PATENT CLAIM ANALYSIS

Application Number: 16204566
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["540", "519000"]

Abstract:
The present invention relates to certain diaryl inacrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Claim (Index 57):
A compound of the following Formula (I-A): wherein\n Ring A\u2032 and Ring B\u2032 are each independently a monocyclic or bicyclic aryl or heteroaryl; wherein one of Ring A\u2032 and Ring B\u2032 is a monocyclic aryl or heteroaryl and the other is a bicyclic heteroaryl; and at least one of Ring A\u2032 and Ring B\u2032 comprises at least one nitrogen ring member; provided that B\u2032 is not of the formula \n each L 1  and L 2  is independently \u2014C(R 1 \u2032)(R 2 \u2032)\u2014, \u2014O\u2014, \u2014S\u2014, \u2014S(O)\u2014 or \u2014S(O)2\u2014; each R 1 \u2032 and R 2 \u2032 are independently H, deuterium, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, or mono- or bicyclic heteroaryl, \u2014OR a \u2032, \u2014OC(O)R a \u2032, \u2014OC(O)NR a \u2032R b \u2032, \u2014OS(O)R a \u2032, \u2014OS(O) 2 R a \u2032, \u2014SR a \u2032, \u2014S(O)R a \u2032, \u2014S(O) 2 R a \u2032, \u2014S(O)NR a \u2032R b \u2032, \u2014S(O) 2 NR a \u2032R b \u2032, \u2014OS(O)NR a \u2032R b \u2032, \u2014OS(O) 2 NR a \u2032R b \u2032, \u2014NR a \u2032R b \u2032, \u2014NR a \u2032C(O)R b \u2032, \u2014NR a \u2032C(O)OR b \u2032, \u2014NR a \u2032C(O)NR a \u2032R b \u2032, \u2014NR a \u2032S(O)R b \u2032, \u2014NR a \u2032S(O) 2 R b \u2032, \u2014NR a \u2032S(O)NR a \u2032R b \u2032, \u2014NR a \u2032S(O) 2 NR a \u2032R b \u2032, \u2014C(O)R a \u2032, \u2014C(O)OR a \u2032, \u2014C(O)NR a \u2032R b \u2032, \u2014PR a \u2032R b \u2032, \u2014P(O)R a \u2032R b \u2032, \u2014P(O) 2 R a \u2032R b \u2032, \u2014P(O)NR a \u2032R b \u2032, \u2014P(O) 2 NR a \u2032R b \u2032, \u2014P(O)OR a \u2032, \u2014P(O) 2 OR a \u2032, \u2014CN, or \u2014NO 2 , or R 1 \u2032 and R 2 \u2032 taken together with the carbon or carbons to which they are attached form a C 3-6 cycloalkyl or a 4- to 6-membered heterocycloalkyl, wherein each hydrogen atom in C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, mono- or bicyclic heteroaryl, 4- to 6-membered heterocycloalkyl is independently optionally substituted by deuterium, halogen, C 1-6 alkyl, C 1-6 haloalkyl, \u2014OR c \u2032, \u2014OC(O)R c \u2032, \u2014OC(O)NR e \u2032R f \u2032, \u2014OS(O)R e \u2032, \u2014OS(O) 2 R e \u2032, \u2014OS(O)NR e \u2032R f \u2032, \u2014OS(O) 2 NR e \u2032R f \u2032, \u2014SR e \u2032, \u2014S(O)R e \u2032, \u2014S(O) 2 R e \u2032, \u2014S(O)NR e \u2032R f \u2032, \u2014S(O) 2 NR e \u2032R f \u2032, \u2014NR e \u2032R f \u2032, \u2014NR e \u2032C(O)R f \u2032, \u2014NR e \u2032C(O)OR f \u2032, \u2014NR e \u2032C(O)NR e \u2032R f , \u2014NR e \u2032S(O)R f \u2032, \u2014NR e \u2032S(O) 2 R f \u2014, \u2014NR e \u2032S(O)NR e \u2032R f \u2032, \u2014NR e \u2032S(O) 2 NR e \u2032R f \u2032, \u2014C(O)R c \u2032, \u2014C(O)OR c \u2032, \u2014C(O)NR c \u2032R f \u2032, \u2014PR c \u2032R f \u2032, \u2014P(O)R c \u2032R f \u2032, \u2014P(O) 