PATENT CLAIM ANALYSIS

Application Number: 15902883
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "210180"]

Abstract:
The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Claim (Index 50):
A method for treating an HIV infection in a human, comprising administering a compound of formula I: or a pharmaceutically acceptable salt thereof, to the human, wherein:\n A is pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, wherein any pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl of A is substituted with one Z 1  group and optionally substituted with 1, 2, or 3 Z 2  groups; \n B is absent; or B is \u2014O \u2212  and the nitrogen to which the \u2014O \u2212  group is attached is N + ; \n W is \u2014CR 3a R 3b \u2014; \n R 1  is a bicyclic-heteroaryl, tricyclic-heteroaryl, bicyclic-heterocycle or tricyclic-heterocycle, wherein any bicyclic-heteroaryl, tricyclic-heteroaryl, bicyclic-heterocycle or tricyclic-heterocycle of R 1  is optionally substituted with 1, 2, 3, 4, or 5 Z 3  groups; \n R 2  is a 6-membered aryl, 5-membered heteroaryl or 6-membered heteroaryl, wherein any 6-membered aryl, 5-membered heteroaryl or 6-membered heteroaryl of R 2  is optionally substituted with 1, 2, or 3 Z 4  groups; \n each R 3a  and R 3b  is independently selected from H, (C 1 -C 6 )alkyl, (C 1 -C 3 )haloalkyl, (C 1 -C 6 )heteroalkyl, heterocyclyl(C 1 -C 6 )alkyl-; \n each Z 1  is independently selected from (C 2 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle and \u2014OR n1 , wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of Z 1  is optionally substituted with 1, 2, 3, 4, or 5 Z 1a  or Z 1b  groups and wherein any (C 2 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of Z 1  is optionally substituted with 1, 2, 3, 4, or 5 Z 1a  groups; \n each Z 1a  is independently selected from (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle, halogen, \u2014CN, \u2014OR n2 , \u2014OC(O)R p2 , \u2014OC(O)NR q2 R r2 , \u2014SR n2 , \u2014S(O)R p2 , \u2014S(O) 2 OH, \u2014S(O) 2 R p2 , \u2014S(O) 2 NR q2 R r2 , \u2014NR q2 R r2 , \u2014NR n2 COR p2 , \u2014NR n2 CO 2 R p2 , \u2014NR n2 CONR q2 R r2 , \u2014NR n2 S(O) 2 R p2 , \u2014NR n2 S(O) 2 OR p2 , \u2014NR n2 S(O) 2 NR q2 R r2 , NO 2 , \u2014C(O)R n2 , \u2014C(O)OR n2 , \u2014C(O)NR q2 R r2  and \u2014S(O) 2 NR n2 COR p2 , wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of Z 1a  is optionally substituted with 1, 2, 3, 4, or 5 Z 1c  or Z 1d  groups; \n each Z 1b  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl, wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of Z 1b  is optionally substituted with 1, 2, 3, 4, or 5 Z 1c  groups; \n each Z 1c  is independently selected from (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle, halogen, \u2014CN, \u2014OR n3 , \u2014OC(O)R p3 , \u2014OC(O)NR q3 R r3 , \u2014SR n3 , \u2014S(O)R p3 , \u2014S(O) 2 OH, \u2014S(O) 2 R p3 , \u2014S(O) 2 NR q3 R r3 , \u2014NR q3 R r3 , \u2014NR n3 COR p3 , \u2014NR n3 CO 2 R p3 , \u2014NR n3 CONR q3 R r3 , \u2014NR n3 S(O) 2 R p3 , \u2014NR n3 S(O) 2 OR p3 , \u2014NR n3 S(O 2 NR q3 R r3 , NO 2 , \u2014C(O)R n3 , \u2014C(O)OR n3 , \u2014C(O)NR q3 R r3 , (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle and (C 1 -C 8 )heteroalkyl; \n each Z 1d  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and (C 1 -C 8 )haloalkyl; \n each R n1  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R n1  is optionally substituted with 1, 2, 3, 4, or 5 Z 1a  or Z 1b  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R n1  is optionally substituted with 1, 2, 3, 4, or 5 Z 1a  groups; \n each R n2  is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R n2  is optionally substituted with 1, 2, 3, 