PATENT CLAIM ANALYSIS

Application Number: 15968950
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "006900"]

Abstract:
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position T of GLP-1(7-37), where T is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to GLP-1(7-37); wherein the first K residue is designated K 27 , and the second K residue is designated K T ; which derivative comprises two albumin binding moieties attached to K 27  and K T , respectively, via a linker, wherein the albumin binding moiety comprises a protracting moiety selected from HOOC—(CH 2 ) 2 —CO— and HOOC—C 6 H 4 —O—(CH 2 ) y —CO—; in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; wherein the linker comprises an element of the formula —NH—(CH 2 ) 2 —(O—(CH 2 ) 2 ) k —O—(CH 2 ) n —CO—, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel GLP-1 analogues. The derivatives are suitable for oral administration.

Claim (Index 10):
The derivative of  claim 1 , wherein the derivative is a derivative of a GLP-1 analogue of Formula I:\n Xaa 7 -Xaa 8 -Glu-Gly-Thr-Xaa 12 -Thr-Ser-Asp-Xaa 16 -Ser-Xaa 18 -Xaa 19 -Xaa 20 -Glu-Xaa 22 -Xaa 23 -Lys-Xaa 25 -Xaa 26 -Lys-Phe-Ile-Xaa 30 -Xaa 31 -Leu-Val-Xaa 34 -Xaa 35 -Xaa 36 -Xaa 37 -Xaa 38 -Xaa 39 ,\u2003\u2003Formula I: wherein\n Xaa 7  is selected from the group consisting of L-histidine, imidazopropionyl, \u03b1-hydroxy-histidine, D-histidine, desamino-histidine, 2-amino-histidine, \u03b2-hydroxy-histidine, homohistidine, N \u03b1 -acetyl-histidine, N \u03b1 -formyl-histidine, \u03b1-fluoromethyl-histidine, \u03b1-methyl-histidine, 3-pyridylalanine, 2-pyridylalanine, and 4-pyridylalanine; \n Xaa 8  is selected from the group consisting of Ala, Gly, Val, Leu, Ile, Thr, Ser, Lys, Aib, (1-aminocyclopropyl) carboxylic acid, (1-aminocyclobutyl) carboxylic acid, (1-aminocyclopentyl) carboxylic acid, (1-aminocyclohexyl) carboxylic acid, (1-aminocycloheptyl) carboxylic acid, and (1-aminocyclooctyl) carboxylic acid; \n Xaa 12  is selected from the group consisting of Lys and Phe; \n Xaa 16  is selected from the group consisting of Val and Leu; \n Xaa 18  is selected from the group consisting of Ser, Arg, Asn, Gln, and Glu; \n Xaa 19  is selected from the group consisting of Tyr and Gln; \n Xaa 20  is selected from the group consisting of Leu, Lys, and Met; \n Xaa 22  is selected from the group consisting of Gly, Glu, Lys, and Aib; \n Xaa 23  is selected from the group consisting of Gln, Glu, and Arg; \n Xaa 25  is selected from the group consisting of Ala and Val; \n Xaa 26  is selected from the group consisting of Val, His, and Arg; \n Xaa 30  is selected from the group consisting of Ala, Glu, and Arg; \n Xaa 31  is selected from the group consisting of Trp and His; \n Xaa 34  is selected from the group consisting of Glu, Asn, Gly, Gln, and Arg; \n Xaa 35  is selected from the group consisting of Gly, Aib, and absent; \n Xaa 36  is selected from the group consisting of Arg, Gly, Lys, and absent; \n Xaa 37  is selected from the group consisting of Gly, Ala, Glu, Pro, Lys, Arg, and absent; \n Xaa 38  is selected from the group consisting of Ser, Gly, Ala, Glu, Gln, Pro, Arg, and absent; and \n Xaa 39  is selected from the group consisting of Gly and absent.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 93.0
- Lexical Diversity: 2.62162
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15346323', '14009902', '14961064', '13883946', '13882947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8793467072211566
- 35 USC 102 Novelty (BERT): 0.6290757881960397
- Combined Prediction Score: 0.8543196153186449
- Mean Citation Score: 570.27306
- Max Citation Score: 599.13586
- Similarity Product: 558.3082247915005

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test