PATENT CLAIM ANALYSIS

Application Number: 16270231
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-05
Patent Classification: ["424", "136100"]

Abstract:
The invention concerns isolated polyspecific antibodies directed to a unique epitope in the chemokine eotaxin 2, whereby the antibodies bind additional CCR3-binding chemokines. The invention further concerns use of these antibodies for attenuating the migration of various cells and for treating fibrotic diseases, autoimmune inflammatory disorders, monocyte related disorders or allergic atopic disorders.

Claim (Index 31):
An isolated antibody that binds a conformational epitope in the N-loop region of a CCR3-binding chemokine, wherein said conformational epitope is characterized by a relatively high concentration of positive amino acid residues located between amino acid positions 14 and 24 in the amino acid sequence of said CCR3-binding chemokine and wherein said antibody is a fully humanized antibody comprising a heavy chain variable region comprising:\n a) the complementary determining region VH CDR1 comprising the amino acid sequence denoted by SEQ ID NO. 5 or an amino acid sequence with at least 90% sequence identity with SEQ ID NO. 5; b) the complementary determining region VH CDR2 comprising the amino acid sequence denoted by SEQ ID NO. 6 or an amino acid sequence with at least 90% sequence identity with SEQ ID NO. 6; and c) the complementary determining region VH CDR3 comprising the amino acid sequence denoted by SEQ ID NO. 7 or an amino acid sequence with at least 90% sequence identity with SEQ ID NO. 7; and a light chain variable region comprising d) the complementary determining region VK CDR1 comprising the amino acid sequence denoted by SEQ ID NO. 8 or an amino acid sequence with at least 90% sequence identity with SEQ ID NO. 8; e) the complementary determining region VK CDR2 comprising the amino acid sequence denoted by SEQ ID NO. 9 or an amino acid sequence with at least 90% sequence identity with SEQ ID NO. 9; and f) the complementary determining region VK CDR3 comprising the amino acid sequence denoted by SEQ ID NO. 10 or an amino acid sequence with at least 90% sequence identity with SEQ ID NO. 10.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 99.0
- Lexical Diversity: 1.31818
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15122241', '13146711', '08963656', '11216610', '10283028']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7087487653956731
- 35 USC 102 Novelty (BERT): 0.607547003143644
- Combined Prediction Score: 0.6986285891704702
- Mean Citation Score: 363.717174
- Max Citation Score: 566.102
- Similarity Product: 458.5680293080807

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test