PATENT CLAIM ANALYSIS

Application Number: 15554354
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-06
Patent Classification: ["514", "211060"]

Abstract:
The present invention relates to bicyclic tetrahydrothiazepine of formula (I), wherein R 1  to R 3 , X 1 , X 2  and R 18  have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising such compounds as well as their use as medicaments, especially in methods for the treatment or prevention of a neoplastic and/or infectious disease and in vitro methods.

Claim (Index 28):
A pharmaceutical composition comprising at least one pharmaceutically acceptable carrier and at least one compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein\n X 1  is S; S(O); or S(O) 2 ; \n X 2  is N; or C(R 4 ); \n R 1  is H; or methyl; \n R 2  is phenyl; 3 to 7 membered heterocyclyl; or 7 to 11 membered heterobicyclyl, wherein R 2  is optionally substituted with one or more R 5 , which are the same or different; \n R 5  is halogen; CN; C(O)OR 6 ; OR 6 ; C(O)R 6 ; C(O)N(R 6 R 6a ); S(O) 2 N(R 6 R 6a ); S(O)N(R 6 R 6a ); S(O) 2 R 6 ; S(O)R 6 ; N(R 6 )S(O) 2 N(R 6a R 6b ); SR 6 ; N(R 6 R 6a ); OC(O)R 6 ; N(R 6 )C(O)R 6a ; N(R 6 )S(O) 2 R 6a ; N(R 6 )S(O)R 6a ; N(R 6 )C(O)OR 6a ; N(R 6 )C(O)N(R 6a R 6b ); OC(O)N(R 6 R 6a ); oxo (\u2550O), where the ring is at least partially saturated; T 1 ; C 1-6  alkyl; C 2-6  alkenyl; or C 2-6  alkynyl, wherein C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; \n R 6 , R 6a , and R 6b  are independently selected from the group consisting of H; C 1-6  alkyl, C 2-6  alkenyl; and C 2-6  alkynyl, wherein C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; \n T 1  is phenyl; C 3-7  cycloalkyl; or 3 to 7 membered heterocyclyl, wherein T 1  is optionally substituted with one or more R 7 , which are the same or different; \n R 7  is halogen; CN; C(O)OR 8 ; OR 8 ; C(O)R 8 ; C(O)N(R 8 R 8a ); S(O) 2 N(R 8 R 8a ); S(O)N(R 8 R 8a ); S(O) 2 R 8 ; S(O)R 8 ; N(R 8 )S(O) 2 N(R 8a R 8b ); SR 8 ; N(R 8 R 8a ); OC(O)R 8 ; N(R 8 )C(O)R 8a ; N(R 8 )S(O) 2 R 8a ; N(R 8 )S(O)R 8a ; N(R 8 )C(O)OR 8 a; N(R 8 )C(O)N(R 8a R 8b ); OC(O)N(R 8 R 8a ); oxo (\u2550O), where the ring is at least partially saturated; C 1-6  alkyl; C 2-6  alkenyl; or C 2-6  alkynyl, wherein C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; \n R 8 , R 8a , and R 8b  are independently selected from the group consisting of H; C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl, wherein C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; \n R 3  is R 3a ; OR 3 a; NHR 3 a; or NHC(O)R 3a ; \n R 3a  is T 2 ; C 1-12  alkyl; C 2-12  alkenyl; or C 2-12  alkynyl, wherein C 1-12  alkyl; C 2-12  alkenyl; and C 2-12  alkynyl are optionally substituted with one or more R 9 , which are the same or different; \n R 9  is halogen; CN; C(O)OR 10 ; OR 10 ; C(O)R 10 ; C(O)N(R 10 R 10a ); S(O) 2 N(R 10 R 10a ); S(O)N(R 10 R 10a ); S(O) 2 R 10 ; S(O)R 10 ; N(R 10 )S(O) 2 N(R 10a R 10b ); SR 10 ; N(R 10 R 10a ); OC(O)R 10 ; N(R 10 )C(O)R 10a ; N(R 10 )S(O) 2 R 10a ; N(R 10 )S(O)R 10a ; N(R 10 )C(O)N(R 10a R 10b ); N(R 10 )C(O)OR 10a ; OC(O)N(R 10 R 10a ); T 2 ; C 1-12  alkyl; C 2-12  alkenyl; or C 2-12  alkynyl, wherein C 1-12  alkyl; C 2-12  alkenyl; and C 2-12  alkynyl are optionally substituted with one or more R 11 , which are the same or different; \n R 10 , R 10a , and R 10b  are independently selected from the group consisting of H; T 2 ; C 1-12  alkyl; C 2-12  alkenyl; and C 2-12  alkynyl, wherein C 1-12  alkyl; C 2-12  alkenyl; and C 2-12  alkynyl are optionally substituted with one or more R 11 , which are the same or different; \n T 2  is phenyl; C 3-7  cycloalkyl; 3 to 7 membered heterocyclyl; or 7 to 11 membered heterobicyclyl, wherein T 2  is optionally substituted with one or