PATENT CLAIM ANALYSIS

Application Number: 16005170
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["435", "007100"]

Abstract:
Combining presynaptic proteins, neuronal pentraxin 2 (NPTX2) and neurexin 2α (NRXN2α), with respective postsynaptic functional partners GluA4-containing glutamate receptor (AMPA4) and neuroligin 1 (NLGN1), and enhancing excitatory synaptic activities in areas of the hippocampus and cerebral cortex. As early damage of such excitatory circuits in Alzheimer's disease (AD) correlates with cognitive losses, plasma neuron-derived exosome (NDE) levels of these two pairs of synaptic proteins are quantified and serve as biomarkers. NDE contents of all four proteins decrease significantly in AD dementia and diminished levels of AMPA4 and NLGN1 correlate with the extent of cognitive losses. Prior to the onset of dementia, NDE levels of all but NPTX2 are significantly lower than those of matched control subjects and levels of all decline significantly with the development of dementia. Reductions in NDE levels of these excitatory synaptic proteins are indicators of cognitive losses and reflect progression of severity of AD.

Claim (Index 1):
Combined quantification of plasma neuron-derived exosome (NDE) levels of four synaptic proteins of excitatory central nervous system (CNS) pathways to determine risk of development of Alzheimer's disease (AD) and/or determine progression of cognitive loss, wherein said four synaptic proteins are\n (a) presynaptic proteins neuronal pentraxin 2 (NPTX2) and neurexin 2\u03b1 (NRXN2\u03b1), and (b) postsynaptic GluA4-containing glutamate receptor (AMPA4) and neuroligin 1 (NLGN1), and wherein said NDE levels for each synaptic pair of (i) said NPTX2 and said AMPA4 and (ii) said NRXN2\u03b1 and said NLGN1, serve as an indicator of onset of AD, and of progression of cognitive functional losses.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 1.92135
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15600959', '15511860', '13185831', '14112765', '12727359']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6098095515928617
- 35 USC 102 Novelty (BERT): 0.5199895733290355
- Combined Prediction Score: 0.6008275537664791
- Mean Citation Score: 239.751736
- Max Citation Score: 319.6038200000001
- Similarity Product: 221.8087104842425

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test