PATENT CLAIM ANALYSIS

Application Number: 15935692
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "422000"]

Abstract:
The present disclosure is directed to injectable formulations that include biodegradable polymers based on trimethylene carbonate (TMC) with mole fractions of polylactic acid (PLA) and/or polyglycolic acid (PGA) that are used to deliver a bioactive agent to a targeted site. Excipients such as polyethylene glycol (PEG) may be added to the formulations to reduce the injection force and/or to modulate the release of the bioactive agent. Suitable biodegradable polymers for use in the injectable formulations include D,L-PLA:TMC, D-PLA:TMC, L-PLA:TMC, TMC:PLA:PGA and variations thereof. Additionally, copolymers of TMC and PLA and terpolymers of TMC:PLA:PGA may be formed into nanoparticles and delivered to the target site with an injectable crosslinkable polyethylene glycol system. In at least one embodiment, the injectable formulations are used to treat ocular diseases.

Claim (Index 1):
A sustained-release formulation comprising:\n an injectable bioabsorbable polymer comprising a trimethylene carbonate (TMC)-based polymer, wherein the TMC-based polymer comprises:\n a) a copolymer comprising repeating units of trimethylene carbonate and lactide, and/or \n b) a polylactide (PLA), (TMC), polyglycolic acid (PGA) terpolymer, wherein the terpolymer comprises from 3-19 wt. % PGA and wherein the PLA:TMC weight ratio is from 3.25:1 to 0.75:1; \n a pharmaceutically acceptable excipient; a solvent selected from 1,2,3-triacetoxypropane, acetyltributyl citrate, triethyl citrate, tributyl citrate, and acetyl triethyl citrate; and a bioactive agent.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.89286
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14891574', '14124631', '14029211', '12758541', '15582685']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7058410226349211
- 35 USC 102 Novelty (BERT): 0.4919493308872081
- Combined Prediction Score: 0.6844518534601498
- Mean Citation Score: 194.20186
- Max Citation Score: 218.9938
- Similarity Product: 155.99472742476462

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test