PATENT CLAIM ANALYSIS

Application Number: 16031837
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-05
Patent Classification: ["540", "460000"]

Abstract:
Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Claim (Index 117):
A compound having the following structure, or a pharmaceutically acceptable salt, N-oxide, racemate, or stereoisomer thereof: wherein, R 1  is H or C 1 -C 6 alkyl; X 1  and X 2  are C and are members of a fused substituted 6 membered aryl ring or a fused substituted or unsubstituted 5-10 membered heteroaryl ring; R 2a  and R 2b  are independently selected from H and substituted or unsubstituted C 1 -C 6 alkyl; R 3  is C 1 -C 3 alkyl or C 1 -C 3 fluoroalkyl; R 4  is \u2014N(R 5 ) 2 , \u2014N + (R 5 ) 3 , or \u2014OR 5 ; each R 5  is independently selected from H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 1 -C 3 heteroalkyl and \u2014C 1 -C 3 alkyl-(C 3 -C 5 cycloalkyl); R 7  is selected from C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 heteroalkyl, a substituted or unsubstituted C 3 -C 10 cycloalkyl, a substituted or unsubstituted C 2 -C 10 heterocycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, \u2014C 1 -C 6 alkyl-(substituted or unsubstituted C 3 -C 10 cycloalkyl), \u2014C 1 -C 6 alkyl-(substituted or unsubstituted C 2 -C 10 heterocycloalkyl, \u2014C 1 -C 6 alkyl-(substituted or unsubstituted aryl), \u2014C 1 -C 6 alkyl-(substituted or unsubstituted heteroaryl), \u2014(CH 2 ) p \u2014CH(substituted or unsubstituted aryl) 2 , \u2014(CH 2 ) p \u2014CH(substituted or unsubstituted heteroaryl) 2 , \u2014(CH 2 ) p \u2014CH(substituted or unsubstituted aryl)(substituted or unsubstituted heteroaryl), -(substituted or unsubstituted aryl)-(substituted or unsubstituted aryl), -(substituted or unsubstituted aryl)-(substituted or unsubstituted heteroaryl), -(substituted or unsubstituted heteroaryl)-(substituted or unsubstituted aryl), or -(substituted or unsubstituted heteroaryl)-(substituted or unsubstituted heteroaryl); p is 0, 1, or 2; R 8a , R 8b , R 8c , and R 8d  are independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 1 -C 6  alkoxy, C 1 -C 6 heteroalkyl, and substituted or unsubstituted aryl; or: R 8a  and R 8d  are as defined above, and R 8b  and R 8c  together form a bond; or: R 8a  and R 8d  are as defined above, and R 8b  and R 8c  together with the atoms to which they are attached form a substituted or unsubstituted fused 5-7 membered saturated, or partially saturated carbocyclic ring or heterocyclic ring comprising 1-3 heteroatoms selected from S, O and N, a substituted or unsubstituted fused 5-10 membered aryl ring, or a substituted or unsubstituted fused 5-10 membered heteroaryl ring comprising 1-3 heteroatoms selected from S, O and N; or: R 8c  and R 8d  are as defined above, and R 8a  and R 8b  together with the atoms to which they are attached form a substituted or unsubstituted saturated, or partially saturated 3-7 membered spirocycle or heterospirocycle comprising 1-3 heteroatoms selected from S, O and N; or: R 8a  and R 8b  are as defined above, and R 8c  and R 8d  together with the atoms to which they are attached form a substituted or unsubstituted saturated, or partially saturated 3-7 membered spirocycle or heterospirocycle comprising 1-3 heteroatoms selected from S, O and N; where each substituted alkyl, heteroalkyl, fused ring, spirocycle, cycloalkyl, heterocycloalkyl, aryl or heteroaryl is substituted with 1-3 R 9 ; and each R 9  is independently selected from halogen, \u2014OH, \u2014SH, (C\u2550O), CN, C 1 -C 4 alkyl, C 1 -C 4  fluoroalkyl, C 1 -C 4  alkoxy, C 1 -C 4  fluoroalkoxy, \u2014NH 2 , \u2014NH(C 1 -C 4 alkyl), \u2014N(C 1 -C 4 alkyl) 2 , \u2014C(\u2550O)OH, \u2014C(\u2550O)NH 2 , \u2014C(\u2550O)C 1 -C 3 alkyl, \u2014S(\u2550O) 2 CH 3 , \u2014NH(C 1 -C 4 alkyl)-OH, \u2014NH(C 1 -C 4 alkyl)-O\u2014(C 1 -C 4 alkyl), \u2014O(C 1 -C 4 alkyl)-NH 2 , \u2014O(C 1 -C 4 alkyl)-NH\u2014(C 1 -C 4 alkyl), and \u2014O(C 1 -C 4 alkyl)-N\u2014(C 1 -C 4 alkyl) 2 ; or two R 9  together with the atoms to which they are attached form a methylene dioxy or ethylene dioxy ring substituted or unsubstituted with halogen, \u2014OH, or C 1 -C 3 alkyl.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 95.0
- Lexical Diversity: 1.54545
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15363935', '14648435', '15313286', '15662861', '12742425']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.744413939475669
- 35 USC 102 Novelty (BERT): 0.6016181850950988
- Combined Prediction Score: 0.730134364037612
- Mean Citation Score: 459.34824800000007
- Max Citation Score: 530.78375
- Similarity Product: 478.0374261535704

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test