PATENT CLAIM ANALYSIS

Application Number: 15933889
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "210200"]

Abstract:
The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Claim (Index 10):
A compound selected from the group consisting of\n 5-(3-(((S)-1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(trans-4-morpholinocyclohexyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; 5-(3-(((S)-1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(trans-4-morpholinocyclohexyl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; 5-(3-(((S)-1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(3-(2,2-difluoroethoxy)-1-(trans-4-morpholinocyclohexyl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; 5-(3-(((S)-1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(3-isopropyl-1-(trans-4-morpholinocyclohexyl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; 5-(3-(((S)-1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(trans-4-morpholinocyclohexyl)-3-(oxetan-3-yloxy)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; 5-(3-(((S)-1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(3-(((S)-2,2-difluorocyclopropyl)methoxy)-1-(trans-4-morpholinocyclohexyl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; 2-(((S)-1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-(2-((1-(trans-4-morpholinocyclohexyl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)amino)pyrimidin-5-yl)benzonitrile, or a salt thereof; 5-(3-(((S)-1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(trans-4-((1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)cyclohexyl)-3-(2,2-difluoroethoxy)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; 1-(trans-4-(4-((5-(3-(((S)-1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)pyrimidin-2-yl)amino)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-1-yl)cyclohexyl)-3-methylazetidin-3-ol, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(2-(tetrahydro-2H-pyran-4-yl)-2-azaspiro[3.3]heptan-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(2-(tetrahydro-2H-pyran-4-yl)-2-azaspiro[3.3]heptan-6-yl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(2-(oxetan-3-yl)-2-azaspiro[3.3]heptan-6-yl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-1-(6-(4-((5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)pyrimidin-2-yl)amino)-3-(trifluoromethyl)-1H-pyrazol-1-yl)-2-azaspiro[3.3]heptan-2-yl)-2-methylpropan-2-ol, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(2-(2,2-dimethyl-1,3-dioxan-5-yl)-2-azaspiro[3.3]heptan-6-yl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(3-isopropyl-1-(2-(oxetan-3-yl)-2-azaspiro[3.3]heptan-6-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(3-isopropyl-1-(2-(tetrahydro-2H-pyran-4-yl)-2-azaspiro[3.3]heptan-6-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(2-(4-methyltetrahydro-2H-pyran-4-yl)-2-azaspiro[3.3]heptan-6-yl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; 5-(4-chloro-3-{[(2S)-1-(1H-tetrazol-1-yl)propan-2-yl]oxy}phenyl)-N-(1-{2-[(4- 2 H)tetrahydro-2H-pyran-4-yl]-2-azaspiro[3.3]heptan-6-yl}-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-1-(6-(4-((5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)pyrimidin-2-yl)amino)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-1-yl)-2-azaspiro[3.3]heptan-2-yl)-2-methylpropan-2-ol, or a salt thereof; (S)-1-(6-(4-((5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)pyrimidin-2-yl)amino)-3-isopropyl-1H-pyrazol-1-yl)-2-azaspiro[3.3]heptan-2-yl)-2-methylpropan-2-ol, or a salt thereof; (S)-1-(4-((5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)pyrimidin-2-yl)amino)-1-(2-(tetrahydro-2H-pyran-4-yl)-2-azaspiro[3.3]heptan-6-yl)-1H-pyrazol-3-yl)propan-1-one, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(3-(perfluoroethyl)-1-(2-(tetrahydro-2H-pyran-4-yl)-2-azaspiro[3.3]heptan-6-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(3-isopropyl-1-(2-(4-methyltetrahydro-2H-pyran-4-yl)-2-azaspiro[3.3]heptan-6-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)\u2014N-(1-(2-(1,3-dioxan-5-yl)-2-azaspiro[3.3]heptan-6-yl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)pyrimidin-2-amine, or a salt thereof; (S)\u2014N-(1-(2-(1,4-dioxepan-6-yl)-2-azaspiro[3.3]heptan-6-yl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(3-(difluoromethoxy)-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; (S)-5-(3-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-chlorophenyl)-N-(3-isopropyl-1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine, or a salt thereof; and (S)-2-((1-(1H-tetrazol-1-yl)propan-2-yl)oxy)-4-(2-((1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-3-(2,2,2-trifluoroethoxy)-1H-pyrazol-4-yl)amino)pyrimidin-5-yl)benzonitrile, or a salt thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.35593
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15830634', '13201536', '14404126', '15563161', '15506380']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8594288176116747
- 35 USC 102 Novelty (BERT): 0.5636414487088672
- Combined Prediction Score: 0.8298500807213939
- Mean Citation Score: 428.920974
- Max Citation Score: 449.30573
- Similarity Product: 401.6878628807962

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test