PATENT CLAIM ANALYSIS

Application Number: 15747843
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "265100"]

Abstract:
The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Claim (Index 7):
A compound according to  claim 6  of the formula wherein:\n R 2  is hydrogen or NHCOR 7 ; \n R 3  is hydrogen, halogen, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, \u2014CONR 8 R 9  or \u2014OR 10 ; \n R 4  is (C 1 -C 6 )alkyl, \u2014CH 2 NR 11 R 12  or \u2014CONR 11 R 12 ; \n R x  is hydrogen, halogen, (C 1 -C 6 )alkyl or \u2014NHCO(C 1 -C 6 )alkyl; \n R 6  is hydrogen, halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, \u2014CHF 2 , \u2014CFH 2 , CF 3 , (C 3 -C 8 )cycloalkyl, \u2014NH 2  or NHSO 2 (C 1 -C 6 )alkyl; \n R 7  is (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 3 -C 8 )cycloalkyl, heterocyclylalkyl, amino(C 1 -C 6 )alkyl or hydroxy(C 1 -C 6 )alkyl; \n R 8  is hydrogen, (C 1 -C 6 )alkoxy or (C 1 -C 6 )alkyl; \n R 9  is hydrogen or a 5-8 membered heterocyclic ring containing 1-4 heteroatoms selected from \u2014O\u2014, \u2014S\u2014 or \u2014N\u2014; or \n R 8  and R 9  are taken together with the nitrogen to which they are attached to form a 5-8 membered heterocyclic ring containing 1-4 heteroatoms selected from \u2014O\u2014, \u2014S\u2014 or \u2014N\u2014; \n R 10  is (C 1 -C 6 )alkyl; \n R 11  is hydrogen, amino(C 1 -C 6 )alkyl or hydroxy(C 1 -C 6 )alkyl; \n R 12  is hydrogen, amino(C 1 -C 6 )alkyl or hydroxy(C 1 -C 6 )alkyl; \n n is 0 or 1; \n or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 86.0
- Lexical Diversity: 1.43333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15755636', '14977709', '15612030', '13534127', '15088211']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.798402776339721
- 35 USC 102 Novelty (BERT): 0.5228456560155991
- Combined Prediction Score: 0.7708470643073089
- Mean Citation Score: 307.65078
- Max Citation Score: 335.2428
- Similarity Product: 277.01465085339544

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test