PATENT CLAIM ANALYSIS

Application Number: 16175758
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["800", "021000"]

Abstract:
A genetically modified mouse is provided that comprises a conditional Acvr1 allele that comprises a mutated exon that, upon induction, converts to a mutant exon phenotype, wherein the mutant exon phenotype includes ectopic bone formation. Mice comprising a mutant Acvr1 exon 5 in antisense orientation, flanked by site-specific recombinase recognition sites, are provided, wherein the mice further comprise a site-specific recombinase that recognizes the site-specific recombinase recognitions sites, wherein the recombinase is induced upon exposure of the mouse to tamoxifen. Upon exposure to tamoxifen, the recombinase is expressed and acts on the RRS-flanked mutant exon 5 and places the mutant exon 5 in sense orientation and deletes the wild-type exon.

Claim (Index 8):
A method, comprising breeding a first mouse whose genome comprises a modified mouse Activin A receptor type 1 (Acvr1) gene with a second mouse, resulting in a progeny mouse whose genome comprises the modified mouse Acvr1 gene, wherein the modified mouse Acvr1 gene comprises\n i) a human Acvr1 gene exon 5, in sense orientation and encoding glutamic acid at the first codon instead of aspartic acid, flanked upstream and downstream by a first pair of recombination recognition sites; and ii) a mouse Acvr1 gene exon 5, in antisense orientation and encoding an R206H variation, flanked upstream and downstream by a second pair of recombination recognition sites that are different than the first pair of recombination recognition sites; wherein the first and second recombination recognition sites are oriented so that a recombinase can invert the mouse Acvr1 gene exon 5 into sense orientation and delete the human Acvr1 gene exon 5, thereby producing a recombined modified mouse Acvr1 gene encoding the R206H variation, and allowing the recombined modified mouse Acvr1 gene to be expressed resulting in ectopic bone formation.

Metadata:
- Claim Count in Document: 75.0
- Percentile: 97.0
- Lexical Diversity: 2.01667
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14207320', '15983743', '16175762', '15336603', '09853033']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8134878677329731
- 35 USC 102 Novelty (BERT): 0.8063358766743951
- Combined Prediction Score: 0.8127726686271154
- Mean Citation Score: 955.718586
- Max Citation Score: 1115.7084
- Similarity Product: 1044.5271604233742

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test