PATENT CLAIM ANALYSIS

Application Number: 15919640
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["435", "006120"]

Abstract:
The present disclosure provides methods, arrays and kits for assessing the quality of genomic DNA samples, especially those obtained from formalin-fixed paraffin-embedded (FFPE) samples. The methods, arrays and kits provided herein use primer pairs specific to regions in the genomes of the organisms from which genomic DNA samples are obtained that have identical or nearly identical copies distributed across multiple chromosomes.

Claim (Index 17):
The method of  claim 1 , wherein the two or more primer pairs are comprised in a kit, and\n wherein optionally: (i) the number of the primer pairs is 2 to 12 or 4 to 8; (ii) the kit comprises an array, wherein the array comprises a solid support and multiple compartments in the solid support, wherein a first primer pair specific to a first genomic DNA fragment in the test genomic DNA sample is contained in a first compartment or each of a first set of compartments, and wherein (a) the first genomic DNA fragment and (b) one or more fragments nearly identical to the first genomic DNA fragment, if present in the genome of the organism from which the DNA sample is obtained, are located at 10 or more different locations in the genome of the organism from which the test genomic DNA sample is obtained, the array optionally further comprising a second compartment or a second set of compartments, wherein a second primer pair specific to a second genomic DNA fragment in the test genomic DNA is contained in the second compartment or each of the second set of compartments, and wherein (a) the second genomic DNA fragment and (b) one or more fragments nearly identical to the second genomic DNA fragment, if present in the genome of the organism from which the DNA sample is obtained are located at 10 or more different locations in the genome of the organism from which the test genomic DNA sample is obtained, and wherein a genomic DNA fragment is nearly identical to another DNA if (i) the size difference between the two genomic DNA fragments is at most 5% of the full length of the longer fragment, and (ii) the sequence identity between the two fragments is at least 95%; (iii) the kit further comprises a control genomic DNA sample; and/or (iv) the kit further comprises one or more reagents for performing real-time PCR.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 90.0
- Lexical Diversity: 1.36
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14208460', '14652098', '14775435', '14864158', '12678423']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5721714536336867
- 35 USC 102 Novelty (BERT): 0.5927903939689044
- Combined Prediction Score: 0.5742333476672086
- Mean Citation Score: 403.928404
- Max Citation Score: 607.0267
- Similarity Product: 401.32425634849074

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test