PATENT CLAIM ANALYSIS

Application Number: 15938888
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["435", "007230"]

Abstract:
The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based upon the values, predicting the expected benefit including disease-free survival and/or overall survival for the patient without treatment (beyond the surgical removal of tumor tissue) or with a particular treatment and using that information to select a treatment regimen for the subject. High risk subject is identified by high levels of both uPA and PAI-1, high level of uPA and low level of PAI-1 or, low level of uPA and high level of PAI-1. Treatment options for high risk subjects include, but are not limited to, adjuvant CMF chemotherapy, adjuvant non-CMF chemotherapy, adjuvant endocrine therapy, adjuvant anthracyclin-containing chemotherapy, radiation therapy, and gene therapy. Treatment options for low risk subjects include, but are not limited to, no treatment, radiation, and adjuvant endocrine therapy.

Claim (Index 102):
The method of  claim 98  wherein said patient who is classified as high risk has positive hormone receptor status, said positive hormone receptor status comprising positive estrogen receptor status and/or positive progesterone receptor status.

Metadata:
- Claim Count in Document: 73.0
- Percentile: 90.0
- Lexical Diversity: 2.24719
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11965323', '13841887', '13682377', '11450896', '13256910']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4780711045063184
- 35 USC 102 Novelty (BERT): 0.5250633348682978
- Combined Prediction Score: 0.4827703275425163
- Mean Citation Score: 263.74802600000004
- Max Citation Score: 319.97443
- Similarity Product: 223.54655078399296

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test