PATENT CLAIM ANALYSIS

Application Number: 16222089
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["250", "282000"]

Abstract:
A method of assessing the linearity and dynamic range of a mass spectrometer is described comprising analyzing two or more test standards containing positional isomers, for example, using a series of N isomeric analytes with or without an internal standard where N is an integer from 2 to 6 inclusive. The concentrations of the N isomeric analytes may or may not be interleaved between two or more standards. The method allows for repeated instrument characterization without having many of the problems associated with using only a single standard such as octafluoronaphthalene (OFN), for example, persistence, and it may lessen sample carryover issues between adjacent samples. Methods are described using positional isomers of dibromodifluorobenzene in various configurations that show an improved means for qualitative and quantitative analysis of one or more analytes by GC-MS.

Claim (Index 16):
A kit for determining mass spectrometer linearity, comprising:\n (a) providing N isomeric analytes, wherein N is an integer from 2 to 6 inclusive; (b) running the N isomeric analytes in two analysis runs;\n wherein a first analysis run is performed using a first series of concentrations of the N isomeric analytes and a second analysis run is performed using a second series of concentrations of the N isomeric analytes interleaved in concentration with the first series of concentrations of the N isomeric analytes; and, \n (c) determining an instrument linearity indicator value from a plot of mass spectrometry response versus concentrations of the N isomeric analytes, wherein the instrument linearity indicator value denotes a critical operating linearity characteristic of a mass spectrometer.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 98.0
- Lexical Diversity: 1.56522
- Patent Class: 250.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10508068', '14367230', '15762019', '14579206', '15024104']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6569005315925007
- 35 USC 102 Novelty (BERT): 0.4958109880895069
- Combined Prediction Score: 0.6407915772422014
- Mean Citation Score: 188.175084
- Max Citation Score: 208.79782
- Similarity Product: 143.42391115257143

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test