PATENT CLAIM ANALYSIS

Application Number: 15885275
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "547000"]

Abstract:
The disclosure provides methods of treating cancer in a subject or preventing a relapse or reducing the incidence of relapse of cancer in a subject in remission, comprising administering to the subject: (a) a therapeutically effective amount of an immunotherapeutic agent, e.g., an immune checkpoint blockade therapy, an adoptive cellular therapy, a marrow-infiltrating lymphocytes, an adenosine A2aR inhibitor, or an antibody; and (b) a compound having formula (I): and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 2′ , and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON).

Claim (Index 20):
A method of preventing a relapse or reducing the incidence of relapse of a cancer subject in remission, the method comprising administering to the subject in need thereof a compound, or a pharmaceutically acceptable salt thereof, having formula (I): wherein:\n X is selected from the group consisting of a bond, \u2014O\u2014, and \u2014(CH 2 )\u2014, wherein n is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, and 8; \n R 1  is selected from the group consisting of C 1-6  alkyl and substituted C 1-6  alkyl; \n R 2  is an amino acid, an N-substituted amino acid, or \u2014C(\u2550O)\u2014O\u2014(CR 3 R 4 ) m \u2014O\u2014C(\u2550O)\u2014R 10 ; \n R 2\u2032  is selected from the group consisting of H, C 1 -C 6  alkyl, and substituted C 1 -C 6  alkyl; \n each R 3  and R 4  are independently H, C 1 -C 6  alkyl, substituted C 1 -C 6  alkyl, aryl, substituted aryl, \u2014(CR 3 R 4 ) m \u2014NR 5 R 6 , or \n m is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, and 8; R 5  and R 6  are independently H or alkyl; and R 10  is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, monosaccharide, acylated monosaccharide, aryl, substituted aryl, heteroaryl, and substituted heteroaryl.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 86.0
- Lexical Diversity: 1.77333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15885147', '15885258', '15419642', '15263033', '15705200']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7068975313040126
- 35 USC 102 Novelty (BERT): 0.5722731610275694
- Combined Prediction Score: 0.6934350942763683
- Mean Citation Score: 331.8535720000001
- Max Citation Score: 479.74307000000016
- Similarity Product: 344.46881837924843

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test