PATENT CLAIM ANALYSIS

Application Number: 15779910
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["544", "132000"]

Abstract:
The present invention relates to a novel process for the preparation of intermediate of fosaprepitant dimeglumine. The present invention particularly relates to a process for the preparation of fosaprepitant dibenzyl ester, an intermediate of fosaprepitant dimeglumine, which is simple, easy to handle on commercial scale and efficient.

Claim (Index 1):
A process for the preparation of [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxyl-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-phosphonic acid bis(phenylmethyl) ester (fosaprepitant dibenzyl ester) of formula II, comprising the steps of, (a) obtaining a solution of fosaprepitant dibenzyl ester of formula II in at least one solvent or a mixture of solvents thereof, (b) adding an inorganic acid to the solution obtained in step (a), (c) concentrating the reaction mass obtained in step (b), (d) adding at least one solvent or a mixture of solvents thereof to the reaction mass obtained in step (c), (e) filtering the reaction mass obtained in step (d) to obtain a residue, Residue A, (f) adding at least one solvent or a mixture of solvents thereof to the residue obtained in step (e), (g) filtering the reaction mass obtained in step (1) to obtain a residue, Residue-B, (h) adding at least one solvent or a mixture of solvents thereof to the residue obtained in step (g), (i) filtering the reaction mass obtained in step (h), (j) concentrating the filtrate obtained in step (i) to yield fosaprepitantdibenzyl ester of purity 96%.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.67742
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14123290', '13003885', '15728972', '15165643', '14773397']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7374814464010448
- 35 USC 102 Novelty (BERT): 0.5185813280661702
- Combined Prediction Score: 0.7155914345675574
- Mean Citation Score: 275.33036400000003
- Max Citation Score: 328.53616
- Similarity Product: 300.5322643251705

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test