PATENT CLAIM ANALYSIS

Application Number: 15976736
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "009600"]

Abstract:
Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Claim (Index 23):
A mucus-penetrating anti-microbial composition for urogenital delivery, the composition comprising a plurality of coated particles, wherein the coated particles comprise:\n a core particle comprising an anti-microbial agent, wherein the anti-microbial agent constitutes at least 80 wt % of the core particle; and a coating comprising a surface-altering agent surrounding the core particle, wherein the surface-altering agent comprises a triblock copolymer comprising a hydrophilic block\u2014hydrophobic block\u2014hydrophilic block configuration, wherein the hydrophobic block has a molecular weight of at least 2 kDa, and the hydrophilic blocks constitute at least 15 wt % of the triblock copolymer, and wherein the hydrophobic block associates with the surface of the core particle and renders the coated particle hydrophilic; and wherein the coated particles have an average size of at least 5 nm and less than or equal to 1000 nm.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 93.0
- Lexical Diversity: 1.6962
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15616799', '15354704', '13886493', '14731972', '15187552']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8436483339003138
- 35 USC 102 Novelty (BERT): 0.6487242655361743
- Combined Prediction Score: 0.8241559270639
- Mean Citation Score: 669.16904
- Max Citation Score: 688.2753
- Similarity Product: 593.7166725804807

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test