PATENT CLAIM ANALYSIS

Application Number: 16177149
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "300000"]

Abstract:
Diazanaphthalene compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a diazanaphthalene compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Claim (Index 12):
The compound of  claim 1 , wherein the compound of Formula I is selected from the group consisting of:\n N-(2-(1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-isobutylpiperidine-4-carboxamide [1]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)cyclopropanecarboxamide [2]; 4,4-difluoro-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [3]; trans-4-methoxy-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [4]; trans-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-4-morpholinocyclohexane-1-carboxamide [5]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [6]; trans-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-4-((4-methylpiperazin-1-yl) methyl)cyclohexane-1-carboxamide [7]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [8]; (S)-2-(3-fluoropyrrolidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [9]; (S)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)tetrahydrofuran-2-carboxamide [10]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [11]; 1-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [12]; 1-isopropyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [13]; 1-(tert-butyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [14]; 1-cyclopropyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [15]; 1-isobutyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [16]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-neopentylpiperidine-4-carboxamide [17]; 1-(2-fluoroethyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [18]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [19]; 1-butyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [20]; 1-benzoyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [21]; 1-(2,2-difluoropropyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [22]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)azetidine-3-carboxamide [23]; 1-(2,2-difluoroethyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [24]; 1-(2-fluoro-2-methylpropyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [25]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [26]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-((3-methyloxetan-3-yl)methyl) piperidine-4-carboxamide [27]; 1-(2-methoxyethyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [28]; 1-(2-isopropoxyethyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [29]; 1,1-diisobutyl-4-((2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl)piperidin-1-ium [30]; 4-fluoro-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [31]; 4-fluoro-1-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [32]; 4-fluoro-1-isobutyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [33]; (S)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-3-carboxamide [34]; (R)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-3-carboxamide [35]; (S)-1-isobutyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-3-carboxamide [36]; (R)-1-isobutyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-3-carboxamide [37]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)tetrahydro-2H-pyran-4-carboxamide [38]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl)acetamide [39]; 2-(4-fluoropiperidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [40]; trans-4-amino-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [41]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)acetamide [42]; (S)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-2-carboxamide [43]; 2-(4-isobutylpiperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [44]; 2-(3,3-dimethylazetidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [45]; (R)-2-(3-fluoropyrrolidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [46]; (S)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2-methylpyrrolidin-1-yl) acetamide [47]; 2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [48]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [49]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperidin-1-yl)acetamide [50]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-(trifluoromethyl)piperidin-1-yl) acetamide [51]; 2-(4-(difluoromethyl)piperidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [52]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [53]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)propanamide [54]; (R)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2-methylpyrrolidin-1-yl) acetamide [55]; 2-(cyclobutyl(methyl)amino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [56]; 2-(diethylamino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [57]; 7-(2-fluoroethyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-7-azaspiro[3.5]nonane-2-carboxamide [58]; 4-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperazine-1-carboxamide [59]; (S)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)propanamide [60]; (R)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)propanamide [61]; (R)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)pyrrolidine-2-carboxamide [62]; 2-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-azaspiro[3.3]heptane-6-carboxamide [63]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [64]; 2-(2-fluoroethyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-azaspiro[3.3]heptane-6-carboxamide [65]; trans-4-(dimethylamino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [66]; 1-acetyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [67]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-((1-(trifluoromethyl)cyclopropyl) methyl)piperidine-4-carboxamide [68]; (S)-1-(2-fluoropropyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [69]; (R)-1-(2-fluoropropyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [70]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [71]; 1\u2032-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [72]; trans-4-(hydroxymethyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [73]; methyl 2-(4-((2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl)piperidin-1-yl) acetate [74]; 1-benzyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [75]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [76]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [77]; (S)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(3-methylmorpholino)acetamide [78]; (R)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(3-methylmorpholino)acetamide [79]; (S)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2-methylmorpholino)acetamide [80]; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [81]; 2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [82]; 2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [83]; 2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [84]; (S)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-morpholinopropanamide [85]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(morpholin-2-yl)acetamide [86]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylmorpholin-2-yl)acetamide [87]; 2-(4-ethylpiperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [88]; 2-(4-isopropylpiperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [89]; 2-(4-cyclopropylpiperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [90]; 2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [91]; (S)-2-(2,4-dimethylpiperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [92]; 1-(2-hydroxyethyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [93]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxamide [94]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(oxazol-2-ylmethyl)piperidine-4-carboxamide [95]; (R)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-oxotetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxamide [96]; (R)-1-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)pyrrolidine-2-carboxamide [97]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(tetrahydro-2H-pyran-4-yl)piperidine-4-carboxamide [98]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(pyrimidin-2-ylmethyl)piperidine-4-carboxamide [99]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(pyrazin-2-ylmethyl)piperidine-4-carboxamide [100]; 1-((5-methyl-1,2,4-oxadiazol-3-yl)methyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [101]; 1-(2-hydroxy-2-methylpropyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) piperidine-4-carboxamide [102]; tert-butyl 2-(4-((2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl)piperidin-1-yl)acetate [103]; 2-(4-((2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl)piperidin-1-yl)acetic acid [104]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [105]; tert-butyl (2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamate [106]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)but-2-ynamide [107]; trans-4-((2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl)cyclohexane-1-carboxylic acid [108]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-morpholinopropanamide [109]; trans-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-morphrpolinocyclobutane-1-carboxamide [110]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)quinuclidine-4-carboxamide [111]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl)propanamide [112]; 1-isobutyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)azepane-4-carboxamide [113]; 2-(4-methoxypiperidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [114]; 2-(4-hydroxypiperidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [115]; 3-(hydroxymethyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)bicyclo[1.1.1]pentane-1-carboxamide [116]; 1-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)azepane-4-carboxamide [117]; trans-4-(dimethylamino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [118]; trans-4-(bis(methyl-d 3 )amino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [119]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-((4-methylpiperazin-1-yl)methyl) bicyclo[1.1.1]pentane-1-carboxamide [120]; methyl trans-4-((2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl)cyclohexane-1-carboxylate [121]; 2-(1-isobutylpyrrolidin-3-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [122]; trans-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-4-(4-methylpiperazine-1-carbonyl)cyclohexane-1-carboxamide [123]; 1-isobutyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [124]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(phenylsulfonyl)piperidine-4-carboxamide [125]; 8-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3,8-diazabicyclo[3.2.1]octane-3-carboxamide [126]; 3-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxamide [127]; (1R,3s,5S)-3-amino-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [128]; (1R,3s,5S)\u2014N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-((3,3,3-trifluoropropyl) amino)-8-azabicyclo[3.2.1]octane-8-carboxamide [129]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [130]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)morpholine-4-carboxamide [131]; 4-(dimethylamino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [132]; (S)-2,4-dimethyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperazine-1-carboxamide [133]; 1-methyl-3-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)urea [134]; 1-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(1-methylpiperidin-4-yl)urea [135]; 4-isopropyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperazine-1-carboxamide [136]; (R)-3,4-dimethyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperazine-1-carboxamide [137]; N-(2-(1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [138]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(piperazin-1-yl)benzamide [139]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(4-methylpiperazin-1-yl)benzamide [140]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(pyrrolidin-1-ylmethyl)benzamide [141]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(piperidin-4-yloxy)benzamide [142]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-((1-methylpiperidin-4-yl)oxy) benzamide [143]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [144]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-4-((1-methylpiperidin-4-yl)oxy) benzamide [145]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperazin-1-yl)isonicotinamide [146]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [147]; 2-(4-isopropylpiperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [148]; 2-(4-cyclopropylpiperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [149]; 2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [150]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [151]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-5-(piperidin-4-yloxy)nicotinamide [152]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-yloxy)isonicotinamide [153]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-((1-methylpiperidin-4-yl)oxy) isonicotinamide [154]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-5-(piperidin-4-ylamino)nicotinamide [155]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-5-((1-methylpiperidin-4-yl)amino) nicotinamide [156]; 2-(4-aminopiperidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [157]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-(methylamino)piperidin-1-yl) isonicotinamide [158]; 2-(4-(dimethylamino)piperidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [159]; 2-((1-isopropylpiperidin-4-yl)oxy)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [160]; 2-(3-aminoazetidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [161]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [162]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-morpholinoisonicotinamide [163]; 2-((2-(dimethylamino)ethyl)amino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [164]; 2-(2-(dimethylamino)ethoxy)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [165]; 2-(4-isobutylpiperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [166]; 2-(azetidin-3-yloxy)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [167]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-((1-methylazetidin-3-yl)oxy) isonicotinamide [168]; 2-(4-ethylpiperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [169]; 4-((dimethylamino)methyl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzamide [170]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(1-methylpiperidin-4-yl)benzamide [171]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-((4-methylpiperazin-1-yl)methyl) benzamide [172]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [173]; 2-hydroxy-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [174]; 2-isopropoxy-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [175]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(1-methylpiperidin-4-yl) isonicotinamide [176]; 1\u2032-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [177]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-(6-(4-methylpiperazin-1-yl) nicotinoyl)piperazin-1-yl)isonicotinamide [178]; 2-(4-hydroxy-4-methyl-4\u03bb 4 -piperazin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [179]; 2-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-6-(4-methylpiperazin-1-yl) isonicotinamide [180]; 3-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [181]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [182]; 2-((2S,6R)-2,6-dimethylmorpholino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [183]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [184]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [185]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl) isonicotinamide [186]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide [187]; 2-(methyl(1-methylpiperidin-4-yl)amino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [188]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-((1-methylpiperidin-4-yl)thio) isonicotinamide [189]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)pyrimidine-4-carboxamide [190]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-6-(4-methylpiperazin-1-yl)pyridazine-4-carboxamide [191]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-6-(4-methylpiperazin-1-yl)pyrimidine-4-carboxamide [192]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-phenylacetamide [193]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-phenylpropanamide [194]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyridin-3-yl)acetamide [195]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(pyridin-3-yl)propanamide [196]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyridin-4-yl)acetamide [197]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(pyridin-4-yl)propanamide [198]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)isoindoline-5-carboxamide [199]; 2-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)isoindoline-5-carboxamide [200]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [201]; 2-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [202]; 2-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide [203]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide [204]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-indole-5-carboxamide [205]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzofuran-5-carboxamide [206]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)furo[2,3-c]pyridine-5-carboxamide [207]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzo[b]thiophene-5-carboxamide [208]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzofuran-6-carboxamide [209]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzo[d]oxazole-6-carboxamide [210]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzo[d]thiazole-6-carboxamide [211]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzo[d]oxazole-5-carboxamide [212]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzo[d]thiazole-5-carboxamide [213]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)quinoline-3-carboxamide [214]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)quinoline-6-carboxamide [215]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)quinoxaline-6-carboxamide [216]; 5-chloro-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [217]; 3-chloro-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [218]; 2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [219]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)isonicotinamide [220]; 3-fluoro-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [221]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-((4-methylpiperazin-1-yl)methyl) isonicotinamide [222]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(morpholinomethyl)isonicotinamide [223]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-ylmethyl) isonicotinamide [224]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetamide [225]; 1-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-indazole-5-carboxamide [226]; 1-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-benzo[d]imidazole-5-carboxamide [227]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(piperidin-4-yl)-1H-pyrazole-4-carboxamide [228]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [229]; 1-(1-ethylpiperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [230]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [231]; 1-(1-isopropylpiperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [232]; 1-(1-cyclopropylpiperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [233]; isopropyl 4-(4-((2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate [234]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [235]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [236]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-1,2,3-triazole-4-carboxamide [237]; 1-(1-isopropylpiperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-1,2,3-triazole-4-carboxamide [238]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)oxazole-5-carboxamide [239]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) oxazole-4-carboxamide [240]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [241]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [242]; 2-(1-(2-fluoroethyl)piperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) oxazole-4-carboxamide [243]; 2-(1-isopropylpiperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)oxazole-4-carboxamide [244]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)oxazole-4-carboxamide [245]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) thiazole-5-carboxamide [246]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-yl)thiazole-4-carboxamide [247]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)thiazole-4-carboxamide [248]; 2-(1-(2-fluoroethyl)piperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) thiazole-4-carboxamide [249]; 2-(1-isopropylpiperidin-4-yl)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)thiazole-4-carboxamide [250]; 1-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl-8-d)piperidine-4-carboxamide [251]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(2-(methyl-d 3 )propyl-1,1,2,3,3,3-d 6 ) piperidine-4-carboxamide [252]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d 4 )acetamide [253]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-(methyl-d 3 )piperazin-1-yl) acetamide [254]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(morpholino-d 8 )acetamide [255]; (S)\u2014N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)propanamide [256]; 1-isobutyl-N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [257]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) acetamide [258]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [259]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl)acetamide [260]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [261]; N-(2-(1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-(methyl-d 3 )piperazin-1-yl)isonicotinamide [262]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-(methyl-d 3 )piperazin-1-yl) isonicotinamide [263]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [264]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-(methyl-d 3 )piperazin-1-yl) isonicotinamide [265]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(piperidin-4-yl)-1H-pyrazole-4-carboxamide [266]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [267]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [268]; N-(2-(1-(methyl-d 3 )-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [269]; N-(2-(1-ethyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [270]; N-(2-(1-cyclopropyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [271]; N-(2-(1-cyclopropyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [272]; N-(2-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) cyclohexanecarboxamide [273]; 2-(pyrrolidin-1-yl)-N-(2-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [274]; N-(2-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [275]; N-(2-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)tetrahydro-2H-pyran-4-carboxamide [276]; N-(2-(5-(azetidin-1-ylmethyl)-1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-4,4-difluorocyclohexane-1-carboxamide [277]; 4,4-difluoro-N-(2-(1-methyl-5-(pyrrolidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [278]; 4,4-difluoro-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [279]; 2-(2-fluoroethyl)-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-azaspiro[3.3]heptane-6-carboxamide [280]; tert-butyl 6-((2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl)-2-azaspiro[3.3]heptane-2-carboxylate [281]; 2-fluoro-2-methyl-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)propanamide [282]; 2-(diethylamino)-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)acetamide [283]; trans-4-methoxy-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [284]; trans-4-(hydroxymethyl)-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [285]; (R)\u2014N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)pyrrolidine-2-carboxamide [286]; 1-isobutyl-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) piperidine-4-carboxamide [287]; N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [288]; 1-benzoyl-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) piperidine-4-carboxamide [289]; N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)tetrahydro-2H-pyran-4-carboxamide [290]; N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperidin-1-yl)acetamide [291]; N-(2-(1-(difluoromethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [292]; N-(2-(1-ethyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [293]; N-(2-(1-isopropyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(piperidin-4-yloxy)benzamide [294]; N-(2-(1-isopropyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-((1-methylpiperidin-4-yl)oxy) benzamide [295]; N-(2-(1-isopropyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [296]; N-(2-(1-cyclopropyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [297]; 4-fluoro-N-(2-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzamide [298]; 4-(difluoromethoxy)-N-(2-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) benzamide [299]; 5-fluoro-N-(2-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)nicotinamide [300]; N 2 -methyl-N 5 -(2-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)pyridine-2,5-dicarboxamide [301]; 1-isopropyl-N-(2-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [302]; 2-methyl-N-(2-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)thiazole-5-carboxamide [303]; N-(2-(5-amino-1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [304]; 4-(difluoromethoxy)-N-(2-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) benzamide [305]; N-(2-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [306]; N-(2-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [307]; 4-fluoro-N-(2-(1-methyl-5-(pyrrolidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) benzamide [308]; 4-fluoro-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) benzamide [309]; 4-(difluoromethoxy)-N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)benzamide [310]; N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-3-(pyrrolidin-1-ylmethyl)benzamide [311]; N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [312]; N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-morpholinoisonicotinamide [313]; N-(2-(1-methyl-5-(morpholinomethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-morpholinoisonicotinamide [314]; N-(2-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [315]; 3,3-difluoro-N-(2-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)cyclobutane-1-carboxamide [316]; N-((4,4-difluorocyclohexyl)methyl)-2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-amine [317]; N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [318]; N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [319]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)acetamide [320]; (R)\u2014N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-1-isobutylpiperidine-3-carboxamide [321]; N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl) piperidine-4-carboxamide [322]; 4-fluoro-N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-1-isobutylpiperidine-4-carboxamide [323]; N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)acetamide [324]; 4-fluoro-N-(2-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)benzamide [325]; N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-3-(4-methylpiperazin-1-yl)benzamide [326]; N 5 -(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-N 2 -methylpyridine-2,5-dicarboxamide [327]; N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [328]; 2-(azetidin-3-yloxy)-N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)isonicotinamide [329]; N-(2-(1-methyl-1H-pyrazol-5-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [330]; 1-methyl-N-(2-(1-methyl-1H-pyrazol-3-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [331]; N-(2-(1-methyl-1H-pyrazol-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [332]; 2-fluoro-2-methyl-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)propanamide [333]; 2,2,3,3-tetramethyl-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)cyclopropane-1-carboxamide [334]; trans-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-4-(pyrrolidin-1-yl) cyclohexane-1-carboxamide [335]; trans-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-4-morpholinocyclohexane-1-carboxamide [336]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl)acetamide [337]; 1-ethyl-4-fluoro-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [338]; 4-fluoro-1-isobutyl-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [339]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [340]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)cyclopropanecarboxamide [341]; 4,4-difluoro-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [342]; trans-4-(dimethylamino)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [343]; trans-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-4-((4-methylpiperazin-1-yl) methyl)cyclohexane-1-carboxamide [344]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [345]; 1-isobutyl-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [346]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1-((1-(trifluoromethyl)cyclopropyl) methyl)piperidine-4-carboxamide [347]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1-((3-methyloxetan-3-yl)methyl) piperidine-4-carboxamide [348]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1-(2-(pyrrolidin-1-yl)acetyl) piperidine-4-carboxamide [349]; 1\u2032-methyl-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [350]; (R)\u2014N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-3-carboxamide [351]; (R)-1-isobutyl-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)piperidine-3-carboxamide [352]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [353]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) acetamide [354]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [355]; 1-(2-hydroxy-2-methylpropyl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl) piperidine-4-carboxamide [356]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [357]; 