PATENT CLAIM ANALYSIS

Application Number: 15900019
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["435", "006000"]

Abstract:
Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, R 2 , R 2a , R 3 , R 3a , and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

Claim (Index 2):
A method for attenuating or ameliorating one or more symptoms of a cancerous tumor in a mammal in need thereof, the method comprising:\n (a) detecting a cancerous tumor in a mammal that exhibits one or more of overexpression, activation, amplification, and mutation of a Trk kinase; and (b) administering to the mammal a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein:\n ring A is selected from rings A-1 and A-2 having the structures: \n wherein the wavy line labeled 1 indicates the point of attachment of ring A to ring B and the wavy line labeled 2 indicates the point of attachment of ring A to W;\n X is N or CH; \n Y is H or F; \n R 1  is H, (1-3C)alkyl, (1-3C)alkoxy or halogen; \n B is B-1: \n wherein the wavy line labeled 3 indicates the point of attachment to ring A and the wavy line labeled 4 indicates the point of attachment to the pyrazolo[1,5-a]pyrimidine ring of Formula I;\n W is O, NH or CH 2 , wherein when ring A is A-2, then W is CH 2 ; \n m is 0, 1 or 2; \n D is carbon, R 2  and R 2a  are independently H, F, (1-3C)alkyl or OH (provided that R 2  and R 2a  are not both OH), and R 3  and R 3a  are independently H, (1-3C)alkyl or hydroxy(1-3 C)alkyl; \n Z is *\u2014NR 4a C(\u2550O)\u2014, wherein the asterisk indicates the point of attachment of Z to the carbon bearing R 3 ; \n R 4a  is H, (1-6C)alkyl, fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, hydroxy(1-6C alkyl) or dihydroxy(2-6C alkyl); and \n R 5  and R 6  are independently H, halogen, OH, (1-6C)alkyl or hydroxy(1-6C)alkyl.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 88.0
- Lexical Diversity: 1.57143
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14575663', '13698922', '15350888', '15401952', '15401839']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7199734654367298
- 35 USC 102 Novelty (BERT): 0.5713355600314529
- Combined Prediction Score: 0.7051096748962021
- Mean Citation Score: 523.9771599999998
- Max Citation Score: 538.8581
- Similarity Product: 447.7581758809209

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test