PATENT CLAIM ANALYSIS

Application Number: 15978692
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "186100"]

Abstract:
The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

Claim (Index 37):
The method of  claim 33 , wherein a high titer selected human plasma donor is identified via characterizing the specific titer of antibodies to respiratory syncytial virus in a plasma sample from the human plasma donor comprising:\n 1) conducting a first plasma screening assay to assess neutralizing activity in the plasma sample; 2) conducting a second screening assay characterizing the specific antibody titer in a purified immunoglobulin fraction from any plasma sample identified as displaying the top 20% of neutralizing activity of all plasma donor samples assayed using the first plasma screening assay; and 3) identifying a human plasma donor as a high titer selected human plasma donor when the purified immunoglobulin fraction displays an RSV neutralization titer of 1800 or above in the second screening assay.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 93.0
- Lexical Diversity: 1.82
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14592727', '14790872', '15811486', '14592721', '15460147']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8615485575080862
- 35 USC 102 Novelty (BERT): 0.7242703607020372
- Combined Prediction Score: 0.8478207378274814
- Mean Citation Score: 677.0751379999998
- Max Citation Score: 774.59973
- Similarity Product: 643.2831964784218

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test