PATENT CLAIM ANALYSIS

Application Number: 16136058
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["424", "139100"]

Abstract:
Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease. The peptide compositions contain constant domains from human IgG, camelid IgG, and/or shark IgNAR. The peptide compositions include heavy-chain only single-domain antibodies and compositions with one or more variable antigen binding domain bound to one or more constant domains.

Claim (Index 97):
A composition comprising:\n a polypeptide comprising the formula Vab1-L1-X\u2014R3-Y-L2-Vab2, wherein the Vab1 and Vab2 each independently comprises a variable antigen-binding domain from a camelid single-domain heavy chain antibody, wherein at least one of the variable antigen-binding domains comprises amino acids 1-127 of the amino acid sequence of SEQ ID NO: 11;\n wherein L1 and L2 each comprise a hinge region from a camelid single-domain heavy-chain only antibody; \n wherein X and Y are bifunctional linkers, selected from a maleimido-thiol conjugate and polyethylene glycol; and \n wherein R3 comprises all or a portion of at least one constant domain of human IgG CH2 or CH3 domain.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 97.0
- Lexical Diversity: 1.76364
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13736852', '13917010', '15507676', '15638820', '10450036']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6760413277595487
- 35 USC 102 Novelty (BERT): 0.6519120057470597
- Combined Prediction Score: 0.6736283955582998
- Mean Citation Score: 367.465558
- Max Citation Score: 623.1730299999998
- Similarity Product: 589.9799566590498

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test