PATENT CLAIM ANALYSIS

Application Number: 15755356
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "604000"]

Abstract:
Compounds of formula (I) having 1-sulfonamido-4-aryloxy as a basic backbone. A preliminary activity test showed that the compounds provide excellent interference of a binding of Nrf2 by Keap1, thereby activating Nrf2. The compounds have a potential anti-inflammatory activity and can be used to treat a plurality of inflammation-associated diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, gastroenteritis, rheumatoid arthritis, and the like.

Claim (Index 1):
A compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein R 1  represents 4-trifluoromethyl, 4-trifluoromethoxy, 4-nitro, 4-hydroxyl, 4-hydroxymethyl, 4-cyano, 4-amino, H, halo, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylamino, or C1-C3 amido, at occurrence of mono-, di-, or tri-substitution; R 2  represents 4-trifluoromethyl, 4-trifluoromethoxy, 4-nitro, 4-hydroxyl, 4-hydroxymethyl, 4-cyano, 4-amino, 4-morpholinylmethoxy, 4-benzylmethoxy, 4-benzylethoxyl, H, halo, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylamino, or C1-C3 amido, at occurrence of mono-, di-, or tri-substitution; R 3  represents H, \u2014CH 2 COOH, or \u2014CH 2 CONH 2 ; and\n n=0-3.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 88.0
- Lexical Diversity: 1.5082
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['10270259', '09972743', '11909136', '12601284', '15750427']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7265070714487908
- 35 USC 102 Novelty (BERT): 0.4716745819292612
- Combined Prediction Score: 0.7010238224968378
- Mean Citation Score: 164.202382
- Max Citation Score: 167.51404
- Similarity Product: 136.38616450031282

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test