PATENT CLAIM ANALYSIS

Application Number: 16054612
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-11
Patent Classification: ["424", "404000"]

Abstract:
A method of enhancing the growth of an animal is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron centre selected from amino acids or α-hydroxy acids, o-hydroxy benzoic acids or pyridine-2-carboxylic acids, such as ferric quinate, ferric tyrosine, ferric DOPA and ferric phenylalanine. Compounds which are structural and/or functional variants, derivatives and/or analogs of the foregoing compounds, as further described herein are also disclosed. Methods for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.

Claim (Index 1):
A method of treating a microbial infection in a human subject in need thereof, the method comprising administering to the subject an effective amount of one or more Fe III complex compounds, wherein the compound is in an effective disrupt preexist bacterial biofilm or reduce biofilm formation, the compound having the structure of Formula A: or a salt and/or hydrate thereof, or a functional variant thereof, wherein:\n X, X 1  and X 2  are independently NH 2 , OH, CO 2 \u2014, CO 2 H, OR 3 , NR 3 H, NR 3 R 4 , R 3 ONO 2 , R 3 NO 2 , SH, SR 3 , and X, X 1  and X 2  may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; \n Y, Y 1  and Y 2  are independently O, NH, NH 2 , NR 3 , NR 3 R 4 , SH, OR 3 , OH, and Y, Y 1  and Y 2  may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; \n Z, Z 1  and Z 2  are independently O, S, NH, NR 3 , and Z, Z 1  and Z 2  may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; \n R, R\u2032, R 1 , R 1\u2032 , R 2 , and R 2\u2032  are independently H, CH 3 , CH 2 SH, CH 2 CO 2 H, CH 2 CH 2 CO 2 H, CH 2 C 6 H 5 , CH 2 C 3 H 3 N 2 , CH(CH 3 )CH 2 CH 3 , (CH 2 ) 4 NH 2 , CH 2 CH(CH 3 ) 2 , CH 2 CH 2 SCH 3 , CH 2 CONH 2 , (CH 2 ) 4 NHCOC 4 H 5 NCH 3 , CH 2 CH 2 CH 2 , CH 2 CH 2 CONH 2 , (CH 2 ) 3 NHC(NH)NH 2 , CH 2 OH, CH(OH)CH 3 , CH 2 SeH, CH(CH 3 ) 2 , CH 2 C 8 H 6 N, CH 2 C 6 H 4 OH and R, R\u2032, R 1 , R 1\u2032 , R 2 , and R 2\u2032  may all be the same or they may all be different, or, alternatively, up to five may be the same and one or more may be different; or \n any relevant pair of R and R\u2032, R 1  and R 1\u2032 , and R 2  and R 2\u2032  (i.e. when they are bound to the same carbon atom) are linked to form a substituted or unsubstituted cycloalkyl ring group;\n R 3  and R 4  are independently be alkyl, alkenyl, alkynyl, phenyl, aryl, halo- and hydroxy-substituted radicals, hydroxyl radicals, nitrogen-substituted radicals, oxygen-substituted radicals, or hydrogen, and R 3  and R 4  may all be the same or they may all be different, or, alternatively, two may be the same and one may be different; and \n preferably the bonds between the Fe and X, X 1  and X 2  and between the Fe and Y, Y 1  and Y 2  are ionic.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 96.0
- Lexical Diversity: 1.70297
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14823340', '15874321', '15875623', '15234937', '15981794']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7598634223535427
- 35 USC 102 Novelty (BERT): 0.6118436704371044
- Combined Prediction Score: 0.7450614471618988
- Mean Citation Score: 493.72820600000006
- Max Citation Score: 640.6669999999998
- Similarity Product: 457.0347723646759

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test