PATENT CLAIM ANALYSIS

Application Number: 16162459
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["514", "256000"]

Abstract:
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I or Formula II, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , Y 1 , Y 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12  and R 13  are as defined in the specification. The inventive Formula I and Formula II compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

Claim (Index 15):
The compound according to  claim 1  selected from\n 1-(6-aminopyrimidin-4-yl)-6-chloro-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-4-isobutyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-2-methyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-6-chloro-4-isobutyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-6-chloro-4-isobutyl-N-methyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-6-chloro-4-isobutyl-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide, \n (1-(6-aminopyrimidin-4-yl)-6-chloro-4-isobutyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-chloro-4-isobutyl-1H-benzo[d]imidazol-5-yl)(pyrrolidin-1-yl)methanone, \n 1-(6-aminopyrimidin-4-yl)-4-isobutyl-N,N,6-trimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-4-isobutyl-N,N,6-trimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-4-isobutyl-N,N,6-trimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-4-cyclohexyl-N,N,6-trimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-4-cyclohexyl-N,N,6-trimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-4-cyclohexyl-N,N,6-trimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-N,N,6-trimethyl-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-N,N,6-trimethyl-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-N,N,6-trimethyl-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-isobutyl-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-isobutyl-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-6-chloro-4-cyclohexyl-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-cyclohexyl-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-cyclohexyl-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-6-chloro-N,N-dimethyl-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-N,N-dimethyl-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-N,N-dimethyl-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazole-5-carboxamide, \n (1-(6-aminopyrimidin-4-yl)-4-isobutyl-6-methyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-4-isobutyl-6-methyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-4-isobutyl-6-methyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-4-cyclohexyl-6-methyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-4-cyclohexyl-6-methyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-4-cyclohexyl-6-methyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-methyl-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-6-methyl-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-6-methyl-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-isobutyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-isobutyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-chloro-4-cyclohexyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-cyclohexyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-cyclohexyl-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-chloro-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-(1-methylpiperidin-3-yl)-1H-benzo[d]imidazol-5-yl)(azetidin-1-yl)methanone, \n 1-(6-aminopyrimidin-4-yl)-4-isobutyl-N,N,6-trimethyl-1H-indole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-4-isobutyl-N,N,6-trimethyl-1H-indole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-4-isobutyl-N,N,6-trimethyl-1H-indole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-4-cyclohexyl-N,N,6-trimethyl-1H-indole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-4-cyclohexyl-N,N,6-trimethyl-1H-indole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-4-cyclohexyl-N,N,6-trimethyl-1H-indole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-N,N,6-trimethyl-4-(1-methylpiperidin-3-yl)-1H-indole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-N,N,6-trimethyl-4-(1-methylpiperidin-3-yl)-1H-indole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-N,N,6-trimethyl-4-(1-methylpiperidin-3-yl)-1H-indole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-6-chloro-4-isobutyl-N,N-dimethyl-1H-indole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-isobutyl-N,N-dimethyl-1H-indole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-isobutyl-N,N-dimethyl-1H-indole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-6-chloro-4-cyclohexyl-N,N-dimethyl-1H-indole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-cyclohexyl-N,N-dimethyl-1H-indole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-cyclohexyl-N,N-dimethyl-1H-indole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-6-chloro-N,N-dimethyl-4-(1-methylpiperidin-3-yl)-1H-indole-5-carboxamide, \n 1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-N,N-dimethyl-4-(1-methylpiperidin-3-yl)-1H-indole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-N,N-dimethyl-4-(1-methylpiperidin-3-yl)-1H-indole-5-carboxamide, \n (1-(6-aminopyrimidin-4-yl)-4-isobutyl-6-methyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-4-isobutyl-6-methyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-4-isobutyl-6-methyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-4-cyclohexyl-6-methyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-4-cyclohexyl-6-methyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-4-cyclohexyl-6-methyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-methyl-4-(1-methylpiperidin-3-yl)-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-6-methyl-4-(1-methylpiperidin-3-yl)-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-6-methyl-4-(1-methylpiperidin-3-yl)-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-chloro-4-isobutyl-1H-indol-5-yl)(azetidin-1-yl)methanone \n (1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-isobutyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-isobutyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-chloro-4-cyclohexyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-cyclohexyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-cyclohexyl-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-chloro-4-(1-methylpiperidin-3-yl)-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-methylpyrimidin-4-yl)-6-chloro-4-(1-methylpiperidin-3-yl)-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-amino-5-chloropyrimidin-4-yl)-6-chloro-4-(1-methylpiperidin-3-yl)-1H-indol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-chloro-4-(1-methylpiperidin-3-yl)-1H-indazol-5-yl)(azetidin-1-yl)methanone, \n (1-(6-aminopyrimidin-4-yl)-6-chloro-4-(1-methylpiperidin-3-yl)-1H-benzo[d][1,2,3]triazol-5-yl)(azetidin-1-yl)methanone, \n (3-(6-aminopyrimidin-4-yl)-5-chloro-1-methyl-7-(1-methylpiperidin-3-yl)-1H-indol-6-yl)(azetidin-1-yl)methanone, \n (3-(6-aminopyrimidin-4-yl)-5-chloro-1-methyl-7-(1-methylpiperidin-3-yl)-1H-indazol-6-yl)(azetidin-1-yl)methanone, \n (3-(6-aminopyrimidin-4-yl)-5-chloro-1-methyl-7-(1-methylpiperidin-3-yl)-1H-pyrrolo[3,2-b]pyridin-6-yl)(azetidin-1-yl)methanone, \n (3-(6-aminopyrimidin-4-yl)-5-chloro-1-methyl-7-(1-methylpiperidin-3-yl)-1H-pyrazolo[4,3-b]pyridin-6-yl)(azetidin-1-yl)methanone, \n 1-(6-amino-5-chloropyrimidin-4-yl)-4-isobutyl-1H-indole-5-carboxamide, \n 3-(6-amino-5-chloropyrimidin-4-yl)-7-isobutyl-1-methyl-1H-indole-6-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-4-isobutyl-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-aminopyrimidin-4-yl)-4-isobutyl-N,N-dimethyl-1H-benzo[d]imidazole-5-carboxamide, \n 1-(6-amino-5-chloropyrimidin-4-yl)-4-isobutyl-1H-indazole-5-carboxamide, and \n 1-(6-amino-5-chloropyrimidin-4-yl)-4-isobutyl-1H-benzo[d]imidazole-5-carboxamide.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 97.0
- Lexical Diversity: 2.07576
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15337184', '14426369', '13420988', '13745734', '15355271']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7916139519940544
- 35 USC 102 Novelty (BERT): 0.5376217436963702
- Combined Prediction Score: 0.766214731164286
- Mean Citation Score: 324.329874
- Max Citation Score: 346.22852
- Similarity Product: 250.4690982297612

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test