PATENT CLAIM ANALYSIS

Application Number: 15912438
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "468000"]

Abstract:
The present invention provides controlled release dosage formulations of compounds having the Formula: or pharmaceutically acceptable salts thereof, and in particular, aplindore. The dosage forms are useful, inter alia, for reducing side effects from administration of such compounds.

Claim (Index 14):
A controlled release oral dosage formulation comprising aplindore, or a pharmaceutically acceptable salt thereof;\n wherein the aplindore, or the pharmaceutically acceptable salt thereof of the controlled release oral dosage formulation, is released at a rate effective to provide a C max -of about 4,000 pg/mL to about 14,000 pg/mL; and wherein the aplindore, or the pharmaceutically acceptable salt thereof of the controlled release oral dosage formulation is released at a rate to provide an AUC 0-12  of about 36,000 pg*h/mL to about 109,000 pg*h/mL; and wherein the controlled release oral dosage formulation comprises a microparticle wherein the microparticle comprises an inert core; a layer comprising the aplindore or the pharmaceutically acceptable salt thereof disposed on the inert core; and a coating comprising at least one release rate controlling polymer disposed on the layer of the compound; or wherein the controlled release oral dosage formulation comprises a microparticle, wherein the microparticle comprises a core that comprises the aplindore or the pharmaceutically acceptable salt thereof and at least one release rate controlling polymer; and a coating layer disposed on the core wherein the coating layer optionally comprises at least one release rate controlling polymer.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 90.0
- Lexical Diversity: 1.21622
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13498751', '11846896', '10269551', '14611372', '12706429']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.741593934452339
- 35 USC 102 Novelty (BERT): 0.516785152296434
- Combined Prediction Score: 0.7191130562367485
- Mean Citation Score: 282.302014
- Max Citation Score: 312.4602
- Similarity Product: 222.2814399285793

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test