PATENT CLAIM ANALYSIS

Application Number: 15750087
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["544", "118000"]

Abstract:
We provide diastereomerically pure or substantially diastereomerically pure activated phosphoramidochloridate morpholino nucleosides, methods of their preparation, and methods of their use in stereospecific coupling for stereospecific synthesis of diastereomerically pure phosphorodiamidate morpholino oligomers (PMOs).

Claim (Index 1):
A substantially diastereomerically pure compound selected from the group consisting of the compound of Formula 20, the compound of Formula 21, the compound of Formula 22, the compound of Formula 23, the compound of Formula 24, the compound of Formula 25, the compound of Formula 26, the compound of Formula 27, the compound of Formula 28, the compound of Formula 29, the compound of Formula 30, and the compound of Formula 31, Compound Formula # 20   21   22   23   24   25   26   27   28   29   30   31 wherein R 1  and R 2  may be the same or different, and are selected from the group consisting of \u2014H, optionally substituted C 1 -C 3  alkyl, optionally substituted phenyl, optionally substituted naphthyl, or, with the nitrogen to which they are attached, form an optionally substituted heterocycle, which may be, for example, pyrrolidine, piperazine, and morpholine; wherein R 3  is selected from the group consisting of trityl (Tr), which may be substituted trityl, including but not limited to such as MMTr (p-methoxyphenyldiphenylmethyl); optionally substituted benzyl, 4-methoxybenzyl (PMB, MPM), 3,4-dimethoxybenzyl, diphenylmethyl (Dpm), 4-methoxybenzyl, and sulfonyl; R 4 , R 5 , and R a  are selected from the group consisting of \u2014H, \u2014C(O)R T , and \u2014C(O)OR 7 , where R 7  is C1-C6 alkyl, benzyl, 2,2,2-trichloroethyl, and aryl; R 9  is selected from the group consisting of optionally substituted alkyl, cyanoethyl, acyl, carbonate, carbamate, optionally substituted benzyl, 4-pivaloyloxy benzyl, and silyl, and enantiomers thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.39286
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14455116', '15109616', '13512873', '15632027', '13836168']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7531827948259335
- 35 USC 102 Novelty (BERT): 0.5176221869374811
- Combined Prediction Score: 0.7296267340370883
- Mean Citation Score: 193.27695
- Max Citation Score: 207.06187
- Similarity Product: 105.81295526038588

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test