PATENT CLAIM ANALYSIS

Application Number: 15903928
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "601000"]

Abstract:
The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Claim (Index 8):
A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:\n 4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 8-chloro-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1R)-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 1-benzyl-4-chloro-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-methoxy-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 1-benzyl-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 1-ethyl-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1R)-8-chloro-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1S)-8-chloro-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-N-(2,2-difluoro-2H-1,3-benzodioxole-4-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 7-chloro-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 8-bromo-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-1-[2-(3,3-difluoropyrrolidin-1-yl)ethyl]-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4-chloro-1-ethyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-chloro-1-ethyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (6S)-6-methyl-N-(naphthalene-1-sulfonyl)-7,8-dihydro-2H,6H-indeno[4,5-d][1,3]dioxole-6-carboxamide; (6R)-6-methyl-N-(naphthalene-1-sulfonyl)-7,8-dihydro-2H,6H-indeno[4,5-d][1,3]dioxole-6-carboxamide; (1S)-6-methoxy-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-6-methoxy-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(naphthalene-1-sulfonyl)-6,7,8,9-tetrahydro-2H-naphtho[1,2-d][1,3]dioxole-6-carboxamide; (1S)-7-chloro-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-7-chloro-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-1-ethyl-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-(cyclopropylmethyl)-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 1-butyl-4-chloro-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(8-hydroxynaphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 8-bromo-5-ethoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-cyclobutyl-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-chloro-1-ethyl-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-N-(naphthalene-1-sulfonyl)-1-[6-(trifluoromethyl)pyridin-2-yl]methyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-[(6-chloropyridin-3-yl)methyl]-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-[(6-methoxypyridin-2-yl)methyl]-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(5-chloronaphthalene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 8-bromo-N-(naphthalene-1-sulfonyl)-5-[(propan-2-yl)oxy]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-bromo-8-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-1-ethyl-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(1-benzothiophene-4-sulfonyl)-4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 8-bromo-5-(2-methoxyethoxy)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1S)-4-bromo-7-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-bromo-7-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-8-bromo-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1R)-8-bromo-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-bromo-8-methoxy-N-(quinoline-5-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1S)-4-bromo-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-bromo-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-ethoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-N-(naphthalene-1-sulfonyl)-7-[(propan-2-yl)oxy]-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-(cyclopropylmethoxy)-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 8-bromo-5-methoxy-N-(quinoline-5-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-methoxy-8-(4-methylphenyl)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-bromo-7-(difluoromethoxy)-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-8-cyclobutyl-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1R)-8-cyclobutyl-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1S)-5-bromo-8-methoxy-N-(quinoline-5-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1R)-5-bromo-8-methoxy-N-(quinoline-5-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1S)-8-chloro-1-ethyl-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1R)-8-chloro-1-ethyl-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-1-ethyl-N-(1-methyl-1H-indole-7-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 5-methoxy-8-(2-methylpropyl)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-methoxy-5-(2-methylpropyl)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-cyclobutyl-8-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-chloro-8-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1S)-4-chloro-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-chloro-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 5,8-dimethoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-1-ethyl-N-(1-methyl-1H-indole-4-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 7-methoxy-4-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-cyclobutyl-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-cyclobutyl-7-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-N-(imidazo[1,2-a]pyridine-5-sulfonyl)-7-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 2-bromo-5-methoxy-N-(naphthalene-1-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (1S)-4-cyclobutyl-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-cyclobutyl-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 8-cyclobutyl-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 7-cyclobutyl-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-7-bromo-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-7-bromo-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-7-chloro-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-7-chloro-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 