PATENT CLAIM ANALYSIS

Application Number: 15750683
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "182000"]

Abstract:
The present application relates to a method of preparing compounds of Formula (A) or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof.

Claim (Index 17):
A method of preparing a compound of Formula (A): or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein:\n R 1  is \u03b1-OH or an oxo group; \n R 2  is H, F, \u03b1-C 1 -C 3  alkyl optionally substituted with F or OH, \u03b1-C 1 -C 3  alkoxy, \u03b1-C 2 -C 3  alkenyl or alkynyl, or cycloalkyl; \n R 3  or R 7  are independently H, F, or C 1 -C 4  alkyl optionally substituted with F or OH, or R 3  or R 7  taken together with another R 3  or R 7  on an adjacent carbon atom forms a substituted or unsubstituted C 1 -C 6  carbocyclic or heterocyclic ring; \n R 4 , R 5  and R 8  are each independently H, \u03b1-OH, or \u03b2-OH; \n R 6  is CO 2 H, OSO 3 H, NH 2 , NHCO 2 (CH 2 CHCH)phenyl, NHCO 2 CH 2 CH 3 , C(O)NHOH, C(O)NH(CH 2 ) 2 OH, CONH(CH 2 ) 2 OSO 3 H, or an optionally substituted 5-member heterocycle comprising 1-4 heteroatoms selected from N, S and O; and \n n is 0, 1, 2 or 3; \n comprising the steps of:\n (1) converting Compound 1 to Compound 2 \n wherein \u201c \u201d indicates that the OH at the C3-position or C7-position is in an \u03b1- or \u03b2-stereochemistry; (2) converting Compound 2 to Compound 5 wherein:\n X is a leaving group; and \n P 1  and P 2  are each independently a protecting group; \n (3) converting Compound 5 to Compound 7 and\n (4) converting Compound 7 to a compound of Formula (A)

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 1.16
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15748716', '13129947', '12523670', '13838868', '13056797']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7835214666344255
- 35 USC 102 Novelty (BERT): 0.5140571207413605
- Combined Prediction Score: 0.756575032045119
- Mean Citation Score: 285.15945
- Max Citation Score: 303.5368
- Similarity Product: 220.94227422409057

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test