PATENT CLAIM ANALYSIS

Application Number: 15933608
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "361000"]

Abstract:
Antimicrobial resistance is rising at an alarming rate. The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). Notably, the MEP pathway is present in bacteria and not mammals, which made the enzymes of the MEP pathway attractive targets for discovering new anti-infective agents due to reduced chances of off-target interactions leading to side effects. The biophysical properties of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) and 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) were determined to aid discovery of novel inhibitors. Thermal shift screening was used as an initial filter to narrow down a library of compounds with thermal shifts greater than 1° C., which could indicate binding to the IspD and IspE enzymes. Follow-up studies were performed using isothermal titration calorimetry and enzymatic inhibition assays. Results from these studies have revealed compounds with high micromolar inhibition of both IspD from  Escherichia coli  and IspE from  Burkholderia thailandensis . The hit compounds are used for future development of more potent IspD and IspE inhibitors.

Claim (Index 5):
The compound of  claim 3 , wherein R is substituted by one or more trifluoromethyl groups.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.56667
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['10474536', '14390548', '15065571', '10700003', '15124654']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7368065489934129
- 35 USC 102 Novelty (BERT): 0.5194178663851413
- Combined Prediction Score: 0.7150676807325858
- Mean Citation Score: 230.282544
- Max Citation Score: 276.67422
- Similarity Product: 190.71355194106937

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test