PATENT CLAIM ANALYSIS

Application Number: 15571475
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["514", "330000"]

Abstract:
Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.

Claim (Index 96):
A method of reducing the level of activity of a K-Ras protein, said method comprising contacting the K-Ras protein with a compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the formula: wherein, Y is N or CH Ring A is a C 3 -C 7  cycloalkyl or 3 to 7 membered heterocycloalkyl; R 1  is independently halogen, CX 1 3 , \u2014CHX 1 2 , \u2014CH 2 X 1 , \u2014CN, \u2014SO 2 Cl, \u2014SO n1 R 10 , \u2014SO v1 NR 7 R 8 , \u2014NHNR 7 R 8 , \u2014ONR 7 R 8 , \u2014NHC\u2550(O)NHNR 7 R 8 , \u2014NHC(O)NR 7 R 8 , \u2014N(O) m1 , \u2014NR 7 R 8 , \u2014C(O)R 9 , \u2014C(O)\u2014OR 9 , \u2014C(O)NR 7 R 8 , \u2014OR 10 , \u2014NR 7 SO 2 R 10 , \u2014NR\u2032C(O)R 9 , \u2014NR\u2032C(O)OR 9 , \u2014NR 7 OR 9 , \u2014OCX 1 3 , \u2014OCHX 1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; two adjacent R 1  substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L 1  is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene; L 2  is a bond, \u2014O\u2014, \u2014C(O)\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014S(O) 2 \u2014, \u2014NR 7B \u2014, \u2014NRBC(O)\u2014, \u2014C(O)NR 7B \u2014, \u2014SO 2 NR 7B \u2014, \u2014NR 7B SO 2 \u2014, \u2014OC(O)NR 7B \u2014, \u2014NR 7B C(O)O\u2014, \u2014CR 9B \u2550NO\u2014, \u2014ON\u2550CR 9B \u2014, \u2014NR 8B C(O)NR 7B \u2014, \u2014NR 8B C(\u2550NR 10B )NR 7B , \u2014NR 8B C(\u2550NR 10B )\u2014, \u2014C(\u2550NR 10B )NR 7B , \u2014OC(\u2550NR 10B ), \u2014C(\u2550NR 10B )O\u2014, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene; L 4  is a bond, \u2014O\u2014, \u2014C(O)\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014S(O) 2 \u2014, \u2014NR 4 \u2014, \u2014NR 4 C(O)\u2014, \u2014C(O)NR 4 \u2014, \u2014SO 2 NR 4 \u2014, \u2014NR 4 SO 2 \u2014, \u2014NR 4 SO 2 \u2014, \u2014OC(O)NR 4 \u2014, \u2014NR 4 C(O)O\u2014, substituted or unsubstituted C 1 -C 3  alkylene, substituted or unsubstituted 2 to 3 membered heteroalkylene; E is an electrophilic moiety; R 2  is independently oxo, halogen, CX 2 3 , \u2014CHX 2 2 , \u2014CH 2 X 2 , \u2014CN, \u2014SO 2 Cl, \u2014SO n2 R 14 , \u2014SO v2 NR 11 R 12 , \u2014NHNR 11 R 12 , \u2014ONR 11 R 12 , \u2014NHC\u2550(O)NHNR 11 R 12 , \u2014NHC(O)NR 11 R 12 , \u2014N(O) m2 , \u2014NR 11 R 12 , \u2014C(O)R 14 , \u2014C(O)\u2014OR 14 , \u2014C(O)NR 11 R 12 , \u2014OR 15 , \u2014NR 11 SO 2 R 15 , \u2014NR 11 C(O)R 14 , \u2014NR 11 C(O)OR 14 , \u2014NR 11 OR 14 , \u2014OCX 2 3 , \u2014OCHX 2 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; two adjacent R 2  substituents or two R 2  substituents bonded to the same atom may optionally be joined to form a substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl; R 4  is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; R 7 , R 8 , R 9 , R 10 , R 7B , R 8B , R 9B , R 10B , R 11 , R 12 , R 14 , and R 15  are independently hydrogen, halogen, \u2014CX 3 , \u2014CN, \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 2 Cl, \u2014SO 3 H, \u2014SO 4 H, \u2014SO 2 NH 2 , \u2014NHNH 2 , \u2014ONH 2 , \u2014NHC(O)NHNH 2 , \u2014NHC(O)NH 2 , \u2014NHSO 2 H, \u2014NHC(O)H, \u2014NHC(O)OH, \u2014NHOH, \u2014OCX 3 , \u2014OCHX 2 , \u2014CHX 2 , \u2014CH 2 X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 7  and R 8  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R 11  and R 12  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; each X, X 1 , and X 2  is independently \u2014F, \u2014Cl, \u2014Br, or \u2014I; n1, n2, v1, and v2 are independently an integer from 0 to 4; m1 and m2 are independently an integer from 1 to 2; z1 is independently an integer from 0 to 5; and z2 is independently an integer from 0 to 10.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 93.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15382942', '15950953', '15757238', '15662861', '15700040']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.846266472419814
- 35 USC 102 Novelty (BERT): 0.5835897691882408
- Combined Prediction Score: 0.8199988020966567
- Mean Citation Score: 535.581868
- Max Citation Score: 593.351
- Similarity Product: 392.91959856122736

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test