PATENT CLAIM ANALYSIS

Application Number: 15919534
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["548", "418000"]

Abstract:
Hydrazone compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.

Claim (Index 4):
A method of treating a cannabinoid receptor-mediated disease or disorder comprising administering to a subject in need thereof a therapeutically effective amount of a hydrazone compound or a pharmaceutically-acceptable salt thereof, the cannabinoid receptor-mediated disease or disorder selected from the group consisting of glaucoma, diabetes, melanoma, lymphoma, glioma, inflammation, cardiovascular disease, liver fibrosis, osteoporosis, acne, psoriasis, allergic contact dermatitis, pruritis, anxiety, demyelination, spasticity and tremor, Tourette's, Parkinson's disease, multiple sclerosis, stroke, intraocular pressure, diarrhea and nausea, the hydrazone compound comprising a compound of structural Formula II: or a salt or prodrug thereof; wherein: X is selected from the group consisting of C\u2550O, C\u2550S, or SO 2 ; R 1  is selected from the group consisting of alkyl containing from 6 to 12 carbon atoms, a polyether, a substituted benzyl and a radical defined by the following structure: where n is an integer ranging from 1 to 4; but if R 2  is an alkoxy at position 6, then R 1  can also be selected from the group consisting of alkyl containing from 1 to 12 carbon atoms; R 2  and R \u2032 2  vary independently and are selected from the group consisting of hydrogen, aryl, alkyl, cycloalkyl, aralkyl, alkenyl, alkynyl, halogen, an alkoxyl or a hydroxyl; R 3  is selected from the group consisting of NR 15 R 16 , aryl, a heteroaryl, alkenyl, an alkynyl, an alkoxyl, a cycloalkyl containing from 5 to 10 carbon atoms and containing eventually \u2014CO\u2014, \u2014O\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014CHOH\u2014 or \u2014NR 12 \u2014 or one of the radicals defined by the following structure: wherein R 4  and R 5  taken together form a group consisting of a radical cycloalkyl containing from 3 to 10 carbon atoms that are eventually interrupted with one or more hetero atoms or by \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014CHOH\u2014 or \u2014NR 14 \u2014; R 6  is selected from the group consisting of alkyl containing from 1 to 3 carbon atoms; R 7  is selected from the group consisting of alkyl containing from 1 to 3 carbon atoms; R 6  and R 7  taken together can form a cycloalkyl containing from 3 to 10 carbon atoms and eventually interrupted with one or more hetero atoms or by \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014CHOH\u2014 or \u2014NR 13 \u2014; R 8  is selected from the group consisting of hydrogen and alkyl from 1 to 3 carbon atoms; R 9  and R 10  vary independently and are selected from the group consisting of methyl or a hydrogen; R 11  is selected from the group consisting of aryl, heteroaryl, or alkyl containing from 1 to 6 carbon atoms, but if R 2  is alkoxyl, R 11  is heterocycloalkyl; R 12  is selected from the group consisting of hydrogen or alkyl containing from 1 to 3 carbon atoms; R 13  is selected from the group consisting of hydrogen or alkyl containing from 1 to 3 carbon atoms; R 14  represents an alkyl containing from 1 to 3 carbon atoms; and R 15  and R 16  vary independently and are selected from the group consisting of an alkyl containing 1 to 6 carbon atoms or taken together might form a group consisting of a radical cycloalkyl containing from 3 to 10 carbon atoms that are eventually interrupted with one or more hetero atoms or by \u2014CO\u2014, \u2014SO\u2014, \u2014SO2-, \u2014CHOH\u2014 or \u2014NR 14 \u2014.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.38462
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13647134', '14796580', '12668867', '12816657', '14611499']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7781668260196618
- 35 USC 102 Novelty (BERT): 0.5932999035471561
- Combined Prediction Score: 0.7596801337724113
- Mean Citation Score: 403.573736
- Max Citation Score: 495.32452
- Similarity Product: 492.4333287800408

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test