PATENT CLAIM ANALYSIS

Application Number: 16088695
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["514", "063000"]

Abstract:
The present invention discloses a silicon incorporated quinoline of formula (I) wherein, X, Y, A, R 1  and R 2  are as described. The present invention further discloses a process for the preparation of silicon incorporated quinolines of formula I; a pharmaceutical composition comprising silicon incorporated quinolines of formula (I) or pharmaceutically acceptable salt thereof. The present invention also discloses a method for treating diseases caused by  Plasmodium falciparum  or other  coccidian  parasites using the silicon incorporated quinolines of formula I or pharmaceutically acceptable salt thereof.

Claim (Index 2):
The compound of formula I as claimed in  claim 1 , wherein said compound of formula I is selected from the group consisting of:\n a. (4,4-dimethyl-1,4-azasilinan-1-yl)(6-fluoro-2-(4-(morpholinomethyl) phenyl) quinolin-4-yl)methanone (NDS 101006); b. N-(2-(4,4-dimethyl-1,4-azasilinan-1-yl)ethyl)-6-fluoro-2-(4-(morpholinomethyl) phenyl)quinoline-4-carboxamide (NDS 100951); c. (2-(4-((4,4-dimethyl-1,4-azasilinan-1-yl)methyl)phenyl)-6-fluoroquinolin-4-yl) (morpholino)methanone (NDS 101007); d. 2-(4-((4,4-dimethyl-1,4-azasilinan-1-yl)methyl)phenyl)-6-fluoro-N-(2-morpholinoethyl)quinoline-4-carboxamide (NDS 101008); e. 2-(4-((4,4-dimethyl-1,4-azasilinan-1-yl)methyl)phenyl)-6-fluoro-N-(2-(pyrrolidin-1-yl)ethyl) quinoline-4-carboxamide (NDS 100950); f. 2-(4-((4,4-dimethyl-1,4-azasilinan-1-yl)methyl)phenyl)-6-fluoro-N-(pyridin-2-yl) quinoline-4-carboxamide (NDS 101009); g. 6-fluoro-2-(4-(morpholinomethyl)phenyl)-N-(2-(trimethylsilyl)ethyl)quinoline-4-carboxamide (NDS 101037); h. 2-(4-((4,4-dimethyl-1,4-azasilinan-1-yl)methyl)phenyl)-6-fluoro-N-(2-(piperidin-1-yl)ethyl)quinoline-4-carboxamide (NDS 101074); i. 2-(4-((4,4-dimethyl-1,4-azasilinan-1-yl)methyl)phenyl)-6-fluoro-N-(2-(4-methylpiperazin-1-yl)ethyl)quinoline-4-carboxamide (NDS 101075); j. 2-(4-((4,4-dimethyl-1,4-azasilinan-1-yl)methyl)phenyl)-6-fluoro-N-(2-hydroxyethyl)quinoline-4-carboxamide (NDS 101076); and k. 2-(4-((4,4-dimethyl-1,4-azasilinan-1-yl)methyl)phenyl)-6-fluoro-N-(2-thiomorpholinoethyl)quinoline-4-carboxamide (NDS 101077).

Metadata:
- Claim Count in Document: 35.0
- Percentile: 97.0
- Lexical Diversity: 1.84906
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14350766', '15752896', '14895710', '11477745', '12142846']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8262984129872242
- 35 USC 102 Novelty (BERT): 0.5309380521426115
- Combined Prediction Score: 0.7967623769027629
- Mean Citation Score: 315.892494
- Max Citation Score: 361.45117
- Similarity Product: 291.7263768163723

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test