PATENT CLAIM ANALYSIS

Application Number: 16322312
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-06
Patent Classification: ["424", "450000"]

Abstract:
The present invention provides a way to capture a biomolecule such as a protein in one or more layers of covalently bonded amorphous silica, forming a cage or shell which preserves the shape of the protein and prevents denaturation caused by heat and/or aging and/or non-physiological conditions, through unfolding and loss of secondary and/or higher order structure.

Claim (Index 24):
A method of enveloping a biomolecule with silica comprising:\n a) hydrolysing a silica starting material to produce a hydrolysed silica precursor, b) contacting the hydrolysed silica precursor with an aqueous solution comprising the biomolecule, wherein the silica precursor precipitates about the biomolecule, optionally wherein the method occurs in aqueous phase; or wherein the aqueous solution comprising the biomolecule further comprises a buffer and has a pH\u22656; or wherein the aqueous solution comprising the biomolecule and the buffer and has a pH in the range of 6.5\u2264pH\u22657.5, optionally wherein the pH is about 7; wherein the aqueous solution comprising the biomolecule has a concentration of the biomolecule which is less than that which causes spontaneous aggregation of the biomolecule.

Metadata:
- Claim Count in Document: 75.0
- Percentile: 99.0
- Lexical Diversity: 1.25
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['10814123', '14111305', '14650645', '11721728', '14374388']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6825266423476729
- 35 USC 102 Novelty (BERT): 0.4741206068747234
- Combined Prediction Score: 0.661686038800378
- Mean Citation Score: 131.735926
- Max Citation Score: 144.53966
- Similarity Product: 101.02792410826322

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test