PATENT CLAIM ANALYSIS

Application Number: 16049713
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-07
Patent Classification: ["264", "308000"]

Abstract:
In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e.g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e.g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e.g., a drug) or a reagent, and/or amount of the compound (e.g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.

Claim (Index 1):
A method for three-dimensional printing of an oral drug dosage form formulated and configured to provide a desired drug release profile, wherein the drug dosage form comprises a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a drug having a pre-determined drug mass faction (m F ), wherein the first erodible material is embedded in a second material not admixed with the drug, the method comprising:\n (a) dividing the desired drug release profile into a plurality of time intervals (t n ), each time interval corresponding to a layer in the multi-layered structure; (b) calculating the percentage of drugs to be released during each time interval (% L ); (c) calculating the thickness of each layer (H n ) of the multi-layered structure based on the erosion rate of the first erodible material(V), wherein H n =t n *V; (d) calculating the surface area of each layer based on % L , H n , m F , total amount of drug in the oral drug dosage form (m DTot ), and the density of the first erodible material (\u03c1), wherein: S n = % L * m DTot \u03c1 * Hn * m F ; (e) dispensing the first erodible material admixed with the drug based on the determined H n  and S n  for each layer, thereby printing the multi-layered structure; (f) before, after, or during step (e), dispensing the second material not admixed with the drug.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 2.67213
- Patent Class: 264.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15173596', '16028305', '11321736', '11876153', '13625658']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7641206241159846
- 35 USC 102 Novelty (BERT): 0.48519680889224
- Combined Prediction Score: 0.7362282425936101
- Mean Citation Score: 198.336352
- Max Citation Score: 209.11444
- Similarity Product: 152.71405884028195

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test