PATENT CLAIM ANALYSIS

Application Number: 16046254
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-07
Patent Classification: ["514", "210160"]

Abstract:
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

Claim (Index 41):
A compound according to  claim 1 , or a pharmaceutically acceptable salt thereof, selected from:\n (2S)-2-Methyl-1-((R)-2-(3-methyl-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamido)propyl)pyrrolidin-1-ium formate; N-(2-(3-Azabicyclo[3.2.1]octan-3-yl)ethyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (R)\u2014N-(1-(Isoindolin-2-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; N-((2R)-1-(3-Azabicyclo[3.1.0]hexan-3-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (S)\u2014N-(1-Cyclopropyl-2-(pyrrolidin-1-yl)ethyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (R)\u2014N-(1-Cyclopropyl-2-(pyrrolidin-1-yl)ethyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (R)\u2014N-(1-(3,4-Dihydroisoquinolin-2(1H)-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (R)\u2014N-(1-(3-Phenylazetidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; D1: N\u2014((R)-1-((abs)-3-(Difluoromethoxy)piperidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; D2: N\u2014((R)-1-((abs)-3-(Difluoromethoxy)piperidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (R)\u2014N-(1-(5-Azaspiro[2.5]octan-5-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (R)\u2014N-(1-(6-Azaspiro[2.5]octan-6-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (R)\u2014N-(1-(Azepan-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (R)\u2014N-(1-(1-Azaspiro [3.3]heptan-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (R)\u2014N-(1-(5-Azaspiro[2.4]heptan-5-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; N\u2014((R)-1-(3-Azabicyclo[3.2.1]octan-3-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; 2-((R)-2-(4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamido)propyl)octahydrocyclopenta[c]pyrrol-2-ium formate; (R)\u2014N-(1-(3,4-dihydro-2,7-naphthyridin-2(1H)-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; N-((2R)-1-(3-Azabicyclo[3.2.0]heptan-3-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; D1: N\u2014((R)-1-((abs-1,5-cis)-6-Azabicyclo[3.2.0]heptan-6-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; D2: N\u2014((R)-1-((abs-1,5-cis)-6-Azabicyclo[3.2.0]heptan-6-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; N-((2R)-1-(6,6-Dimethyl-3-azabicyclo[3.1.0]hexan-3-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; (2S)-1-((R)-2-(3-Fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamido)propyl)-2-methylpyrrolidin-1-ium formate; N\u2014((R)-1-((S)-2-Methylpyrrolidin-1-yl)propan-2-yl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)picolinamide; 3-methyl-N\u2014((R)-1-((S)-2-methylpyrrolidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; N-((2R)-1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; and 3-fluoro-N\u2014((R)-1-((S)-2-methylpyrrolidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 95.0
- Lexical Diversity: 1.1
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15148907', '15148884', '15041375', '13522044', '15630200']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8078348483091926
- 35 USC 102 Novelty (BERT): 0.5610834191081856
- Combined Prediction Score: 0.783159705389092
- Mean Citation Score: 371.179274
- Max Citation Score: 437.58426
- Similarity Product: 373.8263650917434

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test