PATENT CLAIM ANALYSIS

Application Number: 16016053
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "242000"]

Abstract:
This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein R A  is, for example, a group of the following formula (A-1): wherein ring A 1  is, for example, a cycloalkyl group which may be substituted,and R B  is, for example, a monocyclic cycloalkyl group, or a pharmaceutically acceptable salt thereof.

Claim (Index 5):
The method according to  claim 3 ,\n wherein\n R A  is \n (1) a phenyl group which may be substituted with 1-3 groups selected independently from the group consisting of a halogen atom, an alkyl group, and a haloalkyl group, \n R B  is a group of the above formula (B-4): \n wherein X a  represents N, \n X b  represents CH 2 , and X c  represents NH, or \n X b  represents NH, and X c  represents CH 2 , \n R B6  represents a hydrogen atom, \n R B7  is \n (i) a cyclohexyl group which may be substituted, wherein a substituent of the cyclohexyl group is 1-2 groups selected independently from the group consisting of a piperidinyl group which may be substituted with a hydroxyl group; an amino group which may be substituted with 1-2 groups selected independently from the group consisting of an alkyl group and an alkanoyl group; and an alkoxy group which may be substituted with a carbamoyl group which may be substituted with 1-2 alkyl groups, \n (ii) an aliphatic heterocyclic group which may be substituted (wherein the aliphatic heterocyclic group is selected from an azetidinyl group, a tetrahydrofuranyl group, a pyrrolidinyl group, a tetrahydropyranyl group, a piperidinyl group, a tetrahydrothiopyranyl group, or 3-methylenedioxy group which may be substituted with 1-2 halogen atoms, \n (2) a naphthyl group which may be substituted with an alkyl group, or \n (3) a tetrahydronaphthyl group, \n R B7  is \n (i) a cycloalkyl group which may be substituted (wherein the cycloalkyl group is a cyclopentyl group, a cyclohexyl group, a bicyclo[2.2.2]octyl group, or an adamantyl group), wherein a substituent of the cycloalkyl group is 1-2 groups selected independently from the group consisting of a hydroxyl group; an aliphatic heterocyclic group which may be substituted with 1-2 groups selected independently from the group consisting of a hydroxyl group and an oxo group (wherein the aliphatic heterocyclic group is selected from a thiomorpholinyl group, a piperidinyl group, a piperazinyl group, or a morpholinyl group); an amino group which may be substituted with 1-2 groups selected independently from the group consisting of an alkyl group and an alkanoyl group; an alkyl group which may be substituted with a hydroxyl group; an alkoxy group which may be substituted with a carbamoyl group which may be substituted with 1-2 alkyl groups; and an alkylsulfonyl group, \n (ii) an aliphatic heterocyclic group which may be substituted (wherein the aliphatic heterocyclic group is selected from an azetidinyl group, a tetrahydrofuranyl group, a pyrrolidinyl group, a tetrahydropyranyl group, a piperidinyl group, a tetrahydrothiopyranyl group, or 3-oxabicyclo[3.3.1]nonyl), wherein a substituent of the aliphatic heterocyclic group is 1-3 groups selected independently from the group consisting of a halogen atom; a hydroxyl group; an oxo group; an alkyl group which may be substituted with 1-3 groups selected independently from the group consisting of a hydroxyl group, a cycloalkyl group which may be substituted with a hydroxyl group, an alkoxy group, an alkylsulfonyl group, an alkylsulfonylamino group, a carbamoyl group which may be substituted with 1-2 alkyl groups, morpholinylcarbonyl group, and a heteroaryl group which may be substituted with an alkyl group and may oxabicyclo[3.3.1]nonyl), wherein a substituent of the aliphatic heterocyclic group is 1-3 groups selected independently from the group consisting of a hydroxyl group; an alkyl group which may be substituted with 1-3 groups selected independently from the group consisting of an amino group which may be substituted with an alkylsulfonyl group, a carbamoyl group which may be substituted with 1-2 alkyl groups, an imidazolinyl group which may be substituted with an alkyl group; an alkanoyl group which may be substituted with a hydroxyl group; and a cycloalkylcarbonyl group which may be substituted with a hydroxyl group, or \n (iii) a pyrazolyl group which may be substituted with an alkyl group which may be substituted with a carbamoyl group which may be substituted with 1-2 alkyl groups.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 94.0
- Lexical Diversity: 1.76056
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15305587', '15313407', '13201536', '11363563', '14619980']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8174727716576999
- 35 USC 102 Novelty (BERT): 0.5876499097761032
- Combined Prediction Score: 0.7944904854695403
- Mean Citation Score: 313.52282600000007
- Max Citation Score: 484.2341
- Similarity Product: 474.8333775097728

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test