PATENT CLAIM ANALYSIS

Application Number: 16179177
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["435", "007100"]

Abstract:
A multiphoton fluorescence anisotropy microscopy live cell imaging system and method to measure and map drug-target interaction in real time at subcellular resolution. Proposed modality enables a direct measurement of drug/target binding in vivo, high-resolution spatial and temporal mapping of bound and unbound drug distribution, and presents an versatile tool to enhance understanding of drug activity. Application of the system to measurement of intracellular target engagement of the chemotherapeutic Olaparib, a poly(ADP-ribose) polymerase inhibitor, in live cells and within a tumor in vivo.

Claim (Index 5):
A method for a spatially-resolved optical detection of binding between a compound and a target, the method comprising:\n optically imaging a combination of the a fluorescently labeled compound in the presence of the target to form an image representing a degree of anisotropy of light emitted by the combination; and distinguishing a first portion of the target from a second portion of the target based on said image, the first portion being devoid of a target-bound compound, the second portion having the compound bound thereto.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 98.0
- Lexical Diversity: 1.43077
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11173814', '13369902', '13504112', '15581386', '16147370']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5409386317390755
- 35 USC 102 Novelty (BERT): 0.490501352839682
- Combined Prediction Score: 0.5358949038491362
- Mean Citation Score: 198.94689
- Max Citation Score: 219.01436
- Similarity Product: 165.78968646881106

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test