PATENT CLAIM ANALYSIS

Application Number: 16029299
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["424", "093710"]

Abstract:
The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.

Claim (Index 16):
A system capable of inducing death of a target cell, comprising:\n (a) a chimeric transmembrane receptor polypeptide comprising a ligand binding domain, an immune cell signaling domain, and a gene modulating polypeptide (GMP), the GMP comprising an actuator moiety linked to a cleavage recognition site; and (b) a chimeric adaptor polypeptide comprising a receptor binding moiety linked to a cleavage moiety capable of cleaving the cleavage recognition site when in proximity to the cleavage recognition site,\n wherein upon ligand binding to the ligand binding domain, the immune cell signaling domain activates cytotoxicity of a lymphocyte and the adaptor polypeptide binds the receptor polypeptide to effect release of the actuator moiety by cleavage of the cleavage recognition site by the cleavage moiety, the released actuator moiety exhibiting the ability to modulate expression and/or activity of an immune regulatory protein within the lymphocyte.

Metadata:
- Claim Count in Document: 40.0
- Percentile: 95.0
- Lexical Diversity: 1.56667
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15806756', '15403058', '15583658', '15096971', '15543220']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7340563361490899
- 35 USC 102 Novelty (BERT): 0.5841253507303563
- Combined Prediction Score: 0.7190632376072167
- Mean Citation Score: 400.062444
- Max Citation Score: 511.30402
- Similarity Product: 396.0503182576204

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test