PATENT CLAIM ANALYSIS

Application Number: 16190669
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-08
Patent Classification: ["424", "649000"]

Abstract:
The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.

Claim (Index 2):
The process of  claim 1 , further comprising reacting the compound of formula IV with a compound of formula IX, wherein R 2  is heterocycle or substituted heterocycle, aryl or substituted aryl; and R 3  is hydrogen, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, heterocycle or substituted heterocycle, aryl or substituted aryl; to provide a compound of formula I or a pharmaceutically-acceptable salt thereof, wherein: R 1  is hydrogen, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, aryl or substituted aryl, OR a , SR a , S(\u2550O) 2 R e , S(\u2550O) 2 OR e , C(\u2550O)OR d , C(\u2550O)R a , or C(\u2550O)NR b R c ; R 2  is heterocycle or substituted heterocycle, aryl or substituted aryl; R 3  is hydrogen, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, heterocycle or substituted heterocycle, aryl or substituted aryl; R 4 , R 7 , and R 8  are each independently hydrogen, halogen, cyano, nitro, CF 3 , OCF 3 , alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, aryl or substituted aryl, OR a , SR a , S(\u2550O)R e , S(\u2550O) 2 R e , P(\u2550O) 2 R e , S(\u2550O) 2 OR e , P(\u2550O) 2 OR e , NR b R c , NR b S(\u2550O) 2 R e , NR b P(\u2550O) 2 R e , S(\u2550O) 2 NR b R c , P(\u2550O) 2 NR b R c , C(\u2550O)OR e , C(\u2550O)R a , C(\u2550O)NR b R c , OC(\u2550O)R a , OC(\u2550O)NR b R c , NR b C(\u2550O)OR e , NR d C(\u2550O)NR b R c , NR d S(\u2550O) 2 NR b R c , NR d P(\u2550O) 2 NR b R c , NR b C(\u2550O)R a , or NR b P(\u2550O) 2 R e ; R 5  is alkyl or substituted alkyl, heterocycle or substituted heterocycle, aryl or substituted aryl; R 6  is hydrogen, halogen, cyano, nitro, CF 3 , OCF 3 , alkyl or substituted alkyl, heterocycle or substituted heterocycle, aryl or substituted aryl, or OR a ; R a  is hydrogen, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, or aryl or substituted aryl; R b , R c  and R d  are independently hydrogen, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, heterocycle or substituted heterocycle, or aryl or substituted aryl, or said R b  and R c  together with the N to which they are bonded optionally form a heterocycle or substituted heterocycle; and R e  is alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocycle or substituted heterocycle, or aryl or substituted aryl.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 98.0
- Lexical Diversity: 1.59524
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14445783', '14208170', '14499299', '11168682', '11396888']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7854840181867406
- 35 USC 102 Novelty (BERT): 0.5794996835496871
- Combined Prediction Score: 0.7648855847230353
- Mean Citation Score: 433.34546
- Max Citation Score: 490.76813
- Similarity Product: 432.029115846287

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test