PATENT CLAIM ANALYSIS

Application Number: 16085035
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["564", "433000"]

Abstract:
The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an amine; and reacting the first compound and the second compound in a reaction mixture, the reaction mixture including a catalyst having at least one group 10 atom, the reaction mixture including a base, the base comprising a carbonate salt, a phosphate salt or an acetate salt, the reaction mixture under conditions effective to couple the first compound to the second compound. The present disclosure further describes a one-pot method for coupling a first compound to a second compound in the presence of a mild base.

Claim (Index 4):
The method of  claim 1  wherein the catalyst is generated in-situ from a palladium precatalyst, the palladium precatalyst is selected from the group consisting of: Palladium(II) acetate, Palladium(II) chloride, Dichlorobis(acetonitrile)palladium(II), Dichlorobis(benzonitrile)palladium(I1), Allylpalladium chloride dimer, Palladium(II) acetylacetonate, Palladium(II) bromideBis(dibenzylideneacetone)palladium(0), Bis(2-methylallyl)palladium chloride dimer, Crotylpalladium chloride dimer, Dichloro(1,5-cyclooctadiene)palladium(II), Dichloro(norbornadiene)palladium(II), Palladium(II) trifluoroacetate, Palladium(II) benzoate, Palladium(II) trimethylacetate, Palladium(II) oxide, Palladium(II) cyanide, Tris(dibenzylideneacetone)dipalladium(0), Palladium(II) hexafluoroacetylacetonate, cis-Di chloro(N,N,N,N\u2032-tetramethylethylenediamine)palladium(II), and Cyclopentadienyl[(1,2,3-n)-1-phenyl-2-propenyl]palladium(II), Allyl(cyclopentadienyl)paladium(II), [1,3-Bis(2,6-Diisopropyphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II)dichloride, and (1,3-Bis(2,6-diisopropylphenyl)imidazolidene) (3-chloropyridyl) palladium(II) dichloride, and a mixture of two or more thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 2.46154
- Patent Class: 564.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15515069', '14733139', '11734593', '13801039', '15529186']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7227726646813207
- 35 USC 102 Novelty (BERT): 0.530549450365705
- Combined Prediction Score: 0.7035503432497592
- Mean Citation Score: 236.966986
- Max Citation Score: 311.42862
- Similarity Product: 310.0447044960523

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test