PATENT CLAIM ANALYSIS

Application Number: 15741639
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "407000"]

Abstract:
An indole derivative as expressed by Formula (I), a preparation method thereof, a pharmaceutical salt, and use thereof as a therapeutic agent, especially as a FGFR inhibitor. Each substituent in Formula (I) has identical definition as specified in the specification.

Claim (Index 1):
A compound represented by the general formula (I) or a stereoisomer, a tautomer thereof or a pharmaceutically acceptable salt thereof: wherein: D is selected from N or CR 3 ; R 1  are each independently selected from the group consisting of hydrogen atom, alkyl, alkoxy, hydroxyl, halogen, nitro, cyano, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2014NR 4 R 5 , \u2014C(O)NR 4 R 5 , \u2014C(O)R 6 , \u2014OC(O)R 6 , \u2014C(O)OR 6  and \u2014NR 4 C(O)R 5 , wherein said alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted by one or more groups selected from the group consisting of halogen, hydroxyl, cyano, nitro, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2014NR 4 R 5 , \u2014C(O)NR 4 R 5 , \u2014C(O)R 6 , \u2014OC(O)R 6 , \u2014C(O)OR 6  and \u2014NR 4 C(O)R 5 ; R 2  are each independently selected from the group consisting of hydrogen atom, alkyl, alkoxy, hydroxyl, halogen, nitro, cyano, cycloalkyl, heterocyclyl, \u2014NR 4 R 5 , \u2014C(O)NR 4 R 5 , \u2014C(O)R 6 , \u2014OC(O)R 6 , \u2014C(O)OR 6  and \u2014NR 4 C(O)R 5 , wherein said alkyl, alkoxy, cycloalkyl or heterocyclyl is optionally further substituted by one or more groups selected from the group consisting of alkyl, halogen, hydroxyl, cyano, nitro, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2014NR 4 R 5 , \u2014C(O)NR 4 R 5 , \u2014C(O)R 6 , \u2014OC(O)R 6 , \u2014C(O)OR 6  and \u2014NR 4 C(O)R 5 ; R 3  is selected from the group consisting of cycloalkyl, cyano, \u2014NR 4 R 5 , \u2014C(O)OR 6 , \u2014OC(O)R 6 , \u2014NR 4 C(O)R 5  and \u2014C(O)NR 4 R 5 , wherein said cycloalkyl is optionally further substituted with one or more halogen; R 4 , R 5  and R 6  are each independently selected from the group consisting of hydrogen atom, alkyl, cycloalkyl, heterocyclyl, sodium ion, aryl and heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted by one or more groups selected from the group consisting of hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2014NR 7 R 8 , \u2014C(O)NR 7 R 8 , \u2014C(O)R 9 , \u2014C(O)OR 9  and \u2014NR 7 C(O)R 8 ; or, R 4  and R 5 , together with the attached N atom form a 4- to 8-membered heterocyclyl, wherein the 4- to 8-membered heterocyclic ring contains one or more atoms selected from N, O, or S(O) p , and the 4- to 8-membered heterocyclic ring is further substituted by one or more groups selected from the group consisting of hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2550O, \u2014NR 7 R 8 , \u2014C(O)NR 7 R 8 , \u2014C(O)R 9 , \u2014C(O)OR 9  and \u2014NR 7 C(O)R 8 ; R 7 , R 8  and R 9  are each independently selected from the group consisting of hydrogen atom, alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted by one or more groups selected from the group consisting of hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxyl and carboxylate; m is 0, 1, 2, 3 or 4, preferably 0, 1 or 2; n is 0, 1, 2 or 3, preferably 0, 1 or 2; and p is 0, 1 or 2.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 86.0
- Lexical Diversity: 1.47059
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15303704', '16328128', '15766692', '16302310', '14365497']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8508187147965953
- 35 USC 102 Novelty (BERT): 0.5627600847738091
- Combined Prediction Score: 0.8220128517943167
- Mean Citation Score: 436.424042
- Max Citation Score: 462.15756
- Similarity Product: 369.19726634217017

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test