PATENT CLAIM ANALYSIS

Application Number: 16216666
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["800", "006000"]

Abstract:
The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

Claim (Index 11):
The mouse of  claim 1 , said mouse being functional to form rearranged human VH, D and JH gene segments and to express mRNA transcripts encoding chimeric immunoglobulin heavy chain polypeptide comprising a human VH region and a mouse C\u03bc region, wherein said mouse comprises IgH mRNA transcripts comprising IgH-VDJC\u03bc transcripts comprising rearranged human heavy chain V, D, and J gene segments and mouse C\u03bc and encoding chimeric IgH polypeptides, wherein each IgH-VDJC\u03bc transcript encodes a human variable region comprising a CDR-H3, wherein said IgH-VDJC\u03bc transcripts comprise transcripts encoding a human variable region comprising a CDR-H3 length of 17 amino acids and transcripts encoding human variable region comprising a CDR-H3 length of 18 amino acids, wherein the mean frequency of the group consisting of said transcripts encoding CDR-H3 lengths of 17 and 18 amino acids present in said IgH-VDJC\u03bc transcripts of said mouse is between 5% and 10%.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 98.0
- Lexical Diversity: 1.61111
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15088805', '13846672', '15690183', '14935010', '13434361']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6617515455743973
- 35 USC 102 Novelty (BERT): 0.8078131446685889
- Combined Prediction Score: 0.6763577054838165
- Mean Citation Score: 877.5522199999997
- Max Citation Score: 1065.068
- Similarity Product: 1048.7783257339

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test