PATENT CLAIM ANALYSIS

Application Number: 16300301
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-04
Patent Classification: ["544", "363000"]

Abstract:
Disclosed are a crystal form of brexpiprazole and a preparation method therefor. The X-ray powder diffraction pattern, which is detected with Cu—Kα radiation, of the crystal form of brexpiprazole has characteristic peaks at the positions where 2θ is about 9.1±0.2, 15.2±0.2, 15.7±0.2, 17.6±0.2, 18.1±0.2, 24.4±0.2. The crystal form I of brexpiprazole has a high purity, good stability and good reproducibility, and is suitable for industrial production.

Claim (Index 4):
A method for preparing the crystal form I of brexpiprazole having the structure of formula I of  claim 1 , comprising following steps:\n (a) mixing brexpiprazole with a mixed solvent of ethanol and water at room temperature to prepare a suspension; (b) adding acetic acid into the suspension of step (a) and heating to completely dissolved to obtain a clarified solution; and (c) adding the clarified solution of step (b) into a sodium hydroxide solution to pH of 7-14 after cooling, precipitating solids, keeping stirring, filtering and drying to obtain the crystal form I of brexpiprazole.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 98.0
- Lexical Diversity: 1.59184
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16066402', '15294644', '14396224', '16065880', '16065884']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7535706820727192
- 35 USC 102 Novelty (BERT): 0.4895551320834965
- Combined Prediction Score: 0.7271691270737969
- Mean Citation Score: 217.711684
- Max Citation Score: 247.41145
- Similarity Product: 193.71800205734368

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test