PATENT CLAIM ANALYSIS

Application Number: 16329399
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-07
Patent Classification: ["514", "092000"]

Abstract:
Disclosed are compounds of Formula (I), Formula (II), Formula (III), and Formula (IV) or salts thereof, wherein R 2  is —OH or —OP(O)(OH) 2 ; and R 1  is defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P 1 , and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Claim (Index 2):
The compound according to  claim 1  wherein said compound is selected from: (1R,3S)-1-amino-3-(2-heptyl-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl) methanol, TFA salt (1); ((1R,3S)-1-amino-3-(2-propyl-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (2); ((1R,3S)-1-amino-3-(2-(3,3-dimethylbutyl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (3); ((1R,3S)-1-amino-3-(2-neopentyl-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (4); ((1R,3S)-1-amino-3-(2-hexyl-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (5); ((1R,3S)-1-amino-3-(2-butyl-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl) methanol, trifluoroacetic acid salt (6); ((1R,3S)-1-amino-3-(2-(2-butoxyethoxy)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl) cyclopentyl)methanol, trifluoroacetic acid salt (7); ((1R,3S)-1-amino-3-(2-butoxy-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl) methanol, trifluoroacetic acid salt (8); ((1R,3S)-1-amino-3-(2-(hexyloxy)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (9); ((1R,3S)-1-amino-3-(2-(butylthio)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl) methanol, trifluoroacetic acid salt (10); ((1R,3S)-1-amino-3-(2-(pentylthio)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (11); ((1R,3S)-1-amino-3-(2-(pentyloxy)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl) methanol, trifluoroacetic acid salt (12); ((1R,3S)-1-amino-3-(2-(hexyloxy)naphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (13); ((1R,3S)-1-amino-3-(2-(butylthio)naphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (14); ((1R,3S)-1-amino-3-(2-(pentyloxy)naphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (15); ((1R,3S)-1-amino-3-(2-butoxynaphtho[2,1-d]thiazol-7-yl) cyclopentyl)methanol, trifluoroacetic acid salt (16); ((1R,3S)-1-amino-3-(2-(butylamino)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (17); ((1R,3S)-1-amino-3-(2-(butyl(methyl)amino)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (18); ((1R,3S)-1-amino-3-(2-(p-tolyl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methanol, trifluoroacetic acid salt (19); ((1R,3S)-1-amino-3-(2-(3-methoxyphenyl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl) cyclopentyl)methanol, trifluoroacetic acid salt (20); ((1R,3S)-1-amino-3-(2-pentyl-4,5-dihydronaphtho[2,1-b]thiophen-7-yl) cyclopentyl)methanol, trifluoroacetic acid salt (21); ((1R,3S)-1-amino-3-(2-(hexyloxy)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl) methyl dihydrogen phosphate, trifluoroacetic acid salt (30); ((1R,3S)-1-amino-3-(2-(butylthio)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (31); ((1R,3S)-1-amino-3-(2-(butylamino)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (32); ((1R,3S)-1-amino-3-(2-(pentylthio)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (33); ((1R,3S)-1-amino-3-(2-(pentyloxy)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl) cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (34); ((1R,3S)-1-amino-3-(2-(p-tolyl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (35); ((1R,3S)-1-amino-3-(2-(3-methoxyphenyl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (36); ((1R,3S)-1-amino-3-(2-(3,3-dimethylbutyl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (37); ((1R,3S)-1-amino-3-(2-neopentyl-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (38); ((1R,3S)-1-amino-3-(2-butyl-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (39); ((1R,3S)-1-amino-3-(2-hexyl-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, trifluoroacetic acid salt (40); ((1R,3S)-1-amino-3-(2-butoxynaphtho[2,1-d]thiazol-7-yl) cyclopentyl)methyl dihydrogen phosphate, TFA salt (46); ((1R,3S)-1-amino-3-(2-(hexyloxy)naphtho[2,1-d]thiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate, TFA salt (47); and ((1R,3S)-1-amino-3-(2-(butylthio)naphtho[2,1-d]thiazol-7-yl)cyclopentyl) methyl dihydrogen phosphate (48).

Metadata:
- Claim Count in Document: 3.0
- Percentile: 99.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13504541', '13811032', '13883358', '13145730', '15337843']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8053709017551476
- 35 USC 102 Novelty (BERT): 0.573121767635381
- Combined Prediction Score: 0.782145988343171
- Mean Citation Score: 364.75398
- Max Citation Score: 498.36066
- Similarity Product: 366.0031256163418

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test