PATENT CLAIM ANALYSIS

Application Number: 16307362
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-07
Patent Classification: ["514", "252160"]

Abstract:
The present invention relates to the fused pyrimidine piperidine cyclic derivative represented by the following formula (I) and a pharmaceutically acceptable salt thereof and a process for preparing the same, wherein R1, R2, R3, R4, R5, X, Y and Z are defined as in the description. The present invention further provides use of said fused pyrimidine piperidine cyclic derivative in manufacture of a medicament for preventing or treating FGFR kinase mediated disease such as cancer.

Claim (Index 13):
A process for preparing the compound represented by formula (I) according to  claim 1 , which comprises the steps of: wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y and Z are defined as those in  claim 1 ; Compound Ia is used as starting material and reacted by diazotization to produce Compound Ib; Compound Ib and starting material A are reacted by coupling in a basic condition to produce Compound Ic; Compound Ic is hydrolyzed to produce Compound Id; Compound Id and DMF.DMA are reacted by formylation to produce Compound Ie; starting materials B and C are reacted by substitution in a basic condition to produce Compound If; Compound If is catalytically hydrogenated to produce Compound Ig; Compound Ig and cyanoamine are reacted by nucleophilic addition to produce Compound Ih; Compound Ih and Compound Ie are finally reacted by ring closing in a basic condition to produce the compound represented by formula (I).

Metadata:
- Claim Count in Document: 8.0
- Percentile: 98.0
- Lexical Diversity: 1.43333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15047892', '14511326', '13394525', '14132653', '14402198']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7672181249715673
- 35 USC 102 Novelty (BERT): 0.534774538798387
- Combined Prediction Score: 0.7439737663542493
- Mean Citation Score: 331.866862
- Max Citation Score: 336.3714
- Similarity Product: 206.13839922534228

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test