PATENT CLAIM ANALYSIS

Application Number: 15879664
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["435", "007400"]

Abstract:
Disclosed are improved cell-permeable Parkin recombinant proteins (iCP-Parkin) which have been developed as a protein-based anti-neurodegenerative agent for efficient BBB-penetration to effectively deliver the recombinant protein into the brain. A Parkin protein, a dopaminergic neuronal cell death inhibitor, has been fused with a newly developed advanced macromolecule transduction domain (aMTD) and preferably with a solubilization domain (SD) to increase the solubility/yield and cell-/tissue-permeability of the recombinant protein. In addition, the aMTD/SD-fused recombinant iCP-Parkin protein has shown BBB-permeability. Both in vitro and in vivo, the iCP-Parkin recombinant protein improved motor skills, a typical phenotype of Parkinson's disease, by increasing dopamine level in the brain by suppressing apoptosis of dopaminergic neuron cells. It also can be applicable as a protein-based anti-neurodegenerative agent to treat Parkinson's disease by protecting dopaminergic neuron cells and regulating the secretion of dopamine.

Claim (Index 2):
The recombinant protein according to  claim 1 , wherein one or more solubilization domain (SD)(s) are further fused to the end(s) of one or more of the Parkin protein and the aMTD.

Metadata:
- Claim Count in Document: 34.0
- Percentile: 86.0
- Lexical Diversity: 1.77011
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15432662', '15503117', '10622817', '14424762', '09785548']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6160906104823994
- 35 USC 102 Novelty (BERT): 0.666153616502461
- Combined Prediction Score: 0.6210969110844056
- Mean Citation Score: 423.1425860000001
- Max Citation Score: 726.3612
- Similarity Product: 607.4548437139035

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test