PATENT CLAIM ANALYSIS

Application Number: 16202210
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "230500"]

Abstract:
The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.

Claim (Index 46):
The method of any one of  claims 1 - 44 , wherein the HDAC11 inhibitor is a compound of Formula II: and pharmaceutically acceptable salts thereof, wherein: X 1 , X 2 , X 3 , X 4 , X 5 , and X 6  are each independently, at each occurrence, \u2014CR 1 R 2 \u2014, \u2014NR 3 \u2014, \u2014O\u2014, \u2014C(O)\u2014, \u2014S(O) 2 \u2014, \u2014S(O)\u2014, or \u2014S\u2014; Y 1 , Y 2 , and Y 3  are each independently N or CR 1 ; L is a bond, \u2014(CR 1 R 2 ) p \u2014, \u2014C(O)NR 3 \u2014, \u2014S(O) 2 \u2014, \u2014S(O) 2 NR 3 \u2014, \u2014S(O)\u2014, \u2014S(O)NR 3 \u2014, \u2014C(O)(CR 1 R 2 ) p O\u2014, or \u2014C(O)(CR 1 R 2 ) p \u2014; R is independently \u2014H, \u2014C 1 -C 6 alkyl, \u2014C 2 -C 6 alkenyl, \u2014C 4 -C 8 cycloalkenyl, \u2014C 2 -C 6 alkynyl, \u2014C 3 -C 8 cycloalkyl, \u2014O 5 -C 12 spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more \u2014OH, halogen, oxo, \u2014NO 2 , \u2014CN, \u2014R 1 , \u2014R 2 , \u2014SR 3 , \u2014OR 3 , \u2014NHR 3 , \u2014NR 3 R 4 , \u2014S(O) 2 NR 3 R 4 , \u2014S(O) 2 R 1 , \u2014C(O)R 1 , \u2014C(O)OR 1 , \u2014NR 3 S(O) 2 R 1 , \u2014S(O)R 1 , \u2014S(O)NR 3 R 4 , \u2014NR 3 S(O)R 1 , heterocycle, aryl, or heteroaryl; R 1  and R 2  are independently, at each occurrence, \u2014H, \u2014R 3 , \u2014R 4 , \u2014C 1 -C 6 alkyl, \u2014C 2 -C 6 alkenyl, \u2014C 4 -C 8 cycloalkenyl, \u2014C 2 -C 6 alkynyl, \u2014C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, \u2014OH, halogen, \u2014NO 2 , \u2014CN, \u2014NHC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014N(C 1 -C 6 alkyl)S(O) 2 R 5 , \u2014S(O) 2 (C 1 -C 6 alkyl), \u2014(C 1 -C 6 alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, or \u2014(CHR 5 ) p NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 5 , \u2014OR 3 , \u2014NHR 3 , \u2014NR 3 R 4 , \u2014S(O) 2 N(R 3 ) 2 \u2014, \u2014S(O) 2 R 5 , \u2014C(O)R 5 , \u2014C(O)OR 5 , \u2014NR 3 S(O) 2 R 5 , \u2014S(O)R 5 , \u2014S(O)NR 3 R 4 , \u2014NR 3 S(O)R 5 , heterocycle, aryl, or heteroaryl; or R 1  and R 2  can combine with the carbon atom to which they are both attached to form a spirocycle, spiroheterocycle, or spirocycloalkenyl; or R 1  and R 2 , when on adjacent atoms, can combine to form a cycloalkyl, a heterocycle, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, or a cycloalkenyl; or R 1  and R 2 , when on non-adjacent atoms, can combine to form an optionally bridging cycloalkyl, an optionally bridging heterocycle, or an optionally bridging cycloalkenyl; R 3  and R 4  are independently, at each occurrence, \u2014H, \u2014C 1 -C 6 alkyl, \u2014C 2 -C 6 alkenyl, \u2014C 4 -C 8 cycloalkenyl, \u2014C 2 -C 6 alkynyl, \u2014C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P, and O, \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 (C 1 -C 6 alkyl), \u2014(C 1 -C 6 alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, or \u2014(CHR 5 ) p N(C 1 -C 6 alkyl) 2 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 5 , \u2014O(C 1 -C 6 )alkyl, \u2014NH(C 1 -C 6 )alkyl, \u2014N(C 1 -C 6 alkly) 2 , \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 NHC 1 -C 6 alkyl, \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, \u2014S(O)R 5 , \u2014S(O)N(C 1 -C 6 alkyl) 2 , \u2014N(C 1 -C 6 alkyl)S(O)R 5 , heterocycle, aryl, or heteroaryl; R 5  is independently, at each occurrence, \u2014H, \u2014C 2 -C 6 alkenyl, \u2014C 4 -C 8 cycloalkenyl, \u2014C 2 -C 6 alkynyl, \u2014C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P and O, \u2014OH, halogen, \u2014NO 2 , \u2014CN, \u2014NHC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 NH(C 1 -C 6 alkyl), \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 C 1 -C 6 alkyl, \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, \u2014S(O)(C 1 -C 6 alkyl), \u2014S(O)N(C 1 -C 6 alkyl) 2 , \u2014N(C 1 -C 6 alkyl)S(O)(C 1 -C 6 alkyl) or \u2014(CH 2 ) p N(C 1 -C 6 alkyl) 2 ; p is 0, 1, 2, 3, 4, 5, or 6; n is 0, 1, 2, 3, or 4; m is 0, 1, or 2; q is 1 or 2; r is 1 or 2; wherein the sum q+r\u22643 and wherein the sum m+n\u22644.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 98.0
- Lexical Diversity: 1.17241
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16202207', '15234412', '13683880', '11687565', '14763013']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7915676423818268
- 35 USC 102 Novelty (BERT): 0.6139735686500276
- Combined Prediction Score: 0.7738082350086469
- Mean Citation Score: 375.980184
- Max Citation Score: 624.77814
- Similarity Product: 459.5391296580792

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test