PATENT CLAIM ANALYSIS

Application Number: 15925628
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "130100"]

Abstract:
Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. In several embodiments, the compositions are configured for clearance of a circulating protein or peptide or antibody associated with one or more of the above-mentioned maladies. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.

Claim (Index 1):
A compound comprising Formula 1: where:\n m is an integer from about 1 to 10; \n X comprises a protein or protein fragment comprising an antigenic region; \n Y is of a linker moiety having a formula selected from the group consisting of: \n wherein:\n the left bracket \u201c(\u201d indicates a bond to X; \n where present the right \u201c)\u201d indicates a bond to Z; \n where present the bottom \u201c)\u201d indicates a bond to Z; \n where present n is an integer from about 1 to about 80; \n where present q is an integer from about 1 to about 4; \n where present p is an integer from about 1 to about 90; \n where present R 8  is \u2014CH 2 \u2014 or \u2014CH 2 \u2014CH 2 \u2014C(CH 3 )(CN)\u2014; and \n where present W represents a polymer of the Formula W 1  or W 2  group or\n W is a copolymer of Formula W 1  or W 2  where: \n \n where:\n R 9  is a direct bond, \u2014CH 2 \u2014CH 2 \u2014NH\u2014C(O)\u2014 or \u2014CH 2 \u2014CH 2 \u2014(O\u2014CH 2 \u2014CH 2 ) t \u2014NH\u2014C(O)\u2014; \n t is an integer from 1 to 5; \n R 10  is an aliphatic group, an alcohol or an aliphatic alcohol; and \n Z comprises one or more liver-targeting moieties selected from the group consisting of glucose, glucosamine, and N-acetylglucosamine.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 90.0
- Lexical Diversity: 1.86885
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15185564', '14649902', '12684685', '12993855', '14417487']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6593044922732652
- 35 USC 102 Novelty (BERT): 0.5926160156335598
- Combined Prediction Score: 0.6526356446092947
- Mean Citation Score: 261.93600000000004
- Max Citation Score: 598.6844
- Similarity Product: 403.18072210702894

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test