PATENT CLAIM ANALYSIS

Application Number: 15948359
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "167000"]

Abstract:
Disclosed is a compound of Formula (I) in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, and a are defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are a pharmaceutical composition comprising a compound or salt thereof of Formula (I) and a method of treating a disease which benefits from the modulation of the vitamin D receptor, such as a bone disorder, cardiovascular disease, a cardiovascular complication associated with renal disease, endothelial dysfunction, hyperparathyroidism, hypocalcemia, an immune disorder, left ventricular hypertrophy, a proliferative disease, proteinuria, renal disease, and thrombosis.

Claim (Index 1):
A compound of Formula (I) wherein\n R 1  is \u2550CH 2 ; or \n R 1  and the carbon to which it is bonded together form a cyclopropyl group; \n R 4  and R 5  are the same or different and each is selected from the group consisting of H, C 1-12  alkyl, hydroxyl, C 1-12  alkoxy, and halo; \n wherein said C 1 -C 12  alkyl and said C 1 -C 12  alkoxy are optionally and independently substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aroyl, halo, monohaloalkyl, dihaloalkyl, trihaloalkyl, monohaloalkoxy, dihaloalkoxy, trihaloalkoxy, hydroxy, alkoxy, alkoxycarbonyl, cycloalkyloxy, heterocyclooxy, oxo, alkanoyl, aryl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, alkylheteroaryl, heterocyclyl, aryloxy, alkanoyloxy, amino, monoalkylamino, dialkylamino, trialkylamino, arylamino, arylalkylamino, cycloalkylamino, heterocycloamino, alkanoylamino, aroylamino, aralkanoylamino, mercapto, alkylthio, arylthio, arylalkylthio, cycloalkylthio, heterocyclothio, alkylthiono, arylthiono, arylalkylthiono, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, sulfamato NH 2 SO 2 O\u2014, alkylsulfamato, sulfonamido \u2014SO 2 NH 2 , alkyl sulfonamido, nitro, cyano, carboxy, carbamyl NH 2 CO\u2014, monosubstituted carbamyl selected from alkyl-NH\u2014CO, aryl-NH\u2014CO and arylalkyl-NH\u2014CO and disubstituted carbamyl selected from dialkyl-NCO, diaryl-N\u2014CO and alkyl-aryl-N\u2014CO; \n R 6  is C 1-12  alkyl or aryl; \n wherein said C1-C12 alkyl is optionally and independently substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aroyl, halo, monohaloalkyl, dihaloalkyl, trihaloalkyl, monohaloalkoxy, dihaloalkoxy, trihaloalkoxy, hydroxy, alkoxy, alkoxycarbonyl, cycloalkyloxy, heterocyclooxy, oxo, alkanoyl, aryl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, alkylheteroaryl, heterocyclyl, aryloxy, alkanoyloxy, amino, monoalkylamino, dialkylamino, trialkylamino, arylamino, arylalkylamino, cycloalkylamino, heterocycloamino, alkanoylamino, aroylamino, aralkanoylamino, mercapto, alkylthio, arylthio, arylalkylthio, cycloalkylthio, heterocyclothio, alkylthiono, arylthiono, arylalkylthiono, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, sulfamato NH 2 SO 2 O\u2014, alkylsulfamato, sulfonamido \u2014SO 2 NH 2 , alkyl sulfonamido, nitro, cyano, carboxy, carbamyl NH 2 CO\u2014, monosubstituted carbamyl selected from alkyl-NH\u2014CO, aryl-NH\u2014CO and arylalkyl-NH\u2014CO, and disubstituted carbamyl selected from dialkyl-N\u2014CO, diaryl-N\u2014CO and alkyl-aryl-N\u2014CO; and \n wherein said aryl is optionally independently substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aroyl, halo, monohaloalkyl, dihaloalkyl or trihaloalkyl, monohaloalkoxy, dihaloalkoxy or trihaloalkoxy, hydroxy, alkoxy, alkoxycarbonyl, cycloalkyloxy, heterocyclooxy, oxo, alkanoyl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, alkylheteroaryl, heterocyclyl, aryloxy, alkanoyloxy, amino, monoalkylamino, dialkylamino or trialkylamino, arylamino, arylalkylamino, cycloalkylamino, heterocycloamino, alkanoylamino, aroylamino, aralkanoylamino, mercapto, alkylthio, arylthio, arylalkylthio, cycloalkylthio, heterocyclothio, alkylthiono, arylthiono, arylalkylthiono, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, sulfamato NH 2 SO 2 O\u2014, alkylsulfamato, sulfonamido \u2014SO 2 NH 2 , alkyl sulfonamido, nitro, cyano, carboxy, carbamyl NH 2 CO\u2014, and monosubstituted carbamyl selected from alkyl-NH\u2014CO, aryl-NH\u2014CO and arylalkyl-NHCO, and disubstituted carbamyl selected from dialkyl-N\u2014CO, diaryl-N\u2014CO and alkylaryl-N\u2014CO; \n X is oxygen or sulfur; and \n a is 0-5; \n provided that when a is 1-5, then R 6  is optionally substituted aryl, the optional substituents of aryl being as defined above; \n and when a is 0, R is optionally substituted C 1-12  alkyl, the optional substituents of C 1-12  alkyl being as defined above; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 91.0
- Lexical Diversity: 1.86364
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13521980', '15537292', '13404958', '13102705', '11404267']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7737876664107212
- 35 USC 102 Novelty (BERT): 0.5024673812647101
- Combined Prediction Score: 0.74665563789612
- Mean Citation Score: 257.772788
- Max Citation Score: 264.4791
- Similarity Product: 215.52729252070785

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test