PATENT CLAIM ANALYSIS

Application Number: 15756947
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["424", "193100"]

Abstract:
Disclosed are methods and compositions for selectively targeting sites of traumatic brain injury (TBI). A brain injury-specific 4-amino acid peptide (sequence CAQK), identified by in vivo phage display screening in mice with acute brain injury, shows selective binding to mouse and human brain injury lesions, and when systemically injected, specifically homes to sites of injury in penetrating and non-penetrating (controlled cortical impact) brain injury models. Also disclosed are methods and compositions for delivering therapeutic compounds to such sites. CAQK-coated nanoparticles containing silencing oligonucleotides provide an alternative to local delivery of therapeutics, which is invasive and can add complications to the injury.

Claim (Index 28):
The method of  claim 25 , wherein the nervous system injury is a central nervous system injury, a peripheral nervous system injury, a brain injury, a spinal cord injury, a neural injury, a neuronal injury, or combinations thereof.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 90.0
- Lexical Diversity: 1.50649
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13594194', '12821050', '11488695', '13481018', '13073275']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.683213655274584
- 35 USC 102 Novelty (BERT): 0.5252652029451276
- Combined Prediction Score: 0.6674188100416384
- Mean Citation Score: 254.283728
- Max Citation Score: 292.1772200000001
- Similarity Product: 190.01366853421337

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test