PATENT CLAIM ANALYSIS

Application Number: 15967202
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["435", "069600"]

Abstract:
The present invention provides recombinant cells that contain a genetic modification to at least one mannosyl transferase gene. As a result of the modification the cells produce a glycoprotein or glycopeptide that has an N-linked glycan profile that is simplified or more easily humanized. The glycoprotein or glycopeptide can have at least 25% fewer high mannose structures on than the glycoprotein or glycopeptide produced by a reference cell. In some embodiments the modification is a deletion or disruption of a mannosyl transferase gene, which can be in an alg3 gene. Therefore, the proteins produced are more useful for the production of therapeutic glycoproteins than those produced by species having foreign or plant-like patterns of glycosylation. The invention also provides compositions of the glycoproteins or glycopeptides and methods of making them.

Claim (Index 10):
The cell of  claim 3  wherein the glycoprotein or glycopeptide comprises at least 25% fewer xylose moieties than the cell that does not comprise the mannosyl transferase deletion.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 91.0
- Lexical Diversity: 1.6747
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15799785', '15327448', '13989084', '10500240', '14354160']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6348403656757761
- 35 USC 102 Novelty (BERT): 0.6561213531906487
- Combined Prediction Score: 0.6369684644272633
- Mean Citation Score: 410.495272
- Max Citation Score: 742.8057
- Similarity Product: 594.1792637168527

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test