PATENT CLAIM ANALYSIS

Application Number: 15884974
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "150000"]

Abstract:
The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 2 ′, and X are as defined as set forth in the specification, for use in treating cognitive deficits and/or psychiatric disorders, such as those associated with neurological or neurodegenerative disorders, psychiatric or mood disorders, and HIV-associated neurocognitive disorders (HAND). Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON).

Claim (Index 1):
A method for treating a subject having a cognitive deficit or psychiatric disorder, the method comprising administering to the subject a compound having formula (I): or a pharmaceutically acceptable salt thereof, wherein: X is selected from the group consisting of a bond, \u2014O\u2014, and \u2014(CH 2 ) n \u2014, wherein n is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, and 8; R 1  is selected from the group consisting of C 1-6  alkyl and substituted C 1-6  alkyl; R 2  is \u2014C(\u2550O)\u2014O\u2014(CR 3 R 4 ) m \u2014O\u2014C(\u2550O)\u2014R 10 ; R 2 \u2032 is selected from the group consisting of H, C 1 -C 6  alkyl, and substituted C 1 -C 6  alkyl; each R 3  and R 4  is independently H, C 1 -C 6  alkyl, substituted C 1 -C 6  alkyl, aryl, substituted aryl, \u2014(CR 3 R 4 ) m \u2014NR 5 R 6 , or m is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, and 8; R 5  and R 6  is independently H or alkyl; and R 10  is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, monosaccharide, acylated monosaccharide, aryl, substituted aryl, heteroaryl, and substituted heteroaryl, in an amount effective to treat the cognitive deficit or psychiatric disorder.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 86.0
- Lexical Diversity: 1.57627
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15885147', '15502105', '15885258', '14655878', '14898773']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6973083881118799
- 35 USC 102 Novelty (BERT): 0.5234384823793556
- Combined Prediction Score: 0.6799213975386275
- Mean Citation Score: 276.38147999999995
- Max Citation Score: 323.95404
- Similarity Product: 278.6387304910112

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test