PATENT CLAIM ANALYSIS

Application Number: 15942587
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-02
Patent Classification: ["514", "04400A"]

Abstract:
The present application relates to nucleic acid compounds, compositions comprising same and methods of use thereof for treatment of various diseases, disorders and conditions. The compounds are preferably chemically synthesized and modified double-stranded nucleic acid molecules which down regulate expression of a p53 gene.

Claim (Index 34):
The molecule or the pharmaceutically acceptable salt of such molecule of  claim 29 , wherein the molecule having a sense strand and an antisense strand: 5\u2032\u2003cap-GGGCCUGACUCAGAC U GAU-C3-pi 3\u2032sense strand (SEQ ID NO: 19)   5\u2032\u2003AU C AGU c U GAGU C AGGCCC-C3-C3 3\u2032antisense strand (SEQ ID NO: 32); wherein each of A, U, G and C is an unmodified ribonucleotide; wherein each of  U  and  C  is a 2\u2032-O-methyl sugar modified ribonucleotide; wherein c is a ribonucleotide joined to an adjacent ribonucleotide in a 5\u2032>3\u2032 direction by a 2\u2032-5\u2032 internucleotide phosphate bond; wherein in the antisense strand and in the sense strand, each consecutive ribonucleotide is joined to the next ribonucleotide by a phosphodiester bond; wherein the sense strand comprises a 1,3-propanediol, mono(dihydrogen phosphate) i.e. C3 non-nucleotide overhang covalently attached at the 3\u2032 terminus of the sense strand; wherein the sense strand comprises a 5\u2032 cap z\u2033 covalently attached at the 5\u2032 terminus of the sense strand; wherein the antisense strand comprises a C3-C3 non-nucleotide overhang covalently attached at the 3\u2032 terminus of the antisense strand; and wherein the 3\u2032 terminus of the sense strand is phosphorylated, represented by pi.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 91.0
- Lexical Diversity: 1.26316
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14421845', '14426513', '13700942', '15433400', '13521033']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8275474806116356
- 35 USC 102 Novelty (BERT): 0.5833877400707889
- Combined Prediction Score: 0.803131506557551
- Mean Citation Score: 425.007888
- Max Citation Score: 516.79877
- Similarity Product: 407.8754594668406

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test