PATENT CLAIM ANALYSIS

Application Number: 16022031
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-02
Patent Classification: ["514", "234500"]

Abstract:
The present invention provides aza-heteroaryl derivatives of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A, W, R 4 , R 5 , and R 6  are defined herein, that inhibit the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Claim (Index 19):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein: A is O, S, or CH\u2550CH; R 1  is H, methyl, ethyl, cyclopropyl, phenyl, or a tetrahydrofuran ring; R 2  is H, methyl, propyl, or phenyl; or R 1  and R 2 , together with the carbon atoms to which they are attached, form a phenyl ring or cyclohexene ring, which is optionally substituted by 1 or 2 independently selected R 11  groups. R 3  is H; R 4 , R 5 , and R 6  are each H; W is Br or Cy; Cy is a phenyl ring, a piperazine ring, a pyridine ring, a pyrimidine ring, an imidazole ring, an indazole ring, or a 1H-pyrazolo[4,3-b]pyridine ring, each of which is optionally substituted by 1 or 2 substituents independently selected from halo, C 1-6  alkyl, C 1-6  haloalkyl, Cy 1 , \u2014(C 1-2  alkylene)-Cy 1 , CN, OR a , P(O)R a R b , NR c R d , NR c C(O)R b , NR c C(O)NR c R d , NR c S(O) 2 R b , NR c S(O) 2 NR c R d , S(O) 2 R b , and S(O) 2 NR c R d ; each R 11  is independently selected from halo, C 1-6  alkyl, and C 1-6  haloalkyl; each R a  is independently selected from H and C 1-6  alkyl; wherein said C 1-6  alkyl is optionally substituted with 1, 2, 3, or 4 independently selected R g  groups; each R c  and R d  is independently selected from H, C 1-6  alkyl, and Cy 1 ; wherein said C 1-6  alkyl is optionally substituted with 1, 2, 3, or 4 independently selected R g  groups; each R b  is independently selected from C 1-6  alkyl and Cy 1 ; wherein said C 1-6  alkyl is optionally substituted with 1, 2, 3, or 4 independently selected R g  groups; each Cy 1  is independently selected from phenyl and 6-membered heterocycloalkyl, each optionally substituted by 1 or 2 independently selected R g  groups; and each R g  is, independently, OH, C 1-6  alkyl, C 1-4  haloalkyl, halo, or carboxy.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 94.0
- Lexical Diversity: 1.55769
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15019144', '13854789', '12972155', '15631417', '15065409']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7983059038999846
- 35 USC 102 Novelty (BERT): 0.5742431640862143
- Combined Prediction Score: 0.7758996299186076
- Mean Citation Score: 379.18514
- Max Citation Score: 453.30923
- Similarity Product: 445.29872650849165

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test