PATENT CLAIM ANALYSIS

Application Number: 16235068
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["546", "085000"]

Abstract:
Provided herein are improved processes for the synthesis of substituted tetrahydro beta-carboline derivatives. In particular, provided herein are improved processes useful for the preparation of (S)-4-chlorophenyl 6-chloro-1-(4-methoxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate. Formula (I):

Claim (Index 17):
A process for preparing a compound of Formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof: comprising the steps of:\n i) reacting about one equivalent of a compound of Formula (IV), with about 0.5 equivalents of a chiral acid in a first solvent mixture of water and absolute ethanol, wherein said absolute ethanol has about 0% water, and about 2% to about 5% by volume of water is added to said absolute ethanol: \n to provide a compound of Formula (II), wherein X is halogen; and R is substituted or unsubstituted C 1  to C 8  alkyl; and ii) reacting the compound of Formula (II) with a compound of Formula (III) in the presence of a base and a second solvent mixture comprising water and a solvent: to provide a compound of Formula (I), wherein X is at each occurrence independently halogen; and R is substituted or unsubstituted C 1  to C 8  alkyl.

Metadata:
- Claim Count in Document: 42.0
- Percentile: 98.0
- Lexical Diversity: 1.38889
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13541504', '13806378', '13940421', '15807877', '12578934']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7410080857881974
- 35 USC 102 Novelty (BERT): 0.478248605919191
- Combined Prediction Score: 0.7147321378012969
- Mean Citation Score: 197.166682
- Max Citation Score: 206.0179
- Similarity Product: 161.68753730201124

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test