PATENT CLAIM ANALYSIS

Application Number: 15965655
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["544", "010000"]

Abstract:
The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Claim (Index 1):
A method of treating a hepatitis B infection in a patient in need thereof, comprising administering to the patient an effective amount of a compound of Formula 1: wherein:\n T is selected from the group consisting of \u2014C(O)\u2014, \u2014CH 2 \u2014C(O)\u2014, \u2014N(C(O)\u2014CH 3 )\u2014, \u2014NH\u2014, \u2014O\u2014, and \u2014S(O) z \u2014, where z is 0, 1 or 2; \n Y is C(R 11 ) 2 , S(O) y , NR Y  and O wherein y is 0 or 1; \n R Y  is selected from the group consisting of H, methyl, ethyl, propyl, phenyl and benzyl; \n R L  is selected from the group consisting of H, methyl, and \u2014C(O)\u2014C 1-3 alkyl; \n L is a bond or C 1-4  straight chain alkylene optionally substituted by one or two substituents each independently selected from the group consisting of methyl (optionally substituted by halogen or hydroxyl), ethenyl, hydroxyl, NR\u2032R\u2033, phenyl, heterocycle, and halogen and wherein the C 1-4  straight chain alkylene may be interrupted by an \u2014O\u2014; \n R 2  is selected from the group consisting of H, \n phenyl or naphthyl (wherein the phenyl or naphthyl may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, \u2014C(O)\u2014 NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, phenyl (optionally substituted by one, two or three substituents each independently selected from the group consisting of halogen, hydroxyl, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, C(O)\u2014 NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), S(O) w \u2014NR\u2032R\u2033 (where w is 1, 2 or 3), \u2014NR\u2032\u2014S(O) w , and \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 1, 2 or 3)), heteroaryl (optionally substituted by one, two or three substituents each independently selected from the group consisting of halogen, hydroxyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 -alkoxy, NR\u2032R\u2033, C(O)\u2014NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), NR\u2032\u2014S(O) w , and \u2014S(O) w \u2014NR\u2032R\u2033(where w is 1, 2 or 3)), C 3-6 cycloalkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 1, 2 or 3), and \u2014NR\u2032\u2014S(O) w , (where w is 1, 2 or 3)), \n 5-6 membered heteroaryl having one, two, or three heteroatoms each independently selected from O, N and S (wherein the 5-6 membered heteroaryl may be optionally substituted on a carbon with one, two, or three substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, phenyl (optionally substituted by one, two or three substituents each independently selected from the group consisting of halogen, hydroxyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, C(O)\u2014NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014OH, \u2014C(O)\u2014C 1-6 alkoxy, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), \u2014NR\u2032\u2014S(O) w , and \u2014S(O) w \u2014NR\u2032R\u2033(where w is 1, 2 or 3)), heteroaryl, heterocycle, NR\u2032R\u2033, \u2014C(O)\u2014NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), \u2014NR\u2032\u2014S(O) w , and \u2014S(O) w \u2014NR\u2032R\u2033(where w is 1, 2 or 3), and on a nitrogen by R\u2032), \n C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl, C 3-10 cycloalkyl (optionally substituted with one, two, or three substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, NR\u2032R\u2033, \u2014C(O)\u2014NR\u2032R\u2033, \u2550CNR\u2032, C 1-6 alkyl, C 1-6 alkoxy, \u2014C(O)\u2014C 1-6 alkyl, and \u2014C(O)\u2014C 1-6  alkoxy, and wherein the C 3-10 cycloalkyl may optionally be a bridged cycloalkyl)), and a 4-6 membered heterocycloalkyl having one or two heteroatoms each independently selected from O, N and S (wherein the 4-6 membered heterocycloalkyl may be optionally substituted with one, two, or three substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, NR\u2032R\u2033, \u2014C(O)\u2014NR\u2032R\u2033, C 1-6 alkyl, C 1-6 alkoxy, \u2014C(O)\u2014C 1-6 alkyl, and \u2014C(O)\u2014C 1-6 alkoxy); \n R\u2032 is selected, independently for each occurrence, from H, methyl, ethyl, propyl, phenyl, and benzyl; \n R\u2033 is selected, independently for each occurrence, from H, methyl, ethyl, propyl, butyl, carboxybenzyl, \u2014C(O)-methyl and \u2014C(O)-ethyl, or R\u2032 and R\u2033 taken together may form a 4-6 membered heterocycle; \n each of moieties R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , and R 11  are independently selected for each occurrence from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halogen, hydroxyl, nitro, cyano, NR\u2032R\u2033, \u2014C(O)\u2014NR\u2032R\u2033, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), \u2014NR\u2032\u2014S(O) w , and \u2014S(O) w \u2014NR\u2032R\u2033(where w is 0, 1 or 2), C 1-6 alkoxy, \u2014C(O)\u2014OH, \u2014C(O)\u2014C 1-6 alkyl, and \u2014C(O)\u2014C 1-6 alkoxy; \n wherein for each occurrence, C 1-6 alkyl may be optionally substituted with one, two, or three substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, phenyl, NR\u2032R\u2033, \u2014C(O)\u2014NR\u2032R\u2033, S(O) w -methyl (where w is 1, 2 or 3), \u2014NR\u2032\u2014S(O) w , and S(O) w \u2014NR\u2032R\u2033(where w is 0, 1 or 2); C 1-6 alkoxy may be optionally substituted with one, two, or three substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, phenyl, NR\u2032R\u2033, \u2014C(O)\u2014NR\u2032R\u2033, S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), \u2014NR\u2032\u2014S(O) w , and S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2); and C 3-6 cycloalkyl may be optionally substituted with one, two, or three substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, C 1-6 alkoxy, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, and NR\u2032R\u2033; and \n pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 91.0
- Lexical Diversity: 1.17949
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15125911', '15760343', '15030378', '15566633', '12785665']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7652523243543626
- 35 USC 102 Novelty (BERT): 0.5419060278113262
- Combined Prediction Score: 0.742917694700059
- Mean Citation Score: 347.24217600000014
- Max Citation Score: 395.68375
- Similarity Product: 263.8632773079723

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test