PATENT CLAIM ANALYSIS

Application Number: 16087413
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-02
Patent Classification: ["514", "369000"]

Abstract:
The present invention relates to the technical field of medicine, and specifically relates to a PUMA inhibitor, a method for preparation thereof, and a use thereof. The PUMA inhibitor is the compound as shown in (I) or a pharmaceutically acceptable salt thereof. The definitions of its substituent groups are as described in the description. The compound (I) or pharmaceutically acceptable salt thereof is capable of targeting a PUMA protein and has very good physicochemical properties, very good apoptosis resistance and radiation protection effects; it can selectively inhibit the competitive combined effect of a PUMA protein and a Bcl-2 apoptosis-resistant protein, block apoptosis, and effectively protects against bone marrow damage. The present invention provides a new idea for, and powerful proof of, the application of a PUMA-protein small molecule inhibitor in radiation-protection pharmaceuticals, and is likely to become a highly effective, low-toxicity, and stable clinical radiation-protection pharmaceutical.

Claim (Index 8):
The method according to  claim 7 , wherein the disease is associated with radiation-induced damage or apoptosis.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 97.0
- Lexical Diversity: 1.85556
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14914307', '15310142', '15122890', '14912082', '13356763']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7429460807022544
- 35 USC 102 Novelty (BERT): 0.535557580161408
- Combined Prediction Score: 0.7222072306481697
- Mean Citation Score: 259.619644
- Max Citation Score: 269.09222
- Similarity Product: 123.33200412274245

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test