PATENT CLAIM ANALYSIS

Application Number: 15872791
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "006100"]

Abstract:
Disclosed is nucleic acid preserving compositions and methods of manufacturing and using the same. Compositions include a carrier, a chaotropic agent, a buffering agent, a chelating agent, a surfactant, an alcohol, an acid, and a mucolytic agent. Compositions as aqueous solutions can include water as a carrier. Preferred embodiments include water, guanidine thiocyanate, Tris, EDTA, SLS, SDA 3C, HCl, and N-acetyl-L-cysteine. Some embodiments include a colored dye as a visual indicator. Methods of manufacturing include combining the components into a mixture, such as an aqueous solution. Methods of use include providing a biological sample that includes nucleic acid and contacting the biological sample with the composition. Kits include the composition disposed in a portion of a biological sample collection apparatus.

Claim (Index 15):
The composition of  claim 9 , wherein the composition:\n (i) is substantially free or devoid of a, additional, or any mucolytic agent besides or other than N-acetyl-L-cysteine; (ii) is substantially free or devoid of additional or any antimicrobial agent(s), bactericidal agent(s), and/or bacteriostatic agent(s) besides or other than the alcohol(s), chaotropic agent(s), surfactant(s)/detergent(s), and/or mucolytic agent(s); (iii) is substantially free or devoid of additional or any ribonuclease inhibitor(s) or inhibitor(s) of ribonuclease besides or other than the chaotropic agent(s), the composition preferably substantially devoid of heparin, heparan sulfate, oligo (vinylsulfonic acid), poly(vinylsulfonic acid), oligo(vinylphosphonic acid), and/or poly(vinylsulfonic acid), or salt(s) thereof); (iv) is substantially free or devoid of a or any protease(s); (v) is substantially free or devoid of ascorbic acid, dithionite, erythiorbate, dithiothreitol, 2-mercaptoethanol, dierythritol, a resin-supported thiol, a resin-supported phosphine, vitamin E, and/or trolox, or salt(s) thereof; (vi) is substantially free or devoid of microbe(s) and/or microbial contamination; and/or (vii) has less than or equal to about 100, 99, 98, 97, 96, 95, 90, 85, 80, 75, 70, 65, 60, 55, 50, 45, 40, 35, 30, 25, 20, 15, 10, or 5 colony forming units (cfu) of the one or more microbes per gram of the composition (cfu/g).

Metadata:
- Claim Count in Document: 18.0
- Percentile: 86.0
- Lexical Diversity: 2.04286
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14422979', '14431243', '14238625', '12718713', '13524560']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5491483626048009
- 35 USC 102 Novelty (BERT): 0.5121633157818822
- Combined Prediction Score: 0.5454498579225091
- Mean Citation Score: 173.69106399999995
- Max Citation Score: 183.26277
- Similarity Product: 101.02206920331716

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test