PATENT CLAIM ANALYSIS

Application Number: 16181261
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-02
Patent Classification: ["435", "325000"]

Abstract:
The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.

Claim (Index 42):
The method of  claim 32 , wherein the induced pluripotent stem cells are maintained in culture.

Metadata:
- Claim Count in Document: 83.0
- Percentile: 98.0
- Lexical Diversity: 1.58571
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14292317', '13893166', '15148230', '12962498', '14322526']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6389811097128958
- 35 USC 102 Novelty (BERT): 0.5948548164802849
- Combined Prediction Score: 0.6345684803896346
- Mean Citation Score: 465.348888
- Max Citation Score: 633.7559
- Similarity Product: 401.658718412745

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test