PATENT CLAIM ANALYSIS

Application Number: 15901517
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["528", "371000"]

Abstract:
The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.

Claim (Index 78):
A polymerization catalyst having the structure: wherein:\n M is a metal atom; \n comprises a multidentate ligand; and (Z) m  represents one or more activating moiety tethered to the multidentate ligand, where   represents a linker moiety; m represents the number of Z groups present on a linker moiety and is an integer between 1 and 4 inclusive; and each (Z) is an activating functional group independently selected from the group consisting of: wherein: each occurrence of R 1 , R 2  and R 3  is independently hydrogen or an optionally substituted radical selected from the group consisting of C 1-20  aliphatic; C 1-20  heteroaliphatic; phenyl; a 3- to 8-membered saturated or partially unsaturated monocyclic carbocycle, a 7-14 carbon saturated, partially unsaturated or aromatic polycyclic carbocycle; a 5- to 6-membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 3- to 8-membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 6- to 12-membered polycyclic saturated or partially unsaturated heterocycle having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an 8- to 10-membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein two or more R 1 , R 2  and R 3  groups can be taken together with intervening atoms to form one or more optionally substituted rings optionally containing one or more additional heteroatoms; R 4\u2032  is hydrogen, hydroxyl, optionally substituted C 1-20  aliphatic; each occurrence of R 5  is independently hydrogen or an optionally substituted radical selected from the group consisting of C 1-20  aliphatic; C 1-20  heteroaliphatic; phenyl; a 3- to 8-membered saturated or partially unsaturated monocyclic carbocycle, a 7-14 carbon saturated, partially unsaturated or aromatic polycyclic carbocycle; a 5- to 6-membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 3- to 8-membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 6- to 12-membered polycyclic saturated or partially unsaturated heterocycle having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an 8- to 10-membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein an R 5  group can be taken with an R 1  or R 2  group to form one or more optionally substituted rings; each occurrence of R 7  is independently hydrogen, a hydroxyl protecting group, or an optionally substituted radical selected from the group consisting of C 1-20  acyl; C 1-20  aliphatic; C 1-20  heteroaliphatic; phenyl; a 3- to 8-membered saturated or partially unsaturated monocyclic carbocycle, a 7-14 carbon saturated, partially unsaturated or aromatic polycyclic carbocycle; a 5- to 6-membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 3- to 8-membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 6- to 12-membered polycyclic saturated or partially unsaturated heterocycle having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an 8- to 10-membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, where an R 7  group can be taken with an R 5  group to form one or more optionally substituted rings optionally containing one or more heteroatoms; each occurrence of R 7\u2032 , is independently hydrogen, a hydroxyl protecting group, or an optionally substituted radical selected from the group consisting of C 1-20  acyl; C 1-20  aliphatic; C 1-20  heteroaliphatic; phenyl; a 3- to 8-membered saturated or partially unsaturated monocyclic carbocycle, a 7-14 carbon saturated, partially unsaturated or aromatic polycyclic carbocycle; a 5- to 6-membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 3- to 8-membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 6- to 12-membered polycyclic saturated or partially unsaturated heterocycle having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an 8- to 10-membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; and where two R 7\u2032  groups can be taken together with intervening atoms to form one or more optionally substituted rings optionally containing one or more heteroatoms, and an R 7\u2032  group can be taken with an R 1  or R 2  group to form one or more optionally substituted rings optionally containing one or more heteroatoms; each occurrence of R 8 , R 9 , and R 10  is independently hydrogen or an optionally substituted radical selected from the group consisting of C 1-20  aliphatic; C 1-20  heteroaliphatic; phenyl; a 3- to 8-membered saturated or partially unsaturated monocyclic carbocycle, a 7-14 carbon saturated, partially unsaturated or aromatic polycyclic carbocycle; a 5- to 6-membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 3- to 8-membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 6- to 12-membered polycyclic saturated or partially unsaturated heterocycle having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an 8- to 10-membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein any two or more R 8 , R 9  and R 10  groups can be taken together with intervening atoms to form one or more optionally substituted rings; each occurrence of R 11  is independently selected from the group consisting of: halogen, \u2014NO 2 , \u2014CN, \u2014SR y , \u2014S(O)R y , \u2014S(O) 2 R y , \u2014NR y C(O)R y , \u2014OC(O)R y , \u2014CO 2 R y , \u2014NCO, \u2014N 3 , \u2014OR 7 , \u2014OC(O)N(R y ) 2 , \u2014N(R y ) 2 , \u2014NR y C(O)R y , \u2014NR y C(O)OR y ; or an optionally substituted radical selected from the group consisting of C 1-20  aliphatic; C 1-20  heteroaliphatic; phenyl; a 3- to 8-membered saturated or partially unsaturated monocyclic carbocycle, a 7-14 carbon saturated, partially unsaturated or aromatic polycyclic carbocycle; a 5- to 6-membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 3- to 8-membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 6- to 12-membered polycyclic saturated or partially unsaturated heterocycle having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an 8- to 10-membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, where each occurrence of R y  is independently selected from the group consisting of hydrogen an optionally substituted C 1-6  aliphatic group, and an optionally substituted aryl group, where two or more adjacent R 11  groups can be taken together to form an optionally substituted saturated, partially unsaturated, or aromatic 5- to 12-membered ring containing 0 to 4 heteroatoms; X is an anion; ring A is an optionally substituted 5- to 10-membered heteroaryl group having 0 to 4 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur; with the provisos that:\n when Z is \n ring A is not an imidazole, an oxazole, or a thiazole; and when where   is \u2014CH 2 \u2014\n Z is not

Metadata:
- Claim Count in Document: 67.0
- Percentile: 88.0
- Lexical Diversity: 1.4375
- Patent Class: 528.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15251668', '13059967', '13755120', '13755112', '13755126']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8304112045586313
- 35 USC 102 Novelty (BERT): 0.5731413420618471
- Combined Prediction Score: 0.8046842183089529
- Mean Citation Score: 485.4526900000001
- Max Citation Score: 496.68454
- Similarity Product: 390.2360843625213

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test