PATENT CLAIM ANALYSIS

Application Number: 16002297
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "233800"]

Abstract:
The present invention provides a compound having a particular chemical structure or a pharmacologically acceptable salt thereof which has an excellent inhibitory effect on EZH1 and/or EZH2 activity. The present invention provides a compound having a 1,3-benzodioxole structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, or a pharmaceutical composition comprising the compound (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and V in the formula (I) are each as defined in the present specification).

Claim (Index 1):
A method of treating a cancer involving overexpression of enhancer of zeste homolog 2 (EZH2) or a somatic mutation in EZH2 in a subject in need thereof, comprising administering to a subject with a cancer involving overexpression of EZH2 or a somatic mutation in EZH2 a compound represented by the formula (I) or a pharmacologically acceptable salt thereof: wherein R 1  represents a hydrogen atom, a halogen atom, or a C 1 -C 6  alkyl group optionally having 1 to 3 halogen atoms, V represents a single bond, R 2  represents a hydrogen atom, a C 1 -C 6  alkyl group, or a C 3 -C 6  cycloalkyl group wherein the C 1 -C 6  alkyl group, or a C 3 -C 6  cycloalkyl group optionally has a substituent group of \u2014NR 20 R 21 , wherein R 20  and R 21  each independently represent a hydrogen atom, a formyl group, or a C 1 -C 6  alkyl group, R 3  represents a C 1 -C 6  alkyl group, R 4  represents a halogen atom or a C 1 -C 6  alkyl group optionally having 1 to 3 halogen atoms, R 5  represents a C 1 -C 6  alkyl group or a C 1 -C 6  alkoxy group, R 6  represents a C 1 -C 6  alkyl group.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 94.0
- Lexical Diversity: 1.76786
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15123523', '15742478', '14110873', '13796437', '14536162']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7831688094517492
- 35 USC 102 Novelty (BERT): 0.6274766955063823
- Combined Prediction Score: 0.7675995980572126
- Mean Citation Score: 468.236094
- Max Citation Score: 650.5967400000002
- Similarity Product: 502.4077800797797

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test