PATENT CLAIM ANALYSIS

Application Number: 15907505
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["424", "133100"]

Abstract:
The present application relates to compositions of humanized and humanized/deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One aspect relates to antibodies having one or more modifications in at least one amino acid residue of at least one of the framework regions of the variable heavy chain, the variable light chain or both. Another aspect relates to antibodies which bind endoglin and inhibit angiogenesis. Another aspect relates to the deimmunization of humanized antibodies to reduce immunogenicity. Another aspect relates to the use of humanized and humanized/deimmunized antibodies which bind endoglin for the detection, diagnosis or treatment of a disease or condition associated with endoglin, angiogenesis or a combination thereof.

Claim (Index 19):
A diagnostic method comprising:\n a) providing a sample of cancer cells of a solid tumor or plasma from a patient to be tested; b) detecting in the sample the expression of at least one gene or gene product chosen from a panel of genes or gene products whose expression has been correlated with sensitivity or resistance to an angiogenesis inhibitor, wherein the at least one gene or gene product is chosen from one or more genes or gene products selected from the group consisting of VEGF, VEGF receptor, HIF-1\u03b1, placental growth factor receptor, and CD105; and c) comparing the level of expression of at least one gene or gene product detected in the patient sample to a level of expression of at least one gene or gene product that has been correlated with sensitivity or resistance to the angiogenesis inhibitor.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 88.0
- Lexical Diversity: 2.0
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13485702', '14054446', '15337113', '12751907', '14838006']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8397724565135017
- 35 USC 102 Novelty (BERT): 0.6049336885579935
- Combined Prediction Score: 0.816288579717951
- Mean Citation Score: 697.3074919999997
- Max Citation Score: 742.2861
- Similarity Product: 458.7119936703981

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test