PATENT CLAIM ANALYSIS

Application Number: 16360811
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-09
Patent Classification: ["514", "235800"]

Abstract:
Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.

Claim (Index 2):
The compound of formula (I) according to  claim 1 , wherein:\n R 1  is hydrogen, halogen, 1-3C-alkyl, R 2 /R 3  are independently from each other hydrogen, halogen, cyano, 1-6C-haloalkyl, 1-6C-haloalkoxy, R 4  is independently hydrogen, halogen, cyano, 1-6C-alkyl, 2-6C-alkenyl, 1-6C-haloalkyl, 1-6C-hydroxyalkyl, 1-6C-alkoxy, 1-6C-haloalkoxy, \u2014C(O)OR 9 , -(1-6C-alkylen)-C(O)OR 9 , \u2014C(O)-(1-6C-alkyl), \u2014C(O)NR 10 R 11 , 3-7C-cycloalkyl, \u2014S-(1-6C-haloalkyl), SF 5 , \u2014SO 2 NH-(3-7-cycloalkyl), \u2014SO 2 NR 10 R 11 ,\n heteroaryl which optionally is substituted independently one or more times with cyano, 1-4C-alkyl, 1-6C-haloalkyl, 1-6C-haloalkoxy, C(O)OR 9 , C(O)NR 10 R 11 , \n whereby two of R 2 , R 3 (R 4 ) n , when positioned ortho to each other, may form together with the two carbon atoms to which they are attached, a heterocyclic 5-, 6- or 7-membered ring containing 1 or 2 heteroatoms selected from O or N, and optionally an additional double bond and/or a carbonyl group and/or an 1-4C-alkyl group, \n n 0-3 R 6  is (a) hydrogen;\n (b) hydroxy; \n (c) cyano; \n (d) 1-6C-alkoxy opt. subst. with\n (d1) 1-2 OH, \n (d2) NR 10 R 11 , \n (d3) SO 2 NR 10 R 11 , \n (d4) heterocyclyl, \n (d5) heteroaryl, which is optionally substituted independently one or more times with cyano, 1-4Calkyl, 1-6C-haloalkyl, 1-6C-haloalkoxy, C(O)OR 9 , C(O)NR 10 R 11 , \n \n (e) SO 2 NR 10 R 11 ; \n (f) 3-7C-cycloalkoxy, \n (g) 1-6C-haloalkoxy, \n (h) \u2014C(O)NR 10 R 11 , \n (i) \u2014O-heteroaryl opt. subst. with CN \n \u2003whereby the * is the point of attachment, R 7  is\n (a) hydrogen, \n (b) 1-6C-alkyl, which is optionally substituted with heteroaryl \n (c) 1-6C-haloalkyl, \n (d) 1-6C-hydroxyalkyl, \n \u2003whereby the * is the point of attachment, (f) \u2014C(O)-(1-6C-alkyl) (g) \u2014C(O)-(1-6C-alkylen)-O-(1-6C-alkyl) (h) \u2014C(O)-(1-6C-alkylen)-O-(1-6C-alkylen)-O-(1-6C-alkyl) (i) \u2014C(O)-heterocyclyl, (j) benzyl whereby the phenyl ring is opt. subst with 1-5 substituents independently selected from the group consisting of\n hydrogen, halogen, 1-4Calkyl, 1-4C-haloalkyl, 1-4C-alkoxy, 1-4C-haloalkoxy, cyano, C(O)OR 9 , \n (k) heteroaryl or optionally R 6  and R 7  together with the nitrogen atom to which they are attached form a 6-membered ring which may contain one further heteroatom selected from the group consisting of O, S, N,\n and which is optionally substituted by hydroxy-(1-6alkyl), \n R 8  is hydrogen, halogen, cyano, 1-6C-haloalkyl, 1-6C-haloalkoxy, C(O)OR 9 , C(O)NR 11 R 11 , m is 0-4 R 9  is (a) hydrogen,\n (b) 1-6C-alkyl which optionally may be substituted with hydroxy, \n R 10 , R 11  are independently from each other hydrogen, 1-4C-alkyl, 1-4C-hydroxyalkyl, 1-4C-alkoxy, or\n together with the nitrogen atom to which they are attached form a 5-6-membered heterocyclic ring optionally containing one further heteroatom selected from the group consisting of O, S or N, \n or an N-oxide, a salt, a tautomer or a stereoisomer thereof, or a salt of said N-oxide, tautomer or stereoisomer.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 99.0
- Lexical Diversity: 1.09091
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14350160', '14365895', '14400315', '14900599', '15032957']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.842185244097478
- 35 USC 102 Novelty (BERT): 0.622300481663604
- Combined Prediction Score: 0.8201967678540906
- Mean Citation Score: 480.713422
- Max Citation Score: 558.1653
- Similarity Product: 547.5930993119896

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test