CH 2 F H H E2-2.8 Z2 CF 3 H H E2-2.9 Z2 CF 2 CH 3 H H E2-2.10 Z2 CH 2 CF 3 H H E2-2.11 Z2 cyclopropyl H H E2-2.12 Z2 OCF 3 H H E2-2.13 Z2 OCF 2 H H H E2-2.14 Z2 Cl H F E2-2.15 Z2 CH 3 H F E2-2.16 Z2 CH 3 F H E2-2.17 Z2 Cl F H E2-2.18 Z2 F F H E2-2.19 Z2 F H F E2-2.20 Z2 F H Cl E2-2.21 Z2 F H CH 3 E2-2.22 Z2 Cl H CH 3 E2-2.23 Z2 SCH 3 H H E2-2.24 Z2 SO 2 CH 3 H H E2-2.25 Z2 ethynyl H H E2-3.1 Z3 H H H E2-3.2 Z3 CH 3 H H E2-3.3 Z3 Cl H H E2-3.4 Z3 F H H E2-3.5 Z3 CH 2 CH 3 H H E2-3.6 Z3 CF 2 H H H E2-3.7 Z3 CH 2 F H H E2-3.8 Z3 CF 3 H H E2-3.9 Z3 CF 2 CH 3 H H E2-3.10 Z3 CH 2 CF 3 H H E2-3.11 Z3 cyclopropyl H H E2-3.12 Z3 OCF 3 H H E2-3.13 Z3 OCF 2 H H H E2-3.14 Z3 Cl H F E2-3.15 Z3 CH 3 H F E2-3.16 Z3 CH 3 F H E2-3.17 Z3 Cl F H E2-3.18 Z3 F F H E2-3.19 Z3 F H F E2-3.20 Z3 F H Cl E2-3.21 Z3 F H CH 3 E2-3.22 Z3 Cl H CH 3 E2-3.23 Z3 SCH 3 H H E2-3.24 Z3 SO 2 CH 3 H H E2-3.25 Z3 ethynyl H H E2-4.1 Z4 H H H E2-4.2 Z4 CH 3 H H E2-4.3 Z4 Cl H H E2-4.4 Z4 F H H E2-4.5 Z4 CH 2 CH 3 H H E2-4.6 Z4 CF 2 H H H E2-4.7 Z4 CH 2 F H H E2-4.8 Z4 CF 3 H H E2-4.9 Z4 CF 2 CH 3 H H E2-4.10 Z4 CH 2 CF 3 H H E2-4.11 Z4 cyclopropyl H H E2-4.12 Z4 OCF 3 H H E2-4.13 Z4 OCF 2 H H H E2-4.14 Z4 Cl H F E2-4.15 Z4 CH 3 H F E2-4.16 Z4 CH 3 F H E2-4.17 Z4 Cl F H E2-4.18 Z4 F F H E2-4.19 Z4 F H F E2-4.20 Z4 F H Cl E2-4.21 Z4 F H CH 3 E2-4.22 Z4 Cl H CH 3 E2-4.23 Z4 SCH 3 H H E2-4.24 Z4 SO 2 CH 3 H H E2-4.25 Z4 ethynyl H H E2-5.1 Z5 H H H E2-5.2 Z5 CH 3 H H E2-5.3 Z5 Cl H H E2-5.4 Z5 F H H E2-5.5 Z5 CH 2 CH 3 H H E2-5.6 Z5 CF 2 H H H E2-5.7 Z5 CH 2 F H H E2-5.8 Z5 CF 3 H H E2-5.9 Z5 CF 2 CH 3 H H E2-5.10 Z5 CH 2 CF 3 H H E2-5.11 Z5 cyclopropyl H H E2-5.12 Z5 OCF 3 H H E2-5.13 Z5 OCF 2 H H H E2-5.14 Z5 Cl H F E2-5.15 Z5 CH 3 H F E2-5.16 Z5 CH 3 F H E2-5.17 Z5 Cl F H E2-5.18 Z5 F F H E2-5.19 Z5 F H F E2-5.20 Z5 F H Cl E2-5.21 Z5 F H CH 3 E2-5.22 Z5 Cl H CH 3 E2-5.23 Z5 SCH 3 H H E2-5.24 Z5 SO 2 CH 3 H H E2-5.25 Z5 ethynyl H H E2-6.1 Z6, R a  is H H H H E2-6.2 Z6, R a  is H CH 3 H H E2-6.3 Z6, R a  is H Cl H H E2-6.4 Z6, R a  is H F H H E2-6.5 Z6, R a  is H CH 2 CH 3 H H E2-6.6 Z6, R a  is H CF 2 H H H E2-6.7 Z6, R a  is H CH 2 F H H E2-6.8 Z6, R a  is H CF 3 H H E2-6.9 Z6, R a  is H CF 2 CH 3 H H E2-6.10 Z6, R a  is H CH 2 CF 3 H H E2-6.11 Z6, R a  is H cyclopropyl H H E2-6.12 Z6, R a  is H OCF 3 H H E2-6.13 Z6, R a  is H OCF 2 H H H E2-6.14 Z6, R a  is H Cl H F E2-6.15 Z6, R a  is H CH 3 H F E2-6.16 Z6, R a  is H CH 3 F H E2-6.17 Z6, R a  is H Cl F H E2-6.18 Z6, R a  is H F F H E2-6.19 Z6, R a  is H F H F E2-6.20 Z6, R a  is H F H Cl E2-6.21 Z6, R a  is H F H CH 3 E2-6.22 Z6, R a  is H Cl H CH 3 E2-6.23 Z6, R a  is H SCH 3 H H E2-6.24 Z6, R a  is H SO 2 CH 3 H H E2-6.25 Z6, R a  is H ethynyl H H E2-7.1 Z7, R a  is H H H H E2-7.2 Z7, R a  is H CH 3 H H E2-7.3 Z7, R a  is H Cl H H E2-7.4 Z7, R a  is H F H H E2-7.5 Z7, R a  is H CH 2 CH 3 H H E2-7.6 Z7, R a  is H