PATENT CLAIM ANALYSIS

Application Number: 15973340
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-04
Patent Classification: ["544", "183000"]

Abstract:
Compounds and compositions useful for treating disorders related to KIT and PDGFR are described herein.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: W is selected from hydrogen and wherein Ring A is selected from monocyclic aryl, bicyclic aryl, monocyclic heteroaryl, bicyclic heteroaryl, cycloalkyl, and heterocyclyl;\n Z is selected from pyrazolyl substituted with one occurrence of R C ; \n L is selected from \u2014N(R 1 )\u2014C(O)\u2014, \u2014N(R 1 )C(O)N(R 1 )\u2014, \u2014N(R 1 )C(O)N(R 1 )\u2014(C 1 -C 6 alkylene)-, N(R 1 )\u2014(C 1 -C 6 alkylene)-, \u2014N(R 1 )\u2014C(O)\u2014(C 1 -C 6 alkylene)-, \u2014N(R 1 )\u2014S(O) 2 , and \u2014N(R 1 )\u2014S(O) 2 -(C 1 -C 6 alkylene)-, wherein each alkylene is independently substituted with 0-5 occurrences of R 2 ; \n each RA is independently selected from C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 heteroalkyl, \u2014N(R 1 )(R 1 ), cyano, and \u2014OR 1 ; \n each R B  is independently selected from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, hydroxyl, halo, C 1 -C 6 alkoxy, a haloalkyl, \u2014N(R 1 )(R 1 ), and cyano; \n R C  is selected from C 1 -C 6 alkyl, C 1 -C 6 alkynyl, halo, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, C 1 -C 6 hydroxyalkyl, cycloalkyl, monocyclic aryl, bicyclic aryl, monocyclic aryloxy, bicyclic aryloxy, monocyclic aralkyl, bicyclic aralkyl, monocyclic heterocyclyl, bicyclic heterocyclyl, monocyclic heterocyclylalkyl, bicyclic heterocyclylalkyl, nitro, cyano, \u2014C(O)R 1 , \u2014OC(O)R 1 , \u2014C(O)OR 1 , \u2014SR 1 , \u2014S(O) 2 R 1 , \u2014S(O) 2 \u2014N(R 1 )(R 1 ), \u2014(C 1 -C 6 alkylene)-S(O) 2 \u2014N(R 1 )(R 1 ), \u2014N(R 1 )(R 1 ), \u2014C(O)\u2014N(R 1 )(R 1 ), \u2014N(R 1 )(R 1 )\u2014C(O)R 1 , \u2014(C 1 -C 6 alkylene)-N(R 1 )\u2014C(O)R 1 , \u2014NR 1 S(O) 2 R 1 , \u2014P(O)(R 1 )(R 1 ), and \u2014OR 1 , wherein each of heteroalkyl, haloalkyl, haloalkoxy, alkyl, alkynyl, cycloalkyl, aryl, aryloxy, aralkyl, heterocyclyl, and heterocyclylalkyl is independently substituted with 0-5 occurrences of R a ; \n each R D  is independently selected from halo, C 1 -C 6 alkyl, C 1 -C 6 cycloalkyl, hydroxyl, halo, a alkoxy, c 1 -C 6 haloalkyl, \u2014N(R 2 )(R 2 ), and cyano; \n each R 1  is independently selected from hydrogen, hydroxyl, halo, thiol, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 thioalkyl, \u2014NR\u2033R\u2033, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl, wherein each of C 1 -C 6 alkyl, cycloalkyl, and heterocyclyl is independently substituted with 0-5 occurrences of R b ; or 2 R 1  together with the atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring; \n each R 2  is independently selected from hydroxyl, C 1 -C 6  alkyl, C 1 -C 6  alkoxyl, and - NR\u2032R\u2032; or 2 R 2  together with the atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring; \n each R a  and R b  is independently selected from hydrogen, halo, cyano, hydroxyl, C 1 -C 6  alkoxyl, \u2014C(O)R\u2032, C(O)OR\u2032, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  heteroalkyl, C 1 -C 6 hydroxyalkyl, \u2014NR\u2032R\u2032, and cycloalkyl, wherein cycloalkyl is substituted with 0-5 occurrences of R\u2032; \n each R\u2032 is independently selected from hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, C 1 -C 6 heteroalkyl, halo, hydroxyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, cycloalkyl and cyano; or 2 R\u2032 together with the atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring; \n each R\u2033 is independently selected from hydrogen, C 1 -C 6 alkyl, \u2014C(O)\u2014C 1 -C 6 alkyl, \u2014C(O)\u2014NR\u2032R\u2032, and \u2014C(S)\u2014NR\u2032R\u2032; and \n q and r are independently 0, 1, 2, 3, or 4.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 1.06667
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15217503', '14887614', '14517480', '14817931', '15355425']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8365796936172049
- 35 USC 102 Novelty (BERT): 0.582111695950209
- Combined Prediction Score: 0.8111328938505054
- Mean Citation Score: 451.7989759999999
- Max Citation Score: 506.97495
- Similarity Product: 415.43785325587385

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test