PATENT CLAIM ANALYSIS

Application Number: 15950442
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "049000"]

Abstract:
Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.

Claim (Index 1):
A compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein:\n R 1  is selected from NH and N; \n the dashed line (----), in conjunction with the solid line to which it is parallel, represents an optional double bond; \n R 2  is selected from oxo or NH 2 , with the proviso that, when R 2  is oxo, R 1  is NH and the bond represented by the dashed line (----), in conjunction with the solid line to which it is parallel, is a single bond; and with the proviso that, when R 2  is NH 2 , R 1  is N and the bond represented by the dashed line (----), in conjunction with the solid line to which it is parallel, is a double bond; \n R 3  is selected from the group of H, F, CH 2 F, CHF 2 , and CF 3 ; \n R 5  is selected from the group of CN, unsubstituted C 1 -C 4  alkyl, C 1 -C 4  alkyl substituted with 1, 2, or 3 halogens, C 1 -C 4  alkyl substituted with 1 substituent selected from \u2014S\u2014CH 3  and \u2014O\u2014CH 3 , C 2 -C 4  alkenyl, C 2 -C 4  alkynyl, unsubstituted C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl substituted by 1, 2, or 3 substituents selected from F and CH 3 ; \n R 4\u2032  is selected from the group of H, \u2014C(\u2550O)R 6 , \u2014C(\u2550O)OR 6 , and \u2014C(\u2550O)NR 6 R 7 ;\n R 4  is selected from the group of H, \u2014C(\u2550O)R 6 , \u2014C(\u2550O)OR 6 , and \u2014C(\u2550O)NR 6 R 7 ; \n or\n a) R 4  is a group of the formula: \n \n \n wherein: each Y is O, S, NR,  + N(O)(R), N(OR),  + N(O)(OR), or N\u2014NR 2 ; and W 1  and W 2 , when taken together, are \u2014Y 3 (C(R) 2 ) 3 Y 3 \u2014; or one of W 1  or W 2  together with R 4\u2032  is \u2014Y 3 \u2014 and the other of W 1  or W 2  is Formula Ia; or W 1  and W 2  are each, independently, a group of the Formula Ia: wherein: each Y 1  is, independently, O, S, NR,  + N(O)(R), N(OR),  + N(O)(OR), or N\u2014NR 2 ; each Y 2  is independently a bond, O, CR 2 , \u2014O\u2014CR 2 \u2014, NR,  + N(O)(R), N(OR),  + N(O)(OR), N\u2014NR 2 , S, S\u2014S, S(O), or S(O) 2 ; each Y 3  is a single bond; M1 is 0, 1, 2, or 3; each R x  is independently R y  or the formula: wherein: each M2a, M2b, and M2c is independently 0 or 1; M2d is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12; each R y  is independently H, F, Cl, Br, I, OH, R, \u2014C(\u2550Y 1 )R, \u2014C(\u2550Y 1 )OR, \u2014C(\u2550Y 1 )N(R) 2 , \u2014N(R) 2 , \u2014 + N(R) 3 , \u2014SR, \u2014S(O)R, \u2014S(O) 2 R, \u2014S(O)(OR), \u2014S(O) 2 (OR), \u2014OC(\u2550Y 1 )R, \u2014OC(\u2550Y 1 )OR, \u2014OC(\u2550Y 1 )(N(R) 2 ), \u2014SC(\u2550Y 1 )R, \u2014SC(\u2550Y 1 )OR, \u2014SC(\u2550Y 1 )(N(R) 2 ), \u2014N(R)C(\u2550Y 1 )R, \u2014N(R)C(\u2550Y 1 )OR, \u2014N(R)C(\u2550Y 1 )N(R) 2 , \u2014SO 2 NR 2 , \u2014CN, \u2014N 3 , \u2014NO 2 , \u2014OR, or W 3 ; or when taken together, two R y  on the same carbon atom form a carbocyclic ring having 3, 4, 5, 6, or 7 carbon ring atoms; or when taken together, two R y  on the same carbon atom form along with the carbon atom a heterocycle having 3, 4, 5, 6, or 7 ring atoms wherein one ring atom is selected from O or N and all other ring atoms are carbon; each R is independently H, (C 1 -C 8 ) alkyl, (C 1 -C 8 ) substituted alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 ) substituted alkenyl, (C 2 -C 8 ) alkynyl, (C 2 -C 8 ) substituted alkynyl, C 6 -C 10  aryl, C 6 -C 10  substituted aryl, a 3- to 10-membered heterocycle, a substituted 3- to 10-membered heterocycle, a 5- to 12-membered heteroaryl, a substituted 5- to 12-membered heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, or substituted heteroarylalkyl; and W 3  is W 4  or W 5 ; W 4  is R, \u2014C(Y 1 )R y , \u2014C(Y 1 )W 5 , \u2014SO 2 R y , or \u2014SO 2 W 5 ; W 5  is selected from phenyl, naphthyl, a C 3 -C 8  carbocycle, or a 3- to 10-membered heterocycle, wherein W 5  is independently substituted with 0, 1, 2, 3, 4, 5, or 6 R y  groups; each R 6  and R 7  is independently H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 4 -C 8 )carbocyclylalkyl, C 6 -C 10  aryl, C 6 -C 10  substituted aryl, 5- to 10-membered heteroaryl, substituted 5- to 10-membered heteroaryl, \u2014C(\u2550O)(C 1 -C 8 )alkyl, \u2014S(O) n (C 1 -C 8 )alkyl or aryl(C 1 -C 8 )alkyl; or R 6  and R 7  taken together with a nitrogen to which they are both attached form a 3- to 7-membered heterocycle wherein any one ring carbon atom of said heterocycle can optionally be replaced with \u2014O\u2014, \u2014S\u2014 or \u2014NR a \u2014; and wherein each (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl or aryl(C 1 -C 8 )alkyl of each R 6  or R 7  is, independently, optionally substituted with one, two, three, or four substituents selected from halo, hydroxy, CN, N 3 , N(R a ) 2  or OR a ; and wherein one, two, or three of the non-terminal carbon atoms of each said (C 1 -C 8 )alkyl may be optionally replaced with \u2014O\u2014, \u2014S\u2014 or \u2014NR a \u2014; or\n b) R 4  is a group selected from: \n wherein:\n R 8  is selected from phenyl, 1-naphthyl, 2-naphthyl, \n R 9  is selected from H and CH 3 ; R 10  is selected from H or C 1 -C 6  alkyl; R 10\u2032  is selected from H or C 1 -C 6  alkyl; or R 10  and R 10\u2032 , together with the carbon atom to which they are bound, form a 3-, 4-, 5-, or 6-membered spirocycle wherein all ring atoms of the spirocycle are carbon; or R 10  and R 10\u2032 , together with the carbon atom to which they are bound, form a 3-, 4-, 5-, or 6-membered spirocycle wherein 1 or 2 of the ring atoms of the spirocycle are selected from the group of O, S, and N, and all other ring atoms of the spirocycle are carbon; R 11  is selected from H, C 1 -C 8  alkyl, benzyl, C 3 -C 6  cycloalkyl, \u2014CH 2 \u2014C 3 -C 6  cycloalkyl, \u2014CH 2 CH 2 \u2014S\u2014C(O)\u2014C 3 -C 6  alkyl, R 7\u2032  is selected from C 1 -C 8  alkyl, \u2014O\u2014C 1 -C 8  alkyl, benzyl, \u2014O-benzyl, \u2014CH 2 \u2014C 3 -C 6  cycloalkyl, and CF 3 ; or\n c) R 4  and R 4\u2032  combine to form the structure selected from:

Metadata:
- Claim Count in Document: 47.0
- Percentile: 91.0
- Lexical Diversity: 1.54839
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14830121', '15441561', '14806227', '15717493', '13905410']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7666180194511834
- 35 USC 102 Novelty (BERT): 0.5622244215237572
- Combined Prediction Score: 0.7461786596584408
- Mean Citation Score: 340.965214
- Max Citation Score: 411.35297
- Similarity Product: 404.12674104263016

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test