CF 2 H H H E2-7.7 Z7, R a  is H CH 2 F H H E2-7.8 Z7, R a  is H CF 3 H H E2-7.9 Z7, R a  is H CF 2 CH 3 H H E2-7.10 Z7, R a  is H CH 2 CF 3 H H E2-7.11 Z7, R a  is H cyclopropyl H H E2-7.12 Z7, R a  is H OCF 3 H H E2-7.13 Z7, R a  is H OCF 2 H H H E2-7.14 Z7, R a  is H Cl H F E2-7.15 Z7, R a  is H CH 3 H F E2-7.16 Z7, R a  is H CH 3 F H E2-7.17 Z7, R a  is H Cl F H E2-7.18 Z7, R a  is H F F H E2-7.19 Z7, R a  is H F H F E2-7.20 Z7, R a  is H F H Cl E2-7.21 Z7, R a  is H F H CH 3 E2-7.22 Z7, R a  is H Cl H CH 3 E2-7.23 Z7, R a  is H SCH 3 H H E2-7.24 Z7, R a  is H SO 2 CH 3 H H E2-7.25 Z7, R a  is H ethynyl H H E2-8.1 Z8, R a  is H H H H E2-8.2 Z8, R a  is H CH 3 H H E2-8.3 Z8, R a  is H Cl H H E2-8.4 Z8, R a  is H F H H E2-8.5 Z8, R a  is H CH 2 CH 3 H H E2-8.6 Z8, R a  is H CF 2 H H H E2-8.7 Z8, R a  is H CH 2 F H H E2-8.8 Z8, R a  is H CF 3 H H E2-8.9 Z8, R a  is H CF 2 CH 3 H H E2-8.10 Z8, R a  is H CH 2 CF 3 H H E2-8.11 Z8, R a  is H cyclopropyl H H E2-8.12 Z8, R a  is H OCF 3 H H E2-8.13 Z8, R a  is H OCF 2 H H H E2-8.14 Z8, R a  is H Cl H F E2-8.15 Z8, R a  is H CH 3 H F E2-8.16 Z8, R a  is H CH 3 F H E2-8.17 Z8, R a  is H Cl F H E2-8.18 Z8, R a  is H F F H E2-8.19 Z8, R a  is H F H F E2-8.20 Z8, R a  is H F H Cl E2-8.21 Z8, R a  is H F H CH 3 E2-8.22 Z8, R a  is H Cl H CH 3 E2-8.23 Z8, R a  is H SCH 3 H H E2-8.24 Z8, R a  is H SO 2 CH 3 H H E2-8.25 Z8, R a  is H ethynyl H H E2-9.1 Z9 H H H E2-9.2 Z9 CH 3 H H E2-9.3 Z9 Cl H H E2-9.4 Z9 F H H E2-9.5 Z9 CH 2 CH 3 H H E2-9.6 Z9 CF 2 H H H E2-9.7 Z9 CH 2 F H H E2-9.8 Z9 CF 3 H H E2-9.9 Z9 CF 2 CH 3 H H E2-9.10 Z9 CH 2 CF 3 H H E2-9.11 Z9 cyclopropyl H H E2-9.12 Z9 OCF 3 H H E2-9.13 Z9 OCF 2 H H H E2-9.14 Z9 Cl H F E2-9.15 Z9 CH 3 H F E2-9.16 Z9 CH 3 F H E2-9.17 Z9 Cl F H E2-9.18 Z9 F F H E2-9.19 Z9 F H F E2-9.20 Z9 F H Cl E2-9.21 Z9 F H CH 3 E2-9.22 Z9 Cl H CH 3 E2-9.23 Z9 SCH 3 H H E2-9.24 Z9 SO 2 CH 3 H H E2-9.25 Z9 ethynyl H H E2-10.1 Z10 H H H E2-10.2 Z10 CH 3 H H E2-10.3 Z10 Cl H H E2-10.4 Z10 F H H E2-10.5 Z10 CH 2 CH 3 H H E2-10.6 Z10 CF 2 H H H E2-10.7 Z10 CH 2 F H H E2-10.8 Z10 CF 3 H H E2-10.9 Z10 CF 2 CH 3 H H E2-10.10 Z10 CH 2 CF 3 H H E2-10.11 Z10 cyclopropyl H H E2-10.12 Z10 OCF 3 H H E2-10.13 Z10 OCF 2 H H H E2-10.14 Z10 Cl H F E2-10.15 Z10 CH 3 H F E2-10.16 Z10 CH 3 F H E2-10.17 Z10 Cl F H E2-10.18 Z10 F F H E2-10.19 Z10 F H F E2-10.20 Z10 F H Cl E2-10.21 Z10 F H CH 3 E2-10.22 Z10 Cl H CH 3 E2-10.23 Z10 SCH 3 H H E2-10.24 Z10 SO 2 CH 3 H H E2-10.25 Z10 ethynyl H H E2-11.1 Z11, R a  is H H H H E2-11.2 Z11, R a  is H CH 3 H H E2-11.3 Z11, R a  is H Cl H H E2-11.4 Z11, R a  is H F H H E2-11.5 Z11, R a  is H CH 2 CH 3 H H E2-11.6 Z11, R a  is H CF 2 H H H E2-11.7 Z11, R a  is H CH 2 F H H E2-11.8 Z11, R a  is H CF 3 H H E2-11.9 Z11, R a  is H CF 2 CH 3 H H E2-11.10 Z11, R a  is H CH 2 CF 3 H H E2-11.11 Z11, R a  is H cyclopropyl H H E2-11.12 Z11, R a  is H OCF 3 