PATENT CLAIM ANALYSIS

Application Number: 15953108
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "279000"]

Abstract:
The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

Claim (Index 22):
The bifunctional compound according to  claim 21 , wherein:\n when R PTM9  is the covalently joined position, R PTM7  and R PTM8  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM7  and R PTM8  are attached; or when R PTM8  is the covalently joined position, R PTM9  and R PTM10  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM9  and R PTM10  are attached; or when RPTM10 is the covalently joined position, RPTM8 and RPTM9 are connected together via a covalent bond in a way to form a bicyclic group with the ring to which RPTM8 and RPTM9 are attached; or when R PTM12  is the covalently joined position, R PTM13  and R PTM14  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM13  and R PTM14  are attached, and/or R PTM15  and R PTM16  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM15  and R PTM16  are attached; or when R PTM13  is the covalently joined position, R PTM12  and R PTM16  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM12  and R PTM16  are attached, and/or R PTM15  and R PTM16  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM15  and R PTM16  are attached; or when R PTM16  is the covalently joined position, R PTM12  and R PTM13  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM12  and R PTM13  are attached, and/or R PTM13  and R PTM14  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM13  and R PTM14  are attached; or when R PTM24  is the covalently joined position, R PTM31  and R PTM32  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM31  and R PTM32  are attached, or R PTM29  and R PTM30  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM29  and R PTM30  are attached; or when R PTM29  is the covalently joined position, R PTM24  and R PTM32  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM24  and R PTM32  are attached, and/or R PTM31  and R PTM32  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM31  and R PTM32  are attached; or when R PTM32  is the covalently joined position, R PTM24  and R PTM29  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM24  and R PTM29  are attached, and/or R PTM29  and R PTM30  are connected together via a covalent bond in a way to form a bicyclic group with the ring to which R PTM29  and R PTM30  are attached.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.675
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15881318', '14822309', '15730728', '16346483', '15148253']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7957342347690003
- 35 USC 102 Novelty (BERT): 0.5587293230930884
- Combined Prediction Score: 0.7720337436014091
- Mean Citation Score: 365.22769200000016
- Max Citation Score: 518.0048
- Similarity Product: 285.4759731878281

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test