PATENT CLAIM ANALYSIS

Application Number: 16063622
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "469000"]

Abstract:
Two isoforms of thyroid receptor alpha (THRα1 and THRα2) have been found to be associated with the growth of cancer. Use of inhibitors of THRα1 (Formula I) and/or agonists of THRα2 (Formula II) in the treatment of such cancers is disclosed. Treatment of other disorders associated with such receptors is also contemplated, as is the use of diagnostic methods for predicting therapeutic outcomes based on the levels of expression of THRα1 and THRaα2 in a tissue sample.

Claim (Index 37):
A method of treating a disease, disorder or condition that benefits from the upregulation of THR\u03b12, comprising administering an effective amount of one or more compounds of Formula (II), or a pharmaceutically acceptable salt and/or solvate thereof, to a subject in need thereof, wherein the compounds of Formula (II) are: wherein R 10  is selected from OH, C 1-6 alkyl, OC 1-6 alkyl and haloC 1-6 alkyl; R 11 , R 12  and R 13  are independently selected from H, halo, C 1-6 alkyl and OC 1-6 alkyl; R 14  is selected from H, halo and C 1-6 alkyl; X is selected from NH, O, C 1-6 alkylene, OC 1-6 alkylene and C 1-6 alkylene-O; n is 1 or 2; Z is selected from NH, O and C 1-6 alkylene; and one or more available hydrogens are optionally replaced with D and/or F; or a salt and/or solvate thereof; with proviso that when X is O, n is not 2.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 94.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15176812', '15539088', '14415061', '15712670', '15768257']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7828014150975838
- 35 USC 102 Novelty (BERT): 0.5045498128631383
- Combined Prediction Score: 0.7549762548741393
- Mean Citation Score: 267.61987
- Max Citation Score: 280.80325
- Similarity Product: 216.2324726877064

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test