PATENT CLAIM ANALYSIS

Application Number: 16067141
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["549", "063000"]

Abstract:
Embodiments of the present invention are directed to small molecule inhibitors of PHGDH. Other embodiments of the present invention relate to methods of treating cancers using the small molecule inhibitors of PHGDH disclosed herein. Still other embodiments of the present invention relate to methods for using the small molecule inhibitors of PHGDH to study serine metabolism.

Claim (Index 14):
A method of inhibiting 3-phosphoglycerate dehydrogenase (PHGDH) in a cellular environment comprising contacting the cellular environment with an effective amount of a compound of the formula (I): or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: R 1  is substituted or unsubstituted aryl substituted or unsubstituted arylalkyl or substituted or unsubstituted heteroaryl; R 2  is hydrogen or substituted or unsubstituted alkyl; X 1  is O or S; R 3  is \u2014NR 6 R 7  or \u2014OR 6 , wherein R 6  and R 7  are each, independently, hydrogen or substituted or unsubstituted alkyl; R 4  is substituted or unsubstituted aryl or substituted or unsubstituted alkyl; and R 5  is hydrogen, halo, \u2014C\u2261N or \u2014SR 8 , wherein R 8  is hydrogen, substituted or unsubstituted alkyl substituted or unsubstituted aryl or \u2014C\u2261N.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 94.0
- Lexical Diversity: 2.10714
- Patent Class: 549.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15705200', '15552442', '10092004', '15313012', '14965549']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6442886974923028
- 35 USC 102 Novelty (BERT): 0.5053797417163339
- Combined Prediction Score: 0.630397801914706
- Mean Citation Score: 181.898844
- Max Citation Score: 195.85783
- Similarity Product: 122.17225794348178

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test