PATENT CLAIM ANALYSIS

Application Number: 16039947
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["540", "500000"]

Abstract:
Compounds represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula, R 1 , R 2  and R 3  represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, and the like, X represents C or N, Y represents N or C(═O), provided that when X is C, Y represents N, and when X is N, Y represents C(═O), the double line consisting of the solid line and the broken line represents a single bond or double bond, n represents an integer of 0 to 6, Z represents O, S, or an atomic bond, and A represents benzene ring, pyridine ring, and the like).

Claim (Index 21):
The compound according to  claim 12 , a tautomer or a stereoisomer of the compound, or a pharmacologically acceptable salt thereof, selected from the group consisting of the following (1) to (13), (23) and (24):\n (1)\n N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]-3-(pyr idin-2-yl)propionamide; \n (2)\n 2-ethyl-3-hydroxy-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]benzamide; \n (3)\n 2-ethyl-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]nicotinamide dihydrochloride; \n (4)\n 2-ethyl-6-hydroxy-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]benzamide; \n (5)\n 3-ethyl-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]picolinamide hydrochloride; \n (6)\n -[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]-diazepin-5-yl)phenyl]-2-(pyridin-2-yloxy)acetamide hydrochloride; \n (7)\n 2-(2-methoxyphenyl)-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepi n-5 -yl)phenyl] acetamide; \n (8)\n N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepin-5-yl)-phenyl]-3-(pyr idin-3-yl)propionamide dihydrochloride; \n (9)\n N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepin-5-yl)phenyl]-3-phen ylpropanamide; \n (10)\n N-[4-(2,4-dioxo-3,4-dihydro-1H-naphtho[1,2-b][1,4]diazepin-5(2H)-yl)-pheny 1]-3-(pyridin-3-yl)propionamide hydrochloride; \n (11)\n N-[4-(2,4-dioxo-3,4-dihydro-1H-naphtho[1,2-b][1,4]diazepin-5(2H)-yl)-pheny 1]-3-(pyridin-4-yl)propionamide hydrochloride; \n (12)\n 2-tert-butyl-N-[4-(2,4-dioxo-3,4-dihydro-1H-naphtho [2,1 -b][1,4]diazepin-5 (2 H)-yl)2-fluorophenyl]benzamide; \n (13)\n N-[4-(2,4-dioxo-3,4-dihydro-1H-naphtho[1,2-b][1,4]diazepin-5(2H)-yl)-pheny 1]-3-(pyridin-2-yl)propionamide hydrochloride; \n (22)\n 4-(dimethylamino)-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepin-5(2H)-yl)phenyl]nicotinamide dihydrochloride; \n (23)\n 2-isopropyl-N-[4-(2-oxo-2,3-dihydro-1H-naphtho [1,2-e][1,4]diazepin-5(2H)-y Ophenyl]nicotinamide dihydrochloride; and \n (24)\n 2-(isopropylamino)-N-[4-(2-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,4]diazepin-5(2H)-yl)phenyl]nicotinamide dihydrochloride.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 95.0
- Lexical Diversity: 2.22857
- Patent Class: 540.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14903343', '15923685', '15176857', '14371868', '14903382']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7604190790181105
- 35 USC 102 Novelty (BERT): 0.592607326321158
- Combined Prediction Score: 0.7436379037484153
- Mean Citation Score: 449.1418019999999
- Max Citation Score: 515.3993
- Similarity Product: 420.8202762875736

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test