PATENT CLAIM ANALYSIS

Application Number: 16192752
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["424", "184100"]

Abstract:
The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.

Claim (Index 1):
A method for treating a cancer in a patient, wherein the method comprises\n (a) exposing a microbiota in the patient to a guided nuclease to selectively target the genome of cells of a first species in the microbiota using the guided nuclease, wherein the first species is a bacterial or archaeal species; and simultaneously or sequentially administering to the patient an effective amount of an immunotherapy; and (b) allowing the guided nuclease to cut one or more target nucleotide sequences comprised by first cells of a first strain of the first species, thereby killing the first cells or reducing the growth thereof, whereby the proportion of the first cells comprised by the microbiota is reduced; wherein (c) the selective targeting avoids targeting second cells comprised by the microbiota, wherein the second cells are of a different strain or a different species from the first cells; and (d) the reducing of the proportion of the first cells modulates immune cells in the patient, whereby the efficacy of the immunotherapy is enhanced for treatment of the cancer in the patient.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 98.0
- Lexical Diversity: 1.67857
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16041595', '16028311', '15820296', '15160405', '16192746']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.752601248565573
- 35 USC 102 Novelty (BERT): 0.5786609478969977
- Combined Prediction Score: 0.7352072184987154
- Mean Citation Score: 393.647904
- Max Citation Score: 463.46164000000016
- Similarity Product: 355.12980873505126

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test