PATENT CLAIM ANALYSIS

Application Number: 15752498
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "007210"]

Abstract:
Provided are a biomarker for evaluating a cerebral Aβ accumulation state using amyloid precursor protein (APP)-derived Aβ and Aβ-like peptides in a living body-derived sample as an index, and a method for analysis thereof. A marker for determining a cerebral Aβ accumulation state, the marker comprising a combination of at least two ratios selected from the group consisting of: a ratio of Aβ1-39 (SEQ ID NO.: 1) level to Aβ1-42 (SEQ ID NO.: 3) level: Aβ1-39/Aβ1-42; a ratio of Aβ1-40 (SEQ ID NO.: 2) level to Aβ1-42 (SEQ ID NO.: 3) level: Aβ1-40/Aβ1-42; and a ratio of APP669-711 (SEQ ID NO.: 4) level to Aβ1-42 (SEQ ID NO.: 3) level: APP669-711/Aβ1-42, in a living body-derived sample.

Claim (Index 6):
The analytical method according to  claim 2 , wherein the mathematical technique is a method of normalizing each of the aforementioned ratios, and then deriving a mean value or a total value of the at least two ratios normalized.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 88.0
- Lexical Diversity: 2.29851
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13874052', '13744223', '14435520', '12812712', '14559301']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6128923875728418
- 35 USC 102 Novelty (BERT): 0.5242353272831994
- Combined Prediction Score: 0.6040266815438775
- Mean Citation Score: 259.427202
- Max Citation Score: 267.0504
- Similarity Product: 124.31308261578084

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test