PATENT CLAIM ANALYSIS

Application Number: 15942001
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "157000"]

Abstract:
This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.

Claim (Index 1):
An isolated or recombinant polypeptide comprising the amino acid sequence set forth in SEQ ID NO:1 with up to 50 conservative amino acid substitutions excluding residues 47, 78, 82, 94, 142, 175, 184, 205, 226, 236, 252, 255, 290, 328, and 353 and optionally further excluding residues 464, and 710, wherein if the residue selected from 47, 78, 82, 94, 142, 175, 184, 205, 226, 236, 252, 255, 290, 328, 353, 464, and 710 is substituted the residues have selective substitutions as follows:\n (i) at positions selected from the group consisting of 47, 82, 142, 205, 236, 252, 255, and 464 and any combination thereof, an amino acid residue selected from glycine (G), asparagine (N), glutamine (Q), serine (S), threonine (T), tyrosine (Y), and cysteine (C); (ii) at positions selected from the group consisting of 94, 175, 184, 290 and 353, and any combination thereof, an amino acid residue selected from alanine (A), valine (V), leucine (L), isoleucine (I), proline (P), and methionine (M); (iii) at position 226, an amino acid selected from lysine (K) and arginine (R); (iv) at positions 78 and 328, an amino acid selected from alanine (A), tyrosine (Y), phenylalanine (F), tryptophan (W) and histidine (H); and (v) at position 710 a threonine (T), wherein the polypeptide catalyzes the conversion of a (C 1 -C 12 )alkane to an alcohol.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 90.0
- Lexical Diversity: 1.33333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14788365', '11697404', '14270268', '15224900', '13659144']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6421379861685819
- 35 USC 102 Novelty (BERT): 0.698408487628599
- Combined Prediction Score: 0.6477650363145836
- Mean Citation Score: 629.3445960000001
- Max Citation Score: 743.80457
- Similarity Product: 714.3893112142317

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test