PATENT CLAIM ANALYSIS

Application Number: 15895848
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "182000"]

Abstract:
Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

Claim (Index 1):
A method of therapeutically treating cancer, comprising:\n identifying a patient in need of therapeutic treatment of a cancer; and administering to the patient a therapeutically effective amount of a non-isotopically labeled and radio-stable cationic steroid antimicrobial (CSA) of Formula I, or a pharmaceutically acceptable salt thereof, in an amount so as to therapeutically treat the cancer by killing or reducing proliferation of cancerous cells: where,\n rings A, B, C, and D are independently saturated, or are fully or partially unsaturated, provided that at least two of rings A, B, C, and D are saturated; \n m, n, p, and q are independently 0 or 1; \n R 1  through R 4 , R 6 , R 7 , R 11 , R 12 , R 15 , R 16 , and R 18  are independently selected from the group consisting of hydrogen, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkyloxyalkyl, substituted or unsubstituted alkylcarboxyalkyl, substituted or unsubstituted alkylaminoalkyl, substituted or unsubstituted alkylaminoalkylamino, substituted or unsubstituted alkylaminoalkylaminoalkylamino, substituted or unsubstituted aminoalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylaminoalkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, oxo, linking group attached to a second CSA, substituted or unsubstituted aminoalkyloxy, substituted or unsubstituted aminoalkyloxyalkyl, substituted or unsubstituted aminoalkylcarboxy, substituted or unsubstituted aminoalkylaminocarbonyl, substituted or unsubstituted aminoalkylcarboxamido, substituted or unsubstituted di(alkyl)aminoalkyl, H 2 N\u2014HC(Q 5 )-C(O)\u2014O\u2014, H 2 N\u2014HC(Q 5 )-C(O)\u2014N(H)\u2014, substituted or unsubstituted azidoalkyloxy, substituted or unsubstituted cyanoalkyloxy, P.G.-HN\u2014HC(Q 5 )-C(O)\u2014O\u2014, substituted or unsubstituted guanidinoalkyloxy, substituted or unsubstituted quaternary ammonium alkylcarboxy, and substituted or unsubstituted guanidinoalkyl carboxy, where Q 5  is a side chain of an amino acid, and P.G. is an amino protecting group; and \n R 5 , R 8 , R 9 , R 10 , R 13 , R 14  and R 17  are independently deleted when one of rings A, B, C, or D is unsaturated so as to complete the valency of the carbon atom at that site, or R 5 , R 8 , R 9 , R 10 , R 13 , and R 14  are independently selected from the group consisting of hydrogen, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkyloxyalkyl, substituted or unsubstituted aminoalkyl, substituted or unsubstituted aryl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, oxo, linking group attached to a second CSA, substituted or unsubstituted aminoalkyloxy, substituted or unsubstituted aminoalkylcarboxy, substituted or unsubstituted aminoalkylaminocarbonyl, substituted or unsubstituted di(alkyl)aminoalkyl, H 2 N\u2014HC(Q 5 )-C(O)\u2014O\u2014, H 2 N\u2014HC(Q 5 )-C(O)\u2014N(H)\u2014, azidoalkyloxy, cyanoalkyloxy, P.G.-HN\u2014HC(Q 5 )-C(O)\u2014O\u2014, guanidinoalkyloxy, and guanidinoalkylcarboxy, where Q 5  is a side chain of an amino acid, and P.G. is an amino protecting group, \n provided that at least two of R 1-4 , R 6 , R 7 , R 11 , R 12 , R 15 , R 16 , R 17 , and R 18  are independently selected from the group consisting of substituted or unsubstituted aminoalkyl, substituted or unsubstituted aminoalkyloxy, substituted or unsubstituted alkylcarboxyalkyl, substituted or unsubstituted alkylaminoalkylamino, substituted or unsubstituted alkylaminoalkylaminoalkylamino, substituted or unsubstituted aminoalkylcarboxy, substituted or unsubstituted arylaminoalkyl, substituted or unsubstituted aminoalkyloxyaminoalkylaminocarbonyl, substituted or unsubstituted aminoalkylaminocarbonyl, substituted or unsubstituted aminoalkylcarboxyamido, quaternary ammonium alkylcarboxy, substituted or unsubstituted di(alkyl)aminoalkyl, H 2 N\u2014HC(Q 5 )-C(O)\u2014O\u2014, H 2 N\u2014HC(Q 5 )-C(O)\u2014N(H)\u2014, azidoalkyloxy, cyanoalkyloxy, P.G.-HN\u2014HC(Q 5 )-C(O)\u2014O\u2014, substituted or unsubstituted guanidinoalkyloxy, and substituted or unsubstituted guanidinoalkylcarboxy.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.32609
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14149675', '13615324', '14842582', '13615244', '14848819']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8595177632686415
- 35 USC 102 Novelty (BERT): 0.6401442735685537
- Combined Prediction Score: 0.8375804142986327
- Mean Citation Score: 639.1508240000003
- Max Citation Score: 688.5246
- Similarity Product: 563.0983077430128

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test