PATENT CLAIM ANALYSIS

Application Number: 16129458
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "311000"]

Abstract:
The invention discloses compounds of Formula (I), wherein A 1 , R 1 , R 2 , R 3 , R 4 , and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Claim (Index 1):
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein\n A 1  is selected from the group consisting of C 3 -C 7  cycloalkyl, C 4 -C 7  cycloalkenyl, and 4-7 membered heterocyclyl; \n R 1  is selected from the group consisting of 6-10 membered aryl, 5-11 membered heteroaryl, C 3 -C 11  cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl; wherein the R 1  6-10 membered aryl, 5-11 membered heteroaryl, C 3 -C 11  cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl are substituted with two or more substituents independently selected from the group consisting of R 7 , OR 7 , SR 7 , C(O)R 7 , OC(O)R 7 , C(O)OR 7 , SO 2 R 7 , C(O)NH 2 , C(O)NHR 7 , C(O)N(R 7 ) 2 , NHC(O)R 7 , NHR 7 , N(R 7 ) 2 , NH 2 , C(O)OH, OH, oxo, CN, NO 2 , F, Cl, Br and I; \n R 2  is independently selected from the group consisting of R 8 , OR 8 , C(O)R 8 , C(O)OR 8 , SO 2 R 8 , NHR 8 , N(R 8 ) 2 , NH 2 , C(O)OH, OH, CN, NO 2 , F, Cl, Br and I; \n n is 0 or 1; \n R 3  is selected from the group consisting of C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, 6-10 membered aryl, 5-11 membered heteroaryl, C 3 -C 11  cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl; wherein the R 3  C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 6  alkoxy, phenyl, OH, oxo, CN, NO 2 , F, Cl, Br and I; wherein the R 3  6-10 membered aryl, 5-11 membered heteroaryl, C 3 -C 11  cycloalkyl, C 4 -C 11 cycloalkenyl, and 4-12 membered heterocyclyl are optionally substituted with one or more substituents independently selected from the group consisting of R 9 , OR 9 , SR 9 , C(O)R 9 , OC(O)R 9 , C(O)OR 9 , SO 2 R 9 , C(O)NH 2 , C(O)NHR 9 , C(O)N(R 9 ) 2 , NHC(O)R 9 , NHR 9 , N(R 9 ) 2 , NH 2 , C(O)OH, OH, oxo, CN, NO 2 , F, Cl, Br and I; \n R 4  is selected from the group consisting of hydrogen and C 1 -C 6  alkyl; wherein the R 4  C 1 -C 6  alkyl is optionally substituted with one or more substituents independently selected from the group consisting of OR 10 , F, Cl, Br and I; \n R 7 , at each occurrence, is independently selected from the group consisting of C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, 6-10 membered aryl, 5-11 membered heteroaryl, C 3 -C 11 cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl; wherein each R 7  C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 6  alkoxy, C 3 -C 7  cycloalkyl, OH, oxo, CN, NO 2 , F, Cl, Br and I; wherein each R 7  6-10 membered aryl, 5-11 membered heteroaryl, C 3 -C 11  cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl is optionally substituted with one or more substituents independently selected from the group consisting of R 11 , OR 11 , SR 11 , C(O)R 11 , OC(O)R 11 , C(O)OR 11 , SO 2 R 11 , C(O)NH 2 , C(O)NHR 11 , C(O)N(R 11 ) 2 , NHC(O)R 11 , NHR 11 , N(R 11 ) 2 , NH 2 , C(O)OH, OH, oxo, CN, NO 2 , F, Cl, Br and I; \n R 8 , at each occurrence, is independently selected from the group consisting of C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl; wherein each R 8  C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of R 12 , OR 12 , C(O)OR 12 , NHR 12 , N(R 12 ) 2 , NH 2 , C(O)OH, OH, CN, NO 2 , F, Cl, Br and I; \n R 9 , at each occurrence, is independently selected from the group consisting of C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, 6-10 membered aryl, 5-11 membered heteroaryl, C 3 -C 11 cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl; wherein each R 9  C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of R 13 , OR 13 , SR 13 , C(O)R 3 , OC(O)R 13 , C(O)OR 13 , SO 2 R 13 , C(O)NH 2 , C(O)NHR 13 , C(O)N(R 13 ) 2 , NHC(O)R 13 , NHR 13 , N(R 13 ) 2 , NH 2 , C(O)OH, OH, oxo, CN, NO 2 , F, Cl, Br and I; wherein each R 9  6-10 membered aryl, 5-11 membered heteroaryl, C 3 -C 11  cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl is optionally substituted with one or more substituents independently selected from the group consisting of R 14 , OR 14 , SR 14 , C(O)R 14 , OC(O)R 14 , C(O)OR 14 , SO 2 R 14 , C(O)NH 2 , C(O)NHR 14 , C(O)N(R 14 ) 2 , NHC(O)R 14 , NHR 14 , N(R 14 ) 2 , NH 2 , C(O)OH, OH, oxo, CN, NO 2 , F, Cl, Br and I; \n R 10 , at each occurrence, is independently C 1 -C 4  alkyl; \n R 11 , at each occurrence, is independently selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 6 -C 10  membered aryl, C 3 -C 11  cycloalkyl, 4-12 membered heterocyclyl, C 4 -C 11  cycloalkenyl, and 5-6 membered heteroaryl; wherein each R 11  C 1 -C 6  alkyl and C 1 -C 6  alkoxy is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 6  alkoxy, OH, oxo, CN, NO 2 , F, Cl, Br and I; wherein each R 11  C 6 -C 10  membered aryl, C 3 -C 11  cycloalkyl, 4-12 membered heterocyclyl, C 4 -C 11  cycloalkenyl, and 5-6 membered heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  alkoxy, F, Cl, Br and I; \n R 12 , at each occurrence, is independently selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 6 -C 10  membered aryl, C 3 -C 11  cycloalkyl, 4-12 membered heterocyclyl, C 4 -C 11  cycloalkenyl, and 5-6 membered heteroaryl; \n R 13 , at each occurrence, is independently selected from the group consisting of C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 6 -C 10  membered aryl, 5-11 membered heteroaryl, C 3 -C 11 cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl; wherein each R 3  C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of OH, oxo, CN, NO 2 , F, Cl, Br and I; wherein each R 13  C 6 -C 10  membered aryl, 5-11 membered heteroaryl, C 3 -C 11 cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  alkoxy, 5-6 membered heteroaryl, OH, oxo, CN, NO 2 , F, Cl, Br and I; and \n R 14 , at each occurrence, is independently selected from the group consisting of C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 6 -C 10  membered aryl, 5-11 membered heteroaryl, C 3 -C 11 cycloalkyl, C 4 -C 11  cycloalkenyl, and 4-12 membered heterocyclyl; wherein each R 4  C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl is optionally substituted with one or more substituents independently selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  alkoxy, 5-6 membered heteroaryl, 4-12 membered heterocyclyl, OH, oxo, CN, NO 2 , F, Cl, Br and I; \n with the proviso that the compound is not 1-(3,4-dimethylphenyl)-N-(naphthalene-1-sulfonyl)cyclopentane-1-carboxamide.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.6087
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15902802', '15726075', '15723896', '14858174', '15287911']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8103635561464417
- 35 USC 102 Novelty (BERT): 0.5781137675151738
- Combined Prediction Score: 0.7871385772833149
- Mean Citation Score: 392.899102
- Max Citation Score: 463.06012
- Similarity Product: 419.2565821730757

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test