PATENT CLAIM ANALYSIS

Application Number: 16111158
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-04
Patent Classification: ["424", "174100"]

Abstract:
The present invention relates to compositions and methods for immunotherapy of a subject afflicted with diseases such as cancer, an infectious disease, or a neurodegenerative disease, which methods comprise administering to the subject a composition comprising a therapeutically effective amount of an anti-PD-L1 antibody or portion thereof that potentiates an endogenous immune response, either stimulating the activation of the endogenous response or inhibiting the suppression of the endogenous response.

Claim (Index 1):
An antibody which binds to human PD-L1 protein, the antibody selected from the group consisting of:\n (1) an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 19, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 20, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 21, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 22, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 23, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 24; (2) an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 25, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 26, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 27, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 28, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 29, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 30; (3) an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 31, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 32, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 33, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 34, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 35, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 36; (4) an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 37, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 38, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 39, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 40, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 41, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 42; (5) an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 43, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 44, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 45, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 46, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 47, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 48; (6) an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 49, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 50, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 51, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 52, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 53, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 54; (7) an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 55, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 56, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 57, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 58, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 59, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 60; (8) an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 61, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 62, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 63, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 64, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 65, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 66; and (9) an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 67, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 68, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 69, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO: 70, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO: 71, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO: 72.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 96.0
- Lexical Diversity: 1.5102
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15620771', '15328232', '15328225', '15744737', '16100019']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7545381486709611
- 35 USC 102 Novelty (BERT): 0.6127882458762232
- Combined Prediction Score: 0.7403631583914874
- Mean Citation Score: 479.97426400000006
- Max Citation Score: 535.1266
- Similarity Product: 512.8175591056108

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test