PATENT CLAIM ANALYSIS

Application Number: 16065880
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["544", "293000"]

Abstract:
The invention relates to Crystal form I and Crystal form II of dihydrochloride of N-(4-((3-chloro-4-fluorophenyl)amino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazoli n-6-yl)acrylamide represented by the following Formula (I), and preparation methods therefor, wherein the Crystal form I has an X-ray powder diffraction pattern having characteristic peaks at the 2θ positions of 6.0±0.2°, 7.3±0.2°, 11.7±0.2°, 12.9±0.2°, 18.4±0.2°, 24.7±0.2°, and 26.3±0.2°, as determined by using Cu-Kα radiation, and the Crystal form II has an X-ray powder diffraction pattern having characteristic peaks at the 2θ positions of 5.0±0.2°, 7.0±0.2°, 10.1±0.2°, 17.0±0.2°, 26.0±0.2°, and 26.5±0.2°, as determined by using Cu-Kα radiation.

Claim (Index 13):
A method for preparing the Crystal form II according to  claim 7 , comprising the following steps: N-(4-((3-chloro-4-fluorophenyl)amino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl)acrylamide is dissolved in water or in a mixed solvent of water and an organic solvent, and subjected by addition of concentrated hydrochloric acid to produce a solution, then the solution was filtrated and dried to obtain Crystal form II.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 98.0
- Lexical Diversity: 1.94118
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16065884', '14127824', '13701704', '15328795', '15748283']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7503244059312157
- 35 USC 102 Novelty (BERT): 0.6076410002781086
- Combined Prediction Score: 0.7360560653659051
- Mean Citation Score: 370.674532
- Max Citation Score: 546.69147
- Similarity Product: 484.3230432620393

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test