PATENT CLAIM ANALYSIS

Application Number: 16045993
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["514", "230500"]

Abstract:
The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Claim (Index 1):
A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein:\n L is absent, O, S, NHCO or CONH; \n X is CH or N; \n R 1  is H, C 1-4 alkyl, C 1-4 haloalkyl, or 3-6 membered cycloalkyl; \n R 2  is H, \u2014OH, halo, \u2014CN, nitro, C 1-4 alkoxy, C 1-4 alkyl, C 1-4 alkoxy-C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, a 5-10 membered heterocyclyl optionally substituted with 1-3 C 1-4 alkyl groups, \u2014(CH 2 ) n -(6 or 10 membered aryl optionally substituted with 1-3 C 1-4 alkyl groups), or \u2014(CH 2 ) n -(5-10 membered heteroaryl optionally substituted with 1-3 C 1-4 alkyl groups); \n R 3  is H, halo, \u2014OH, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl or C 1-4  haloalkoxy; \n R 4  is a substituted C 2-4 alkynyl, a substituted or unsubstituted 5-10 membered heterocyclyl, a substituted or unsubstituted 5-10 membered heteroaryl, a substituted or unsubstituted 5-10 membered fused heterocyclyl-aryl, a substituted or unsubstituted 5-10 membered fused heterocyclyl-heteroaryl, or a substituted or unsubstituted 6 or 10 membered aryl, wherein when R 4  is substituted, R 4  is substituted with 1-3 substituents independently selected from halo, \u2014OH, oxo (\u2550O), \u2014CN, nitro, C 1-4 alkyl, \u2014C 1-4 alkyl-(3-6 membered cycloalkyl), C 1-4 alkoxy, \u2014SO 2 \u2014C 1-4 alkyl, \u2014SO 2 \u2014C 1-4 hydroxyalkyl, \u2014SO 2 \u2014C 1-4 alkyl-NR 5 R 6 , \u2014NHSO 2 \u2014C 1-4 alkyl, C 1-4 hydroxyalkyl, \u2014SO 2 NR 5 R 6 , \u2014CO\u2014C 1-4 hydroxyalkyl, \u2014CONR 5 R 6 , \u2014CO\u2014C 1-4 alkyl-NR 5 R 6 , \u2014CO\u2014NH\u2014C 1-4 alkyl-NR 5 R 6 , \u2014NR 5 R 6 , \u2014C 1-4 alkyl-NR 5 R 6  and \u2014CO\u2014C 1-4 alkyl; \n R 5  and R 6  are each, independently, selected from H, C 1-4 alkyl, C 1-4 hydroxyalkyl, \u2014CO\u2014C 1-4 alkyl and -(4-10 membered heterocyclyl)-C 1-4 alkyl; or R 5  and R 6 , together with the nitrogen atom to which they are attached, form a 5-7 membered heterocyclyl optionally substituted with 1-3 C 1-4 alkyl groups; and \n n is 0 or 1.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.45763
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12994250', '13114829', '14972482', '13084181', '14774839']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7504014449428092
- 35 USC 102 Novelty (BERT): 0.519225673065855
- Combined Prediction Score: 0.7272838677551139
- Mean Citation Score: 285.825828
- Max Citation Score: 296.1184
- Similarity Product: 228.3974509532929

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test