PATENT CLAIM ANALYSIS

Application Number: 15744207
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "314000"]

Abstract:
The present invention relates to the use of amitriptyline as an inhibitor of connexin hemichannels (HC) in the Central Nervous System (CNS). This HC-blocking agent is advantageously used to treat disorders involving misregulated HC (notably neuropathic pain, neurodegenerative disorders, ischemic brain injury and inflammatory intestinal conditions). Additionally, the invention provides a method to enhance the therapeutic effect of amitriptyline for its common indications. The method of the invention involves combining amitriptyline with another HC-blocking agent, mefloquine.

Claim (Index 2):
The therapeutic composition according to  claim 1 , for use for preventing and/or treating Major depressive disorder (MDD), post-traumatic stress disorder (PTSD), anxiety, generalized anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder, neuropathic pain, resistant pain, fibromyalgia, smoking cessation, chronic musculoskeletal pain, akynesia in Parkinson's disease, cataplexy, migraine, Parkinson's disease, vasomotor symptoms of menopause, premenstrual dysphoric disorder (PMDD), restless syndrome (Willis-Ekbom disease), hypersalivation (drooling, hypersialorrhea), hypersalivation (drooling, hypersialorrhea) in amyotrophic lateral sclerosis, bipolar I disorder, bulimia, obsessive-compulsive disorder (OCD), fatigue, Alzheimer's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, dementia with Lewy bodies, multiple system atrophy, stress, depression, depression in Parkinson disease and in dementia with Lewy bodies, schizophrenia, autism, insomnia, nocturnal enuresis, nocturnal terrors, sleep bruxism, sleep disorders in fibromyalgia, breathing disorders, REM sleep disorders, sleep apnea, or fibrositis, in a subject in need thereof.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 86.0
- Lexical Diversity: 1.47541
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14907221', '11295730', '13420111', '15834428', '14833041']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.702849037188167
- 35 USC 102 Novelty (BERT): 0.5427381679606063
- Combined Prediction Score: 0.686837950265411
- Mean Citation Score: 288.85656
- Max Citation Score: 393.6475
- Similarity Product: 240.88258452251551

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test