PATENT CLAIM ANALYSIS

Application Number: 15891987
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["800", "003000"]

Abstract:
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.

Claim (Index 1):
A mouse that expresses a single rearranged human immunoglobulin light chain variable (V L ) region derived from a rearranged germline variable region sequence that comprises a human V L  gene segment derived from a human V\u03ba3-20 gene segment and\n a human immunoglobulin heavy chain variable (V H ) region cognate with said V L  region wherein the V H  region comprises a human V H  segment derived from a segment selected from V H 6-1, V H 1-2, V H 1-3, V H 2-5, V H 3-7, V H 1-8, V H 3-9, V H 3-11, V H 3-13, V H 3-15, V H 1-18, V H 3-20, V H 3-21, V H 3-23, V H 1-24, V H 2-26, V H 4-28, V H 3-30, V H 4-31, V H 3-33, V H 4-34, V H 4-39, V H 3-43, V H 1-46, V H 3-48, V H 3-49, V H 5-51, V H 3-53, V H 1-58, V H 4-59, V H 4-61, V H 3-64, V H 3-66, V H 1-69, V H 2-70, V H 3-72, and V H 3-73.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 88.0
- Lexical Diversity: 1.84932
- Patent Class: 800.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14473970', '13798455', '15700973', '13566765', '14961642']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6674267687669072
- 35 USC 102 Novelty (BERT): 0.629722999114856
- Combined Prediction Score: 0.6636563918017021
- Mean Citation Score: 606.051858
- Max Citation Score: 678.062
- Similarity Product: 551.9075559961797

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test