PATENT CLAIM ANALYSIS

Application Number: 16068559
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["544", "331000"]

Abstract:
The present invention provides compounds of Formula (I) or a subgeneric structure or species thereof or a pharmaceutically acceptable salt, ester, solvate, and/or prodrug thereof and methods and compositions for treating or ameliorating abnormal cell proliferative disorders, such as cancer, wherein A, R 2 , R 3 , R 10 , E 1 , E 2 , E 3 , Y, and Z are as defined herein.

Claim (Index 69):
The compound of  claim 2 , wherein the compound has the structure of formula (XIIIB): or a stereoisomer or a pharmaceutically acceptable salt, solvate, ester, tautomer, or prodrug thereof; wherein:\n each of X 2 , X 6 , X 7 , and X 8  is independently CR 4  or N; wherein not more than two of X 2 , X 6 , X 7 , and X 8  are N; \n Z is CH or N; \n R 1  is independently selected from hydrogen, fluoro, chloro, bromo, methyl, ethyl, hydroxyl, methoxy, ethoxy, isopropxy, cyclopropoxy, \u2014OCF 3 , \u2014OCH 2 CF 3 , \u2014OCH 2 CHF 2 , ethenyl, ethynyl, CF 3 , CHF 2 , CHO, CH 2 OH, CONH 2 , CO 2 Me, CONHMe, CONMe 2 , and cyano; \n R 2  is \u2014OCF 3 , \u2014OCHF 2 , \u2014OCF 2 CF 3 , \u2014OCH 2 CHF 2 , \u2014OCH 2 CF 3 , cyclopropyl, cyclopropoxy, methoxy, \u2014OCD 3 , ethoxy, or isopropoxy; \n R 3  is N(R 10 )C 2-6  alkyl-NR 10 R 10 , N(R 10 )C 2-6  alkyl-R 7 , O(CH 2 )R 7 , N(R 10 )C(\u2550O)(CH 2 ) p R 7  or R 7 ; \n each R 4  is independently H, cyano, nitro, halo, \u2014C 1-6  alkyl, \u2014C 1-6  haloalkyl, carboxy-C 1-6  alkyl, \u2014C 1-6  hydroxyalkyl, R 8 R 9 N\u2014C 1-6  alkyl-, \u2014C 2-6  alkenyl, \u2014C 1-6  alkynyl, C 1-6  acyl-, R 7 \u2014(CH 2 ) p C(\u2550O)\u2014, C 1-6  hydroxyalkyl-C(\u2550O)\u2014, carboxy, \u2014C 1-6  alkoxycarbonyl, \u2014C(\u2550O)NR 8 R 9 , hydroxyl, alkoxy, \u2014OCD 3 , C 1-6  acyloxy, \u2014NR 8 R 9 , C 1-6  acyl-N(R 10 )\u2014, R 7 SO 2 \u2014; \n R 4N  is H, \u2014CD 3 , \u2014C 1-6  alkyl, or \u2014C 1-6  haloalkyl; \n wherein when X 6  is C\u2014OH, X 7  is N, and X 8  is CR 4 , then the bicyclic ring containing X 2  can be tautomerized between \n R 7  is OH, NR 8 R 9 , O(CH 2 ) q NR 8 R 9 , C 1-6  alkoxy, or C 2-6  hydroxyalkoxy; R 8  and R 9  are independently H, \u2014CD 3 , C 1-6  alkyl, C 3-6  alkenyl, C 3-6  alkynyl, C 34  cycloalkyl, C 3-6  cycloalkenyl, C 1 -C 6  acyl, 4-12 membered monocyclic or bicyclic heterocyclyl, 4-12 membered monocyclic or bicyclic heterocyclyl-C 1 -C 6  alkyl-, C 6 -C 12  aryl, 5-12 membered heteroaryl; and R 8  and R 9  may be further independently substituted with up to three substituents chosen from hydroxyl, C 1-6  alkoxy, C 1-6  hydroxyalkylC 2-6  hydroxyalkoxy, oxo, thiono, cyano or halo; or alternatively, R 8  and R 9 , taken together with the N atom to which they are both attached, form a heterocyclic ring of 4-7 members, containing up to one other heteroatom chosen from O, S, or NR 11 , or a heterobicyclic ring of 7-12 members which may be fused, bridged or spiro, and contain up to two other heteroatoms chosen from O, S(O) x , or NR 11 , and these heterocyclic rings are optionally substituted with up to three substituents chosen from hydroxyl, C 1-6  alkoxy, C 1-6  hydroxyalkyl, C 1-6  alkoxy-C 1-6  alkyl, C 1-6  alkoxy-C 1-6  alkoxy, C 2-6  hydroxyalkoxy, oxo, thiono, cyano or halo; each R 10  is independently H, \u2014CD 3 , C 1-6  alkyl, C 3-6  cycloalkyl, C 2-6  hydroxyalkyl, C 1-6  alkoxy-C 1-6  alkyl or C 2-6  alkyl-NR 8 R 9 ; or alternatively, two R 10  on the same N atom to which they are both attached, form a heterocyclic ring of 5-6 members, containing up to one other heteroatom selected from O, S, or NR 11 ; each R 11  is independently hydrogen or C 1 -C 6 alkyl, which is optionally substituted with up to three substituents selected from hydroxyl, oxo, thiono, cyano and halo; p=0, 1, 2, 3, or 4, q=2, 3, or 4; and x=0, 1, or 2.

Metadata:
- Claim Count in Document: 70.0
- Percentile: 95.0
- Lexical Diversity: 1.5098
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13229178', '12008840', '12842389', '11282119', '12310150']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8094552379165328
- 35 USC 102 Novelty (BERT): 0.5197069867427281
- Combined Prediction Score: 0.7804804127991524
- Mean Citation Score: 314.529296
- Max Citation Score: 321.7707200000001
- Similarity Product: 219.38930162754065

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test