PATENT CLAIM ANALYSIS

Application Number: 15752498
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "007210"]

Abstract:
Provided are a biomarker for evaluating a cerebral Aβ accumulation state using amyloid precursor protein (APP)-derived Aβ and Aβ-like peptides in a living body-derived sample as an index, and a method for analysis thereof. A marker for determining a cerebral Aβ accumulation state, the marker comprising a combination of at least two ratios selected from the group consisting of: a ratio of Aβ1-39 (SEQ ID NO.: 1) level to Aβ1-42 (SEQ ID NO.: 3) level: Aβ1-39/Aβ1-42; a ratio of Aβ1-40 (SEQ ID NO.: 2) level to Aβ1-42 (SEQ ID NO.: 3) level: Aβ1-40/Aβ1-42; and a ratio of APP669-711 (SEQ ID NO.: 4) level to Aβ1-42 (SEQ ID NO.: 3) level: APP669-711/Aβ1-42, in a living body-derived sample.

Claim (Index 3):
An analytical method for determining efficacy of a medical intervention regarding a cerebral A\u03b2 accumulation state, the method comprising:\n conducting examination, each of before and after a medical intervention performed for a test subject, the examination including: \n a measurement step of subjecting a living body-derived sample derived from the test subject to detection of a marker containing:\n A\u03b21-42 (SEQ ID NO.: 3); \n A\u03b21-39 (SEQ ID NO.: 1); and \n at least one selected from the group consisting of A\u03b21-40 (SEQ ID NO.: 2), and APP669-711 (SEQ ID NO.: 4), \n \n to obtain measurement levels of:\n A\u03b21-42; \n A\u03b21-39; and \n the at least one selected from the group consisting of A\u03b21-40, and APP669-711, in the living body-derived sample; \n a calculation step of calculating:\n a ratio of A\u03b21-39 level to A\u03b21-42 level: A\u03b21-39/A\u03b21-42; and \n at least one ratio selected from the group consisting of:\n a ratio of A\u03b21-40 level to A\u03b21-42 level: A\u03b21-40/A\u03b21-42; and \n a ratio of APP669-711 level to A\u03b21-42 level: APP669-711/A\u03b21-42; and \n \n \n a derivation step of deriving a composite variable by a combination of each of the ratios calculated, through a mathematical technique; and \n comparing the composite variable of the test subject before the medical intervention and the composite variable of the test subject after the medical intervention to determine efficacy of the medical intervention regarding a cerebral A\u03b2 accumulation state.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 88.0
- Lexical Diversity: 2.29851
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13874052', '13744223', '14435520', '12812712', '14559301']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5876859533188086
- 35 USC 102 Novelty (BERT): 0.5050352221859776
- Combined Prediction Score: 0.5794208802055255
- Mean Citation Score: 259.427202
- Max Citation Score: 267.0504
- Similarity Product: 179.78073581929212

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test