PATENT CLAIM ANALYSIS

Application Number: 16087318
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-01
Patent Classification: ["514", "260100"]

Abstract:
The invention relates to a salt form of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene[3,2-d]pyrimidine-6-carboxylic acid and a preparation method for the salt form. Also disclosed is a pharmaceutical composition of the formula I compound salt form. The salt form of the invention provides powerful in vivo hypoglycemic activity and is expected to be a novel pharmaceutical active ingredient for treating or preventing diabetes mellitus type 2 and/or complications of diabetes mellitus type 2

Claim (Index 3):
The salt form of  claim 1  wherein the hydrochloride has one or more characteristics selected from the group consisting of:\n (1) the hydrochloride is a crystal; and/or \n (2) the X-ray powder diffraction pattern of the hydrochloride crystal includes 3 or more 2\u03b8 values selected from the group consisting of: 7.43\u00b10.2\u00b0, 11.06\u00b10.2\u00b0, 11.70\u00b10.2\u00b0, 13.46\u00b10.2\u00b0, 15.03\u00b10.2\u00b0, 15.34\u00b10.2\u00b0, 18.32\u00b10.2\u00b0, 21.96\u00b10.2\u00b0, 24.01\u00b10.2\u00b0, 27.20\u00b10.2\u00b0, 29.32\u00b10.2\u00b0, 30.26\u00b10.20; and/or \n (3) in the differential scanning calorimetry analysis spectrum (DSC spectrum) of the hydrochloride crystal, there is no melting peak before decomposition; and/or \n (4) in the TG diagram of the hydrochloride crystal, there is a characteristic absorption peak at 272\u00b12\u00b0 C.; and/or \n (5) the thermal weight loss of the hydrochloride crystal is 64-65 wt % at 400\u00b0 C.; and/or \n (6) the weight gain of the hydrochloride crystal is calculated to be \u22643%, preferably \u22641%, more preferably \u22640.3%, after being placed in a desiccator having a humidity of 50% for 24 hours and taken out; and/or \n (7) the IR pattern of the hydrochloride crystal includes three or more characteristic absorption peaks represented by the wavelength \u03bb selected from the group consisting of: 3429\u00b12 cm \u22121 , 2951\u00b12 cm \u22121 , 2827\u00b12 cm \u22121 , 2225\u00b12 cm \u22121 , 1720\u00b12 cm \u22121 , 1687\u00b12 cm \u22121 , 1560\u00b12 cm \u22121 , 1533\u00b12 cm \u22121 , 1446\u00b12 cm \u22121 , 1385\u00b12 cm \u22121 , 1261\u00b12 cm \u22121 , 1064\u00b12 cm \u22121 , 771\u00b12 cm \u22121 .

Metadata:
- Claim Count in Document: 20.0
- Percentile: 97.0
- Lexical Diversity: 1.54545
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16087317', '16316055', '13522549', '14698463', '15746966']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7755987768503851
- 35 USC 102 Novelty (BERT): 0.5193872171691921
- Combined Prediction Score: 0.7499776208822659
- Mean Citation Score: 261.05123
- Max Citation Score: 316.59814
- Similarity Product: 273.1134726084352

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test