PATENT CLAIM ANALYSIS

Application Number: 15865963
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "094000"]

Abstract:
The present invention discloses compounds according to Formula I: wherein R 1  is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.

Claim (Index 13):
A method according to  claim 1 , wherein the compound is selected from:\n 2-(2-fluorobenzamido)-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-1H-pyrazole-5-carboxamide, 2-(2-hydroxybenzamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(1-hydroxycyclopropanecarboxamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 5,5,7,7-tetramethy1-2-(2-(trifluoromethy1)benzamido)-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(2-hydroxy-2-methy1propanamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(4-fluoro-2-(trifluoromethyl)benzamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(2,4-difluorobenzamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(1-(hydroxymethyl)cyclopropanecarboxamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(3-hydroxy-2,2-dimethy 1propanamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-5-methy1-1H-pyrazole-3-carboxamide, methy 1 1-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-ylcarbamoy1)-cyclopropanecarboxylate, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-5-cyclopropy1-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-5-isopropy1-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide, 5-tert-butyl-N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-5-ethyl-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-1H-1,2,4-triazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-3-ethyl-4-methyl-1H-pyrazole-5-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-2-fluoronicotinamide, 2-(4-fluoro-2-hydroxybenzamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(2-hydroxypropanamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-2-oxo-1,2-dihydropyridine-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-6-fluoropicolinamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-4-chloro-1H-pyrazole-3-carboxamide, 2-(2-(1H-1,2,4-triazol-5-y)benzamido)-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(2-(1H-imidazol-2-y)benzamido)-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 5,5,7,7-tetramethy1-2-(2-(methylsulfonamido)benzamido)-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-5-oxopyrrolidine-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-2-oxopyrrolidine-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxamide, 4-bromo-N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-4-chloro-5-methyl-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-4-methyl-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-4-chloro-5-ethyl-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-4,6-dihydro-1H-furo[3,4-c]pyrazole-3-carboxamide, 2-(2-hydroxy-3,3-dimethylbutanamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(2-hydroxy-3-methylbutanamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(1-(hydroxymethy1)cyclobutanecarboxamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide, 4-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-ylcarbamoy1)tetrahydro-2H-pyran-4-y1 acetate, N-(3-carbamoy1-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y1)-5-(methoxymethyl)-1H-pyrazole-3-carboxamide, Cis-2 [[2-fluorocyclopropanecarbonyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, Enantiomer 1, Cis-2 [[2-fluorocyclopropanecarbonyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, Enantiomer 2, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(3,6-dihydro-2H-pyran-4-y1)-1H-pyrazole-3-carboxamide, 2-[(2-hydroxy-4-methy1-pentanoyl)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(3,3-difluorocyclobutanecarbony1)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(2,2-difluorocyclopropanecarbony1)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-1H-pyrazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-chloro-5-(methoxymethyl)-1H-pyrazole-3-carboxamide, 2-[[2-hydroxy-3-methyl-butanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, Enantiomer 1, 2-[[2-hydroxy-3-methyl-butanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, Enantiomer 2, 2-(2-hydroxybutanoylamino)-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, 5-Ethoxy-1H-pyrazole-3-carboxylic acid (3-carbamoyl-5,5,7,7-tetramethy1-4,7-dihydro-5H-thieno[2,3-c]pyran-2-y1)-amide, 5-(2-Methoxy-ethoxy)-1H-pyrazole-3-carboxylic acid (3-carbamoy1-5,5,7,7-tetramethy1-4,7-dihydro-5H-thieno[2,3-c]pyran-2-y1)-amide, 2-[(3-hydroxy-3-methyl-butanoyl)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 5,5,7,7-tetramethy1-2-[[3,3,3-trifluoro-2-(hydroxymethy1)propanoyl]amino]-4H-thieno[2,3-c]pyran-3-carboxamide, 2-(3-hydroxybutanoylamino)-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[1-(1-hydroxyethy1)cyclopropanecarbonyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(2-cyclopropy1-2-hydroxy-acety1)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 