PATENT CLAIM ANALYSIS

Application Number: 15763366
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "518000"]

Abstract:
Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Claim (Index 93):
The method of any one of  claims 70 - 92 , wherein the compound that inhibits ATR is represented by Formula A-I-a: or a pharmaceutically acceptable salt thereof; wherein: Ring A is J 5 o is H, F, Cl, C 1-4 aliphatic, O(C 1-3 aliphatic), or OH; J 5 p is J 5 p1 is H, C 1-4 aliphatic, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl; wherein J 5 p1 is optionally substituted with 1-2 occurrences of OH or halo; J 5 p2 is H, methyl, ethyl, CH 2 F, CF 3 , or CH 2 OH; J 2 o is H, CN, or SO 2 CH 3 ; J 2 m is H, F, Cl, or methyl; J 2 p is \u2014SO 2 (C 1-6 alkyl), \u2014SO 2 (C 3-6 cycloalkyl), \u2014SO 2 (4-6 membered heterocyclyl), \u2014SO 2 (C 1-4 alkyl)N(C 1-4 alkyl) 2 , or \u2014SO 2 (C 1-4 alkyl)-(4-6 membered heterocyclyl), wherein said heterocyclyl contains 1 heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur; and wherein said J 2 p is optionally substituted with 1-3 occurrences halo, OH, or O(C 1-4 alkyl).

Metadata:
- Claim Count in Document: 59.0
- Percentile: 90.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15031426', '15665506', '12988755', '14596052', '15081076']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.808240294727938
- 35 USC 102 Novelty (BERT): 0.523854472725178
- Combined Prediction Score: 0.7798017125276621
- Mean Citation Score: 311.3153240000001
- Max Citation Score: 332.41208
- Similarity Product: 224.3313391254329

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test