PATENT CLAIM ANALYSIS

Application Number: 15756488
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["435", "006120"]

Abstract:
The present disclosure relates to methods of collecting exosomes and microvesicles (EMV) from urine, isolating corresponding mRNA, and analyzing expression patterns in order to diagnose and treat various post-kidney transplant complications. In particular, annexin1 mRNA expression patterns are analyzed through a unique diagnostic formula.

Claim (Index 6):
A method for screening a human subject for an expression of an RNA associated with a post-kidney transplant complication, the method comprising comparing an expression of said RNA in a vesicle isolated from a urine sample from said subject with an expression of said RNA in a vesicle isolated from a urine sample of a donor without post-kidney transplant complications, wherein said RNA associated with a post-kidney transplant complication is ANXA1, wherein an increase in said expression of said RNA of said subject compared to said expression of said RNA of said donor indicates said subject has a post-kidney transplant complication when said increase is beyond a threshold level,\n wherein said comparing said expression of said RNA in said vesicle isolated from said urine sample further comprises:\n (a) capturing said vesicle from said sample from said subject by moving said sample from said subject across a vesicle-capturing filter, \n (b) loading a lysis buffer onto said vesicle-capturing filter, thereby lysing said vesicle to release a vesicle-associated RNA, \n (c) quantifying said expression of said RNA associated with a post-kidney transplant complication in said vesicle-associated RNA by PCR.

Metadata:
- Claim Count in Document: 18.0
- Percentile: 88.0
- Lexical Diversity: 1.21429
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15526296', '14170132', '13710237', '14931716', '14591542']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5471171601150777
- 35 USC 102 Novelty (BERT): 0.5192015649296108
- Combined Prediction Score: 0.544325600596531
- Mean Citation Score: 271.914458
- Max Citation Score: 310.04675
- Similarity Product: 231.08935438892243

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test