PATENT CLAIM ANALYSIS

Application Number: 15907480
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "006000"]

Abstract:
Provided herein are opto-genetic systems, cells, and methods thereof for modulating and regulating genetic expression in transiently active cells. The technologies described herein provide a transformative genetic regulatory tool for in vivo applications, which broadly spans a variety of disciplines, including behavioral, cognitive, and systems neuroscience.

Claim (Index 1):
A system comprising:\n a. a control module comprising a nucleic acid sequence encoding a chimeric photosensitive transcription factor operably linked to a promoter, wherein the photosensitive transcription factor comprises:\n i.a transcription activation domain; \n ii.a sequence-specific DNA binding domain; and \n iii.a photo-sensitive actuator domain which is activated by photoirradiation in a defined range of wavelengths; and \n b. a physiologically responsive module comprising a nucleic acid sequence encoding a gene of interest operably linked to an inducible promoter comprising:\n i. a sequence element that binds the sequence-specific DNA binding domain of the photosensitive transcription factor, and \n ii. a physiological response element comprising a binding site for a physiological response factor, the binding of which factor is directly regulated by a physiological agent or condition; \n wherein expression of the gene of interest in a cell comprising the system requires the presence of both the physiological agent or condition and photoirradiation within the defined range of wavelengths.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.38462
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15036020', '14105017', '12771457', '14004879', '11115922']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5983258459489763
- 35 USC 102 Novelty (BERT): 0.491652559800779
- Combined Prediction Score: 0.5876585173341566
- Mean Citation Score: 255.01408
- Max Citation Score: 261.08667
- Similarity Product: 208.5565122261984

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test