PATENT CLAIM ANALYSIS

Application Number: 16105203
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["435", "194000"]

Abstract:
The present invention relates to the construction of a new class of Targeted Secretion Inhibitors (TSIs), which comprise a non-cytotoxic protease, translocation peptide and a targeting moiety peptide, wherein the targeting moiety peptide has a free N-terminal domain and a free C-terminal domain; to a single-chain fusion protein precursor thereof, and to a method of activating said single-chain fusion protein precursor.

Claim (Index 1):
A nucleic acid encoding a single-chain, polypeptide fusion protein, the fusion protein comprising:\n (a) a non-cytotoxic protease capable of cleaving a protein of the exocytic fusion apparatus of a target cell; (b) a targeting moiety capable of binding to a binding site on the target cell, which binding site is capable of undergoing endocytosis to be incorporated into an endosome within the target cell; (c) a translocation domain capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the target cell; (d) a first protease cleavage site at which site the fusion protein is cleavable by a first protease, wherein the first protease cleavage site is located between the non-cytotoxic protease and the translocation domain; (e) a second protease cleavage site at which site the fusion protein is cleavable by a second protease, wherein the second protease cleavage site is located between the translocation domain and the targeting moiety; and (f) a covalent linkage between the targeting moiety and the translocation domain; and wherein, following proteolytic cleavage at the second protease cleavage site, the targeting moiety remains linked to the translocation domain by the covalent linkage.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 96.0
- Lexical Diversity: 1.60465
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14117286', '13774587', '12862948', '13738235', '13239573']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6264899300343958
- 35 USC 102 Novelty (BERT): 0.5793861933562205
- Combined Prediction Score: 0.6217795563665783
- Mean Citation Score: 420.549464
- Max Citation Score: 466.78696
- Similarity Product: 445.4124991023492

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test