PATENT CLAIM ANALYSIS

Application Number: 15882929
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-08
Patent Classification: ["424", "773000"]

Abstract:
Cenchrus ciliaris  L. as an anticancer agent was obtained by separately extracting the aerial parts of the plant and the root part of the plants. Extractions were performed first in ethanol, and then a portion successively in water, chloroform, and aqueous butanol. All extracts were tested for cytotoxicity against six cancer cell lines. Generally, the root extracts exhibited greater cytotoxicity than the aerial extracts. The highest anticancer effects for both aerial and root extracts were shown against hepatocellular cancer, colorectal cancer, and lung cancer, compared to the other cell lines tested. The chloroform extracts showed greater anticancer effects, both for aerial and root extracts.

Claim (Index 1):
A method for achieving an effect in a patient, comprising administering an effective amount of an extract of aerial parts of  Cenchrus ciliaris  L. in ethanol to the patient, wherein the effect is death of lung cancer cells or inhibiting the growth of a lung cancer tumor, death of colorectal (CACO) cancer cells or inhibiting the growth of a colorectal (CACO) cancer tumor, death of colon (HCT-116) cancer cells or inhibiting the growth of a colon (HCT-116) cancer tumor, death of cervical cancer cells or inhibiting the growth of a cervical cancer tumor, death of hepatocellular cancer cells or inhibiting the growth of a hepatocellular cancer tumor, or death of breast cancer cells or inhibiting the growth of a breast cancer tumor, wherein the extract of  Cenchrus ciliaris  L. comprises:\n a mixture of lipoidal compounds separated from the ethanol extract by serial extraction in water to form an aqueous extract and filtration of the aqueous extract to remove the lipoidal compounds; wherein the mixture of lipoidal compounds includes fatty acids, chlorophyll, sterols and triterpenes; a mixture of low polarity phenolic compounds separated from the aqueous extract by serial extraction in chloroform after removal of the lipoidal compounds to form a chloroform extract containing the mixture of low polarity phenolic compounds; a mixture of highly polar phenolic and remaining non-phenolic compounds separated from the aqueous extract by serial extraction in n-butanol saturated with water after removal of the lipoidal compounds and low polarity phenolic compounds to form a butanol extract containing the mixture of highly polar phenolic and remaining non-phenolic compounds; and wherein the mixture of highly polar phenolic and remaining non-phenolic compounds includes compounds selected from the group consisting of carbohydrates, glycosides, flavonoids, proteins, amino acids, phenolic compounds and tannins.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 86.0
- Lexical Diversity: 1.87302
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15881653', '15878367', '13701673', '11125782', '10650942']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6839142819444171
- 35 USC 102 Novelty (BERT): 0.4785977873198804
- Combined Prediction Score: 0.6633826324819634
- Mean Citation Score: 132.95641600000002
- Max Citation Score: 144.35567
- Similarity Product: 97.15688668396234

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test