PATENT CLAIM ANALYSIS

Application Number: 15887299
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["424", "139100"]

Abstract:
The invention relates to the treatment of bone disorders. In particular, the invention is directed to the use of a dosing holiday to help overcome the resistance to anti-sclerostin antibodies which develops over time when a plurality of doses of antibody are given to a subject. By giving the subject to be treated such a dosing holiday, the subject may subsequently display an increased response to a subsequent dose of the anti-sclerostin antibody. The subject may be given multiple cycles of a batch of at least two doses of anti-sclerostin antibody and a dosing holiday. In some instances, the subject may be monitored to help determine when to give the dosing holiday. Further, the subject may be given a different treatment for the bone disorder during the dosing holiday from the anti-sclerostin antibody.

Claim (Index 9):
The method of any one of  claims 1  and  4  to  7 , wherein:\n (i) the batch of doses in (a) comprises from three to seven doses of anti-sclerostin antibody; \n (ii) the batch of doses in (a) comprises at least four doses of anti-sclerostin antibody; \n (iii) the interval between doses in (a) is about a day, two days, three days, four days, five days, six days, a week, two weeks, four weeks, eight weeks, a month or about two months in length; \n (iv) the batch of doses in (a) comprises twelve doses, with the doses given at about monthly or four weekly intervals; \n (v) the dosing holiday of (b) is at least about six weeks, seven weeks, eight weeks, one month, two month or three months in length; and/or \n (vi) in (c) the batch of doses administered is as defined in any of (i) to (iv).

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 2.16667
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13934433', '13090075', '13860954', '13090058', '12212327']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.747545234698612
- 35 USC 102 Novelty (BERT): 0.6179634570876771
- Combined Prediction Score: 0.7345870569375185
- Mean Citation Score: 509.410518
- Max Citation Score: 712.5443
- Similarity Product: 465.4766841448069

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test