PATENT CLAIM ANALYSIS

Application Number: 15983079
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["544", "238000"]

Abstract:
The present invention relates to the field of biomedicine, and discloses a class of selenium-containing inhibitors that bind to the allosteric site of glutaminase, and/or inhibit glutamate dehydrogenase, which has a long carbon chain or similar derivative structure linked with the N atom of benzoisoselenazole 3-ketone. The advantages of this invention are that compounds have novel binding activity with glutaminase and potent inhibitory activity of glutaminase. Moreover, some novel dual KGA/GDH inhibitors demonstrated good in vivo efficacy in inhibiting the tumor growth in mice by blocking glutaminolysis. At the meantime, compounds of this invention play an important part in the protection of survival, growth and differentiation of nerve cells under the condition of hypoxia-ischemia.

Claim (Index 12):
A composition of selenium-containing inhibitors that bind to the allosteric site of glutaminase and/or inhibit glutamate dehydrogenase comprising a general formula as follows: wherein: X 1  comprising a linear or branched carbon chain containing 4-7 C, Hydroxylpyperidine,Pyrrolidine,Aminopyperidine,m-phenyldiamine,or 3-7 membered cycle group, R 3  comprising C, N, O, S, Se, aromatic heterocycle, heterocycle, thiodiazole, tetrazole, triazole or related derivatives thereof, R 4 , R 5  are independently selected substituents comprising H, C, N, O, S, Se atom, aromatic heterocycle, heterocycle, aromatic group, cycle group, substituted alkyl, lipid, or through amide, ether, halogen, silane, thioether, amine, phosphate group, sulfoxide, or related derivatives thereof.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 93.0
- Lexical Diversity: 1.53086
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12433604', '14080377', '13542126', '14773686', '14713419']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7308349883886592
- 35 USC 102 Novelty (BERT): 0.5101724490779195
- Combined Prediction Score: 0.7087687344575853
- Mean Citation Score: 250.483648
- Max Citation Score: 258.1949
- Similarity Product: 171.20663849344254

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test