PATENT CLAIM ANALYSIS

Application Number: 15986727
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "476000"]

Abstract:
In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a toxin including an acylfulvene or a drug moiety. The affinity moiety can be an antibody, a binding protein, a steroid, a lipid, a growth factor, a protein, a peptide or non peptidic. The affinity moiety can be covalently bound to the medicant via a linker. Novel linkers that can be directed to cysteine, arginine or lysine residues based on solution pH allow greater flexibility in preserving and/or generating specific epitopes in the AMC.

Claim (Index 7):
The compound of  claim 1 , where R 6  is generated from the group of reagents consisting of chemical reagents listed in Table IA, IB, IC, IIA, IIB, IIC, IID, IIIA, IIIB, IIIC, IVA, IVB, IVC, VIA, VIB and VIC, consisting essentially of 2-iminothiolane, methyl 4-mercaptobutyrimidate, N-(\u03b1-maleimidoacetoxy)-succinimide ester, N-\u00df-malemidopropionic acid, N-\u00df-(malemidopropyloxy)succinimide ester, C6-succinimidyl 4-formylbenzoate, N-acetylhomocysteinethiolactone, disuccinimidyl tartrate, N-(episilon-maleimidocaproic acid) hydrazide, N-(episilon-maleimideocaproyloxy)succinimide ester, N-(gamma-maleimideobutyrloxy)succinimide ester, N-kappa-maleimidoundecanoic acid, N-(kappa-maleimidoundecanoic acid) hydrazide, succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate), succinimidyl 6-(3\u2032-(2-pyridyl-dithio)propionamido)hexanoate, m-maleimidobenzoyl-N-hydroxysuccinimide ester, methyl 3-mercaptopropionimidate, 4-(4-N-maleimidophenyl)-butyric acid hydrazide, 4-(N-maleimidomethyl)cyclohexane-1-1 carboxyl-hydrazide, p-nitrophenyl iodoacetate, 3-(2-pyridyldithio)propionyl hydrazide, 3-2(pyridyldithio)propionate, N-(p-maleimidophenyl)isocyanate, succinimidyl S-acetylthioacetate, succinimidyl acetyithiopropionate, succinimidyl p-formylbenzoate, succinimidyl p-formylphneoxyacetate, succinimidyl 4-hydrazidoterephthalate, N-succinimidyl(4-iodoacetyl)-aminobenzoate, succinimidyl 4-(((iodoacetyl)amino)methyl)-cyclohexane-1-caroxylate, succinimidyl 6-((((4(iodoacetyl)amino)methyl)-cyclohexane-1-carbonyl)aminohexanoate, succinimidyl 6-((iodoacetyl)amino)hexanoate, succinimidyl 6-(6-(((iodoacetyl)amino)-hexanoyl)aminohexanoate, S-acetylmercaptosuccinic anhydride, succinimidyl 4-(N-maleimidomethyl)-cyclohexane-1-carboxylate, NHS-PEQ 2 -maleimide or maleimide PEG2 N-hydroxysuccinimide, NHS-PEO 4 -maleimide or maleimide PEG4 N-hydroxysuccinimide, NHS-PEO 8 -maleimide or maleimide PEG6 N-hydroxysuccinimide, NHS-PEO 12 -mleimide or maleimide PEG8 N-hydroxysuccinimide, succinimidyl 4-(para-maleimido-phenyl)butyrate, succinimidyl-6-(beta-maleimidopropionamido)hexanoate, 4-succinimidyloxycarbonyl-methyl-alpha-(2-pyridyldithio)toluene, N-succinimidyl 3-(2-pyridyldithio)propionate, sulfo-disuccinimidyl tartrate, N-(episilon-maleimidocaproyloxy)sulfosuccinimide, N-(gamma-maleimidobutyrloxy)sulfosuccinimide ester, N-(kappa-maleimidoundecanoyloxy) sulfosuccinimide ester, sulfosuccinimidyl 6-(alpha-methyl-alpha-(2-[pyridyldithio)-toluamido)hexanoate, sulfosuccinimidyl 