PATENT CLAIM ANALYSIS

Application Number: 15984324
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["702", "019000"]

Abstract:
Methods for screening clonotypes are provided. Data representing a plurality of cells from a single subject is obtained. The data represents a plurality of clonotypes. The data includes a plurality of contigs for each respective clonotype in the plurality of clonotypes. Each respective contig in the plurality of contigs comprises (i) an indication of chain type for the respective contig and (ii) a contig sequence of an mRNA of the respective cell. There is determined, using the data, for each respective clonotype in the plurality of clonotypes, a number of the plurality of cells that represent the respective clonotype. In some instances, more than one cell in the plurality of cells have the same clonotype in the plurality of clonotypes. In some instances, the plurality of clonotypes comprises 25 clonotypes and where the plurality of cells includes at least one cell for each clonotype in the plurality of clonotypes.

Claim (Index 15):
A computer system comprising a memory, a processor and a display, the memory comprising one or more programs that use the processor to perform a method of screening a plurality of clonotypes, the method comprising:\n obtaining a clonotype dataset representing a plurality of cells from a biological sample of a single subject through a backend server process, wherein,\n the clonotype dataset comprises the plurality of clonotypes, \n the clonotype dataset includes a corresponding one or more contigs for each respective clonotype in the plurality of clonotypes, \n each respective contig in the clonotype dataset comprises an indication of chain type for the respective contig and a contig sequence, \n each respective contig sequence in the clonotype dataset is supported by a plurality of sequence reads obtained from mRNA encoding all or portions of a cell receptor chain from the individual cell in the plurality of cells corresponding to the respective contig sequence, and \n each contig sequence for a respective single cell in the plurality of cells has the same barcode, from a plurality of barcodes, that uniquely identifies the respective single cell; \n obtaining a discrete attribute value dataset that also represents the plurality of cells in the biological sample, wherein the discrete attribute value dataset comprises a plurality of clusters, each cluster including a subset of cells of the plurality of cells, and each respective cell identified by a barcode in the plurality of barcodes that supports the cell, wherein each cluster in the plurality of clusters represent a subset of cells of the plurality of cells that are clustered together based on an expression pattern of the mRNA within the subset of cells; obtaining a selection of a first cluster in the plurality of clusters through a front-end web application that runs as a separate process than the backend server process; and determining, using the plurality of barcodes, for each respective clonotype in the plurality of clonotypes, a number of the plurality of cells in the clonotype dataset that represent the respective clonotype that are in the first cluster of the discrete attribute value dataset.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 2.67742
- Patent Class: 702.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15891607', '13834794', '13196885', '13861941', '14317087']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.1233776017338718
- 35 USC 102 Novelty (BERT): 0.5503284315166738
- Combined Prediction Score: 0.166072684712152
- Mean Citation Score: 322.438622
- Max Citation Score: 443.41837
- Similarity Product: 300.0987923705983

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test