PATENT CLAIM ANALYSIS

Application Number: 16114076
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["514", "415000"]

Abstract:
Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.

Claim (Index 1):
A method for inducing aptosis in a cell comprising a myeloblast produced in acute myeloid leukemia or a lymphocyte produced in diffuse large B cell lymphoma, comprising contacting the cell with an effective amount of a combination of:\n at least one therapeutic agent selected from the group consisting of a bromodomain, an extra-terminal protein inhibitor, an anti-CD20 monoclonal antibody, and a BCL2 inhibitor; and a compound having a structure of Formula (I): or a stereoisomer, a pharmaceutically acceptable salt, or solvate thereof, wherein R 1 , R 2 , R 3 , and R 4  are independently selected from the group consisting of H, Cl, \u2014CN and \u2014CF 3 ; wherein A is selected from the group consisting of H and C 1-6  alkyl; wherein D is selected from the group consisting of \u2014OH and \u2014O(C 1-6  alkyl); wherein R 5  and R 6  are independently selected from the group consisting of H, F, and C 1-6  alkyl, or wherein R 5  and R 6  taken together form a substituted or unsubstituted cycloalkyl ring; wherein R 12  is independently selected from the group consisting of substituted or unsubstituted C 3-8  cycloalkyl, substituted or unsubstituted C 3-8  heterocycloalkyl, wherein R 7 , R 8 , R 9 , R 10  and R 11  are independently selected from the group consisting of H, halogen, CN, CF 3 , C 1-6  alkyl, aryl, heteroaryl, \u2014O(C 1-6  alkyl), \u2014O(aryl), \u2014O(heteroaryl), \u2014CO 2 H, \u2014CO 2 (C 1-6  alkyl), \u2014NHSO 2 (C 1-6  alkyl), \u2014NHSO 2 (aryl), \u2014NHCONH(C 1-6  alkyl), \u2014NHCON(C 1-6  alkyl) 2 , \u2014N(C 1-6  alkyl)CONH 2 , \u2014N(C 1-6  alkyl)CONH(C 1-6  alkyl), \u2014N(C 1-6  alkyl)CON(C 1-6  alkyl) 2 , \u2014SO 2 (C 1-6  alkyl), \u2014SO 2 NH 2 , \u2014SO 2 NH(C 1-6  alkyl), \u2014SO 2 N(C 1-6  alkyl) 2 ; and wherein R 13  selected from the group consisting of \u2014O(C 1-6  alkyl) and \u2014N(C 1-6  alkyl) 2 .

Metadata:
- Claim Count in Document: 44.0
- Percentile: 96.0
- Lexical Diversity: 1.09091
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15660566', '15680905', '15461327', '15357876', '14877708']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7332999276053244
- 35 USC 102 Novelty (BERT): 0.5995033471269636
- Combined Prediction Score: 0.7199202695574883
- Mean Citation Score: 397.409042
- Max Citation Score: 540.7462
- Similarity Product: 436.8382417840123

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test