PATENT CLAIM ANALYSIS

Application Number: 15879821
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["514", "04400A"]

Abstract:
A unit structure consists of a single nucleic acid having a length of 10 to 30 bases, and a single block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. In this unit structure: (i) a difference between a total of positive charges derived from cationic groups of the cationic polyamino acid segment and a total of negative charges derived from the nucleic acid in the unit structure falls within a range of ±10% of the total of the negative charges derived from the nucleic acid, (ii) the hydrophilic polymer chain segment comprises polyethylene glycol, (iii) the polyethylene glycol has a radius of inertia (Rg) equal to or longer than the length of the nucleic acid, and (iv) the cationic polyamino acid segment is bound to the nucleic acid via electrostatic bonds.

Claim (Index 12):
The unit structure according to  claim 8 , wherein the block copolymer is selected from the group consisting of the following formulae (1)-(2): wherein:\n R 1a  to R 1d  are each independently a hydrogen atom, an unsubstituted or substituted linear or branched alkyl group having 1 to 12 carbon atoms, or a group represented by the following formula (I): \n where k represents an integer of from 1 to 5, and D represents a target binding site; R 2  is a hydrogen atom, an unsubstituted or substituted linear or branched alkyl group having 1 to 12 carbon atoms, or an unsubstituted or substituted linear or branched alkylcarbonyl group having 1 to 24 carbon atoms; R 3  is a hydroxyl group, an unsubstituted or substituted linear or branched alkyloxy group having 1 to 12 carbon atoms, an unsubstituted or substituted linear or branched alkenyloxy group having 2 to 12 carbon atoms, an unsubstituted or substituted linear or branched alkynyloxy group having 2 to 12 carbon atoms, or an unsubstituted or substituted linear or branched alkyl-substituted imino group having 1 to 12 carbon atoms; R 4a  and R 4b  are each independently a methylene group or an ethylene group; R 5a  and R 5b  are the same group or different groups selected from the group consisting of:\n \u2014NH\u2014(CH 2 ) p1 \u2014[NH\u2014(CH 2 ) q1 \u2014] r1 NH 2 \u2003\u2003(i); \n \u2014NH\u2014(CH 2 ) p2 \u2014N[\u2014(CH 2 ) q2 \u2014NH 2 ] 2 \u2003\u2003(ii); \n \u2014NH\u2014(CH 2 ) p3 \u2014N{[\u2014(CH 2 ) q3 \u2014NH 2 ][\u2014(CH 2 ) q4 \u2014NH\u2014] r2 H}\u2003\u2003(iii); and \n \u2014NH\u2014(CH 2 ) p4 \u2014N{\u2014(CH 2 ) q5 \u2014N[\u2014(CH2) q6 \u2014NH 2 ] 2 } 2 \u2003\u2003(iv), \n where p1 to p4, q1 to 6, and r1 to 2 are each independently an integer of from 1 to 5; Q is \u2014NH 2 , \u2014NHC(\u2550NH) NH 2 , or a group represented by the following formula (II); L is a divalent linking group or a valence bond; x1 to x4 are each independently an integer of from 454 to 1818; y, z, and v are each independently an integer of from 0 to 30, provided that y, z, and v satisfy the relationship 10\u2264y+z+v\u226430; w is an integer of from 1 to 6; l and m are each independently an integer of from 0 to 5; and n is 1.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 2.29851
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14395745', '12922116', '13258663', '14358816', '13808237']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8145241993582604
- 35 USC 102 Novelty (BERT): 0.5752516052019097
- Combined Prediction Score: 0.7905969399426254
- Mean Citation Score: 327.965946
- Max Citation Score: 463.4832
- Similarity Product: 437.4233589766503

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test