PATENT CLAIM ANALYSIS

Application Number: 15927232
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "615000"]

Abstract:
Brown adipose tissue (BAT) plays a role in keeping an organism warm in response to a cold environment. In response to cold, transcription factors, including peroxisome proliferator receptor alpha (PGC1α), mediate the adaptive changes in the expression of oxidative and thermogenic genes in BAT. However, even without cold, BAT exhibits high expression of these genes relative to white adipose tissue (WAT). It is shown herein that estrogen related receptor gamma (ERRγ) is a critical factor that controls the expression of key metabolic genes in BAT under basal conditions. ERRγ is highly expressed in BAT versus WAT, yet is not transcriptionally induced by cold, suggesting it plays an important role in innate basal BAT function rather than in the adaptive response to cold. Based on these observations, methods of increasing thermogenesis in a subject by administering a therapeutically effective amount of one or more agents that increase ERRγ activity are provided.

Claim (Index 9):
The method of  claim 1 , wherein the one or more agents that increase ERR\u03b3 activity is: or combinations thereof.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 90.0
- Lexical Diversity: 1.73737
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13410142', '12446110', '14376209', '14389374', '14896787']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7808383404809033
- 35 USC 102 Novelty (BERT): 0.5081195671097029
- Combined Prediction Score: 0.7535664631437833
- Mean Citation Score: 254.981538
- Max Citation Score: 305.3798
- Similarity Product: 279.75434700628523

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test