PATENT CLAIM ANALYSIS

Application Number: 16224438
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["514", "001100"]

Abstract:
The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X 1 -Ala-X 2 -X 3 -Ile-Glu-X 4  (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.

Claim (Index 23):
A method for treating a disease associated with PLB, comprising administering to a subject in need thereof,\n (a) a pharmaceutically effective amount of the decoy peptide or polypeptide of consisting of a peptide sequence represented by the following Formula I:\n X 1 -Ala-X 2 -X 3 -Ile-Glu-X 4  \u2003\u2003(I) \n wherein X 1  represents 0-1 amino acid residue(s), X 2  represents Ser, Glu, or Asp, X 3  represents Thr, Glu, or Asp and X 4  represents 0-3 amino acid residue(s), with the proviso that X 2  is not Ser when X 3  is Thr; wherein the decoy peptide or polypeptide inhibits protein phosphatase 1 (PP1)-mediated dephosphorylation of phospholamban (PLB) by a competitive inhibition, wherein neither X 1  nor X 4  comprise membrane-spanning domains and X 1  is not Tyr, and wherein the decoy peptide or polypeptide is linked to a cell membrane-permeable peptide; and (b) a pharmaceutically acceptable carrier.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 98.0
- Lexical Diversity: 1.48485
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14413005', '14800657', '12598137', '09155558', '10982891']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7391458755565808
- 35 USC 102 Novelty (BERT): 0.5757865699734598
- Combined Prediction Score: 0.7228099449982688
- Mean Citation Score: 265.29647
- Max Citation Score: 473.3988
- Similarity Product: 411.5110206901073

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test