PATENT CLAIM ANALYSIS

Application Number: 15754009
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "049000"]

Abstract:
Provided is a preparation method of a composition enriched in compound S p -1. The method performs isomer separation on a reaction product from the first step, and then performs a two-step chemical synthesis, so as to prepare a composition comprising high-purity compound S p -1, wherein the HPLC purity of the single isomer S p -1 is 90% or more. Provided is a composition enriched in compound S p -1. The composition has an inhibitory effect on tumor cell proliferation in vitro significantly higher than that of NUC-1031 and compound R p -1. Also provided are the use of the composition, and a pharmaceutical composition comprising the composition and at least one pharmaceutically acceptable excipient.

Claim (Index 27):
A method for preparing a drug for the treatment of cancer using the composition enriched in compound Sp-1 according to  claim 14 , wherein said cancer includes pancreatic cancer, advanced solid tumors, ovarian tumor, non-small cell lung cancer, breast cancer, bladder cancer, cervical cancer, mesothelioma, esophageal cancer, gastric cancer, colorectal cancer, liver cancer, cholangiocarcinoma, nasopharyngeal cancer, testicular cancer, lymphoma, or head and neck cancer.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 88.0
- Lexical Diversity: 1.8
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15754318', '14970588', '13302409', '12671287', '11110203']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7184025211328294
- 35 USC 102 Novelty (BERT): 0.5126880130689665
- Combined Prediction Score: 0.6978310703264432
- Mean Citation Score: 189.315704
- Max Citation Score: 264.45383
- Similarity Product: 196.45975908060788

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test