PATENT CLAIM ANALYSIS

Application Number: 15865806
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["800", "013000"]

Abstract:
Methods and kits for the diagnosis of illnesses related to protocadherin 19 (PCDH19) protein deficiency or altered PCDH19 protein function are provided, as well as methods and kits for the identification of a predisposition to such illnesses and methods of screening subjects to identify carriers of such illnesses and methods and kits for the therapeutic or prophylactic treatment of PCDH19 deficiency or altered PCDH19 protein function. Further, nucleotide and amino acid sequences corresponding to a complete PCDH19 open reading frame (ORF), mutant sequences encoding non-functional PCDH19 mRNA or altered PCDH19 mRNA are described along with transformed cells and non-human transgenic animals comprising wild-type or mutant PCDH19 ORF nucleotide sequences.

Claim (Index 11):
A method for the therapeutic or prophylactic treatment of a protocadherin 19 (PCDH19) protein deficiency or an altered PCDH19 protein function in a subject, wherein said method comprises the step of:\n (i) administering to the subject a polynucleotide molecule comprising a nucleotide sequence showing at least 70% sequence identity to the complete protocadherin 19 (PCDH19) open reading frame (ORF) nucleotide sequence according to SEQ ID NO: 1, wherein said nucleotide sequence encodes a functional PCDH19 protein or polypeptide, or a functional fragment or a functional variant thereof; or a functional PCDH19 protein or polypeptide, or a functional fragment or a functional variant thereof encoded by a polynucleotide molecule comprising a nucleotide sequence showing at least 70% sequence identity to the complete PCDH19 ORF nucleotide sequence according to SEQ ID NO: 1; or an agent that compensates for PCDH19 function.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 1.87302
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12735324', '09689952', '13501447', '09659737', '10444795']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5459840363209753
- 35 USC 102 Novelty (BERT): 0.5526496025595791
- Combined Prediction Score: 0.5466505929448356
- Mean Citation Score: 289.3974800000001
- Max Citation Score: 479.41205
- Similarity Product: 294.6983397654474

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test