PATENT CLAIM ANALYSIS

Application Number: 16144614
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["424", "501000"]

Abstract:
A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.

Claim (Index 15):
The pharmaceutical composition according to  claim 1 ,\n wherein the weight content of risperidone is 45% of the microspheres, the weight content of the polymer blend is 55% of the microspheres, the weight ratio of the first uncapped PLGA to the second uncapped PLGA is 80:20, the molecular weight of the first uncapped PLGA is 55,000 to 85,000 and the molecular weight of the second uncapped PLGA is 15,000 to 35,000, the intrinsic viscosity of the first uncapped PLGA is 0.45 to 0.55 dL/g and the intrinsic viscosity of the second uncapped PLGA is 0.2 to 0.3 dL/g, and a molar ratio of lactide to glycolide in the first uncapped PLGA is 75:25 and a molar ratio of lactide to glycolide in the second uncapped PLGA is 50:50.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 97.0
- Lexical Diversity: 1.875
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15217696', '14113738', '15347365', '15789091', '15944894']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8073337669333222
- 35 USC 102 Novelty (BERT): 0.7234895366272441
- Combined Prediction Score: 0.7989493439027143
- Mean Citation Score: 633.610656
- Max Citation Score: 821.1476
- Similarity Product: 763.5832366630078

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test