PATENT CLAIM ANALYSIS

Application Number: 16057954
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["424", "499000"]

Abstract:
Systems and methods for targeting specific cancer cell subpopulations present in tumor tissue are described. A system can include a first component for specifically targeting cancer stem cells and a second component for specifically targeting differentiated cancer cells. A system can include a drug conjugated to small (e.g., 5-20 nm) nanoparticles, e.g., polyhedral oligomeric silsequioxane nanoparticles. The small nanoparticles can be preferentially taken up by cancer stem cells via macropinocytosis and can release a toxic payload within the cancer stem cells without triggering the efflux pump. A system can include a second component that targets differentiated cancer cells, e.g., a free drug or a drug encapsulated in nanoparticles.

Claim (Index 15):
The method of  claim 14 , the method further comprising delivering a second biologically active agent to the area, wherein the second biologically active agent is configured to effect the differentiated cancer cells.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 96.0
- Lexical Diversity: 1.875
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15616103', '14527028', '13984411', '14408748', '14950033']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6843807456954597
- 35 USC 102 Novelty (BERT): 0.5117516678545659
- Combined Prediction Score: 0.6671178379113704
- Mean Citation Score: 248.608056
- Max Citation Score: 253.87616
- Similarity Product: 170.37329998199462

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test