PATENT CLAIM ANALYSIS

Application Number: 15753328
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
The present invention relates to compositions comprising particles, each of said particles comprising a complex of at least one double-stranded polyribonucleotide, such as polyinosinic-polycytidylic acid [poly(I:C)], and at least one linear polyalkyleneimine. The particles are also characterized by their monomodal diameter distribution and z-average diameter within specific ranges. The present invention additionally relates to use of said compositions as medicaments, in particular for the treatment of a cell growth disorder characterized by abnormal growth of human or animal cells, as well as to processes for the preparation of said compositions.

Claim (Index 26):
An aqueous composition comprising one or more particles, wherein\n (a) each particle comprises a complex of at least one double-stranded polyribonucleotide, or a salt or solvate thereof, and at least one polyalkyleneimine, or a salt and/or solvate thereof, wherein\n (i) the double-stranded polyribonucleotide is polyinosinic-polycytidylic acid [poly(l:C)],\n wherein at least 60% of the double-stranded polyribonucleotides have at least 850 base pairs, at least 70% of the double-stranded polyribonucleotides have between 400 and 5000 base pairs, and between 20% and 45% of the double-stranded polyribonucleotides have between 400 and 850 base pairs; and \n \n (ii) the polyalkyleneimine comprises at least 95% linear polyethyleneimines,\n wherein the average molecular weight of the linear polyalkyleneimine is between 17 and 23 kDa and the polydispersity index is <1.5, and \n wherein the ratio of the number of moles of nitrogen of the polyalkyleneimine to the number of moles of phosphorus of the double-stranded polyribonucleotide in the composition is between 2.5 and 5.5; and \n \n (b) the particles have a z-average diameter measured according to ISO 22412 of between 30 nm and 150 nm.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 88.0
- Lexical Diversity: 1.59091
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14361827', '15465078', '13741271', '15135216', '14936375']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5531177202700037
- 35 USC 102 Novelty (BERT): 0.516886380195178
- Combined Prediction Score: 0.5494945862625211
- Mean Citation Score: 205.47544
- Max Citation Score: 239.35323
- Similarity Product: 149.85536315309287

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test