PATENT CLAIM ANALYSIS

Application Number: 15865378
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["424", "009340"]

Abstract:
Provided are novel human α-synuclein-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for α-synuclein are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for α-synuclein targeted immunotherapy and diagnosis, respectively.

Claim (Index 31):
A method of treating a synucleinopathic disease in a human subject in need thereof, the method comprising administering to the human subject a therapeutically effective amount of an antibody that binds to human alph\u03b1-synuclein and comprises:\n (i) an immunoglobulin heavy chain comprising a heavy chain variable region (VH) comprising VH complementarity determining regions (CDRs) 1, 2, and 3 with the amino acid sequences set forth in residues 31-35 of SEQ ID NO:9, residues 50-68 of SEQ ID NO:9, and residues 101-102 of SEQ ID NO:9, respectively; and (ii) an immunoglobulin light chain comprising a light chain variable region (VL) comprising VL CDRs 1, 2, and 3 with the amino acid sequences set forth in residues 23-33 of SEQ ID NO:12, residues 49-55 of SEQ ID NO:12, and residues 88-98 of SEQ ID NO:12, respectively.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 86.0
- Lexical Diversity: 1.59574
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13140699', '15005948', '15410128', '14128497', '14654176']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.828343325852199
- 35 USC 102 Novelty (BERT): 0.6525474131736043
- Combined Prediction Score: 0.8107637345843396
- Mean Citation Score: 618.1686000000002
- Max Citation Score: 696.7445
- Similarity Product: 595.4539300752879

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test