PATENT CLAIM ANALYSIS

Application Number: 15774223
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["424", "233100"]

Abstract:
Compositions and methods are provided for modulating adeno-associated virus (AAV) infection. For example, compositions and methods are provided for enhancing permissiveness of a target cell to AAV infection (e.g., by increasing levels of AAVR (KIAA0319L) in the cell), for reducing permissiveness of a target cell to AAV infection (e.g., by reducing levels of AAVR in the cell), and for nucleic acid delivery (e.g., by (i) increasing permissiveness of a target cell to AAV infection, e.g., by increasing the amount of AAVR in the cell; and (ii) contacting the target cell with an AAV particle that includes a nucleic acid of interest). Also provided are screening methods and kits for practicing the methods of the disclosure.

Claim (Index 88):
A method of identifying an agent that enhances or reduces the permissiveness of cells to adeno-associated virus (AAV) infection, comprising:\n (i) assaying one or more target protein characteristics selected from: the amount of target protein present on the cell surface, the amount of target protein present in the trans golgi network (TGN) of the cell, and total target protein expression level; and (ii) determining that a genetic modification of a cell of said library:\n (a) increases the amount of target protein present on the cell surface, increased the amount of target protein present in the trans golgi network (TGN) of the cell, and/or increased total target protein expression level, wherein the method further comprises determining that the genetic modification of the cell is an AAV permissiveness-enhancing genetic modification, or \n (b) decreases the amount of target protein present on the cell surface, decreased the amount of target protein present in the trans golgi network (TGN) of the cell, and/or decreased total target protein expression level, wherein the method further comprises determining that the genetic modification of the cell is an AAV permissiveness-reducing genetic modification, \n wherein the target protein is selected from: adeno-associated virus receptor (AAVR) (KIAA0319L), GPR108, and TM9SF2.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 93.0
- Lexical Diversity: 2.66038
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10880297', '15367734', '15681267', '15435212', '13840224']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6982118211818085
- 35 USC 102 Novelty (BERT): 0.5249428582699801
- Combined Prediction Score: 0.6808849248906257
- Mean Citation Score: 312.9323080000001
- Max Citation Score: 317.23126
- Similarity Product: 226.9475964929545

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test