PATENT CLAIM ANALYSIS

Application Number: 16177149
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "300000"]

Abstract:
Diazanaphthalene compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a diazanaphthalene compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Claim (Index 13):
The compound of  claim 1 , wherein the compound of Formula I is selected from the group consisting of:\n N-(7-(1H-pyrazol-4-yl)quinazolin-2-yl)-1-isobutylpiperidine-4-carboxamide [908]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclopropanecarboxamide [909]; 4,4-difluoro-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [910]; trans-4-methoxy-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [911]; trans-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-4-morpholinocyclohexane-1-carboxamide [912]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) cyclohexane-1-carboxamide [913]; trans-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [914]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [915]; (S)-2-(3-fluoropyrrolidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [916]; (S)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)tetrahydrofuran-2-carboxamide [917]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [918]; 1-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [919]; 1-isopropyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [920]; 1-(tert-butyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [921]; 1-cyclopropyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [922]; 1-isobutyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [923]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-neopentylpiperidine-4-carboxamide [924]; 1-(2-fluoroethyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [925]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [926]; 1-butyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [927]; 1-benzoyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [928]; 1-(2,2-difluoropropyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [929]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)azetidine-3-carboxamide [930]; 1-(2,2-difluoroethyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [931]; 1-(2-fluoro-2-methylpropyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [932]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [933]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine-4-carboxamide [934]; 1-(2-methoxyethyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [935]; 1-(2-isopropoxyethyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [936]; 1,1-diisobutyl-4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)piperidin-1-ium [937]; 4-fluoro-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [938]; 4-fluoro-1-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [939]; 4-fluoro-1-isobutyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [940]; (S)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [941]; (R)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [942]; (S)-1-isobutyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [943]; (R)-1-isobutyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [944]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)tetrahydro-2H-pyran-4-carboxamide [945]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-1-yl)acetamide [946]; 2-(4-fluoropiperidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [947]; trans-4-amino-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [948]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide [949]; (S)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-2-carboxamide [950]; 2-(4-isobutylpiperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [951]; 2-(3,3-dimethylazetidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [952]; (R)-2-(3-fluoropyrrolidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [953]; (S)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [954]; 2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [955]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [956]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperidin-1-yl)acetamide [957]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)acetamide [958]; 2-(4-(difluoromethyl)piperidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [959]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [960]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)propanamide [961]; (R)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [962]; 2-(cyclobutyl(methyl)amino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [963]; 2-(diethylamino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [964]; 7-(2-fluoroethyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-7-azaspiro[3.5]nonane-2-carboxamide [965]; 4-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperazine-1-carboxamide [966]; (S)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)propanamide [967]; (R)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)propanamide [968]; (R)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)pyrrolidine-2-carboxamide [969]; 2-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-azaspiro[3.3]heptane-6-carboxamide [970]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [971]; 2-(2-fluoroethyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-azaspiro[3.3]heptane-6-carboxamide [972]; trans-4-(dimethylamino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [973]; 1-acetyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [974]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [975]; (S)-1-(2-fluoropropyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [976]; (R)-1-(2-fluoropropyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [977]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-1-yl)propanamide [978]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [979]; 1\u2032-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [980]; trans-4-(hydroxymethyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [981]; methyl 2-(4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)piperidin-1-yl)acetate [982]; 1-benzyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [983]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [984]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-morpholinoacetamide [985]; (S)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(3-methylmorpholino)acetamide [986]; (R)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(3-methylmorpholino)acetamide [987]; (S)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(2-methylmorpholino)acetamide [988]; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [989]; 2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [990]; 2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [991]; 2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) acetamide [992]; (S)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-morpholinopropanamide [993]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(morpholin-2-yl)acetamide [994]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylmorpholin-2-yl)acetamide [995]; 2-(4-ethylpiperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [996]; 2-(4-isopropylpiperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [997]; 2-(4-cyclopropylpiperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [998]; 2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [999]; (S)-2-(2,4-dimethylpiperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [1000]; 1-(2-hydroxyethyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1001]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxamide [1002]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(oxazol-2-ylmethyl)piperidine-4-carboxamide [1003]; (R)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-oxotetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxamide [1004]; (R)-1-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)pyrrolidine-2-carboxamide [1005]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(tetrahydro-2H-pyran-4-yl)piperidine-4-carboxamide [1006]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(pyrimidin-2-ylmethyl)piperidine-4-carboxamide [1007]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(pyrazin-2-ylmethyl)piperidine-4-carboxamide [1008]; 1-((5-methyl-1,2,4-oxadiazol-3-yl)methyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1009]; 1-(2-hydroxy-2-methylpropyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1010]; tert-butyl 2-(4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)piperidin-1-yl)acetate [1011]; 2-(4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)piperidin-1-yl)acetic acid [1012]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [1013]; tert-butyl (7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)carbamate [1014]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)but-2-ynamide [1015]; trans-4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)cyclohexane-1-carboxylic acid [1016]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-morpholinopropanamide [1017]; trans-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-morpholinocyclobutane-1-carboxamide [1018]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)quinuclidine-4-carboxamide [1019]; 1-isobutyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)azepane-4-carboxamide [1020]; 2-(4-methoxypiperidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [1021]; 2-(4-hydroxypiperidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [1022]; 3-(hydroxymethyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)bicyclo[1.1.1]pentane-1-carboxamide [1023]; 1-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)azepane-4-carboxamide [1024]; trans-4-(dimethylamino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1025]; trans-4-(bis(methyl-d 3 )amino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1026]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-((4-methylpiperazin-1-yl)methyl)bicyclo [1.1.1]pentane-1-carboxamide [1027]; methyl trans-4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)cyclohexane-1-carboxylate [1028]; 