PATENT CLAIM ANALYSIS

Application Number: 16030575
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["424", "450000"]

Abstract:
The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-65 mol % of a phosphatidylcholine lipid, 30-45 mol % of cholesterol, and 2-8 mol % of a PEG-lipid; and cisplatin. Cisplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the cisplatin weight is from about 65:1 to about 95:1. Methods for the preparation of liposomal cisplatin and the treatment of cancer are also disclosed.

Claim (Index 24):
A method of treating cancer in a subject in need thereof comprising:\n administering to the subject a composition comprising:\n (a) zwitterionic liposomes consisting essentially of from about 55 mol % to about 65 mol % of a phosphatidylcholine lipid or mixture of phosphatidylcholine lipids, from about 30 mol % to about 45 mol % of cholesterol, and from about 2 mol % to about 5 mol % of a PEG-lipid; and \n (b) cisplatin, encapsulated in said liposome in an amount such that the ratio of the total lipid weight to the cisplatin weight is from about 65:1 to about 95:1; \n wherein the composition has a maximum tolerated dose greater than about 10 mg/kg and a peak DNA/platinum (Pt) adduct value greater than about 10 pg of Pt per \u03bcg of DNA.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 95.0
- Lexical Diversity: 1.67925
- Patent Class: 424.0
- Transitional Phrase Type: half
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14208297', '13664457', '15663472', '15162072', '13503614']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7945382757939726
- 35 USC 102 Novelty (BERT): 0.5814183861153858
- Combined Prediction Score: 0.7732262868261139
- Mean Citation Score: 391.876714
- Max Citation Score: 554.7429
- Similarity Product: 374.6403659062743

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test