PATENT CLAIM ANALYSIS

Application Number: 15927636
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "510000"]

Abstract:
The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

Claim (Index 29):
A method of treating a medical condition responsive to treatment with treprostinil, comprising administering to a subject in need of treatment a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof: wherein R 1  and R 2  independently are hydrogen, \u2003wherein:\n R 3  in each occurrence independently is alkyl, -alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which may optionally be substituted; \n R 4  and R 5  in each occurrence independently are hydrogen, C 1 -C 6  alkyl or C 3 -C 6  cycloalkyl, or R 4  and R 5  and the carbon atom to which they are connected form a C 3 -C 6  cycloalkyl ring; \n R 6  in each occurrence independently is hydrogen, R 3 , \u2014C(\u2550O)R 3 , \u2014C(\u2550O)OR 3  or \u2014C(\u2550O)NR 9 R 10 ; or\n R 6  and R 4  or R 5 , together with the atoms to which they are connected, form a heterocyclic ring; \n \n R 9  and R 10  in each occurrence independently are hydrogen, alkyl, -alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl; or\n R 9  and R 10  and the nitrogen atom to which they are connected form a heterocyclic or heteroaryl ring; \n \n j in each occurrence independently is an integer from 0 to 4; and \n m in each occurrence independently is an integer from 1 to 10; \n with the proviso that:\n both R 1  and R 2  are not hydrogen; \n neither \u2014OR 1  nor \u2014OR 2  forms an acetate; \n neither \u2014OR 1  nor \u2014OR 2  forms a substituted cyclohexane-ester; and \n neither \u2014OR 1  nor \u2014OR 2  forms an ester with or of an amino acid (protected or unprotected), a peptide or a protein.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 90.0
- Lexical Diversity: 1.42857
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15617243', '14742544', '15178637', '15473434', '14829180']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7653044841319391
- 35 USC 102 Novelty (BERT): 0.489046005941079
- Combined Prediction Score: 0.7376786363128531
- Mean Citation Score: 244.71725
- Max Citation Score: 251.23091
- Similarity Product: 210.16416228569508

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test