PATENT CLAIM ANALYSIS

Application Number: 16168671
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "04400A"]

Abstract:
This invention relates to compounds, compositions, and methods useful for reducing transth:yretin (TTR) target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.

Claim (Index 49):
The dsNA of  claim 4  comprising a modified nucleotide selected from the group consisting of a deoxyribonucleotide, a dideoxyribonucleotide, an acyclonucleotide, a 3\u2032-deoxyadenosine (cordycepin), a 3\u2032-azido-3\u2032-deoxythymidine (AZT), a 2\u2032,3\u2032-dideoxyinosine (ddI), a 2\u2032,3\u2032-dideoxy-3\u2032-thiacytidine (3TC), a 2\u2032,3\u2032-didehydro-2\u2032,3\u2032-dideoxythymidine (d4T), a monophosphate nucleotide of 3\u2032-azido-3\u2032-deoxythymidine (AZT), a 2\u2032,3\u2032-dideoxy-3\u2032-thiacytidine (3TC) and a monophosphate nucleotide of 2\u2032,3\u2032-didehydro-2\u2032,3\u2032-dideoxythymidine (d4T), a 4-thiouracil, a 5-bromouracil, a 5-iodouracil, a 5-(3-aminoallyl)-uracil, a 2\u2032-O-alkyl ribonucleotide, a 2\u2032-O-methyl ribonucleotide, a 2\u2032-amino ribonucleotide, a 2\u2032-fluoro ribonucleotide, and a locked nucleic acid.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 1.18182
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15102181', '14583200', '15616254', '15572663', '15044538']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8644888349325777
- 35 USC 102 Novelty (BERT): 0.717693898007219
- Combined Prediction Score: 0.8498093412400418
- Mean Citation Score: 733.447494
- Max Citation Score: 866.9187
- Similarity Product: 761.1234783428371

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test