PATENT CLAIM ANALYSIS

Application Number: 16068627
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["544", "360000"]

Abstract:
The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represented by formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvent compound, or prodrug thereof, and a preparation method therefor and an application thereof. Refer to the specification for definitions of each group in the

Claim (Index 1):
A compound of formula (II), or a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof: wherein R 1 , R 2 , R 3 , R 4  are each independently a hydrogen, hydroxyl, CN, NO 2 , halogen, \u2014NR a R b , C 1-20  alkyl, C 3-20  cycloalkyl, C 3-20  cycloalkoxy, C 2-20  alkenyl, C 2-20  alkynyl, C 1-20  alkoxy, \u2014CHO, \u2014CO\u2014(C 1-20  alkyl), \u2014CO\u2014(C 6-20  aryl), C 6-20  aryl, \u2014CONR a R b , \u2014C(O)O\u2014(C 1-20  alkyl), \u2014OC(O)\u2014(C 1-20  alkyl), \u2014SO 2 -(C 1-20  alkyl) or \u2014SO 2 \u2014(C 6-20  aryl); R 5  is a hydrogen, C 1-20  alkyl, C 3-20  cycloalkyl, halogenated C 1-20  alkyl; R 6  is a C 3-10  cycloalkyl or C 3-8  heterocyclyl, and the C 3-8  heterocyclyl contains 1 to 3 heteroatoms selected from N, O, S; is selected from L 1  is attached at any different positions on the ring and is a bond, or \u2014C(O)N(R y )\u2014, \u2014N(R y )C(O)\u2014, \u2014N(R y )SO 2 \u2014, \u2014SO 2 N(R y )\u2014, \u2014OC(O)\u2014, \u2014C(O)O\u2014, \u2014(CR y R x ) r1 (O) r2 (CR y R x ) r3 -, \u2014S(O)\u2014, \u2014SO 2 \u2014, \u2014N(R y )\u2014, \u2014O\u2014, \u2014S\u2014, \u2014C(O)\u2014 or cyclopropylidene; wherein R y , R x  are each independently a hydrogen, halogen, hydroxyl, CN, NO 2 , C 1-20  alkyl, halogenated C 1-20  alkyl, C 3-20  cycloalkyl, C 2-20  alkenyl, C 2-20  alkynyl or C 6-20  aryl; r1, r3 are each independently 0, 1, 2 or 3; r2 is 0 or 1; each R 0  is the same or different and is each independently a hydrogen, deuterium, C 1-20  alkyl, deuterated C 1-20  alkyl or halogenated C 1-20  alkyl; or any two R 0  are connected through a single bond or \u2014(CH 2 ) p1 -, and p1 is 1, 2 or 3; A is a C 6-20  aryl, 3 to 7 membered monocyclic ring, 8 to 10 membered bicyclic ring, 3 to 7 membered mono heterocyclic ring, 8 to 10 membered bis-heterocyclic ring, 5 or 6 membered monocyclic heteroaryl ring, 8 to 10 membered bicyclic heteroaryl ring, benzo 3-7 membered monocyclic ring, benzo 3-7 membered mono heterocyclic ring, condensed ring of 5-6 membered monocyclic heteroaryl ring and 3-7 membered monocyclic ring, condensed ring of 5-6 membered monocyclic heteroaryl ring and 3-7 membered mono heterocyclic ring; wherein the alkyl, cycloalkyl, cycloalkoxy, alkenyl, alkynyl, alkoxy, aryl, 3 to 7 membered monocyclic ring, 8 to 10 membered bicyclic ring, 3 to 7 membered mono heterocyclic ring, 8 to 10 membered bis-heterocyclic ring, 5 or 6 membered monocyclic heteroaryl ring, 8 to 10 membered bicyclic heteroaryl ring, benzo 3-7 membered monocyclic ring, benzo 3-7 membered mono heterocyclic ring, condensed ring of 5-6 membered monocyclic heteroaryl ring and 3-7 membered monocyclic ring, or condensed ring of 5-6 membered monocyclic heteroaryl ring and 3-7 membered mono heterocyclic ring is substituted or unsubstituted; and the substitution means that 1-5 hydrogens in the group is substituted by a substituent selected from the group consisting of a halogen, nitro, hydroxyl, cyano, C 6-20  aryl, C 1-20  alkyl, halogenated C 1-20  alkyl, C 1-20  alkoxy, halogenated C 1-20  alkoxy, C 3-20  cycloalkyl, halogenated C 3-20  cycloalkyl, C 3-20  cycloalkoxy, halogenated C 3-20  cycloalkoxy, C 2-20  alkenyl, halogenated C 2-20  alkenyl, C 2-20  alkynyl, halogenated C 2-20  alkynyl, C 1-20  alkylthio, halogenated C 1-20  alkylthio, C 1-20  alkylamino, halogenated C 1-20  alkylamino, thiol, 3 to 20 membered heterocycloalkyl, 3 to 20 membered heterocycloalkyloxy, C 3-20  cycloalkylthio, halogenated C 3-20  cycloalkylthio, 3 to 20 membered heterocycloalkylthio, oxo, C 1-20  hydroxyalkyl, carboxyl, \u2014NR a R b , \u2014C(O)NR a R b , \u2014N(R a )C(O)\u2014(C 1-20  alkyl), \u2014N(R a )SO 2 \u2014(C 1-20  alkyl), \u2014SO 2 N(R a R b ), \u2014C(O)O\u2014(C 1-20  alkyl), \u2014CHO, \u2014C(O)\u2014(C 1-20  alkyl), \u2014SO 2 \u2014(C 1-20  alkyl), \u2014SO 2 \u2014(C 6-20  aryl), \u2014CO\u2014(C 6-20  aryl); and R a , R b  are each independently a hydrogen, C 1-20  alkyl, C 3-20  cycloalkyl or C 6-20  aryl.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.57447
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16308790', '15537002', '15799771', '15296601', '12588882']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7938274518031279
- 35 USC 102 Novelty (BERT): 0.5309340963605984
- Combined Prediction Score: 0.7675381162588749
- Mean Citation Score: 330.6311199999999
- Max Citation Score: 357.7838
- Similarity Product: 293.0474967069864

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test