PATENT CLAIM ANALYSIS

Application Number: 16055921
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["424", "422000"]

Abstract:
A new method of targeted drug administration to wounds (surgical or traumatic), intrasite (IS), offers advantages in treatment efficacy and safety over traditional routes of administration. A novel method of dosing IS medications based on wound surface area provides the parameters for safe and effective dosing, a necessary advance for any FDA approval. Large IS doses increase risk of toxicity from impurities allowed in drugs given by other routes. Methods are presented for ultrapurification, particularly of endotoxins. Methods are presented for sterile delivery to the wound, to prevent aerosolization, and to homogenize application. Pharmacodynamic parameters make certain drugs advantageous as IS agents, including slow trans-wound surface diffusion, protein binding, and limited local tissue toxicity. Vancomycin is a prototypical drug with these features and is therefore very useful as an IS medication. Other drugs, including but not limited to rifaximin, possess similar pharmacodynamics and may be useful IS pharmaceuticals, delivered alone or in combination with other drugs, carriers, or materials. All of these attributes are advantages over traditional administration methods.

Claim (Index 103):
The method of  claim 102 , wherein determining the wound surface area comprises measuring the exposed width, depth, and length of the surgical implant.

Metadata:
- Claim Count in Document: 91.0
- Percentile: 96.0
- Lexical Diversity: 1.68966
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13566816', '15347949', '10500822', '14327192', '12758602']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6939078904645845
- 35 USC 102 Novelty (BERT): 0.502216288441004
- Combined Prediction Score: 0.6747387302622264
- Mean Citation Score: 147.862592
- Max Citation Score: 153.21283
- Similarity Product: 85.85057203390836

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test