PATENT CLAIM ANALYSIS

Application Number: 15976630
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["424", "278100"]

Abstract:
Provided herein are novel therapeutic compositions and methods that keep cellular immunotherapies in the circulation or at the site of injection for extended periods of time without resorting to the use of cytotoxic preconditioning. More specifically the compositions and methods herein lymphodeplete and reduce or ablate sites in the secondary lymphatics where the cellular immunotherapy is bound and sequestered, without the use of cytotoxic preconditioning.

Claim (Index 1):
A method of enhancing adoptive cellular therapy (ACT) in a patient, the method comprising: identifying a patient suffering from a disease selected from the group consisting of cancer, autoimmune disease, and infection; administering to the patient a non-toxic lymphodepleting agent (NTLA) at a dose that is effective to cause substantial lymphodepletion and/or cause ablation of secondary lymphatic germinal centers, administering ACT to the patient, wherein the ACT comprises either a cell used to enhance the immune system in treating a disease in said patient or a cell derived from an immune lineage which directly treats said disease, and wherein the method does not include the administration of radiotherapy nor a chemotherapeutic agent for a duration of more than 1 day within about 2 weeks preceding the start of ACT administration.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 1.51111
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15649369', '15167977', '13708014', '12721645', '14661656']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6723376824963082
- 35 USC 102 Novelty (BERT): 0.5145827766900563
- Combined Prediction Score: 0.656562191915683
- Mean Citation Score: 272.19344199999995
- Max Citation Score: 285.63626
- Similarity Product: 184.5617732777297

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test