PATENT CLAIM ANALYSIS

Application Number: 16431674
Application Type: Utility
Filing Date: 2019-06
Publication Date: 2019-12
Patent Classification: ["435", "007210"]

Abstract:
Provided are methods of determining the aging of skin or skin disorders or conditions by measuring and evaluating levels of skin-associated biomarker proteins in a subject's skin sample. In aspects, the levels of a subset of biomarker proteins are altered, e.g., increased or decreased, in aging/aged versus non-aging/young skin. Provided are methods for more individualized and direct treatments and therapeutic options for aging skin and/or skin disorders and conditions by determining the levels of those skin biomarker proteins that correlate with aging skin and/or certain skin attributes of a subject and administering treatment products and regimens that result in altering the levels of the biomarker proteins, in particular, toward levels of the proteins in non-aged and healthy skin.

Claim (Index 8):
A method of treating aging skin in a subject in need thereof, the method comprising:\n (a) measuring the levels of a subset of one or more biomarker proteins in a skin sample obtained from the subject, wherein said biomarker protein is selected from the group consisting of: GLUD1; DDX3X; ERGIC1; NIT2; PSMC5; TSG101; UQCRFS1; ZG16B; RAB1A; PLA2G4E; GPD2; AADAC; ATP6V1B2; PHB; NAPRT; RAB1B; SULT2B1; CARS; HSPA9; ACTR2; EIF2S1; RPL22; CAP1; ATP6V1E1; RTN3; DYNLL2; PHB2; ITPA; IST1; UQCRC2; FASN; LMNB2; MY018A; ATP6V1A; ACOX1; RPN2; RAB7A; EIF4A1; ALDH2; ACTR3; ACADVL; KRT73; ANXA5; HNRNPH2; VCP; MYH14; ANXA4; PDCD6; HSPE1; IDE; CKAP4; PIP; CAPZB; ASPRV1; MT-CO2; CAPG; RAB14; PTGS1; POF1B; HSPA5; TGM5; HSPA8; LGALS7B; HSPD1; LMNA; CALML5; HPSE; TMED9; ACPP; FUCA1; HEBP2; S100A11; RPS27A; IL1RN; CKMT1B; CTSD; TECR; KRT10; HEXB; BLMH; CAT; SYLP1; AGA; CTSH; STS; C11orf54; RNASE7; IL37; KPRP; KRT6B; KRT75; NRM; LGALS3BP; APOE; FAM175B; CDA; KRT76; KRTAP13-2; and CRYAB; (b) identifying the levels of the subset of one or more biomarker proteins in step (a) relative to levels of the same proteins in a skin sample from control subjects; wherein decreased levels of the subset of one or more biomarker proteins in the subject's sample relative to control levels identifies aging skin in the subject; and (c) administering to the subject identified as having aging skin a treatment that increases the levels of the subset of one or more biomarker proteins in the subject's skin, thereby treating aging skin in the subject.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 100.0
- Lexical Diversity: 2.13333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15013833', '14356029', '15287162', '12282840', '14569127']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.556262380752297
- 35 USC 102 Novelty (BERT): 0.4852464959677445
- Combined Prediction Score: 0.5491607922738417
- Mean Citation Score: 193.233828
- Max Citation Score: 197.38016
- Similarity Product: 137.78682508766173

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test