PATENT CLAIM ANALYSIS

Application Number: 15765933
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["530", "315000"]

Abstract:
The present invention relates to new solid phase peptide methods for synthesizing analogues that exhibit oxytocin antagonist activity, specifically Barusiban and its intermediates. Specifically, the present invention relates to a solid phase process for preparing a compound having the formula c[AA 1 -AA 6 ]-AA 7 -ol, wherein AA 1  is propionic acid, AA 2  is preferably D-Trp, AA 3  is Ile, AA 4  is preferably AlloIle, AA 5  is Asn, AA 6  is hCy, and AA 7  is preferably N-Me-Orn-ol, or a pharmaceutically acceptable salt or solvate thereof.

Claim (Index 9):
An intermediate suitable for forming a peptide having pharmaceutical properties, which has the formula:\n X\u2014(CH 2 ) 2 \u2014CO\u2014NH-AA b -Ile-AA d -Asn(P 1 )-hCy(P 2 )\u2014NR-CHQ\u2032-CH 2 OW wherein AA b  is a D-aromatic \u03b1-amino acid; AA d  is an aliphatic \u03b1-amino acid; X is a halogen residue; P 1  is a protecting group P 2  is Trt R is CH 3  or C 2 H 5 ; Q\u2032 is (CH 2 ) n \u2014NP 3 P 4 ; n is 2, 3, or 4; P 3  and P 4  are independently H or an amino-acid protecting group, which may be the same or different from each other and which may the same or different to P 1  and/or P 2 ; and W is H, a protecting group or a resin.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 91.0
- Lexical Diversity: 1.65079
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['11929494', '11457743', '13959931', '15145901', '11938776']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6714491783800461
- 35 USC 102 Novelty (BERT): 0.5169303154525862
- Combined Prediction Score: 0.6559972920873002
- Mean Citation Score: 268.686994
- Max Citation Score: 288.8439
- Similarity Product: 209.5036324342847

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test