PATENT CLAIM ANALYSIS

Application Number: 16119501
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["424", "186100"]

Abstract:
Described herein is the generation of optimized HIN1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2011. Provided herein are optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.

Claim (Index 3):
The influenza VLP of  claim 1 , further comprising an influenza neuraminidase (NA) protein, an influenza matrix (M1) protein, or both.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 96.0
- Lexical Diversity: 1.65625
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14126550', '15392710', '15051991', '14092371', '15407502']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7766273202628353
- 35 USC 102 Novelty (BERT): 0.579660113565711
- Combined Prediction Score: 0.7569305995931229
- Mean Citation Score: 500.358418
- Max Citation Score: 510.4525
- Similarity Product: 382.8439388009906

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test