PATENT CLAIM ANALYSIS

Application Number: 15906268
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "233200"]

Abstract:
The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.

Claim (Index 23):
The pharmaceutical composition according to  claim 22  comprising a compound selected from formulae Ig-1, Ig-2, Ig-3, Ig-4, Ig-5, Ig-6, Ig-7 and Ig-8 or a pharmaceutically acceptable salt or solvate thereof and at least one pharmaceutically acceptable carrier, diluent, excipient and/or adjuvant, wherein a depicts the bond linking R 1  to the piperazine moiety; and Ar 1 , R 1 , X 1  and X 2  are as defined in claim  2 ; and R 14 , R 14\u2032 , R 15 , R 34 , R 35 , X 3  X 5  and X 6  are as defined in claim  6 ; and R 12\u2032  and R 13  are independently selected from H, halo, cyano, alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, heteroalkyl, hydroxyl, alkoxy, haloalkoxy, carboxy, alkoxycarbonyl, alkylcarbonyloxy, alkylcarbonylamino, haloalkylcarbonylamino, acylamino, carbamoyl, alkylcarbamoyl, carbamoylalkyl, carbamoylamino, alkylcarbamoylamino, alkylsulfonyl, haloalkylsulfonyl, sulfamoyl, alkylsulfamoyl, alkylsulfonylamino, haloalkylsulfonylamino, or R 13  together with R 12\u2032  forms an alkylenedioxy group or a haloalkylenedioxy group, each of said groups being optionally substituted by one or more group(s) selected from halo, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyl or oxo; and R 18 , R 19 , R 19\u2032  and R 20  are independently selected from H, halo, cyano, alkyl, haloalkyl, cyclopropyl, alkoxy, haloalkoxy; and R 21 , R 21\u2032 , R 22 , R 22\u2032  and R 23  are independently selected from H, halo, cyano, alkyl, haloalkyl, cyclopropyl, heterocyclyl optionally substituted by alkyl, hydroxyl, alkoxy, haloalkoxy, hydroxyalkoxy, alkylamino, alkylsulfonylamino, aminoalkoxy, alkoxycarbonylaminoalkoxy; and R 24 , R 24\u2032 , R 25 , R 25\u2032  and R 26  are independently selected from H, halo haloalkyl, cyclopropyl; and R 27 , R 28 , R 29  and R 30  are independently selected from H, halo, cyano, alkyl, haloalkyl, cyclopropyl, alkoxy, haloalkoxy; and R 27\u2032 , R 28\u2032 , R 29\u2032  and R 30\u2032  are absent, or R 27\u2032 , R 28\u2032 , R 29\u2032  and R 30\u2032  are H under the condition that R 28 , R 29  and R 30  are H and that R 27  is selected from H, chloro or fluoro; and the two bonds represented by the dotted lines in formula Ig-4 are both absent, or both present under the condition that R 27\u2032 , R 28\u2032 , R 29\u2032  and R 30\u2032  are absent; and R 31 , R 31\u2032 , R 32 , R 32\u2032  and R 33  are independently selected from H, halo, cyano, alkyl, haloalkyl, cyclopropyl, alkoxy, haloalkoxy; and wherein,\n in formula Ig-1 when:\n R 1  is H, and \n Ar 1  is a 6-membered aryl optionally substituted by one or more group(s) selected from halo, cyano, C1-C3 alkyl, C1-haloalkyl, and \n R 12\u2032 , R 13 , R 18 , R 19 , R 19\u2032  and R 20  are independently selected from H, halo, C1-3 alkyl, hydroxyl, methoxy, \n then, \n Ar 1  is phenyl, 3-halophenyl, 4-halophenyl, 2,3-dichlorophenyl, 3,4-dihalophenyl, 3,4,5-trihalophenyl, 4-cyanophenyl, 4-(C1-C3 alkyl)phenyl, 4-(C1 haloalkyl)phenyl, and \n R 12\u2032 , R 13 , R 18 , R 19 , R 19\u2032  and R 20  are H, or R 12\u2032 , R 13 , R 19 , R 19\u2032 , R 20  are H and R 18  is fluoro, chloro, and \n \n in formula Ig-4 when\n R 1  is H, and \n Ar 1  is a 6-membered aryl optionally substituted by one or more group(s) selected from halo, cyano, C1-C3 alkyl, C1-haloalkyl, and \n R 27 , R 28 , R 29  and R 30  are independently selected from H, halo, C1-3 alkyl, methoxy, and \n R 27\u2032 , R 28\u2032 , R 29\u2032  and R 30\u2032  are absent or H under the condition that R 28 , R 29  and R 30  are H and R 27  is selected from H, chloro or fluoro, \n then \n Ar 1  is phenyl, 3-halophenyl, 4-halophenyl, 2,3-dichlorophenyl, 3,4-dihalophenyl, 3,4,5-trihalophenyl, 4-cyanophenyl, 4-(C1-C3 alkyl)phenyl, 4-(C1 haloalkyl)phenyl, and \n R 27 , R 28 , R 29  and R 30  are H, and \n R 27\u2032 , R 28\u2032 , R 29\u2032  and R 30\u2032  are absent or H under the condition that R 27 , R 28 , R 29  and R 30  are H.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 88.0
- Lexical Diversity: 1.05882
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14349595', '14799208', '13627091', '15259922', '15205304']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8160637346822771
- 35 USC 102 Novelty (BERT): 0.6162557340980243
- Combined Prediction Score: 0.7960829346238518
- Mean Citation Score: 548.391766
- Max Citation Score: 607.86743
- Similarity Product: 481.05328624700905

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test