PATENT CLAIM ANALYSIS

Application Number: 15989978
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["552", "542000"]

Abstract:
Assay methods for determining purity of a sample of a sterol are provided. These methods include providing an HPLC eluent including a sterol, other compounds related to the sterol and a mobile volatile phase; generating an aerosol of liquid droplets from the HPLC eluent; drying the liquid droplets to obtain residue particles of the sterol; contacting the residue particles of the sterol with an ion stream which applies a size-dependent electrical charge to each of the residue particles to generate an electrical signal and measuring the electrical signal to determine the purity of the sterol in the sample. The sterol can be OXY133 or OXY133 monohydrate.

Claim (Index 19):
A method for determining purity in a sample of OXY 133 monohydrate, the method comprising:\n providing an oxysterol, the method comprising reacting a diol having the formula: with borane, hydrogen peroxide and tetrahydrofuran to form the oxysterol or a pharmaceutically acceptable salt, hydrate or solvate thereof having the formula: wherein R1 and R2 comprise a hexyl group and the diol comprises (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(S)-2-hydroxyoctan-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol and the hydrate is a monohydrate; subjecting the monohydrate to HPLC to obtain an eluent comprising OXY133 monohydrate, impurities of OXY133 monohydrate and a volatile mobile phase; and charging the HPLC eluent into a CAD detector to determine the purity of OXY133 monohydrate.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 93.0
- Lexical Diversity: 1.88333
- Patent Class: 552.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15082665', '14962651', '14962742', '15474325', '15600375']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6250739479832835
- 35 USC 102 Novelty (BERT): 0.7152507428536319
- Combined Prediction Score: 0.6340916274703183
- Mean Citation Score: 390.601808
- Max Citation Score: 609.7967
- Similarity Product: 589.7106325892447

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test