PATENT CLAIM ANALYSIS

Application Number: 15966436
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-01
Patent Classification: ["424", "489000"]

Abstract:
Embodiments of the disclosure relate generally to formulations, methods of treatment, kits, and dosage forms for treating inflammatory disorders, including atopic dermatitis, or cancer, the formulations comprising an active pharmaceutical ingredient. The formulation provided comprises granules, wherein the granules comprise: micronized active ingredient; one or more granulation binders; one or more fillers; one or more disintegrants; and one or more antioxidants. In one embodiment, the methods of treatment include orally administering the active ingredient to a subject suffering from atopic dermatitis, where the active ingredient is in an amount of about 20 mg to about 80 mg.

Claim (Index 33):
A dosage form for treating one or more diseases characterized by the dysregulation of the Syk/JAK pathway, the dosage form comprising micronized granules and extragranular components compressed into a tablet, and wherein:\n the micronized granules comprise: an active ingredient; one or more granulation binders; one or more fillers; one or more disintegrants; and one or more antioxidants; the extragranular components comprise one or more tableting fillers, one or more disintegrants, one or more lubricants, and optionally one or more surfactants; the active ingredient is a compound of Formula (I) or a pharmaceutically acceptable salt, enantiomer or prodrug thereof, wherein R1 is a 6-membered ring of Formula (II): wherein R3 is H, OH, C(O)OH, C1 to C6 alkyl or (C1 to C6) alkyl CN; and wherein R2 is a benzene ring of Formula (III): wherein R4 is a 6-membered ring of Formula (IV): wherein R5 is N or CH and R6 is a hydroxyl group, methanol group, or ethanol group, and wherein the formulation has a total API degradation impurity level not above about 0.6% of the total active ingredient amount after storage at 1 week at 40\u00b0 C./75% RH in an open container.

Metadata:
- Claim Count in Document: 78.0
- Percentile: 91.0
- Lexical Diversity: 1.78125
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15909779', '14453129', '13491069', '12940808', '15060010']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6400067947294877
- 35 USC 102 Novelty (BERT): 0.5033169242403587
- Combined Prediction Score: 0.6263378076805749
- Mean Citation Score: 235.29096200000004
- Max Citation Score: 246.47133
- Similarity Product: 167.3182511294496

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test