PATENT CLAIM ANALYSIS

Application Number: 15889800
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "006140"]

Abstract:
Methods for analyzing the bacterial microbiome of a subject and triaging the subject into treatment for head and neck squamous cell cancer from a saliva or tissue sample are provided. The methods also provide means for differentiation of different cancer patient cohorts from the bacterial microbiome of a subject.

Claim (Index 6):
A method for triaging a patient suspected of having as having Head and Neck Squamous Cell Cancer (HNSCC) into treatment comprising the steps of:\n a) obtaining a biological sample from the subject; b) isolating the nucleic acid in the sample; c) amplifying the 16S rRNA V3-V5 gene region of bacterial nucleic acid present in the sample of b) using specific primers and probes for the 16S rRNA V3-V5 region; d) sequencing the amplified DNA of step c); e) identifying the bacterial species present in the sample using high-resolution profiling of the sequences of step d); and f) triaging the subject suspected of having HNSCC into treatment for HNSCC when one or more bacterial species selected from the group consisting of  Lactobacillus gasseri, Lactobacillus johnsonii, Haemophilus parainfluenza, Lactobacillus fermentum, L. rhamnosus  and  Fusobacterium periodonticum  is present in the sample.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 88.0
- Lexical Diversity: 1.45714
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14759918', '14196999', '14270805', '14775722', '14777252']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5423106731683379
- 35 USC 102 Novelty (BERT): 0.496838177344859
- Combined Prediction Score: 0.53776342358599
- Mean Citation Score: 257.974896
- Max Citation Score: 265.53662
- Similarity Product: 206.0857035470844

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test