PATENT CLAIM ANALYSIS

Application Number: 15928906
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["562", "495000"]

Abstract:
A method for producing a compound of formula (I) or a pharmaceutically acceptable salt, solvate, tautomer or stereoisomer, such as compound 1 and compound 2 is disclosed. The method proceeds through an O-allylated tyrosine-based compound, such as compound 3 and preferably comprises [3,3] sigmatropic Claisen rearrangement and olefin cross metathesis reactions. In addition, a pharmaceutical composition comprising a compound of formula (I) a tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL) and a pharmaceutically acceptable carrier or excipient is disclosed.

Claim (Index 1):
A method for making a prenyl group-substituted tyrosine compound of formula (I) a pharmaceutically acceptable salt, solvate, tautomer, stereoisomer or combination thereof; wherein R 1  is an optionally substituted alkyl, optionally substituted cycloalkyl, or optionally substituted aryl; R 2  is \u2014OH, \u2014NH 2 , OR 6 , \u2014NHR 6 , or \u2014NR 6 R 6 ; R 3  is \u2014H, \u2014R 6 , \u2014COR 6 , \u2014COOR 6 , or \u2014SO 2 R 6 ; R 4  and R 5  are independently \u2014H, \u2014OH, \u2014NH 2 , \u2014OR 6 , \u2014NHR 6 , \u2014NR 6 R 6 ; each R 6  is independently an optionally substituted alkyl, optionally substituted cycloalkyl, or optionally substituted aryl; R 7  and R 8  are independently optionally substituted alkyl, optionally substituted cycloalkyl, or optionally substituted aryl; the method comprising: rearranging, in an uncatalyzed intramolecular sigmatropic rearrangement, an O-allylated tyrosine-based compound of the formula to form a rearranged tyrosine-based compound having an allyl group and a phenolic hydroxyl group of the formula reacting the phenolic hydroxyl group of the rearranged tyrosine-based compound with acetic anhydride; then olefin cross metathesizing the allyl group with an alkene in the presence of a metal complex catalyst to form the prenyl group-substituted tyrosine compound of formula (I).

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.59677
- Patent Class: 562.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14918658', '12093867', '13771546', '15398851', '12093874']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6638802746542645
- 35 USC 102 Novelty (BERT): 0.5551298382318416
- Combined Prediction Score: 0.6530052310120222
- Mean Citation Score: 271.73047
- Max Citation Score: 399.2035
- Similarity Product: 321.2626672543884

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test