PATENT CLAIM ANALYSIS

Application Number: 15864494
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["424", "227100"]

Abstract:
Provided are human antibodies that specifically bind to HBV Pre-S1 domain ligand and inhibit HBV or HDV infection, antibodies binding to a set of amino acid residues that are critical for viral receptor engagement, and uses of these antibodies to prevent, or treat or diagnose HBV or HDV infection.

Claim (Index 24):
An antibody, or antigen-binding fragment thereof, comprising:\n a) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 3 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 4; b) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 7 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 8; c) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 11 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 12; d) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 15 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 16; e) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 19 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 20; f) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 23 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; g) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 27 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 28; h) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 30 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; i) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 32 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; j) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 34 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; k) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 36 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; l) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 38 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; m) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 40 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; n) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 42 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; o) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 44 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; p) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 46 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; q) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 48 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 24; r) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 38 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 50; s) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 38 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 52; t) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 38 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 54; u) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 38 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 56; or v) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 38 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO: 58.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 86.0
- Lexical Diversity: 1.47222
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15766593', '12322861', '13466439', '14449478', '15302018']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7589917916613462
- 35 USC 102 Novelty (BERT): 0.5265364447009064
- Combined Prediction Score: 0.7357462569653023
- Mean Citation Score: 341.3386900000001
- Max Citation Score: 354.49304
- Similarity Product: 273.7672431779576

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test