PATENT CLAIM ANALYSIS

Application Number: 16059871
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["800", "018000"]

Abstract:
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

Claim (Index 31):
The method of  claim 28 , wherein the one or more human V H  gene segments are selected from the group consisting of V H 6-1, V H 1-2, V H 1-3, V H 2-5, V H 3-7, V H 1-8, V H 3-9, V H 3-11, V H 3-13, V H 3-15, V H 3-16, V H 1-18, V H 3-20, V H 3-21, V H 3-23, V H 1-24, V H 2-26, V H 4-28, V H 3-30, V H 4-31, V H 3-33, V H 4-34, V H 3-35, V H 3-38, V H 4-39, V H 3-43, V H 1-45, V H 1-46, V H 3-48, V H 3-49, V H 5-51, V H 3-53, V H 1-58, V H 4-59, V H 4-61, V H 3-64, V H 3-66, V H 1-69, V H 2-70, V H 3-72, V H 3-73, V H 3-74, and a combination thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 2.0
- Patent Class: 800.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16059884', '14192051', '14600829', '14682859', '13566765']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7360877793755758
- 35 USC 102 Novelty (BERT): 0.732953033075529
- Combined Prediction Score: 0.735774304745571
- Mean Citation Score: 836.444528
- Max Citation Score: 880.26184
- Similarity Product: 819.6978558127307

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test