PATENT CLAIM ANALYSIS

Application Number: 16244900
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["549", "464000"]

Abstract:
The present invention provides a process for the preparation of darunavir or solvates or a pharmaceutically acceptable salt thereof substantially free of bisfuranyl impurities, particularly darunavir propionate solvate. The present invention also provides a process for preparation amorphous darunavir using the darunavir propionate solvate.

Claim (Index 54):
A method for the preparation of darunavir propionate solvate according to  claim 14  comprising:\n a) mixing an amount of 1-([[(3R,3aS,6aR)hexahydrofuro[2,3-b]furan-3-yloxy]-carbonyl]oxy)-2,5-pyrrolidinedione of Formula V, ethyl acetate, and water in a mixing vessel, \n b) adding to the reaction mass of step a) an amount of the compound of Formula II at 25\u00b0 C. to 30\u00b0 C., c) adding to the reaction mass of step b) an amount of aqueous potassium carbonate; d) separating the organic layer thus formed and washing the same with an amount of water; e) distilling from the organic layer obtained in step d) the ethyl acetate under vacuum to obtain a residue; f) mixing an amount of propionic acid with the residue obtained from step e) at 25\u00b0 C. to 30\u00b0 C. to form the darunavir propionate solvate; g) precipitating the darunavir propionate solvate from the mixture of step f) and dry the same under reduced pressure to obtain a solid.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 99.0
- Lexical Diversity: 1.62069
- Patent Class: 549.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15211525', '14415101', '13496642', '13261929', '15739948']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7809379342031044
- 35 USC 102 Novelty (BERT): 0.5527299502383753
- Combined Prediction Score: 0.7581171358066315
- Mean Citation Score: 383.220054
- Max Citation Score: 437.91107
- Similarity Product: 328.96003145148984

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test