PATENT CLAIM ANALYSIS

Application Number: 16060142
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-09
Patent Classification: ["546", "082000"]

Abstract:
The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. This process may be used for the phospholipidation of toll-like receptor 7 (TLR7)-active and toll-like receptor (TLR8)-active imidazoquinolines and oxoadenines.

Claim (Index 29):
A process for preparing a compound of formula (II) comprising the steps of:\n a) reacting a compound of formula (IV) wherein n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 151, 16, 17, 18, 19, or 20; with a compound of formula (V) wherein PG is a protecting group suitable for hydroxyl protection, including but not limited to cyanoethyl, methyl, ethyl, benzyl and allyl group; to prepare a compound of formula (VI)\u2033; wherein R\u2033 is b) reacting a compound of formula (VI)\u2033 with a compound of formula (VIII) wherein d is 0, 1, 2, 3, 4, 5 or 6; Het is a four-, five-, or six membered saturated nitrogen heterocycle wherein X,Y=CH or N, and at least one of X and Y is a nitrogen atom; m is 0, 1, 2, 3, 4, 5 or 6; to prepare a compound of formula (IX)*\u2033; wherein R\u2033 is R* is c) oxidizing a compound of formula (IX)*\u2033 and removing the hydroxyl protecting group to obtain a compound of formula (II)

Metadata:
- Claim Count in Document: 29.0
- Percentile: 94.0
- Lexical Diversity: 1.775
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15781905', '14008805', '12578020', '13389307', '15126245']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.755531962944447
- 35 USC 102 Novelty (BERT): 0.5161207014787781
- Combined Prediction Score: 0.7315908367978802
- Mean Citation Score: 259.280824
- Max Citation Score: 305.36798
- Similarity Product: 198.42598463235143

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test