PATENT CLAIM ANALYSIS

Application Number: 15917549
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["435", "006110"]

Abstract:
The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.

Claim (Index 6):
The system of  claim 5 , wherein the Cas13a, Cas13b, or Cas13c effector protein is from an organism selected from the group consisting of:  Leptotrichia shahii; Leptotrichia wadei  (Lw2);  Listeria seeligeri; Lachnospiraceae bacterium  MA2020 ; Lachnospiraceae bacterium  NK4A179 ; [Clostridium] aminophilum  DSM 10710 ; Carnobacterium gallinarum  DSM 4847;  Carnobacterium gallinarum  DSM 4847 (second CRISPR Loci);  Paludibacter propionicigenes  WB4;  Listeria weihenstephanensis  FSL R9-0317;  Listeriaceae bacterium  FSL M6-0635;  Leptotrichia wadei  F0279;  Rhodobacter capsulatus  SB 1003;  Rhodobacter capsulatus  R121;  Rhodobacter capsulatus  DE442 ; Leptotrichia buccalis  C-1013-b;  Herbinix hemicellulosilytica; [Eubacterium] rectale; Eubacteriaceae bacterium  CHKC1004;  Blautia  sp. Marseille-P2398;  Leptotrichia  sp. oral taxon 879 str. F0557;  Lachnospiraceae bacterium  NK4A144;  Chloroflexus aggregans; Demequina aurantiaca; Thalassospira  sp. TSL5-1;  Pseudobutyrivibrio  sp. OR37 ; Butyrivibrio  sp. YAB3001;  Blautia  sp. Marseille-P2398;  Leptotrichia  sp. Marseille-P3007,  Bacteroides ihuae; Porphyromonadaceae bacterium  KH3CP3RA;  Listeria riparia; Insolitispirillum peregrinum; Fusobacterium necrophorum  subsp.  funduliformm; F. necrophorum; F. necrophorum; F. perfoetens; F. ulcerans ; or  Anaerosalibacter  sp.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 90.0
- Lexical Diversity: 1.38889
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15917546', '15467922', '15916271', '14975085', '15897089']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7212252095587336
- 35 USC 102 Novelty (BERT): 0.6024789199226631
- Combined Prediction Score: 0.7093505805951266
- Mean Citation Score: 415.336298
- Max Citation Score: 717.7631
- Similarity Product: 447.3121453235865

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test