PATENT CLAIM ANALYSIS

Application Number: 15747571
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting a xanthine dehydrogenase (XDH) gene, and methods of using such double stranded RNAi agents to inhibit expression of an XDH gene and methods of treating subjects having an XDH-associated disease.

Claim (Index 79):
A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of a xanthine dehydrogenase (XDH) gene in a cell,\n wherein said dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region, wherein said sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:1 and said antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:2, wherein substantially all of the nucleotides of said sense strand comprise a modification selected from the group consisting of a 2\u2032-O-methyl modification and a 2\u2032-fluoro modification, wherein said sense strand comprises two phosphorothioate internucleotide linkages at the 5\u2032-terminus, wherein substantially all of the nucleotides of said antisense strand comprise a nucleotide modification selected from the group consisting of a 2\u2032-O-methyl modification and a 2\u2032-fluoro modification, wherein said antisense strand comprises two phosphorothioate internucleotide linkages at the 5\u2032-terminus and two phosphorothioate internucleotide linkages at the 3\u2032-terminus, and wherein said sense strand is conjugated to one or more GalNAc derivatives attached through a branched bivalent or trivalent linker at the 3\u2032-terminus.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 86.0
- Lexical Diversity: 1.51515
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14976261', '15670132', '14947025', '15399820', '14650128']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8241919926636052
- 35 USC 102 Novelty (BERT): 0.5531977733018567
- Combined Prediction Score: 0.7970925707274303
- Mean Citation Score: 382.727662
- Max Citation Score: 405.0581
- Similarity Product: 376.4530416912735

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test