PATENT CLAIM ANALYSIS

Application Number: 16357340
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-09
Patent Classification: ["530", "311000"]

Abstract:
Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

Claim (Index 1):
A somatostatin receptor ligand comprising a peptide moiety selected from the group consisting of: PTR-Y D-Phe\u2003Cys\u2003Tyr\u2003D-Trp\u2003Lys\u2003Thr\u2003Phe\u2003GlyS2   PTR-58 (SEQ\u2003ID\u2003NO:\u200316) D-Phe\u2003Arg\u2003Cys\u2003Phe\u2003D-Trp\u2003Lys\u2003Thr\u2003Phe\u2003GlyS2   PTR-Orn (SEQ\u2003ID\u2003NO:\u200320) D-Phe\u2003Cys\u2003Phe\u2003Trp\u2003D-Trp\u2003Orn\u2003Thr\u2003Phe\u2003GlyS2   PTR- (SEQ\u2003ID\u2003NO:\u200329) D-Phe\u2003Arg\u2003Cys\u2003Phe\u2003D-Trp\u2003Orn\u2003Thr\u2003Phe\u2003GlyS2   PTR-Y58 (SEQ\u2003ID\u2003NO:\u200334) D-Phe\u2003Arg\u2003Cys\u2003Tyr\u2003D-Trp\u2003Lys\u2003Thr\u2003Phe\u2003GlyS2   PTR-OrnY (SEQ\u2003ID\u2003NO:\u200338) D-Phe\u2003Cys\u2003Tyr\u2003D-Trp\u2003Orn\u2003Thr\u2003Phe\u2003GlyS2   PTR-56 (SEQ\u2003ID\u2003NO:\u200346) D-Phe\u2003Cys\u2003Arg\u2003Phe\u2003D-Trp\u2003Lys\u2003Thr\u2003Phe\u2003GlyS2   PTR-21 (SEQ\u2003ID\u2003NO:\u200348) Cys\u2003Arg\u2003Phe\u2003D-Trp\u2003Lys\u2003Thr\u2003Phe\u2003GlyS2   PTR-FFR (SEQ\u2003ID\u2003NO:\u200344) D-Phe\u2003Cys\u2003Arg\u2003Phe\u2003Phe\u2003D-Trp\u2003Lys\u2003Thr\u2003Phe\u2003GlyS2   PTR-HCys (SEQ\u2003ID\u2003NO:\u200351) D-Phe\u2003H-Cys\u2003Phe\u2003Trp\u2003D-Trp\u2003Lys\u2003Thr\u2003Phe\u2003GlyS2   PTR-DCys (SEQ\u2003ID\u2003NO:\u200353) D-Phe\u2003D-Cys\u2003Phe\u2003Trp\u2003D-Trp\u2003Lys\u2003Thr\u2003Phe\u2003GlyS2   PTR-Arg (SEQ\u2003ID\u2003NO:\u200363) D-Phe\u2003Cys\u2003Phe\u2003Trp\u2003D-Trp\u2003Arg\u2003Thr\u2003Phe\u2003GlyS2   PTR-52 (SEQ\u2003ID\u2003NO:\u200361) D-Phe\u2003Cys\u2003Phe\u2003Trp\u2003D-Trp\u2003LysAc\u2003Thr\u2003Phe\u2003GlyS2   PTR-HK (SEQ\u2003ID\u2003NO:\u200367) D-Phe\u2003Cys\u2003Phe\u2003Trp\u2003D-Trp\u2003HomoLys\u2003Thr\u2003Phe\u2003GlyS2 and   PTR-Aib (SEQ\u2003ID\u2003NO\u200357)\u2003 D-Phe\u2003Cys\u2003Phe\u2003Trp\u2003D-Trp\u2003Aib\u2003Thr\u2003Phe\u2003GlyS2; and an active agent moiety either directly bound to the amino acid residue at the N-terminus of the peptide moiety or bound to a linker that is bound to the N-terminus of the peptide moiety; wherein the peptide moiety is cyclized via a disulfide bond between a GlyS2 moiety and the cysteine moiety; wherein the active agent moiety is selected from the group consisting of: an imaging moiety, a therapeutic moiety, a dye, a fluorescent agent, a toxin, a chelator, a metal atom-comprising moiety, a radioactive atom-comprising moiety, a nanoparticle, an ethylene glycol polymer, a photosensitizer, a liposome constituent, and a micelle constituent. or an amide form thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 99.0
- Lexical Diversity: 2.64865
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15509842', '10950378', '11041676', '15263028', '10554240']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7369316574521397
- 35 USC 102 Novelty (BERT): 0.656728725317816
- Combined Prediction Score: 0.7289113642387073
- Mean Citation Score: 466.76161600000006
- Max Citation Score: 754.19617
- Similarity Product: 599.5387215088678

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test