PATENT CLAIM ANALYSIS

Application Number: 15895872
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "043000"]

Abstract:
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.

Claim (Index 1):
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: B 1A  is an optionally substituted heterocyclic base or an optionally substituted heterocyclic base with a protected amino group; R A  is hydrogen or deuterium; R 1A  is selected from the group consisting of hydrogen, an optionally substituted acyl, an optionally substituted O-linked amino acid, R a1  and R a2  are independently hydrogen or deuterium; R 2A  is a C 1-6  azidoalkyl or a C 1-6  aminoalkyl; R 3A  is selected from the group consisting of OH, \u2014OC(\u2550O)R\u2033 A  and an optionally substituted O-linked amino acid; R 4A  is halogen; R 5A  is hydrogen or halogen; R 6A , R 7A  and R 8A  are independently selected from the group consisting of absent, hydrogen, an optionally substituted C 1-24  alkyl, an optionally substituted C 3-24  alkenyl, an optionally substituted C 3-24  alkynyl, an optionally substituted C 3-6  cycloalkyl, an optionally substituted C 3-6  cycloalkenyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aryl(C 1-6  alkyl), an optionally substituted *\u2014(CR 15A R 16A ) p \u2014O\u2014C 1-24  alkyl, an optionally substituted *\u2014(CR 17A R 18A ) p \u2014O\u2014C 1-24  alkenyl, or R 6A  is and R 7A  is absent or hydrogen; or R 6A  and R 7A  are taken together to form a moiety selected from the group consisting of an optionally substituted and an optionally substituted wherein the oxygens connected to R 6A  and R 7A , the phosphorus and the moiety form a six-membered to ten-membered ring system; R 9A  is independently selected from the group consisting of an optionally substituted C 1-24  alkyl, an optionally substituted C 2-24  alkenyl, an optionally substituted C 2-24  alkynyl, an optionally substituted C 3-6  cycloalkyl, an optionally substituted C 3-6  cycloalkenyl, NR 30A R 31A , an optionally substituted N-linked amino acid and an optionally substituted N-linked amino acid ester derivative; R 10A  and R 11A  are independently an optionally substituted N-linked amino acid or an optionally substituted N-linked amino acid ester derivative; R 12A , R 13A  and R 14A  are independently absent or hydrogen; each R 15A , each R 16A , each R 17A  and each R 18A  are independently hydrogen, an optionally substituted C 1-24  alkyl or alkoxy; R 19A , R 20A , R 22A  and R 23A  are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24  alkyl and an optionally substituted aryl; R 21A  and R 24A  are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24  alkyl, an optionally substituted aryl, an optionally substituted \u2014O\u2014C 1-24  alkyl, an optionally substituted \u2014O-aryl an optionally substituted \u2014O-heteroaryl, an optionally substituted \u2014O-monocyclic heterocyclyl and R 25A  and R 29A  are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24  alkyl and an optionally substituted aryl; R 26A  and R 27A  are independently \u2014C\u2261N or an optionally substituted substituent selected from the group consisting of C 2-8  organylcarbonyl, C 2-8  alkoxycarbonyl and C 2-8  organylaminocarbonyl; R 28A  is selected from the group consisting of hydrogen, an optionally substituted C 1-24 -alkyl, an optionally substituted C 2-24  alkenyl, an optionally substituted C 2-24  alkynyl, an optionally substituted C 3-6  cycloalkyl and an optionally substituted C 3-6  cycloalkenyl; R 30A  and R 31A  are independently selected from the group consisting of hydrogen, an optionally substituted C 1-24 -alkyl, an optionally substituted C 2-24  alkenyl, an optionally substituted C 2-24  alkynyl, an optionally substituted C 3-6  cycloalkyl and an optionally substituted C 3-6  cycloalkenyl; R\u2033 A  is an optionally substituted C 1-24 -alkyl; m and t are independently 0 or 1; p and q are independently selected from the group consisting of 1, 2 and 3; r is 1 or 2; s is 0, 1, 2 or 3; u is 1 or 2; and Z 1A , Z 2A , Z 3A  and Z 4A  are independently O or S.

Metadata:
- Claim Count in Document: 30.0
- Percentile: 88.0
- Lexical Diversity: 1.58333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14312990', '13721988', '15215434', '13236486', '14386294']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8352333770673079
- 35 USC 102 Novelty (BERT): 0.532400098587237
- Combined Prediction Score: 0.8049500492193008
- Mean Citation Score: 358.02125000000007
- Max Citation Score: 369.378
- Similarity Product: 340.7846535669565

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test