PATENT CLAIM ANALYSIS

Application Number: 16373718
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-09
Patent Classification: ["424", "093200"]

Abstract:
The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant AAV (rAAV) to an animal having at least one transgene that expresses a small interfering nucleic acid or at least one binding site for a miRNA.

Claim (Index 21):
An isolated nucleic acid engineered to express a messenger RNA (mRNA) in a target tissue in a subject, wherein the mRNA contains a 3\u2032 untranslated region (UTR) comprising at least one binding site of a microRNA (miRNA) expressed endogenously in an off-target tissue in the subject, and wherein the mRNA is flanked by adeno-associated virus (AAV) inverted terminal repeat sequences (ITRs), wherein the nucleic acid encoding the mRNA is operably linked to a promoter, and wherein the at least one binding site is a binding site of a miRNA selected from: miR-1, miR-15a, miR-16-1, miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, miR-21, miR-29a/b/c, miR-30b, miR-31, miR-34a, miR-92a-1, miR-106a, miR-122, miR-125a/b, miR-132, miR-142-3p, miR-146a, miR-150, miR-155, miR-181a, miR-223 and miR-424, miR-221, miR-222, let-7i, miR-148, miR-152, or any combination thereof.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 100.0
- Lexical Diversity: 1.34615
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15423720', '15423702', '14940574', '12686097', '15127757']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8020450847310983
- 35 USC 102 Novelty (BERT): 0.7324275091745672
- Combined Prediction Score: 0.7950833271754452
- Mean Citation Score: 743.8466900000003
- Max Citation Score: 839.8097
- Similarity Product: 796.5556272737027

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test