PATENT CLAIM ANALYSIS

Application Number: 15864750
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "253100"]

Abstract:
The invention relates to compounds of formula IA and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula IA or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formula IA or a pharmaceutically acceptable derivative thereof.

Claim (Index 3):
A compound of formula II: or a pharmaceutically acceptable salt, solvate, stereoisomer, geometric isomer or tautomer thereof, wherein\n X is O, S, N\u2014CN, N\u2014OH, or N\u2014OR 10 ; \n W is N or C; \n the dashed line denotes the presence or absence of a bond, and when the dashed line denotes the presence of a bond or W is N then R 4  is absent, otherwise R 4  is \u2014H, \u2014OH, \u2014OCF 3 , -halo, \u2014(C 1 -C 6 )alkyl, \u2014CH 2 OH, \u2014CH 2 Cl, \u2014CH 2 Br, \u2014CH 2 I, \u2014CH 2 F, \u2014CH(halo) 2 , \u2014CF 3 , \u2014OR 10 , \u2014SR 10 , \u2014COOH, \u2014COOR 10 , \u2014C(O)R 10 , \u2014C(O)H, \u2014OC(O)R 10 , \u2014OC(O)NHR 10 , \u2014NHC(O)R 13 , \u2014CON(R 13 ) 2 , \u2014S(O) 2 R 10 , or \u2014NO 2 ; \n R 10  is \u2014(C 1 -C 4 )alkyl; \n each R 13  is independently \u2014H, \u2014(C 1 -C 4 )alkyl, \u2014(C 1 -C 4 )alkenyl, \u2014(C 1 -C 4 )alkynyl, or -phenyl; \n Ar 1  is \n Ar 2  is c is the integer 0, 1, or 2; Y 1 , Y 2 , and Y 3  are independently C or N; wherein for each Y 1 , Y 2 , and Y 3  that is N, the N is bonded to one R 20  group, and for each Y 1 , Y 2 , and Y 3  that is C, the C is bonded to two R 20  groups, provided that there are no more than a total of two (C 1 -C 6 )alkyl groups substituted on all of Y 1 , Y 2 , and Y 3 ; R 12a  and R 12b  are independently \u2014H or \u2014(C 1 -C 6 )alkyl; E is \u2550O, \u2550S, \u2550CH(C 1 -C 5 )alkyl, \u2550CH(C 1 -C 5 )alkenyl, \u2014NH(C 1 -C 6 )alkyl, or \u2550N\u2014OR 20 ; R 1  is \u2014H, -halo, \u2014(C 1 -C 4 )alkyl, \u2014NO 2 , \u2014CN, \u2014OH, \u2014OCH 3 , \u2014NH 2 , \u2014C(halo) 3 , \u2014CH(halo) 2 , \u2014CH 2 (halo), \u2014OC(halo) 3 , \u2014OCH(halo) 2 , or \u2014OCH 2 (halo); each R 2  is independently: (a) -halo, \u2014OH, \u2014O(C 1 -C 4 )alkyl, \u2014CN, \u2014NO 2 , \u2014NH 2 , \u2014(C 1 -C 10 )alkyl, \u2014(C 2 -C 10 )alkenyl, \u2014(C 2 -C 10 )alkynyl, or -phenyl, or (b) a group of formula Q; wherein Q is Z 1  is \u2014OH, \u2014SH, \u2014N(R 20 ) 2 , \u2014CH 2 \u2014OH, \u2014CH 2 \u2014SH, or \u2014CH 2 \u2014N(R 20 ) 2 ; Z 2  is \u2014H, \u2014CH 3 , or \u2014CH 2 OR 7  and each Z 3  is independently \u2014H or \u2014CH 3 ; J is \u2014OH, \u2014SH, or \u2014N(R 20 ) 2 ; provided that at least one R 2  group is a group of formula Q; each R 3  is independently: (a) \u2014H or \u2014(C 1 -C 6 )alkyl; or (b) two R 3  groups together form a (C 2 -C 6 )bridge, which is unsubstituted or substituted with 1, 2 or 3 independently selected R 8  groups, and which bridge optionally contains \u2014HC\u2550CH\u2014 within the (C 2 -C 6 )bridge; or (c) two R 3  groups together form a \u2014CH 2 \u2014N(R a )\u2014CH 2 \u2014 bridge, a bridge, or a bridge;\n R a  is \u2014H, \u2014(C 1 -C 6 )alkyl, \u2014(C 3 -C 8 )cycloalkyl, \u2014CH 2 \u2014C(O)\u2014R c , \u2014(CH 2 )\u2014C(O)\u2014OR c , \u2014(CH 2 )\u2014C(O)\u2014N(R c ) 2 , \u2014(CH 2 ) 2 \u2014O\u2014R c , \u2014(CH 2 ) 2 \u2014S(O) 2 \u2014N(R c ) 2 , or \u2014(CH 2 ) 2 \u2014N(R c )S(O) 2 \u2014R c ; \n R b  is: \n (a) \u2014H, \u2014(C 1 -C 6 )alkyl, \u2014(C 3 -C 8 )cycloalkyl, -(3- to 7-membered)heterocycle, \u2014N(R c ) 2 , \u2014N(R c )\u2014(C 3 -C 8 )cycloalkyl, or \u2014N(R c )-(3- to 7-membered)heterocycle; or \n (b) -phenyl, -(5- or 6-membered)heteroaryl, \u2014N(R c )-phenyl, or \u2014N(R c )-(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with 1, 2 or 3 independently selected R 7  groups; \n each R c  is independently \u2014H or \u2014(C 1 -C 4 )alkyl; \n each R 7  is independently \u2014H, \u2014(C 1 -C 6 )alkyl, \u2014(C 2 -C 6 )alkenyl, \u2014(C 2 -C 6 )alkynyl, \u2014(C 3 -C 8 )cycloalkyl, \u2014(C 5 -C 8 )cycloalkenyl, -phenyl, \u2014(C 1 -C 6 )haloalkyl, \u2014(C 1 -C 6 )hydroxyalkyl, \u2014(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, \u2014(C 1 -C 6 )alkyl-N(R 20 ) 2 , or \u2014CON(R 20 ) 2 ; \n each R 8  and R 9  is independently: \n (a) \u2014(C 1 -C 6 )alkyl, \u2014(C 2 -C 6 )alkenyl, \u2014(C 2 -C 6 )alkynyl, \u2014(C 3 -C 8 )cycloalkyl, \u2014(C 5 -C 8 )cycloalkenyl, or -phenyl, each of which is unsubstituted or substituted with 1 or 2 \u2014OH groups; or \n (b) \u2014H, \u2014CH 2 C(halo) 3 , \u2014C(halo) 3 , \u2014CH(halo) 2 , \u2014CH 2 (halo), \u2014OC(halo) 3 , \u2014OCH(halo) 2 , \u2014OCH 2 (halo), \u2014SC(halo) 3 , \u2014SCH(halo) 2 , \u2014SCH 2 (halo), \u2014CN, \u2014O\u2014CN, \u2014OH, -halo, \u2014N 3 , \u2014NO 2 , \u2014CH\u2550NR 7 , \u2014N(R 7 ) 2 , \u2014NR 7 OH, \u2014OR 7 , \u2014C(O)R 7 , \u2014C(O)OR 7 , \u2014OC(O)R 7 , \u2014OC(O)OR 7 , \u2014SR 7 , \u2014S(O)R 7 , or \u2014S(O) 2 R 7 ; \n each R 11  is independently \u2014CN, \u2014OH, \u2014(C 1 -C 6 )alkyl, \u2014(C 2 -C 6 )alkenyl, -halo, \u2014N 