PATENT CLAIM ANALYSIS

Application Number: 16100055
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2020-02
Patent Classification: ["null", "null"]

Abstract:
The invention relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets that are coated with a diffusion-controlled inner coating and an enteric outer coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption.

Claim (Index 1):
An oral dosage form comprising:\n a) a plurality of pellets, each pellet comprising at least 70% w/w cholestyramine and\n i. a combination of at least 6% w/w of a vinylpyrrolidone-based polymer and at least 2% w/w of an acrylate copolymer; or \n ii. a combination of at least 5% w/w of a vinvlpyrrolidone-based polymer and at least 3% w/w of an acrylate copolymer; or \n iii. a combination of at least 6% w/w of a vinylpyrrolidone-based polymer, at least 1% w/w of an acrylate copolymer and at least 10% w/w microcrystalline cellulose; \n b) a diffusion-controlled inner coating surrounding each pellet; and c) an enteric outer coating; wherein the oral dosage form exhibits less than about 30% sequestration of cholic acid, chenodeoxycholic acid, and deoxycholic acid after 2 hours in small intestinal incubations (\u201cSI-2\u201d) as measured in a Simulator of the Human Intestinal Microbial Ecosystem (SHIME) model.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 96.0
- Lexical Diversity: 1.42105
- Patent Class: nan
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15988281', '15449781', '15988560', '15449645', '11804259']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.545047239227972
- 35 USC 102 Novelty (BERT): 0.5886641404253712
- Combined Prediction Score: 0.549408929347712
- Mean Citation Score: 387.067998
- Max Citation Score: 548.3304400000002
- Similarity Product: 455.3181328591039

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test