PATENT CLAIM ANALYSIS

Application Number: 15751986
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-06
Patent Classification: ["523", "111000"]

Abstract:
The invention relates to a novel cyanoacrylate medical adhesive and preparation method and application thereof, the main components of the medical adhesive is composed of alkyl cyanoacrylate and/or alkoxv cyanoacrylate and lactyl cyanoacrylate, and by adding a novel stabilizer system, the stability of the novel cyanoacrylate medical adhesive product in the invention increases substantially, the product can be stored and transported at room temperature, degradation performance of the product was greatly improved, the main technical indicators of product such as curing time and mechanical properties can meet the clinical needs, and the user experience of the product such as adhesive film flexibility is greatly improved, so the cyanoacry late medical adhesive is an widely used surgical hemostatic materials.

Claim (Index 1):
Cyanoacrylate medical adhesive, wherein the medical adhesive is prepared by raw materials comprising the following components: a cyanoacrylate composition (A); and a composite stabilizer (C);\n wherein the cyanoacrylate composition (A) comprises the following components: A 1 : a alkyl cyanoacrylate compound and/or alkoxy cyanoacrylate compound, wherein the alkyl cyanoacrylate compound comprises one or more compounds of methyl cyanoacrylate, ethyl cyanoacrylate, isobutyl cyanoacrylate, n-butyl cyanoacrylate, n-octyl cyanoacrylate, or isooctyl cyanoacrylate; the alkoxy cyanoacrylate compound comprises one or more compounds of methoxy methyl cyanoacrylate, methoxy ethyl cyanoacrylate, methoxy butyl cyanoacrylate, methoxy octyl cyanoacrylate, ethoxy methyl cyanoacrylate, ethoxy ethyl cyanoacrylate, ethoxy butyl cyanoacrylate, or ethoxy octyl cyanoacrylate; and A2: a lactyl cyanoacrylate compound, wherein the lactyl cyanoacrylate compound comprises one or more compounds of methyl lactyl cyanoacrylate, ethyl lactyl cyanoacrylate, propyl lactyl cyanoacrylate, butyl lactyl cyanoacrylate, pentyl lactyl cyanoacrylate, hexyl lactyl cyanoacrylate or isooctyl lactyl cyanoacrylate; wherein the composite stabilizer (C) comprises at least the following components: C1: an anion polymerization inhibitor, wherein the anion polymerization inhibitor comprises a strong acid substance selected from perchloric acid, permanganic acid, sulfuric acid, methanesulfonic acid, p-toluene sulfonic acid, hydrofluoric acid, sulfonic acid or their compositions; C2: a gas polymerization inhibitor, wherein the gas polymerization inhibitor is acidic gas selected from hydrogen chloride, boron trifluoride, sulfur dioxide, nitrogen dioxide or their compositions; C3: a free radical polymerization inhibitor, which comprises a quinone polymerization inhibitor with smaller steric hindrance and a quinone polymerization inhibitor with larger steric hindrance; the quinone polymerization inhibitor with smaller steric hindrance comprises one or more compounds of hydroquinone, p-hydroxyanisole and p-dimethoxybenzene; the quinone polymerization inhibitor with larger steric hindrance comprises one or more compounds of butyl hydroxyanisole (BHA), 2,6-di-tert-butyl-4-methylphenol(BHT), tert-butyl hydroquinone (TBHQ), 2,5-di-tert-butyl hydroquinone (DBHQ), p-tert-butylcatechol (TBC), 1,1-diphenyl-2- trinitrophenyl hydrazine (DPPH); C4: a natural antioxidant, wherein the natural antioxidant is selected from phytic acid, citric acid and ascorbic acid; wherein molar ratio of the alkyl cyanoacrylate compound and/or the alkoxy cyanoacrylate compound (A1) to the lactyl cyanoacrylate compound (A2) is A1:A2=10:1-1:1; amount of the anion polymerization inhibitor is 30-1000 ppm of total weight of cyanoacrylate medical adhesive, amount of the gas polymerization inhibitor is 20-500 ppm of total weight of cyanoacrylate medical adhesive, amount of the quinone polymerization inhibitor with smaller steric hindrance is 50-2000 ppm of total weight of cyanoacrylate medical adhesive, amount of the quinone polymerization inhibitor with larger steric hindrance is 50-1000 ppm of total weight of cyanoacrylate medical adhesive, amount of the natural antioxidant is 30-1000 ppm of total weight of cyanoacrylate medical adhesive.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 88.0
- Lexical Diversity: 1.78873
- Patent Class: 523.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14355827', '12214794', '12147582', '14427562', '13953011']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7564167528164274
- 35 USC 102 Novelty (BERT): 0.481315219489078
- Combined Prediction Score: 0.7289065994836925
- Mean Citation Score: 196.359176
- Max Citation Score: 213.04005
- Similarity Product: 162.3283837497175

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test