PATENT CLAIM ANALYSIS

Application Number: 15747571
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting a xanthine dehydrogenase (XDH) gene, and methods of using such double stranded RNAi agents to inhibit expression of an XDH gene and methods of treating subjects having an XDH-associated disease.

Claim (Index 76):
A double stranded ribonucleic acid (dsRNA) agent for inhibiting the expression of a xanthine dehydrogenase (XDH) gene in a cell, wherein said dsRNA agent comprises a sense strand complementary to an antisense strand, wherein said antisense strand comprises a region complementary to part of an mRNA encoding XDH, wherein each strand is about 14 to about 30 nucleotides in length, wherein said dsRNA agent is represented by formula (III):\n sense: 5\u2032n p -N a -(XXX) i -N b -YYY-N b -(ZZZ) j -N a -n q 3\u2032 antisense: 3\u2032n p \u2032-N a \u2032-(X\u2032X\u2032X\u2032) k -N b \u2032-Y\u2032Y\u2032Y\u2032-N b \u2032-(Z\u2032Z\u2032Z\u2032) i -N a \u2032-n q \u20325\u2032\u2003\u2003(III) wherein: i, j, k, and 1 are each independently 0 or 1; each n p , n q , and n q \u2032, each of which may or may not be present, independently represents an overhang nucleotide; p, q, and q\u2032 are each independently 0-6; n p \u2032>0 and at least one n p \u2032 is linked to a neighboring nucleotide via a phosphorothioate linkage; each N a  and N a \u2032 independently represents an oligonucleotide sequence comprising 0-25 nucleotides which are either modified or unmodified or combinations thereof, each sequence comprising at least two differently modified nucleotides; each N b  and N b \u2032 independently represents an oligonucleotide sequence comprising 0-10 nucleotides which are either modified or unmodified or combinations thereof; XXX, YYY, ZZZ, X\u2032X\u2032X\u2032, Y\u2032Y\u2032Y\u2032, and Z\u2032Z\u2032Z\u2032 each independently represent one motif of three identical modifications on three consecutive nucleotides, and wherein the modifications are 2\u2032-O-methyl or 2\u2032-fluoro modifications; modifications on N b  differ from the modification on Y and modifications on N b \u2032 differ from the modification on Y\u2032; wherein the sense strand comprises at least one phosphorothioate linkage; and wherein the sense strand is conjugated to at least one ligand, wherein the ligand is one or more GalNAc derivatives attached through a bivalent or trivalent branched linker.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 86.0
- Lexical Diversity: 1.51515
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14976261', '15670132', '14947025', '15399820', '14650128']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7838236019712547
- 35 USC 102 Novelty (BERT): 0.5513875148180497
- Combined Prediction Score: 0.7605799932559343
- Mean Citation Score: 382.727662
- Max Citation Score: 405.0581
- Similarity Product: 338.97272106449014

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test