PATENT CLAIM ANALYSIS

Application Number: 16040684
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["514", "006200"]

Abstract:
The novel insulin derivates delivers, after administration to humans, insulin as a function of the glucose concentration in the tissue.

Claim (Index 2):
An insulin derivative of formula I: (Z 1 \u2014Y 1 X 1 ) m -Ins-(X\u2014Y\u2014Z) n  wherein n is zero or 1; m is zero or 1; with the proviso that not both n and m are zero;\n Ins represents insulin or an insulin analogue optionally having an A22 lysine, each Ins having an A chain and a B chain having a B29 lysine residue, from which a hydrogen atom has been removed from an \u03f5 amino group present in the B29 lysine residue, from an \u03f5 amino group present in the optional A22 lysine residue, or from a \u03f5 amino groups present in both the B29 and optional A22 lysine residues, and wherein the amino group present in the N terminal amino acid residue in the A chain, B chain, or both A and B chains, optionally, is substituted by one or two alkyl groups, and wherein \u2014X\u2014Y\u2014 or \u2014X 1 \u2014Y 1 \u2014Z 1  is independently attached to the \u03f5 amino group in one or both of the B29 lysine or A22 lysine residues in the insulin or insulin analogue; X and X 1 , independently of each other, is a bond, a \u03b3-glutamyl group wherein the amino group is connected to the Y/Y 1  moiety or a moiety of formula \u2014CO\u2014(C 1 -C 3 -alkylene)-SO 2 \u2014NH\u2014, wherein the amino group is connected to the Y/Y 1  moiety; Y and Y 1 , independently of each other, is \u03c9-amino alkanoyl group is a straight or branched alkyl group containing 6 to 22 carbon atoms and wherein a hydrogen atom has been removed from the \u03c9-amino group; and Z and Z 1 , independently of each other, is \u2014SO 2 \u2014Ar or \u2014CO\u2014Ar, wherein Ar is a phenyl group substituted by one or more \u2014B(OH) 2  groups and, optionally, substituted by one or more halogen atoms; with the proviso that if Z or Z 1  is \u2014SO 2 \u2014Ar, then X or X 1  is not a bond.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 95.0
- Lexical Diversity: 1.15
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12935438', '14126215', '13224538', '12673516', '15121206']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8369359357845989
- 35 USC 102 Novelty (BERT): 0.5743638973798333
- Combined Prediction Score: 0.8106787319441224
- Mean Citation Score: 445.473044
- Max Citation Score: 501.0652
- Similarity Product: 379.1866687949896

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test