PATENT CLAIM ANALYSIS

Application Number: 15745431
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "04400A"]

Abstract:
Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication, by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting of SNAI2, SOX7 and other factors, the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment, the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention, a method of identifying at least one factor that modulates replication of a virus is also disclosed.

Claim (Index 54):
A method of screening at least one agent for modulating HBV replication, comprising:\n a) contacting a cell expressing the HBV virus with the at least one agent,\n wherein the at least one agent modulates the expression of at least one factor selected from the group consisting of SNAI2, SOX7, HNF4\u03b11, HNF4\u03b12, HNF4\u03b13, HNF4\u03b17, HNF4\u03b18, HNF4\u03b19, ARID3A, ATF2, ATF3, ATF4, CALCOCO1, CHD3, CPD, CSNK2A2, CNOT11, DCP1A, DDX39B, DYRK1B, E2F6, E2F7, EPAS1, FOXN2, HIVEP2, HERPUD1, KPNA3, KANK2, LIN54, LSD1, NCL, PAK1IP1, PNPT1, POLR3E, PRDX3, PTP4A1, RNASEH2A, RHOS, RNF4, RNF43, SERBP1, SKA1, SMAD3, SRPK1, STAM, STRADB, SSB, STT3B, TFAP2A, TFAP2C, TFB2M, TRIM24, TRIM68, TRIM27, WDR54 and ZNF518A; \n b) obtaining a HBV expression profile of the cell contacted with the at least one agent; c) comparing the HBV expression profile of the cell in b) with an HBV expression profile of a control cell that has not been contacted with said at least one agent, wherein a decrease or increase in the expression of the HBV virus in the cell, relative to the control cell, indicates a modulation of HBV replication by said at least one agent.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 86.0
- Lexical Diversity: 1.80952
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15023284', '15268119', '15309680', '14380583', '13037931']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7151166556296625
- 35 USC 102 Novelty (BERT): 0.5044681698832428
- Combined Prediction Score: 0.6940518070550206
- Mean Citation Score: 205.083358
- Max Citation Score: 234.54459
- Similarity Product: 152.2558121597081

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test