PATENT CLAIM ANALYSIS

Application Number: 16230412
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["514", "250000"]

Abstract:
This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

Claim (Index 1):
A compound of Formula: or a pharmaceutically acceptable salt, N-oxide, isotopic derivative, or prodrug, thereof; wherein:\n y is 0, 1, 2, 3, or 4; \n Z is S, CH 2 , CHR 12 , CR 12 R 13 , NH, or NR 12 ; \n  represents the presence or absence of a double bond; \n R is hydrogen, C 1 -C 6 alkyl, \u2014(C 0 -C 2 alkyl)(C 3 -C 8 carbocyclyl), \u2014(C 0 -C 2 alkyl)(C 3 -C 8 heterocyclyl), \u2014(C 0 -C 2 alkyl)(aryl), \u2014(C 0 -C 2 alkyl)heteroaryl), \u2014COOalkyl, \u2014COOarylalkyl, or \u2014COOH; \n each R 1  is independently alkyl, aryl, cycloalkyl, or haloalkyl, wherein each of said alkyl, cycloalkyl and haloalkyl groups optionally includes heteroatoms O, N, or S in place of a carbon in the chain and two R 1 's on adjacent ring atoms or on the same ring atom together with the ring atom(s) to which they are attached optionally form a 3-8-membered cycle; \n wherein the 3-8 membered cycle formed by combining two R 1 s with the atom(s) to which they are attached can be either a carbocycle or a heterocycle; \n and wherein the 3-8 membered cycle formed by combining two R 1 s with the atom(s) to which they are attached can be optionally substituted with one or more substituents selected from amino, \u2014NHR 14 , \u2014NR 14 R 15 , hydroxyl, OR 14 , R 6 , and R 2 ; \n R 7  is selected from \n or R 7  is selected from cycloalkyl, heterocycle, and alkyl, each of which cycloalkyl, heterocycle, and alkyl groups is optionally substituted with one or more substituents selected from amino, \u2014NHR 14 , \u2014NR 14 R 15 , hydroxyl, OR 14 , R 6 , and R 2 ; X 1 , X 2 , X 3 , X 4 , and X 5  are independently N or CR 8 , wherein at least one of X 1 , X 2 , X 3 , X 4 , and X 5  are CR 8 ; R 8  is selected independently at each instance from R 6  and R 2 , wherein one R 8  is R 2 ; R 2  is independently selected from -(alkylene) m -heterocyclo, -(alkylene) m -heteroaryl, -(alkylene) m -NR 3 R 4 , -(alkylene) m -C(O)\u2014NR 3 R 4 ; -(alkylene) m -C(O)\u2014O-alkyl; -(alkylene) m -O\u2014R 5 , -(alkylene) m -S(O) n \u2014R 5 , or -(alkylene) m -S(O) n \u2014NR 3 R 4  any of which may be optionally independently substituted with one or more R x  groups as allowed by valance, and wherein two R x  groups bound to the same or adjacent atom may optionally combine to form a ring; m is 0 or 1; n is 0, 1 or 2; R 3  and R 4  at each occurrence are independently selected from hydrogen, alkyl, cycloalkyl, heterocyclo, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkyl, arylalkyl, and heteroarylalkyl; or R 3  and R 4  together with the nitrogen atom to which they are attached may combine to form a heterocyclo ring; R 5  is independently selected at each occurrence from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkyl, arylalkyl, and heteroarylalkyl; R x  at each occurrence is independently selected from halo, cyano, nitro, oxo, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkyl, -(alkylene) m -OR 5 , -(alkylene) m -O-alkylene-OR 5 , -(alkylene) m -S(O) n \u2014R 5 , -(alkylene) m -NR 3 