PATENT CLAIM ANALYSIS

Application Number: 16114635
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["424", "093210"]

Abstract:
Embodiments of the present invention describe a method of changing the phenotype of monocytes and macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype. The method can comprises providing a composition comprising a recombinant adeno-associated virus (rAAV) vector comprising an exogenous gene encoding ApoA-I Milano or a fragment thereof, and administering the composition to a mammal in need thereof to change the phenotype of monocytes or macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype. By changing the phenotype of monocytes or macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype, atherosclerosis can be treated. The present invention also describes a method of monitoring macrophage phenotypic switching and a method of assessing the efficacy of the treatment of atherosclerosis.

Claim (Index 21):
A method of reducing plaque lipid content or plaque macrophage content in an aortic sinus, an innominate artery, or both, and optionally monitoring the monocyte or macrophage phenotypic switching, in a human subject, comprising:\n providing a composition comprising a recombinant adeno-associated virus 8 (rAAV8) vector comprising an exogenous gene encoding ApoA-I Milano, or fragment thereof; intravenously administering the composition to the human subject in need of changing the phenotype of a monocyte or macrophage from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype to change the phenotype of the monocyte or macrophage from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype, wherein the plaque lipid content or the plaque macrophage content in the aortic sinus, the innominate artery, or both are reduced.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 96.0
- Lexical Diversity: 2.18033
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10599692', '15458560', '14114471', '15036249', '15317673']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6915627720433343
- 35 USC 102 Novelty (BERT): 0.5275965641626753
- Combined Prediction Score: 0.6751661512552685
- Mean Citation Score: 262.89997800000003
- Max Citation Score: 347.70877
- Similarity Product: 251.29358390008989

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test