PATENT CLAIM ANALYSIS

Application Number: 16118864
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["435", "006120"]

Abstract:
The invention provides methods for isolating RNA from the soluble fraction of urine. The methods can be used for detecting the presence or absence of an RNA, or quantifying the amount of an RNA. The methods are useful for diagnosing an individual suspected of having a disease by detecting the level of RNA associated with the disease in the soluble fraction of urine. The methods are also useful for prognosing an individual diagnosed with a disease by detecting the level of RNA associated with the disease in the soluble fraction of urine.

Claim (Index 23):
A method for processing urine for detection of RNA expression associated with a cancer, comprising:\n a) separating urine sediment from the soluble urine fraction of a urine sample obtained from an individual suspected of having cancer, wherein RNA associated with the cancer is present in the soluble urine fraction; and b) concentrating the soluble urine fraction by ultrafiltration to produce a soluble urine concentrate, wherein the volume of the soluble urine concentrate is reduced at least 50% from the original urine volume, wherein the cancer-associated RNA is selected from the group consisting of prostate cancer antigen 3 (PCA3), p antigen family, member 4 (PAGE4), solute carrier family 45, member 3 (SLC45A3), kallikrein-related peptidase, member 3 (KLK3), phosphoinositide-3-kinase, alpha polypeptide (PIK3CA), erythroblastic leukemia viral oncogene homolog 2 (ERBB2), hyaluronoglucosaminidase (HYAL1), bladder cancer associated protein (BLCAP), solute carrier family 35, member E3 (SLC35E3), tumor protein p53 (TP53), and suppressor of tumorigenicity 20 (ST20).

Metadata:
- Claim Count in Document: 56.0
- Percentile: 96.0
- Lexical Diversity: 2.36585
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12973747', '15130039', '15593921', '15952452', '13997868']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6458674585454783
- 35 USC 102 Novelty (BERT): 0.5742589432080731
- Combined Prediction Score: 0.6387066070117379
- Mean Citation Score: 450.409278
- Max Citation Score: 462.43637
- Similarity Product: 423.0121442116565

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test