PATENT CLAIM ANALYSIS

Application Number: 16079440
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-05
Patent Classification: ["436", "514000"]

Abstract:
Provided is a single-channel chemiluminescent micro-fluidic chip, including a chip body with a quantification-reaction cavity and a waste liquid cavity. The quantification-reaction cavity is composed of a quantification-reaction pool on a lower portion and a reaction pool cover plate, the quantification-reaction pool is equally divided into three cavities by two partition plates, a labeled antibody is placed in the middle cavity, coated antibodies are placed in the others, a surface, facing the quantification-reaction pool, of the reaction pool cover plate is equally divided into two parts. In result, the coated antibodies and the labeled antibodies are physically separated to effectively avoid nonspecific binding. Due to a special structure of the reaction tank, wavy fluid flow is generated to fully mix the coated antibodies and the labeled antibodies, which improves testing efficiency and sensitivity.

Claim (Index 9):
A single-channel chemiluminescent micro-fluidic chip, including a chip body; characterized in that the chip body is of a three-piece structure and includes an upper chip layer, a middle chip layer and a lower chip layer sequentially stacked together from top to bottom, and every two of the upper chip layer, the middle chip layer and the lower chip layer are stacked together through cooperative connection of positioning columns and positioning holes; wherein:\n a whole blood filter tank, a quantification-reaction pool and a waste liquid pool are disposed on the lower chip layer, a fluid outlet of the whole blood filter tank is sequentially communicated with the quantification-reaction pool and the waste liquid pool through a micro-fluidic passage, a fluid inlet of the quantification-reaction pool is communicated with corresponding external fluid paths through a cleaning solution delivery branch and a chromogenic reagent delivery branch respectively, and the whole blood filter tank is communicated with an external air path; the quantification-reaction pool is equally divided into three cavities by two partition plates a disposed perpendicular to a fluid flow direction, a labeled antibody is placed in the middle cavity, and coated antibodies are placed in the partitioned cavities on two sides; and a surface, facing the quantification-reaction pool, of the reaction pool cover plate is equally divided into two cover plate parts by a partition plate b disposed perpendicular to the fluid flow direction, and the coated antibodies are embedded in the cover plate parts; the middle chip layer is provided with a sample inlet part at a position corresponding to the whole blood filter tank, the reaction pool cover plate, used for sealing an opening of the quantification-reaction pool, is disposed at a position corresponding to the quantification-reaction pool, a middle cover plate, used for sealing an opening of the waste liquid pool, is disposed at a position corresponding to the waste liquid pool, a cleaning solution connector is disposed at a position corresponding to a fluid inlet of the cleaning solution delivery branch, and a chromogenic reagent connector is disposed at a position corresponding to a fluid inlet of the chromogenic reagent delivery branch; the upper chip layer is provided with a sample inlet part through hole at a position corresponding to the sample inlet part, an optical path scanning window is disposed at a position corresponding to the reaction pool cover plate, an upper cover plate is disposed at a position corresponding to the middle cover plate, a cleaning solution connector through hole is disposed at a position corresponding to the cleaning solution connector, and a chromogenic reagent connector through hole is disposed at a position corresponding to the chromogenic reagent connector; a first anti-backflow device is disposed at the micro-fluidic passage between the whole blood filter tank and the quantification-reaction pool, and a second anti-backflow device is disposed on the micro-fluidic passage from a junction of the cleaning solution delivery branch and a chromogenic reagent delivery branch to the quantification-reaction pool; the first anti-backflow device and the second anti-backflow device are of a same structure and each includes an anti-backflow structure located above the micro-fluidic passage and provided with an anti-backflow passage for increasing a liquid level of the micro-fluidic passage at an anti-backflow structure mounting position; and when the micro-fluidic passage is communicated with the external air path, fluid in the micro-fluidic passage on both sides of each said anti-backflow device is driven by air from the external air path to circulate by overcoming a pressure generated by the liquid level, increased by the corresponding anti-backflow passage at the corresponding anti-backflow structure mounting position, of the micro-fluidic passage; a valve device is disposed on the micro-fluidic passage between the quantification-reaction pool and the waste liquid pool and includes a detection mechanism used to sense whether or not fluid flows through a valve device mounting position; the valve device in a normally-open state in the chip body automatically closes to be in an interruption state when a numerical value fed back by the detection mechanism indicates that fluid flows through the valve device mounting position, and the valve device in the interruption state can be regularly opened to be in a circulation state; and when the valve device is in the circulation state, fluid is pushed by air flow from the external air path to circulate in the valve device.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 96.0
- Lexical Diversity: 2.0137
- Patent Class: 436.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12876883', '12202414', '10801180', '13346615', '13004933']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6426273002831628
- 35 USC 102 Novelty (BERT): 0.4879467072159908
- Combined Prediction Score: 0.6271592409764456
- Mean Citation Score: 178.765272
- Max Citation Score: 189.7442
- Similarity Product: 125.57995482971668

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test