PATENT CLAIM ANALYSIS

Application Number: 15865963
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "094000"]

Abstract:
The present invention discloses compounds according to Formula I: wherein R 1  is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.

Claim (Index 1):
A method for the treatment of cystic fibrosis, comprising administering to a subject an effective amount of a compound according to Formula I wherein\n R 1  is\n C 3-7  mono or spirocyclic cycloalkyl, optionally substituted with one or more independently selected R 2  groups, \n 4-7 membered mono or spirocyclic heterocycloalkyl comprising one or more heteroatoms independently selected from O, N, and S, substituted with one or more independently selected R 2  groups, \n C 6-10  monocyclic or bicyclic aryl optionally substituted with one or more independently selected R 3  groups, \n 5-10 membered monocyclic or fused bicyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, and S, and optionally substituted with one or more independently selected R 3  groups, or \n C 1-6  alkyl optionally substituted with one or more independently selected R 4  groups, \n \n each R 2  is selected from\n halo, \n OH, \n \u2014CN, \n \u2014OC(\u2550O)C 1-4  alkyl, \n \u2014C(\u2550O)\u2014C 1-4  alkoxy, \n oxo, \n C 1-4  alkyl (optionally substituted with one or more independently selected R 5a ), and \n C 1-4  alkoxy (optionally substituted with one or more independently selected R 5a ), \n \n each R 3  is selected from\n halo, \n OH, \n \u2014CN, \n C 1-4  alkyl (optionally substituted with one or more independently selected R 5b ), \n C 1-4  alkoxy (optionally substituted with one or more independently selected R 5b ), \n C 2-4  alkenyl (optionally substituted with one or more independently selected R 5b ), \n C 3-7  cycloalkyl, \n 4-7 membered monocyclic heterocycloalkyl comprising one or more heteroatoms independently selected from N, O, and S, \n 4-7 membered monocyclic heterocycloalkenyl comprising one or more heteroatoms independently selected from N, O, and S, \n 5-10 membered monocyclic or fused bicyclic heteroaryl comprising one or more heteroatoms independently selected from N, O, and S, and \n \u2014NHSO 2 \u2014C 1-4  alkyl; \n \n each R 4  is selected from\n halo, \n OH, \n C 3-7  monocyclic cycloalkyl, \n \u2014CN, and \n C 1-4  alkoxy (optionally substituted with one or more independently selected R 5c ), \n each R 5a , R 5b , and R 5c  is independently selected from\n halo, \n OH, \n \u2014OP(\u2550O) 2 OH, \n \u2014CN, \n \u2014NR 6a R 6b , and \n C 1-4  alkoxy; and \n \n each R 6a , or R 6b  is independently selected from H, and C 1-4  alkyl; or a pharmaceutically acceptable salt, or a solvate, or a pharmaceutically acceptable salt of a solvate thereof.

Metadata:
- Claim Count in Document: 30.0
- Percentile: 86.0
- Lexical Diversity: 1.475
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14808200', '14451619', '15143967', '15843917', '15164317']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7987867889962327
- 35 USC 102 Novelty (BERT): 0.6384186712503881
- Combined Prediction Score: 0.7827499772216482
- Mean Citation Score: 514.236832
- Max Citation Score: 581.739
- Similarity Product: 575.004444410026

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test