PATENT CLAIM ANALYSIS

Application Number: 15971025
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["424", "186100"]

Abstract:
The present disclosure provides fusion proteins that incorporate unique mechanisms for multimerizing antigens to enhance their immunogenicity. The fusion proteins comprise at least two antigens, or other vaccine related proteins, separated by a linker sequence and an oligomerization domain. When expressed, the fusion protein forms a muKimeric protein complex, This approach can be used to muHimeri?.e a single antigen/protein or to create multimers comprising two or more different antigens/proteins. Also provided are nucleic acids encoding the fusion proteins. Yet another aspect is directed to methods of inducing or suppressing an immune response in a subject by administering to the subject a vaccine composition comprising a fusion protein or nucleic acid encoding the fusion protein, optionally without using an adjuvant.

Claim (Index 1):
A fusion protein comprising a first antigen, a linker sequence, a second antigen, and an oligomerization domain, wherein the linker sequence joins the first antigen to the second antigen and wherein the fusion protein does not include a tetanus toxoid protein, wherein the first and second antigens are viral antigens or bacterial antigens.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 93.0
- Lexical Diversity: 1.54118
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14416780', '11089426', '15558942', '09621268', '13946313']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7447799753711764
- 35 USC 102 Novelty (BERT): 0.6479262642949172
- Combined Prediction Score: 0.7350946042635504
- Mean Citation Score: 407.746226
- Max Citation Score: 735.53503
- Similarity Product: 574.221828084712

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test