PATENT CLAIM ANALYSIS

Application Number: 15774223
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["424", "233100"]

Abstract:
Compositions and methods are provided for modulating adeno-associated virus (AAV) infection. For example, compositions and methods are provided for enhancing permissiveness of a target cell to AAV infection (e.g., by increasing levels of AAVR (KIAA0319L) in the cell), for reducing permissiveness of a target cell to AAV infection (e.g., by reducing levels of AAVR in the cell), and for nucleic acid delivery (e.g., by (i) increasing permissiveness of a target cell to AAV infection, e.g., by increasing the amount of AAVR in the cell; and (ii) contacting the target cell with an AAV particle that includes a nucleic acid of interest). Also provided are screening methods and kits for practicing the methods of the disclosure.

Claim (Index 69):
A method of identifying a variant adeno-associated virus (AAV) with reduced dependence on a cellular protein, the method comprising:\n (a) contacting a target cell with a candidate AAV particle, wherein:\n (i) said contacting is performed in the presence of a blocking agent that blocks binding between the candidate AAV particle and a target protein of the target cell, wherein the target protein is selected from: adeno-associated virus receptor (AAVR) (KIAA0319L), GPR108, and TM9SF2; and/or \n (ii) the cell is a genetically modified mammalian cell with reduced permissiveness to AAV infection according to any one of  claims 19 - 23 ; \n (b) measuring the amount and/or efficiency of infection by the candidate AAV; (c) determining that the candidate AAV exhibited increased infection compared to a reference AAV; and (d) determining that the candidate AAV is an AAV with reduced dependence on a cellular protein compared to the dependence of the reference AAV.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 93.0
- Lexical Diversity: 2.66038
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10880297', '15367734', '15681267', '15435212', '13840224']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6981898063117347
- 35 USC 102 Novelty (BERT): 0.5252223750109266
- Combined Prediction Score: 0.6808930631816539
- Mean Citation Score: 312.9323080000001
- Max Citation Score: 317.23126
- Similarity Product: 224.8550732388485

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test