PATENT CLAIM ANALYSIS

Application Number: 15990176
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["800", "008000"]

Abstract:
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.

Claim (Index 2):
A method of generating a non-human homozygous transgenic organism, wherein the transgene does not comprise a reporter or selectable marker at a selected target locus, the method comprising,\n (a) introducing a reporter or selectable marker sequence into a cell of the organism using a nuclease that mediates targeted integration of the reporter into the selected target locus of the genome, the selected target locus comprising at least first and second alleles; (b) introducing the one or more transgene(s) into the cell, wherein the nuclease mediates targeted integration of the exogenous sequence into the selected target locus of the genome, wherein the one or more transgenes do not encode a selectable marker; (c) identifying cells comprising (i) the reporter or selectable marker in the first allele of the selected target locus and (ii) the one or more transgenes in the second allele; (d) allowing the cells identified in step (c) to develop to reproductively mature organisms; (e) crossing the reproductively mature organisms to each other and; (f) identifying progeny of the cross of step (e) that comprise the one or more transgenes in the first and second alleles, thereby generating an organism that is homozygous for the transgenes and lacking reporter or selectable marker sequences at the selected target locus.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 93.0
- Lexical Diversity: 1.15385
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13234007', '13794199', '12284887', '14807183', '15935908']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6340716881518312
- 35 USC 102 Novelty (BERT): 0.5090360075671899
- Combined Prediction Score: 0.621568120093367
- Mean Citation Score: 316.629834
- Max Citation Score: 327.7687
- Similarity Product: 245.89740355598929

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test