PATENT CLAIM ANALYSIS

Application Number: 15905672
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["544", "263000"]

Abstract:
The invention provides a chemical entity of Formula (I): wherein R 1 , R 2 , X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.

Claim (Index 1):
A compound of Formula (I): or pharmaceutically acceptable salt thereof,\n wherein \n X is \u2014CH 2 \u2014 or \u2014O\u2014; \n Y is \u2014CH 2 \u2014 or \u2014CF 2 \u2014; \n Z is \u2014CH 2 \u2014 or \u2014C(\u2550O)\u2014; \n R 1  is a phenyl substituted with one, two, three, four, or five R a  members; \n each R a  is independently selected from the group consisting of: -halo, \u2014C 1-6 alkyl, \u2014C 1-6 haloalkyl, \u2014C 1-6 alkoxy, \u2014C 1-6 haloalkoxy, \u2014CN, \u2014N(C 1-6 alkyl) 2 , \u2014SF 5 , \u2014C 3-6 cycloalkyl, -pyrrolidine, -morpholine, -piperidine, -pyrazole, -furan, -imidazole, -thiophene, -thiazole, -pyridine, and -phenyl, wherein phenyl is unsubstituted or substituted with one, two, three, four, or five R b  members, or optionally two adjacent R a  members come together to form a ring, optionally unsubstituted or substituted with one or more members independently selected from: -halo, \u2014C 1-6 alkyl, or \u2014C 1-6 alkoxy; \n each R b  is independently selected from the group consisting of: \u2014Cl and \u2014F; and; \n R 2  is \u2014C 1-6 alkyl.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 88.0
- Lexical Diversity: 1.67045
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15306069', '15524586', '14408927', '14408942', '14204934']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8188775668680309
- 35 USC 102 Novelty (BERT): 0.6043083173802517
- Combined Prediction Score: 0.7974206419192531
- Mean Citation Score: 423.716522
- Max Citation Score: 546.56396
- Similarity Product: 477.0895610708141

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test