PATENT CLAIM ANALYSIS

Application Number: 16171837
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-07
Patent Classification: ["514", "017700"]

Abstract:
Provided are methods and compositions for maintaining the viability of photoreceptor cells and/or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (AMD) (e.g., dry or neovascular AMD), retinitis pigmentosa (RP), or a retinal detachment. The viability of the photoreceptor cells and/or the retinal pigment epithelial cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

Claim (Index 71):
The composition of  claim 57 , wherein the necrosis inhibitor is a Nec-4 related compound of Formula IV: or a pharmaceutically acceptable salt, ester, or prodrug thereof, wherein:\n R 1  is \n R 2  and R 3  each represent independently for each occurrence hydrogen or methyl; R 4  represents independently for each occurrence halogen, hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 4 alkynyl; R 5  is C 1 -C 4 alkyl; R 6  is hydrogen, halogen, or \u2014CN; R 7  is hydrogen or C 1 -C 4 alkyl; R 8  is C 1 -C 6 alkyl, or R 8  taken together with R 9 , when present, forms a carbocyclic ring; R 9  is hydrogen or C 1 -C 6 alkyl, or R 9  taken together with R 8  forms a carbocyclic ring; R 10  is hydrogen or C 1 -C 6 alkyl; A is phenylene or a 5-6 membered heteroarylene; X is N or \u2014C(R 9 )\u2014; Y is N or \u2014C(R 10 )\u2014; Z is S or O; and m and n each represent independently 1, 2, or 3.

Metadata:
- Claim Count in Document: 158.0
- Percentile: 97.0
- Lexical Diversity: 1.83582
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14934810', '15288214', '15956133', '15093480', '12086792']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8364244563476255
- 35 USC 102 Novelty (BERT): 0.7604355546556453
- Combined Prediction Score: 0.8288255661784275
- Mean Citation Score: 705.1886999999997
- Max Citation Score: 903.4753
- Similarity Product: 864.6203309227764

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test