PATENT CLAIM ANALYSIS

Application Number: 16160804
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["514", "04400A"]

Abstract:
This document relates to methods and materials involved in modulating deubiquitinases (e.g., USP10 polypeptides) and/or ubiquitinated polypeptides (e.g., tumor suppressor polypeptides or mutant versions of tumor suppressor polypeptides). For example, methods and materials for increasing deubiquitinase (e.g., a USP10 polypeptide) expression or activity, methods and materials for decreasing deubiquitinase (e.g., a USP10 polypeptide) expression or activity, methods and materials for stabilizing tumor suppressor polypeptides (e.g., wild-type p53 polypeptides), methods and materials for de-stabilizing mutant versions of tumor suppressor polypeptides (e.g., mutant p53 polypeptides), and methods and materials for reducing cancer cell proliferation, increasing cancer cell apoptosis, and/or treating cancer (e.g., cancers having reduced levels of wild-type p53 polypeptides or cancers having increased levels of mutant p53 polypeptides) are provided. This document also provides methods and materials for identifying agonists or antagonists of USP10 polypeptide mediated stabilization of p53 polypeptides.

Claim (Index 1):
A method for reducing cancer cell proliferation in a mammal having cancer cells, wherein said method comprises administering a composition to said mammal under conditions wherein said composition modulates USP10 polypeptide expression or activity within said cancer cells, thereby reducing cancer cell proliferation.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 2.83333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13394786', '14956635', '12731374', '11786399', '14694793']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.815438630932598
- 35 USC 102 Novelty (BERT): 0.65874279550395
- Combined Prediction Score: 0.7997690473897333
- Mean Citation Score: 443.124488
- Max Citation Score: 683.3381
- Similarity Product: 600.1580617901802

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test