PATENT CLAIM ANALYSIS

Application Number: 15779087
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "04400A"]

Abstract:
It was determined that plasma-derived exosomes from either obese (OB) or obstructive sleep apnea (OSA) children with evidence of endothelial dysfunction (ED). Such ED exosomes lead to up-regulation of adhesion molecules in endothelial cells. Exosomal miRNA cargo differences underlie the mechanisms accounting for the presence of ED. Specifically, expression of miRNA-630 is reduced in circulating exosomes of either obese or OSA children with ED, and normalizes in OSA children with ED after treatment along with restoration of endothelial function. These findings elucidate a novel role of exosomal miRNA-630 as a putative key mediator of vascular function and a biomarker of cardiovascular disease (CVD) risk in children.

Claim (Index 1):
A system and method of diagnosing endothelial dysfunction as described herein, in any embodiment and any configuration.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.63514
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15790962', '14421355', '14748215', '14420680', '14561585']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7363756507357128
- 35 USC 102 Novelty (BERT): 0.516706765127645
- Combined Prediction Score: 0.714408762174906
- Mean Citation Score: 218.96218800000003
- Max Citation Score: 235.89357
- Similarity Product: 129.7466264614177

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test