PATENT CLAIM ANALYSIS

Application Number: 16044252
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-03
Patent Classification: ["424", "178100"]

Abstract:
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Claim (Index 297):
A composition comprising CTLA4 A29YL104E -Ig molecules comprising:\n (a) an average molar ratio of sialic acid to CTLA4 A29YL104E -Ig molecules of at least about 5; (b) an average molar ratio of N-acetyl neuraminic acid (NANA) to CTLA4 A29YL104E Ig molecules of from about 5 to about 10; (c) an average molar ratio of N-glycolyl neuramininic acid (NGNA) to CTLA4 A29YL104E -Ig molecules less than or equal to 1.5; (d) an average molar ratio of N-Acetylgalactosamine (GalNAc) to CTLA4 A29YL104E -Ig molecules from about 2.7 to about 3.6; (e) an average molar ratio of N-Acetylglucosamine (GlcNAc) to CTLA4 A29YL104E -Ig molecules from about 24 to about 28; (f) an average molar ratio of galactose to CTLA4 A29YL104E -Ig molecules from about 9.2 to about 17; (g) an average molar ratio of fucose to CTLA4 A29YL104E -Ig molecules from about 4.2 to about 7.0; (h) an average molar ratio of mannose to CTLA4 A29YL104E -Ig molecules from about 10 to about 20; and (i) less than or equal to 5.0 area percent high molecular weight species as determined by size exclusion chromatography and spectrophotometric detection, wherein the CTLA4 A29YL104E -Ig molecules comprise one or more CTLA4 A29YL104E -Ig polypeptides having the amino acid sequence set forth in SEQ ID NO: 4, 11, 12, 13, 14, 15, or 16.

Metadata:
- Claim Count in Document: 91.0
- Percentile: 95.0
- Lexical Diversity: 1.82143
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12086786', '12763902', '12251960', '13049727', '13045335']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7001112253433165
- 35 USC 102 Novelty (BERT): 0.6096251523564008
- Combined Prediction Score: 0.691062618044625
- Mean Citation Score: 346.666068
- Max Citation Score: 729.3368
- Similarity Product: 458.0230040397644

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test