H H E2-11.13 Z11, R a  is H OCF 2 H H H E2-11.14 Z11, R a  is H Cl H F E2-11.15 Z11, R a  is H CH 3 H F E2-11.16 Z11, R a  is H CH 3 F H E2-11.17 Z11, R a  is H Cl F H E2-11.18 Z11, R a  is H F F H E2-11.19 Z11, R a  is H F H F E2-11.20 Z11, R a  is H F H Cl E2-11.21 Z11, R a  is H F H CH 3 E2-11.22 Z11, R a  is H Cl H CH 3 E2-11.23 Z11, R a  is H SCH 3 H H E2-11.24 Z11, R a  is H SO 2 CH 3 H H E2-11.25 Z11, R a  is H ethynyl H H E2-12.1 Z12 H H H E2-12.2 Z12 CH 3 H H E2-12.3 Z12 Cl H H E2-12.4 Z12 F H H E2-12.5 Z12 CH 2 CH 3 H H E2-12.6 Z12 CF 2 H H H E2-12.7 Z12 CH 2 F H H E2-12.8 Z12 CF 3 H H E2-12.9 Z12 CF 2 CH 3 H H E2-12.10 Z12 CH 2 CF 3 H H E2-12.11 Z12 cyclopropyl H H E2-12.12 Z12 OCF 3 H H E2-12.13 Z12 OCF 2 H H H E2-12.14 Z12 Cl H F E2-12.15 Z12 CH 3 H F E2-12.16 Z12 CH 3 F H E2-12.17 Z12 Cl F H E2-12.18 Z12 F F H E2-12.19 Z12 F H F E2-12.20 Z12 F H Cl E2-12.21 Z12 F H CH 3 E2-12.22 Z12 Cl H CH 3 E2-12.23 Z12 SCH 3 H H E2-12.24 Z12 SO 2 CH 3 H H E2-12.25 Z12 ethynyl H H E2-13.1 Z13, R a  is H H H H E2-13.2 Z13, R a  is H CH 3 H H E2-13.3 Z13, R a  is H Cl H H E2-13.4 Z13, R a  is H F H H E2-13.5 Z13, R a  is H CH 2 CH 3 H H E2-13.6 Z13, R a  is H CF 2 H H H E2-13.7 Z13, R a  is H CH 2 F H H E2-13.8 Z13, R a  is H CF 3 H H E2-13.9 Z13, R a  is H CF 2 CH 3 H H E2-13.10 Z13, R a  is H CH 2 CF 3 H H E2-13.11 Z13, R a  is H cyclopropyl H H E2-13.12 Z13, R a  is H OCF 3 H H E2-13.13 Z13, R a  is H OCF 2 H H H E2-13.14 Z13, R a  is H Cl H F E2-13.15 Z13, R a  is H CH 3 H F E2-13.16 Z13, R a  is H CH 3 F H E2-13.17 Z13, R a  is H Cl F H E2-13.18 Z13, R a  is H F F H E2-13.19 Z13, R a  is H F H F E2-13.20 Z13, R a  is H F H Cl E2-13.21 Z13, R a  is H F H CH 3 E2-13.22 Z13, R a  is H Cl H CH 3 E2-13.23 Z13, R a  is H SCH 3 H H E2-13.24 Z13, R a  is H SO 2 CH 3 H H E2-13.25 Z13, R a  is H ethynyl H H E2-14.1 Z14, R a  is H H H H E2-14.2 Z14, R a  is H CH 3 H H E2-14.3 Z14, R a  is H Cl H H E2-14.4 Z14, R a  is H F H H E2-14.5 Z14, R a  is H CH 2 CH 3 H H E2-14.6 Z14, R a  is H CF 2 H H H E2-14.7 Z14, R a  is H CH 2 F H H E2-14.8 Z14, R a  is H CF 3 H H E2-14.9 Z14, R a  is H CF 2 CH 3 H H E2-14.10 Z14, R a  is H CH 2 CF 3 H H E2-14.11 Z14, R a  is H cyclopropyl H H E2-14.12 Z14, R a  is H OCF 3 H H E2-14.13 Z14, R a  is H OCF 2 H H H E2-14.14 Z14, R a  is H Cl H F E2-14.15 Z14, R a  is H CH 3 H F E2-14.16 Z14, R a  is H CH 3 F H E2-14.17 Z14, R a  is H Cl F H E2-14.18 Z14, R a  is H F F H E2-14.19 Z14, R a  is H F H F E2-14.20 Z14, R a  is H F H Cl E2-14.21 Z14, R a  is H F H CH 3 E2-14.22 Z14, R a  is H Cl H CH 3 E2-14.23 Z14, R a  is H SCH 3 H H E2-14.24 Z14, R a  is H SO 2 CH 3 H H E2-14.25 Z14, R a  is H ethynyl H H E2-15.1 Z15, R a  is H H H H E2-15.2 Z15, R a  is H CH 3 H H E2-15.3 Z15, R a  is H Cl H H E2-15.4 Z15, R a  is H F H H E2-15.5 Z15, R a  is H CH 2 CH 3 H H E2-15.6 Z15, R a  is H CF 2 H H H E2-15.7 Z15, R a  