PATENT CLAIM ANALYSIS

Application Number: 16328262
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["378", "073000"]

Abstract:
A  3 D printed hybrid nozzle device combining a microfluidic mixer with a liquid jet injector that addresses the bottleneck of investigating substrate-initiated biological reaction paths employing serial crystallography with XFELs. The hybrid nozzle provides for injecting aqueous protein crystal jets after fast mixing (<5 ms), reaching reaction time points (e.g., about 10 ms to about 150 ms) suitable to resolve enzyme kinetics.

Claim (Index 1):
A system for conducting time-resolved serial femtosecond X-ray crystallography, the system comprising:\n a hybrid nozzle including a microfluidic mixer integrally formed with a liquid jet injector, the hybrid nozzle further including\n a housing; \n a first fluid inlet channel formed in the housing and configured to receive a substrate solution, \n a second fluid inlet channel formed in the housing and configured to receive a crystal suspension, and \n an outlet channel formed in the housing and coaxially formed with the second fluid inlet channel and in fluid communication with the first fluid inlet channel to provide mixing of the substrate solution and the crystal suspension within 1 ms to 5 ms, and \n wherein the mixture is transported to a chamber via the liquid jet injector for crystallographic analysis.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 99.0
- Lexical Diversity: 1.22034
- Patent Class: 378.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15509376', '13896303', '12893915', '10046071', '10138959']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6442479728232512
- 35 USC 102 Novelty (BERT): 0.4469298456635317
- Combined Prediction Score: 0.6245161601072793
- Mean Citation Score: 185.406552
- Max Citation Score: 207.17639
- Similarity Product: 159.5000076173985

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test