PATENT CLAIM ANALYSIS

Application Number: 16074579
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["424", "452000"]

Abstract:
The present invention relates to a solid unit oral dosage form comprising sacubitril and valsartan in a 1:1 molar ratio, preferably in the form of the so-called angiotensin receptor neprilysin inhibitor (ARNI) LCZ696, which is a complex salt hydrate of sacubitril, valsartan, and sodium ions, appropriate for use in pediatrics or other patients where low and individual dosing is required or who encounter problems with swallowing e.g. as a result of a disease or because of age, to the manufacture of said solid dosage form and to invention embodiments relating to therapy using said dosage form.

Claim (Index 7):
The minitablet according to  claim 1 , wherein said minitablet exhibits an in vitro dissolution profile of the active ingredient such that\u2014when measured by the USP paddle method at about 50 rpm in 900 mL of 0.05M phosphate buffer at pH 6.8 and at 37\u00b10.5\u00b0 C.\n after 10 min, an amount of about 30% (by weight) or more of valsartan and of about 25% (by weight) or more sacubitril are released, \n after 20 min, an amount of about 35% (by weight) or more of valsartan and of about 30% (by weight) or more sacubitril are released, and \n after 30 min, an amount of about 40% (by weight) or more of valsartan and of about 35% (by weight) or more sacubitril are released, \n wherein the % by weight refers to the % by weight of sacubtril and valsartan individually in relation to the weight of the total effective amount of the active ingredient sacubitril and valsartan in a 1:1 molar ratio.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 96.0
- Lexical Diversity: 1.53623
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15755733', '15568550', '16046531', '15735717', '16060297']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7031291690996163
- 35 USC 102 Novelty (BERT): 0.5220917812043246
- Combined Prediction Score: 0.6850254303100871
- Mean Citation Score: 229.49906
- Max Citation Score: 275.04184
- Similarity Product: 175.72184952170372

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test