is H CH 2 F H H E2-15.8 Z15, R a  is H CF 3 H H E2-15.9 Z15, R a  is H CF 2 CH 3 H H E2-15.10 Z15, R a  is H CH 2 CF 3 H H E2-15.11 Z15, R a  is H cyclopropyl H H E2-15.12 Z15, R a  is H OCF 3 H H E2-15.13 Z15, R a  is H OCF 2 H H H E2-15.14 Z15, R a  is H Cl H F E2-15.15 Z15, R a  is H CH 3 H F E2-15.16 Z15, R a  is H CH 3 F H E2-15.17 Z15, R a  is H Cl F H E2-15.18 Z15, R a  is H F F H E2-15.19 Z15, R a  is H F H F E2-15.20 Z15, R a  is H F H Cl E2-15.21 Z15, R a  is H F H CH 3 E2-15.22 Z15, R a  is H Cl H CH 3 E2-15.23 Z15, R a  is H SCH 3 H H E2-15.24 Z15, R a  is H SO 2 CH 3 H H E2-15.25 Z15, R a  is H ethynyl H H E2-16.1 Z16, R a  is H H H H E2-16.2 Z16, R a  is H CH 3 H H E2-16.3 Z16, R a  is H Cl H H E2-16.4 Z16, R a  is H F H H E2-16.5 Z16, R a  is H CH 2 CH 3 H H E2-16.6 Z16, R a  is H CF 2 H H H E2-16.7 Z16, R a  is H CH 2 F H H E2-16.8 Z16, R a  is H CF 3 H H E2-16.9 Z16, R a  is H CF 2 CH 3 H H E2-16.10 Z16, R a  is H CH 2 CF 3 H H E2-16.11 Z16, R a  is H cyclopropyl H H E2-16.12 Z16, R a  is H OCF 3 H H E2-16.13 Z16, R a  is H OCF 2 H H H E2-16.14 Z16, R a  is H Cl H F E2-16.15 Z16, R a  is H CH 3 H F E2-16.16 Z16, R a  is H CH 3 F H E2-16.17 Z16, R a  is H Cl F H E2-16.18 Z16, R a  is H F F H E2-16.19 Z16, R a  is H F H F E2-16.20 Z16, R a  is H F H Cl E2-16.21 Z16, R a  is H F H CH 3 E2-16.22 Z16, R a  is H Cl H CH 3 E2-16.23 Z16, R a  is H SCH 3 H H E2-16.24 Z16, R a  is H SO 2 CH 3 H H E2-16.25 Z16, R a  is H ethynyl H H E2-17.1 Z17 H H H E2-17.2 Z17 CH 3 H H E2-17.3 Z17 Cl H H E2-17.4 Z17 F H H E2-17.5 Z17 CH 2 CH 3 H H E2-17.6 Z17 CF 2 H H H E2-17.7 Z17 CH 2 F H H E2-17.8 Z17 CF 3 H H E2-17.9 Z17 CF 2 CH 3 H H E2-17.10 Z17 CH 2 CF 3 H H E2-17.11 Z17 cyclopropyl H H E2-17.12 Z17 OCF 3 H H E2-17.13 Z17 OCF 2 H H H E2-17.14 Z17 Cl H F E2-17.15 Z17 CH 3 H F E2-17.16 Z17 CH 3 F H E2-17.17 Z17 Cl F H E2-17.18 Z17 F F H E2-17.19 Z17 F H F E2-17.20 Z17 F H Cl E2-17.21 Z17 F H CH 3 E2-17.22 Z17 Cl H CH 3 E2-17.23 Z17 SCH 3 H H E2-17.24 Z17 SO 2 CH 3 H H E2-17.25 Z17 ethynyl H H E2-18.1 Z18 H H H E2-18.2 Z18 CH 3 H H E2-18.3 Z18 Cl H H E2-18.4 Z18 F H H E2-18.5 Z18 CH 2 CH 3 H H E2-18.6 Z18 CF 2 H H H E2-18.7 Z18 CH 2 F H H E2-18.8 Z18 CF 3 H H E2-18.9 Z18 CF 2 CH 3 H H E2-18.10 Z18 CH 2 CF 3 H H E2-18.11 Z18 cyclopropyl H H E2-18.12 Z18 OCF 3 H H E2-18.13 Z18 OCF 2 H H H E2-18.14 Z18 Cl H F E2-18.15 Z18 CH 3 H F E2-18.16 Z18 CH 3 F H E2-18.17 Z18 Cl F H E2-18.18 Z18 F F H E2-18.19 Z18 F H F E2-18.20 Z18 F H Cl E2-18.21 Z18 F H CH 3 E2-18.22 Z18 Cl H CH 3 E2-18.23 Z18 SCH 3 H H E2-18.24 Z18 SO 2 CH 3 H H E2-18.25 Z18 ethynyl H H E2-19.1 Z19 H H H E2-19.2 Z19 CH 3 H H E2-19.3 Z19 Cl H H E2-19.4 Z19 F H H E2-19.5 Z19 CH 2 CH 3 H H E2-19.6 Z19 CF 2 H H H E2-19.7 Z19 CH 2 F H H E2-19.8 Z19 CF 3 H H E2-19.9 Z19 CF 2 CH 3 H H E2-19.10 Z19 CH 2 CF 3 H H E2-19.11 Z19 cyclopropyl H H E2-19.12 Z19 OCF 3 H H E2-19.13 Z19 OCF 