PATENT CLAIM ANALYSIS

Application Number: 15934541
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["435", "007400"]

Abstract:
Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate to severe traumatic brain injury (TBI), using an early biomarker, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1). Also disclosed here are methods that aid in determining whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels and changes in levels of UCH-L1 in one or more samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

Claim (Index 26):
A method of aiding in the determination of whether to perform a head computerized tomography (CT) scan on a human subject that has sustained or may have sustained a head injury, the method comprising:\n c) performing an assay to detect or measure ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) in at least two samples obtained from the subject, the first sample taken from the subject within 24 hours of the suspected head injury and the second sample taken from the subject from about 3 to about 6 hours after the first sample is taken; d) determining the level of UCH-L1 in each of the first sample and second sample and determining if the level of UCH-L1 decreases or increases from the first sample to the second sample; and e) determining whether to perform a CT scan on the subject based on whether the level of UCH-L1 decreases, increases, or remains the same from the first sample to the second sample, wherein:\n (i) the CT scan is performed when the level of UCH-L1 in the first sample is higher than a reference level of UCH-L1, and wherein the CT scan is not performed when the level of UCH-L1 in the first sample is lower than a reference level of UCH-L1; \n (ii) the CT scan is performed when there is a statistically significant increase or decrease in the level of UCH-L1 in the first sample to the level of UCH-L1 in the second sample, and wherein the CT scan is not performed when there is no statistically significant increase or decrease from the level of UCH-L1 in the first sample to the level of UCH-L1 in the second sample; or \n (iii) the CT scan is performed when the level of UCH-L1 decreases or increases by at least an absolute amount from the first sample to the second sample, and wherein the CT scan is not performed when there is no decrease or increase by at least an absolute amount in the level of UCH-L1 from the first sample to the second sample.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 90.0
- Lexical Diversity: 1.88158
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12822560', '11107248', '15802489', '12950142', '14449093']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5831969391458186
- 35 USC 102 Novelty (BERT): 0.5272967688166398
- Combined Prediction Score: 0.5776069221129008
- Mean Citation Score: 317.504772
- Max Citation Score: 339.23605
- Similarity Product: 250.3426492205709

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test