PATENT CLAIM ANALYSIS

Application Number: 15866871
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "341000"]

Abstract:
The present invention provides compounds of Formula (I): a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, a solvate thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

Claim (Index 1):
A compound of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, a solvate or a hydrate thereof, wherein:\n ring A is independently a 5- to 6-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR e , O and S; wherein said heteroaryl is substituted with 0-1 R 6  and 0-2 R 7 ; \n R 1  is independently selected from: \u2014(CH 2 ) m \u2014(C 3-6  carbocycle substituted with 0-2 R b  and 0-2 R g ), \u2014(CH 2 ) m -(5- to 6-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR e , O and S; wherein said heteroaryl is substituted with 0-1 R b  and 0-2 R g ), and (a C 1-12  hydrocarbon chain substituted with 0-3 R a ; wherein said hydrocarbon chain may be straight or branched, saturated or unsaturated); \n R 2  is independently selected from: C 1-4  alkyl, C 3-4  cycloalkyl, and C 1-4  haloalkyl; \n R 3  is independently selected from: H, F, C 1-4  alkyl and CN; \n R 4  is independently selected from: H, F, and C 1-4  alkyl; \n R 3  and R 4  may be combined with the carbon atom to which they are attached to form a 3- to 6-membered carbocycle; \n R 6  is independently selected from: halogen, C 1-6  alkyl substituted with 0-2 R h , C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, CO(C 1-4  alkyl), \u2014(CH 2 ) m \u2014C 3-6  carbocycle, \u2014(CH 2 ) m \u2014NR f R i , CN, OR i , SR i , and (a 4- to 6-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR e , O, and S); \n R 7  is independently selected from: halogen, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, and C 1-4  haloalkoxy; \n alternatively, R 6  and R 7 , together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic ring or a 5- to 6-membered heterocyclic ring comprising carbon atoms and 1-3 heteroatoms selected from N, NR e , O, and S; wherein said heterocycle is substituted with 0-2 R g ; \n R a  is, at each occurrence, independently selected from: halogen, OH, C 1-6  alkoxy, C 1-6  haloalkyl, C 1-6  haloalkoxy, N(C 1-4  alkyl) 2 , COOH, and \u2014(CH 2 ) n \u2014R c ; \n R b  is, at each occurrence, independently selected from: halogen, OH, C 1-10  alkyl, C 1-10  alkoxy, C 1-10  haloalkyl, C 1-10  haloalkoxy, C 1-10  alkylthio, C 1-10  haloalkylthio, N(C 1-4  alkyl) 2 , \u2014CONH(C 4-20  alkyl), \u2014CONH(C 4-20  haloalkyl), \u2014O(CH 2 ) s O(C 1-6  alkyl), \u2014O(CH 2 ) s O(C 1-6  haloalkyl), R c , and \u2014(CH 2 ) n \u2014(O) t \u2014(CH 2 ) m R c ; \n R c  is, at each occurrence, independently selected from: C 3-6  cycloalkyl substituted with 0-2 R d , C 3-6  cycloalkenyl substituted with 0-2 R d , \u2014(CH 2 ) m -(phenyl substituted with 0-3 R d ), and (a 5- to 6-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR e , O, and S; wherein said heterocycle is substituted with 0-2 R d ); \n R d  is, at each occurrence, independently selected from: halogen, OH, CN, NO 2 , C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, tetrazolyl, OBn and phenyl; \n R e  is, at each occurrence, independently selected from: H, C 1-8  alkyl, C 1-8  haloalkyl, \u2014(CH 2 ) n \u2014C 3-6  carbocycle, CO(C 1-4  alkyl) and COBn; \n R f  is, at each occurrence, independently selected from: H and C 1-4  alkyl; \n R g  is, at each occurrence, independently selected from: halogen, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, and C 1-4  haloalkoxy; \n R h  is, at each occurrence, independently selected from: OH, halogen, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, and C 1-4  haloalkoxy; \n R 1  is, at each occurrence, independently selected from the group consisting of C 1-4  alkyl, C 3-4  cycloalkyl and phenyl; \n n, at each occurrence, is independently 0 or 1; \n m, at each occurrence, is independently 0, 1, 2, 3, or 4; \n s, at each occurrence, is independently 1, 2, or 3; and \n t, at each occurrence, is independently 0 or 1.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 86.0
- Lexical Diversity: 1.35714
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15123773', '15602515', '15618182', '15123791', '15617079']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7906466136347182
- 35 USC 102 Novelty (BERT): 0.5648147532006608
- Combined Prediction Score: 0.7680634275913125
- Mean Citation Score: 379.091024
- Max Citation Score: 432.3285
- Similarity Product: 429.8565002948642

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test