PATENT CLAIM ANALYSIS

Application Number: 15571475
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["514", "330000"]

Abstract:
Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.

Claim (Index 55):
The compound of  claim 54 , or a pharmaceutically acceptable salt thereof, having the formula: or a pharmaceutically acceptable salt thereof, wherein:\n E is: \n \u2003wherein:\n R 16  is hydrogen, halogen, \u2014CX 16 3 , \u2014CHX 16 2 , \u2014CH 2 X 16 , \u2014CN, \u2014SO n16 R 16D , \u2014SO v16 NR 16A R 16B , \u2014NHNR 16A R 16B , \u2014ONR 16A R 16B , \u2014NHC\u2550(O)NHNR 16A R 16B , \u2014NHC(O)NR 16A R 16B , \u2014N(O) m16 , \u2014NR 16A R 16B , \u2014C(O)R 16C , \u2014C(O)\u2014OR 16C , \u2014C(O)NR 16A R 16B , \u2014OR 16D , \u2014NR 16A SO 2 R 16D , \u2014NR 16A C(O)R 16C , \u2014NR 16A C(O)OR 16C , \u2014NR 16A OR 16C , \u2014OCX 16 3 , \u2014OCHX 16 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; \n R 17  is hydrogen, halogen, \u2014CX 17 3 , \u2014CHX 17 2 , \u2014CH 2 X 17 , \u2014CN, \u2014SO n17 R 17D , \u2014SO v17 NR 17A R 17B , \u2014NHNR 17A R 17B , \u2014ONR 17A R 17B , \u2014NHC\u2550(O)NHNR 17A R 17B , \u2014NHC(O)NR 17A R 17B , \u2014N(O) m17 , \u2014NR 17A R 17B , \u2014C(O)R 17C , \u2014C(O)\u2014OR 17C , \u2014C(O)NR 17A R 17B , \u2014OR 17D , \u2014NR 17A SO 2 R 17D , \u2014NR 17A C(O)R 17C , \u2014NR 17A C(O)OR 17C , \u2014NR 17A OR 17C , \u2014OCX 17 3 , \u2014OCHX 17 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; \n R 18  is hydrogen, halogen, \u2014CX 18 3 , \u2014CHX 18 2 , \u2014CH 2 X 18 , \u2014CN, \u2014SO n18 R 18D , \u2014SO v18 NR 18A R 18B , \u2014NHNR 18A R 18B , \u2014ONR 18A R 18B , \u2014NHC\u2550(O)NHNR 18A R 18B , \u2014NHC(O)NR 18A R 18B , \u2014N(O) m18 , \u2014NR 18A R 18B , \u2014C(O)R 18C , \u2014C(O)\u2014OR 18C , \u2014C(O)NR 18A R 18B , \u2014OR 18D , \u2014NR 18A SO 2 R 18D , \u2014NR 18A C(O)R 18C , \u2014NR 18A C(O)OR 18C , \u2014NR 18A OR 18C , \u2014OCX 18 3 , \u2014OCHX 18 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; \n R 16A , R 16B , R 16C , R 16D , R 17A , R 17B , R 17C , R 17D , R 18A , R 18B , R 18C , and R 18D  are independently hydrogen, halogen, \u2014CX 3 , \u2014CN, \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 3 H, \u2014SO 4 H, \u2014SO 2 NH 2 , \u2014NHNH 2 , \u2014ONH 2 , \u2014NHC(O)NHNH 2 , \u2014NHC(O)NH 2 , \u2014NHSO 2 H, \u2014NHC(O)H, \u2014NHC(O)OH, \u2014NHOH, \u2014OCX 3 , \u2014OCHX 2 , \u2014CHX 2 , \u2014CH 2 X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 16A  and R 16B  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R 17A  and R 17B  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R 18A  and R 18B  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; \n each X, X 16 , X 17 , and X 18  is independently \u2014F, \u2014Cl, \u2014Br, or \u2014I; \n n16, n17, n18, v16, v17, and v18 are independently an integer from 0 to 4; and \n m16, m17, and m18 are independently 1 or 2; or \n \u2003wherein: R 16  is independently halogen, \u2014CX 16 3 , \u2014CHX 16 2 , \u2014CH 2 X 16 , \u2014CN, \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 