PATENT CLAIM ANALYSIS

Application Number: 15992567
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "130100"]

Abstract:
The disclosure provides methods of using biomarkers to improve diagnosis of forms of prostate. The method includes testing a biological sample from an individual for a interleukin-8 (IL-8), Tumor necrosis factor alpha (TNF-α) and soluble tumor necrosis factor-α receptor 1 (sTNFR1), and may further include testing for prostate serum antigen (PSA). Use of these markers in combination provides tests that are more sensitive and specific than PSA in differentiating benign versus malignant prostate disease and/or localized CaP versus metastatic CaP and show that the specificity and sensitivity of a PSA-based CaP diagnosis can be significantly enhanced by measuring IL-8, TNF-α and sTNFR1.

Claim (Index 3):
The kit of  claim 1  further including printed material which provides an indication that that an amount of IL8 that is equal to or greater than a reference amount, that an amount of TNFa equal to or greater than a reference amount, and that an amount of sTFNr1 equal to or greater than a reference amount, aids in a diagnosis that that the individual has the metastatic prostate disease; and/or wherein the printed material provides an indication that an amount of TNFa equal to or greater than a reference amount and an amount of sTFNr1 in an amount equal to or greater than a reference amount aids in a diagnosis that the individual has the localized prostate cancer.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 93.0
- Lexical Diversity: 1.48718
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14911580', '15304473', '13984669', '14781839', '14375535']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.672243013276799
- 35 USC 102 Novelty (BERT): 0.5275094940352919
- Combined Prediction Score: 0.6577696613526484
- Mean Citation Score: 187.773928
- Max Citation Score: 304.86002
- Similarity Product: 207.9370601013911

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test