PATENT CLAIM ANALYSIS

Application Number: 15862997
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["435", "239000"]

Abstract:
Nucleic acids encoding Parvoviral Rep proteins with a mutated nuclear localization signal (NLS) are provided. Also provided is a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein with a mutated zinc finger domain and a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein comprising an amino acid mutation at position 43, 57, 79, 97, 120, 179, 305, 484, 493 or 571 with reference to SEQ ID NO: 2. Nucleic acid constructs and cells, such as insect cells, comprising the nucleic acids are provided as well as a method for producing a recombinant Parvoviral virion using the nucleic acids.

Claim (Index 1):
A nucleic acid construct comprising a nucleotide sequence encoding an adeno-associated virus (AAV) Rep protein, the nucleic acid sequence being operably linked to an expression control sequence for expression of the AAV Rep protein in an insect cell, wherein at least one of the nuclear localization signals (NLS) of the AAV Rep protein comprises a mutation, thereby reducing the ability of the mutated NLS to function as an NLS.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 86.0
- Lexical Diversity: 1.79104
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13583920', '14149953', '12918460', '12670780', '13945505']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6671910240648111
- 35 USC 102 Novelty (BERT): 0.6709940482332793
- Combined Prediction Score: 0.6675713264816581
- Mean Citation Score: 565.419026
- Max Citation Score: 823.82
- Similarity Product: 626.3869121575357

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test