PATENT CLAIM ANALYSIS

Application Number: 15888455
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["435", "007100"]

Abstract:
The invention provides a method of detecting the presence, absence or severity of a disease in a patient wherein said disease is accompanied by decreased level of S-adenosylmethionine, or increased level of S-adenosylhomocysterine, or reduced methylation index comprising: identifying any individual or a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of SAM in said biological sample using an antibody derived from a hapten analog of SAM, SAH; and correlating the levels of SAM, SAH and MI in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for determining methylation index in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes colloidal gold test strips and homogenous enzyme immunoassays which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

Claim (Index 2):
The method of  claim 1 , wherein said reference profile for screening, diagnosing and monitoring, comprises levels of SAM, SAH and methylation index that are differentially present at a level that is statistically significant, the profile profiling being of at least one of one or more disease, the at least one reference methylation index profile profiling at least one of: one or more disease, cerebrovascular diseases, Parkinson's disease, depression, diabetes, HBP, heart disease, inflammation, kidney disease, liver diseases, pulmonary diseases, lung cancer, liver cancer and other cancers.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 88.0
- Lexical Diversity: 2.08861
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14457099', '14218928', '15164856', '12385749', '10579369']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6623255982373284
- 35 USC 102 Novelty (BERT): 0.5535066201233737
- Combined Prediction Score: 0.651443700425933
- Mean Citation Score: 331.1340380000001
- Max Citation Score: 486.05786
- Similarity Product: 296.5286185551119

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test