PATENT CLAIM ANALYSIS

Application Number: 15914796
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "491000"]

Abstract:
A synthetic gene delivery platform with a dense surface coating of hydrophilic and neutrally charged PEG, capable of rapid diffusion and widespread distribution in brain tissue, and highly effective gene delivery to target cells therein has been developed. Nanoparticles including nucleic acids, are formed of a blend of biocompatible hydrophilic cationic polymers and they hydrophilic cationic polymer conjugated to hydrophilic neutrally charged polymers such as polyethylene glycol. The nanoparticles are coated with polyethylene glycol at a density that imparts a near neutral charge and optimizes rapid diffusion through the brain parenchyma. Methods of treating a disease or disorder of the brain including administering a therapeutically effective amount of nanoparticles densely coated with polyethylene glycol are also provided.

Claim (Index 16):
A dosage formulation for delivery of a therapeutic agent to the brain consisting of\n a therapeutically effective amount of the nanoparticles of  claim 1  for administration to the brain; and a pharmaceutically acceptable excipient for delivery into the brain.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 90.0
- Lexical Diversity: 1.61039
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15310535', '15310643', '15759465', '13984386', '13821320']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7887882817404906
- 35 USC 102 Novelty (BERT): 0.6723561169954447
- Combined Prediction Score: 0.7771450652659861
- Mean Citation Score: 444.95454200000006
- Max Citation Score: 735.8756
- Similarity Product: 643.1627842083452

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test