PATENT CLAIM ANALYSIS

Application Number: 15874485
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "252040"]

Abstract:
Compounds and compositions are presented that inhibit K-Ras, and especially mutant K-Ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

Claim (Index 1):
A compound having a structure according to Formula I wherein R 6  has the structure according to either Formula II or Formula III wherein: V represents C(R 5 ) or N; W represents C(R 1 ) or N; X represents C(R 2 ) or N; Y represents C(R 3 ) or N; Z represents O, S, C(R 4a )(R 4b ) or N(R 4a ); wherein R 1  is selected from the group consisting of H, alkyl, and cycloalkyl; wherein R 2  is selected from the group consisting of H, halo, alkyl, substituted alkyl, fluoroalkyl, cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, aralkyl, polycycloalkyl, hetero-polycycloalkyl, polycycloaryl, hetero-polycycloaryl, acyloxy, alkyloxycarbonyl, amino, amido, sulfonamido, pyrazolyl, and substituted pyrazolyl; wherein R 3  and R 7  are independently H or halo; wherein R 4a  is independently selected from the group consisting of H, alkyl, substituted alkyl, fluoroalkyl, and aryl; wherein R 4b  are independently selected from the group consisting of H, alkyl, substituted alkyl, fluoroalkyl, aryl, and alkyloxy; wherein R 5  is H or alkyl; and wherein R 8  is selected from the group consisting of H, substituted alkyl, aminoalkyl, alkyl amido, cycloalkyl, aralkyl, substituted aralkyl, heteroaralkyl, substituted heteroaralkyl, alkyl cycloalkyl, alkyl heterocycloalkyl, polycycloaryl, alkyloxy, acyloxy, alkyloxycarbonyl, and amino.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 86.0
- Lexical Diversity: 1.36
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15563813', '15093951', '15805716', '15566648', '14511425']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8126920293619563
- 35 USC 102 Novelty (BERT): 0.5304161752714182
- Combined Prediction Score: 0.7844644439529025
- Mean Citation Score: 304.510234
- Max Citation Score: 360.2005
- Similarity Product: 248.3450960659385

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test