PATENT CLAIM ANALYSIS

Application Number: 15902802
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "456000"]

Abstract:
The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Claim (Index 10):
A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:\n 6-bromo-N-(naphthalene-1-sulfonyl)-4-phenyl-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (2R,4R)-2-[(ethylsulfanyl)methyl]-N-(naphthalene-1-sulfonyl)-4-phenyl-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 6-methoxy-2,2-dimethyl-N-(naphthalene-1-sulfonyl)-4-phenyl-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 6-methoxy-N-(naphthalene-1-sulfonyl)-4-phenyl-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 6-benzoyl-5,7-dimethyl-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; N-(naphthalene-1-sulfonyl)-3-phenyl-2,3-dihydro-1-benzofuran-3-carboxamide; 8-chloro-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 3-ethyl-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 4-ethyl-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 8-bromo-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 6,8-dibromo-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 8-cyclobutyl-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 8-cyclopentyl-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 3-ethyl-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 2-methyl-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1-benzofuran-2-carboxamide; N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1-benzofuran-2-carboxamide; 6-methyl-N-(naphthalene-1-sulfonyl)-4-phenyl-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 6-chloro-N-(naphthalene-1-sulfonyl)-4-phenyl-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 7-bromo-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 7-bromo-3-ethyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 3-ethyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 2-methyl-N-[4-(propan-2-yl)benzene-1-sulfonyl]-2,3-dihydro-1-benzofuran-2-carboxamide; 5-chloro-N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 5-chloro-N-(propane-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; N-(2-methylbenzene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; N-(2-methylbenzene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (2S)\u2014N-(naphthalene-1-sulfonyl)-4-phenyl-2-[(pyrrolidin-1-yl)methyl]-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (7S)-2,2-difluoro-7-methyl-N-(naphthalene-1-sulfonyl)-6,7-dihydro-2H-furo[2,3-f][1,3]benzodioxole-7-carboxamide; (7R)-2,2-difluoro-7-methyl-N-(naphthalene-1-sulfonyl)-6,7-dihydro-2H-furo[2,3-f][1,3]benzodioxole-7-carboxamide; N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (4S)-8-bromo-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-bromo-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 4-bromo-7-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydrospiro[1-benzopyran-2,1\u2032-cyclohexane]-4-carboxamide; 7-bromo-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 4-methoxy-N-(naphthalene-1-sulfonyl)-5-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-carboxamide and 4-methoxy-N-(naphthalene-1-sulfonyl)-7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 8-bromo-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydrospiro[1-benzopyran-2,1\u2032-cyclohexane]-4-carboxamide; 8-bromo-5-methoxy-N-(quinoline-8-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 7-chloro-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 7-chloro-3-ethyl-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; N-(naphthalene-1-sulfonyl)-7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 8-bromo-5-methoxy-2,2-dimethyl-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 5-methoxy-2,2-dimethyl-N-(quinoline-8-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 5-methoxy-2,2-dimethyl-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 5-methoxy-2,2-dimethyl-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 8-cyano-5-methoxy-2,2-dimethyl-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 8-chloro-5-methoxy-2,2-dimethyl-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 8-bromo-5-methoxy-2,2-dimethyl-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-8-(trifluoromethyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 8-cyclobutyl-5-methoxy-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4S)-8-cyclobutyl-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-cyclobutyl-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4S)-5-methoxy-N-(naphthalene-1-sulfonyl)-8-(trifluoromethyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-5-methoxy-N-(naphthalene-1-sulfonyl)-8-(trifluoromethyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4S)-8-cyclobutyl-5-methoxy-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-cyclobutyl-5-methoxy-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 