PATENT CLAIM ANALYSIS

Application Number: 15759295
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "649000"]

Abstract:
A DDS preparation of a platinum complex, which selectively releases a highly active platinum complex in cells that are under reducing conditions, and exhibits high antitumor activity that is required from a medicine, is still not available, and there is a demand for a novel DDS preparation of a platinum complex that may be used in clinical fields. There is provided a polymer conjugate of a hexa-coordinated platinum complex, the polymer conjugate comprising a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; and a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions, the hexa-coordinated platinum complex being bonded, directly or via a spacer, to a side-chain carboxyl group of the block copolymer.

Claim (Index 2):
The polymer conjugate of a hexa-coordinated platinum complex according to  claim 1 , wherein the polymer conjugate is represented by the following Formula (I): wherein R 1  represents a hydrogen atom, a (C1-C10) alkyl group which may have a substituent, or a (C6-C10) aryl group; R 2  represents a bonding group; R 3  represents a hydrogen atom or a (C1-C6) acyl group; R 4  represents a residue of a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions, or a substituent selected from the group represented by the following Formula (II): [wherein W represents a substituent selected from the group consisting of a residue of a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions, a hydroxyl group, an amino group having a benzyl group or a (C1-C10) alkyl group which may have a substituent, a (C1-C10) alkoxy group which may have a phenyl group, a (C6-C10) aryloxy group, and \u2014NR 6 CONHR 7 ; R 6  and R 7  may be identical or different, and each represents a (C3-C6) cyclic alkyl group, or a (C1-C5) alkyl group which may be substituted with a tertiary amino group; T represents a hydrogen atom, a (C1-C10) alkyl group which may have a substituent, or a (C6-C10) aryl group; and R 8  represents a (C1-C10) alkyl group which may have a substituent, a benzyl group, or a residue of an amino acid having the carboxylic acid protected], provided that at least one W among the substituents represents a residue of a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions; R 5  represents a substituent selected from the group consisting of a (C1-C30) alkoxy group, a (C1-C30) aralkyloxy group, a (C6-C10) aryloxy group, a (C1-C30) alkylamino group which may have a substituent, a di(C1-C30) alkylamino group which may have a substituent, a substituent represented by the following Formula (III) obtained by eliminating H from an \u03b1-amino group of an \u03b1-amino acid derivative: [wherein Q represents a side chain residue of an \u03b1-amino acid; T represents a hydrogen atom, a (C1-C10) alkyl group which may have a substituent, or a (C6-C10) aryl group; Z represents a substituent selected from the group consisting of an amino group having a benzyl group or a (C1-C10) alkyl group which may have a substituent, a (C1-C10) alkoxy group which may have a phenyl group, a (C6-C10) aryloxy group, and \u2014NR 12 CONHR 13 ; and R 12  and R 13  may be identical or different, and each represents a (C3-C6) cyclic alkyl group, or a (C1-C5) alkyl group which may be substituted with a tertiary amino group], and \u2014NR 9 CONHR 10 ; R 9  and R 10  may be identical or different, and each represents a (C3-C6) cyclic alkyl group, or a (C1-C5) alkyl group which may be substituted with a tertiary amino group; a represents an integer from 5 to 11,500; d, e, f, g, h, i, and j each represents an integer from 0 to 200; d+e represents an integer from 1 to 200; d+e+f+g+h+i+j represents an integer from 2 to 200; and the bonding order of the various constituent units of the polyaspartic acid is arbitrary.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 90.0
- Lexical Diversity: 1.84211
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15548259', '12312009', '13319175', '12226962', '12225230']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7896953900077616
- 35 USC 102 Novelty (BERT): 0.5152805664641058
- Combined Prediction Score: 0.762253907653396
- Mean Citation Score: 282.07612200000005
- Max Citation Score: 302.37155
- Similarity Product: 224.1969397758961

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test