PATENT CLAIM ANALYSIS

Application Number: 16059821
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["800", "018000"]

Abstract:
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

Claim (Index 32):
The method of  claim 28 , wherein the one or more human V L  gene segments are selected from the group consisting of V\u03ba1-5, V\u03ba1-6, V\u03ba1-8, V\u03ba1-9, V\u03ba1-12, V\u03ba1-16, V\u03ba1-17, V\u03ba1-27, V\u03ba1-33, V\u03ba1-37, V\u03ba1-39, V\u03ba2-24, V\u03ba2-28, V\u03ba2-29, V\u03ba2-30, V\u03ba2-40, V\u03ba3-11, V\u03ba3-15, V\u03ba3-20, V\u03ba4-1, V\u03ba6-21, and a combination thereof.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 96.0
- Lexical Diversity: 2.0
- Patent Class: 800.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16059871', '16059884', '14192051', '14600829', '14682859']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.803797769981585
- 35 USC 102 Novelty (BERT): 0.7079412321820578
- Combined Prediction Score: 0.7942121162016323
- Mean Citation Score: 853.0736539999997
- Max Citation Score: 879.0234
- Similarity Product: 753.3622385522605

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test