PATENT CLAIM ANALYSIS

Application Number: 16331579
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "260100"]

Abstract:
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to fused bicyclic compounds, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MDS) and diabetes.

Claim (Index 3):
The compound according to  claim 1 , wherein\n (a) L 2  is selected from the group consisting of >SO 2 , >CR 4a R 4b , and \u2014CHR 4a CHR 5 \u2014;\n wherein\n R 4a  is selected from the group consisting of hydrogen; \u2014C(\u2550O)NR 7a R 7b ; C 1-4 alkyl optionally substituted with a substituent selected from the group consisting of fluoro, \u2014CN, \u2014OR 8 , and \u2014NR 9a R 9b ; and C-linked 4- to 7-membered non-aromatic heterocyclyl containing at least one nitrogen, oxygen or sulfur atom; \n R 4b  is selected from the group consisting of hydrogen and methyl; or \n R 4a  and R 4b  together with the carbon atom to which they are attached form a C 3-5 cycloalkyl or a C-linked 4- to 6-membered heterocyclyl containing an oxygen atom; \n R 5  is selected from the group consisting of hydrogen; \u2014OR 6 ; \u2014NR 7a R 7b ; \u2014C(\u2550O)NR 7a R 7b ; C 1-4 alkyl optionally substituted with a substituent selected from the group consisting of fluoro, \u2014CN, \u2014OR 8 , and \u2014NR 9a R 9b ; and C-linked 4- to 7-membered non-aromatic heterocyclyl containing at least one nitrogen, oxygen or sulfur atom; wherein \n R 6 , R 7a , R 7b , R 8 , R 9a  and R 9b  are each independently selected from the group consisting of hydrogen; C 1-4 alkyl optionally substituted with a substituent selected from the group consisting of fluoro, \u2014CN and \u2014C(\u2550O)NR 10a R 10b ; and C 2-4 alkyl substituted with a substituent selected from the group consisting of \u2014OR 11  and \u2014NR 10a R 10b ; wherein \n R 10a , R 10b  and R 11  are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; and \n R 3  is selected from the group consisting of Ar; Het 1 ; Het 2 ; and a 7- to 10-membered saturated spirocarbobicyclic system; or \n \n (b) L 2  is selected from >CR 4c R 4d , and \u2014CHR 4c CHR 5a \u2014; wherein R 4c , R 4d  and R 5a  are each independently selected from the group consisting of hydrogen; and C 1-4 alkyl; and\n R 3  is selected from the group consisting of \n wherein R 12a , R 12b , and R 12c  are each independently selected from the group consisting of C 1-6 alkyl optionally substituted with a \u2014OH or a \u2014NH 2  substituent; or (c) -L 2 -R 3  is C 1-6 alkyl optionally substituted with one, two or three fluoro substituents; or (d) -L 2 -R 3  is wherein R 13  is hydrogen; or (e) -L 2 -R 3  is and wherein Ar is phenyl optionally substituted with one, two, or three substituents each independently selected from the group consisting of halo, \u2014CN, and C 1-4 alkyl optionally substituted with a substituent selected from the group consisting of fluoro, \u2014CN, \u2014OR 20 , \u2014NR 21a R 21b , and \u2014C(\u2550O)NR 21a R 21b ; Het 1  is a monocyclic heteroaryl selected from the group consisting of pyridyl, 4-, 5- or 6-pyrimidinyl, pyrazinyl, pyridazinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, 4- or 5-thiazolyl, isothiazolyl, and isoxazolyl; each of which may be optionally substituted with one, two, or three substituents each independently selected from the group consisting of halo, \u2014CN, and C 1-4 alkyl optionally substituted with a substituent selected from the group consisting of fluoro, \u2014CN, \u2014OR 20 , \u2014NR 21a R 21b , and \u2014C(\u2550O)NR 21a R 21b ; and Het 2  is a non-aromatic heterocyclyl selected from azetidinyl, pyrrolidinyl and piperidinyl; wherein R 20 , R 21a , and R 21b  are each independently selected from the group consisting of hydrogen and C 1-4 alkyl.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 99.0
- Lexical Diversity: 1.34146
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15766887', '15537619', '15976037', '15537551', '15976223']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7910324475620772
- 35 USC 102 Novelty (BERT): 0.5166456344695308
- Combined Prediction Score: 0.7635937662528227
- Mean Citation Score: 294.28313799999995
- Max Citation Score: 308.84235
- Similarity Product: 259.7326489525974

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test