PATENT CLAIM ANALYSIS

Application Number: 15763095
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["514", "171000"]

Abstract:
Bruton's tyrosine kinase (Btk) inhibitors have the following Formula (I):

Claim (Index 1):
A compound of Formula (I) having the following structure: wherein: A is N or CR 1 ; B, C, and D are each N or C\u2014H, with the proviso that only one or two of A, B, C, and D can be N; R 1  is hydrogen, amino, OH, CN, NHOH or CONH 2 ; R 2  is \u2014X-E is one of the followings:\n (1) X is O, OCR a R b , S(O), S(O) 2 , CR a R b , NR c (C\u2550O), C\u2550ONR c  or a bond; and E is a hydrogen, an aryl or a heteroaryl substituted with one to three R 5  substituents; or a 3-7 membered saturated or partially unsaturated carbocyclic ring, an 8-10 membered bicyclic saturated, partially unsaturated or aryl ring, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 7-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or \n (2) \u2014X-E is hydrogen, halogen, \u2014OR a , \u2014O(CH 2 ) 1-4 R a , \u2014CN, \u2014NO 2 ; \n R 4  and R 5  are each independently selected from the group consisting of hydrogen, halogen, hydroxy, cyano, OCF 3 , OCF 2 H, C 1-6  alkyl, optionally substituted with one to five fluorines, C 3-6  cycloalkyl, optionally substituted with one to five fluorines, C 1-4  alkoxy, optionally substituted with one to five fluorines, C 1-4  alkylthio, optionally substituted with one to five fluorines, C 1-4  alkylsulfonyl, optionally substituted with one to five fluorines, carboxy, C 1-4  alkyloxycarbonyl, and C 1-4  alkylcarbonyl; R a  and R b  are each independently hydrogen, fluorine, or C 1-3  alkyl, optionally substituted with one to five fluorines; R c  is hydrogen or C 1-3  alkyl, optionally substituted with one to five fluorines; R 3  is a group having a double bond, an isomer thereof, a tautomer thereof, a pharmaceutical acceptable solvate thereof, or a pharmaceutical acceptable prodrug thereof.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.14286
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13805471', '13780557', '15530681', '14376307', '15410716']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.843855069767037
- 35 USC 102 Novelty (BERT): 0.5380091119789882
- Combined Prediction Score: 0.8132704739882322
- Mean Citation Score: 394.870806
- Max Citation Score: 395.57306
- Similarity Product: 266.665341627214

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test