PATENT CLAIM ANALYSIS

Application Number: 15881919
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "001300"]

Abstract:
This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.

Claim (Index 6):
The compound of  claim 5 , wherein R 11  is:\n (i) \u2014CH 2 OC(\u2550O)R 15 ; (ii) \u2014C(\u2550O)OCH 2 OC(\u2550O)R 15 ; (iii) \u2014SR 15 ; or (iv) \u2014CH 2 Ar\u2014R 15 ; wherein: Ar is C 6-10 aryl, optionally substituted with from 1-3 substituents independently selected from C 1-6 alkyl, C 1-6 alkoxy, and halo; R 15  is C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxyC 1-6 alkyl, C 6-10 aryl, C 7-12 aralkyl, C 3-7 cycloalkyl, heteroaryl including from 5-10 ring atoms (wherein from 1-3 of the ring atoms are independently selected from N, NH, N\u2014C 1 -C 6  alkyl, O, and S), or heterocyclyl including from 3-7 ring atoms (wherein from 1-2 of the ring atoms are independently selected from N, NH, N\u2014C 1 -C 6  alkyl, and O), each of which is optionally substituted; or R 15  is Y n \u2014Z; wherein: Y is a divalent spacer comprising one or more of the following moieties (e.g., comprise 1, 2, 3, 4, or 5 of the following moieties; e.g., comprise 1, 2, or 3 of the following moieties; e.g., consist of 1, 2, 3, 4, or 5 of the following moieties; e.g., consist of 1, 2, or 3 of the following moieties): heteroatom (e.g., N, O, or S), alkylene chain, heteroalkylene chain, C 6-10 arylene, heteroarylene from 5-10 ring atoms (wherein from 1-3 of the ring atoms are independently selected from N, NH, N\u2014C 1 -C 6  alkyl, O, and S), polyheteroalkylene chain, alkenylene chain, \u2014OC(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014NHC(\u2550O)\u2014, \u2014C(\u2550O)NH\u2014, \u2014C(\u2550O)\u2014, cyclodextrin, human serum albumin, amino acid, amino acid mimetic, or hydrazine; Z is conjugate for enhancing solubility, stability, half-life, permeability, volume of distribution, and/or target specificity, which comprises one or more of the following moieties (e.g., comprise 1, 2, 3, 4, or 5 of the following moieties; e.g., comprise 1, 2, or 3 of the following moieties; e.g., consist of 1, 2, 3, 4, or 5 of the following moieties; e.g., consist of 1, 2, or 3 of the following moieties): alkylene chain, heteroalkylene chain, polyheteroalkylene chain, alkenylene chain, cyclodextrin, alkylated cyclodextrin, human serum albumin, \u2014OC(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014NHC(\u2550O)\u2014, \u2014C(\u2550O)NH\u2014, \u2014C(\u2550O)\u2014, monoclonal anti-body, quaternary ammonium ion, NH 2 , docosahexenoic acid, hyaluronic acid, poly(L-glutamic acid), N-(2-hydroxypropyl) methacrylamide copolymer, or dendrimers (e.g., nitro-substituted dendrimers); and n is 0 or 1.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 86.0
- Lexical Diversity: 1.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13938160', '14041953', '15065347', '15602823', '15651687']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7806624912445658
- 35 USC 102 Novelty (BERT): 0.6822569145799692
- Combined Prediction Score: 0.7708219335781061
- Mean Citation Score: 569.07662
- Max Citation Score: 793.8515
- Similarity Product: 648.0551699010134

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test