PATENT CLAIM ANALYSIS

Application Number: 16094826
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["514", "237200"]

Abstract:
The present invention relates to a novel N-acylurea derivative and the use thereof for the prevention or treatment of cardiovascular disease, and more particularly to a novel N-acylurea derivative, a pharmaceutical composition for prevention or treatment of cardiovascular disease, which contains the N-acylurea derivative as an active ingredient, and a method of preparing the N-acylurea derivative. The N-acylurea derivative according to the present invention can inhibit platelet aggregation by inhibiting the activity of talin in the intracellular matrix, and thus can be useful for the prevention or treatment of cardiovascular disease.

Claim (Index 9):
A method of preparing a compound of Formula 1 below, comprising:\n (a) obtaining 2-chloroacetyl isocyanate by mixing 2-chloroacetamide and oxalyl chloride in a reactor, adding dichloroethane and heating and stirring, followed by concentrating; (b) obtaining carbamoyl 2-chloroacetamide by adding methylene chloride to the obtained 2-chloroacetyl isocyanate, and then adding a nucleophilic reagent and reacting, followed by concentrating; and (c) obtaining N-acylurea derivative by adding methanol to the obtained carbamoyl 2-chloroacetamide, adding and reacting a nucleophilic reagent while stirring, extracting an N-acylurea derivative using an organic solvent, wherein R 1  is hydrogen, halogen, hydroxy, C 1-6  alkyl, C 1-6  haloaklyl, C 6-12  aryl, C 5-12  heteroaryl, C 4-9  heterocyclyl, heteroatom-linked C 1-6  alkyl, or a heteroatom-linked C 6-12  aryl, C 1-12  heteroaryl or C 1-12  heterocyclyl, and the aryl, heteroaryl or heterocyclyl can be unsubstituted or substituted, and the heteroatom is selected from N, O and S; R 2  is hydrogen, C 1-6  alkyl, C 1-6  haloalkyl, C 6-12  aryl, C 5-12  heteroaryl, C 4-9  heterocyclyl, C 2-6  alkylene-C 6-12  aryl, C 2-6  alkylene-C 1-12  heteroaryl, or C 2-6  alkylene-C 1-12  heterocyclyl, wherein the aryl, heteroaryl or heterocyclyl may be unsubstituted or substituted, and the heteroatom is selected from N, O and S; and R 3  and R 4  are each independently hydrogen, C 1-6  alkyl or C 1-6  haloalkyl.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 97.0
- Lexical Diversity: 2.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11735751', '11937159', '13003558', '15311817', '14112735']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7709025879102317
- 35 USC 102 Novelty (BERT): 0.5033290143962358
- Combined Prediction Score: 0.7441452305588321
- Mean Citation Score: 264.835466
- Max Citation Score: 268.83524
- Similarity Product: 198.9657372926378

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test