PATENT CLAIM ANALYSIS

Application Number: 15751098
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "255050"]

Abstract:
Described herein are methods of treatment of stroke and traumatic brain injury comprising administration of a CRAC channel inhibitor.

Claim (Index 16):
A method for treating stroke or traumatic brain injury in an individual in need thereof comprising administering to the individual a therapeutically effective amount of a compound having the structure of Formula (II): wherein: R\u2032 1  is L 2  is \u2014NH\u2014C(\u2550O)\u2014, or \u2014C(\u2550O)NH\u2014; X is CR 3  or N; Y is independently selected from CR 9  or N; R 2  is C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, C 2 -C 8 heterocycloalkyl, C 1 -C 4 alkyleneC 2 -C 8 heterocycloalkyl, aryl, heteroaryl, fused aryl or fused heteroaryl; wherein C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, C 2 -C 8 heterocycloalkyl, C 1 -C 4 alkyleneC 2 -C 8 heterocycloalkyl, aryl, heteroaryl, fused aryl or fused heteroaryl is optionally substituted with at least one R 3 ; R 3  is independently selected from H, F, D, Cl, Br, I, \u2014CN, \u2014NO 2 , \u2014OH, \u2014CF 3 , \u2014OCF 3 , \u2014OR 5 , C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl, C 2 -C 8 heterocycloalkyl, optionally substituted aryl, optionally substituted O-aryl, optionally substituted heteroaryl, n is an integer selected from 0-2; R 9  is independently selected from H, D, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, \u2014OR 5 , \u2014OCF 3 , C 1 -C 6 carbonylalkyl, or \u2014CF 3 ; or two R 9  attached to the same carbon atom form an oxetane ring; R 10  is selected from halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, \u2014OR 5 , \u2014OCF 3 , C 1 -C 6 carbonylalkyl, or \u2014CF 3 ; R 5  is independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, phenyl, and benzyl; or a pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 88.0
- Lexical Diversity: 1.11111
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13553726', '13975238', '14730119', '12192812', '13085324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7644869175672836
- 35 USC 102 Novelty (BERT): 0.5414277773491115
- Combined Prediction Score: 0.7421810035454665
- Mean Citation Score: 369.913778
- Max Citation Score: 378.0709
- Similarity Product: 270.0277990270137

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test