2 H H H E2-19.14 Z19 Cl H F E2-19.15 Z19 CH 3 H F E2-19.16 Z19 CH 3 F H E2-19.17 Z19 Cl F H E2-19.18 Z19 F F H E2-19.19 Z19 F H F E2-19.20 Z19 F H Cl E2-19.21 Z19 F H CH 3 E2-19.22 Z19 Cl H CH 3 E2-19.23 Z19 SCH 3 H H E2-19.24 Z19 SO 2 CH 3 H H E2-19.25 Z19 ethynyl H H E2-19.26 Z19 CH 3 H H E2-20.1 Z20 H H H E2-20.2 Z20 CH 3 H H E2-20.3 Z20 Cl H H E2-20.4 Z20 F H H E2-20.5 Z20 CH 2 CH 3 H H E2-20.6 Z20 CF 2 H H H E2-20.7 Z20 CH 2 F H H E2-20.8 Z20 CF 3 H H E2-20.9 Z20 CF 2 CH 3 H H E2-20.10 Z20 CH 2 CF 3 H H E2-20.11 Z20 cyclopropyl H H E2-20.12 Z20 OCF 3 H H E2-20.13 Z20 OCF 2 H H H E2-20.14 Z20 Cl H F E2-20.15 Z20 CH 3 H F E2-20.16 Z20 CH 3 F H E2-20.17 Z20 Cl F H E2-20.18 Z20 F F H E2-20.19 Z20 F H F E2-20.20 Z20 F H Cl E2-20.21 Z20 F H CH 3 E2-20.22 Z20 Cl H CH 3 E2-20.23 Z20 SCH 3 H H E2-20.24 Z20 SO 2 CH 3 H H E2-20.25 Z20 ethynyl H H E2-21.1 Z21 H H H E2-21.2 Z21 CH 3 H H E2-21.3 Z21 Cl H H E2-21.4 Z21 F H H E2-21.5 Z21 CH 2 CH 3 H H E2-21.6 Z21 CF 2 H H H E2-21.7 Z21 CH 2 F H H E2-21.8 Z21 CF 3 H H E2-21.9 Z21 CF 2 CH 3 H H E2-21.10 Z21 CH 2 CF 3 H H E2-21.11 Z21 cyclopropyl H H E2-21.12 Z21 OCF 3 H H E2-21.13 Z21 OCF 2 H H H E2-21.14 Z21 Cl H F E2-21.15 Z21 CH 3 H F E2-21.16 Z21 CH 3 F H E2-21.17 Z21 Cl F H E2-21.18 Z21 F F H E2-21.19 Z21 F H F E2-21.20 Z21 F H Cl E2-21.21 Z21 F H CH 3 E2-21.22 Z21 Cl H CH 3 E2-21.23 Z21 SCH 3 H H E2-21.24 Z21 SO 2 CH 3 H H E2-21.25 Z21 ethynyl H H   E2-21.26 \n \u2003 R x  is CH 3 CH 3 H H   E2-22.1 Z22 H H H E2-22.2 Z22 CH 3 H H E2-22.3 Z22 Cl H H E2-22.4 Z22 F H H E2-22.5 Z22 CH 2 CH 3 H H E2-22.6 Z22 CF 2 H H H E2-22.7 Z22 CH 2 F H H E2-22.8 Z22 CF 3 H H E2-22.9 Z22 CF 2 CH 3 H H E2-22.10 Z22 CH 2 CF 3 H H E2-22.11 Z22 cyclopropyl H H E2-22.12 Z22 OCF 3 H H E2-22.13 Z22 OCF 2 H H H E2-22.14 Z22 Cl H F E2-22.15 Z22 CH 3 H F E2-22.16 Z22 CH 3 F H E2-22.17 Z22 Cl F H E2-22.18 Z22 F F H E2-22.19 Z22 F H F E2-22.20 Z22 F H Cl E2-22.21 Z22 F H CH 3 E2-22.22 Z22 Cl H CH 3 E2-22.23 Z22 SCH 3 H H E2-22.24 Z22 SO 2 CH 3 H H E2-22.25 Z22 ethynyl H H E2-23.1 Z23 H H H E2-23.2 Z23 CH 3 H H E2-23.3 Z23 Cl H H E2-23.4 Z23 F H H E2-23.5 Z23 CH 2 CH 3 H H E2-23.6 Z23 CF 2 H H H E2-23.7 Z23 CH 2 F H H E2-23.8 Z23 CF 3 H H E2-23.9 Z23 CF 2 CH 3 H H E2-23.10 Z23 CH 2 CF 3 H H E2-23.11 Z23 cyclopropyl H H E2-23.12 Z23 OCF 3 H H E2-23.13 Z23 OCF 2 H H H E2-23.14 Z23 Cl H F E2-23.15 Z23 CH 3 H F E2-23.16 Z23 CH 3 F H E2-23.17 Z23 Cl F H E2-23.18 Z23 F F H E2-23.19 Z23 F H F E2-23.20 Z23 F H Cl E2-23.21 Z23 F H CH 3 E2-23.22 Z23 Cl H CH 3 E2-23.23 Z23 SCH 3 H H E2-23.24 Z23 SO 2 CH 3 H H E2-23.25 Z23 ethynyl H H E2-24.1 Z24 H H H E2-24.2 Z24 CH 3 H H E2-24.3 Z24 Cl H H E2-24.4 Z24 F H H E2-24.5 Z24 CH 2 CH 3 H H E2-24.6 Z24 CF 2 H H H E2-24.7 Z24 CH 2 F H H E2-24.8 Z24 CF 3 H H E2-24.9 Z24 CF 2 CH 3 H H E2-24.10 Z24 CH 2 CF 3 H H E2-24.11 Z24 cyclopropyl H H E2-24.12 Z24 OCF 3 H H E2-24.13 Z24 OCF 2 H