PATENT CLAIM ANALYSIS

Application Number: 15746050
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-10
Patent Classification: ["424", "134100"]

Abstract:
The present invention relates to agents for reducing the activity of GDF15 and in particular the use of such agents to treat or prevent conditions associated with elevated or unwanted levels of GDF15. The invention is based on the discovery that GDF15 binds to the receptors CLPTM1 and QRFPR and provides agents for such use in the form of binding agents capable of binding to the receptors and inhibiting the interaction between GDF15 and the receptor. Further agents include polypeptides derived from the receptors which are capable of binding to GDF15 and inhibiting its interaction with the receptors. Also provided are diagnostic methods based on detecting the interaction or an effect thereof, and cytotoxic immune cells modified to have a reduced level and/or activity of CLPTM1.

Claim (Index 63):
A method of treating or preventing a condition associated with elevated or unwanted levels of GDF15, which method comprises administering to a subject in need thereof an effective amount of a polypeptide capable of binding to GDF15 and inhibiting its interaction with the receptors QRFPR and/or CLPTM1, wherein said polypeptide:\n (i) has or comprises an amino acid sequence as set forth in SEQ ID NO:5 (extracellular domain 3 of QRFPR), SEQ ID NO:12 (extracellular domain 4 of QRFPR) or SEQ ID NO:14 (extracellular domain of CLPTM1), or an amino acid sequence having at least 75% sequence identity to SEQ ID NO:5, 12 or 14; or (ii) is or comprises part of SEQ ID NO:5, 12 or 14, said part comprising at least 6 contiguous amino acids of SEQ ID NO:5, 12 or 14; or (iii) comprises at least 6 amino acids corresponding to at least 6 contiguous amino acids of SEQ ID NO:5, 12 or 14 and has at least 75% sequence identity to the equivalent amino acid sequence in SEQ ID NO:5, 12 or 14; and wherein said polypeptide is provided as a fusion protein comprising said polypeptide and a polypeptide sequence from a different source.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.87143
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15714015', '13078728', '15044883', '13974792', '15231309']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6670056528784389
- 35 USC 102 Novelty (BERT): 0.5289878587361947
- Combined Prediction Score: 0.6532038734642146
- Mean Citation Score: 281.044742
- Max Citation Score: 292.85443
- Similarity Product: 158.7061357665956

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test