PATENT CLAIM ANALYSIS

Application Number: 16175895
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "318000"]

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

Claim (Index 2):
The compound according to  claim 1  having the structure of Formula (IIa) or the structure of Formula (IIb), or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof; wherein X 1  is C or N; X 2  and X 3  are each independently CH, N, O, or S; E 1  and E 3  are each independently a covalent bond, O, S, N, NH, CH, or CH 2 ; E 2  is O, S, N, NH, CH, or CH 2 ; wherein (E 1  and E 2 ) or (E 3  and E 2 ) forms a single bond or double bond; provided that (1) the bonds between (E 1  and E 2 ) and (E 3  and E 2 ) are not both double bonds; and (2) at least one of E 1 , E 2 , and E 3  is not O, S, N, or NH; Y is O, S, NH, or CH 2 ; m, n, and p are each independently 0 or 1; L 1  is a covalent bond, C 1-3  alkylene, C 1-3  heteroalkylene, C 2-4  alkenylene, C 2-4  alkynylene, or a 5- to 6-membered heteroaryl containing 1 to 3 heteroatoms independently selected from N, O, and S; wherein the alkylene, heteroalkylene, and heteroaryl are independently substituted with 0 to 3 R 9 ; Z is phenyl, or 5- to 10-membered heteroaryl, wherein the phenyl and heteroaryl are independently substituted with 0 to 3 R 10 ; R X  is \u2014(CH 2 ) e \u2014C(O)OH; R 1  is C 1-6  alkyl or C3-s cycloalkyl, wherein the alkyl or cycloalkyl is substituted with 0 to 3 R 15 ; and R 2  is phenyl or 6-membered heteroaryl, wherein the phenyl or heteroaryl is substituted with 0 to 3 R 16 .

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14971875', '15541018', '14971825', '16322945', '12377307']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8047980476664548
- 35 USC 102 Novelty (BERT): 0.5327688745351166
- Combined Prediction Score: 0.777595130353321
- Mean Citation Score: 329.48176399999994
- Max Citation Score: 338.1815
- Similarity Product: 274.4295949791074

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test