H H E2-24.14 Z24 Cl H F E2-24.15 Z24 CH 3 H F E2-24.16 Z24 CH 3 F H E2-24.17 Z24 Cl F H E2-24.18 Z24 F F H E2-24.19 Z24 F H F E2-24.20 Z24 F H Cl E2-24.21 Z24 F H CH 3 E2-24.22 Z24 Cl H CH 3 E2-24.23 Z24 SCH 3 H H E2-24.24 Z24 SO 2 CH 3 H H E2-24.25 Z24 ethynyl H H E2-25.1 Z25, R a  is H H H H E2-25.2 Z25, R a  is H CH 3 H H E2-25.3 Z25, R a  is H Cl H H E2-25.4 Z25, R a  is H F H H E2-25.5 Z25, R a  is H CH 2 CH 3 H H E2-25.6 Z25, R a  is H CF 2 H H H E2-25.7 Z25, R a  is H CH 2 F H H E2-25.8 Z25, R a  is H CF 3 H H E2-25.9 Z25, R a  is H CF 2 CH 3 H H E2-25.10 Z25, R a  is H CH 2 CF 3 H H E2-25.11 Z25, R a  is H cyclopropyl H H E2-25.12 Z25, R a  is H OCF 3 H H E2-25.13 Z25, R a  is H OCF 2 H H H E2-25.14 Z25, R a  is H Cl H F E2-25.15 Z25, R a  is H CH 3 H F E2-25.16 Z25, R a  is H CH 3 F H E2-25.17 Z25, R a  is H Cl F H E2-25.18 Z25, R a  is H F F H E2-25.19 Z25, R a  is H F H F E2-25.20 Z25, R a  is H F H Cl E2-25.21 Z25, R a  is H F H CH 3 E2-25.22 Z25, R a  is H Cl H CH 3 E2-25.23 Z25, R a  is H SCH 3 H H E2-25.24 Z25, R a  is H SO 2 CH 3 H H E2-25.25 Z25, R a  is H ethynyl H H E2-26.1 Z26, R a  is H H H H E2-26.2 Z26, R a  is H CH 3 H H E2-26.3 Z26, R a  is H Cl H H E2-26.4 Z26, R a  is H F H H E2-26.5 Z26, R a  is H CH 2 CH 3 H H E2-26.6 Z26, R a  is H CF 2 H H H E2-26.7 Z26, R a  is H CH 2 F H H E2-26.8 Z26, R a  is H CF 3 H H E2-26.9 Z26, R a  is H CF 2 CH 3 H H E2-26.10 Z26, R a  is H CH 2 CF 3 H H E2-26.11 Z26, R a  is H cyclopropyl H H E2-26.12 Z26, R a  is H OCF 3 H H E2-26.13 Z26, R a  is H OCF 2 H H H E2-26.14 Z26, R a  is H Cl H F E2-26.15 Z26, R a  is H CH 3 H F E2-26.16 Z26, R a  is H CH 3 F H E2-26.17 Z26, R a  is H Cl F H E2-26.18 Z26, R a  is H F F H E2-26.19 Z26, R a  is H F H F E2-26.20 Z26, R a  is H F H Cl E2-26.21 Z26, R a  is H F H CH 3 E2-26.22 Z26, R a  is H Cl H CH 3 E2-26.23 Z26, R a  is H SCH 3 H H E2-26.24 Z26, R a  is H SO 2 CH 3 H H E2-26.25 Z26, R a  is H ethynyl H H E2-27.1 Z27 H H H E2-27.2 Z27 CH 3 H H E2-27.3 Z27 Cl H H E2-27.4 Z27 F H H E2-27.5 Z27 CH 2 CH 3 H H E2-27.6 Z27 CF 2 H H H E2-27.7 Z27 CH 2 F H H E2-27.8 Z27 CF 3 H H E2-27.9 Z27 CF 2 CH 3 H H E2-27.10 Z27 CH 2 CF 3 H H E2-27.11 Z27 cyclopropyl H H E2-27.12 Z27 OCF 3 H H E2-27.13 Z27 OCF 2 H H H E2-27.14 Z27 Cl H F E2-27.15 Z27 CH 3 H F E2-27.16 Z27 CH 3 F H E2-27.17 Z27 Cl F H E2-27.18 Z27 F F H E2-27.19 Z27 F H F E2-27.20 Z27 F H Cl E2-27.21 Z27 F H CH 3 E2-27.22 Z27 Cl H CH 3 E2-27.23 Z27 SCH 3 H H E2-27.24 Z27 SO 2 CH 3 H H E2-27.25 Z27 ethynyl H H E2-28.1 Z28 H H H E2-28.2 Z28 CH 3 H H E2-28.3 Z28 Cl H H E2-28.4 Z28 F H H E2-28.5 Z28 CH 2 CH 3 H H E2-28.6 Z28 CF 2 H H H E2-28.7 Z28 CH 2 F H H E2-28.8 Z28 CF 3 H H E2-28.9 Z28 CF 2 CH 3 H H E2-28.10 Z28 CH 2 CF 3 H H E2-28.11 Z28 cyclopropyl H H E2-28.12 Z28 OCF 3 H H E2-28.13 Z28 OCF 2 H H H E2-28.14 Z28 Cl H F E2-28.15 Z28 CH 3 H F E2-28.16 Z28 CH 3 F H E2-28.17 Z28 