PATENT CLAIM ANALYSIS

Application Number: 15875015
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "009300"]

Abstract:
This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.

Claim (Index 86):
A method for treating rheumatoid arthritis in a human subject, comprising:\n intravenously administering to a subject in need thereof a pharmaceutical composition comprising a N-(2-hydroxypropyl) methacrylamide copolymer and a physiologically acceptable carrier, wherein said N-(2-hydroxypropyl)methacrylamide copolymer consists of N-(2-hydroxypropyl)methacrylamide and N-methacryloyl glycylglycyl hydrazone glucocorticoid or a pharmaceutically acceptable salt thereof, wherein the glucocorticoid is dexamethasone, and wherein the pharmaceutically acceptable salt is dexamethasone palmitate.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.41935
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10591258', '12389193', '13537537', '14671790', '15644945']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6708505238204466
- 35 USC 102 Novelty (BERT): 0.6634904431600932
- Combined Prediction Score: 0.6701145157544113
- Mean Citation Score: 333.967794
- Max Citation Score: 682.01904
- Similarity Product: 614.1236320690728

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test