PATENT CLAIM ANALYSIS

Application Number: 15745461
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["548", "255000"]

Abstract:
The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those routes.

Claim (Index 18):
The method of  claim 17 , wherein:\n the 4-bromopyridine or the salt thereof is 4-bromopyridine hydrochloride; the zinc or copper catalyst is ZnBr 2  or CuI; the palladium catalyst is selected from the group consisting of:\n PdCl 2  \n Pd(OAc) 2 , \n Pd(PPh 3 ) 4 , \n Pd(PPh 3 ) 2 Cl 2 , \n [1,2-bis(diphenylphosphino)ethane]-dichloropalladium(II), \n (1,3-bis(diphenylphosphino)propane)palladium(II) chloride, and \n [1,1\u2032-bis(diphenylphosphino)ferrocene]dichloropalladium(II); \n the base is selected from the group consisting of:\n CsCO 3  \n K 2 CO 3 , \n Na 2 CO 3 , and \n an amine; and \n the solvent is selected from the group consisting of:\n N,N-dimethylformamide, \n N,N-dimethylacetamide, \n tetrahydrofuran, \n diisopropyl ether, \n toluene, \n anisole, \n t-butylmethyl ether, \n diethyl ether, \n 1,4-dioxane, \n 1,2-dimethoxyethane, \n N-methylpyrrolidone, and \n dimethylsulfoxide.

Metadata:
- Claim Count in Document: 108.0
- Percentile: 86.0
- Lexical Diversity: 1.125
- Patent Class: 548.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14853883', '14946137', '15355630', '15841828', '13889980']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7272610029377364
- 35 USC 102 Novelty (BERT): 0.4968488976789462
- Combined Prediction Score: 0.7042197924118575
- Mean Citation Score: 216.948504
- Max Citation Score: 220.2003
- Similarity Product: 157.2910510560751

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test