PATENT CLAIM ANALYSIS

Application Number: 15902690
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-11
Patent Classification: ["514", "023000"]

Abstract:
Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Claim (Index 1):
A method of treating a Filoviridae infection in a human in need thereof comprising administering a therapeutically effective amount of a compound of Formula IV: or a pharmaceutically acceptable salt, hydrate or ester, thereof; wherein, R 7  is selected from the group consisting of\n a) H, \u2014C(\u2550O)R 11 , \u2014C(\u2550O)OR 11 , \u2014C(\u2550O)NR 11 R 12 , \u2014C(\u2550O)SR 11 , \u2014S(O)R 11 , \u2014S(O) 2 R 11 , \u2014S(O)(OR 11 ), \u2014S(O) 2 (OR 11 ), or \u2014SO 2 NR 11 R 12 ; \n b) \n c) a group selected from: wherein:\n R c  is selected from the group of phenyl, 1-naphthyl, 2-naphthyl, \n R d  is selected from the group of H or CH 3 ; R e1  and R e2  are each independently selected from the group of H, (C 1 -C 6 )alkyl or benzyl; R f  is selected from the group of from H, (C 1 -C 8 )alkyl, benzyl, (C 3 -C 6 )cycloalkyl, and \u2014CH 2 \u2014(C 3 -C 6 )cycloalkyl; R g  is selected from selected from the group of (C 1 -C 8 )alkyl, \u2014O\u2014(C 1 -C 8 )alkyl, benzyl, \u2014O-benzyl, \u2014CH 2 \u2014(C 3 -C 6 )cycloalkyl, \u2014O\u2014CH 2 \u2014(C 3 -C 6 )cycloalkyl, and CF 3 ; and n\u2032 is an integer selected from the group of 1, 2, 3, and 4; wherein each R 11  or R 12  is independently H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 4 -C 8 )carbocyclylalkyl, (C 6 -C 20 ) optionally substituted aryl, optionally substituted heteroaryl, \u2014C(\u2550O)(C 1 -C 8 )alkyl, \u2014S(O) n (C 1 -C 8 )alkyl or (C 6 -C 20 )aryl(C 1 \u2014C)alkyl; or R 11  and R 12  taken together with a nitrogen to which they are both attached form a 3 to 7 membered heterocyclic ring wherein any one carbon atom of said heterocyclic ring can optionally be replaced with \u2014O\u2014, \u2014S\u2014 or \u2014NR a \u2014; each R a  is independently selected from the group of H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 6 -C 20 )aryl(C1-C)alkyl, (C 4 -C 8 )carbocyclylalkyl, \u2014C(\u2550O)R, \u2014C(\u2550O)OR, \u2014C(\u2550O)NR 2 , \u2014C(\u2550O)SR, \u2014S(O)R, \u2014S(O) 2 R, \u2014S(O)(OR), \u2014S(O) 2 (OR), or \u2014SO 2 NR 2 ; wherein each R is independently selected from the group of H, (C 1 -C 8 ) alkyl, (C 1 -C 8 ) substituted alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 ) substituted alkenyl, (C 2 -C 8 ) alkynyl, (C 2 -C 8 ) substituted alkynyl, (C 6 -C 20 )aryl, (C 6 -C 20 ) substituted aryl, (C 2 -C 20 )heterocyclyl, (C 2 -C 20 ) substituted heterocyclyl, (C 6 -C 20 )aryl(C 1 -C 8 )alkyl or substituted (C 6 -C 20 )aryl(C 1 -C 8 )alkyl; each n is an integer independently selected from the group of 0, 1, or 2; and wherein each (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl or (C 6 -C 20 )aryl(C 1 -C 8 )alkyl of each R 11  or R 12  is, independently, optionally substituted with one or more substituents selected from the group of halo, hydroxy, CN, N 3 , N(R a ) 2  or OR a ; and wherein one or more of the non-terminal carbon atoms of each said (C 1 -C 8 )alkyl may be optionally replaced with \u2014O\u2014, \u2014S\u2014 or \u2014NR a \u2014.

Metadata:
- Claim Count in Document: 58.0
- Percentile: 88.0
- Lexical Diversity: 1.55882
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15246240', '14926062', '15267433', '12013640', '14830121']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7081203371440543
- 35 USC 102 Novelty (BERT): 0.6061336233587536
- Combined Prediction Score: 0.6979216657655243
- Mean Citation Score: 334.652744
- Max Citation Score: 450.78598
- Similarity Product: 439.3201442607832

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test