PATENT CLAIM ANALYSIS

Application Number: 16227810
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["424", "133100"]

Abstract:
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).

Claim (Index 153):
A method for treating cancer in a subject by activating T cells in vivo, comprising administering to the subject\n (i) a first mRNA encoding a human IL-23 polypeptide, wherein the first mRNA comprises an ORF comprising a nucleotide sequence at least 90% identical to the nucleotide sequence as set forth in SEQ ID NO: 141 or comprises the nucleotide sequence as set forth in SEQ ID NO: 141; (ii) a second mRNA encoding a human IL-36gamma polypeptide, wherein the second mRNA comprises an ORF comprising a nucleotide sequence at least 90% identical to the nucleotide sequence as set forth in SEQ ID NO: 143 or comprises the nucleotide sequence as set forth in SEQ ID NO: 143; and (iii) a third mRNA encoding a human OX40L polypeptide, wherein the third mRNA comprises an ORF comprising a nucleotide sequence at least 90% identical to the nucleotide sequence as set forth in SEQ ID NO: 145, or comprises the nucleotide sequence as set forth in SEQ ID NO: 145, thereby activating T cells in vivo to treat cancer in the subject.

Metadata:
- Claim Count in Document: 79.0
- Percentile: 98.0
- Lexical Diversity: 1.73684
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16184282', '16222155', '15995889', '16219418', '15996146']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8588005177957677
- 35 USC 102 Novelty (BERT): 0.64103706823352
- Combined Prediction Score: 0.8370241728395429
- Mean Citation Score: 671.050294
- Max Citation Score: 719.048
- Similarity Product: 557.8670891456604

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test