PATENT CLAIM ANALYSIS

Application Number: 15743546
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["546", "153000"]

Abstract:
Compounds that inhibit Myeloid Cell Leukemia-1 (Mcl-1) oncoprotein, and methods of using the same, are provided for treating disease.

Claim (Index 10):
The compound of  claim 9 , wherein the compound is selected from the group consisting of 4-(N-isobutyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)benzoic acid,\n 4-(N-isobutylnaphthalene-2-sulfonamido)benzoic acid, 2-hydroxy-4-(N-isobutylphenylsulfonamido)benzoic acid, 2-hydroxy-4-(N-isobutyl-4-methylphenylsulfonamido)benzoic acid, 4-(4-bromo-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 2-hydroxy-4-(N-isobutyl-4-(p-tolyloxy)phenylsulfonamido)benzoic acid, 4-(4-(3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 4-(4-(2,4-dichlorophenoxy)-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 2-hydroxy-4-(4-phenoxyphenylsulfonamido)benzoic acid, 3-(N-isobutylphenylsulfonamido)benzoic acid, 3-(N-isobutyl-4-methylphenylsulfonamido)benzoic acid, 2-hydroxy-5-(N-isobutylnaphthalene-2-sulfonamido)benzoic acid, 5-(4-(4-chloro-3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, methyl 2-hydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzoate, 4-(N-benzyl-4-phenoxyphenylsulfonamido)-2-hydroxy-N-(phenylsulfonyl)benzamide, 4-(N-benzyl-4-phenoxyphenylsulfonamido)-2-hydroxy-N-(methylsulfonyl)benzamide, 4-(N-isobutyl-4-phenoxyphenylsulfonamido)-2-((4-(((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)carbamoyl)benzyl)oxy)benzoic acid, 4-(4-fluoro-N-isobutylphenylsulfonamido)benzoic acid, 4-(4-(4-chloro-3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)benzoic acid, 2-hydroxy-4-(N-isobutylnaphthalene-2-sulfonamido)benzoic acid, 2-hydroxy-4-(N-isobutyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)benzoic acid, 4-(N-cyclopentyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)-2-hydroxybenzoic acid, 4-(N-cyclopentylnaphthalene-2-sulfonamido)-2-hydroxybenzoic acid, 4-(4-(4-chloro-3,5-dimethylphenoxy)-N-cyclopentylphenylsulfonamido)-2-hydroxybenzoic acid, 3-(N-isobutylnaphthalene-2-sulfonamido)benzoic acid, 3-(N-isobutyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)benzoic acid, 3-(4-(4-chloro-3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)benzoic acid, phenyl 2-hydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzoate, acetoxymethyl 2-hydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzoate, N-(4-cyano-3-hydroxyphenyl)-N-isobutyl-4-phenoxybenzenesulfonamide, 4-(N-benzyl-4-phenoxyphenylsulfonamido)-2-hydroxy-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide, 4-(N-benzyl-4-(4-chloro-3,5-dimethylphenoxy)phenylsulfonamido)-2-hydroxy-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide, 3-(4-(4-chloro-3,5-dimethylphenoxy)-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 4-(4-fluoro-N-isobutylphenylsulfonamido)-2-hydroxybenzoic acid, 2-hydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzoic acid, 4-(N-benzyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)-2-hydroxybenzoic acid, 4-(N-benzylnaphthalene-2-sulfonamido)-2-hydroxybenzoic acid, 4-(N-benzyl-4-(4-chloro-3,5-dimethylphenoxy)phenylsulfonamido)-2-hydroxybenzoic acid, 3-(4-fluoro-N-isobutylphenylsulfonamido)benzoic acid, 2-hydroxy-5-(N-isobutylphenylsulfonamido)benzoic acid, 2-hydroxy-5-(N-isobutyl-[1,1\u2032-biphenyl]-4-ylsulfonamido)benzoic acid, N-(4-(2H-tetrazol-5-yl)phenyl)-N-isobutyl-4-phenoxybenzenesulfonamide, N,2-dihydroxy-4-(N-isobutyl-4-phenoxyphenylsulfonamido)benzamide, N-isobutyl-N-(4-(3-oxo-2,3-dihydroisoxazol-5-yl)phenyl)-4-phenoxybenzenesulfonamide, 5-(N-benzyl-4-(4-chloro-3,5-dimethylphenoxy)phenylsulfonamido)-2-hydroxybenzoic acid, 5-(N-benzyl-4-(4-chloro-3,5-dimethylphenoxy)phenylsulfonamido)-2-hydroxy-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide, and the pharmaceutically acceptable salts, solvates, hydrates, cocrystals, or prodrugs thereof.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 86.0
- Lexical Diversity: 1.04348
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12104294', '12096393', '14763468', '13823810', '13526337']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7877153908610426
- 35 USC 102 Novelty (BERT): 0.5137510244709348
- Combined Prediction Score: 0.7603189542220319
- Mean Citation Score: 268.77087199999994
- Max Citation Score: 276.15472
- Similarity Product: 184.69752650839808

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test