PATENT CLAIM ANALYSIS

Application Number: 16420544
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-09
Patent Classification: ["514", "278000"]

Abstract:
The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

Claim (Index 23):
A method for inhibiting MAGL comprising contacting the MAGL with a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is H, \u2014P(\u2550O)(OR 81 )(OR 82 ); or \u2014S(\u2550O) 2 OR 90 ; \n each of R 81 , R 82 , and R 90  is independently selected from the group consisting of H and C 1-6  alkyl, wherein each of the C 1-6  alkyl is optionally substituted with one or more substituents each independently selected from the group consisting of \u2014NH 2 , \u2014NH(C 1-4  alkyl), and \u2014N(C 1-4  alkyl) 2 ; \n each R S  is independently selected from the group consisting of OH, oxo, halogen, C 1-4  alkyl, C 1-4  haloalkyl, C 3-4  cycloalkyl, C 3-4  cycloalkyl-C 1-2  alkyl-, C 1-4  alkoxy, and C 1-4  haloalkoxy; \n n1 is 0, 1, 2, 3, 4, 5, or 6; \n the moiety of Formula M-10f Formula I \n is a moiety of Formula M-1a, M-1b, or M-1c: each of R 2A  and R 2C  is, independently, \u2014NR 3 S(\u2550O) 2 R 4 , \u2014NR 3 C(\u2550O)R 4 ; R 5 , or \u2014OR 5 ; R 2B  is selected from the group consisting of [4-(trifluoromethyl)-1H-pyrazol-1-yl]methyl-, (cyclopentylcarbonyl)(methyl)amino-, (tert-butylsulfonyl)(methyl)amino-, (2,2-dimethylpropanoyl)(methyl)amino-, 4-(trifluoromethyl)-1H-pyrazol-1-yl-, 4-fluoro-1H-pyrazol-1-yl-3-cyanophenyl-, 6-(trifluoromethyl)pyridin-2-yl-, 5-fluoropyridin-2-yl-, 4-(difluoromethyl)-1H-pyrazol-1-yl-, 4-tert-butyl-1H-pyrazol-1-yl-, 4-chlorol-1H-pyrazol-1-yl-, 4-cyclopropyl-1H-pyrazol-1-yl-, 4-methyl-1H-pyrazol-1-yl-, 2-fluorophenyl-, 4-cyano-3-fluorophenyl-, 3-cyano-4-fluorophenyl-, 5-cyano-2-fluorophenyl-, 4-cyanophenyl-, 2,6-difluorophenyl-, 2,4-difluorophenyl-, 4-fluorophenyl-, 4-(difluoromethyl)pyridin-2-yl-, 6-(difluoromethyl)pyridin-3-yl-, 5-cyanopyridin-2-yl-, 5-(difluoromethyl)pyridin-2-yl-, 5-(trifluoromethyl)pyridin-2-yl-, pyridin-2-yl-, 3-tert-butyl-1H-pyrazol-1-yl-, 3-(trifluoromethyl)-1H-pyrazol-1-yl-, 3,4-dimethyl-1H-pyrazol-1-yl-, {[(3,3-difluorocyclobutyl)methyl]sulfonyl}(methyl)amino-, [(3,3-difluorocyclobutyl)carbonyl](methyl)amino-, 1H-indazol-1-yl-, 3-cyano-2-fluorophenyl-, and 4-cyano-2-fluorophenyl-; each R 3  is independently C 1-3  alkyl; each R 4  is independently selected from C 1-6  alkyl, C 3-7  cycloalkyl, (C 3-7  cycloalkyl)-C 1-2  alkyl-, (C 6-10  aryl)-C 1-2  alkyl-, (5- or 10-membered heteroaryl)-C 1-2  alkyl-, 5- or 10-membered heteroaryl, and C 6-10  aryl, wherein each of the selections is substituted with 0, 1, 2, or 3 halogen; or R 3  and R 4 , together with the intervening moiety of \u201c\u2014NS(\u2550O) 2 \u2014\u201d or \u201c\u2014NC(\u2550O)\u2014\u201d to which they are attached, form a 4- to 10-membered heterocycloalkyl that is substituted with 0, 1, 2, 3, 4, or 5 substituents each independently selected from the group consisting of OH, oxo, halogen, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, and C 1-4  haloalkoxy, and wherein each of the ring-forming atoms of the 4- to 10-membered heterocycloalkyl is C, N, O, or S; and each R 5  is phenyl or 5- or 6-membered heteroaryl, wherein each of the phenyl or 5- or 6-membered heteroaryl is substituted with 0, 1, 2, or 3 substituents each independently selected from the group consisting of \u2014CN, halogen, C 1-4  alkyl, C 3-6  cycloalkyl, C 1-4  alkoxy, C 1-4  haloalkyl, and C 1-4  haloalkoxy, and wherein each of the ring-forming atoms of the 5- or 6-membered heteroaryl is a carbon atom or a nitrogen atom.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 100.0
- Lexical Diversity: 1.52
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15874987', '15221658', '15808242', '14652150', '14902324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7976576383026963
- 35 USC 102 Novelty (BERT): 0.5889908570299035
- Combined Prediction Score: 0.776790960175417
- Mean Citation Score: 395.616206
- Max Citation Score: 519.7040400000002
- Similarity Product: 432.3739140887332

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test