PATENT CLAIM ANALYSIS

Application Number: 15781361
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["560", "055000"]

Abstract:
The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silica gel column chromatography where the used silica gel is irregular silica gel or spherical silica gel an as eluent and eluent mixture consisting of an apolar and a polar solvent is used and if desired, contamination of the purified compound of formula I arising from the solvents are removed by silica gel filtration chromatography.

Claim (Index 1):
Process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% characterized in that the crude Latanoprostene bunod of formula (I) is purified by chromatography, applying normal phase gravity silica gel column chromatography,\n using as silica gel \n a.) normal phase, irregular silica gel of particle size 63-200 micron, or b.) normal phase spherical silica gel of particle size 50-150 micron, and\n as eluent, an eluent mixture consisting of an apolar and a polar solvent, \n and if desired, impurities arising from the eluents used for purification chromatography of compound of formula (I) are removed by silica gel filtration chromatography.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 94.0
- Lexical Diversity: 1.56897
- Patent Class: 560.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15117092', '12999112', '12865581', '11189985', '13884422']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7565801394062424
- 35 USC 102 Novelty (BERT): 0.5614365898411446
- Combined Prediction Score: 0.7370657844497326
- Mean Citation Score: 244.068288
- Max Citation Score: 371.75714
- Similarity Product: 264.789427500143

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test