PATENT CLAIM ANALYSIS

Application Number: 15751792
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-10
Patent Classification: ["530", "388100"]

Abstract:
A method for separating cells capable of producing target antigen-specific monoclonal antibodies (TASMAs) wherein a cell group including antibody-producing cells is immobilized using a reversible crosslinking agent having cell membrane-permeating properties. The immobilized cell group is subjected to cell membrane dissolution using a surface active agent; and the cell group is reacted with a labeling target antigen. In the stained cell group a that has reacted with the labeling target antigen is separated. A method to produce TASMAs by separating mRNA from the cell separated using the method; preparing cDNA and preparing antigen-specific monoclonal antibodies or fragments thereof from the prepared cDNA. Also provided are a method whereby at least one cell capable of producing TASMAs is separated and a method whereby said antibodies can be produced by using the separated cell. Threonine 18 phosphorylated p53 (pT18-p53) and threonine 68 phosphorylated CHK2 (pT68-CHK2) specific monoclonal antibodies are also disclosed.

Claim (Index 19):
The monoclonal antibody as claimed in  claim 17  having a gamma chain comprising a variable region having an amino acid sequence as shown in SEQ ID NO: 17 and a kappa chain comprising a variable region having an amino acid sequence as shown in SEQ ID NO: 18.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 88.0
- Lexical Diversity: 1.96386
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13425538', '15042106', '14787478', '10338366', '15361936']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.633026046005532
- 35 USC 102 Novelty (BERT): 0.5162307223749066
- Combined Prediction Score: 0.6213465136424695
- Mean Citation Score: 284.8170320000001
- Max Citation Score: 292.74838
- Similarity Product: 207.6700816109956

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test