PATENT CLAIM ANALYSIS

Application Number: 16075240
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["514", "315000"]

Abstract:
Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.

Claim (Index 8):
The compound according to  claim 1 , wherein R 1  is\n (1) a hydrogen atom, (2) a C 1-6  alkyl-carbonyl group optionally substituted by 1 to 7 substituents selected from (i) a halogen atom, (ii) a cyano group, (iii) a hydroxy group, (iv) a C 3-10  cycloalkyl group, (v) a C 1-6  alkoxy group, (vi) a C 6-14  aryl group, (vii) a C 6-14  aryloxy group, (viii) a pyrazolyl group, a thiazolyl group, a pyrimidinyl group or a pyridazinyl group, each of which is optionally substituted by an oxo group, (ix) a pyrazolyloxy group optionally substituted by 1 to 3 C 1-6  alkyl groups, (x) a C 1-6  alkyl-carbonyl group, (xi) a C 1-6  alkoxy-carbonyl group, (xii) a C 1-6  alkyl-carbonyloxy group, (xiii) a C 1-6  alkylsulfonyl group, (xiv) a mono- or di-C 1-6  alkylamino group, (xv) a C 1-6  alkyl-carbonylamino group and (xvi) a (C 1-6  alkyl) (C 1-6  alkyl-carbonyl)amino group, (3) a C 3-10  cycloalkyl-carbonyl group optionally substituted by 1 to 3 substituents selected from a halogen atom, a cyano group, a hydroxy group, an oxo group and a C 1-6  alkyl group, (4) a C 1-6  alkoxy-carbonyl group optionally substituted by 1 to 6 substituents selected from deuterium, a halogen atom and a C 6-14  aryl group, (5) a C 3-10  cycloalkyloxy-carbonyl group optionally substituted by 1 to 3 substituents selected from a C 1-6  alkyl group, (6) a C 6-14  aryl-carbonyl group optionally substituted by 1 to 3 substituents selected from a halogen atom and a C 6-14  aryl group, (7) a C 6-14  aryloxy-carbonyl group, (8) a furylcarbonyl group, a thienylcarbonyl group, a pyrazolylcarbonyl group, an isoxazolylcarbonyl group or a pyridylcarbonyl group, each of which is optionally substituted by 1 to 3 substituents selected from a C 1-6  alkyl group, (9) an azetidinylcarbonyl group, an oxetanylcarbonyl group, a pyrrolidinylcarbonyl group, a tetrahydrofuranylcarbonyl group, a tetrahydropyranylcarbonyl group or a morpholinylcarbonyl group, each of which is optionally substituted by 1 to 3 substituents selected from an oxo group, a C 1-6  alkyl-carbonyl group, a C 1-6  alkoxy-carbonyl group and a C 1-6  alkylsulfonyl group, (10) a mono- or di-C 1-6  alkyl-carbamoyl group optionally substituted by 1 to 3 substituents selected from a halogen atom, a cyano group, a hydroxy group and a C 1-6  alkoxy group, (11) a mono- or di-C 3-10  cycloalkyl-carbamoyl group, (12) a mono- or di-C 6-14  aryl-carbamoyl group, (13) a C 1-6  alkylsulfonyl group, (14) a C 3-10  cycloalkylsulfonyl group, (15) a C 6-14  arylsulfonyl group optionally substituted by 1 to 3 halogen atoms, (16) a thienylsulfonyl group, a pyrazolylsulfonyl group, an imidazolylsulfonyl group, a pyridylsulfonyl group or a dihydrochromenylsulfonyl group, each of which is optionally substituted by 1 to 3 substituents selected from a C 1-6  alkyl group, (17) a mono- or di-C 1-6  alkyl-sulfamoyl group or (18) a C 1-6  alkyl-carbonyl-carbonyl group;\n R 2  is a C 3-6  cycloalkyl group, a pyrrolidinyl group, a piperidinyl group or a dioxanyl group, each of which is optionally substituted by 1 to 3 substituents selected from \n (1) deuterium, (2) a halogen atom, (3) a hydroxy group, (4) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from a halogen atom and a C 6-14  aryl group, (5) a C 3-10  cycloalkyl group, (6) a C 1-6  alkoxy group optionally substituted by a C 3-10  cycloalkyl group, (7) a C 6-14  aryl group optionally substituted by 1 to 3 substituents selected from a halogen atom, a cyano group, a C 1-6  alkyl group optionally substituted by 1 to 3 halogen atoms, a C 1-6  alkoxy group optionally substituted by 1 to 3 halogen atoms and a hydroxy group, (8) a C 6-14  aryloxy group, (9) a tri-C 1-6  alkylsilyloxy group, (10) a pyrazolyl group, a thiazolyl group, a pyridyl group, a pyrimidinyl group, a quinazolinyl group, a benzothiazolyl group or an isoquinolinyl group, each of which is optionally substituted by 1 to 3 substituents selected from a halogen atom, a C 1-6  alkyl group and a C 1-6  alkoxy group, and (11) a C 6-14  aryl-carbonyl group; and\n R 3  is a C 1-6  alkyl group, or a mono- or di-C 1-6  alkylamino group, or a salt thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 96.0
- Lexical Diversity: 1.39535
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16049359', '15933889', '14779347', '14898633', '14566157']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8196497703769213
- 35 USC 102 Novelty (BERT): 0.5326293908879709
- Combined Prediction Score: 0.7909477324280263
- Mean Citation Score: 359.833626
- Max Citation Score: 364.97223
- Similarity Product: 311.7062010268772

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test