PATENT CLAIM ANALYSIS

Application Number: 15996162
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-04
Patent Classification: ["514", "275000"]

Abstract:
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Claim (Index 68):
A method for treating a disorder selected from a BTK-mediated disorder, a TEC-kinase-mediated disorder, an ErbB1-, ErbB2-, ErbB3-, or ErbB4-mediated disorder or a JAK3-mediated disorder in a patient in need thereof, comprising the step of administering to said patient a compound of formula I-b: or a pharmaceutically acceptable salt thereof, wherein: Ring A is phenyl; Ring B is phenyl; R 1  is a warhead group -L-Y, wherein R 1  is in a meta- or para-position of the phenyl ring relative to the rest of the molecule; -L-Y is selected from \u2003or\n L is a bivalent C 2-8  straight or branched, hydrocarbon chain wherein L has at least one double bond and one or two methylene units of L are optionally and independently replaced by \u2014NRC(O)\u2014, \u2014C(O)NR\u2014, \u2014N(R)SO 2 \u2014, \u2014SO 2 N(R)\u2014, \u2014S\u2014, \u2014S(O)\u2014, \u2014SO 2 \u2014, \u2014OC(O)\u2014, \u2014C(O)O\u2014, cyclopropylene, \u2014O\u2014, \u2014N(R)\u2014, or \u2014C(O)\u2014; and Y is C 1-6  aliphatic optionally substituted with oxo, halogen, NO 2 , or CN, or a 3-10 membered monocyclic or bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein said ring is substituted with 1-4 R e  groups; or \n L is a bivalent C 2-8  straight or branched, hydrocarbon chain wherein L has at least one double bond and one methylene unit of L is replaced by \u2014C(O)\u2014, \u2014NRC(O)\u2014, \u2014C(O)NR\u2014, \u2014SO 2 N(R)\u2014, \u2014S\u2014, \u2014S(O)\u2014, \u2014SO 2 \u2014, \u2014OC(O)\u2014, or \u2014C(O)O\u2014; or \n L is a bivalent C 2-8  straight or branched, hydrocarbon chain wherein L has at least one double bond and one methylene unit of L is replaced by \u2014C(O)\u2014, and one additional methylene unit of L is optionally replaced by cyclopropylene, \u2014O\u2014, \u2014N(R)\u2014, or \u2014C(O)\u2014; or \n L is a bivalent C 2-8  straight or branched, hydrocarbon chain wherein L has at least one alkylidenyl double bond and at least one methylene unit of L is replaced by \u2014C(O)\u2014, \u2014NRC(O)\u2014, \u2014C(O)NR\u2014, \u2014N(R)SO 2 \u2014, \u2014SO 2 N(R)\u2014, \u2014S\u2014, \u2014S(O)\u2014, \u2014SO 2 \u2014, \u2014OC(O)\u2014, or \u2014C(O)O\u2014, and one or two additional methylene units of L are optionally and independently replaced by cyclopropylene, \u2014O\u2014, \u2014N(R)\u2014, or \u2014C(O)\u2014; or \n L is \u2014NRC(O)CH\u2550CHCH 2 N(CH 3 )\u2014, \u2014NRC(O)CH\u2550CHCH 2 O\u2014 or \u2014NRSO 2 CH\u2550CHCH 2 \u2014; and \n Y is hydrogen, C 1-6  aliphatic optionally substituted with oxo, halogen, NO 2 , or CN, or a 3-10 membered monocyclic or bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein said ring is substituted with 1-4 R e  groups; or \n L is a bivalent C 2-8  straight or branched, hydrocarbon chain wherein one methylene unit of L is replaced by cyclopropylene and one or two additional methylene units of L are independently replaced by \u2014C(O)\u2014, \u2014NRC(O)\u2014, \u2014C(O)NR\u2014, \u2014N(R)SO 2 \u2014, \u2014SO 2 N(R)\u2014, \u2014S\u2014, \u2014S(O)\u2014, \u2014SO 2 \u2014, \u2014OC(O)\u2014, or \u2014C(O)O\u2014; and Y is C 1-6  aliphatic optionally substituted with oxo, halogen, NO 2 , or CN; or \n L is a covalent bond and Y is selected from:\n (ii) C 2-6  alkenyl substituted with oxo, halogen, NO 2 , or CN; or \n (iv) a saturated 3-4 membered heterocyclic ring having 1 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-2 R e  groups; or \n (v) a saturated 5-6 membered heterocyclic ring having 1-2 heteroatoms selected from oxygen or nitrogen wherein said ring is substituted with 1-4 R e  groups; or \n (vi) \n \n \u2003or (vii) a saturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (viii) a partially unsaturated 3-6 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (ix) a partially unsaturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (x) \u2003or (xi) a partially unsaturated 4-6 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (xii) \u2003or (xiii) a 6-membered aromatic ring having 0-2 nitrogens wherein said ring is substituted with 1-4 R e  groups; or (xiv) (xvi) \u2003or (xvii) an 8-10 membered bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or L is \u2014C(O)\u2014 and Y is selected from:\n (i) C 1-6  alkyl substituted with oxo, halogen, NO 2 , or CN; or \n (ii) C 2-6  alkenyl optionally substituted with oxo, halogen, NO 2 , or CN; or \n (iii) C 2-6  alkynyl optionally substituted with oxo, halogen, NO 2 , or CN; or \n (iv) a saturated 3-4 membered heterocyclic ring having 1 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-2 R e  groups; or \n (v) a saturated 5-6 membered heterocyclic ring having 1-2 heteroatoms selected from oxygen or nitrogen wherein said ring is substituted with 1-4 R e  groups; or \n (vi) \n \u2003or (vii) a saturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (viii) a partially unsaturated 3-6 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (ix) a partially unsaturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (x) \u2003or (xi) a partially unsaturated 4-6 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (xii) \u2003or (xiii) a 6-membered aromatic ring having 0-2 nitrogens wherein said ring is substituted with 1-4 R e  groups; or (xiv) \u2003or (xv) a 5-membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-3 R e  groups; or (xvi) \u2003or (xvii) an 8-10 membered bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or L is \u2014N(R)C(O)\u2014 and Y is selected from:\n (i) C 1-6  alkyl substituted with oxo, halogen, NO 2 , or CN; or \n (ii) C 2-6  alkenyl optionally substituted with oxo, halogen, NO 2 , or CN; or \n (iii) C 2-6  alkynyl optionally substituted with oxo, halogen, NO 2 , or CN; or \n (iv) a saturated 3-4 membered heterocyclic ring having 1 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-2 R e  groups; or \n (v) a saturated 5-6 membered heterocyclic ring having 1-2 heteroatoms selected from oxygen or nitrogen wherein said ring is substituted with 1-4 R e  groups; or \n (vi) \n \u2003or (vii) a saturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (viii) a partially unsaturated 3-6 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (ix) a partially unsaturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (x) \u2003or (xi) a partially unsaturated 4-6 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (xii) \u2003or (xiii) a 6-membered aromatic ring having 0-2 nitrogens wherein said ring is substituted with 1-4 R e  groups; or (xiv) \u2003or (xv) a 5-membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-3 R e  groups; or (xvi) \u2003or (xvii) an 8-10 membered bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or L is a bivalent C 1-8  saturated or unsaturated, straight or branched, hydrocarbon chain; and Y is selected from:\n (ii) C 2-6  alkenyl optionally substituted with oxo, halogen, NO 2 , or CN; or \n (iv) a saturated 3-4 membered heterocyclic ring having 1 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-2 R e  groups; or \n (v) a saturated 5-6 membered heterocyclic ring having 1-2 heteroatoms selected from oxygen or nitrogen wherein said ring is substituted with 1-4 R e  groups; or \n (vi) \n \u2003or (vii) a saturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (viii) a partially unsaturated 3-6 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (ix) a partially unsaturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (x) \u2003or (xi) a partially unsaturated 4-6 