PATENT CLAIM ANALYSIS

Application Number: 15756908
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "006100"]

Abstract:
The invention relates to the use of certain micro-RNAs circulating in the blood serum or blood plasma in the form of diagnostic profiles as a marker in an in vitro method for distinguishing between patients for which a myocardial biopsy is necessary for the diagnostic identification of a heart muscle disease and patients for which myocardial biopsy is not necessary, and for the optional differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases affecting the heart.

Claim (Index 8):
The in-vitro or in-vivo method as claimed in  claim 1 , wherein:\n the diagnostic profile for identifying erythrovirus-induced cardiomyopathy additionally comprises at least 3 microRNAs or synthetic nucleic acids having identical or complementary sequences, selected from the group consisting of the following microRNAs:\n hsa-miR-103b (SEQ ID NO: 117), hsa-miR-125a-5p (SEQ ID NO: 118), hsa-miR-1271-5p (SEQ ID NO: 119), hsa-miR-1274B (SEQ ID NO: 120), hsa-miR-138-1-3p (SEQ ID NO: 121), hsa-miR-146b-3p (SEQ ID NO: 122), hsa-miR-190a-5p (SEQ ID NO: 123), hsa-miR-199a-5p (SEQ ID NO: 124), hsa-miR-26b-3p (SEQ ID NO: 125), hsa-miR-320c (SEQ ID NO: 126), hsa-miR-3617-5p (SEQ ID NO: 127), hsa-miR-362-5p (SEQ ID NO: 128), hsa-miR-3663-3p (SEQ ID NO: 129), hsa-miR-367-3p (SEQ ID NO: 130), hsa-miR-3922-5p (SEQ ID NO: 131), hsa-miR-424-5p (SEQ ID NO: 132), hsa-miR-432-5p (SEQ ID NO: 133), hsa-miR-4429 (SEQ ID NO: 134), hsa-miR-4698 (SEQ ID NO: 135), hsa-miR-4726-3p (SEQ ID NO: 136), hsa-miR-4743-5p (SEQ ID NO: 137), hsa-miR-497-5p (SEQ ID NO: 138), hsa-miR-502-3p (SEQ ID NO: 139), hsa-miR-520d-3p (SEQ ID NO: 140), hsa-miR-520f-3p (SEQ ID NO: 141), hsa-miR-597-5p (SEQ ID NO: 142), hsa-miR-625-3p (SEQ ID NO: 143), hsa-miR-628-5p (SEQ ID NO: 144), hsa-miR-629-5p (SEQ ID NO: 145), hsa-miR-758-3p (SEQ ID NO: 146), mmu-miR-374-5p (SEQ ID NO: 147).

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.56
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13899555', '14788843', '15320208', '13642321', '15237364']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6975749398386369
- 35 USC 102 Novelty (BERT): 0.5224961747839988
- Combined Prediction Score: 0.6800670633331731
- Mean Citation Score: 338.831186
- Max Citation Score: 342.94568
- Similarity Product: 224.58899842395303

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test