PATENT CLAIM ANALYSIS

Application Number: 16372358
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-07
Patent Classification: ["435", "363000"]

Abstract:
The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.

Claim (Index 1):
A composition comprising human pluripotent stem cells and a medium comprising an effective amount of a soluble human serum attachment component, wherein:\n the human pluripotent stem cells are in contact with the medium in a culture vessel that is not pre-coated with an extracellular matrix; \n the effective amount of the soluble human serum attachment component promotes growth of the human pluripotent stem cells; and \n the medium comprises one or more growth factors selected from the group consisting of a fibroblast growth factor (bFGF), an acidic fibroblast growth factor (aFGF), an epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II), a platelet-derived growth factor-AB (PDGF), a vascular endothelial cell growth factor (VEGF), activin-A, a bone morphogenic protein (BMPs), a cytokine, a chemokine, a morphogen, a neutralizing antibody, and a heregulin.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 100.0
- Lexical Diversity: 1.66667
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15050069', '11875057', '14102451', '11838054', '13409059']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6389144432241475
- 35 USC 102 Novelty (BERT): 0.6132311622283312
- Combined Prediction Score: 0.6363461151245658
- Mean Citation Score: 444.51085600000016
- Max Citation Score: 567.945
- Similarity Product: 513.5984038513899

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test