PATENT CLAIM ANALYSIS

Application Number: 16277823
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-08
Patent Classification: ["435", "440000"]

Abstract:
Engineered Cas9 systems that utilize alternate protospacer adjacent motifs for target DNA binding, nucleic acids encoding said engineered Cas9 systems, and methods of using said engineered Cas9 systems for modifying target chromosomal sequences in eukaryotic cells.

Claim (Index 11):
The system of  claim 1 , wherein the engineered Cas9 protein is from  Bacillus smithii  and the PAM sequence it recognizes is 5\u2032-NNNNCAAA-3\u2032, the engineered Cas9 protein is from  Lactobacillus rhamnosus  and the PAM sequence it recognizes is 5\u2032-NGAAA-3\u2032, the engineered Cas9 protein is from  Parasutterella excrementihominis  and the PAM sequence it recognizes is 5\u2032-NGG-3\u2032, the engineered Cas9 protein is from  Mycoplasma canis  and the PAM sequence it recognizes is 5\u2032-NNGG-3\u2032, the engineered Cas9 protein is from  Mycoplasma gallisepticum  and the PAM sequence it recognizes is 5\u2032-NNAAT-3\u2032, the engineered Cas9 protein is from  Akkermansia glycaniphila  and the PAM sequence it recognizes is 5\u2032-NNNRTA-3\u2032, the engineered Cas9 protein is from  Akkermansia muciniphila  and the PAM sequence it recognizes is 5\u2032-MMACCA-3\u2032, the engineered Cas9 protein is from  Oenococcus kitaharae  and the PAM sequence it recognizes is 5\u2032-NNG-3\u2032, the engineered Cas9 protein is from  Bifidobacterium bombi  and the PAM sequence it recognizes is 5\u2032-NNNNGRY-3\u2032, the engineered Cas9 protein is from  Acidothermus cellulolyticus  and the PAM sequence it recognizes is 5\u2032-NGG-3\u2032, the engineered Cas9 protein is from  Alicyclobacillus hesperidum  and the PAM sequence it recognizes is 5\u2032-NGG-3\u2032, the engineered Cas9 protein is from  Wolinella succinogenes  and the PAM sequence it recognizes is 5\u2032-NGG-3\u2032, the engineered Cas9 protein is from  Nitratifractor salsuginis  and the PAM sequence it recognizes is 5\u2032-NRGNK-3\u2032, the engineered Cas9 protein is from  Ralstonia syzygii  and the PAM sequence it recognizes is 5\u2032- GGGRG-3\u2032 or the engineered Cas9 protein is from  Corynebacterium diphtheria  and the PAM sequence it recognizes is 5\u2032-NNAMMMC-3\u2032, wherein K is G or T; M is A or C: N is A, C, G, or T; R is A or G; and Y is C or T.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 99.0
- Lexical Diversity: 1.3
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16031819', '14105017', '14523799', '15179353', '14259420']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6251994059367522
- 35 USC 102 Novelty (BERT): 0.5294632944314744
- Combined Prediction Score: 0.6156257947862245
- Mean Citation Score: 351.208168
- Max Citation Score: 360.2345
- Similarity Product: 259.2655287294388

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test