PATENT CLAIM ANALYSIS

Application Number: 15953494
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "235800"]

Abstract:
Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Claim (Index 21):
A compound of Formula Ic, or a pharmaceutically acceptable salt, solvate, stereoisomer, tautomer, or prodrug thereof, wherein: X is NH or S; Y is O or S; Z is O, S, CHR 1a  or NR 1a ;\n R 11  is hydrogen, C 1-6 alkyl, or C 1-6 alkyl selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or azido groups; \n G is N or C;\n if G is N, R 1  is hydrogen C 1-6 alkyl, or C 1-6 alkyl selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or azido groups, or R 1 \u2014R 1a  is connected as a \u2014CH 2 CH 2 \u2014, \u2014CH 2 CH 2 CH 2 \u2014, \u2014CH\u2550CH\u2014, \u2014C(CH 3 )\u2550CH\u2014 or \u2014CH\u2550C(CH 3 )\u2014 group; and if G is C, R 1 \u2014R 1a  is connected as a \u2550CH\u2014CH\u2550CH\u2014, \u2550N\u2014CH\u2550CH\u2014, or \u2550CH\u2014N\u2550CH\u2014 group; \n W is OR 10a  or NHR 10a ;\n wherein R 10a  is hydrogen, C 1-6 alkyl, C 1-6 alkyl selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6  alkoxy, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or azido groups, or R 10a \u2014R 6  is connected as a \u2014CH 2 \u2014CH 2 \u2014, \u2014CH\u2550CH\u2014, \u2014N\u2550CH\u2014, or \u2014CH\u2550N\u2014 group; \n R 2  is hydrogen, halo, C 1-6 alkyl, or C 1-6 alkyl selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, or azido groups; R 3  and R 6  are independently hydrogen, halogen, \u2014SR 3a , \u2014S(O)R 3a , \u2014OR 3a , \u2014OCH 2 R 3b , \u2014OCH(CH 3 )R 3b , \u2014OC(O)NHR 3a , \u2014NR 3a R 4a , \u2014NHSO 2 R 3a , azido, \u2014CHO, CO 2 R 3a , cyano, C 1-6 alkyl or \u2014CR 5a R 6a R 7a , C 2-6 alkeny, \u2014C(R 5a )\u2550C(R 8a )(R 9a ), C 2-6 alkynyl, \u2014C\u2261CR 8a , or R 2 \u2014R 3  are connected as a \u2014CH 2 CH 2 \u2014 or \u2014CH 2 CH 2 CH 2 \u2014 group;\n R 3a , R 3b , and R 4a  are independently hydrogen, phenyl, naphthyl, pyridyl, pyrimidinyl, imidazolyl, 1,2,3-triazolyl, quinolinyl, isoquinolinyl, thiazolyl, tetrazolyl groups, C 1-6 alkyl, cyclic \u2014(C 1-8 alkyl)-, cyclic \u2014(C 1-6 oxaalkyl)-, cyclic \u2014(C 1-6 azaalkyl)-, C 2-6 alkenyl, C 2-6 alkynyl;\n wherein the phenyl, naphthyl, pyridyl, pyrimidinyl, imidazolyl, 1,2,3-triazolyl, quinolinyl, isoquinolinyl, thiazolyl, or tetrazolyl groups are optionally substituted with 1-3 substituents independently selected from the group consisting of halogen, thiol, C 1-6 alkyl thioether, C 1-6 alkyl sulfoxide, C 1-6 alkyl, C 1-6 alkoxyl, amino, C 1-6 alkylamino, C 1-6 dialkylamino, C 1-6 alkyl sulfonamide, azido, \u2014CHO, \u2014CO 2 H, C 1-6 alkyl carboxylate, cyano, C 2-6 alkeny, and C 2-6 alkynyl group; and the C 1-6 alkyl, cyclic \u2014(C 1-8 alkyl)-, cyclic \u2014(C 1-6 oxaalkyl)-, cyclic \u2014(C 1-6 azaalkyl)-, C 2-6 alkenyl, or C 2-6 alkynyl groups are selectively functionalized with one or more halogen, thiol, hydroxyl, carbonyl, carboxyl, carbonyloxyl, C 1-6 alkoxy, C 1-6 hydroxyalkoxy, amino, C 1-6 alkylamino, di(C 1-6 alkyl)amino, azido, piperidinyl, phenyl, naphthyl, pyridyl, pyrimidinyl, imidazolyl, 1,2,3-triazolyl, quinolinyl, isoquinolinyl, thiazolyl, or tetrazolyl groups; \n \n R 4  is hydrogen or halogen.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 91.0
- Lexical Diversity: 1.33333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15953492', '12096432', '14343410', '12312749', '15522969']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7895777249917006
- 35 USC 102 Novelty (BERT): 0.5603959144887585
- Combined Prediction Score: 0.7666595439414065
- Mean Citation Score: 329.689702
- Max Citation Score: 430.0401
- Similarity Product: 343.5373800496638

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test