PATENT CLAIM ANALYSIS

Application Number: 16025377
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["800", "008000"]

Abstract:
Non-human animals comprising a human or humanized C3 and/or C5 nucleic acid sequence are provided as well as methods for using the same to identify compounds capable of modulating the complement system. Non-human animals that comprise a replacement of the endogenous C5 gene and/or C3 gene with a human or humanized C5 gene and/or C3 gene, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized C5 gene under control of non-human C5 regulatory elements is also provided, including non-human animals that have a replacement of non-human C5-encoding sequence with human C5-encoding sequence at an endogenous non-human C5 locus. Non-human animals comprising a human or humanized C3 gene under control of non-human C3 regulatory elements is also provided, including non-human animals that have a replacement of non-human C3 protein-encoding sequence with human or humanized C3 protein-encoding sequence at an endogenous non-human C3 locus. Non-human animals comprising human or humanized C3 and/or C5 sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided.

Claim (Index 13):
The rodent of  claim 12 , wherein the genome of the mouse comprises a replacement of a mouse C5 gene sequence at an endogenous mouse C5 locus with a human C5 gene sequence to form a modified C5 gene, and wherein the modified C5 gene encodes the human or humanized C5 protein.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 95.0
- Lexical Diversity: 3.04918
- Patent Class: 800.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15660833', '14703818', '14706319', '15649702', '14723855']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7002743873222748
- 35 USC 102 Novelty (BERT): 0.6641467156889104
- Combined Prediction Score: 0.6966616201589383
- Mean Citation Score: 593.620496
- Max Citation Score: 756.46387
- Similarity Product: 624.1875601886053

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test