PATENT CLAIM ANALYSIS

Application Number: 16186451
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["536", "124000"]

Abstract:
Disclosed herein are soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.

Claim (Index 9):
A stable, sterile soft tissue filler comprising:\n a hyaluronic acid (HA) component comprising HA crosslinked with 1,4-butanediol diglycidyl ether (BDDE), and uncrosslinked HA; and lidocaine at a concentration of about 0.3% by weight of the soft tissue filler combined with the crosslinked HA component; wherein the soft tissue filler is stable after heat sterilization at between about 120\u00b0 C. and about 130\u00b0 C.; wherein the soft tissue filler has a pH of about 7; and wherein the stable, sterile soft tissue filler is made by a process comprising:\n providing the HA component crosslinked with BDDE; \n adding a solution containing lidocaine to the HA component crosslinked with BDDE to obtain a soft tissue filler; and \n heat sterilizing the soft tissue filler to obtain a stable, sterile soft tissue filler.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 98.0
- Lexical Diversity: 1.57143
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12393884', '12393768', '13891052', '16186448', '15173850']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6827043430548425
- 35 USC 102 Novelty (BERT): 0.5936724327338506
- Combined Prediction Score: 0.6738011520227434
- Mean Citation Score: 485.48709
- Max Citation Score: 515.6925
- Similarity Product: 494.6584676975013

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test