PATENT CLAIM ANALYSIS

Application Number: 16381288
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["536", "023100"]

Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

Claim (Index 19):
A double-stranded short interfering nucleic acid (siNA) molecule comprising a sense strand and an antisense strand, wherein:\n a) the antisense strand is complementary to the nucleotide sequence of SEQ ID NO: 449; b) each strand of said double-stranded siNA molecule is 21 nucleotides in length; c) all 21 nucleotides of each strand of the siNA molecule are base-paired to the complementary nucleotides of the other strand of the siNA molecule; (d) the sense strand comprises 10 or more 2\u2032-deoxy, 2\u2032-O-methyl, 2\u2032-deoxy-2\u2032-fluoro, or universal base modified nucleotides; (e) the antisense strand comprises 10 or more 2\u2032-deoxy, 2\u2032-O-methyl, 2\u2032-deoxy-2\u2032-fluoro, or universal base modified nucleotides; and (f) 10 or more pyrimidine nucleotides of the sense and/or antisense strand are 2\u2032-deoxy, 2\u2032-O-methyl or 2\u2032-deoxy-2\u2032-fluoro nucleotides; and wherein the siNA molecule downregulates expression of a Hepatitis B virus target gene.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 100.0
- Lexical Diversity: 1.83099
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15677719', '14514112', '10720448', '13480655', '14861805']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8029664332793681
- 35 USC 102 Novelty (BERT): 0.6762898941103949
- Combined Prediction Score: 0.7902987793624707
- Mean Citation Score: 791.5305999999997
- Max Citation Score: 809.9694
- Similarity Product: 614.1995598057031

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test