PATENT CLAIM ANALYSIS

Application Number: 16007880
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "221000"]

Abstract:
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Claim (Index 1):
A unit dose of a pharmaceutical composition that is formulated for relief of symptoms of a pulmonary condition in a subject in need thereof;\n wherein the unit dose contains an amount of a compound that constitutes a means for selectively inhibiting Bcl-2 or Bcl-xL in a formulation that is configured for administration in or around a lung of the subject, wherein the formulation of the composition and the amount of the compound in the unit dose configure the unit dose such that one or more administrations of the unit dose in or around the lung of the subject during a treatment period is effective in selectively removing senescent cells from the lung, thereby providing the subject with a subsequent therapeutic period of at least one month during which the composition is not administered, and the symptoms of the pulmonary condition in the lung are relieved as a result of the administration of the composition to the lung during the treatment period.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 94.0
- Lexical Diversity: 1.58333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15955542', '15956613', '15827539', '15647688', '15467129']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8917937516044853
- 35 USC 102 Novelty (BERT): 0.7158956972796058
- Combined Prediction Score: 0.8742039461719974
- Mean Citation Score: 782.6381399999997
- Max Citation Score: 864.57825
- Similarity Product: 742.0156960357277

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test