PATENT CLAIM ANALYSIS

Application Number: 15758709
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["544", "171000"]

Abstract:
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

Claim (Index 117):
A compound selected from the group consisting of:\n (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)pivalamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)butyramido)phenyl)acrylate; (E)-Methyl 3-(3-(((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)(ethoxycarbonyl)amino)phenyl)acrylate; (E)-Methyl 3-(3-(4-cyano-N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)benzamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)tetrahydro-2H-pyran-4-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)oxetane-3-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)phenyl)acrylate; (E)-Methyl 3-(3-((1r,4r)-N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-methoxycyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-((1s,4s)-N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-methoxycyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-methoxybenzamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cycloheptanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(-N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)adamantane-1-carboxamido)phenyl)acrylate; (E)-methyl 3-(3-(N-(4-cyclohexylbenzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-3,4-difluorobenzamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-fluorobenzamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-1-methylcyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-fluorophenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)bicyclo[2.2.1]heptane-2-carboxamido)-5-fluorophenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-methyltetrahydro-2H-pyran-4-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-2-methoxybenzamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-1,1-dioxidotetrahydro-2H-thiopyran-4-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)tetrahydro-2H-thiopyran-4-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-3-methoxybenzamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-1-(methylsulfonyl)azetidine-3-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-(2-morpholinoethoxy)benzamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-(methylthio)cyclohexanecarboxamido)phenyl)acrylate; cis-(E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-(methylsulfonyl)cyclohexanecarboxamido)phenyl)acrylate; trans-(E)-methyl 3 -(3 -(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-(methylsulfonyl)cyclohexanecarboxamido)phenyl)acrylate; trans-4-(((4\u2032-(Dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)(3-((E)-3-methoxy-3-oxoprop-1-en-1-yl)phenyl)carbamoyl)cyclohexanecarboxylic acid; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-6-oxopiperidine-3-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-2-oxopiperidine-4-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-1-oxidotetrahydro-2H-thiopyran-4-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-(methylsulfinyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-hydroxybenzamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-(2-hydroxyethoxy)benzamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-3-hydroxy-2,2-dimethylpropanamido)phenyl)acrylate; (E)-Methyl 3-(3-(3-chloro-N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-2,2-dimethylpropanamido)phenyl)acrylate; trans-(E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-2-hydroxycyclohexanecarboxamido)phenyl)acrylate; cis-(E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-2-hydroxycyclohexanecarboxamido)phenyl)acrylate; cis-(E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-3-hydroxycyclohexanecarboxamido)phenyl)acrylate; trans-(E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-3-hydroxycyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclopentanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclobutanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)amino)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-oxocyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)tetrahydro-2H-pyran-2-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-1,4-dioxane-2-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)tetrahydro-2H-pyran-3-carboxamido)phenyl)acrylate; cis-(E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-hydroxycyclohexanecarboxamido)phenyl)acrylate; trans-(E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-hydroxycyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((2\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(pyridin-4-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-cyano-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-cyano-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-fluoro-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-fluoro-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((2\u2032-fluoro-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(1-methyl-1H-pyrazol-4-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(pyridin-3-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-(trifluoromethoxy)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(3,5-dimethylisoxazol-4-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-isopropoxy-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((2\u2032-fluoro-4\u2032-methoxy-[1,1\u2032-biphenyl]-4-y1)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-chloro-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-(trifluoromethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(trifluoromethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(6-(dimethylamino)pyridin-3-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-methylphenyl)acrylate; (E)-Methyl 3-(5-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-methylphenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-methylphenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-4-methylphenyl)acrylate; Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)propanoate; (E)-N-((4\u2032-(Dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-N-(3-(3-methoxyprop-1-en-1-yl)phenyl)cyclohexanecarboxamide; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)but-2-enoate; (E)-Methyl 3-(3-(N-(1-(4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)ethyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-isopropyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(pyrrolidin-1-yl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(1H-indazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-methyl 3-(3-(N-((4\u2032-(dimethylamino)-2-fluoro-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-methyl 3-(3-(N-((4\u2032-(dimethylamino)-3-fluoro-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-2-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-3-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-hydroxy-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((2\u2032-hydroxy-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-hydroxy-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-methoxy-4\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((2\u2032,6\u2032-difluoro-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-((tert-butoxycarbonyl)(methyl)amino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(methylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(1-methyl-1H-indol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)isonicotinamido)phenyl)acrylate; (E)-Methyl 