PATENT CLAIM ANALYSIS

Application Number: 16152008
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["544", "366000"]

Abstract:
Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.

Claim (Index 1):
A compound having structure Formula (IX): or an optically pure stereoisomer or pharmaceutically acceptable salt thereof, wherein, U is selected from the group consisting of hydrogen, alkyl, arylalkyl, alkoxyalkyl, arylalkoxy, alkynylalkyl, alkylalkynylalkyl, alkenylalkyl, alkylalkenylalkyl, cycloalkyl, cyanoalkyl, cycloalkylalkyl, heteroalkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkylalkyl, haloalkyl, halogen, amino, amido, nitro, and cyano, any of which may be optionally substituted, and U is not R 1 , R 2 , R 3 , and R 4  are each independently selected from the group consisting of alkoxy, alkyl, alkynyl, amino, amido, halogen, hydroxyl, haloalkyl, perhaloalkyl, perhaloalkoxy, nitro, and cyano, any of which may be optionally substituted;\n A is CR 5  or N; \n B is CR 6  or N; \n E is CR 7  or N; \n L is CR 8  or N; \n Q is O or CH 2 ; \n R 5 , R 6 , R 7 , and R 8  are each independently selected from the group consisting of hydrogen, alkoxy, alkyl, alkynyl, amino, halogen, hydroxyl, haloalkyl, perhaloalkyl, perhaloalkoxy, nitro, and cyano, any of which may be optionally substituted; \n T is OR 9  or hydrogen; \n R 9  is hydrogen or alkyl optionally substituted; \n G is (CH 2 ) z  or G and R 9  together with the atom(s) to which they are attached may optionally be joined together to form a monocyclic heterocyclic including, but not limited to, dioxolane; \n z is an integer between 0 and 2; \n m is an integer between 0 and 5; \n n and q are each independently an integer between 0 and 2; \n p is an integer between 0 and 4; \n D is selected from the group consisting of: \n wherein,  is a single or double bond; R 10  is selected from the group consisting of hydrogen, alkyl, arylalkyl, alkoxyalkyl, arylalkoxy, alkynylalkyl, alkylalkynylalkyl, alkenylalkyl, alkylalkenylalkyl, cycloalkyl, cyanoalkyl, cycloalkylalkyl, heteroalkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkylalkyl, and alkylsulfonyl, any of which can be optionally substituted; I is (CH 2 ) r  or NH; J is (CH 2 ) s  or NH; K is (CH 2 ) t  or NH; r, s, and t are each independently an integer between 0 and 4.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 97.0
- Lexical Diversity: 1.27586
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14343040', '15225021', '15481542', '14156314', '14753537']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.800981422606384
- 35 USC 102 Novelty (BERT): 0.5391162694872198
- Combined Prediction Score: 0.7747949072944676
- Mean Citation Score: 330.6821940000001
- Max Citation Score: 383.66406
- Similarity Product: 259.4378574805427

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test