Cl F H E2-28.18 Z28 F F H E2-28.19 Z28 F H F E2-28.20 Z28 F H Cl E2-28.21 Z28 F H CH 3 E2-28.22 Z28 Cl H CH 3 E2-28.23 Z28 SCH 3 H H E2-28.24 Z28 SO 2 CH 3 H H E2-28.25 Z28 ethynyl H H E2-29.1 Z29 H H H E2-29.2 Z29 CH 3 H H E2-29.3 Z29 Cl H H E2-29.4 Z29 F H H E2-29.5 Z29 CH 2 CH 3 H H E2-29.6 Z29 CF 2 H H H E2-29.7 Z29 CH 2 F H H E2-29.8 Z29 CF 3 H H E2-29.9 Z29 CF 2 CH 3 H H E2-29.10 Z29 CH 2 CF 3 H H E2-29.11 Z29 cyclopropyl H H E2-29.12 Z29 OCF 3 H H E2-29.13 Z29 OCF 2 H H H E2-29.14 Z29 Cl H F E2-29.15 Z29 CH 3 H F E2-29.16 Z29 CH 3 F H E2-29.17 Z29 Cl F H E2-29.18 Z29 F F H E2-29.19 Z29 F H F E2-29.20 Z29 F H Cl E2-29.21 Z29 F H CH 3 E2-29.22 Z29 Cl H CH 3 E2-29.23 Z29 SCH 3 H H E2-29.24 Z29 SO 2 CH 3 H H E2-29.25 Z29 ethynyl H H E2-30.1 Z30 H H H E2-30.2 Z30 CH 3 H H E2-30.3 Z30 Cl H H E2-30.4 Z30 F H H E2-30.5 Z30 CH 2 CH 3 H H E2-30.6 Z30 CF 2 H H H E2-30.7 Z30 CH 2 F H H E2-30.8 Z30 CF 3 H H E2-30.9 Z30 CF 2 CH 3 H H E2-30.10 Z30 CH 2 CF 3 H H E2-30.11 Z30 cyclopropyl H H E2-30.12 Z30 OCF 3 H H E2-30.13 Z30 OCF 2 H H H E2-30.14 Z30 Cl H F E2-30.15 Z30 CH 3 H F E2-30.16 Z30 CH 3 F H E2-30.17 Z30 Cl F H E2-30.18 Z30 F F H E2-30.19 Z30 F H F E2-30.20 Z30 F H Cl E2-30.21 Z30 F H CH 3 E2-30.22 Z30 Cl H CH 3 E2-30.23 Z30 SCH 3 H H E2-30.24 Z30 SO 2 CH 3 H H E2-30.25 Z30 ethynyl H H E2-31.1 Z31 H H H E2-31.2 Z31 CH 3 H H E2-31.3 Z31 Cl H H E2-31.4 Z31 F H H E2-31.5 Z31 CH 2 CH 3 H H E2-31.6 Z31 CF 2 H H H E2-31.7 Z31 CH 2 F H H E2-31.8 Z31 CF 3 H H E2-31.9 Z31 CF 2 CH 3 H H E2-31.10 Z31 CH 2 CF 3 H H E2-31.11 Z31 cyclopropyl H H E2-31.12 Z31 OCF 3 H H E2-31.13 Z31 OCF 2 H H H E2-31.14 Z31 Cl H F E2-31.15 Z31 CH 3 H F E2-31.16 Z31 CH 3 F H E2-31.17 Z31 Cl F H E2-31.18 Z31 F F H E2-31.19 Z31 F H F E2-31.20 Z31 F H Cl E2-31.21 Z31 F H CH 3 E2-31.22 Z31 Cl H CH 3 E2-31.23 Z31 SCH 3 H H E2-31.24 Z31 SO 2 CH 3 H H E2-31.25 Z31 ethynyl H H E2-32.1 Z32 H H H E2-32.2 Z32 CH 3 H H E2-32.3 Z32 Cl H H E2-32.4 Z32 F H H E2-32.5 Z32 CH 2 CH 3 H H E2-32.6 Z32 CF 2 H H H E2-32.7 Z32 CH 2 F H H E2-32.8 Z32 CF 3 H H E2-32.9 Z32 CF 2 CH 3 H H E2-32.10 Z32 CH 2 CF 3 H H E2-32.11 Z32 cyclopropyl H H E2-32.12 Z32 OCF 3 H H E2-32.13 Z32 OCF 2 H H H E2-32.14 Z32 Cl H F E2-32.15 Z32 CH 3 H F E2-32.16 Z32 CH 3 F H E2-32.17 Z32 Cl F H E2-32.18 Z32 F F H E2-32.19 Z32 F H F E2-32.20 Z32 F H Cl E2-32.21 Z32 F H CH 3 E2-32.22 Z32 Cl H CH 3 E2-32.23 Z32 SCH 3 H H E2-32.24 Z32 SO 2 CH 3 H H E2-32.25 Z32 ethynyl H H E2-33.1 Z33 H H H E2-33.2 Z33 CH 3 H H E2-33.3 Z33 Cl H H E2-33.4 Z33 F H H E2-33.5 Z33 CH 2 CH 3 H H E2-33.6 Z33 CF 2 H H H E2-33.7 Z33 CH 2 F H H E2-33.8 Z33 CF 3 H H E2-33.9 Z33 CF 2 CH 3 H H E2-33.10 Z33 CH 2 CF 3 H H E2-33.11 Z33 cyclopropyl H H E2-33.12 Z33 OCF 3 H H E2-33.13 Z33 OCF 2 H H H E2-33.14 Z33 Cl H F E2-33.15 Z33 CH 3 H F E2-33.16 Z33 CH 3 F H E2-33.17 Z33 Cl F H E2-33.18 Z33 F F H E2-33.19 Z33 F H F E2-33.20 Z33 F H Cl E2-33.21 