PATENT CLAIM ANALYSIS

Application Number: 15902109
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "030000"]

Abstract:
Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.

Claim (Index 11):
A method of treating inflammatory lesions of rosacea in a subject in need thereof, comprising topically administering, once daily, to a skin area affected by the inflammatory lesions a pharmaceutical composition comprising 1% by weight ivermectin and a pharmaceutically acceptable carrier, wherein as early as 2 weeks after the initial administration of the pharmaceutical composition to the subject, a significant reduction in inflammatory lesion count is observed and a steady state of plasma concentration of ivermectin is reached in the subject, and the steady state has a mean C max  of ivermectin of 2.10\u00b11.04 ng/mL with a range of 0.69-4.02 ng/mL, and a mean AUC 0-24hr  of 36.14\u00b115.56 ng.hr/mL with a range of 13.69-75.16 ng.hr/mL.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 88.0
- Lexical Diversity: 1.32
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14209927', '14903906', '14257567', '14209958', '12305413']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8515294336738908
- 35 USC 102 Novelty (BERT): 0.713636633454484
- Combined Prediction Score: 0.8377401536519501
- Mean Citation Score: 658.232292
- Max Citation Score: 771.43475
- Similarity Product: 765.3475428388865

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test