PATENT CLAIM ANALYSIS

Application Number: 16046696
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "241000"]

Abstract:
Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.

Claim (Index 3):
The method of  claim 1  wherein the bacterial efflux pump inhibitor is a compound of formula III: or a pharmaceutically acceptable salt thereof, wherein: A is \u2014C(\u2550O)N(R a1 )\u2014R 1B , \u2014(C 1 -C 3 )alkyl-C(\u2550O)N(R a1 )R 1B , \u2014(C 1 -C 3 )alkyl-O\u2014R 1B , \u2014O\u2014R 1B , \u2014(C 1 -C 3 )alkyl-N(R a1 )\u2014R 1B , or \u2014N(R a1 )\u2014R 1B ; each R 1B  is independently a (C 3 -C 7 )carbocyclyl, (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl-, 4-7 membered monocyclic heterocyclyl, or 4-7 membered monocyclic heterocyclyl-(C 1 -C 4 )alkyl-, wherein each (C 3 -C 7 )carbocyclyl or (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl- is independently substituted with one or more groups selected from the group consisting of Z and \u2014(C 1 -C 6 )alkyl substituted with one or more Z, and wherein each 4-7 membered monocyclic heterocyclyl or 4-7 membered monocyclic heterocyclyl-(C 1 -C 4 )alkyl- is independently optionally substituted with one or more groups selected from the group consisting of Z and \u2014(C 1 -C 6 )alkyl substituted with one or more Z, wherein each Z is independently selected from the group consisting of NR b2 R c2 , \u2014NHNH 2 , \u2014C(\u2550NR a2 )(R b2 R c2 ), \u2014NR a2 C(\u2550NR a2 )(R d2 ), and \u2014NR a2 C(\u2550NR a2 )(NR b2 R c2 ) and wherein each (C 3 -C 7 )carbocyclyl, (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl-, 4-7 membered monocyclic heterocyclyl, or 4-7 membered monocyclic heterocyclyl-(C 1 -C 4 )alkyl-, is independently optionally substituted independently with one or more (C 1 -C 4 )alkyl; R 2B  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy and (C 1 -C 4 )haloalkoxy; R 3B  is hydrogen, halo, (C 1 -C 6 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, \u2014NO 2 , \u2014CN, (C 1 -C 6 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 6 )alkoxy and (C 1 -C 4 )haloalkoxy; R 4B  is hydrogen, halo, (C 1 -C 6 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, \u2014NO 2 , \u2014CN, (C 1 -C 6 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 6 )alkoxy and (C 1 -C 4 )haloalkoxy; R 5B  is hydrogen, halo, (C 1 -C 6 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 6 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, \u2014NO 2 , \u2014CN, (C 1 -C 6 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 6 )alkoxy and (C 1 -C 4 )haloalkoxy; R 6B  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from halo, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy and C 1 -C 4 )haloalkoxy; each R a1  is independently hydrogen, (C 1 -C 6 )alkyl or (C 3 -C 7 )carbocyclyl; each R a2  is independently hydrogen, (C 1 -C 6 )alkyl or (C 3 -C 7 )carbocyclyl; each R b2  and R c2  is independently hydrogen, (C 1 -C 6 )alkyl or (C 3 -C 7 )carbocyclyl; and R d2  is (C 1 -C 6 )alkyl or (C 3 -C 7 )carbocyclyl.

Metadata:
- Claim Count in Document: 25.0
- Percentile: 95.0
- Lexical Diversity: 1.75
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15066911', '15323081', '15296601', '11791928', '13066616']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8321143491394317
- 35 USC 102 Novelty (BERT): 0.5454252955899244
- Combined Prediction Score: 0.803445443784481
- Mean Citation Score: 388.26477400000016
- Max Citation Score: 418.62888
- Similarity Product: 281.0714767240762

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test