PATENT CLAIM ANALYSIS

Application Number: 15751777
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "255050"]

Abstract:
Compounds of the Formula (I) are provided which compounds inhibitors of BACE1.

Claim (Index 13):
A compound selected form the group consisting of\n N-(3-((3S,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5-tetrahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-(methoxy-d 3 )picolinamide, N-(3-((3S,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide, N-(3-((3S,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide, N-(3-((3S,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-methoxypicolinamide, N-(3-((3S,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide, N-(3-((3S,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-chloropicolinamide, N-(3-((3R,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide, N-(3-((3R,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide, N-(3-((3R,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-4-methylthiazole-2-carboxamide, N-(3-((3R,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-2-methyloxazole-4-carboxamide, N-(3-((3R,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-methoxypicolinamide, N-(3-((3R,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide, N-(3-((3R,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5-tetrahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-(methoxy-d 3 )pyrazine-2-carboxamide, N-(3-((3R,4aR,7aS)-2-amino-3,4a-difluoro-3-methyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-chloropicolinamide, N-(3-((3R,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-3,4,4a,5-tetrahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-methoxypicolinamide, N-(3-((3R,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-3,4,4a,5-tetrahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide, N-[3-[(3R,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-4,4a,5,7-tetrahydrofuro[3,4-b]pyridin-7a-yl]-4,5-difluoro-phenyl]-5-methoxy-pyridine-2-carboxamide, N-[3-[(3R,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-4,4a,5,7-tetrahydrofuro[3,4-b]pyridin-7a-yl]-4,5-difluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide, N-[3-[(3R,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-4,4a,5,7-tetrahydrofuro[3,4-b]pyridin-7a-yl]-4,5-difluoro-phenyl]-5-fluoro-pyridine-2-carboxamide, N-(3-((3S,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-3,4,4a,5-tetrahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide, N-(3-((3S,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-methoxypicolinamide, N-(3-((3S,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-3,4,4a,5-tetrahydrofuro[3,4-b]pyridin-7a-yl)-4-fluorophenyl)-5-(methoxy-d 3 )picolinamide, N-[3-[(3S,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-4,4a,5,7-tetrahydrofuro[3,4-b]pyridin-7a-yl]-4,5-difluoro-phenyl]-5-fluoro-pyridine-2-carboxamide, N-[3-[(3S,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-4,4a,5,7-tetrahydrofuro[3,4-b]pyridin-7a-yl]-4,5-difluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide and N-[3-[(3S,4aS,7aS)-2-amino-3-fluoro-3-(fluoromethyl)-4,4a,5,7-tetrahydrofuro[3,4-b]pyridin-7a-yl]-4,5-difluoro-phenyl]-5-methoxy-pyridine-2-carboxamide, or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 1.07143
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13386199', '14057403', '13979961', '12355154', '13978062']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8494355977640985
- 35 USC 102 Novelty (BERT): 0.5764630966413373
- Combined Prediction Score: 0.8221383476518224
- Mean Citation Score: 447.21921799999984
- Max Citation Score: 478.95218
- Similarity Product: 427.8283685655594

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test