PATENT CLAIM ANALYSIS

Application Number: 15774223
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["424", "233100"]

Abstract:
Compositions and methods are provided for modulating adeno-associated virus (AAV) infection. For example, compositions and methods are provided for enhancing permissiveness of a target cell to AAV infection (e.g., by increasing levels of AAVR (KIAA0319L) in the cell), for reducing permissiveness of a target cell to AAV infection (e.g., by reducing levels of AAVR in the cell), and for nucleic acid delivery (e.g., by (i) increasing permissiveness of a target cell to AAV infection, e.g., by increasing the amount of AAVR in the cell; and (ii) contacting the target cell with an AAV particle that includes a nucleic acid of interest). Also provided are screening methods and kits for practicing the methods of the disclosure.

Claim (Index 19):
A genetically modified mammalian cell with reduced permissiveness to adeno-associated virus (AAV) infection, comprising one or more of:\n (a) an altered nucleotide sequence at one or more endogenous genomic loci, wherein each of said one or more endogenous genomic loci encodes a target protein selected from: adeno-associated virus receptor (AAVR) (KIAA0319L), GPR108, TM9SF2, VPS29, VPS54, VPS52, and ATP2C1, wherein the altered nucleotide sequence is relative to a corresponding endogenous genomic locus of a corresponding wild type cell; and (b) one or more RNAi agents, or one or more nucleic acids encoding said one or more RNAi agents, wherein each of said one or more RNAi agents specifically targets expression of a target protein selected from: AAVR, GPR108, TM9SF2, VPS29, VPS54, VPS52, and ATP2C1; wherein (a) and (b), independently or combined, cause a reduced amount of one or more of said target proteins to be present in the genetically modified mammalian cell relative to the amount present in the absence of (a) and (b).

Metadata:
- Claim Count in Document: 56.0
- Percentile: 93.0
- Lexical Diversity: 2.66038
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10880297', '15367734', '15681267', '15435212', '13840224']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6983419686296359
- 35 USC 102 Novelty (BERT): 0.5232907430411164
- Combined Prediction Score: 0.680836846070784
- Mean Citation Score: 312.9323080000001
- Max Citation Score: 317.23126
- Similarity Product: 239.3137459942341

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test