PATENT CLAIM ANALYSIS

Application Number: 16038734
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "332000"]

Abstract:
The invention relates to oligopyridylamide alpha-helix mimetic compounds and their use to inhibit p53 aggregation and restore its tumor suppressor function for treating diseases, e.g., cancers, associated with p53 mutations, e.g., R248W p53 mutation.

Claim (Index 19):
The method of  claim 13 , wherein the compound has the structure according to formula (II): wherein R 1 \u2032 is selected from a straight chained, branched or cyclic aliphatic C 1 -C 20  hydrocarbon; an aromatic C 6 -C 20  hydrocarbon; a heteroaromatic C 1 -C 20  hydrocarbon; an aryl C 6 -C 20  hydrocarbon; a heteroaryl C 1 -C 20  hydrocarbon, a C 1 -C 12  perfluorocarbon, or a combination thereof, each of which optionally contains 1-8 heteroatoms selected from halogen, O, N, and S, and each of which is optionally substituted with one or more of \u2014NH 2 ; \u2014NHR*; \u2014N(R*) 2 ; \u2014N(R*) 3 + ; \u2014(C\u2550O)\u2014R*; \u2014CHO; \u2014CO 2 H; \u2014CO 2 R*; \u2014(C\u2550O)\u2014S\u2014R*; \u2014O\u2014(C\u2550O)\u2014H; \u2014O\u2014(C\u2550O)\u2014R*; and combinations thereof; R 2 \u2032 is selected from a straight chained, branched or cyclic aliphatic C 1 -C 20  hydrocarbon; an aromatic C 6 -C 20  hydrocarbon; a heteroaromatic C 1 -C 20  hydrocarbon; an aryl C 6 -C 20  hydrocarbon; a heteroaryl C 1 -C 20  hydrocarbon, a C 1 -C 12  perfluorocarbon, or a combination thereof, each of which optionally contains 1-8 heteroatoms selected from halogen, O, N, and S, and each of which is optionally substituted with one or more of \u2014NH 2 ; \u2014NHR*; \u2014N(R*) 2 ; \u2014N(R*) 3 + ; \u2014(C\u2550O)\u2014R*; \u2014CHO; \u2014CO 2 H; \u2014CO 2 R*; \u2014(C\u2550O)\u2014S\u2014R*; \u2014O\u2014(C\u2550O)\u2014H; \u2014O\u2014(C\u2550O)\u2014R*; and combinations thereof; R 3 \u2032 is selected from a straight chained, branched or cyclic aliphatic C 1 -C 20  hydrocarbon; an aromatic C 6 -C 20  hydrocarbon; a heteroaromatic C 1 -C 20  hydrocarbon; an aryl C 6 -C 20  hydrocarbon; a heteroaryl C 1 -C 20  hydrocarbon, a C 1 -C 12  perfluorocarbon, or a combination thereof, each of which optionally contains 1-8 heteroatoms selected from halogen, O, N, and S, and each of which is optionally substituted with one or more of \u2014NH 2 ; \u2014NHR*; \u2014N(R*) 2 ; \u2014N(R*) 3 + ; \u2014(C\u2550O)\u2014R*; \u2014CHO; \u2014CO 2 H; \u2014CO 2 R*; \u2014(C\u2550O)\u2014S\u2014R*; \u2014O\u2014(C\u2550O)\u2014H; \u2014O\u2014(C\u2550O)\u2014R*; and combinations thereof; A\u2032 is selected from \u2014NO 2 ; \u2014NH 2 ; \u2014NHR*; \u2014N(R*)\u2014(C\u2550O)\u2014R*, \u2014N(R*) 2 , where R* is hydrogen or an aliphatic C 1 -C 12  hydrocarbon; and B\u2032 is selected from \u2014(C\u2550O)\u2014R*; \u2014CO 2 H; \u2014CO 2 R*, where R* is hydrogen or an aliphatic C 1 -C 12  hydrocarbon; R* is independently selected at each occurrence from hydrogen or C 1 -C 12  hydrocarbons each of which optionally contains 1-8 heteroatoms selected from halogen, O, N, and S and combinations thereof; with the proviso that (i) when R 1  and R 3  are both \u2014CH 2 CO 2 H, R 2  is not \u2014CH 2 CO 2 H or a straight chained, branched or cyclic aliphatic C 1 -C 12  hydrocarbon, or R 2  does not have the structure \u2014C[CH 2 CO 2 H] 3 ; and (ii) R 1  through R 3  are not each an unsubstituted C 1 -C 8  hydrocarbon, or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 95.0
- Lexical Diversity: 1.29032
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14521972', '14409607', '13721491', '12344868', '14412185']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.761254210772229
- 35 USC 102 Novelty (BERT): 0.5213549347029851
- Combined Prediction Score: 0.7372642831653047
- Mean Citation Score: 278.346004
- Max Citation Score: 285.72833
- Similarity Product: 195.82232735233072

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test