PATENT CLAIM ANALYSIS

Application Number: 15863501
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["435", "060000"]

Abstract:
The present invention relates compounds for stabilizing cells and methods of their use.

Claim (Index 77):
A method for preventing or reducing cell differentiation in vitro, the method comprising:\n (a) obtaining cells comprising stem cells or progenitor cells; and (b) contacting the cells with an amount of a compound having formula (I) sufficient to prevent or reducing the cells from differentiation as compared to cells in the absence of the compound, wherein the compound of formula (I) is as follows: wherein,\n L 2  is substituted or unsubstituted C 1 -C 10  alkylene; and \n y is an integer from 0 to 3; \n z is an integer from 0 to 5; \n X is \u2014N\u2550, \u2014CH\u2550 or \u2014CR 5 \u2550; \n R 1  is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 3 , R 4  and R 5  are independently \u2014CN, \u2014S(O) n R 6 , \u2014NR 7 R 8 , \u2014C(O)R 9 , \u2014NR 10 \u2014C(O)R 11 , \u2014NR 12 \u2014C(O)\u2014OR 13 , \u2014C(O)NR 14 R 15 , \u2014NR 16 S(O) 2 R 17 , \u2014OR 18 , \u2014S(O) 2 N(R 19 ) 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R 3  moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and \n R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18  and R 19  are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n or a racemate, diastereomer, tautomer, or a geometric isomer thereof, or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 86.0
- Lexical Diversity: 1.0
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15098546', '13132379', '14188616', '13150933', '13500373']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6655970936749817
- 35 USC 102 Novelty (BERT): 0.6045141322957975
- Combined Prediction Score: 0.6594887975370634
- Mean Citation Score: 545.404392
- Max Citation Score: 625.5391
- Similarity Product: 447.4601760316252

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test