PATENT CLAIM ANALYSIS

Application Number: 15890040
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "183000"]

Abstract:
The present invention relates to chimeric (including bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including metastatic cancer where cancer cells exhibit overexpression (heightened expression) of cell surface urokinase-type plasminogen activator receptor (urokinase receptor) compared to normal (non-cancerous) cells. The compounds bind to the urokinase-type plasminogen activator receptor (uPAR) on the surface of a cancer cell, including a metastatic cancer cell, and consequently recruit native antibodies of the patient or subject where the antibodies can selectively degrade and/or deactivate targeted cancer cells through antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) against a large number and variety of cancers, thus providing cancer cell death and an inhibition of growth, elaboration and/or metastasis of the cancer, including remission and cure of the patient's cancer.

Claim (Index 18):
The compound according to  claim 2  wherein said A B M group is a group according to the chemical structure: Where X R  is O, S or NR 1 ; and X M  is O, NR 1  or S, and R 1  is H or a C 1 -C 3  alkyl group.

Metadata:
- Claim Count in Document: 104.0
- Percentile: 88.0
- Lexical Diversity: 1.93976
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14397995', '15374272', '13173480', '14480204', '12991926']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8116287119394907
- 35 USC 102 Novelty (BERT): 0.5196008705460153
- Combined Prediction Score: 0.7824259278001432
- Mean Citation Score: 313.007338
- Max Citation Score: 320.29672
- Similarity Product: 243.44465259114745

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test