5-(1-Hydroxy-ethyl)-1H-pyrazole-3-carboxylic acid (3-carbamoy1-5,5,7,7-tetramethy1-4,7-dihydro-5H-thieno[2,3-c]pyran-2-y1)-amide, 2-(3-Carbamoy1-5,5,7,7-tetramethy1-4,7-dihydro-5H-thieno[2,3-c]pyran-2-ylcarbamoy1)-cyclopropanecarboxylic acid ethyl ester, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-[(E)-3-methoxyprop-1-enyl]-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-5-(1-hydroxy-1-methyl-ethyl)-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(3-methoxypropyl)-1H-pyrazole-3-carboxamide, 2-[(2-hydroxyacetyl)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(3-hydroxy-4-methyl-pentanoyl)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(3-cyclopropy1-3-hydroxy-propanoyl)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 5,5,7,7-tetramethy1-2-[(4,4,4-trifluoro-3-hydroxy-butanoyl)amino]-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(3-hydroxy-2-methyl-propanoyl)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-propy1-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(2-ethoxyethyl)-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-cyano-1H-pyrazole-3-carboxamide, 2[[2-(hydroxymethyl)-3-methyl-butanoyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(1,2-dihydroxyethyl)-1H-pyrazole-3-carboxamide, 2-[[(2S)-2-hydroxy-3,3-dimethyl-butanoyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[(2R)-2-hydroxy-3,3-dimethyl-butanoyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[1-[1-hydroxyethyl]cyclopropanecarbonyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[1-[1-hydroxyethyl]cyclopropanecarbonyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoyl-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-5-(hydroxymethyl)-1-methyl-pyrazole-3-carboxamide, 2-[(2-hydroxy-2,3,3-trimethyl-butanoyl)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2[[2-(hydroxymethy1)cyclopropanecarbonyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[(1 S,2S)-2-(hydroxymethy1)cyclopropanecarbonyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, 2 [[2-(cyclopropylmethyl)-3-hydroxy-propanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2 [[2-(hydroxymethyl)-3,3-dimethyl-butanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2 [2-(hydroxymethy1)butanoylamino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[(1R,3R)-3-(hydroxymethyl)-2,2-dimethyl-cyclopropanecarbonyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(hydroxymethyl)-1H-pyrazole-3-carboxamide, 2 [[2-(hydroxymethyl)-3,3-dimethyl-butanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2 [[2-(hydroxymethyl)-3,3-dimethyl-butanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[1-(hydroxymethy1)-2,2-dimethy1-cyclopropanecarbonyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, [5-[(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1) carbamoyl]pyrazol-1-yl]methyl dihydrogen phosphate, [3-[(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1) carbamoyl]pyrazol-1-yl]methyl dihydrogen phosphate, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(2,3-dihydro-1,4-dioxin-5-y1)-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(1,4-dioxan-2-y1)-1H-pyrazole-3-carboxamide, 2 [[2-(cyclopropylmethyl)-3-hydroxy-propanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, enantiomer 1, 2 [[2-(cyclopropylmethyl)-3-hydroxy-propanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, enantiomer 2, 2-[[(2S)-3-cyclopropy1-2-hydroxy-propanoyl]amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[(1R)-1-(hydroxymethyl)-2,2-dimethyl-cyclopropanecarbonyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(2-methoxyethoxy)-1H-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(2-isopropoxyethoxy)-1H-pyrazole-3-carboxamide, [3-[(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1) carbamoy1]-4-methy1-pyrazol-1-yl]methyl dihydrogen phosphate, [5-[(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1) carbamoyl]-4-methyl-pyrazol-1-yl]methyl dihydrogen phosphate, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-oxo-1,3-dihydroimidazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-(methoxymethyl)-1H-pyrazole-3-carboxamide, 2-[(2-hydroxy-4,4-dimethyl-pentanoy1)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-5-oxo-pyrrolidine-2-carboxamide, (2R)\u2014N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-5-oxo-pyrrolidine-2-carboxamide, 2 [[2-hydroxy-4,4-dimethyl-pentanoy1]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, enantiomer 1, 2 [[2-hydroxy-4,4-dimethy1-pentanoy1]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, enantiomer 2, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-441,4-dioxan-2-y11-1H-pyrazole-3-carboxamide, enantiomer 1, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-[1,4-dioxan-2-y1]-1H-pyrazole-3-carboxamide, enantiomer 2, 2 [[2-(difluoromethoxy)benzoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-1-(difluoromethyl)pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-(difluoromethyflpyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-5-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-1-methyl-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-methyl-pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-1-(2,2,2-trifluoroethyl)pyrazole-3-carboxamide, 2 [[3-(difluoromethy1)benzoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2 [[2-(difluoromethy1)benzoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(3,3-difluoro-1-methyl-cyclobutanecarbonyl)amino]-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-methyl-oxazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-1-(2,2-difluoroethyl) pyrazole-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-(trifluoromethy1) thiazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1) thiazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1) oxazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-(trifluoromethyl)-1H-imidazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-methyl-thiazole-2-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2,4-dimethyl-oxazole-5-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)isoxazole-5-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1) thiazole-5-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4-methyl-oxazole-5-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)oxazole-5-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-1-methyl-5-(trifluoromethyl)pyrazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1) pyrazine-2-carboxamide, 6-butyl-N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-oxo-1H-pyridine-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-3,5-dimethyl-isoxazole-4-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-5-methyl-pyrazine-2-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-1H-pyrrole-2-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-6-methyl-pyridine-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-8-methyl-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-7-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-5-methyl-isoxazole-4-carboxamide, 5,5,7,7-tetramethy1-2-[(3-methyloxetane-3-carbonyl)amino]-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-methyl-4-oxo-3H-quinazoline-5-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-4,7-dimethyl-pyrazolo[5,1-c][1,2,4]triazine-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-methyl-4-oxo-3H-quinazoline-7-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-2-(2,2,2-trifluoroethy1)pyrazole-3-carboxamide, 5,5,7,7-tetramethy1-2-[[(2S)-3,3,3-trifluoro-2-hydroxy-2-methyl-propanoyl]amino]-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[(2S)-2-hydroxypropanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(4-hydroxytetrahydropyran-4-carbony1)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(2-hydroxy-3-methoxy-2-methyl-propanoy1)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(2-hydroxy-3-methoxy-propanoy1)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, N-(3-carbamoy1-5,5,7,7-tetramethy1-4H-thieno[2,3-c]pyran-2-y1)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide, 5,5,7,7-tetramethy1-2-(tetrahydropyran-4-carbonylamino)-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(2-ethoxyacety1)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(2-methoxyacetypamino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[[2-(2-methoxyethoxy)acetyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 5,5,7,7-tetramethy1-2-(tetrahydrofuran-2-carbonylamino)-4H-thieno[2,3-c]pyran-3-carboxamide, 5,5,7,7-tetramethy1-2-(tetrahydrofuran-3-carbonylamino)-4H-thieno[2,3-c]pyran-3-carboxamide, 2-[(2-methoxy-2-methyl-propanoy1)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, 2 [[2-hydroxy-3-methoxy-2-methyl-propanoy1]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, enantiomer 1, 2-[[(2S)-2-hydroxy-3-methoxy-2-methyl-propanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide, enantiomer 2, 5,5,7,7-tetramethy1-2-[(3,3,3-trifluoro-2-hydroxy-propanoyl)amino]-4H-thieno[2,3-c]pyran-3-carboxamide, 6-Oxo-1,6-dihydro-pyridazine-3-carboxylic acid (3-carbamoyl-5,5,7,7-tetramethy1-4,7-dihydro-5H-thieno[2,3-c]pyran-2-y1)-amide, and 2-(1,4-dioxane-2-carboxamido)-5,5,7,7-tetramethy1-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide.

Metadata:
- Claim Count in Document: 30.0
- Percentile: 86.0
- Lexical Diversity: 1.475
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14808200', '14451619', '15143967', '15843917', '15164317']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8205682810529247
- 35 USC 102 Novelty (BERT): 0.6269130423949157
- Combined Prediction Score: 0.8012027571871237
- Mean Citation Score: 514.236832
- Max Citation Score: 581.739
- Similarity Product: 522.6325889312625

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test