PATENT CLAIM ANALYSIS

Application Number: 15876367
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "054000"]

Abstract:
Methods and compositions of the invention relate to the enhancement of specific immunotherapies in cancer treatment. In particular, aspects of the invention relate to novel approaches to boost immune function using a complex carbohydrate pharmaceutical compound alone or in combination with other targeted immunotherapy to increase the efficacy of immunotherapy of cancer.

Claim (Index 1):
A composition comprising:\n a. a therapeutically effective amount of an galactoarabino-rhamnogalacturonate compound comprising a complex carbohydrate backbone of a 1,4-linked galacturonic acid (GalA) and 1,4-linked methyl galacturonate (MeGalA) residues with interspersed \u03b1-1,2 linked rhamnose within the carbohydrate backbone, the rhamnose residues carrying a primary branching of oligomers of 1,4-\u03b2-D-galactose residues, 1,5-\u03b1-L-arabinose residues, or combinations thereof, wherein the molar percent of the oligomers of 1,4-13-D-galactose residues and 1,5-\u03b1-L-arabinose residues is greater than 10% of the total carbohydrate molar content, wherein the 1,4-\u03b2-D-galactose, and 1,5-\u03b1-L-arabinose residues are present in a 2:1 to a 3:1 ratio and wherein the galactoarabino-rhamnogalacturonate has a methyl galacturonate to galacturonic acid ratio ranging from 2:1 to 1:2; and b. a therapeutically effective amount of an immune modulatory agent or a vaccine directed against 4-1BB, 4-1BBL, LAG-3, CD80, CD86, CD134, CD27, CD70, ICOS, ICOS ligand, or combinations thereof.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 86.0
- Lexical Diversity: 1.41026
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14029505', '13999389', '15087119', '15478599', '13998197']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7707925699832613
- 35 USC 102 Novelty (BERT): 0.8000904878005883
- Combined Prediction Score: 0.7737223617649941
- Mean Citation Score: 550.234246
- Max Citation Score: 987.4825
- Similarity Product: 983.4213782063124

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test