PATENT CLAIM ANALYSIS

Application Number: 16106104
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "301000"]

Abstract:
The present invention is directed to 5-fluoro-C-(aryl or hetercyclyl)-glycoside derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity.

Claim (Index 3):
A compound as in  claim 2 , wherein\n R 1  is selected from the group consisting of \u2014C 1-2 alkyl, hydroxy substituted C 1-2 alkyl, \u2014CH 2 \u2014R 10 , hydroxy substituted C 3-6 cycloalkyl and \u2014C(O)OH; wherein R 10  is selected from the group consisting of fluoro, C 1-2 alkoxy, cyano and amino; R 2  is selected from the group consisting of hydrogen, halogen, hydroxy, C 1-2 alkyl, \u2014(C 1-4 alkyl)-OH, C 1-2 alkoxy, cyano substituted C 1-2 alkoxy, C 2-3 alkenyl-oxy-, benzyloxy- and carboxy; R 3  is selected from the group consisting of hydrogen, halogen, C 1-2 alkyl and C 2-3 alkenyl; R 4  is selected from the group consisting of hydrogen, halogen, hydroxy, C 1-2 alkyl, fluorinated C 1-2 alkyl, C 1-4 alkoxy, fluorinated C 1-2 alkoxy, cyano and C 3-6 cycloalkyl; alternatively, R 2  and R 3  or R 3  and R 4  are taken together with the carbon atoms to which they are bound to form 2,3-dihydro-furanyl; wherein the 2,3-dihydro-furanyl, is optionally substituted with one to three substituent independently selected from the group consisting of methyl, hydroxy-methyl- and hydroxy-ethyl-; R 5  and R 6  are the same and are hydrogen;  is selected from the group consisting of C 5-12 cycloalkyl, C 5-12 cycloalkenyl, phenyl, heteroaryl and heterocyclyl; wherein the phenyl is optionally substituted with one substituent independently selected from the group consisting of halogen, C 1-2 alkyl, C 1-2 alkoxy and fluorinated C 1-2 alkoxy; and wherein the heteroaryl or heterocyclyl is optionally substituted with one to two substituents independently selected from the group consisting of halogen, C 1-2 alkyl, oxo, cyano, 2,5-dimethyl-thien-3-yl, 5-methyl-thiazol-2-yl and \u2014C(O)\u2014R 11 ; wherein R 11  is selected from the group consisting of C 1-2 alkyl, C 1-2 alkoxy, C 3-6 cycloalkyl, pyrrolidin-1-yl, morpholin-4-yl and thiazol-2-yl; provided that when   is bicyclo[4.2.0]octa-1 (6),2,4-trien-3-yl or bicyclo[4.2.0]octan-3-yl, then R 2  and R 3  or R 3  and R 4  are taken together with the carbon atoms to which they are bound to form 2,3-dihydro-furanyl; wherein the 2,3-dihydro-furanyl, is optionally substituted with one to three substituent independently selected from the group consisting of methyl, hydroxy-methyl- and hydroxy-ethyl-; provided further that when   is phenyl, wherein the phenyl is optionally substituted, then R 2  and R 3  or R 3  and R 4  are taken together with the carbon atoms to which they are bound to form a ring structure selected from the group consisting of 2,3-dihydro-furanyl and tetrahydropyranyl; provided further that when   is thienyl or pyridyl, then R 2  and R 3  or R 3  and R 4  are taken together with the carbon atoms to which they are bound to form a ring structure selected from the group consisting of 2,3-dihydro-furanyl and tetrahydropyranyl; provided further that when R 1  is \u2014CH 2 OH, R 2  is H, R 3  is H, R 4  is H or Cl, R 5  is H and R 6  is H, then   is other than benzothien-2-yl; or an isotopologue or pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 96.0
- Lexical Diversity: 1.08108
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14593071', '16059072', '16059074', '13634597', '14122836']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8363528305556739
- 35 USC 102 Novelty (BERT): 0.5288767897381297
- Combined Prediction Score: 0.8056052264739195
- Mean Citation Score: 351.143048
- Max Citation Score: 357.37866
- Similarity Product: 248.2066257435036

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test