PATENT CLAIM ANALYSIS

Application Number: 16159550
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["424", "450000"]

Abstract:
Systems and methods for producing liposomes, including control liposomes and immunoliposomes targeting breast cancer are provided. Systems and methods for treating breast cancer, using targeted immunoliposomes produced according to various methods are also disclosed herein. For example, trastuzumab-conjugated immunoliposomes may be used to deliver chemotherapeutic agents to breast cancer tissues for the treatment of breast cancer. Systems and methods for actuating liposomes using ultrasound are also disclosed, such as systems and methods for actuating trastuzumab-conjugated liposomes accumulated in breast cancer tissues for the treatment of breast cancer.

Claim (Index 1):
A method of treating breast cancer in a mammal, the method comprising:\n delivering an actively targeted liposome to the mammal, the actively targeted liposome comprising:\n a lipid bilayer forming a spherical shell, wherein the spherical shell comprises an interior liposomal cavity, \n a plurality of trastuzumab molecules linked to a surface of the actively targeted liposome, and \n a chemotherapeutic drug, the chemotherapeutic drug comprising at least one of a hydrophilic chemotherapeutic drug contained within the interior liposomal cavity and a hydrophobic chemotherapeutic drug contained within the lipid bilayer of the actively targeted liposome; and \n allowing the actively targeted liposome to circulate throughout a circulatory system of the mammal for a time sufficient to allow aggregation of a therapeutic quantity of actively targeted liposomes at a treatment area comprising a breast cancer; and applying ultrasound to the treatment area such that the actively targeted liposome is critically disrupted thereby releasing the chemotherapeutic drug in the treatment area.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 97.0
- Lexical Diversity: 2.06522
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13912167', '14650355', '14832103', '13817054', '12400988']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6853687126693184
- 35 USC 102 Novelty (BERT): 0.5006801628167099
- Combined Prediction Score: 0.6668998576840576
- Mean Citation Score: 200.951194
- Max Citation Score: 223.86694
- Similarity Product: 145.3341955827999

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test