PATENT CLAIM ANALYSIS

Application Number: 15756806
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["435", "006140"]

Abstract:
The present application relates to detection of changes in the number of nucleotides in short homopolymeric nucleic acid repeats, in particular in short homopolymeric microsatellites, for example for the purpose of diagnosing microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency in tumors. Accordingly, methods are provided for detecting changes in the number of nucleotides present in short homopolymeric nucleotide repeat sequences as well as kits and cartridges for automated detection of said changes.

Claim (Index 11):
The method according to  claim 10 , wherein at least the steps of:\n liberating and/or isolating the nucleic acid potentially comprising the target homopolymeric repeat sequence from the source of a nucleic acid; providing said liberated and/or purified nucleic acid potentially comprising the target homopolymeric repeat sequence to the step of generating amplicons; generating amplicons by amplifying a nucleic acid sequence comprising the target homopolymeric repeat sequence; and heating the generated amplicons in the presence of a signal-generating oligonucleotide probe and detecting the changes in the strength of said signal in the function of temperature to obtain at least one melting curve; are performed in a cartridge engageable with said automated system.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.60784
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13860422', '11487156', '14506565', '11576597', '12109775']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5956373862085552
- 35 USC 102 Novelty (BERT): 0.5148030760441217
- Combined Prediction Score: 0.5875539551921118
- Mean Citation Score: 255.72762200000005
- Max Citation Score: 278.07953
- Similarity Product: 158.54897164263602

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test