PATENT CLAIM ANALYSIS

Application Number: 15941443
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "054000"]

Abstract:
An agent for applying to mucosa capable of persistently exerting a therapeutic effect on disorders such as inflammation and lesions in the mucosa even by a lower frequency of administration because the agent can stay at a diseased site for a long period of time by exhibiting a high staying property in a mucosal epithelial layer is provided, said agent for application to mucosa containing glycosaminoglycan (GAG) into which a hydrophobic group is introduced via a binding chain, as an active ingredient.

Claim (Index 19):
A method for producing an eye drop containing a glycosaminoglycan into which a hydrophobic group is introduced via the spacer chain as an active ingredient, the method comprising:\n introducing the spacer chain and the hydrophobic group to a hyaluronic acid or pharmaceutically acceptable salt thereof, with the proviso that the method not comprising a photodimerization reaction or a photopolymerization reaction to cross link the glycosaminoglycan with one another, wherein the eye drop is liquid preparation in which concentration of the glycosaminoglycan is 0.1 to 0.3% by weight, wherein the glycosaminoglycan having a repeat unit of a structural unit represented by chemical formula (I): wherein, R represents R 1  or R 2 ; Ac represents an acetyl group; R 1  represents ONa or OH; R 2  represents (1) Ph-CH\u2550CH\u2014COO\u2014(CH 2 ) m \u2014NH\u2014; (2) Ph-CH\u2550CH\u2014COO\u2014CH 2 \u2014(OCH 2 ) n \u2014NH\u2014; (3) Ph-CH\u2550CH\u2014CONH\u2014(CH 2 ) m \u2014NH\u2014; (4) Ph-CH\u2550CH\u2014CONH\u2014CH 2 \u2014(OCH 2 )n-NH\u2014; (5) Ph-CH\u2550CH\u2014COO\u2014(CH 2 ) m \u2014O\u2014; (6) Ph-CH\u2550CH\u2014COO\u2014CH 2 \u2014(OCH 2 ) n \u2014O\u2014; (7) Ph-CH\u2550CH\u2014CONH\u2014(CH 2 ) m \u2014O\u2014; or (8) Ph-CH\u2550CH\u2014CONH\u2014CH 2 \u2014(OCH 2 ) n \u2014O\u2014; wherein, Ph represents phenyl group, m and n represent integers of 1 to 18, respectively, and 1 represents 0 or an integer of 1 to 18, as a basic skeleton, wherein the ratio of the above structural unit wherein R represents R 2  is 5 to 30% in molar equivalent relative to the disaccharide repeat unit in molar equivalent of the glycosaminoglycan.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 90.0
- Lexical Diversity: 1.33846
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13070210', '14903817', '15563196', '10548533', '11662087']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6822733843795786
- 35 USC 102 Novelty (BERT): 0.5399749581035634
- Combined Prediction Score: 0.6680435417519772
- Mean Citation Score: 181.319152
- Max Citation Score: 360.2165
- Similarity Product: 264.9601187197864

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test