PATENT CLAIM ANALYSIS

Application Number: 16109562
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-08
Patent Classification: ["514", "290000"]

Abstract:
The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.

Claim (Index 1):
A method of treating anemia associated with chronic kidney disease, comprising administering to a mammalian patient in need thereof a therapeutically effective amount of a compound of formula ID: wherein q is zero or one; R 1  is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aminoacyl, aryl, substituted aryl, halo, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, and \u2014XR 6  where X is oxygen, \u2014S(O) n \u2014 or \u2014NR 7 \u2014 where n is zero, one or two, R 6  is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic, and R 7  is hydrogen, alkyl or aryl or, when X is \u2014NR 7 \u2014, then R 7  and R 6 , together with the nitrogen atom to which they are bound, can be joined to form a heterocyclic or substituted heterocyclic group; R 2  and R 3  are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, halo, hydroxy, cyano, \u2014S(O) n \u2014N(R 6 )\u2014R 6  where n is 0, 1, or 2, \u2014NR 6 C(O)NR 6 R 6 , and \u2014XR 6  where X is oxygen, \u2014S(O) n \u2014 or \u2014NR 7 \u2014 where n is zero, one or two, each R 6  is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic provided that when X is \u2014SO\u2014 or \u2014SO 2 \u2014, then R 6  is not hydrogen, and R 7  is selected from the group consisting of hydrogen, alkyl, and aryl, or R 2  and R 3  together with the carbon atoms pendent thereto, form an aryl, substituted aryl, heteroaryl, or substituted heteroaryl; R 4  and R 5  are independently selected from the group consisting of hydrogen, halo, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl and \u2014XR 6  where X is oxygen, \u2014S(O) n \u2014 or \u2014NR 7 \u2014 where n is zero, one or two, R 6  is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic, and R 7  is hydrogen, alkyl or aryl or, when X is \u2014NR\u2014, then R 7  and R 6 , together with the nitrogen atom to which they are bound, can be joined to form a heterocyclic or substituted heterocyclic group; R\u2033 is selected from the group consisting of hydrogen, alkyl and substituted alkyl; and R\u2032\u2033 is selected from the group consisting of hydroxy, alkoxy, substituted alkoxy, acyloxy, cycloalkoxy, substituted cycloalkoxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, aryl, and \u2014S(O) n \u2014R 10  wherein R 10  is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl and n is zero, one or two; or a pharmaceutically acceptable salt, ester, or amide derived from an amine of the formula HNR 20 R 21  where R 20  and R 21  are independently hydrogen, alkyl, substituted alkyl, aryl or substituted aryl, thereof; with the proviso that when R\u2033 is hydrogen and q is zero, then at least one of the following occurs: 1) R 1  is fluoro, bromo, iodo, alkyl, substituted alkyl, alkoxy, aminoacyl, substituted alkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, or \u2014XR 6  where X is oxygen, \u2014S(O) n \u2014 or \u2014NR 7 \u2014 where n is zero, one or two, R 6  is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic, and R 7  is hydrogen, alkyl or aryl; or 2) R 2  is substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, fluoro, bromo, iodo, cyano, or \u2014XR 6  where X is oxygen, \u2014S(O) n \u2014 or \u2014NR 7 \u2014 where n is zero, one or two, R 6  is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic, and R 7  is hydrogen, alkyl or aryl provided that: a) when R 2  is substituted alkyl such a substituent does not include trifluoromethyl; b) \u2014XR 6  is not alkoxy; and c) when \u2014XR 6  is substituted alkoxy such a substituent does not include benzyl or benzyl substituted by a substituent selected from the group consisting of (C 1 -C 5 ) alkyl and (C 1 -C 5 ) alkoxy or does not include a fluoroalkoxy substituent of the formula:\n \u2014O\u2014[CH 2 ] x \u2014C f H (2f+1\u2212g) F g  \n where x is zero or one; f is an integer of from 1 to 5; and g is an integer of from 1 to (2f+1); or 3) R 3  is substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, bromo, iodo, or \u2014XR 6  where X is oxygen, \u2014S(O) n \u2014 or \u2014NR 7 \u2014 where n is zero, one or two, R 6  is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic, and R 7  is hydrogen, alkyl or aryl provided that: a) when R 3  is substituted alkyl such a substituent does not include trifluoromethyl; b) \u2014XR 6  is not alkoxy; and c) when \u2014XR 6  is substituted alkoxy such a substituent does not include benzyl or benzyl substituted by a substituent selected from the group consisting of (C 1 -C 5 ) alkyl and (C 1 -C 5 ) alkoxy or does not include a fluoroalkoxy substituent of the formula:\n \u2014O\u2014[CH 2 ] x \u2014C f H (2f+1\u2212g) F g  \n where x is zero or one; f is an integer of from 1 to 5; and g is an integer of from 1 to (2f+1); or 4) R 4  is iodo, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, or \u2014XR 6  where X is oxygen, \u2014S(O) n \u2014 or \u2014NR 7 \u2014 where n is zero, one or two, R 6  is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic, and R 7  is hydrogen, alkyl or aryl provided that: a) when R 4  is substituted alkyl such a substituent does not include trifluoromethyl; b) \u2014XR 6  is not alkoxy; and c) when \u2014XR 6  is substituted alkoxy such a substituent does not include a fluoroalkoxy substituent of the formula:\n \u2014O\u2014[CH 2 ] x \u2014C f H (2f+1\u2212g) F g  \n where x is zero or one; f is an integer of from 1 to 5; and g is an integer of from 1 to (2f+1); or 5) R 5  is iodo, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, or \u2014XR 6  where X is oxygen, \u2014S(O) n \u2014 or \u2014NR 7 \u2014 where n is zero, one or two, R 6  is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic, and R 7  is hydrogen, alkyl or aryl provided that: a) when R 5  is substituted alkyl such a substituent does not include trifluoromethyl; b) \u2014XR 6  is not alkoxy; and c) when \u2014XR 6  is substituted alkoxy such a substituent does not include a fluoroalkoxy substituent of the formula:\n \u2014O\u2014[CH 2 ] x \u2014C f H (2f+1\u2212g) F g  \n where x is zero or one; f is an integer of from 1 to 5; and g is an integer of from 1 to (2f+1); and with the further following proviso: that when R 1 , R 3 , R 4 , and R 5  are hydrogen, then R 2  is not bromo and the compound is not N-((6-benzyloxy-1-chloro-4-hydroxy-isoquinolin-3-yl)-carbonyl-amino)-acetic acid or N-((7-benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino)-acetic acid.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 96.0
- Lexical Diversity: 1.16
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10861082', '15133104', '12015275', '11442727', '13599161']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8156201138973131
- 35 USC 102 Novelty (BERT): 0.6052052215614842
- Combined Prediction Score: 0.7945786246637303
- Mean Citation Score: 509.981424
- Max Citation Score: 539.677
- Similarity Product: 476.4088327754736

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test