PATENT CLAIM ANALYSIS

Application Number: 15923139
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "450000"]

Abstract:
A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution.

Claim (Index 37):
A method for treating or preventing cancer or infectious disease in a subject, comprising administering to the subject an effective amount of a nanolipogel selected from the group consisting of:\n (a) a nanolipogel comprising a polymeric matrix core formed of one or more polymers or copolymers and a lipid shell; wherein the polymeric matrix core has at least one host molecule dispersed therein or covalently bound thereto, wherein the host molecule is reversibly associated with a first active agent; and wherein the nanolipogel includes at least one additional active agent provided in the polymeric matrix core or in or on the lipid shell; for controlled release of said first active agent and said at least one additional active agent from the nanolipogel; (b) a nanolipogel comprising: a polymeric matrix formed of a polymer selected from the group consisting of crosslinked polymer, amphiphilic polymer, block copolymer, and tri-block copolymer having dispersed therein or covalently bound thereto host molecules which reversibly complex with or bind an agent, wherein the host molecules are selected from the group consisting of polysaccharides, cryptands, cryptophanes, cavitands, crown ethers, dendrimers, catenanes, carcerands, carbon nanotubes, fullerenes, inorganic phosphates, and silica, for controlled release of at least one therapeutic, diagnostic or prophylactic agent, and a lipid shell; and (c) a nanolipogel comprising a polymeric matrix core having dispersed therein or covalently bound thereto host molecules for controlled release of at least one therapeutic, diagnostic or prophylactic agent, and a lipid shell, wherein the host molecule reversibly complexes with or binds an agent, wherein the host molecule is selected from the group consisting of polysaccharides, cryptands, cryptophanes, cavitands, crown ethers, dendrimers, catenanes, carcerands, carbon nanotubes, fullerenes, inorganic phosphates, and silica.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 90.0
- Lexical Diversity: 1.57303
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14394161', '14394147', '15434971', '14537541', '15752008']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.769690914160749
- 35 USC 102 Novelty (BERT): 0.7039997753051614
- Combined Prediction Score: 0.7631218002751903
- Mean Citation Score: 472.26945799999993
- Max Citation Score: 740.7355299999997
- Similarity Product: 661.7473039648173

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test