PATENT CLAIM ANALYSIS

Application Number: 15754163
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["544", "089000"]

Abstract:
The present invention provides compounds and methods of use thereof for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Claim (Index 2):
The method according to  claim 1 , wherein Scaffold is selected from groups of formula II: or a pharmaceutically relevant salt, wherein:\n  is the point of attachment to the amine group; \n # is the point of attachment to the carbinol group; \n each W, X, Y, or Z is independently selected from N, O, S, CU, or CH; \n k is 0, 1, 2, 3, or 4; \n each U is independently selected from halogen, cyano, \u2014R, \u2014OR, \u2014SR, \u2014N(R) 2 , \u2014N(R)C(O)R, \u2014C(O)N(R) 2 , \u2014N(R)C(O)N(R) 2 , \u2014N(R)C(O)OR, \u2014OC(O)N(R) 2 , \u2014N(R)S(O) 2 R, \u2014SO 2 N(R) 2 , \u2014C(O)R, \u2014C(O)OR, \u2014OC(O)R, \u2014S(O)R, or \u2014S(O) 2 R; \n two occurrences of U on adjacent carbon atoms can form an optionally substituted fused ring, selected from a fused phenyl ring; a fused 5-6 membered saturated or partially unsaturated heterocyclic ring containing 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or a fused 5-6 membered heteroaryl ring containing 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; and \n each R is independently selected from hydrogen, deuterium, or an optionally substituted group selected from C 1-6  aliphatic; a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring; phenyl; an 8-10 membered bicyclic aryl ring; a 3-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 6-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or a 7-10 membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 88.0
- Lexical Diversity: 1.38983
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12497103', '12339680', '15495670', '13620573', '14855299']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7562352134764375
- 35 USC 102 Novelty (BERT): 0.4898528269294815
- Combined Prediction Score: 0.7295969748217419
- Mean Citation Score: 208.574476
- Max Citation Score: 213.90195
- Similarity Product: 154.39164162118436

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test