PATENT CLAIM ANALYSIS

Application Number: 15954457
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "094000"]

Abstract:
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions, such as osteoarthritis.

Claim (Index 15):
A method of treating osteoarthritis, comprising: 1) fasting a human being for at least one hour, wherein the human being is suffering from osteoarthritis, followed by 2) orally administering a dosage form comprising zoledronic acid in a salt form to the human being, followed by 3) fasting the human being for at least one hour, wherein the patient is selected for having: 1) a bone marrow lesion and 2) OARSI Grade 0 or Kellgren and Lawrence Grade 0 or Grade 1 of joint space narrowing;\n wherein the dosage form has a bioavailability of zoledronic acid in a beagle dog that is improved by about 30% to about 200% as compared to zoledronic acid in the diacid form as determined by the following test:\n comparing the AUC 0-\u221e  obtained by orally administering the dosage form to a first beagle dog to the AUC 0-\u221e  obtained by orally administering a reference dosage form containing zoledronic acid in a diacid form to a second beagle dog;\n wherein the dosage form and the reference dosage form contain identical excipients with amounts of the excipients adjusted to the same molar ratio to account for the differences in molecular weights between zoledronic acid in the diacid form and zoledronic acid in the salt form; \n wherein the first beagle dog is fasted for two hours before the dosage form is administered and is fasted for two hours after the dosage form is administered; and \n wherein the second beagle dog is fasted for two hours before the reference dosage form is administered and is fasted for two hours after the reference dosage form is administered.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 91.0
- Lexical Diversity: 1.25
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15934785', '15897947', '15403073', '15697267', '15624428']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8347574676696224
- 35 USC 102 Novelty (BERT): 0.6369766582432148
- Combined Prediction Score: 0.8149793867269817
- Mean Citation Score: 667.2247199999998
- Max Citation Score: 701.7666
- Similarity Product: 575.3498916051508

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test