PATENT CLAIM ANALYSIS

Application Number: 15994502
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-03
Patent Classification: ["514", "183000"]

Abstract:
The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to bisantrene or derivatives, analogs, or prodrugs thereof.

Claim (Index 12):
A composition to improve the efficacy and/or reduce the side effects of suboptimally administered drug therapy comprising a therapeutically effective quantity of a therapeutic agent or modified therapeutic agent, wherein the composition:\n (a) is formulated for use in a program of dose modification; (b) is formulated for use in a program of alteration or modification of route of administration; (c) is formulated for use in a program of alteration or modification of schedule of administration; (d) is formulated for use in a program of selecting appropriate indications for use; (e) is formulated for use in a program of selecting appropriate disease stages for use; (f) is formulated for use in a program of selecting appropriate additional indications for use; (g) is formulated for use in a program of selecting appropriate patients for use of the composition; (h) is formulated for use in a program of selecting appropriate patient or disease phenotypes for use of the composition; (i) is formulated for use in a program of selecting appropriate patient or disease genotypes for use of the composition; (j) is formulated for use in a program of toxicity management; (k) is formulated for use in a program of pre/post-treatment management; (l) is formulated for use in a program of post-treatment management; (m) is formulated for use in a program of alternative medicine/therapeutic support; (n) is formulated for use in a program of biotherapeutic enhancement; (o) is formulated for use in a program of biotherapeutic resistance modulation; (p) is formulated for use in a program of radiation therapy enhancement; (q) is formulated for use to employ novel mechanisms of action in its therapeutic activity; (r) is formulated for use in a program of selective target cell population therapeutics; (s) is formulated for use in a program of modulating DNA methylation; (t) is formulated for use in a program of inhibiting telomerase or inducing telomere dysfunction; (u) is formulated for use in a program of activating macrophages and/or inducing innate and/or adaptive immunity; (v) is formulated for use in a program of inhibiting survivin; (w) further comprises a diluent; (x) further comprises a solvent system; (y) further comprises an excipient; (z) is incorporated into a dosage kit and packaging; (aa) comprises a drug delivery system; or (ab) is formulated to optimize an immunological response; wherein the therapeutic agent or the modified therapeutic agent in the composition possesses increased therapeutic efficacy or reduced side effects as compared with the therapeutic agent or unmodified therapeutic agent as administered individually and not in the composition, wherein the unmodified therapeutic agent is bisantrene or a derivative or analog of bisantrene, and the modified therapeutic agent is a modification of bisantrene or a derivative or analog of bisantrene.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 1.31579
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15979041', '14907728', '14907729', '13817096', '14250958']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7742520861840011
- 35 USC 102 Novelty (BERT): 0.5302472501858224
- Combined Prediction Score: 0.7498516025841833
- Mean Citation Score: 276.52593
- Max Citation Score: 362.98706
- Similarity Product: 314.36195938445326

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test