PATENT CLAIM ANALYSIS

Application Number: 15760874
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-03
Patent Classification: ["514", "04400A"]

Abstract:
A method for preparing exosomes or exosome-like vesicles packaged with a nucleic acid of interest is provided. In certain embodiments, the method may comprise: introducing into an exosome-producing cell a nucleic acid construct comprising the nucleic acid sequence of interest incorporated in a pre-miR-451 structural mimic, and allowing the cell to produce exosomes. Nucleic acid constructs, compositions, and uses thereof are also provided.

Claim (Index 15):
A method for identifying whether a candidate exosome-producing cell is an exosome-producing cell which is suitable for producing enriched exosomes or exosome-like vesicles using a nucleic acid construct comprising a gene silencing nucleic acid, nucleic acid of interest, or a precursor thereof, incorporated within a pre-miR-451 structural mimic, said method comprising:\n quantitating miR-451 content of exosomes produced by said candidate exosome-producing cell and determining whether miR-451 is exosomally enriched; wherein exosomal enrichment of miR-451 indicates that the candidate exosome-producing cell is suitable for producing the enriched exosomes or exosome-like vesicles.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.42
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13252784', '15451016', '14630419', '13642802', '12149725']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8090608279923845
- 35 USC 102 Novelty (BERT): 0.5466795688452805
- Combined Prediction Score: 0.7828227020776742
- Mean Citation Score: 393.004388
- Max Citation Score: 431.80292
- Similarity Product: 283.0753031629467

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test