PATENT CLAIM ANALYSIS

Application Number: 16198815
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["530", "303000"]

Abstract:
An insulin analogue comprises a B-chain polypeptide containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid substitutions at positions A8, B28, and/or B29. A proinsulin analogue or single-chain insulin analogue contains a B domain containing a cyclohexanylalanine substitution at position B24 and optionally contains additional amino-acid substitutions at positions A8, B28, and/or B29. The analogue may be an analogue of a mammalian insulin, such as human insulin. A nucleic acid encoding such an insulin analogue is also provided. A method of lowering the blood sugar of a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. A method of semi-synthesis using an unprotected octapeptide by means of modification of an endogenous tryptic site by non-standard amino-acid substitutions.

Claim (Index 2):
The insulin analogue of  claim 1 , additionally comprising a substitution at position B29 selected from the group consisting of norleucine, aminobutyric acid, aminopropionic acid, ornithine, diaminobutyric acid, and diaminopropionic acid.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 98.0
- Lexical Diversity: 1.97222
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14232496', '15277319', '14416022', '14762712', '12884943']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7870827154299785
- 35 USC 102 Novelty (BERT): 0.6582250266853572
- Combined Prediction Score: 0.7741969465555164
- Mean Citation Score: 612.38885
- Max Citation Score: 656.0268599999997
- Similarity Product: 637.1012937860511

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test