PATENT CLAIM ANALYSIS

Application Number: 15741649
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "450000"]

Abstract:
The disclosure describes a fusogenic liposome-coated porous silicon nanoparticles for high loading efficiency of anionic payloads (small molecules, dyes, nucleic acids), and for non-endocytic delivery of hydrophilic and lipophilic payloads by membrane fusion. The liposome coating can be further modified with targeting peptides or antibodies via covalent binding chemistry between the ligands and functionalized poly(ethylene glycol). The surface moieties can be transferred to the cellular membrane surface by fusogenic uptake. The composition of the disclosure can be applied in the treatment of diseases by delivering entrapped/encapsulated payloads.

Claim (Index 13):
The fusogenic liposome-coated porous silicon nanoparticle of  claim 1 , wherein the fusogenic liposome comprises a mixture of DMPC, DOTAP, and DSPE-PEG (carboxy).

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.45588
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14113371', '15798287', '12909572', '13208902', '15691130']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7399658475322203
- 35 USC 102 Novelty (BERT): 0.5061447208364747
- Combined Prediction Score: 0.7165837348626457
- Mean Citation Score: 257.768008
- Max Citation Score: 271.52148
- Similarity Product: 201.07741184848308

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test