PATENT CLAIM ANALYSIS

Application Number: 16215183
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-03
Patent Classification: ["514", "021300"]

Abstract:
The present invention is directed to an amphipathic peptide and methods of using the amphipathic peptide for delivering small molecule agents to a cell. Ideally, the amphipathic cell penetrating peptide comprises less than approximately 50 amino acid residues with at least 6 arginine residues, at least 12 Alanine Residues, at least 6 leucine residues, optionally at least one cysteine residue, and at least two but no greater than three glutamic acids wherein the arginine residues are evenly distributed along the length of the peptide; and the peptide has a defined ratio of arginine to negatively charged amino acid residues and a defined ratio of hydrophilic amino acid residues to hydrophobic amino acid residues. The present invention is also directed to a nanoparticle and cell delivery system comprising the amphipathic cell penetrating peptide of the invention. The peptide, nanoparticle or cell delivery system of the invention may be used in therapy. For example, the peptide may be used as a therapeutic agent delivery system, in which the therapeutic agent may include nucleic acids or other small molecules.

Claim (Index 9):
The peptide according to  claim 8  comprising the cell targeting motif sequence conjugated to the peptide via the spacer sequence wherein the cell targeting motif sequence is a metastatic prostate cancer targeting peptide TMTP-1 (NVVRQ) (SEQ ID NO: 12) and the spacer sequence is an alpha helical spacer comprising from 1 to 4 repeats of the sequence EAAAK (SEQ ID NO: 13).

Metadata:
- Claim Count in Document: 44.0
- Percentile: 98.0
- Lexical Diversity: 2.15909
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14649606', '15688484', '14009648', '15160939', '12714106']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7565570733121942
- 35 USC 102 Novelty (BERT): 0.6882512509324844
- Combined Prediction Score: 0.7497264910742233
- Mean Citation Score: 456.45749000000006
- Max Citation Score: 693.7242
- Similarity Product: 682.1860408550978

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test