PATENT CLAIM ANALYSIS

Application Number: 15923954
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["435", "006000"]

Abstract:
In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”).

Claim (Index 92):
A kit comprising, two or more containers comprising the following components independently distributed in one of the two or more containers:\n a) a first allele-specific primer, wherein an allele-specific nucleotide portion of the first allele-specific primer is complementary to the first allelic variant of a target sequence; and b) a first allele-specific blocker probe that is complementary to a region of the target sequence comprising the second allelic variant, wherein said region encompasses a position corresponding to the binding position of the allele-specific nucleotide portion of the first allele-specific primer, and wherein the first allele-specific blocker probe comprises a minor groove binder.

Metadata:
- Claim Count in Document: 283.0
- Percentile: 90.0
- Lexical Diversity: 1.69118
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12641321', '14445046', '14856448', '14182718', '14397405']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6527750072137326
- 35 USC 102 Novelty (BERT): 0.6156054487614951
- Combined Prediction Score: 0.6490580513685088
- Mean Citation Score: 518.833392
- Max Citation Score: 610.2238
- Similarity Product: 488.14314793984886

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test