PATENT CLAIM ANALYSIS

Application Number: 15955877
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-12
Patent Classification: ["546", "276400"]

Abstract:
Provided is a method for preparing a novel benzocoumarin-based two-photon absorbing fluorescent dye, such as a pyridinium-benzocoumarin (Py + BC) derivative compound and its precursor compound (pyridyl-benzocoumarin, PyBC), an aryl-benzocoumarin (ArBC) derivative compound, a benzothiazolyl-benzocoumarin (BtBC) derivative compound or a keto-benzocoumarin (KetoBC) derivative compound. The Py + BC derivative compound of the present invention is a two-photon absorbing near-infrared fluorescent dye, which may minimize interference of autofluorescence compared to conventional two-photon absorbing fluorescent dyes such as acedan and naphthalimide, thereby obtaining a high-definition image, and therefore is expected to be effectively used in imaging studies. In addition, when the two-photon absorbing near-infrared fluorescent dye of the present invention is used, it is expected to be suitable for high resolution imaging of deep tissue.

Claim (Index 1):
A pyridinium-benzocoumarin (Py + BC) derivative compound represented by Formula 1 and its precursor, a pyridinyl-benzocoumarin (PyBC) derivative compound, an aryl-benzocoumarin (ArBC) derivative compound represented by Formula 2, a benzothiazolyl-benzocoumarin (BtBC) derivative compound represented by Formula 3, a keto-benzocoumarin (ketoBC) derivative compound represented by Formula 4, or a pharmaceutically acceptable salt thereof: where R 1  and R 2  are each independently hydrogen (H), a methyl group (Me), an allyl group, or a C 2 -C 12  unsubstituted alkyl group; R 1  is linked to R 2  in a ring;\n R 3  is hydrogen (H), or \n linked to R 2  in a ring; and\n R 4  is hydrogen (H), a methyl (Me) group, or oxygen (O). \n where R 1  and R 2  are each independently hydrogen (H), a methyl group (Me), an allyl group, or a C 2 -C 12  unsubstituted alkyl group; R 1  is linked to R 2  in a ring;\n R 3  is hydrogen (H), or \n linked to R 2  in a ring; and\n R 4  is a hydroxyl group (OH), an amine group (NH 2 ), a nitro group (NO 2 ), an acetate group (OCOMe), or a carboxyl group (COOH). \n where R 1  and R 2  are each independently hydrogen (H), a methyl group (Me), an allyl group, or a C 2 -C 12  unsubstituted alkyl group; R 1  is linked to R 2  in a ring;\n R 3  is hydrogen (H), or \n linked to R 2  in a ring; and\n R 4  is a hydroxyl group (OH), an amine group (NH 2 ), a nitro group (NO 2 ), or a carboxyl group (COOH). \n where R 1  and R 2  are each independently hydrogen (H), a methyl group (Me), an allyl group, or a C 2 -C 12  unsubstituted alkyl group; R 1  is linked to R 2  in a ring;\n R 3  is hydrogen (H), or \n linked to R 2  in a ring;\n R 4  is hydrogen (H), a methyl group (Me), an acetoxy group (COMe), or \n and\n R 5  is hydrogen (H), a hydroxyl group (OH), an amine group (NH 2 ), or a nitro group (NO 2 ).

Metadata:
- Claim Count in Document: 7.0
- Percentile: 91.0
- Lexical Diversity: 1.93333
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14745973', '11628019', '11658533', '12596685', '13055830']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7922049971354427
- 35 USC 102 Novelty (BERT): 0.5319785271180513
- Combined Prediction Score: 0.7661823501337035
- Mean Citation Score: 283.23887
- Max Citation Score: 367.9268
- Similarity Product: 269.3680737082482

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test