PATENT CLAIM ANALYSIS

Application Number: 15772919
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "394000"]

Abstract:
The present invention relates to a novel family of covalent kinases inhibitors. Compounds of this class have been found to have inhibitory activity against members of the Tec kinase family, particularly ITK, BTK, BMX, Tec and/or RLK. The present invention is directed to a compound of Formula I or pharmaceutically acceptable salt, solvate, solvate of salt, stereoisomer, tautomer, isotope, prodrug, complex or biologically active metabolite thereof and its use in therapy.

Claim (Index 1):
A compound of Formula I: or pharmaceutically acceptable salt, stereoisomer, tautomer, isotope, prodrug, complex or biologically active metabolite thereof, wherein R is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L is wherein ring B 1  is substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or wherein ring B 2  is substituted or unsubstituted polycyclic ring system; R 1  is hydrogen, lower alkyl or lower cycloalkyl; and n is an integer from 0 to 1; E is: wherein Ra, Rb and Rc are independently hydrogen, halogen, \u2014CN, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocyclyl; or Ra and Rb taken together with the carbon atoms to which they are attached form a 3- to 8-membered substituted or unsubstituted cycloalkyl ring or form a 3- to 8-membered substituted or unsubstituted heterocyclic ring and Rc is selected as above; or Rb and Rc taken together with the carbon atom to which they are attached form a 3- to 8-membered substituted or unsubstituted cycloalkyl ring or form a 3- to 8-substituted or unsubstituted membered heterocyclyc ring and Ra is selected as above; or Ra and Rb taken together with the carbon atoms to which they are attached form a triple bond and Rc is selected as above; wherein L-E is: X is selected from the group consisting of: alkylene, -(alkylene)-NR 2 \u2014,-(alkylene)-NR 3 \u2014, -(alkylene)-O\u2014, \u2014O\u2014, \u2014S\u2014, \u2014S(O) m \u2014, \u2014NR 2 \u2014, \u2014NR 3 \u2014, \u2014C(O)\u2014, \u2014C(O)O\u2014, \u2014C(O)NR 2 \u2014, \u2014C(O)ONR 2 \u2014, and \u2014S(O) m NR 2 \u2014, wherein\n R 2  is hydrogen, lower alkyl or lower cycloalkyl; \n R 3  is \u2014C(O)R 4 , \u2014C(O)OR 4  or \u2014S(O) m R 4 ; \n R 4  is lower alkyl or lower cycloalkyl; \n m is an integer from 1 to 2; or \n X is a bond; and \n Y is selected from the group consisting of: hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted heteroaralkyl.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 93.0
- Lexical Diversity: 1.49123
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15262193', '14404497', '14412982', '15037923', '14009635']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8345902813172589
- 35 USC 102 Novelty (BERT): 0.5307532378455856
- Combined Prediction Score: 0.8042065769700916
- Mean Citation Score: 352.284728
- Max Citation Score: 364.62503
- Similarity Product: 260.4690154220414

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test