PATENT CLAIM ANALYSIS

Application Number: 16095640
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["546", "044000"]

Abstract:
The present invention relates to processes useful in the preparation of morphine analogs and derivatives, such as naltrexone, naloxone and nalbuphine and intermediates in the synthesis of said morphine analogs and derivatives. In a particular example, the process begins with for example oxymorphone, oxycodone, 14-hydroxycodeinone or 14-hydroxymorphinone, and includes the formation of an oxazolidine-containing intermediate using catalytic oxidation.

Claim (Index 17):
A process for the preparation of a compound of Formula III, comprising hydrolyzing a compound of Formula I under basic or acidic conditions; to yield the corresponding compound of Formula III; wherein each   represents a single or double bond; provided that two double bonds are not adjacent to each other; R 1  is selected from the group consisting of H, C 1-10 alkyl, C 6-10 aryl, C 3-10 cycloalkyl, C 1-10 alkyleneC 6-10 aryl, C 1-10 alkyleneC 3-10 cycloalkyl and an oxygen protecting group; R 2  is selected from the group consisting of C 1-10 alkyl, C 6-10 aryl, C 3-10 cycloalkyl, C 1-10 alkyleneC 6-10 aryl, C 1-10 alkyleneC 3-10 cycloalkyl and an oxygen protecting group; provided that when \u201c \u201d represents O\u2550, then R 2  is absent; and wherein one or more hydrogen atoms on the R 1  and R 2  groups is optionally replaced with F.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 97.0
- Lexical Diversity: 1.43478
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13462059', '14591382', '16095604', '13264182', '14609612']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7826622098778766
- 35 USC 102 Novelty (BERT): 0.503571929042474
- Combined Prediction Score: 0.7547531817943364
- Mean Citation Score: 279.229752
- Max Citation Score: 290.95157
- Similarity Product: 227.6192158083689

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test