PATENT CLAIM ANALYSIS

Application Number: 15956133
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-04
Patent Classification: ["514", "017700"]

Abstract:
Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

Claim (Index 52):
The method of  claim 1 , wherein the necrosis inhibitor is a compound of Formula III: or a pharmaceutically acceptable salt, an ester, or a prodrug thereof, wherein: Z is \u2014CH 2 \u2014, \u2014CH 2 CH 2 \u2014, \u2014O\u2014, \u2014S\u2014, \u2014S(O)\u2014, \u2014S(O 2 )\u2014, or \u2014N(R 7 )\u2014; R 1 , R 3 , and R 5  each represent independently for each occurrence hydrogen, halogen, hydroxyl, amino, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, C 1 -C 6 alkanoyl, C 1 -C 6 alkylsulfinyl, C 1 -C 6 alkylsulfinyl-C 1 -C 6 alkyl, C 1 -C 6 alkylsulfonyl, C 1 -C 6 alkylsulfonyl-C 1 -C 6 alkyl, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl; R 2  and R 4  are C 1 -C 6 alkoxy; R 6  is \u2014C(O)R 8 , \u2014C(S)R 8 , \u2014C(O)OR 8 , \u2014C(O)NR 8 R 9 , \u2014C(S)NR 8 R 9 , \u2014C(NH)R 8 , or \u2014S(O 2 )R 8 ; R 7  is alkyl, aralkyl, or heteroaralkyl; R 8  and R 9  each represent independently hydrogen, C 1 -C 6 alkyl, heteroalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl; and n represents independently for each occurrence 0, 1, or 2.

Metadata:
- Claim Count in Document: 73.0
- Percentile: 91.0
- Lexical Diversity: 1.66102
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15093480', '15288214', '14934810', '12086792', '15100967']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7825784654020466
- 35 USC 102 Novelty (BERT): 0.7313824739854969
- Combined Prediction Score: 0.7774588662603916
- Mean Citation Score: 535.4984059999998
- Max Citation Score: 823.15753
- Similarity Product: 779.5952617708148

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test