PATENT CLAIM ANALYSIS

Application Number: 16038968
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["514", "252120"]

Abstract:
(−)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.

Claim (Index 1):
A method for preparing a compound of Formula (I): comprising contacting a compound of Formula (II): with a transition metal catalyst (preferably a chiral transition metal catalyst) under hydrogenation conditions, wherein, as valence and stability permit: R 1  and R 7  are each independently hydrogen, hydroxyl, halogen, nitro, alkyl, alkenyl, alkynyl, cyano, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, trialkylsilyloxy, or acylamino; each instance of R 2 , R 3 , R 4 , R 5 , R 8 , R 9 , R 10 , and R 11  is independently hydrogen, hydroxyl, halogen, nitro, alkyl, alkenyl, alkynyl, cyano, carboxyl, sulfate, amino, alkoxy, alkylamino, alkylthio, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, trialkylsilyloxy, acylamino, aryl, heteroaryl, carbocyclyl, heterocyclyl aralkyl, aralkyloxy, hetaralkyl, carbocyclylalkyl, or heterocyclylalkyl; R 6  is hydrogen, hydroxyl, halogen, nitro, cyano, carboxyl, sulfate, alkyl, alkenyl, alkynyl, amino, alkoxy, alkylamino, alkylthio, ether, thioether, ester, amide, thioester, carbonate, carbamate, urea, sulfonate, sulfone, sulfoxide, sulfonamide, acyl, acyloxy, trialkylsilyloxy, or acylamino; or any two of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , together with the carbon atoms to which they are attached, form an aryl, heteroaryl, carbocyclyl, or heterocyclyl; or any two of R 7 , R 8 , R 9 , R 10 , and R 11 , together with the carbon atoms to which they are attached, form an aryl, heteroaryl, carbocyclyl, or heterocyclyl; and R 12  is H, alkyl or aralkyl.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 95.0
- Lexical Diversity: 1.42308
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15366590', '14972475', '14514001', '15081157', '14960799']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8250145823963994
- 35 USC 102 Novelty (BERT): 0.5776955954819072
- Combined Prediction Score: 0.8002826837049501
- Mean Citation Score: 493.983978
- Max Citation Score: 515.08453
- Similarity Product: 397.2285542585933

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test