PATENT CLAIM ANALYSIS

Application Number: 15938564
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["435", "377000"]

Abstract:
Human pluripotent stem cells are differentiated in vitro into forebrain subdomain structures, which are then fused to generate an integrated system for use in analysis, screening programs, and the like.

Claim (Index 1):
A method for producing an integrated human forebrain structure in vitro, the method comprising:\n inducing in a pluripotent stem cell suspension culture a neural fate to provide a spheroid of neural progenitor cells; (i) differentiating the neural progenitor cells in a spheroid to differentiate into cortical spheroids (hCS); (ii) differentiating the neural progenitor cells in a spheroid to differentiate into subpallial spheroids (hCS) culturing the hCS and hSS under conditions permissive for cell fusion while maintaining for an extended period of time in neural medium in the absence of growth factors; wherein an integrated forebrain structure is differentiated comprising interacting GABAergic and glutamatergic neurons.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 90.0
- Lexical Diversity: 1.13333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15158408', '14072025', '12674050', '14651346', '13178734']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.577923795857568
- 35 USC 102 Novelty (BERT): 0.5625311325139581
- Combined Prediction Score: 0.5763845295232071
- Mean Citation Score: 329.366664
- Max Citation Score: 444.93274
- Similarity Product: 355.17353541661026

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test