PATENT CLAIM ANALYSIS

Application Number: 16022019
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "063000"]

Abstract:
Augmented or synergized anti-inflammatory constructs are disclosed including anti-inflammatory amino acids covalently conjugated with other anti-inflammatory molecules such as nonsteroidal anti-inflammatory drugs, vanilloids and ketone bodies. Further conjugation with a choline bioisostere or an additional anti-inflammatory moiety further augments the anti-inflammatory activity.

Claim (Index 22):
An anti-inflammatory drug\u2014amino acid conjugate, comprising:\n (a) at least one anti-inflammatory compound conjugated with (b) an augmenting moiety comprising an anti-inflammatory amino acid-choline bioisostere ester or amide, wherein the amino acid is selected from the group consisting of valine, nor-valine, leucine, iso-leucine, glycine, cysteine, proline and phenylalanine; wherein said amino acid-choline bioisostere ester is an amino acid ester of H\u2014OCH 2 CH 2 C(CH 3 ) 3  or H\u2014OCH 2 CH 2 Si(CH 3 ) 3 , and said amino acid-choline bioisostere amide is an amino acid amide of H 2 NCH 2 CH 2 C(CH 3 ) 3  or H 2 NCH 2 CH 2 Si(CH 3 ) 3 ; wherein conjugation of said conjugate is via the nitrogen atom of the amino acid of said augmenting moiety; and wherein the anti-inflammatory activity of the conjugate is greater than the sum of its parts.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 94.0
- Lexical Diversity: 1.21622
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14776857', '14409612', '12706735', '13582487', '13422565']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7171931436932678
- 35 USC 102 Novelty (BERT): 0.5793597753657173
- Combined Prediction Score: 0.7034098068605128
- Mean Citation Score: 292.253476
- Max Citation Score: 500.34738
- Similarity Product: 365.2722661588025

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test