PATENT CLAIM ANALYSIS

Application Number: 16075932
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "394000"]

Abstract:
The present invention is related to diagnostic, treatment and compound screening methods related to dry age-related macular degeneration (dry AM D). In select embodiments, the methods comprise determining expression or activity levels of NAD-dependent deacetylase sirtuin-1 (SI RT-1), AM P-activated protein kinase (AM PK), poly(adenosine diphosphate ribose) poly-merase-2 (PARP2), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-Iα) and/or mRNA levels of RAC-gamma serine/threonine-protein kinase (AKT3). In general, higher levels of PARP2, lower levels of PGC-Iα or AKT3 and/or higher acetylation levels of PGC-Iα in the samples are indicative that the subject or cells from which the samples are obtained are susceptible or are suffering from dry AMD.

Claim (Index 19):
A method of monitoring the progression of a treatment of dry age-related macular degeneration (dry AMD) in a subject, the method comprising\n a) analyzing at least two samples from a subject undergoing treatment for dry AMD with each sample taken at different time points to determine mRNA levels of RAC-gamma serine/threonine-protein kinase (AKT3) at the different time points, and b) comparing the values of the subject's mRNA levels of AKT3 over time to determine if the subject's mRNA levels of AKT3 are changing over time in response to the treatment, wherein a lack of change or a further deviation from normal mRNA levels of AKT3 in the subject's mRNA levels of AKT3 is indicative that the treatment is not effective in treating AMD in the subject, and wherein an approximation of the subject's mRNA levels of AKT3 over time towards normal mRNA levels of AKT3 is indicative that the treatment is effective in treating dry AMD in the subject.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 96.0
- Lexical Diversity: 1.71053
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12583073', '15485997', '14746221', '10773446', '11660986']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7607126345248395
- 35 USC 102 Novelty (BERT): 0.514764783019596
- Combined Prediction Score: 0.7361178493743151
- Mean Citation Score: 258.177182
- Max Citation Score: 271.42883
- Similarity Product: 164.62104335325003

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test