PATENT CLAIM ANALYSIS

Application Number: 16313956
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["546", "197000"]

Abstract:
Compounds of formula I, wherein R a  and R b  are as defined in the claims, exhibit alpha2C antagonistic activity and are thus useful as alpha2C antagonists.

Claim (Index 10):
The compound according to  claim 1 , wherein the compound is 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4,4-dimethylpyrrolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4,4-diphenyl-imidazolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-phenylimidazolidin-2-one, (3R,4R)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3,4-dimethylpyrrolidine-2,5-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5,5-diethyloxazolidine-2,4-dione, (R)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-isopropyl-4-phenylimidazolidin-2-one, (S)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-isopropyl-4-phenylimidazolidin-2-one, (R)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-phenylimidazolidin-2-one, (S)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-phenyl-imidazolidin-2-one, 6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)piperidin-3-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one, 6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one, 5-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazol-4-one, (R)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-methyl-3-phenylpyrrolidin-2-one, (S)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-methyl-3-phenylpyrrolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-ethylimidazolidin-2-one, 2-(3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)-piperidin-3-yl)-2-oxoimidazolidin-1-yl)-N,N-dimethylacetamide, 5-tert-butyl-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)oxazolidin-2-one, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-isopropyloxazolidin-2-one, N-((3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-2-oxooxazolidin-5-yl)methyl)acetamide, 3-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-(4-fluorophenyl)oxazolidin-2-one, 6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one, 6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one, 5-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1-methyl-4,5-dihydropyrrolo-[3,4-c]pyrazol-6(1H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)indolin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4,6-difluoro-2-methyl-1H-benzo[d]imidazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5,6-difluoro-2-methyl-1H-benzo[d]imidazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)piperidin-3-yl)pyrrolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)piperidin-3-yl)-5-methylpyrrolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-phenylpyrrolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-phenylpyrrolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)pyrrolidine-2,5-dione, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione, 1-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-methyl-3-phenylpyrrolidine-2,5-dione, (R)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-methyl-3-phenylpyrrolidine-2,5-dione, (S)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-methyl-3-phenylpyrrolidine-2,5-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1-phenyl-3-azabicyclo[3.1.0]-hexane-2,4-dione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-phenylpyrrolidine-2,3-dione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-phenyl-1H-pyrrol-2(5H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-methyl-1H-pyrrol-2(5H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-(4-fluorophenyl)-1H-pyrrol-2(5H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-methyl-3-phenyl-1H-pyrrol-2(5H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-(2-methoxyphenyl)-1H-pyrrol-2(5H)-one formate, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4,4-dimethylimidazolidin-2-one, (R)-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-4-methylimidazolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-methylimidazolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-phenylimidazolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3,4-dimethylimidazolidin-2-one, 1-benzyl-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3,4,4-trimethylimidazolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-(1-phenylethyl)imidazolidin-2-one hydrochloride, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)tetrahydropyrimidin-2(1H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-methyl-tetrahydropyrimidin-2(1H)-one, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-methoxyisoindolin-1-one, 2-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4,5-difluoroisoindolin-1-one hydrochloride, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-fluoroisoindolin-1-one hydrochloride, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-fluoroisoindolin-1-one hydrochloride, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)piperidin-3-yl)-5-methylisoindolin-1-one formate, 5-chloro-2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)isoindolin-1-one, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)isoindoline-1,3-dione, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-fluoroisoindoline-1,3-dione, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-4-fluoroisoindoline-1,3-dione hydrochloride, 4-chloro-2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)isoindoline-1,3-dione hydrochloride, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-methoxy-isoindoline-1,3-dione, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4,5-dimethoxyisoindoline-1,3-dione hydrochloride, 2-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1-oxoisoindoline-5-carbonitrile, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5,6-dimethoxyisoindolin-1-one, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-methoxyisoindolin-1-one, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-6-methoxyisoindolin-1-one, N-((2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)piperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)acetamide, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)quinazoline-2,4(1H,3H)-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-5-ethyl-1-methyl-5-phenylimidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-methyl-5-phenylimidazolidine-2,4-dione, 6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one, 6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one, 6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one, 5-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4H-pyrrolo-[3,4-d]thiazol-6(5H)-one, 