PATENT CLAIM ANALYSIS

Application Number: 15962814
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "359000"]

Abstract:
The invention relates to compounds which are mGlu2/3 negative allosteric modulators for use in the treatment of intellectual disabilities. In another aspect, the invention relates to a pharmaceutical composition for use in the treatment of intellectual disabilities comprising a compound according to the invention and a pharmaceutically acceptable carrier.

Claim (Index 2):
A mGlu2/3 negative allosteric modulator according to  claim 1  selected from a compound of formula (I) and formula (II), wherein\n E and J are N, G is C, L is N and M is CH; \n A is selected from the group consisting of phenyl, pyridin-2-yl, pyridin-3-yl, pyridine-4-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyridazin-2-yl, pyridazin-3-yl, thiazol-2-yl, thiazol-5-yl, and thiophen-2-yl; \n B is selected from the group consisting of imidazolyl, [1,2,4]oxadiazolyl], pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl, pyrimidinyl and thiophenyl, each of which is optionally substituted by C 1-6 -alkyl; \n C is an optionally substituted aryl, wherein the substituents are selected from the group consisting of: \n ix. halo, \n x. nitro, \n xi. C 1-6 -alkyl optionally substituted by hydroxy, \n xii. NR aa R bb , wherein R aa  and R bb  are independently H, C 1-6 -alkyl or \u2014(CO)\u2014C 1-6 -alkyl, \n xiii. \u2014S\u2014C 1-6 -alkyl, \n xiv. \u2014(SO 2 )\u2014OH, \n xv. \u2014(SO 2 )\u2014C 1-6 -alkyl, \n xvi. \u2014(SO 2 )\u2014NR cc R dd , wherein R cc  and R dd  are independently: \n f. H, \n g. C 1-6 -alkyl optionally substituted by hydroxy, \n h. C 1-6 -haloalkyl, \n i. C 1-6 -alkoxy, \n j. \u2014(CO)C 1-6 -alkyl optionally substituted by C 1-6 -alkoxy, \n R 1  is CF 3 ; \n R 2  is H; \n R 3  is linear C 1-4 -alkyl substituted by one or more substituents selected from the group consisting of 1 to 6 F and 1 to 2 OH; \n R 4  is C 1-6 -alkyl; \n R 5  is C 1-6 -haloalkyl; \n R 6  is H; \n R 7  is H; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 91.0
- Lexical Diversity: 1.52941
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12053648', '13178531', '12551625', '11726575', '12394083']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7724501058052687
- 35 USC 102 Novelty (BERT): 0.5070154401611152
- Combined Prediction Score: 0.7459066392408533
- Mean Citation Score: 237.48939600000003
- Max Citation Score: 243.01498
- Similarity Product: 168.59741312790868

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test