PATENT CLAIM ANALYSIS

Application Number: 16108800
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["546", "153000"]

Abstract:
The present application provides deuterium-substituted quinoline derivatives, preparation methods thereof and uses thereof. In particular, the present application provides deuterium-substituted compounds of anlotinib, a tyrosine kinase inhibitor, and their preparation methods.

Claim (Index 17):
A process for the preparation of a compound of  claim 1 , comprising:\n (1) reacting a compound of Formula C and a compound of Formula B in the presence of a base and a solvent to give a compound of Formula D; (2) deprotecting the compound of Formula D to give a compound of Formula E; (3) reacting the compound of Formula E and a compound of Formula F in a solvent in the presence of a base to give a compound of Formula G; (4) converting the compound of Formula G to a compound of Formula H; wherein each of X, and Y is independently C(R 8 ) 3 ; each of Z, U, and V is independently C(R 9 ) 2 ; and each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9  is independently hydrogen or deuterium; PG 1  and PG 2  are protecting groups; and L is a leaving group; provided that at least one of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9  is deuterium.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 96.0
- Lexical Diversity: 1.48
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13513982', '14211889', '15064895', '15809107', '13380693']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7628757747399301
- 35 USC 102 Novelty (BERT): 0.503677143399435
- Combined Prediction Score: 0.7369559116058806
- Mean Citation Score: 195.492192
- Max Citation Score: 198.1763
- Similarity Product: 111.24777558883429

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test