PATENT CLAIM ANALYSIS

Application Number: 15771909
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "277000"]

Abstract:
The present invention relates to a cyclohexene derivative, a preparation method thereof, and a pharmaceutical composition for preventing or treating metabolic disease containing the cyclohexene derivative as an active ingredient. The cyclohexene derivative according to the present invention increases the intracellular activity of cyclic adenosine monophosphate (cAMP) by activating G protein-coupled receptor 119 (GPR-119) and simultaneously exhibits weight loss and hypoglycemic effects by inducing the release of glucagon-like peptide-1 (GLP-1), which is a neuroendocrine protein, and thus can be useful as a pharmaceutical composition for preventing or treating metabolic diseases such as obesity, type 1 diabetes, type 2 diabetes, inadequate glucose tolerance, insulin resistance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia and syndrome X.

Claim (Index 2):
The compound of Formula 1 or the isomer or pharmaceutically acceptable salt thereof according to  claim 1 , wherein R 1  is a C 1-10  linear or branched alkoxycarbonyl, or an unsubstituted or substituted 5- to 10-membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O, and S, wherein:\n the substituted 5- to 10-membered heteroaryl is a 5- to 10-membered heteroaryl substituted with one or more C 1-10  linear or branched alkyl; R 2  is \u2014H or a halogen; R 3  is a C 1-10  linear or branched alkyl which is not substituted or substituted with one or more \u2014OH or a halogen, a C 1-10  linear or branched alkoxy, a C 1-10  linear or branched alkoxy C 1-10  linear or branched alkyl, an unsubstituted C 3-10  cycloalkyl, an unsubstituted 5- to 10-membered heteroaryl C 1-10  linear or branched alkyl containing one or more heteroatoms selected from the group consisting of N, O, and S, \u2014(CH 2 ) n NR 5 R 6 , \u2014(CH 2 ) m C(\u2550O)OR 7 , or \u2014(CH 2 ) p C(\u2550O)NR 8 R 9 , wherein: R 5  and R 6  are each independently \u2014H or -Boc R 7  is \u2014H, or a C 1-5  linear or branched alkyl, and R 8  and R 9  may be taken together with a nitrogen atom to which they are attached to form an unsubstituted or substituted 5- to 10-membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O, and S, wherein: the substituted 5- to 10-membered heterocycloalkyl is a 5- to 10-membered heterocycloalkyl substituted with one or more substituents selected from the group consisting of \u2014CN and \u2014C(\u2550O)NR 10 R 11 , and R 10  and R 11  are each independently \u2014H, n, m, and p is each independently an integer ranging from 1 to 5; R 4  is \u2014H, or a C 1-10  linear or branched alkyl which is not substituted or substituted with one or more \u2014OH; provided that R 3  and R 4  may be taken together with a nitrogen atom to which they are attached to form an unsubstituted 3- to 10-membered heterocycloakenyl containing one or more heteroatoms selected from the group consisting of N, O, and S, or an unsubstituted, substituted or fused 3- to 10-membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O, and S, wherein: the substituted 3- to 10-membered heterocycloalkyl is a 3- to 10-membered heterocycloalkyl substituted with one or more substituents selected from the group consisting of \u2014OH, \u2014CN, \u2550O, a halogen, a C 1-5  linear or branched alkyl which is not substituted or substituted with one or more \u2014OH, an unsubstituted C 3-10  cycloalkyl C 1-5  linear or branched alkyl, an unsubstituted C 3-10  cycloalkyl, an unsubstituted 3- to 10-membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O, and S, \u2014C(\u2550O)NR 12 R 13 , \u2014NR 14 R 15 , and \u2550NR 16 ; or substituted in a spiro fashion with a C 5-10  cycloakenyl fused with an unsubstituted C 6-10  aryl, or a 3- to 10-membered heterocycloalkyl which is not substituted or substituted with one or more -Boc and contains one or more heteroatoms selected from the group consisting of N, O, and S, R 12 , R 13 , R 14 , and R 15  are each independently \u2014H, or a C 1-5  linear or branched alkyl, and R 16  is \u2014OH, or a C 1-5  linear or branched alkoxy, provided that the fused 3- to 10-membered heterocycloalkyl is a 3- to 10-membered heterocycloalkyl fused with an unsubstituted C 6-10  aryl, and\n the substitution and fusion may occur at the same time in the case of the unsubstituted, substituted or fused 3- to 10-membered heterocycloalkyl; and \n A and E are each independently \u2014CH\u2550, or \u2014N\u2550.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 91.0
- Lexical Diversity: 1.58333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15307719', '13989611', '13997415', '14126685', '13377995']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7991951492190026
- 35 USC 102 Novelty (BERT): 0.6953940603154096
- Combined Prediction Score: 0.7888150403286434
- Mean Citation Score: 452.684838
- Max Citation Score: 705.6704
- Similarity Product: 702.1077293983459

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test