2 R c \u2032R f \u2032, \u2014P(O)NR c \u2032R f \u2032, \u2014P(O) 2 NR e \u2032R f \u2032, \u2014P(O)OR e \u2032, \u2014P(O) 2 OR e \u2032, \u2014CN, or \u2014NO 2 ; each R k \u2032 is independently H, deuterium, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10 aryl, or mono- or bicyclic heteroaryl, wherein each hydrogen atom in C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, or mono- or bicyclic heteroaryl is independently optionally substituted by deuterium, halogen, C 1-6 alkyl, C 1-6 haloalkyl, \u2014OR e \u2032, \u2014OC(O)R e \u2032, \u2014OC(O)NR e \u2032R f \u2032, \u2014OS(O)R e \u2032, \u2014OS(O) 2 R e \u2032, \u2014OS(O)NR e \u2032R f \u2032, \u2014OS(O) 2 NR e \u2032R f \u2032, \u2014SR e \u2032, \u2014S(O)R e \u2032, \u2014S(O) 2 R e \u2032, \u2014S(O)NR e \u2032R f \u2032, \u2014S(O) 2 NR e \u2032R f \u2032, \u2014NR e \u2032R f \u2032, \u2014NR e \u2032C(O)R f \u2032, \u2014NR e \u2032C(O)OR f \u2032, \u2014NR e \u2032C(O)NR e \u2032R f \u2032, \u2014NR e \u2032S(O)R f \u2032, \u2014NR e \u2032S(O) 2 R f \u2032, \u2014NR e \u2032S(O)NR e \u2032R f \u2032, \u2014NR e \u2032S(O) 2 NR e \u2032R f \u2032, \u2014C(O)R e \u2032, \u2014C(O)OR e \u2032, \u2014C(O)NR e \u2032R f \u2032, \u2014PR e \u2032R f \u2032, \u2014P(O)R e \u2032R f \u2032, \u2014P(O) 2 R e \u2032R f \u2032, \u2014P(O)NR e \u2032R f \u2032, \u2014P(O) 2 NR e \u2032R f \u2032, \u2014P(O)OR e \u2032, \u2014P(O) 2 OR e \u2032, \u2014CN, or \u2014NO 2 ; each R 3 \u2032 and R 4 \u2032 is independently deuterium, halogen, \u2014OR c \u2032, \u2014OC(O)R c \u2032, \u2014OC(O)NR c \u2032R d \u2032, \u2014OC(\u2550N)NR c \u2032R d \u2032, \u2014OS(O)R e \u2032, \u2014OS(O) 2 R c \u2032, \u2014OS(O)NR c \u2032R d \u2032, \u2014OS(O) 2 NR c \u2032R d \u2032, \u2014SR c \u2032, \u2014S(O)R c \u2032, \u2014S(O) 2 R c \u2032, \u2014S(O)NR c \u2032R d \u2032, \u2014S(O) 2 NR c \u2032R d \u2032, \u2014NR c \u2032C(O)R d \u2032, \u2014NR c \u2032C(O)OR d \u2032, \u2014NR c \u2032C(O)NR c \u2032R d \u2032, \u2014NR c \u2032C(\u2550N)NR c \u2032R d \u2032, \u2014NR c \u2032S(O)R d \u2032, \u2014NR c \u2032S(O) 2 R d \u2032, \u2014NR c \u2032S(O)NR c \u2032R d \u2032, \u2014NR c \u2032S(O) 2 NR c \u2032R d \u2032, \u2014C(O)R c \u2032, \u2014C(O)OR c \u2032, \u2014C(O)NR c \u2032R d \u2032, \u2014C(\u2550N)NR c \u2032R d \u2032, \u2014PR c \u2032R d \u2032, \u2014P(O)R c \u2032R d \u2032, \u2014P(O) 2 R c \u2032R d \u2032, \u2014P(O)NR c \u2032R d \u2032, \u2014P(O) 2 NR c \u2032R d \u2032, \u2014P(O)OR c \u2032,  13  P(O) 2 OR c \u2032, \u2014CN, \u2014NO 2 , C 16 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, or mono- or bicyclic heteroaryl, or any two R 3 \u2032 groups or any two R 4 \u2032 groups taken together with the ring to which they are attached form a C 5-8 cycloalkyl or a 5- to 8-membered heterocycloalkyl, wherein each hydrogen atom in C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, mono- or bicyclic heteroaryl C 5-8 cycloalkyl or a 5- to 8-membered heterocycloalkyl is independently optionally substituted by deuterium, halogen, C 