PATENT CLAIM ANALYSIS

Application Number: 15990860
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "023000"]

Abstract:
The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline, or in the form of amorphous/crystalline solid dispersions/solutions with pharmaceutically acceptable polymers and preparation process thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition.

Claim (Index 1):
A process for the preparation of SGLT-2 inhibitors represented by compound (9) comprising, reacting compound (7) with compound (8); Wherein the process for preparing compound (7) comprises: (a) reducing the compound (1) to obtain diphenylmethane compound (2); (b) coupling diphenylmethane compound (2) with the protected gluconolactone (3), followed by treatment with an acid to obtain compound (4), wherein in compound (3), PG is a hydroxyl protecting group; (c.1) treating compound (4) with a suitable reagent, wherein the hydroxy groups are protected to form compound (5), wherein PG denotes a hydroxyl protecting group; (or) (c.2) compound (4) obtained from step (b) is subjected to reduction to obtain compound 5a; (d.1) compound (5) from step (c.1) is further reacted with a reducing agent to form compound (6); (or) (d.2) compound (5a) obtained from step (c.2) is reacted with suitable reagent to protect the hydroxy groups to form compound (6). (e) subjecting compound (6) to O-demethylation in the presence of a reagent-pair, wherein R 1  is hydrogen or a hydroxyl protecting group (PG).

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.85714
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15105620', '15430409', '15571112', '15553843', '15759562']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7735499704846914
- 35 USC 102 Novelty (BERT): 0.5154651239032407
- Combined Prediction Score: 0.7477414858265463
- Mean Citation Score: 273.46067400000004
- Max Citation Score: 305.99005
- Similarity Product: 220.5207993131816

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test