PATENT CLAIM ANALYSIS

Application Number: 15756908
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "006100"]

Abstract:
The invention relates to the use of certain micro-RNAs circulating in the blood serum or blood plasma in the form of diagnostic profiles as a marker in an in vitro method for distinguishing between patients for which a myocardial biopsy is necessary for the diagnostic identification of a heart muscle disease and patients for which myocardial biopsy is not necessary, and for the optional differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases affecting the heart.

Claim (Index 2):
The in-vitro or in-vivo method as claimed in  claim 1 , wherein:\n the diagnostic profile for identifying an adenovirus-induced cardiomyopathy additionally comprises at least 3 microRNAs or synthetic nucleic acids having identical or complementary sequences, selected from the group consisting of the following microRNAs:\n hsa-miR-1274B (SEQ ID NO: 31), hsa-miR-136-3p (SEQ ID NO: 32), hsa-miR-187-3p (SEQ ID NO: 33), hsa-miR-199a-5p (SEQ ID NO: 34), hsa-miR-215-5p (SEQ ID NO: 35), hsa-miR-422a (SEQ ID NO: 36), hsa-miR-4449 (SEQ ID NO: 37), hsa-miR-4674 (SEQ ID NO: 38), hsa-miR-5096 (SEQ ID NO: 39), hsa-miR-548c-3p (SEQ ID NO: 40), hsa-miR-548c-5p (SEQ ID NO: 41), hsa-miR-650 (SEQ ID NO: 42).

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.56
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13899555', '14788843', '15320208', '13642321', '15237364']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6976434649124389
- 35 USC 102 Novelty (BERT): 0.5232194462810017
- Combined Prediction Score: 0.6802010630492952
- Mean Citation Score: 338.831186
- Max Citation Score: 342.94568
- Similarity Product: 213.5437222911549

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test