PATENT CLAIM ANALYSIS

Application Number: 16123009
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-02
Patent Classification: ["514", "249000"]

Abstract:
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (“mGluR2”). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.

Claim (Index 46):
A method of treating a patient suffering from dementia comprising administering to a patient in need thereof therapeutically effective amount of a compound of Formula (I) or a stereoisomeric form thereof, wherein R 1  is phenyl or 2-pyridinyl, each optionally substituted with one or more substituents each independently selected from the group consisting of halo, C 1-4 alkyl, monohaloC 1-4 alkyl, polyhaloC 1-4 alkyl, \u2014O\u2014C 1-4 alkyl, \u2014C 1-4 alkyl-O\u2014C 1-4 alkyl, monohaloC 1-4 alkyloxy, polyhaloC 1-4 alkyloxy, \u2014C 1-4 alkyl-OH, C 1-4 alkylthio, monohaloC 1-4 alkylthio, polyhaloC 1 -4alkylthio, cyano, C 3-7 cycloalkyl optionally substituted with trifluoromethyl, and \u2014SF 5 ; or R 1  is R 2  is R 3  is selected from the group consisting of hydrogen and C 1-4 alkyl; R 4  is selected from the group consisting of hydrogen, C 1-4 alkyl, mono polyhaloC 1-4 alkyl, polyhaloC 1-4 alkyl, \u2014C 1-4 alkyl-O\u2014C 1-4 alkyl, and \u2014C 1-4 alkyl-OH; R 5  and R 6  are each independently selected from the group consisting of hydrogen, halo, cyano, C 1-4 alkyl, \u2014C 1-4 alkyl-OH, C 3-7 cycloalkyl, monohaloC 1-4 alkyl, polyhaloC 1-4 alkyl, \u2014C 1-4 alkyl-O\u2014C 1-4 alkyl, \u2014O\u2014C 1-4 alkyl, monohaloC 1-4 alkyloxy, polyhaloC 1-4 alkyloxy, 1-acetylazetidin-3-yl, and NR\u2032R\u2033; and R\u2032 and R\u2033 are each independently selected from the group consisting of hydrogen and \u2014C 1-4 alkyl; or R\u2032 and R\u2033 together with the nitrogen atom to which they are attached, form a heterocyclic group selected from the group consisting of 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, 1-piperazinyl, and 4-morpholinyl; wherein 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, 1-piperazinyl, and 4-morpholinyl are optionally substituted with a substituent selected from the group consisting of halo, hydroxy, \u2014C 1-4 alkyl, monohaloC 1-4 alkyl, polyhaloC 1-4 alkyl, and \u2014(CO)C 1-4 alkyl; or a N-oxide or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 97.0
- Lexical Diversity: 1.55556
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14896230', '15976223', '15500319', '15976037', '15500600']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4600022546439511
- 35 USC 102 Novelty (BERT): 0.6610409785900269
- Combined Prediction Score: 0.4801061270385587
- Mean Citation Score: 451.528374
- Max Citation Score: 656.3193
- Similarity Product: 593.2257520659327

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test