PATENT CLAIM ANALYSIS

Application Number: 15990860
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "023000"]

Abstract:
The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline, or in the form of amorphous/crystalline solid dispersions/solutions with pharmaceutically acceptable polymers and preparation process thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition.

Claim (Index 4):
A process for preparing compound (7) according to  claim 1 , comprises:\n (a) reacting compound (1) with sodium borohydride in the presence of aluminium chloride and tetrahydrofuran to obtain diphenylmethane compound (2); (b) coupling diphenylmethane compound (2) with the protected gluconolactone (3) in the presence of n-butyllithium and tetrahydrofuran, followed by treatment with methanesulfonic acid in methanol to obtain compound (4); (c.1) treating compound (4) with acetic anhydride in the presence of N,N-dimethylaminopyridine, wherein the hydroxy groups are protected to form compound (5); (or) (c.2) compound (4) obtained from step (b) is subjected to reduction using triethylsilane and boron trifluoride etherate to obtain compound 5a; (d.1) compound (5) from step (c.1) is further reacted with triethylsilane in the presence of borontrifluoride etherate and dichloromethane to form compound (6); (or) (d.2) compound (5a) obtained from step (c.2) is reacted with acetic anhydride to protect the hydroxy groups in the presence of N,N-dimethylaminopyridine to form compound (6); (e) subjecting compound (6) to O-demethylation in the presence of thiourea-AlCl 3  reagent pair and dodecanethiol to form compound (7).

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.85714
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15105620', '15430409', '15571112', '15553843', '15759562']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.793330980446928
- 35 USC 102 Novelty (BERT): 0.5219493374218934
- Combined Prediction Score: 0.7661928161444245
- Mean Citation Score: 273.46067400000004
- Max Citation Score: 305.99005
- Similarity Product: 195.4543047923445

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test