PATENT CLAIM ANALYSIS

Application Number: 16306696
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-06
Patent Classification: ["546", "114000"]

Abstract:
It is an object of the present invention to provide a compound inhibiting the binding between ALS-related mutant SOD1 and Derlin-1, a medicament comprising the compound, and a method for treating ALS by administering the medicament to a patient. More specifically, the aforementioned compound is represented by the following formula (1): wherein X represents a sulfur atom or —CH═CH—; A 1  to A 4  each independently represent a carbon atom or a nitrogen atom, and at least one of A 1  to A 4  is a nitrogen atom; R 1  represents a 1,2,3,4-tetrahydroquinolyl group (or a 3,4-dihydro-1(2H)-quinolyl group), a 3,4-dihydro-4,4-dimethyl-1(2H)-quinolyl group, a 2,3,4,5-tetrahydro-1H-1-benzazepinyl group, or a substituent represented by the following formula (2): wherein R 4  represents an unsubstituted or optionally substituted phenyl group, an unsubstituted or optionally substituted pyridyl group, or an unsubstituted or optionally substituted naphthyl group, and R 5  represents any one of a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group (optionally containing an oxygen atom and/or a double bond), or an unsubstituted or optionally substituted aromatic lower alkyl group; R 2  represents a hydrogen atom, a lower alkyl group, a lower acyl group, or an unsubstituted or optionally substituted aromatic lower alkyl group; and R 3  represents a hydrogen atom, or R 2  and R 3  may bind to each other to form a ring.

Claim (Index 10):
The compound according to  claim 2  or a salt thereof, or a solvate or hydrate thereof, wherein the compound represented by the formula (1a) is selected from the group consisting of N-allyl-3-amino-N-phenyl-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-propargyl-3-amino-N-phenyl-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, (3-amino-6-(3-pyridinyl)thieno[2,3-b]2-pyridinyl)(3,4-dihydro-(2H)-quinolinyl)methanone, 3-amino-N-(4-pyridinyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(trans-2-butenyl)-N-phenyl-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-pyridinyl)-6-(2-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-(3\u2032,5\u2032-bis(rifluoromethyl)biphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(2,5-difluorophenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(2-butynyl)-N-phenyl-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-n-propyl-3-amino-N-phenyl-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-n-propyl-3-amino-N-(2,3,4-trifluorophenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(4-iodophenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-(3-methyl-2-butenyl)-3-amino-N-phenyl-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, [3-amino-6-(3-pyridinyl)thieno[2,3-b]2-pyridinyl](2,3,4,5-tetra hydro-1H-benzo[b]azepin-1-yl)methanone, N-allyl-3-amino-N-(2,4-difluorophenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(2,3-difluorophenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(2,5-difluorophenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(5-fluoro-2-methylphenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(3,4-difluorophenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(3,5-difluorophenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(3-(pentafluoro-\u03bb 6 -sulfanyl)phenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(3,5-difluorophenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, N-allyl-3-amino-N-(3-(pentafluoro-\u03bb 6 -sulfanyl)phenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(1-naphthyl)-N-phenyl-6-(3-pyridinyl)thien[2,3-b]pyridine-2-carboxamide, 3-amino-N-(2,6-dimethylphenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-[4-(benzyloxy)phenyl]-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-iodophenyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(2-iodo-4-pyridinyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-6-(3-pyridinyl)-N-(4-(trifluoromethyl)phenyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(3\u2032,5\u2032-bis(trifluoromethyl)-[1,1-biphenyl]-4-yl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-6-(4-pyridinyl)-N-(3-(trifluoromethyl)phenyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-pyridinyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-pyridinyl)-6-(5-pyrimidinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-fluorophenyl)-N-(2-methylprop-2-en-1-yl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-fluorophenyl)-N-(prop-2-yn-1-yl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-phenyl-N\u2014((Z)-4-(prop-2-yloxy)but-2-enyl)-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-benzyl-N-phenyl-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-((E)-4-(pent-4-ynyloxy)but-2-enyl)-N-phenyl-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-prenyl-N-(4-pyridinyl)-1-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(2-cyclopentylideneethyl)-N-phenyl-6-(3-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-6-(3-pyridinyl)thieno[2,3-b]2-pyridinyl)(3,4-dihydro-4,4-dimethyl-1 (2H)-quinolinyl)methanone, 3-amino-N-(4-tert-butylphenyl)-N-(3-methylbut-2-en-1-yl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-6-(4-pyridinyl)thieno[2,3-b]2-pyridinyl)(3,4-dihydro-4,4-dimethyl-1 (2H)-quinolyl)methanone, 3-amino-N-(3-methoxyphenyl)-N-prenyl-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-methoxyphenyl)-N-prenyl-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide, and 3-amino-N-metallyl-N-phenyl-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 99.0
- Lexical Diversity: 2.82105
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['10518725', '11096375', '12187936', '15661786', '13637127']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.813936756910273
- 35 USC 102 Novelty (BERT): 0.5038599474397991
- Combined Prediction Score: 0.7829290759632256
- Mean Citation Score: 270.232816
- Max Citation Score: 283.7195
- Similarity Product: 209.20391802316905

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test