PATENT CLAIM ANALYSIS

Application Number: 15918614
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "020300"]

Abstract:
A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Claim (Index 37):
The method of  claim 31 , wherein the composition is stable for at least 2 years when stored lyophilized at less than or equal to 25\u00b0 C.

Metadata:
- Claim Count in Document: 89.0
- Percentile: 90.0
- Lexical Diversity: 1.56977
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12855721', '14802885', '15074266', '13385642', '10334303']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8104587517843735
- 35 USC 102 Novelty (BERT): 0.5741339543289514
- Combined Prediction Score: 0.7868262720388314
- Mean Citation Score: 458.111156
- Max Citation Score: 465.95035
- Similarity Product: 377.9118076259703

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test