PATENT CLAIM ANALYSIS

Application Number: 15946601
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["548", "240000"]

Abstract:
Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M 1  is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR 11  or NR 12 R 13 , and R 11 , R 12  and R 13  are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.

Claim (Index 10):
The method of  claim 1  wherein\n Z is phenyl optionally substituted with up to 5 substituents independently selected from R 2 ; \n Q is phenyl or 1-naphthalenyl, each optionally substituted with up to four substituents independently selected from R 3 ; \n each R 2  is independently halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkylthio, C 1 -C 6  haloalkylthio, C 1 -C 6  alkylamino, C 2 -C 6  dialkylamino, \u2014CN or \u2014NO 2 ; \n each R 3  is independently halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, C 2 -C 6  haloalkenyl, C 2 -C 6  alkynyl, C 3 -C 6  haloalkynyl, C 3 -C 6  cycloalkyl, C 3 -C 6  halocycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkylthio, C 2 -C 7  alkylcarbonyl, C 2 -C 7  haloalkylcarbonyl, C 1 -C 6  haloalkylthio, C 1 -C 6  alkylsulfinyl, C 1 -C 6  haloalkylsulfinyl, C 1 -C 6  alkylsulfonyl, C 1 -C 6  haloalkylsulfonyl, \u2014N(R 4 )R 5 , \u2014C(\u2550W)N(R 4 )R 5 , \u2014C(\u2550W)OR 5 , \u2014CN, \u2014OR 11  or \u2014NO 2 ; or a phenyl ring or a 5- or 6-membered saturated or unsaturated heterocyclic ring, each ring optionally substituted with one or more substituents independently selected from halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  halocycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkylthio, C 1 -C 6  haloalkylthio, C 1 -C 6  alkylsulfinyl, C 1 -C 6  haloalkylsulfinyl, C 1 -C 6  alkylsulfonyl, C 1 -C 6  haloalkylsulfonyl, \u2014CN, \u2014NO 2 , \u2014N(R 4 )R 5 , \u2014C(\u2550W)N(R 4 )R 5 , \u2014C(\u2550O)OR 5  and R 7 ; \n each R 4  is independently H, C 1 -C 6  alkyl, C 1 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 4 -C 7  alkylcycloalkyl, C 4 -C 7  cycloalkylalkyl, C 2 -C 7  alkylcarbonyl or C 2 -C 7  alkoxycarbonyl; \n each R 5  is independently H; or C 1 -C 6  alkyl, C 1 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  cycloalkyl, C 4 -C 7  alkylcycloalkyl or C 4 -C 7  cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R 6 ; \n each R 6  is independently halogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 1 -C 6  alkylthio, C 1 -C 6  alkylsulfinyl, C 1 -C 6  alkylsulfonyl, C 1 -C 6  alkylamino, C 2 -C 8  dialkylamino, C 3 -C 6  cycloalkylamino, C 2 -C 7  alkylcarbonyl, C 2 -C 7  alkoxycarbonyl, C 2 -C 7  alkylaminocarbonyl, C 3 -C 9  dialkylaminocarbonyl, C 2 -C 7  haloalkylcarbonyl, C 2 -C 7  haloalkoxycarbonyl, C 2 -C 7  haloalkylaminocarbonyl, C 3 -C 9  halodialkylaminocarbonyl, \u2014OH, \u2014NH 2 , \u2014CN or \u2014NO 2 ; or Q 1 ; \n each R 7  is independently a phenyl ring or a pyridinyl ring, each ring optionally substituted with one or more substituents independently selected from R 8 ; \n each R 8  is independently halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkylthio, C 1 -C 6  haloalkylthio, C 1 -C 6  alkylsulfinyl, C 1 -C 6  haloalkylsulfinyl, C 1 -C 6  alkylsulfonyl, C 1 -C 6  haloalkylsulfonyl, C 1 -C 6  alkylamino, C 1 -C 6  dialkylamino, C 2 -C 4  alkylcarbonyl, C 2 -C 4  alkoxycarbonyl, C 2 -C 7  alkylaminocarbonyl, C 3 -C 7  dialkylaminocarbonyl, \u2014OH, \u2014NH 2 , \u2014C(\u2550O)OH, \u2014CN or \u2014NO 2 ; \n each Q 1  is independently a phenyl ring or a 5- or 6-membered saturated or unsaturated heterocyclic ring, each ring optionally substituted with one or more substituents independently selected from halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  halocycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkylthio, C 1 -C 6  haloalkylthio, C 1 -C 6  alkylsulfinyl, C 1 -C 6  haloalkylsulfinyl, C 1 -C 6  alkylsulfonyl, C 1 -C 6  haloalkylsulfonyl, C 1 -C 6  alkylamino, C 2 -C 6  dialkylamino, \u2014CN, \u2014NO 2 , \u2014C(\u2550W)N(R 9 )R 10  and \u2014C(\u2550O)OR 10 ; \n each R 9  is independently H, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 4 -C 7  alkylcycloalkyl, C 4 -C 7  cycloalkylalkyl, C 2 -C 7  alkylcarbonyl or C 2 -C 7  alkoxycarbonyl; \n each R 10  is independently H; or C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 4 -C 7  alkylcycloalkyl or C 4 -C 7  cycloalkylalkyl; \n each R 11  is independently H; or C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 4 -C 7  alkylcycloalkyl, C 4 -C 7  cycloalkylalkyl, C 2 -C 7  alkylcarbonyl, C 2 -C 7  alkoxycarbonyl, C 1 -C 6  alkylsulfonyl or C 1 -C 6  haloalkylsulfonyl; and \n each W is independently O or S.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 91.0
- Lexical Diversity: 2.5534
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12933493', '15159322', '14683423', '12679382', '13544113']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8699261230191285
- 35 USC 102 Novelty (BERT): 0.5734737310739446
- Combined Prediction Score: 0.8402808838246102
- Mean Citation Score: 422.608154
- Max Citation Score: 456.38446
- Similarity Product: 451.3000973581159

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test