PATENT CLAIM ANALYSIS

Application Number: 15755951
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "001100"]

Abstract:
Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

Claim (Index 60):
A method of preparing a compound of Formula (I): or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, the method comprising coupling a carboxylic acid of Formula (D): or a salt thereof, and a compound of Formula (E): or a salt thereof, wherein:\n R 3  is hydrogen, halogen, optionally substituted alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; \n R 4  is hydrogen, halogen, or optionally substituted alkyl; \n R N  is hydrogen, optionally substituted alkyl, optionally substituted acyl, or a nitrogen protecting group; \n or R N  and either R 3  or R 4  are joined to form an optionally substituted heterocyclic ring, or R 3  and R 4  are joined to form an optionally substituted carbocyclic or optionally substituted heterocyclic ring; \n R 5  is hydrogen, halogen, or optionally substituted alkyl; \n R 6  is hydrogen, halogen, optionally substituted alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; \n or R 5  and R 6  are joined to form an optionally substituted carbocyclic or optionally substituted heterocyclic ring; \n R 8  is optionally substituted alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, \u2014C(\u2550O)R 8b , \u2014C(\u2550O)OR 8a , \u2014C(\u2550O)N(R 8a ) 2 , \u2014S(\u2550O) 2 R 8a , or a nitrogen protecting group; \n each occurrence of R 8a  and R 8b  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, an oxygen protecting group, or a nitrogen protecting group, or two R 8a  are joined to form an optionally substituted heterocyclic or optionally substituted heteroaryl ring; \n L 1  is a bond, an amino acid, or a dipeptide; \n each of R c  and R d  is independently hydrogen, optionally substituted alkyl, optionally substituted acyl, or a nitrogen protecting group; and \n each of R A1 , R A2 , R A3 , and R A4  is independently hydrogen, optionally substituted alkyl, optionally substituted acyl, optionally substituted sulfonyl, or a nitrogen protecting group, or any two of R A1 , R A2 , R A3 , and R A4  are joined to form an optionally substituted heterocyclic or optionally substituted heteroaryl ring.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 88.0
- Lexical Diversity: 1.59615
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15104132', '15847430', '15847856', '15904143', '14358606']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7754777580126939
- 35 USC 102 Novelty (BERT): 0.564455722923129
- Combined Prediction Score: 0.7543755545037374
- Mean Citation Score: 416.207098
- Max Citation Score: 435.94302000000016
- Similarity Product: 374.4620219459261

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test