6-(3\u2032-(2-pyridyl-dithio)propionamido)hexanoate, m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester, sulfo-succinimidyl(4-iodoacetyl)-aminobenzoate, sulfosuccimidyl 4-(N-maleimido-methyl)cyclohexane-1-carboxylate, sulfosuccimidyl 4-(p-maleimidophenyl)butyrate, N-5-azido-2-nitrobenzyloxy-succinimide, N-hydroxysuccinimidyl-4-azidosalicylic acid, N-succinimidyl (4\u2032-azidophenyl) 1,3\u2032-dithiopropionate, N-succinimidyl 6-(4\u2032 azido-2\u2032-nitrophenylamino)hexanoate, succinimidyl-(4-psoralen-8y;oxy)butyrate, N-hydroxysulfosuccinimidyl-4-azdobenzoate, sulfosuccinimidyl(4-azido-salicylamido)hexanoate, sulfosuccinimidyl(4-azido-phenyldithio)propionate, sulfosuccinimidyl 2-(7-azido-4-methylcoumarin-3-acetamido)ethyl-1,3\u2032-dithiopropionate, sulfosuccinimidyl 2-(p-azido-salicylamido)ethyl 1,3\u2032-dithiopropionate, sulfosuccinimidyl(perfluoroazidobenzamido)ethyl 1,3\u2032-dithiopropionate, sulfosuccinimidyl-2-(m-azido-o-nitrobenzamido)ethyl 1,3\u2032-dithiopropionate, sulfosuccinimidyl 6-(4\u2032-azido-2\u2032-nitrophenylamino)hexanoate, bis(sulfosuccinimidyl)glutarate-d0, bis(sulfosuccinimidyl) 2,2,4,4,glutarate-d4, bis(sulfosuccinimidyl)suberate, bis(sulfosuccinimidyl)suberate, bis(sulfosuccinimidyl)2,2,7,7-suberate-d4, bis(NHS)PEO5, bis(2-(succininidoxycarbonyloxy) ethyl)sulfone, dimethyl adipimidate, dimethyl pimelimidate, dimethyl suberimidate, 1,5,-difluoro-2,4-dinitrobenzene, 4,4\u2032-difluoro-3,3\u2032-dinitrophenylsulfone, disuccinimidyl glutarate, disuccinimidyl suberate, disuccinimidyl tartarate, dithiobis(succimidylpropionate), dimethyl 3,3\u2032-dithiobispropionimidate, 3,3\u2032-dithio-bis(sulfosuccinimidylpropionate), ethylene glycol bis(succinimidylsuccinate), N-(4-lsocyanatophenyl)maleimide, ethylene glycol bis(sulfo-succinimidylsuccinate), C6-succinimidyl 4-hydraznonicotinate acetone hydrazone, succinimidyl 4-hydraznonicotinate acetone hydrazone, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride, N-\u00df-maleimidopropionic acid) hydrazide, 4-(N-maleimidomethyl)cyclohexane-1-1carboxyl-hydrazide, 2-acetamido-4-mercaptobutyric acid hydrazide, p-azidobenzoyl hydrazide, 4-(p-azidosalicylamido)-butylamine, 1-cyclohexyl-3-2(2-morpholinoethyl)carbodiimide, adipic acid dihydrazide, N-ethyl-3-phen ylisoxazolium-3\u2032sulfonate, 1,3-diamonourea, succinimidyl 3-bromoacetamido)propionate, N-succinimidyl iodacetate, 1,4-di(3\u2032-(2\u2032pyridyldithio) propionamido)butane, dithio-bis-(sulfosuccinimidylpropionate), N-(4-(p-azidosalicylamido) butyl)-3\u2032-(2\u2032-pyridyldithio)propionamide.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 1.66176
- Patent Class: 514.0
- Transitional Phrase Type: half
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15201301', '14684218', '14875476', '13397205', '11342937']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8352571616110248
- 35 USC 102 Novelty (BERT): 0.6391188825011205
- Combined Prediction Score: 0.8156433337000344
- Mean Citation Score: 491.007214
- Max Citation Score: 758.3846
- Similarity Product: 530.2969378816247

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test