PATENT CLAIM ANALYSIS

Application Number: 16047499
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["424", "093200"]

Abstract:
The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer. Oncolytic viral vectors incorporate one or more of the following features: viral replication restriction by insertion of tumor-suppressive microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle.

Claim (Index 1):
A recombinant herpes simplex virus (HSV) comprising:\n a deletion in the internal join region such that the recombinant HSV genome comprises one copy of each of the ICP0, \u03b334.5, LAT, and ICP4 genes; and at least one copy of a micro-RNA (miR)-124 target sequence inserted into the ICP4 locus of the recombinant HSV genome and at least one copy of a miR-122 target sequence inserted into the ICP27 locus of the recombinant HSV genome, wherein replication of the recombinant HSV is reduced in a first cell compared to replication of the recombinant HSV in a second cell and wherein the endogenous expression of miR-124 or miR-122 in the second cell is reduced compared to the endogenous expression of miR-124 or miR-122 in the first cell.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 95.0
- Lexical Diversity: 1.42857
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13735760', '11855792', '15606747', '14112684', '11273640']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6624529062565668
- 35 USC 102 Novelty (BERT): 0.5403804483633937
- Combined Prediction Score: 0.6502456604672495
- Mean Citation Score: 385.257516
- Max Citation Score: 388.0018
- Similarity Product: 242.5594968146801

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test