PATENT CLAIM ANALYSIS

Application Number: 16131110
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["424", "143100"]

Abstract:
The present invention generally relates to antibodies specific for asialoglycoprotein receptor (ASGPR) and their use for selectively delivering effector moieties that influence cellular activity. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies of the invention, and to methods of using them in the treatment of disease.

Claim (Index 9):
The affinity matured variant antibody of  claim 8 , wherein the antibody comprises a modification within the interface between the two antibody heavy chains in the CH3 domain, wherein i) in the CH3 domain of one heavy chain, an amino acid residue is replaced with an amino acid residue having a larger side chain volume, thereby generating a protuberance (\u201cknob\u201d) within the interface in the CH3 domain of one heavy chain which is positionable in a cavity (\u201chole\u201d) within the interface in the CH3 domain of the other heavy chain, and ii) in the CH3 domain of the other heavy chain, an amino acid residue is replaced with an amino acid residue having a smaller side chain volume, thereby generating a cavity (\u201chole\u201d) within the interface in the second CH3 domain within which a protuberance (\u201cknob\u201d) within the interface in the first CH3 domain is positionable.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 97.0
- Lexical Diversity: 1.63043
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14419824', '15711495', '15067024', '13205743', '15879260']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8086997004192322
- 35 USC 102 Novelty (BERT): 0.6594946218713604
- Combined Prediction Score: 0.7937791925644451
- Mean Citation Score: 481.664678
- Max Citation Score: 651.7915
- Similarity Product: 625.2058042993548

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test