PATENT CLAIM ANALYSIS

Application Number: 15865378
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["424", "009340"]

Abstract:
Provided are novel human α-synuclein-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for α-synuclein are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for α-synuclein targeted immunotherapy and diagnosis, respectively.

Claim (Index 42):
An antibody or antigen-binding fragment thereof that binds to human alpha-synuclein and comprises:\n an immunoglobulin heavy chain comprising a heavy chain variable region (VH) comprising VH complementarity determining regions (CDRs) 1, 2, and 3 with the amino acid sequences set forth in residues 31-35 of SEQ ID NO:9, residues 50-68 of SEQ ID NO:9, and residues 101-102 of SEQ ID NO:9, respectively; and an immunoglobulin light chain comprising a light chain variable region (VL) comprising VL CDRs 1, 2, and 3 with the amino acid sequences set forth in residues 23-33 of SEQ ID NO:12, residues 49-55 of SEQ ID NO:12, and residues 88-98 of SEQ ID NO:12, respectively, wherein the antibody or antigen-binding fragment thereof comprises a detectable label selected from the group consisting of an enzyme, a radioisotope, a fluorescent compound, a chemiluminescent compound, a bioluminescent compound, and a heavy metal.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 86.0
- Lexical Diversity: 1.59574
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13140699', '15005948', '15410128', '14128497', '14654176']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8295163843959034
- 35 USC 102 Novelty (BERT): 0.6473695344161734
- Combined Prediction Score: 0.8113016993979304
- Mean Citation Score: 618.1686000000002
- Max Citation Score: 696.7445
- Similarity Product: 579.7450916976927

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test