PATENT CLAIM ANALYSIS

Application Number: 16123898
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-08
Patent Classification: ["514", "299000"]

Abstract:
The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group including HFI-419, HA-08, AL-40, HFI-437, Val-Tyr-Ile-His-Pro-Phe (otherwise known as angiotensin IV or ANG IV), c[Cys-Tyr-Cys]-His-Pro-Phe, and c[Hcy-Tyr-Hcy]-His-Pro-Phe.

Claim (Index 26):
A compound having a structure according to Formula (I): wherein A is aryl, heteroaryl carbocyclyl or heterocyclyl, each of which may be optionally substituted, when R 1  is NHCOR 8 ;\n or quinolinyl, isoquinolinyl, cinnolinyl, quinazolinyl, quinoxalinyl, 1,8-naphthyridyl, phthalazinyl or pteridinyl, each of which may be optionally substituted, when R 1  is NR 7 R 8 , NHCOR 8 , N(COR 8 ) 2 , N(COR 7 )(COR 8 ), N\u2550CHOR 8  or N\u2550CHR 8 ; \n X is O, NR\u2032 or S, wherein R\u2032 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted acyl, optionally substituted heteroaryl, optionally substituted carbocyclyl or optionally substituted heterocyclyl; R 7  and R 8  are independently selected from hydrogen, optionally substituted alkyl, optionally substituted aryl, or R 7  and R 8 , together with the nitrogen atom to which they are attached form a 3-8-membered ring which may be optionally substituted; R 2  is CN, CO 02 R 9 , C(O)O(O)R 9 , C(O)R 9  or C(O)NR 9 R 10  wherein R 9  and R 10  are independently selected from alkyl, alkenyl, alkynyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, each of which may be optionally substituted, and hydrogen; or R 9  and Ro 1  together with the nitrogen atom to which they are attached, form a 3-8-membered ring which may be optionally substituted; R 3 -R 6  are independently selected from hydrogen, halo, nitro, cyano alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, alkynyloxy, aryloxy, heteroaryloxy, heterocyclyloxy, amino, acyl, acyloxy, carboxy, carboxyester, methylenedioxy, amido, thio, alkylthio, alkenylthio, alkynylthio, arylthio, heteroarylthio, heterocyclylthio, carbocyclylthio, acylthio and azido, each of which may be optionally substituted where appropriate, or any two adjacent R 3 -R 6 , together with the atoms to which they are attached, form a 3-8-membered ring which may be optionally substituted; and Y is hydrogen or C 1-10 alkyl, or a pharmaceutically acceptable salt or solvate thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.45098
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15747697', '12309010', '14772334', '14317602', '15083836']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7329389658660573
- 35 USC 102 Novelty (BERT): 0.6698786736578738
- Combined Prediction Score: 0.7266329366452391
- Mean Citation Score: 354.693118
- Max Citation Score: 658.3663
- Similarity Product: 624.4270261174082

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test