PATENT CLAIM ANALYSIS

Application Number: 15755893
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "418000"]

Abstract:
The invention relates to antibacterial compounds of formula I wherein X represents sulphur or CH═CH; R 1  represents H, PO 3 H 2 , SO 3 H, phosphonooxymethyl or the group —CO—R 2  wherein R 2  is as defined in the claims M is one of the groups M A  and M B  represented below   wherein A represents a bond or C≡C and R 1A , R 2A , R 3A  and R 1B  are as defined in the claims; and to salts thereof.

Claim (Index 1):
A compound of formula I wherein\n X represents sulphur or CH\u2550CH; \n R 1  represents H, PO 3 H 2 , SO 3 H, phosphonooxymethyl or the group L represented below \n wherein\n R 2  represents (C 1 -C 4 )alkylamino(C 1 -C 4 )alkyl, di(C 1 -C 4 )alkylamino(C 1 -C 4 )alkyl, phosphonooxy(C 1 -C 4 )alkyl, phosphonooxymethoxy, 2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl, [2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl]-(C 1 -C 4 )alkyl, or (2-(phosphonooxy)-phenyl)-(C 1 -C 4 )alkyl; \n M is one of the groups M A  and M B  represented below \n wherein A represents a bond or C\u2261C; R 1A  represents H or halogen; R 2A  represents H or halogen; R 3A  represents H, (C 1 -C 3 )alkoxy, hydroxy(C 2 -C 4 )alkoxy, hydroxy(C 1 -C 4 )alkyl, 1,2-dihydroxyethyl, (3-fluoroazetidin-1-yl)methyl, 3-fluoro-1-(oxetan-3-yl)azetidin-3-yl, 3-fluoro-1-methyl-azetidin-3-yl, (4-hydroxy-3-fluoropiperidin-1-yl)methyl, (4-hydroxy-3,3-difluoropiperidin-1-yl)methyl, (3-hydroxyazetidin-1-yl)methyl, 3-(\u03c9-hydroxy(C 2 -C 4 )alkyl)-azetidin-1-yl, 1-(oxetan-3-yl)azetidin-3-yl, 1-(oxetan-3-ylmethyl)azetidin-3-yl or (4-hydroxypiperidin-1-yl)methyl; and R 1B  represents amino(C 1 -C 3 )alkyl, 1-amino-cycloprop-1-yl, trans-2-(2-dimethylaminoacetoxymethyl)-cycloprop-1-yl, 1-(2-dimethylaminoacetoxymethyl)-cycloprop-1-yl, 1-(3-hydroxyazetidine)-1-carbonyloxymethyl, 1-hydroxymethyl-cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, 1-fluoro-2-hydroxymethyl-cycloprop-1-yl, 2-fluoro-2-hydroxymethyl-cycloprop-1-yl, 1-{[(2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl)-(C 1 -C 4 )alkyl]carbonyloxymethyl}cycloprop-1-yl, 1-{[2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl]carbonyloxymethyl}cycloprop-1-yl, 1-{[(2-phosphonooxy-phenyl)-(C 1 -C 4 )alkyl]carbonyloxymethyl}cycloprop-1-yl, trans-2-{[(2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl)-(C 1 -C 4 )alkyl]carbonyloxymethyl}cycloprop-1-yl, trans-2-{[2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl]carbonyloxymethyl}cycloprop-1-yl, trans-2-{[(2-phosphonooxy-phenyl)-(C 1 -C 4 )alkyl]carbonyloxymethyl}cycloprop-1-yl, 2-fluoro-2-{[(2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl)-(C 1 -C 4 )alkyl]carbonyloxymethyl}cycloprop-1-yl, 2-fluoro-2-{[2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl]carbonyloxymethyl}cycloprop-1-yl, 2-fluoro-2-{[(2-phosphonooxy-phenyl)-(C 1 -C 4 )alkyl]carbonyloxymethyl}cycloprop-1-yl, 2-fluoro-2-(phosphonooxymethyl)-cycloprop-1-yl, 1-methyl-2-hydroxymethyl-cycloprop-1-yl, 2-hydroxymethyl-2-methylcycloprop-1-yl, 1-(2-hydroxyacetyl)-azetidin-3-yl, trans-(cis-3,4-dihydroxy)-cyclopent-1-yl, 2-(1,2-dihydroxyethyl)cycloprop-1-yl, 1-(dimethylamino)cycloprop-1-yl, 2-(morpholinomethyl)cycloprop-1-yl, 2-((3-fluoroazetidin-1-yl)methyl)cyclopropyl, N\u2014(C 1 -C 4 )alkyl-azetidin-3-yl, N\u2014(C 3 -C 6 )cycloalkyl-azetidin-3-yl, 3-fluoro-1-methyl-azetidin-3-yl, 1-(methylamino)cycloprop-1-yl, N-(\u03c9-hydroxy(C 2 -C 4 )alkyl)-azetidin-3-yl, 2-(hydroxymethyl)-1-methylazetidin-3-yl, N-(2-hydroxy-2-methylpropyl)azetidin-3-yl, N-(\u03c9-halo(C 2 -C 4 )alkyl)-azetidin-3-yl, 1-(3-hydroxypropyloxycarbonyl)-azetidin-3-yl, 2-(fluoromethyl)-1-methylazetidin-3-yl, N-(3-hydroxycyclobutyl)azetidin-3-yl, N-(oxetan-3-ylmethyl)azetidin-3-yl, N-(3-hydroxyoxetan-3-ylmethyl)azetidin-3-yl, N-(tetrahydrofuran-3-yl)azetidin-3-yl, N-(tetrahydro-2H-pyran-4-yl)azetidin-3-yl, trans-2-hydroxymethyl-1-methylazetidin-4-yl, (5-hydroxymethyl)-1-methylpyrrolidin-3-yl, 4-fluoro-1-methylpiperidin-4-yl, or 1-(oxetan-3-yl)-azetidin-3-yl; or a salt thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.71154
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15756366', '15123184', '15021649', '15311758', '15106790']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8250066284268358
- 35 USC 102 Novelty (BERT): 0.6029490285907079
- Combined Prediction Score: 0.8028008684432231
- Mean Citation Score: 514.21681
- Max Citation Score: 555.8367
- Similarity Product: 443.95451092679497

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test