PATENT CLAIM ANALYSIS

Application Number: 15746214
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "423000"]

Abstract:
Endogenous mechanisms leading to host protection and resolution of infections without immunosuppression are of wide interest. Here we elucidated the structures of four new host-protective molecules produced in neutrophil-endothelial co-cultures, and present in human and mouse tissues after sterile inflammation or infection. These bioactive molecules contained conjugated triene and diene double bonds with each carrying a 13-carbon position alcohol and were derived from n-3 docosapentaenoic acid (DPA, C22:5). These compounds, termed 13-series resolvins (RvT), demonstrated potent protective actions increasing mice survival during  Escherichia coli  infections. RvT also regulated human and mouse phagocyte responses stimulating bacterial phagocytosis and regulating inflammasome components. Their biosynthesis during neutrophil-endothelial cell interactions was initiated by endothelial cyclooxygenase-2 (COX-2) and increased by atorvastatin via S-nitrosylation of COX-2. The actions of atorvastatin and RvT were additive in  E. coli  infections in mice where they accelerated resolution of inflammation and increased survival >60%.

Claim (Index 14):
A method to promote phagocytosis, efferocytosis, wound healing and tissue regeneration in a subject in need thereof comprising, administering to a patient in need thereof a therapeutically effective amount of a compound according to  claim 1 .

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 1.45536
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10639714', '13007600', '11836460', '14064803', '14124761']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8015216765733385
- 35 USC 102 Novelty (BERT): 0.5381065429040773
- Combined Prediction Score: 0.7751801632064125
- Mean Citation Score: 380.788864
- Max Citation Score: 393.12112
- Similarity Product: 250.54893612552644

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test