2-(4-methoxypiperidin-1-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl) acetamide [358]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)morpholine-4-carboxamide [359]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1-(piperidin-4-yl)-1H-pyrazole-4-carboxamide [360]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [361]; 1-(1-ethylpiperidin-4-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [362]; 1-(1-isopropylpiperidin-4-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [363]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [364]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1H-1,2,3-triazole-4-carboxamide [365]; 1-(1-isopropylpiperidin-4-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1H-1,2,3-triazole-4-carboxamide [366]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [367]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [368]; 2-(1-isopropylpiperidin-4-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl) oxazole-4-carboxamide [369]; 2-fluoro-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)benzamide [370]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-3-((1-methylpiperidin-4-yl)oxy) benzamide [371]; N 2 -methyl-N 5 -(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)pyridine-2,5-dicarboxamide [372]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-6-(4-methylpiperazin-1-yl) nicotinamide [373]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [374]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(1-methylpiperidin-4-yl) isonicotinamide [375]; 2-(4-(dimethylamino)piperidin-1-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [376]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-morpholinoisonicotinamide [377]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [378]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [379]; 2-(4-isopropylpiperazin-1-yl)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl) isonicotinamide [380]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-ylamino) isonicotinamide [381]; 2-(methyl(1-methylpiperidin-4-yl)amino)-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [382]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-((1-methylpiperidin-4-yl)thio) isonicotinamide [383]; 2-methyl-N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide [384]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(piperazin-1-yl)isonicotinamide [385]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2-(4-methylpiperazin-1-yl) pyridin-4-yl)acetamide [386]; 1,1-bis(methyl-d 3 )-4-(4-((2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl) pyridin-2-yl)piperazin-1-ium [387]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-(methyl-d3)piperazin-1-yl) isonicotinamide [388]; N-(2-(1-methyl-1H-1,2,3-triazol-5-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [389]; N-(2-(4-methyl-4H-1,2,4-triazol-3-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [390]; N-(2-(4-methyl-4H-1,2,4-triazol-3-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [391]; 4-fluoro-1-isobutyl-N-(2-(4-methyl-4H-1,2,4-triazol-3-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [392]; N-(2-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [393]; N-(2-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl) piperidine-4-carboxamide [394]; N-(2-(1H-1,2,3-triazol-1-yl)-1,6-naphthyridin-7-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [395]; N-(2-(2H-1,2,3-triazol-2-yl)-1,6-naphthyridin-7-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [396]; N-(2-(1H-1,2,4-triazol-1-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [397]; 1-isobutyl-N-(2-(1-methyl-1H-tetrazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [398]; 2,2,3,3-tetramethyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)cyclopropane-1-carboxamide [399]; 4,4-difluoro-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [400]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl)acetamide [401]; 2-fluoro-2-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)propanamide [402]; 1-fluoro-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)cyclopropane-1-carboxamide [403]; 2-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-azaspiro[3.3]heptane-6-carboxamide [404]; 1-fluoro-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [405]; trans-4-methoxy-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [406]; trans-4-(hydroxymethyl)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [407]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)azetidine-3-carboxamide [408]; (R)\u2014N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)tetrahydrofuran-2-carboxamide [409]; 1-(2-methoxyethyl)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [410]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [411]; 1-isobutyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [412]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [413]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)propanamide [414]; 2-isopropoxy-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [415]; 3-isopropoxy-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)propanamide [416]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)cyclopropanecarboxamide [417]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexanecarboxamide [418]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4,4-difluorocyclohexane-1-carboxamide [419]; (S)\u2014N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)tetrahydrofuran-2-carboxamide [420]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-3,3-difluorocyclobutane-1-carboxamide [421]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1-fluorocyclopropane-1-carboxamide [422]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)morpholine-4-carboxamide [423]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)morpholine-d 8 -4-carboxamide [424]; 1-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [425]; 1-ethyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [426]; 1-isopropyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [427]; 1-cyclopropyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [428]; 1-isobutyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [429]; 1-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-3-carboxamide [430]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(1-methyl-1H-pyrazol-4-yl) acetamide [431]; 1-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-imidazole-4-carboxamide [432]; 1-isopropyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-imidazole-4-carboxamide [433]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazole-4-carboxamide [434]; 1,2-dimethyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-imidazole-5-carboxamide [435]; 1-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-1,2,4-triazole-3-carboxamide [436]; 2-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)oxazole-4-carboxamide [437]; 2-isopropyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)oxazole-4-carboxamide [438]; 4-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)oxazole-2-carboxamide [439]; 4-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)thiazole-2-carboxamide [440]; 2-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)thiazole-4-carboxamide [441]; 5-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1,3,4-oxadiazole-2-carboxamide [442]; 5-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1,3,4-thiadiazole-2-carboxamide [443]; 1-isopropyl-N-(2-(1-isopropyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [444]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1-methyl-1H-pyrazole-4-carboxamide [445]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-1-isopropyl-1H-pyrazole-4-carboxamide [446]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-methylthiazole-5-carboxamide [447]; 4-fluoro-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide [448]; 4-(difluoromethoxy)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide [449]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-3-(pyrrolidin-1-ylmethyl)benzamide [450]; 2-fluoro-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-3,4,5,6-d 4  [451]; 4-fluoro-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-2,3,5,6-d 4  [452]; 2-chloro-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-3,4,5,6-d 4  [453]; 4-chloro-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-2,3,5,6-d 4  [454]; 4-(methyl-d 3 )-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide [455]; 4-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-2,3,5,6-d 4  [456]; 4-(methyl-d 3 )-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-2,3,5,6-d 4  [257]; 4-(methoxy-d 3 )-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide [458]; 4-(methoxy-d 3 )-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-2,3,5,6-d 4  [459]; 4-methoxy-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-2,3,5,6-d 4  [460]; (E)-N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-3-(phenyl-2,3,4,5,6-d 5 ) acrylamide [461]; (E)-N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-3-(phenyl-2,3,4,5,6-d 5 ) acrylamide-2,3-d 2  [462]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-fluorophenyl)acetamide-2,2-d 2  [463]; (E)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide [464]; (E)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide-2,3-d 2  [465]; 2-(4-fluorophenyl)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)acetamide-2,2-d 2  [466]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [467]; 2-(dimethylamino)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [468]; 2-(3-aminoazetidin-1-yl)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [469]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)isonicotinamide [470]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl)isonicotinamide [471]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-morpholinoisonicotinamide [472]; 2-(4-isopropylpiperazin-1-yl)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [473]; 2-(4-cyclopropylpiperazin-1-yl)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [474]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [475]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [476]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)isoindoline-5-carboxamide [477]; 2-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)isoindoline-5-carboxamide [478]; 2-(azetidin-1-yl)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [479]; 2-methoxy-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [480]; 2-methyl-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [481]; 2-cyano-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [482]; 2-(3,3-difluoroazetidin-1-yl)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [483]; 2-(4,4-difluoropiperidin-1-yl)-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [484]; 2-isopropoxy-N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [485]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d 4 ) isonicotinamide [486]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl-d 8 )isonicotinamide [487]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl-d 10 )isonicotinamide [488]; N-(2-(1-methyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(morpholino-d)isonicotinamide [489]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4-isopropoxybenzamide [490]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [491]; 4-(benzyloxy)-N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide [492]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-fluorobenzamide-3,4,5,6-d 4  [493]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4-fluorobenzamide-2,3,5,6-d 4  [494]; 2-chloro-N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-3,4,5,6-d 4  [495]; 4-chloro-N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)benzamide-2,3,5,6-d 4  [496]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4-(methyl-d 3 )benzamide [497]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4-methylbenzamide-2,3,5,6-d 4  [498]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4-(methyl-d 3 )benzamide-2,3,5,6-d 4  [499]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4-(methoxy-d 3 )benzamide [500]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4-(methoxy-d 3 )benzamide-2,3,5,6-d 4  [501]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-4-methoxybenzamide-2,3,5,6-d 4  [502]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [503]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-6-naphthyridin-7-yl)-2-morpholinoisonicotinamide [504]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)isonicotinamide [505]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(dimethylamino)isonicotinamide [506]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d 4 ) isonicotinamide [507]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl-d 8 ) isonicotinamide [508]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl-d 10 ) isonicotinamide [509]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(morpholino-d 8 )isonicotinamide [510]; N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl) cyclopropanecarboxamide [511]; N-(2-(7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl) cyclopropanecarboxamide [512]; 3,3-difluoro-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl) cyclobutane-1-carboxamide [513]; (R)\u2014N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)pyrrolidine-2-carboxamide [514]; (R)\u2014N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)piperidine-3-carboxamide [515]; 1-methyl-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [516]; N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [517]; 1-benzoyl-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [518]; 4-fluoro-1-isobutyl-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl) piperidine-4-carboxamide [519]; (R)-2-(2-methylpyrrolidin-1-yl)-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)acetamide [520]; 2-(cyclobutyl(methyl)amino)-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)acetamide [521]; 4-fluoro-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)benzamide [522]; 4-isopropoxy-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl) benzamide [523]; 4-(difluoromethoxy)-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl) benzamide [524]; 2-((2-(dimethylamino)ethyl)amino)-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)isonicotinamide [525]; 2-((1-isopropylpiperidin-4-yl)oxy)-N-(2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)isonicotinamide [526]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [527]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)cyclopropanecarboxamide [528]; (R)\u2014N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)tetrahydrofuran-2-carboxamide [529]; (R)\u2014N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-3-carboxamide [530]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)tetrahydro-2H-pyran-4-carboxamide [531]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [532]; 1\u2032-methyl-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [533]; cis-4-morpholino-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexexane-1-carboxamide [534]; 2-(cyclobutyl(methyl)amino)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [535]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [536]; (R)-2-(2-methylpyrrolidin-1-yl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [537]; 2-(4-methylpiperazin-1-yl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [538]; trans-4-((4-methylpiperazin-1-yl)methyl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [539]; 1-(2,2-difluoropropyl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [540]; trans-4-(hydroxymethyl)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [541]; trans-4-(methylamino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [542]; trans-4-((1,3-difluoropropan-2-yl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [543]; trans-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-4-((propan-2-yl-1,1,1,3,3,3-d 6 )amino) cyclohexane-1-carboxamide [544]; trans-4-((2,2-difluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [545]; trans-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-4-((3,3,3-trifluoropropyl)amino) cyclohexane-1-carboxamide [546]; trans-4-((2-methoxyethyl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [547]; trans-4-(dimethylamino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [548]; trans-4-(bis(methyl-d 3 )amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [549]; cis-4-(dimethylamino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [550]; trans-4-((2,2-difluoroethyl)(methyl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [551]; trans-4-(methyl(oxetan-3-yl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [552]; trans-4-((2-fluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [553]; trans-4-(2-(fluoromethyl)aziridin-1-yl)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [554]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [555]; trans-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-3-morpholinocyclobutane-1-carboxamide [556]; trans-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-4-morpholinocyclohexane-1-carboxamide [557]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl)acetamide [558]; 2-(4-methoxypiperidin-1-yl)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [559]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)acetamide [560]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)morpholine-4-carboxamide [561]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [562]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-3-morpholinopropanamide [563]; 1-methyl-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [564]; 1-(2,2-difluoropropyl)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [565]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-4-morpholinopiperidine-1-carboxamide [566]; 4-((1,3-difluoropropan-2-yl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [567]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [568]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [569]; 4-(dimethylamino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [570]; 4-((2,2-difluoroethyl)(methyl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [571]; (3S,4S)-4-amino-3-fluoro-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [572]; (3S,4S)-3-fluoro-4-(methylamino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [573]; (3R,4R)-4-amino-3-fluoro-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [574]; (3R,4R)-3-fluoro-4-(methylamino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [575]; 4-((2-fluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [576]; 4-((2,2-difluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [577]; (1R,3s,5S)-3-amino-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [578]; (1R,3r,5S)-3-amino-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [579]; (1R,3r,5S)-3-((2-fluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [580]; (1R,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [581]; (1R,3s,5S)\u2014N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-3-((3,3,3-trifluoropropyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxamide [582]; (3S,4S)-3-fluoro-4-(isopropylamino)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [583]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [584]; 2-methyl-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [585]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-2-(morpholino-d 8 )acetamide [586]; trans-N-(2-(2-methyloxazol-4-yl)-1,6-naphthyridin-7-yl)-4-(4-methylpiperazin-1-yl)cyclohexane-1-carboxamide [587]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [588]; 2-(1H-imidazol-1-yl)-N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [589]; 4-(difluoromethoxy)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)benzamide [590]; 3-((1-methylpiperidin-4-yl)oxy)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)benzamide [591]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [592]; 2-(3-aminoazetidin-1-yl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [593]; 2-(1-methylpiperidin-4-yl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [594]; 1\u2032-methyl-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [595]; 