PATENT CLAIM ANALYSIS

Application Number: 15758662
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["424", "078170"]

Abstract:
The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from quinolones, NSAIDs and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click cycloaddition chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the post-surgical care to treat or prevent infections, provide analgesia and treat inflammation.

Claim (Index 46):
A polymer-bioactive agent conjugate according to  claim 45 , wherein the bioactive agent is selected from quinolone antibiotics of formula (Xi) or (Xii): wherein:\n A 1  is selected from N or \u2014CY 1 \u2014 where Y 1  is hydrogen, halogen, alkyl, haloalkyl, \u2014O-alkyl, halo(C 1  to C 4 alkoxy), \u2014S-alkyl, nitrile, an amine, an amino radical, NO 2 , and the group wherein Y 1  forms a bridge with B 1 ; \n A 2  is selected from N or \u2014CY 2 \u2014 where Y 2  is selected from hydrogen, halogen, alkyl, \u2014O-alkyl, \u2014S-alkyl, an amine, an amino radical, NO 2  and the group wherein Y 2  forms a bridge with E; \n A 3  is selected from N or \u2014C\u2014; \n A 4  is selected from N, \u2014CB 3  wherein B 3  is H or together with B1 forms a bridge \u2014B 3 \u2014B 1 \u2014 wherein B 3  is \u2014S\u2014 and B1 is \u2014CH(B 4 )\u2014 where B 4  is H or methyl; \n B 1  is selected from hydrogen, alkyl, substituted alkyl, optionally substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl; \u2014O-alkyl; and wherein B 1  may form a bridge with A 1  or, when A 4  is CB 3 , a bridge with B 3 , wherein in the bridge \u2014B 3 \u2014B 1 \u2014 the group B 3  is \u2014S\u2014 and B 1  is \u2014CH(B 4 )\u2014 where B 4  is H or methyl; \n B 2  is hydrogen, halogen, \u2014OH, \u2014CH 3 , or an amino radical; \n E is selected from hydrogen; halogen; alkyl; optionally substituted aryl; alkoxy; amino radical; and the group wherein A 2  forms a bridge with E.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 90.0
- Lexical Diversity: 1.81132
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14772981', '15435784', '15458546', '14409612', '13082841']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8174128662511382
- 35 USC 102 Novelty (BERT): 0.5737770712968231
- Combined Prediction Score: 0.7930492867557066
- Mean Citation Score: 466.697574
- Max Citation Score: 501.03647
- Similarity Product: 381.4235788562727

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test