PATENT CLAIM ANALYSIS

Application Number: 15758274
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "233200"]

Abstract:
The present invention provides methods for inhibiting Fyn kinase, using 5-3-pyridin-2-amine, 6-3-imidazo[1,2-a] pyrazine, 6-3-imidazo[1,2-b] pyridazine, N-(5-imidazo [2,1-b][1,3,4] thiadiazol-2-yl)-amine, 4-3-1H-pyrazolo[3,4-b] pyridine, and N-(3-imidazo [1,2-b] pyridazin-6-yl) amine compounds and methods of treatment, prevention, inhibition or amelioration of diseases and conditions associated with Fyn kinase using such compounds.

Claim (Index 12):
A compound of formula (IV) selected from the group consisting of 3-[2-(cyclohexylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide, N,N-dimethyl-3-[2-[2-(4-sulfamoylphenyl)ethylamino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]benzamide, 3-[2-[(4-hydroxycyclohexyl)amino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide, 1-[3-[2-[(4-hydroxycyclohexyl)amino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenyl]ethanone, N-[3-[2-(2-furylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenyl]acetamide, 3-[2-(cyclopropylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide, 3-[2-(isobutylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide, 3-[2-[(4-fluorophenyl)methylamino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide, N-[3-[2-(2-thienylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenyl] acetamide, 4-[2-[[5-(1-methylpyrazol-4-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino] ethyl]benzenesulfonamide, 4-[[5-[3-(dimethylamino)phenyl] imidazo[2,1-b][1,3,4] thiadiazol-2-yl]amino]cyclohexanol, N-[3-[2-(isobutylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenyl]methanesulfonamide, 3-[2-(3-hydroxypropylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]benzamide, 4-[2-[(4-hydroxycyclohexyl)amino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol, 3-[2-(2-furylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]benzamide, 4-[2-[[5-(6-methoxy-3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino] ethyl]benzenesulfonamide, N,N-dimethyl-3-[2-(tetrahydropyran-4-ylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]benzamide, N,N-dimethyl-3-[2-(o-tolylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]benzamide, N-isobutyl-5-(5-methoxy-3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(5-methoxy-3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 3-[2-[(4-methoxyphenyl)methylamino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide, N-[2-(4-pyridyl)ethyl]-5-(3,4,5-trimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 3-[2-(benzylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide, 5-(6-methoxy-3-pyridyl)-N-(4-pyridylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 3-[2-(2-furylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide, 2-methoxy-4-[2-(tetrahydropyran-4-ylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol, 5-(5-methoxy-3-pyridyl)-N-(4-pyridylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 4-[[5-(3-chloro-4-fluoro-phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino]cyclohexanol, 4-[2-[[5-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino] ethyl]benzenesulfonamide, 5-(3,4-dimethoxyphenyl)-N-[2-(4-pyridyl)ethyl]imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 5-(4-pyridyl)-N-(4-pyridylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 5-(6-methoxy-3-pyridyl)-N-[2-(4-pyridyl)ethyl]imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 4-[2-[[5-(3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino]ethyl]benzenesulfonamide, 5-(4-morpholinophenyl)-N-(2-thienylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, [4-[2-[(4-methoxyphenyl)methylamino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenyl]methanol, 5-(4-chlorophenyl)-N-(3-pyridylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, N-[3-[2-[2-(4-pyridyl)ethylamino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenyl] acetamide, N,N-dimethyl-3-[2-[2-(4-pyridyl)ethylamino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]benzamide, 2-methoxy-4-[2-[(4-methoxyphenyl)methylamino]imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol, 5-(6-methoxy-3-pyridyl)-N-(3-pyridylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 5-(3-chloro-4-fluoro-phenyl)-N-(2-morpholinoethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 5-(4-pyridyl)-N-[2-(4-pyridyl)ethyl]imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 4-[[5-(6-methoxy-3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino]cyclohexanol, 1-[5-[2-(2-morpholinoethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-2-thienyl]ethanone, 5-(4-pyridyl)-N-(2-thienylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, N-[3-[2-(cyclohexylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenyl]methanesulfonamide, 3-[2-(isobutylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]benzamide, 3-[2-(cyclopropylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]benzamide, 4-[[5-(3-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino]cyclohexanol, 4-[[5-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino]cyclohexanol, 5-(3-pyridyl)-N-(2-thienylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 5-(3,4-dimethoxyphenyl)-N-(4-pyridylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, N-cyclohexyl-5-(3-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, N-(2-furylmethyl)-5-(3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, N-(2-furylmethyl)-5-(1-methylpyrazol-4-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 5-(5-methoxy-3-pyridyl)-N-(2-thienylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 5-(3,4-dimethoxyphenyl)-N-isobutyl-imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 1-[3-[2-(isobutylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenyl] ethanone, N-benzyl-5-(3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, N-benzyl-5-(5-methoxy-3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 5-(3-pyridyl)-N-(tetrahydropyran-4-ylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 5-(5-methoxy-3-pyridyl)-N-(tetrahydropyran-4-ylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, N-[(4-methoxyphenyl)methyl]-5-(5-methoxy-3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, N-(o-tolylmethyl)-5-(3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine, 4-[[5-(5-methoxy-3-pyridyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]amino]cyclohexanol, 3-[2-(1,3-benzodioxol-5-ylmethylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide, and 5-(3,4-dimethoxyphenyl)-N-(tetrahydropyran-4-ylmethyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.6383
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13056331', '13057325', '12598882', '13049225', '14554714']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8304919246785806
- 35 USC 102 Novelty (BERT): 0.5337517553689163
- Combined Prediction Score: 0.8008179077476142
- Mean Citation Score: 353.30427799999984
- Max Citation Score: 374.5595
- Similarity Product: 318.89179381620886

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test