PATENT CLAIM ANALYSIS

Application Number: 16003565
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "130000"]

Abstract:
Benzocyclooctene (fused 6,8 ring system) analogues and corresponding indene (fused 6,5 ring system) analogues function as inhibitors of tubulin polymerization. The compounds are useful as anticancer agents in a new therapeutic approach for cancer treatment utilizing small-molecule inhibitors of tubulin polymerization that also act as vascular disrupting agents (VDAs).

Claim (Index 1):
A method of treating a vascular proliferative disorder in a subject, comprising:\n administering a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a therapeutically effective amount of a benzocyclooctene compound demonstrating inhibition of tubulin polymerization and having a structure of: wherein A is a bond, C\u2550O, C\u2550NH, or C\u2550NR 1 , where R 1  is any alkyl, aryl, or alkaryl substituent,\n B is CH 2 , NH, O, S, CH\u2014OH, or CH\u2014OR 2 , wherein R 2  is CH 3 , or PO 3 \u2212 , or C\u2014Z, wherein Z is halogen, and \n D is CH, N, C\u2014OH, or C\u2014OR 3 , wherein R 3  is CH 3 , any alkyl substituent, any alkoxy substituent, any alkyl or alkoxy substituent including heteroatoms, any carbonyl substituent, any ester substituent, or PO 3 \u2212  or C\u2014Z, wherein Z is halogen, and \n wherein the pharmaceutical composition further comprises a pharmaceutically acceptable excipient, adjuvant, carrier, buffer, stabilizer, or mixture thereof.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 94.0
- Lexical Diversity: 1.39024
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13216927', '12981233', '13676650', '15309357', '15858183']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7521997821212266
- 35 USC 102 Novelty (BERT): 0.5092793998383472
- Combined Prediction Score: 0.7279077438929387
- Mean Citation Score: 250.81393
- Max Citation Score: 263.24713
- Similarity Product: 172.54721068376182

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test