PATENT CLAIM ANALYSIS

Application Number: 16008461
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "04400A"]

Abstract:
The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.

Claim (Index 4):
A double stranded ribonucleic acid (dsRNA) agent capable of inhibiting the expression of Serpina1 in a cell, wherein said dsRNA agent comprises a sense strand substantially complementary to an antisense strand, wherein said antisense strand comprises a region substantially complementary to part of an mRNA encoding Serpina1, wherein each strand is about 14 to about 30 nucleotides in length, wherein said dsRNA agent is represented by formula (III):\n sense: 5\u2032 n p -N a -(XXX) i -N b -YYY-N b -(ZZZ) j -N a - n q 3\u2032 antisense: 3\u2032 n p \u2032-N a \u2032-(X\u2032X\u2032X\u2032) k -N b \u2032-Y\u2032Y\u2032Y\u2032-N b \u2032-(Z\u2032Z\u2032Z\u2032) l -N a \u2032- n q \u20325\u2032\u2003\u2003(III) wherein: i, j, k, and l are each independently 0 or 1; p, p\u2032, q, and q\u2032 are each independently 0-6; each N a  and N a \u2032 independently represents an oligonucleotide sequence comprising 0-25 nucleotides which are either modified or unmodified or combinations thereof, each sequence comprising at least two differently modified nucleotides;\n each N b  and N b \u2032 independently represents an oligonucleotide sequence comprising 0-10 nucleotides which are either modified or unmodified or combinations thereof;\n each n p , n p \u2032, n q , and n q \u2032, each of which may or may not be present, independently represents an overhang nucleotide; \n XXX, YYY, ZZZ, X\u2032X\u2032X\u2032, Y\u2032Y\u2032Y\u2032, and Z\u2032Z\u2032Z\u2032 each independently represent one motif of three identical modifications on three consecutive nucleotides; \n modifications on N b  differ from the modification on Y and modifications on N b \u2032 differ from the modification on Y\u2032; and \n wherein the sense strand is conjugated to at least one ligand.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 94.0
- Lexical Diversity: 1.56667
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15399820', '14284745', '14947025', '14976261', '14699140']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8706552161069184
- 35 USC 102 Novelty (BERT): 0.6867444266382265
- Combined Prediction Score: 0.8522641371600492
- Mean Citation Score: 683.64558
- Max Citation Score: 773.87994
- Similarity Product: 681.2709932416177

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test