PATENT CLAIM ANALYSIS

Application Number: 15896309
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["424", "135100"]

Abstract:
The present invention relates to anti-IL-1 beta antibodies and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly stable. Such antibodies can be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.

Claim (Index 7):
An isolated nucleic acid molecule encoding a humanized antibody against IL-1 beta comprising variable heavy chain CDR-H1, CDR-H2 and CDR-H3 sequences as set forth in SEQ ID Nos: 4, 21, and 6, respectively, or variants thereof, and wherein\n a) position 24 of the heavy chain is an alanine residue (A); b) position 25 of the heavy chain is a phenylalanine residue (F); c) position 44 of the heavy chain is an isoleucine residue (I); d) position 56 of the heavy chain is a serine residue (S); e) position 82 of the heavy chain is a lysine residue (K); f) position 86 of the heavy chain is an arginine residue (R); and/or g) position 105 of the heavy chain is a phenylalanine residue (F); according to AHo numbering; and/or comprising variable light chain CDR-L1, CDR-L2 and CDR-L3 sequences as set forth in SEQ ID Nos: 1, 2; and 3, respectively, or variants thereof, and wherein h) position 1 of the light chain is an aspartic acid residue (D); i) position 3 of the light chain is a glutamine residue (Q); j) position 20 of the light chain is a threonine residue (T); k) position 99 of the light chain is a glutamic acid residue (E); l) position 105 of the light chain is a phenylalanine residue (F); m) position 146 of the light chain is a glutamic residue (E); n) position 147 of the light chain is an isoleucine residue (I); o) position 148 of the light chain is a lysine residue (K); and/or p) position 149 of the light chain is an arginine residue (R), according to AHo numbering.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 88.0
- Lexical Diversity: 1.24444
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14740434', '15202982', '14072165', '15127976', '11836318']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7700763557892587
- 35 USC 102 Novelty (BERT): 0.6174818259598176
- Combined Prediction Score: 0.7548169028063146
- Mean Citation Score: 431.71069400000016
- Max Citation Score: 568.2968
- Similarity Product: 521.9511785737991

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test