PATENT CLAIM ANALYSIS

Application Number: 15745461
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["548", "255000"]

Abstract:
The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those routes.

Claim (Index 28):
The method of  claim 10 , further comprising:\n treating the mixture of zinc dust and dimethylformamide with 1,2-dibromoethane and heating the mixture to about 50\u00b0 C. to about 100\u00b0 C. for about 1 to 10 minutes at ambient pressure; cooling the mixture to ambient temperature, adding trimethylsilyl chloride and agitating the mixture for about 1 to 10 minutes; adding zinc chloride in diethyl ether to the mixture; adding the Compound (IIa) to the mixture; heating the mixture to a temperature of about 50\u00b0 C. to about 100\u00b0 C., adding 1,2-dibromoethane and trimethylsilyl chloride, and agitating the mixture about 50\u00b0 C. to about 100\u00b0 C. for a time of about 8 hours to about 24 hours; adding tetrakis(triphenylphosphine)palladium(0) and Compound (IIIa) to the mixture; and\n heating the mixture to a temperature of about 50\u00b0 C. to about 100\u00b0 C. to form Compound (I).

Metadata:
- Claim Count in Document: 108.0
- Percentile: 86.0
- Lexical Diversity: 1.125
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14853883', '14946137', '15355630', '15841828', '13889980']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6713554545928184
- 35 USC 102 Novelty (BERT): 0.5002996021132546
- Combined Prediction Score: 0.6542498693448621
- Mean Citation Score: 216.948504
- Max Citation Score: 220.2003
- Similarity Product: 151.87655853477716

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test