PATENT CLAIM ANALYSIS

Application Number: 15945630
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-10
Patent Classification: ["424", "400000"]

Abstract:
Methods for targeted delivery of therapeutic agents to a target cell or tissue with lipid nanoparticles comprising ApoE3. In embodiments, the invention specifically relates to targeted delivery of anticancer drugs, antibiotics, antifungal drugs, and diagnostic contrast agents, and associated treatment and diagnostic methods. In embodiments, diseases/conditions treated include those associated with over-expression of LDL receptors.

Claim (Index 5):
A method for enhancing transport of a therapeutic agent across a blood-brain barrier to a target cell or tissue, comprising:\n administering to a subject a lipid nanoparticle loaded with the therapeutic agent, the lipid nanoparticle comprising:\n a lipid core comprised of a triglyceride component and a cholesterol ester component; \n the therapeutic agent; \n a phospholipid layer; \n a surfactant coating layer surrounding the phospholipid layer and the lipid core; and \n human recombinant apolipoprotein (ApoE3) adsorbed to a surface of the nanoparticle without Polysorbate 80,\n wherein: \n the therapeutic agent is transported to the target cell or tissue in a concentration that is at least 10 times greater than a concentration transported by the same lipid nanoparticle without human recombinant ApoE3 adsorbed thereto.

Metadata:
- Claim Count in Document: 48.0
- Percentile: 91.0
- Lexical Diversity: 1.48837
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11648808', '10724833', '11802727', '11802197', '11802198']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7656168329504595
- 35 USC 102 Novelty (BERT): 0.5323154402907789
- Combined Prediction Score: 0.7422866936844914
- Mean Citation Score: 356.06647200000015
- Max Citation Score: 371.93008
- Similarity Product: 259.1506353647804

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test