3 , \u2014NO 2 , \u2014N(R 7 ) 2 , \u2014CH\u2550NR 7 , \u2014NR 7 OH, \u2014OR 7 , \u2014C(O)R 7 , \u2014C(O)OR 7 , \u2014OC(O)R 7 , or \u2014OC(O)OR 7 ; \n each R 14  is independently \u2014H, \u2014(C 1 -C 6 )alkyl, \u2014(C 2 -C 6 )alkenyl, \u2014(C 2 -C 6 )alkynyl, \u2014(C 3 -C 8 )cycloalkyl, \u2014(C 5 -C 8 )cycloalkenyl, \u2014(C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, -phenyl, \u2014C(halo) 3 , \u2014CH(halo) 2 , \u2014CH 2 (halo), -(3- to 7-membered)heterocycle, \u2014(C 1 -C 6 )haloalkyl, \u2014(C 2 -C 6 )haloalkenyl, \u2014(C 2 -C 6 )haloalkynyl, \u2014(C 2 -C 6 )hydroxyalkenyl, \u2014(C 2 -C 6 )hydroxyalkynyl, \u2014(C 1 -C 6 )alkoxy(C 2 -C 6 )alkyl, \u2014(C 1 -C 6 )alkoxy(C 2 -C 6 )alkenyl, \u2014(C 1 -C 6 )alkoxy(C 2 -C 6 )alkynyl, \u2014(C 1 -C 6 )alkoxy(C 3 -C 8 )cycloalkyl, \u2014CN, \u2014OH, -halo, \u2014OC(halo) 3 , \u2014N 3 , \u2014NO 2 , \u2014CH\u2550NR 7 , \u2014N(R 7 ) 2 , \u2014NR 7 OH, \u2014OR 7 , \u2014SR 7 , \u2014O(CH 2 ) b OR 7 , \u2014O(CH 2 ) b SR 7 , \u2014O(CH 2 ) b N(R 7 ) 2 , \u2014N(R 7 )(CH 2 ) b OR 7 , \u2014N(R 7 )(CH 2 ) b SR 7 , \u2014N(R 7 )(CH 2 ) b N(R 7 ) 2 , \u2014N(R 7 )COR 7 , \u2014C(O)R 7 , \u2014C(O)OR 7 , \u2014OC(O)R 7 , \u2014OC(O)OR 7 , \u2014S(O)R 7 , \u2014S(O) 2 R 7 , \u2014S(O) 2 N(R 7 ) 2 , \u2014SO 2 C(halo) 3 , \u2014SO 2 (3- to 7-membered)heterocycle, \u2014CON(R 7 ) 2 , \u2014(C 1 -C 5 )alkyl-C\u2550NOR 7 , \u2014(C 1 -C 5 )alkyl-C(O)\u2014N(R 7 ) 2 , \u2014(C 1 -C 6 )alkyl-NHSO 2 N(R 7 ) 2 , or \u2014(C 1 -C 6 )alkyl-C(\u2550NH)\u2014N(R 7 ) 2 ; \n each R 20  is independently \u2014H, \u2014(C 1 -C 6 )alkyl, or \u2014(C 3 -C 8 )cycloalkyl; \n each halo is independently \u2014F, \u2014Cl, \u2014Br, or \u2014I; \n n is the integer 1, 2, or 3; \n p is the integer 1 or 2; \n each b is independently 1 or 2; \n q is the integer 0, 1, 2, 3, or 4; \n r is the integer 0, 1, 2, 3, 4, 5, or 6; \n s is the integer 0, 1, 2, 3, 4, or 5; \n t is the integer 0, 1, 2, or 3; and \n m is the integer 0, 1, or 2.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 86.0
- Lexical Diversity: 1.925
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14498724', '13396450', '12110155', '15179612', '14237848']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8820995527071867
- 35 USC 102 Novelty (BERT): 0.7536800387703219
- Combined Prediction Score: 0.8692576013135003
- Mean Citation Score: 842.7405679999997
- Max Citation Score: 945.5279
- Similarity Product: 849.2656973688423

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test