PATENT CLAIM ANALYSIS

Application Number: 15863498
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-07
Patent Classification: ["514", "183000"]

Abstract:
This invention describes the use of indane acetic acid derivatives which are dual PPAR delta/gamma agonists, and which penetrate the Blood Brain Barrier and achieve effective brain to plasma drug levels at non-toxic doses, for the treatment of neurodegenerative diseases including one or more of the following: Alzheimer's Disease (AD); Huntington's Disease (HD); Parkinson's Disease (PD); Amyotrophic Lateral Sclerosis (ALS); Frontal Temporal Dementia (FTD); Corticobasal Degeneration (CBD); Progressive Supranuclear Palsey (PSP); Dementia with Lewy Bodies (DLB); or Multiple Sclerosis (MS).

Claim (Index 2):
The method of treatment according to  claim 1 , wherein the dual PPAR delta and gamma agonist, which penetrates the blood brain barrier (BBB), and achieves pharmacologically useful concentrations in the brain, is of Formula I, or is a pharmaceutically acceptable salt, ester prodrug, stereoisomer, enantiomer, racemate or a combination thereof wherein Formula I is: wherein R is H, Na + , Li + , Ca + , K + , N + (C1-C6) 4 , or C1-C6 alkyl; R 1  is H, \u201cc-2\u201d is defined as the second carbon of the acetic acid portion of Formula I, and \u201cc-1\u2032\u201d is the first carbon of the indane group of Formula I; R 2  is H, halo, or C 1 -C 6  alkyl which may be unsubstituted or substituted with C 1 -C 6  alkoxy, oxo, fluoro; R 3  is H, C 1 -C 6  alkyl, or phenyl, which may be unsubstituted or substituted with R 6 ; X is O or S; R 4  is phenyl, which may be unsubstituted or singularly or multiply substituted with R 6 ; R 5  is H, halo or C 1 -C 6  alkyl optionally substituted with C 1 -C 6  alkoxy, oxo, fluoro; R 6  is halo, CF 3 , C 1 -C 6  alkyl optionally substituted with oxo or hydroxy, or C 1 -C 6  alkoxy optionally substituted with fluoro; wherein R 3  may be attached to the heterocyclic moiety of the compound of Formula I at either the 4 or 5 position and, accordingly, the remaining portion of the molecule will be attached at the remaining available carbon atom.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 91.0
- Lexical Diversity: 1.50667
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15774638', '15830675', '15484445', '14429101', '14897396']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7798368264806159
- 35 USC 102 Novelty (BERT): 0.503216254220504
- Combined Prediction Score: 0.7521747692546048
- Mean Citation Score: 249.04305400000004
- Max Citation Score: 259.62888
- Similarity Product: 192.2921951156616

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test