PATENT CLAIM ANALYSIS

Application Number: 15953083
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "178000"]

Abstract:
The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated by NFkB, IL-6, IL-6-R, NADPH oxidase (Nox), and/or superoxide and/or hydrogen peroxide production by a NADPH oxidase, including for example ameliorating, treating, reversing or preventing schizophrenia, psychosis, delirium, e.g., post-operative delirium, drug-induced psychosis, psychotic features associated with frailty syndrome (FS), aging, depression, dementias; traumatic war neurosis, post traumatic stress disorder (PTSD) or post-traumatic stress syndrome (PTSS), Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease), and/or Multiple Sclerosis (MS). The invention also provides methods for purifying a C60 fullerene, C 3  (tris malonic acid C60) or malonic acid derivatives.

Claim (Index 20):
The method of  claim 12 , wherein the C60 malonic acid (propanedioic acid) derivative is purified by a method comprising:\n (i)\n (a) providing a solution comprising an impure powder form of a C60 malonic acid derivative, wherein optionally the C60 malonic acid derivative is or comprises a C 3  tris malonic acid C60 fullerene or a C60 macrocyclic malonate derivative, and optionally the malonate is functionalized with a halide atom, or malonate ester groups are replaced by alkyne groups, optionally as a dialkynylmethanofullerene; \n (b) providing an antibody directed against a C60 fullerene or a C60 malonic acid derivative, wherein optionally the C60 malonic acid derivative is a C 3  tris malonic acid C60 fullerene; and \n (c) isolating the C60 fullerene or the C60 malonic acid derivative by incubating the antibody with the C60 fullerene or the C60 malonic acid derivative under conditions wherein the antibody specifically binds to the C60 fullerene, or the C60 malonic acid derivative; or \n (ii) the method of (i), wherein an antibody-C60 fullerene complex or an antibody-C 3  tris malonic acid C60 fullerene or antibody-malonic acid derivative complex is purified by gel electrophoresis purification, HPLC, immunoprecipitation, column chromatography, differential centrifugation or affinity column chromatography.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 91.0
- Lexical Diversity: 1.81818
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15136787', '12681743', '14358571', '13970639', '14888390']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7368203171305853
- 35 USC 102 Novelty (BERT): 0.6787413057217118
- Combined Prediction Score: 0.7310124159896979
- Mean Citation Score: 411.3179859999999
- Max Citation Score: 801.0581
- Similarity Product: 631.4789048551321

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test