R 4 , -(alkylene) m -CN, -(alkylene) m -C(O)\u2014R 5 , -(alkylene) m -C(S)\u2014R 5 , -(alkylene) m -C(O)\u2014OR 5 , -(alkylene) m -O\u2014C(O)\u2014R 5 , -(alkylene) m -C(S)\u2014OR 5 , -(alkylene) m -C(O)-(alkylene) m -NR 3 R 4 , -(alkylene) m -C(S)\u2014NR 3 R 4 , -(alkylene) m -N(R 3 )\u2014C(O)\u2014NR 3 R 4 , -(alkylene) m -N(R 3 )\u2014C(S)\u2014NR 3 R 4 , -(alkylene) m -N(R 3 )\u2014C(O)\u2014R 5 , -(alkylene) m -N(R 3 )\u2014C(S)\u2014R 5 , -(alkylene) m -O\u2014C(O)\u2014NR 3 R 4 , -(alkylene) m -O\u2014C(S)\u2014NR 3 R 4 , -(alkylene) m -SO 2 \u2014NR 3 R 4 , -(alkylene) m -N(R 3 )\u2014SO 2 \u2014R 5 , -(alkylene) m -N(R 3 )\u2014SO 2 \u2014NR 3 R 4 , -(alkylene) m -N(R 3 )\u2014C(O)\u2014OR 5 )-(alkylene) m -N(R 3 )\u2014C(S)\u2014OR 5 , or -(alkylene) m -N(R 3 )\u2014SO 2 \u2014R 5 , wherein: said alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkyl; R 6  is selected independently at each instance from hydrogen, halogen, alkyl, alkenyl, alkynyl cycloalkyl, heterocyclo, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkyl, arylalkyl, and heteroarylalkyl; R 9  is selected from \u2014C(O)H, \u2014C(O)alkyl, \u2014C(S)alkyl, alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; R 10  and R 11  are selected from hydrogen, alkyl, \u2014NH 2 , \u2014NHR 12 , \u2014NR 12 R 13 , \u2014S(O)alkyl, and \u2014SO 2 alkyl; or R 10  and R 11  are selected from cycloalkyl, heterocycle, aryl, heteroaryl, arylalkyl, and heteroarylalkyl, each of which is optionally substituted with one or more substituents selected from amino, \u2014NHR 14 , \u2014NR 14 R 15 , hydroxyl, OR 14 , R 6 , and R 2 ; R 12  is selected from hydrogen, alkyl, alkenyl, alkynyl, \u2014C(O)H, \u2014C(O)alkyl, \u2014C(S)alkyl, aryl, \u2014SO 2 alkyl, heteroaryl, arylalkyl, and heteroarylalkyl; or R 12  is selected from cycloalkyl, heterocycle, aryl, heteroaryl, arylalkyl, and heteroarylalkyl, each of which is optionally substituted with one or more substituents selected from amino, \u2014NHR 14 , \u2014NR 14 R 15 , hydroxyl, OR 14 , R 6 , and R 2 ; R 13  is independently selected from hydrogen, alkyl, alkenyl, alkynyl, \u2014C(O)H, \u2014C(O)alkyl, \u2014C(S)alkyl, aryl, \u2014SO 2 alkyl, heteroaryl, arylalkyl, and heteroarylalkyl; or R 13  is selected from cycloalkyl, heterocycle, aryl, heteroaryl, arylalkyl, and heteroarylalkyl, each of which is optionally substituted with one or more substituents selected from amino, \u2014NHR 14 , \u2014NR 14 R 15 , hydroxyl, OR 14 , R 6 , and R 2 ; and R 14  and R 15  are independently selected from hydrogen, alkyl, alkenyl, alkynyl, \u2014C(O)H, \u2014C(O)alkyl, \u2014C(S)alkyl, aryl, \u2014SO 2 alkyl, heteroaryl, arylalkyl, and heteroarylalkyl.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 98.0
- Lexical Diversity: 1.07692
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16230388', '14690180', '15419642', '15288878', '12567258']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7990830820827587
- 35 USC 102 Novelty (BERT): 0.5896622316503272
- Combined Prediction Score: 0.7781409970395156
- Mean Citation Score: 399.841996
- Max Citation Score: 488.13474
- Similarity Product: 420.3506687072969

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test