PATENT CLAIM ANALYSIS

Application Number: 16240677
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["536", "026700"]

Abstract:
In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3  and n are each as defined in Claim  1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

Claim (Index 3):
A method for producing a compound represented by the following formula (II), wherein\n Base independently represents \n wherein each asterisk denotes the site binding to another moiety of the compound represented by the formula (III) above to form said compound; Y 1  independently represents a hydroxyl group protected with a silyl-type protective group, a hydrogen atom, a C 1-6  alkoxy group, or a halogen atom; Q independently represents an oxygen atom; and r and r\u2032 each independently represent an integer of 0 to 100, or a salt thereof, the method comprising the following steps (a2), (b2), and (c2): step (a2):\n reacting a compound represented by the following formula (VII): \n wherein\n X 1  represents a benzyl-type protective group; \n Pr 1  independently represents a protected hydroxyl group protected with a 2-cyano ethyl; \n Pr 2b  represents a halogen atom from fluoro, chloro, bromo, and iodo; \n Base W  independently represents \n wherein each asterisk denotes the site binding to another moiety of the compound represented by the formula (VII) above to form said compound or a base moiety from those represented by the above recited formulae whose amino group or imino group is protected with a protective group for the amino group or imino group of the following formula: wherein\n Z independently represents an oxygen atom; \n ring Ar independently represents a benzene ring; \n R 2  independently represents an optionally substituted C 10-30  alkoxy group; \n R 3  independently represents a halogen atom, cyano group, or optionally substituted C 1-30  alkoxy group; \n n represents an integer of 1 or 2; \n Base is as defined above; \n and\n Y represents a protected hydroxyl group protected with a silyl-type protective group; a hydrogen atom; a halogen atom, or a C 1-6  alkoxy group or a salt thereof with a compound represented by the following formula (IV): \n wherein Pr 3  represents a levulinyl group, and other symbols are as defined above, or a salt thereof to produce a compound represented by the following formula (V): wherein each symbol is as defined above, or a salt thereof; step (b2):\n subjecting the compound represented by the formula (V) or the salt thereof, which is produced in the step (a2), to oxidation reaction or sulfuration reaction to produce a compound represented by the following formula (VI): \n wherein each symbol is as defined above, or a salt thereof; and step (c2):\n subjecting the compound represented by the formula (VI) or the salt thereof, which is produced in the step (b2), to deprotection reaction, \n with the proviso that no silyl or silyloxy substituent moiety can include any Si\u2014H moiety therein.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 99.0
- Lexical Diversity: 1.55696
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14442601', '15118546', '13260096', '10506422', '11658533']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6141330001130153
- 35 USC 102 Novelty (BERT): 0.5522032746367662
- Combined Prediction Score: 0.6079400275653905
- Mean Citation Score: 337.565162
- Max Citation Score: 420.13037
- Similarity Product: 339.5073457465864

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test