PATENT CLAIM ANALYSIS

Application Number: 16399947
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["435", "006120"]

Abstract:
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.

Claim (Index 2):
A method for determining genetic mutations from an individual, comprising:\n determining whether a genetic mutation is present by analyzing a blood sample, serum sample, or plasma sample from the individual to determine a level of allelic imbalance for each of a plurality of chromosomes or chromosome segments known to exhibit cancer-associated mutations by: amplifying at least 10 polymorphic loci relating to the cancer-associated mutations from each of the plurality of chromosomes or chromosome segments of circulating tumor DNA in the blood sample, serum sample, or plasma sample from the individual to obtain amplicons, generating nucleic acid sequence data for a set of polymorphic loci on each of the plurality of chromosomes or chromosome segments by performing high throughput sequencing of the amplicons, using the nucleic acid sequence data to generate allelic data for the set of polymorphic loci on each of the plurality of chromosomes or chromosome segments, and determining the level of allelic imbalance for each of the plurality of chromosomes or chromosome segments using the allelic data, wherein a detectable allelic imbalance is indicative of a genetic mutation.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 100.0
- Lexical Diversity: 1.41463
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14918544', '16288022', '16353636', '15336630', '16399103']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6728486454450537
- 35 USC 102 Novelty (BERT): 0.6386071361229928
- Combined Prediction Score: 0.6694244945128477
- Mean Citation Score: 679.0750680000001
- Max Citation Score: 697.0339
- Similarity Product: 547.9522046334565

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test