4, or 5 Z 1c  or Z 1d  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R n2  is optionally substituted with 1, 2, 3, 4, or 5 Z 1c  groups; \n each R p2  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R p2  is optionally substituted with 1, 2, 3, 4, or 5 Z 1c  or Z 1d  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R p2  is optionally substituted with 1, 2, 3, 4, or 5 Z 1c  groups; \n R q2  and R r2  are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R q2  or R r2  is optionally substituted with 1, 2, 3, 4, or 5 Z 1c  or Z 1d  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R q2  or R r2  is optionally substituted with 1, 2, 3, 4, or 5 Z 1c  groups, or R q2  and R r2  together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4 or 5 Z 1c  or Z 1d  groups; \n each R n3  is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl; \n each R p3  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl; \n R q3  and R r3  are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl, or R q3  and R r3  together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle; \n each Z 2  is independently selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 3 -C 7 )carbocycle, halogen, CN, OH and \u2014O(C 1 -C 6 )alkyl; \n each Z 3  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, halogen, \u2014CN, \u2014OR n4 , \u2014S(O)R p4 , \u2014NR n4 CO 2 R p4 , \u2014NR n4 S(O) 2 R p4 , \u2014C(O)R n4 , \u2014C(O)OR n4 , \u2014C(O)NR q4 R r4  and \u2014B(OR q4 )(OR r4 ) wherein any (C 3 -C 7 )carbocycle and (C 6 -C 20 )aryl of Z 3  is optionally substituted with 1, 2, 3, 4, or 5 Z 3a  or Z 3b  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of Z 3  is optionally substituted with 1, 2, 3, 4, or 5 Z 3a  groups; \n each Z 3a  is independently selected from (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle, halogen, \u2014CN, \u2014OR n5 , \u2014OC(O)R p5 , \u2014OC(O)NR q5 R r5 , \u2014SR n5 , \u2014S(O)R p5 , \u2014S(O) 20 H, \u2014S(O) 2 R p5 , \u2014S(O) 2 NR q5 R r5 , \u2014NR q5 R r5 , \u2014NR n5 COR p5 , \u2014NR n5 CO 2 R p5 , \u2014NR n5 CONR q5 R r5 , \u2014NR n5 S(O) 2 R p5 , \u2014NR n5 S(O) 2 OR p5 , \u2014NR n5 S(O) 2 NR q5 R r5 , NO 2 , \u2014C(O)R n5 , \u2014C(O)OR n5 , and \u2014C(O)NR q5 R r5 , wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of Z 3a  is optionally substituted with 1, 2, 3, 4, or 5 Z 3c  or Z 3d  groups; \n each Z 3b  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl, wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of Z 3b  is optionally substituted with 1, 2, 3, 4, or 5 Z 3c  groups; \n each Z 3c  is independently selected from (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle, halogen, \u2014CN, \u2014OR n6 , \u2014OC(O)R p6 , \u2014OC(O)NR q6 R r6 , \u2014SR n6 , \u2014S(O)R p6 , \u2014S(O) 20 H, \u2014S(O) 2 R p6 , \u2014S(O) 2 NR q6 R r6 , \u2014NR q6 R r6 , \u2014NR n6 COR p6 , \u2014NR n6 CO 2 R p6 , \u2014NR n6 CONR q6 R r6 , \u2014NR n6 S(O) 2 R p6 , \u2014NR n6 S(O) 2 OR p6 , \u2014NR n6 S(O) 2  NR q6 R r6 , NO 2 , \u2014C(O)R n6 , \u2014C(O)OR n6 , \u2014C(O)NR q6 R r6 , (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle and (C 1 -C 8 )heteroalkyl; \n each Z 3d  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, and (C 1 -C 8 )haloalkyl; \n each R n4  is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R n4  is optionally substituted with 1, 2, 3, 4, or 5 Z 3a  or Z 3b  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R n4  is optionally substituted with 1, 2, 3, 4, or 5 Z 3a  groups; \n each R p4  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, or heterocycle of R p4  is optionally substituted with 1, 2, 3, 4, or 5 Z 3a  or Z 3b groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl or (C 2 -C 8 )alkynyl of R p4  is optionally substituted with 1, 2, 3, 4, or 5 Z 3a  groups; \n R q4  and R r4  are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R q4  or R r4  is optionally substituted with one or more Z 3a  or Z 3b  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R q4  or R r4  is optionally substituted with 1, 2, 3, 4, or 5 Z 3a  groups, or R q4  and R r4  together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4, or 5 Z 3a  or Z 3b  groups; \n each R n5  is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R n5  is optionally substituted with 1, 2, 3, 4, or 5 Z 3c  or Z 3d  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R n5  is optionally substituted with 1, 2, 3, 4, or 5 Z 3c  groups; \n each R p5  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R p5  is optionally substituted with 1, 2, 3, 4, or 5 Z 3c  or Z 3d  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R p5  is optionally substituted with 1, 2, 3, 4, or 5 Z 3c  groups; \n R q5  and R r5  are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl and (C 6 -C 20 )aryl, wherein any (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl and heterocycle of R q5  or R r5  is optionally substituted with 1, 2, 3, 4, or 5 Z 3c  or Z 3d  groups, and wherein any (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl and (C 2 -C 8 )alkynyl of R q5  or R r5  is optionally substituted with 1, 2, 3, 4, or 5 Z 3c  groups, or R q5  and R r5  together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4, or 5 Z 3c  or Z 3d  groups; \n each R n6  is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl; \n each R p6  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl; \n R q6  and R r6  are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl, or R q6  and R r6  together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle; \n each Z 4  is independently selected from (C 3 -C 7 )carbocycle, halogen, methyl and \u2014CN; \n each Z 4  is independently selected from of (C 3 -C 7 )carbocycle, (C 6 -C 20 )aryl, heteroaryl, heterocycle, halogen, \u2014CN, \u2014OR n9 , \u2014OC(O)R p9 , \u2014OC(O)NR q9 R r9 , \u2014SR n9 , \u2014S(O)R p9 , \u2014S(O) 2 OH, \u2014S(O) 2 R p9 , \u2014S(O) 2 NR q9 R r9 , \u2014NR q9 R r9 , \u2014NR n9 COR p9 , \u2014NR n9 CO 2 R p9 , \u2014NR n9 CONR q9 R r9 , \u2014NR n9 S(O) 2 R p9 , \u2014NR n9 S(O) 2 OR p9 , \u2014NR n9 S(O) 2  NR q9 R r9 , NO 2 , \u2014C(O)R n9 , \u2014C(O)OR n9 , \u2014C(O)NR q9 R r9 , (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle and (C 1 -C 8 )heteroalkyl; \n each Z 4d  is independently selected from of (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and (C 1 -C 8 )haloalkyl; \n each R r9  is independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl; \n each R p9  is independently selected from (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl; and \n R q9  and R r9  are each independently selected from H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 7 )carbocycle, heterocycle, heteroaryl, (C 6 -C 20 )aryl, (C 6 -C 20 )haloaryl, haloheteroaryl, haloheterocycle, (C 1 -C 8 )haloalkyl and (C 1 -C 8 )heteroalkyl; or R q9  and R r9  together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 1.60465
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14130882', '14151758', '14151762', '14771779', '14151746']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7891083808092109
- 35 USC 102 Novelty (BERT): 0.6000519236711048
- Combined Prediction Score: 0.7702027350954003
- Mean Citation Score: 484.522874
- Max Citation Score: 586.5975
- Similarity Product: 425.372359521389

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test