PATENT CLAIM ANALYSIS

Application Number: 16109288
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-05
Patent Classification: ["435", "006120"]

Abstract:
This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

Claim (Index 2):
A kit for detecting at least one genetic variation in a polynucleotide analyte in a sample, comprising a first primer and a second primer, wherein a fluorophore is attached to the first primer, a quencher is attached to the second primer, the first primer and the second primer are specific for the polynucleotide analyte, at least one of the first primer and the second primer hybridizes to a region of the polynucleotide analyte encoding the at least one genetic variation, the fluorophore is different from the quencher, and the first primer and the second primer is used to detect the least one genetic variation according to the steps of:\n a) measuring a first signal generated by the fluorophore and quencher; b) performing at least one polymerase chain reaction (PCR) reaction with the first primer and the second primer using the polynucleotide analyte as a template, thereby amplifying the template to generate a PCR amplification product comprising the at least one genetic variation; c) measuring a second signal generated by the fluorophore and quencher from the PCR amplification product; d) comparing the first and second signals to determine a change between the first and second signals; and e) determining the presence or absence of the at least one genetic variation based i) on the change in signal as determined in step e); and ii) by comparing said change to the change in signal observed upon PCR amplification for a corresponding polynucleotide analyte lacking the at least one genetic variation in the presence of the first primer and the second primer.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 96.0
- Lexical Diversity: 1.71739
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15675048', '14633094', '14210199', '11988946', '14566596']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.597801188086852
- 35 USC 102 Novelty (BERT): 0.6486474001352539
- Combined Prediction Score: 0.6028858092916922
- Mean Citation Score: 357.072692
- Max Citation Score: 656.3939999999999
- Similarity Product: 594.3398414855003

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test