Z33 F H CH 3 E2-33.22 Z33 Cl H CH 3 E2-33.23 Z33 SCH 3 H H E2-33.24 Z33 SO 2 CH 3 H H E2-33.25 Z33 ethynyl H H E2-34.1 Z34 H H H E2-34.2 Z34 CH 3 H H E2-34.3 Z34 Cl H H E2-34.4 Z34 F H H E2-34.5 Z34 CH 2 CH 3 H H E2-34.6 Z34 CF 2 H H H E2-34.7 Z34 CH 2 F H H E2-34.8 Z34 CF 3 H H E2-34.9 Z34 CF 2 CH 3 H H E2-34.10 Z34 CH 2 CF 3 H H E2-34.11 Z34 cyclopropyl H H E2-34.12 Z34 OCF 3 H H E2-34.13 Z34 OCF 2 H H H E2-34.14 Z34 Cl H F E2-34.15 Z34 CH 3 H F E2-34.16 Z34 CH 3 F H E2-34.17 Z34 Cl F H E2-34.18 Z34 F F H E2-34.19 Z34 F H F E2-34.20 Z34 F H Cl E2-34.21 Z34 F H CH 3 E2-34.22 Z34 Cl H CH 3 E2-34.23 Z34 SCH 3 H H E2-34.24 Z34 SO 2 CH 3 H H E2-34.25 Z34 ethynyl H H E2-35.1 Z35, R a  is H H H H E2-35.2 Z35, R a  is H CH 3 H H E2-35.3 Z35, R a  is H Cl H H E2-35.4 Z35, R a  is H F H H E2-35.5 Z35, R a  is H CH 2 CH 3 H H E2-35.6 Z35, R a  is H CF 2 H H H E2-35.7 Z35, R a  is H CH 2 F H H E2-35.8 Z35, R a  is H CF 3 H H E2-35.9 Z35, R a  is H CF 2 CH 3 H H E2-35.10 Z35, R a  is H CH 2 CF 3 H H E2-35.11 Z35, R a  is H cyclopropyl H H E2-35.12 Z35, R a  is H OCF 3 H H E2-35.13 Z35, R a  is H OCF 2 H H H E2-35.14 Z35, R a  is H Cl H F E2-35.15 Z35, R a  is H CH 3 H F E2-35.16 Z35, R a  is H CH 3 F H E2-35.17 Z35, R a  is H Cl F H E2-35.18 Z35, R a  is H F F H E2-35.19 Z35, R a  is H F H F E2-35.20 Z35, R a  is H F H Cl E2-35.21 Z35, R a  is H F H CH 3 E2-35.22 Z35, R a  is H Cl H CH 3 E2-35.23 Z35, R a  is H SCH 3 H H E2-35.24 Z35, R a  is H SO 2 CH 3 H H E2-35.25 Z35, R a  is H ethynyl H H E2-36.1 Z36, R a  is H H H H E2-36.2 Z36, R a  is H CH 3 H H E2-36.3 Z36, R a  is H Cl H H E2-36.4 Z36, R a  is H F H H E2-36.5 Z36, R a  is H CH 2 CH 3 H H E2-36.6 Z36, R a  is H CF 2 H H H E2-36.7 Z36, R a  is H CH 2 F H H E2-36.8 Z36, R a  is H CF 3 H H E2-36.9 Z36, R a  is H CF 2 CH 3 H H E2-36.10 Z36, R a  is H CH 2 CF 3 H H E2-36.11 Z36, R a  is H cyclopropyl H H E2-36.12 Z36, R a  is H OCF 3 H H E2-36.13 Z36, R a  is H OCF 2 H H H E2-36.14 Z36, R a  is H Cl H F E2-36.15 Z36, R a  is H CH 3 H F E2-36.16 Z36, R a  is H CH 3 F H E2-36.17 Z36, R a  is H Cl F H E2-36.18 Z36, R a  is H F F H E2-36.19 Z36, R a  is H F H F E2-36.20 Z36, R a  is H F H Cl E2-36.21 Z36, R a  is H F H CH 3 E2-36.22 Z36, R a  is H Cl H CH 3 E2-36.23 Z36, R a  is H SCH 3 H H E2-36.24 Z36, R a  is H SO 2 CH 3 H H E2-36.25 Z36, R a  is H ethynyl H H

Metadata:
- Claim Count in Document: 24.0
- Percentile: 96.0
- Lexical Diversity: 1.65957
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15578460', '13820304', '14452729', '15548594', '15961553']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7831058516598236
- 35 USC 102 Novelty (BERT): 0.62121748564177
- Combined Prediction Score: 0.7669170150580182
- Mean Citation Score: 395.618496
- Max Citation Score: 596.97144
- Similarity Product: 508.0386784266472

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test