PATENT CLAIM ANALYSIS

Application Number: 15942333
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "211080"]

Abstract:
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Claim (Index 33):
The compound of  claim 25 , wherein D is a 5-membered heteroaryl having the formula or a 6-membered heteroaryl having the formula wherein: Q is NR 20 , CR 20 , O or S; each T is independently N or CR 21 ; each Z is independently N or C, provided that only one Z is N; each R 20  and R 21  is independently hydrogen, alkyl, haloalkyl, alkoxy, halogen, hydroxy, or cyano; and R 22  and R 23  are taken together with the atoms to which they are attached to form a bicyclic; wherein the bicyclic may contain one or more heteroatoms selected from N, S and O; and wherein the bicyclic is optionally substituted with one, two, three, four or five R 30 ; wherein each R 30  is independently C 1-6  alkyl, C 2-6  alkenyl, C 3-7  cycloalkyl, C 3-7  heterocyclyl, halogen, cyano, oxo, \u2014NR 31 R 32 , \u2014SO 2 NR 31 R 32 , \u2014C(O)NR 31 R 32 , \u2014C(O)OR 33 , \u2014OR 33 , \u2014NR 33 C(O)R 34 , \u2014NR 33 SO 2 R 35  or \u2014SO 2 R 35 ; wherein the C 1-6  alkyl, C 2-6  alkenyl, C 3-7  cycloalkyl and C 3-7  heterocyclyl of R 30  are optionally substituted with one to four R 40 ; or two R 30  groups are taken together with the parent moiety to with they are attached to form a ring which is optionally substituted with one to four R 40 ; each R 31  and R 32  is independently hydrogen or C 1-6  alkyl; or R 31  and R 32  are taken together with the nitrogen atom to which they are attached to form a C 3-7  heterocyclyl optionally substituted with one to four R 40 ; each R 33  and R 34  are independently hydrogen or C 1-6  alkyl; R 35  is C 1-6  alkyl; each R 40  is independently selected from the group consisting of halogen, cyano, oxo, \u2014NR 41 R 42 , \u2014SO 2 NR 41 R 42 , \u2014C(O)NR 41 R 42 , \u2014C(O)OR 43 , \u2014OR 43 , \u2014NR 43 C(O)R 44 , \u2014NR 43 SO 2 R 45  or \u2014SO 2 R 45 ; C 1-6  alkyl, C 1-6  haloalkyl, C 2-9  heteroaryl, C 6-10  aryl, oxo; or two R 40  groups are taken together with the parent moiety to with they are attached to form a ring which is optionally substituted with one to three substituents selected from C 1-6  alkyl, C 1-6  haloalkyl, hydroxyl and oxo; each R 41  and R 42  is independently hydrogen or C 1-6  alkyl; or R 41  and R 42  are taken together with the nitrogen atom to which they are attached to form a C 3-7  heterocyclyl optionally substituted with one to three substituents selected from C 1-6  alkyl, C 1-6  haloalkyl, hydroxyl and oxo; each R 43  and R 44  are independently hydrogen or C 1-6  alkyl; and R 45  is C 1-6  alkyl.

Metadata:
- Claim Count in Document: 104.0
- Percentile: 90.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15942321', '15698788', '13266976', '15852639', '14428546']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8065002993452961
- 35 USC 102 Novelty (BERT): 0.5300350953332887
- Combined Prediction Score: 0.7788537789440954
- Mean Citation Score: 281.45004400000005
- Max Citation Score: 362.283
- Similarity Product: 321.4770108073354

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test