PATENT CLAIM ANALYSIS

Application Number: 16000954
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "265100"]

Abstract:
Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula I: These compounds are useful in methods for treating cancer, selectively targeting cancerous cells via the proton coupled folate transporter, folate receptor alpha, and/or folate receptor beta pathways, inhibiting GARFTase in cancerous cells, and selectively targeting activated macrophages in a patient having an autoimmune disease, such as rheumatoid arthritis.

Claim (Index 16):
A compound of Formula II: wherein R 1  is one of a hydrogen (H) or an alkyl group having from 1 to 6 carbon atoms; R 2  is one of (a) a hydrogen (H), (b) a CH 3 , (c) an OH, and (d) NHR wherein R is either a H or an alkyl group having from 1 to 6 carbon atoms; A is one of (a) CR\u2032R\u2033, (b) NR\u2032, wherein R\u2032 and R\u2033 are the same or different and are either a H or an alkyl group having from 1 to 6 carbon atoms, and (c) an oxygen (O); wherein the five membered ring has a side chain attached at position 6, and optionally includes wherein the carbon atom at position 5, has attached thereto either (a) one hydrogen atom, or (b) an alkyl group having from one to six carbon atoms, and R 3  is one of (a) a hydrogen (H), (b) CH 3 , (c) trifluoromethyl, (d) difluoromethyl, (e) monofluoromethyl, (f) methyl ketone, (g) trifluoromethyl ketone, (h) difluoromethyl ketone, (i) monofluoromethyl ketone, (j) formyl, (k) methyl alcohol, (l) methylamine, or (m) a bond; B is one of (a) a sulfur (S) atom, (b) an oxygen (O) atom, or (c) a nitrogen (N) atom; and y is an integer ranging from zero up to and including 7.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 94.0
- Lexical Diversity: 1.44828
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13558873', '15342359', '12242988', '12260502', '15769223']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7828295390740984
- 35 USC 102 Novelty (BERT): 0.599208370819354
- Combined Prediction Score: 0.764467422248624
- Mean Citation Score: 389.297826
- Max Citation Score: 496.8058
- Similarity Product: 471.7113448546888

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test