more R 12 , which are the same or different; \n R 12  is halogen; CN; C(O)OR 13 ; OR 13 ; C(O)R 13 ; C(O)N(R 13 R 13a ); S(O) 2 N(R 13 R 13a ); S(O)N(R 13 R 13a ); S(O) 2 R 13 ; S(O)R 13 ; N(R 13 )S(O) 2 N(R 13a R 13b ); SR 13 ; N(R 13 R 13a ); OC(O)R 13 ; N(R 13 )C(O)R 13a ; N(R 13 )S(O) 2 R 13a ; N(R 13 )S(O)R 13a ; N(R 13 )C(O)OR 13a ; N(R 13 )C(O)N(R 13a R 13b ); OC(O)N(R 13 R 13a ); oxo (\u2550O), where the ring is at least partially saturated; T 3 ; C 1-6  alkyl; C 2-6  alkenyl; or C 2-6  alkynyl, wherein C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more R 14 , which are the same or different; \n R 13 , R 13a , and R 13b  are independently selected from the group consisting of H; C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl, wherein C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more R 14 , which are the same or different; \n R 11  and R 14  are independently selected from the group consisting of halogen; CN; C(O)OR 15 ; OR 15 ; C(O)R 15 ; C(O)N(R 15 R 15a ); S(O) 2 N(R 15 R 15a ); S(O)N(R 15 R 15a ); S(O) 2 R 15 ; S(O)R 15 ; N(R 15 )S(O) 2 N(R 15a R 15b ); SR 15 ; N(R 15 R 15a ); OC(O)R 15 ; N(R 15 )C(O)R 15a ; N(R 15 )S(O) 2 R 15a ; N(R 15 )S(O)R 15a ; N(R 15 )C(O)OR 15 a; N(R 15 )C(O)N(R 15a R 15b ); OC(O)N(R 15 R 15a ); and T 3 ; \n R 15 , R 15a  and R 15b  are independently selected from the group consisting of H; T 3 ; C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl, wherein C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; \n T 3  is phenyl; C 3-7  cycloalkyl; or 3 to 7 membered heterocyclyl, wherein T 3  is optionally substituted with one or more R 16 , which are the same or different; \n R 16  is halogen; CN; C(O)OR 17 ; OR 17 ; C(O)R 17 ; C(O)N(R 17 R 17a ); S(O) 2 N(R 17 R 17a ); S(O)N(R 17 R 17a ); S(O) 2 R 17 ; S(O)R 17 ; N(R 17 )S(O) 2 N(R 17a R 17b ); SR 17 ; N(R 17 R 17a ); OC(O)R 17 ; N(R 17 )C(O)R 17a ; N(R 17 )S(O) 2 R 17a ; N(R 17 )S(O)R 17a ; N(R 17 )C(O)OR 17a ; N(R 17 )C(O)N(R 17a R 17b ); OC(O)N(R 17 R 17a ); oxo (\u2550O), where the ring is at least partially saturated; C 1-6  alkyl; C 2-6  alkenyl; or C 2-6  alkynyl, wherein C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; \n R 17 , R 17a , and R 17b  are independently selected from the group consisting of H; C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl, wherein C 1-6  alkyl; C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more halogen, which are the same or different; \n R 4  is H; F; Cl; or N(CH 3 ) 2 ; \n R 18  is H; C 1-6  alkyl; C 2-6  alkenyl; or C 2-6  alkynyl; wherein C 1-6  alkyl, C 2-6  alkenyl; and C 2-6  alkynyl are optionally substituted with one or more R 19 , which are the same or different; \n R 19  is halogen; CN; C(O)OR 20 ; OR 20 ; C(O)R 20 ; C(O)N(R 20 R 20a ); S(O) 2 N(R 20 R 20a ); S(O)N(R 20 R 20a ); S(O) 2 R 20 ; S(O)R 20 ; N(R 20 )S(O) 2 N(R 20a R 20b ); SR 20 ; N(R 20 R 20a ); NO 2 ; OC(O)R 20 ; N(R 20 )C(O)R 20a ; N(R 20 )SO 2 R 20a ; N(R 20 )S(O)R 20a ; N(R 20 )C(O)N(R 20a R 20b ); N(R 20 )C(O)OR 20 a; or OC(O)N(R 20 R 20a ); and \n R 20 , R 20a , and R 20b  are independently selected from the group consisting of H; and C 1-6  alkyl, wherein C 1-6  alkyl is optionally substituted with one or more halogen, which are the same or different.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.46154
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12295545', '12096393', '13128726', '12096432', '12096439']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7619489129620266
- 35 USC 102 Novelty (BERT): 0.5393239261692945
- Combined Prediction Score: 0.7396864142827535
- Mean Citation Score: 343.96614400000016
- Max Citation Score: 368.7808
- Similarity Product: 295.19794298324587

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test