PATENT CLAIM ANALYSIS

Application Number: 16049109
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["514", "04400A"]

Abstract:
The present invention encompasses a class of compounds known as splice modulating oligonucleotides (SMOs) that modulate pre-mRNA splicing, thereby affecting expression and functionality of a specific protein in a cell. The present invention further provides compositions and methods for modulating pre-mRNA splicing using a SMO of the invention to abrogate disease-causing mutations in a protein. Accordingly, the present invention provides compositions and methods of treating a subject at risk of, susceptible to, or having a disease, disorder, or condition associated with aberrant or unwanted target pre-mRNA expression or activity.

Claim (Index 6):
The composition of  claim 5 , wherein at least one nucleotide in said SMO contains a non-naturally occurring modification comprising one or more modification selected from phosphorothioate 2\u2032-O-methyl nucleotides, 2\u2032-O-methoxyethyl (2\u2032 MOE) nucleotides, locked nucleic acids (LNAs), peptide nucleic acids (PNAs), phosphorodiamidate morpholinos (PMOs), and cholesterol conjugates.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 95.0
- Lexical Diversity: 1.66667
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14188168', '13144409', '15833539', '14443360', '15117758']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8116693857877436
- 35 USC 102 Novelty (BERT): 0.660925307044619
- Combined Prediction Score: 0.7965949779134311
- Mean Citation Score: 555.0947259999998
- Max Citation Score: 750.12787
- Similarity Product: 608.5331650772284

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test