PATENT CLAIM ANALYSIS

Application Number: 16038968
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["514", "252120"]

Abstract:
(−)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.

Claim (Index 40):
A compound of Formula (V): wherein: R 1  and R 7  are each independently hydrogen, carbonyl, thiocarbonyl, imine, oxime, hydroxyl, halogen, nitro, alkyl, alkenyl, alkynyl, cyano, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, alkylsilyloxy, or acylamino; each instance of R 2 , R 3 , R 4 , and R 5  is independently hydrogen, carbonyl, thiocarbonyl, imine, oxime, hydroxyl, halogen, nitro, alkyl, alkenyl, alkynyl, cyano, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, alkylsilyloxy, acylamino, aryl, heteroaryl, carbocyclyl, or heterocyclyl; each instance of R 8 , R 9 , R 10 , and R 11  is independently hydrogen, carbonyl, thiocarbonyl, hydroxyl, halogen, nitro, alkyl, alkenyl, alkynyl, cyano, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, alkylsilyloxy, acylamino, aryl, heteroaryl, carbocyclyl, or heterocyclyl; R 6  is hydrogen, hydroxyl, halogen, nitro, alkyl, alkenyl, alkynyl, cyano, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, alkylsilyloxy, or acylamino; or any two of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , together with the carbon atoms to which they are attached, form an aryl, heteroaryl, carbocyclyl, or heterocyclyl; or any two of R 7 , R 8 , R 9 , R 10 , and R 11 , together with the carbon atoms to which they are attached, form an aryl, heteroaryl, carbocyclyl, or heterocyclyl; R 15  is hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, sulfonate, sulfone, sulfoxide, acyl, acylamino, aryl, heteroaryl, carbocyclyl, heterocyclyl, aralkyl, aralkyloxy, hetaralkyl, carbocyclylalkyl, or heterocyclylalkyl; and X is hydrogen, oxo (\u2550O), \u2550S, \u2550NH, \u2550N-alkyl, \u2550NOH, hydroxyl, halogen, nitro, alkyl, alkenyl, alkynyl, cyano, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, alkylsilyloxy, acylamino, aryl, heteroaryl, carbocyclyl, heterocyclyl, aralkyl, aralkyloxy, hetaralkyl, carbocyclylalkyl, or heterocyclylalkyl; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 95.0
- Lexical Diversity: 1.42308
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15366590', '14972475', '14514001', '15081157', '14960799']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8423254466561366
- 35 USC 102 Novelty (BERT): 0.5763614690811815
- Combined Prediction Score: 0.8157290488986411
- Mean Citation Score: 493.983978
- Max Citation Score: 515.08453
- Similarity Product: 380.2592903272551

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test