PATENT CLAIM ANALYSIS

Application Number: 16034610
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["530", "300000"]

Abstract:
The invention relates to a method for determining the presence of at least one distinct polypeptide in a biological sample comprising contacting the biological sample with a hydrolyzing agent, wherein the hydrolyzing agent is capable of hydrolyzing the distinct polypeptide in a sequence-specific manner such that at least one distinct peptide having a predetermined peptide measured accurate mass would result if the at least one distinct polypeptide were present in the biological sample, to obtain a hydrolyzed sample; bringing the hydrolyzed sample in contact with a substrate comprising at least one immobilized binding partner, wherein the at least one immobilized binding partner is capable of specifically binding the distinct peptide; removing the hydrolyzed sample from the substrate in a manner such that the distinct peptide would remain bound to the immobilized binding partner; contacting the substrate with an elution solution, wherein the distinct peptide would dissociate from the immobilized binding partner into the elution solution; subjecting a portion of the elution solution to liquid chromatography to segregate a plurality of molecules in the portion of the elution solution to obtain sorted molecules; determining the measured accurate mass of at least one sorted molecule present in the elution solution; and determining the presence of the at least one distinct polypeptide in the biological sample when a measured accurate mass of at least one molecule is substantially equal to the predetermined peptide measured accurate mass.

Claim (Index 40):
The method of  claim 29 , wherein the biological sample comprises a number of different polypeptides selected from the group consisting of between about 5,000 to about 20,000 different polypeptides, between about 7,500 to about 15,000 different polypeptides, and up to about 100,000 different polypeptides and isoforms thereof.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 95.0
- Lexical Diversity: 3.21053
- Patent Class: 530.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12931445', '15245393', '13856933', '13683778', '13575834']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7313982115139238
- 35 USC 102 Novelty (BERT): 0.5577878459941817
- Combined Prediction Score: 0.7140371749619496
- Mean Citation Score: 331.30275199999994
- Max Citation Score: 491.19046
- Similarity Product: 313.5013416672647

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test