PATENT CLAIM ANALYSIS

Application Number: 16102905
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["424", "093710"]

Abstract:
The technology described herein relates, at least in part, to compositions comprising and methods for isolating and enriching natural IgM-producing phagocytic B (NIMPAB) cells and methods of producing IgM antibodies using such cells, as well as uses of the antibodies produced by the methods for the prevention and treatment of diseases wherein immunotherapy with such natural IgM antibodies and their derivatives can be useful.

Claim (Index 11):
The composition of  claim 1 , produced by a comprising the steps of\n ex vivo contacting a particle comprising a superparamagnetic iron oxide nanoparticle (SPION) with a dissociated cell sample in a container thereby forming a mixture of the particles and dissociated cells, wherein the at least one particle comprising the SPION is dispersed in poly (lactic-co-glycolic acid) (PGLA) core and the core is coated with a lipid bilayer comprising phosphatidylcholine (PtC) and polyethyleneglycol (PEG); or wherein the SPION is dispersed in aqueous solution core and the core is coated with a lipid bilayer comprising phosphatidylcholine (PtC) and polyethyleneglycol (PEG) and optionally, wherein the aqueous solution core comprises a stabilizer, for example, a catechol group modified poly (2-acrylamido-2-methyl-1-propanesulfonic acid) (pAMPS*) and wherein the pH of the aqueous solution core is neutral; or wherein the SPION is coated with citric acid and the pH of the aqueous solution core is between or at about 8 and about 9; incubating the mixture in a container to allow phagocytosis of at least one of the particles by a NIMPAB cell present in the dissociated cell sample; contacting the container with a magnet to attract at least one cell that has phagocytosed the particle to the part of the container in contact with the magnet; discarding the dissociated cells not attracted to the magnet thereby obtaining a cell sample enriched with NIMPAB cells; dissociating the magnet and the container from each other; optionally washing the cell sample enriched with NIMPAB cells; and optionally subjecting the cell sample enriched with NIMPAB cells to fluorescent activated cell sorting.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 96.0
- Lexical Diversity: 1.4
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14346330', '14256777', '13363822', '13773718', '14906663']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6794508926450471
- 35 USC 102 Novelty (BERT): 0.500885016283707
- Combined Prediction Score: 0.661594305008913
- Mean Citation Score: 221.341476
- Max Citation Score: 252.30916
- Similarity Product: 181.9309547275543

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test