PATENT CLAIM ANALYSIS

Application Number: 15917502
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["424", "186100"]

Abstract:
Disclosed are vaccine-derived neutralizing antibodies (NAbs) for CMV infections and small peptides which define precise recognition elements of the antigens by the NAbs. In certain embodiments, vaccine-derived NAbs may be produced by immunizing a subject with a gH/gL/UL128/UL130/UL131A pentameric glycoprotein complex (gH/gL-PC). In certain embodiments, vaccine-derived NAbs may have properties similar or identical to those of NAbs induced in a subject naturally infected with CMV. Native and non-native small peptides from UL128 and gH have been defined by mapping epitopes and deriving artificial sequences which are minimal recognition elements of vaccine-derived NAbs disclosed herein. These small peptides can be used to elicit vaccine-derived NAbs that prevent CMV entry into susceptible cell types and protect humans from infection and disease. Multivalent vaccines comprising these small peptides and/or epitopes are also disclosed. Kits and methods of using the vaccine-derived NAbs and small peptides disclosed herein including methods of treating or preventing CMV infection in a subject are also provided.

Claim (Index 4):
The vaccine-derived NAb of  claim 1 , wherein the vaccine-derived NAb has a positive correlation between neutralizing potency and binding affinity of one or more cell surface subunits of the pentameric complex.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.80851
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14606973', '15674569', '14973409', '15284799', '15156786']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8142311956010587
- 35 USC 102 Novelty (BERT): 0.5772233631631022
- Combined Prediction Score: 0.7905304123572631
- Mean Citation Score: 508.006204
- Max Citation Score: 571.97473
- Similarity Product: 355.10435562386635

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test