PATENT CLAIM ANALYSIS

Application Number: 16119962
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["544", "387000"]

Abstract:
The present invention relates to compounds and compositions for inhibition of FASN, their synthesis, applications, and antidotes.

Claim (Index 7):
A fatty acid synthase inhibitor compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1  is a 3 or 4 membered cycloalkyl or heterocycloalkyl wherein (i) the heteroatom ring member of the 3 or 4 membered heterocycloalkyl is independently selected from O, S, or N, and (ii) each of said 3 or 4 membered cycloalkyl or heterocycloalkyl is either unsubstituted or optionally substituted with substituents selected from the group consisting of \u2014R a , \u2014OR a , \u2014NHR a , and \u2014NR a R a1 ; L is a 6-membered monocyclic substituted heteroalkyl wherein the heteroatom ring members are independently selected from O, S, or N, and wherein the 6-membered monocyclic heteroalkyl is substituted with one or more substituents selected from \u2014R b ; A and B are independently O or S; Ar 1  is a 6-membered monocyclic aryl, heteroaryl or heterocycloalkyl, wherein (i) said 6-membered monocyclic heteroaryl or heterocycloalkyl have 1, 2, 3, or 4 heteroatoms which are independently selected from N, S or O, and (ii) each of said 6-membered monocyclic aryl, heteroaryl, or heterocycloalkyl is either unsubstituted or optionally independently substituted with 1 or more substituents which can be the same or different and are independently selected from the group consisting of halo, alkyl, \u2014CH z F 3-z , cyano, hydroxyl, hydroxylalkyl, amino, aminoalkyl-, (amino)alkoxy-, \u2014CONH 2 , \u2014C(O)NH(alkyl), \u2014C(O)N(alkyl) 2 , \u2014C(O)NH(aryl), \u2014C(O)N(aryl) 2 , \u2014OCH z F 3-z , -alkyl, -alkenyl, -alkynyl, -alkoxy (alkoxyalkyl)amino-, \u2014N(R)\u2014C(O)-alkyl, \u2014N(R c )\u2014C(O)-aryl, -cycloalkyl, -heterocycloalkyl, -aryl, and -heteroaryl, with the proviso that no two adjacent ring heteroatoms are both S or both O; R 2  is a 4-15 membered monocyclic, bicyclic or tricyclic aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, (i) the 4-15 membered monocyclic, bicyclic or tricyclic heteroaryl or heterocycloalkyl has 1, 2, 3, 4, 5, 6, 7 or 8 heteroatoms that are independently selected from N, S or O, and (ii) wherein each of said aryl, heteroaryl, cycloalkyl, or heterocycloalkyl is either unsubstituted or optionally substituted with 1 or more substituents which can be the same or different and are independently selected from the group consisting of halo, cyano, hydroxyl, hydroxyl-alkyl-, hydroxylcycloalkyl-, hydroxyl-heterocycloalkyl-, hydroxyl-aryl-, hydroxyl-heteroaryl-, amino, aminoalkyl, (amino)alkoxy-, \u2014CONH 2 , \u2014C(O)NH(alkyl), \u2014C(O)N(alkyl) 2 , \u2014C(O)NH(aryl), \u2014C(O)N(aryl) 2 , \u2014CH z F 3-z , \u2014OCH z F 3-z , -alkyl, alkoxy-, -alkenyl, -alkynyl, aryloxy-, (alkoxyalkyl)amino-, -cycloalkyl, -heterocycloalkyl, (heterocycloalkyl)alkyl-, -aryl, -heteroaryl, \u2014O(cycloalkyl), \u2014O(heterocycloalkyl), \u2014O(heteroaryl), ONH 2 , \u2014C(O)NH(cycloalkyl), \u2014NH(CO)cycloalkyl, \u2014NH(SO 2 ), \u2014NH(SO 2 )alkyl, \u2014NH(SO 2 )aryl, \u2014NH(SO 2 )heteroaryl, \u2014N(SO 2 )cycloalkyl, (aryl)alkyl-, -heteroaryl, (heteroaryl)alkyl-, \u2014S(O) 2 -alkyl, \u2014S(O) 2 -aryl, \u2014S(O) 2 -cycloalkyl, \u2014C(O)alkyl, \u2014NH\u2014C(O)-alkyl, NH\u2014C(O)\u2014 heterocycloalkyl, NH\u2014C(O)-heterocycloalkyl-R d \u2014NH\u2014C(O)\u2014R d , \u2014NH\u2014C(O)-aryl, \u2014NH\u2014C(O)\u2014NH-alkyl, NH\u2014C(O)\u2014NH-cycloalkyl, NH 2 (CO)cycloalkyl-, NH\u2014C(O)\u2014NH-aryl, \u2014NH\u2014C(O)\u2014O-alkyl, \u2014NH\u2014C(O)\u2014O-cycloalkyl, \u2014N(R d )\u2014C(O)-alkyl, \u2014N(R d )\u2014C(O)-aryl, \u2014N(R d )\u2014S(O 2 )cycloalkyl, \u2014S(O 2 )NH 2 , \u2014S(O 2 )NH(alkyl), \u2014S(O 2 )N(R d )cycloalkyl, \u2014S(O 2 )N(alkyl) 2 , \u2014C(O)N(H)(alkyl), \u2014C(O)N(R d )(cycloalkyl), and methylenedioxy; R p  and R p1  are independently H, halo, C 1 -C 4  alkyl, or C 3 -C 4  cycloalkyl; R a  and R a1  are independently H, halo, C 1 -C 4  alkyl, or C 3 -C 4  cycloalkyl; R b  is halo, C 1 -C 4  alkyl, C 1 -C 3  hydroxyl-alkyl, or C 3 -C 4  cycloalkyl; R c  is H, halo, C 1 -C 4  alkyl, or C 3 -C 4  cycloalkyl; R d  is H, halo, C 1 -C 4  alkyl, or C 3 -C 4  cycloalkyl; and z is 0, 1 or 2.

Metadata:
- Claim Count in Document: 147.0
- Percentile: 96.0
- Lexical Diversity: 1.16667
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15786539', '15905524', '14451600', '14774937', '14631625']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8381933396690286
- 35 USC 102 Novelty (BERT): 0.5903548153619318
- Combined Prediction Score: 0.813409487238319
- Mean Citation Score: 397.345142
- Max Citation Score: 544.4386599999998
- Similarity Product: 448.45727786322817

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test