PATENT CLAIM ANALYSIS

Application Number: 15910218
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "093700"]

Abstract:
The present invention provides a method for isolating human neural stem cells from amniotic fluid of a patient whose fetus has been diagnosed to have a neural tube defect. Use of the isolated human neural stem cells in the treatment of neurological disorders is also provided.

Claim (Index 1):
A method for treating a neurological condition in a mammal in need thereof, comprising administering an isolated human neural stem cells or a pharmaceutical composition comprising the isolated human neural stem cells to the mammal,\n wherein the isolated human neural stem cells are obtained from a method consisting of: (a) collecting the cells from amniotic fluid obtained from a pregnant human subject whose fetus has been diagnosed to have a neural tube defect; (b) incubating the cells with a culture medium; (c) detecting expression levels of Nestin, Sox2, Musashi-1, and ATP-binding cassette G2 (ABCG2) markers and activity of Stage-Specific Embryonic Antigen-3 (SSEA-3), Stage-Specific Embryonic Antigen-4 (SSEA-4), Tumor Rejection Antigen-1-60 (TRA-1-60), TRA-1-81 and telomerase in the cells; and (d) isolating from the culture medium human neural stem cells that express Nestin, Sox2, Musashi-1 and ABCG2 markers and exhibit telomerase activity but do not express SSEA-3, SSEA-4, TRA-1-60 and TRA-1-81 from the culture medium.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 90.0
- Lexical Diversity: 1.2973
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14660554', '14396180', '12182050', '15297972', '13504988']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.687889933430354
- 35 USC 102 Novelty (BERT): 0.7134709960019424
- Combined Prediction Score: 0.6904480396875129
- Mean Citation Score: 424.68344
- Max Citation Score: 824.89417
- Similarity Product: 730.0195323774409

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test