PATENT CLAIM ANALYSIS

Application Number: 15746050
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-10
Patent Classification: ["424", "134100"]

Abstract:
The present invention relates to agents for reducing the activity of GDF15 and in particular the use of such agents to treat or prevent conditions associated with elevated or unwanted levels of GDF15. The invention is based on the discovery that GDF15 binds to the receptors CLPTM1 and QRFPR and provides agents for such use in the form of binding agents capable of binding to the receptors and inhibiting the interaction between GDF15 and the receptor. Further agents include polypeptides derived from the receptors which are capable of binding to GDF15 and inhibiting its interaction with the receptors. Also provided are diagnostic methods based on detecting the interaction or an effect thereof, and cytotoxic immune cells modified to have a reduced level and/or activity of CLPTM1.

Claim (Index 65):
The method of  claim 63 , wherein said polypeptide:\n (i) comprises an amino acid sequence as set forth in SEQ ID NO:5 (extracellular domain 3 of QRFPR), SEQ ID NO:12 (extracellular domain 4 of QRFPR) or SEQ ID NO:14 (extracellular domain of CLPTM1) or SEQ ID NO:315 (extracellular domain of CLPTM1 with N-terminal methionine), wherein the amino acid sequence is not flanked at either or both ends by an amino acid sequence which flanks the said amino acid sequence in a native QRFPR or CLPTM1 receptor, or comprises an amino acid sequence which is not the amino acid sequence of SEQ ID NOs: 5, 12, 14, or 315 but which has at least 75% sequence identity to SEQ ID NO:5, 12, 14, or 315 wherein optionally the amino acid sequence is not flanked at either or both ends by an amino acid sequence which flanks the said amino acid sequence in a native QRFPR or CLPTM1 receptor; or (ii) is or comprises a part of SEQ ID NO:5, 12, 14 or 315, said part comprising at least 6 contiguous amino acids of SEQ ID NO:5, 12, 14 or 315 wherein (i) at least 2 contiguous or non-contiguous amino acids of SEQ ID NO:5, 12, 14 or 315 are deleted and/or (ii) said part is not flanked at either or both ends by an amino acid sequence which flanks the said amino acid sequence in a native QRFPR or CLPTM1 receptor; or (iii) comprises an amino acid sequence having at least 6 amino acids corresponding to at least 6 contiguous amino acids of SEQ ID NO:5, 12, 14 or 315 and has at least 75% sequence identity to the equivalent amino acid sequence in SEQ ID NO:5, 12, 14 or 315, wherein (i) at least 2 contiguous or non-contiguous amino acids of SEQ ID NO:5, 12, 14 or 315 are deleted and/or (ii) the amino acid sequence corresponding to SEQ ID NO:5, 12, 14 or 315 is not flanked at either or both ends by an amino acid sequence which flanks the said amino acid sequence in a native QRFPR or CLPTM1 receptor.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.87143
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15714015', '13078728', '15044883', '13974792', '15231309']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6677822535362191
- 35 USC 102 Novelty (BERT): 0.5236880119583465
- Combined Prediction Score: 0.6533728293784319
- Mean Citation Score: 281.044742
- Max Citation Score: 292.85443
- Similarity Product: 184.046960502249

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test