PATENT CLAIM ANALYSIS

Application Number: 15758787
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-02
Patent Classification: ["540", "560000"]

Abstract:
The present invention provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

Claim (Index 1):
A compound of Formula (I): or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein:\n Y is of formula: \n wherein:\n R 3  hydrogen, optionally substituted alkyl, optionally substituted acyl, or a nitrogen protecting group; \n L 1  is optionally substituted alkylene; \n L 4  is unsubstituted branched alkylene or substituted alkylene; \n X 4  is halogen, \u2014OR f , \u2014SR f , or \u2014N(R f ) 2 ; \n Ring D is a carbocyclic or a heterocyclic ring, wherein the heterocyclic ring contains one heteroatom, and the heteroatom is N; \n Ring G is a bicyclic heterocyclic or bicyclic heteroaryl ring, wherein the rings share exactly two atoms; \n E is O, S, NR E , or CHR E , wherein R E  is optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; \n each occurrence of R D  is independently hydrogen, halogen, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, \u2014OR f , \u2014SR f , \u2014N(R f ) 2 , \u2014NO 2 , or \u2014CN, or two R D  attached to adjacent atoms are joined to form an optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl ring; \n z is 0, 1, or 2; and \n d is 0, 1, 2, 3, or 4; \n R A1  is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, \u2014OR f , \u2014SR f , \u2014N(R f ) 2 , \u2014NO 2 , or \u2014CN; R A2  is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, \u2014OR f , \u2014SR f , \u2014N(R f ) 2 , \u2014NO 2 , or \u2014CN; X 1  is N or CR 5 , wherein R 5  is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, \u2014OR f , \u2014SR f , \u2014N(R f ) 2 , \u2014NO 2 , or \u2014CN; R B  is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, \u2014OR f , \u2014SR f , \u2014N(R f ) 2 , \u2014NO 2 , or \u2014CN; Ring C is aryl or heteroaryl; each occurrence of R C  is independently halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, optionally substituted sulfonyl, \u2014OR f , \u2014SR f , \u2014N(R f ) 2 , \u2014NO 2 , or \u2014CN; c is 0, 1, 2, 3, or 4; n is 0, 1, 2, 3, or 4; R 2  is hydrogen, halogen, or optionally substituted alkyl; and each occurrence of R f  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, optionally substituted sulfonyl, an oxygen protecting group, or a nitrogen protecting group, or two R f  are joined to form an optionally substituted heterocyclic or optionally substituted heteroaryl ring.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 90.0
- Lexical Diversity: 2.01562
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15426708', '15114895', '15847430', '15104132', '15904143']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7409906177384562
- 35 USC 102 Novelty (BERT): 0.5646402914350798
- Combined Prediction Score: 0.7233555851081186
- Mean Citation Score: 424.973546
- Max Citation Score: 443.95645
- Similarity Product: 354.0993342335671

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test