PATENT CLAIM ANALYSIS

Application Number: 15949156
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["424", "142100"]

Abstract:
The disclosure relates to novel uses and regimens for accelerating/improving physical recovery in a patient with disuse atrophy triggered by reduced mobility due to a hip fracture and consequent major surgery, which employ a therapeutically effective amount of a myostatin antagonist, e.g., a myostatin binding molecule, e.g., a myostatin antibody or an ActRII receptor binding molecule, an ActRII receptor antibody, such as the bimagrumab antibody.

Claim (Index 2):
A method of treating a patient having disuse atrophy triggered by reduced mobility due to a hip fracture and consequent major surgery for hip fracture repair, comprising administering a therapeutically effective amount of an antibody or antigen binding fragment thereof that binds to human ActRIIB to a patient in need thereof, wherein said antibody or antigen binding fragment thereof comprises:\n i) an immunoglobulin V H  domain comprising the amino acid sequence set forth as SEQ ID NO:107 and an immunoglobulin V L  domain comprising the amino acid sequence set forth as SEQ ID NO:93; ii) an immunoglobulin V H  domain comprising, in sequence, a complementarity determining region (CDR) 1 comprising the amino acid sequence set forth as SEQ ID NO:9, a CDR2 comprising the amino acid sequence set forth as SEQ ID NO:23, and a CDR3 comprising the amino acid sequence set forth as SEQ ID NO:37, and an immunoglobulin V L  domain comprising, in sequence, a CDR1 comprising the amino acid sequence set forth as SEQ ID NO:51, a CDR2 comprising the amino acid sequence set forth as SEQ ID NO:65 and a CDR3 comprising the amino acid sequence set forth as SEQ ID NO:79.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 91.0
- Lexical Diversity: 1.46
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15304010', '15456392', '12767509', '15637867', '14447444']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7257692567709205
- 35 USC 102 Novelty (BERT): 0.5572622964424319
- Combined Prediction Score: 0.7089185607380717
- Mean Citation Score: 386.55955200000005
- Max Citation Score: 430.37146
- Similarity Product: 323.2476956475103

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test