PATENT CLAIM ANALYSIS

Application Number: 15877597
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "052000"]

Abstract:
The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Claim (Index 80):
A method of treating a disease or disorder associated with NAD+ biosynthesis, comprising administering a compound, or a salt thereof, to a subject in need thereof; wherein the compound is represented by formula III: wherein W 1  and W 2  are independently selected from the substituents in Table 1, and\n each R 21  is independently H or (C 1 -C 8 )alkyl; \n each R 22  is independently H, R 21 , R 23  or R 24 , wherein each R 24  is independently substituted with 0 to 3 R 23 ; \n each R 23  is independently R 23a , R 23b , R 23c  or R 23d , provided that when R 23  is bound to a heteroatom, then R 23  is R 23c  or R 23d ; \n each R 23a  is independently F, Cl, Br, I, \u2014CN, \u2014N 3  or \u2014NO 2 ; \n each R 23b  is independently Y 21 ; \n each R 23c  is independently \u2014R 2x , \u2014OR 2x , \u2014N(R 2x )(R 2x ), \u2014SR 2x , \u2014S(O)R 2x ; \u2014S(O) 2 R 2x , \u2014S(O)(OR 2x ), \u2014S(O) 2 (OR 2x ), \u2014OC(\u2550Y 21 )R 2x , \u2014OC(\u2550Y 21 )OR 2x , \u2014OC(\u2550Y 21 )(N(R 2x )(R 2x )); \u2014SC(\u2550Y 21 )R 2x ; \u2014SC(\u2550Y 21 )OR 2x , \u2014SC(\u2550Y 21 )(N(R 2x )(R 2x )), \u2014N(R 2x )C(\u2550Y 21 )R 2x , \u2014N(R 2x )C(\u2550Y 21 )OR 2x , or \u2014N(R 2x )C(\u2550Y 21 )(N(R 2x )(R 2x )); \n each R 23d  is independently \u2014C(\u2550Y 21 )R 2x ; \u2014C(\u2550Y 21 )OR 2x  or \u2014C(\u2550Y 21 )(N(R 2x )(R 2x )); \n each R 2x  is independently H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, aryl, heteroaryl; or two R 2x  taken together with a nitrogen or oxygen to which they are both attached form a 3 to 7 membered heterocyclic ring wherein any one carbon atom of said heterocyclic ring can optionally be replaced with \u2014O\u2014, \u2014S\u2014 or \u2014NR 21 \u2014; and wherein one or more of the non-terminal carbon atoms of each said (C 1 -C 8 )alkyl may be optionally replaced with \u2014O\u2014, \u2014S\u2014 or \u2014NR 21 ; \n each R 24  is independently (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, or (C 2 -C 8 )alkynyl; \n each R 25  is independently R 24 , wherein each R 24  is substituted with 0 to 3 R 23  groups; \n each R 25a  is independently (C 1 -C 8 )alkylene, (C 2 -C 8 )alkenylene, or (C 2 -C 8 )alkynylene, any one of which said (C 1 -C 8 )alkylene, (C 2 -C 8 )alkenylene, or (C 2 -C 8 )alkynylene is substituted with 0-3 R 23  groups; \n each W 23  is independently W 24  or W 25 ; \n each W 24  is independently R 25 , \u2014C(\u2550Y 21 )R 25 , \u2014C(\u2550Y 21 )W 25 , \u2014SO 2 R 25 , or \u2014SO 2 W 25 ; \n each W 25  is independently carbocycle or heterocycle, wherein W 25  is independently substituted with 0 to 3 R 22  groups; and \n each Y 21  is independently O or S; and wherein the disease or disorder is a mitochondrial disease or disorder.

Metadata:
- Claim Count in Document: 119.0
- Percentile: 86.0
- Lexical Diversity: 1.81818
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15512388', '15492952', '15562336', '13991321', '13991328']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7188185320219102
- 35 USC 102 Novelty (BERT): 0.6055226393246038
- Combined Prediction Score: 0.7074889427521796
- Mean Citation Score: 314.0314259999999
- Max Citation Score: 537.07587
- Similarity Product: 461.2932539641446

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test