PATENT CLAIM ANALYSIS

Application Number: 16003517
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "475000"]

Abstract:
In alternative embodiments the invention provides compositions and methods for ameliorating diseases and conditions having a beta-amyloid component, including Alzheimer's disease (AD), Vascular Dementia (VD), dementia, pre-dementia, Cognitive Dysfunction Syndrome (CDS) and loss of cognition in humans and in non-human animal. In alternative embodiment the invention provides analogs of AB-007 and its acid form E64c (loxistatin), their preparation, and pharmaceutical compositions thereof and methods of making and using same. In alternative embodiments compositions of the invention are deuterated analogs of AB-007 (or E64d) and E64c (or loxistatin). In alternative embodiments compositions of the invention are metabolically blocked forms as compared to AB-007 and loxistatin. In alternative embodiments compositions of the invention are used to ameliorate (including treat, slow, reverse or prevent) a disease or condition which can be ameliorated by partial or complete inhibition of a cysteine protease, e.g., AD, VD, CDS. The invention also provides alternative dosage forms and formulations for AB-007 and loxistatin, and for compounds of this invention, which can be used e.g., to treat AD, VD and CDS, in humans and in non-human animals.

Claim (Index 45):
The method of  claim 44 , wherein the compound of Formula I or Formula II is conjugated to a chemical delivery system (CDS), or further comprises a chemical delivery system (CDS) selected from the group comprising a pyridinium, a 1,4 dihydrotrigonelline esters, or a dihydroquinoline or a dihydroisoquinoline,\n and optionally the pyridinium is selected from the group consisting of a 3-methyl-1-propylpyridinium, a 1-butyl-3-methylpyridinium and a 1-butyl-4-methylpyridinium.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 94.0
- Lexical Diversity: 2.3587
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13940016', '13504325', '15969328', '14928775', '10530137']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7047561415515475
- 35 USC 102 Novelty (BERT): 0.5101099631340514
- Combined Prediction Score: 0.685291523709798
- Mean Citation Score: 213.912342
- Max Citation Score: 224.98982
- Similarity Product: 142.89471072988988

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test