PATENT CLAIM ANALYSIS

Application Number: 15947680
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["435", "462000"]

Abstract:
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Claim (Index 156):
A method of cleaving or editing a target DNA molecule or modulating transcription of at least one gene encoded thereon, the method comprising:\n contacting a target DNA molecule having a target sequence with an engineered and/or non-naturally-occurring Type II Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)\u2014CRISPR associated (Cas) (CRISPR-Cas) system comprising:\n a) a single molecule DNA-targeting RNA comprising\n i) a targeter-RNA that hybridizes with the target sequence, and \n ii) an activator-RNA that hybridizes with the targeter-RNA to form a double-stranded RNA duplex of a protein-binding segment, \n \n wherein the targeter-RNA and the activator-RNA are covalently linked to one another with intervening nucleotides; and \n b) a Cas9 protein, \n wherein the single molecule DNA-targeting RNA forms a complex with the Cas9 protein, thereby targeting the Cas9 protein to the target DNA molecule, whereby said target DNA molecule is cleaved or edited or transcription of at least one gene encoded by the target DNA molecule is modulated, and wherein said contacting occurs in a eukaryotic cell.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 91.0
- Lexical Diversity: 2.25424
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13842859', '14942782', '15138604', '15803424', '15925544']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4063211345608971
- 35 USC 102 Novelty (BERT): 0.7230755201675523
- Combined Prediction Score: 0.4379965731215626
- Mean Citation Score: 736.72044
- Max Citation Score: 778.5936
- Similarity Product: 774.0735735872269

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test