PATENT CLAIM ANALYSIS

Application Number: 15979128
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "236200"]

Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).

Claim (Index 13):
The compound of  claim 1 , selected from the compounds set forth below or a pharmaceutically acceptable salt thereof: Compound Structure \u20021a   \u20022a   \u20023a   \u20024a   \u20025a   \u20026a   \u20027a   \u20028a   \u20029a   10a   11a   12a   13a   14a   15a   16a   17a   18a   19a   20a   21a   22a   23a   24a   25a   26a   27a   28a   29a   30a   31a   32a   33a   34a   35a   36a   37a   38a   39a   40a   41a   42a   43a   44a   45a   46a   47a   48a   49a   50a   51a   52a   53a   54a   55a   56a   57a   58a   59a   60a   61a   \u20021b   \u20022b   \u20023b   \u20024b   \u20025b   \u20026b   \u20021c   \u20022c   \u20023c   \u20024c

Metadata:
- Claim Count in Document: 44.0
- Percentile: 93.0
- Lexical Diversity: 1.84416
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12974622', '15724919', '16063542', '14670421', '15597417']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7856369539854795
- 35 USC 102 Novelty (BERT): 0.5205941795570097
- Combined Prediction Score: 0.7591326765426326
- Mean Citation Score: 304.51726799999994
- Max Citation Score: 310.5816700000001
- Similarity Product: 225.4252785270769

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test