PATENT CLAIM ANALYSIS

Application Number: 16237333
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "210200"]

Abstract:
Substituted 1,2,3-triazoles as NR2B receptor ligands. Such compounds may be used in NR2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by NR2B receptor activity.

Claim (Index 1):
A compound, and pharmaceutically acceptable salts thereof, having the structure of Formula (I): wherein: Ar 1  is selected from the group consisting of:\n (a) phenyl substituted with one substituent selected from the group consisting of: F, Br, I, C 1-6 alkyl, C 1-6 perhaloalkyl, and OC 1-6 perhaloalkyl; phenyl substituted with two or three substituents each independently selected from the group consisting of: halo, C 1-6 alkyl, C 1-6 perhaloalkyl, OC 1-6 alkyl, OC 1-6 perhaloalkyl, C 3-6 cycloalkyl, and azetidinyl; \n (b) pyridinyl; pyridinyl substituted with one or two members each independently selected from the group consisting of halo, CH 3 , CF 3 , and CF 2 H; and \n (c) thienyl substituted with CF 3 ; 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl; or 2,3-dihydro-1H-inden-5-yl; \n R 1  is H, halo, or CH 3 ; R 2  is H or CH 3 ; and Ar 3  is selected from the group consisting of:\n (a) pyridinyl; pyridinyl substituted with one or two substituents each independently selected from the group consisting of: Cl, F, CH 3 , OCH 3 , CF 3 , C(CH 3 ) 2 OH; azetidin-1-yl; 3-fluoroazetidin-1-yl; and 3,3-difluoroazetidin-1-yl; \n (b) pyridazinyl; pyridazinyl substituted with one or two substituents each independently selected from the group consisting of: CH 3 , OCH 3 , and CF 3 ; \n (c) pyrimidin-4-yl; pyrimidin-4-yl substituted with one or two substituents each independently selected from the group consisting of Cl, CH 3 , CF 3 , and OCH 3 ; pyrimidin-2-yl; pyrimidin-2-yl substituted one or two members each independently selected from the group consisting of: halo, C 1-6 alkyl, C 1-6 alkyl substituted with OH or OCH 3 , C(OH)(CH 3 )(CF 3 ), CH 2 OCHF 2 , CH 2 OCF 3 , CH 2 OCH 2 CH 3 , CH(NH 2 )CH 3 , CH 2 NH(CH 3 ), C 1-6 perhaloalkyl, OC 1-6 alkyl, OC 1-6 perhaloalkyl, C(\u2550N\u2014OH)(CH 3 ), NH 2 , NH(CH 3 ), N(CH 3 ) 2 ; NH(CH 2 CH 3 ), NH(CH 2 CHF 2 ), NH(cyclopropyl), NH(difluorocyclobutyl), NH-oxetanyl, CN, C(\u2550O)CH 3 , C(\u2550O)NH(CH 3 ), C(\u2550O)N(CH 3 ) 2 , SO 2 CH 3 , CO 2 CH 3 , C(CH 3 )(\u2550N\u2014OH), cyclopropyl, azetidin-1-yl, 3-fluoroazetidin-1-yl, 3,3-difluoroazetidin-1-yl, 3-(difluoromethyl)azetidin-1-yl, 3-methoxyazetidin-1-yl, 3-fluoro-3-methyl-azetidin-1-yl, pyrrolidin-1-yl, 3-fluoropyrrolidin-1-yl, 3,3-difluoropyrrolidin-1-yl, piperidin-1-yl, morpholinyl, 1H-pyrrol-2-yl, 2-furyl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-pyrazol-1-yl, 2-methyl-1H-imidazol-1-yl, 1-methylpyrazol-3-yl, and phenyl; \n (d) 5-fluoro-pyrazin-2-yl; 5-methylpyrazin-2-yl; 6-methylpyrazin-2-yl; pyrazin-4-yl; (2-thienyl)pyrazin-2-yl, and 2,3-dimethylpyrazin-5-yl; and \n (e) 5-methyl-1H-imidazol-2-yl; 5-methylthiazol-2-yl.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 98.0
- Lexical Diversity: 1.3
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15428710', '16046332', '13503231', '14138941', '15725500']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8102340099865633
- 35 USC 102 Novelty (BERT): 0.6180564318158355
- Combined Prediction Score: 0.7910162521694905
- Mean Citation Score: 440.896106
- Max Citation Score: 546.1803
- Similarity Product: 519.2593978013456

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test