PATENT CLAIM ANALYSIS

Application Number: 16330474
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["562", "557000"]

Abstract:
The present invention discloses an amino mercaptan compound, preparation method thereof and use thereof in radiation protection. The compound has the structure of formula I, wherein A 1  is selected from: —C(O)NR 8 —, —S(O) 2 —NR 8 —, —S(O)NR 8 —, and —R 7 —NR 8 —; A 2  is selected from: carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted C 1-6  alkyl; R 1 , R 2 , R 5 , and R 6  may be the same or different and are selected from: hydrogen, substituted or unsubstituted C 1 -C 5  alkyl or heteroalkyl; n is an integer from 0 to 20,000; R 3  and R 4  are independently selected from: hydrogen, X, substituted or unsubstituted C 1-6  alkyl; X is selected from: F, Cl, Br and I; R 7  is selected from: substituted or unsubstituted C 1 -C 6  alkyl; and R 8  is selected from: hydrogen, substituted or unsubstituted C 1 -C 6  alkyl. The compound has the effects of reducing the biological damage caused by ionizing radiation, extending the survival period and survival rate of the radiated animals, and significantly alleviating the side effects of radiotherapy, and has a low toxicity. The present invention opens up a new way for protection and treatment of ionizing radiation damage.

Claim (Index 1):
A compound of formula (I) wherein A 1  is selected from: \u2014C(O)NR 8 \u2014, \u2014S(O) 2 \u2014NR 8 \u2014, \u2014S(O)NR 8 \u2014, and \u2014R 7 \u2014NR 8 \u2014; A 2  is selected from: carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted C 1 -C 6  alkyl; R 1 , R 2 , R 5 , and R 6  may be the same or different and are selected from: hydrogen, substituted or unsubstituted C 1 -C 5  alkyl or heteroalkyl; n is an integer from 0 to 20,000; R 3  and R 4  are independently selected from: hydrogen, X, substituted or unsubstituted C 1-6  alkyl; X is selected from: F, Cl, Br and I; and R 7  is selected from: substituted or unsubstituted C 1 -C 6  alkyl; R 8  is selected from: hydrogen, substituted or unsubstituted C 1 -C 6  alkyl; and stereoisomers thereof or pharmaceutically acceptable salts, prodrugs and solvates thereof.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 99.0
- Lexical Diversity: 2.51961
- Patent Class: 562.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14783447', '15522969', '13640188', '13294677', '16156289']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7554986391008089
- 35 USC 102 Novelty (BERT): 0.5173165887651849
- Combined Prediction Score: 0.7316804340672466
- Mean Citation Score: 288.715722
- Max Citation Score: 294.67108
- Similarity Product: 214.8764364553737

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test