PATENT CLAIM ANALYSIS

Application Number: 15878295
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["514", "019300"]

Abstract:
Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cell. The therapeutic component may be subsequently released within an endocytic vesicle of the target cell. Nanoparticle-based drug delivery systems as described herein may provide improved efficacy and/or reduced toxicity.

Claim (Index 20):
A method of constructing a nanoparticle-based drug delivery system, the method comprising:\n adding quantities of a first component, a second component, and a third component to a solvent in a predetermined molar ratio, wherein the first component comprises a targeting molecule coupled to a first lipid molecule, the second component comprises a therapeutic agent coupled to a second lipid molecule, and the third component comprises polyethylene glycol (PEG); and mixing said components in the solvent to form a plurality of nanoparticles that include said components in the predetermined molar ratio, wherein the nanoparticles have a hydrophobic interior portion surrounded by an outer portion, the first and second lipid molecules are disposed in the interior portion, and the PEG, the targeting molecule, and the therapeutic agent are disposed in the outer portion.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 86.0
- Lexical Diversity: 1.80328
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14356121', '15413267', '14765620', '15301020', '12573591']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6964797234319047
- 35 USC 102 Novelty (BERT): 0.5459542601191014
- Combined Prediction Score: 0.6814271771006244
- Mean Citation Score: 256.094844
- Max Citation Score: 401.60403
- Similarity Product: 320.9142806309938

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test