PATENT CLAIM ANALYSIS

Application Number: 15743424
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["546", "276700"]

Abstract:
The invention provides compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D 1 , D 2 , D 3 , X, Y, A 1 , A 2 , R 1 , R 5  and the subscript a are as described herein. The compounds are CETP inhibitors and are useful for raising FIDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:

Claim (Index 4):
The compound of  claim 3 , or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is CH 3 , CF 3 , \u2014OCH 3 , \u2014OCF 3 , F, C 1 , or \u2014NR 6 R 7 ; R 6  and R 7  are each independently H or \u2014C 1 -C 3  alkyl; D 1  is N or CR 2 , wherein R 2  is H, \u2014C 1 -C 3 alkyl, F, or C 1 ; D 2  is N or CR 3 , wherein R 3  is H, \u2014C 1 -C 3 alkyl, F, or C 1 ; D 3  is N or CR 4 , wherein R 4  is H, \u2014C 1 -C 3 alkyl, F, or C 1 ; at least one of D 1 , D 2 , or D 3  is CR 2 , CR 3 , or CR 4 ; R 5  is CH 3 ; A 1  is phenyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, oxazolyl, pyrrolyl, thienyl, furyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclohexenyl, cyclopentyl, or cyclopentenyl, wherein A 1  is optionally substituted with 1-3 groups which are each independently F, C 1 , \u2014OCH 3 , \u2014OCF 3 , \u2014C 1 -C 3 alkyl, \u2014CN, or CF 3 , and optionally one substituent group Z; Z is A 3 , \u2014CH 2 CH 2 CO 2 R 8 , \u2014CH 2 CH 2 C(O)NR 6 R 7 , \u2014CH 2 CH 2 SO 2 NR 6 R 7 , or \u2014CH 2 CH 2 -HET(2), wherein HET(2) is optionally substituted with 1-2 substituent groups which are each independently CH 3 , CF 3 , \u2014OCH 3 , \u2014OCF 3 , halogen, or NR 6 R 7 ; R 8  is H or \u2014CH 3 ; R 9  is H or \u2014C 1 -C 3 alkyl; HET(2) is a 5-membered heterocyclic ring having 1-3 heteroatom groups which are each independently N, NH, O, or S, optionally having one group \u2014C(\u2550O), and optionally having 1-3 double bonds; A 3  is phenyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclohexenyl, cyclopentyl, cyclopentenyl, or HET(1), wherein HET(1) is pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, oxazolyl, pyrrolyl, thienyl, furyl, or a 5-6-membered heterocyclic ring having 1-2 heteroatom groups which are independently \u2014N\u2014, \u2014NH\u2014 or \u2014O\u2014, and optionally one \u2014C(\u2550O)\u2014 group, wherein A 3  is optionally substituted with 1-2 groups which are each independently CH 3 , CF 3 , \u2014OCH 3 , \u2014OCF 3 , \u2014OH, or halogen, and is optionally substituted with 1 group which is \u2014CO 2 R 8 , \u2014C(O)NR 6 R 7 , \u2014SO 2 NR 6 R 7 , HET(2), or \u2014C(O)NR 6 cyclopropyl wherein cyclopropyl is optionally substituted with 1-3 substituents which are independently selected from 1-3 halogens, one CH 3  and one \u2014CN, and HET(2) is optionally substituted with 1-2 substituent groups which are each independently CH 3 , CF 3 , \u2014OCH 3 , \u2014OCF 3 , halogen, or NR 6 R 7 ; A 2  is phenyl or HET(1) wherein A 2  is substituted with 1-3 substituent groups which are each independently CF 3 , CH 3 , F, C 1 , \u2014CN, or cyclopropyl; and a is 0 or 1.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 86.0
- Lexical Diversity: 1.63043
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14908180', '13660010', '15329284', '15104351', '15028306']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8414174496215068
- 35 USC 102 Novelty (BERT): 0.5705619289461397
- Combined Prediction Score: 0.8143318975539701
- Mean Citation Score: 434.067694
- Max Citation Score: 454.36414
- Similarity Product: 445.9032232923509

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test