3 H, \u2014SO 4 H, \u2014SO 2 NH 2 , \u2014NHNH 2 , \u2014ONH 2 , \u2014NHC(O)NHNH 2 , \u2014NHC(O)NH 2 , \u2014NHSO 2 H, \u2014NHC(O)H, \u2014NHC(O)OH, \u2014NHOH, \u2014OCX 16 3 , \u2014OCHX 16 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; Y 2  is N or CH; z16 is an integer from 0 to 4; and each X 16  is independently \u2014F, \u2014Cl, \u2014Br, or \u2014I; or \u2003wherein: R 16  is hydrogen, halogen, \u2014CX 16 3 , \u2014CHX 16 2 , \u2014CH 2 X 16 , \u2014CN, \u2014SO n16 R 16D , \u2014SO v16 NR 16A R 16B , \u2014NHNR 16A R 16B , \u2014ONR 16A R 16B , \u2014NHC\u2550(O)NHNR 16A R 16B , \u2014NHC(O)NR 16A R 16B , \u2014N(O) m16 , \u2014NR 16A R 16B , \u2014C(O)R 16C , \u2014C(O)\u2014OR 16C , \u2014C(O)NR 16A R 16B , \u2014OR 16D , \u2014NR 16A SO 2 R 16D , \u2014NR 16A C(O)R 16C , \u2014NR 16A C(O)OR 16C , \u2014NR 16A OR 16C , \u2014OCX 16 3 , \u2014OCHX 16 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; R 17  is hydrogen, halogen, \u2014CX 17 3 , \u2014CHX 17 2 , \u2014CH 2 X 17 , \u2014CN, \u2014SO n17 R 17D , \u2014SO v17 NR 17A R 17B , \u2014NHNR 17A R 17B , \u2014ONR 17A R 17B , \u2014NHC\u2550(O)NHNR 17A R 17B , \u2014NHC(O)NR 17A R 17B , \u2014N(O) m17 , \u2014NR 17A R 17B , \u2014C(O)R 17C , \u2014C(O)\u2014OR 17C , \u2014C(O)NR 17A R 17B , \u2014OR 17D , \u2014NR 17A SO 2 R 17D , \u2014NR 17A C(O)R 17 , \u2014NR 17A C(O)OR 17C , \u2014NR 17A OR 17C , \u2014OCX 17 3 , \u2014OCHX 17 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; R 18  is \u2014CN; R 16A , R 16B , R 16C , R 16D , R 17A , R 17B , R 17C , and R 17D  are independently hydrogen, halogen, \u2014CX 3 , \u2014CN, \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 3 H, \u2014SO 4 H, \u2014SO 2 NH 2 , \u2014NHNH 2 , \u2014ONH 2 , \u2014NHC(O)NHNH 2 , \u2014NHC(O)NH 2 , \u2014NHSO 2 H, \u2014NHC(O)H, \u2014NHC(O)OH, \u2014NHOH, \u2014OCX 3 , \u2014OCHX 2 , \u2014CHX 2 , \u2014CH 2 X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 16A  and R 16B  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R 17A  and R 17B  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; each X, X 16 , and X 17  is independently \u2014F, \u2014Cl, \u2014Br, or \u2014I; n16, n17, v16, and v17 are independently an integer from 0 to 4; and m16 and m17 are independently 1 or 2; Y is N or CH; Ring A is a C 3 -C 7  cycloalkyl or 3 to 7 membered heterocycloalkyl; R 1  is independently halogen, \u2014CX 1 3 , \u2014CHX 1 2 , \u2014CH 2 X 1 , \u2014CN, \u2014SO 2 Cl, \u2014SO n1 R 10 , \u2014SO v1 NR 7 R 8 , \u2014NHNR 7 R 8 , \u2014ONR 7 R 8 , \u2014NHC\u2550(O)NHNR 7 R 8 , \u2014NHC(O)NR 7 R 8 , \u2014N(O) m1 , \u2014NR 7 R 8 , \u2014C(O)R 9 , \u2014C(O)\u2014OR 9 , \u2014C(O)NR 7 R 8 , \u2014OR 10 , \u2014NR 7 SO 2 R 10 , \u2014NR 7 C(O)R 9 , \u2014NR 7 C(O)OR 9 , \u2014NR 7 OR 9 , \u2014OCX 1 , \u2014OCHX 1 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; two adjacent R 1  substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L 1  is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene; L 2  is a bond, \u2014O\u2014, \u2014C(O)\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014S(O) 