PATENT CLAIM ANALYSIS

Application Number: 15775647
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "171000"]

Abstract:
Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.

Claim (Index 17):
A compound of formula (XII): or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein: n is an integer from 3 to 500; m is an integer from 1 to 5; w is an integer from 1 to 5; GC is a moiety of a glucocorticoid drug molecule; A is absent, C 1 -C 6  alkylene, or C 6 -C 10  arylene; B is absent, NR 4 , O, or C(O); D is absent, NR 4 , O, C(O), or CR 5 R 5 ; E is absent, C 1 -C 6  alkylene, or a linker comprising a branched structure capable of connecting to two or more R 2  groups, said linker optionally comprising one, two, or more heteroatoms independently selected from the group consisting of O, S, and N; G is absent, NR 4 , or O; P is absent or C(O); Q is absent, C 6 -C 10  arylene, or C 1 -C 6  alkylene; T is absent, C 1 -C 6  alkylene, C 6 -C 10  arylene, or C(O); X is absent, O, S, or NR 4 ; Y is absent, C(O), C 6 -C 10  arylene, or C 1 -C 6  alkylene; Z is absent, NR 4 , O, C 1 -C 6  alkylene, or a linker comprising a branched structure capable of connecting to one or more dexamethasone moieties, said linker optionally comprising one or more heteroatoms independently selected from the group consisting of O, S, and N; R 1  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 6 -C 10  aryl, 5-10 membered heteroaryl, or 5-10 membered heterocyclyl, each group except H optionally substituted by one to five substituents independently selected from the group consisting of C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, halogen, oxo (\u2550O), \u2014NR a R b , \u2014NO 2 , \u2014CN, \u2014OR 3 , and \u2014SR 3 ; or alternatively, R 1  is \u2014CH 2 -A-B-D-E-(R 2 ) m ; R 3  at each occurrence is independently H, C 1 -C 4  alkyl, or C 1 -C 4  haloalkyl; R 4  at each occurrence is independently H or C 1 -C 4  alkyl; R 5  at each occurrence is independently H, C 1 -C 4  alkyl, or C 1 -C 4  haloalkyl; R a  and R b  are each independently H or C 1 -C 4  alkyl; and wherein when any of groups A, B, D, E, G, P, Q, T, X, Y, and Z is absent, its two available adjacent groups are single-bonded to each other directly.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 93.0
- Lexical Diversity: 1.39474
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13837195', '11996009', '14448998', '14670425', '14670422']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7257264314079139
- 35 USC 102 Novelty (BERT): 0.5047252922425495
- Combined Prediction Score: 0.7036263174913775
- Mean Citation Score: 234.029932
- Max Citation Score: 241.24754
- Similarity Product: 155.16043361061452

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test