PATENT CLAIM ANALYSIS

Application Number: 16266782
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "278000"]

Abstract:
The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R 1  to R 5  are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.

Claim (Index 1):
A compound of formula (I)\n wherein L is \u2014(CHR 8 ) m \u2014(CHR 9 ) n \u2014(CO) q \u2014 R 1  is \u2014NR 6 R 7 , aryl or C 3-7  cycloalkyl, wherein each aryl and C 3-7  cycloalkyl is optionally substituted with one or more R 1\u2032 ; each R 1\u2032  is independently selected from halogen, cyano, C 1-7  alkyl, halo-C 1-7  alkyl, C 3-7  cycloalkyl, C 3-7  cycloalkyl-C 1-7  alkyl, phenyl, benzyl, amino, hydroxy, C 1-7  alkoxy, halo-C 1-7  alkoxy, C 1-7  alkoxy-C 1-7  alkyl, oxo, \u2014CH 2 \u2014OR 16 , \u2014C(O)\u2014OR 16 , \u2014CH 2 \u2014NHR 16 , \u2014CH 2 \u2014CH 2 \u2014NR 17 R 18 , \u2014CH 2 \u2014C(O)\u2014NHR 16  and \u2014C(O)\u2014NHR 16 ; or two R 1\u2032  together are \u2014(CR 12 R 13 ) s \u2014; R 2  is hydrogen, fluorine, C 1-7  alkyl, or halo-C 1-7  alkyl; R 3  is hydrogen or C 1-7  alkyl; R 4  is aryl optionally substituted by one or more R 4\u2032 ; each R 4\u2032  is independently selected from halogen, cyano, C 1-7  alkyl, halo-C 1-7  alkyl, C 3-7  cycloalkyl, amino, hydroxy, C 1-7  alkoxy and halo-C 1-7  alkoxy; R 5  is 1H-pyrazolo[3,4-b]pyridine which is optionally substituted with one or more R 5 \u2032; each R 5\u2032  is independently selected from halogen, cyano, C 1-7  alkyl, halo-C 1-7  alkyl, C 3-7  cycloalkyl, amino, hydroxy, C 1-7  alkoxy and \u2014C(O)NH 2 ; R 6  is C 1-7  alkyl, halo-C 1-7  alkyl, hydroxy-C 1-7  alkyl, C 1-7  alkoxy-C 1-7  alkyl, C 3-7  cycloalkyl, aryl, \u2014CH 2 \u2014CH 2 \u2014NR 17 R 18 , wherein C 1-7  alkyl, C 3-7  cycloalkyl, aryl or benzyl are optionally substituted with one or more R 6\u2032 ; each R 6\u2032  is independently selected from halogen, cyano, C 1-7  alkyl, halo-C 1-7  alkyl, C 3-7  cycloalkyl, amino, hydroxy, C 1-7  alkoxy, halo-C 1-7  alkoxy, C 1-7  alkoxy-C 1-7  alkyl, oxo, \u2014CH 2 \u2014C(O)\u2014NHR 16 , phenyl or benzyl said phenyl optionally substituted with C 1-7  alkyl; R 7  is hydrogen, C 1-7  alkyl, C 3-7  cycloalkyl or halo-C 1-7  alkyl; R 8  is hydrogen, C 1-7  alkyl, hydroxy-C 1-7  alkyl, C 1-7  alkoxy-C 1-7  alkyl, halo-C 1-7  alkoxy-C 1-7  alkyl, \u2014(CH 2 ) r -phenyl, or \u2014(CH 2 ) r NR 10 R 11 ; R 9  is hydrogen, C 1-7  alkyl, or halo-C 1-7  alkyl; R 10  and R 11  are independently selected from hydrogen and C 1-7  alkyl; R 12 , R 13 , R 14  and R 15  are each independently selected from hydrogen, halogen and C 1-7  alkyl; R 16  is hydrogen, C 1-7 alkyl, halo-C 1-7  alkyl or C 3-7  cycloalkyl; R 17  and R 18  are independently selected from hydrogen and C 1-7  alkyl; m is 0, 1 or 2; n is 0, 1 or 2; q is 0 or 1; r is 0, 1 or 2; s is 2, 3 or 4; or a pharmaceutically acceptable salt thereof; with the proviso that if R 1  is \u2014NR 6 R 7  then:\n if q=0 then m+n\u22652, or \n if q=1 then m+n\u22651.

Metadata:
- Claim Count in Document: 54.0
- Percentile: 99.0
- Lexical Diversity: 1.25
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15850826', '16057436', '15300762', '13822840', '11524978']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7798445076519278
- 35 USC 102 Novelty (BERT): 0.6697787216669424
- Combined Prediction Score: 0.7688379290534293
- Mean Citation Score: 435.21528
- Max Citation Score: 646.1227
- Similarity Product: 634.9943743501067

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test