PATENT CLAIM ANALYSIS

Application Number: 15874338
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["530", "300000"]

Abstract:
The present invention is directed to an inventive polymeric carrier molecule according to generic formula (I) and variations thereof, which allows for efficient transfection of nucleic acids into cells in vivo and in vitro, a polymeric carrier cargo complex formed by a nucleic acid and the inventive polymeric carrier molecule, but also to methods of preparation of this inventive polymeric carrier molecule and of the inventive polymeric carrier cargo complex. The present invention also provides methods of application and use of this inventive polymeric carrier molecule and the inventive polymeric carrier cargo complex as a medicament, for the treatment of various diseases, and in the preparation of a pharmaceutical composition for the treatment of such diseases.

Claim (Index 13):
Method of preparing a polymeric carrier molecule as defined in  claim 1  comprising following steps\n a) providing at least one cationic or polycationic protein or peptide as component P 2  as defined herein and/or at least one cationic or polycationic polymer as component P 2  as defined according to  claim 1 , and optionally at least one further component (AA) x , mixing these components, preferably in a basic milieu, preferably in the presence of oxygen or a further starter which leads to mild oxidation conditions, and thereby condensing and thus polymerizing these components with each other via disulfide bonds in a polymerization condensation or polycondensation to obtain a repetitive component H\u2014[S\u2014P 2 \u2014S] n \u2014H or H{[S\u2014P 2 \u2014S] a [S-(AA) x -S] b }H; \n b) providing a hydrophilic polymer P 1  and/or P 3  as defined according to  claim 1 , optionally modified with a ligand L and/or an amino acid component (AA) x  as defined according to  claim 1 ; \n c) mixing the hydrophilic polymer P 1  and/or P 3  according to step b) with the repetitive component H\u2014[S\u2014P 2 \u2014S] n \u2014H or H{[S\u2014P 2 \u2014S] a [S-(AA) x -S] b }H obtained according to step a) in a ratio of about 2:1, and thereby typically terminating the polymerization condensation or polycondensation reaction and obtaining the inventive polymeric carrier molecule according to formula (I) or (Ia); \n d) optionally purifying the polymeric carrier molecule obtained according to step c).

Metadata:
- Claim Count in Document: 22.0
- Percentile: 86.0
- Lexical Diversity: 2.15517
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14195864', '13378241', '15065769', '13824449', '15206036']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7743125668375479
- 35 USC 102 Novelty (BERT): 0.7209235587668835
- Combined Prediction Score: 0.7689736660304816
- Mean Citation Score: 736.1370539999997
- Max Citation Score: 869.1829
- Similarity Product: 765.3155078065515

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test