PATENT CLAIM ANALYSIS

Application Number: 15972012
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-04
Patent Classification: ["424", "450000"]

Abstract:
The present invention provides liposome compositions containing sparingly soluble drugs that are used to treat life-threatening diseases. A preferred method of encapsulating a drug inside a liposome is by remote or active loading. Remote loading of a drug into liposomes containing a transmembrane electrochemical gradient is initiated by co-mixing a liposome suspension with a solution of drug, whereby the neutral form of the compound freely enters the liposome and becomes electrostatically charged thereby preventing the reverse transfer out of the liposome. There is a continuous build-up of compound within the liposome interior until the electrochemical gradient is dissipated or all the drug is encapsulated in the liposome. However, this process as described in the literature has been limited to drugs that are freely soluble in aqueous solution or solubilized as a water-soluble complex. This invention describes compositions and methods for remote loading drugs with low water solubility (<2 mg/mL). In the preferred embodiment the drug in the solubilizing agent is mixed with the liposomes in aqueous suspension so that the concentration of solubilizing agent is lowered to below its capacity to completely solubilize the drug. This results in the drug precipitating but remote loading is capability retained. The process is scalable and the resulting drug-loaded liposomes are characterized by a high drug-to-lipid ratios and predictable drug retention when the liposome encapsulated drug is administered in patients.

Claim (Index 12):
The pharmaceutical formulation according to  claim 11 , wherein said carboxylate is acetate.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 93.0
- Lexical Diversity: 1.92
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15502092', '15216416', '13709005', '11576595', '10962246']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7904237145214865
- 35 USC 102 Novelty (BERT): 0.6199407600247986
- Combined Prediction Score: 0.7733754190718177
- Mean Citation Score: 426.934994
- Max Citation Score: 642.96063
- Similarity Product: 494.42633483213433

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test