PATENT CLAIM ANALYSIS

Application Number: 15996373
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-11
Patent Classification: ["800", "008000"]

Abstract:
A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.

Claim (Index 21):
A transgenic chicken that comprises a genome comprising a recombinant immunoglobulin light chain (IgL) locus comprising:\n a) a functional IgL gene comprising a nucleic acid encoding a light chain variable region comprising:\n i) light chain CDR1, CDR2 and CDR3 regions; and \n ii) a light chain framework; and, \n b) a plurality of pseudogenes that encode light chain variable regions each comprising:\n i) light chain CDR1, CDR2 and CDR3 regions; and \n ii) a light chain framework region that is identical in amino acid sequence to the light chain framework of a) (ii); \n wherein said recombinant IgL locus comprises, in operable linkage: an intron region, a constant domain region-encoding region and a 3\u2032 untranslated region; wherein at least part of said intron region is endogenous to the genome of said transgenic chicken; and said nucleic acid of a) and pseudogene of b), are exogenous to the genome of said transgenic chicken, wherein said plurality of pseudogenes are operably linked to said functional IgL gene and donate nucleotide sequences to the nucleic acid of a) by gene conversion in said transgenic chicken; and wherein said transgenic chicken expresses a polyclonal antisera comprising a diversified IgL variable region.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 94.0
- Lexical Diversity: 2.45
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14057820', '15188724', '12854722', '15377940', '15967271']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6491090774009823
- 35 USC 102 Novelty (BERT): 0.5900483732220454
- Combined Prediction Score: 0.6432030069830886
- Mean Citation Score: 444.043014
- Max Citation Score: 477.1717
- Similarity Product: 465.586022446388

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test