PATENT CLAIM ANALYSIS

Application Number: 15762852
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "252030"]

Abstract:
Described are compounds, which are antagonists of the P2Y 14  receptor, for example, a compound of formula (I) in which ring A, R 1 , R 2 , R 3 , and n are as described herein. Also provided are dendron conjugates comprising the compounds, and methods of using the compounds, including a method of treating a disorder, such as inflammation, diabetes, insulin resistance, hyperglycemia, a lipid disorder, obesity, a condition associated with metabolic syndrome, and asthma, and a method of antagonizing P2 14  receptor activity in a cell.

Claim (Index 14):
The compound of  claim 1 , wherein the compound is a conjugate of formula (III) or a pharmaceutically acceptable salt thereof, wherein\n ring A is aryl, heteroaryl, or cycloalkyl; \n R 1  is \u2014CO 2 H, \u2014CO 2 (C 1 -C 8  alkyl), or a bioisostere of carboxylate; \n each R 3  is the same or different and each is C 1 -C 8  alkyl, C 2 -C 8  alkenyl, C 3 -C 6  cycloalkyl, hydroxy, hydroxyalkyl, C 1 -C 8  alkoxy, C 3 -C 6  cycloalkyloxy, aryloxy, halo, C 1 -C 8  haloalkyl, C 1 -C 8  haloalkoxy, \u2014CN, \u2014NO 2 , \u2014NR 5 R 6 , \u2014C(O)R 4 , \u2014CO 2 R 4 , \u2014C(O)NR 5 R 6 , \u2014NR 5 C(O)R 4 , \u2014(CH 2 ) m aryl, \u2014(CH 2 ) m heteroaryl, or \u2014(CH 2 ) m heterocycloalkyl; \n R 4 , R 5 , and R 6  are the same or different and each is H or C 1 -C 8  alkyl; \n X 1  is selected from the group consisting of \u2014(CH 2 ) o \u2014, \u2014C(O)\u2014, \u2014C(O)NH\u2014, \u2014OC(O)NH\u2014, \u2014OC(O)\u2014, \u2014C(O)O\u2014, \u2014C(S)NH\u2014, and \u2014SO 2 \u2014; \n X 2  is selected from the group consisting of \n R 7  is CH 2 , NH, or O; X 3  is a dendron; X 4  is selected from the group consisting of \u2014(CH 2 ) o \u2014, \u2014C(O)\u2014, \u2014C(O)NH\u2014, \u2014OC(O)NH\u2014, \u2014OC(O)\u2014, \u2014C(O)O\u2014, \u2014C(S)NH\u2014, \u2014SO 2 \u2014, \u2014NHC(O)\u2014, and X 5  is a reactive sulfur-containing moiety; m, n, and q are the same or different and each is 0 or an integer from 1-5; o is an integer from 1-5; and p is 0 or an integer from 1-36; wherein X 5  is optionally linked to a particle.

Metadata:
- Claim Count in Document: 51.0
- Percentile: 90.0
- Lexical Diversity: 1.77049
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14352096', '15554829', '10015532', '15124654', '14305643']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7836293545698034
- 35 USC 102 Novelty (BERT): 0.5109609458405473
- Combined Prediction Score: 0.7563625136968778
- Mean Citation Score: 264.953122
- Max Citation Score: 268.13614
- Similarity Product: 194.06498442293045

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test