PATENT CLAIM ANALYSIS

Application Number: 15757027
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-10
Patent Classification: ["546", "197000"]

Abstract:
The present invention provides an improved process for the preparation of N-protected ((3S,4R)-4-(4-fluorophenyl)piperidin-3-yl)methanol (compound (A)) and further its transformation to Paroxetine and its pharmaceutically acceptable salts. The process comprises reaction of compound (II) with amido-malonate compound (C) in the presence of a chiral catalyst and optionally a dehydrating agent to obtain compound (B); followed by reduction of (B) in the presence of a reducing agent to provide compound (A).

Claim (Index 4):
The process according to the  claim 1 , wherein the reducing agent is selected from the group consisting of hydrides selected from sodium borohydride, potassium borohydride, lithium borohydride, zinc borohydride, sodium cyanoborohydride, sodium sulfurated borohydride, sodium trioxyacetal borohydride, sodium tri-alkoxy borohydride, sodium hydroxyl borohydride, sodium borohydride anilide, tetrahydrofuran borohydride, di-methyl-butyl borohydride, lithium-aluminum hydride, lithium-aluminum tri-oxymethyl hydride, sodium-aluminum-2-methoxy-ethoxy hydride, and aluminum hydride and/or mixtures thereof; borane-tetrahydrofuran (THF), borane-dimethylsulfide (DMS) and sodium borohydride/BF 3 -Etherate.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 90.0
- Lexical Diversity: 1.81132
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14891028', '10488842', '11892785', '15322581', '13119743']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8022150516899679
- 35 USC 102 Novelty (BERT): 0.4869324732384322
- Combined Prediction Score: 0.7706867938448143
- Mean Citation Score: 212.217208
- Max Citation Score: 231.76048
- Similarity Product: 174.87027933834077

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test