PATENT CLAIM ANALYSIS

Application Number: 16228310
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["558", "070000"]

Abstract:
Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Claim (Index 1):
A compound of formula (III): wherein Z is a thiol, disulfide, unsubstituted or substituted pyridyldisulfide, unsubstituted or substituted amino, amino oxy, carboxy, aldehyde, ketone, azide, unsubstituted or substituted maleimido, haloacetyl, hydrazine, hydrazide or hydroxy group; Cb represents a cell-binding agent; n is an integer from 1 to 20; M is H, Na, K, N + R 1 R 2 R 3  or a pharmaceutical salt thereof; R 3  is absent, a linear alkyl having from 1 to 6 carbon atoms, branched or cyclic alkyl having from 3 to 6 carbon atoms, a linear, branched or cyclic alkenyl or alkynyl having from 2 to 6 carbon atoms, polyethyleneoxy unit of formula (OCH 2 CH 2 ) p , wherein p is an integer from 1 to about 1000; or R 1 , R 2  and R 3  are respectively a chain of atoms selected from the group consisting of C, N, O, S, Si, and P that optionally covalently connects to each other; and R 4 , and R 5 , are the same or different and are absent, H, a linear alkyl having from 1 to 6 carbon atoms, branched or cyclic alkyl having from 3 to 6 carbon atoms, linear, branched or cyclic alkenyl or alkynyl having from 2 to 6 carbon atoms, or polyethyleneoxy unit of formula (OCH 2 CH 2 ) p , wherein p is an integer from 1 to about 1000.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 98.0
- Lexical Diversity: 1.1875
- Patent Class: 558.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15118726', '16228130', '16228437', '14432073', '12433604']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8536701027497084
- 35 USC 102 Novelty (BERT): 0.679284019114206
- Combined Prediction Score: 0.8362314943861582
- Mean Citation Score: 642.8125
- Max Citation Score: 727.0148
- Similarity Product: 619.0259570813417

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test