PATENT CLAIM ANALYSIS

Application Number: 16034610
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["530", "300000"]

Abstract:
The invention relates to a method for determining the presence of at least one distinct polypeptide in a biological sample comprising contacting the biological sample with a hydrolyzing agent, wherein the hydrolyzing agent is capable of hydrolyzing the distinct polypeptide in a sequence-specific manner such that at least one distinct peptide having a predetermined peptide measured accurate mass would result if the at least one distinct polypeptide were present in the biological sample, to obtain a hydrolyzed sample; bringing the hydrolyzed sample in contact with a substrate comprising at least one immobilized binding partner, wherein the at least one immobilized binding partner is capable of specifically binding the distinct peptide; removing the hydrolyzed sample from the substrate in a manner such that the distinct peptide would remain bound to the immobilized binding partner; contacting the substrate with an elution solution, wherein the distinct peptide would dissociate from the immobilized binding partner into the elution solution; subjecting a portion of the elution solution to liquid chromatography to segregate a plurality of molecules in the portion of the elution solution to obtain sorted molecules; determining the measured accurate mass of at least one sorted molecule present in the elution solution; and determining the presence of the at least one distinct polypeptide in the biological sample when a measured accurate mass of at least one molecule is substantially equal to the predetermined peptide measured accurate mass.

Claim (Index 32):
The method of  claim 30 , wherein the standard peptide comprises an isotope selected from the group consisting of  15 N,  13 C,  18 O and  2 H.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 95.0
- Lexical Diversity: 3.21053
- Patent Class: 530.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12931445', '15245393', '13856933', '13683778', '13575834']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7251734110904485
- 35 USC 102 Novelty (BERT): 0.5757248667218239
- Combined Prediction Score: 0.7102285566535861
- Mean Citation Score: 331.30275199999994
- Max Citation Score: 491.19046
- Similarity Product: 410.3146219962192

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test