PATENT CLAIM ANALYSIS

Application Number: 16307491
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["435", "007100"]

Abstract:
The invention relates to diagnostics, namely to a reagent kit, a rapid method and a device for detecting the fact of chronic, ischemia-linked brain pathology. A special feature of the invention is the use of an immunoactive hybrid peptide produced as a product of two fragments of the NMDA neuroreceptor subunits. A device is described that allows quick and convenient testing of autoantibodies in the patient's blood that recognize the hybrid peptide. The method of detection of autoantibodies is based on the principle of lateral flow immunochromatography. The invention can be used for prophylactic medical examination (screening of chronic ischemia-linked brain lesions), to detect decompensated chronic cerebral ischemia at the prehospital stage by general practitioners or neurologists, as well as in neurosurgery and sports medicine for diagnostics of delayed cerebral ischemia in persons with craniocerebral injury.

Claim (Index 1):
A reagent kit for aiding in diagnosis of a chronic, ischemia-linked brain pathology in a mammal, comprising:\n a) a hybrid peptide having at least 90% identity over its entire length with the sequence SEQ ID NO:1, wherein the hybrid peptide is immobilized on a solid carrier; b) a reagent for determining the presence of autoantibodies to said hybrid peptide in a biological fluid of the mammal, wherein the reagent has an specific binding affinity for mammalian immunoglobulins.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 98.0
- Lexical Diversity: 1.63736
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11076074', '11339440', '11339452', '14749408', '13190271']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5853607988560584
- 35 USC 102 Novelty (BERT): 0.4895734281347361
- Combined Prediction Score: 0.5757820617839262
- Mean Citation Score: 211.692382
- Max Citation Score: 218.2418
- Similarity Product: 153.67850630689858

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test