PATENT CLAIM ANALYSIS

Application Number: 15893507
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-10
Patent Classification: ["435", "006120"]

Abstract:
Providing herein, among other things, is a method for preparing a nucleic acid for sequencing. In some embodiments, the method comprises a) amplifying a nucleic acid template using a dNTP mix that contains 5-methyl dCTP, thereby producing product nucleic acid molecules that contains methylcytosines; b) digesting the product nucleic acid molecules with a methylation-dependent restriction endonuclease, thereby cleaving the product nucleic acid molecules at sites that are adjacent to at least some of the methylcytosine and producing fragments of the product nucleic acid molecules; and c) ligating double-stranded adaptors onto the ends of the fragments to produce adaptor-ligated products.

Claim (Index 12):
The method of  claim 1 , wherein the double-stranded adaptors of step c) comprise a four base 5\u2032 overhang of random sequence.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 88.0
- Lexical Diversity: 1.79032
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13643056', '14390012', '11071864', '13384990', '14716212']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5441121792138836
- 35 USC 102 Novelty (BERT): 0.5167392273691674
- Combined Prediction Score: 0.5413748840294119
- Mean Citation Score: 253.56801
- Max Citation Score: 261.72006
- Similarity Product: 164.14687684685111

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test