5-cyclopropyl-8-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1S)-4,7-dimethoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4,7-dimethoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4,7-dimethoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4,7-dimethoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-7-methoxy-N-(naphthalene-1-sulfonyl)-4-(trifluoromethyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-7-methoxy-N-(naphthalene-1-sulfonyl)-4-(trifluoromethyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-7-methoxy-N-(quinoline-5-sulfonyl)-4-(trifluoromethyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-7-methoxy-N-(quinoline-5-sulfonyl)-4-(trifluoromethyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(1-methyl-1H-indazole-7-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-cyclobutyl-7-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-methoxy-N-(3-methylimidazo[1,2-a]pyridine-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-methoxy-N-(2-methylimidazo[1,2-a]pyridine-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 2-cyclobutyl-5-methoxy-N-(naphthalene-1-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (1R)-4-cyclobutyl-7-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4-cyclobutyl-7-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-N-(5-hydroxynaphthalene-1-sulfonyl)-7-methoxy-2,3-dihydro-1H-indene-1-carboxamide; (7S)-2-cyclobutyl-5-methoxy-N-(naphthalene-1-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (7R)-2-cyclobutyl-5-methoxy-N-(naphthalene-1-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (1R)-4-methoxy-7-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4-methoxy-7-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-1-methoxy-N-(naphthalene-1-sulfonyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-7-carboxamide; 4-cyclobutyl-1-methoxy-N-(naphthalene-1-sulfonyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-7-carboxamide; 4-chloro-1-methoxy-N-(naphthalene-1-sulfonyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-7-carboxamide; 4-bromo-1-methoxy-N-(naphthalene-1-sulfonyl)-5,6,7,8-tetrahydroisoquinoline-8-carboxamide; 2-cyclobutyl-5-methoxy-N-(quinoline-5-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (8S)-4-bromo-1-methoxy-N-(naphthalene-1-sulfonyl)-5,6,7,8-tetrahydroisoquinoline-8-carboxamide; (8R)-4-bromo-1-methoxy-N-(naphthalene-1-sulfonyl)-5,6,7,8-tetrahydroisoquinoline-8-carboxamide; (1S)-7-methoxy-N-(2-methylquinoline-5-sulfonyl)-4-(trifluoromethyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-7-methoxy-N-(2-methylquinoline-5-sulfonyl)-4-(trifluoromethyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-cyclobutyl-7-methoxy-N-(1,2,3,4-tetrahydroquinoline-8-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (8R)-4-cyclobutyl-1-methoxy-N-(naphthalene-1-sulfonyl)-5,6,7,8-tetrahydroisoquinoline-8-carboxamide; (8S)-4-cyclobutyl-1-methoxy-N-(naphthalene-1-sulfonyl)-5,6,7,8-tetrahydroisoquinoline-8-carboxamide; (1S)-4-cyclobutyl-7-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4-cyclobutyl-7-methoxy-N-(1-methyl-1H-benzimidazole-7-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 7-methoxy-N-(naphthalene-1-sulfonyl)-4-(prop-1-en-2-yl)-2,3-dihydro-1H-indene-1-carboxamide; 4-(2-hydroxypropan-2-yl)-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-cyclobutyl-7-methoxy-N-(1-methyl-1H-benzimidazole-7-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4-cyclobutyl-7-methoxy-N-(2-methylquinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-cyclobutyl-7-methoxy-N-(2-methylquinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-cyclobutyl-7-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4-cyclobutyl-7-methoxy-N-(1,2,3,4-tetrahydroquinoline-8-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-cyclobutyl-7-methoxy-N-(1,2,3,4-tetrahydroquinoline-8-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 2-cyclobutyl-5-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; 4-cyclobutyl-7-methoxy-N-(1-methyl-1H-benzimidazole-7-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 2-cyclobutyl-5-methoxy-N-(1-methyl-1H-benzimidazole-7-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; 4-cyclobutyl-7-methoxy-N-(pyrazolo[1,5-a]pyridine-4-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 2-cyclobutyl-5-methoxy-N-(pyrazolo[1,5-a]pyridine-4-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; 2-cyclobutyl-5-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; 7-methoxy-N-(naphthalene-1-sulfonyl)-4-(oxolan-2-yl)-2,3-dihydro-1H-indene-1-carboxamide; 7-methoxy-4-(methoxymethyl)-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 7-methoxy-4-(2-methylpropyl)-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4-cyclobutyl-7-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-cyclobutyl-7-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (7S)-2-cyclobutyl-5-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (7R)-2-cyclobutyl-5-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (7S)-2-cyclobutyl-5-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (7R)-2-cyclobutyl-5-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (7S)-2-cyclobutyl-5-methoxy-N-(quinoline-5-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; (7R)-2-cyclobutyl-5-methoxy-N-(quinoline-5-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; 7-methoxy-3,3-dimethyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-4-cyclobutyl-7-methoxy-N-(pyrazolo[1,5-a]pyridine-4-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 7-methoxy-3,3-dimethyl-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-7-methoxy-3,3-dimethyl-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-7-methoxy-3,3-dimethyl-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (7R)-2-cyclobutyl-5-methoxy-N-(3-methylimidazo[1,2-a]pyridine-5-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; N-(benzenesulfonyl)-4-chloro-1-methyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-methyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-6-chloro-1-methyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)-6-chloro-1-methyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-chlorobenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-methoxy-N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5,6-dimethoxy-N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-chloro-N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 