PATENT CLAIM ANALYSIS

Application Number: 15982926
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-04
Patent Classification: ["436", "180000"]

Abstract:
A system for determining drug effectiveness on a plurality of cells is described. The system includes flowing a ferrofluid mixed with a plurality of biological cells through an inlet portion of a cartridge, the cartridge comprising a plurality of microfluidic channels, the inlet is in communication with a portion of each of the plurality of channels, applying a magnetic field proximate at least one of the inlet portion and the plurality of micro-channels, wherein the magnetic field is configured to apply an indirect force on the mix, separating biologic cells according to at least a first type as the mix flows in a first direction; and directing at least the first type of cells toward a first sensor functionalized with receptors via at least one of the micro-channels, the sensor arranged proximate to a second portion of at least one of the micro-channels downstream from the first inlet portion.

Claim (Index 23):
A system for determining drug effectiveness on a plurality of cells comprising:\n a cartridge comprising a plurality of micro-channels; an inlet receiving a ferrofluid and biological cell mixture, the inlet in communication with at least one of the plurality of micro-channels; a magnetic field source arranged proximate to at least one of the inlet and the plurality of micro-channels; at least one receptor region having receptors for binding with at least a first type of biological cell, the at least one receptor region arranged proximate to a first portion of at least one of the micro-channels, wherein the first portion is downstream from the inlet; at least one quartz-crystal-microbalance (QCM) sensor arranged proximate to the first portion of at least one of the micro-channels; and a controller; wherein:\n the magnetic field source generates a magnetic field that applies a force on the mixture so as to separate at least biological cells of the first type from the mixture, \n at least a first micro-channel of the plurality of micro-channels receives biological cells of the first type and directs the first type of cells to the at least one receptor region, \n each of the plurality of micro-channels receives a dosage of a drug to interact with the first type of biological cell captured by the receptors, and \n the controller has computer instructions operating thereon to cause the controller to determine, using the at least one QCM sensor:\n a first mass corresponding to the first type of cells captured by the receptors before the drug is received, and \n a second mass corresponding to the first type of cells after the drug interacts with the first type of cells captured by the receptors.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 93.0
- Lexical Diversity: 2.28986
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13878935', '14318364', '10416418', '15740288', '11409600']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6323103110023398
- 35 USC 102 Novelty (BERT): 0.4700774090381255
- Combined Prediction Score: 0.6160870208059184
- Mean Citation Score: 126.17593200000002
- Max Citation Score: 137.44096000000002
- Similarity Product: 87.89667547710421

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test