PATENT CLAIM ANALYSIS

Application Number: 15753552
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA. The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.

Claim (Index 45):
A method according to  claim 4 , wherein one or more of E, E\u2032 or E\u2033 has a carbamate group, and a cleavable disulfide moiety is within a cyclic structure, according to Formula (X), Formula (Xa), Formula (Xb) or Formula (Xc); wherein a disulfide can be either in its oxidized or reduced (open-ring) form: wherein a, b, k each stands independently for an integer, selected from the group consisting of 0, 1, 2, 3, 4, 5, 6; h is an integer of 1, 2, 3, or 4; Z is selected from the group consisting of hydrogen, fluorine, hydroxyl and amine groups; R and R\u2032 are each independently selected from the group consisting of hydrogen, halogen, hydroxyl group, a methoxy group, and a fluorocarbon group; L 3  has the same meaning as in Formula (I); G is selected from the group consisting of hydrogen, halogen, hydroxyl group, a methoxy group, and a fluorocarbon group; W is selected from oxygen, amide, ester and amine (secondary or tertiary amine); D is a drug as defined in Formula (I).

Metadata:
- Claim Count in Document: 6.0
- Percentile: 88.0
- Lexical Diversity: 1.66102
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15222559', '14872179', '14830799', '15691821', '14690499']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8464260714861881
- 35 USC 102 Novelty (BERT): 0.5948132279170957
- Combined Prediction Score: 0.8212647871292789
- Mean Citation Score: 441.934864
- Max Citation Score: 574.69934
- Similarity Product: 435.14055576160433

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test