PATENT CLAIM ANALYSIS

Application Number: 16045879
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["424", "130100"]

Abstract:
The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.

Claim (Index 44):
The method of  claim 43 , further comprising:\n (iv) selecting a compound that binds to the active conformational state of the GPCR.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 95.0
- Lexical Diversity: 2.06849
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15409285', '15236398', '13810652', '15816505', '15819500']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8319703417573628
- 35 USC 102 Novelty (BERT): 0.5952025297686699
- Combined Prediction Score: 0.8082935605584936
- Mean Citation Score: 596.230936
- Max Citation Score: 662.7651400000002
- Similarity Product: 421.2789836459769

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test