PATENT CLAIM ANALYSIS

Application Number: 15765736
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-03
Patent Classification: ["514", "04400A"]

Abstract:
The application discloses compositions and methods for preventing and treating diabetic retinopathy. It is disclosed herein that an inhibitor of microRNA-let-7b administered to the eye of a subject in need thereof is useful for preventing and treating several problems associated with diabetic retinopathy and plays a role in vasculature stabilization, increasing retinal thickness, reducing retinal capillary dropout, diminishing microvascular leakage, preventing or treating hyperproliferation of microvascular cells, and stabilizing aberrant neovascularization. The invention includes the use of various kinds of inhibitors of microRNA-let-7b, including, but not limited to, an antagomir of miRNA-let-7b. A useful compound of the invention can be administered into the eye, including intravitreally. A useful antagomir is Dy547-mA(*)mA(*)mCmCmAmCmAmCmAmAmCmCmUmAmCmUmAmCmCmU(*) mC(*)mA (*)(3′-Chl).

Claim (Index 16):
The method of  claim 12 , wherein said nucleic acid comprises an LNA at each nucleotide residue.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 91.0
- Lexical Diversity: 1.81481
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12936732', '12437899', '14342867', '15335271', '14704458']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7210975024121467
- 35 USC 102 Novelty (BERT): 0.5109586921277379
- Combined Prediction Score: 0.7000836213837057
- Mean Citation Score: 243.96270400000003
- Max Citation Score: 276.13083
- Similarity Product: 196.51762712298628

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test