2-(4-methylpiperazin-1-yl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [596]; 2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [597]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide [598]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-ylamino)isonicotinamide [599]; 2-methyl-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)isoindoline-5-carboxamide [600]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [601]; N-(2-(2-methyloxazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [602]; N-(2-(3-methylisoxazol-5-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [603]; 4-fluoro-1-isobutyl-N-(2-(5-methyl-1,3,4-oxadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [604]; 1-isobutyl-N-(2-(5-methyl-1,3,4-oxadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [605]; N-(2-(5-(dimethylamino)-1,3,4-oxadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [606]; N-(2-(5-(dimethylamino)-1,3,4-oxadiazol-2-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [607]; N-(2-(5-methyl-1,3,4-oxadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [608]; 3,3-difluoro-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)cyclobutane-1-carboxamide [609]; 2-methyl-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)-2-azaspiro[3.3]heptane-6-carboxamide [610]; 1-fluoro-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [611]; trans-4-(dimethylamino)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [612]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [613]; N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)azetidine-3-carboxamide [614]; 1-methyl-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [615]; 1-(2,2-difluoropropyl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [616]; 1-(oxetan-3-yl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [617]; 1-(2-(pyrrolidin-1-yl)acetyl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [618]; 1\u2032-methyl-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [619]; 2-(pyrrolidin-1-yl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)propanamide [620]; 2-(piperidin-1-yl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [621]; 2-(4-methylpiperazin-1-yl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [622]; 2-morpholino-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [623]; 4-(piperidin-4-yloxy)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)benzamide [624]; N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [625]; 6-(4-methylpiperazin-1-yl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)nicotinamide [626]; 1\u2032-methyl-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [627]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [628]; 2-(4-(dimethylamino)piperidin-1-yl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [629]; 2-(4-methylpiperazin-1-yl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [630]; 2-((1-methylpiperidin-4-yl)thio)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [631]; N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [632]; trans-4-((1,3-difluoropropan-2-yl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [633]; N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)morpholine-4-carboxamide [634]; N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [635]; 2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [636]; N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [637]; N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)-2-(morpholino-d 8 )acetamide [638]; 2-(4-methylpiperazin-1-yl)-N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [639]; 1-methyl-N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [640]; N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [641]; N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)nicotinamide [642]; 2-(4-methylpiperazin-1-yl)-N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [643]; trans-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-morpholinocyclohexane-1-carboxamide [644]; trans-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-(4-methylpiperazin-1-yl) cyclohexane-1-carboxamide [645]; 4-isopropyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperazine-1-carboxamide [646]; 4-((2-methoxyethyl)(methyl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [647]; 4-((1,3-difluoropropan-2-yl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [648]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-((3,3,3-trifluoropropyl)amino) piperidine-1-carboxamide [649]; 4-((2-fluoroethyl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [650]; (3R,4S)-4-amino-3-fluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [651]; (3R,4R)-4-amino-3-fluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [652]; (3S,4S)-3-fluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-(methylamino) piperidine-1-carboxamide [653]; (3R,4R)-3-fluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-(methylamino) piperidine-1-carboxamide [654]; 4-amino-3,3-difluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [655]; (3R,4R)-3-fluoro-4-(isopropylamino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [656]; (3R,4S)-3-fluoro-4-(isopropylamino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [657]; 3,3-difluoro-4-(isopropylamino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [658]; (3S,4S)-3-fluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-((propan-2-yl-1,1,1,3,3,3-d 6 )amino)piperidine-1-carboxamide [659]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [660]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [661]; 4-(dimethylamino)-N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [662]; 4-((2,2-difluoroethyl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [663]; 4-((2,2-difluoroethyl)(methyl-d 3 )amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [664]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-morpholinopiperidine-1-carboxamide [665]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-(4-methylpiperazin-1-yl) piperidine-1-carboxamide [666]; (R)-3,4-dimethyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperazine-1-carboxamide [667]; (S)-3,4-dimethyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperazine-1-carboxamide [668]; (1R,3r,5S)-3-((2-fluoroethyl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [669]; (1R,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [670]; (1R,3r,5S)-3-amino-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [671]; (1S,4S)-5-methyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxamide [672]; (1R,4R)-5-methyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxamide [673]; 8-methyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-3,8-diazabicyclo[3.2.1]octane-3-carboxamide [674]; 3-methyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxamide [675]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [676]; 2-(4-methylpiperazin-1-yl)-N-(2-(5-methylthiazol-2-yl)-1,6-naphthyridin-7-yl)isonicotinamide [677]; 2-(4-methylpiperazin-1-yl)-N-(2-(4-methylthiazol-2-yl)-1,6-naphthyridin-7-yl)isonicotinamide [678]; N-(2-(2-(methylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [679]; 1-methyl-N-(2-(2-(methylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [680]; N-(2-(2-(diethylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-fluoropiperidin-1-yl)acetamide [681]; N-(2-(2-(diethylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)acetamide [682]; N-(2-(2-aminothiazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [683]; N-(2-(2-(methylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [684]; N-(2-(2-(dimethylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [685]; 2-(4-isopropylpiperazin-1-yl)-N-(2-(2-(methylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [686]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(2-(2-(methylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [687]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(2-(2-(dimethylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [688]; 2-(3-aminoazetidin-1-yl)-N-(2-(2-(dimethylamino)thiazol-5-yl)-1,6-naphthyridin-7-yl) isonicotinamide [689]; N-(2-(5-chlorothiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [690]; 2-(7-(2-(4-methylpiperazin-1-yl)isonicotinamido)-1,6-naphthyridin-2-yl)thiazole-5-carboxamide [691]; N-(2-(isothiazol-4-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [692]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-(difluoromethoxy)benzamide [693]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [694]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-((1-methylpiperidin-4-yl)oxy)benzamide [695]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [696]; N 5 -(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-N 2 -methylpyridine-2,5-dicarboxamide [697]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [698]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-1\u2032-methyl-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [699]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(3-(dimethylamino)azetidin-1-yl) isonicotinamide [700]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [701]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(4-isopropylpiperazin-1-yl)isonicotinamide [702]; N-(2-(1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-morpholinoisonicotinamide [703]; 1-fluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [704]; trans-4-methoxy-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [705]; cis-4-methoxy-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [706]; trans-4-amino-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [707]; trans-4-(dimethylamino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [708]; trans-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-morpholinocyclohexane-1-carboxamide [709]; trans-4-(hydroxymethyl)-N-(2-(5-methyl-1,34-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [710]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [711]; 4-fluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [712]; 1-methyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [713]; 4-fluoro-1-methyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [714]; 