PATENT CLAIM ANALYSIS

Application Number: 16060389
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "085200"]

Abstract:
Pegylated interleukin-15—related molecules and the identification thereof are described. The pegylated interleukin-15 molecules exhibit properties and characteristics that make them candidates for therapeutic use. Pharmaceutical compositions and methods of use are also described herein. 1C. Mature human IL-15 Protein NWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVI   SLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFL   QSFVHIVQMFINTS

Claim (Index 23):
The PEG IL-15 molecule of  claim 22 , comprising:\n a) a Helix A, b) an A/B Inter-helix Junction, c) a Helix B, d) a B/C Inter-helix Junction, e) a Helix C, f) a C/D Inter-helix Junction and g) a Helix D; and wherein the peptide further comprises at least one amino acid substitution comprising:\n substitution of at least one amino acid residue of Helix A other than amino acid residues 2 (W), 4-12 (NVISDLKKI; SEQ ID NO:7), or 16 (I); or \n substitution of at least one amino acid residue of the A/B Inter-helix Junction other than amino acid residues 30 (D) or 31 (V); or \n substitution of at least one amino acid residue of Helix B other than amino acid residues 32 (H), 35 (C), 40 (M), 42-44 (CFL), 47 (L) or 50 (I); or \n substitution of at least one amino acid residue of the B/C Inter-helix Junction; or \n substitution of at least one amino acid residue of Helix C other than amino acid residues 59 (I), 61-66 (DTVENL; SEQ ID NO:8), or 68-70 (ILA); or \n substitution of at least one amino acid residue of the C/D Inter-helix Junction other than amino acid residues 85 (C) or 88 (C); or \n substitution of at least one amino acid residue of Helix D other than amino acid residues 99 (F), 100 (L), 103 (F), or 105-112 (HIVQMFIN; SEQ ID NO:9).

Metadata:
- Claim Count in Document: 32.0
- Percentile: 94.0
- Lexical Diversity: 1.24324
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15513820', '15751134', '15783883', '14895880', '15513825']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7176787334054813
- 35 USC 102 Novelty (BERT): 0.5480967817421363
- Combined Prediction Score: 0.7007205382391468
- Mean Citation Score: 344.504658
- Max Citation Score: 424.69275
- Similarity Product: 302.05406420324744

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test