PATENT CLAIM ANALYSIS

Application Number: 16169812
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["549", "054000"]

Abstract:
This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.

Claim (Index 1):
A method of treating an estrogen-related disorder in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound of Formula: or a pharmaceutically acceptable salt thereof; wherein:\n m is 0, 1, 2, 3, or 4; \n n is 0, 1, 2, 3, or 4; \n X A  is \u2014O\u2014; \n Ring B is phenyl, naphthyl, quinolinyl, 5- or 6-membered monocyclic heteroaryl, or 7-, 8-, 9- or 10 membered bicyclic heterocyclyl; \n Ring C is phenyl, thiophenyl, 5- or 6-membered monocyclic heteroaryl, or 7-, 8-, 9-, or 10-membered bicyclic heterocyclyl; \n R 1  is selected from hydroxyl, hydrogen, halogen, \u2014O(C 1 -C 6  alkyl), \u2014OC(O)(C 1 -C 6  alkyl), \u2014OC(O)C 6 H 5 , \u2014OC(O)O(C 1 -C 6  alkyl), \u2014OC(O)OC 6 H 5 , and \u2014OSO 2 (C 2 -C 6  alkyl); \n R 2  is selected from \u2014CH\u2550CHCOOH, \u2014NH(CO)COOH, \u2014COOH, C 2 -C 6 alkenylene-COOH, and C 2 -C 6 alkynylene-COOH; \n R 3  is independently selected at each occurrence from hydrogen, halogen, \u2014CN, \u2014NO 2 , C 1 -C 6 alkyl, and C 1 -C 6 fluoroalkyl; and \n R 4  is independently selected at each occurrence from hydrogen, halogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, \u2014CN, \u2014O(C 1 -C 6  alkyl), and \u2014O(C 1 -C 6 fluoroalkyl).

Metadata:
- Claim Count in Document: 71.0
- Percentile: 97.0
- Lexical Diversity: 1.05882
- Patent Class: 549.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15374966', '15764988', '15893295', '15531245', '13717326']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7311729268520091
- 35 USC 102 Novelty (BERT): 0.6167738688224583
- Combined Prediction Score: 0.719733021049054
- Mean Citation Score: 427.842858
- Max Citation Score: 626.9444599999998
- Similarity Product: 471.3308664382373

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test