PATENT CLAIM ANALYSIS

Application Number: 15742459
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-09
Patent Classification: ["424", "200100"]

Abstract:
Disclosed is the attenuated  Salmonella typhi  vaccine Ty21a utilized as a vector for  Shigella  and/or enterotoxogenic  E. coli  genes stably integrated in the Ty21a chromosome. These genes include a heterologous  Shigella sonnei  O-antigen biosynthetic gene region that comprises the wzz gene and expresses  Shigella sonnei  form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.

Claim (Index 6):
The transgenic Ty21a of  claim 5 , additionally comprising an O-antigen biosynthetic gene region from a bacterial strain selected from the group consisting of:  Shigella dysenteriae, Shigella flexneri, Shigella boydii, Escherichia coli, Salmonela enterica serovars, Vibrio cholera  serotypes,  Enterobacter  species,  Yersinia  species, and  Pseudomonas  species.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 86.0
- Lexical Diversity: 1.54386
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14428870', '10346706', '14660498', '13686299', '13295811']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7559844119686533
- 35 USC 102 Novelty (BERT): 0.6049195904909457
- Combined Prediction Score: 0.7408779298208825
- Mean Citation Score: 466.43767
- Max Citation Score: 575.4499
- Similarity Product: 450.56677166668175

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test