PATENT CLAIM ANALYSIS

Application Number: 16156447
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-08
Patent Classification: ["514", "287000"]

Abstract:
The invention relates to compound of the formula (I′) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

Claim (Index 10):
A method of suppressing the effect of nonsense mutations in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound of Formula (Ia\u2032) or a pharmaceutically acceptable salt thereof, wherein: R 1  is selected from a five- to seven-membered monocyclic saturated or unsaturated non-aromatic ring system, wherein said ring system may contain from 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and wherein said ring system may be substituted once or more than once by R 6 ; pyrrolyl; pyrazolyl; thiophenyl; and pyridin-2-yl; and wherein the phenyl ring is attached via the bond marked with an asterisk (*), and wherein the pyrrolyl, pyrazolyl, thiophenyl, and pyridin-2-yl may be substituted by C 1-3 alkyl;\n wherein when R 1  is a five- to seven-membered monocyclic saturated or unsaturated non-aromatic ring system, then R 2  is selected from C 2-6 alkyl which may be substituted once or more than once by R 7 ; \u2014X 1 \u2014R 8 ; and a three- to seven-membered monocyclic aromatic, saturated or unsaturated non-aromatic ring system, wherein said ring system may contain from 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and wherein said ring system may be substituted once or more than once by R 11 ; \n or wherein when R 1  is pyrrolyl, pyrazolyl, thiophenyl, pyridin-2-yl, or phenyl, then R 2  is selected from C 2-7 alkyl which may be substituted once or more than once by R 13 ; \u2014X 2 \u2014R 14 ; and a three- to seven-membered monocyclic saturated or unsaturated non-aromatic ring system, wherein said ring system may contain from 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and wherein said ring system may be substituted once or more than once by R 17 ; \n X 1 \u2014 is \u2014O\u2014, \u2014S\u2014 or \u2014N(R 9 )\u2014; \n X 2 \u2014 is \u2014O\u2014, \u2014S\u2014 or \u2014N(R 15 )\u2014; \n R 3  is hydrogen or \u2014CH 2 R 18 ; \n R 8  is C 1-6 alkyl which may be substituted once or more than once by R 10 ; \n R 9  is hydrogen or C 1-4 alkyl; \n each R 12  independently is hydrogen, halogen, hydroxyl, amino, cyano, nitro, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy-C 1-4 alkyl, amino-C 1-4 alkyl, C 1-4 alkyl-amino-C 1-4 alkyl, di(C 1-4 alkyl)-amino-C 1-4 alkyl, C 1-4 alkoxy, C 1-4 halogenalkoxy, C 1-4 alkylamino or di(C 1-4 alkyl)amino; or C 3-6 cycloalkyl, wherein one carbon atom may be replaced by an oxygen atom, wherein the C 3-6 cycloalkyl may be attached directly or via a C 1-2 alkylene, and wherein the C 3-6 cycloalkyl may be substituted once or more than once by halogen; \n R 14  is C 1-6 alkyl which may be substituted once or more than once by R 16 ; \n R 15  is hydrogen or C 1-4 alkyl; \n R 18  is hydrogen, C 1-4 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, C 1-3 alkoxyC 1-3 alkyl, hydroxyC 1-3 alkyl, or aminoC 1-3 alkyl; \n R 21  is hydrogen, halogen, hydroxyl, amino, cyano, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy-C 1-4 alkyl, amino-C 1-4 alkyl, C 1-4 alkyl-amino-C 1-4 alkyl, di(C 1-4 alkyl)-amino-C 1-4 alkyl, C 1-4 alkoxy, C 1-4 halogenalkoxy, C 1-4 alkylamino, di(C 1-4 alkyl)amino; or a three- to seven-membered monocyclic aromatic, saturated or unsaturated non-aromatic ring system, wherein said ring system may contain from 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein said ring system may be attached directly or via a C 1-2 alkylene, and wherein said ring system may be substituted once or more than once by R 23 ; \n R 22  is hydrogen, halogen, hydroxyl, cyano, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy-C 1-4 alkyl, amino-C 1-4 alkyl, C 1-4 alkyl-amino-C 1-4 alkyl, di(C 1-4 alkyl)-amino-C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkinyl, C 1-4 alkoxy, C 1-4 halogenalkoxy, or C 3-4 cycloalkyl, wherein one carbon atom of the C 3-4 cycloalkyl may be replaced by an oxygen atom, wherein the C 3-4 cycloalkyl may be attached directly or via a C 1-2 alkylene, and wherein the C 3-4 cycloalkyl may be substituted once or more than once by halogen; \n R 6 , R 11 , R 17 , and R 23  each independently is halogen, hydroxyl, amino, cyano, nitro, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy-C 1-4 alkyl, amino-C 1-4 alkyl, C 1-4 alkyl-amino-C 1-4 alkyl, di(C 1-4 alkyl)-amino-C 1-4 alkyl, C 1-4 alkoxy, C 1-4 halogenalkoxy, C 1-4 alkylamino, di(C 1-4 alkyl)amino, or C 3-6 cycloalkyl, wherein one carbon atom of the C 3-6 cycloalkyl may be replaced by an oxygen atom, wherein the C 3-6 cycloalkyl may be attached directly or via a C 1-2 alkylene, and wherein the C 3-6 cycloalkyl may be substituted once or more than once by halogen; \n or two R 6 , R 11 , R 17 , and R 23  at the same ring atom together are oxo; \n or two R 6 , R 11 , R 17 , and R 23  at the same ring carbon atom together with said carbon atom form a C 3-6 cycloalkyl; \n R 7 , R 10 , R 13 , and R 16  each independently is halogen, hydroxyl, amino, cyano, nitro, C 1-4 alkoxy, C 1-4 halogenalkoxy, C 1-4 alkylamino, di(C 1-4 alkyl)amino, or C 3-6 cycloalkyl, wherein one carbon atom of the C 3-6 cycloalkyl may be replaced by an oxygen atom, wherein the C 3-6 cycloalkyl may be attached directly or via a C 1-2 alkylene, and wherein the C 3-6 cycloalkyl may be substituted once or more than once by halogen; \n or two R 7 , R 10 , R 13 , or R 16  at the same carbon atom together are oxo; \n or two R 7 , R 10 , R 13 , or R 16  at the same carbon atom together with said carbon atom form a C 3-6 cycloalkyl; and \n R 24  is hydrogen or halogen.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 97.0
- Lexical Diversity: 1.24242
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14728613', '14652102', '15554801', '15315582', '14763468']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7138950442455129
- 35 USC 102 Novelty (BERT): 0.6450734521038143
- Combined Prediction Score: 0.7070128850313431
- Mean Citation Score: 382.642246
- Max Citation Score: 668.1334
- Similarity Product: 547.1068360653281

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test