PATENT CLAIM ANALYSIS

Application Number: 16124846
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["544", "238000"]

Abstract:
Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

Claim (Index 66):
A method of treating a subject suffering from or susceptible to a metalloenzyme-related disorder or disease, comprising administering to the subject an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof; wherein\n A is N or CR 5 ; \n W is N or CR 6 ; \n X is N or CR 6 ; \n Y is N or CR 6 ; \n Z is N or CR 6 ; \n provided that no more than two of W, X, Y, and Z are N; \n R 1  is hydrogen, halogen, cyano, acyl, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, cycloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, NR a R b , NHSO 2 R c , CH 2 NR a R b , CR e R f NHSO 2 R d , OR f , SR f , CO 2 R e , COR f , S(O)R d , S(O) 2 R d , CH 2 OR f , or CR e R f OH, wherein any R 1  can be optionally substituted with 1-3 independent substituents R 7 ; \n R 2  is hydrogen, halogen, cyano, alkyl, or haloalkyl; \n or R 1  and R 2  together with the atoms to which they are attached form an aryl, heterocycloalkyl, or cycloalkyl ring; \n R 3  is hydrogen, halogen, cyano, acyl, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, cycloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, NR a R b , NHSO 2 R c , CH 2 NR a R b , CH 2 NHSO 2 R d , CO 2 R e , COR f , CH 2 OR f , or CR e R f OH; \n R 4  is alkyl, cycloalkyl, haloalkyl, or heteroalkyl; \n R 5  is hydrogen, cyano, alkyl, haloalkyl, heteroalkyl, or cycloalkyl; \n each occurrence of R 6  is, independently, hydrogen, halogen, cyano, haloalkyl, alkyl, cycloalkyl, alkoxy, haloalkyl, OR f , or carboxyl; \n each occurrence of R 7  is, independently, halogen, alkyl, alkoxy, haloalkyl, carboxyl, cycloalkyl, aryl, aryl substituted with 1-3 independent halogen, \u2014(CH 2 ) n C(O)NR g R h , \u2014S(O) 2 R i , \u2014CO 2 R j , or NR g R h ; \n each n is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; \n each occurrence of R a , R b , R c , R d , R e , and R f  is, independently, hydrogen, acyl, alkoxyalkyl, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C(O)OC 1-6  alkyl, C(O)C 1-6  alkyl, a nitrogen protecting group when attached to a nitrogen atom, or an oxygen protecting group when attached to an oxygen atom; or R a  and R b  together with the atoms to which they are attached form a heterocycloalkyl ring; or R e  and R f  together with the atoms to which they are attached form a cycloalkyl ring; and \n each occurrence of R g , R h , R i , and R j  is, independently, hydrogen, acyl, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C(O)OC 1-6  alkyl, C(O)C 1-6  alkyl, or R g  and R h  together with the atoms to which they are attached form a heterocycloalkyl ring.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 97.0
- Lexical Diversity: 1.04545
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15857950', '15858015', '14776280', '13651312', '14580045']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7770673907172623
- 35 USC 102 Novelty (BERT): 0.6203221782784852
- Combined Prediction Score: 0.7613928694733846
- Mean Citation Score: 449.73928000000006
- Max Citation Score: 604.79395
- Similarity Product: 504.1656360998512

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test