2-(1-isobutylpyrrolidin-3-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [1029]; trans-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-4-(4-methylpiperazine-1-carbonyl) cyclohexane-1-carboxamide [1030]; 1-isobutyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1031]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(phenylsulfonyl)piperidine-4-carboxamide [1032]; 8-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3,8-diazabicyclo[3.2.1]octane-3-carboxamide [1033]; 3-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxamide [1034]; (1R,3s,5S)-3-amino-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1035]; (1R,3s,5S)\u2014N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-((3,3,3-trifluoropropyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxamide [1036]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1037]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)morpholine-4-carboxamide [1038]; 4-(dimethylamino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-1-carboxamide [1039]; (S)-2,4-dimethyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperazine-1-carboxamide [1040]; 1-methyl-3-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)urea [1041]; 1-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(1-methylpiperidin-4-yl)urea [1042]; 4-isopropyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperazine-1-carboxamide [1043]; (R)-3,4-dimethyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)piperazine-1-carboxamide [1044]; N-(7-(1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1045]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(piperazin-1-yl)benzamide [1046]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(4-methylpiperazin-1-yl)benzamide [1047]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(pyrrolidin-1-ylmethyl)benzamide [1048]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(piperidin-4-yloxy)benzamide [1049]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [1050]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1051]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-4-((1-methylpiperidin-4-yl)oxy)benzamide [1052]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(piperazin-1-yl)isonicotinamide [1053]; [1054]; 2-(4-isopropylpiperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1055]; 2-(4-cyclopropylpiperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1056]; 2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1057]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [1058]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-5-(piperidin-4-yloxy)nicotinamide [1059]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-yloxy)isonicotinamide [1060]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-((1-methylpiperidin-4-yl)oxy) isonicotinamide [1061]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-5-(piperidin-4-ylamino)nicotinamide [1062]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-5-((1-methylpiperidin-4-yl)amino)nicotinamide [1063]; 2-(4-aminopiperidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1064]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methylamino)piperidin-1-yl) isonicotinamide [1065]; 2-(4-(dimethylamino)piperidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1066]; 2-((1-isopropylpiperidin-4-yl)oxy)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1067]; 2-(3-aminoazetidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1068]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1069]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-morpholinoisonicotinamide [1070]; 2-((2-(dimethylamino)ethyl)amino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1071]; 2-(2-(dimethylamino)ethoxy)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1072]; 2-(4-isobutylpiperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1073]; 2-(azetidin-3-yloxy)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1074]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-((1-methylazetidin-3-yl)oxy)isonicotinamide [1075]; 2-(4-ethylpiperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1076]; 4-((dimethylamino)methyl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)benzamide [1077]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(1-methylpiperidin-4-yl)benzamide [1078]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-((4-methylpiperazin-1-yl)methyl)benzamide [1079]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1080]; 2-hydroxy-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1081]; 2-isopropoxy-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1082]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(1-methylpiperidin-4-yl)isonicotinamide [1083]; 1\u2032-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [1084]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(6-(4-methylpiperazin-1-yl) nicotinoyl)piperazin-1-yl)isonicotinamide [1085]; 2-(4-hydroxy-4-methyl-4\u03bb 4 -piperazin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1086]; 2-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin-1-yl) isonicotinamide [1087]; 3-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1088]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1089]; 2-((2S,6R)-2,6-dimethylmorpholino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1090]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [1091]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [1092]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl) isonicotinamide [1093]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl) isonicotinamide [1094]; 2-(methyl(1-methylpiperidin-4-yl)amino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1095]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-((1-methylpiperidin-4-yl)thio) isonicotinamide [1096]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)pyrimidine-4-carboxamide [1097]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin-1-yl)pyridazine-4-carboxamide [1098]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin-1-yl)pyrimidine-4-carboxamide [1099]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-phenylacetamide [1100]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-phenylpropanamide [1101]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyridin-3-yl)acetamide [1102]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(pyridin-3-yl)propanamide [1103]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyridin-4-yl)acetamide [1104]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(pyridin-4-yl)propanamide [1105]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isoindoline-5-carboxamide [1106]; 2-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)isoindoline-5-carboxamide [1107]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [1108]; 2-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [1109]; 2-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide [1110]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide [1111]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-indole-5-carboxamide [1112]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)benzofuran-5-carboxamide [1113]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)furo[2,3-c]pyridine-5-carboxamide [1114]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)benzo[b]thiophene-5-carboxamide [1115]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)benzofuran-6-carboxamide [1116]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)benzo[d]oxazole-6-carboxamide [1117]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)benzo[d]thiazole-6-carboxamide [1118]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)benzo[d]oxazole-5-carboxamide [1119]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)benzo[d]thiazole-5-carboxamide [1120]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)quinoline-3-carboxamide [1121]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)quinoline-6-carboxamide [1122]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)quinoxaline-6-carboxamide [1123]; 5-chloro-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1124]; 3-chloro-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1125]; 2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1126]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)isonicotinamide [1127]; 3-fluoro-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1128]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-((4-methylpiperazin-1-yl)methyl) isonicotinamide [1129]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(morpholinomethyl)isonicotinamide [1130]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-ylmethyl)isonicotinamide [1131]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl) acetamide [1132]; 1-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-indazole-5-carboxamide [1133]; 1-methyl-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-benzo[d]imidazole-5-carboxamide [1134]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(piperidin-4-yl)-1H-pyrazole-4-carboxamide [1135]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [1136]; 1-(1-ethylpiperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1137]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1138]; 1-(1-isopropylpiperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1139]; 1-(1-cyclopropylpiperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1140]; isopropyl 4-(4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate [1141]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [1142]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [1143]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-1,2,3-triazole-4-carboxamide [1144]; 1-(1-isopropylpiperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-1,2,3-triazole-4-carboxamide [1145]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)oxazole-5-carboxamide [1146]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)oxazole-4-carboxamide [1147]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [1148]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [1149]; 2-(1-(2-fluoroethyl)piperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)oxazole-4-carboxamide [1150]; 2-(1-isopropylpiperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)oxazole-4-carboxamide [1151]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)oxazole-4-carboxamide [1152]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)thiazole-5-carboxamide [1153]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-yl)thiazole-4-carboxamide [1154]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)thiazole-4-carboxamide [1155]; 2-(1-(2-fluoroethyl)piperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)thiazole-4-carboxamide [1156]; 2-(1-isopropylpiperidin-4-yl)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)thiazole-4-carboxamide [1157]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(2-(methyl-d 3 )propyl-1,1,2,3,3,3-d 6 ) piperidine-4-carboxamide [1158]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d 4 )acetamide [1159]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methyl-d 3 )piperazin-1-yl)acetamide [1160]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(morpholino-d 8 )acetamide [1161]; (S)\u2014N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)propanamide [1162]; 1-isobutyl-N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1163]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide [1164]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1165]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-1-yl)acetamide [1166]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1167]; N-(7-(1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methyl-d 3 )piperazin-1-yl)isonicotinamide [1168]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methyl-d 3 )piperazin-1-yl)isonicotinamide [1169]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1170]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methyl-d 3 )piperazin-1-yl) isonicotinamide [1171]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(piperidin-4-yl)-1H-pyrazole-4-carboxamide [1172]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [1173]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [1174]; N-(7-(1-(methyl-d 3 )-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [1175]; N-(7-(1-ethyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1176]; N-(7-(1-cyclopropyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1177]; N-(7-(1-cyclopropyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1178]; N-(7-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexanecarboxamide [1179]; 2-(pyrrolidin-1-yl)-N-(7-(5-(trifluoromethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)acetamide [1180]; N-(7-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1181]; N-(7-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)tetrahydro-2H-pyran-4-carboxamide [1182]; N-(7-(5-(azetidin-1-ylmethyl)-1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-4,4-difluorocyclohexane-1-carboxamide [1183]; 4,4-difluoro-N-(7-(1-methyl-5-(pyrrolidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl) cyclohexane-1-carboxamide [1184]; 4,4-difluoro-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl) cyclohexane-1-carboxamide [1185]; 2-(2-fluoroethyl)-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)-2-azaspiro[3.3]heptane-6-carboxamide [1186]; tert-butyl 6-((7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)-2-azaspiro[3.3]heptane-2-carboxylate [1187]; 2-fluoro-2-methyl-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl) propanamide [1188]; 2-(diethylamino)-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl) acetamide [1189]; trans-4-methoxy-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl) cyclohexane-1-carboxamide [1190]; trans-4-(hydroxymethyl)-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1191]; (R)\u2014N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)pyrrolidine-2-carboxamide [1192]; 1-isobutyl-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1193]; N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)-1-(oxetan-3-yl) piperidine-4-carboxamide [1194]; 1-benzoyl-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1195]; N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)tetrahydro-2H-pyran-4-carboxamide [1196]; N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperidin-1-yl)acetamide [1197]; N-(7-(1-(difluoromethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1198]; N-(7-(1-ethyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1199]; N-(7-(1-isopropyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(piperidin-4-yloxy)benzamide [1200]; N-(7-(1-isopropyl-1H-pyrazol-4-yl)quinazolin-2-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [1201]; N-(7-(1-isopropyl-1H-pyrazol-4-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1202]; N-(7-(1-cyclopropyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1203]; 4-fluoro-N-(7-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)quinazolin-2-yl)benzamide [1204]; 4-(difluoromethoxy)-N-(7-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)quinazolin-2-yl) benzamide [1205]; 5-fluoro-N-(7-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)quinazolin-2-yl)nicotinamide [1206]; N 2 -methyl-N 5 -(7-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)quinazolin-2-yl)pyridine-2,5-dicarboxamide [1207]; 1-isopropyl-N-(7-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1208]; 2-methyl-N-(7-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)quinazolin-2-yl)thiazole-5-carboxamide [1209]; N-(7-(5-amino-1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1210]; 4-(difluoromethoxy)-N-(7-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl) benzamide [1211]; N-(7-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1212]; N-(7-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(7-methyl-2,7-diazaspiro [3.5]nonan-2-yl)isonicotinamide [1213]; 4-fluoro-N-(7-(1-methyl-5-(pyrrolidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)benzamide [1214]; 4-fluoro-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)benzamide [1215]; 4-(difluoromethoxy)-N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl) benzamide [1216]; N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)-3-(pyrrolidin-1-ylmethyl)benzamide [1217]; N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [1218]; N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)-2-morpholinoisonicotinamide [1219]; N-(7-(1-methyl-5-(morpholinomethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)-2-morpholinoisonicotinamide [1220]; N-(7-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)-1-((1-(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [1221]; 3,3-difluoro-N-(7-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl) cyclobutane-1-carboxamide [1222]; N-((4,4-difluorocyclohexyl)methyl)-7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-amine [1223]; N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)-11-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [1224]; N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1225]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)acetamide [1226]; (R)\u2014N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)-1-isobutylpiperidine-3-carboxamide [1227]; N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)piperidine-4-carboxamide [1228]; 4-fluoro-N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)-1-isobutylpiperidine-4-carboxamide [1229]; N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide [1230]; 4-fluoro-N-(7-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)benzamide [1231]; N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)-3-(4-methylpiperazin-1-yl)benzamide [1232]; N 5 -(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)-N 2 -methylpyridine-2,5-dicarboxamide [1233]; N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)quinazolin-2-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [1234]; 2-(azetidin-3-yloxy)-N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl) quinazolin-2-yl)isonicotinamide [1235]; N-(7-(1-methyl-1H-pyrazol-5-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1236]; 1-methyl-N-(7-(1-methyl-1H-pyrazol-3-yl)quinazolin-2-yl)piperidine-4-carboxamide [1237]; N-(7-(1-methyl-1H-pyrazol-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1238]; 2-fluoro-2-methyl-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)propanamide [1239]; 2,2,3,3-tetramethyl-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)cyclopropane-1-carboxamide [1240]; trans-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-4-(pyrrolidin-1-yl)cyclohexane-1-carboxamide [1241]; trans-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-4-morpholinocyclohexane-1-carboxamide [1242]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(piperidin-1-yl)acetamide [1243]; 1-ethyl-4-fluoro-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1244]; 4-fluoro-1-isobutyl-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1245]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1246]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)cyclopropanecarboxamide [1247]; 4,4-difluoro-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1248]; trans-4-(dimethylamino)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1249]; trans-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [1250]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1251]; 1-isobutyl-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1252]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1-((1-(trifluoromethyl)cyclopropyl) methyl)piperidine-4-carboxamide [1253]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1-((3-methyloxetan-3-yl)methyl) piperidine-4-carboxamide [1254]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [1255]; 1\u2032-methyl-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [1256]; (R)\u2014N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [1257]; (R)-1-isobutyl-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [1258]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1259]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide [1260]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl) acetamide [1261]; 1-(2-hydroxy-2-methylpropyl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1262]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-morpholinoacetamide [1263]; 2-(4-methoxypiperidin-1-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)acetamide [1264]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)morpholine-4-carboxamide [1265]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1-(piperidin-4-yl)-1H-pyrazole-4-carboxamide [1266]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [1267]; 1-(1-ethylpiperidin-4-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1268]; 1-(1-isopropylpiperidin-4-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1269]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [1270]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1H-1,2,3-triazole-4-carboxamide [1271]; 1-(1-isopropylpiperidin-4-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1H-1,2,3-triazole-4-carboxamide [1272]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [1273]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [1274]; 2-(1-isopropylpiperidin-4-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)oxazole-4-carboxamide [1275]; 2-fluoro-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)benzamide [1276]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [1277]; N 2 -methyl-N 5 -(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)pyridine-2,5-dicarboxamide [1278]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [1279]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl) isonicotinamide [1280]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(1-methylpiperidin-4-yl)isonicotinamide [1281]; 2-(4-(dimethylamino)piperidin-1-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl) isonicotinamide [1282]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-morpholinoisonicotinamide [1283]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1284]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl) isonicotinamide [1285]; 2-(4-isopropylpiperazin-1-yl)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl) isonicotinamide [1286]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-ylamino)isonicotinamide [1287]; 2-(methyl(1-methylpiperidin-4-yl)amino)-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl) isonicotinamide [1288]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-((1-methylpiperidin-4-yl)thio) isonicotinamide [1289]; 2-methyl-N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide [1290]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(piperazin-1-yl)isonicotinamide [1291]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl) acetamide [1292]; 1,1-bis(methyl-d 3 )-4-(4-((7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)carbamoyl)pyridin-2-yl)piperazin-1-ium [1293]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-2-(4-(methyl-d 3 )piperazin-1-yl) isonicotinamide [1294]; N-(7-(1-methyl-1H-1,2,3-triazol-5-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1295]; N-(7-(4-methyl-4H-1,2,4-triazol-3-yl)quinazolin-2-yl)-2-morpholinoacetamide [1296]; N-(7-(4-methyl-4H-1,2,4-triazol-3-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1297]; 4-fluoro-1-isobutyl-N-(7-(4-methyl-4H-1,2,4-triazol-3-yl)quinazolin-2-yl)piperidine-4-carboxamide [1298]; N-(7-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)quinazolin-2-yl)-2-morpholinoacetamide [1299]; N-(7-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1300]; N-(7-(1H-1,2,3-triazol-1-yl)quinazolin-2-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [1301]; N-(7-(2H-1,2,3-triazol-2-yl)quinazolin-2-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [1302]; N-(7-(1H-1,2,4-triazol-1-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1303]; 1-isobutyl-N-(7-(1-methyl-1H-tetrazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1304]; 2,2,3,3-tetramethyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)cyclopropane-1-carboxamide [1305]; 4,4-difluoro-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1306]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(piperidin-1-yl)acetamide [1307]; 2-fluoro-2-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)propanamide [1308]; 1-fluoro-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)cyclopropane-1-carboxamide [1309]; 2-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-azaspiro[3.3]heptane-6-carboxamide [1310]; 1-fluoro-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1311]; trans-4-methoxy-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1312]; trans-4-(hydroxymethyl)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1313]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)azetidine-3-carboxamide [1314]; (R)\u2014N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)tetrahydrofuran-2-carboxamide [1315]; 1-(2-methoxyethyl)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1316]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1317]; 1-isobutyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1318]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [1319]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)propanamide [1320]; 2-isopropoxy-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)acetamide [1321]; 3-isopropoxy-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)propanamide [1322]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)cyclopropanecarboxamide [1323]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)cyclohexanecarboxamide [1324]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4,4-difluorocyclohexane-1-carboxamide [1325]; (S)\u2014N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)tetrahydrofuran-2-carboxamide [1326]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-3,3-difluorocyclobutane-1-carboxamide [1327]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-1-fluorocyclopropane-1-carboxamide [1328]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)morpholine-4-carboxamide [1329]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)morpholine-d 8 -4-carboxamide [1330]; 1-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1331]; 1-ethyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1332]; 1-isopropyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1333]; 1-cyclopropyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1334]; 1-isobutyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1335]; 1-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-pyrazole-3-carboxamide [1336]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)acetamide [1337]; 1-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-imidazole-4-carboxamide [1338]; 1-isopropyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-imidazole-4-carboxamide [1339]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazole-4-carboxamide [1340]; 1,2-dimethyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-imidazole-5-carboxamide [1341]; 1-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-1,2,4-triazole-3-carboxamide [1342]; 2-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)oxazole-4-carboxamide [1343]; 2-isopropyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)oxazole-4-carboxamide [1344]; 4-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)oxazole-2-carboxamide [1345]; 4-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)thiazole-2-carboxamide [1346]; 2-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)thiazole-4-carboxamide [1347]; 5-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1,3,4-oxadiazole-2-carboxamide [1348]; 5-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-1,3,4-thiadiazole-2-carboxamide [1349]; 1-isopropyl-N-(7-(1-isopropyl-1H-imidazol-5-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1350]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-1-methyl-1H-pyrazole-4-carboxamide [1351]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-1-isopropyl-1H-pyrazole-4-carboxamide [1352]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-methylthiazole-5-carboxamide [1353]; 4-fluoro-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide [1354]; 4-(difluoromethoxy)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide [1355]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-3-(pyrrolidin-1-ylmethyl)benzamide [1356]; 2-fluoro-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-3,4,5,6-d 4  [1357]; 4-fluoro-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-d 4  [1358]; 2-chloro-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-3,4,5,6-d 4  [1359]; 4-chloro-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-d 4  [1360]; 4-(methyl-d 3 )-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide [1361]; 4-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-d 4  [1362]; 4-(methyl-d 3 )-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-d 4  [1363]; 4-(methoxy-d 3 )-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide [1364]; 4-(methoxy-d 3 )-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-d 4  [1365]; 4-methoxy-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-d 4  [1366]; (E)-N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide [1367]; (E)-N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide-2,3-d 2  [1368]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(4-fluorophenyl)acetamide-2,2-d 2  [1369]; (E)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide [1370]; (E)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide-2,3-d 2  [1371]; 2-(4-fluorophenyl)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)acetamide-2,2-d2 [1372]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1373]; 2-(dimethylamino)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1374]; 2-(3-aminoazetidin-1-yl)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1375]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)isonicotinamide [1376]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(piperidin-1-yl)isonicotinamide [1377]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-morpholinoisonicotinamide [1378]; 2-(4-isopropylpiperazin-1-yl)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1379]; 2-(4-cyclopropylpiperazin-1-yl)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl) isonicotinamide [1380]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [1381]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [1382]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isoindoline-5-carboxamide [1383]; 2-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isoindoline-5-carboxamide [1384]; 2-(azetidin-1-yl)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1385]; 2-methoxy-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1386]; 2-methyl-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1387]; 2-cyano-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1388]; 2-(3,3-difluoroazetidin-1-yl)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1389]; 2-(4,4-difluoropiperidin-1-yl)-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1390]; 2-isopropoxy-N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1391]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d 4 )isonicotinamide [1392]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl-d 8 )isonicotinamide [1393]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(piperidin-1-yl-d 10 )isonicotinamide [1394]; N-(7-(1-methyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(morpholino-d 8 )isonicotinamide [1395]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4-isopropoxybenzamide [1396]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1397]; 4-(benzyloxy)-N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide [1398]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-fluorobenzamide-3,4,5,6-d 4  [1399]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4-fluorobenzamide-2,3,5,6-d 4  [1400]; 2-chloro-N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-3,4,5,6-d 4  [1401]; 4-chloro-N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-d 4  [1402]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4-(methyl-d 3 )benzamide [1403]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4-methylbenzamide-2,3,5,6-d 4  [1404]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4-(methyl-d 3 )benzamide-2,3,5,6-d 4  [1405]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4-(methoxy-d 3 )benzamide [1406]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4-(methoxy-d 3 )benzamide-2,3,5,6-d 4  [1407]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-4-methoxybenzamide-2,3,5,6-d 4  [1408]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1409]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-morpholinoisonicotinamide [1410]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)isonicotinamide [1411]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(dimethylamino)isonicotinamide [1412]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d 4 ) isonicotinamide [1413]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl-d 8 )isonicotinamide [1414]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(piperidin-1-yl-d 10 )isonicotinamide [1415]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(morpholino-d 8 )isonicotinamide [1416]; N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide [1417]; N-(7-(7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl) cyclopropanecarboxamide [1418]; 3,3-difluoro-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)cyclobutane-1-carboxamide [1419]; (R)\u2014N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)pyrrolidine-2-carboxamide [1420]; (R)\u2014N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)piperidine-3-carboxamide [1421]; 1-methyl-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)piperidine-4-carboxamide [1422]; N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)-1-((1-(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [1423]; 1-benzoyl-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)piperidine-4-carboxamide [1424]; 4-fluoro-1-isobutyl-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl) piperidine-4-carboxamide [1425]; (R)-2-(2-methylpyrrolidin-1-yl)-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)acetamide [1426]; 2-(cyclobutyl(methyl)amino)-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)acetamide [1427]; 4-fluoro-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)benzamide [1428]; 4-isopropoxy-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl)benzamide [1429]; 4-(difluoromethoxy)-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl) benzamide [1430]; 2-((2-(dimethylamino)ethyl)amino)-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl) quinazolin-2-yl)isonicotinamide [1431]; 2-((1-isopropylpiperidin-4-yl)oxy)-N-(7-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl) quinazolin-2-yl)isonicotinamide [1432]; N-(7-(oxazol-5-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1433]; N-(7-(oxazol-5-yl)quinazolin-2-yl)cyclopropanecarboxamide [1434]; (R)\u2014N-(7-(oxazol-5-yl)quinazolin-2-yl)tetrahydrofuran-2-carboxamide [1435]; (R)\u2014N-(7-(oxazol-5-yl)quinazolin-2-yl)piperidine-3-carboxamide [1436]; N-(7-(oxazol-5-yl)quinazolin-2-yl)tetrahydro-2H-pyran-4-carboxamide [1437]; N-(7-(oxazol-5-yl)quinazolin-2-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [1438]; 1\u2032-methyl-N-(7-(oxazol-5-yl)quinazolin-2-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [1439]; cis-4-morpholino-N-(7-(oxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1440]; 2-(cyclobutyl(methyl)amino)-N-(7-(oxazol-5-yl)quinazolin-2-yl)acetamide [1441]; N-(7-(oxazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1442]; (R)-2-(2-methylpyrrolidin-1-yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)acetamide [1443]; 2-(4-methylpiperazin-1-yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)acetamide [1444]; trans-4-((4-methylpiperazin-1-yl)methyl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1445]; 1-(2,2-difluoropropyl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1446]; trans-4-(hydroxymethyl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1447]; trans-4-(methylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1448]; trans-4-((1,3-difluoropropan-2-yl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl) cyclohexane-1-carboxamide [1449]; trans-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-4-((propan-2-yl-1,1,1,3,3,3-d 6 )amino) cyclohexane-1-carboxamide [1450]; trans-4-((2,2-difluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1451]; trans-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-4-((3,3,3-trifluoropropyl)amino)cyclohexane-1-carboxamide [1452]; trans-4-((2-methoxyethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1453]; trans-4-(dimethylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1454]; trans-4-(bis(methyl-d 3 )amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1455]; cis-4-(dimethylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1456]; trans-4-((2,2-difluoroethyl)(methyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl) cyclohexane-1-carboxamide [1457]; trans-4-(methyl(oxetan-3-yl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1458]; trans-4-((2-fluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1459]; trans-4-(2-(fluoromethyl)aziridin-1-yl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1460]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1461]; trans-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-3-morpholinocyclobutane-1-carboxamide [1462]; trans-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-4-morpholinocyclohexane-1-carboxamide [1463]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-(piperidin-1-yl)acetamide [1464]; 2-(4-methoxypiperidin-1-yl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)acetamide [1465]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide [1466]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)morpholine-4-carboxamide [1467]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-morpholinoacetamide [1468]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-3-morpholinopropanamide [1469]; 1-methyl-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1470]; 1-(2,2-difluoropropyl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1471]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-4-morpholinopiperidine-1-carboxamide [1472]; 4-((1,3-difluoropropan-2-yl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1473]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1474]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1475]; 4-(dimethylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1476]; 4-((2,2-difluoroethyl)(methyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1477]; (3S,4S)-4-amino-3-fluoro-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1478]; (3S,4S)-3-fluoro-4-(methylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1479]; (3R,4R)-4-amino-3-fluoro-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1480]; (3R,4R)-3-fluoro-4-(methylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1481]; 4-((2-fluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1482]; 4-((2,2-difluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1483]; (1R,3s,5S)-3-amino-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1484]; (1R,3r,5S)-3-amino-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1485]; (1R,3r,5S)-3-((2-fluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1486]; (1R,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1487]; (1R,3s,5S)\u2014N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-3-((3,3,3-trifluoropropyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxamide [1488]; (3S,4S)-3-fluoro-4-(isopropylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1489]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [1490]; 2-methyl-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [1491]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-(morpholino-d 8 )acetamide [1492]; trans-N-(7-(2-methyloxazol-4-yl)quinazolin-2-yl)-4-(4-methylpiperazin-1-yl)cyclohexane-1-carboxamide [1493]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [1494]; 2-(1H-imidazol-1-yl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)acetamide [1495]; 4-(difluoromethoxy)-N-(7-(oxazol-5-yl)quinazolin-2-yl)benzamide [1496]; 3-((1-methylpiperidin-4-yl)oxy)-N-(7-(oxazol-5-yl)quinazolin-2-yl)benzamide [1497]; N-(7-(oxazol-5-yl)quinazolin-2-yl)isonicotinamide [1498]; 2-(3-aminoazetidin-1-yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)isonicotinamide [1499]; 2-(1-methylpiperidin-4-yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)isonicotinamide [1500]; 1\u2032-methyl-N-(7-(oxazol-5-yl)quinazolin-2-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [1501]; 2-(4-methylpiperazin-1-yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)isonicotinamide [1502]; 2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)isonicotinamide [1503]; N-(7-(oxazol-5-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide [1504]; N-(7-(oxazol-5-yl)quinazolin-2-yl)-2-(piperidin-4-ylamino)isonicotinamide [1505]; 2-methyl-N-(7-(oxazol-5-yl)quinazolin-2-yl)isoindoline-5-carboxamide [1506]; N-(7-(oxazol-5-yl)quinazolin-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [1507]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1508]; N-(7-(3-methylisoxazol-5-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1509]; 4-fluoro-1-isobutyl-N-(7-(5-methyl-1,3,4-oxadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1510]; 1-isobutyl-N-(7-(5-methyl-1,3,4-oxadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1511]; N-(7-(5-(dimethylamino)-1,3,4-oxadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1512]; N-(7-(5-(dimethylamino)-1,3,4-oxadiazol-2-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1513]; N-(7-(5-methyl-1,3,4-oxadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1514]; 3,3-difluoro-N-(7-(thiazol-5-yl)quinazolin-2-yl)cyclobutane-1-carboxamide [1515]; 2-methyl-N-(7-(thiazol-5-yl)quinazolin-2-yl)-2-azaspiro[3.3]heptane-6-carboxamide [1516]; 1-fluoro-N-(7-(thiazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1517]; trans-4-(dimethylamino)-N-(7-(thiazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1518]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1519]; N-(7-(thiazol-5-yl)quinazolin-2-yl)azetidine-3-carboxamide [1520]; 1-methyl-N-(7-(thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1521]; 1-(2,2-difluoropropyl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1522]; 1-(oxetan-3-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1523]; 1-(2-(pyrrolidin-1-yl)acetyl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1524]; 1\u2032-methyl-N-(7-(thiazol-5-yl)quinazolin-2-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [1525]; 2-(pyrrolidin-1-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)propanamide [1526]; 2-(piperidin-1-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)acetamide [1527]; 2-(4-methylpiperazin-1-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)acetamide [1528]; 2-morpholino-N-(7-(thiazol-5-yl)quinazolin-2-yl)acetamide [1529]; 4-(piperidin-4-yloxy)-N-(7-(thiazol-5-yl)quinazolin-2-yl)benzamide [1530]; N-(7-(thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1531]; 6-(4-methylpiperazin-1-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)nicotinamide [1532]; 1\u2032-methyl-N-(7-(thiazol-5-yl)quinazolin-2-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [1533]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1534]; 2-(4-(dimethylamino)piperidin-1-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1535]; 2-(4-methylpiperazin-1-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1536]; 2-((1-methylpiperidin-4-yl)thio)-N-(7-(thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1537]; N-(7-(thiazol-5-yl)quinazolin-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [1538]; trans-4-((1,3-difluoropropan-2-yl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) cyclohexane-1-carboxamide [1539]; N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)morpholine-4-carboxamide [1540]; N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1541]; 2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl) acetamide [1542]; N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)-2-morpholinoacetamide [1543]; N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)-2-(morpholino-d 8 )acetamide [1544]; 2-(4-methylpiperazin-1-yl)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)acetamide [1545]; 1-methyl-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1546]; N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)isonicotinamide [1547]; N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)nicotinamide [1548]; 2-(4-methylpiperazin-1-yl)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)isonicotinamide [1549]; trans-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-morpholinocyclohexane-1-carboxamide [1550]; trans-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(4-methylpiperazin-1-yl) cyclohexane-1-carboxamide [1551]; 4-isopropyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperazine-1-carboxamide [1552]; 4-((2-methoxyethyl)(methyl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-1-carboxamide [1553]; 4-((1,3-difluoropropan-2-yl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-1-carboxamide [1554]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-((3,3,3-trifluoropropyl)amino)piperidine-1-carboxamide [1555]; 4-((2-fluoroethyl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-1-carboxamide [1556]; (3R,4S)-4-amino-3-fluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-1-carboxamide [1557]; (3R,4R)-4-amino-3-fluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-1-carboxamide [1558]; (3S,4S)-3-fluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(methylamino) piperidine-1-carboxamide [1559]; (3R,4R)-3-fluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(methylamino) piperidine-1-carboxamide [1560]; 4-amino-3,3-difluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-1-carboxamide [1561]; (3R,4R)-3-fluoro-4-(isopropylamino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-1-carboxamide [1562]; (3R,4S)-3-fluoro-4-(isopropylamino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-1-carboxamide [1563]; 3,3-difluoro-4-(isopropylamino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-1-carboxamide [1564]; (3S,4S)-3-fluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-((propan-2-yl-1,1,1,3,3,3-d 6 )amino)piperidine-1-carboxamide [1565]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1566]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1567]; 4-(dimethylamino)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [1568]; 4-((2,2-difluoroethyl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-1-carboxamide [1569]; 4-((2,2-difluoroethyl)(methyl-d 3 )amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-1-carboxamide [1570]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-morpholinopiperidine-1-carboxamide [1571]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(4-methylpiperazin-1-yl)piperidine-1-carboxamide [1572]; (R)-3,4-dimethyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperazine-1-carboxamide [1573]; (S)-3,4-dimethyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperazine-1-carboxamide [1574]; (1R,3r,5S)-3-((2-fluoroethyl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1575]; (1R,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1576]; (1R,3r,5S)-3-amino-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1577]; (1S,4S)-5-methyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxamide [1578]; (1R,4R)-5-methyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxamide [1579]; 8-methyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-3,8-diazabicyclo[3.2.1]octane-3-carboxamide [1580]; 3-methyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxamide [1581]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [1582]; 2-(4-methylpiperazin-1-yl)-N-(7-(5-methylthiazol-2-yl)quinazolin-2-yl)isonicotinamide [1583]; 2-(4-methylpiperazin-1-yl)-N-(7-(4-methylthiazol-2-yl)quinazolin-2-yl)isonicotinamide [1584]; N-(7-(2-(methylamino)thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1585]; 1-methyl-N-(7-(2-(methylamino)thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1586]; N-(7-(2-(diethylamino)thiazol-5-yl)quinazolin-2-yl)-2-(4-fluoropiperidin-1-yl)acetamide [1587]; N-(7-(2-(diethylamino)thiazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide [1588]; N-(7-(2-aminothiazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1589]; N-(7-(2-(methylamino)thiazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1590]; N-(7-(2-(dimethylamino)thiazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1591]; 2-(4-isopropylpiperazin-1-yl)-N-(7-(2-(methylamino)thiazol-5-yl)quinazolin-2-yl) isonicotinamide [1592]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(7-(2-(methylamino)thiazol-5-yl)quinazolin-2-yl) isonicotinamide [1593]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(7-(2-(dimethylamino)thiazol-5-yl)quinazolin-2-yl) isonicotinamide [1594]; 2-(3-aminoazetidin-1-yl)-N-(7-(2-(dimethylamino)thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1595]; N-(7-(5-chlorothiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1596]; 2-(2-(2-(4-methylpiperazin-1-yl)isonicotinamido)quinazolin-7-yl)thiazole-5-carboxamide [1597]; N-(7-(isothiazol-4-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1598]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(difluoromethoxy)benzamide [1599]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1600]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-((1-methylpiperidin-4-yl)oxy)benzamide [1601]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [1602]; N 5 -(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-N 2 -methylpyridine-2,5-dicarboxamide [1603]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [1604]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-1\u2032-methyl-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [1605]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(3-(dimethylamino)azetidin-1-yl)isonicotinamide [1606]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1607]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(4-isopropylpiperazin-1-yl)isonicotinamide [1608]; N-(7-(1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-morpholinoisonicotinamide [1609]; 1-fluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1610]; trans-4-methoxy-N-(7-(5-methyl-1,34-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1611]; cis-4-methoxy-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1612]; trans-4-amino-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1613]; trans-4-(dimethylamino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1614]; trans-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-morpholinocyclohexane-1-carboxamide [1615]; trans-4-(hydroxymethyl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1616]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1617]; 4-fluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1618]; 1-methyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1619]; 4-fluoro-1-methyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1620]; 1-(2-fluoroethyl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1621]; 1-(2,2-difluoroethyl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1622]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1623]; 1-(2,2-difluoropropyl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1624]; 1-benzoyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1625]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1626]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(piperidin-1-yl)acetamide [1627]; 2-(4-methoxypiperidin-1-yl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)acetamide [1628]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide [1629]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-morpholinoacetamide [1630]; (R)\u2014N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(3-methylmorpholino)acetamide [1631]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) acetamide [1632]; 2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl) quinazolin-2-yl)acetamide [1633]; 2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) acetamide [1634]; 2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) acetamide [1635]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(1,4-oxazepan-4-yl)acetamide [1636]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-morpholinoacetamide-2,2-d 2  [1637]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(morpholino-d 8 )acetamide [1638]; 1-methyl-3-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)urea [1639]; (3S,4S)-4-amino-3-fluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-1-carboxamide [1640]; (3S,4S)-4-(dimethylamino)-3-fluoro-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-1-carboxamide [1641]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)morpholine-4-carboxamide [1642]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(methylamino)piperidine-1-carboxamide [1643]; 4-(dimethylamino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-1-carboxamide [1644]; 4-((2,2-difluoroethyl)(methyl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-1-carboxamide [1645]; (3S,4S)-3-fluoro-4-(isopropylamino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-1-carboxamide [1646]; 2-methyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [1647]; 4-methyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperazine-1-carboxamide [1648]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [1649]; 1-(1-isopropylpiperidin-4-yl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1650]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [1651]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [1652]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [1653]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) isonicotinamide [1654]; 1\u2032-methyl-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [1655]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1656]; 2-(methyl(1-methylpiperidin-4-yl)amino)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) isonicotinamide [1657]; 2-(azetidin-3-yloxy)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)isonicotinamide [1658]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [1659]; N-(7-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-((1-methylpiperidin-4-yl)thio) isonicotinamide [1660]; 6-(4-methylpiperazin-1-yl)-N-(7-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) nicotinamide [1661]; 2-(4-methylpiperazin-1-yl)-N-(7-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)quinazolin-2-yl) isonicotinamide [1662]; N-(7-(5-amino-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1663]; N-(7-(5-(dimethylamino)-1,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1664]; N-(7-(3-amino-5-fluorophenyl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1665]; N-(7-(3-fluoro-5-(isopropylamino)phenyl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1666]; 1-methyl-N-(7-(pyridin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1667]; 2-(4-methylpiperazin-1-yl)-N-(7-(pyridin-2-yl)quinazolin-2-yl)isonicotinamide [1668]; 2-(4-methylpiperazin-1-yl)-N-(7-(pyridin-4-yl)quinazolin-2-yl)isonicotinamide [1669]; N-(7-(pyridin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide [1670]; N-(7-(pyridin-3-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1671]; 1-methyl-N-(7-(pyridin-3-yl)quinazolin-2-yl)piperidine-4-carboxamide [1672]; N-(7-(pyridin-3-yl)quinazolin-2-yl)quinuclidine-4-carboxamide [1673]; 2-morpholino-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1674]; 2-(morpholino-d 8 )-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1675]; 2-(4-methylpiperazin-1-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1676]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1677]; 2-(4-methylpiperazin-1-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)isonicotinamide [1678]; 2-(2-methyl-1H-imidazol-1-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1679]; 2-(1H-imidazol-1-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1680]; 2-(piperidin-4-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)oxazole-4-carboxamide [1681]; 2-(1-methylpiperidin-4-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)oxazole-4-carboxamide [1682]; 2-(1-isopropylpiperidin-4-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)oxazole-4-carboxamide [1683]; trans-N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-3-morpholinocyclobutane-1-carboxamide [1684]; trans-N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [1685]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1686]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1687]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide [1688]; N-(7-(6-fluoropyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide [1689]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-morpholinoacetamide [1690]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-3-morpholinopropanamide [1691]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1692]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [1693]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [1694]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(1-isopropylpiperidin-4-yl)oxazole-4-carboxamide [1695]; N-(7-(5-chloropyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1696]; N-(7-(5-methylpyridin-3-yl)quinazolin-2-yl)-2-morpholinoacetamide [1697]; N-(7-(5-(difluoromethyl)pyridin-3-yl)quinazolin-2-yl)-3-(piperidin-4-yl)benzamide [1698]; N-(7-(5-(difluoromethyl)pyridin-3-yl)quinazolin-2-yl)-3-(1-methylpiperidin-4-yl)benzamide [1699]; N-(7-(5-(difluoromethyl)pyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1700]; 2-(4-methylpiperazin-1-yl)-N-(7-(5-(trifluoromethyl)pyridin-3-yl)quinazolin-2-yl)acetamide [1701]; 2-(4-methylpiperazin-1-yl)-N-(7-(6-(trifluoromethyl)pyridin-3-yl)quinazolin-2-yl)acetamide [1702]; N-(7-(5-(hydroxymethyl)pyridin-3-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1703]; N-(7-(5-cyanopyridin-3-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1704]; N-(7-(5-methoxypyridin-3-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1705]; N-(7-(5-methoxypyridin-3-yl)quinazolin-2-yl)-2-morpholinoacetamide [1706]; N-(7-(5-methoxypyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1707]; 4-fluoro-N-(7-(5-(piperidin-4-yloxy)pyridin-3-yl)quinazolin-2-yl)benzamide [1708]; N-(7-(5-aminopyridin-3-yl)quinazolin-2-yl)-4-fluorobenzamide [1709]; N-(7-(5-aminopyridin-3-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1710]; N-(7-(5-aminopyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1711]; N-(7-(5-aminopyridin-3-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [1712]; N-(7-(6-aminopyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1713]; N-(7-(6-(methylamino)pyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1714]; N-(7-(5-(isopropylamino)pyridin-3-yl)quinazolin-2-yl)-3-(piperidin-4-yl)benzamide [1715]; N-(7-(5-(isopropylamino)pyridin-3-yl)quinazolin-2-yl)-3-(1-methylpiperidin-4-yl)benzamide [1716]; N-(7-(5-(isopropylamino)pyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1717]; N-(7-(5-(piperidin-4-ylamino)pyridin-3-yl)quinazolin-2-yl)cyclohexanecarboxamide [1718]; 4-fluoro-N-(7-(5-(piperidin-4-ylamino)pyridin-3-yl)quinazolin-2-yl)benzamide [1719]; 4-fluoro-N-(7-(5-((1-methylpiperidin-4-yl)amino)pyridin-3-yl)quinazolin-2-yl)benzamide [1720]; N-(7-(5-acetamidopyridin-3-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1721]; N-(7-(5-(dimethylamino)pyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1722]; N-(7-(6-(dimethylamino)pyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1723]; 1-methyl-N-(7-(5-(pyrrolidin-1-yl)pyridin-3-yl)quinazolin-2-yl)piperidine-4-carboxamide [1724]; N-(7-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide [1725]; 4-fluoro-N-(7-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)quinazolin-2-yl)benzamide [1726]; N-(7-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)quinazolin-2-yl) cyclopropanecarboxamide [1727]; 4-fluoro-N-(7-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)quinazolin-2-yl)benzamide [1728]; N-(7-(5-(piperazin-1-ylmethyl)pyridin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide [1729]; N-(7-(5-((4-methylpiperazin-1-yl)methyl)pyridin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide [1730]; N-(7-(5-(morpholinomethyl)pyridin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide [1731]; N-methyl-5-(2-(1-methylpiperidine-4-carboxamido)quinazolin-7-yl)nicotinamide [1732]; N-methyl-5-(2-(2-(4-methylpiperazin-1-yl)isonicotinamido)quinazolin-7-yl)nicotinamide [1733]; N-(7-(pyridin-3-yl-d 4 )quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1734]; 