PATENT CLAIM ANALYSIS

Application Number: 16249884
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["514", "561000"]

Abstract:
The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.

Claim (Index 45):
A pharmaceutical composition comprising an aqueous solution of water for injection, ibuprofen and an ibuprofen solubilizing agent selected from\n (i) tribasic sodium phosphate, tribasic potassium phosphate, or a combination of tribasic sodium phosphate and tribasic potassium phosphate, in a molar ratio of ibuprofen solubilizing agent to ibuprofen from 0.65:1 to 0.9:1; or (ii) dibasic sodium phosphate, dibasic, potassium phosphate, monobasic sodium phosphate, monobasic potassium phosphate, or a combination of any of the foregoing, together with an alkalinizing agent in an amount suitable to provide a solubilized ibuprofen solution when ibuprofen is added to the ibuprofen solubilizing agent/alkalinizing agent mixture in a ratio of ibuprofen solubilizing agent to ibuprofen from 0.8 to 1.1:1, such that the pH of the resultant aqueous ibuprofen solution is from 6.5 to 9; the aqueous solution remains clear and colorless when the ibuprofen is diluted from a concentration of 100 mg/ml to 1 mg/ml.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 99.0
- Lexical Diversity: 2.37931
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13422761', '13422738', '14538464', '13278703', '12646499']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7655338970673818
- 35 USC 102 Novelty (BERT): 0.5613345332211456
- Combined Prediction Score: 0.7451139606827581
- Mean Citation Score: 295.6457460000001
- Max Citation Score: 439.2788
- Similarity Product: 380.4934648431063

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test