PATENT CLAIM ANALYSIS

Application Number: 16223556
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["514", "646000"]

Abstract:
A method of treating pain, e.g., acute post-operative pain, by administering to a human patient(s) a therapeutically effective dose of tramadol intravenously in a dosing regimen which includes one or more loading doses administered at shortened intervals as compared to dosing at steady-state is disclosed. In certain embodiments, the dose of tramadol is from about 45 mg to about 80 mg and the second (and optionally) third doses are intravenously administered at intervals of from about 2 to about 3 hours, and thereafter the tramadol is intravenously administered at a dosing interval of about 4 to about 6 hours, until the patient no longer requires treatment with tramadol. In preferred embodiments, the intravenous dosing regimen provides a Cmax and AUC of tramadol is similar to the Cmax and AUC of an oral dose of 100 mg tramadol HCl given every 6 hours. In certain preferred embodiments, the dosing regimen comprises 50 mg IV tramadol at Hour 0, followed by 50 mg at Hour 2, 50 mg at hour 4, and 50 mg every 4 hours thereafter (e.g., until the patient no longer requires treatment with tramadol).

Claim (Index 23):
The method of  claim 22 , further comprising administering the first dose of intravenous tramadol on first demand of analgesia postoperatively.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 98.0
- Lexical Diversity: 2.34831
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16223522', '15612665', '15622910', '15163111', '16007464']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8589849313662454
- 35 USC 102 Novelty (BERT): 0.6603489453286671
- Combined Prediction Score: 0.8391213327624876
- Mean Citation Score: 808.8858700000003
- Max Citation Score: 841.1109
- Similarity Product: 598.8314154100477

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test