PATENT CLAIM ANALYSIS

Application Number: 15769904
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["435", "006110"]

Abstract:
The present invention provides a plurality of pairs of proximity probes, each pair being capable of binding to a different target analyte, wherein the first and second proximity probes of each pair of probes comprise universal oligonucleotides conjugated to their analyte binding moieties, and hybridised to the universal oligonucleotides are different tag oligonucleotides comprising universal complement domains common to all tag oligonucleotides and unique domains unique to each tag oligonucleotide, as well as methods for their production.

Claim (Index 21):
A plurality of pairs of proximity probes, each pair comprising a first and a second proximity probe and each pair being capable of binding to a different target analyte, wherein each proximity probe comprises an analyte-binding domain and a partially double-stranded nucleic acid domain and each proximity probe of a pair can simultaneously bind to a target analyte, and wherein the nucleic acid domains of a pair of proximity probes are able to interact directly or indirectly upon binding of the pair of proximity probes to their target analyte, wherein:\n a. each of the plurality of first proximity probes comprise a first universal oligonucleotide conjugated to a first analyte binding moiety and one of a plurality of different first tag oligonucleotides hybridised to the first universal oligonucleotide, wherein each different first tag oligonucleotide comprises a first universal complement domain which is common to all first tag oligonucleotides and which is complementary to the first universal oligonucleotide, and a first unique domain which is unique to each different first tag oligonucleotide and which is not capable of hybridising to a first or second universal oligonucleotide; and b. each of the plurality of second proximity probes comprise a second universal oligonucleotide conjugated to a second analyte binding moiety and one of a plurality of different second cognate tag oligonucleotides hybridised to the second universal oligonucleotide, wherein each different second tag oligonucleotide comprises a second universal complement domain which is common to all second tag oligonucleotides and which is complementary to the second universal oligonucleotide, and a second unique domain which is unique to each different second tag oligonucleotide and which is not capable of hybridising to a first or second universal oligonucleotide; wherein said first and second unique domains of each pair of proximity probes are cognate domains capable of mediating an interaction, directly or indirectly, with each other, thereby enabling the nucleic acid domains of the first and second proximity probes to interact when said proximity probes have bound to their target analyte.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 91.0
- Lexical Diversity: 1.74468
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14116706', '15374135', '14442701', '12294031', '09785657']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5874809654380504
- 35 USC 102 Novelty (BERT): 0.5131837906721864
- Combined Prediction Score: 0.5800512479614641
- Mean Citation Score: 285.23016799999994
- Max Citation Score: 306.63593
- Similarity Product: 252.6630718424964

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test