PATENT CLAIM ANALYSIS

Application Number: 15873400
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["424", "489000"]

Abstract:
The present invention provides compositions, systems, and methods employing cleavable polymeric micelles. For example, provided herein are compositions comprising micelles that contain a hydrophobic agent (e.g., metal nanoparticles and/or therapeutic agent), where the micelles are formed from a plurality of amphiphilic polymer molecules that comprise a hydrophilic polymer and a hydrophobic polymer, where the hydrophobic polymer comprises a cleavable Furan-Maleimide adduct. Also provided herein are methods of administering such compositions to a subject and treating a localized area of the subject with a device that emits heat, NIR light, and/or alternating magnetic current such that at least some of the micelles inside the subject near the localized area are disrupted (e.g., releasing a therapeutic agent).

Claim (Index 1):
A method of generating Janus nanostructures comprising:\n a) combining a first aqueous solution and a second aqueous solution to generate a mixture, wherein said first aqueous solution comprises a plurality of first thermo-cleavable micelles (first TCMs), and wherein said second aqueous solution comprises a plurality of second thermo-cleavable micelles (second TCMs), wherein each of said first and second TCMs comprises a plurality of amphiphilic polymer molecules, wherein each of said amphiphilic polymer molecules comprises a hydrophilic polymer and a hydrophobic polymer, and wherein said hydrophobic polymer comprises a first region, a second region, and a cleavable Furan-Maleimide adduct which separates said first from said second regions, wherein each of said first TCMs further comprises first metal nanoparticles coated with an organic hydrophobic coating, and wherein each of said second TCMs further comprises second metal nanoparticles coated with an organic hydrophobic coating, wherein said second metal nanoparticles are different from said first metal nanoparticles; and b) exposing said mixture to heat under conditions such that said hydrophobic polymers are cleaved in said plurality of first and second TCMs, thereby causing said plurality of first and second TCMs to combine together to generate a plurality of Janus nanostructures, wherein each of said Janus nanostructures comprises some of said first and second metal nanoparticles which are arranged in an asymmetrical pattern inside said Janus nanostructures.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 86.0
- Lexical Diversity: 1.87143
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15054739', '13697149', '12416993', '15048098', '12307356']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6818690539405173
- 35 USC 102 Novelty (BERT): 0.511013575906585
- Combined Prediction Score: 0.6647835061371241
- Mean Citation Score: 255.5612
- Max Citation Score: 267.4456
- Similarity Product: 193.0552657072068

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test