PATENT CLAIM ANALYSIS

Application Number: 16031819
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["435", "440000"]

Abstract:
Compositions and methods for using nucleosome interacting protein domains to increase accessibility of programmable DNA modification proteins to target chromosomal sequences, thereby increasing efficiency of targeted genome/epigenetic modification in eukaryotic cells.

Claim (Index 17):
A method for increasing efficiency of targeted genome or epigenetic modification in a eukaryotic cell, the method comprising introducing into the eukaryotic cell:\n (a) at least one fusion protein or nucleic acid encoding at least one fusion protein, each fusion protein comprising a CRISPR protein linked to at least one nucleosome interacting protein domain, wherein the CRISPR protein (i) has nuclease or nickase activity or (ii) is modified to lack all nuclease activity and is linked to a non-nuclease domain; (b) at least one guide RNA or nucleic acid encoding at least one guide RNA; wherein the CRISPR protein of the at least one fusion protein is targeted to a target chromosomal sequence and the at least one nucleosome interacting protein domain of the at least one fusion protein alters nucleosomal or chromatin structure such that the at least one fusion protein has increased access to the target chromosomal sequence, thereby increasing efficiency of targeted genome or epigenetic modification.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.1
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15437148', '14105017', '15179912', '15935334', '15369533']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5675612828685559
- 35 USC 102 Novelty (BERT): 0.5353982506436877
- Combined Prediction Score: 0.5643449796460691
- Mean Citation Score: 363.518024
- Max Citation Score: 385.41925
- Similarity Product: 306.1373003263772

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test