PATENT CLAIM ANALYSIS

Application Number: 16044752
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["544", "106000"]

Abstract:
The present invention relates to compounds that act as pan-Rac inhibitors, compositions including the compounds, and methods of using the compounds. In particular, the compounds are useful for treating certain cancers such as breast cancer.

Claim (Index 11):
A compound of  claim 1  selected from the following:\n 4-({1-[4-({[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}methyl)phenyl]-1H-imidazol-4-yl}methyl) piperazin-2-one; \n 4-[({4-[4-(piperazin-1-ylmethyl)-1H-imidazol-1-yl]phenyl}methyl)sulfanyl]-7-(trifluoromethyl) quinoline; \n 4-[({4-[4-(morpholin-4-ylmethyl)-1H-imidazol-1-yl]phenyl}methyl)sulfanyl]-7-(trifluoromethyl)quinoline; \n 4-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}morpholin-3-one; \n 4-({6-[3-(morpholine-4-carbonyl)pyrrolidin-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 1 tert-butyl 4-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)piperazine-1-carboxylate; \n 1-[3-(morpholin-4-ylmethyl)pyrrolidin-1-yl]-6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexan-1-one; \n 4-({6-[4-(oxan-4-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 4-[(6-{4-[(3-methylpiperazin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}hexyl)sulfanyl]-7-(trifluoromethyl)quinoline; \n 4-methoxy-N-methyl-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methyl}aniline; \n 1-{4-[(1-{6-[(7-fluoroquinolin-4-yl)sulfanyl]hexyl}-1H-imidazol-4-yl)methyl]piperazin-1-yl}-2-methylpropan-1-one; \n 4-[(6-{4-[(4,4-difluoropiperidin-1-yl)methyl]-1H-imidazol-1-yl}hexyl)sulfanyl]-7-(trifluoromethyl)quinoline; \n 7-(trifluoromethyl)-4-{[6-(4-{[4-(trifluoromethyl)piperidin-1-yl]methyl}-1H-imidazol-1-yl) hexyl]sulfanyl}quinoline; \n 4-{[6-(4-phenyl-1H-imidazol-1-yl)hexyl]sulfanyl}-7-(trifluoromethyl)quinoline; \n 4-phenyl-1-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methyl}piperidin-4-ol; \n 4-(piperazin-1-yl)-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methyl}aniline; \n 7-fluoro-4-({6-[4-(morpholin-4-ylmethyl)-1H-imidazol-1-yl]hexyl}sulfanyl)quinoline; \n 4-[(6-{4-[1-(morpholin-4-yl)ethyl]-1H-imidazol-1-yl}hexyl)sulfanyl]-7-(trifluoromethyl) quinoline; \n phenyl[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methanol; \n N-[(1-{6-[(7-fluoroquinolin-4-yl)sulfanyl]hexyl}-1H-imidazol-4-yl)methyl]aniline; \n 4-[(1-{6-[(7-fluoroquinolin-4-yl)sulfanyl]hexyl}-1H-imidazol-4-yl)methyl]piperazin-2-one; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}pyridin-3-amine; \n 4-({6-[4-(piperidin-1-ylmethyl)-1H-imidazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 4-({6-[4-(piperidin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl) quinoline; \n 4-({6-[6-(morpholin-4-ylmethyl)pyridin-3-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}pyridin-2-amine; \n N-methyl-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}pyrazine-2-carboxamide; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}oxetan-3-amine; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}oxan-3-amine; \n (1-methoxypropan-2-yl)({[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl})amine; \n (1-methoxy-2-methylpropan-2-yl)({[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl})amine; \n 4-[(6-{4-[(3-methoxyazetidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}hexyl)sulfanyl]-7-(trifluoromethyl)quinoline; \n (2-methoxy-2-methylpropyl)({[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl})amine; \n 4-{[6-(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-1H-1,2,3-triazol-1-yl)hexyl]sulfanyl}-7-(trifluoromethyl)quinoline; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}pyrazine-2-carboxamide; \n 4-[(6-{4-[(3-methoxypyrrolidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}hexyl)sulfanyl]-7-(trifluoromethyl)quinoline; \n 7,8-difluoro-4-({6-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)quinoline; \n 5,7-difluoro-4-({6-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)quinoline; \n 1-(4-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}piperidin-1-yl)ethan-1-one; \n 4-{[6-(4-{[4-(oxane-4-carbonyl)piperazin-1-yl]methyl}-1H-1,2,3-triazol-1-yl)hexyl]sulfanyl}-7-(trifluoromethyl)quinoline; \n 2-methyl-1-(4-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}piperazin-1-yl)propan-1-one; \n 1-(4-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}piperazin-1-yl)ethan-1-one; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}pyridine-2-carboxamide; \n 4-({6-[4-(cyclohexylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}oxane-4-carboxamide; \n 4-[(6-{4-[2-(morpholin-4-yl)ethyl]-1H-1,2,3-triazol-1-yl}hexyl)sulfanyl]-7-(trifluoromethyl) quinoline; \n 4-({6-[5-(morpholin-4-ylmethyl)-1H-pyrazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 