6-fluoro-N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1R)-5-methoxy-N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1S)\u2014N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 6,7-dimethoxy-N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-methoxy-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-2-carboxamide; (1R)\u2014N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1S)-6-methoxy-1-methyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 7-chloro-1-methyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4,5-difluoro-1-methyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 1-methyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 1,5-dimethyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-ethylbenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-ethylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(3-chlorobenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(4-chlorobenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-fluorobenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4-chloro-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-chlorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(2-nitrobenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-(3,6-dihydro-2H-pyran-4-yl)-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-cyclobutyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-phenyl-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-[2-(trifluoromethyl)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; N-(2-fluorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2-bromobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-[(propan-2-yl)oxy]-2,3-dihydro-1H-indene-1-carboxamide; 7-bromo-4-methoxy-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-(2-methoxypyridin-4-yl)-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 5-methoxy-N-(quinoline-8-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; (1R)-5-methoxy-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-5-methoxy-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; (1S)-4-methoxy-1-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(naphthalene-1-sulfonyl)-1-[(pyrrolidin-1-yl)methyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-2-carboxamide; 1-methyl-N-(naphthalene-1-sulfonyl)-6-(trifluoromethoxy)-2,3-dihydro-1H-indene-1-carboxamide; 8-bromo-5-hydroxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5,6-dimethoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-amide; N-(naphthalene-1-sulfonyl)-2,3,7,8,9,10-hexahydronaphtho[1,2-b][1,4]dioxine-7-carboxamide; 6,7-dimethoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-N-(2-chlorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(2-methoxybenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-[5-methyl-2-(propan-2-yl)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-[3-chloro-2-(methoxymethyl)benzene-1-sulfonyl]-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(2-fluorobenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(2-phenoxybenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-[2-(trifluoromethoxy)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-[2-(difluoromethoxy)benzene-1-sulfonyl]-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,5-dimethylbenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-[2-(2-methoxyethoxy)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; N-([1,1\u2032-biphenyl]-2-sulfonyl)-4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(naphthalene-2-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(benzenesulfonyl)-4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; N-(2,1,3-benzothiadiazole-4-sulfonyl)-4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(naphthalene-1-sulfonyl)-1-[(oxolan-3-yl)methyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(naphthalene-1-sulfonyl)-1-[2-(1H-pyrazol-1-yl)ethyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-[(5-methoxypyridin-2-yl)methyl]-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-[(2-methoxypyridin-4-yl)methyl]-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(naphthalene-1-sulfonyl)-1-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,3-dihydro-1,4-benzodioxine-5-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(4-bromonaphthalene-1-sulfonyl)-4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(4-fluoronaphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(5-bromonaphthalene-1-sulfonyl)-4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(5,6,7,8-tetrahydronaphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(3,4-dihydroquinoline-1(2H)-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-(hydroxymethyl)-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-cyclobutyl-N-(4-cyclobutylnaphthalene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-cyclobutyl-N-(5-cyclobutylnaphthalene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 8-bromo-5-(cyclohexylmethoxy)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-bromo-5-[(3-methoxyphenyl)methoxy]-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-bromo-5-[(3-methoxyphenyl)methoxy]-N-[(3-methoxyphenyl)methyl]-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; ethyl({4-bromo-5-[(naphthalene-1-sulfonyl)carbamoyl]-5,6,7,8-tetrahydronaphthalen-1-yl}oxy)acetate; 8-bromo-5-(cyclopentyloxy)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-(benzyloxy)-8-bromo-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; N-benzyl-5-(benzyloxy)-8-bromo-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-bromo-N-(naphthalene-1-sulfonyl)-5-[(oxetan-3-yl)oxy]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-bromo-N-(naphthalene-1-sulfonyl)-5-[(oxan-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-bromo-5-(2-hydroxy-2-methylpropoxy)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 