PATENT CLAIM ANALYSIS

Application Number: 15867425
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "262100"]

Abstract:
The present invention concerns a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, where R 1 -R 3  and Y are defined in the description, and its use in the treatment of disorders in which pi3 kinase is implicated.

Claim (Index 1):
A method to treat a disorder in which pi3 kinase is implicated, which comprises administering to a subject in need of such treatment a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is C 1 -C 3 -alkyl; \n R 2  is phenyl having the substitution pattern, \n wherein the R 2  phenyl is fused at R 4 -R 5 , R 5 -R 6 , R 6 -R 7  or R 7 -R 8  by a further phenyl, a 5-6 membered heteroaryl group selected from pyrazolyl, imidazoyl, oxazolyl, isoxazolyl, thiazolyl, and isothiazolyl, a C 4 -C 6  carbocyclic group or a 5-6 membered heterocyclyl group, where the fused heteroaryl group is independently optionally substituted by one or more groups selected from List X; List X represents hydroxyl, cyano, nitro, C 1 -C 8 -alkyl, C 1 -C 8 -alkenyl, C 1 -C 8 -alkynyl, C 1 -C 8 -alkoxy, C 1 -C 8 -alkenyloxy, C 1 -C 8 -alkynyloxy, phenyl, a 5-6 membered heteroaryl group, a C 4 -C 6  carbocyclic group or a 5-6 membered heterocyclyl group, \u2014(C 0 -C 4 -alkylene)-O\u2014(C 1 -C 4 -alkylene)-R 9 , (C 0 -C 4 -alkylene)-O\u2014(C 2 -C 4 -alkylene)-R 10 , (C 0 -C 4 -alkylene)-N(R 11 )\u2014(C 1 -C 4 -alkylene)-R 12 , \u2014(C 0 -C 4 -alkylene)-N(R 13 )\u2014(C 2 -C 4 -alkylene)-R 14 , halogen, formyl, C 1 -C 8 -alkylcarbonyl, carboxy, C 1 -C 8 -alkoxycarbonyl, C 1 -C 8 -alkylaminooxycarbonyl, di-C 1 -C 8 -alkylaminooxycarbonyl, amino, C 1 -C 8 -alkylamino, di-C 1 -C 8 -alkylamino, C 1 -C 8 -alkylamidino, \u2014N(H)C(\u2550NH)C 1 -C 8 -alkyl, \u2014N(C 1 -C 8 -alkyl)C(\u2550NH)C 1 -C 8 -alkyl, C 1 -C 8 -alkylaminocarbonyl, di-C 1 -C 8 -alkylaminocarbonyl, aminocarbonylamino, aminocarbonyl(C 1 -C 8 -alkyl)amino, C 1 -C 8 -alkylaminocarbonylamino, di-C 1 -C 8 -alkylaminocarbonylamino, C 1 -C 8 -alkylaminocarbonyl(C 1 -C 8 -alkyl)amino, di-C 1 -C 8 -alkylaminocarbonyl(C 1 -C 8 -alkyl)amino, C 1 -C 8 -alkylcarbonylamino, C 1 -C 8 -alkylcarbonyl(C 1 -C 8 -alkyl)amino, C 1 -C 8 -alkylthiocarbonylamino, C 1 -C 8 -alkylthiocarbonyl(C 1 -C 8 -alkyl)amino, hydroxysulfonyl, C 1 -C 8 -alkylsulfonylamino, C 1 -C 8 -thioalkyl, C 1 -C 8 -alkylsulfinyl, C 1 -C 8 -alkylsulfonyl, aminosulfonyl, C 1 -C 8 -alkylaminosulfonyl or di-C 1 -C 8 -alkylaminosulfonyl, where each of the afore-mentioned hydrocarbon groups may be optionally substituted, where chemically feasible, by one or more halogen, hydroxyl, amino, C 1 -C 4 -alkylamino, di-C 1 -C 4 -alkylamino or C 1 -C 4 -alkoxy groups and where said cyclic groups may be optionally substituted by one or more hydroxyl, cyano, nitro, C 1 -C 8 -alkyl, C 1 -C 8 -alkenyl, C 1 -C 8 -alkynyl, C 1 -C 8 -alkoxy, C 1 -C 8 -alkenyloxy, C 1 -C 8 -alkynyloxy, halogen, C 1 -C 8 -alkylcarbonyl, carboxy, C 1 -C 8 -alkoxycarbonyl, amino, C 1 -C 8 -alkylamino, di-C 1 -C 8 -alkylamino, C 1 -C 8 -alkylaminocarbonyl, di-C 1 -C 8 -alkylaminocarbonyl, C 1 -C 8 -alkylcarbonylamino, C 1 -C 8 -alkylcarbonyl(C 1 -C 8 -alkyl)amino, C 1 -C 8 -alkylsulfonylamino, C 1 -C 8 -thioalkyl, C 1 -C 8 -alkylsulfinyl, C 1 -C 8 -alkylsulfonyl, aminosulfonyl, C 1 -C 8 -alkylaminosulfonyl or di-C 1 -C 8 -alkylaminosulfonyl groups; R 9  and R 12  independently represent hydrogen, C 1 -C 4 -alkenyl, C 1 -C 4 -alkynyl, halogen, cyano, nitro, C 1 -C 8 -alkylcarbonyl, carboxy, C 1 -C 8 -alkoxycarbonyl, C 1 -C 8 -thioalkyl, C 1 -C 8 -alkylsulfinyl, C 1 -C 8 -alkylsulfonyl, aminosulfonyl, C 1 -C 8 -alkylaminosulfonyl, di-C 1 -C 8 -alkylaminosulfonyl, phenyl, a C-linked 5-6 membered heteroaryl group, a C 4 -C 6  carbocyclic group or a C-linked 5-6 membered heterocyclyl group, where said phenyl or cyclic groups may be optionally substituted by one or more hydroxyl, cyano, nitro, C 1 -C 8 -alkyl, C 1 -C 8 -alkenyl, C 1 -C 8 -alkynyl, C 1 -C 8 -alkoxy, C 1 -C 8 -alkenyloxy, C 1 -C 8 -alkynyloxy, halogen, C 1 -C 8 -alkylcarbonyl, carboxy, C 1 -C 8 -alkoxycarbonyl, amino, C 1 -C 8 -alkylamino, di-C 1 -C 8 -alkylamino, C 1 -C 8 -alkylaminocarbonyl, di-C 1 -C 8 -alkylaminocarbonyl, C 1 -C 8 -alkylcarbonylamino, C 1 -C 8 -alkylcarbonyl(C 1 -C 8 -alkyl)amino, C 1 -C 8 -alkylsulfonylamino, C 1 -C 8 -thioalkyl, C 1 -C 8 -alkylsulfinyl, C 1 -C 8 -alkylsulfonyl, aminosulfonyl, C 1 -C 8 -alkylaminosulfonyl or di-C 1 -C 8 -alkylaminosulfonyl groups; R 10  and R 14  independently represent hydroxyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkenyloxy, C 1 -C 4 -alkynyloxy, amino, C 1 -C 8 -alkylamino, di-C 1 -C 8 -alkylamino, C 1 -C 8 -alkylaminocarbonyl, di-C 1 -C 8 -alkylaminocarbonyl, C 1 -C 8 -alkylcarbonylamino, C 1 -C 8 -alkylcarbonyl(C 1 -C 8 -alkyl)amino, C 1 -C 8 -alkylsulfonylamino, an N-linked 5-6 membered heteroaryl group or an N-linked 5-6 membered heterocyclyl, where said cyclic groups may be optionally substituted by one or more hydroxyl, nitro, C 1 -C 8 -alkyl, C 1 -C 8 -alkenyl, C 1 -C 8 -alkynyl, C 1 -C 8 -alkoxy, C 1 -C 8 -alkenyloxy, C 1 -C 8 -alkynyloxy, halogen, C 1 -C 8 -alkylcarbonyl, carboxy, C 1 -C 8 -alkoxycarbonyl, amino, C 1 -C 8 -alkylamino, di-C 1 -C 8 -alkylamino, C 1 -C 8 -alkylaminocarbonyl, di-C 1 -C 8 -alkylaminocarbonyl, C 1 -C 8 -alkylcarbonylamino, C 1 -C 8 -alkylcarbonyl(C 1 -C 8 -alkyl)amino, C 1 -C 8 -alkylsulfonylamino, C 1 -C 8 -thioalkyl, C 1 -C 8 -alkylsulfinyl, C 1 -C 8 -alkylsulfonyl, aminosulfonyl, C 1 -C 8 -alkylaminosulfonyl or di-C 1 -C 8 -alkylaminosulfonyl groups; R 11  and R 13  independently represent hydrogen or C 1 -C 6 -alkyl; R 3  is hydrogen; Y represents the group \u2014N(R 15 )R 16 ; and R 15  and R 16  independently represent hydrogen or C 1 -C 4 -alkyl.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 86.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14261890', '12180969', '12809394', '16060486', '14406848']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8026220190420644
- 35 USC 102 Novelty (BERT): 0.6058571959235005
- Combined Prediction Score: 0.7829455367302081
- Mean Citation Score: 441.36409
- Max Citation Score: 561.0378
- Similarity Product: 448.20594676322935

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test