PATENT CLAIM ANALYSIS

Application Number: 15771043
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-02
Patent Classification: ["514", "021300"]

Abstract:
The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

Claim (Index 10):
The chemically modified polypeptide of  claim 1 , wherein in (i) the alkyl, cycloalkyl, alkenyl or alkynyl group is independently substituted with at least one independently selected from the group consisting of C 1 -C 16  alkyl, C 3 -C 16  cycloalkyl, C 2 -C 16  alkenyl, C 2 -C 16  alkynyl, heteroaryl, heterocyclyl, C 1 -C 6  alkoxy, azido, diaziryl \u2014CHO, 1,3-dioxol-2-yl, halo, haloalkyl, haloalkoxy, cyano, nitro, triflyl, mesyl, tosyl, heterocyclyl, aryl, heteroaryl, \u2014SR, \u2014S(\u2550O)(C 1 -C 6  alkyl), \u2014S(\u2550O) 2 (C 1 -C 6  alkyl), \u2014S(\u2550O) 2 NRR, \u2014C(\u2550O)R, \u2014OC(\u2550O)R, \u2014C(\u2550O)OR, \u2014OC(\u2550O)O(C 1 -C 6  alkyl), \u2014NRR, \u2014C(\u2550O)NRR, \u2014N(R)C(\u2550O)R, \u2014C(\u2550NR)NRR, and \u2014P(\u2550O)(OR) 2 , wherein each occurrence of R is independently H or C 1 -C 16  alkyl.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 91.0
- Lexical Diversity: 1.59524
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12845455', '13130962', '14182706', '13697021', '12066324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7949718397109945
- 35 USC 102 Novelty (BERT): 0.4982235464506144
- Combined Prediction Score: 0.7652970103849566
- Mean Citation Score: 258.376928
- Max Citation Score: 264.86304
- Similarity Product: 207.92363451553345

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test