PATENT CLAIM ANALYSIS

Application Number: 15975418
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "497000"]

Abstract:
Provided is a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol encapsulated in a biodegradable polymer to control the release of the oxysterol. Methods of making and use are further provided.

Claim (Index 21):
A method of treating a bone defect site, the method comprising: implanting an implant at the bone defect site, the implant comprising a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol comprising (3S,5S,6S,8R,9S,10R,13S,14S,17S) 17-((S)-2-hydroxyoctan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol (Oxy133) monohydrate encapsulated in a biodegradable polymer to control the release of the oxysterol, wherein the biodegradable polymer is in the form of microspheres disposed within a biodegradable matrix, the oxysterol is in an amount of about 5 wt % to about 30 wt % of the biodegradable matrix, the biodegradable matrix further comprises mineral particles in an amount of about 54 wt % to about 80 wt % of the biodegradable matrix, and the mineral particles comprise tricalcium phosphate and hydroxyapatite in a ratio of about 85:15, wherein the composition comprises carboxymethyl cellulose (CMC) in an amount of from about 2 wt % to about 4 wt % of the composition, and the biodegradable matrix comprises collagen in an amount of from about 12 wt % to about 13 wt % of the biodegradable matrix.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 93.0
- Lexical Diversity: 1.36667
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14796625', '14796601', '14741673', '15879761', '14924170']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.82665213708673
- 35 USC 102 Novelty (BERT): 0.6431031492815577
- Combined Prediction Score: 0.8082972383062128
- Mean Citation Score: 592.611352
- Max Citation Score: 660.79926
- Similarity Product: 579.9207090623187

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test