6,8-dimethoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-8-[4-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-8-[(E)-2-phenylethenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-(2,2-difluoro-2H-1,3-benzodioxol-4-yl)-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-(2-fluoro-4-methylphenyl)-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-8-(2-phenoxyphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; N-(3-bromo-2-methylbenzene-1-sulfonyl)-4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(3-fluoro-2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-[2-(methoxymethyl)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,3-difluorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-[2-(2,2-difluoroethoxy)benzene-1-sulfonyl]-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(quinoxaline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(3-chloro-2-fluorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,3-dichlorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(1-methyl-1H-indole-3-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 5-[2-(1,3-dioxan-2-yl)ethyl]-8-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-cyano-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 5-cyano-8-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-N-(3-cyclobutyl-2-methylbenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(isoquinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; 8-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-bromo-7-methoxy-N-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-N-(8-fluoroquinoline-5-sulfonyl)-7-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 7-ethyl-5-methoxy-N-(naphthalene-1-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; 8-methoxy-N-(naphthalene-1-sulfonyl)-5-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-methoxy-N-(naphthalene-1-sulfonyl)-5-[(E)-2-phenylethenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-(3,6-dihydro-2H-pyran-4-yl)-8-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-methoxy-8-(6-methylpyridin-3-yl)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-bromo-N-(2-ethoxyquinoline-5-sulfonyl)-7-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 8-methoxy-N-(naphthalene-1-sulfonyl)-5-(pyrrolidin-1-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-1-ethyl-N-[2-methyl-3-(piperidin-1-yl)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-[3-(3,3-difluoroazetidin-1-yl)-2-methylbenzene-1-sulfonyl]-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-[3-(3,3-difluoropyrrolidin-1-yl)-2-methylbenzene-1-sulfonyl]-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 5-chloro-8-hydroxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-8-[6-(trifluoromethyl)pyridin-3-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-(3,6-dihydro-2H-pyran-4-yl)-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-(6-cyclopropylpyridin-3-yl)-5-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-bromo-7-methoxy-N-[2-(propan-2-yl)quinoline-5-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-methoxy-N-(5-methoxynaphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; methyl 7-methoxy-1-[(naphthalene-1-sulfonyl)carbamoyl]-2,3-dihydro-1H-indene-4-carboxylate; methyl 5-[(4-bromo-7-methoxy-2,3-dihydro-1H-indene-1-carbonyl)sulfamoyl]naphthalene-1-carboxylate; 5-chloro-8-[2-(morpholin-4-yl)ethoxy]-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-1-methyl-N-(phenylmethanesulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(1,3,5-trimethyl-1H-pyrazole-4-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-methoxyethanesulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(propane-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 8-methoxy-N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-2-carboxamide; 5-methoxy-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-2-carboxamide; 4-methoxy-N-(1,3,5-trimethyl-1H-pyrazole-4-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(2-methoxybenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(5-methylpyridine-2-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(oxane-4-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(3-methoxypropane-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(2-methoxyethanesulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(propane-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-methoxybenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(5-methylpyridine-2-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(4-hydroxybenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(phenylmethanesulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(6-hydroxynaphthalene-2-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(5-acetamido-1,3,4-thiadiazole-2-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-[5-methyl-2-(propan-2-yl)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; N-[4-(methanesulfonyl)benzene-1-sulfonyl]-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(3-nitrobenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(4-chloro-3-nitrobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(6-chloro-1,1-dioxo-1,2-dihydro-1\u03bb 6 ,2,4-benzothiadiazine-7-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(2-methyl-5-nitrobenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(4-acetamido-2-methylbenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-chlorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-chloro-2-nitrobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(naphthalene-2-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(3-chlorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-[4-(3-oxobutanamido)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; N-(2,4-dichlorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-amino-2-chloro-5-methylbenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2-chloro-5-methylbenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2-chloro-5-nitrobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-acetamidobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-acetamido-2-chlorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-butanamidobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2,4-dihydroxy-6-methylpyrimidine-5-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-cyanobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(2-oxo-2H-1-benzopyran-6-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; ethyl 