PATENT CLAIM ANALYSIS

Application Number: 15997643
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["435", "456000"]

Abstract:
The present invention provides methods and compositions for improving the efficacy of viral transduction of cells. More particularly, the present invention provides methods and materials useful for safely and reliably improving the efficiency of methods for transducing cells, such as human hematopoietic stern cells (HSC), with viruses and/or viral vectors. The compositions and methods are useful for therapeutic indications amenable to treatment with hematopoietic stem cell gene therapies.

Claim (Index 53):
The method of  claim 46 , wherein the lentivirus comprises: a) a left (5\u2032) HIV-1 LTR comprising a CMV promoter; b) a Psi (\u03a8+) packaging signal; c) a cPPT/FLAP; d) an RRE; e) an MND promoter, operably linked to a polynucleotide encoding a human ABCD1 polypeptide; f) a right (3\u2032) HIV-1 SIN LTR; and g) a r\u03b2gpA sequence.

Metadata:
- Claim Count in Document: 86.0
- Percentile: 94.0
- Lexical Diversity: 1.61702
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14348572', '13242815', '14125220', '14700021', '14488058']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6519776190654325
- 35 USC 102 Novelty (BERT): 0.6476684344652611
- Combined Prediction Score: 0.6515467006054154
- Mean Citation Score: 465.721416
- Max Citation Score: 657.55383
- Similarity Product: 590.52457190629

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test