PATENT CLAIM ANALYSIS

Application Number: 16107385
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["544", "235000"]

Abstract:
Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

Claim (Index 2):
The compound of  claim 1 , wherein the compound is of formula Ia: wherein\n R 1a  is aryl, heteroaryl or cycloalkyl, each of which is optionally substituted; \n L 1a  is \u2014C\u2261C\u2014, \u2014HC\u2550CH\u2014, \u2014CH 2 CH 2 \u2014, \u2014C(O)NH\u2014, \u2014NHC(O)\u2014, CH(OH)CH 2 \u2014, C(O)CH 2 , \n Y 1a , Y 2a  and Y 3a  are each independently CH; c, d e, and f are each independently single or double bonds; provided that when c is a double bond, d is a single bond; when d is a double bond, c and e are single bonds; when e is a double bond, d and fare single bonds; and when f is a double bond, e is a single bond; X a  is N; Q a  is NH when d and e are single bonds or N or CH when one of d or e is a double bond; Z a  is C\u2550O or CH 2 ; G a  is NR 2a  when c is a single bond, or G a  is CR 2a  when c is a double bond; R 2a  is hydrogen, lower alkyl, lower alkenyl, heteroalkyl, \u2014C(O)R 12a , \u2014CONR 12a , or cycloalkyl, each of which is optionally substituted; R 3a  is hydrogen, lower alkyl, cycloalkyl, heteroalkyl, or heterocycloalkyl, each of which is optionally substituted; or R 2a  and R 3a , together with the atoms to which they are attached are linked to form a mononcyclic or bicyclic cycloalkyl or heterocyclic ring, each of which is optionally substituted; and R 12a  is hydrogen or lower alkyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.63333
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12972293', '14299364', '14122519', '14124455', '15013741']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7912740534189361
- 35 USC 102 Novelty (BERT): 0.5703916075941919
- Combined Prediction Score: 0.7691858088364617
- Mean Citation Score: 391.818932
- Max Citation Score: 464.89075
- Similarity Product: 372.9621638797224

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test