PATENT CLAIM ANALYSIS

Application Number: 16231177
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-08
Patent Classification: ["514", "265100"]

Abstract:
The present invention relates to compounds of formula I, wherein R 1  is phenyl, lower alkyl, C 3-6 -cycloalkyl, —CH 2 —C 3-6 -cycloalkyl, or bridged C 3-5 -cycloalkyl, optionally substituted by one, two or three substituents, selected from halogen, lower alkyl or lower alkyl substituted by halogen; R 2  is hydrogen, halogen, lower alkoxy, lower alkyl substituted by halogen or lower alkoxy substituted by halogen; R 3  is a five membered heteroaryl group, selected from wherein R 6  is hydrogen or lower alkyl; R 7  is halogen or lower alkyl; R 8  is hydrogen or lower alkyl; R 9  is hydrogen or lower alkyl; R 4  is lower alkyl or lower alkyl substituted by hydroxy; R 5 /R 5′  is independently from each other hydrogen or lower alkyl; ( ) n - is —CH 2 — or —CH 2 CH 2 — for n being 1 or 2; X is CH or N;or to pharmaceutically active acid addition salts thereof, to racemic mixtures or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof.  The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.

Claim (Index 10):
A process for preparing a compound of formula I, which process comprises:\n a) reacting a compound of formula II with a compound of formula III to form a compound of formula I and, optionally, further converting the compounds obtained into pharmaceutically acceptable acid addition salts; or b) reacting a compound of formula V with a compound of formula\n H 2 NR 4  \n to a compound of formula and optionally converting the compounds obtained into pharmaceutically acceptable acid addition salts, and wherein, in a) or b): R 1  is phenyl, lower alkyl, C 3-6 -cycloalkyl, \u2014CH 2 \u2014C 3-6 -cycloalkyl, or bridged C 3-5 -cycloalkyl, any of which are optionally substituted by one, two or three substituents, selected from halogen, lower alkyl, or lower alkyl substituted by halogen; R 2  is hydrogen, halogen, lower alkoxy, lower alkyl substituted by halogen, or lower alkoxy substituted by halogen; R 3  is a five membered heteroaryl group, selected from: wherein R 6  is hydrogen or lower alkyl; R 7  is halogen or lower alkyl; R 8  is hydrogen or lower alkyl; R 9  is hydrogen or lower alkyl; R 4  is lower alkyl or lower alkyl substituted by hydroxy; R 5 /R 5\u2032  is independently from each other hydrogen or lower alkyl; -( ) n - is \u2014CH 2 \u2014 or \u2014CH 2 CH 2 \u2014 for n being 1 or 2; X is CH or N; and Y is halogen.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 98.0
- Lexical Diversity: 2.26667
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16339345', '12845045', '14645033', '13013373', '10480958']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7914910121763845
- 35 USC 102 Novelty (BERT): 0.5492816299024729
- Combined Prediction Score: 0.7672700739489934
- Mean Citation Score: 378.725678
- Max Citation Score: 395.26392
- Similarity Product: 293.538239417038

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test