PATENT CLAIM ANALYSIS

Application Number: 16374482
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-07
Patent Classification: ["435", "455000"]

Abstract:
The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.

Claim (Index 10):
A method for reprogramming a differentiated cell to a less differentiated state, comprising:\n (a) providing a differentiated cell; (b) culturing the differentiated cell; and (c) transfecting the differentiated cell with one or more synthetic RNA molecules,\n wherein the one or more synthetic RNA molecules include at least one RNA molecule encoding one or more reprogramming factors; \n wherein the transfecting results in the cell expressing the one or more reprogramming factors; and \n wherein step (c) is performed at least twice and the amount of one or more synthetic RNA molecules transfected in one or more later transfections is greater than the amount transfected in one or more earlier transfections to result in the cell being reprogrammed to a less differentiated state and occurs in the presence of a medium containing ingredients that support reprogramming of the differentiated cell to a less differentiated state.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 100.0
- Lexical Diversity: 1.55172
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15947741', '16037597', '15358818', '15605513', '15178190']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.68113432771187
- 35 USC 102 Novelty (BERT): 0.6113333941327228
- Combined Prediction Score: 0.6741542343539553
- Mean Citation Score: 541.9451839999998
- Max Citation Score: 551.3385
- Similarity Product: 508.1619919542074

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test