3-ethyl-N-(naphthalene-1-sulfonyl)-7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 4,7-dimethoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 7-chloro-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 8-cyclopropyl-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (3S)-7-cyclobutyl-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (3R)-7-cyclobutyl-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (3R)-7-chloro-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (3S)-7-chloro-4-methoxy-N-(naphthalene-1-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (4S)-8-bromo-5-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-bromo-5-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4S)-8-bromo-5-methoxy-2,2-dimethyl-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-bromo-5-methoxy-2,2-dimethyl-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (3R)-7-bromo-4-methoxy-N-(1-naphthylsulfonyl)-2,3-dihydrobenzofuran-3-carboxamide; (3S)-7-bromo-4-methoxy-N-(1-naphthylsulfonyl)-2,3-dihydrobenzofuran-3-carboxamide; 8-cyclobutyl-5-methoxy-N-(2-methylquinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4S)-8-cyclobutyl-5-methoxy-N-(2-methylquinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-cyclobutyl-5-methoxy-N-(2-methylquinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 5-bromo-8-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-1H-2-benzopyran-1-carboxamide; 5-cyclobutyl-8-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-1H-2-benzopyran-1-carboxamide; 7-cyclobutyl-4-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 5-cyclobutyl-8-methoxy-N-(quinoline-5-sulfonyl)-3,4-dihydro-1H-2-benzopyran-1-carboxamide; (3R)-7-cyclobutyl-4-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (3S)-7-cyclobutyl-4-methoxy-N-(quinoline-5-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 5-cyclobutyl-8-methoxy-1-methyl-N-(naphthalene-1-sulfonyl)-3,4-dihydro-1H-2-benzopyran-1-carboxamide; 8-cyclobutyl-5-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-cyclobutyl-5-methoxy-2,2-dimethyl-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 7-cyclobutyl-4-methoxy-N-(1-methyl-1H-benzimidazole-7-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 7-cyclobutyl-4-methoxy-N-(pyrazolo[1,5-a]pyridine-4-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 7-cyclobutyl-4-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 7-cyclobutyl-4-methoxy-N-(1,2,3,4-tetrahydroquinoline-8-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (4S)-8-cyclobutyl-5-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-cyclobutyl-5-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 8-cyclobutyl-5-methoxy-2,2-dimethyl-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (3R)-7-cyclobutyl-4-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (3S)-7-cyclobutyl-4-methoxy-N-(1-methyl-1H-indazole-7-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (4S)-8-cyclobutyl-5-methoxy-2,2-dimethyl-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-cyclobutyl-5-methoxy-2,2-dimethyl-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (3R)-7-cyclobutyl-4-methoxy-N-(1,2,3,4-tetrahydroquinoline-8-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (3S)-7-cyclobutyl-4-methoxy-N-(1,2,3,4-tetrahydroquinoline-8-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (3R)-7-cyclobutyl-4-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; (3S)-7-cyclobutyl-4-methoxy-N-(1,2,3,4-tetrahydroquinoline-5-sulfonyl)-2,3-dihydro-1-benzofuran-3-carboxamide; 8-cyclobutyl-N-(1H-indole-4-sulfonyl)-5-methoxy-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4S)-8-cyclobutyl-N-(1H-indole-4-sulfonyl)-5-methoxy-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-8-cyclobutyl-N-(1H-indole-4-sulfonyl)-5-methoxy-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 5-cyclobutyl-8-methoxy-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4R)-5-cyclobutyl-8-methoxy-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; (4S)-5-cyclobutyl-8-methoxy-N-(quinoline-5-sulfonyl)-3,4-dihydro-2H-1-benzopyran-4-carboxamide; 8-bromo-5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-1H-2-benzopyran-1-carboxamide; N-(naphthalene-1-sulfonyl)-7-(trifluoromethoxy)-3,4-dihydro-1H-2-benzopyran-1-carboxamide; 5-methoxy-N-(naphthalene-1-sulfonyl)-3,4-dihydro-1H-2-benzopyran-1-carboxamide; and pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 88.0
- Lexical Diversity: 1.41379
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14880834', '13294303', '14780018', '10590975', '14207854']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8387017765624312
- 35 USC 102 Novelty (BERT): 0.5311891305293959
- Combined Prediction Score: 0.8079505119591277
- Mean Citation Score: 358.872212
- Max Citation Score: 368.05652
- Similarity Product: 281.0112974589896

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test