PATENT CLAIM ANALYSIS

Application Number: 16025832
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "006200"]

Abstract:
A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, includes at least a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and a dextran substituted by radicals carrying carboxylate charges and hydrophobic radicals. Single-dose formulations at a pH of between 7 and 7.8 includes a basal insulin whose isoelectric point is between 5.8 and 8.5 and a prandial insulin.

Claim (Index 1):
A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, comprising at least:\n a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and b) dextran polymers substituted by radicals carrying carboxylate charges and hydrophobic radicals of formula I or of formula II: in which:\n R is \u2014OH or chosen from the group consisting of the radicals:\n -(f-[A]-COOH) n ; and \n -(g-[B]-k-[D]) m , D comprising at least one alkyl chain comprising at least 8 carbon atoms; wherein: \n \n n represents the degree of substitution of the glucoside units by -f-[A]-COOH and 0.3\u2264n\u22642; \n m represents the degree of substitution of the glucoside units by -g-[B]-k-[D] and 0.02<m\u22640.2; \n q represents the degree of polymerization as glucoside units, that is to say the mean number of glucoside units per polysaccharide chain, and 3\u2264q\u226440;\n -A- is a linear or branched radical comprising from 1 to 4 carbon atoms; the said -A- radical: \n being bonded to a glucoside unit via a functional group f chosen from the group consisting of ether, ester and carbamate functional groups; \n -B- is a linear or branched, at least divalent, radical comprising from 1 to 4 carbon atoms; the said -B- radical: \n being bonded to a glucoside unit via a functional group g chosen from the group consisting of ether, ester and carbamate functional groups; \n being bonded to a -D radical via a functional group k; k chosen from the group consisting of ester, amide and carbamate functional groups; the said -D radical:\n being an -X(-l-Y) p  radical, X being an at least divalent radical comprising from 1 to 12 atoms chosen from the group consisting of C, N and O atoms, optionally carrying carboxyl or amine functional groups; Y being a linear or cyclic alkyl group, an alkylaryl or an arylalkyl, of 8 to 30 carbon atoms, optionally substituted by one or several C1 to C3 alkyl groups; p\u22651 and 1 a functional group chosen from the group consisting of ester, amide and carbamate functional groups; \n \n \n f, g and k being identical or different; \n the free acid functional groups being in the form of salts of alkali metal cations chosen from the group consisting of Na +  and K + ; \n and, when p=1, if Y is a C 8  to C 14  alkyl, then q*m\u22652, if Y is a C 15  alkyl, then q*m\u22652; if Y is a C 16  to C 20  alkyl, then q*m\u22651; and if Y is a C 21  to C 30  group, then q*m\u22651; \n and, when p\u22652, if Y is a C 8  to C 9  alkyl, then q*m\u22652 and, if Y is a C 10  to C 16  alkyl, then q*m\u22650.2; \n in which:\n R is \u2014OH or a -(f-[A]-COOH) n  radical:\n -A- is a linear or branched radical comprising from 1 to 4 carbon atoms; the said radical -A-: \n being bonded to a glucoside unit via a functional group f chosen from the group consisting of ether, ester or carbamate functional groups; \n n represents the degree of substitution of the glucoside units by -f-[A]-COOH and 0.3\u2264n\u22642; \n \n R\u2032 is chosen from the group consisting of the radicals:\n \u2014C(O)NH-[E]-(o-[F]) t ; and \n \u2014CH 2 N(L) z -[E]-(o-[F]) t ; \n \n in which:\n z is a positive integer equal to 1 or 2, \n L is chosen from the group consisting of:\n \u2014H and z is equal to 1, and/or \n -[A]-COOH and z is equal to 1 or 2, if f is an ether functional group, \n \u2014CO-[A]-COOH and z is equal to 1 if f is an ester functional group, and \n \u2014CO\u2014NH-[A]-COOH and z is equal to 1 if f is a carbamate functional group; \n \n -[E]-(o-[F]) t :\n -E- is a linear or branched, at least divalent, radical comprising from 1 to 8 carbon atoms and optionally comprising heteroatoms, such as O, N or S; \n -F- is a linear or cyclic alkyl group, an alkylaryl or an arylalkyl, of 12 to 30 carbon atoms, optionally substituted by one or several C1 to C3 alkyl groups; \n o is a functional group chosen from the group consisting of ether, ester, amide or carbamate functional groups; \n t is a positive integer equal to 1 or 2; \n \n q represents the degree of polymerization as glucoside units, that is to say the mean number of glucoside units per polysaccharide chain, and 3\u2264q\u226440; \n the free acid functional groups being in the form of salts of alkali metal cations chosen from the group consisting of Na +  and K + ; and \n when z=2, the nitrogen atom is in the form of a quaternary ammonium.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 95.0
- Lexical Diversity: 1.77778
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13571026', '15899795', '15616470', '15616128', '14922663']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8174910072575228
- 35 USC 102 Novelty (BERT): 0.7292443002387864
- Combined Prediction Score: 0.8086663365556491
- Mean Citation Score: 575.206164
- Max Citation Score: 816.0116
- Similarity Product: 805.6262995511532

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test