PATENT CLAIM ANALYSIS

Application Number: 15944331
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["435", "146000"]

Abstract:
The subject invention relates to a process of preparing (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying with certain carbon and nitrogen sources. These microorganisms include a Glutamic acid Bacterium HR057 strain or one type of genetically engineered  Corynebacterium Glutamicum.

Claim (Index 1):
A process for producing (R)-3-hydroxybutyric acid comprising fermenting a fermentation broth with a nonpathogenic microorganism, wherein the fermentation broth comprises carbon and nitrogen sources and an enzyme that is overexpressed by the nonpathogenic microorganism, the carbon and nitrogen sources are directly converted into (R)-3-hydroxybutyric acid by one-step fermentation with the nonpathogenic microorganism, the (R)-3-hydroxybutyric acid was recovered from fermentation broth after it was excreted during fermentation, wherein the nonpathogenic microorganism is selected from a group consisting of  Corynebacterium glutamicum, Bacillus subtilis, Brevibacterium lactofermentum, Brevibacterium difficile, Brevibacterium flavum  and  Brevibacterium breve ; and the nonpathogenic microorganism has the following biotransformation capability: converting pyruvic acid and coenzyme A to acetyl-CoA, converting acetyl-CoA into acetoacetyl-CoA, converting acetoacetyl-CoA to acetoacetic acid, and converting acetoacetic acid to (R)-3-hydroxybutyric acid.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 91.0
- Lexical Diversity: 1.4
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13353426', '14712596', '13379654', '13256849', '13321295']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5887546370554778
- 35 USC 102 Novelty (BERT): 0.4891668743432328
- Combined Prediction Score: 0.5787958607842534
- Mean Citation Score: 216.87653
- Max Citation Score: 224.51154
- Similarity Product: 162.25470402606726

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test