PATENT CLAIM ANALYSIS

Application Number: 16329070
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-07
Patent Classification: ["514", "04400A"]

Abstract:
Use of an ErbB2 inhibitor for promoting ErbB2-regulated autophagic degradation or clearance of APP-C99 and APP intracellular domain (AICD) and/or alleviating production of Abeta 40 and Abeta 42 in a subject in need thereof is disclosed. Use of an ErbB2 inhibitor for rescuing ErbB2-mediated inhibition of autophagic flux in a subject in need thereof is also disclosed. Use of an ErbB 2  inhibitor for enhancing spatial learning and memory, and/or for cognitive improvement, in a subject with ErbB2-associated Alzheimer's disease is further disclosed. Also disclosed is use of an ErbB2 inhibitor for reducing intracellular levels of C99 and AICD without affecting extracellular domain-truncated Notch and Notch intracellular domain in a subject in need thereof.

Claim (Index 13):
The method of  claim 1 , wherein the subject exhibits one of the following characteristics:\n (i) loss of memory; (ii) loss of spatial memory and learning ability; and (iii) over-expression and/or a high level of ErbB2 in the hippocampus of the brain.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 99.0
- Lexical Diversity: 1.92188
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15553786', '14188318', '13307485', '14913515', '14653442']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7627901122996252
- 35 USC 102 Novelty (BERT): 0.5095298025071381
- Combined Prediction Score: 0.7374640813203766
- Mean Citation Score: 234.318694
- Max Citation Score: 245.26064
- Similarity Product: 156.45487477036474

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test