PATENT CLAIM ANALYSIS

Application Number: 15748984
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-11
Patent Classification: ["435", "007100"]

Abstract:
The present invention is related to detecting respiratory diseases using molecular markers as prognostic tool of the evolution of respiratory infection cases. Concretely, during the differential diagnostic of respiratory infections caused by the Syncytial Respiratory Virus and human Metapneumovirus, it will be established the expression pattern of the severity markers of IL-3, IL-33 and IL12p40. The expression pattern of the molecular markers can be defined in biological samplers using ELISA assays, flow cytometry or PCR in real time. The confirmation of the etiological agent of the infection in combination to the pattern definition of the molecular markers IL-3, IL-33 and IL12p40 will indicate a prognostic of the disease severity.

Claim (Index 3):
A method for predicting recurrent wheezing and asthma after a bronchiolitis caused by the Syncytial Respiratory Virus (SRV), wherein the method consists in:\n amplifying and detecting using a procedure of molecular biology such as PCR and ELISA, utilizing markers IL-3, IL-12p40 and IL-33; quantify the overexpression of the target sequence complementary to the markers IL-3, IL-33 or IL-12p40; correlate based on the quantification of the obtained overexpression, the develop of the disease caused by SRV: High probability of developing wheezing if a concentration greater than SOOpg/ml of IL-12p40 or IL-3 is found in bronchoalveolar lavage; high probability of developing asthma if a concentration greater than SOOpg/ml of IL-33 is found in bronchoalveolar lavage.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 1.78788
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12259155', '12492494', '10958204', '14186069', '15544989']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5677159714526044
- 35 USC 102 Novelty (BERT): 0.5073690220721361
- Combined Prediction Score: 0.5616812765145576
- Mean Citation Score: 213.832898
- Max Citation Score: 243.57799
- Similarity Product: 167.8250198895413

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test