PATENT CLAIM ANALYSIS

Application Number: 15984995
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["544", "070000"]

Abstract:
The invention relates to 8-amino-2-oxo-1,3-diaza-spiro[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

Claim (Index 1):
A compound according to general formula (I) wherein R 1  and R 2  independently of one another mean \u2014H; \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014OH, \u2014OCH 3 , \u2014CN and \u2014CO 2 CH 3 ; a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014OH, \u2014OCH 3 , \u2014CN and \u2014CO 2 CH 3 ; wherein said 3-12-membered cycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted; or a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014OH, \u2014OCH 3 , \u2014CN and \u2014CO 2 CH 3 ; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted; or R 1  and R 2  together with the nitrogen atom to which they are attached form a ring and mean \u2014(CH 2 ) 3-6 \u2014; \u2014(CH 2 ) 2 \u2014O\u2014(CH 2 ) 2 \u2014; or \u2014(CH 2 ) 2 \u2014NR A \u2014(CH 2 ) 2 \u2014, wherein R A  means \u2014H or \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br and \u2014I; R 3  means \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; R 4  means \u2014H; \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said \u2014C 1 -C 6 -alkyl is optionally connected through \u2014C(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, or \u2014S(\u2550O) 2 \u2014; a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 3-12-membered cycloalkyl moiety is optionally connected through \u2014C(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014C(\u2550O)O\u2014CH 2 \u2014, or \u2014S(\u2550O) 2 \u2014; a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through \u2014C(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014C(\u2550O)O\u2014CH 2 \u2014, or \u2014S(\u2550O) 2 \u2014; a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 6-14-membered aryl moiety is optionally connected through \u2014C(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014C(\u2550O)O\u2014CH 2 \u2014, or \u2014S(\u2550O) 2 \u2014; or a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 5-14-membered heteroaryl moiety is optionally connected through \u2014C(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014C(\u2550O)O\u2014CH 2 \u2014, or \u2014S(\u2550O) 2 \u2014; R 5  means \u2014H; \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or a moiety according to general formula (X); R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , and R 20  independently of one another mean \u2014H, \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014OH, or \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein \u201cmono- or polysubstituted\u201d means that one or more hydrogen atoms are replaced by a substituent independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014R 21 , \u2014C(\u2550O)R 21 , \u2014C(\u2550O)OR 21 , \u2014C(\u2550O)NR 21 R 22 , \u2014O\u2014(CH 2 CH 2 \u2014O) 1-30 \u2014H, \u2014O\u2014(CH 2 CH 2 \u2014O) 1-30 \u2014CH 3 , \u2550O, \u2014OR 21 , \u2014OC(\u2550O)R 21 , \u2014OC(\u2550O)OR 21 , \u2014OC(\u2550O)NR 21 R 22 , \u2014NO 2 , \u2014NR 21 R 22 , \u2014NR 21 \u2014(CH 2 ) 1-6 \u2014C(\u2550O)R 22 , \u2014NR 21 \u2014(CH 2 ) 1-6 \u2014C(\u2550O)OR 22 , \u2014NR 23 \u2014(CH 2 ) 1-6 \u2014C(\u2550O)NR 21 R 22 , \u2014NR 21 C(\u2550O)R 22 , \u2014NR 21 C(\u2550O)\u2014OR 22 , \u2014NR 23 C(\u2550O)NR 21 R 22 , \u2014NR 21 S(\u2550O) 2 R 22 , \u2014SR 21 , \u2014S(\u2550O)R 21 , \u2014S(\u2550O) 2 R 21 , \u2014S(\u2550O) 2 OR 21 , and \u2014S(\u2550O) 2 NR 21 R 22 ; wherein R 21 , R 22  and R 23  independently of one another mean \u2014H; \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014OH, \u2014NH 2 , and \u2014O\u2014C 1 -C 6 -alkyl; a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014OH, \u2014NH 2 , \u2014C 1 -C 6 -alkyl and \u2014O\u2014C 1 -C 6 -alkyl; a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014OH, \u2014NH 2 , \u2014C 1 -C 6 -alkyl and \u2014O\u2014C 1 -C 6 -alkyl; a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014OH, \u2014NH 2 , \u2014C 1 -C 6 -alkyl and \u2014O\u2014C 1 -C 6 -alkyl; a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through \u2014C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014OH, \u2014NH 2 , \u2014C 1 -C 6 -alkyl and \u2014O\u2014C 1 -C 6 -alkyl; or R 21  and R 22  within \u2014C(\u2550O)NR 21 R 22 , \u2014OC(\u2550O)NR 21 R 22 , \u2014NR 21 R 22 , \u2014NR 23 \u2014(CH 2 ) 1-6 \u2014C(\u2550O)NR 21 R 22 , \u2014NR 23 C(\u2550O)NR 21 R 22 , or \u2014S(\u2550O) 2 NR 21 R 22  together with the nitrogen atom to which they are attached form a ring and mean \u2014(CH 2 ) 3-6 \u2014; \u2014(CH 2 ) 2 \u2014O\u2014(CH 2 ) 2 \u2014; or \u2014(CH 2 ) 2 \u2014NR B \u2014(CH 2 ) 2 \u2014, wherein R B  means \u2014H or \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br and \u2014I; or a physiologically acceptable salt thereof.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 93.0
- Lexical Diversity: 1.13043
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11994001', '12700857', '12699451', '15125615', '12604691']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8413014927527287
- 35 USC 102 Novelty (BERT): 0.5334486532445644
- Combined Prediction Score: 0.8105162088019123
- Mean Citation Score: 376.134266
- Max Citation Score: 388.24194
- Similarity Product: 290.2333672909427

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test