PATENT CLAIM ANALYSIS

Application Number: 15764215
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["514", "235800"]

Abstract:
The present invention provides the use of protein kinase inhibitors, in particular JAK2 inhibitors of formula (I), as set forth in the specification, in the treatment of solid organ transplant rejection and graft versus host disease (GvHD). Also provided are combination therapies for the treatment of solid organ transplant rejection and graft versus host disease.

Claim (Index 1):
A method of treating transplant rejection in a mammal that has received a solid organ or cell transplant comprising administration to a mammal in need thereof of a therapeutically effective amount of a compound of formula I: wherein: R 1  and R 2  are H; Z 2  is-N(H)\u2014; Ar 1  is selected from the group consisting of: wherein R 10  is methoxy or fluorine; (i) k is an integer selected from 0 or 1; Ar 2  is a group of the formula wherein R 11  is H or selected from the group consisting of: L is a group of formula:\n \u2014X 1 \u2014Y\u2014X 2 \u2014 \n wherein X 1  is attached to Ar 1  and X 2  is attached to Ar 2 , and wherein X 1 , X 2  and Y are selected such that the group L has between 5 and 15 atoms in the normal chain, wherein X 1  is selected from the group consisting of: (a) \u2014OCH 2 \u2014 (b) \u2014OCH 2 CH 2 \u2014, and (c) \u2014CH 2 OCH 2 \u2014; wherein X 2  is selected from the group consisting of: (a) \u2014CH 2 O\u2014, (b) \u2014CH 2 CH 2 O\u2014, and (c) \u2014CH 2 OCH 2 \u2014; Y is a group of formula \u2014CR a \u2550CR b \u2014, wherein R a  and R b  are H, or a pharmaceutically acceptable salt or N-oxide thereof.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 90.0
- Lexical Diversity: 1.6
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14523650', '15586058', '11208046', '13640162', '10732429']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7472415279151418
- 35 USC 102 Novelty (BERT): 0.5050901019247865
- Combined Prediction Score: 0.7230263853161063
- Mean Citation Score: 249.400688
- Max Citation Score: 274.87634
- Similarity Product: 205.7704965007329

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test