4-({6-[3-(morpholin-4-ylmethyl)-1H-pyrazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}cyclohexanecarboxamide; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}benzamide; \n N-methyl-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methyl}aniline; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methyl}aniline; \n 4-methoxy-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methyl}aniline; \n 4-methyl-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methyl}aniline; \n (2-methoxyethyl)(methyl){[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methyl}amine; \n 4-({6-[4-(1,4-diazepan-1-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl) quinoline; \n 4-({6-[4-(piperidin-1-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl) quinoline; \n 4-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}piperazin-2-one; \n 4-({6-[4-(morpholin-4-ylmethyl)-1H-pyrazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n diethyl({[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}) amine; \n 4-({6-[3-(morpholin-4-ylmethyl)-1,2,4-oxadiazol-5-yl]hexyl}sulfanyl)-7-(trifluoromethyl) quinoline; \n 7-chloro-4-({6-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)quinoline; \n 7-fluoro-4-({6-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)quinoline; \n 4-({6-[4-(piperazin-1-ylmethyl)-1H-imidazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n (2-methoxyethyl)({[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-imidazol-4-yl]methyl})amine; \n 4-({6-[5-(morpholin-4-ylmethyl)-1,3,4-oxadiazol-2-yl]hexyl}sulfanyl)-7-(trifluoromethyl) quinoline; \n 7-methyl-4-({6-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)quinoline; \n N-(2-methoxyethyl)-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}acetamide; \n (2-methoxyethyl)(methyl){[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}amine; \n 4-[(6-{4-[(4-methylpiperazin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}hexyl)sulfanyl]-7-(trifluoromethyl)quinoline; \n 4-({6-[4-(piperazin-1-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 4-{[(3-{[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]methyl}phenyl)methyl]sulfanyl}-7-(trifluoromethyl)quinoline; \n 4-methyl-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}aniline; \n 4-methoxy-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}aniline; \n N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}aniline; \n 4-({6-[5-(morpholin-4-ylmethyl)-1H-imidazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl) quinoline; \n 4-({6-[4-(morpholin-4-ylmethyl)-1H-imidazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl) quinoline; \n N-{6-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}-7-(trifluoromethyl)quinolin-4-amine; \n (2-methoxyethyl)({[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl})amine; \n 1 tert-butyl N-(2-methoxyethyl)-N-{[1-(6-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}hexyl)-1H-1,2,3-triazol-4-yl]methyl}carbamate; \n methyl({2-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]ethyl})(3-{[7-(trifluoromethyl) quinolin-4-yl]sulfanyl}propyl)amine; \n 4-[(3-{3-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]propoxy}propyl)sulfanyl]-7-(trifluoromethyl)quinoline; \n 4-[(3-{2-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]ethoxy}propyl)sulfanyl]-7-(trifluoromethyl)quinoline; \n 4-({7-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]heptyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 4-({6-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]hexyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 4-({3-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]propyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 4-({4-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]butyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 4-({5-[4-(morpholin-4-ylmethyl)-1H-1,2,3-triazol-1-yl]pentyl}sulfanyl)-7-(trifluoromethyl)quinoline; \n 4-[(5-{[6-(morpholin-4-ylmethyl)pyridin-3-yl]oxy}pentyl)sulfanyl]-7-(trifluoromethyl)quinoline; \n diethyl({5-[(5-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}pentyl)oxy]pyridin-2-yl}methyl) amine; and \n 4-[[1-[[4-[[7-(trifluoromethyl)-4-quinolyl]sulfanylmethyl]phenyl]methyl]imidazol-4-yl]methyl]morpholine.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 95.0
- Lexical Diversity: 1.29032
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['10894940', '15266411', '12394072', '15499443', '13822809']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.829667421877994
- 35 USC 102 Novelty (BERT): 0.5313674137823603
- Combined Prediction Score: 0.7998374210684306
- Mean Citation Score: 354.313954
- Max Citation Score: 371.0986
- Similarity Product: 272.2914247597694

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test