PATENT CLAIM ANALYSIS

Application Number: 16183530
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-02
Patent Classification: ["536", "024500"]

Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

Claim (Index 1):
A short interfering RNA (siRNA) molecule having a sense strand and an antisense strand that mediates RNA interference, wherein:\n (a) each strand is between 18 and 24 nucleotides in length; (b) the sense strand comprises 10 or more 2\u2032-deoxy, 2\u2032-O-methyl, 2\u2032-deoxy-2\u2032-fluoro, or universal base modified nucleotides, and a terminal cap molecule at the 3\u2032-end, the 5\u2032-end, or both 3\u2032 and 5\u2032-ends of the sense strand; (c) the antisense strand comprises 10 or more 2\u2032-deoxy, 2\u2032-O-methyl, 2\u2032-deoxy-2\u2032-fluoro, or universal base modified nucleotides; (d) 10 or more pyrimidine nucleotides of the sense and/or antisense strand are 2\u2032-deoxy, 2\u2032-O-methyl or 2\u2032-deoxy-2\u2032-fluoro nucleotides; and (e) at least one strand comprises a compound having Formula 119: wherein W comprises a linker molecule or chemical linkage that can be present or absent, each R7 independently comprises an acetyl group, and each n is independently an integer from 1 to 20.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 98.0
- Lexical Diversity: 1.83099
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14514112', '10720448', '13480655', '14731346', '15677719']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7918242194362474
- 35 USC 102 Novelty (BERT): 0.6978705023029039
- Combined Prediction Score: 0.7824288477229131
- Mean Citation Score: 752.0730120000003
- Max Citation Score: 759.4065
- Similarity Product: 736.302905964464

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test