PATENT CLAIM ANALYSIS

Application Number: 15765377
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "217090"]

Abstract:
The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

Claim (Index 2):
The compound of Formula (I) according to  claim 1 , wherein:\n R 1  is \u2014CF 3  or \u2014C 3-7 cycloalkyl, wherein the \u2014C 3-7 cycloalkyl, is unsubstituted or substituted by one or two substituents selected from \u2014C 1-3 alkyl and halo, or wherein the \u2014C 3-7 cycloalkyl is substituted by one substituent selected from triazolyl, pyridyl, pyridazinyl, imidazolyl, pyrazolyl and isoxazolyl, and wherein the triazolyl, pyridyl, pyridazinyl, imidazolyl, pyrazolyl and isoxazolyl is unsubstituted or substituted by one or two substituents selected from \u2014C 1-3 alkyl and halo; R 2  is hydrogen; G is CH; A is R 3  is \u2014(CH 2 ) n \u2014C(O)N(R 5 )(R 6 ), or or\n R 3  is \u2014O\u2014C 1-3 alkyl, \u2014C 4-7 heterocycloalkyl, \u2014O\u2014C 4-7 heterocycloalkyl, \u2014C 3-7 cycloalkyl, or \u2014O\u2014C 3-7 cycloalkyl, wherein each of \u2014O\u2014C 1-3 alkyl, \u2014C 4-7 heterocycloalkyl, \u2014O\u2014C 4-7 heterocycloalkyl, \u2014C 3-7 cycloalkyl, or \u2014O\u2014C 3-7 cycloalkyl, is unsubstituted or substituted by one or two substituents selected from \u2014C 1-7 alkyl, \u2014C 3-7 cycloalkyl, \u2014OH, \u2550O, \u2014O\u2014C 1-5 alkyl, \u2014C 4-7 heterocycloalkyl, phenyl, pyridyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, and triazolyl, and wherein the \u2014C 1-7 alkyl, \u2014C 3-7 cycloalkyl, \u2014C 4-7 heterocycloalkyl, phenyl, pyridyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, or triazolyl is unsubstituted or further substituted by one or two substituents independently selected from \u2014C 1-5 alkyl and halo; \n Each R 4  is independently hydrogen, halo, or \u2014C 1-3 alkyl, \n R 5  and R 6  are independently H, \u2014C 1-6 alkyl, \u2014C 3-7 cycloalkyl or \u2014C 4-7 heterocycloalkyl, wherein each of \u2014C 1-6 alkyl, \u2014C 3-7 cycloalkyl or \u2014C 4-7 heterocycloalkyl is unsubstituted or substituted by one or two substituents independently selected from F, \u2014CH\u2014F 2 , \u2014CF 3 , \u2014(CH 2 ) n \u2014O\u2014(CH 2 ) m \u2014CH 3 , and \u2014C 3-7 cycloalkyl; \n or R 5  and R 6  together with the nitrogen atom to which they are attached form a 5-8-membered ring or an 8-10-membered bicyclic ring or a 9-10-membered bridged bicyclic ring, wherein each 5-8-membered ring, 8-11-membered bicyclic ring, or 9-10-membered bridged bicyclic ring optionally includes one or more oxygen ring atoms or another nitrogen ring atom, and wherein each 5-8-membered ring, 8-11-membered bicyclic ring, or 9-10-membered bridged bicyclic ring is unsubstituted or substituted by one or two substituents independently selected from \u2014C 1-5 alkyl, \u2014C 3-7 cycloalkyl, \u2014C 4-7 heterocycloalkyl, F, \u2014CHF 2 , \u2014CF 3 , and \u2014(CH 2 ) n \u2014O\u2014(CH 2 ) m \u2014CH 3 ; \n R 5  and R 6  together with the nitrogen atom to which they are attached form 4-azaspiro[2.5]octane, 7-azaspiro[4.5]decane, 2-oxa-8-azaspiro[5.5]undecane, 6-oxa-9-azaspiro[4.5]decane, 2-oxa-8-azaspiro[5.5]undecane, or 1-azaspiro[4.5]decane; \n R 7  and R 8  are independently H, \u2014C 1-6 alkyl, \u2014C 3-7 cycloalkyl or \u2014C 4-7 heterocycloalkyl wherein each of \u2014C 1-6  alkyl, \u2014C 3-7  cycloalkyl or \u2014C 4-7  heterocycloalkyl is unsubstituted or substituted by one or two substituents independently selected from F, \u2014CHF 2 , \u2014CF 3 , and \u2014(CH 2 ) n \u2014O\u2014(CH 2 ) m \u2014CH 3 , \n or R 7  and R 8  together with the carbon atoms to which they are attached form a 5-8-membered ring, which optionally includes one or more oxygen or nitrogen atoms as ring atoms, and wherein the 5-8-membered ring is unsubstituted or substituted by one or two substituents independently selected from \u2014C 1-5 alkyl, \u2014C 3-7 cycloalkyl, \u2014C 4-7 heterocycloalkyl, F, \u2014CHF 2 , \u2014CF 3 , \u2550O, and \u2014(CH 2 ) n \u2014O\u2014(CH 2 ) m \u2014CH 3 ; \n Each n is independently 0 or 1; \n Each m is independently 0 or 1; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.07407
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15765354', '15735977', '15736075', '15105306', '12899410']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7818750905168943
- 35 USC 102 Novelty (BERT): 0.6008008990856163
- Combined Prediction Score: 0.7637676713737666
- Mean Citation Score: 389.988172
- Max Citation Score: 523.7763
- Similarity Product: 448.6053315602839

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test