PATENT CLAIM ANALYSIS

Application Number: 15978692
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "186100"]

Abstract:
The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

Claim (Index 33):
A method of obtaining a pooled plasma composition comprising plasma samples obtained from 1000 or more human plasma donors, wherein the pooled plasma composition comprises an RSV specific antibody titer that is at least 2 times greater than the RSV specific antibody titer in a control sample, and an antibody titer for one or more respiratory pathogens selected from parainfluenza virus 1, parainfluenza virus 2, coronavirus OC43, coronavirus 229E, influenza A virus, influenza B virus, and metapneumovirus that is at least 1.5 times greater than the antibody titer in the control sample, wherein the control sample is a mixture of plasma samples obtained from 1000 or more random human subjects, comprising\n A) obtaining plasma samples from selected human plasma donors and non-selected human plasma donors, wherein the selected human plasma donors comprise high titer selected human plasma donors and non-high titer selected human plasma donors; and B) pooling 1000 or more plasma samples from high titer selected human plasma donors, non-high titer selected human plasma donors, and non-selected human plasma donors in order to generate the pooled plasma composition.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 93.0
- Lexical Diversity: 1.82
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14592727', '14790872', '15811486', '14592721', '15460147']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8570353457244001
- 35 USC 102 Novelty (BERT): 0.744713722741927
- Combined Prediction Score: 0.8458031834261528
- Mean Citation Score: 677.0751379999998
- Max Citation Score: 774.59973
- Similarity Product: 708.1968376442708

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test