1-(2-fluoroethyl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [715]; 1-(2,2-difluoroethyl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [716]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [717]; 1-(2,2-difluoropropyl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [718]; 1-benzoyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [719]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [720]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl)acetamide [721]; 2-(4-methoxypiperidin-1-yl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) acetamide [722]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) acetamide [723]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [724]; (R)\u2014N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(3-methylmorpholino)acetamide [725]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) acetamide [726]; 2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)acetamide [727]; 2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)acetamide [728]; 2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)acetamide [729]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(1,4-oxazepan-4-yl)acetamide [730]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide-2,2-d 2  [731]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(morpholino-d 8 )acetamide [732]; 1-methyl-3-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)urea [733]; (3S,4S)-4-amino-3-fluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) piperidine-1-carboxamide [734]; (3S,4S)-4-(dimethylamino)-3-fluoro-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [735]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)morpholine-4-carboxamide [736]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-4-(methylamino)piperidine-1-carboxamide [737]; 4-(dimethylamino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [738]; 4-((2,2-difluoroethyl)(methyl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [739]; (3S,4S)-3-fluoro-4-(isopropylamino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [740]; 2-methyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [741]; 4-methyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)piperazine-1-carboxamide [742]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [743]; 1-(1-isopropylpiperidin-4-yl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [744]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [745]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [746]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [747]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl) isonicotinamide [748]; 1\u2032-methyl-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [749]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [750]; 2-(methyl(1-methylpiperidin-4-yl)amino)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)isonicotinamide [751]; 2-(azetidin-3-yloxy)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)isonicotinamide [752]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-3-((1-methylpiperidin-4-yl)oxy) benzamide [753]; N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-((1-methylpiperidin-4-yl)thio) isonicotinamide [754]; 6-(4-methylpiperazin-1-yl)-N-(2-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)nicotinamide [755]; 2-(4-methylpiperazin-1-yl)-N-(2-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)isonicotinamide [756]; N-(2-(5-amino-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [757]; N-(2-(5-(dimethylamino)-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [758]; N-(2-(3-amino-5-fluorophenyl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [759]; N-(2-(3-fluoro-5-(isopropylamino)phenyl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [760]; 1-methyl-N-(2-(pyridin-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [761]; 2-(4-methylpiperazin-1-yl)-N-(2-(pyridin-2-yl)-1,6-naphthyridin-7-yl)isonicotinamide [762]; 2-(4-methylpiperazin-1-yl)-N-(2-(pyridin-4-yl)-1,6-naphthyridin-7-yl)isonicotinamide [763]; N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)cyclopropanecarboxamide [764]; N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [765]; 1-methyl-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [766]; N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)quinuclidine-4-carboxamide [767]; 2-morpholino-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)acetamide [768]; 2-(morpholino-d 8 )-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)acetamide [769]; 2-(4-methylpiperazin-1-yl)-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)acetamide [770]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)acetamide [771]; 2-(4-methylpiperazin-1-yl)-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)isonicotinamide [772]; 2-(2-methyl-1H-imidazol-1-yl)-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)acetamide [773]; 2-(1H-imidazol-1-yl)-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)acetamide [774]; 2-(piperidin-4-yl)-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)oxazole-4-carboxamide [775]; 2-(1-methylpiperidin-4-yl)-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)oxazole-4-carboxamide [776]; 2-(1-isopropylpiperidin-4-yl)-N-(2-(pyridin-3-yl)-1,6-naphthyridin-7-yl)oxazole-4-carboxamide [777]; trans-N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-3-morpholinocyclobutane-1-carboxamide [778]; trans-N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [779]; N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [780]; N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [781]; N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)acetamide [782]; N-(2-(6-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)acetamide [783]; N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [784]; N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-3-morpholinopropanamide [785]; N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [786]; N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [787]; N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [788]; N-(2-(5-fluoropyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(1-isopropylpiperidin-4-yl)oxazole-4-carboxamide [789]; N-(2-(5-chloropyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [790]; N-(2-(5-methylpyridin-3-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [791]; N-(2-(5-(difluoromethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl)-3-(piperidin-4-yl)benzamide [792]; N-(2-(5-(difluoromethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl)-3-(1-methylpiperidin-4-yl) benzamide [793]; N-(2-(5-(difluoromethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [794]; 2-(4-methylpiperazin-1-yl)-N-(2-(5-(trifluoromethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl) acetamide [795]; 2-(4-methylpiperazin-1-yl)-N-(2-(6-(trifluoromethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl) acetamide [796]; N-(2-(5-(hydroxymethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [797]; N-(2-(5-cyanopyridin-3-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [798]; N-(2-(5-methoxypyridin-3-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [799]; N-(2-(5-methoxypyridin-3-yl)-1,6-naphthyridin-7-yl)-2-morpholinoacetamide [800]; N-(2-(5-methoxypyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [801]; 4-fluoro-N-(2-(5-(piperidin-4-yloxy)pyridin-3-yl)-1,6-naphthyridin-7-yl)benzamide [802]; N-(2-(5-aminopyridin-3-yl)-1,6-naphthyridin-7-yl)-4-fluorobenzamide [803]; N-(2-(5-aminopyridin-3-yl)-1,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [804]; N-(2-(5-aminopyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [805]; N-(2-(5-aminopyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [806]; N-(2-(6-aminopyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [807]; N-(2-(6-(methylamino)pyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [808]; N-(2-(5-(isopropylamino)pyridin-3-yl)-1,6-naphthyridin-7-yl)-3-(piperidin-4-yl)benzamide [809]; N-(2-(5-(isopropylamino)pyridin-3-yl)-1,6-naphthyridin-7-yl)-3-(1-methylpiperidin-4-yl) benzamide [810]; N-(2-(5-(isopropylamino)pyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [811]; N-(2-(5-(piperidin-4-ylamino)pyridin-3-yl)-1,6-naphthyridin-7-yl)cyclohexanecarboxamide [812]; 4-fluoro-N-(2-(5-(piperidin-4-ylamino)pyridin-3-yl)-1,6-naphthyridin-7-yl)benzamide [813]; 4-fluoro-N-(2-(5-((1-methylpiperidin-4-yl)amino)pyridin-3-yl)-1,6-naphthyridin-7-yl)benzamide [814]; N-(2-(5-acetamidopyridin-3-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [815]; N-(2-(5-(dimethylamino)pyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [816]; N-(2-(6-(dimethylamino)pyridin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [817]; 1-methyl-N-(2-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [818]; N-(2-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl)cyclopropanecarboxamide [819]; 4-fluoro-N-(2-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl)benzamide [820]; N-(2-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1,6-naphthyridin-7-yl) cyclopropanecarboxamide [821]; 4-fluoro-N-(2-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1,6-naphthyridin-7-yl) benzamide [822]; N-(2-(5-(piperazin-1-ylmethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl)cyclopropanecarboxamide [823]; N-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-3-yl)-1,6-naphthyridin-7-yl) cyclopropanecarboxamide [824]; N-(2-(5-(morpholinomethyl)pyridin-3-yl)-1,6-naphthyridin-7-yl)cyclopropanecarboxamide [825]; N-methyl-5-(7-(1-methylpiperidine-4-carboxamido)-1,6-naphthyridin-2-yl)nicotinamide [826]; N-methyl-5-(7-(2-(4-methylpiperazin-1-yl)isonicotinamido)-1,6-naphthyridin-2-yl)nicotinamide [827]; N-(2-(pyridin-3-yl-d 4 )-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [828]; 2-(4-methylpiperazin-1-yl)-N-(2-(pyridin-3-yl-d 4 )-1,6-naphthyridin-7-yl)acetamide [829]; 2-morpholino-N-(2-(pyridin-3-yl-d 4 )-1,6-naphthyridin-7-yl)acetamide [830]; 1-methyl-N-(2-(2-methylpyrimidin-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [831]; 2-(4-methylpiperazin-1-yl)-N-(2-(2-methylpyrimidin-5-yl)-1,6-naphthyridin-7-yl)isonicotinamide [832]; N-(2-(2-aminopyrimidin-5-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [833]; 2-morpholino-N-(2-(pyridazin-3-yl)-1,6-naphthyridin-7-yl)acetamide [834]; 2-morpholino-N-(2-(pyridazin-4-yl)-1,6-naphthyridin-7-yl)acetamide [835]; N-(2-(pyridazin-4-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [836]; trans-3-morpholino-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)cyclobutane-1-carboxamide [837]; trans-4-(dimethylamino)-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [838]; trans-4-morpholino-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [839]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [840]; trans-4-((4-methylpiperazin-1-yl)methyl)-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [841]; N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)acetamide [842]; 1-methyl-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [843]; 4-fluoro-1-methyl-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [844]; 1-(2-fluoroethyl)-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [845]; 1-(oxetan-3-yl)-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [846]; 2-morpholino-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)acetamide [847]; 1-methyl-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)azepane-4-carboxamide [848]; 1-isobutyl-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)azepane-4-carboxamide [849]; 1-(2-hydroxy-2-methylpropyl)-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)azepane-4-carboxamide [850]; 4-(morpholinomethyl)-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)benzamide [851]; 2-(4-methylpiperazin-1-yl)-N-(2-(pyrazin-2-yl)-1,6-naphthyridin-7-yl)isonicotinamide [852]; N-(2-(6-(methylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [853]; N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)azetidine-3-carboxamide [854]; N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [855]; N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-1-methylpiperidine-4-carboxamide [856]; 1-(2-fluoroethyl)-N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [857]; 1-isopropyl-N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [858]; 1-isopentyl-N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [859]; N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-3-(piperidin-4-yl)benzamide [860]; N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-3-(1-methylpiperidin-4-yl) benzamide [861]; N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [862]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-1H-1,2,3-triazole-4-carboxamide [863]; N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-1-(1-isopropylpiperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [864]; N-(2-(6-(isopropylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [865]; N-(2-(6-(tert-butylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-(3-(dimethylamino)azetidin-1-yl)isonicotinamide [866]; N-(2-(6-(tert-butylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-1\u2032-methyl-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [867]; N-(2-(6-(tert-butylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [868]; N-(2-(6-(tert-butylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-(4-isopropylpiperazin-1-yl) isonicotinamide [869]; N-(2-(6-(tert-butylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-morpholinoisonicotinamide [870]; N-(2-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) cyclopropanecarboxamide [871]; 4-fluoro-N-(2-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) benzamide [872]; N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)cyclobutanecarboxamide [873]; 3,3-difluoro-N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)cyclobutane-1-carboxamide [874]; N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)cyclopentanecarboxamide [875]; 4,4-difluoro-N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [876]; N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)tetrahydro-2H-pyran-4-carboxamide [877]; 4-fluoro-N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)benzamide [878]; N-(2-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) cyclopropanecarboxamide [879]; 4-fluoro-N-(2-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) benzamide [880]; N-(2-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) cyclobutanecarboxamide [881]; N-(2-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) cyclopentanecarboxamide [882]; 4-fluoro-N-(2-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)benzamide [883]; N-(2-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) cyclopropanecarboxamide [884]; 3,3-difluoro-N-(2-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) cyclobutane-1-carboxamide [885]; N-(2-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) cyclopentanecarboxamide [886]; 4-fluoro-N-(2-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl) benzamide [887]; N-(2-(6-(dimethylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [888]; N-(2-(6-(diethylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [889]; N-(2-(6-(3-aminoazetidin-1-yl)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-4-fluorobenzamide [890]; 2-(4-methylpiperazin-1-yl)-N-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl)-1,6-naphthyridin-7-yl) isonicotinamide [891]; N-(2-(6-(azetidin-3-ylmethoxy)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-4-fluorobenzamide [892]; N-(2-(6-(azetidin-3-yloxy)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-4-fluorobenzamide [893]; N-(2-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [894]; N-(2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [895]; N-(2-(1H-pyrrolo[2,3-c]pyridin-4-yl)-1,6-naphthyridin-7-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [896]; N-(2-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [897]; N-(2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [898]; N-(2-(1H-pyrrolo[2,3-c]pyridin-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [899]; 2-(4-methylpiperazin-1-yl)-N-(2-(oxazolo[5,4-b]pyridin-6-yl)-1,6-naphthyridin-7-yl) isonicotinamide [900]; N-(2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [901]; N-(2-(3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [902]; N-(2-(2-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [903]; N-(2-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [904]; N-(2-(5H-pyrrolo[2,3-b]pyrazin-3-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [905]; 1-isopropyl-N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [906]; 1-isopropyl-N-(2-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [907]; trans-4-((2-fluoroethyl)amino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [4535]; trans-4-((2-methoxyethyl)amino)-N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl) cyclohexane-1-carboxamide [4536]; tert-butyl (trans-4-((2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)carbamoyl)cyclohexyl) carbamate [4537]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-((1-methylpiperidin-4-yl)amino) isonicotinamide [4538]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide [4539]; N-(2-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide [4540]; N-(2-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)-1,6-naphthyridin-7-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [4541]; N-(2-(1-methyl-1H-1,2,3-triazol-4-yl)-1,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [4542]; N-(2-(1-methyl-1H-tetrazol-5-yl)-1,6-naphthyridin-7-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [4543]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(pyrrolidin-1-yl)propanamide [4544]; N-(2-(1,2-dimethyl-1H-imidazol-5-yl)-1,6-naphthyridin-7-yl)-2-(piperidin-1-yl)propanamide [4545]; 4-isopropoxy-N-(2-(7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-1,6-naphthyridin-7-yl)benzamide [4546]; trans-3-morpholino-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)cyclobutane-1-carboxamide [4547]; trans-4-(hydroxymethyl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [4548]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-4-carboxamide [4549]; 4-morpholino-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)piperidine-1-carboxamide [4550]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [4551]; N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-3-(piperidin-4-yloxy)benzamide [4552]; 2-methyl-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [4553]; 2-(1H-imidazol-1-yl)-N-(2-(oxazol-5-yl)-1,6-naphthyridin-7-yl)acetamide [4554]; trans-4-(hydroxymethyl)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [4555]; trans-4-(dimethylamino)-N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [4556]; N-(2-(thiazol-5-yl)-1,6-naphthyridin-7-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [4557]; trans-4-(hydroxymethyl)-N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [4558]; trans-4-(dimethylamino)-N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)cyclohexane-1-carboxamide [4559]; N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [4560]; N-(2-(2-methylthiazol-5-yl)-1,6-naphthyridin-7-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [4561]; 2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(2-(5-methyl-1,3,4-thiadiazol-2-yl)-1,6-naphthyridin-7-yl)acetamide [4562]; N-(2-(5-(cyano(4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1,6-naphthyridin-7-yl) cyclopropanecarboxamide [4563]; 4-fluoro-N-(2-(6-((1-methylazetidin-3-yl)methoxy)pyrazin-2-yl)-1,6-naphthyridin-7-yl) benzamide [4564]; 1-isopropyl-N-(2-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)-1,6-naphthyridin-7-yl)-1H-pyrazole-4-carboxamide [4565]; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 97.0
- Lexical Diversity: 1.45902
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15498990', '15749587', '15749923', '15749910', '15749922']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8252832429355269
- 35 USC 102 Novelty (BERT): 0.5926982171804475
- Combined Prediction Score: 0.8020247403600189
- Mean Citation Score: 444.7209820000001
- Max Citation Score: 527.2941
- Similarity Product: 448.5069663485348

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test