PATENT CLAIM ANALYSIS

Application Number: 16056478
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-11
Patent Classification: ["424", "093700"]

Abstract:
The present invention is based in part methods for treating neurodegenerative diseases and disorders. Specifically, the present invention disclose methods for treating neurodegenerative disorders suing neural stem cells (NSCs) and/or pluripotent stem cell (PSC) derived neurons or neuron precursor cells. The present invention also discloses methods to induce endogenous dopaminergic neurons to release dopamine and increase the levels of dopamine in a subject.

Claim (Index 4):
The method of  claim 3 , wherein the hpSCs are produced by a method comprising:\n a) parthenogenetically activating a human oocyte by contacting the oocyte with an ionophore at high O 2  tension and contacting the oocyte with a serine-threonine kinase inhibitor under low O 2  tension; b) cultivating the activated oocyte of (a) at low O 2  tension until blastocyst formation; c) transferring the blastocyst to a layer of feeder cells, and culturing the transferred blastocyst under high O 2  tension; d) mechanically isolating an inner cell mass (ICM) from trophectoderm of the blastocyst of (c); and e) culturing the cells of the ICM of (d) on a layer of feeder cells, wherein culturing (e) is carried out under high O 2  tension; thereby producing hpSCs.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.47917
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14181285', '14396180', '15726121', '14356042', '15016934']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6866612350346871
- 35 USC 102 Novelty (BERT): 0.6557010585972138
- Combined Prediction Score: 0.6835652173909398
- Mean Citation Score: 450.77079
- Max Citation Score: 661.95154
- Similarity Product: 588.5488969625711

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test