PATENT CLAIM ANALYSIS

Application Number: 16046696
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "241000"]

Abstract:
Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.

Claim (Index 5):
The method of  claim 1  wherein the bacterial efflux pump inhibitor is a compound of formula V: or a pharmaceutically acceptable salt thereof, wherein: A\u2033 is \u2014C(\u2550O)N(R a1 )\u2014R 1D , \u2014(C 1 -C 3 )alkyl-C(\u2550O)N(R a1 )R 1D , \u2014(C 1 -C 3 )alkyl-O\u2014R 1D , \u2014O\u2014R 1D , \u2014(C 1 -C 3 )alkyl-N(R a1 )\u2014R 1D , \u2014N(R a1 )\u2014R 1D , or R 1D ; B\u2033 is (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 3 -C 7 )carbocyclyl, (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl-, aryl, aryl-(C 1 -C 4 )alkyl-, heteroaryl, heteroaryl-(C 1 -C 4 )alkyl-, 3-7 membered-monocyclic-heterocycle, or 3-7 membered-monocyclic-heterocycle-(C 1 -C 4 )alkyl- wherein any (C 3 -C 7 )carbocyclyl, (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl-, aryl, aryl-(C 1 -C 4 )alkyl-, heteroaryl, heteroaryl-(C 1 -C 4 )alkyl-, 3-7 membered-monocyclic-heterocycle, or 3-7 membered-monocyclic-heterocycle-(C 1 -C 4 )alkyl- of B\u2033 is optionally substituted with one or more Z 1  groups; each R 1D  is independently: (a) (C 1 -C 14 )alkyl substituted with one or more groups selected from the group consisting of \u2014NR b2 R c2 , \u2014NHN 2 , \u2014C(\u2550NR a2 )(NR b2 R c2 ), \u2014NR a2 C(\u2550NR a2 )(R d2 ), and \u2014NR a2 C(\u2550NR a2 )(NR b2 R c2 ) and wherein (C 1 -C 14 )alkyl is optionally substituted independently with one or more halo, (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; or (b) (C 3 -C 7 )carbocyclyl, (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl-, 4-7 membered monocyclic heterocyclyl, or 4-7 membered monocyclic heterocyclyl-(C 1 -C 4 )alkyl-, wherein each (C 3 -C 7 )carbocyclyl or (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl- is independently substituted with one or more Z 2  or Z 3 , and wherein each 4-7 membered monocyclic heterocyclyl or 4-7 membered monocyclic heterocyclyl-(C 1 -C 4 )alkyl- is independently optionally substituted with one or more Z 2  or Z 3 , and wherein any (C 3 -C 7 )carbocyclyl, (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl-, 4-7 membered monocyclic heterocyclyl, or 4-7 membered monocyclic heterocyclyl-(C 1 -C 4 )alkyl- of R 1  is optionally substituted independently with one or more halo, (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; R 2D  is hydrogen, (C 1 -C 4 )alkyl or phenyl(C 1 -C 3 )alkyl-, wherein the phenyl is optionally substituted with one or more (C 1 -C 4 )alkyl, \u2014O(C 1 -C 4 )alkyl, halogen, or \u2014NO 2 ; R 3D  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl, or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, \u2014OH, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, and (C 1 -C 4 )haloalkoxy; R 4D  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl, or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, \u2014OH, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, and (C 1 -C 4 )haloalkoxy; R 5D  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl, or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, \u2014OH, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, and (C 1 -C 4 )haloalkoxy; R 6D  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl, or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, \u2014OH, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, and (C 1 -C 4 )haloalkoxy; each Z 1  is independently halo, \u2014OH, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, or (C 1 -C 4 )haloalkoxy; each Z 2  is independently selected from the group consisting of \u2014NR b3 R c3 , \u2014NHNH 2 , \u2014C(\u2550NR a3 )(NR b3 R d3 ), \u2014NR a3 C(\u2550NR a3 )(R d3 ), and \u2014NR a3 C(\u2550NR a3 )(NR b3 R c3 ) each Z 3  is independently \u2014(C 1 -C 6 )alkyl substituted with one or more Z 2  and optionally substituted with one or more Z 4 ; each Z 4  is independently halo or (C 3 -C 7 )carbocyclyl; each R a1  is independently hydrogen, (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; each R a2  is independently hydrogen, (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; each R b2  and R c2  is independently hydrogen, (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; R d2  is (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; each R a3  is independently hydrogen (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; each R b3  and R 3  is independently hydrogen (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; and R d3  is (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl.

Metadata:
- Claim Count in Document: 25.0
- Percentile: 95.0
- Lexical Diversity: 1.75
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15066911', '15323081', '15296601', '11791928', '13066616']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.831794863744788
- 35 USC 102 Novelty (BERT): 0.5463768436201498
- Combined Prediction Score: 0.8032530617323241
- Mean Citation Score: 388.26477400000016
- Max Citation Score: 418.62888
- Similarity Product: 292.13990975461013

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test