PATENT CLAIM ANALYSIS

Application Number: 16215296
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["546", "276400"]

Abstract:
The invention provides chiral haptens (−)-3′-AmNic and (−)-N4N for use in generating antibodies in a patient specific for (−)-nicotine. The haptens can be conjugated to suitable carrier proteins and administered as an antigenic mixture, optionally comprising adjuvant(s), to a patient suffering from nicotine or tobacco addiction or habituation.

Claim (Index 1):
A process for preparing a compound according to the formula (\u2212)-N4N: comprising the steps of:\n (A) contacting (\u2212)-(S)-nicotine sequentially with (i) trimethylacetyl chloride and (ii) a combination of (3-ethoxy-3-oxopropyl)zinc(II) iodide, lithium chloride, and copper cyanide to yield a compound according to formula 3: \n (B) contacting the compound according to formula 3 with sulfur to yield a compound according to formula 4: (C) contacting the compound according to formula 4 with NH 4 OH to yield a compound according to formula 5: \u2003and (D) contacting the compound according to formula 5 with sodium bis(2-methoxyethoxy)aluminum hydride to yield the compound according to formula (\u2212)-N4N.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 98.0
- Lexical Diversity: 1.42222
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12836165', '11780742', '10909841', '13151590', '15306466']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7749450467508041
- 35 USC 102 Novelty (BERT): 0.5118410793020398
- Combined Prediction Score: 0.7486346500059278
- Mean Citation Score: 246.70369800000003
- Max Citation Score: 258.7228
- Similarity Product: 152.0488629208088

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test