PATENT CLAIM ANALYSIS

Application Number: 15864499
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "264000"]

Abstract:
The present invention relates to compounds of formula I wherein R 1 , R 4 , Ar, W, X and Z are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps1 kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Claim (Index 30):
The method according to  claim 18 , wherein R 6  is a group of the formula:\n -L 1 -L 2 -R 17  wherein L 1  is absent or a linker group of the formula \u2014[CR 18 R 19 ] n \u2014 in which n is an integer selected from 1 or 2, and R 18  and R 19  are both hydrogen;\n L 2  is absent or is selected from O, S, SO, SO 2 , N(R 20 ), C(O), C(O)O, OC(O), CH(OR 20 ), C(O)N(R 20 ), N(R 20 )C(O), N(R 20 )C(O)N(R 21 ), S(O) 2 N(R 20 ), or N(R 20 )SO 2 , wherein R 20  and R 21  are each independently selected from hydrogen or (1-2C)alkyl; and \n R 17  is (1-6C)alkyl, aryl, (3-6C)cycloalkyl, 5 or 6 membered heteroaryl, or 3 to 8membered heterocyclyl, \n and wherein R 17  is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, hydroxy, NR 22 R 23 , (1-4C)alkoxy, (1-4C)alkyl, (1-5C)alkylsulphonyl, 3 to 6 membered heterocyclyl, 3 to 6 membered heterocyclyl-(1-2C)alkyl, 5 or 6 membered heteroaryl, 5 or 6 membered heteroaryl-(1-2C)alkyl, CONR 22 R 23 , and SO 2 NR 22 R 23 ; wherein R 22  and R 23  are each independently selected from hydrogen, (1-4C)alkyl or (3-6C)cycloalkyl or (3-6C)cycloalkyl(1-2C)alkyl; or R 22  and R 23  can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-6 membered heterocyclic ring; \n and wherein when said substituent group comprises an alkyl, cycloalkyl, heterocyclyl or heteroaryl moiety then said moiety is optionally further substituted by hydroxy, fluoro, chloro, cyano, CF 3 , OCF 3 , (1-2C)alkyl, (1-2C)alkoxy, SO 2 (1-2C)alkyl or NR e R f  (where R e  and R f  are each independently selected from hydrogen or (1-2C)alkyl). \n or R 17  is a group having the formula:\n -L 3 -L 4 -R 24  \n \n L 3  is absent or a linker group of the formula \u2014[CR 25 R 26 ]n\u2014 in which n is an integer selected from 1, 2, 3 or 4, and R 25  and R 26  are each independently selected from hydrogen or (1-2C)alkyl; L 4  is absent or is selected from O, S, SO, SO 2 , N(R 27 ), C(O), C(O)O, OC(O), CH(OR 27 ), C(O)N(R 27 ), N(R 27 )C(O), N(R 27 )C(O)N(R 28 ), S(O) 2 N(R 27 ), or N(R 28 )SO 2 , wherein R 27  and R 28  are each independently selected from hydrogen or (1-2C)alkyl; and R 24  is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl, heterocyclyl-(1-4C)alkyl.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 86.0
- Lexical Diversity: 1.69118
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15091887', '15121432', '15069012', '14426574', '15091980']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8136153760147605
- 35 USC 102 Novelty (BERT): 0.631284204650894
- Combined Prediction Score: 0.7953822588783739
- Mean Citation Score: 495.849256
- Max Citation Score: 593.34357
- Similarity Product: 531.0523509559981

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test