PATENT CLAIM ANALYSIS

Application Number: 16204730
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-08
Patent Classification: ["549", "456000"]

Abstract:
The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof: wherein X is an oxygen atom and the like; Y is —CO—, —SO 2 — and the like; R 1  is an optionally-substituted C 1-6  alkyl group, an optionally-substituted C 1-6  alkylcarbonyl group and the like; R 2  is an optionally-substituted C 1-6  alkyl group, an optionally-substituted C 1-6  alkoxy group, an optionally-substituted amino group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic saturated heterocyclic group and the like; R 3 , R 4 , R 5 , and R 6  are independently a hydrogen atom and the like which exhibits excellent effects in suppressing the proliferation and sphere-forming ability of cancer cells, and can be useful as an antitumor drug or cell growth inhibitor.

Claim (Index 1):
A compound of Formula (1): or a pharmaceutically acceptable salt thereof wherein\n X is an oxygen atom, a sulfur atom, or NR 7 ; \n Y is \u2014CO\u2014, \u2014CS\u2014, \u2014SO\u2014, or \u2014SO 2 \u2014; \n R 1  is a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally-substituted C 1-6 , alkyl group, an optionally-substituted C 1-6  alkoxy group, an optionally-substituted amino group, an optionally-substituted C 1-6  alkylcarbonyl group, an optionally-substituted C 3-10  cycloalkyl group, an optionally-substituted C 3-10  cycloalkylcarbonyl group, an optionally-substituted 3- to 8-membered saturated heterocyclic group, an optionally-substituted 3- to 8-membered saturated heterocyclic carbonyl group, an optionally-substituted C 6-10  aryl group, an optionally-substituted C 6-10  arylcarbonyl group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, or an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroarylcarbonyl group; \n R 2  is a hydrogen atom, a hydroxy group, an optionally-substituted C 1-6  alkyl group, an optionally-substituted C 1-6  alkoxy group, an optionally-substituted amino group, an optionally-substituted C 3-10  cycloalkyl group, an optionally-substituted 3- to 8-membered saturated heterocyclic group, an optionally-substituted C 6-10  aryl group, or an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group; \n R 3 , R 4 , R 5 , and R 6  are independently a hydrogen atom, a halogen atom, a cyano group, a nitro group, a hydroxy group, an optionally-substituted C 1-6  alkyl group, an optionally-substituted C 2-6  alkenyl group, an optionally-substituted C 2-6  alkynyl group, an optionally-substituted C 1-6  alkoxy group, an optionally-substituted C 1-6  alkylthio group, an optionally-substituted C 6-10  arylthio group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroarylthio group, an optionally-substituted C 1-6  alkylsulfinyl group, an optionally-substituted C 6-10  arylsulfinyl group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroarylsulfinyl group, an optionally-substituted C 1-6  alkylsulfonyl group, an optionally-substituted C 6-10  arylsulfonyl group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroarylsulfonyl group, an optionally-substituted amino group, an optionally-substituted C 1-6  alkylcarbonyl group, an optionally-substituted C 3-10  cycloalkyl group, an optionally-substituted C 3-10  cycloalkenyl group, an optionally-substituted 3- to 8-membered saturated heterocyclic group, an optionally-substituted C 6-10  aryl group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, a C 1-6  alkylsulfinyl group, an optionally-substituted C 3-10  cycloalkylsulfinyl group, an optionally-substituted C 1-6  alkylsulfonyl group, or an optionally-substituted C 3-10  cycloalkylsulfonyl group; and \n R 7  is a hydrogen atom, an optionally-substituted C 1-6  alkyl group, an optionally-substituted C 1-6  alkylcarbonyl group, an optionally-substituted C 3-10  cycloalkyl group, an optionally-substituted 3- to 8-membered saturated heterocyclic group, an optionally-substituted C 6-10  aryl group, or an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group; \n provided that the following compounds are excluded: \n the compounds wherein Y is \u2014CO\u2014 and R 1  is a methyl group, 3-(furan-2-carbonyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, 3-(2-naphthoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, ethyl 4,9-dioxo-2-(trifluoromethyl)-4,9-dihydronaphtho[2,3-b]furan-3-carboxylate, 3-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbonyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, 3-isonicotinoyl-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, 3-(benzo[d][1,3]dioxole-5-carbonyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, 3-(4-methoxybenzoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, 3-(3,4-dimethoxybenzoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, 3-benzoyl-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, 3-(4-bromobenzoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, 2-(trifluoromethyl)-3-(3,4,5-trimethoxybenzoyl)naphtho[2,3-b]furan-4,9-dione, 3-(4-fluorobenzoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, and 3-(thiophene-2-carbonyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 98.0
- Lexical Diversity: 1.87179
- Patent Class: 549.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15116850', '15561828', '13380376', '15112070', '10662165']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7572432237182221
- 35 USC 102 Novelty (BERT): 0.6043667439674751
- Combined Prediction Score: 0.7419555757431474
- Mean Citation Score: 359.027526
- Max Citation Score: 548.2676
- Similarity Product: 472.0347772536278

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test