PATENT CLAIM ANALYSIS

Application Number: 15885736
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["435", "006120"]

Abstract:
Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation device described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation device can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation device can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation device can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device. Also included are methods for selectively isolating cellular material using the devices described herein, as are methods for biochemical analysis of individual regions of interest of cellular material using the devices described herein. Further included are methods of making masking arrays useful for the methods described herein. The micro-isolation devices can comprise a unique combination of barcodes in each microfluidics well, allowing two-dimensional mapping of genetic information.

Claim (Index 20):
The method of  claim 17 , wherein carrying out morphogenomic analysis comprises determining a gene frequency or a mutation frequency in different regions of the tissue slide corresponding to different assembled microfluidics wells.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 86.0
- Lexical Diversity: 2.225
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15885352', '15826007', '13378924', '15723490', '12920577']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5255755906400331
- 35 USC 102 Novelty (BERT): 0.5267814853445271
- Combined Prediction Score: 0.5256961801104826
- Mean Citation Score: 189.298708
- Max Citation Score: 323.02087
- Similarity Product: 242.7771036484313

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test