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (xii) \u2003or (xiii) a 6-membered aromatic ring having 0-2 nitrogens wherein said ring is substituted with 1-4 R e  groups; or (xvii) an 8-10 membered bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or L is \u2014CH 2 \u2014, \u2014NH\u2014, \u2014C(O)\u2014, \u2014CH 2 NH\u2014, \u2014NHCH 2 \u2014, \u2014NHC(O)\u2014, \u2014NHC(O)CH 2 OC(O)\u2014, \u2014CH 2 NHC(O)\u2014, \u2014NHSO 2 \u2014, \u2014NHSO 2 CH 2 \u2014, or \u2014SO 2 NH\u2014; and Y is selected from:\n (ii) C 2-6  alkenyl substituted with oxo, halogen, NO 2 , or CN; or \n (iv) a saturated 3-4 membered heterocyclic ring having 1 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-2 R e  groups; or \n (v) a saturated 5-6 membered heterocyclic ring having 1-2 heteroatoms selected from oxygen or nitrogen wherein said ring is substituted with 1-4 R e  groups; or \n (vi) \n \u2003or (vii) a saturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (viii) a partially unsaturated 3-6 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (ix) a partially unsaturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 R e  groups; or (x) \u2003or (xi) a partially unsaturated 4-6 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; or (xii) \u2003or (xiii) a 6-membered aromatic ring having 0-2 nitrogens wherein said ring is substituted with 1-4 R e  groups; or (xiv) \u2003or (xvi) \u2003or (xvii) an 8-10 membered bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 R e  groups; each R e  is independently selected from -Q-Z, oxo, NO 2 , halogen, CN, C 1-6  saturated aliphatic substituted with halogen, NO 2 , or CN, C 2-6  unsaturated aliphatic optionally substituted with oxo, halogen, NO 2 , or CN, or a suitable leaving group selected from alkoxy, sulfonyloxy, optionally substituted alkylsulfonyloxy, optionally substituted alkenylsulfonyloxy, optionally substituted arylsulfonyloxy, or diazonium, wherein:\n Q is a bivalent C 2-6  unsaturated, straight or branched, hydrocarbon chain, wherein one or two methylene units of Q are optionally and independently replaced by \u2014N(R)\u2014, \u2014S\u2014, \u2014O\u2014, \u2014C(O)\u2014, \u2014OC(O)\u2014, \u2014C(O)O\u2014, \u2014SO\u2014, or \u2014SO 2 \u2014, \u2014N(R)C(O)\u2014, \u2014C(O)N(R)\u2014, \u2014N(R)SO 2 \u2014, or \u2014SO 2 N(R)\u2014; and \n each Z is hydrogen or C 1-6  aliphatic substituted with oxo, halogen, NO 2 , or CN; \n R y  is halogen, \u2014CN, \u2014CF 3 , C 1-4  aliphatic, C 1-4  haloaliphatic, \u2014OR, or \u2014C(O)R; each R group is independently hydrogen or an optionally substituted group selected from C 1  aliphatic, phenyl, a 4-7 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; W 1  is \u2014NR 2 \u2014; W 2  is \u2014NR 2 \u2014; R 2  is hydrogen, optionally substituted C 1-6  aliphatic, or \u2014C(O)R; m is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3 or 4; each instance of R x  is independently selected from \u2014R, \u2014OR, \u2014O(CH 2 ) q OR, or halogen, wherein q is 1, 2, 3 or 4; and each instance of R v  is independently selected from \u2014R, halogen, \u2014OR, \u2014O(CH 2 ) q OR, \u2014CN, \u2014NO 2 , \u2014SO 2 R, \u2014SO 2 N(R) 2 , \u2014SOR, \u2014C(O)R, \u2014CO 2 R, \u2014C(O)N(R) 2 , \u2014NRC(O)R, \u2014NRC(O)N(R) 2 , \u2014NRSO 2 R, or \u2014N(R) 2 , wherein q is 1, 2, 3 or 4.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 94.0
- Lexical Diversity: 1.05882
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13670937', '13671129', '15080351', '12492180', '14296376']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8934967890732132
- 35 USC 102 Novelty (BERT): 0.6189142524674769
- Combined Prediction Score: 0.8660385354126396
- Mean Citation Score: 656.062982
- Max Citation Score: 695.6846
- Similarity Product: 466.53318139500624

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test