PATENT CLAIM ANALYSIS

Application Number: 15876645
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "054000"]

Abstract:
Manufactured hyaluronic acid products are used in numerous surgical applications including viscoelastic supplementation for the treatment of osteoarthritis; however, traditional sterilization techniques result in the breakdown of such high molecular o weight viscoelastic biopolymers and are thus unsuitable. Disclosed are processes for obtaining concentrated sterile solutions of high molecular weight biopolymers such as hyaluronic acid. The processes include filter sterilization with a dilute preparation of the biopolymer, and concentration of the dilute filter sterilized biopolymer by ultrafiltration to a desired concentration.

Claim (Index 1):
A process for formulating hyaluronic acid, the process comprising:\n (i) dissolving bulk-manufactured hyaluronic acid having a high molecular weight of 3.0\u00b10.6 megadaltons in an aqueous medium to form a hyaluronic acid solution having a concentration of less than 0.2%; (ii) sterile-filtering the hyaluronic acid solution having a concentration of less than 0.2% by passage through a membrane suitable for sterile filtration at a pressure that does not adversely affect the high molecular weight of the hyaluronic acid, whereby the sterile-filtering retains the high molecular weight structure of the hyaluronic acid in the hyaluronic acid solution; and (iii) subsequently concentrating the sterile-filtered hyaluronic acid by ultrafiltration with a membrane having a pore size of 0.002 to 0.1 microns under aseptic conditions to form a sterile solution formulation of a desired final concentration; wherein the formulation is suitable for medicinal use by injection into a human without further purification following step (iii); and wherein the concentrated hyaluronic acid in the sterile solution formulation has a high molecular weight of 3.0\u00b10.6 megadaltons.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 86.0
- Lexical Diversity: 1.52632
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14023196', '10523657', '10955084', '12887017', '12702540']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.736769725431451
- 35 USC 102 Novelty (BERT): 0.5599725679897544
- Combined Prediction Score: 0.7190900096872814
- Mean Citation Score: 242.782942
- Max Citation Score: 444.5891
- Similarity Product: 342.094731347692

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test