PATENT CLAIM ANALYSIS

Application Number: 16126897
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "001000"]

Abstract:
Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R 1 , R 2 , R 3 , R 4 , R 5 , R 8 , Z, W, Y, and Z are as defined herein.

Claim (Index 86):
A method of treating a disease, disorder, or condition from which a subject suffers, comprising administering to a subject in need thereof an effective amount of a composition comprising an agent and a compound of Formula (III): or salt thereof, with the cell under conditions sufficient to facilitate delivery of an agent into the interior of the cell; wherein:\n p is 1; \n each instance of Q is O; \n each instance of R 1  is independently hydrogen, alkyl, or a group of formula (iv); \n provided at least one instance of R 1  is a group of formula: \n L is alkylene; R 6  and R 7  are each independently hydrogen, alkyl, a nitrogen protecting group, or a group of the formula (i), (ii), or (iii); each instance of R 2  is independently hydrogen, alkyl, a nitrogen protecting group, or a group of the formula (i), (ii), or (iii); Formulae (i), (ii), and (iii) are: wherein each instance of formula (i) is independently formula (i-a) or formula (i-b): each instance of R\u2032 is independently hydrogen or alkyl; X is O, S, or NR X , wherein R X  is hydrogen or a nitrogen protecting group; Y is O; R P  is hydrogen, alkyl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, or a nitrogen protecting group when attached to a nitrogen atom; and R L  is C 6-50  alkyl, provided that at least one instance of R 2 , R 6 , or R 7  is a group of the formula (i), (ii), or (iii); wherein each alkyl and alkylene is independently unsubstituted or substituted at one or more positions with a group selected from halogen, \u2014CN, \u2014NO 2 , \u2014OH, \u2014OR aa , \u2014N(R bb ) 2 , \u2014N(R bb ) 3 + X \u2212 , \u2014N(OR cc )R bb , \u2014SH, \u2014SR aa , \u2014C(\u2550O)R aa , \u2014CO 2 H, \u2014CHO, \u2014C(OR cc ) 2 , \u2014CO 2 R aa , \u2014OC(\u2550O)R aa , \u2014OCO 2 R aa , \u2014C(\u2550O)N(R bb ) 2 , \u2014OC(\u2550O)N(R bb ) 2 , \u2014NR bb C(\u2550O)R aa , \u2014NR bb CO 2 R aa , \u2014NR bb C(\u2550O)N(R bb ) 2 , \u2014C(\u2550NR bb )R aa , \u2014C(\u2550NR bb )OR aa , \u2014OC(\u2550NR bb )R aa , \u2014OC(\u2550NR bb )OR aa , \u2014C(\u2550NR bb )N(R bb ) 2 , \u2014OC(\u2550NR bb )N(R bb ) 2 , \u2014NR bb C(\u2550NR bb )N(R bb ) 2 , C 3-14  carbocyclyl, 3-14 membered heterocyclyl, C 6-14  aryl, and 5-14 membered heteroaryl, wherein each alkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 groups selected from halogen, \u2014OH, \u2014OR ee , and C 1-50 alkyl; or two geminal hydrogens on a carbon atom are replaced with the group \u2550O; each instance of R aa  is, independently, selected from C 1-50 alkyl; each instance of R bb  is, independently, selected from hydrogen, and C 1-50  alkyl; each instance of R cc  is, independently, selected from C 1-50  alkyl, and C 3-10  carbocyclyl; wherein X \u2212  is a counterion.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 97.0
- Lexical Diversity: 2.01149
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15340082', '13662002', '14647198', '15721393', '15305845']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7806521032432665
- 35 USC 102 Novelty (BERT): 0.6249889512084876
- Combined Prediction Score: 0.7650857880397886
- Mean Citation Score: 521.11864
- Max Citation Score: 647.4456
- Similarity Product: 496.5061583101272

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test