PATENT CLAIM ANALYSIS

Application Number: 16103581
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "263220"]

Abstract:
Compounds having a structure according to formula (I) where R 1  and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

Claim (Index 1):
A compound having a structure according to formula (I) wherein\n Ar is \n R 1 \u2014 is (C 1 -C 5  alkyl)O, (C 1 -C 2  alkyl)O(CH 2 ) 2-3 O, (C 1 -C 5  alkyl)C(\u2550O)O, (C 1 -C 5  alkyl)NH, (C 1 -C 2  alkyl)O(CH 2 ) 2-3 NH, or (C 1 -C 5  alkyl)C(\u2550O)NH; R 2  is, independently for each occurrence thereof, H, C 1 -C 3  alkyl, halo, O(C 1 -C 3  alkyl), CN, or NO 2 ; and R 3  and R 4  are independently H; C 1 -C 6  alkyl; (CH 2 ) 2-4 OH; (CH 2 ) 2-4 O(C 1 -C 3  alkyl); (CH 2 ) 2-4 NH 2 ; (CH 2 ) 2-4 NH(C 1 -C 3  alkyl); (CH 2 ) 2-4 N(C 1 -C 3  alkyl) 2 ; (CH 2 ) 1-3 (aryl); (CH 2 ) 1-3 (heteroaryl); (CH 2 ) 2-4 (OCH 2 CH 2 ) 2-8 (CH 2 ) 2-4 NHBoc; wherein a CH 2  group in the cycloaliphatic ring may be replaced by O, S, NH, or N(C 1 -C 3  alkyl) and the cycloaliphatic ring may be substituted with C 1 -C 3  alkyl, OH, O(C 1 -C 3  alkyl), halo, (CH 2 ) 0-3 NH 2 , or (CH 2 ) 0-3 NH(C 1 -C 3  alkyl);\n or R 3  and R 4  combine with the nitrogen to which they are bonded to form a cyclic amine of the structure \n wherein a CH 2  group in the cycloaliphatic ring that is separated from the amine nitrogen by at least two CH 2  groups may be replaced by O, S, NH, or N(C 1 -C 3  alkyl) and the cyclic amine may be substituted with C 1 -C 3  alkyl, OH, O(C 1 -C 3  alkyl), halo, (CH 2 ) 0-3 NH 2 , or (CH 2 ) 0-3 NH(C 1 -C 3  alkyl).

Metadata:
- Claim Count in Document: 24.0
- Percentile: 96.0
- Lexical Diversity: 1.29167
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16103619', '16103210', '16103511', '16103601', '15789027']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.791201141839025
- 35 USC 102 Novelty (BERT): 0.5225602091244587
- Combined Prediction Score: 0.7643370485675683
- Mean Citation Score: 321.189046
- Max Citation Score: 337.1311
- Similarity Product: 312.4794919068039

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test