PATENT CLAIM ANALYSIS

Application Number: 15763366
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "518000"]

Abstract:
Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Claim (Index 12):
The method of  claim 10 , wherein said cancer is a solid tumor cancer selected from the group consisting of: Oral cancer selected from the group consisting of buccal cavity, lip, tongue, mouth, and pharynx cancer; Cardiac cancer selected from the group consisting of sarcoma, myxoma, rhabdomyoma, fibroma, lipoma, and teratoma; Lung cancer selected from the group consisting of bronchogenic carcinoma, alveolar carcinoma, bronchial adenoma, sarcoma, lymphoma, chondromatous hamartoma, and mesothelioma; Gastrointestinal cancer selected from the group consisting of esophagus, stomach, pancreas, small bowel or small intestines, large bowel or large intestines, colon, colon-rectum, colorectal, and rectum; Genitourinary tract cancer selected from the group consisting of kidney, bladder and urethra, prostate, and testis cancer; Liver cancer selected from the group consisting of hepatoma, cholangiocarcinoma, hepatoblastoma, angiosarcoma, hepatocellular adenoma, hemangioma, and biliary passages cancer; Bone cancer selected from the group consisting of osteogenic sarcoma, fibrosarcoma, malignant fibrous histiocytoma, chondrosarcoma, Ewing's sarcoma, malignant lymphoma, multiple myeloma, malignant giant cell tumor chordoma, osteochronfroma, benign chondroma, chondroblastoma, chondromyxofibroma, and osteoid osteoma and giant cell tumors; Nervous system cancer selected from the group consisting of skull, meninges, and brain; Gynecological cancer selected from the group consisting of uterus, cervix, ovaries, vulva, vagina, and breast; Skin cancer selected from the group consisting of malignant melanoma, basal cell carcinoma, squamous cell carcinoma, Karposi's sarcoma, keratoacanthoma, moles dysplastic nevi, lipoma, angioma, and dermatofibroma; Thyroid gland cancer selected from the group consisting of papillary thyroid carcinoma, follicular thyroid carcinoma; medullary thyroid carcinoma, multiple endocrine neoplasia type 2A, multiple endocrine neoplasia type 2B, familial medullary thyroid cancer, pheochromocytoma, and paraganglioma; Adenoid cystic carcinoma; and Adrenal gland cancer.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 90.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15031426', '15665506', '12988755', '14596052', '15081076']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8082359349134497
- 35 USC 102 Novelty (BERT): 0.5254474485444673
- Combined Prediction Score: 0.7799570862765515
- Mean Citation Score: 311.3153240000001
- Max Citation Score: 332.41208
- Similarity Product: 207.0334926205444

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test