PATENT CLAIM ANALYSIS

Application Number: 15891170
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["424", "450000"]

Abstract:
Lyophilized liposomal formulations with two or more encapsulated drugs are disclosed. These formulations display superior drug retention profiles and also maintain size distribution following lyophilization and reconstitution.

Claim (Index 1):
A lyophilized gel-phase liposomal composition, which composition comprises:\n (a) gel-phase liposomes that exhibit a melting phase temperature (T c ) of at least 37\u00b0 C. and wherein the liposome membrane of said liposomes comprises no more than 20 mol % cholesterol and at least 1 mol % of a phosphatidylglycerol (PG) or a phosphatidylinositol (PI) or both; and wherein at least two therapeutic and/or diagnostic agents are stably associated with said liposomes; and;\n (b) a cryoprotectant external to said liposomes; and \n wherein said liposomes contain substantially no internal cryoprotectant, and\n wherein when said lyophilized gel-phase liposomal composition is reconstituted in a pharmaceutical carrier, the mean diameter of the liposomes is maintained as compared to said composition prior to lyophilization and said agents are substantially retained in the liposomes.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 88.0
- Lexical Diversity: 1.11538
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14352662', '14216605', '09122427', '10294474', '11018574']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7076399915717078
- 35 USC 102 Novelty (BERT): 0.5584749804319703
- Combined Prediction Score: 0.692723490457734
- Mean Citation Score: 262.631952
- Max Citation Score: 433.29733
- Similarity Product: 350.4952427198231

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test