PATENT CLAIM ANALYSIS

Application Number: 16225484
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "210180"]

Abstract:
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R 1 , R 2 , R 5 , and R 8  are as described herein.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt, enantiomer, hydrate, solvate, prodrug, isomer, or tautomer thereof, wherein: W is O, S, C(O), or CHR 3 ; X is N or CR 4 ; Y is N or CR 6 ; Z is N or CR 7 ; R 1  is hydrogen, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; R 2  is hydrogen or NR a R b ; R 3  is hydrogen, halogen, hydroxyl, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; R 4  is hydrogen, \u2014(CH 2 ) n R d , \u2014O(CH 2 ) n R d , \u2014N(CH 2 ) n R d , \u2014O(CH 2 ) n C(O)R d , or \u2014O(CH 2 ) n S(O) 2 R d ; R 5  and R 6  are each independently hydrogen, halogen, cyano, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, C 3 -C 8  cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, \u2014(C 1 -C 6 )-alkylene-aryl, \u2014(C 1 -C 6 )-alkylene-heteroaryl, \u2014(C 1 -C 6 )-alkylene-heterocycloalkyl, \u2014(CR a R b ) n OR c , \u2014(CR a R b ) n R c , \u2014O(CR a R b ) n NR a R b , \u2014NR a R b , \u2014NR a C(O)R b , \u2014NR a S(O) 2 R b , or R c , wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, and heteroaryl are optionally substituted with one or more substituents independently selected from R a , R b , and R c ; R 7  is hydrogen or halogen; R 8  is R a , \u2014OR a , \u2014NR a , or heterocycloalkyl; R a  and R b  are each independently hydrogen, halogen, C 1 -C 6  alkyl, cycloalkyl, or heterocycloalkyl, wherein C 1 -C 6  alkyl, cycloalkyl, or heterocycloalkyl is optionally substituted with one or more R e ; R c  is \u2014NH 2 , OH, \u2014NH(C 1 -C 6  alkyl), \u2014O(CH 2 ) n NR a R b , \u2014NH(C 1 -C 6  alkoxy), \u2014(CH 2 ) n R a , \u2014(CH 2 ) n OR a , \u2014C(O)R a , \u2014C(O)OR a , \u2014C(O)NR a R b , \u2014(CH 2 ) n S(O) 2 CH 3 , \u2014S(O) 2 R a , \u2014S(O) 2 NR a R b , \u2014NR a  S(O) 2 R b , \u2014NHC(O)R a , C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 1 -C 6  alkoxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, halo, cyano, or oxo, wherein C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 1 -C 6  alkoxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R e ; or two adjacent R e  can combine with the carbons to which they are attached to form a carbocycle or heterocycle; R d  is hydrogen, NH(C 1 -C 6  alkyl), N(C 1 -C 6  alkyl) 2 , C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 1 -C 6  alkoxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents independently selected from R a , R b , and R c ; R e  is hydrogen, halogen, OH, C 1 -C 6  alkyl, cycloalkyl, heterocycloalkyl, oxo, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 1 -C 6  alkoxy, or S(O) 2 (C 1 -C 6  alkyl); and n is 0, 1, or 2.

Metadata:
- Claim Count in Document: 115.0
- Percentile: 98.0
- Lexical Diversity: 1.37778
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14546775', '15937271', '14546896', '16029166', '16016955']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.821314003236271
- 35 USC 102 Novelty (BERT): 0.6889604314649106
- Combined Prediction Score: 0.8080786460591349
- Mean Citation Score: 488.26624
- Max Citation Score: 655.55743
- Similarity Product: 645.4994790368257

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test