PATENT CLAIM ANALYSIS

Application Number: 15878295
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["514", "019300"]

Abstract:
Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cell. The therapeutic component may be subsequently released within an endocytic vesicle of the target cell. Nanoparticle-based drug delivery systems as described herein may provide improved efficacy and/or reduced toxicity.

Claim (Index 1):
A nanoparticle comprising:\n a hydrophobic interior portion surrounded by an outer portion, the outer portion comprising a water-soluble polymer; a therapeutic agent coupled to, and disposed at least partially within, the outer portion; and a targeting agent coupled to, and disposed at least partially within, the outer portion wherein the targeting agent is a low-affinity, high-specificity peptide ligand of a conjugate of Formula I: wherein\n 140  is a targeting agent configured to bind to a receptor of a target cell; \n 112  comprises a polyethylene glycol moiety; and \n 124  comprises a lipid having a polar moiety ( 110 ) and a non-polar moiety ( 108 ); \n or a salt thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 86.0
- Lexical Diversity: 1.80328
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14356121', '15413267', '14765620', '15301020', '12573591']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.696650592895232
- 35 USC 102 Novelty (BERT): 0.5456871279781446
- Combined Prediction Score: 0.6815542464035234
- Mean Citation Score: 256.094844
- Max Citation Score: 401.60403
- Similarity Product: 316.2246438804532

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test