PATENT CLAIM ANALYSIS

Application Number: 15899834
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["435", "122000"]

Abstract:
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Claim (Index 8):
A process for preparing an amine compound of formula (III), wherein (a) R 1  and R 2  groups are independently selected from the group consisting of a hydrogen atom, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted alkoxy, an optionally substituted carboxy, an optionally substituted aminocarbonyl, an optionally substituted heteroalkyl, an optionally substituted heteroalkenyl, an optionally substituted heteroalkynyl, an optionally substituted carboxyalkyl, an optionally substituted aminoalkyl, an optionally substituted haloalkyl, an optionally substituted alkylthioalkyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted arylalkyl, an optionally substituted heterocycloalkyl, an optionally substituted heteroaryl, and an optionally substituted heteroarylalkyl; (b) R 1  and R 2  are linked to form a 3-membered to 10-membered ring; (c) R 3  and R 4  groups are independently selected from a hydrogen atom, and optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted alkoxy, an optionally substituted carboxy, an optionally substituted aminocarbonyl an optionally substituted heteroalkyl, an optionally substituted heteroalkenyl, an optionally substituted heteroalkynyl, an optionally substituted carboxyalkyl, an optionally substituted aminoalkyl, an optionally substituted haloalkyl, an optionally substituted alkylthioalkyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted arylalkyl, an optionally substituted heterocycloalkyl, an optionally substituted heteroaryl, and an optionally substituted heteroarylalkyl, with the proviso that both R 3  and R 4  cannot be hydrogen; (d) R 3  and R 4  are linked to form a 3-membered to 10-membered ring; or (e) and at least one of R 1  and R 2  is linked to at least one of R 3  and R 4 ; wherein optionally, the carbon atom and/or the nitrogen indicated by * is chiral; the process comprising contacting a compound of formula (I), wherein R 1 , and R 2  are as defined above; and\n a compound of formula (II), \n wherein R 3 , and R 4  are as defined above; with an engineered polypeptide having imine reductase activity in presence of a cofactor under suitable reaction conditions, wherein the engineered polypeptide is the engineered polypeptide of  claim 1 .

Metadata:
- Claim Count in Document: 12.0
- Percentile: 88.0
- Lexical Diversity: 1.43243
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13890944', '15710462', '15048887', '15605061', '14887943']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8357427209000596
- 35 USC 102 Novelty (BERT): 0.8135139060206256
- Combined Prediction Score: 0.8335198394121163
- Mean Citation Score: 1070.77044
- Max Citation Score: 1083.2335
- Similarity Product: 1064.2635667185784

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test