PATENT CLAIM ANALYSIS

Application Number: 15949736
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "653000"]

Abstract:
The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-nor epinephrine and exhibit less than 5% degradation of total norepinephrine.

Claim (Index 1):
A ready-to-inject norepinephrine composition, consisting essentially of:\n an aqueous solution comprising a chelating agent and a pharmaceutically acceptable salt; wherein the chelating agent is an aminopolycarboxylic acid present in an amount of equal or less than 100 \u03bcg/ml, and wherein the pharmaceutically acceptable salt is present in an amount of at least 0.7 wt %; norepinephrine bitartrate dissolved at a concentration of between 16 and 64 \u03bcg/ml, and wherein the norepinephrine is an R-isomer; and wherein the ready-to-administer norepinephrine composition is formulated to have a pH range of between 3.8 and 4.2 and has a composition such that after storage over at least three months equal or less than 10% of the R-isomer form will isomerize to the S-isomer and such that equal or less than 5% of the total norepinephrine will degrade to degradation products.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 91.0
- Lexical Diversity: 1.28947
- Patent Class: 514.0
- Transitional Phrase Type: half
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15883798', '14837749', '15058602', '13541524', '15663246']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.764119371625706
- 35 USC 102 Novelty (BERT): 0.5749751416177707
- Combined Prediction Score: 0.7452049486249125
- Mean Citation Score: 255.7146
- Max Citation Score: 486.84943
- Similarity Product: 358.3378087696862

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test