PATENT CLAIM ANALYSIS

Application Number: 15953108
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "279000"]

Abstract:
The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

Claim (Index 15):
The bifunctional compound according to any of  claims 2 - 7 , wherein the linker comprises a structure selected from: wherein:\n W L1  and W L2  are each independently absent, aryl, heteroaryl, cyclic, heterocyclic, C 1-6  alkyl and optionally one or more C atoms are replaced with O, C 1-6  alkene and optionally one or more C atoms are replaced with O, C 1-6  alkyne and optionally one or more C atoms are replaced with O, bicyclic, biaryl, biheteroaryl, or biheterocyclic, each optionally substituted with R Q , each R Q  is independently a H, halo, OH, CN, CF 3 , hydroxyl, nitro, C\u2261CH, C 2-6  alkenyl, C 2-6  alkynyl, C 1 -C 6  alkyl (linear, branched, optionally substituted), C 1 -C 6  alkoxy (linear, branched, optionally substituted), OC 1-3 alkyl (optionally substituted by 1 or more \u2014F), OH, NH 2 , NR Y1 R Y2 , CN, or 2 R Q  groups taken together with the atom they are attached to, form a 4-8 membered ring system containing 0-4 heteroatoms; \n Y L1  is each independently a bond, NR YL1 , O, S, NR YL2 , CR YL1 R YL2 , C\u2550O, C\u2550S, SO, SO 2 , C 1 -C 6  alkyl (linear, branched, optionally substituted) and optionally one or more C atoms are replaced with O; C 1 -C 6  alkoxy (linear, branched, optionally substituted); \n Q L  is a 3-6 membered alicyclic or aromatic ring with 0-4 heteroatoms, optionally bridged, optionally substituted with 0-6 R Q , each R Q  is independently H, C 1-6  alkyl (linear, branched, optionally substituted by 1 or more halo, C 1-6  alkoxyl), or 2 R Q  groups taken together with the atom they are attached to, form a 3-8 membered ring system containing 0-2 heteroatoms); \n R YL1 , R YL2  are each independently H, OH, C 1-6  alkyl (linear, branched, optionally substituted by 1 or more halo, C 1-6  alkoxyl), or R 1 , R 2  together with the atom they are attached to, form a 3-8 membered ring system containing 0-2 heteroatoms); \n n is 0-10; and \n a dashed line indicates the attachment point to the PTM or CLM moieties.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.675
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15881318', '14822309', '15730728', '16346483', '15148253']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7904036800041541
- 35 USC 102 Novelty (BERT): 0.5781094257899926
- Combined Prediction Score: 0.7691742545827379
- Mean Citation Score: 365.22769200000016
- Max Citation Score: 518.0048
- Similarity Product: 375.6256483752251

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test