PATENT CLAIM ANALYSIS

Application Number: 15924020
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "210210"]

Abstract:
A series of fused bicyclic heteroaromatic derivatives of formula (IA) or (IB), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.

Claim (Index 1):
A compound of formula (IB) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: wherein X represents N or CH; T represents C\u2014R 2 ; U represents N\u2014R 4 ; Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe): in which the asterisk (*) represents the point of attachment to the remainder of the molecule; V represents \u2014CH 2 \u2014, \u2014C(CH 3 ) 2 \u2014, \u2014CH 2 CH 2 \u2014 or \u2014CH 2 CH 2 CH 2 \u2014; W represents the residue of a C 3-7  cycloalkyl group; Y represents a covalent bond, or a linker group selected from \u2014C(O)\u2014, \u2014S(O)\u2014, \u2014S(O) 2 \u2014, \u2014C(O)O\u2014, \u2014C(O)N(R 5 )\u2014, \u2014C(O)C(O)\u2014 and \u2014S(O) 2 N(R 5 )\u2014, or a linker group of formula (Ya): in which the asterisk (*) represents the point of attachment to the remainder of the molecule; Z represents hydrogen; or Z represents C 1-6  alkyl, C 2-6  alkenyl, C 3-7  cycloalkyl, C 3-7  cycloalkyl(C 1-6 )alkyl, C 3-7  heterocycloalkyl, C 3-7  heterocycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents; A 1  represents hydrogen, cyano or trifluoromethyl; or A 1  represents C 1-6  alkyl, optionally substituted by one or more substituents independently selected from fluoro, \u2014OR a , trifluoromethoxy, -\u2014NR b R c , CO 2 R d  and \u2014CONR b R c ; or A 1  represents C 3-7  cycloalkyl; A 2  represents hydrogen or C 1-6  alkyl; R 1  and R 2  independently represent hydrogen, halogen, cyano, nitro, hydroxy, trifluoromethyl, trifluoromethoxy, \u2014OR a , \u2014SR a , \u2014SOR a , \u2014SO 2 R a , \u2014NR b R c , \u2014CH 2 NR b R c , \u2014NR c COR d , \u2014CH 2 NR c COR d , \u2014NR c CO 2 R d , \u2014NHCONR b R c , \u2014NR c SO 2 R e , \u2014N(SO 2 R e ) 2 , \u2014NHSO 2 NR b R c , \u2014COR d , \u2014CO 2 R d , \u2014CONR b R c , \u2014CON(OR a )R b  or \u2014SO 2 NR b R c ; or C 1-6  alkyl, C 3-7  cycloalkyl, C 3-7  cycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, C 3-7  heterocycloalkyl, C 3-7  heterocycloalkyl(C 1-6 )alkyl, C 3-7  heterocycloalkenyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents; R 3  represents hydrogen, halogen or C 1-6  alkyl; R 4  represents hydrogen; or R 4  represents C 1-6  alkyl, aryl, aryl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents; R 5  represents hydrogen; or R 5  represents C 1-6  alkyl, optionally substituted by one or more substituents independently selected from \u2014OR a  and \u2014NR b R c ; R a  represents hydrogen; or R a  represents C 1-6  alkyl, aryl, aryl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more sub stituents; R b  and R c  independently represent hydrogen or trifluoromethyl; or C 1-6  alkyl, C 3-7  cycloalkyl, C 3-7  cycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, C 3-7  heterocycloalkyl, C 3-7  heterocycloalkyl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents; or R b  and R c , when taken together with the nitrogen atom to which they are both attached, represent azetidin-1-yl, pyrrolidin-1-yl, oxazolidin-3-yl, isoxazolidin-2-yl, thiazolidin-3-yl, isothiazolidin-2-yl, piperidin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, piperazin-1-yl, homopiperidin-1-yl, homomorpholin-4-yl or homopiperazin-1-yl, any of which groups may be optionally substituted by one or more substituents; R d  represents hydrogen; or C 1-6  alkyl, C 3-7  cycloalkyl, aryl, C 3-7  heterocycloalkyl or heteroaryl, any of which groups may be optionally substituted by one or more sub stituents; and R e  represents C 1-6  alkyl, aryl or heteroaryl, any of which groups may be optionally substituted by one or more sub stituents.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 90.0
- Lexical Diversity: 1.30612
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15318422', '15318507', '14357340', '14432842', '15513357']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7940382953600954
- 35 USC 102 Novelty (BERT): 0.5639941789580922
- Combined Prediction Score: 0.7710338837198951
- Mean Citation Score: 396.094192
- Max Citation Score: 420.13782
- Similarity Product: 396.9115119882201

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test