PATENT CLAIM ANALYSIS

Application Number: 16060109
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "004800"]

Abstract:
The invention provides compositions and methods for inhibiting protein-protein interactions with cap-binding protein 80 (CBP80). In one embodiment, the invention provides compositions comprising linear and macrocylic peptides. In one embodiment, the invention provides methods for treating cancer, heart disease, autoimmune disorders, obesity, diabetes, or chronic inflammation disorders associated with the PGC1 family of co-activators.

Claim (Index 1):
A macrocyclic peptide represented by any one of Formula (I)-Formula (V) wherein X 2  is Met, Leu, Ala, Ile, or Val; X 3  is Asp, Ala, Glu, Asn, Gln, Ser, or Thr; X 4  is Phe or Ala; X 5  is Asp, Glu or Ala; X 6  is Ser, Thr, Ala, Glu, Asp, Gln, Asn, Phe, Tyr, Trp, Met, Leu, Ile, Val, Lys, His, Arg, or Aib; X 7  is Leu, Ile or Ala; X 8  is Leu, Ile or Ala; X 9  is Lys, Ala, Ser, Thr, Glu, Asp, Gln, Asn, Phe, Tyr, Trp, Met, Leu, Ile, Val, His, Arg, Aib, a lysine derivative, a ornithine derivative, or a 2,4-diaminobutyric acid derivative; X 10  is Glu, Gln, Ala, Ser, Thr, Asp, Asn, Phe, Tyr, Trp, Met, Leu, Ile, Val, Lys, His, Arg, or Aib; X 11  is Ala, Gly, Leu, Ile, or Aib; X 12  is Gln, Ala, Asn, Ser, Thr, Glu, Asp, Asn, Phe, Tyr, Trp, Met, Leu, Ile, Val, Lys, His, Arg, or Aib; X 13  is Gln, Arg, Lys, Ala, Ser, Thr, Glu, Asp, Asn, Phe, Tyr, Trp, Met, Leu, Ile, Val, or His; X 14  is Ser, Asn, Ala, Thr, Glu, Asp, Gln, Phe, Tyr, Trp, Met, Leu, Ile, Val, Lys, His, or Arg; R 1  is hydrogen, an acetyl group, or a label molecule, wherein the label molecule is optionally comprises a spacer unit; R 2  is a free carboxylic group or an amide group; R 3  is hydrogen or methyl group; R 4  is hydrogen or methyl group; L 1  is a linker unit, such that the linear dimension between the C\u03b1 carbon atoms connected by the linker unit is between about 10 and 18 Angstrom units; L 2  is \u2014(CH 2 ) 3 CH\u2550CH(CH 2 ) 3 \u2014 or \u2014(CH 2 ) 8 \u2014; and L 3  is \u2014(CH 2 ) 6 CH\u2550CH(CH 2 ) 3 \u2014 or \u2014(CH 2 ) 11 \u2014.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 1.53488
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14398260', '15941030', '14800627', '14118545', '09825517']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8408354194044411
- 35 USC 102 Novelty (BERT): 0.5895685382382048
- Combined Prediction Score: 0.8157087312878174
- Mean Citation Score: 553.978646
- Max Citation Score: 558.4818
- Similarity Product: 392.9003197241664

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test