PATENT CLAIM ANALYSIS

Application Number: 16110646
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["435", "006110"]

Abstract:
The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.

Claim (Index 1):
A method of quantifying heart transplant-derived circulating cell-free deoxyribonucleic acid in a heart transplant recipient, said method comprising:\n (a) providing circulating cell-free deoxyribonucleic acid from a biological sample from said heart transplant recipient after said heart transplant recipient has received a heart transplant from a donor, wherein said biological sample comprises blood, plasma, or serum; (b) performing one or more quantitative PCR reactions on said circulating cell-free deoxyribonucleic acid obtained from said biological sample from said heart transplant recipient, wherein said one or more quantitative PCR reactions amplify at least 10 different deoxyribonucleic acid targets, and wherein said at least 10 different deoxyribonucleic acid targets comprise at least 10 single nucleotide polymorphisms; and (c) quantifying an amount of heart transplant-derived circulating cell-free deoxyribonucleic from said heart transplant using markers distinguishable between said heart transplant recipient and said donor, wherein said markers distinguishable between said heart transplant recipient and said donor are said at least 10 single nucleotide polymorphisms.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 96.0
- Lexical Diversity: 1.17391
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16110682', '13508318', '14188455', '14536300', '15319271']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6389945542977834
- 35 USC 102 Novelty (BERT): 0.5495008006728291
- Combined Prediction Score: 0.6300451789352879
- Mean Citation Score: 336.547818
- Max Citation Score: 442.75372
- Similarity Product: 317.18202119852543

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test