PATENT CLAIM ANALYSIS

Application Number: 16075924
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["514", "252180"]

Abstract:
The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as  T. gondii, T. cruzi, P. falciparum, T. brucei , or  L. major  infections, using the novel inhibitors of the invention.

Claim (Index 6):
The compound of  claim 5 , wherein the compound has the structure of formula (Ia): wherein: R 1  is H, C 1-6  alkyl, C 3-6  cycloalkyl, or halogen; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9  are independently selected from H, C 1-6  alkyl, C 3-6  cycloalkyl, or fluorine, provided that at least four of R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9  are H; and R 10  is substituted or unsubstituted C 6-10  aryl or 5- to 10-membered heteroaryl; provided that:\n a. at least one of R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9  is C 1-6  alkyl, C 3-6  cycloalkyl, or halogen; \n b. R 1  is C 4-6  alkyl, C 3-6  cycloalkyl, or fluoro; \n c. R 10  is substituted or unsubstituted 5- to 10-membered heteroaryl or C 10  aryl; \n d. R 10  is phenyl substituted at the meta or ortho position with at least one substituent selected from chloro, alkoxy, phosphoryl, phosphate, phosphonate, phosphinate, amino, amidine, imine, cyano, azido, sulfhydryl, or alkylthio, heterocyclyl, aralkyl, aryl, or heteroaryl; \n e. R 10  is phenyl substituted with C 1-6  alkyl optionally substituted with C 1-6  alkyl, C 3-6  cycloalkyl, halogen, carbonyl, cyano, or hydroxyl; or \n f. R 10  is phenyl substituted with R 12  or X\u2014R 12 .

Metadata:
- Claim Count in Document: 60.0
- Percentile: 96.0
- Lexical Diversity: 1.57576
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12691607', '15038038', '14511847', '13991321', '13256071']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7857867229609655
- 35 USC 102 Novelty (BERT): 0.4973140629764323
- Combined Prediction Score: 0.7569394569625123
- Mean Citation Score: 257.437782
- Max Citation Score: 260.07645
- Similarity Product: 210.1284939047277

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test