PATENT CLAIM ANALYSIS

Application Number: 15977258
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["506", "002000"]

Abstract:
Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject. TCR and/or IG sequence diversity and sequence distribution permit immunocompetence and immune repertoire assessment and reflect the degree of T cell or B cell clonality and clonal expansion in the sample. Methods for stratifying patient populations on the basis of immunocompetence including likelihood of responding to immunotherapy are also described.

Claim (Index 7):
The method of  claim 1 , wherein quantifying an AIR sequence distribution score comprises:\n determining a number of unique rearranged AIR nucleic acid sequences that account for combined frequency of occurrence of up to 50%, 40%, 30%, 20% or 10% of the total number of observed rearranged sequences in said sample; and characterizing said AIR sequence distribution score as a low score if the number of unique rearranged AIR nucleic acid sequences that have said combined frequency of occurrence of the total number of observed rearranged sequences in said sample is less than or equal to a predetermined threshold.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 93.0
- Lexical Diversity: 1.50725
- Patent Class: 506.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15637871', '13708847', '14199167', '13656265', '14471821']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5038555326973418
- 35 USC 102 Novelty (BERT): 0.6082717781090282
- Combined Prediction Score: 0.5142971572385105
- Mean Citation Score: 395.108366
- Max Citation Score: 693.2953
- Similarity Product: 444.4091281773627

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test