PATENT CLAIM ANALYSIS

Application Number: 16016917
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-05
Patent Classification: ["544", "328000"]

Abstract:
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Claim (Index 172):
A method of treating influenza infection in a patient comprising administering to said patient an effective amount of a compound of Formula (IA): or a pharmaceutically acceptable salt thereof, wherein:\n Z 1  is \u2014R*, \u2014F, \u2014Cl, \u2014CN, \u2014OR*, \u2014CO 2 R*, \u2014NO 2 , or \u2014CON(R*) 2 ; \n Z 2  is \u2014R*, \u2014OR*, \u2014CO 2 R*, \u2014NR* 2 , or \u2014CON(R*) 2 ; \n Z 3  is \u2014H, \u2014OH, halogen, \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl) 2 , \u2014O(C 1 -C 4  alkyl), or C 1 -C 6  alkyl that is optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, and \u2014O(C 1 -C 4  alkyl); \n R 1  is \u2014H, C 1 -C 6  alkyl, \u2014S(O) 2 -R\u2033, or \u2014C(O)OR\u2033; \n R 2  is \u2014H, \u2014F, \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl) 2 , C\u2550N\u2014OH; cyclopropyl that is optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, \u2014OCH 3 , and \u2014CH 3 ; or \u2014C 1 -C 4  alkyl that is optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, and \u2014O(C 1 -C 4  alkyl); \n R 3  is \u2014H, \u2014CI, \u2014F, \u2014Br, \u2014OH, \u2014O(C 1 -C 4  alkyl), \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl) 2 , \u2014CN, or C 1 -C 4  aliphatic that is optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 C 4  alkyl) 2 , \u2014OCO(C 1 -C 4  alkyl), \u2014CO(C 1 -Ca alkyl), CO 2 H, \u2014CO 2 (C 1 -C 4  alkyl), and C 1 -C 4  alkoxy; \n R 4  is: \n wherein: ring E is a C 4 -C 8  non-aromatic carbocycle optionally further substituted with one or more instances of J A ; ring F is a 4-8 membered non-aromatic heterocycle optionally substituted with one or more instances of J E1 ; each of rings G1 and G2 is independently a 5-10 membered non-aromatic bridged carbocycle optionally substituted with one or more instances of J A ; each J A  is independently selected from the group consisting of halogen, cyano, oxo, \u2014NCO, and Q 1 -R 5 ; or optionally two J A , together with the atom(s) to which they are attached, independently form a 4-8 membered ring that is optionally substituted with one or more instances of J E1 ; Q 1  is independently a bond, \u2014O\u2014, \u2014S\u2014, \u2014NR\u2014, \u2014C(O)\u2014, \u2014C(\u2550NR)\u2014, \u2014CO 2 \u2014, \u2014OC(O)\u2014, \u2014C(O)NR\u2014, \u2014C(O)NRC(O)O\u2014, \u2014NRC(O)NRC(O)O\u2014, \u2014NRC(O)\u2014, \u2014NRC(O)NR\u2014, \u2014NRCO 2 , \u2014OC(O)NR\u2014, \u2014S(O)\u2014, \u2014SO 2 \u2014, \u2014N(R)SO 2 \u2014, \u2014SO 2 NR\u2032\u2014, \u2014NRSO 2 NR\u2032\u2014, or \u2014(CR 6 R 7 ) p \u2014Y 1 \u2014; Q 2  is independently \u2014O\u2014, \u2014CO 2 \u2014, \u2014OC(O)\u2014, \u2014C(O)NR\u2014, \u2014NRC(O)\u2014, \u2014NRC(O)NR\u2014, \u2014NRCO 2 \u2014, \u2014OC(O)NR\u2014, \u2014CO 2 SO 2 \u2014, \u2014P(O) 2 O\u2014, or \u2014(CR 6 R 7 ) p \u2014Y 1 \u2014; Y 1  is independently \u2014O\u2014, \u2014CO 2 \u2014, \u2014OC(O)\u2014, \u2014C(O)NR\u2014, \u2014NRC(O)\u2014, \u2014NRC(O)NR\u2014, \u2014NRCO 2 \u2014, or \u2014OC(O)NR\u2014; R 5  is:\n i) \u2014H, \n ii) an optionally substituted C 1 -C 6  alkyl group, \n iii) an optionally substituted C 3 -C 7  non-aromatic carbocycle, \n iv) an optionally substituted 4-7 membered non-aromatic heterocycle, or \n optionally, together with R and the nitrogen atom to which R is attached, form a 5-7 membered, optionally substituted non-aromatic heterocycle, wherein the alkyl group represented by R 5  is optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl) 2 , \u2014OCO(C 1 -C 4  alkyl), \u2014CO(C 1 -C 4  alkyl), \u2014CO 2 H, \u2014CO 2 (C 1 -C 4  alkyl), C 1 -C 4  alkoxy, an optionally substituted C 3 -C 7  non-aromatic carbocycle, and an optionally substituted 4-7 membered non-aromatic