PATENT CLAIM ANALYSIS

Application Number: 16014231
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "259300"]

Abstract:
Compounds of Formula 0, Formula I, and Formula II and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

Claim (Index 3):
The compound of  claim 1 , further defined as a compound of Formula II: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein: R 1  is hydrogen or halogen; R 3  is hydrogen, halogen, CN, OH, C 1-3 alkyl, C 2-3 alkenyl, C 3-7 cycloalkyl group, C 1 -C 3 alkanoyl, \u2014(C 0 -C 3 alkyl)C(O)NR 6 R 7 , \u2014(C 2-3 alkenyl)C(O)NR 6 R 7 , \u2014S(O) 1-2 NR 6 R 7 , \u2014NR 8 R 9 , a 3-7 membered monocyclic saturated or partially saturated heterocyclic group, a 5-6 membered monocyclic heteroaryl ring, or a 5-6 membered monocyclic aryl ring, wherein any alkyl, alkanoyl, or alkenyl is independently optionally substituted by halogen, oxo, CN, OH, C 1-3 alkoxy, or C 1-3 haloalkoxy, and any cycloalkyl group or other ring is independently optionally substituted by halogen, oxo, CN, OH, C 1-3 alkyl, or C 1-3 haloalkyl; R 4  is hydrogen, halogen, C 1-3 alkyl, C 2-3 alkenyl, \u2014(C 0 -C 3 alkyl)C(O)R 13  \u2014(C 2-3 alkenyl)C(O)NR 10 R 11 , \u2014S(O) 12 NR 10 R 11 , or \u2014NR 8 R 9 ; wherein any alkyl or alkenyl is independently optionally substituted by halogen, oxo, CN, OH, C 1-3 alkoxy, or C 1-3 haloalkoxy; R 5  is hydrogen, C 1-6 alkyl, C 1-6 alkoxy, C 3-10 cycloalkyl group, \u2014NR 8 R 9 , \u2014O(C 3-7 cycloalkyl group), a 3-11 membered saturated or partially saturated heterocyclic group, or a 5-6 membered monocyclic heteroaryl ring, wherein any alkyl or alkoxy is independently optionally substituted by halogen, oxo, CN, OH, C 1-3 alkoxy, or C 1-3 haloalkoxy, and any cycloalkyl group or other ring is optionally substituted by halogen, oxo, CN, OH, \u2014(C 0 -C 3 alkyl)C(O)NR 10 R 11 , \u2014OP(O)(OC 1-3 alkyl) 2 , or C 1-3 alkyl optionally substituted by halogen, oxo, CN, OH, or \u2014NR 8 R 9 ; A is a 3-11 membered heterocyclic group optionally substituted by halogen, oxo, CN, OH, C 1-6 alkyl, C 3-6 cycloalkyl group, \u2014NR 8 R 9 , \u2014NR 12 C(O)R 13 , \u2014NR 12 S(O) 12 R 13 , \u2014C(O)NR 10 R 11 , \u2014C(O)OR 13 , or \u2014S(O) 1-2 NR 10 R 11 , wherein any alkyl or cycloalkyl group is independently optionally substituted by halogen, oxo, CN, OH, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, or C 1-3 haloalkoxy; wherein when A is a 5-membered nitrogen containing heterocyclic group, the nitrogen atom is substituted; R 6  and R 7  are, independently at each occurrence, hydrogen, C 1-3 alkyl, or C 3-6 cycloalkyl group, wherein any alkyl or cycloalkyl group is independently optionally substituted by halogen, oxo, CN, OH, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, or C 1-3 haloalkoxy; R 8 , R 9 , R 10  and R 11  are, independently at each occurrence, hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl group, a 3-11 membered saturated heterocyclic group, \u2014C(O)R 13 , \u2014C(O)OR 13 , \u2014C(O)NR 6 R 7 , or \u2014S(O) 1-2 R 13 , wherein any alkyl, cycloalkyl group or other ring is independently optionally substituted by halogen, oxo, CN, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, \u2014OR 13 , or \u2014NR 6 R 7 ; R 12  is, independently at each occurrence, hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl group, wherein any alkyl or cycloalkyl group is independently optionally substituted by halogen, oxo, CN, OH, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, or C 1-3 haloalkoxy; R 13  is, independently at each occurrence, hydrogen, C 1-6 alkyl, C 3-10 cycloalkyl group, or a 3-11 membered saturated heterocyclic group, wherein any alkyl, cycloalkyl group, or other ring is independently optionally substituted by halogen, oxo, CN, OH, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, \u2014OR 12 , or \u2014NR 6 R 7 ; and R 16  is H, \u2014Cl, \u2014CN, or \u2014CH 3 .

Metadata:
- Claim Count in Document: 17.0
- Percentile: 94.0
- Lexical Diversity: 1.21739
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15905524', '15305390', '15247429', '15822493', '15305372']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8214374503499763
- 35 USC 102 Novelty (BERT): 0.5496930932466234
- Combined Prediction Score: 0.794263014639641
- Mean Citation Score: 404.523194
- Max Citation Score: 418.23807
- Similarity Product: 319.5450779719913

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test