PATENT CLAIM ANALYSIS

Application Number: 15746590
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-03
Patent Classification: ["424", "133100"]

Abstract:
The present invention relates to humanized antibodies that specifically bind to human transferrin receptor and their use in treating cancer and inflammatory disorders.

Claim (Index 15):
A process for the production of an anti-TfR antibody or a protein of  claim 1 , comprising: (i) culturing a host cell comprising a cloning or expression vector for the recombinant production of an anti-TfR antibody comprising either,\n (a) a variable heavy chain polypeptide comprising HCDR1 of SEQ ID NO:1, HCDR2 of SEQ ID NO:2, HCDR3 of SEQ ID NO:3 and a variable light chain polypeptide comprising LCDR1 of SEQ ID NO:4, LCDR2 of SEQ ID NO:5 and LCDR3 of SEQ ID NO:6; (b) a variable heavy chain polypeptide comprising HCDR1 of SEQ ID NO:1, HCDR2 of SEQ ID NO:2, HCDR3 of SEQ ID NO:3 and a variable light chain polypeptide comprising LCDR1 of SEQ ID NO:4, LCDR2 of SEQ ID NO:8 and LCDR3 of SEQ ID NO:6; (c) a variable heavy chain polypeptide comprising VH of SEQ ID NO:11 and a variable light chain polypeptide comprising VL of SEQ ID NO:13; (d) a variable heavy chain polypeptide comprising VH of SEQ ID NO:11 and a variable light chain polypeptide comprising VL of SEQ ID NO:14; (e) a variable heavy chain polypeptide comprising VH of SEQ ID NO:11 and a variable light chain polypeptide comprising VL of SEQ ID NO:15; (f) a variable heavy chain polypeptide comprising VH of SEQ ID NO:12 and a variable light chain polypeptide comprising VL of SEQ ID NO:13; (g) a variable heavy chain polypeptide comprising VH of SEQ ID NO:12 and a variable light chain polypeptide comprising VL of SEQ ID NO:14; (h) a variable heavy chain polypeptide comprising VH of SEQ ID NO:12 and a variable light chain polypeptide comprising VL of SEQ ID NO:15; wherein said anti-TfR antibody or protein specifically binds to the transferrin receptor (TfR) of SEQ ID NO: 16 for expression of said antibody or protein by the host cell; optionally (ii) purifying said antibody or protein; and, (iii) recovering said antibody or protein.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.09091
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14116714', '14283038', '13916379', '14441307', '14958053']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7003266055163193
- 35 USC 102 Novelty (BERT): 0.5298665442726938
- Combined Prediction Score: 0.6832805993919567
- Mean Citation Score: 324.06234
- Max Citation Score: 333.03397
- Similarity Product: 230.7310509524709

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test