PATENT CLAIM ANALYSIS

Application Number: 16206395
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "248000"]

Abstract:
The present application provides novel pyrimido-pyridazinone compounds and methods for preparing and using these compounds. These compounds are useful in treating inflammation in patients by administering one or more of the compounds to a patient. In one embodiment, the novel pyrimido-pyridazinone compound is of Formula (I) and R 1  and R 2  are defined herein.

Claim (Index 1):
A compound of Formula (I): wherein:\n R 1  is NR 4 R 5 , optionally substituted C 1  to C 6  alkoxy, optionally substituted C 6  to C 14  aryl, optionally substituted heteroaryl, optionally substituted 3-10 membered monocyclic or bicyclic cycloalkyl, or optionally substituted 3-10 membered monocyclic or bicyclic heterocyclyl, wherein: \n (i) 3-4 membered cycloalkyl and heterocyclyl are saturated; \n (ii) hydrogen atoms on the same carbon atom of said cycloalkyl or heterocyclyl are optionally replaced with an optionally substituted 3-6 membered cycloalkyl or heterocyclyl to form a spirocycloalkyl or spiroheterocyclyl; and \n (iii) hydrogen atoms on the same atom of said cycloalkyl or heterocyclyl are optionally replaced with O to form an oxo substituent; \n R 2  is optionally substituted phenyl, \u2014O\u2014(C 1  to C 6  alkyl)-optionally substituted phenyl, or optionally substituted 5-6 membered heteroaryl, with the proviso that when R 2  is 4-pyridyl, the 4-pyridyl lacks a carbonyl substituent at the 2 nd  position; \n R 4  and R 5  are:\n (a) independently selected from the group consisting of H, C 1  to C 6  alkyl, C 1  to C 6  hydroxyalkyl, C 3  to C 8  cycloalkyl, and \u2014(C 1  to C 6  alkyl)N(C 1  to C 6  alkyl)(C 1  to C 6  alkyl); \n (b) joined to form an optionally substituted 3-8 membered heterocyclyl, wherein;\n (bi) hydrogen atoms on the same carbon atom of said heterocyclyl are optionally replaced with an optionally substituted 3-6 membered cycloalkyl or heterocyclyl to form a spirocycloalkyl or spiroheterocyclyl; and \n (bii) hydrogen atoms on the same atom of said heterocyclyl (b), cycloalkyl (bi), or heterocyclyl (bi), are optionally replaced with O to form an oxo substituent; \n \n \n or a pharmaceutically acceptable salt or ester thereof.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 98.0
- Lexical Diversity: 1.35556
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13592511', '15137950', '14244183', '13552876', '15645775']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8305250663772796
- 35 USC 102 Novelty (BERT): 0.6510042785934267
- Combined Prediction Score: 0.8125729875988944
- Mean Citation Score: 501.49154000000016
- Max Citation Score: 609.8373
- Similarity Product: 602.8712425990641

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test