PATENT CLAIM ANALYSIS

Application Number: 16060299
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "314000"]

Abstract:
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1 and ubiquitin C-terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of cancer. Compounds of the invention include compounds having the formula (I): pharmaceutically acceptable salt thereof, wherein R 1a , R 1b , R 1c , R 1d , R 1e , R 1f  and A are as defined herein.

Claim (Index 3):
The compound according to  claim 2 , wherein R 2  represents a 3 to 10 membered ring which is unsubstituted or substituted with one or more substituents selected from halogen, cyano, oxo, nitro, \u2014OR 6 , \u2014SR 6 , \u2014NR 6 R 7 , \u2014CONR 6 R 7 , \u2014NR 6 COR 7 , \u2014NR 6 CONR 7 R 8 , \u2014COR 6 , \u2014C(O)OR 6 , \u2014SO 2 R 6 , \u2014SO 2 NR 6 R 7 , \u2014NR 6 SO 2 R 7 , \u2014NR 6 SO 2 NR 7 R 8 , \u2014NR 6 C(O)OR 7 , optionally substituted \u2014C 1 -C 6  alkyl, optionally substituted \u2014C 1 -C 6  alkoxy, optionally substituted \u2014C 2 -C 6  alkenyl, optionally substituted C 2 -C 6  alkynyl, -Q 2 -R 6 , -Q 2 -NR 6 CONR 7 R 8 , -Q 2 -NR 6 R 7 , -Q 2 _COR 6 , -Q 2 -NR 6 COR 7 , -Q 2 -NR 6 C(O)OR 7 , -Q 2 -SO 2 R 6 , Q 2 -CONR 6 R 7 , -Q 2 -CO 2 R 6 , -Q 2 -SO 2 NR 6 R 7 , -Q 2 -NR 6 SO 2 R 7  and -Q 2 -NR 6 SO 2 NR 7 R 8 ;\n Q 2  represents a covalent bond, an oxygen atom, a sulphur atom, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014CO\u2014, or a C 1 -C 6  alkylene, or optionally substituted C 2 -C 6  alkenylene; and R 6 , R 7 , R 8  each independently represent hydrogen, optionally substituted C 1 -C 6  alkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted aryl, or an optionally substituted cycloalkyl.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 94.0
- Lexical Diversity: 1.65625
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16070936', '15894025', '15513125', '16078518', '15738900']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8360121716933133
- 35 USC 102 Novelty (BERT): 0.5702533205403412
- Combined Prediction Score: 0.8094362865780161
- Mean Citation Score: 442.800168
- Max Citation Score: 484.3908
- Similarity Product: 371.21703323485855

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test