PATENT CLAIM ANALYSIS

Application Number: 15780134
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "341000"]

Abstract:
The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

Claim (Index 1):
A compound of the formula: wherein R 1  is aryl or heteroaryl, wherein said aryl and heteroaryl groups are optionally substituted with one to three substituents independently selected from the group consisting of halo, nitro, cyano, oxo, R 4 , OR 4 , C(O)R 4 , C(O)OR 4 , NR 4 R 5 , C 1-3  alkyl-NR 4 R 5 , NHC(O)R 4 , NHC(O)OR 4 , C 3-6  cycloalkyl and heteroaryl (which is optionally substituted with halo, cyano, C(O)NR 4 R 5  or R 4 ); R 2  is hydrogen or CH(R 2a )(R 2b ); R 2a  is C 1-6  alkyl, aryl, heteroaryl, C 3-6  cycloalkyl or heterocyclyl, wherein said alkyl group is optionally substituted with one to three substituents independently selected from the group consisting of halo, cyano and OR 4 , and wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three substituents independently selected from the group consisting of halo, nitro, cyano, oxo, R 4  and OR 4 ; R 2b  is hydrogen or C 1-6  alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy and cyano; R 3  is aryl, heteroaryl, C 3-10  cycloalkyl or heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three substituents independently selected from the group consisting of halo, nitro, cyano, oxo, R 4 , OR 4 , C(O)R 4 , C(O)OR 4 , C(O)NR 4 R 5 , NR 4 R 5 , NHC(O)R 4 , NHC(O)OR 4 , NHC(O)C 1-4 alkyl-OR 4  and heteroaryl; R 4  is hydrogen or C 1-6  alkyl, which is optionally substituted with one to three groups independently selected from the group consisting of halo and hydroxy; R 5  is hydrogen or C 1-6  alkyl, which is optionally substituted with one to three groups independently selected from the group consisting of halo and hydroxy; R 6  is hydrogen, cyano, halo, R 4  or OR 4 ; R 7  is hydrogen, cyano, halo, R 4  or OR 4 ; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.44737
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15771538', '15116576', '15329609', '15312839', '15329634']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8314101961504393
- 35 USC 102 Novelty (BERT): 0.5756777529516987
- Combined Prediction Score: 0.8058369518305653
- Mean Citation Score: 442.1717540000001
- Max Citation Score: 450.88834
- Similarity Product: 436.2030122539544

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test