PATENT CLAIM ANALYSIS

Application Number: 15919866
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "186100"]

Abstract:
Methods for generating antibodies to immuno-subdominant epitopes of elusive pathogens and vaccines and methods of vaccinating subjects against elusive pathogens are disclosed. The methods include targeting immunodominant B cells to undergo apoptosis, for example, while simultaneously targeting the germinal center (GC) reaction toward preferential selection and differentiation of B cells that produce broadly neutralizing antibody against a targeted pathogen.

Claim (Index 28):
The method of  claim 27 , wherein the inhibitory signal is selected from the group consisting of cyclophosphamide, methotrexate, doxorubicin, aldoxorubicin, cisplatin, a BCL-6 inhibitor, BCL-2 inhibitor, mtor inhibitor, MEK inhibitor, CD22 ligand and FAS ligand.

Metadata:
- Claim Count in Document: 45.0
- Percentile: 90.0
- Lexical Diversity: 1.3
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13989176', '13262285', '14777605', '11962007', '15512820']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8003674425372903
- 35 USC 102 Novelty (BERT): 0.5234862819885965
- Combined Prediction Score: 0.772679326482421
- Mean Citation Score: 315.343366
- Max Citation Score: 333.24872
- Similarity Product: 212.43066106939315

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test