PATENT CLAIM ANALYSIS

Application Number: 15921442
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "123000"]

Abstract:
Methods of producing peptide beta-lactones and beta-hydroxy acids are disclosed that include contacting a beta-hydroxy-alpha-amino acid, an aryl carrier protein (ObiD), and ATP with a non-ribosomal protein synthetase. A continuous flow reactor is disclosed that includes an elongate conduit with at least one region that includes a first region with a non-ribosomal protein synthetase immobilized to a substrate. The non-ribosomal protein synthetase of the continuous flow reactor is configured to contact a flow of a reaction mixture that includes a beta-hydroxy-alpha-amino acid and an aryl carrier protein. The non-ribosomal protein synthetase is further configured to release a peptide beta-lactone into the flow of the reaction mixture.

Claim (Index 11):
The method of  claim 7 , further comprising forming the beta-hydroxy-alpha-amino acid in the reaction mixture by contacting an aliphatic or aryl aldehyde or derivative thereof, an amino acid, and a pyridoxyl phosphate (PLP) cofactor with a serine hydroxymethyltransferase/threonine aldoloase, wherein:\n the aliphatic or aryl aldehyde or derivative thereof is selected from the group consisting of aliphatic aldehydes, aromatic benzaldehydes, aromatic phenylacetaldehydes, and aromatic cinnamaldehydes the amino acid is selected from the group consisting of threonine, serine, glycine, and any isomer thereof; the serine hydroxymethyltransferase/threonine aldoloase is selected from the group consisting of ObiH, a homolog of ObiH, and any variation thereof comprising the amino acid sequence of SEQ ID NO:3 or fragment thereof; and the reaction mixture further comprises the aliphatic or aryl aldehyde or derivative thereof, the amino acid and the serine hydroxymethyltransferase/threonine aldoloase and the pyridoxyl phosphate (PLP) cofactor.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 2.07273
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12842549', '12118362', '10925357', '11775216', '10017324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.532734706713321
- 35 USC 102 Novelty (BERT): 0.5058839505245547
- Combined Prediction Score: 0.5300496310944444
- Mean Citation Score: 208.44705400000004
- Max Citation Score: 260.4539
- Similarity Product: 190.2577970833004

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test