PATENT CLAIM ANALYSIS

Application Number: 16188988
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["514", "217050"]

Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Claim (Index 1):
A compound represented by Formula (I), or a pharmaceutically acceptable salt thereof: wherein:\n \u00c2 is selected from the group consisting of:\n 1) Optionally substituted heteroaryl; and \n 2) Optionally substituted aryl; \n \n {circumflex over (B)} is selected from the group consisting of:\n 1) Optionally substituted heteroaryl; and \n 2) Optionally substituted aryl; \n \n L is \u2014NH\u2014, \u2014NHC(O)\u2014, or \u2014NHC(O)NH\u2014; \n R 1  is selected from the group consisting of:\n 1) Optionally substituted heteroaryl; and \n 2) Optionally substituted aryl; \n \n R 2  is hydrogen, halogen, or optionally substituted \u2014CH 3 ; \n R 3  is the same or different and independently selected from halogen, hydroxyl, protected hydroxyl, cyano, amino, protected amino, nitro, optionally substituted \u2014C 1 -C 8  alkyl, optionally substituted \u2014C 1 -C 8  alkoxy, optionally substituted \u2014NHC 1 -C 8  alkyl, optionally substituted \u2014S\u2014(\u2014C 1 -C 8  alkyl), optionally substituted \u2014SO 2 \u2014(\u2014C 1 -C 8  alkyl),\u2014optionally substituted \u2014SO 2 \u2014NH\u2014(\u2014C 1 -C 8  alkyl), optionally substituted \u2014NH\u2014SO 2 \u2014(\u2014C 1 -C 8  alkyl), \u2014CO 2 R 12 , \u2014NR 13 R 14 , and \u2014CO\u2014NR 13 R 14 ; \n R 12  is selected from the group consisting of:\n 1) Optionally substituted \u2014C 1 -C 8  alkyl; \n 2) Optionally substituted \u2014C 2 -C 8  alkenyl; \n 3) Optionally substituted \u2014C 2 -C 8  alkynyl; \n 4) Optionally substituted \u2014C 3 -C 8  cycloalkyl; \n 5) Optionally substituted \u2014C 3 -C 8  cycloalkenyl; \n 6) Optionally substituted 3- to 8-membered heterocycloalkyl; \n 7) Optionally substituted aryl; and \n 8) Optionally substituted heteroaryl; \n \n R 13  and R 14  are each independently selected from hydrogen, optionally substituted \u2014C 1 -C 8 -alkyl, optionally substituted \u2014C 2 -C 8 -alkenyl, optionally substituted \u2014C 2 -C 8 -alkynyl; optionally substituted \u2014C 3 -C 8 -cycloalkyl; optionally substituted \u2014C 3 -C 8  cycloalkenyl; optionally substituted 3- to 12-membered heterocycloalkyl, optionally substituted aryl; optionally substituted heteroaryl; optionally substituted \u2014C 1 -C 8 -alkoxy, \u2014C(O)R 12 , \u2014S(O) 2 R 12 , and \u2014S(O) 2 NHR 12 ; alternatively, R 13  and R 14  are taken together with the nitrogen they attached to form a heterocyclic ring; \n R 4  is absent or is selected from the group consisting of:\n 1) Optionally substituted \u2014C 1 -C 8  alkyl; \n 2) Optionally substituted \u2014C 2 -C 8  alkenyl; \n 3) Optionally substituted \u2014C 2 -C 8  alkynyl; \n 4) Optionally substituted \u2014C 1 -C 8  alkoxy; \n 5) Optionally substituted aryloxy; \n 6) Optionally substituted \u2014C 3 -C 12  cycloalkyl; \n 7) Optionally substituted \u2014C 3 -C 12  cycloalkenyl; \n 8) Optionally substituted 3- to 12-membered heterocycloalkyl; \n 9) Optionally substituted aryl; \n 10) Optionally substituted arylalkyl; \n 11) Optionally substituted heteroaryl; \n 12) Optionally substituted heteroarylalkyl; \n 13) \u2014NR 13 R 14 ; \n 14) \u2014CO\u2014NR 13 R 14 ; and \n 15) \u2014SO 2 \u2014NR 13 R 14 ; \n \n R 5  is selected from hydrogen and optionally substituted \u2014C 1 -C 8  alkyl; and n is 0 to 3, provided that when is heteroaryl, n is no greater than the total number of CH and NH groups in \u00c2 when \u00c2 is unsubstituted.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 98.0
- Lexical Diversity: 1.63265
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15863216', '15216119', '15914016', '12259483', '11503502']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8223070991758842
- 35 USC 102 Novelty (BERT): 0.5291806060187312
- Combined Prediction Score: 0.7929944498601689
- Mean Citation Score: 318.27413799999994
- Max Citation Score: 351.35507
- Similarity Product: 309.7742186913509

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test