PATENT CLAIM ANALYSIS

Application Number: 16185020
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["424", "450000"]

Abstract:
A liposomal paclitaxel palmitate formulation, including: 0.1-1% (w/v) of a paclitaxel palmitate; 1-10% (w/v) of a lecithin; 0.05-1.0% (w/v) of distearoyl phosphoethanolamine-polyethylene glycol 2000 (DSPE-PEG2000); and water. A method for preparing the formulation includes: mixing the paclitaxel palmitate, lecithin, cholesterol, DSPE-PEG2000, and an organic solvent, and heating the resulting mixture at 25-75° C. to yield an organic phase; heating an aqueous phase to 25-75° C., and stirring and adding the organic phase to the aqueous phase, to yield a crude liposome; emulsifying the crude liposome, to yield a liposome solution; adding a cryoprotector to the liposome solution, adding water to the liposome solution to reach a preset calibration, adding a pH modifier, filtering the liposome solution, and packaging.

Claim (Index 5):
The formulation of  claim 1 , comprising:\n the paclitaxel palmitate: 0.1-0.7% (g/mL); the lecithin: 1-8% (g/mL); cholesterol: 0-0.5% (g/mL); the DSPE-PEG2000: 0.1-0.8% (g/mL); a cryoprotector: 5-40% (g/mL); a pH modifier adapting to regulate a pH value of the formulation to be 4.0-8.0; and water.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 98.0
- Lexical Diversity: 2.4918
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15300688', '14765620', '10703187', '12741364', '14650355']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7259250715706896
- 35 USC 102 Novelty (BERT): 0.5195218704870285
- Combined Prediction Score: 0.7052847514623235
- Mean Citation Score: 260.81592
- Max Citation Score: 296.661
- Similarity Product: 177.01254762160778

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test