4\u2032-((N-(3-(3-methoxy-3-oxoprop-1-en-1-yl)phenyl)cyclohexanecarboxamido)methyl)-[1,1\u2032-biphenyl]-3-carboxylate; (E)-Methyl 4\u2032-((N-(3-(3-methoxy-3-oxoprop-1-en-1-yl)phenyl)cyclohexanecarboxamido)methyl)-[1,1\u2032-biphenyl]-4-carboxylate; (E)-Methyl 3-(3-(N-((4\u2032-(methylsulfonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-tert-Butyl 4-(((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)(3-(3-methoxy-3-oxoprop-1-en-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate; (E)-Methyl 3-(3-(N-((3\u2032-(hydroxymethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(hydroxymethyl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-(methylsulfonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzo[d][1,3]dioxol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-chloro-4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((2-cyano-4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3-cyano-4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-2-ethyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-3-ethyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)piperidine-4-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(1-acetyl-N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)piperidine-4-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-methoxy-3\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methyl)-1-(methylsulfonyl)piperidine-4-carboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)-2-methylacrylate; (E)-Methyl 3-(3-(N-((3\u2032-cyano-4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(pyridin-2-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((2\u2032-cyano-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(thiazol-2-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(thiazol-4-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(thiazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-isopropyl-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(prop-1-en-2-yl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-cyano-4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-3\u2032-fluoro-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-methyl 3-(3-(N-((4\u2032-(dimethylamino)-3\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(azetidin-1-yl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(2-(dimethylamino)pyrimidin-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(5-(dimethylamino)pyrazin-2-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(6-(dimethylamino)pyridazin-3-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(N-methylmethylsulfonamido)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-fluoro-4\u2032-(methylsulfonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((2\u2032-fluoro-4\u2032-(methylsulfonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzo[d]thiazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((3\u2032-chloro-4\u2032-(methylsulfonyl)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzo[d]oxazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzo[d]oxazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzo[d]isoxazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzo[d]thiazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzo[d]isoxazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzo[d]isothiazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzo[d]isothiazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(3-fluoro-1-methyl-1H-indazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(3-methylbenzo[d]isothiazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(4-methylpiperazin-1-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-morpholinobenzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(piperidin-1-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(piperazin-1-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(naphthalen-1-ylmethyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-([1,1\u2032-biphenyl]-2-ylmethyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-([1,1\u2032-biphenyl]-3-ylmethyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-iso-Propyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Ethyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-ethylphenyl)acrylate; (E)-2-Hydroxyethyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Cyclohexyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Isobutyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-2-Methoxyethyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-2-(Dimethylamino)ethyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-(Tetrahydrofuran-2-yl)methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-2,2,2-Trifluoroethyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Benzyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-methoxyphenyl)acrylate; (E)-Methyl 3-(3-cyano-5-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-chloro-5-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-(trifluoromethyl)phenyl)acrylate; Methyl 3-(3-(N-((4\u2032-(Dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)propiolate; (E)-3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylic acid; (E)-3-(3-((1s,4s)-N-((4\u2032-(Dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-hydroxycyclohexanecarboxamido)phenyl)acrylic acid; Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-methylphenyl)propanoate; Methyl 3-(5-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-methylphenyl)propanoate; Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-methylphenyl)propanoate; Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-4-methylphenyl)propanoate; Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)butanoate; Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)-2-methylpropanoate; (E)-Methyl 3-(3-(trans-4-((tert-butoxycarbonyl)amino)-N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(trans-4-amino-N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3 -(trans-N 4(4\u2032 -(di methylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4- ((methoxycarbonyl)amino)cyclohexanecarboxamido)phenyl)acrylate; trans-(E)-Methyl 3-(3-(4-acetamido-N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate; trans-(E)-Methyl 3-(3-(N-((4\u2032-(dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-4-(methylsulfonamido)cyclohexanecarboxamido)phenyl)acrylate; N-((4\u2032-(Dimethylamino)-[1,1\u2032-biphenyl]-4-yl)methyl)-N-(3-(3-methylbut-2-en-1-yl)phenyl)cyclohexanecarboxamide; (E)-Methyl 3-(3-(N-(4-benzamidobenzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(N-methylbenzamido)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzylamino)benzyl)cyclohexanecarboxamido)phenyl)acrylate; (E)-Methyl 3-(3-(N-(4-(benzyl(methyl)amino)benzyl)cyclohexanecarboxamido)phenyl)acrylate; or a pharmaceutically acceptable salt, or solvate thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 90.0
- Lexical Diversity: 1.54839
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15758712', '15695911', '15023465', '13388502', '13821190']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8009143595400607
- 35 USC 102 Novelty (BERT): 0.574085636239081
- Combined Prediction Score: 0.7782314872099628
- Mean Citation Score: 361.407644
- Max Citation Score: 488.3862
- Similarity Product: 379.8781216877461

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test