PATENT CLAIM ANALYSIS

Application Number: 15768352
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["424", "450000"]

Abstract:
Irinotecan phospholipid liposomes with improved storage stability are provided, with related methods of treatment and manufacture. The irinotecan liposomes can have reduced formation of lyso-phosphatidylcholine (lyso-PC) during storage, and prior to administration to a patient.

Claim (Index 1):
A storage stabilized liposomal irinotecan composition having a pH ranging from 7.00-7.50 and comprising a dispersion of irinotecan liposomes encapsulating irinotecan sucrose octasulfate in vesicles consisting of cholesterol and the phospholipids 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and methoxy-terminated polyethylene glycol (MW 2000)-distearoylphosphatidyl ethanolamine (MPEG-2000-DSPE), at a concentration of irinotecan moiety equivalent to, in grams of irinotecan free anhydrous base, 500 mg (\u00b110%) irinotecan moiety per mmol total liposome phospholipid and 4.3 mg irinotecan moiety per mL of the liposomal irinotecan composition, the storage stabilized liposomal irinotecan composition stabilized to form less than 20 mol % Lyso-PC during the first 6 months of storage at 4\u00b0 C.

Metadata:
- Claim Count in Document: 77.0
- Percentile: 91.0
- Lexical Diversity: 1.24242
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15798287', '14395345', '15340761', '15241128', '14965140']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.726210526746421
- 35 USC 102 Novelty (BERT): 0.5544059742419862
- Combined Prediction Score: 0.7090300714959775
- Mean Citation Score: 395.737634
- Max Citation Score: 416.47427000000016
- Similarity Product: 330.70977548248896

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test