PATENT CLAIM ANALYSIS

Application Number: 15746254
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["540", "001000"]

Abstract:
Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.

Claim (Index 1):
A fused ring pyrimidine compound of formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof; wherein, P is selected from a hydrogen or a deuterium; X is selected from CH or S; Y is selected from N or CR 5 ; U is selected from a chemical bond or CH; V is selected from N or CH; W is selected from N or CR 6 ; each of R 1 , R 2 , R 3  and R 6  is independently selected from the group consisting of a hydrogen, a deuterium, a halogen, a substituted or unsubstituted alkyl, a cycloalkyl or a heterocycloalkyl; each of R 7 , R 8 , R 9 , R 10  and R 15  is independently selected from the group consisting of a hydrogen, a deuterium, a halogen, a hydroxyl, an amino, a substituted or unsubstituted alkyl, an alkoxy, or a heterocycloalkyl; R 11  is a hydrogen, a deuterium or an alkyl; or R 6 , R 2  and the two atoms on the ring to which they are attached form a \u201csubstituted or unsubstituted 5- to 7-membered carbon heterocycle\u201d; or, R 6 , R 3  and the two atoms on the ring to which they are attached form a \u201csubstituted or unsubstituted 5- to 7-membered carbon heterocycle\u201d ; the heteroatom in \u201csubstituted or unsubstituted 5- to 7-membered carbon heterocycle\u201d is selected from the group consisting of nitrogen, oxygen and sulfur;\n R 4  is a hydrogen, a deuterium, a substituted or unsubstituted alkyl, an alkoxy, a cycloalkyl, or a substituted or unsubstituted heterocycloalkyl; \n R 5  is a hydrogen, a deuterium, a halogen, or an alkyl; \n in the definitions of R 1 , R 2 , R 3  and R 6 , the \u201csubstituted\u201d in \u201ca substituted or unsubstituted alkyl\u201d means to be substituted with the substituents selected from the group consisting of a halogen, a hydroxyl, an amino, an alkyl, an alkoxy, \n and a heterocycloalkyl, in the case when multiple substituents are present, the substituents are the same or different; R 12  is a hydrogen, a deuterium, or an alkyl;\n in the definitions of R 7 , R 8 , R 9, R 10  and R 15 , the \u201csubstituted\u201d in \u201ca substituted or unsubstituted alkyl\u201d means to be substituted with the substituents selected from the group consisting of a deuterium, a halogen, a hydroxyl, an amino, an alkyl, an alkoxy, \n and a heterocycloalkyl, in the case when multiple substituents are present, the substituents are the same or different; R 13  is a hydrogen or an alkyl;\n in the definition of R 4 , the \u201csubstituted\u201d in \u201ca substituted or unsubstituted alkyl\u201d and \u201ca substituted or unsubstituted heterocycloalkyl\u201d means to be substituted with the substituents selected from the group consisting of a hydroxyl, an alkyl, \n and heterocycloalkyl, in the case when multiple substituents are present, the substituents are the same or different; R 14  is a hydrogen, an alkyl, a hydroxymethyl or an alkoxy;\n the \u201csubstituted\u201d in \u201csubstituted or unsubstituted 5- to 7-membered carbon heterocycle\u201d means to be substituted with one or more than one alkyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.83582
- Patent Class: 540.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14391386', '15025618', '15559181', '15568999', '15314938']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7743154975348129
- 35 USC 102 Novelty (BERT): 0.5277951277286536
- Combined Prediction Score: 0.749663460554197
- Mean Citation Score: 330.97676
- Max Citation Score: 348.54816
- Similarity Product: 278.2621480784797

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test