PATENT CLAIM ANALYSIS

Application Number: 15938409
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["546", "014000"]

Abstract:
A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK 1  receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

Claim (Index 1):
A method of treating a physiological disorder, symptom or disease, comprising:\n administering to a patient in need thereof an effective amount of at least one compound of formula I: or pharmaceutically acceptable salts and/or solvates thereof, wherein: R 1  and R 2  are each independently selected from the group consisting of H, alkyl, haloalkyl, alkyl substituted with one or more hydroxyl groups, \u2014CN, alkynyl, \u2014N(R 6 ) 2 , \u2014N(R 6 )\u2014S(O 2 )-alkyl, \u2014N(R 6 )\u2014C(O)\u2014N(R 9 ) 2 , -alkylene-CN, -cycloalkylene-CN, -alkylene-O-alkyl, \u2014C(O)-alkyl, \u2014C(\u2550N\u2014OR 5 )-alkyl, \u2014C(O)\u2014N(R 9 ) 2 , \u2014C(O)\u2014O-alkyl, -alkylene-C(O)-alkyl, -alkylene-C(O)\u2014O-alkyl, -alkylene-C(O)\u2014N(R 9 ) 2 , with the proviso that at least one of R 1  and R 2  is \u2014CN, W is \u2550C(R 8 )\u2014 or \u2550N\u2014; X is \u2014C(O)\u2014 or \u2014S(O 2 )\u2014; Y is selected from the group consisting of \u2014CH 2 \u2014, \u2014O\u2014, and \u2014N(R 6 )\u2014C(O)\u2014, with the proviso that: (a) the nitrogen atom of \u2014N(R 6 )\u2014C(O)\u2014 is bonded to X, and (b) if R 1  and/or R 2  is and Y is \u2014O\u2014, X is not \u2014S(O 2 )\u2014;\n Z is \u2014C(R 7 ) 2 \u2014, \u2014N(R 6 )\u2014, or \u2014O\u2014; \n R 3  is selected from the group consisting of H, \u2014CH 2 OR 5 , and alkyl; \n R 4  is selected from the group consisting of H, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl, aryl, acyl, aroyl, alkylsulfonyl, and arylsulfonyl; \n R 5  is H or alkyl; \n R 6  is selected from the group consisting of H, alkyl, cycloalkyl, and aryl; \n each R 7  is independently H or alkyl; or \n each R 7 , together with the ring carbon to which they are shown attached, form a cycloalkylene ring; \n R 8  is selected from the group consisting of H, alkyl, alkyl substituted with one or more hydroxyl groups, \u2014N(R 6 ) 2 , \u2014N(R 6 )\u2014S(O 2 )-alkyl, \u2014N(R 6 )\u2014S(O 2 )-aryl, \u2014N(R 6 )\u2014C(O)-alkyl, \u2014N(R 6 )\u2014C(O)-aryl, alkylene-O-alkyl, and \u2014CN; \n R 9  is selected from the group consisting of H, alkyl, and aryl, or each R 9 , together with the nitrogen to which they are shown attached, form a heterocycloalkyl ring; \n Ar 1  and Ar 2  are each independently selected from the group consisting of unsubstituted aryl and aryl substituted with 0 to 3 substituents selected from the group consisting of halogen, alkyl, alkoxy, haloalkyl, haloalkoxy, \u2014CN, \u2014OH, and \u2014NO 2 ; \n n is 0, 1, or 2; and \n m is 1, 2, or 3, \n wherein the physiological disorder, symptom or disease is selected from the group consisting of respiratory diseases, inflammatory diseases, skin disorders, ophthalmalogical disorders, central nervous system conditions, depression, anxiety, phobia, bipolar disorder, addictions, alcohol dependence, psychoactive substance abuse, epilepsy, nociception, psychosis, schizophrenia, Alzheimer's disease, AIDS related dementia, Towne's disease, stress related disorders, obsessive/compulsive disorders, eating disorders, bulimia, anorexia nervosa, binge eating, sleep disorders, mania, premenstrual syndrome, gastrointestinal disorders, atherosclerosis, fibrosing disorders, obesity, Type II diabetes, pain related disorders, headache, neuropathic pain, post-operative pain, chronic pain syndrome, bladder disorders or genitourinary disorders.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.19048
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13245403', '12750420', '11432133', '11653558', '10741056']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8123108216065469
- 35 USC 102 Novelty (BERT): 0.5245942578010923
- Combined Prediction Score: 0.7835391652260014
- Mean Citation Score: 343.390956
- Max Citation Score: 362.47183
- Similarity Product: 333.86762480943327

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test