PATENT CLAIM ANALYSIS

Application Number: 15998503
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["514", "291000"]

Abstract:
Disclosed are a pharmaceutical composition comprising tacrolimus and a preparation method thereof.

Claim (Index 11):
A method of preparing a pharmaceutical composition comprising tacrolimus, the method comprising:\n (1) preparing a solution: dissolving the tacrolimus in ethanol and obtaining a clear solution, (2) preparing premixed excipients: mixing a crystallization inhibitor, a disintegrant and a pharmaceutically acceptable filler homogeneously using a wet granulating machine and obtaining premixed excipients, (3) preparing soft materials: mixing the solution obtained in procedure (1) and the premixed excipients obtained in procedure (2) using a wet granulating machine and obtaining soft materials by wet granulation, (4) drying the soft materials in a vacuum oven at 50\u00b0 C. and granulating by forcing the soft materials through a 40-mesh sieve using a granulating machine, and (5) adding a pharmaceutically acceptable filler and a lubricant into the granulated mass, mixing homogeneously, and filling in hard capsule shells, wherein the mass ratio of tacrolimus to the crystallization inhibitor is 1:0.5 to 1:2.5.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 96.0
- Lexical Diversity: 1.08333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13036010', '15105048', '14129713', '14860829', '13142116']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7414814477668094
- 35 USC 102 Novelty (BERT): 0.50242060249553
- Combined Prediction Score: 0.7175753632396814
- Mean Citation Score: 253.591482
- Max Citation Score: 261.28024
- Similarity Product: 209.86275107790945

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test