PATENT CLAIM ANALYSIS

Application Number: 15752128
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "325000"]

Abstract:
The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.

Claim (Index 1):
A conformationally stable atropisomer of a pyrrolopyrimidine-based kinase inhibitor wherein the selectivity of the atropisomer is modulated compared to the corresponding rapidly interconverting parent kinase inhibitor, wherein the pyrrolopyrimidine-based kinase inhibitor comprises an atropisomerism rotational blocking moiety on a rotatable phenyl moiety of the parent kinase inhibitor that conformationally stabilizes the atropisomer having modulated kinase selectivity.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.3
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['10716165', '11718692', '12731089', '14488296', '14488294']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6440531406189592
- 35 USC 102 Novelty (BERT): 0.5184085707540876
- Combined Prediction Score: 0.6314886836324721
- Mean Citation Score: 207.554184
- Max Citation Score: 222.47041
- Similarity Product: 131.78538762386083

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test