PATENT CLAIM ANALYSIS

Application Number: 15779353
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["514", "210180"]

Abstract:
The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.

Claim (Index 3):
A compound of Formula I, including pharmaceutically acceptable salts, polymorphs, and isomers thereof: wherein:\n X is CH or N; \n Z is CH or N; with the proviso that when X is CH, Z is not also CH; \n Y is selected from the group consisting of hydrogen (H), Cl, alkyl, cycloalkyl, heterocycloalkyl, OR 5 , NR 6 R 7 , aryl and heteroaryl, wherein said heterocycloalkyl and heteroaryl include one or more nitrogen (N), oxygen (O) or sulfur (S) atoms; wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl may each optionally be substituted by one or more R 8 ; \n L 1  is \u2014(CR 9 R 10 ) n \u2014, C(O) or S(O) 2 ; \n n is 0, 1, 2, or 3; \n R 1  is selected from the group consisting of aryl and heteroaryl, wherein said heteroaryl includes one or more N, O or S atoms; wherein each of said aryl and heteroaryl may optionally be substituted with one or more R 8 ; \n R 2  is H, alkyl, \u2014C(O)R 11 , \u2014CH 2 C(O)OR 11 , \u2014C(O)NR 11 R 12 , S(O) 2 NR 11 R 12  or \u2014C(O)OR 11 , wherein said alkyl is optionally substituted with one or more R 8 ; \n optionally, R 1  and R 2 , together with the included nitrogen atom and L 1 , may form a 4-, 5-, 6- or 7-membered heterocyclic ring system, wherein said heterocyclic ring system may include one or more additional N, O or S atoms; and wherein said heterocyclic ring system may optionally be substituted with one or more R 8 ; \n R 3  and R 4  are independently selected for each occurrence from the group consisting of H, alkyl, \u2014OR 11 , halogen, \u2014CN, \u2014CF 3 , \u2014NO 2 , \u2014C(O)OR 11 , \u2014OC(O)NR 11 R 12 , \u2014C(O)NR 11 R 12 , \u2014NR 11 R 12 , \u2014NR 11 C(O)R 12 , \u2014NR 11 C(O)OR 12 , \u2014NR 11 S(O) 2 R 12 , \u2014NR 11 C(O)NR 12 R 13 , S(O) 2 NR 11 R 12 , aryl, heteroaryl, cycloalkyl and heterocycloalkyl, wherein each of said heterocycloalkyl and heteroaryl include one or more N, O or S atoms; wherein said alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl are each optionally substituted with one or more R 8 ; \n R 5  is alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, wherein each of said alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more R 8 ; \n R 6  and R 7  are independently selected for each occurrence from the group consisting of H, alkyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl, wherein said heterocycloalkyl or heteroaryl include one or more N, O or S atoms; wherein each of said alkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl may optionally be substituted with one or more R 8 ; \n optionally, R 6  and R 7 , together with the included nitrogen, may form a 4-, 5-, 6- or 7-membered heterocyclic ring system, wherein said heterocyclic ring system is a mono- or bicyclic ring optionally having an additional from one to four heteroatoms selected from N, O and S; wherein said cyclic ring system may optionally be substituted with one or more R 8 ; \n R 8  is selected independently for each occurrence from the group consisting of H, OH, SH, halogen, \u2014CN, \u2014CF 3 , \u2014NO 2 , \u2014OR 11 , \u2014SR 11 , \u2014C(O)OR 11 , \u2014OC(O)NR 11 R 12 , \u2014C(O)NR 11 R 12 , \u2014NR 11 R 12 , \u2014NR 11 C(O)R 12 , \u2014NR 11 C(O)OR 12 , \u2014NR 11 S(O) 2 R 12 , \u2014NR 11 C(O)NR 12 R 13 , \u2014(CH 2 ) m \u2014R 16 , \u2014(CH 2 ) q \u2014R 17 , alkyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl, wherein said alkyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl are each optionally substituted with one or more R 14 ; \n m is 1, 2, 3 or 4; \n q is 2, 3 or 4; \n R 9  and R 10  are independently chosen for each occurrence from H or alkyl, wherein said alkyl may optionally be substituted with one or more R 8 ; \n optionally, R 9  and R 10 , together with the included carbon, may form a 3-, 4-, 5-, or 6-membered carbocyclic ring system; \n R 11 , R 12 , and R 13  are independently chosen for each occurrence from the group consisting of H, alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, wherein each of said alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl may optionally be substituted with one or more R 14 ; \n optionally, R 11  and R 12 , or R 12  and R 13 , together with the included nitrogen, may form a 4-, 5-, 6- or 7-membered heterocyclic ring system, wherein said heterocyclic ring system is a mono- or bicyclic ring optionally having an additional from one to four heteroatoms selected from N, O and S; wherein said cyclic ring system may optionally be substituted with one or more R 14 ; \n R 14  is selected independently for each occurrence from the group consisting of H, OH, OR 18 , SH, SR 18 , halogen, CN, CF 3 , NO 2 , C(O)R 18 , C(O)OR 18 , OC(O)NR 18 R 19 , C(O)NR 18 R 19 , NR 18 R 19 , NR 18 C(O)R 19 , NR 18 C(O)OR 19 , NR 18 S(O) 2 R 19 , NR 18 C(O)NR 19 R 20 , S(O)R 18 , S(O) 2 R 18 , alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl groups may optionally be further substituted with one or more of R 15 ; \n R 15  is selected independently for each occurrence from the group consisting of H, \u2014CH 3 , \u2014CH 2 CH 3 , n-propyl, isopropyl, \u2014OCH 3 , halogen, \u2014CN, \u2014CF 3 , \u2014NH 2 , \u2014N(CH 3 ) 2 , \u2014CO 2 H, \u2014C(O)NH 2 , \u2014C(O)NH(CH 3 ), and \u2014C(O)N(CH 3 ) 2 ; \n each R 16  is independently \u2014CO 2 H or \u2014C(O)NR 6 R 7 ; \n each R 17  is independently \u2014OH or \u2014NR 6 R 7 ; and \n each R 18 , R 19 , and R 20  are independently selected for each occurrence from the group consisting of H, alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 93.0
- Lexical Diversity: 1.48485
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15398907', '15906163', '14977508', '15110361', '15424616']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8113982169330244
- 35 USC 102 Novelty (BERT): 0.5363516784037758
- Combined Prediction Score: 0.7838935630800995
- Mean Citation Score: 352.129134
- Max Citation Score: 384.88992
- Similarity Product: 253.2033313629913

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test