PATENT CLAIM ANALYSIS

Application Number: 16300162
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["514", "210200"]

Abstract:
The present invention provides a 2,4,6-trisubstituted s-triazine compound represented by general formula (I) or pharmaceutically acceptable salts, prodrugs or solvates thereof, a preparation method therefor, and use of these compounds in preparing drugs for preventing or treating diseases associated with protein kinase and vimentin dysregulation, and cell vacuolization, and in particular, drugs for treating or preventing cancer growth and metastasis, tissue fibrosis and atherosclerosis.

Claim (Index 1):
A compound represented by general Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein:\n R 1  is hydrogen, halogen, nitro, amino, hydroxyl, C 1 -C 12  alkyl, C 1 -C 6  alkoxyl, C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, hydroxymethyl, or aminomethyl; \n R 2  is \u2014NR 4 R 5 , wherein R 4  and R 5  are independently selected from a group consisting of hydrogen, C 1 -C 6  alkyl and C 1 -C 6  haloalkyl; or R 4 , R 5  and the nitrogen atom bonded to them form a saturated or unsaturated 4 to 6-member heterocyclic ring containing optionally an additional heteroatom selected from a group consisting of NR 6 , O and S, wherein the heterocyclic ring is optionally substituted with hydroxyl, halogen, nitro, amino or C 1 -C 6  alkyl, wherein R 6  is hydrogen, hydroxyl, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; \n R 3  is hydrogen, halogen, nitro, amino, hydroxyl, C 1 -C 12  alkyl, C 1 -C 6  alkoxyl, C 1 -C 6  alkylamino, di-C 1 -C 6  alkylamino, hydroxymethyl, aminomethyl or \u2014COR a ; \n R a  is OH or NR 7 R 8 , wherein R 7  and R 8  are independently selected from a group consisting of hydrogen, C 1 -C 6  alkyl optionally substituted with one or more substituents selected from halogen or NR 9 R 10 , and C 1 -C 6  alkyl substituted with 3-(C 2 -C 6  alkynyl)-3H-diaziridinyl; or R 7 , R 8  and the nitrogen atom bonded to them form a 4 to 6-member heterocyclic ring containing optionally an additional heteroatom selected from a group consisting of N, O and S, and optionally substituted with C 1 -C 6  alkyl; \n R 9  and R 10  are independently selected from a group consisting of hydrogen and C 1 -C 6  alkyl; or R 9 , R 10  and the nitrogen atom bonded to them form a 4 to 6-member heterocyclic ring containing optionally an additional heteroatom selected from a group consisting of N, O and S; and \n X is NH or O, linked to the phenyl group on a para- or meta-position.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 98.0
- Lexical Diversity: 1.37037
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15752896', '15533048', '14369559', '10763105', '15128471']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8101049070386874
- 35 USC 102 Novelty (BERT): 0.5273025832759677
- Combined Prediction Score: 0.7818246746624156
- Mean Citation Score: 329.125342
- Max Citation Score: 335.1889
- Similarity Product: 259.1581997087597

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test