PATENT CLAIM ANALYSIS

Application Number: 15745441
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "026000"]

Abstract:
Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.

Claim (Index 34):
A method of treating a heart condition in a subject in need thereof, comprising co-administering to the subject a therapeutically effective amount of:\n an agent selected from the group consisting of a \u03b2-blocker, an anticoagulation agent, an angiotensin-converting-enzyme inhibitor and an angiotensin II receptor antagonist; and a compound represented by Formula III: including any pharmaceutically acceptable salt, prodrug, hydrate, solvate, enantiomer and diastereomer thereof, and any mixtures thereof, wherein:\n X is H or OH; \n R\u2032 is selected from the group consisting of OH, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl (C 1 -C 6  alkyl substituted with at least one halo), \u2014(CR b R c )nSi(R a ) 3 , \u2014(CR b R c )n-C(=Y)\u2014NR 1 R 2 , \u2014(CR b R c )n-C(=Y)\u2014NHOH, \u2014(CR d R e )n-C(=Y)\u2014COOR 3 , \u2014NHC(=Y)NR 1 R 2  and \u2014(CR b R c )n-NH 2 ; \n Y is O or S; \n R 1 , R 2  and R 3  are each independently H or a C 1 -C 4  alkyl; \n Ra is a C 1 -C 4  alkyl; \n Rb, Rc and Rd are each independently selected from H, a C 1 -C 4  alkyl and a C 1 -C4 hydroxyalkyl; \n Re is selected from a C 1 -C 4  alkyl and a C 1 -C 4  hydroxyalkyl; and \n n is 0, 1 or 2; \n or R\u2032 is represented by general Formula II: \n A is a spacer moiety or a covalent bond; and B is a cyclic moiety, or B is selected from the group consisting of an alkylsulfonyl, an arylsulfonyl and a sulfonamide, or B is \u2014NR 1 R 2 , wherein R 1  and R 2  are each independently H or a C 1 -C 4  alkyl provided that at least one of R 1  and R 2  is a C 1 -C 4  alkyl.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 86.0
- Lexical Diversity: 1.22857
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14913366', '15276479', '15326262', '13697302', '10911300']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7351992482657781
- 35 USC 102 Novelty (BERT): 0.5229148447388141
- Combined Prediction Score: 0.7139708079130818
- Mean Citation Score: 217.841656
- Max Citation Score: 302.30185
- Similarity Product: 177.93704307684305

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test