PATENT CLAIM ANALYSIS

Application Number: 15911975
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["514", "044000"]

Abstract:
A method of treating cancer in a subject is provided. The method includes administering a splice modulating oligonucleotide to the subject in an amount effective to provide a therapeutic benefit to the subject. In the method, the oligonucleotide modifies splicing of a pre-mRNA encoding a polypeptide promotes cancer cell survival, proliferation, and/or metastasis, or promotes angiogenesis, or a combination thereof; or increases expression of the polypeptide if the polypeptide inhibits angiogenesis, or a combination thereof. Similar methods of treating diseases involving prolactin or the prolactin receptor are also provided.

Claim (Index 29):
The oligonucleotide of  claim 20 , comprising nucleotides that are linked with a phosphorothioate, a phosphorodithioate, a chiral phosphorodithioate, a phosphotriester, an aminoalkylphosphotriester, an alkyl phosphonate, a methyl phosphonate, a 3\u2032-alkylene phosphonate, a chiral phosphonate, a phosphinate, a phosphoramidate, a 3\u2032-amino phosphoramidates, an aminoalkylphosphoramidate, a thionophosphoramidate, a thionoalkylphosphonate, a thionoalkyl phosphotriester, or a boranophosphate backbone.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 90.0
- Lexical Diversity: 1.81818
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14443360', '15833539', '14188168', '13144409', '15288415']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7502326626758863
- 35 USC 102 Novelty (BERT): 0.6099735007705152
- Combined Prediction Score: 0.7362067464853492
- Mean Citation Score: 443.8570820000001
- Max Citation Score: 711.38257
- Similarity Product: 458.5742741238904

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test