PATENT CLAIM ANALYSIS

Application Number: 16089505
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["546", "115000"]

Abstract:
The present invention relates to an improved process for the preparation of Butorphanol tartrate of formula (I),

Claim (Index 1):
An improved process for the preparation of Butorphanol tartrate of formula (I), comprising the steps of:\n (a) obtaining a compound of formula (IV) by reacting a compound of formula (II) with a compound of formula (III) in suitable conditions; \n (b) resolving a compound of formula (IV) to obtain a mixture of compound of formula (IVa) and (IVb) using a suitable resolving agent in a suitable solvent to further obtain a mixture of compound of formula (IVc) and (IVd); (c) protecting a compound of formula (IVc) with di-tert-butyl dicarbonate in presence of a suitable base in a suitable solvent to get a compound of formula (V); (d) obtaining a mixture of compound of formula (VIa) and (VIb) by the epoxidation of compound of formula (V) with peroxy acid in a suitable solvent; (e) obtaining a mixture of compound of formula (VIIa) and (VIIb) by acid catalyzed ring opening and deprotection of mixture of compounds of formula (VIa) and (VIb) with a suitable acid in a suitable organic solvent; (f) obtaining a mixture of compound of formula (VIIIa) and (VIIIb) by reacting a mixture of compound of formula (VIIa) and (VIIb) with cyclobutylmethyl bromide in presence of a suitable base in a suitable solvent; (g) cyclizing a mixture of compound of formula (VIIIa) and (VIIIb) with borane in presence of an anhydrous acid with or without suitable organic solvent to obtain a compound of formula (IX); (h) demethylating a compound of formula (IX) using a suitable demethylating agent in a suitable solvent to obtain Butorphanol of formula (X); and (i) obtaining Butorphanol tartrate salt of formula (I) from Butorphanol of formula (X) by using tartaric acid in a suitable organic solvent.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 97.0
- Lexical Diversity: 1.05263
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13045987', '11024029', '12538545', '10297224', '15615020']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7188506878560288
- 35 USC 102 Novelty (BERT): 0.4924773304350752
- Combined Prediction Score: 0.6962133521139334
- Mean Citation Score: 193.154638
- Max Citation Score: 218.60132
- Similarity Product: 162.1050528548241

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test