PATENT CLAIM ANALYSIS

Application Number: 15764687
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["514", "480000"]

Abstract:
Provided herein are methods that relate to a therapeutic strategy for treatment of cancer, and allergic, autoimmune, and inflammatory disorders including hematological malignancies. In particular, the methods include administration of a BTK inhibitor and with one or more inhibitor. For example, the one or more inhibitor may be a JAK inhibitor, a ASK1 inhibitor, a BRD4 inhibitor or an MMP9 inhibitor.

Claim (Index 9):
The method of  claims 1  or  6  wherein the modulator of the bromodomain-containing protein is a compound of Formula II: wherein R 1a  and R 1b  are each independently C 1-6  alkyl optionally substituted with from 1 to 5 R 20  groups; R 2a  and R 2b  are each independently H or halo; R 3  is \u2014C(O)OR a , \u2014NHC(O)OR a , \u2014NHS(O) 2 R a , or \u2014S(O) 2 NR a R b ; or selected from the group consisting of C 1-10  alkyl, C 1-10  alkoxy, amino, C 5-10  aryl, C 6-20  arylalkyl, C 1-10  heteroalkyl, C 5-10  heteroaryl, and C 6-20  heteroarylalkyl, each of which is optionally substituted with from 1 to 5 R20 groups; one of R 4a  and R 4b  is selected from the group consisting of H and C 1-6  alkyl optionally substituted with from 1 to 5 R 20  groups, and the other is absent; R 5  is \u2014C(O)OR a , \u2014NHC(O)OR a , \u2014NHS(O) 2 R a , or \u2014S(O) 2 NR a R b ; or R 5  is selected from the group consisting of H, C 1-10  alkyl, C 1-10  haloalkyl, C 1-10  alkoxy, amino, C 5-10  aryl, C 6-20  arylalkyl, C 1-10  heteroalkyl, C 5-10  heteroaryl, and C 6-20  heteroarylalkyl, each of which is optionally substituted with from 1 to 5 R 20  groups; each R a  and R b  is independently selected from the group consisting of H, C 1-10  alkyl, C 5-10  aryl, C 6-20  arylalkyl, C 1-10  heteroalkyl, C 5-10  heteroaryl, and C 6-20  heteroarylalkyl, each of which is optionally substituted with from 1 to 5 R 20  groups; and each R20 is independently selected from the group consisting of acyl, C 1-10  alkyl, C 1-10  alkoxy, amino, amido, amidino, C 5-10  aryl, C 6-20  arylalkyl, azido, carbamoyl, carboxyl, carboxyl ester, cyano, guanidino, halo, C 1-10  haloalkyl, C 1-10  heteroalkyl, C 5-10  heteroaryl, C 6-20  heteroarylalkyl, hydroxy, hydrazino, imino, oxo, nitro, sulfinyl, sulfonic acid, sulfonyl, thiocyanate, thiol, and thione; and wherein the C 1-10  alkyl, C 5-10  aryl, C 6-20  arylalkyl, C 1-10  heteroalkyl, C 5-10  heteroaryl, and C 6-20  heteroarylalkyl groups are optionally substituted with from 1 to 3 substituents independently selected from C 1-6  alkyl, C 5-10  aryl, halo, C 1-6  haloalkyl, cyano, hydroxy, and C 1-6  alkoxy; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.61364
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15319740', '14135812', '15105372', '14254010', '14570655']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8030043995415567
- 35 USC 102 Novelty (BERT): 0.4938513640849913
- Combined Prediction Score: 0.7720890959959001
- Mean Citation Score: 247.382998
- Max Citation Score: 260.51425
- Similarity Product: 213.13904621295632

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test