PATENT CLAIM ANALYSIS

Application Number: 16286955
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "211100"]

Abstract:
Compounds having the formula I wherein R 1 , X 1 , X 2 , X 3  and X 4  as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

Claim (Index 1):
A compound of formula I: or a pharmaceutically acceptable salt thereof; wherein X 1  is N or CH; X 2  is O; X 3  is C(R 4 ) 2 ; X 4  is CR 2 R 3 ; R 1  is (i) a 4 to 7 membered saturated or partially unsaturated heterocyclyl containing an oxygen atom; or, (ii) a heteroaryl selected from the group consisting of 1-methyl-1H-pyrazol-4-yl, 1-methyl-1H-pyrazol-3-yl, 2-ethyl-2H-pyrazol-3-yl, 2-methyl-2H-pyrazol-3-yl, 2-isopropyl-2H-pyrazol-3-yl, 1-methyl-1H-pyrazol-5-yl, 1-ethyl-1H-pyrazol-5-yl, 4-methylthiazol-2-yl, 1-methyl-1H-[1,2,4]triazol-3-yl, 2-methyl-2H-[1,2,3]-triazol-4-yl, 1-methyl-1H-[1,2,4]-triazol-5-yl, 1,3-dimethyl-1H-pyrazol-4-yl, 1,3,5-trimethyl-1H-pyrazol-4-yl, 1-methyl-1H-tetrazol-5-yl, 2-methyl-2H-tetrazol-5-yl, 5-methyl-1,3,4-thiadizol-2-yl, oxetan-3-yl, 3-methyloxetan-3-yl, tetrahydropyran-4-yl, tetrahydro-2H-pyran-4-yl, tetrahydropyran-3-yl, 2-methyl-tetrahydropyran-4-yl, 2,2-dimethyl-tetrahydropyran-4-yl, 2-hydroxymethyltetrahydropyran-4-yl, 3-fluorotetrahydropyran-4-yl and tetrahydrofuran-3-yl; R 2  is selected from the group consisting of: (a) C 1-10  alkyl, (b) C 2-10  alkenyl, (c) C 1-10  haloalkyl, (d) C 3-7  cycloalkyl or C 3-7  cycloalkyl-C 1-6  alkyl, (e) C 3-7  halocycloalkyl or C 3-7  halocycloalkyl-C 1-6  alkyl, (f) C 1-10  hydroxyalkyl or C 1-10  dihydroxyalkyl, (g) C 1-3  alkoxy-C 1-6  alkyl, (h) C 1-3  alkylthio-C 1-6  alkyl, (i) C 1-10  cyanoalkyl, (j) phenyl, phenyl-C 1-3  alkyl, phenoxy or benzyloxy-C 1-3  alkyl, (k) heteroaryl, heteroaryl-C 1-3  alkyl or heteroaryloxy wherein said heteroaryl moiety is selected from the group consisting of pyrazolyl, imidiazolyl, oxazolyl, isoazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrid-2(1H)-one and 1-alkylpyrid-2(1H)-one and each said heteroaryl is independently optionally substituted with one or more groups selected from the group consisting of halogen, hydroxyl, oxide, C 1-6  alkoxy, C 1-6  haloalkoxy, cyano, C 3-6  cycloalkyl and C 1-6  alkyl wherein said C 1-6  alkyl is optionally independently substituted with one or more groups independently selected from halogen, oxo, hydroxyl or C 1-6  alkoxy; and (l) phenylthio or phenylthio-C 1-6  alkyl; R 3  and R 4  are independently hydrogen or C 1-3  alkyl; and R a  is hydrogen or C 1-3  alkyl; wherein any phenyl moiety is optionally substituted one or more halogen, cyano, hydroxyl, C 1-6  alkoxy, C 1-6  haloalkoxy or C 1-6  alkyl wherein said C 1-6  alkyl is optionally independently substituted with one or more groups independently selected from halogen, oxo, hydroxyl or C 1-6  alkoxy; and, wherein each cycloalkyl is independently and optionally substituted with one to three groups selected from halogen, C 1-6  haloalkyl, C 1-6  alkoxy and C 1-6  haloalkoxy.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 99.0
- Lexical Diversity: 1.29032
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15705104', '14559786', '14568153', '13503083', '11890199']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.815027047401142
- 35 USC 102 Novelty (BERT): 0.7015756374598593
- Combined Prediction Score: 0.8036819064070136
- Mean Citation Score: 499.559878
- Max Citation Score: 726.9046599999997
- Similarity Product: 716.8170325671074

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test