PATENT CLAIM ANALYSIS

Application Number: 16204403
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["424", "464000"]

Abstract:
The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designated to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance within the gastrointestinal tract upon oral administration can be avoided and, thereby, enabling a reduction in gastro-intestinal related side-effects.

Claim (Index 46):
A controlled release pharmaceutical composition for oral use in the form of a capsule or a tablet comprising as an active substance one or more fumaric acid esters selected from di-(C 1 -C 5 )alkylesters of fumaric acid and mono-(C 1 -C 5 )alkylesters of fumaric acid, or a pharmaceutically acceptable salt thereof, wherein the release of the fumaric acid ester when subjected to an in vitro dissolution test employing 0.1 N hydrochloric acid as dissolution medium during the first 2 hours of the test and then 0.05 M phosphate buffer pH 6.5 as dissolution medium, wherein the dissolution profile is determined as described in the United States Pharmacopoeia at 37\u00b0 C. and a rotation speed of 100 rpm using a rotating basket for a capsule and a paddle dissolution apparatus for a tablet is as follows: within the first 3 hours after start of the test at the most 70% w/w of the total amount of the fumaric acid ester contained in the composition is released.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 98.0
- Lexical Diversity: 1.44262
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13143498', '09823202', '12529674', '12692063', '12044706']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6767640456054611
- 35 USC 102 Novelty (BERT): 0.5053710964950243
- Combined Prediction Score: 0.6596247506944174
- Mean Citation Score: 203.683708
- Max Citation Score: 281.89325
- Similarity Product: 219.5223360497952

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test