4-[(4-methoxy-2,3-dihydro-1H-indene-1-carbonyl)sulfamoyl]benzoate; N-(2,4-dimethyl-3-nitrobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-{2-chloro-5-[(2,6-dimethylphenyl)carbamoyl]-4-hydroxybenzene-1-sulfonyl}-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-[1-(2-chloroethyl)-3,5-dimethyl-1H-pyrazole-4-sulfonyl]-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-[3-({[(2S)-1-ethylpyrrolidin-2-yl]methyl}carbamoyl)-4-methoxybenzene-1-sulfonyl]-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(6-ethoxy-1,3-benzothiazole-2-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-hexanoylbenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-[4-(4-{2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl}piperazin-1-yl)benzene-1-sulfonyl]-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; propan-2-yl 2-[(4-methoxy-2,3-dihydro-1H-indene-1-carbonyl)sulfamoyl]benzoate; N-{4-[(3-hydroxy-3-methylbutyl)amino]-3-nitrobenzene-1-sulfonyl}-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-[2-chloro-5-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)benzene-1-sulfonyl]-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-{7-[(4-chlorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine-8-sulfonyl}-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(9-benzyl-1,3-dimethyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purine-8-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-{4-[(dimethylamino)methyl]benzene-1-sulfonyl}-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2-cyano-3-fluorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-hydroxy-3-nitrobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(3-cyanobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(5-bromopyridine-3-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(6-hydroxypyridine-3-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(4-cyano-1,3-dimethyl-1H-pyrazole-5-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; tert-butyl 5-[(4-methoxy-2,3-dihydro-1H-indene-1-carbonyl)sulfamoyl]-1,3-dimethyl-1H-pyrazole-4-carboxylate; N-[4-(hydroxymethyl)-1,3-dimethyl-1H-pyrazole-5-sulfonyl]-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(3-chloro-2-fluorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2,6-difluorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4,5-dimethoxy-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(5-chloro-2-fluorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2,5-difluorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2-chloro-5-fluorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2,6-dichlorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2,4-difluorobenzene-1-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-[1-(2-methoxyethyl)-1H-pyrazole-4-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; N-(3,5-dimethyl-1,2-oxazole-4-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(2,4-dimethyl-1,3-thiazole-5-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(pyridine-3-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 2-[(4-methoxy-2,3-dihydro-1H-indene-1-carbonyl)sulfamoyl]-N,N-dimethylpyridine-3-carboxamide; N-(2-cyanopyridine-3-sulfonyl)-4-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-methoxy-N-(pyridine-2-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-(6-methoxypyridin-3-yl)-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-[6-(piperidin-1-yl)pyridin-3-yl]-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(2-methylpyridin-3-yl)-2,3-dihydro-1H-indene-1-carboxamide; 4-(6-fluoropyridin-3-yl)-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-[6-(dimethylamino)pyridin-3-yl]-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-(5-fluoropyridin-3-yl)-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(5-methylpyridin-3-yl)-2,3-dihydro-1H-indene-1-carboxamide; 4-(2-fluoropyridin-4-yl)-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-(3-fluoropyridin-4-yl)-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(3-methylpyridin-4-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(2-methylpyridin-4-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(1H-pyrazol-4-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(1H-pyrazol-5-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(thiophen-3-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-[6-(morpholin-4-yl)pyridin-3-yl]-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(3-methyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(1-methyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(5-methylfuran-2-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(2-methylfuran-3-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-methylbenzene-1-sulfonyl)-4-(1-methyl-1H-pyrazol-5-yl)-2,3-dihydro-1H-indene-1-carboxamide; (1R)\u2014N-(2-aminopyridine-3-sulfonyl)-5-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide; N-(6-aminopyridine-2-sulfonyl)-1,5-dimethyl-2,3-dihydro-1H-indene-1-carboxamide; (1R)\u2014N-(6-aminopyridine-2-sulfonyl)-5-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide; N-(6-aminopyridine-2-sulfonyl)-8-chloro-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-N-(naphthalene-1-sulfonyl)-1-[2-(pyrrolidin-1-yl)ethyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-{2-[(2-methoxyethyl)(methyl)amino]ethyl}-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,4-dichlorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,4-dimethylbenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,6-difluorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,5-dichlorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(3-chlorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-chloro-5-methylbenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-[4-(trifluoromethoxy)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-cyanobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