1-6 alkyl, C 1-6 haloalkyl, \u2014OR e \u2032, \u2014OC(O)R e \u2032, \u2014OC(O)NR e \u2032R f \u2032, \u2014OS(O)R e \u2032, \u2014OS(O) 2 R e \u2032, \u2014OS(O)NR e \u2032R f \u2032, \u2014OS(O) 2 NR e \u2032R f \u2032, \u2014SR e \u2032, \u2014S(O)R e \u2032, \u2014S(O) 2 R e \u2032, \u2014S(O)NR e \u2032R f \u2032, \u2014S(O) 2 NR e \u2032R f \u2032, \u2014NR e \u2032R f \u2032, \u2014NR e \u2032C(O)R f \u2032, \u2014NR e \u2032C(O)OR f \u2032, \u2014NR e \u2032C(O)NR e \u2032R f \u2032, \u2014NR e \u2032S(O)R f \u2032, \u2014NR e \u2032S(O) 2 R f \u2032, \u2014NR e \u2032S(O)NR e \u2032R f \u2032, \u2014NR e \u2032S(O) 2 NR e \u2032R f \u2032, \u2014C(O)R e \u2032, \u2014C(O)OR e \u2032, \u2014C(O)NR e \u2032R f \u2032, \u2014PR e \u2032R f \u2032, \u2014P(O)R e \u2032R f , \u2014P(O) 2 R e \u2032R f \u2032, \u2014P(O)NR e \u2032R f \u2032, \u2014P(O) 2 NR e \u2032R f \u2032, \u2014P(O)OR e \u2032, \u2014P(O) 2 OR e \u2032, \u2014CN, or \u2014NO 2 ; R 7 \u2032 is H, deuterium, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, or mono- or bicyclic heteroaryl, wherein each hydrogen atom in C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, or mono- or bicyclic heteroaryl is independently optionally substituted by deuterium, halogen, \u2014OR i \u2032, \u2014OC(O)R i \u2032, \u2014OC(O)NR i \u2032R j \u2032, \u2014OS(O)R i \u2032, \u2014OS(O) 2 R i \u2032, \u2014OS(O)NR i \u2032R j \u2032, \u2014OS(O) 2 NR i \u2032R j \u2032, \u2014S(O)R i \u2032, \u2014S(O) 2 R i \u2032, \u2014S(O) 2 NR i \u2032R j \u2032, \u2014NR i \u2032R j \u2032, \u2014NR i \u2032C(O)R j \u2032, \u2014NR i \u2032C(O)OR j \u2032, \u2014NR i \u2032C(O)NR i \u2032R j \u2032, \u2014NR i \u2032S(O)R j \u2032, \u2014NR i \u2032S(O) 2 R j \u2032, \u2014NR i \u2032S(O)NR i \u2032R j \u2032, \u2014NR i \u2032S(O) 2 NR i \u2032R j \u2032, \u2014C(O)R i \u2032, \u2014C(O)OR i \u2032, \u2014C(O)NR i \u2032R j \u2032, \u2014PR i \u2032R j \u2032, \u2014P(O)R i \u2032R j \u2032, \u2014P(O) 2 R i \u2032R j \u2032, \u2014P(O)NR i \u2032R j \u2032, \u2014P(O) 2 NR i \u2032R j \u2032, \u2014P(O)OR i \u2032, \u2014P(O) 2 OR i \u2032, \u2014CN, or \u2014NO 2 ; each R a \u2032, R b \u2032, R c \u2032, R d \u2032, R e \u2032, R f \u2032, R i \u2032 and R j \u2032 is independently selected from the group consisting of H, deuterium, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 3- to 7-membered heterocycloalkyl, C 6-10  aryl, and heteroaryl; m\u2032 is 2, 3, 4, or 5; n\u2032 is 2, 3, or 4; p\u2032 is 0, 1, 2, 3, or 4; and q\u2032 is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 98.0
- Lexical Diversity: 1.35714
- Patent Class: 540.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15609962', '15113583', '15740462', '16320589', '14397200']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7630289134972896
- 35 USC 102 Novelty (BERT): 0.6185756196537192
- Combined Prediction Score: 0.7485835841129327
- Mean Citation Score: 526.013384
- Max Citation Score: 617.3812
- Similarity Product: 474.4189792152644

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test