PATENT CLAIM ANALYSIS

Application Number: 15944336
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["549", "265000"]

Abstract:
Provided is a compound that comprises the structure: where SIG is a signaling molecule and R 3  is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.

Claim (Index 1):
A method of determining whether at least one molecule inhibits an enzyme that removes a myristoyl moiety from an \u03b5-amino of a lysine, the method comprising:\n (a) mixing the enzyme and a molecule with a compound having the formula wherein\n SIG is a fluorophore or luminescent moiety, and \n m is an integer from 1 to 10; \n (b) incubating the enzyme-molecule-compound mixture under conditions and for a time sufficient for the enzyme to remove the myristoyl moiety in the absence of the molecule; and (c) determining whether the myristoyl moiety is removed from the compound to an equivalent degree that the myristoyl moiety would be removed from the compound in the absence of the molecule, wherein the failure of the removal of the myristoyl moiety from the compound to an equivalent degree as in the absence of the molecule indicates that the molecule is an inhibitor of the enzyme.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 91.0
- Lexical Diversity: 2.80435
- Patent Class: 549.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15464966', '12930693', '13808706', '13698561', '13516190']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7132338031134281
- 35 USC 102 Novelty (BERT): 0.7278036421513048
- Combined Prediction Score: 0.7146907870172158
- Mean Citation Score: 499.612722
- Max Citation Score: 793.6410000000003
- Similarity Product: 778.882788240552

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test