PATENT CLAIM ANALYSIS

Application Number: 15999117
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["424", "001890"]

Abstract:
Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.

Claim (Index 8):
The radiolabeled MGLL occupancy probe of  claim 7 , wherein the MGLL inhibitor has the structure of Formula (Ib): wherein L 3  is a bond, \u2014CH 2 \u2014, \u2014S(O) 2 \u2014, or \u2014C(O)\u2014; R 7  is phenyl; wherein R 7  is optionally substituted by one, two, or three moieties independently selected from R h ; R a  and R b  are independently selected, for each occurrence, from the group consisting of hydrogen and C 1-3 alkyl; wherein C 1-3 alkyl is optionally substituted by one or more substituents selected from halogen, cyano, oxo, hydroxyl, heterocycle, and phenyl; or R a  and R b , when they occur together with the nitrogen to which they are attached, form a 4-6 membered saturated heterocyclic ring, which may have an additional heteroatom selected from O, S, and N, or a spirocyclic ring selected from 8-oxa-2-azaspiro[4.5]decane and 2,8-diazaspiro[4.5]decane, wherein the 4-6 membered saturated heterocyclic ring or the spirocyclic ring are optionally substituted by one or more substituents selected from the group consisting of halogen, cyano, oxo, C 1-6 alkyl, C 1-6 haloalkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1, or 2), hydroxyl, \u2014C(O)\u2014C 1-6 alkyl, \u2014NH 2 , and \u2014NH\u2014C(O)\u2014C 1-6 alkyl; R c  is selected from the group consisting of halogen, hydroxyl, C 1-6 alkyl (optionally substituted by one, two, or three halogens), and C 1-6 alkoxy (optionally substituted by one, two, or three halogens); and R h  is selected from the group consisting of: halogen, phenyl (optionally substituted by one, two, or three moieties each independently selected from R c ), hydroxyl, cyano, C 1-6 alkyl (optionally substituted by one, two, or three halogens), C 1-6 alkoxy (optionally substituted by one, two, or three halogens), R a R b N\u2014, R a \u2014C(O)NR a \u2014, R a R b N\u2014SO 2 \u2014, R a R b N\u2014C(O)\u2014, R a \u2014S(O) w \u2014 (wherein w is 0, 1, or 2), R a \u2014SO 2 \u2014NR b \u2014, and heteroaryl (optionally substituted by one, two, or three moieties each independently selected from R c ); or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, or stereoisomer thereof.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 96.0
- Lexical Diversity: 1.48387
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13043956', '13479826', '14003547', '14764426', '13391402']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7716995549716521
- 35 USC 102 Novelty (BERT): 0.4953765478892331
- Combined Prediction Score: 0.7440672542634102
- Mean Citation Score: 262.048626
- Max Citation Score: 265.28232
- Similarity Product: 214.84340313008312

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test