PATENT CLAIM ANALYSIS

Application Number: 16037429
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["424", "489000"]

Abstract:
A method of designing a pharmaceutical composition for providing the liver of a person or animal, as a therapeutic target, with a predetermined concentration of a sulfate or sulfonate of a pharmacologically active agent, during a predetermined period, includes determining the correlation between the solubility of a sulfate and/or sulfonate of a pharmacologically active agent of the formula D n+ (R 1 SO 3 ) − n  or D n+ (R 2 OSO 3 ) − n  for various carbon chain lengths X, Y in an aqueous solvent and the expected concentration of the pharmaceutically active agent D in the therapeutic target upon administration of the pharmacologically active agent D to the person or animal, defining a target solubility of the sulfate or sulfonate based on a desired concentration of said pharmaceutically active substance D in the therapeutic target, and determining the carbon chain length(s) X, Y corresponding to the target solubility.

Claim (Index 1):
A method of designing a pharmaceutical composition for providing, during a predetermined period, as a therapeutic target, the liver of a person or animal, with a predetermined concentration of a sulfate or sulfonate of a pharmacologically active agent comprising from 1 to 4 amino groups represented by formula (1) or (2), or a mixture of these agents:\n D n+ (R 1 SO 3 ) \u2212 n \u2003\u2003(1) D n+ (R 2 OSO 3 ) \u2212 n \u2003\u2003(2) wherein R 1  is straight chain C 6 -C 30  alkyl; R 2  is straight chain C 6 -C 30  alkyl; n is an integer from 1 to 4; wherein the method comprises: i) determining the solubility of D n+ (R 1 SO 3 ) \u2212 n  or D n+ (R 2 OSO 3 ) \u2212 n  for various carbon chain lengths X, Y in an aqueous solvent; ii) determining the correlation between the solubility of said sulfate or sulfonate of said pharmacologically active agent and the expected concentration of said pharmaceutically active agent D in the therapeutic target upon administration of said pharmacologically active agent D to the person or animal; iii) defining a target solubility of said sulfate or sulfonate of said pharmacologically active agent in said solvent based on a desired concentration of said pharmaceutically active substance D in said therapeutic target; iv) determining the carbon chain length(s) X; Y corresponding to said target solubility; v) providing a sulfate or sulfonate of said pharmacologically active agent comprising the so determined carbon chain length(s) X, Y; vi) providing a fluid carrier; and vii) combining said sulfate or sulfonate of said pharmacologically active agent comprising the so determined carbon chain length(s) X, Y with the fluid carrier in an amount capable of maintaining said concentration during said period in said target.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 95.0
- Lexical Diversity: 2.27397
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15509875', '15300688', '12809259', '13623473', '14116182']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6951520212218198
- 35 USC 102 Novelty (BERT): 0.5864949561489456
- Combined Prediction Score: 0.6842863147145324
- Mean Citation Score: 255.280678
- Max Citation Score: 580.5892
- Similarity Product: 390.2419325852871

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test