2 \u2014, \u2014NR 7B \u2014, \u2014NR 7B C(O)\u2014, \u2014C(O)NR 7B \u2014, \u2014SO 2 NR 7B \u2014, \u2014NR 7B SO 2 \u2014, \u2014OC(O)NR 7B \u2014, \u2014NR 7B C(O)O\u2014, \u2014CR 9B \u2550NO\u2014, \u2014ON\u2550CR 9B \u2014, \u2014NR 8B C(O)NR 7B \u2014, \u2014NR 8B C(\u2550NR 10B )NR 7B \u2014, \u2014NR 8B C(\u2550NR 10B )\u2014, \u2014C(\u2550NR 10B )NR 7B \u2014, \u2014OC(\u2550NR 10B )\u2014, \u2014C(\u2550NR 10B )O\u2014, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene; L 4  is a bond, \u2014O\u2014, \u2014C(O)\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014S(O) 2 \u2014, \u2014NR 4 \u2014, \u2014NR 4 C(O)\u2014, \u2014C(O)NR 4 \u2014, \u2014SO 2 NR 4 \u2014, \u2014NR 4 SO 2 \u2014, \u2014NR 4 SO 2 \u2014, \u2014OC(O)NR 4 \u2014, \u2014NR 4 C(O)O\u2014, substituted or unsubstituted C 1 -C 3  alkylene, substituted or unsubstituted 2 to 3 membered heteroalkylene; R 2  is independently oxo, halogen, \u2014CX 2 3 , \u2014CHX 2 2 , \u2014CH 2 X 2 , \u2014CN, \u2014SO 2 Cl, \u2014SO n2 R 14 , \u2014SO v2 NR 11 R 12 , \u2014NHNR 11 R 12 , \u2014ONR 11 R 12 , \u2014NHC\u2550(O)NHNR 11 R 12 , \u2014NHC(O)NR 11 R 12 , \u2014N(O) m2 , \u2014NR 11 R 12 , \u2014C(O)R 14 , \u2014C(O)\u2014OR 14 , \u2014C(O)NR 11 R 12 , \u2014OR 15 , \u2014NR 11 SO 2 R 15 , \u2014NR 11 C(O)R 14 , \u2014NR 11 C(O)OR 14 , \u2014NR 11 OR 14 , \u2014OCX 2 3 , \u2014OCHX 2 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; two adjacent R 2  substituents or two R 2  substituents bonded to the same atom may optionally be joined to form a substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl; R 4  is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; R 7 , R 8 , R 9 , R 10 , R 7B , R 8B , R 9B , R 10B , R 11 , R 12 , R 14 , and R 15  are independently hydrogen, halogen, \u2014CX 3 , \u2014CN, \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 2 Cl, \u2014SO 3 H, \u2014SO 4 H, \u2014SO 2 NH 2 , \u2014NHNH 2 , \u2014ONH 2 , \u2014NHC(O)NHNH 2 , \u2014NHC(O)NH 2 , \u2014NHSO 2 H, \u2014NHC(O)H, \u2014NHC(O)OH, \u2014NHOH, \u2014OCX 3 , \u2014OCHX 2 , \u2014CHX 2 , \u2014CH 2 X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 7  and R 8  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R 11  and R 12  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; each X, X 1 , and X 2  is independently \u2014F, \u2014Cl, \u2014Br, or \u2014I; n1, n2, v1, and v2 are independently an integer from 0 to 4; m1 and m2 are independently 1 or 2; z1 is independently an integer from 0 to 5; and z2 is independently an integer from 0 to 10.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 93.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15382942', '15950953', '15757238', '15662861', '15700040']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8593795140496662
- 35 USC 102 Novelty (BERT): 0.5949138892925497
- Combined Prediction Score: 0.8329329515739545
- Mean Citation Score: 535.581868
- Max Citation Score: 593.351
- Similarity Product: 425.33831377005583

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test