PATENT CLAIM ANALYSIS

Application Number: 15910322
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "04400A"]

Abstract:
A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.

Claim (Index 1):
A composition, comprising an effective amount of a therapeutic agent encapsulated by a milk-derived microvesicle, wherein the therapeutic agent is a chemotherapeutic agent selected from platinum coordination compounds, taxane compounds, topoisomerase I inhibitors, topoisomerase II inhibitors, camptothecin compounds, anti-tumor podophyllotoxin derivatives, anti-tumor  vinca  alkaloids, anti-tumor nucleoside derivatives, alkylating agents, anti-tumor anthracycline derivatives, HER2 antibodies, selective estrogen receptor modulators, aromatase inhibitors, differentiating agents, retinoic acid metabolism blocking agents (RAMBA), DNA methyl transferase inhibitors, kinase inhibitors, farnesyltransferase inhibitors, HDAC inhibitors, inhibitors of the ubiquitin-proteasome pathway and combinations thereof.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 90.0
- Lexical Diversity: 1.5493
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14770634', '14825957', '14438172', '15458552', '15257669']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7655725461244456
- 35 USC 102 Novelty (BERT): 0.643367828244624
- Combined Prediction Score: 0.7533520743364635
- Mean Citation Score: 393.542248
- Max Citation Score: 777.15063
- Similarity Product: 552.5650958340132

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test