PATENT CLAIM ANALYSIS

Application Number: 16069546
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["424", "001890"]

Abstract:
Radiolabeled compounds which are erlotinib analogs that feature a radioactive halogen and processes of preparing same are disclosed. Uses of these radiolabeled compounds in radioimaging, for identifying and monitoring a level, distribution and/or mutational status of deregulated EGFR, and/or in radiotherapy, are also disclosed.

Claim (Index 76):
A process of preparing the radiolabeled compound of  claim 48 , the process comprising reacting a compound represented by Formula IIa or IIb: wherein: A 1  is \u2014CR 1 R 2 B 1 , \u2014CR 1 R 2 Q 1 W 1 , or forms with the oxygen to which it is attached W 1 ; and A 2  is \u2014CR 3 R 4 B 2 , \u2014CR 3 R 4 Q 2 W 2 , or forms with the oxygen to which it attached W 1 ; B 1  and B 2  are each independently as defined for R 1 -R 21 ; Q 1  and Q 2  are each independently as defined for Q or is absent; and W 1  and W 2  are each independently a reactive group, provided that at least one of A 1  and A 2  forms with the oxygen to which it is attached, or comprises, said reactive group, with a compound represented by Formula III(1) and/or III(2):\n L A -(CR 1 R 2 )m(Q)k-Z \u2003\u2003Formula III(1) \n L A -(CR 3 R 4 )m(Q)k-Z \u2003\u2003Formula III(2) \n wherein: L A  is a leaving group; Z is said radioactive halogen; and m is 0 or 1; and k is 0 or 1, whereas: said compound of Formula III(1) is reacted with a compound represented by Formula IIa or IIb in which A 1  forms, or comprises, said W 1 , and a compound represented by Formula III(2) is reacted with a compound represented by Formula IIa or Hb in which A 2  forms a part of, or comprises, said W 2 ; when A 1  forms with the oxygen atom to which it is attached said W 1 , m in Formula III(1) is 1; when A 2  forms with the oxygen atom to which it is attached said W 2 , m in Formula III(2) is 1; when A 1  is \u2014CR 1 R 2 Q 1 W 1 , m and k in Formula III(1) are each 0; and when A 2  is \u2014CR 3 R 4 Q 2 W 2 , m and k in Formula III(2) are each 0.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 95.0
- Lexical Diversity: 1.38889
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11714760', '10659747', '12449129', '14023681', '12631116']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4489643346782167
- 35 USC 102 Novelty (BERT): 0.5153661710259944
- Combined Prediction Score: 0.4556045183129945
- Mean Citation Score: 235.110082
- Max Citation Score: 283.49173
- Similarity Product: 195.6187386840427

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test