PATENT CLAIM ANALYSIS

Application Number: 16023972
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["435", "007200"]

Abstract:
Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.

Claim (Index 38):
A method of optimizing a non-luminescent pair comprising:\n (a) aligning the sequences of three or more related proteins; (b) determining a consensus sequence for the related proteins; (c) providing first and second fragments of a protein related to three or more proteins, wherein the fragments are individually substantially non-luminescent but exhibit luminescence upon stable interaction of the fragments; (d) mutating the first and second fragments at one or more positions each, wherein said mutations alter the sequences of the fragments to be more similar to a corresponding portion of the consensus sequence, wherein the mutating results in a non-luminescent pair that are not fragments of a preexisting protein, (e) testing the non-luminescent pair for the absence of luminescence when unassociated and luminescence upon stable association of the non-luminescent pair.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 94.0
- Lexical Diversity: 1.25
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14209546', '14209610', '15073249', '15717534', '15899219']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8385984900078736
- 35 USC 102 Novelty (BERT): 0.6628476988671727
- Combined Prediction Score: 0.8210234108938035
- Mean Citation Score: 848.3068059999997
- Max Citation Score: 895.93604
- Similarity Product: 632.0849114750957

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test