PATENT CLAIM ANALYSIS

Application Number: 15778046
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-02
Patent Classification: ["424", "204100"]

Abstract:
The invention features lentiviral transfer vectors that include heterologous nucleic acids to be introduced into a cell. The lentiviral transfer vector may be characterized by the following features: (a) including a cytomegalovirus (CMV) promoter; (b) including a polynucleotide encoding a partial gag protein that includes a mutated INS1 inhibitory sequence that reduces restriction of nuclear export of RNA; (c) not including a polynucleotide encoding the INS2, INS3, and INS4 inhibitory sequences of gag; (d) not including an SV40 origin of replication and/or an f1 origin of replication; (e) including a cPPT sequence that contains splice site; (f) including an EF1 alpha promoter with intact splice donor and acceptor sites; and (g) including hepatitis B PRE with mutation in start codon of X protein ORF.

Claim (Index 17):
The lentiviral transfer vector of  claim 1 , wherein said lentiviral transfer vector comprises:\n (i) a CMV promoter comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 52, (ii) an LTR R region comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 53, (iii) an LTR U5 region comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 54, (iv) a primer binding site comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 55, (v) a packaging signal comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 56, (vi) a major splice donor site comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 57, which is within said packaging signal, (vii) a partial gag sequence comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO:58, (viii) a partial env sequence comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO:60, (ix) a Rev-response element comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 62, (x) a partial env sequence comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO:64, (xi) a splice acceptor site comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 65, which is within said partial env sequence of part (x), (xii) a central polypurine tract comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 67, 92, or 93, (xiii) a splice acceptor site comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 68 or 94, which is within said central polypurine tract, (xiv) an EF1alpha promoter having at least 95% sequence identity to SEQ ID NO:71 or 95, (xv) a constitutive splice donor (CD) site comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 72, which is within said EF1alpha promoter, (xvi) a constitutive splice acceptor (CA) site comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 73, which is within said EF1alpha promoter, (xvii) a polynucleotide encoding an EGFP comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 76 and/or a transgene sequence, (xviii) a PRE sequence comprising a nucleic acid sequence having at least 95% sequence identity to SEQ ID NO: 78 or 79, (xix) a partial nef sequence comprising a nucleic acid sequence having at least 95% sequence identity to SEQ ID NO:83, (xx) a dU3 sequence comprising a nucleic acid sequencing having at least 95% sequence identity to SEQ ID NO:84, (xxi) an LTR R region comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 85, and (xxii) an LTR U5 region comprising a nucleic acid sequence having at least 95% identity to SEQ ID NO: 86.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 93.0
- Lexical Diversity: 1.73563
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15511973', '15866222', '14805236', '15105082', '14830392']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.757900632492666
- 35 USC 102 Novelty (BERT): 0.538933876573497
- Combined Prediction Score: 0.7360039569007492
- Mean Citation Score: 378.912568
- Max Citation Score: 399.0973
- Similarity Product: 269.61179220836163

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test