PATENT CLAIM ANALYSIS

Application Number: 15747571
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting a xanthine dehydrogenase (XDH) gene, and methods of using such double stranded RNAi agents to inhibit expression of an XDH gene and methods of treating subjects having an XDH-associated disease.

Claim (Index 11):
The dsRNA agent of any one of  claims 6 - 10 , wherein the modified nucleotides are independently selected from the group consisting of a deoxy-nucleotide, a 3\u2032-terminal deoxy-thymine (dT) nucleotide, a 2\u2032-O-methyl modified nucleotide, a 2\u2032-fluoro modified nucleotide, a 2\u2032-deoxy-modified nucleotide, a locked nucleotide, an unlocked nucleotide, a conformationally restricted nucleotide, a constrained ethyl nucleotide, an abasic nucleotide, a 2\u2032-amino-modified nucleotide, a 2\u2032-O-allyl-modified nucleotide, 2\u2032-C-alkyl-modified nucleotide, 2\u2032-hydroxly-modified nucleotide, a 2\u2032-methoxyethyl modified nucleotide, a 2\u2032-O-alkyl-modified nucleotide, a morpholino nucleotide, a phosphoramidate, a non-natural base comprising nucleotide, a tetrahydropyran modified nucleotide, a 1,5-anhydrohexitol modified nucleotide, a cyclohexenyl modified nucleotide, a nucleotide comprising a phosphorothioate group, a nucleotide comprising a methylphosphonate group, a nucleotide comprising a 5\u2032-phosphate, and a nucleotide comprising a 5\u2032-phosphate mimic.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 86.0
- Lexical Diversity: 1.51515
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14976261', '15670132', '14947025', '15399820', '14650128']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7835161893805852
- 35 USC 102 Novelty (BERT): 0.5520226399000248
- Combined Prediction Score: 0.7603668344325292
- Mean Citation Score: 382.727662
- Max Citation Score: 405.0581
- Similarity Product: 349.0707954777599

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test