PATENT CLAIM ANALYSIS

Application Number: 16175206
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "384000"]

Abstract:
The invention provides novel compounds having the general formula I: wherein R 1 , R B1 , R B2 , n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

Claim (Index 1):
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein\n R 1  is selected from the group consisting of C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, CH 2 \u2014(C 3 -C 6  cycloalkyl), C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 1 -C 6  alkyl-N(R N ) 2 , phenyl, benzyl, 4 to 8 membered heterocyclyl and 5 to 6 membered heteroaryl; and wherein R 1  is optionally substituted by one or two substituents each independently selected from the group consisting of halogen, C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 1 -C 6  alkyl-N(R N ) 2 , hydroxyl, C 1 -C 6  hydroxyalkyl, cyano, C 1 -C 6 cyanoalkyl, C(O)C 1 -C 6  alkyl, phenyl, benzyl, CH 2 \u2014(C 3 -C 6  cycloalkyl), 5 to 6 membered heteroaryl, and CH 2 -(5 to 6 membered heteroaryl); \n n is 0, 1 or 2; \n each R 2  is independently selected from the group consisting of C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, and C 1 -C 6  haloalkyl; or two R 2  together with the nitrogen atom to which they are both attached form a 4-6 membered heterocyclic ring; \n the A ring and the B ring are fused to form a polycyclic ring system, wherein \n the A ring is a 5 membered heteroaromatic ring having as its only heteroatoms, either (i) two or three nitrogen atoms, (ii) one nitrogen atom and one oxygen atom, or (iii) one nitrogen atom and one sulfur atom; wherein the A ring is optionally substituted at a carbon atom by one substituent selected from the group consisting of fluoro, chloro, methyl, and trifluoromethyl; and \n the B ring is a 4 to 8 membered carbocyclic ring, or a 4 to 8 membered heterocyclic ring having 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur;\n p is 1 or 2, and q is 0 or 1; or p is 0, and q is 1; \n wherein when p is 1, R B1  is R 3a  and when p is 2, R B1  is independently R 3a  and R 3b  and each R 3a  and R 3b , when present, is independently selected from the group consisting of halogen, deutero, hydroxyl, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  thioalkyl, C 1 -C 6  alkyl-N(R 2 ) 2 , and cyano; wherein two C 1 -C 6  alkyl substituents may together form a bridged or spirocyclic ring; and wherein if a nitrogen atom in the B ring is substituted, the substituent is not halogen, cyano, or a C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy or C 1 -C 6  thioalkyl having an oxygen or sulfur atom directly bonded to the nitrogen atom; and \n wherein when q is 1, R B2  is R 4  and R 4  is selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  thioalkyl, C 1 -C 6  alkyl-N(R 2 ) 2 , phenyl, benzyl, CH 2 \u2014(C 3 -C 6  cycloalkyl), CH 2 CH 2 \u2014(C 3 -C 6  cycloalkyl), CH 2 -(4 to 6 membered heterocyclyl), CH 2 CH 2 -(4 to 6 membered heterocyclyl), 5 to 6 membered heteroaryl, and CH 2 -(5 to 6 membered heteroaryl);\n wherein when R 4  is phenyl, heteroaryl or benzyl the phenyl or heteroaryl ring is optionally substituted by 1 to 3 substituents selected from the group consisting of halogen, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 1 -C 4  alkoxy, C 1 -C 4  haloalkoxy, and cyano.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 97.0
- Lexical Diversity: 1.48571
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12845045', '13002487', '11060463', '13725407', '14533358']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8010593655614195
- 35 USC 102 Novelty (BERT): 0.5318771333471222
- Combined Prediction Score: 0.7741411423399898
- Mean Citation Score: 326.0833320000001
- Max Citation Score: 345.5191
- Similarity Product: 257.6204774376273

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test