PATENT CLAIM ANALYSIS

Application Number: 15877980
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["435", "195000"]

Abstract:
The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.

Claim (Index 22):
A polypeptide comprising a mutant dehalogenase that is capable of forming a covalent bond with a dehalogenase substrate, said mutant dehalogenase having at least 95% sequence identity with the amino acid sequence of SEQ ID NO: 1 with the exception of one or more positions corresponding to positions in SEQ ID NO: 1 selected from the group consisting of positions 5, 7, 11, 12, 20, 30, 32, 47, 54, 55, 56, 58, 60, 65, 78, 80, 82, 87, 88, 94, 96, 109, 113, 116, 117, 118, 121, 124, 128, 131, 134, 136, 144, 147, 150, 151, 155, 157, 160, 161, 164, 165, 167, 172, 175, 176, 180, 182, 183, 187, 195, 197, 204, 218, 221, 224, 227, 231, 233, 250, 256, 257, 263, 264, 273, 277, 280, 282, 288, 291, 292, and 294; wherein said mutant dehalogenase comprises substitutions corresponding to substitutions at:\n (a) one or more positions corresponding to positions in SEQ ID NO: 1 selected from the group consisting of positions 106 and 272; and (b) one or more positions corresponding to positions in SEQ ID NO: 1 selected from the group consisting of positions 58, 78, 155, 167, 172, 224, and 291.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.33333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15414291', '11978950', '14285327', '13863924', '14293766']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6168313681891378
- 35 USC 102 Novelty (BERT): 0.5794701518559586
- Combined Prediction Score: 0.6130952465558198
- Mean Citation Score: 467.35970400000014
- Max Citation Score: 493.6981
- Similarity Product: 405.8297976077199

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test