5-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-1-methyl-5,6-dihydropyrrolo[3,4-c]pyrazol-4(1H)-one, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-6-fluoro-1H-benzo[d]imidazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-6-fluoro-2-methyl-1H-benzo[d]imidazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-2-ethyl-6-fluoro-1H-benzo[d]-imidazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-6-fluoro-2-isopropyl-1H-benzo[d]imidazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-6-fluoro-1H-benzo[d]imidazol-2(3H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-fluoro-1H-benzo[d]imidazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-fluoro-1H-benzo[d]imidazol-2(3H)-one, 6-chloro-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1H-benzo[d]imidazole, 6-chloro-1-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-2-methyl-1H-benzo[d]imidazole, 5-chloro-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1H-benzo[d]-imidazole, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione hydrochloride, (3aR,7aS)-2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione hydrochloride, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-azabicyclo[3.1.0]hexane-2,4-dione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-ethylpyrimidine-2,4,6(1H,3H,5H)-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-methylpyrrolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-methylpyrrolidin-2-one diastereomer 1,1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-methylpyrrolidin-2-one diastereomer 2,1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3,3-dimethylpyrrolidin-2-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-methylimidazolidin-2-one, 3-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1-methylimidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1-isopropylimidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-1-ethylimidazolidine-2,4-dione, 1-cyclopentyl-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1-isobutylimidazolidine-2,4-dione, 1-(cyclopropylmethyl)-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4-dione, 2-(3-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-2,4-dioxoimidazolidin-1-yl)-N,N-dimethyl-acetamide, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5,5-dimethylimidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1,5,5-trimethylimidazolidine-2,4-dione, (R)-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-methylimidazolidine-2,4-dione, (S)-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-methylimidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-5-phenylimidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)-piperidin-3-yl)-1,5-dimethylimidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-1-isopropyl-5,5-dimethyl-imidazolidine-2,4-dione, 1-tert-butyl-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4-dione, 1-benzyl-3-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4-dione, 1-cyclopropyl-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4-dione, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-1-(oxetan-3-yl)imidazolidine-2,4-dione, 1-(3,3-difluorocyclobutyl)-3-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4-dione, 6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-4,6-diazaspiro[2.4]heptane-5,7-dione, 6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-4-methyl-4,6-diazaspiro[2.4]heptane-5,7-dione, 2-(6-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5,7-dioxo-4,6-diazaspiro[2.4]heptan-4-yl)-N,N-dimethyl-acetamide, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-ethylimidazolidine-2,4,5-trione, 1-cyclohexyl-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4,5-trione, 1-cyclopentyl-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-((R)-1-phenylethyl)imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-phenylimidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-isopropylimidazolidine-2,4,5-trione, 1-benzyl-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-propylimidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)-piperidin-3-yl)-3-((S)-1-phenylethyl)imidazolidine-2,4,5-trione, 1-tert-butyl-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-(2-(dimethylamino)ethyl)imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-(piperidin-4-yl)imidazolidine-2,4,5-trione dihydrochloride, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-methylimidazolidine-2,4,5-trione, 1-(1-acetylpiperidin-4-yl)-3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-methyl)piperidin-3-yl)imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)piperidin-3-yl)-3-(pyridin-4-ylmethyl)imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-isobutylimidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-(pyridin-2-ylmethyl)imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-(pyridin-3-ylmethyl)-imidazolidine-2,4,5-trione, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1H-benzo[d]imidazol-2(3H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1H-benzo[d][1,2,3]triazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1,3-dihydrobenzo[c][1,2,5]-thiadiazole-2,2-dioxide, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1H-benzo[d]imidazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-3-phenyl-1H-benzo[d]imidazol-2(3H)-one, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-2-methyl-1H-benzo[d]imidazole, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-2-(methoxymethyl)-1H-benzo[d]imidazole, 1-(6-chloro-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-N,N-dimethylmethanamine, 1-(6-chloro-1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-N-methylmethanamine, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-4-fluoro-1H-benzo[d]imidazol-2(3H)-one, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5-methoxy-2-methyl-3H-imidazo[4,5-b]pyridine, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]-dioxin-2-yl)methyl)-piperidin-3-yl)-2-methyl-3H-imidazo[4,5-b]pyridine, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-2-methyl-1H-imidazo[4,5-b]-pyridine, 1-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-2-methyl-1H-imidazo[4,5-c]pyridine, 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-methyl)piperidin-3-yl)-2-ethyl-3H-imidazo[4,5-b]pyridine, 9-((S)-1-(((S)-2,3-dihydrobenzo-[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-8-methyl-9H-purine, 9-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-piperidin-3-yl)-9H-purine, 2-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)-5,5-dimethylisothiazolidine-1,1-dioxide, or 3-((S)-1-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidin-3-yl)oxazolidine-2,4-dione.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 98.0
- Lexical Diversity: 1.25
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12668918', '14192131', '13917745', '14747485', '14725683']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8075641302049228
- 35 USC 102 Novelty (BERT): 0.528282905205875
- Combined Prediction Score: 0.779636007705018
- Mean Citation Score: 313.98425400000013
- Max Citation Score: 358.68304
- Similarity Product: 277.70860157377246

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test