PATENT CLAIM ANALYSIS

Application Number: 16079764
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "233200"]

Abstract:
The present disclosure relates to novel crystalline form I, form II and form III of 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]imidazo [1,2-a]pyrazin-8-amine mesylate, and preparation methods and use thereof. Crystalline form I is a dimesylate, and its X-ray powder diffraction pattern shows characteristic peaks at 2theta values of 5.9°±0.2°, 13.5°±0.2° and 21.8°±0.2°. Crystalline form II is a dimesylate, and its X-ray powder diffraction pattern shows characteristic peaks at 2theta values of 15.8°±±0.2°, 17.2°±0.2° and 19.5°±0.2°. Crystalline form III is a monomesylate, and its X-ray powder diffraction pattern shows characteristic peaks at 2theta values of 7.4°±0.2°, 12.9°±0.2° and 19.2°±0.2°. The crystalline forms are more suitable for drug development than prior crystalline forms, and the preparation methods for the crystalline forms are simple and repeatable and have significant value for future drug optimization and development.

Claim (Index 23):
The preparation method of crystalline form III according to  claim 19 , wherein, in step a), said stirring is at 5-50\u00b0 C.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 96.0
- Lexical Diversity: 2.09333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15563344', '16304280', '15542597', '15535104', '16065350']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8086600188836113
- 35 USC 102 Novelty (BERT): 0.5587051457377916
- Combined Prediction Score: 0.7836645315690293
- Mean Citation Score: 424.731488
- Max Citation Score: 436.65366
- Similarity Product: 304.1257620583392

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test