PATENT CLAIM ANALYSIS

Application Number: 16022275
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["424", "143100"]

Abstract:
The present invention provides binding molecules that specifically bind to GITR, e.g., human GITR (hGITR), on T cells and dendritic cells. Binding molecules of the invention are characterized by binding to hGITR with high affinity, in the presence of a stimulating agent, e.g., CD3, are agonistic, and abrogate the suppression of Teff cells by Treg cells. Various aspects of the invention relate to binding molecules, and pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such binding molecules. Methods of using a binding molecule of the invention to detect human GITR or to modulate human GITR activity, either in vitro or in vivo, are also encompassed by the invention.

Claim (Index 68):
A method for inducing or enhancing an immune response to an antigen in a subject, the method comprising:\n administering to the subject an agonistic GITR (glucocorticoid-induced TNFR family-related receptor)-binding antibody, or an antigen-binding fragment thereof, and an antigen, such that an immune response or an enhanced immune response occurs, wherein the antibody or antigen-binding fragment thereof comprises the light chain complementarity determining region (CDR) amino acid sequences shown in amino acid residues 44-54 of SEQ ID NO:2, amino acid residues 70-76 of SEQ ID NO:2, and amino acid residues 109-117 of SEQ ID NO:2, and heavy chain CDR amino acid sequences shown in amino acid residues 45-56 of SEQ ID NO:1, amino acid residues 119-127 of SEQ ID NO:1, and one of amino acid residues 71-86 of SEQ ID NO:1 and amino acid residues 71-86 of SEQ ID NO:66; and administering to the subject an additional antibody or antigen-binding fragment thereof or giving the subject a treatment selected from the group consisting of chemotherapy and hormonal therapy.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 94.0
- Lexical Diversity: 1.875
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15345182', '14665533', '12753402', '11389880', '13782656']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8055904772741539
- 35 USC 102 Novelty (BERT): 0.6787135331536421
- Combined Prediction Score: 0.7929027828621027
- Mean Citation Score: 665.3161759999998
- Max Citation Score: 682.2406
- Similarity Product: 671.1575963259935

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test