PATENT CLAIM ANALYSIS

Application Number: 16148414
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-03
Patent Classification: ["424", "186100"]

Abstract:
The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.

Claim (Index 19):
A method for producing a vaccine or immunogenic composition, the method comprising:\n (a) transfecting a host cell with a recombinant HSV genome comprising\n (i) a modified UL53 gene comprising a deletion corresponding to the region of the UL53 gene that encodes amino acids 31-68 of wild-type gK; and \n (ii) a modified UL20 gene comprising a deletion corresponding to the region of the UL20 gene that encodes amino acids 4-22 of wild-type UL20 protein; and \n (iii) a gene encoding a foreign antigen; \n wherein a virus comprising the genome is capable of replication in a host cell and incapable of entry into axonal compartments of neurons.\n (b) incubating the transfected host cell under conditions favorable for the formation of a recombinant HSV virus comprising the recombinant HSV genome; \n (c) purifying the recombinant HSV virus comprising the recombinant HSV genome; and optionally \n (d) combining the purified recombinant HSV virus with at least one pharmaceutically acceptable component.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 97.0
- Lexical Diversity: 1.25806
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15310004', '15455495', '12598937', '15928377', '15015322']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7011833766852871
- 35 USC 102 Novelty (BERT): 0.7227050528297483
- Combined Prediction Score: 0.7033355442997332
- Mean Citation Score: 456.33795
- Max Citation Score: 796.5311
- Similarity Product: 762.2295709872722

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test