PATENT CLAIM ANALYSIS

Application Number: 16312063
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "248000"]

Abstract:
Provided are certain compounds or pharmaceutically acceptable salts thereof which can inhibit kinase activity of Bruton's tyrosine kinase (BTK) and may be useful for the treatment of diseases like cancer, immunological disease and inflammation.

Claim (Index 25):
A compound selected from\n 3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, 7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, 3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, 7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(3-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(4-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,3-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,55-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(3,5-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(3-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(4-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,3-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(3,5-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(3-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(4-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2,3-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(3,5-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(3-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(4-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2,3-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(3,5-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(3-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(4-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,3-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(3,5-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(3-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(4-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,3-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(3,5-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(3-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(4-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2,3-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(3,5-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(3-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(4-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2,3-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-3-(1-acryloylpiperidin-3-yl)-7-amino-1-(4-(3,5-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,55-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-7-amino-3-(1-(but-2-ynoyl)piperidin-3-yl)-1-(4-(2,6-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (R)-4-(7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyridazin-1-yl)-N-(pyridin-2-yl)benzamide, (R)-4-(3-(1-acryloylpyrrolidin-3-yl)-7-amino-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyridazin-1-yl)-N-(pyridin-2-yl)benzamide, (S,E)-7-amino-3-(1-(4-methoxybut-2-enoyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S,E)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-3-(1-(4-methoxybut-2-enoyl)pyrrolidin-3-yl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S,E)-7-amino-3-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S,E)-7-amino-3-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-azetidin-2-yl)acryloyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-azetidin-2-yl)acryloyl)pyrrolidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-azetidin-2-yl)acryloyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-1-(4-(2-fluorophenoxy)phenyl)-3-((S)-1-((E)-3-((R)-1-methylazetidin-2-yl)acryloyl)pyrrolidin-3-yl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-1-ethylazetidin-2-yl)acryloyl)pyrrolidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-1-ethyl azetidin-2-yl)acryloyl)pyrrolidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S,E)-7-amino-3-(1-(4-methoxybut-2-enoyl)piperidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S,E)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-3-(1-(4-methoxybut-2-enoyl)piperidin-3-yl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S,E)-7-amino-3-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S,E)-7-amino-3-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-azetidin-2-yl)acryloyl)piperidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-azetidin-2-yl)acryloyl)piperidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-1-methylazetidin-2-yl)acryloyl)piperidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-1-(4-(2-fluorophenoxy)phenyl)-3-((S)-1-((E)-3-((R)-1-methylazetidin-2-yl)acryloyl)piperidin-3-yl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-1-ethylazetidin-2-yl)acryloyl)piperidin-3-yl)-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 7-amino-3-((S)-1-((E)-3-((R)-1-ethyl azetidin-2-yl)acryloyl)piperidin-3-yl)-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 3-(1-acryloylazetidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 3-(1-acryloylpiperidin-4-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 3-(1-acryloylpiperidin-4-yl)-7-amino-1-(4-(2-fluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, 3-(1-acryloylazetidin-3-yl)-7-amino-1-(4-phenoxyphenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2,5-difluorophenoxy)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-3-(1-acryloylpyrrolidin-3-yl)-7-amino-1-(4-(2-fluorophenoxy-3-d)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, (S)-7-amino-3-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1-(4-(2-fluorophenoxy-3-d)phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin-4-one, and pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 98.0
- Lexical Diversity: 1.08333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15763095', '12598912', '14418484', '13859569', '15676852']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8251446720298262
- 35 USC 102 Novelty (BERT): 0.5472155881327329
- Combined Prediction Score: 0.7973517636401168
- Mean Citation Score: 406.030806
- Max Citation Score: 412.5569
- Similarity Product: 308.15176597123144

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- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test