PATENT CLAIM ANALYSIS

Application Number: 15886014
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "252000"]

Abstract:
The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Claim (Index 1):
A compound of formula I: or a pharmaceutically acceptable salt, wherein X is CR 9 , or N; R 1  is C 1-8 alkyl, CN, C(O)OR 4  or CONR 5 R 6 , a 5-14 membered heteroaryl group, or a 3-14 membered cycloheteroalkyl group; R 2  is C 1-8 alkyl, C 3-14 cycloalkyl, or a 5-14 membered heteroaryl group, and wherein R 2  may be substituted with one or more C 1-8 alkyl, or OH; L is a bond, C 1-8 alkylene, C(O), or C(O)NR 10 , and wherein L may be substituted or unsubstituted; Y is H, R 11 , NR 12 R 13 , OH, or Y is part of the following group where Y is CR 9  or N;\n where 0-3 R 8  may be present, and R 8  is C 1-8 alkyl, oxo, halogen, or two or more R 8  may form a bridged alkyl group; \n W is CR 9 , or N; \n R 3  is H, C 1-8 alkyl, C 1-8 alkylR 14 , C 3-14 cycloalkyl, C(O)C 1-8  alkyl, C 1-8 haloalkyl, C 1-8 alkylOH, C(O)NR 14 R 15 , C 1-8 cyanoalkyl, C(O)R 14 , C 0-8 alkylC(O)C 0-8 alkylNR 14 R 15 , C 0-8 alkylC(O)OR 14 , NR 14 R 15 , SO 2 C 1-8 alkyl, C 1-8 alkylC 3-14 cycloalkyl, C(O)C 1-8 alkylC 3-14 cycloalkyl, C 1-8 alkoxy, or OH which may be substituted or unsubstituted when R 3  is not H. \n R 9  is H or halogen; \n R 4 , R 5 , R 6 , R 7 , R 10 , R 11 , R 12 , R 13 , R 14 , and R 15  are each independently selected from H, C 1-8 alkyl, C 3-14  cycloalkyl, a 3-14 membered cycloheteroalkyl group, a C 6-14  aryl group, a 5-14 membered heteroaryl group, alkoxy, C(O)H, C(N)OH, C(N)OCH 3 , C(O)C 1-3 alkyl, C 1-8 alkylNH 2 , C 1-6  alkylOH, and wherein R 4 , R 5 , R 6 , R 7 , R 10 , R 11 , R 12 , and R 13 , R 14 , and R 15  when not H may be substituted or unsubstituted; \n m and n are independently 0-2; and \n Wherein L, R 3 , R 4 , R 5 , R 6 , R 7 , R 10 , R 11 , R 12 , and R 13 , R 14 , and R 15  may be substituted with one or more of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-14 cycloalkyl, 5-14 membered heteroaryl group, C 6-14 aryl group, a 3-14 membered cycloheteroalkyl group, OH, (O), CN, alkoxy, halogen, or NH 2 .

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.53704
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13060154', '14158358', '12545322', '13579359', '13786955']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8162887798472309
- 35 USC 102 Novelty (BERT): 0.6088872418227655
- Combined Prediction Score: 0.7955486260447844
- Mean Citation Score: 489.78964
- Max Citation Score: 549.5182
- Similarity Product: 470.9580234334826

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test