PATENT CLAIM ANALYSIS

Application Number: 15979054
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "450000"]

Abstract:
The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a mRNA solution and a lipid solution, wherein the mRNA solution and/or the lipid solution are at a pre-determined temperature greater than ambient temperature.

Claim (Index 54):
A nanoparticle formulation comprising lipid nanoparticles encapsulating mRNA encoding cystic fibrosis conductance regulator protein,\n wherein the mRNA encoding cystic fibrosis conductance regulator protein is encapsulated in the lipid nanoparticles at an encapsulation efficiency of 85% or greater, and wherein the lipid nanoparticles have an average size of 80 nm or less.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 93.0
- Lexical Diversity: 1.57143
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14790562', '15878131', '15809605', '15878137', '15451312']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7622062590272154
- 35 USC 102 Novelty (BERT): 0.5495308358112694
- Combined Prediction Score: 0.7409387167056208
- Mean Citation Score: 321.677014
- Max Citation Score: 360.9262
- Similarity Product: 287.87608207070826

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test