PATENT CLAIM ANALYSIS

Application Number: 15780896
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["562", "503000"]

Abstract:
The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silicagel chromatography and the salt formation is carried out by using solid tromethamine base.

Claim (Index 1):
Process for the preparation of Carboprost of formula I and\n its tromethamine salt of formula Ia \n by selective alkylation of the enone of the general formula II, where R stands for hydrogen atom or protecting group, by reduction of the resulting enol of the general formula III where the meaning of R is as defined above, by removal of the R protecting group of the resulting lactol of the general formula IV, by reacting the lactol epimers of formula V in Wittig reaction to obtain the Carboprost epimers of formula VI, by transforming the Carboprost epimers into their methyl ester, by chromatographic separation of the methyl ester epimers of formula VII by hydrolysis of the epimer of formula VIII and if desired by formation of the tromethamine salt, comprising that\n the selective alkylation is carried out in the presence of chiral auxiliary, in aprotic organic solvent, with Grignard reagent, \n chromatography is carried out by gravity silica gel chromatography, \n the tromethamine salt is formed by using solid tromethamine base.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 94.0
- Lexical Diversity: 1.4898
- Patent Class: 562.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16091019', '13500254', '11874218', '15518096', '14123497']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6936144610165959
- 35 USC 102 Novelty (BERT): 0.502968774398055
- Combined Prediction Score: 0.6745498923547417
- Mean Citation Score: 207.557276
- Max Citation Score: 228.55806
- Similarity Product: 154.48631220248222

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test