PATENT CLAIM ANALYSIS

Application Number: 15777219
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "266230"]

Abstract:
The invention relates to octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof. Compounds and pharmaceutical compositions comprising the compounds provided herein are used for antagonizing orexin receptors. The invention also relates to processes for preparing the compounds and pharmaceutical compositions, and uses thereof in treating or preventing a disease related to orexin receptors.

Claim (Index 1):
A compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein, X is \u2014O\u2014, \u2014S\u2014, \u2014NH\u2014, *\u2014CR 9 \u2550N\u2014 or *\u2014CR 9 \u2550CR 9a \u2014, wherein * refers to an end attached to the benzene ring; Hy is triazolyl, and wherein the triazolyl is optionally substituted by one or more substituents independently selected from halogen, oxo (\u2550O), C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy and benzyl; each R 1 , R 2 , R 3 , R 4 , R 9  and R 9a  is independently H, D, \u2014CD 3 , \u2014CN, \u2014NH 2 , \u2014OH, \u2014NO 2 , \u2014COOH, \u2014C(\u2550O)NH 2 , halogen, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylamino, C 1-6  hydroxy-substituted alkyl, (C 1-6  alkyl)-C(\u2550O)\u2014, (C 1-6  alkoxy)-C(\u2550O)\u2014, (C 1-6  alkylamino)-C(\u2550O)\u2014, cycloalkyl, heterocyclyl, aryl or heteroaryl; each of R 5  and R 6  is independently H, D, F, Cl, Br, I, \u2014CN, \u2014NH 2 , \u2014OH, \u2014NO 2 , \u2014COOH, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylamino, C 1-6  hydroxy-substituted alkyl, (C 1-6  alkyl)-C(\u2550O)\u2014, (C 1-6  alkoxy)-C(\u2550O)\u2014, (C 1-6  alkylamino)-C(\u2550O)\u2014, cycloalkyl, heterocyclyl, aryl or heteroaryl; R 7  is H, D, F, Cl, Br, I, \u2014CN, \u2014NH 2 , \u2014OH, \u2014NO 2 , \u2014COOH, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 2-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylamino, C 1-6  hydroxy-substituted alkyl, (C 1-6  alkyl)-C(\u2550O)\u2014, (C 1-6 alkoxy)-C(\u2550O)\u2014, (C 1-6  alkylamino)-C(\u2550O)\u2014, cycloalkyl, heterocyclyl, aryl or heteroaryl; and R 8  is H, D, Cl, Br, I, \u2014CN, \u2014NH 2 , \u2014OH, \u2014NO 2 , \u2014COOH, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylamino, C 1-6  hydroxy-substituted alkyl, (C 1-6  alkyl)-C(\u2550O)\u2014, (C 1-6  alkoxy)-C(\u2550O)\u2014, (C 1-6  alkylamino)-C(\u2550O)\u2014, cycloalkyl, heterocyclyl, aryl or heteroaryl; when X is \u2014O\u2014, at least one of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7  and R 8  is not H.

Metadata:
- Claim Count in Document: 18.0
- Percentile: 93.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14774702', '15745437', '14787774', '15314932', '15257926']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.815716875137039
- 35 USC 102 Novelty (BERT): 0.5311800754634985
- Combined Prediction Score: 0.787263195169685
- Mean Citation Score: 346.824786
- Max Citation Score: 356.4972
- Similarity Product: 254.0176970471621

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test