PATENT CLAIM ANALYSIS

Application Number: 15914293
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "489000"]

Abstract:
The present invention provides oxygenized nanobubbles and their uses in imaging and cancer treatment when combined with therapeutic drugs and precise ultrasound beam steering.

Claim (Index 1):
A method of using synthesized oxygen nanobubbles to observe intracellular dynamics of a single cell or single tissue, comprising:\n a. Providing synthesized oxygen nanobubbles (ONBs) each consisting of a gaseous molecular oxygen core surrounded by a cellulosic polymer shell, wherein said core-shell structure generates non-uniformity of refractive index to force light to deviate from its linear trajectory to generate light scattering; b. Incubating said synthesized ONBs with target cells or tissue for a period of time; and c. Applying hyperspectral dark field microscopy to obtain precise location of said synthesized nanobubble within said cells or tissue, wherein said location is determined by (i) reconstructing hyperspectral image at a specific wavelength with signal normalization and setting of spectral filter and intensity threshold; and (ii) locating the position in the reconstructed image and extracting the spectrum from hyperspectral data.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 90.0
- Lexical Diversity: 1.08696
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14873208', '15691407', '13825941', '14349304', '14692075']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6870209243650461
- 35 USC 102 Novelty (BERT): 0.5280486855681662
- Combined Prediction Score: 0.6711237004853582
- Mean Citation Score: 236.782298
- Max Citation Score: 340.6913
- Similarity Product: 218.80848024276497

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test