PATENT CLAIM ANALYSIS

Application Number: 15952234
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "264110"]

Abstract:
Provided are a hydroxyethyl sulfonate of a cyclin-dependent protein kinase inhibitor, a crystalline form thereof and a preparation method therefor. Specifically, 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperidin-4-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydroxyethyl sulfonate (compound of formula (I)), a crystal form I thereof and a preparation method therefor are provided. Crystal form I of the compound of formula (I) has good chemical and crystalline stability, low toxicity, and low residual crystallization solvent. The compound of formula (I) and crystal form I thereof can be used in improved clinical therapy.

Claim (Index 28):
A crystal of the compound of  claim 11  prepared by a method comprising:\n (a) dissolving tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidine-1-formate and hydroxyethyl sulfonic acid, or any crystal form or amorphous form of the compound of formula (I) into a crystallization solvent to precipitate a crystal, wherein the crystallization solvent is selected from the group consisting of water, an organic solvent, and mixtures thereof; the organic solvent is selected from the group consisting of alcohols, ketones, nitriles each of which having 3 or less carbon atoms, and mixtures thereof or alternatively the organic solvent is a mixed solvent of a halogenated hydrocarbon having 3 or less carbon atoms and at least one solvent selected from the group consisting of alcohols, ketones, and nitriles each of which having 3 or less carbon atoms; and \n (b) filtering the crystal, then washing and drying the filtered crystal.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 91.0
- Lexical Diversity: 1.98276
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15546405', '16310369', '15559516', '15516529', '11861958']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7819951267534389
- 35 USC 102 Novelty (BERT): 0.5593523338052194
- Combined Prediction Score: 0.759730847458617
- Mean Citation Score: 303.985086
- Max Citation Score: 448.03943
- Similarity Product: 345.08253901198145

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test