PATENT CLAIM ANALYSIS

Application Number: 15870663
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "044000"]

Abstract:
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.

Claim (Index 1):
A method to obtain an antibody or fragment thereof that binds to an antigen, the method comprising:\n obtaining a population of B cells producing antigen specific antibodies from a non-human transgenic animal that has been immunized with said antigen, wherein said transgenic animal comprises a transgene encoding a rearranged human immunoglobulin variable region and wherein the transgene comprises an immunoglobulin constant region or said rearranged human immunoglobulin variable region is operatively linked to an endogenous immunoglobulin constant region, and wherein the transgenic animal produces a repertoire of antibodies that bind said antigen having the rearranged human immunoglobulin variable region encoded by said transgene and a counterpart immunoglobulin variable region produced by somatic recombination; isolating nucleic acid comprising a nucleotide sequence encoding at least said counterpart human immunoglobulin variable region from said population of B cells producing antigen specific antibodies; expressing a nucleotide sequence that encodes said counterpart immunoglobulin variable region and a nucleotide sequence encoding said rearranged human immunoglobulin variable region in a host cell to produce said antibody or fragment; and recovering the antibody or fragment that binds to the antigen.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 1.56452
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14266540', '13750753', '14265046', '15140321', '10577061']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.3979927177907488
- 35 USC 102 Novelty (BERT): 0.7169963587073793
- Combined Prediction Score: 0.4298930818824118
- Mean Citation Score: 707.2358740000003
- Max Citation Score: 842.716
- Similarity Product: 738.2088075842858

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test