PATENT CLAIM ANALYSIS

Application Number: 15741846
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["544", "385000"]

Abstract:
The invention relates to a process for preparing 2,6-bis(methionyl)-1,4-dketopiperazine, comprising the following steps: a) heating a reaction mixture comprising methionine and polar protic solvent at a temperature of less than 170.0° C., while passing an inert gas stream over or through the reaction mixture; b) obtaining 2,6-bis(methionyl)-1,4-diketopiperazine.   The invention further relates to a process for isolating 2,6-bis(methionyl)-1,4-diketopiperazine from a reaction mixture, comprising the following steps:  A1) diluting the reaction mixture comprising 2,6-bis(methionyl)-1,4-diketopiperazine with a polar solvent and water, with crystallization of 2,6-bis(methionyl)-1,4-diketopiperazine; or A2) diluting the reaction mixture comprising 2,6-bis(methionyl-1,4-diketopiperazine only with water without prior dilution with an organic solvent with or without pressure retention, with crystallization of 2,6-bis(mehionyl)-1,4-diketopiperazine; or A3) cooling the reaction mixture down or allowing it to cool down without addition of substances until a temperature, especially of 135.0° C. to less than 145.0° C., preferably of 138.0° C. to 142.0° C., is reached, at which the diketopiperazine starts to crystallize, and finally diluting it and hence cooling it by addition of water, with crystallization of 2,6-bis(methionyl)-1,4-dketopiperazine; B) removing the crystalized 2,6-bis(methionyl)-1,4-dketopiperazine obtained in A1) or A2) or A3) in solid form and washing it with a solvent, especially ethylene glycol, acetone or methanol, and finally washing with water.   More particularly, the present invention relates to a combination of a process for preparing 2,6-bis(methionyl)-1,4-diketopiperazine and a process for isolating 2,6-bis(methionyl)-1,4-diketopiperazine from a reaction mixture.

Claim (Index 13):
The process according to  claim 1 , wherein\n c1) the reaction mixture is cooled down to below 100.0\u00b0 C. by diluting with a polar solvent and water, with crystallization of 2,6-bis(methionyl)-1,4-diketopiperazine; or c2) the reaction mixture is cooled down with or without pressure retention solely by diluting with water without prior dilution with an organic solvent, with crystallization of 2,6-bis(methionyl)-1,4-diketopiperazine; or c3) the reaction mixture is cooled down or allowed to cool down without addition of substances until it reaches a temperature at which the diketopiperazine starts to crystallize, and finally diluted and cooled further by addition of water, with crystallization of 2,6-bis(methionyl)-1,4-diketopiperazine.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 86.0
- Lexical Diversity: 2.84906
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13616341', '14415687', '14543464', '13368172', '14415690']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7297844391442114
- 35 USC 102 Novelty (BERT): 0.4979696175524234
- Combined Prediction Score: 0.7066029569850327
- Mean Citation Score: 182.26898
- Max Citation Score: 203.98398
- Similarity Product: 138.8978182716036

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test