PATENT CLAIM ANALYSIS

Application Number: 15757435
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-01
Patent Classification: ["514", "291000"]

Abstract:
It is an object of the present invention to provide a pharmaceutical composition, which can suppress a reduction in the content of an active ingredient caused by oxidation or decomposition of rapamycin or a derivative thereof, can ensure long-term stability, and has high safety. In the present invention, the inventors have found that (B) a salt of an ascorbic acid or a derivative thereof and/or a salt of chelating agent is used in a pharmaceutical formulation comprising rapamycin or a derivative thereof, so that oxidation or decomposition of the rapamycin or a derivative thereof can be suppressed, thereby completing the present invention. The rapamycin or a derivative thereof, and (B) the salt of an ascorbic acid or a derivative thereof and/or the salt of chelating agent are preferably in the form of a solid mixture produced by preparing a solution containing these components and then removing the solvent from the solution.

Claim (Index 8):
A method for producing a pharmaceutical formulation comprising rapamycin or a derivative thereof, which comprises preparing a solution containing (A) rapamycin or a derivative thereof, and (B) a salt of an ascorbic acid or a derivative thereof and/or a salt of chelating agent, then mixing the solution with a cellulose derivative and/or sugars, and then removing the solvent from the mixture.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 2.17105
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15747604', '15606594', '10510756', '14335080', '15569682']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.717611148950097
- 35 USC 102 Novelty (BERT): 0.518032813867739
- Combined Prediction Score: 0.6976533154418613
- Mean Citation Score: 209.161886
- Max Citation Score: 329.44733
- Similarity Product: 295.9950225392092

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test