PATENT CLAIM ANALYSIS

Application Number: 16028257
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-03
Patent Classification: ["548", "515000"]

Abstract:
The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.

Claim (Index 94):
A compound of the following formula II: or a pharmaceutically acceptable salt thereof, wherein: R 1  and R 2  are independently selected from hydrogen, unsubstituted C 1-10  alkyl, C 3-10  alkenyl and C 3-10  alkynyl, and substituted C 1-10  alkyl, C 3-10  alkenyl and C 3-10  alkynyl wherein the substituent is one or more of hydroxy, cyano, halogen, C 1-6  alkoxy, aryl substituted C 1-6  alkoxy, aryloxy, aryloxy substituted with one or more halogens, C 1-6  alkyl, C 1-6  alkyl independently substituted with one or more of cyano and halogen, C 1-4  alkoxy, and C 1-4  haloalkoxy; R 3  is selected from hydrogen, C 1-6  alkoxycarbonyl, C 2-6  alkanoyl, C 3-8  cycloalkyl, C 4-9  cycloalkanoyl, aryl, heteroaryl, saturated heterocyclic, C 2-10  alkenyl, C 2-10  alkynyl, and substituted C 1-6  alkyl, C 2-10  alkenyl and C 2-10  alkynyl wherein the substituent is one or more of cyano, halogen, hydroxy, C 1-6  alkoxy, C 1-6  alkoxycarbonyl, C 2-6  alkyloxycarbonyloxy, C 1-6  alkanoyl, C 1-6  alkanoyloxy, C 3-8  cycloalkyl, C 3-8  cycloalkyloxy, C 4-9  cycloalkanoyl, aryl, aryloxy, heteroaryl and saturated heterocyclic; and R 4  and R 5  are independently hydrogen or 1-4 substituents independently selected from halogen, C 1-3  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, halo(C 1-3 )alkyl, cyano, hydroxy, C 3-5  cycloalkyl, C 1-3  alkoxy, C 1-3  alkoxy(C 1-3 )alkyl, carboxy(C 1-3 )alkyl, C 1-3  alkanoyl, halo(C 1-3 )alkoxy, nitro, amino, C 1-3  alkylamino, and di(C 1-3 )alkylamino.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 95.0
- Lexical Diversity: 1.25
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14929361', '13887367', '15648424', '14802802', '14494512']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8267619600354106
- 35 USC 102 Novelty (BERT): 0.6440169412254824
- Combined Prediction Score: 0.8084874581544178
- Mean Citation Score: 558.0055440000001
- Max Citation Score: 615.3233
- Similarity Product: 598.5583123918235

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test