PATENT CLAIM ANALYSIS

Application Number: 15914587
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "450000"]

Abstract:
Provided are a pharmaceutical composition of an amorphous vortioxetine or a salt thereof, and a preparation method therefor. The pharmaceutical composition comprises an amorphous vortioxetine or a pharmaceutically acceptable salt thereof and two or more pharmaceutical excipients. The pharmaceutical composition has good stability and dispersity, and enhances the dissolution of vortioxetine or the pharmaceutically acceptable salt thereof, thereby improving the bioavailability of the medicinal formulation and the body absorption of the medicine.

Claim (Index 13):
A method for preparing a pharmaceutical composition of  claim 1 , comprising the following steps:\n 1) mixing vortioxetine or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable excipients in a solvent, at a temperature of \u221250 to 150\u00b0 C., to form a solution or suspension containing vortioxetine or the pharmaceutically acceptable salt and the pharmaceutical excipients, wherein the weight ratio of vortioxetine or its pharmaceutically acceptable salt to the solvent is 0.001\u02dc100:1, and the weight ratio of vortioxetine or its pharmaceutically acceptable salt to the total pharmaceutically acceptable excipients is 1:0.1\u02dc100; and 2) removing the solvent in the solution or suspension obtained in step 1) to obtain the composition of amorphous vortioxetine or pharmaceutically acceptable salt thereof and the pharmaceutical excipients.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 90.0
- Lexical Diversity: 1.95
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14916075', '15304929', '14429388', '15048868', '14902326']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7628782074390753
- 35 USC 102 Novelty (BERT): 0.5378022820967931
- Combined Prediction Score: 0.7403706149048471
- Mean Citation Score: 348.08949
- Max Citation Score: 392.5238
- Similarity Product: 265.98981261882784

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test