PATENT CLAIM ANALYSIS

Application Number: 16007829
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["435", "006120"]

Abstract:
The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.

Claim (Index 1):
A method for nucleic acid sequencing, comprising:\n (a) providing an array comprising a plurality of features in optical communication with a plurality of optical sensors, wherein said array is integrated with said plurality of optical sensors, wherein a feature of said plurality of features retains or immobilizes a plurality of nucleic acid molecules having sequences that are substantially identical to a nucleic acid sequence of a template nucleic acid molecule, and wherein an optical sensor of said plurality of optical sensors is in optical communication with said feature; (b) contacting said plurality of nucleic acid molecules with nucleic acid bases in the presence of flail polymerizing enzymes under conditions sufficient to incorporate said nucleic acid bases into flail growing strands complementary to said plurality of nucleic acid molecules, wherein said plurality of nucleic acid molecules is brought in contact with said nucleic acid bases without applying an electric field to confine or isolate said nucleic acid bases within said feature; (c) using said optical sensor to detect one or more signals from said plurality of nucleic acid molecules indicative of said nucleic acid bases incorporated into said growing strands; and (d) using said one or more signals detected in (c) to identify said nucleic acid bases, thereby generating a sequence corresponding to said nucleic acid sequence of said template nucleic acid molecule.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 94.0
- Lexical Diversity: 1.42
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16007969', '14119859', '13838816', '13481858', '13824129']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6220939135203104
- 35 USC 102 Novelty (BERT): 0.5959154731769902
- Combined Prediction Score: 0.6194760694859783
- Mean Citation Score: 358.6721080000001
- Max Citation Score: 453.87985
- Similarity Product: 371.6599934323937

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test