PATENT CLAIM ANALYSIS

Application Number: 15766011
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["564", "401000"]

Abstract:
The invention relates to novel compounds that are useful for modulating cellular ROS. The compounds are amide-derivatives of 2-hydroxy-2-methyl-4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-butanoic acid. The compounds of the invention are formulated into pharmaceutical or cosmetic compositions. The invention further relates to methods wherein the compounds of the invention are used for treating or preventing diseases associated with increased ROS levels mitochondrial disorders and/or conditions associated with mitochondrial dysfunction, including adverse drug effects. The invention also relates to cosmetic methods for treating or delaying further aging of the skin and veterinary applications.

Claim (Index 39):
The method according to  claim 38 , wherein the clinical marker is one or more markers selected from the group consisting of lactic acid (lactate) levels, either in whole blood, plasma, cerebrospinal fluid, or cerebral ventricular fluid; pyruvic acid (pyruvate) levels, either in whole blood, plasma, cerebrospinal fluid, or cerebral ventricular fluid; lactate/pyruvate ratios, either in whole blood, plasma, cerebrospinal fluid, or cerebral ventricular fluid; amino acids, in particular alanine, citrulline and proline in whole blood, plasma or cerebrospinal fluid, organic acids in body fluids; FGF21 in serum and skeletal muscle; phosphocreatine levels, NADH (NADH+H + ) or NADPH (NADPH+H + ) levels; NAD or NADP levels; ATP levels; anaerobic threshold; reduced coenzyme Q (CoQ red ) levels; oxidized coenzyme Q (CoQ ox  levels; total coenzyme Q (CoQ tot ) levels; oxidized cytochrome C levels; reduced cytochrome C levels; oxidized cytochrome C/reduced cytochrome C ratio; acetoacetate levels, beta-hydroxy butyrate levels, acetoacetate/betahydroxy butyrate ratio, 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG) levels; levels of reactive oxygen species; and levels of oxygen consumption (VO2), levels of carbon dioxide output (VCO2), and respiratory quotient (VCO2/VO2).

Metadata:
- Claim Count in Document: 14.0
- Percentile: 91.0
- Lexical Diversity: 1.70175
- Patent Class: 564.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14414055', '15442475', '15550273', '15037941', '15502330']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7139428098578359
- 35 USC 102 Novelty (BERT): 0.5574682368826535
- Combined Prediction Score: 0.6982953525603176
- Mean Citation Score: 246.22474000000005
- Max Citation Score: 380.35
- Similarity Product: 297.6669147312641

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test