PATENT CLAIM ANALYSIS

Application Number: 15744485
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "492000"]

Abstract:
Methods for reducing platinum drug-induced toxicity in a cell expressing Organic Cation Transporter 2 (OCT2), methods for reducing platinum drug-induced toxicity in a subject, methods for treating cancer, methods for increasing efficacy of platinum drug treatment in a subject, and pharmaceutical compositions are described. The described methods and compositions include an OCT2 inhibitor where the OCT2 inhibitor is buflomedil or a salt thereof, dolutegravir or a salt thereof contains an imidazole, or is miconazole or a salt thereof.

Claim (Index 61):
The method of any one of  claims 1 - 60 , wherein the cancer is selected from the group consisting of adenocarcinoma of the pancreas, ampullary and periampullary carcinoma, adenocarcinoma of the anus, appendiceal carcinoma, hepatocellular carcinoma, carcinoma of the colon or rectum, epithelial ovarian carcinoma, fallopian tube carcinoma, primary peritoneal cancer, esophageal or esophagogastric junction carcinoma, gastric carcinoma, small bowel carcinoma, testicular cancer, cholangiocarcinoma, pancreatic adenocarcinoma, carcinoma of unknown primary origin, chronic lymphocytic leukemia/small lymphocytic lymphoma, non-Hodgkin's lymphoma, adult T-cell leukemia/lymphoma, AIDS-related B-cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, gastric MALT lymphoma, nongastric MALT lymphoma, mantle cell lymphoma, mycosis fungoides/Sezary syndrome, splenic marginal zone lymphoma, peripheral T cell lymphoma, primary cutaneous B-cell lymphoma, primary cutaneous anaplastic large cell lymphoma (ALCL), lung cancer, liver cancer, head and neck cancer, prostate cancer, smooth muscle cancer and gallbladder cancer.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 86.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12836398', '13147751', '14175295', '11638193', '15314200']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8097980351199896
- 35 USC 102 Novelty (BERT): 0.5080751390701218
- Combined Prediction Score: 0.7796257455150029
- Mean Citation Score: 256.733086
- Max Citation Score: 260.66200000000003
- Similarity Product: 170.34200087797643

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test