PATENT CLAIM ANALYSIS

Application Number: 16106997
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["514", "04400A"]

Abstract:
The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides small interfering RNAs (siRNAs) having modification that enhance the stability of the siRNA without a concomitant loss in the ability of the siRNA to participate in RNA interference (RNAi). The invention also provides siRNAs having modification that increase targeting efficiency. Modifications include chemical crosslinking between the two complementary strands of an siRNA and chemical modification of a 3′ terminus of a strand of an siRNA. Preferred modifications are internal modifications, for example, sugar modification, nucleobase modification and/or backbone modifications. Such modifications are also useful, e.g., to improve uptake of the siRNA by a cell. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.

Claim (Index 40):
A method of activating target-specific RNA interference (RNAi) in a cell or organism comprising introducing into said cell or organism the siRNA of  claim 1 , said siRNA being introduced in an amount sufficient for degradation of target mRNA to occur, thereby activating target-specific RNAi in the cell.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 96.0
- Lexical Diversity: 1.88158
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14661810', '13561357', '14294817', '13654199', '10912440']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8261218292840291
- 35 USC 102 Novelty (BERT): 0.669678245724432
- Combined Prediction Score: 0.8104774709280694
- Mean Citation Score: 575.40515
- Max Citation Score: 810.7073
- Similarity Product: 626.4615186118008

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test