PATENT CLAIM ANALYSIS

Application Number: 16013019
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["548", "362100"]

Abstract:
The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

Claim (Index 27):
A compound of formula (I): wherein: Ar is a group selected from wherein: R1 is A, NR6R7, OR8, SO n R9, COR10, nitro, cyano or an optionally substituted group selected from C 3 -C 6  cycloalkyl and heteroaryl; R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, SO n R9, COR10, NR11R12, OR13 or an optionally substituted group selected from straight or branched C 1 -C 6  alkyl, straight or branched C 2 -C 6  alkenyl, straight or branched C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl and heterocyclyl wherein: A is a straight or branched C 1 -C 6  alkyl substituted with a group selected from an optionally substituted heterocyclyl, an optionally substituted heteroaryl, SO n R9, COR10, NR11R12 and OR13; R6 is hydrogen or an optionally substituted group selected from straight or branched C 1 -C 6  alkyl, straight or branched C 2 -C 6  alkenyl, straight or branched C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, heterocyclyl, aryl and heteroaryl; R7 is hydrogen, SO n R9, COR10, a substituted straight or branched C 1 -C 6  alkyl or an optionally substituted group selected from straight or branched C 2 -C 6  alkenyl, straight or branched C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, heterocyclyl, aryl and heteroaryl or R6 and R7, taken together with the nitrogen atom to which they are bound, may form an optionally substituted heterocyclyl group; R8 is hydrogen, A, COR10 or an optionally substituted group selected from straight or branched C 2 -C 6  alkenyl, straight or branched C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein A is as defined above; R9 is NR or an optionally substituted group selected from straight or branched C 1 -C 6  alkyl, straight or branched C 2 -C 6  alkenyl, straight or branched C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, heterocyclyl, aryl and heteroaryl; R10 is hydrogen, NR11R12, OR13 or an optionally substituted group selected from straight or branched C 1 -C 6  alkyl, straight or branched C 2 -C 6  alkenyl, straight or branched C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, heterocyclyl, aryl and heteroaryl; R11 and R12 are independently hydrogen, SO n R9, COR10 or an optionally substituted group selected from straight or branched C 1 -C 6  alkyl, straight or branched C 2 -C 6  alkenyl, straight or branched C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein R9 and R10 are as defined above, or R11 and R12, taken together with the nitrogen atom to which they are bound, may form an optionally substituted heterocyclyl group; R13 is hydrogen, COR10 or an optionally substituted group selected from straight or branched C 1 -C 6  alkyl, straight or branched C 2 -C 6  alkenyl, straight or branched C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein R10 is as defined above; n is 0,1 or 2; X is a bond or an optionally substituted group selected from straight or branched C 1 -C 6  alkyl, heterocycly and aryl; Y is a bond, oxygen, or an optionally substituted group selected from straight or branched C 1 -C 6  alkyl, straight or branched C 2 -C 6  alkenyl, straight or branched C 2 -C 6  alkynyl, heterocyclyl and aryl; Z is a bond, oxygen or an optionally substituted straight or branched C 1 -C 6  alkyl; Ar\u2032 is an optionally substituted aryl or an optionally substituted heteroaryl; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 94.0
- Lexical Diversity: 1.47727
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15203087', '15203092', '12520387', '13140208', '12668745']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7844219219237851
- 35 USC 102 Novelty (BERT): 0.5945354072574301
- Combined Prediction Score: 0.7654332704571497
- Mean Citation Score: 462.263366
- Max Citation Score: 502.09686
- Similarity Product: 457.6807890007639

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test