PATENT CLAIM ANALYSIS

Application Number: 16243091
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2020-02
Patent Classification: ["null", "null"]

Abstract:
A method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine is provided. The method comprises the steps of: preparing methyl p-bromophenylacetate (Intermediate I) by catalytic esterification of p-bromophenylacetic acid, and then reacting with dimethyl carbonate to synthesize 2-(4-bromophenyl)-malonic acid-1,3-dimethyl ester (Intermediate 2), cyclizing with formamidine hydrochloride to obtain 5-(4-bromophenyl)-4,6-dihydroxypyrimidine (Intermediate 3), and then chlorinating to give the product 5-(4-bromophenyl)-4,6-dichloropyrimidine. In the process of preparing Intermediate 1 in the present invention, a solid acid is used as a catalyst. Moreover, in the process of preparing Intermediate 2, sodium methoxide is used as a base in place of sodium hydride or sodium amide used in the prior art. Furthermore, Intermediate 3 is prepared by a one-pot process.

Claim (Index 8):
The method for preparing 5-(4-bromophenyl)-4,6-dichloropyrimidine according to  claim 1 , wherein the chlorination in Step 4 comprises:\n Step (1): adding toluene and N,N-dimethylaminopyridine to Intermediate 3, mechanically stirring, adding solid phosgene stepwise at 20-35\u00b0 C., then increasing temperature to 95-105\u00b0 C., reacting for 3-5 hours, and then cooling to 20-30\u00b0 C. for later use; Step (2): mixing water with toluene, cooling to 20-30\u00b0 C. with stirring, and adding to the ready-to-use reaction solution obtained in Step (I), during which the temperature is controlled to 25-35\u00b0 C.; Step (3): stirring for 0.5-1.5 hours at 25-35\u00b0 C., standing for layering, extracting the aqueous phase several times with toluene, and combining the toluene extract and the organic phase; and Step (4): removing the solvent from the combined organic phase obtained in Step (3) under reduced pressure, adding ethanol, stirring for 1-2 hours at 10-20\u00b0 C., filtering under suction, and drying to obtain the product 5-(4-bromophenyl)-4,6-dichloropyrimidine.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 99.0
- Lexical Diversity: 1.95946
- Patent Class: nan
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13521780', '15535413', '15521021', '14399929', '14673427']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5573530483620375
- 35 USC 102 Novelty (BERT): 0.496521173273226
- Combined Prediction Score: 0.5512698608531563
- Mean Citation Score: 222.156194
- Max Citation Score: 235.4971
- Similarity Product: 166.44530393128397

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test