PATENT CLAIM ANALYSIS

Application Number: 15892295
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "044000"]

Abstract:
Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Claim (Index 68):
A polynucleotide sequence encoding a mutated form of thymidine kinase from a human herpes simplex virus type 1 (HSV1-TK) for increasing cell kill activity, wherein the encoded HSV1-TK is mutated at either amino acid residue 32 or 33, wherein the amino acid residues correspond to positions 32 and 33 of SEQ ID NO: 2, wherein amino acid residues 32 and 33 are each independently mutated to an acidic amino acid or to cysteine, and wherein the mutated form of thymidine kinase increases cell kill activity relative to a wild-type thymidine kinase.

Metadata:
- Claim Count in Document: 83.0
- Percentile: 88.0
- Lexical Diversity: 1.275
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14214522', '14214448', '15516012', '10457604', '15211586']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7345597138408801
- 35 USC 102 Novelty (BERT): 0.7221742644050563
- Combined Prediction Score: 0.7333211688972978
- Mean Citation Score: 426.671468
- Max Citation Score: 831.2875
- Similarity Product: 746.3250357344748

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test