PATENT CLAIM ANALYSIS

Application Number: 15979041
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "402000"]

Abstract:
The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to bisantrene or derivatives, analogs, or prodrugs thereof.

Claim (Index 15):
The method of  claim 14  wherein the drug therapy comprises the administration of bisantrene and wherein the analysis of patient or disease phenotype is carried out by a method selected from the group consisting of:\n (a) use of a diagnostic tool, a diagnostic technique, a diagnostic kit, or a diagnostic assay to confirm a patient's particular phenotype; \n (b) use of a method for measurement of a marker selected from the group consisting of histone deacetylase, ornithine decarboxylase, VEGF, a protein that is a gene product of a prostate specific gene, a protein that is a gene product of jun, and a protein kinase; \n (c) surrogate compound dosing; \n (d) low dose pre-testing for enzymatic status; \n (e) determination of the multi-drug resistance activity of cells; \n (f) determining expression or activation of a signaling or metabolic protein, where an alteration in the level of expression or activation of the signaling or metabolic protein indicates the therapeutic potential of a chemotherapeutic agent; \n (g) detection or assay of expression of biomarkers indicating sensitivity to apoptosis-inducing agents; \n (h) use of an in vitro human tumor clonal assay to determine patients with enhanced responses; \n (i) use of an immunohistochemical assay to determine overexpression of HIF-1\u03b1; \n (j) assessment of p53 mutation; and \n (k) determination of the quantity or activity of topoisomerase 20 in cardiac cells.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 93.0
- Lexical Diversity: 1.31579
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14907728', '14907729', '13817096', '14753911', '14245738']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.788950819125049
- 35 USC 102 Novelty (BERT): 0.5299415264495846
- Combined Prediction Score: 0.7630498898575026
- Mean Citation Score: 267.787678
- Max Citation Score: 348.62634
- Similarity Product: 324.01831687837245

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test