PATENT CLAIM ANALYSIS

Application Number: 15911935
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "211000"]

Abstract:
The compounds of formula (I) are inhibitors of SSAO activity wherein V, W, X, Y, Z, R 1  and R 2  are as defined in the claims.

Claim (Index 2):
A compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof: Wherein: Y is selected from hydrogen, hydroxyl, \u2014NH 2 , \u2014NH\u2014C 1-4 -alkyl, \u2014NH-halo-C 1-4 -alkyl, or \u2014C 1-4 -alkoxy; Z is selected from hydrogen, halogen, hydroxyl, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, C 1-4 -alkoxy, halo-C 1-4 -alkoxy, \u2014CONH 2 , \u2014SO 2 NH 2 , \u2014NH 2 , \u2014NHC 1-4 -alkyl, or \u2014NHhalo-C 1-4 -alkyl; R 1  is a phenyl ring, or a 5 or 6-membered heteroaryl ring, either ring being optionally substituted with one or more substituents selected from halogen, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, \u2014OR 5 , \u2014NR 6 C(O)OR 5 , \u2014NR 6 C(O)R 5 , \u2014NR 6 C(O)NR 4A R 4B , \u2014C(O)NR 4A R 4B , C(O)R 5 , \u2014C(O)OR 5 , and \u2014NR 6 S(O) 2 R 5 ; wherein R 4A , R 4B  R 5  and R 6  are each independently selected from hydrogen, C 1-4 -alkyl or halo-C 1-4 -alkyl, or R 4A  and R 4B  together with the nitrogen to which they are attached form a 3-7 membered cyclic amino group, optionally substituted by one or more substituents selected from: halogen, hydroxyl, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, C 1-4 -alkoxy, halo-C 1-4 -alkoxy, \u2014CONH 2 , \u2014SO 2 NH 2 , \u2014NH 2 , \u2014NHC 1-4 -alkyl, \u2014NHhalo-C 1-4 -alkyl; X is \u2014C(R 2 )\u2550; R 2  is selected from hydrogen, halogen, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, \u2014OR 5 , \u2014NR 4A R 4B , \u2014NR 6 C(O)OR 5 , \u2014NR 6 C(O)R 5 , \u2014NR 6 C(O)NR 4A R 4B , \u2014C(O)NR 4A R 4B , \u2014C(O)R 5 , \u2014C(O)OR 5 , \u2014SO 2 R 5 , \u2014SO 2 NR 4A R 4B  and \u2014NR 6 S(O) 2 R 5 ; W is a phenyl ring or a 5 or 6-membered heteroaryl ring, either ring being optionally substituted with one or more substituents selected from halogen, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, \u2014OR 5 , \u2014NR 7A R 7B , \u2014NR 6 C(O)OR 5 , \u2014NR 6 C(O)R 5 , \u2014NR 6 C(O)NR 7A R 7B , \u2014SO 2 R 5 , \u2014SO 2 NR 7A R 7B  and \u2014NR 6 S(O) 2 R 5 ; R 7A  and R 7B  are independently hydrogen, CO 1-4 -alkyl or halo-C 1-4 -alkyl. V is selected from a bond, \u2014O\u2014, \u2014N(R 6 )\u2014, \u2014(C\u2550O)\u2014, \u2014CONR 6 \u2014, \u2014NR 6 C(O)\u2014, or \u2014C 1-4 -alkylene-, wherein the C 1-4 -alkylene group is optionally substituted by halogen, and wherein any one of the carbon atoms of the C 1-4 -alkylene group may be replaced by \u2014O\u2014 or \u2014N(R 6 )\u2014; R 3  is hydrogen, or a 3-7 membered heterocyclic ring, or 3-7 membered cycloalkyl ring selected from cyclopropyl, cyclopentyl or cyclohexyl, or a 5 or 6-membered heteroaryl ring, any one of the rings being optionally substituted with one or more substituents selected from halogen, oxo, hydroxyl, cyano, C 1-4 -alkyl, halo-C 1-4 -alkyl, cyano-C 1-4 -alkyl, \u2014OR 5 , \u2014NR 4A R 4B , \u2014NR 6 C(O)OR 5 , \u2014NR 6 C(O)R 5 , \u2014NR 6 C(O)NR 4A R 4B , \u2014C(O)NR 4A R 4B , \u2014C(O)R 5 , \u2014C(O)OR 5 , \u2014SO 2 R 5 , \u2014SO 2 NR 4A R 4B  and \u2014NR 6 S(O) 2 R 5 ; PROVIDED THAT when \u2014R 3  is H, R 1  is not a phenyl ring substituted with one \u2014OCH 3 .

Metadata:
- Claim Count in Document: 8.0
- Percentile: 90.0
- Lexical Diversity: 1.25
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15592556', '14208056', '15215026', '14774749', '13634732']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8521687819103198
- 35 USC 102 Novelty (BERT): 0.6313216262796819
- Combined Prediction Score: 0.830084066347256
- Mean Citation Score: 525.897152
- Max Citation Score: 575.74603
- Similarity Product: 572.2732729435324

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test