PATENT CLAIM ANALYSIS

Application Number: 15953989
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["530", "300000"]

Abstract:
Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance, Applicants are able to derive peptides that are not only stable to a broad spectrum of proteases, but also stable to other drug processing enzymes such as cytochrome P450s. This approach provides a general method to the rapid development of highly stable peptides for therapeutic development and diagnosis. The peptides are further modified for oral bioavailability. The methods can be applied to similar peptides for the making of therapeutic compositions

Claim (Index 8):
A method for generating one or stable, bioavailable peptide(s), comprising:\n a. mutating a library of nucleic acids encoding peptides selected for a pre-determined specificity to incorporate one or more amino acids that impart stability; b. incorporating one or more stop codons; c. supplementing the library with one or more tRNA charged with an amino acid that imparts stability to suppress the stop codon; d. translating one or more of the individual sequences of the nucleic library to one or more peptides; e. cyclizing the one or more peptides; and f. selecting individual peptides for protease resistance wherein the amino acid that imparts stability is selected from the group of: an 2-aminoisobutyric acid (AIB), a D-amino acid, a beta (B) amino acid, and an N-methyl amino acid.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 91.0
- Lexical Diversity: 1.51515
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14342347', '14492713', '14060932', '11666940', '13990180']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6526834426640258
- 35 USC 102 Novelty (BERT): 0.5615992495500401
- Combined Prediction Score: 0.6435750233526272
- Mean Citation Score: 268.653796
- Max Citation Score: 455.38745
- Similarity Product: 364.2731863828957

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test