PATENT CLAIM ANALYSIS

Application Number: 15994502
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-03
Patent Classification: ["514", "183000"]

Abstract:
The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to bisantrene or derivatives, analogs, or prodrugs thereof.

Claim (Index 23):
The composition of  claim 12  wherein the composition comprises bisantrene and is formulated for use in a program of selecting appropriate patient or disease genotypes for use of the composition wherein analysis of patient or disease genotype is carried out by a method selected from the group consisting of:\n (a) genetic tests to determine the absence or nonfunctionality of ABCG2; \n (b) genetic tests to determine the presence or functionality of FABP7; \n (c) use of a diagnostic tool, a diagnostic technique, a diagnostic kit, or a diagnostic assay to confirm a patient's particular genotype; \n (d) use of a gene chip; \n (e) use of gene expression analysis; \n (f) use of single nucleotide polymorphism (SNP) analysis; \n (g) measurement of the level of a metabolite or a metabolic enzyme; \n (h) determination of the presence of one or more specific genetic variants of the MDR1 gene associated with increased efficacy of an antineoplastic drug transported by MDR1 protein; \n (i) identification of one or more biomarkers associated with sensitivity or resistance to bisantrene, derivatives or analogs thereof, or other intercalating agents or topoisomerase II inhibitors; and \n (j) determination of the presence or absence of the single nucleotide polymorphisms (SNPs) rs229109 and/or 72552784 associated with sensitivity to bisantrene.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 1.31579
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15979041', '14907728', '14907729', '13817096', '14250958']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8179342805566241
- 35 USC 102 Novelty (BERT): 0.5311291673372303
- Combined Prediction Score: 0.7892537692346847
- Mean Citation Score: 276.52593
- Max Citation Score: 362.98706
- Similarity Product: 239.08914413036103

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test