PATENT CLAIM ANALYSIS

Application Number: 16153273
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-03
Patent Classification: ["435", "004000"]

Abstract:
Compositions and Methods for Stabilizing Circulating Tumor Cells Methods and compositions for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, especially blood, the biological sample including at least one circulating tumor cell from the subject. The methods may include a step of contacting the biological sample with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.

Claim (Index 1):
A method for blood sample treatment comprising:\n locating a protective agent into a tube, the protective agent including imidazolidinyl urea and EDTA; drawing a blood sample having a first circulating tumor cell concentration into the tube, whereby the blood sample contacts the protective agent; isolating circulating tumor cells from the contacted sample after the blood draw, the contacted blood sample having a second circulating tumor cell concentration, wherein the second circulating tumor cell concentration is not lower or higher than the first circulating tumor cell concentration by any statistically significant value; and\n wherein the concentration of the imidazolidinyl urea after the contacting step is greater than 5 mg/ml; \n wherein the protective agent is present in an amount that is less than about 5% of an overall mixture volume of the protective agent and the drawn blood sample.

Metadata:
- Claim Count in Document: 49.0
- Percentile: 97.0
- Lexical Diversity: 1.76364
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14907167', '12553733', '12704030', '15120502', '13511536']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5668624282562591
- 35 USC 102 Novelty (BERT): 0.5648773409864098
- Combined Prediction Score: 0.5666639195292742
- Mean Citation Score: 278.433732
- Max Citation Score: 465.6651
- Similarity Product: 381.1797945164859

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test