PATENT CLAIM ANALYSIS

Application Number: 15752527
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "061000"]

Abstract:
The disclosure relates to the identification of a novel molecular signature based on the differential expression of circulating microRNAs (miRNA) in serum samples specific to patients with clinically significant diseases or disorders, such as cancer.

Claim (Index 1):
A method of detecting aggressive prostate cancer in an individual, the method comprising: isolating miRNA from a sample from the individual; ligating the miRNA to a universal linker; hybridizing the miRNA to a nucleic acid that is on a surface, wherein the nucleic acid is complementary to miR-433 and/or miR-200c; contacting the miRNA with a spherical nucleic acid (SNA), wherein the SNA comprises a polynucleotide that is sufficiently complementary to the universal linker to hybridize under appropriate conditions; wherein detection of the SNA is indicative of aggressive prostate cancer in the individual.

Metadata:
- Claim Count in Document: 25.0
- Percentile: 88.0
- Lexical Diversity: 1.08333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14686593', '12609847', '12963468', '14863828', '13390028']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6162264412602059
- 35 USC 102 Novelty (BERT): 0.5167188689318211
- Combined Prediction Score: 0.6062756840273674
- Mean Citation Score: 290.6146960000001
- Max Citation Score: 317.4949299999999
- Similarity Product: 219.5355027290665

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test