PATENT CLAIM ANALYSIS

Application Number: 15992497
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["424", "203100"]

Abstract:
Described are immunogenic proteins against  Clostridium difficile . Also described are compositions comprising the immunogenic proteins. Further described are methods of preventing or treating a  Clostridium difficile  infection in a subject in need thereof.

Claim (Index 17):
An immunogenic protein comprising:\n i) a glucosyltransferase domain (GT) of  Clostridium difficile  toxin TcdB; ii) a cysteine proteinase domain (CPD) of  Clostridium difficile  toxin TcdB; iii) a receptor binding domain (RBD) of  Clostridium difficile  toxin TcdA; and iv) flagellin of  Salmonella typhimurium  (sFliC); wherein the GT of  Clostridium difficile  toxin TcdB comprises a W102A amino acid substitution and a D288N amino acid substitution and the CPD of  Clostridium difficile  toxin TcdB comprises a C698A amino acid substitution, and wherein the immunogenic protein lacks a transmembrane domain.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.44
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15905598', '14374792', '15119323', '15191739', '14529147']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.70150076781816
- 35 USC 102 Novelty (BERT): 0.6101274386258639
- Combined Prediction Score: 0.6923634348989304
- Mean Citation Score: 428.11094800000006
- Max Citation Score: 572.0629
- Similarity Product: 466.87710489027495

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test