PATENT CLAIM ANALYSIS

Application Number: 15953083
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "178000"]

Abstract:
The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated by NFkB, IL-6, IL-6-R, NADPH oxidase (Nox), and/or superoxide and/or hydrogen peroxide production by a NADPH oxidase, including for example ameliorating, treating, reversing or preventing schizophrenia, psychosis, delirium, e.g., post-operative delirium, drug-induced psychosis, psychotic features associated with frailty syndrome (FS), aging, depression, dementias; traumatic war neurosis, post traumatic stress disorder (PTSD) or post-traumatic stress syndrome (PTSS), Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease), and/or Multiple Sclerosis (MS). The invention also provides methods for purifying a C60 fullerene, C 3  (tris malonic acid C60) or malonic acid derivatives.

Claim (Index 19):
The method of  claim 12 , wherein the C60 malonic acid (propanedioic acid) derivative is purified by a method comprising:\n (i)\n (a) dissolving an impure powder form of a C60 malonic acid derivative in a dilute sodium hydroxide (NaOH) solution at a concentration of between about 1 mM to 400 mM at about 4 degrees C. with stirring, wherein optionally the C60 malonic acid derivative is or comprises a C 3  tris malonic acid C60 fullerene or a C60 macrocyclic malonate derivative, and optionally the malonate is functionalized with a halide atom, or malonate ester groups are replaced by alkyne groups, optionally as a dialkynylmethanofullerene; \n (b) adding a second solution of NaOH more concentrated than the dilute NaOH solution in step (a) drop-wise to the solution of step (a) to achieve an approximately neutral pH; \n (c) incubating the solution of step (b) at 4 degrees C. in the dark for approximately 0.5 to 3 hours; \n (d) centrifuging the solution after the incubating of step \n (c) to produce a clear dark red supernatant and a solid light pink pellet; \n (e) removing the supernatant to a different container; \n (f) incubating the supernatant removed in step (e) at 4 degrees C. for an additional about 3 to 4 hours; and \n (g)\n (1) re-centrifuging to remove substantially all or all undissolved material to generate a pellet and a solution comprising purified C 3  tris malonic acid C60 fullerene, wherein the pellet comprises an insoluble waxy material containing contaminant and small amounts of residual C 3  tris malonic acid C60 fullerene, or \n (2) filtering the sample through a filter which allows only aqueous solutions to pass, thereby removing an insoluble waxy contaminant after solubilization in dilute NaOH, thereby generating a solution comprising purified C 3  tris malonic acid C60 fullerene; or \n \n (ii) the method of (i), wherein the purified C 3  solution is further treated to remove a minor amount of volatile contaminant by vacuum distillation or by bubbling an inert gas through the solution.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 91.0
- Lexical Diversity: 1.81818
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15136787', '12681743', '14358571', '13970639', '14888390']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7354352199522883
- 35 USC 102 Novelty (BERT): 0.6831172510673724
- Combined Prediction Score: 0.7302034230637967
- Mean Citation Score: 411.3179859999999
- Max Citation Score: 801.0581
- Similarity Product: 643.5771280974328

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test