PATENT CLAIM ANALYSIS

Application Number: 15771430
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "400000"]

Abstract:
A first aspect of the invention relates to novel compounds and more precisely to novel bifunctional prodrugs and drugs. An additional aspect of the invention relates to antibody compound conjugates, wherein the compound is a claimed compound, and to pharmaceutical compositions containing the compound or antibody compound conjugate. The invention lastly relates to the use of this compound or antibody compound conjugates according to the invention in order to treat tumour diseases, particularly in mammals.

Claim (Index 1):
A compound of the general structure A-L-B, where A and B independently of one another are formed from the structure I in which Hal is a halide selected from F, Cl, Br, I;\n R is H or an optionally substituted C 1 -C 4  alkyl group, an optionally substituted C 1 -C 4  alkoxy group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C 1 -C 4  alkylcarboxyl-C 1 -C 4  alkyl group, Hal, CN, an optionally substituted C 1 -C 4  alkylsulfanyl group, an optionally substituted arylsulfanyl group, a group \n NR z  as defined below; \n R 1  is H or a C 1 -C 4  alkyl group or a C 1 -C 4  alkoxy group; \n X 1  is O, S, NR 5 , where R 5  is selected from H and optionally substituted C 1 -C 4  alkyl; \n R 2  is selected from hydrogen, or a cleavable substrate, more particularly cleavable enzymatically or cleavable by chemical reaction including a substrate which is cleavable with acid catalysis; \n G independently at each occurrence is absent or is hydrogen or a functional group selected from the group consisting of an alkyne group, an amino group, a hydroxyl group, a thiol group, a carboxyl group, an azide group or a polyglycine group, where the functional group G is present at least once in the compound A-L-B; \n L is a linker for the covalent linkage of A and B, where L has the structure Z\u2014Y\u2014Z\u2032; where Z and Z\u2032 independently of one another are selected from C\u2550O, OC\u2550O, SO 2 , NR z , NR Z C\u2550O, and C\u2550ONR z , where each R Z  independently of any other is hydrogen, optionally substituted C 1 -C 4  alkyl or optionally substituted C 1 -C 4  acyl; and where Y is selected from a structure according to structure III or structure IV; \n where each R A  independently of any other is hydrogen, optionally substituted C 1 -C 4  alkyl or optionally substituted C 1 -C 4  acyl;\n o and p independently of one another are selected from an integer from 1 to 20; where o and p may adopt the same value or a different value; \n G is as defined above; \n X 2  is i) N or S or ii) an aryl or heteroaryl group, where (CR A ) o  and (CR A ) p  are located at meta at the aryl group or at the heteroaryl group, \n R 3  is C 1 -C 10  alkyl, C 0 -C 4  alkylaryl C 0 -C 10  alkyl group, C 0 -C 4  alkylheteroaryl C 0 -C 10  alkyl group, a cleavable substrate; or is not present; and \n R 4  is\n i) absent or is a C 1 -C 10  alkyl group, a C 0 -C 4  alkylaryl C 0 -C 10  alkyl group; a C 0 -C 4  alkylheteroaryl C 0 -C 10  alkyl group, a cleavable substrate, or \n ii) R 4  is a C 1 -C 10  alkyl group, a cleavable substrate, or is absent if X 2  is an aryl or heteroaryl group; \n \n and pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof.

Metadata:
- Claim Count in Document: 36.0
- Percentile: 91.0
- Lexical Diversity: 1.84091
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14526462', '11997981', '12204082', '10534777', '13641219']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7633572819996151
- 35 USC 102 Novelty (BERT): 0.5155257461478452
- Combined Prediction Score: 0.738574128414438
- Mean Citation Score: 260.520772
- Max Citation Score: 270.90814
- Similarity Product: 184.22478731285568

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test