PATENT CLAIM ANALYSIS

Application Number: 15754292
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "215000"]

Abstract:
The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention, or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.

Claim (Index 1):
A compound of the Formula (I) wherein; ---- is absent or a single bond;\n X is selected from \u2014O\u2014, \u2014N\u2014, or \u2014S\u2014; \n n is 0-6; \n R 1  is selected from the group consisting of hydrogen, halogen, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, C 3-8  cycloalkyl, C 5-6  aryl, C 1-6  heteroaryl, C 1-6  alkoxyalkyl with heteroatoms selected from N, O, S;\n wherein C 1-6  alkyl, C 3-8  cycloalkyl, C 5-6  aryl, C 1-6  heteroaryl, is optionally substituted with one or more of the groups selected from hydrogen, C 1-6  alkyl, halogen, OH; \n R 2  and R 3  are independently selected from hydrogen, halogen, hydroxy, nitro, cyano, azido, nitroso, oxo (\u2550O), thioxo (\u2550S), \u2014SO 2 \u2014, amino, hydrazino, formyl, C 1-6  alkyl, haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy; arylalkoxy; C 3-8  cycloalkyl, C 3-8  cycloalkyloxy, C 5-6  aryl, C 2-6  heterocyclyl, C 1-6  heteroaryl, alkylamino, \u2014COOR a , \u2014C(O)R b , \u2014C(S)R a , \u2014C(O)NR a R b , \u2014C(S)NR a R b , \u2014NR a C(O)NR b R c , NR a C(S)NR b R c , \u2014N(R a )SOR b , \u2014N(R a )SO 2 R b , \u2014NR a C(O)OR b , \u2014NR a R b , \u2014NR a C(O)R b \u2014, NR a C(S)R b \u2014, \u2014SONR a R b \u2014, \u2014SO 2 NR a R b \u2014, \u2014OR a , \u2014OR a C(O)OR b \u2014, \u2014OC(O)NR a R b , OC(O)R a , \u2014OC(O)NR a R b \u2014, \u2014R a NR b R c , \u2014R a OR b \u2014, \u2014SR a , \u2014SOR a  or \u2014SO 2 R a , wherein R a , R b  and R c  are independently selected from hydrogen, C 1-6  alkyl, C 3-8  cycloalkyl, C 5-6  aryl, C 5-6  arylalkyl, C 2-6  heterocyclyl, C 1-6  heteroaryl or C 2-6  heteroarylalkyl; R 4  is selected from the group consisting of hydrogen, C 1-6  alkyl, C 1-6  haloalkyl, C 3-8  cycloalkyl, C 5-6  aryl, C 1-6  heteroaryl, C 1-6  alkoxyalkyl with heteroatoms selected from N, O, S;\n wherein C 1-6  alkyl, C 3-8  cycloalkyl, C 5-6  aryl, C 2-6  heteroaryl, is optionally substituted with one or more of the groups selected from hydrogen, C 1-6  alkyl, C 3-8  cycloalkyl, halogen, OH and cyano; \n ring A is selected from the group consisting of C 1-6  heteroaryl, C 3-8  cycloalkyl, C 3-10  cycloaryl, C 4-6  heterocycloalkyl, and C 4-10  heterocycloaryl with heteroatoms selected from N, O, S; \n Z is selected from \u2014CH 2 OR 5 , \u2014COOR 5  or \u2014CONR 5 R 6 , \u2014NR 5 R 6 , \u2014NR 5 CO\u2014OR 6 , \n NR 5 CO\u2014NR 6 R 7 , \u2014NR 5 COR 6 , \u2014NSO 2 R 6  or \u2014O\u2014CO\u2014NR 5 R 6 ; \n R 5 , R 6  and R 7  are independently selected from hydrogen or substituted or unsubstituted C 5-6  aryl, C 1-6  heteroaryl, C 3-8  cycloalkyl and C 1-6  alkyl; \n wherein when, R 5 , R 6  and R 7  are substituted, the one or more substituents are selected from hydrogen, halogen, hydroxy, nitro, cyano, azido, nitroso, oxo (\u2550O), thioxo (\u2550S), \u2014SO 2 \u2014, amino, hydrazino, formyl, C 1-6  alkyl, haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy; C 5-6  arylalkoxy, C 3-8  cycloalkyl, C 3-8  cycloalkyloxy, C 5-6  aryl, C 2-6  heterocyclyl, C 1-6  heteroaryl, alkylamino, \u2014COOR a , \u2014C(O)R b , \u2014C(S)R a , \u2014C(O)NR a R b , \u2014C(S)NR a R b , \u2014NR a C(O)NR b R c , NR a C(S)NR b R c , \u2014N(R a )SOR b , \u2014N(R a )SO 2 R b , \u2014NR a C(O)OR b , \u2014NR a R b , \u2014NR a C(O)R b \u2014, NR a C(S)R b \u2014, \u2014SONR a R b \u2014, \u2014SO 2 NR a R b \u2014, \u2014OR a , \u2014OR a C(O)OR b \u2014, \u2014OC(O)NR a R b , OC(O)R a , \u2014OC(O)NR a R b \u2014, \u2014R a NR b R c , \u2014R a OR b \u2014, \u2014SR a , \u2014SOR a  or \u2014SO 2 R a , wherein R a , R b  and R c  are independently selected from hydrogen, C 1-6  alkyl, C 3-8  cycloalkyl, C 5-6  aryl, C 5-6  arylalkyl, C 2-6  heterocyclyl, C 1-6  heteroaryl or C 1-6  heteroarylalkyl.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 88.0
- Lexical Diversity: 1.62121
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15562381', '13211678', '10288980', '14546896', '13309646']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8072330081774387
- 35 USC 102 Novelty (BERT): 0.5738721203531237
- Combined Prediction Score: 0.7838969193950073
- Mean Citation Score: 365.917208
- Max Citation Score: 490.91003
- Similarity Product: 356.59892717307923

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test