PATENT CLAIM ANALYSIS

Application Number: 15860789
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "210180"]

Abstract:
Provided herein are methods of treating a subject having a cancer, methods of selecting a treatment for a subject having a cancer, methods of selecting a subject having a cancer for a treatment that does not include a Trk inhibitor, methods of determining the likelihood that a subject having a cancer will have a positive response to a treatment with a Trk inhibitor, methods of predicting the efficacy of a Trk inhibitor in a subject having cancer, methods of determining a subject's risk for developing a Trk inhibitor-resistant cancer, and methods of determining the presence of a Trk inhibitor-resistant cancer in a subject, based on the detection of a cell from a sample from the subject that has at least one of the the point mutations in NTRK1 and/or NTRK2 and/or NTRK3.

Claim (Index 28):
The method of  claim 21 , wherein the subject was previously administered one or more doses of (S)\u2014N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate prior to being identified as having (i) at least one point mutation in a NTRK1 gene that results in the expression of a TrkA protein, (ii) at least one point mutation in a NTRK2 gene that results in the expression of a TrkB protein, and/or (iii) at least one point mutation in a NTRK3 gene that results in overexpression of a TrkC protein.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 86.0
- Lexical Diversity: 2.56364
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15785174', '15785228', '15785218', '15622388', '15861017']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8325528727121264
- 35 USC 102 Novelty (BERT): 0.734232004255003
- Combined Prediction Score: 0.8227207858664141
- Mean Citation Score: 840.608064
- Max Citation Score: 1071.22
- Similarity Product: 802.2761131227015

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test