PATENT CLAIM ANALYSIS

Application Number: 16072347
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "075000"]

Abstract:
Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound are described.

Claim (Index 6):
A payload-ligand conjugate compound comprising a cell-specific targeting ligand conjugated to a payload wherein said conjugate comprises the formula wherein\n V is selected from O and S; \n W is selected from a bivalent, straight or branched, saturated or unsaturated, optionally substituted C1-30 hydrocarbon chain wherein one or more methylene units are optionally and independently replaced by \u2014O\u2014, \u2014S\u2014, \u2014N(R)\u2014, \u2014C(O)\u2014, C(O)O\u2014, OC(O)\u2014, \u2014N(R)C(O)\u2014, \u2014C(O)N(R)\u2014, \u2014S(O)\u2014, \u2014S(O) 2 \u2014, \u2014N(R)SO 2 \u2014, SO 2 N(R)\u2014, a heterocyclic group, an aryl group, or a heteroaryl group; \n X is selected from a covalent bond; a carbon atom; a heteroatom; an optionally substituted group selected from the group consisting of acyl, aliphatic, heteroaliphatic, aryl, heteroaryl, and heterocyclic; nucleoside, protease sensitive group, cathepsin B sensitive group, or glycosidase sensitive group; \n Y is selected from a covalent bond or a bivalent, straight or branched, saturated or unsaturated, optionally substituted C 1-30  hydrocarbon chain wherein one or more methylene units are optionally and independently replaced by \u2014O\u2014, \u2014S\u2014, \u2014N(R)\u2014, \u2014C(O)\u2014, C(O)O\u2014, OC(O)\u2014, \u2014N(R)C(O)\u2014, \u2014C(O)N(R)\u2014, \u2014S(O)\u2014, \u2014S(O) 2 \u2014, \u2014N(R)SO 2 \u2014, SO 2 N(R)\u2014, a heterocyclic group, an aryl group, or a heteroaryl group; \n D is a payload; \n Z is a linkage formed between (i) a reactive functional group selected from the group consisting of N-hydroxysuccinimide, para-nitrophenyl carbonate, para-nitrophenyl carbamate, pentafluorophenyl, haloacetamide, maleimide, hydroxylamine, strained cycloalkyne, and heterocycloalkyne, alkyne, diene, azadiene, and heterocyclic azadience, wherein halo is iodine (I), bromine (Br), fluorine (F), or chlorine (Cl) and hetero is N, O, or S, and (ii) an S, NR, or O group on the cell-specific targeting ligand (L); \n Each occurrence of R is independently hydrogen, a suitable protecting group, an acyl moiety, arylalkyl moiety, aliphatic moiety, aryl moiety, heteroaryl moiety, or heteroaliphatic moiety; \n L is a cell-specific targeting ligand; and \n n is 1, 2, 3, or 4.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 95.0
- Lexical Diversity: 1.07692
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15301564', '13984423', '14843520', '12681052', '13145531']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7400357578958605
- 35 USC 102 Novelty (BERT): 0.5553959320528371
- Combined Prediction Score: 0.7215717753115581
- Mean Citation Score: 305.880966
- Max Citation Score: 439.15353
- Similarity Product: 326.32139752530463

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test