PATENT CLAIM ANALYSIS

Application Number: 16064276
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "294000"]

Abstract:
Newly synthesized derivatives of BAS00127538 have been discovered to possess antibiotic activity and to combat resistant bacterial strains. Compounds and pharmaceutical compositions containing these compounds are described, and are based on a generic scaffold structure. Synthetic methods and methods of using the compounds also are described. Preferred compound 6jc48-1 ((E)-2,4-bis(4-bromophenyl)-6-(4-(dimethyl-amino)styryl)pyrylium boron tetrafluoride salt) binds to Lipid II with high affinity, has markedly reduced cytotoxicity than BAS00127538, and retains activity against drug-resistant strains of  Enterococci . It is stable in plasma, has dramatically improved pharmacokinetic and pharmacodynamics properties, and possesses in vivo efficacy in a mouse model of sepsis.

Claim (Index 9):
The compound of  claim 1 , which is selected from the group consisting of compounds 6jc48-1, 6jc58, 6jc66-3, 6jc66-4, 6jc67, 6jc77-1, 6jc77-2, 7jc46-1, 7jc47-1, and 7jc47-2.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 94.0
- Lexical Diversity: 1.45882
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15744922', '15312614', '12702937', '11362451', '13658103']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.793959982601044
- 35 USC 102 Novelty (BERT): 0.5217914438784871
- Combined Prediction Score: 0.7667431287287882
- Mean Citation Score: 280.29145600000004
- Max Citation Score: 286.79642
- Similarity Product: 180.5923737158513

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test