PATENT CLAIM ANALYSIS

Application Number: 16276331
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "247000"]

Abstract:
The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT 2A  receptor, the serotonin transporter (SERT), pathways involving the dopamine D 1  and D 2  receptor signaling system, and/or the μ-opioid receptor.

Claim (Index 1):
A method for the treatment or prophylaxis of a central nervous system disorder, comprising administering to a patient in need thereof a compound of a Formula wherein: X is \u2014NH\u2014 or \u2014N(CH 3 )\u2014; L is selected from O, NH, NR a , and S; Z is \u2014CH(O\u2014R 1 )\u2014, \u2014O\u2014 or \u2014C(O)\u2014; R 1  is H, \u2014C(O)\u2014C 1-21  alkyl (e.g., \u2014C(O)\u2014C 1-5 alkyl, \u2014C(O)\u2014C 6-15  alkyl or \u2014C(O)\u2014C 16-21  alkyl), preferably said alkyl is a straight chain, optionally saturated or unsaturated and optionally substituted with one or more hydroxy or C 1-22  alkoxy (e.g., ethoxy) groups, for example R 1  is C(O)\u2014C 3  alkyl, \u2014C(O)C 6  alkyl, \u2014C(O)\u2014C 7  alkyl, \u2014C(O)\u2014C 9  alkyl, \u2014C(O)\u2014C 11  alkyl, \u2014C(O)\u2014C 13  alkyl or \u2014C(O)\u2014C 15  alkyl; R a  is:\n halogen, C 1-4  alkyl, C 2-4  alkenyl, C 2-4  alkynyl, or C 3-6  cycloalkyl, each of which can be independently substituted with up to three independently selected R b  groups, for example C 1-3  haloalkyl or C 1-3  hydroxyalkyl; or \n aryl optionally substituted with up to five independently selected R b ; and \n each R b  is independently selected from H, halogen, NH 2 , NO 2 , OH, C(O)OH, CN, SO 3 , and C 1-4  alkyl; in free or salt form; optionally in an isolated or purified free or salt form; wherein the disease or disorder is selected from obsessive-compulsive disorder (OCD), obsessive-compulsive personality disorder (OCPD), general anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, compulsive gambling disorder, compulsive eating disorder, body dysmorphic disorder, hypochondriasis, pathological grooming disorder, kleptomania, pyromania, attention deficit-hyperactivity disorder (ADHD), attention deficit disorder (ADD), impulse control disorder, and related disorders, and pain disorder or conditions associated with pain, such as cephalic pain, neuropathic pain, idiopathic pain, chronic pain, fibromyalgia, and chronic fatigue, and related disorders, opiate dependency, cocaine dependency, amphetamine dependency, alcohol dependency, and combinations thereof.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 99.0
- Lexical Diversity: 1.37736
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15660615', '15629481', '13642652', '14627968', '16056143']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8016737927993053
- 35 USC 102 Novelty (BERT): 0.5442935345796815
- Combined Prediction Score: 0.7759357669773429
- Mean Citation Score: 316.946048
- Max Citation Score: 368.0655
- Similarity Product: 245.7291407859921

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test