PATENT CLAIM ANALYSIS

Application Number: 15864305
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "252110"]

Abstract:
The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.

Claim (Index 82):
A prodrug conjugate having the formula: wherein n is selected from 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 and 30; each R 10  and R 11  is independently selected from hydrogen, halogen, \u2014OR 20 , \u2014SR 20 , \u2014NR 20 R 21 , \u2014C(O)R 20 , \u2014C(O)OR 20 , \u2014C(O)NR 20 R 21 , \u2014N(R 20 )C(O)R 21 , \u2014CF 3 , \u2014CN, \u2014NO 2 , \u2014N 3 , acyl, optionally substituted alkoxy, optionally substituted alkylamino, optionally substituted dialkylamino, optionally substituted alkylthio, optionally substituted alkylsulfonyl, optionally substituted aliphatic, optionally substituted aryl or optionally substituted heterocyclyl; alternatively two R 10  and R 11  together with the atoms to which they are attached may form an optionally substituted 3, 4, 5, 6 or 7 membered carbocyclic or heterocyclyl ring; X 1  is O or S; and X 2  is selected from direct bond, O, S or NR 20 ; wherein each R 20  and R 21  is selected from hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 1.47561
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14172391', '12823102', '13168497', '14797475', '14034918']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8046926651318624
- 35 USC 102 Novelty (BERT): 0.518552613605095
- Combined Prediction Score: 0.7760786599791858
- Mean Citation Score: 308.1298940000001
- Max Citation Score: 314.1579
- Similarity Product: 233.1576249133587

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test