PATENT CLAIM ANALYSIS

Application Number: 15970605
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "093200"]

Abstract:
The present invention relates to compositions and methods of generating modified hematopoietic stem or progenitor cells. One aspect of the invention includes a modified hematopoietic stem or progenitor cell comprising a nucleic acid capable of decreasing expression of an endogenous gene or a portion thereof, wherein the endogenous gene encodes a polypeptide comprising an antigen domain targeted by a chimeric antigen receptor (CAR). Another aspect of the invention includes a method for generating a modified hematopoietic stem or progenitor cell. Also included are methods and pharmaceutical compositions comprising the modified cell for adoptive therapy and treating a condition, such as an autoimmune disease or cancer.

Claim (Index 62):
The method of  claim 61 , wherein the HDR template comprises a single-stranded oligonucleotide donor (ssODN) sequence.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 93.0
- Lexical Diversity: 1.79365
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15655432', '14420318', '13817726', '10261078', '14469308']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7149839572652417
- 35 USC 102 Novelty (BERT): 0.5404612672507295
- Combined Prediction Score: 0.6975316882637904
- Mean Citation Score: 337.81790600000005
- Max Citation Score: 363.6766
- Similarity Product: 212.18995897333625

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test