PATENT CLAIM ANALYSIS

Application Number: 15755475
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "046000"]

Abstract:
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Claim (Index 5):
The compound according to  claim 1 , wherein\n R 1  represents hydrogen; R 2  represents hydrogen; Y represents \u2014O\u2014 or \u2014CH 2 \u2014; Z represents \u2014X\u2014CR 5a R 5b \u2014 or \u2014CR 5e R 5g \u2014CR 5f R 5h \u2014; and when Y represents \u2014CH 2 \u2014, then Z can also represent \u2014CR 5a R 5b \u2014X\u2014; R 5a , R 5b , R 5e , R 5f , R 5g , and R 5h  represent hydrogen; X represents \u2014O\u2014; Ar represents wherein Ar is optionally substituted in the position indicated by a with a substituent selected from the group consisting of \u2014NH 2 , \u2014NH\u2014C 1-4 alkyl, and \u2014NHR 10d ; and wherein Ar is optionally substituted in the position indicated by \u03b2 with a substituent selected from the group consisting of halo and CF 3 ; provided however that Ar is substituted in at least one of the positions indicated by a or \u03b2; R 10d  represents C 3-6 cycloalkyl; C 1-4 alkyl substituted with one, two or three halo substituents; or C 1-4 alkyl substituted with one C 3-6 cycloalkyl substituent; Het represents a bicyclic aromatic heterocyclic ring system selected from the group consisting of (a-1) and (a-4); R 3a  and R 3d  each independently represent hydrogen, halo, \u2014NR 7a R 7b , C 1-4 alkyl, or \u2014O\u2014C 1-4 alkyl; R 7a  represents hydrogen; R 7b  represents hydrogen or C 1-4 alkyl; R 4a , R 4d  and R 4f  each independently represent hydrogen or halo; Q 1  represents CR 6a ; Q 2  represents CR 6b ; Q 8  represents CR 6g ; Q 9  represents CR 6h ; Q 5  represents CR 3d ; Q 6  represents N; and Q 7  represents CR 4f ; R 6a , R 6b , R 6g , and R 6h  represent hydrogen;

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 1.45652
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13207696', '16331579', '15502884', '14619371', '13983248']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7736283105351863
- 35 USC 102 Novelty (BERT): 0.5197779597816633
- Combined Prediction Score: 0.748243275459834
- Mean Citation Score: 301.543934
- Max Citation Score: 304.53442
- Similarity Product: 230.189988406992

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test