PATENT CLAIM ANALYSIS

Application Number: 16041821
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["424", "489000"]

Abstract:
Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with a taxane, such as, paclitaxel and derivatives thereof, which are water insoluble or poorly water soluble. The aggregates are formed by interaction of a taxane and a homopolymer. Such aggregates improve drug solubility, stability, delivery and efficacy.

Claim (Index 1):
An aggregate comprising:\n a) a polyoxazoline comprising at least one first terminal group modified with a hydrophobic moiety, wherein said polyoxazoline further comprises a linear portion, a branched portion or both, said branched portion comprises a symmetrically branched polymer, an asymmetrically branched polymer or a combination thereof; and said polyoxazoline comprises a molar ratio of monomer to initiator in a range of from 50:1 to 80:1, and b) a taxane, wherein said aggregate comprises a weight ratio of polymer to taxane of 6:1 to 8:1; is from about 50 nm to about 100 nm in size; and comprises a filtration rate through a 0.22 \u03bcm filter of from 50 to 100%.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.3913
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15818742', '15352521', '12833991', '12833988', '12834029']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7481165867123876
- 35 USC 102 Novelty (BERT): 0.569564696515042
- Combined Prediction Score: 0.7302613976926531
- Mean Citation Score: 338.446586
- Max Citation Score: 501.72864
- Similarity Product: 359.30503348686216

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test