PATENT CLAIM ANALYSIS

Application Number: 15986727
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "476000"]

Abstract:
In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a toxin including an acylfulvene or a drug moiety. The affinity moiety can be an antibody, a binding protein, a steroid, a lipid, a growth factor, a protein, a peptide or non peptidic. The affinity moiety can be covalently bound to the medicant via a linker. Novel linkers that can be directed to cysteine, arginine or lysine residues based on solution pH allow greater flexibility in preserving and/or generating specific epitopes in the AMC.

Claim (Index 2):
The compound of  claim 1 , where \u2014X\u2014 is selected from the group consisting of \u2014NH\u2014, \u2014NR 8 \u2014, \u2014S\u2014, \u2014O\u2014, \u2014R 8 C\u2550CR 9 \u2014, \u2014NR 8 \u2014, \u2014CHR 8 \u2014, \u2014CR 8 R 9 \u2014, \u2014OC(\u2550O)O\u2014, \u2014OC(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014CR 8 (\u2550N)\u2014, \u2014CR 8 (\u2550N)NR 9 \u2014, \u2014CR 8 (\u2550N)NR 9 S(\u2550O) 2 \u2014, \u2014CR 8 (\u2550N)O\u2014, \u2014N(OR 8 )\u2014, \u2014C(C\u2550O)NR 8 \u2014, \u2014N(OR 8 )C(\u2550O)\u2014, \u2014N(OR 8 )C(\u2550O)NR 9 \u2014, \u2014N(R 8 )S\u2014, \u2014N(R 8 )S(\u2550O)\u2014, \u2014N(R 8 )S(\u2550O) 2 \u2014, \u2014OC(\u2550O)NR 8 \u2014, \u2014N(OR 8 )C(\u2550O)O\u2014, \u2014N(R 8 )C(\u2550S)\u2014, \u2014O(S(\u2550O) 2 \u2014, \u2014O(S(\u2550O) 2 NR 8 \u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 \u2014, \u2014N(R 8 )S(\u2550O) 2 NR 9 \u2014, \u2014NR 8 (C\u2550O)\u2014, \u2014NR 8 (C\u2550O)O\u2014, \u2014NR 8 (C\u2550O)N\u2014, \u2014N(\u2550N)\u2014, and \u2014CR 8 (\u2550N\u2014N\u2550)CR 9 \u2014, where R 8 , R 9  each independently represent \u2014H, \u2014OH, \u2014OCH 3 , \u2014OC(\u2550O)CH 3 , \u2014CH 3 , \u2014CH 2 \u2014CH 3 , \u2014CH\u2014(CH 3 ) 2 , \u2014C(CH 3 ) 3 , \u2014CH 2 \u2014CH 2 \u2014CH 3 , \u2014CH 2 \u2014CH\u2014(CH 3 ) 2 , \u2014CH\u2014C\u2014(CH 3 ) 3 , \u2014C(\u2550O)CH 3 , \u2014CH 2 OH, and \u2014(C 1 -C 4 )alkyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 1.66176
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15201301', '14684218', '14875476', '13397205', '11342937']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8493121826994495
- 35 USC 102 Novelty (BERT): 0.6278972369764398
- Combined Prediction Score: 0.8271706881271486
- Mean Citation Score: 491.007214
- Max Citation Score: 758.3846
- Similarity Product: 510.1298718908668

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test