PATENT CLAIM ANALYSIS

Application Number: 16063297
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "619000"]

Abstract:
The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R 1  is —OH, R 2  is —NO 2  and R 3  is H, R 4  and R 5  are H, one of R 6  and R 7  is selected from H, —CONH 2 , and —CONR 9 2 , and the other one is selected from —CONR 9 2  and —CONR 11 R 9 , wherein R 9  and R 11  are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.

Claim (Index 11):
The compound of  claim 1 , wherein R 7  is \u2014CONR 9 R 11 , wherein\n R 9  is (CH 2 ) 4 \u2014(Y\u2014R 10 ) n , Y is selected from \u2014CONR 11 \u2014, \u2014NR 11 CO\u2014, \u2014NR 11 COO\u2014, and \u2014NR 11 CONR 11 \u2014, n is 1 or 2, R 10  is an unsubstituted or monosubstituted C 1 \u2014, C 2 \u2014, C 3 - or C 4  alkyl, R 11  is an unsubstituted methyl or ethyl.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 94.0
- Lexical Diversity: 1.98649
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['11202611', '15437618', '11948239', '13002475', '10621276']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7549320661014693
- 35 USC 102 Novelty (BERT): 0.4965235408763234
- Combined Prediction Score: 0.7290912135789548
- Mean Citation Score: 212.110892
- Max Citation Score: 218.88503
- Similarity Product: 162.86763546061218

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test