PATENT CLAIM ANALYSIS

Application Number: 15909447
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["506", "009000"]

Abstract:
A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.

Claim (Index 2):
A method of identifying a compound having a selected property of interest in a library of compounds, each of said compounds being bound to its respective solid support, and being produced by a unique reaction series composed of N reaction steps, wherein each compound is prepared from a component, and N is an integer from at least 1 to about 100, which comprises:\n a) dividing a population of solid supports having at least one type of a first functional group at the surface of said solid support selected from the group consisting of CO 2 H, OH, SH, NH 2 , NHR, CH 2 Cl, CH 2 Br and CHN 2 , wherein R is a linear C 1 -C 9  alkyl group, into M batches, wherein M is an integer from at least 2 to about 25; b) coupling the M batches of solid support in a set of at least one reaction respectively with M different components so as to form a bond with the solid support via said first functional group, said components being independently optionally protected; c) adding to each batch, optionally prior to coupling step b), concurrently therewith, or subsequently to step b), from about 0.001 to about 0.5 molar equivalent of a spectrally distinguishable fluorophore tag associated uniquely with each component, said tag being identified by its characteristic excitation wavelength(s), emission wavelength(s), excited state lifetime and emission intensity, said tag being activated so as to be capable of forming either a direct bond to the surface of the solid support, optionally via a second functional group which is optionally protected and may be the same as or different from the first functional group bonded to the component, or an indirect bond via a C 1 -C 9  linear or branched alkyl linker moiety which is optionally interrupted by at least one oxygen or nitrogen atom or a carbonyl, (C\u2550O)NH or NH(C\u2550O) moiety, wherein when said second functional group is protected, said functional group is deprotected prior to forming said direct or indirect bond, said linker being bonded to the second functional group at the surface of the solid support; d) optionally recombining all M batches, said recombining step optionally being subsequent to step e); e) performing an assay capable of indicating that any compound in the library either while bound to or cleaved from its solid support has the property of interest; f) collecting spectral fluorescence data for each respective solid support so as to determine respective relative abundances of the fluorophore tags bound thereto; g) analyzing the collected spectral fluorescence data by comparing the respective relative abundances of the fluorophore tags determined in step f) so as to determine the unique reaction series for the compound, thereby identifying the compound having the property of interest.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 90.0
- Lexical Diversity: 1.32075
- Patent Class: 506.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14607496', '09448420', '10529397', '12555707', '11584880']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6171223662820234
- 35 USC 102 Novelty (BERT): 0.567888946417293
- Combined Prediction Score: 0.6121990242955504
- Mean Citation Score: 294.545102
- Max Citation Score: 452.4951
- Similarity Product: 362.1848001496196

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test