PATENT CLAIM ANALYSIS

Application Number: 15935299
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["435", "440000"]

Abstract:
Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.

Claim (Index 44):
An isolated  Staphylococcus aureus  Cas9 (SaCas9) protein, comprising an amino acid sequence that has at least 90% sequence identity to SEQ ID NO:2, with mutations at N419A/R654A, Y211A/R654A, Y211A/Y212A, Y211AN230A, Y211A/R245A, Y212A/Y230A, Y212A/R245A, Y230A/R245A, W229A/R654A, Y211A/Y212A/Y230A, Y211A/Y212A/R245A, Y211A/Y212A/Y651A, Y211A/Y230A/R245A, Y211A/Y230A/Y651A, Y211A/R245A/Y651A, Y211A/R245A/R654A, Y211A/R245A/N419A, Y211A/N419A/R654A, Y212A/Y230A/R245A, Y212A/Y230A/Y651A, Y212A/R245A/Y651A, Y230A/R245A/Y651A, R245A/N419A/R654A, T392A/N419A/R654A,R245A/T392AN419A/R654A, Y211A/R245A/N419A/R654A, W229A/R245A/N419A/R654A, Y211A/R245A/T392A/N419A/R654A, or Y211A1W229A/R245A/N419A/R654A.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.27778
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15249756', '15369533', '15015947', '15935334', '15208228']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7260336403702291
- 35 USC 102 Novelty (BERT): 0.8619754521654439
- Combined Prediction Score: 0.7396278215497506
- Mean Citation Score: 1001.4406119999996
- Max Citation Score: 1382.5892
- Similarity Product: 1239.6151486752983

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test