2-(4-methylpiperazin-1-yl)-N-(7-(pyridin-3-yl-d 4 )quinazolin-2-yl)acetamide [1735]; 2-morpholino-N-(7-(pyridin-3-yl-d 4 )quinazolin-2-yl)acetamide [1736]; 1-methyl-N-(7-(2-methylpyrimidin-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1737]; 2-(4-methylpiperazin-1-yl)-N-(7-(2-methylpyrimidin-5-yl)quinazolin-2-yl)isonicotinamide [1738]; N-(7-(2-aminopyrimidin-5-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1739]; 2-morpholino-N-(7-(pyridazin-3-yl)quinazolin-2-yl)acetamide [1740]; 2-morpholino-N-(7-(pyridazin-4-yl)quinazolin-2-yl)acetamide [1741]; N-(7-(pyridazin-4-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1742]; trans-3-morpholino-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclobutane-1-carboxamide [1743]; trans-4-(dimethylamino)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1744]; trans-4-morpholino-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1745]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1746]; trans-4-((4-methylpiperazin-1-yl)methyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1747]; N-(7-(pyrazin-2-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)acetamide [1748]; 1-methyl-N-(7-(pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1749]; 4-fluoro-1-methyl-N-(7-(pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1750]; 1-(2-fluoroethyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1751]; 1-(oxetan-3-yl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1752]; 2-morpholino-N-(7-(pyrazin-2-yl)quinazolin-2-yl)acetamide [1753]; 1-methyl-N-(7-(pyrazin-2-yl)quinazolin-2-yl)azepane-4-carboxamide [1754]; 1-isobutyl-N-(7-(pyrazin-2-yl)quinazolin-2-yl)azepane-4-carboxamide [1755]; 1-(2-hydroxy-2-methylpropyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)azepane-4-carboxamide [1756]; 4-(morpholinomethyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)benzamide [1757]; 2-(4-methylpiperazin-1-yl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)isonicotinamide [1758]; N-(7-(6-(methylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1759]; N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)azetidine-3-carboxamide [1760]; N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1761]; N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-1-methylpiperidine-4-carboxamide [1762]; 1-(2-fluoroethyl)-N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1763]; 1-isopropyl-N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1764]; 1-isopentyl-N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1765]; N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-3-(piperidin-4-yl)benzamide [1766]; N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-3-(1-methylpiperidin-4-yl)benzamide [1767]; N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [1768]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-1H-1,2,3-triazole-4-carboxamide [1769]; N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-1-(1-isopropylpiperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [1770]; N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1771]; N-(7-(6-(tert-butylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(3-(dimethylamino)azetidin-1-yl) isonicotinamide [1772]; N-(7-(6-(tert-butylamino)pyrazin-2-yl)quinazolin-2-yl)-1\u2032-methyl-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [1773]; N-(7-(6-(tert-butylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1774]; N-(7-(6-(tert-butylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-isopropylpiperazin-1-yl) isonicotinamide [1775]; N-(7-(6-(tert-butylamino)pyrazin-2-yl)quinazolin-2-yl)-2-morpholinoisonicotinamide [1776]; N-(7-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)quinazolin-2-yl) cyclopropanecarboxamide [1777]; 4-fluoro-N-(7-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)quinazolin-2-yl)benzamide [1778]; N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)cyclobutanecarboxamide [1779]; 3,3-difluoro-N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)cyclobutane-1-carboxamide [1780]; N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)cyclopentanecarboxamide [1781]; 4,4-difluoro-N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [1782]; N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)tetrahydro-2H-pyran-4-carboxamide [1783]; 4-fluoro-N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)benzamide [1784]; N-(7-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl) cyclopropanecarboxamide [1785]; 4-fluoro-N-(7-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)benzamide [1786]; N-(7-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)cyclobutanecarboxamide [1787]; N-(7-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)cyclopentanecarboxamide [1788]; 4-fluoro-N-(7-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)benzamide [1789]; N-(7-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl) cyclopropanecarboxamide [1790]; 3,3-difluoro-N-(7-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl) cyclobutane-1-carboxamide [1791]; N-(7-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl) cyclopentanecarboxamide [1792]; 4-fluoro-N-(7-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)benzamide [1793]; N-(7-(6-(dimethylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1794]; N-(7-(6-(diethylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1795]; N-(7-(6-(3-aminoazetidin-1-yl)pyrazin-2-yl)quinazolin-2-yl)-4-fluorobenzamide [1796]; 2-(4-methylpiperazin-1-yl)-N-(7-(6-(pyrrolidin-1-yl)pyrazin-2-yl)quinazolin-2-yl)isonicotinamide [1797]; N-(7-(6-(azetidin-3-ylmethoxy)pyrazin-2-yl)quinazolin-2-yl)-4-fluorobenzamide [1798]; N-(7-(6-(azetidin-3-yloxy)pyrazin-2-yl)quinazolin-2-yl)-4-fluorobenzamide [1799]; N-(7-(1H-pyrrolo[2,3-b]pyridin-5-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [1800]; N-(7-(1H-pyrrolo[3,2-b]pyridin-6-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [1801]; N-(7-(1H-pyrrolo[2,3-c]pyridin-4-yl)quinazolin-2-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [1802]; N-(7-(1H-pyrrolo[2,3-b]pyridin-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1803]; N-(7-(1H-pyrrolo[3,2-b]pyridin-6-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1804]; N-(7-(1H-pyrrolo[2,3-c]pyridin-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1805]; 2-(4-methylpiperazin-1-yl)-N-(7-(oxazolo[5,4-b]pyridin-6-yl)quinazolin-2-yl)isonicotinamide [1806]; N-(7-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1807]; N-(7-(3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1808]; N-(7-(2-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1809]; N-(7-(5H-pyrrolo[2,3-b]pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1810]; N-(7-(5H-pyrrolo[2,3-b]pyrazin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1811]; 1-isopropyl-N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1812]; 1-isopropyl-N-(7-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [1813]; trans-4-((2-fluoroethyl)amino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [4566]; trans-4-((2-methoxyethyl)amino)-N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [4567]; tert-butyl (trans-4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)cyclohexyl) carbamate [4568]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-((1-methylpiperidin-4-yl)amino) isonicotinamide [4569]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide [4570]; N-(7-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide [4571]; N-(7-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [4572]; N-(7-(1-methyl-1H-1,2,3-triazol-4-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [4573]; N-(7-(1-methyl-1H-tetrazol-5-yl)quinazolin-2-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [4574]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-1-yl)propanamide [4575]; N-(7-(1,2-dimethyl-1H-imidazol-5-yl)quinazolin-2-yl)-2-(piperidin-1-yl)propanamide [4576]; 4-isopropoxy-N-(7-(7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)quinazolin-2-yl) benzamide [4577]; trans-3-morpholino-N-(7-(oxazol-5-yl)quinazolin-2-yl)cyclobutane-1-carboxamide [4578]; trans-4-(hydroxymethyl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [4579]; N-(7-(oxazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [4580]; 4-morpholino-N-(7-(oxazol-5-yl)quinazolin-2-yl)piperidine-1-carboxamide [4581]; N-(7-(oxazol-5-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [4582]; N-(7-(oxazol-5-yl)quinazolin-2-yl)-3-(piperidin-4-yloxy)benzamide [4583]; 2-methyl-N-(7-(oxazol-5-yl)quinazolin-2-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [4584]; 2-(1H-imidazol-1-yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)acetamide [4585]; trans-4-(hydroxymethyl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [4586]; trans-4-(dimethylamino)-N-(7-(thiazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [4587]; N-(7-(thiazol-5-yl)quinazolin-2-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [4588]; trans-4-(hydroxymethyl)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [4589]; trans-4-(dimethylamino)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)cyclohexane-1-carboxamide [4590]; N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [4591]; N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [4592]; 2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(7-(5-methyl-1,3,4-thiadiazol-2-yl) quinazolin-2-yl)acetamide [4593]; N-(7-(5-(cyano(4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)quinazolin-2-yl) cyclopropanecarboxamide [4594]; 4-fluoro-N-(7-(6-((1-methylazetidin-3-yl)methoxy)pyrazin-2-yl)quinazolin-2-yl)benzamide [4595]; 1-isopropyl-N-(7-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxamide [4596]; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 97.0
- Lexical Diversity: 1.45902
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15498990', '15749587', '15749923', '15749910', '15749922']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8263163283139424
- 35 USC 102 Novelty (BERT): 0.5884203705367991
- Combined Prediction Score: 0.8025267325362282
- Mean Citation Score: 444.7209820000001
- Max Citation Score: 527.2941
- Similarity Product: 429.1873566378235

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test