PATENT CLAIM ANALYSIS

Application Number: 15566418
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "210000"]

Abstract:
Compounds of formula I are provided. Also provided are methods of preparing the compounds of formula (I), and methods of using the compounds of formula (I) as a negative allosteric modulator of a metabotropic glutamate receptor (mGluR) subtype 5.

Claim (Index 1):
A 5-aromatic alkynyl-substituted benzamide compound having a structure represented by the following general formula I, and racemate, R-isomer, S-isomer, pharmaceutically acceptable salt, or mixture thereof: X is CH or N; R 1  is selected from the following group: hydrogen, halogen, C1-C6 alkyl, halogen substituted C1-C6 alkyl, cyano; R 2  and R 3  are each independently select from the group consisting of hydrogen, substituted or unsubstituted phenyl, substituted or unsubstituted 3-7 membered heteroaryl, substituted or unsubstituted 5-7 membered aryl-methylene, 3-7 membered heterocyclyl-methylene, while each heterocyclyl independently contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen; and R 2  and R 3  are not simultaneously hydrogen; or R 2  and R 3  together with the attached N atom form a group selected from the group consisting of substituted or unsubstituted 5-20 membered hetero spirocyclic ring, or substituted or unsubstituted 4-20 membered fused heterocyclic ring; wherein the substituted means one or more hydrogen atoms of the group are substituted by substituents selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, halogen-substituted C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, cyano, nitro, amino, hydroxy, hydroxymethyl, carboxy, mercapto, sulfonyl, C6-C10 aryl, and 3-12 membered heterocyclyl; wherein the hetero spirocyclic ring, fused heterocyclic ring or heterocyclyl each independently contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen; \u2003ring is selected from the group consisting of substituted or unsubstituted 5-6 membered aromatic heterocycle, substituted or unsubstituted 6-20 membered hetero aromatic fused ring, wherein the substituent is 1, 2, 3 or 4 substituents selected from the group consisting of halogen, C1-C6 alkyl, halogen-substituted C1-C6 alkyl, C1-C6 alkoxy, halogen-substituted C1-C6 alkoxy, C3-C8 cycloalkyl, C3-C8 halogenated cycloalkyl, cyano, nitro, amino(\u2014NH 2 ), amino (preferably C1-C6 amino), hydroxy, hydroxymethyl, carboxy, mercapto, sulfonyl, C6-C10 aryl and 3-12 membered heterocyclyl, wherein the aromatic heterocycle, hetero aromatic fused ring or the heterocyclyl each independently contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen; and when R 1  is H, \u2003ring is substituted or unsubstituted 5 membered aromatic heterocyclic ring; the halogen is F, Cl, Br or I.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 88.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14344957', '12908588', '15771920', '12912124', '13542234']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8373467045614165
- 35 USC 102 Novelty (BERT): 0.5282122191173557
- Combined Prediction Score: 0.8064332560170104
- Mean Citation Score: 333.88199999999995
- Max Citation Score: 349.1565
- Similarity Product: 268.9540139910579

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test