PATENT CLAIM ANALYSIS

Application Number: 15571475
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["514", "330000"]

Abstract:
Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.

Claim (Index 98):
A method of reducing the level of a K-Ras protein, said method comprising contacting the K-Ras protein with a compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the formula: wherein, Y is N or CH Ring A is a C 3 -C 7  cycloalkyl or 3 to 7 membered heterocycloalkyl; R 1  is independently halogen, CX 1 3 , \u2014CHX 1 2 , \u2014CH 2 X 1 , \u2014CN, \u2014SO 2 Cl, \u2014SO n1 R 10 , \u2014SO v1 NR 7 R 8 , \u2014NHNR 7 R 8 , \u2014ONR 7 R 8 , \u2014NHC\u2550(O)NHNR 7 R 8 , \u2014NHC(O)NR 7 R 8 , \u2014N(O) m1 , \u2014NR 7 R 8 , \u2014C(O)R 9 , \u2014C(O)\u2014OR 9 , \u2014C(O)NR 7 R 8 , \u2014OR 10 , \u2014NR 7 SO 2 R 10 , \u2014NR\u2032C(O)R 9 , \u2014NR\u2032C(O)OR 9 , \u2014NR 7 OR 9 , \u2014OCX 1 3 , \u2014OCHX 1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; two adjacent R 1  substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L 1  is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene; L 2  is a bond, \u2014O\u2014, \u2014C(O)\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014S(O) 2 \u2014, \u2014NR 7B \u2014, \u2014NR 7B C(O)\u2014, \u2014C(O)NR 7B \u2014, \u2014SO 2 NR 7B \u2014, \u2014NR 7B SO 2 \u2014, \u2014OC(O)NR 7B \u2014, \u2014NR 7B C(O)O\u2014, \u2014CR 9B \u2550NO\u2014, \u2014ON\u2550CR 9B \u2014, \u2014NR 8B C(O)NR 7B \u2014, \u2014NR 8B C(\u2550NR 10B ) NR 7B , \u2014NR 8B C(\u2550NR 10B )\u2014, \u2014C(\u2550NR 10B )NR 7B \u2014, \u2014OC(\u2550NR 10B )\u2014, \u2014C(\u2550NR 10B )O\u2014, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene; L 4  is a bond, \u2014O\u2014, \u2014C(O)\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014S(O) 2 \u2014, \u2014NR 4 \u2014, \u2014NR 4 C(O)\u2014, \u2014C(O)NR 4 \u2014, \u2014SO 2 NR 4 \u2014, \u2014NR 4 SO 2 \u2014, \u2014NR 4 SO 2 \u2014, \u2014OC(O)NR 4 \u2014, \u2014NR 4 C(O)O\u2014, substituted or unsubstituted C 1 -C 3  alkylene, substituted or unsubstituted 2 to 3 membered heteroalkylene; E is an electrophilic moiety; R 2  is independently oxo, halogen, CX 2 3 , \u2014CHX 2 2 , \u2014CH 2 X 2 , \u2014CN, \u2014SO 2 Cl, \u2014SO n2 R 14 , \u2014SO v2 NR 11 R 12 , \u2014NHNR 11 R 12 , \u2014ONR 11 R 12 , \u2014NHC\u2550(O)NHNR 11 R 12 , \u2014NHC(O)NR 11 R 12 , \u2014N(O) m2 , \u2014NR 11 R 12 , \u2014C(O)R 14 , \u2014C(O)\u2014OR 14 , \u2014C(O)NR 11 R 12 , \u2014OR 15 , \u2014NR 11 SO 2 R 15 , \u2014NR 11 C(O)R 14 , \u2014NR 11 C(O)OR 14 , \u2014NR 11 OR 14 , \u2014OCX 2 3 , \u2014OCHX 2 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; two adjacent R 2  substituents or two R 2  substituents bonded to the same atom may optionally be joined to form a substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl; R 4  is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; R 7 , R 8 , R 9 , R 10 , R 7B , R 8B , R 9B , R 10B , R 11 , R 12 , R 14 , and R 15  are independently hydrogen, halogen, \u2014CX 3 , \u2014CN, \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 2 Cl, \u2014SO 3 H, \u2014SO 4 H, \u2014SO 2 NH 2 , \u2014NHNH 2 , \u2014ONH 2 , \u2014NHC(O)NHNH 2 , \u2014NHC(O)NH 2 , \u2014NHSO 2 H, \u2014NHC(O)H, \u2014NHC(O)OH, \u2014NHOH, \u2014OCX 3 , \u2014OCHX 2 , \u2014CHX 2 , \u2014CH 2 X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 7  and R 8  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R 11  and R 12  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; each X, X 1 , and X 2  is independently \u2014F, \u2014Cl, \u2014Br, or \u2014I; n1, n2, v1, and v2 are independently an integer from 0 to 4; m1 and m2 are independently an integer from 1 to 2; z1 is independently an integer from 0 to 5; and z2 is independently an integer from 0 to 10.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 93.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15382942', '15950953', '15757238', '15662861', '15700040']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8467236455016177
- 35 USC 102 Novelty (BERT): 0.5813477630331935
- Combined Prediction Score: 0.8201860572547752
- Mean Citation Score: 535.581868
- Max Citation Score: 593.351
- Similarity Product: 384.97062950938937

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test