PATENT CLAIM ANALYSIS

Application Number: 15957686
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "001000"]

Abstract:
Disclosed herein are embodiments of a method for using estrogenic compounds to manipulate the bacterial composition of vaginal communities of female subjects. The method may include titrating a dose of an estrogenic compound to provide a female subject with a personalized effective dose, such as a minimum effective dose, sufficient to attain and/or maintain one or more determined target values of a relative abundance of vaginal  Lactobacillus  in the vaginal microbiota, an absolute abundance of vaginal  Lactobacillus  in the vaginal microbiota, a vaginal pH, a vaginal lactic acid concentration, or any combination thereof.

Claim (Index 1):
A method, comprising:\n obtaining a vaginal sample from a female subject, the vaginal sample comprising a vaginal microbiota; obtaining initial analysis results of the vaginal sample, the initial analysis results comprising a relative abundance of  Lactobacillus  in the vaginal microbiota, an absolute abundance of  Lactobacillus  in the vaginal microbiota, a vaginal pH, a vaginal lactic acid concentration, or any combination thereof; determining, based at least in part on the initial analysis results, an effective dose of an estrogenic compound for administration to the female subject to shift the relative abundance of vaginal  Lactobacillus  in the vaginal microbiota, the absolute abundance of vaginal  Lactobacillus  in the vaginal microbiota, the vaginal pH, the vaginal lactic acid concentration, or any combination thereof toward one or more determined target values; and administering one or more effective doses of the estrogenic compound to the female subject over an effective period of time, in response to which the relative abundance of vaginal  Lactobacillus  in the vaginal microbiota, the absolute abundance of vaginal  Lactobacillus  in the vaginal microbiota, the vaginal pH, the vaginal lactic acid concentration, or any combination thereof shifts toward or attains the one or more determined target values.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 91.0
- Lexical Diversity: 1.68333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15536297', '11331856', '15155675', '15740807', '14496737']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7156614094281143
- 35 USC 102 Novelty (BERT): 0.5058923632907594
- Combined Prediction Score: 0.6946845048143788
- Mean Citation Score: 232.489466
- Max Citation Score: 243.5908
- Similarity Product: 173.48279445676803

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test