PATENT CLAIM ANALYSIS

Application Number: 16095315
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["424", "489000"]

Abstract:
In the present invention, the whole preparation process of the sustained-release microparticles is at normal or low temperature, which is highly advantageous for the preparation of a polymer-based composition from a high-temperature-sensitive drug, particularly a protein, nucleic acid and peptide drug, and the bioactivity of the active substance can be maintained to the greatest extent throughout the process compared to the disclosed technology; at the same time, the prepared sustained-release microparticles have an excellent sustained-release effect close to zero order, and the drug concentration is stabilized during the release, which overcomes the defects that the microparticles obtained by the conventional S/O/W process of pre-preparing the drug microparticles have no drug release in the earlier stage and a rapid release of the drug in the later stage; and in addition, the sustained-release microparticles have higher drug loading rate and drug encapsulation rate.

Claim (Index 1):
A preparation method of sustained-release microparticles, characterized by comprising the following steps:\n 1) preparing a solid dispersion of a water-soluble drug and a biodegradable and biocompatible poorly water-soluble polymer; 2) dissolving the solid dispersion prepared in step 1) in an organic solvent C to form a solid dispersion emulsion, the organic solvent C being an organic solvent which is not capable of dissolving the water-soluble drug but capable of dissolving the poorly water-soluble polymer, has a boiling point lower than that of water and is insoluble or poorly soluble in water; 3) adding the solid dispersion emulsion obtained in step 2) into an surfactant-containing aqueous solution to form a uniform emulsion; and 4) solidifying microparticles in the emulsion by solvent volatilization or solvent extraction, collecting the microparticles, washing with ultrapure water several times to remove the surfactant attached to the surface of the microparticles, and drying to obtain the sustained-release microparticles.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 97.0
- Lexical Diversity: 1.88889
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14898415', '15444712', '13995727', '13472219', '12221096']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7313275696646874
- 35 USC 102 Novelty (BERT): 0.5004054153002742
- Combined Prediction Score: 0.7082353542282461
- Mean Citation Score: 254.79315000000005
- Max Citation Score: 275.04373
- Similarity Product: 218.552767060566

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test