PATENT CLAIM ANALYSIS

Application Number: 15874154
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-11
Patent Classification: ["506", "003000"]

Abstract:
The present invention provides a method for the prognosis of breast cancer in a subject comprising the steps of: (a) providing a first proteome sample from the subject; (b) measuring in the first proteome sample the amount of one or more biomarkers selected from the group of biomarkers listed in Table 1; (c) providing an additional (e.g. a second) proteome sample from the subject; (d) measuring in the additional proteome sample the amount of the one or more biomarkers selected from the group of biomarkers listed in Table 1 measured in step (b); and (e) determining the difference between the amount of the one or more biomarkers in the first and additional proteome samples; wherein the first proteome sample and additional proteome sample are representative of the proteome composition of the subject on different days, and wherein the difference between the amount of the one or more biomarkers in the first and additional (e.g. second) proteome samples is indicative of the risk of recurrence and/or metastasis of the breast cancer in the subject. In further embodiments, step (b) comprises measuring the amount of each the biomarkers listed in Table 1(A) or all of the biomarkers listed in Table 1. The present invention additionally provides an array for performing the method of the invention, the use in vitro of a biomarker selected from the group of biomarkers in Table 1 as a prognostic marker for determining risk of recurrence and/or metastasis of breast cancer in a subject, and a kit for performing the method of the invention comprising one or more binding agents capable of binding to a biomarker listed in Table 1.

Claim (Index 48):
The method according to  claim 1  wherein the predicative accuracy of the method, as determined by an ROC AUC value, is at least 0.70, for example at least 0.75, 0.80 or at least 0.85.

Metadata:
- Claim Count in Document: 46.0
- Percentile: 86.0
- Lexical Diversity: 3.54023
- Patent Class: 506.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14781839', '14002494', '15038135', '11771727', '15026577']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6426013118351033
- 35 USC 102 Novelty (BERT): 0.5401161400353409
- Combined Prediction Score: 0.6323527946551271
- Mean Citation Score: 329.5022019999999
- Max Citation Score: 389.55057
- Similarity Product: 215.2974187851584

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test