PATENT CLAIM ANALYSIS

Application Number: 16053265
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["514", "255000"]

Abstract:
This disclosure relates to pyrazoline dihydroquinolone derivatives, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective NMDA receptor inhibitors and are useful in therapeutic methods related thereto. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a compound of the following formula: or salts, esters, or prodrugs thereof, as provided herein.

Claim (Index 1):
A composition comprising a compound of the following formula: or salts or esters thereof, wherein rings A, B, and C are each individually and independently aryl, cycloalkyl, or heterocyclyl; n, m, and p are each individually and independently 0, 1, 2, 3, or 4; W is at each occurrence CH 2 , CF 2 , CH 2 CH 2 , CH 2 CH 2 CH 2 , CF 2 CH 2 , CH 2 CF 2 , CH, CH\u2550CH, C\u2550O, O, S, or NH; q is 1, 2, or 3; X or Y are each individually and independently O, S, NH, N-alkyl, two hydrogens each singly bonded to the adjacent carbon, or two fluoros each singly bonded to the adjacent carbon; Z is halogen, OH, O-alkyl, O-alkanoyl, NH 2 , N-alkyl, N-alkanoyl, SH, S-alkyl, or S-alkanoyl wherein Z is optionally substituted with one or more the same or different R 10 ; R 1 , R 3 , and R 7  are at each occurrence individually and independently hydrogen, alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, alkanoyl, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, aryl sulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 1 , R 3 , and R 7  are each individually and independently optionally substituted with one or more, the same or different R 10 ; R 10  is alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, alkanoyl, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 7  is optionally substituted with one or more, the same or different, R 11 ; and R 11  is halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methyl sulfinyl, ethyl sulfinyl, mesyl, ethyl sulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl and wherein Formula I is at least in greater than 55%, 65%, 75%, 85%, or 95% enantiomeric excess or diastereomeric excess.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 96.0
- Lexical Diversity: 1.44444
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15558971', '15503875', '15428710', '16046332', '12554134']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7828811937044183
- 35 USC 102 Novelty (BERT): 0.5125276666848144
- Combined Prediction Score: 0.755845841002458
- Mean Citation Score: 289.7414720000001
- Max Citation Score: 300.38727
- Similarity Product: 225.185639694432

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test