PATENT CLAIM ANALYSIS

Application Number: 16168503
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["424", "133100"]

Abstract:
The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

Claim (Index 1):
An isolated antibody that specifically binds HtrA1, or an antigen-binding fragment thereof, wherein the antibody comprises a binding domain comprising the following six hypervariable regions (HVRs):\n (a) an HVR-H1 comprising the amino acid sequence of DSEX 1 H (SEQ ID NO: 1), wherein X 1  is Met or Leu; (b) an HVR-H2 comprising the amino acid sequence of GVDPETX 2 GAAYNQKFKG (SEQ ID NO: 2), wherein X 2  is Glu or Asp; (c) an HVR-H3 comprising the amino acid sequence of GYDYDYALDY (SEQ ID NO: 3); (d) an HVR-L1 comprising the amino acid sequence of RASSSVX 3 FIH (SEQ ID NO: 4), wherein X 3  is Glu or Asn; (e) an HVR-L2 comprising the amino acid sequence of ATSX 4 LAS (SEQ ID NO: 5), wherein X 4  is Asn, His or Glu; and (f) an HVR-L3 comprising the amino acid sequence of QQWX 5 SX 6 PWT (SEQ ID NO: 6), wherein X 5  is Ser or Tyr and X 6  is Ala or Asn.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.33333
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15336171', '14937778', '15274612', '13651289', '15895741']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7624986865240296
- 35 USC 102 Novelty (BERT): 0.6495409811445478
- Combined Prediction Score: 0.7512029159860815
- Mean Citation Score: 522.1880259999998
- Max Citation Score: 684.88605
- Similarity Product: 624.95939422414

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test