PATENT CLAIM ANALYSIS

Application Number: 15864305
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "252110"]

Abstract:
The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.

Claim (Index 81):
A prodrug conjugate, having the formula:\n wherein each R 50 , R 51 , R 52 , R 53 , R 54  and R 55  is independently selected from hydrogen, halogen, \u2014OR 10 , \u2014SR 10 , \u2014NR 10 R 11 \u2014, optionally substituted aliphatic, optionally substituted aryl or aryl or optionally substituted heterocyclyl; alternatively, two or more R 50 , R 51 , R 52 , R 53 , R 54  and R 55  together form an optionally substituted ring; each R 100 , R 101 , R 102 , and R 103  are independently selected from absent, hydrogen, halogen, \u2014OR 10 , \u2014SR 10 , \u2014NR 10 R 11 \u2014, optionally substituted aliphatic, optionally substituted aryl or optionally substituted heterocyclyl; alternatively, two R 100 , and R 101  together form an optionally substituted ring;\n h is 3 or 4; \n X 100  is \u2014CH\u2014 or \u2014N\u2014; X 1  is O or S; each R 10  and R 11  is independently selected from absent, hydrogen, halogen, \u2014OR 20 , \u2014SR 20 , \u2014NR 20 R 21 , \u2014C(O)R 20 , \u2014C(O)OR 20 , \u2014C(O)NR 20 R 21 , \u2014N(R 20 )C(O)R 21 , \u2014CF 3 , \u2014CN, \u2014NO 2 , \u2014N 3 , acyl, optionally substituted alkoxy, optionally substituted alkylamino, optionally substituted dialkylamino, optionally substituted alkylthio, optionally substituted alkylsulfonyl, optionally substituted aliphatic, optionally substituted aryl or optionally substituted heterocyclyl; each R 20  and R 21  is selected from hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl; alternatively two R 10  and R 11  together with the atoms to which they are attached may form an optionally substituted 3, 4, 5, 6 or 7 membered carbocyclic or heterocyclyl ring; C1 is a carrier moiety; and, X 2  is selected from direct bond, O, S or NR 20 .

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 1.47561
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14172391', '12823102', '13168497', '14797475', '14034918']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8049127154142189
- 35 USC 102 Novelty (BERT): 0.5152386140567512
- Combined Prediction Score: 0.7759453052784722
- Mean Citation Score: 308.1298940000001
- Max Citation Score: 314.1579
- Similarity Product: 256.38755825697183

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test