PATENT CLAIM ANALYSIS

Application Number: 16362551
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["424", "093210"]

Abstract:
The present disclosure provides compositions and methods for targeting a minor histocompatibility (H) antigen (HA-1 H ) to, for example, prevent or manage relapse of a hematological malignancy after allogeneic hematopoietic stem cell transplantation (HCT). Also provided are transgene constructs encoding engineered binding proteins, such as a T cell receptor or a chimeric antigen receptor, optionally encoding additional components such as a co-receptor and/or safety switch. Such transgene constructs can be transduced into an immune cell, such as a T cell, and used as an immunotherapy in a subject having a hematological malignancy or at risk for recurrence of the hematological malignancy (e.g., leukemia, lymphoma, myeloma).

Claim (Index 9):
The engineered immune cell of  claim 1 , wherein the encoded binding protein comprises:\n (a) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 27, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 28; (b) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 29, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 30; (c) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 31, and the TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 32; (d) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 33, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 34; (e) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 35, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 36; (f) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 37, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 38; (g) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 108, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO:109; (h) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 110, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO:111; (i) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 112, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO:113; (j) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 114, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO:115; (k) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 116, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO:117; or (l) a TCR \u03b2-chain comprising or consisting of the amino acid sequence of SEQ ID NO: 118, and a TCR \u03b1-chain comprising or consisting of the amino acid sequence of SEQ ID NO:119.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 99.0
- Lexical Diversity: 1.64474
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14813782', '15006224', '13500123', '14830392', '15301686']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6879499621504305
- 35 USC 102 Novelty (BERT): 0.5376304919851308
- Combined Prediction Score: 0.6729180151339005
- Mean Citation Score: 297.5274
- Max Citation Score: 362.96222
- Similarity Product: 277.6836168374777

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test