PATENT CLAIM ANALYSIS

Application Number: 16219589
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["514", "210180"]

Abstract:
The subject matter generally relates to methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) as neuroprotective agents and/or neural regenerative agents. In a further aspect, the subject matter relates to individuals that are at risk for the development of CNS disease or disorder.

Claim (Index 12):
A method of  claim 1 , wherein the PDE1 inhibitor is compound of Formula XI: wherein\n (i) L is S, SO or SO 2 ; \n (ii) R 2  is H or C 1-6 alkyl (e.g., methyl or ethyl); \n (iii) R 2  is \n H, \n C 1-6 alkyl (e.g., isopropyl, isobutyl, neopentyl, 2-methylbutyl, 2,2-dimethylpropyl) wherein said alkyl group is optionally substituted with halo (e.g., fluoro) or hydroxy (e.g., 1-hydroxypropan-2-yl, 3-hydroxy-2-methylpropyl), \u2014C 0-4 alkyl-C 3-8 cycloalkyl (e.g., cyclopentyl, cyclohexyl) optionally substituted with one or more amino (e.g., \u2014NH 2 ), for example, 2-aminocyclopentyl or 2-aminocyclohexyl), wherein said cycloalkyl optionally contains one or more heteroatom selected from N and O and is optionally substituted with C 1-6 alkyl (e.g., 1-methyl-pyrrolindin-2-yl, 1-methyl-pyrrolindin-3-yl, 1-methyl-pyrrolindin-2-yl-methyl or 1-methyl-pyrrolindin-3-yl-methyl), C 3-8 heterocycloalkyl (e.g., pyrrolidinyl, for example, pyrrolidin-3-yl) optionally substituted with C 1-6 alkyl (e.g., methyl), for example, 1-methylpyrrolidin-3-yl, C 3-8 cycloalkyl-C 1-6 alkyl (e.g., cyclopropylmethyl), haloC 1-6 alkyl (e.g., trifluoromethyl, 2,2,2-trifluoroethyl), \u2014N(R 14 )(R 15 )\u2014C 1-6 alkyl (e.g., 2-(dimethylamino)ethyl, 2-aminopropyl), hydroxyC 1-6 alkyl (e.g., (e.g., 3-hydroxy-2-methylpropyl, 1-hydroxyprop-2-yl), arylC 0-6 alkyl (e.g., benzyl), heteroarylC 1  6alkyl (e.g., pyridinylmethyl), C 1-6 alkoxyarylC 1-6 alkyl (e.g., 4-methoxybenzyl); -G-J wherein: G is a single bond or, alkylene (e.g., methylene); \n J is cycloalkyl or heterocycloalkyl (e.g., oxetan-2-yl, pyrolyin-3-yl, pyrolyin-2-yl) optionally substituted with C 1-6 alkyl (e.g., (1-methylpyrolidin-2-yl)); \n (iv) R 3  is attached to one of the nitrogens on the pyrazolo portion of Formula I and is a moiety of Formula A \n wherein X, Y and Z are, independently, N or C, and R 8 , R 9 , R 11  and R 12  are independently H or halogen (e.g., Cl or F); and R 10  is halogen, C 1-6 alkyl, C 3-8 cycloalkyl, heteroC 3-8 cycloalkyl (e.g., pyrrolidinyl or piperidinyl) haloC 1-6 alkyl (e.g., trifluoromethyl), aryl (e.g., phenyl), heteroaryl (e.g., pyridyl, (for example, pyrid-2-yl) or e.g., thiadiazolyl (for example, 1,2,3-thiadiazol-4-15 yl), diazolyl, triazolyl (e.g., 1,2,4-triazol-1-yl), tetrazolyl (e.g., tetrazol-5-yl), alkoxadiazolyl (e.g., 5-methyl-1,2,4-oxadiazol), pyrazolyl (e.g., pyrazol-1-yl), alkyl sulfonyl (e.g., methyl sulfonyl), arylcarbonyl (e.g., benzoyl), or heteroarylcarbonyl, alkoxycarbonyl, (e.g., methoxycarbonyl), aminocarbonyl; preferably phenyl, pyridyl, e.g., 2-pyridyl, piperidinyl, or pyrrolidinyl; wherein the aryl, heteroaryl cycloalkyl or heterocycloalkyl is optionally substituted with one or more halo (e.g., F or Cl), C 1-6 alkly, C 1-6 alkoxy, C 1-4 haloalkyl (e.g., trifluoromethyl), and/or \u2014SH, provided that when X, Y or X is nitrogen, R 8 , R 9  or R 10 , respectively, is not present; (v) R 4  is H, C 1-6 alkyl (e.g., methyl, isopropyl), C 3-8 cycloalkyl (e.g., cyclopentyl), C 3-8 heterocycloalkyl (e.g., pyrrolidin-3-yl), aryl (e.g., phenyl) or heteroaryl (e.g., pyrid-4-yl, pyrid-2-yl or pyrazol-3-yl) wherein said aryl or heteroaryl is optionally substituted with halo (e.g., 4-fluorophenyl), hydroxy (e.g., 4-hydroxyphenyl), C 1-6 alkyl, C 1-6 alkoxy or another aryl group (e.g., biphenyl-4-ylmethyl); (vi) R 14  and R 15  are independently H or C 1-6 alkyl, in free or salt form.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 98.0
- Lexical Diversity: 1.54545
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14777448', '15406346', '14767489', '15709258', '14820323']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7831299022225667
- 35 USC 102 Novelty (BERT): 0.5516881495211082
- Combined Prediction Score: 0.7599857269524208
- Mean Citation Score: 348.187806
- Max Citation Score: 492.94012
- Similarity Product: 371.0175625318194

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test