PATENT CLAIM ANALYSIS

Application Number: 15956835
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["540", "555000"]

Abstract:
The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.

Claim (Index 42):
A method of preparing a compound of formula (III): or a salt thereof, comprising the steps of:\n a) reacting the compound of formula (II): \n with Fe in the presence of NH 4 Cl to form a compound of formula (I): \u2003and\n b) reacting the compound of formula (I) with a hydrogenation reagent in the presence of a palladium catalyst to form the compound of formula (III), wherein: \n R 1 , R 2 , R 3 , and R 4  are each independently selected from the group consisting of \u2014H, an optionally substituted linear, branched or cyclic alkyl, alkenyl or alkynyl having from 1 to 10 carbon atoms, \u2014(CH 2 CH 2 X) n \u2014R c , halogen, \u2014NH(C\u2550NH)NH 2 , \u2014OR, \u2014NR\u2032R\u2033, \u2014NCO, \u2014NR\u2032COR\u2033, \u2014SR, \u2014SOR\u2032, \u2014SO 2 R\u2032, \u2014SO 3 H, \u2014OSO 3 H, \u2014SO 2 NR\u2032R\u2033, cyano, azido, \u2014COR\u2032, \u2014OCOR\u2032, and \u2014OCONR\u2032R\u2033; \n X is selected from O, NH and S; \n R 5  is \u2014H, \u2014R, \u2014OR, \u2014SR, \u2014NR\u2032R\u2033, or halogen; \n R, for each occurrence, is independently selected from the group consisting of \u2014H, an optionally substituted linear, branched or cyclic alkyl, alkenyl or alkynyl having from 1 to 10 carbon atoms, a polyethylene glycol unit \u2014(CH 2 CH 2 X) n \u2014R c , an optionally substituted aryl having 6 to 18 carbon atoms, an optionally substituted 5- to 18-membered heteroaryl ring containing one or more heteroatoms independently selected from nitrogen, oxygen, and sulfur, or an optionally substituted 3- to 18-membered heterocyclic ring containing 1 to 6 heteroatoms independently selected from O, S, N and P; \n R\u2032 and R\u2033 are each independently selected from \u2014H, \u2014OH, \u2014OR, \u2014NHR, \u2014NR 2 , \u2014COR, an optionally substituted linear, branched or cyclic alkyl, alkenyl or alkynyl having from 1 to 10 carbon atoms, a polyethylene glycol unit \u2014(CH 2 CH 2 X) n \u2014R c , and an optionally substituted 3- to 18-membered heterocyclic ring having 1 to 6 heteroatoms independently selected from O, S, N and P; \n R c  is \u2014H or a substituted or unsubstituted linear or branched alkyl having 1 to 4 carbon atoms; and \n n is an integer from 1 to 24.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 91.0
- Lexical Diversity: 1.0
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13397195', '14849270', '13984762', '14843520', '15581749']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6599570177538236
- 35 USC 102 Novelty (BERT): 0.5248040784693193
- Combined Prediction Score: 0.6464417238253732
- Mean Citation Score: 296.88886999999994
- Max Citation Score: 299.48282
- Similarity Product: 208.81443451661588

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test