PATENT CLAIM ANALYSIS

Application Number: 15893373
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["435", "006100"]

Abstract:
Methods and compositions are provided for identifying any of the presence, location and phasing of methylated and/or hydroxymethylated cytosines in nucleic acids including long stretches of DNA. In some embodiments, the method may comprise reacting a first portion (aliquot) of a nucleic acid sample with a dioxygenase and optionally a glucosyltransferase in a reaction mixture containing the nucleic acid followed by a reaction with a cytidine deaminase to detect and optionally map  5m C in a DNA. Optionally, a second portion can be reacted with glucosyltransferase followed by reaction with a cytidine deaminase to detect and optionally map  5hm C in a DNA.

Claim (Index 7):
The method according to  claim 5 , further comprising: comparing the sequences obtained from the second reaction product and the reference sequence and optionally the third reaction product to determine which cytosines (Cs) in the nucleic acid sample are unmodified and optionally which of the modified cytosine are methylated or hydroxymethylated

Metadata:
- Claim Count in Document: 14.0
- Percentile: 88.0
- Lexical Diversity: 1.7619
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15441431', '15771275', '13827885', '14806048', '14110007']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6566144345434374
- 35 USC 102 Novelty (BERT): 0.6510002237052233
- Combined Prediction Score: 0.656053013459616
- Mean Citation Score: 522.9715480000001
- Max Citation Score: 756.8426
- Similarity Product: 587.6973361732603

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test