PATENT CLAIM ANALYSIS

Application Number: 16094243
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["544", "297000"]

Abstract:
The present invention relates to new polymorphic forms of Crystalline Rosuvastatin calcium along with novel processes for crystalline as well as amorphous Rosuvastatin calcium.

Claim (Index 4):
A novel process for the preparation of highly pure crystalline form \u2018M\u2019 of the compound 7-[4-(4-flurophenyl)-6-isopropyl-2-(N-methyl-N-methyl sulfonyl amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid Calcium salt or hydrates thereof according to  claim 1 , which comprises\n i. Deprotection of tert-butyl-2-((4R,6S)-6-((E)-2-(4(-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulphonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate in acetonitrile using dilute hydrochloric acid \n ii. Hydrolysis of resulting material with aq. Caustic solution. \n iii. Complete removal of acetonitrile from reaction mass under vacuum. \n iv. Addition of water & methyl tert-butyl ether. \n v. Layer separation \n vi. Isolation of Rosuvastatin calcium by addition of calcium chloride to aq. layer. \n vii. Recrystallization of resulting Rosuvastatin Calcium (wet or dry) using an aliphatic ketone such as acetone, ethyl methyl ketone, diethyl ketone, dipropyl ketone, dibutyl ketone or a mixture thereof & water. \n viii. Isolation of novel Rosuvastatin calcium crystalline form M by routine filtration & drying.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 97.0
- Lexical Diversity: 1.13636
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13885509', '12449426', '13574005', '14901721', '13143943']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8272218719257511
- 35 USC 102 Novelty (BERT): 0.5480632642560753
- Combined Prediction Score: 0.7993060111587836
- Mean Citation Score: 386.299474
- Max Citation Score: 421.883
- Similarity Product: 335.83526492285733

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test