PATENT CLAIM ANALYSIS

Application Number: 15878305
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["536", "017400"]

Abstract:
The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one antifungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; or (iv) (AFA) m″ -X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nonaparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.

Claim (Index 11):
The conjugate-based prodrug of  claim 1 , wherein:\n (i) the carrier is a fatty acid selected from the group consisting of Caprylic acid, Pelargonic acid, Capric acid, Undecylic acid, Lauric acid, Tridecylic acid, Myristic acid, Pentadecylic acid, Palmitic acid, Heptadecanoic acid, Stearic acid, Nonadecylic acid, Arachidic acid, Heneicosylic acid, Behenic acid, Tricosylic acid, Lignoceric acid, Pentacosylic acid, Cerotic acid, Heptacosylic acid, Montanic acid, Myristoleic acid, Palmitoleic acid, Sapienic acid, Oleic acid, Elaidic acid, Vaccenic acid, Linoleic acid, Linoelaidic acid, \u03b1-Linolenic acid, \u03b3-Linolenic acid, Arachidonic acid, Eicosapentaenoic acid, Erucic acid, Docosahexaenoic acid, cis-11-octadecenoic acid, cis-11-eicosenoic acid, undecylenic acid, cis-13-docosenoic acid, neoheptanoic acid, neononanoic acid, neodecanoic acid, isostearic acid, 10-undecaenoic acid, adapalene, undecylenic acid; palmitic acid; oleaic acid, linoleic acid, lauric acid, and any combinations thereof; (ii) the carrier is polymer selected from the group consisting of PLGA, PLA, PEG, chitosan, pullulan, polylactides, polyglycolides, polycaprolactones, copolymers of polylactic acid and polyglycolic acid, polyanhydrides, polyepsilon caprolactone, polyamides, polyurethanes, polyesteramides, polyorthoesters, polydioxanones, polyacetals, polyketals, polycarbonates, polyorthocarbonates, polydihydropyrans, polyphosphazenes, polyhydroxybutyrates, polyhydroxyvalerates, polyalkylene oxalates, polyalkylene succinates, poly(malic acid), poly(amino acids), polyvinylpyrrolidone, polyethylene glycol, polyhydroxycellulose, polymethyl methacrylate, chitin, chitosan, copolymers of polylactic acid and polyglycolic acid, poly(glycerol sebacate) (PGS), and copolymers, terpolymers, gelatin, collagen, silk, chitosan, alginate, cellulose, poly-nucleic acids, cellulose acetates (including cellulose diacetate), polyethylene, polypropylene, polybutylene, polyethylene terphthalate (PET), polyvinyl chloride, polystyrene, polyamides, nylon, polycarbonates, polysulfides, polysulfones, hydrogels (e.g., acrylics), polyacrylonitrile, polyvinylacetate, cellulose acetate butyrate, nitrocellulose, copolymers of urethane/carbonate, copolymers of styrene/maleic acid, poly(ethylenimine), Pluronic (Poloxamers 407, 188), Hyaluron, heparin, agarose, Pullulan, ethylene/vinyl alcohol copolymers (EVOH), and copolymers including one or more of the foregoing; or (iii) the carrier is selected from the group consisting of lys-his-lys-his-lys-his hexapeptide; L- or D-tyrosine; L- or D-serine; L- or D-threonine; a peptide of 2-10 amino acids; and pullulan.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 86.0
- Lexical Diversity: 2.49333
- Patent Class: 536.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14128281', '12865693', '14674928', '13574092', '15502131']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.672136639013948
- 35 USC 102 Novelty (BERT): 0.589799108425283
- Combined Prediction Score: 0.6639028859550815
- Mean Citation Score: 277.632242
- Max Citation Score: 515.3456
- Similarity Product: 465.8042225697517

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test