PATENT CLAIM ANALYSIS

Application Number: 16402098
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-09
Patent Classification: ["435", "006110"]

Abstract:
The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

Claim (Index 2):
A method of associating presence or abundance of a target biological molecule with a location of interest of a tissue sample, comprising:\n delivering a plurality of probes to a tissue sample, wherein at least one probe of the plurality of probes comprises a protein that specifically binds a target biological molecule of the tissue sample, wherein the protein is conjugated to an oligonucleotide having a sequence, and wherein (i) each of the at least one probe comprises a protein that specifically binds a different target biological molecule of the tissue sample, and (ii) the protein of each of the at least one probe is conjugated to a different oligonucleotide having a sequence; imaging the tissue sample to identify a location of interest of the tissue sample; and determining all or a portion of the sequence(s) of the oligonucleotide(s) or a complement thereof, of the at least one probe specifically bound to the target biological molecule(s) in the location of interest of the tissue sample, and using the determined sequence(s) to associate presence or abundance of the target biological molecule(s) with the location of interest of the tissue sample.

Metadata:
- Claim Count in Document: 78.0
- Percentile: 100.0
- Lexical Diversity: 1.48936
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16276260', '13080616', '15187661', '16276235', '14900604']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6150833828901683
- 35 USC 102 Novelty (BERT): 0.5600806196521145
- Combined Prediction Score: 0.6095831065663629
- Mean Citation Score: 320.877444
- Max Citation Score: 364.75662
- Similarity Product: 321.695782379812

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test