PATENT CLAIM ANALYSIS

Application Number: 16260744
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-08
Patent Classification: ["544", "265000"]

Abstract:
The present invention relates to compounds of formula (I), wherein R 1 , R 2  and R 3  are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Claim (Index 1):
A compound of formula (I), wherein: R 1  is C 1-6 alkyl; R 2  is benzyl, said benzyl being unsubstituted or substituted by one, two or three substituents independently selected from halogen and C 1-6 alkyl; R 3  is \u2014NR 4 R 5 , wherein:\n R 4  is C 1-6 alkyl or C 1-6 alkoxyC 1-6 alkyl; \n R 5  is (C 1-6 alkyl) 2 NCOOC 1-6 alkyl, C 1-6 alkoxyC 1-6 alkyl, \n C 1-6 alkoxycarbonyl(C 1-6 alkyl)aminoC 1-6 alkyl, \n C 1-6 alkoxycarbonyl(phenyl)C 1-6 alkyl, C 1-6 alkoxycarbonylC 1-6 alkyl, \n C 1-6 alkoxycarbonyloxyC 1-6 alkyl, C 1-6 alkyl, \n C 1-6 alkylcarbonyl(C 1-6 alkyl)aminoC 1-6 alkyl or pyrrolidinylcarbamoyloxyC 1-6 alkyl; or \n R 4  and R 5  together with the nitrogen they are attached to form a heterocyclyl; \n or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof; with the proviso that: 6-amino-9-benzyl-2-(propylsulfonimidoyl)-7-(pyrrolidine-1-carbonyl)purin-8-one; 6-amino-9-benzyl-7-(piperidine-1-carbonyl)-2-(propylsulfonimidoyl)purin-8-one; 6-amino-9-benzyl-7-(morpholine-4-carbonyl)-2-(propyl sulfonimidoyl)purin-8-one; 6-amino-9-benzyl-7-(3,3-dimethylpyrrolidine-1-carbonyl)-2-(propylsulfonimidoyl)purin-8-one; ethyl 1-[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]pyrrolidine-2-carboxylate; 6-amino-7-(2-azaspiro[3.3]heptane-2-carbonyl)-9-benzyl-2-(propylsulfonimidoyl)purin-8-one; 6-amino-9-benzyl-7-(2-oxa-6-azaspiro[3.3]heptane-6-carbonyl)-2-(propylsulfonimidoyl)purin-8-one; 6-amino-9-benzyl-7-(3,3-difluoropyrrolidine-1-carbonyl)-2-(propylsulfonimidoyl)purin-8-one; 6-amino-9-benzyl-7-(3-fluoro-3-methyl-pyrrolidine-1-carbonyl)-2-(propylsulfonimidoyl)purin-8-one; and their enantiomers, diastereomers, and pharmaceutically acceptable salts are excluded.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 99.0
- Lexical Diversity: 1.37838
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15689136', '15148309', '15621080', '14958619', '13395429']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7750062513472316
- 35 USC 102 Novelty (BERT): 0.6907330304592064
- Combined Prediction Score: 0.7665789292584291
- Mean Citation Score: 438.6716619999999
- Max Citation Score: 698.61176
- Similarity Product: 692.5765516527176

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test