PATENT CLAIM ANALYSIS

Application Number: 16000283
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-05
Patent Classification: ["548", "248000"]

Abstract:
A method for treating a lysophosphatidic acid-dependent disease or condition in a subject in need thereof is provided. The method includes administering to the subject a therapeutically effective amount of a heterocyclic compound. The heterocyclic compound is a lysophosphatidic acid receptor ligand. Lysophosphatidic acid-dependent diseases and conditions include diseases involving fibrosis, such as fibrosis of the heart, kidney, liver and lung, and scleroderma; inflammatory diseases such as diabetic nephropathy and inflammatory bowel disease; ocular diseases such as diseases involving retinal degeneration; nerve diseases such as pruritus and pain.

Claim (Index 17):
A method for treatment of a lysophosphatidic acid-dependent disease or condition in a subject in need thereof, the method comprising:\n administering to the subject a therapeutically effective amount of a compound having the structure of Formula I or a pharmaceutically acceptable salt or prodrug thereof, wherein R A  is \u2014CO 2 H, \u2014CO 2 R B , \u2014CN, tetrazolyl, \u2014C(\u2550O)NH 2 , \u2014C(\u2550O)NHR B , \u2014C(\u2550O)NHSO 2 R B , or \u2014C(\u2550O)NHCH 2 CH 2 SO 3 H or a carboxylic acid isostere selected from the group consisting of wherein R B  is \u2014H or \u2014C 1 -C 4  alkyl or has the structure of one of: L 1  is absent or substituted or unsubstituted C 1 -C 6  alkylene, substituted or unsubstituted C 3 -C 6  cycloalkylene, substituted or unsubstituted C 1 -C 6  fluoroalkylene, or substituted or unsubstituted C 1 -C 6  heteroalkylene; L 2  is absent; Ring B has the structure of: and is substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene, where when Ring B is substituted then Ring B is substituted with 1, 2, or 3 independently selected R H , wherein A 1 , A 2 , and A 3  are independently N or C; Ring A is a 5 membered heteroarene selected from one of: wherein the dashed line indicates the point of attachment of Ring A to Ring B, wherein R C  is \u2014CN, \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014OC 1 -C 4  alkyl, or C 1 -C 4  fluoroalkyl; and R D  is \u2014N(R F )\u2014C(\u2550O)XCH(R G )\u2014CY, \u2014N(R F )C(\u2550O)XC(R G ) 2 \u2014CY, \u2014N(R F )C(\u2550O)X\u2014CY, \u2014C(\u2550O)N(R F )CH(R G )X\u2014CY, or \u2014C(\u2550O)\u2014N(R F )C(R G ) 2 X\u2014CY, wherein X is absent, \u2014O\u2014, \u2014NH\u2014 or \u2014CH 2 \u2014; R E  is \u2014H, \u2014C 1 -C 4  alkyl or \u2014C 1 -C 4  fluoroalkyl; R F  is \u2014H or C 1 -C 4  alkyl; R G  is independently selected from R E , or one R G  is C 1 -C 4  alkyl and is taken together with CY and the carbon atom to which R G  and CY are attached to define a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, and the other R G , when present, is as defined for R E ; CY is substituted or unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 3 -C 10  cycloalkyl, substituted or unsubstituted C 2 -C 10  heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein when CY is substituted then CY is substituted with 1, 2, or 3 independently selected R H ; wherein each R H  is independently selected from \u2014H, halogen, \u2014CN, \u2014NO 2 , \u2014OH, \u2014OR J , \u2014SR J , \u2014S(\u2550O)R J , \u2014S(\u2550O) 2 R J , \u2014N(R J )S(\u2550O) 2 R J , \u2014S(\u2550O) 2 N(R L ) 2 , \u2014C(\u2550O)R J , OC(\u2550O)R J , \u2014C(\u2550O)OR J , \u2014OC(\u2550O)OR J , \u2014N(R L ) 2 , \u2014C(\u2550O)N(R L ) 2 , \u2014OC(\u2550O)N(R L ) 2 , \u2014N(R J )C(\u2550O)N(R L ) 2 , \u2014N(R J )C(\u2550O)R J , \u2014N(R J )C(\u2550O)OR J , C 1 -C 4  alkyl, C 1 -C 4  fluoroalkyl, C 1 -C 4  fluoroalkoxy, C 1 -C 4  alkoxy, and C 1 -C 4  heteroalkyl, wherein each R u  is independently substituted or unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 1 -C 6  heteroalkyl, substituted or unsubstituted C 1 -C 6  fluoroalkyl, substituted or unsubstituted C 3 -C 6  cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014C 1 -C 4  alkylene-(substituted or unsubstituted C 3 -C 6  cycloalkyl), \u2014C 1 -C 4  alkylene-(substituted or unsubstituted heterocycloalkyl), \u2014C 1 -C 4  alkylene-(substituted or unsubstituted aryl), or \u2014C 1 -C 4  alkylene-(substituted or unsubstituted heteroaryl); wherein each R L  is independently \u2014H, substituted or unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 1 -C 6  heteroalkyl, substituted or unsubstituted C 1 -C 6  fluoroalkyl, substituted or unsubstituted C 3 -C 6  cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014C 1 -C 4  alkylene-(substituted or unsubstituted cycloalkyl), \u2014C 1 -C 4  alkylene-(substituted or unsubstituted heterocycloalkyl), \u2014C 1 -C 4  alkylene(substituted or unsubstituted aryl), or \u2014C 1 -C 4  alkylene-(substituted or unsubstituted heteroaryl), or when R H  is \u2014S(\u2550O) 2 N(R L ) 2 , \u2014N(R L ) 2 , \u2014C(\u2550O)N(R L ) 2 , \u2014OC(\u2550O)N(R L ) 2  or N(R J )C(\u2550O)N(R L ) 2 , each R L  is independently \u2014H or C 1 -C 6  alkyl, or the R L  groups independently are C 1 -C 6  alkyl, which are taken together with the N atom to which they are attached to define a substituted or unsubstituted heterocycle; and Ring C is substituted or unsubstituted C 3 -C 10  cycloalkylene, substituted or unsubstituted C 2 -C 10  heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene, where when Ring C is substituted then Ring C is substituted with 1, 2, or 3 independently selected R H , wherein R H  is as previously defined.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 94.0
- Lexical Diversity: 1.73684
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14776954', '13388502', '13992053', '12793440', '13246746']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7384718978699983
- 35 USC 102 Novelty (BERT): 0.598938064698154
- Combined Prediction Score: 0.7245185145528139
- Mean Citation Score: 398.165098
- Max Citation Score: 573.10284
- Similarity Product: 430.5955500039983

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test