PATENT CLAIM ANALYSIS

Application Number: 16051913
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-11
Patent Classification: ["514", "230500"]

Abstract:
The present disclosure provides bicyclic heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as bromodomain inhibitors; (I), in which R 1 , R 2 , R 3 , R 4 , L 1 , L 2 , Cy 1 , Cy 2 , X, n, and dotted line have the same meaning given in the specification, and pharmaceutically acceptable salts or pharmaceutically acceptable stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders associated as bromodomain inhibitors. The present disclosure also provides preparation of compounds and pharmaceutical formulations comprising at least one of bicyclic heterocyclic derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent, or excipient.

Claim (Index 1):
A compound of formula (I): or a pharmaceutically acceptable salt or a pharmaceutically acceptable stereoisomer thereof; wherein,\n dotted line [---] represents a single bond or a double bond; \n X is O; \n L 1  is a direct bond or a linker selected from \u2014NH\u2014, \u2014NHC(O)\u2014, or \u2014NHS(O) 2 \u2014; \n L 2  is a linker selected from \u2014(CHR 6 ) n \u2014, \u2014C(O)\u2014 or \u2014S(O) 2 \u2014; \n Cy 1  is an optionally substituted 5-6 membered monocyclic ring containing 1-4 hetero atoms/-hetero groups independently selected from N, NH, O, or \u2014C(O)\u2014; wherein the optional substituent at each occurrence is independently selected from one or more R 7 ; \n Cy 2  is an optionally substituted 4-12 membered monocyclic or bicyclic ring containing 0-3 hetero atoms/hetero groups independently selected from N, NH, O, or S; wherein the optional substituent at each occurrence is independently selected from one or more Re; \n R 1  is selected from hydrogen, alkyl, alkenyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, heterocyclyl, or heterocyclylalkyl; \n R 2  and R 3  independently are hydrogen, alkyl, or together form an oxo group; \n R 4  at each occurrence is independently selected from hydrogen, alkyl, cycloalkyl, cyanoalkyl, hydroxyalkyl, or optionally substituted haloalkyl; wherein the optional substituent is one or more hydroxyl; \n R 6  is hydrogen or alkyl; \n R 7  is selected from alkyl, hydroxyl, or cycloalkyl; \n R 8  is selected from alkyl, alkoxy, amino, cyano, halogen, haloalkyl, hydroxy, \u2014C(O)alkyl, or optionally substituted heterocyclyl; wherein the optional substituent is selected from one or more alkyl or hydroxy; and \n n is an integer selected from 1 or 2.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 96.0
- Lexical Diversity: 1.90667
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15110361', '14977508', '14900139', '14134793', '14997213']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.742577604389574
- 35 USC 102 Novelty (BERT): 0.5688862626591248
- Combined Prediction Score: 0.7252084702165291
- Mean Citation Score: 381.937524
- Max Citation Score: 439.6207
- Similarity Product: 374.87497147383095

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test