PATENT CLAIM ANALYSIS

Application Number: 15926657
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "275000"]

Abstract:
A method of preventing or inhibiting L-cystine crystallization is disclosed, using the compounds of formula I: R 1a —[O] v -(-A-L-) m -A-[O] v —R 1b  wherein A, L, R 1a , R 1b , m, and v are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to L-cystine crystallization, such as comprising (but not limited to) kidney stones.

Claim (Index 1):
A method for preventing, inhibiting, or slowing the growth of L-cystine crystallization comprising administering an effective amount of a compound of formula I:\n R 1a \u2014[O] v -(-A-L-) m -A-[O] v \u2014R 1b  or a pharmaceutically acceptable salt, solvate, cocrystal, or prodrug thereof, and stereoisomers, tautomers and isotopic variants thereof; and wherein each A is independently each X and Y is independently S, S(O), S(O) 2 , or C(R 5 )q; each R 2a , R 2b , R 3a , R 3b , R 3c , R 3d , R 4a , R 4b  and R 5  is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted cycloalkyl; the subscript q is 1 or 2; the dotted bond is a single or a double bond; provided that when one of X and Y is S, S(O), or S(O) 2 , then the dotted bond is a single bond;\n L is \u2014O\u2014C 1 -C 6  alkylene-O\u2014, \u2014O-aryl-O\u2014, or a group \u2014O\u2014(CH 2 \u2014CH 2 \u2014O\u2014) t \u2014; the subscript t is 1-10; the subscript m is 0-10; and \n each R 1a  and R 1b  is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted cycloalkyl; and each subscript v is 0 or 1.

Metadata:
- Claim Count in Document: 307.0
- Percentile: 90.0
- Lexical Diversity: 1.56452
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13491816', '13902114', '12953096', '13989973', '14343410']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7824548067910391
- 35 USC 102 Novelty (BERT): 0.5851488093695008
- Combined Prediction Score: 0.7627242070488853
- Mean Citation Score: 371.147288
- Max Citation Score: 496.9118
- Similarity Product: 441.9526467357636

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test