PATENT CLAIM ANALYSIS

Application Number: 16331579
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "260100"]

Abstract:
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to fused bicyclic compounds, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MDS) and diabetes.

Claim (Index 7):
The compound according to  claim 1 , wherein\n R 1  is selected from the group consisting of CF 3 ; R 2  is selected from the group consisting of hydrogen; -L 2 -R 3  is selected from (a), (b), (c) or (d) wherein\n (a) L 2  is selected from the group consisting of >SO 2 , >CR 4a R 4b  and \u2014CHR 4a CHR 5 \u2014;\n wherein\n R 4a  is selected from the group consisting of hydrogen and C 1-4 alkyl; \n R 4b  is hydrogen; o \n R 5  is selected from the group consisting of hydrogen and C 1-4 alkyl; and \n R 3  is selected from the group consisting of Ar; Het 1 ; and Het 2 ; or \n \n \n (b) L 2  is >CR 4c R 4d ; wherein R 4c  and R 4d  are hydrogen; and\n R 3  is \n \n wherein R 12a , R 12b , and R 12c  are C 1-6 alkyl; or (c) -L 2 -R 3  is C 1-6 alkyl optionally substituted with one, two or three fluoro or \u2014OH substituents; or (d) -L 2 -R 3  is wherein\n R 13  is hydrogen; and \n R 13a  is hydrogen; \n R 13b  hydrogen; or \n R 13a  and R 13b  are bound to the same carbon atom and together form a C 3-5 cycloalkyl; \n Ar is phenyl which may be optionally substituted with one, two, or three substituents each independently selected from halo; Het 1  is a monocyclic heteroaryl selected from the group consisting of pyridyl, 4-, 5- or 6-pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, 4- or 5-thiazolyl, isothiazolyl, and isoxazolyl; each of which may be optionally substituted with one, two, or three substituents each independently selected from the group consisting of halo, \u2014CN, \u2014OR 18 , \u2014NR 19a R 19b , C 3-6 cycloalkyl, and C 1-4 alkyl optionally substituted with a substituent selected from the group consisting of \u2014OR 20 , and \u2014NR 21a R 21b ; and Het 2  is a non-aromatic heterocyclyl optionally substituted with one, two, or three substituents each independently selected from the group consisting of halo, \u2014OR 18 , \u2014C(\u2550O)\u2014O\u2014C 1-6 alkyl, \u2014C(\u2550O)\u2014Ar 2 , \u2014C(\u2550O)\u2014Het 3 , and \u2014C(\u2550O)\u2014Het 4 ; Ar 2  is phenyl; Het 3  is pyridyl; Het 4  is oxetanyl, or tetrahydropyranyl; wherein R 18 , R 20 , R 21a  and R 21b  are each independently selected from the group consisting of hydrogen; and C 1-4 alkyl.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 99.0
- Lexical Diversity: 1.34146
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15766887', '15537619', '15976037', '15537551', '15976223']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7907559540029614
- 35 USC 102 Novelty (BERT): 0.5200107735161567
- Combined Prediction Score: 0.763681435954281
- Mean Citation Score: 294.28313799999995
- Max Citation Score: 308.84235
- Similarity Product: 238.493195031032

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test