PATENT CLAIM ANALYSIS

Application Number: 16399991
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["703", "011000"]

Abstract:
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

Claim (Index 7):
The method of  claim 5 , wherein the reverse primers are selected by identifying primer pairs likely to form undesired primer duplexes and removing from the plurality of primers at least one of the pair of primers identified as being likely to form undesired primer duplexes.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 100.0
- Lexical Diversity: 2.01316
- Patent Class: 703.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13791397', '13300235', '15917383', '16399103', '16399268']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.2551571925025138
- 35 USC 102 Novelty (BERT): 0.6062973792903276
- Combined Prediction Score: 0.2902712111812952
- Mean Citation Score: 508.35367
- Max Citation Score: 571.4026
- Similarity Product: 442.3384226696372

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test