PATENT CLAIM ANALYSIS

Application Number: 16150345
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["544", "277000"]

Abstract:
Provided herein are processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide, alternatively named (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide, or a salt, solvate, hydrate, or isotopologue thereof.

Claim (Index 1):
A process for preparing a compound of Formula (I): or a salt, solvate, hydrate, or isotopologue thereof, comprising\n (a) contacting Compound 1 of the formula: \n or a salt, solvate, hydrate, or isotopologue thereof, with Compound 2 of the Formula: or a salt, solvate, hydrate, or isotopologue thereof, to provide Compound 3 of the Formula: or a solvate, hydrate, or isotopologue thereof;\n (b) contacting Compound 3, or a solvate, hydrate, or isotopologue thereof, with Compound 4 of the Formula: \n or a solvate, hydrate, or isotopologue thereof, to provide Compound 5 of the Formula: or a solvate, hydrate, or isotopologue thereof;\n (c) reducing Compound 5, or a salt, solvate, hydrate, or isotopologue thereof with a reducing agent and a catalyst, to provide Compound 6 of the Formula: \n or a solvate, hydrate, or isotopologue thereof; (d) contacting Compound 6 or a salt, solvate, hydrate, or isotopologue thereof, with 2,4,6-trichlorophenyl isothiocyanate, to provide Compound 7 of the Formula: or a solvate, hydrate, or isotopologue thereof; (e) contacting Compound 7 or a solvate, hydrate, or isotopologue thereof with ethylcarbodiimide hydrochloride, to provide a compound of Formula (I), or a solvate, hydrate, or isotopologue thereof; and (f) optionally converting the compound of Formula (I), or a solvate, hydrate, or isotopologue thereof, to a citrate salt of the compound of Formula (I).

Metadata:
- Claim Count in Document: 128.0
- Percentile: 97.0
- Lexical Diversity: 1.78947
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13277615', '14026794', '16150350', '15680024', '14327499']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7359768955597251
- 35 USC 102 Novelty (BERT): 0.5004406714498657
- Combined Prediction Score: 0.7124232731487392
- Mean Citation Score: 262.308802
- Max Citation Score: 271.0891
- Similarity Product: 187.68179238801

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test