PATENT CLAIM ANALYSIS

Application Number: 15914351
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "345000"]

Abstract:
The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R 1 , R 2 , R 3 , R 4 , m and n are as described herein.

Claim (Index 1):
A compound of formula I: wherein A is a carbocycle or heterocycle; X is alkylene, NR 4 C(O), NR 4 C(S), N(C(O)R 1 )C(O), NR 4 SO, NR 4 SO 2 , NR 4 C(O)NH, NR 4 C(S)NH, C(O)NR 4 , C(S)NR 4 , NR 4 PO or NR 4 PO(OH); Y is absent, CHR 4 , O, S, SO, SO 2  or NR 4 ; R 1  is selected from the group consisting of alkyl, a carbocycle or a heterocycle each of which is optionally substituted with hydroxyl, halogen, amino, carboxyl, amidino, guanidino, carbonyl, nitro, cyano, acyl, alkyl, haloalkyl, sulfonyl, sulfinyl, alkoxy, akylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, a carbocycle or a heterocycle; wherein said amino, amidino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, alkylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, carbocycle and heterocycle substituent is optionally substituted with, halogen, haloakyl, hydroxyl, carboxyl, carbonyl, or an amino, alkyl, alkoxy, acyl, sulfonyl, sulfinyl, phosphinate, carbocycle or heterocycle that is optionally substituted with hydroxyl, carboxyl, carbonyl, amino, halogen, haloalkyl, alkyl, alkoxy, alkylthio, sulfonyl, sulfinyl, acyl, a carbocycle or a heterocycle; R 2  is halogen, hydroxyl, alkyl, acyl or alkoxy, wherein each alkyl, acyl and alkoxy is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; R 3  is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, sulfinyl, sulfonyl, a carbocycle or a heterocycle wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, sulfinyl, sulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, sulfonyl or alkoxy; R 4  is H or alkyl; m is 0-3; n is 0-3; and salts and solvates thereof.

Metadata:
- Claim Count in Document: 66.0
- Percentile: 90.0
- Lexical Diversity: 1.2619
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14575018', '12960609', '15015586', '11217663', '12093530']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8463632119674749
- 35 USC 102 Novelty (BERT): 0.5831550533481287
- Combined Prediction Score: 0.8200423961055403
- Mean Citation Score: 493.964488
- Max Citation Score: 518.9480599999998
- Similarity Product: 392.4663605261586

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test