PATENT CLAIM ANALYSIS

Application Number: 15945696
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["525", "054100"]

Abstract:
Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.

Claim (Index 1):
A method of making polypeptide-polymer conjugates having one or more altered pharmacological properties from a plurality of polypeptides having C-termini, the method comprising:\n (a) contacting the plurality of polypeptides with a sortase and an initiator agent under conditions that permit attachment of the initiator agent to the C-terminus to form a plurality of macroinitiators; and (b) incubating the plurality of macroinitiators with a monomer under conditions that permit free-radical polymerization to occur from the initiator agent to form polypeptide-polymer conjugates, such that at least about 25% of the polypeptides have a conjugated polymer initiated solely from the C-terminus, wherein the polypeptide-polymer conjugates have an altered pharmacological property selected from at least one of (i) an in vivo half-life that is at least 25% greater compared with the in vivo half life of the plurality of polypeptides; and (ii) an in vivo biodistribution to a tissue, organ or disease site that is at least 25% greater than the in vivo biodistribution of the plurality of polypeptides.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 91.0
- Lexical Diversity: 1.35135
- Patent Class: 525.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14894731', '13201502', '15387536', '15387540', '14890241']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.598593592312668
- 35 USC 102 Novelty (BERT): 0.5875128314030252
- Combined Prediction Score: 0.5974855162217038
- Mean Citation Score: 336.906758
- Max Citation Score: 495.40408
- Similarity Product: 493.19901838083257

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test