PATENT CLAIM ANALYSIS

Application Number: 15874938
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["530", "387300"]

Abstract:
The present invention relates to biological materials against P2X7 and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the biological materials of the present invention inhibit the biological activity of the P2X7 receptor, such as activation by ATP.

Claim (Index 33):
The polypeptide according to  claim 32 ,\n wherein one of the at least two immunoglobulin single variable domains that bind P2X7 comprises an amino acid sequence: wherein CDR1 is SEQ ID NO: 34 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 34; and wherein CDR2 is SEQ ID NO: 62 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 62; and wherein CDR3 is SEQ ID NO: 90 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 90, and wherein the other of the at least two immunoglobulin single variable domains that bind P2X7 comprises an amino acid sequence: wherein CDR1 is SEQ ID NO: 34 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 34; CDR2 is SEQ ID NO: 62 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 62; and CDR3 is SEQ ID NO: 90 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 90; or wherein CDR1 is SEQ ID NO: 35 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 35; CDR2 is SEQ ID NO: 63 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 63; and CDR3 is SEQ ID NO: 91 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 91; or wherein CDR1 is SEQ ID NO: 40 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 40; CDR2 is SEQ ID NO: 68 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 68; and CDR3 is SEQ ID NO: 96 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 96; or wherein CDR1 is SEQ ID NO: 36 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 36; CDR2 is SEQ ID NO: 64 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 64; and CDR3 is SEQ ID NO: 92 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 92; or wherein CDR1 is SEQ ID NO: 37 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 37; CDR2 is SEQ ID NO: 65 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 65; and CDR3 is SEQ ID NO: 93 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 93; or wherein CDR1 is SEQ ID NO: 38 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 38; CDR2 is SEQ ID NO: 66 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 66; and CDR3 is SEQ ID NO: 94 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 94; or wherein CDR1 is SEQ ID NO: 39 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 39; CDR2 is SEQ ID NO: 67 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 67; and CDR3 is SEQ ID NO: 95 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 95; or wherein CDR1 is SEQ ID NO: 41 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 41; CDR2 is SEQ ID NO: 69 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 69; and CDR3 is SEQ ID NO: 97 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 97; or wherein CDR1 is SEQ ID NO: 42 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 42; CDR2 is SEQ ID NO: 70 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 70; and CDR3 is SEQ ID NO: 98 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 98; or wherein CDR1 is SEQ ID NO: 43 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 43; CDR2 is SEQ ID NO: 71 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 71; and CDR3 is SEQ ID NO: 99 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 99; or wherein CDR1 is SEQ ID NO: 44 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 44; CDR2 is SEQ ID NO: 72 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 72; and CDR3 is SEQ ID NO: 100 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 100; or wherein CDR1 is SEQ ID NO: 45 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 45; CDR2 is SEQ ID NO: 73 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 73; and CDR3 is SEQ ID NO: 101 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 101; or wherein CDR1 is SEQ ID NO: 46 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 46; CDR2 is SEQ ID NO: 74 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 74; and CDR3 is SEQ ID NO: 102 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 102; or wherein CDR1 is SEQ ID NO: 47 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 47; CDR2 is SEQ ID NO: 75 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 75; and CDR3 is SEQ ID NO: 103 or a polypeptide that has 1 amino acid difference with SEQ ID NO: 103.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 86.0
- Lexical Diversity: 1.82979
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14403754', '14382027', '13937718', '15562437', '14402301']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6693675523151812
- 35 USC 102 Novelty (BERT): 0.7067840725349603
- Combined Prediction Score: 0.6731092043371592
- Mean Citation Score: 459.27668400000016
- Max Citation Score: 830.6749
- Similarity Product: 710.2303231413008

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test