PATENT CLAIM ANALYSIS

Application Number: 16069814
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "490000"]

Abstract:
Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I, wherein X is C═O or CH 2 ; Y is NH, O or absent; R is a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compounds provided slowly release 2-tert-butyl-4-methoxyphenol in vivo and maintain stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T½=12˜24 h). The compounds provided by the present invention protect the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoid environmental oxidation and increase the environmental stability of drugs containing the compounds.

Claim (Index 5):
A method of preparing a compound of formula I, wherein: X is C\u2550O, Y is NH, and R is selected from any one of the following groups: a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms, and a substituted or unsubstituted aryl group or heteroaryl group, and wherein the substituent groups in R are halogen, amino group, nitro group, ester group, carbonyl group, amino acid derivatives, natural flavone, natural alkaloid, polyethyleneglycol, polyglutamic acid or polysaccharide;\n the method comprising reacting RNH 2  with triphosgene to obtain R\u2014N\u2550C\u2550O; and \n condensing a reaction mixture comprising N\u2550C\u2550O and 2-tert-butyl-4-methoxyphenol.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 95.0
- Lexical Diversity: 1.92593
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11270780', '11737938', '11302307', '12126437', '13511292']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7651642287022304
- 35 USC 102 Novelty (BERT): 0.500968826485891
- Combined Prediction Score: 0.7387446884805966
- Mean Citation Score: 261.405114
- Max Citation Score: 277.76654
- Similarity Product: 225.53024860607863

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test