PATENT CLAIM ANALYSIS

Application Number: 16200334
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["424", "423000"]

Abstract:
Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Claim (Index 27):
A method of making hydrogel capsules encapsulating cells,\n wherein the capsules consist of three layers: an inner acellular core layer, a hydrogel layer containing cells to be transplanted selected from the group consisting of mammalian secretory cells, mammalian metabolic cells, mammalian structural cells, and aggregates thereof, and an outer acellular barrier or structural layer, the method comprising: providing an electrospraying device with a nozzle that consists of three separate concentric tubes at its outlet; pumping a hydrogel forming material, optionally including one or more anti-inflammatory drugs or imaging reagents, into the innermost tube of the nozzle; pumping a second stream that contains hydrogel forming material and cells to be encapsulated into the middle tube of the nozzle; pumping a third stream that contains a hydrogel forming material into the outermost tube, wherein the three streams meet at the outlet of the nozzle, and the viscosity of the hydrogel solution prevents any significant intermixing among the three streams, so that droplets with three distinct concentric layers are formed under the electric field; and allowing the droplets to fall into a gel bath which contains divalent ions to crosslink the hydrogel and form and triple-layer capsules.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 98.0
- Lexical Diversity: 1.58333
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14776639', '13831250', '13400382', '15831570', '15317657']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7885743552172784
- 35 USC 102 Novelty (BERT): 0.6051908285887768
- Combined Prediction Score: 0.7702360025544281
- Mean Citation Score: 458.67156000000006
- Max Citation Score: 582.405
- Similarity Product: 473.2300980323553

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test