heterocycle; wherein each of said carbocycles and heterocycles represented by R 5  is independently and optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, C 4 -C 4  alkyl, \u2014O(C 1 -C 4  alkyl), \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl) 2 , \u2014C(O)(C 1 -C 4  alkyl), \u2014OC(O)(C 1 -C 4  alkyl), \u2014C(O)O(C 1 -C 4  alkyl) and CO 2 H, wherein each of said alkyl groups is optionally and independently substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl) 2 , \u2014OCO(C 1 -C 4  alkyl), \u2014CO(C 1 -C 4  alkyl), \u2014CO 2 H, \u2014CO 2 (C 1 -C 4  alkyl), and C 1 C 4  alkoxy; \n each of R 8  and R 9  is independently \u2014H, halogen, cyano, hydroxy, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 1 -C 4  hydroxyalkyl, C 2 -C 4  alkoxyalkyl, \u2014O(C 1 -C 4  alkyl), \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), or \u2014N(C 1 -C 4  alkyl) 2 ; R 11 , R 12 , R 13  and R 14  are each independently \u2014H, halogen, or C 1 -C 6  alkyl optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, oxo, hydroxy, oxo, amino, carboxy, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  aminoalkoxy, C 1 -C 6  cyanoalkoxy, C 1 -C 6  hydroxyalkoxy, and C 2 -C 6  alkoxyalkoxy; or optionally, R 13  and R 14 , together with the carbon atom to which they are attached, form a cyclopropane ring, optionally substituted with one or more instances of methyl; R 21 , R 22 , R 23  and R 24  are each independently \u2014H, halogen, \u2014OH, or C 1 -C 6  alkyl optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, oxo, hydroxy, oxo, amino, carboxy, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 C 6  aminoalkoxy, C 1 -C 6  cyanoalkoxy, C 1 -C 6  hydroxyalkoxy, and C 2 -C 6  alkoxyalkoxy; R 6  and R 7  are each independently \u2014H or C 1 -C 6  alkyl optionally substituted with one or more substitutents selected from the group consisting of halogen, cyano, hydroxy, oxo, amino, carboxy, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  aminoalkoxy, C 1 -C 6  cyanoalkoxy, C 1 -C 6  hydroxyalkoxy, and C 2 -C 6  alkoxyalkoxy, or optionally R 6  and R 7 , together with the carbon atom to which they are attached, form a cyclopropane ring optionally substituted with one or more instances of methyl; R and R\u2032 are each independently \u2014H or C 1 -C 6  alkyl optionally and independently substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, amino, carboxy, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  aminoalkoxy, C 1 -C 6  cyanoalkoxy, C 1 -C 6  hydroxyalkoxy, and C 2 -C 6  alkoxyalkoxy; or optionally R\u2032, together with R 5  and the nitrogen atom to which they are attached, form a 5-7 membered non-aromatic heterocycle optionally substituted with one or more instances of J D1 ; each J D1  is independently selected from the group consisting of halogen, cyano, oxo, \u2014R a , \u2014OR b , \u2014SR b , \u2014SOR a , \u2014SO 2 R a , \u2014NHR c , \u2014C(O)R b , \u2014C(O)OR b , \u2014OC(O)R b , \u2014NHC(O)R b , \u2014C(O)NHR c , \u2014NHC(O)NHR c , \u2014NHC(O)OR b , \u2014OCONHR c , \u2014NHC(O)NHC(O)OR b , \u2014N(CH 3 )R c , \u2014N(CH 3 )C(O)R b , \u2014C(O)N(CH 3 )R c , \u2014N(CH 3 )C(O)NHR c , \u2014N(CH 3 )C(O)OR b , \u2014OCON(CH 3 )R c , \u2014C(O)NHCO 2 R b , \u2014C(O)N(CH 3 )CO 2 R b , \u2014N(CH 3 )C(O)NHC(O)OR b , \u2014NHSO 2 R b , \u2014SO 2 NHR b , \u2014SO 2 N(CH 3 )R b , and \u2014N(CH 3 )SO 2 R b ; R\u2033 is independently:\n i) a C 1 -C 6 -alkyl optionally substituted with one or more substituents selected independently from the group consisting of halogen, cyano, hydroxyl, \u2014NH 2 , \u2014NH(C 1 -C 6  alkyl), \u2014N(C 1 -C 6  alkyl) 2 , C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  aminoalkoxy, C 1 -C 6  cyanoalkoxy, C 1 -C 6  hydroxyalkoxy, and C 2 -C 6  alkoxyalkoxy; or \n ii) a C 3 -C 6  carbocyclic group, a 5-6 membered heteroaryl group, or a phenyl group, each optionally and independently being substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, nitro, \u2014NH 2 , \u2014NH(C 1 -C 6  alkyl), \u2014N(C 1 -C 6  alkyl) 2 , C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  cyanoalkyl, C 1 -C 6 -hydroxyalkyl, C 2 -C 6 -alkoxyalkyl, C 1 -C 6 -aminoalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  aminoalkoxy, C 1 -C 6 cyanoalkoxy, C 1 -C 6 -hydroxyalkoxy, and C 2 -C 6  alkoxyalkoxy; \n R* is independently: i)\u2014H; ii) a C 1 -C 6  alkyl group optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, amino, carboxy, C 3 -C 8  non-aromatic carbocycle, 5-6 membered non-aromatic heterocycle, phenyl, 5-6 membered heteroaryl, \u2014O(C 1 -C 6  alkyl), and \u2014C(O)(C 1 -C 6 -alkyl); wherein each of said alkyl groups in \u2014O(C 1 -C 6  alkyl), and \u2014C(O)(C 1 -C 6 -alkyl) is optionally and independently substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl) 2 , \u2014OCO(C 1 -C 4  alkyl), \u2014CO(C 1 -C 4  alkyl), \u2014CO 2 H, \u2014CO 2 (C 1 -C 4  alkyl), and C 1 -C 4  alkoxy; and wherein each of said carbocycle, heterocycle, phenyl, and heteroaryl is independently and optionally substituted with one or more instances of J E1 ; or iii) a C 3 -C 8  non-aromatic carbocycle, or a 4-8 membered non-aromatic heterocycle, each of which is independently and optionally substituted with one or more instances of J E1 ; each J E1  is independently selected from the group consisting of halogen, cyano, hydroxy, oxo, amino, carboxy, amido, C 1 -C 6  alkyl, \u2014O(C 1 -C 6  alkyl), and \u2014C(O)(C 1 -C 6 -alkyl), wherein each of said alkyl groups is optionally and independently substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl) 2 , \u2014OCO(C 1 -C 4  alkyl), \u2014CO(C 1 -C 4  alkyl), CO 2 H, \u2014CO 2 (C 1 -C 4  alkyl), and C 1 -C 4  alkoxy; each R a  is independently:\n i) a C 1 -C 6  aliphatic group optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, amino, carboxy, amido, \u2014O(C 1 -C 6  alkyl), \u2014C(O)(C 1 -C 6 -alkyl), C 3 -C 8  non-aromatic carbocycle, 4-8 membered non-aromatic heterocycle, 5-10 membered heteroaryl group, and 6-10 membered carbocyclic aryl group; wherein each of said alkyl groups for the substituents of the C 1 -C 6  aliphatic group represented by R a  is optionally and independently substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, oxo, \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl) 2 , \u2014OCO(C 1 -C 4  alkyl), \u2014CO(C 1 -C 4  alkyl), \u2014CO 2 H, \u2014CO 2 (C 1 -C 4  alkyl), and C 1 -C 4  alkoxy; and wherein each of said carbocycle, heterocycle, heteroaryl, and carbocyclic aryl groups for the substituents of the C 1 -C 6  aliphatic group represented by R a  is optionally and independently substituted with one or more instances of J E1 ; \n ii) a C 3 -C 8  non-aromatic carbocycle, or a 4-8 membered non-aromatic heterocycle, each of which is optionally and independently substituted with one or more instances of J E1 ; or \n iii) a 5-10 membered heteroaryl, or 6-10 membered carbocyclic aryl group, each of which is optionally and independently substituted with one or more instances of J E1 ; \n R b  and R c  are each independently R a  or \u2014H; or optionally, R b  and R c , together with the nitrogen atom(s) to which they are attached, each independently form a 5-7 membered non-aromatic heterocycle optionally substituted with one or more instances of J E1 ; p and q are each independently 0, 1 or 2; x is 0, 1 or 2; and r is 1 or 2.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 94.0
- Lexical Diversity: 2.60377
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14305393', '15718186', '15299757', '14098867', '14929634']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.862160688821047
- 35 USC 102 Novelty (BERT): 0.6666187144357418
- Combined Prediction Score: 0.8426064913825165
- Mean Citation Score: 651.808932
- Max Citation Score: 787.6186
- Similarity Product: 636.8198647634864

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test