PATENT CLAIM ANALYSIS

Application Number: 15758274
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "233200"]

Abstract:
The present invention provides methods for inhibiting Fyn kinase, using 5-3-pyridin-2-amine, 6-3-imidazo[1,2-a] pyrazine, 6-3-imidazo[1,2-b] pyridazine, N-(5-imidazo [2,1-b][1,3,4] thiadiazol-2-yl)-amine, 4-3-1H-pyrazolo[3,4-b] pyridine, and N-(3-imidazo [1,2-b] pyridazin-6-yl) amine compounds and methods of treatment, prevention, inhibition or amelioration of diseases and conditions associated with Fyn kinase using such compounds.

Claim (Index 15):
A compound of formula (V) selected from the group consisting of 4-[4-[3-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]morpholine, 4-(3-chloro-4-fluoro-phenyl)-3-(2-methoxyphenyl)-1H-pyrazolo [3,4-b]pyridine, 3-(2-methoxyphenyl)-4-(6-methoxy-3-pyridyl)-1H-pyrazolo [3,4-b]pyridine, 3-(2-methoxyphenyl)-4-(2-methoxypyrimidin-5-yl)-1H-pyrazolo[3,4-b]pyridine, 4-[3-(3-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-N,N-dimethyl-benzamide, N,N-dimethyl-4-[3-(3-thienyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]benzamide, N-[4-(3-cyclopropyl-1H-pyrazolo [3,4-b]pyridin-4-yl)phenyl]acetamide, 3-[3-(4-pyridyl)-1H-pyrazolo[3,4-b]pyridin-4-yl] aniline, [4-[3-(3-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]methanol, 3-(2-methoxyphenyl)-4-(3-thienyl)-1H-pyrazolo[3,4-b]pyridine, N-[4-[3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]acetamide, 3-(2-methoxyphenyl)-4-[(E)-styryl]-1H-pyrazolo[3,4-b]pyridine, 4-(3-fluorophenyl)-3-(2-methoxyphenyl)-1H-pyrazolo [3,4-b]pyridine, 4-[3-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]benzamide, [4-(3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]methanol, 3-phenyl-4-(1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridine, 4-(4-isopropylphenyl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridine, 4-(3-chlorophenyl)-3-cyclopropyl-1H-pyrazolo[3,4-b]pyridine, N-(2-dimethylaminoethyl)-3-[3-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]benzamide, [3-[3-(2-methoxyphenyl)-1H-pyrazolo [3,4-b]pyridin-4-yl]phenyl]methanol, 4-[3-(3-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]benzamide, 4-[3-(4-chlorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]benzamide, 3-[3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenol, 1-[3-[3-(4-piperidyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]ethanone, N-[4-[3-(3-thienyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]acetamide, 2-methoxy-4-[3-(4-piperidyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenol, N-[3-[3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo [3,4-b]pyridin-4-yl]phenyl]methanesulfonamide, 4-(3-furyl)-3-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridine, 3-[3-(1,3-benzodioxol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenol, 4-(3-furyl)-3-(3-pyridyl)-1H-pyrazolo [3,4-b]pyridine, [4-[3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]methanol, 4-(3-methoxyphenyl)-3-(4-piperidyl)-1H-pyrazolo [3,4-b]pyridine, 4-[3-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]benzonitrile, N,N-dimethyl-4-[3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo [3,4-b]pyridin-4-yl]benzamide, [4-[3-(1,3-benzodioxol-5-yl)-1H-pyrazolo [3,4-b]pyridin-4-yl]phenyl]methanol, 4-(5-fluoro-2-methoxy-phenyl)-3-(4-piperidyl)-1H-pyrazolo[3,4-b]pyridine, 4-(4-methylsulfonylphenyl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridine, [4-[3-(3-chlorophenyl)-1H-pyrazolo [3,4-b]pyridin-4-yl]phenyl] methanol, [3-[3-(1,3-benzodioxol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]methanol, 4-(3-furyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridine, 4-(6-methoxy-3-pyridyl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo [3,4-b]pyridine, 3-cyclopropyl-4-(2-furyl)-1H-pyrazolo [3,4-b]pyridine, 4-(2-furyl)-3-(2-methoxyphenyl)-1H-pyrazolo [3,4-b]pyridine, [4-[3-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]methanol, 1-[3-[3-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]ethanone, 4-(3-furyl)-3-(4-pyridyl)-1H-pyrazolo[3,4-b]pyridine, 3-[3-(3-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]aniline, 3-(3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)benzamide, 3-[3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]aniline, and 4-(3-fluorophenyl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo [3,4-b]pyridine.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.6383
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13056331', '13057325', '12598882', '13049225', '14554714']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.830995504254442
- 35 USC 102 Novelty (BERT): 0.5335770292116883
- Combined Prediction Score: 0.8012536567501667
- Mean Citation Score: 353.30427799999984
- Max Citation Score: 374.5595
- Similarity Product: 286.9342225409448

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test