PATENT CLAIM ANALYSIS

Application Number: 16291264
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-09
Patent Classification: ["435", "007210"]

Abstract:
Methods of measuring the amount of singly- or multiply-phosphorylated p217+ tau protein in a sample are provided. Methods of detecting or diagnosing tauopathies, methods of determining the effectiveness of a treatment of a tauopathy, and methods of determining whether a subject is suitable for anti-p217+ tau antibody therapy are also provided. Also described are antibodies for use in the methods and kits comprising the antibodies.

Claim (Index 4):
A method of measuring p217+ tau peptides in a sample:\n (i) contacting the sample with a capture antibody directed against a p217+ tau epitope to capture p217+ tau peptides in the sample, and contacting the sample with a phosphorylation-independent capture antibody directed against an epitope between amino acids 150 and 250 of tau protein, preferably an epitope comprising amino acids 159-163 of tau protein, to capture total tau peptides in the sample; (ii) conducting at least one of:\n a. contacting the captured p217+ tau peptides with a first detection antibody directed against an epitope comprising amino acid residues 119 to 126 of tau protein to thereby measure an amount of p217+ tau peptides, contacting the captured total tau peptides with the first detection antibody to thereby measure an amount of total tau peptides, and determining a ratio of the amount of p217+ tau peptides to the amount of total tau peptides; and \n b. contacting the captured p217+ tau peptides with a second detection antibody directed against an epitope comprising amino acid residues 7 to 20 of tau protein to thereby measure an amount of long p217+ tau peptides, and contacting the captured total tau peptides with the second detection antibody to thereby measure an amount of total long tau peptides, and determining a ratio of the amount of long p217+ tau peptides to the amount of total long tau peptides, \n wherein the numbering of the amino acid is with reference to the amino acid sequence set forth in SEQ ID NO: 1.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 99.0
- Lexical Diversity: 1.66667
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15337964', '15750982', '16291303', '14348918', '14154954']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.597145318614707
- 35 USC 102 Novelty (BERT): 0.532587994166685
- Combined Prediction Score: 0.5906895861699049
- Mean Citation Score: 343.305048
- Max Citation Score: 355.36682
- Similarity Product: 238.81378626090648

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test