PATENT CLAIM ANALYSIS

Application Number: 16137421
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["435", "069700"]

Abstract:
The invention provides a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a Family B G-protein coupled receptor (GPCR) that comprises transmembrane helix (TM)-1, TM2 and TM3 of the GPCR; b) a stable protein domain; and c) a second portion of the GPCR comprising TM4, TM5, TM6 and TM7 of the GPCR. The invention also provides a method of crystallising a GPCR comprising providing the fusion protein of the invention and crystallising it to obtain crystals.

Claim (Index 21):
A fusion protein according to  claim 1 , wherein the stable protein domain comprises a soluble, well-folded polypeptide that provides N- and C-termini, the distance between which approximates the distance between helices 3 and 4 in the Family B GPCR, and that provides a hydrophilic surface for crystal lattice contacts, thereby facilitating crystallisation.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 97.0
- Lexical Diversity: 1.86538
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14237678', '14133279', '13420329', '14684217', '13436709']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6942019612667192
- 35 USC 102 Novelty (BERT): 0.6255419817978641
- Combined Prediction Score: 0.6873359633198337
- Mean Citation Score: 417.032598
- Max Citation Score: 621.24963
- Similarity Product: 433.860758533051

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test