PATENT CLAIM ANALYSIS

Application Number: 16313716
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-07
Patent Classification: ["544", "333000"]

Abstract:
The present invention discloses a compound for regulating protein kinase activity and used for treating or preventing diseases associated with protein kinases. Specifically, the present invention relates to a benzofuran pyrazole amine protein kinase inhibitor which belongs to compounds that regulate anaplastic lymphoma kinase (ALK), and provides a method of preparing such a compound and a pharmaceutical use of such a compound in the treatment or prevention of diseases associated with ALK. The inhibitor can solve the problem of the drug resistance of the first generation and the second generation of ALK inhibitors.

Claim (Index 6):
The benzofuran pyrazolamines protein kinase inhibitor according to  claim 3  the inhibitor is a compound having the following general structural formula (Ic) or a pharmaceutically acceptable salt thereof: wherein R 1  is selected from R 0 , R 8  and R 9  are each independently selected from one or more of the group consisting of hydrogen, C 1-6  alkyl, acyl, amido, sulfo group, sulfanilamido, hydroxyl, aryl and heterocyclyl; R 2  is hydrogen, halogen, C 1-6  alkyl, halogenated C 1-6  alkyl, C 1-6  alkoxy, halogenated C 1-6  alkoxy, cyano or amino; R 6  is hydrogen, halogen, C 1-6  alkyl, halogenated C 1-6  alkyl, C 1-6  alkoxy, or halogenated C 1-6  alkoxy, and R 6  constitutes R form, S form or enantiomer; R 10  and R 11  are simultaneously hydrogen, or one of R 10  and R 11  is hydrogen and the other is halogen, C 1-6  alkyl, halogenated C 1-6  alkyl, C 1-6  alkoxy, halogenated C 1-6  alkoxy, cyano or amino; R 13  is selected from the group consisting of hydrogen, C 1-6  alkoxy, C 1-6  alkyl, C 3-6  cycloalkyl, amido, amino-containing C 1-6  alkyl, C 1-6  alkylcarbonyl, aryl and heterocyclyl; R 14  is selected from one or more of the group consisting of hydrogen, halogen, C 1-6  alkyl, C 1-6  alkoxy, C 3-6  cycloalkyl, amino, amido, hydroxyl, carbonyl, ureido, sulfone group, sulfamido, phosphoroso, boryl, aryl and heterocyclyl; the heterocyclyl is a 3-6 membered heterocyclic ring containing one or more of N and O atoms; m is selected from any integer from 0 to 3; and p is selected from any integer from 0 to 6.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 98.0
- Lexical Diversity: 1.69492
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14926729', '14071953', '13968470', '15320887', '15059542']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8063649423078164
- 35 USC 102 Novelty (BERT): 0.5366349030440013
- Combined Prediction Score: 0.7793919383814348
- Mean Citation Score: 345.831548
- Max Citation Score: 374.42175
- Similarity Product: 281.0306252957136

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test