PATENT CLAIM ANALYSIS

Application Number: 15987286
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-01
Patent Classification: ["435", "071200"]

Abstract:
An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a combination thereof is provided. Cells having a gene encoding a modified FX protein are provided, wherein the cells exhibit a reduced ability to fucosylate a glycoprotein at a first temperature, but exhibit the ability to fucosylate the glycoprotein at a second temperature. Methods and compositions for making glycoproteins with reduced fucosylation are provided.

Claim (Index 38):
A method of determining the level of fucosylation of a glycoprotein by cells comprising:\n a) culturing the cells in the absence of external fucose, wherein the cells comprise a modified fucosylation pathway enzyme, and wherein the cells express a glycoprotein; b) detecting the amount of fucosylated glycoprotein in the cell culture of step a); c) culturing the cells of step a) in the presence of external fucose; d) detecting the amount of fucosylated glycoprotein in the cell culture of step c); and e) determining whether the level of fucosylation of the glycoprotein is reduced in the absence of external fucose.

Metadata:
- Claim Count in Document: 161.0
- Percentile: 93.0
- Lexical Diversity: 1.90385
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15378670', '14963178', '13779952', '12791637', '14402837']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7432053588339415
- 35 USC 102 Novelty (BERT): 0.698775809030106
- Combined Prediction Score: 0.7387624038535578
- Mean Citation Score: 766.1628440000003
- Max Citation Score: 884.0967400000003
- Similarity Product: 708.8586595772031

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test