PATENT CLAIM ANALYSIS

Application Number: 15772365
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["546", "016000"]

Abstract:
The present invention is directed towards new chemical entities which primarily inhibit the human T-type calcium channels and differentially modulate other key ion channels to control cell excitability, and abnormal neuronal activity particularly involved in the development and maintenance of persistent or chronic pain, and/or neurological disorders. These novel compounds are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which these ion channels are involved. The invention is also directed towards pharmaceutical formulations comprising these compounds and the uses of these compounds.

Claim (Index 1):
A compound of Formula I, or a pharmaceutically acceptable salt thereof, having a structure according to the following formula: wherein\n R 1  is substituted or unsubstituted alkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; \n X is selected from \u2014N(R 14 )\u2014C(\u2550O)\u2014, or \u2014N(R 14 )\u2014S(\u2550O) k \u2014, or \u2014CH 2 \u2014N(R 14 )\u2014C(\u2550O)\u2014, or \u2014CH 2 \u2014N(R 14 )\u2014S(\u2550O) k \u2014, or C(\u2550O)\u2014N(R 14 ), and \u2014CH 2 \u2014C(\u2550O)\u2014N(R 14 ), or CH 2 \u2014N(R 14 );\n k is selected from 1 and 2; and \n R 14  is H or substituted or unsubstituted C 1 -C 6  alkyl; \n \n R 2  is selected from substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl; \n R 3 , R 4 , R 5 , R 6  are each independently hydrogen, substituted or unsubstituted \u2014C 1 0.6 alkyl, substituted or unsubstituted \u2014C 1-6  haloalkyl, a 3-, 4-, 5- or 6-membered substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl group, wherein\n R 3  and R 4  along with the carbon to which they are attached optionally form a 3- to 6-membered substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl group, said heterocycloalkyl group optionally containing 1 or 2 heteroatoms independently selected from O, N or S, and said substituted cycloalkyl or substituted heterocycloalkyl group is optionally substituted with 1, 2, or 3 substituents independently selected from F, \u2014C 1-6  alkyl, and \u2014CF 3  \n R 5  and R 6 , together with the carbon to which they are attached, optionally form a 3-, 4-, 5- or 6-membered substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl group, said heterocycloalkyl group optionally containing 1 or 2 heteroatoms independently selected from O, N or S, and said cycloalkyl or heterocycloalkyl group is optionally substituted with from 1, 2 or 3 substituents independently selected from F, \u2014C 1-6  alkyl, and \u2014CF 3 ; \n \n R 7 , R 8 , R 9 , and R 10  are each independently hydrogen, fluorine, substituted or unsubstituted-C 1-6  alkyl, substituted or unsubstituted-C 1-6  haloalkyl, a 3-, 4-, 5- or 6-membered substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl group, wherein\n R 7  and R 8 , together with the carbon to which they are attached, optionally form a 3-, 4-, 5-, or 6-membered substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl group, said heterocycloalkyl group optionally containing 1 or 2 heteroatoms independently selected from O, N or S, and said substituted cycloalkyl or substituted heterocycloalkyl group is optionally substituted with 1, 2 or 3 substituents independently selected from F, \u2014C 1-6  alkyl, or \u2014CF 3 ; \n R 9  and R 10 , together with the carbon to which they are attached, optionally form a 3-, 4-, 5- or 6-membered substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl group, said heterocycloalkyl group containing from 1 or 2 heteroatoms independently selected from O, N or S, and the substituted cycloalkyl or substituted heterocycloalkyl group is optionally substituted with 1, 2, or 3 substituents independently selected from F, \u2014C 1-6  alkyl, or \u2014CF 3 ; \n \n R 11 , R 12  and R 13  are each independently hydrogen, fluorine, substituted or unsubstituted-C 1-6  alkyl, substituted or unsubstituted-C 1-6  haloalkyl, a 3-, 4-, 5- or 6-membered substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl group, wherein\n R 11  and either R 12  or R 13 , together with the carbons to which they are attached, optionally form a 3-, 4-, 5-, 6- or 7-membered substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl group

Metadata:
- Claim Count in Document: 31.0
- Percentile: 91.0
- Lexical Diversity: 1.55
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12809160', '13908705', '12498185', '15144452', '12850534']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7982101850620641
- 35 USC 102 Novelty (BERT): 0.5244236859418928
- Combined Prediction Score: 0.770831535150047
- Mean Citation Score: 313.04355
- Max Citation Score: 315.04916000000014
- Similarity Product: 209.9130673357106

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test