PATENT CLAIM ANALYSIS

Application Number: 16007825
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "401000"]

Abstract:
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.

Claim (Index 1):
A method of increasing life expectancy of a test subject,\n wherein the test subject is a non-human mammal that has a transgene in its genome that contains a tissue-specific promoter sequence controlling expression of a polypeptide so as to cause said polypeptide to be expressed selectively in senescent cells in the test subject; wherein contacting senescent cells in the subject that express the polypeptide with a particular small molecule compound results in selective elimination of at least some of the senescent cells; wherein the method comprises administering said compound to the subject so as to selectively eliminate senescent cells in the subject, thereby increasing the life expectancy of the subject.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 94.0
- Lexical Diversity: 1.63462
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15981696', '15455684', '15955542', '16007880', '15827539']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8590984097347416
- 35 USC 102 Novelty (BERT): 0.5930911545885998
- Combined Prediction Score: 0.8324976842201275
- Mean Citation Score: 572.9718799999997
- Max Citation Score: 579.3641
- Similarity Product: 424.99765342518685

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test