PATENT CLAIM ANALYSIS

Application Number: 15893259
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-08
Patent Classification: ["250", "282000"]

Abstract:
The invention pertains to materials and methods for identifying and/or isolating isomers, particularly, of biomolecules, such as polypeptides and proteins. The methods of identifying and/or isolating isomers of a molecule according to the invention comprise subjecting a sample to ionization prior to IMS followed by MS. In some embodiments, the sample is subjected to metallization during the ionization step.

Claim (Index 19):
A method of identifying in a biological sample an unknown isomer of a known biomolecule, the method comprising the steps of:\n i) subjecting the biological sample to a step of ionization comprising subjecting the biological sample to a step of metalation with ions of one or more transition metal(s) having one or more oxidation state(s) and optionally, further with ions of one or more alkali metal(s) and/or one or more alkaline earth metal(s), ii) after step i), subjecting the sample to a step of IMS comprising a step of tandem non-linear IMS and a step of linear high resolution IMS, iii) after step ii), subjecting the sample to a step of MS, and iv) identifying and optionally, isolating, molecules from the biological sample that have similar but not identical behavior to the known biomolecule in the IMS and MS steps, the step of IMS followed by the step of MS separating the known and unknown isomers of the known biomolecule based on unique collision cross sections of the ionic complexes formed between the known and unknown isomers of the known biomolecule and the one or more transition metal(s).

Metadata:
- Claim Count in Document: 51.0
- Percentile: 88.0
- Lexical Diversity: 1.57143
- Patent Class: 250.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13881684', '14477726', '15330635', '15519126', '10175486']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6847184870307624
- 35 USC 102 Novelty (BERT): 0.4912737950182684
- Combined Prediction Score: 0.6653740178295131
- Mean Citation Score: 185.939378
- Max Citation Score: 205.25795
- Similarity Product: 135.71925764454602

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test