PATENT CLAIM ANALYSIS

Application Number: 16379559
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["424", "009100"]

Abstract:
The present subject matter is directed to a method of manufacturing and purifying an intravenous injection of prothrombin complex concentration (PCC) from plasma Fraction III and a method of manufacturing and purifying an intravenous injection of non-PCC from plasma Fraction IV. The intravenous injection of PCC and non-PCC obtained from the method can be administered to a patient in need thereof for stopping replication, killing and preventing HIV-1 and HIV-2 in a patient.

Claim (Index 1):
A method of manufacturing and purifying an intravenous injection of prothrombin complex concentration (PCC) from plasma Fraction III, comprising the steps:\n a) reconstituting a Fraction III paste in a buffer to create a Fraction III suspension; b) adjusting pH and temperature of the Fraction III suspension; c) performing PEG precipitation of the Fraction III suspension; d) centrifuging the Fraction III suspension and collecting a supernatant; e) filtering the supernatant with a 10CP+90SP filter; f) performing solvent detergent virus inactivation of the supernatant; g) undergoing weak anion exchange chromatography of the supernatant; h) twice washing the supernatant and eluting two to three times; i) ultra-filtering the supernatant with a 10K membrane; j) adjusting pH of the supernatant; k) adjusting activity of a human factor IX of the supernatant; l) performing aseptic filtration and nano filtration of the supernatant for virus removal; and m) filling and lyophilizing the supernatant to obtain the intravenous injection of PCC.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 100.0
- Lexical Diversity: 1.69565
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15090033', '15278699', '14056363', '13633057', '12842944']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6913557532000288
- 35 USC 102 Novelty (BERT): 0.563511717247232
- Combined Prediction Score: 0.6785713496047492
- Mean Citation Score: 220.655234
- Max Citation Score: 441.10236
- Similarity Product: 389.3230204947424

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test