PATENT CLAIM ANALYSIS

Application Number: 15745461
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["548", "255000"]

Abstract:
The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those routes.

Claim (Index 23):
The method of  claim 17 , wherein the process for preparing Compound (VI) further comprises:\n combining zinc bromide and the solvent, wherein the solvent is selected from the group consisting of: N,N-dimethylformamide, N,N-dimethylacetamide, tetrahydrofuran, diisopropyl ether, toluene, anisole, t-butylmethyl ether, diethyl ether, 1,4-dioxane, 1,2-dimethoxyethane, N-methylpyrrolidone, and dimethylsulfoxide; adding 4-bromopyridine hydrochloride, triphenylphosphine, and palladium (II) chloride while maintaining the batch temperature between about 0\u00b0 C. about 25\u00b0 C.; further adding triethylamine and trimethylsilylacetylene while maintaining the batch temperature between about 0\u00b0 C. about 25\u00b0 C.; combining the reaction mixture with hexanes, and treating the reaction mixture with NH 4 OH; washing an organic phase of the reaction mixture first with NH 4 OH and then with water; neutralizing the organic phase with an acid; drying the organic phase, and concentrating to a slurry; combining the slurry with hexanes to give a precipitate; filtering the precipitate out of the slurry and concentrating a filtrate; and distilling the filtrate to produce Compound (VI).

Metadata:
- Claim Count in Document: 108.0
- Percentile: 86.0
- Lexical Diversity: 1.125
- Patent Class: 548.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14853883', '14946137', '15355630', '15841828', '13889980']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7274333538625978
- 35 USC 102 Novelty (BERT): 0.495947894806223
- Combined Prediction Score: 0.7042848079569604
- Mean Citation Score: 216.948504
- Max Citation Score: 220.2003
- Similarity Product: 158.97453726021052

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test