PATENT CLAIM ANALYSIS

Application Number: 15745496
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "007100"]

Abstract:
Aspects of the disclosure relate to compositions of enzyme-binding polypeptides (EBPs) that modify the substrate specificity of an enzyme and a method for identifying an EBP that modifies substrate specificity of an enzyme binding at least one substrate, the method comprising: contacting the enzyme with a polypeptide library comprising a plurality of EBPs that bind different epitopes of the enzyme; identifying EBPs that bind to the enzyme to form an EBP-enzyme complex; assaying for the activity level and substrate specificity of the EBP-enzyme complex; and identifying EBPs that modify the substrate specificity of the enzyme by identifying EBPs that, when in an EBP-enzyme complex, have a different substrate specificity than un-complexed EBP; wherein the catalytic rate constant of the EBP-enzyme complex is ≥50% of the un-complexed enzyme for at least one substrate and/or wherein the EBP-enzyme complex retains binding to a substrate.

Claim (Index 27):
The method of  claim 26 , wherein one or more of the variant amino acids corresponds to position 30, 31, 33, 49, 47, 75, 76, 84, and/or 85 of SEQ ID NO:91.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 86.0
- Lexical Diversity: 2.44444
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13813409', '10006760', '13555379', '11848135', '10190162']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.627224274044422
- 35 USC 102 Novelty (BERT): 0.5264596536097028
- Combined Prediction Score: 0.6171478120009501
- Mean Citation Score: 307.33611200000007
- Max Citation Score: 348.3478
- Similarity Product: 237.4418246916056

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test