PATENT CLAIM ANALYSIS

Application Number: 15890561
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["435", "440000"]

Abstract:
Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.

Claim (Index 21):
A method for modifying a target DNA sequence in a mammalian cell, the method comprising:\n (a) introducing a single-stranded DNA (ssDNA) in the mammalian cell, the ssDNA comprising a 5\u2032 homology arm having substantial sequence identity to the target DNA sequence, an exogenous sequence, and a 3\u2032 homology arm having substantial sequence identity to the target DNA sequence, wherein the ssDNA is between 200 and 2,000 nucleotides in length, (b) introducing or expressing a CRISPR/Cas9 system in the mammalian cell, under conditions wherein the CRISPR/Cas9 system cuts the target DNA sequence and the ssDNA is recombined with the target DNA sequence.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 88.0
- Lexical Diversity: 1.71053
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14319380', '14948221', '15251235', '14226274', '14105017']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6210634335368735
- 35 USC 102 Novelty (BERT): 0.5222983594969758
- Combined Prediction Score: 0.6111869261328837
- Mean Citation Score: 313.73494
- Max Citation Score: 345.81247
- Similarity Product: 253.8310413097668

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test