PATENT CLAIM ANALYSIS

Application Number: 15969537
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-03
Patent Classification: ["514", "152000"]

Abstract:
The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein:\n X is selected from hydrogen, bromo, fluoro, chloro, C 1 -C 6  alkyl, \u2014O\u2014C 1 -C 6  alkyl, \u2014S(O) m \u2014C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, \u2014O\u2014C 3 -C 7  cycloalkyl, \u2014S(O) m \u2014C 3 -C 7  cycloalkyl, \u2014CN, \u2014N(R 4 )(R 5 ), and \u2014NH\u2014C(O)\u2014(C 1 -C 6  alkylene)-N(R 4 )(R 5 ), wherein each alkyl, alkylene or cycloalkyl in the group represented by X is optionally substituted with fluoro; \n Y is selected from fluoro, \u2014C 1 -C 6  alkyl and \u2014[C(R 1a )(R 1b )] m \u2014N(R 2 )(R 2 )(R 3 ); \n Z is selected from hydrogen, fluoro, \n bromo, \u2014CN, \u2014[C(R 1a )(R 1b )] n \u2014N(R 2 )(R 3 ), \u2014N(R 4 )(R 5 ), NO 2 , \u2014NH\u2014C(O)\u2014(C 1 -C 4  alkylene)-N(R 4 )(R 5 ), C 1 -C 6  alkyl, \u2014NH\u2014C(O)\u2014C 1 -C 6  alkyl, \u2014NH\u2014S(O) m \u2014C 1 -C 6  alkyl, \u2014NH\u2014S(O) m \u2014C 3 -C 10  carbocyclyl, \u2014NH\u2014S(O) m -(4-13 membered) heterocyclyl; each R 1a  and R 1b  is independently selected from hydrogen, C 1 -C 4  alkyl, and C 3 -C 10  carbocyclyl;\n R 2  is selected from hydrogen, C 1 -C 12  alkyl, \u2014C 0 -C 6  alkylene-C 3 -C 10  carbocyclyl, and \u2014C 0 -C 6  alkylene-(4-13 membered) heterocyclyl; \n R 3  is selected from hydrogen, C 1 -C 8  alkyl, \u2014C 0 -C 6  alkylene-C 3 -C 10  carbocyclyl, \u2014C 0 -C 6  alkylene-(4-13 membered) heterocyclyl, \u2014C(O)\u2014C 1 -C 6  alkyl, \u2014C 0 -C 6  alkylene-C(O)N(R 4 )(R 5 ), \u2014C(O)\u2014C 1 -C 6  alkylene-N(R 4 )(R 5 ), \u2014C 2 -C 6  alkylene-N(R 4 )(R 5 ), \u2014S(O) m \u2014C 1 -C 6  alkyl, \u2014S(O) m \u2014C 3 -C 10  carbocyclyl, and \u2014S(O) m -(4-13 membered) heterocyclyl, wherein each alkyl, carbocyclyl, alkylene or heterocyclyl in the group represented by R 2  or R 3  is optionally and independently substituted with one or more substituents independently selected from fluoro, chloro, \u2014OH, \u2014O\u2014C 1 -C 4  alkyl, C 1 -C 4  alkyl, fluoro-substituted-C 1 -C 4  alkyl, \u2014N(R 4 )(R 5 ), C 3 -C 10  carbocyclyl or a (4-13 membered) heterocyclyl; or \n R 2  and R 3  taken together with the nitrogen atom to which they are bound form a (4-7 membered) monocyclic heterocylic ring, or a (6-13 membered) bicyclic, spirocyclic or bridged heterocylic ring, wherein the (4-7 membered) monocyclic heterocylic ring, or the (6-13 membered) bicyclic, spirocyclic or bridged heterocyclic ring optionally comprises 1 to 4 additional heteroatoms independently selected from N, S and O; and wherein the (4-7 membered) monocyclic heterocylic ring, or the (6-13 membered) bicyclic, spirocyclic or bridged heterocyclic ring is optionally substituted with one or more substituents independently selected from C 3 -C 10  carbocyclyl, (4-13 membered) heterocyclyl, fluoro, chloro, \u2014OH, \u2014C 1 -C 4  fluoroalkyl, \u2014C 1 -C 4  alkyl, \u2014O\u2014C 3 -C 10  carbocyclyl, \u2014O-(4-13 membered) heterocyclyl, \u2014C 0 -C 4  alkylene-O\u2014C 1 -C 4  alkyl, \u2014C 0 -C 4  alkylene-O\u2014C 1 -C 4  fluoroalkyl, \u2550O, \u2014C(O)\u2014C 1 -C 4  alkyl, \u2014C(O)N(R 4 )(R 5 ), \u2014N(R 4 )\u2014C(O)\u2014C 1 -C 4  alkyl, and \u2014C 0 -C 4  alkylene-N(R 4 )(R 5 ), and wherein each carbocyclyl or heterocyclyl substituent is optionally substituted with fluoro, chloro, \u2014OH, C 1 -C 4  fluoroalkyl, C 1 -C 4  alkyl, \u2014O\u2014C 1 -C 4  alkyl, \u2014O\u2014C 1 -C 4  fluoroalkyl, \u2014NH 2 , \u2014NH(C 1 -C 4  alkyl), or \u2014N(C 1 -C 4  alkyl) 2 ; \n each of R 4  and R 5  is independently selected from hydrogen and C 1 -C 4  alkyl; or \n R 4  and R 5  taken together with the nitrogen atom to which they are bound form a (4-7 membered) heterocylic ring optionally comprising one additional heteroatom selected from N, S and O, wherein the (4-7 membered) heterocylic ring is optionally substituted with fluoro, chloro, \u2014OH, fluoro-substituted C 1 -C 4  alkyl, \u2014C 1 -C 4  alkyl, or \u2014C 1 -C 4  alkylene-O\u2014C 1 -C 4  alkyl, and is optionally fused to phenyl; \n each m is independently 0, 1 or 2; and \n n is 1 or 2, \n with the proviso that when Z is \u2014NH\u2014C(O)\u2014C 1 -C 4  alkyl-N(R 4 )(R 5 ), X is other than fluoro.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 93.0
- Lexical Diversity: 1.34211
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13319298', '15079926', '13075886', '13391407', '15323081']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.792538504973541
- 35 USC 102 Novelty (BERT): 0.5887673055882451
- Combined Prediction Score: 0.7721613850350113
- Mean Citation Score: 430.592564
- Max Citation Score: 510.6487
- Similarity Product: 449.04886017845286

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test