PATENT CLAIM ANALYSIS

Application Number: 15902769
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "093480"]

Abstract:
Methods using chemotherapy drugs promote targeting of  S. typhimurium  A1-R of melanoma, thereby enhancing efficacy against the melanoma PDOX. A metastatic melanoma obtained from the right chest wall of a patient was previously established orthotopically in the right chest wall of nude mice as a patient-derived orthotopic xenograft (PDOX) model. We previously showed that the combination of tumor targeting  Salmonella typhimurium  A1-R ( S. typhimurium  A1-R) and chemotherapy was highly effective against the melanoma PDOX. In the present study, we investigated the mechanism of the high efficacy of this combination. Combination therapy significantly increases  S. typhimurium  A1-R tumor targeting alone ( S. typhimurium  A1-R+TEM: p<0.01,  S. typhimurium  A1-R+VEM: p<0.01).

Claim (Index 9):
The method of  claim 1 , wherein the tumor is an adenocarcinoma.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 88.0
- Lexical Diversity: 1.81429
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11330017', '13871716', '15482170', '10301517', '14065284']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6605323877714618
- 35 USC 102 Novelty (BERT): 0.500357784667482
- Combined Prediction Score: 0.6445149274610639
- Mean Citation Score: 116.9285192
- Max Citation Score: 126.126526
- Similarity Product: 69.69317631729317

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test