PATENT CLAIM ANALYSIS

Application Number: 15860506
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "186100"]

Abstract:
Methods for determining the susceptibility or resistance of bacteria to antibiotic agents are provided. In one embodiment, the methods include culturing the bacteria in the presence or absence or the antimicrobial agent to generate a primary culture which is then cultured in the presence or absence of transforming phages. The recombinant phages are specific to the bacteria and comprise a heterologous marker (e.g., a nucleic acid that is expressible as a detectable product such as an RNA or a protein). The susceptibility or resistance of the bacteria to the antimicrobial agent may be determined by assaying the culture for the presence or absence of the heterologous marker, wherein a reduction in the level or activity of the marker in the culture compared to the level or activity of the marker in a comparative culture indicates that the bacteria is sensitive to the antibiotic agent.

Claim (Index 13):
A method for simultaneous identification of a bacteria species in a sample and determination of its susceptibility to an antimicrobial agent, comprising:\n (a) culturing aliquots of a sample with and without an antimicrobial agent to generate a set of primary cultures; (b) culturing portions of the set of primary cultures with and without a transforming phage specific to a bacteria species and which is engineered to express a heterologous marker, thereby generating a plurality of transformed secondary cultures, wherein a first transformed secondary culture comprises transformed bacteria cultured with antimicrobial agent and a second transformed secondary culture comprises transformed bacteria not cultured with the antimicrobial agent; and (c) detecting presence or absence of the heterologous marker, where presence of the marker indicates presence of the bacteria species in the sample and its resistance to the antimicrobial agent.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 86.0
- Lexical Diversity: 2.15493
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12812212', '09600398', '14119716', '13224776', '15161857']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7300405164814967
- 35 USC 102 Novelty (BERT): 0.4839640726588489
- Combined Prediction Score: 0.705432872099232
- Mean Citation Score: 216.71058
- Max Citation Score: 220.99445
- Similarity Product: 173.36400836747882

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test