PATENT CLAIM ANALYSIS

Application Number: 15776536
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "260100"]

Abstract:
The present invention relates to compounds of formulae I and H, or pharmaceutically acceptable salts or esters thereof. Further aspects of the invention relate to pharmaceutical compositions and therapeutic uses of said compounds in the treatment of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, inappropriate cellular inflammatory responses, or neurodegenerative disorders, preferably tauopathies, even more preferably, Alzheimer's disease.

Claim (Index 1):
A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein: R 1  is selected from:\n CO\u2014NR 12 R 13 , wherein R 12  and R 13  are each independently selected from H, alkyl, cycloalkyl and heterocycloalkyl, wherein said alkyl group is optionally substituted by one or more R 14  groups, and said heterocycloalkyl is optionally substituted by one or more R 10  groups; or R 12  and R 13  are linked, together with the nitrogen to which they are attached, to form a heterocycloalkyl group optionally containing one or more additional heteroatoms, and optionally substituted by one or more R 10  groups; \n hydroxyalkyl; \n H, \n NH 2 ; \n NH-alkyl, wherein said alkyl group is optionally substituted with one or more R 14  groups; \n NH\u2014CO-heterocycloalkyl; \n heterocycloalkyl optionally substituted by one or more R 10  groups; and \n alkoxy optionally substituted with one or more R 14  groups; \n R 2 , R 3 , R 4  and R 5  are each independently selected from H, alkyl, hydroxyalkyl and (CH 2 ) n \u2014R 12\u2032 ; or R 2  and R 3  are linked to form a cycloalkyl or heterocycloalkyl group each of which may be optionally further substituted with one or more R 10  groups; or R 4  and R 5  are linked to form a cycloalkyl or heterocycloalkyl group each of which may be optionally further substituted with one or more R 10  groups; or one of R 2  and R 3  is absent, one of R 4  and R 5  is absent, and the dashed line is a double bond; Z 1 , Z 2 , Z 3  and Z 4  are all C; R 6 , R 7 , R 8  and R 9  are each independently selected from H, CN, NO 2 , OH, alkoxy, NHCO-alkyl, halo and haloalkyl; or Z 1 , Z 3  and Z 4  are all C, Z 2  is N, R 7  is absent and R 6 , R 8  and R 9  are as defined above; or Z 2 , Z 3  and Z 4  are all C, Z 1  is N, R 6  is absent and R 7 , R 8  and R 9  are as defined above; n is an integer from 1 to 10; each R 12\u2032  is independently selected from NH 2 , NHR 10 , NR 10 R 11  and heterocycloalkyl, wherein said heterocycloalkyl is optionally further substituted by one or more R 10  groups; each R 10  and R 11  is independently alkyl; and each R 14  is independently selected from OH, alkoxy, haloalkyl, NH 2 , NHR 10 , NR 10 R 11 , heteroaryl and heterocycloalkyl, wherein said heterocycloalkyl is optionally further substituted by one or more R 10  groups.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 93.0
- Lexical Diversity: 1.45098
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15776574', '14772693', '15337184', '12784916', '15949799']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7395687408792669
- 35 USC 102 Novelty (BERT): 0.53081755642568
- Combined Prediction Score: 0.7186936224339082
- Mean Citation Score: 300.366344
- Max Citation Score: 356.07635
- Similarity Product: 317.6726188533812

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test