PATENT CLAIM ANALYSIS

Application Number: 16031819
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["435", "440000"]

Abstract:
Compositions and methods for using nucleosome interacting protein domains to increase accessibility of programmable DNA modification proteins to target chromosomal sequences, thereby increasing efficiency of targeted genome/epigenetic modification in eukaryotic cells.

Claim (Index 1):
A fusion protein comprising a clustered regularly interspersed short palindromic repeats (CRISPR) protein linked to at least one nucleosome interacting protein domain, wherein the CRISPR protein is a type II CRISPR/Cas9 nuclease and the at least one nucleosome interacting protein domain is a high mobility group (HMG) box (HMGB) DNA binding domain, a HMG nucleosome-binding (HMGN) protein, a central globular domain from a histone H1 variant, or a combination thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.1
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15437148', '14105017', '15179912', '15935334', '15369533']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5686625799227691
- 35 USC 102 Novelty (BERT): 0.5345126856712701
- Combined Prediction Score: 0.5652475904976193
- Mean Citation Score: 363.518024
- Max Citation Score: 385.41925
- Similarity Product: 273.4525054850578

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test