PATENT CLAIM ANALYSIS

Application Number: 16028140
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-06
Patent Classification: ["424", "133100"]

Abstract:
The present inventors newly discovered that even if an antigen-binding molecule inhibits in vitro some of the physiological activities of an antigen having two or more physiological activities without inhibiting the remaining physiological activities, the molecule can promote elimination of the antigen from blood (from serum or plasma) and as a result reduce the physiological activities in vivo, when the antigen-binding molecule is conferred with the properties: (i) of binding to human FcRn wider an acidic pH range condition; (ii) of binding under a neutral pH range condition to human Fc receptor stronger than native human IgG, and (iii) that its antigen-binding activity alters according to the ion concentration.

Claim (Index 64):
The method of  claim 63 , wherein the one or more positions include at least one of the following positions (all by EU numbering), substituted with the indicated amino acid:\n position 221: Lys or Tyr; position 222: Phe, Trp, Glu, or Tyr; position 223: Phe, Trp, Glu, or Lys; position 224: Phe, Trp, Glu, or Tyr; position 225: Glu, Lys, or Trp; position 227: Glu, Gly, Lys, or Tyr; position 228: Glu, Gly, Lys, or Tyr; position 230: Ala, Glu, Gly, or Tyr; position 231: Glu, Gly, Lys, Pro, or Tyr; position 232: Glu, Gly, Lys, or Tyr; position 233: Ala, Asp, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 234: Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 235: Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 236: Ala, Asp, Glu, Phe, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 237: Ala, Asp, Glu, Phe, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 238: Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 239: Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Thr, Val, Trp, or Tyr; position 240: Ala, Ile, Met, or Thr; position 241: Asp, Glu, Leu, Arg, Trp, or Tyr; position 243: Leu, Glu, Leu, Gln, Arg, Trp, or Tyr; position 244: His; position 245: Ala; position 246: Asp, Glu, His, or Tyr; position 247: Ala, Phe, Gly, His, Ile, Leu, Met, Thr, Val, or Tyr; position 249: Glu, His, Gln, or Tyr; position 250: Glu or Gln; position 251: Phe; position 254: Phe, Met, or Tyr; position 255: Glu, Leu, or Tyr; position 256: Ala, Met, or Pro; position 258: Asp, Glu, His, Ser, or Tyr; position 260: Asp, Glu, His, or Tyr; position 262: Ala, Glu, Phe, Ile, or Thr; position 263: Ala, Ile, Met, or Thr; position 264: Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Trp, or Tyr; position 265: Ala, Glu, Leu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 266: Ala, Phe, Ile, Leu, Met, or Thr; position 267: Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Thr, Val, Trp, or Tyr; position 268: Ala, Asp, Glu, Phe, Gly, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Thr, Val, or Trp; position 269: Asp, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Arg, Ser, Thr, Val, Trp, or Tyr; position 270: Glu, Phe, Gly, His, Ile, Leu, Met, Pro, Gln, Arg, Ser, Thr, Trp, or Tyr; position 271: Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 272: Asp, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 273: Phe or Ile; position 274: Asp, Glu, Phe, Gly, His, Ile, Leu, Met, Asn, Pro, Arg, Ser, Thr, Val, Trp, or Tyr; position 275: Leu or Trp; position 276: Asp, Glu, Phe, Gly, His, Ile, Leu, Met, Pro, Arg, Ser, Thr, Val, Trp, or Tyr; position 278: Asp, Glu, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, or Trp; position 279: Ala; position 280: Ala, Gly, His, Lys, Leu, Pro, Gln, Trp, or Tyr; position 281: Asp, Lys, Pro, or Tyr; position 282: Glu, Gly, Lys, Pro, or Tyr; position 283: Ala, Gly, His, Ile, Lys, Leu, Met, Pro, Arg, or Tyr; position 284: Asp, Glu, Leu, Asn, Thr, or Tyr; position 285: Asp, Glu, Lys, Gln, Trp, or Tyr; position 286: Glu, Gly, Pro, or Tyr; position 288: Asn, Asp, Glu, or Tyr; position 290: Asp, Gly, His, Leu, Asn, Ser, Thr, Trp, or Tyr; position 291: Asp, Glu, Gly, His, Ile, Gln, or Thr; position 292: Ala, Asp, Glu, Pro, Thr, or Tyr; position 293: Phe, Gly, His, Ile, Leu, Met, Asn, Pro, Arg, Ser, Thr, Val, Trp, or Tyr; position 294: Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Arg, Ser, Thr, Val, Trp, or Tyr; position 295: Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Arg, Ser, Thr, Val, Trp, or Tyr; position 296: Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, or Val; position 297: Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 298: Ala, Asp, Glu, Phe, His, Ile, Lys, Met, Asn, Gln, Arg, Thr, Val, Trp, or Tyr; position 299: Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Val, Trp, or Tyr; position 300: Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, or Trp; position 301: Asp, Glu, His, or Tyr; position 302: Ile; position 303: Asp, Gly, or Tyr; position 304: Asp, His, Leu, Asn, or Thr; position 305: Glu, Ile, Thr, or Tyr; position 311: Ala, Asp, Asn, Thr, Val or Tyr; position 313: Phe; position 315: Leu; position 317: Glu or Gln; position 318: His, Leu, Asn, Pro, Gln, Arg, Thr, Val, or Tyr; position 320: Asp, Phe, Gly, His, Ile, Leu, Asn, Pro, Ser, Thr, Val, Trp, or Tyr; position 322: Ala, Asp, Phe, Gly, His, Ile, Pro, Ser, Thr, Val, Trp, or Tyr; position 323: Ile, Leu, or Met; position 324: Asp, Phe, Gly, His, Ile, Leu, Met, Pro, Arg, Thr, Val, Trp, or Tyr; position 325: Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 326: Ala, Asp, Glu, Phe, Gly, His, Ile, Leu, Met, Asn, Pro, Gln, Ser, Thr, Val, Trp, or Tyr; position 327: Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Arg, Thr, Val, Trp, or Tyr; position 328: Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 329: Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 330: Cys, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Arg, Ser, Thr, Val, Trp, or Tyr; position 331: Asp, Phe, His, Ile, Leu, Met, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 332: Ala, Asp, Glu, Phe, Gly, His, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 333: Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Pro, Arg, Ser, Thr, Val, or Tyr; position 334: Ala, Glu, Phe, His, Ile, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr; position 335: Asp, Phe, Gly, His, Ile, Leu, Met, Asn, Pro, Arg, Ser, Val, Trp, or Tyr; position 336: Glu, Lys, or Tyr; position 337: Asp, Glu, His, or Asn; position 339: Asp, Phe, Gly, Ile, Lys, Met, Asn, Gln, Arg, Ser, or Thr; position 376: Ala or Val; position 377: Gly or Lys; position 378: Asp; position 379: Asn; position 380: Ala, Asn, or Ser; position 382: Ala or Ile; position 385: Glu; position 392: Thr; position 396: Asp, Glu, Phe, Ile, Lys, Leu, Met, Gln, Arg, or Tyr; position 421: Lys; position 427: Asn; position 428: Phe or Leu; position 429: Met; position 434: Trp; position 436: Ile; position 440: Gly, His, Ile, Leu, or Tyr.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 95.0
- Lexical Diversity: 1.5974
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14007947', '14347448', '14101441', '13650493', '09825517']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7847166050914735
- 35 USC 102 Novelty (BERT): 0.7142565891463679
- Combined Prediction Score: 0.7776706034969629
- Mean Citation Score: 761.1392320000001
- Max Citation Score: 1081.3811
- Similarity Product: 753.9033883390665

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test