PATENT CLAIM ANALYSIS

Application Number: 16315710
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["514", "235200"]

Abstract:
The present invention relates to a compound of the formula: where n, R and R are those defined herein. The present invention also relates to use of a compound of Formula 1 in treating a clinical condition associated with fibrotic disorder.

Claim (Index 1):
A compound of the formula: wherein\n n is an integer from 0 to 4; \n each R 1  is independently selected from the group consisting of alkyl, haloalkyl, halogen, nitro, heterocycloalkyl, cycloalkyl, optionally substituted heteroaryl, optionally substituted aryl, and \u2014OR a , where each R a  is independently selected from the group consisting of hydrogen, alkyl, heteroaryl, aryl and cycloalkyl; or \n two adjacent R 1  together with carbon atoms to which they are attached to form heterocycloalkyl; \n R 2  is selected from the group consisting of:\n (a) a moiety of the formula: \n \n (b) a moiety of the formula: (c) an optionally substituted aryl; and (d) an optionally substituted heterocycloalkyl, wherein m is 1 or 2, X 1  is optionally substituted heterocycloalkyl, \u2014NR 4 R 5 , \u2014NR b SO 2 R 6 , \u2014NR b C(O)R 6 , \u2014NR b SO 2 NR 4 R 5 , or \u2014NR b CONR 4 R 5 ; X 2  is O, NR c  or S; R 3  and R 3\u2032  are each independently hydrogen or alkyl; each of R 4  or R 5  is independently hydrogen or alkyl, or R 4  and R 5  together with the nitrogen atom to which they are attached to form an optionally substituted heterocycloalkyl; each of R b  and R c  is independently hydrogen or alkyl; and R 6  is \u2014N(R d ) 2 , optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; provided that the compound is not: N-(N,N-diethylaminosulfonyl)-2-(indolin-1-yl)propane-1-amine); 1,1-diethyl-3-(2-(indolin-1yl)ethyl)urea; (N-(N,N-dimethylaminosulfonyl)-2-(indolin-1-yl)ethane-1-amine); 4-(2-(indolin-1-yl)ethyl)morpholine; 1-(2-(piperidin-1-yl)ethyl)indoline; N-(2-(indolin-1-yl)propyl)morpholine-4-sulfonamide; N-(2-(indolin-1-yl)propyl)piperidine-1-sulfonamide; 4-fluoro-N-(2-(indolin-1-yl)propyl)benzenesulfonamide; 4-fluoro-N-(2-(indolin-1-yl)ethyl)benzenesulfonamide; N-(2-(indolin-1-yl)ethyl)-4-methoxybenzenesulfonamide; 3,4-difluoro-N-(2-(indolin-1yl)propyl)benzenesulfonamide; N-(2-(indolin-1-yl)propyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide; N-(2-(indolin-1-yl)ethyl)benzo[d][1,3]dioxole-5-sulfonamide; N-(2-(indolin-1-yl)ethyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide; N,N-diethyl-4-(2-(indolin-1-yl)-2-oxoethyl)piperazine-1-sulfonamide; 1-(indolin-1-yl)-2-(4-(morpholinosulfonyl)piperazin-1-yl)ethan-1-one; 1-(indolin-1-yl)-2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethan-1-one; 4-(3-indolin-1-yl)-3-oxopropyl)-N,N-dimethylpiperazine-1-sulfonamide; N,N-diethyl-4-(3-(indolin-1-yl)-3-oxopropyl)piperazine-1-sulfonamide; 1-(indolin-1-yl)-3-(4-(morpholinosulfonyl)piperazin-1-yl)propan-1-one; 1-(indolin-1-yl)-3-(4-(pyrimidin-2-yl)piperazin-1-yl)propan-1-one; 2-(cycloheptylamino)-1-(indolin-1-yl)ethan-1-one; or 3-(cycloheptylamino)-1-(indolin-1-yl)propan-1-one.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 99.0
- Lexical Diversity: 1.36364
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15736450', '14000829', '15315461', '15738900', '10516681']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7548883748344636
- 35 USC 102 Novelty (BERT): 0.4994715554967019
- Combined Prediction Score: 0.7293466929006874
- Mean Citation Score: 234.662008
- Max Citation Score: 248.7203
- Similarity Product: 197.74042571566105

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test