PATENT CLAIM ANALYSIS

Application Number: 15956133
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-04
Patent Classification: ["514", "017700"]

Abstract:
Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

Claim (Index 58):
The method of  claim 1 , wherein the necrosis inhibitor is a compound of Formula IX: or a pharmaceutically acceptable salt, an ester, or a prodrug thereof, wherein:\n X 1  and X 2  are, independently, N or CR 4 ; \n X 3  is selected from O, S, NR 5 , or (CR 5 ) 2 ; \n Y is selected from C(O) or CH 2 ; and \n Z is (CR 6 R 7 ) n ; \n R 1  is selected from H, halogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 cycloalkyl, or optionally substituted aryl; \n R 2  is selected from H or optionally substituted C 1 -C 6 alkyl; \n R 3  is optionally substituted aryl; \n each R 4  is selected from H, halogen, carboxamido, nitro, cyano, optionally substituted C 1 -C 6 alkyl, or optionally substituted aryl; \n R 5  is selected from H, halogen, optionally substituted C 1 -C 6 alkyl, or optionally substituted aryl; \n each R 6  and R 7  is, independently, selected from H, optionally substituted C 1 -C 6 alkyl, or aryl; and \n n is 0, 1, 2, or 3.

Metadata:
- Claim Count in Document: 73.0
- Percentile: 91.0
- Lexical Diversity: 1.66102
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15093480', '15288214', '14934810', '12086792', '15100967']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.780259566048307
- 35 USC 102 Novelty (BERT): 0.7388797339441677
- Combined Prediction Score: 0.7761215828378931
- Mean Citation Score: 535.4984059999998
- Max Citation Score: 823.15753
- Similarity Product: 802.1986106013492

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test