PATENT CLAIM ANALYSIS

Application Number: 15876880
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-06
Patent Classification: ["546", "242000"]

Abstract:
We describe a bis-benzylidine piperidone, RA190, which covalently binds to the ubiquitin receptor RPN13 (ADRM1) in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins. Multiple myeloma lines, even those resistant to bortezomib, were sensitive to RA190 via ER stress-related apoptosis. RA190 stabilized targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially killed HPV-transformed cells. After p.o. or i.p. dosing of mice, RA190 distributed to plasma and major organs excepting brain, and potently inhibited proteasome function in skin and muscle. RA190 administration i.p. profoundly reduced growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment retarded HPV+ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8+ T cell responses, suggesting its therapeutic potential. The bis-benzylidine piperidone RA190 is a new orally-available proteasome inhibitor. Multiple myeloma, cervical and ovarian cancers are particularly sensitive to RA190.

Claim (Index 17):
The method of  claim 1 , wherein the compound has the structure:

Metadata:
- Claim Count in Document: 4.0
- Percentile: 86.0
- Lexical Diversity: 1.53211
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14889768', '13513819', '14933671', '12669361', '12527428']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7564394539338251
- 35 USC 102 Novelty (BERT): 0.6002519955947864
- Combined Prediction Score: 0.7408207080999212
- Mean Citation Score: 335.409252
- Max Citation Score: 581.3244
- Similarity Product: 423.4839157547235

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test