PATENT CLAIM ANALYSIS

Application Number: 15932658
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["073", "590000"]

Abstract:
An active pharmaceutical ingredients (API) or related substance (RS) can be tested for stability by placing the API or RS in an instrument containing a pressure-controllable atmosphere, controlling the pressure of the atmosphere in the instrument for a predetermined time, and evaluating the API or RS for stability. Testing can be carried out also at predetermined temperature(s) and/or under the influence of gaseous trigger(s) and so forth. For instance, an API sample can be placed in a bomb test instrument/reactor, oxygen as a gaseous trigger can be introduced to contact the API sample under constant and/or ramped temperature(s) and elevated pressure(s) for predetermined time(s), and the API sample can be evaluated for stability. An insert carousel may hold a sample of API(s) and/or RS(s) and/or aliquot(s) of sample(s) of API(s) and/or RS(s) for insertion into the bomb test instrument/reactor.

Claim (Index 6):
The method of  claim 3 , wherein the bomb test instrument/reactor is a rotatable bomb device, which includes a rotatable bomb device including a stationary housing with a hollow interior for receipt of a rotatable component to a vessel, with support for the rotatable component in the interior, and including, in the housing, the rotatable component, in which the rotatable component is or includes an inner container that will be rotated by magnetic interaction of a magnet which is coupled to the rotatable component or the inner container and a rotating magnet driver outside the hollow interior, which further includes a provision in the rotatable bomb device of at least one of the members (A, B, C, D, E, F) of the group consisting of:\n A) an insulating lower disc or washer located inside, bottom of the stationary housing, which provides for additional control of temperature by blocking energy that otherwise would be lost at the bottom of the stationary housing from the rotatable component, and which can be employed in lieu of pegs or feet on the bottom of the rotatable component that would provide an air gap for insulating heat loss and reduce bottom friction; B) a plurality of staggered heating bands encompassing the stationary housing, each of which able to be controlled or turned off independently of the other(s); C) a dry scan port in the stationary housing, accessible from outside the housing, front, into which a thermocouple or temperature sensor can be inserted and slid to any appropriate depth or position to tune or calibrate temperature; D) a rear upper port in the stationary housing, accessible from outside the housing, rear, into which a thermocouple or temperature sensor can be inserted and slid to any appropriate depth or position to monitor temperature during use of the bomb; E) a rear lower port in the stationary housing, accessible from outside the housing, rear, into which a thermocouple or temperature sensor can be inserted and slid to any appropriate depth or position to monitor temperature during use of the bomb; F) an extraction/injection fitting for access to the interior of the stationary housing through a lid thereto, which includes a tubular support system and a three-way valve and locking syringe system for employment therewith.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 91.0
- Lexical Diversity: 2.56944
- Patent Class: 73.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13998187', '12589442', '11510173', '11006456', '11563639']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7396285401663074
- 35 USC 102 Novelty (BERT): 0.4733779848460966
- Combined Prediction Score: 0.7130034846342863
- Mean Citation Score: 178.035686
- Max Citation Score: 227.29768
- Similarity Product: 198.35205824342728

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test