PATENT CLAIM ANALYSIS

Application Number: 16057954
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["424", "499000"]

Abstract:
Systems and methods for targeting specific cancer cell subpopulations present in tumor tissue are described. A system can include a first component for specifically targeting cancer stem cells and a second component for specifically targeting differentiated cancer cells. A system can include a drug conjugated to small (e.g., 5-20 nm) nanoparticles, e.g., polyhedral oligomeric silsequioxane nanoparticles. The small nanoparticles can be preferentially taken up by cancer stem cells via macropinocytosis and can release a toxic payload within the cancer stem cells without triggering the efflux pump. A system can include a second component that targets differentiated cancer cells, e.g., a free drug or a drug encapsulated in nanoparticles.

Claim (Index 19):
The method of  claim 15 , wherein the second biologically active agent is directly or indirectly conjugated to an antibody, the method further comprising directly or indirectly binding the second biologically active agent to the differentiated cancer cells via the antibody.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 96.0
- Lexical Diversity: 1.875
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15616103', '14527028', '13984411', '14408748', '14950033']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6838733556433034
- 35 USC 102 Novelty (BERT): 0.5144498941385676
- Combined Prediction Score: 0.6669310094928299
- Mean Citation Score: 248.608056
- Max Citation Score: 253.87616
- Similarity Product: 162.89814532711029

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test