PATENT CLAIM ANALYSIS

Application Number: 15754061
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-12
Patent Classification: ["514", "04400A"]

Abstract:
The disclosure includes methods of determining the activity of an inhibitor of a target microRNA (miRNA) or of a mimic of a target microRNA. Determination of polysome occupancy in treated and control samples followed by comparing the occupancies can be used to determine a displacement value for the inhibitor or mimic of the target miRNA. The displacement value reflects the extent of a change in the levels of the target miRNA (which may include the mimic if applicable) in polysomal and non-polysomal compartments of a sample or a shift of the target miRNA between polysomal and non-polysomal compartments of a sample and can indicate the activity of the inhibitor toward the target miRNA or of the mimic toward a target RNA.

Claim (Index 9):
A method for determining the activity of a mimic of a target microRNA comprising:\n a. determining a polysome occupancy in a treated sample; b. determining a polysome occupancy in a control sample; c. comparing the polysome occupancy in the treated sample to the polysome occupancy in the control sample to determine a displacement value for the mimic of the target microRNA, thereby determining the activity of the mimic of the target microRNA.

Metadata:
- Claim Count in Document: 46.0
- Percentile: 88.0
- Lexical Diversity: 2.24561
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13964705', '14866186', '11100897', '13415685', '14061350']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7129006715077799
- 35 USC 102 Novelty (BERT): 0.5103502490070806
- Combined Prediction Score: 0.69264562925771
- Mean Citation Score: 251.677988
- Max Citation Score: 263.2443
- Similarity Product: 171.32274551342726

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test