PATENT CLAIM ANALYSIS

Application Number: 15761885
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "217010"]

Abstract:
The present invention pertains to the field of chemical medicine, particularly to 4-substituted coumarin derivatives and preparation methods and applications thereof. The invention provides 4-substituted coumarin derivatives with a structural formula as shown in Formula I. The invention also provides preparation methods and applications for the above 4-substituted coumarin derivatives. The compounds provided in the invention have strong anti-tumor activity with IC50 for plural tumor cell lines between 0.01-5 nM, and it also performs better to inhibit microtubule polymerization and has diversified biological activities and low toxicity, providing new options for drug-sensitive and drug-resistant tumor cells.

Claim (Index 25):
The 4-substituted coumarin derivative according to  claim 24 , wherein, R 11  is C1-C10 alkyl, C2-C8 alkenyl, C1-C4 alkyl substituted by halogen, C3-C8 cycloalkyl or z=1-10; R 18  is C1-C4 alkyl or \u2014H.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 90.0
- Lexical Diversity: 1.56061
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12989410', '14625532', '11829531', '15102968', '14342656']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7636992656229787
- 35 USC 102 Novelty (BERT): 0.5518551884556602
- Combined Prediction Score: 0.7425148579062468
- Mean Citation Score: 385.338274
- Max Citation Score: 398.68192
- Similarity Product: 316.17139002212525

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test