PATENT CLAIM ANALYSIS

Application Number: 16075528
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "560000"]

Abstract:
The present invention relates to a class of fatty acid compounds, a preparation method thereof and use thereof. The fatty acid compounds have the structure of the formula I, which has the ability to activate APMK and inhibit the glucose output in mouse primary hepatocytes. The fatty acid compounds can be used in preparing a medicament for the treatment of obesity or diabetes.

Claim (Index 7):
A method for preparing the fatty acid compound represented by following formula I according to  claim 1 , the method comprises the following steps: (1) reacting substituted ethyl acetate A1 with dibromoalkane A2 in the presence of lithium diisopropylamide and an organic solvent to obtain intermediate A3; under the same conditions, replacing A1 with and reacting with A2 to give A4;\n (2) reacting equivalent A3 and A4 with tosylmethyl isocyanide in the presence of NaH, tetrabutylammonium iodide, and dimethyl sulfoxide to obtain compound A5; \n (3) reacting A5 with concentrated hydrochloric acid to remove hydrocyanic acid and p-toluenesulfonic acid to obtain A6; \n (4) under alkaline conditions, conducting A6 a hydrolysis reaction and acidulating by dilute hydrochloric acid to obtain A7; \n (5) further reducing A7 with sodium borohydride to obtain A8; \n (6) refluxing a toluene solution including of A8 and the catalyst p-toluenesulfonic acid to obtain a compound A9 or A10; \n the definitions of R 3 , R 4 , R 5 , R 6 , n and m are the same as described in  claim 1 .

Metadata:
- Claim Count in Document: 6.0
- Percentile: 96.0
- Lexical Diversity: 1.51111
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15326310', '15109101', '14398643', '15505052', '09972743']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7913089080935247
- 35 USC 102 Novelty (BERT): 0.5196449436148923
- Combined Prediction Score: 0.7641425116456615
- Mean Citation Score: 300.82333
- Max Citation Score: 318.17914
- Similarity Product: 240.7505973905837

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test