PATENT CLAIM ANALYSIS

Application Number: 15743424
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["546", "276700"]

Abstract:
The invention provides compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D 1 , D 2 , D 3 , X, Y, A 1 , A 2 , R 1 , R 5  and the subscript a are as described herein. The compounds are CETP inhibitors and are useful for raising FIDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:

Claim (Index 3):
The compound of  claim 2 , or a pharmaceutically acceptable salt thereof:\n wherein X is \u2014C(\u2550O)\u2014 or \u2014S(O) 2 \u2014; R 9  is H or \u2014C 1 -C 3 alkyl optionally substituted with 1-7 halogens; R 1  is CH 3 , CF 3 , \u2014OCH 3 , \u2014OCF 3 , halogen, or \u2014NR 6 R 7 ; R 6  and R 7  are each independently H or \u2014C 1 -C 5  alkyl; R 2 , R 3 , and R 4  are each independently H, C 1 -C 3 alkyl, CF 3 , \u2014OC 1 -C 3 alkyl, \u2014OCF 3 , or halogen; each R 5  is independently CH 3 , CF 3 , \u2014OCH 3 , \u2014OCF 3 , or halogen; A 1  is phenyl, HET(1), or C 3 -C 6  cycloalkyl optionally having 1-2 double bonds, wherein A 1  is optionally substituted with one substituent group Z and is optionally substituted with 1-3 groups which are each independently \u2014C 1 -C 3 alkyl optionally substituted with 1-5 halogens, \u2014OC 1 -C 3 alkyl optionally substituted with 1-5 halogens, halogen, \u2014OH, or \u2014CN; each HET(1) is a 5- or 6-membered heterocyclic ring having 1-3 heteroatom groups which are each independently \u2014N\u2014, \u2014NH\u2014, \u2014S\u2014, or \u2014O\u2014, optionally having one group \u2014C(\u2550O)\u2014, and optionally having 1-3 double bonds; Z is A 3 , \u2014(CH 2 ) 1-3 \u2014CO 2 R 8 , \u2014(CH 2 ) 1-3 \u2014C(O)NR 6 R 7 , \u2014(CH 2 ) 1-3 \u2014SO 2 NR 6 R 7 , \u2014CO 2 R 8 , \u2014C(O)NR 6 R 7 , \u2014SO 2 NR 6 R 7 , or \u2014(CH 2 ) 1-3 -HET(2); R 8  is H or \u2014C 1 -C 3  alkyl optionally substituted with 1-3 halogens; A 3  is phenyl, C 3 -C 6  cycloalkyl optionally having 1-2 double bonds, or HET(1),\n wherein A 3  is optionally substituted with 1-3 groups which are each independently CH 3 , CF 3 , \u2014OCH 3 , \u2014OCF 3 , \u2014OH, or halogen, and \n A 3  is optionally substituted with one group which is HET(2), \u2014(CH 2 ) 1-2 \u2014CO 2 R 8 , \u2014(CH 2 ) 1-2 \u2014C(O)NR 6 R 7 , \u2014(CH 2 ) 1-2 \u2014SO 2 NR 6 R 7 , \u2014CO 2 R 8 , \u2014C(O)NR 6 R 7 , \u2014SO 2 NR 6 R 7 , or \u2014C(O)NR 6 cyclopropyl,\n wherein said cyclopropyl of \u2014C(O)NR 6 cyclopropyl is optionally substituted with 1-3 substituents which are independently selected from 1-3 halogens, one CH 3 , and one \u2014CN, and \n wherein HET(2) is optionally substituted with 1-3 groups which are each independently CH 3 , CF 3 , \u2014OCH 3 , \u2014OCF 3 , halogen, or NR 6 R 7 ; \n \n A 2  is phenyl or HET(1), wherein A 2  is substituted with 1-3 substituent groups which are each independently CH 3 , CF 3 , \u2014OCH 3 , \u2014OCF 3 , halogen, \u2014CN, \u2014OH, or C 3 -C 4 cycloalkyl optionally substituted with 1-3 substituents which are each independently halogen, CF 3 , CH 3 , \u2014OCF 3 , or \u2014OCH 3 ; and a is 0, 1, or 2.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 86.0
- Lexical Diversity: 1.63043
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14908180', '13660010', '15329284', '15104351', '15028306']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8424386322829782
- 35 USC 102 Novelty (BERT): 0.5666238701986678
- Combined Prediction Score: 0.8148571560745472
- Mean Citation Score: 434.067694
- Max Citation Score: 454.36414
- Similarity Product: 417.4339133351731

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test