PATENT CLAIM ANALYSIS

Application Number: 16196572
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-10
Patent Classification: ["424", "062000"]

Abstract:
A method for inhibiting hair growth in mammals using compositions containing FP receptor antagonists (e.g., prostaglandin F analogs that are block activation of the FP receptor). The compositions can be applied topically to the skin and/or hair. The compositions can arrest hirsutism or hypertrichosis, reverse hirsutism and hypertrichosis, and further prevent hair growth. These compositions can also be used to protect hair from chemical or radiation-induced alopecia or hair loss. These compositions can also be used to inhibit pigmentation of the hair or skin.

Claim (Index 39):
A pharmaceutical composition comprising:\n A) a compound of Formula I, Formula II, or an 11-deoxy-16-fluoro PGF 2\u03b1  analog of Formula II; B) a carrier; and C) at least one activity enhancer selected from the group consisting of:\n i) a hair growth inhibitor selected from the group consisting of eflornithine, advanced glycation end products (AGE's), lysine, extracts of  Tetraselmis  species, fibroblast growth factor (FGF)18, cytotoxic lectin, trypsin, extract of  Juniperus  genus, malt extract, extract of ginger root, toxalbumins, inhibitors of cysteine pathway enzymes, inhibitors of nitric oxide synthetase, ornithine amino transferase inhibitors, cyclooxygenase inhibitors, and 5-lipoxygenase inhibitors; \n ii) a hirsutism treatment agent selected from the group consisting of spironolactone, botulinum toxin, cyproterone acetate, flutamide, bicalutamide, inhibitors of 5-alpha reductase, N,N-diethyl-4-methyl-3-oxo-4-aza-5\u03b1-androstane-17\u03b2-carboxamide, PTHR1 receptor ligands, ketaconazole, estrogen receptor modulators, progesterone, estrogen, RU58841, neuropeptide Y receptor antagonists, thiazolidinedione derivatives, metformin, cyoctol (6-(5-methoxy-1-heptyl)-bicyclo (3,3,0)octan-3-one], extracts of  Serenoa repens, Epilobium  species,  Cucurbita pepo, Urtica dioica, Calluna vulgaris, Populus  species, and  Barosma  species; \n iii) a preventative of chemotherapy-related hair loss or radiation-related hair loss; and \n iv) a penetration enhancer; \n wherein R is selected from the group consisting of CO 2 H, C(O)NHOH, CO 2 R 1 , CH 2 OH, S(O) 2 R 1 , C(O)NHR 1 , P(O)(OR 1 ) R 2 , C(O)NHS(O) 2 R 1 , and tetrazole; R 1  and R 2  are independently selected from the group consisting of a hydrogen atom, monovalent hydrocarbon groups, substituted monovalent hydrocarbon groups, aromatic groups, substituted aromatic groups, carbocyclic groups, substituted carbocyclic groups, heterogeneous groups, substituted heterogeneous groups, heterocyclic groups, substituted heterocyclic groups, heteroaromatic groups, and substituted heteroaromatic groups; W is \u2014CH 2 \u2014, \u2014O\u2014, or \u2014S(O) 2 \u2014; and X is halogen, lower alkyl, alkoxy, or hydrogen.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 98.0
- Lexical Diversity: 1.70909
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14605674', '14605664', '15485298', '11565297', '12535513']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6932719597907552
- 35 USC 102 Novelty (BERT): 0.538302612761158
- Combined Prediction Score: 0.6777750250877954
- Mean Citation Score: 336.127964
- Max Citation Score: 398.0999
- Similarity Product: 249.21214581963417

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test