PATENT CLAIM ANALYSIS

Application Number: 16364014
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["436", "518000"]

Abstract:
This disclosure relates to compositions, devices and methods of detecting the presence of molecules and optionally quantifying forces associated with molecular interactions on the surface of cells and other lipids. In certain embodiments, devices disclosed herein can be used to detect forces through cell surface receptors. In other embodiments, the devices can be used to detect the presence or absence of molecules on cells or other particles or detect the changes in cell morphology after ligand receptor binding.

Claim (Index 1):
A method of detecting a light signal from a cell receptor binding a ligand comprising the steps of:\n a) exposing a device to a cell containing a receptor to the ligand under conditions such that the device is connected to the cell membrane comprising the receptor of the ligand; wherein the device comprises: i) a ligand; ii) an elastic linker molecule having a first end and a second end, wherein the linker is linked to the ligand at the first end; iii) a surface connected to the elastic linker at the second end; iv) a first fluorescent molecule conjugated to the ligand wherein the fluorescent molecule is configured to move its position relative to the surface when the ligand moves; and v) a quencher fixed to the surface, wherein the elastic linker comprises ethylene glycol, polypeptide, or polynucleotide; and wherein the receptor is binding and pulling the ligand away from the surface to extend the elastic linker from the relaxed conformation removing the first fluorescent molecule from proximity to the quencher producing a light signal; and b) detecting the light signal.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 99.0
- Lexical Diversity: 1.71429
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15505846', '10062064', '14293766', '14589467', '13455674']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6350675942967314
- 35 USC 102 Novelty (BERT): 0.4826809819838676
- Combined Prediction Score: 0.6198289330654451
- Mean Citation Score: 194.086314
- Max Citation Score: 197.18323
- Similarity Product: 131.02173302371204

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test