PATENT CLAIM ANALYSIS

Application Number: 16106345
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["514", "342000"]

Abstract:
A pharmaceutical combination comprising: (a) an alpha-isoform specific phosphatidylinositol-3-kinase inhibitor (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or any pharmaceutically acceptable salt thereof, (b) an mTOR inhibitor and (c) exemestane or any pharmaceutically acceptable salt thereof, particularly for use in the treatment or prevention of a proliferative disease; uses of such a combination in the preparation of a medicament for the treatment or prevention of a proliferative disease; pharmaceutical compositions of the combination of said therapeutic agents and methods of treating a proliferative disease in a subject comprising administering to said subject a therapeutically effective amount of such a combination.

Claim (Index 9):
A commercial package comprising as active ingredient an alpha-isoform specific phosphatidylinositol-3-kinase (PI3K) inhibitor inhibitor (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or any pharmaceutically acceptable salt thereof, and instructions for simultaneous, separate or sequential administration of said active ingredient with (a) an mTOR inhibitor everolimus or any pharmaceutically acceptable salt thereof and (b) exemestane or any pharmaceutically acceptable salt thereof to a patient in need thereof for use in the treatment of a proliferative disease.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 96.0
- Lexical Diversity: 1.85294
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15646494', '13799076', '14240499', '14429367', '15719636']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7463076156000575
- 35 USC 102 Novelty (BERT): 0.5339973529541385
- Combined Prediction Score: 0.7250765893354657
- Mean Citation Score: 307.719622
- Max Citation Score: 351.56668
- Similarity Product: 281.5877481939244

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test