,6-dimethoxybenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-[2-(trifluoromethyl)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2,3-dihydro-1,4-benzodioxine-6-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-chloro-6-methylbenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(4-chlorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-[2-methyl-6-(trifluoromethyl)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-cyano-3-fluorobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(1-methylcyclopropane-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-([1,1\u2032-biphenyl]-4-sulfonyl)-4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-{4-[(dimethylamino)methyl]benzene-1-sulfonyl}-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(2-chloropyridine-3-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(quinoline-6-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 2-[(4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carbonyl)sulfamoyl]-N,N-dimethylpyridine-3-carboxamide; 4-chloro-N-(cyclohexanesulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-{4-[4-(propan-2-yl)piperazin-1-yl]pyridine-3-sulfonyl}-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-{2-[2-(piperidin-1-yl)ethoxy]benzene-1-sulfonyl}-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(phenylmethanesulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindole-4-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(4-methoxybenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(4-phenoxybenzene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(3-cyanobenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-(1H-pyrazole-3-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 3-{4-chloro-1-[naphthalene-1-sulfonyl)carbamoyl]-2,3-dihydro-1H-inden-1-yl}propanoic acid; 4-chloro-N-(naphthalene-1-sulfonyl)-1-[(pyridin-2-yl)methyl]-2,3-dihydro-1H-indene-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-8[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; methyl 2-chloro-6-[(4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carbonyl)sulfamoyl]benzoate; 4-chloro-1-ethyl-N-methyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-(methoxymethyl)-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-hydroxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 5-methoxy-8-(morpholin-4-yl)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-8-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-1-(cyanomethyl)-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-N-(3-chloro-2-methylbenzene-1-sulfonyl)-1-ethyl-2,3-dihydro-1H-indene-1-carboxamide; 8-chloro-1-cyano-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-bromo-7-methoxy-N-(2-methoxypyridine-3-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; N-(2-aminopyridine-3-sulfonyl)-4-bromo-7-methoxy-2,3-dihydro-1H-indene-1-carboxamide; N-(6-aminopyridine-2-sulfonyl)-4-bromo-7-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-N-(4-ethoxynaphthalene-1-sulfonyl)-7-methoxy-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-methoxy-N-(4-methoxynaphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-bromo-7-methoxy-N-([1,2,4]triazolo[4,3-a]pyridine-8-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 8-methoxy-N-(naphthalene-1-sulfonyl)-5-(pyrimidin-5-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 5-(6-cyclopropylpyridin-3-yl)-8-methoxy-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-methoxy-N-(naphthalene-1-sulfonyl)-5-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-methoxy-5-(6-methylpyridin-3-yl)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 7-methoxy-4-(pyrimidin-5-yl)-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 4-(3,6-dihydro-2H-pyran-4-yl)-7-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 8-methoxy-5-(4-methylphenyl)-N-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 8-methoxy-N-(naphthalene-1-sulfonyl)-5-[6-(trifluoromethyl)pyridin-3-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 4-chloro-1-ethyl-N-[2-methyl-3-(morpholin-4-yl)benzene-1-sulfonyl]-2,3-dihydro-1H-indene-1-carboxamide; 4-chloro-1-ethyl-N-{3-[(2-methoxyethyl)(methyl)amino]-2-methylbenzene-1-sulfonyl}-2,3-dihydro-1H-indene-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-8-(pyrrolidin-1-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide; 2,3-dimethoxy-N-(2-methylbenzene-1-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; N-(2-methylbenzene-1-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; 2,3-dimethoxy-N-(naphthalene-1-sulfonyl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide; 2-methoxy-N-(naphthalene-1-sulfonyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-5-carboxamide; 2-chloro-6-[(4-chloro-1-ethyl-2,3-dihydro-1H-indene-1-carbonyl)sulfamoyl]benzoic acid; 1-methoxy-N-(naphthalene-1-sulfonyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-7-carboxamide; 5-[(4-bromo-7-methoxy-2,3-dihydro-1H-indene-1-carbonyl)sulfamoyl]naphthalene-1-carboxylic acid; 7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 7-methoxy-1-[(naphthalene-1-sulfonyl)carbamoyl]-2,3-dihydro-1H-indene-4-carboxylic acid; methyl 7-methoxy-3-[(naphthalene-1-sulfonyl)carbamoyl]-2,3-dihydro-1H-indene-4-carboxylate; 4-(hydroxymethyl)-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1-carboxamide; 7-methoxy-N 4 -methyl-N 1 -(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1,4-dicarboxamide; 7-methoxy-N 4 ,N 4 -dimethyl-N 1 -(naphthalene-1-sulfonyl)-2,3-dihydro-1H-indene-1,4-dicarboxamide; and 7-methoxy-N-(naphthalene-1-sulfonyl)-4-[pyrrolidin-1-yl)methyl]-2,3-dihydro-1H-indene-1-carboxamide.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.41379
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15902802', '15726075', '15723896', '15205512', '15496094']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8449421867685507
- 35 USC 102 Novelty (BERT): 0.5828945599576897
- Combined Prediction Score: 0.8187374240874646
- Mean Citation Score: 420.78830199999993
- Max Citation Score: 502.06512
- Similarity Product: 432.58588183768273

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test