PATENT CLAIM ANALYSIS

Application Number: 16044217
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-03
Patent Classification: ["424", "178100"]

Abstract:
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Claim (Index 297):
A composition comprising cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig) molecules, wherein the CTLA4-Ig composition comprises\n (a) an average molar ratio of sialic acid to CTLA4-Ig molecules of at least about 8; (b) an average molar ratio of N-acetyl neuraminic acid (NANA) to CTLA4-Ig molecules of from about 8 to about 12; (c) an average molar ratio of N-glycolyl neuramininic acid (NGNA) to CTLA4-Ig molecules less than or equal to 1.5; (d) an average molar ratio of N-Acetylgalactosamine (GalNAc) to CTLA4-Ig molecules from about 1.7 to about 3.6; (e) an average molar ratio of N-Acetylglucosamine (GlcNAc) to CTLA4-Ig molecules from about 15 to about 35; (f) an average molar ratio of galactose to CTLA4-Ig molecules from about 8.0 to about 17; (g) an average molar ratio of fucose to CTLA4-Ig molecules from about 3.5 to about 8.3; (h) an average molar ratio of mannose to CTLA4-Ig molecules from about 7.7 to about 22; and (i) less than or equal to 5.0 area percent high molecular weight species as determined by size exclusion chromatography and spectrophotometric detection, and wherein the CTLA4-Ig molecules comprise one or more CTLA4-Ig polypeptides having the amino acid sequence set forth in SEQ ID NO: 2, 5, 6, 7, 8, 9, or 10.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 95.0
- Lexical Diversity: 1.85714
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12086786', '13796586', '12763902', '12251960', '13045335']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6876662454768805
- 35 USC 102 Novelty (BERT): 0.6246520210050003
- Combined Prediction Score: 0.6813648230296925
- Mean Citation Score: 330.338242
- Max Citation Score: 703.0169
- Similarity Product: 499.8847577797234

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test