PATENT CLAIM ANALYSIS

Application Number: 15990354
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "464000"]

Abstract:
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D 2  and 25-hydroxyvitamin D 3  and a cellulosic compound. The stabilized formulations exhibit a stable dissolution profile following exposure to storage conditions and demonstrate improved pharmacokinetic parameters compared to unstabilized formulations.

Claim (Index 19):
A stabilized formulation for extended release of a vitamin D compound in the gastrointestinal tract of a subject which ingests the formulation, the formulation comprising a mixture of:\n one or both of 25-hydroxyvitamin D 2  and 25-hydroxyvitamin D 3  in an extended release lipophilic matrix, the lipophilic matrix further comprising a cellulosic stabilizing agent to stabilize the matrix against changes in dissolution release characteristics over time; wherein the formulation, when administered to adult humans having CKD Stage 3 with secondary hyperparathyroidism and vitamin D insufficiency, and at daily oral doses of 60 mcg, is characterized by providing a baseline-adjusted AUC 0-6 wk  of the administered vitamin D compound having a mean of about 1500 ng\u00b7d/mL.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.4
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15990352', '14213285', '15720948', '12109983', '13746982']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7873841472945552
- 35 USC 102 Novelty (BERT): 0.682878630286156
- Combined Prediction Score: 0.7769335955937152
- Mean Citation Score: 531.1571839999998
- Max Citation Score: 663.99115
- Similarity Product: 526.0964844793081

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test