PATENT CLAIM ANALYSIS

Application Number: 15769065
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["544", "242000"]

Abstract:
The invention relates to a salt, a hydrate or a crystalline form of an EGFR inhibitor, and use thereof. Specifically it relates to 4-[(3-chloro-4-fluorophenyl) amino]-7-methoxy-6-[3-[(1R,6S)-2,5-dioxa-8-azabicyclo [4.3.0] nonan-8-yl] propoxy]quinazoline dimethanesulfonate, hydrate and a crystalline form thereof; the invention also relates to a preparation method of the crystalline form disclosed herein, a pharmaceutical composition containing the crystalline form, and uses thereof for treating proliferative disorders.

Claim (Index 4):
A crystalline form of a monohydrate of a compound having formula (I): wherein the crystalline form is form I having one or more of following characteristics: i) an X-ray powder diffraction (XRPD) pattern comprising peaks expressed in degrees 2\u03b8 at 14.88\u00b0\u00b10.2\u00b0, 18.05\u00b0\u00b10.2\u00b0, 20.84\u00b0\u00b10.2\u00b0, 21.34\u00b0\u00b10.2\u00b0, 24.39\u00b0\u00b10.2\u00b0 and 25.18\u00b0\u00b10.2\u00b0; or/and ii) the following structure parameters analyzed from monocrystalline:\n Crystallographic System: monoclinic system \n Space Groups: C2/c; \n Cell Parameters: a=27.3004(5) \u212b, \u03b1=90\u00b0,\n b=16.2882(3) \u212b, \u03b2=103.3439(17)\u00b0, \n c=14.3529(2) \u212b, \u03b3=90\u00b0; \n \n Volume: 6210.01(18) \u212b 3 ; \n Molecules number of \n each unit cell (Z): 8.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 91.0
- Lexical Diversity: 1.71154
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13003216', '15314938', '15778220', '14896992', '15539147']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7565184510167459
- 35 USC 102 Novelty (BERT): 0.4751432147402509
- Combined Prediction Score: 0.7283809273890964
- Mean Citation Score: 210.23572400000003
- Max Citation Score: 218.16515
- Similarity Product: 179.09273891977367

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test