PATENT CLAIM ANALYSIS

Application Number: 16274123
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "001100"]

Abstract:
Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

Claim (Index 63):
The rcHC-HA/PTX3 complex of any of  claims 46 - 48  or isolated nHC-HA/PTX3 complex of any of  claims 49 - 61 , wherein:\n (i) the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex reduces the expression of IL-12p40 in LPS-stimulated macrophages, wherein the level of IL-12p40 expressed by LPS-stimulated macrophages is lower when the LPS-stimulated macrophages are contacted with the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex compared to the level of IL-12p40 expressed by LPS-stimulated macrophages in the absence of the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex; \n (ii) the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex reduces the expression of IL-12p70 protein in LPS-stimulated macrophages, wherein the amount of IL-12p70 protein expressed by LPS-stimulated macrophages is lower when the LPS-stimulated macrophages are contacted the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex compared to the amount of IL-12p70 protein expressed by LPS-stimulated macrophages in the absence of the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex; \n (iii) the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex reduces the expression of IL-23 in LPS-stimulated macrophages, wherein the level of IL-23 expressed by LPS-stimulated macrophages is lower when the LPS-stimulated macrophages are contacted the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex compared to the level of IL-23 expressed by LPS-stimulated macrophages in the absence of the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex; \n (iv) the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex increases the expression of IL-10 in LPS-stimulated macrophages, wherein the level of IL-10 expressed by LPS-stimulated macrophages is higher when the LPS-stimulated macrophages are contacted the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex compared to the level of IL-10 expressed by LPS-stimulated macrophages in the absence of rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex; \n (v) the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex promotes apoptosis of LPS-stimulated neutrophils, wherein the number of LPS-stimulated neutrophils that are apoptotic in a sample of LPS-stimulated neutrophils is higher when the sample is contacted the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex compared to the number of LPS-stimulated neutrophils that are apoptotic in the sample in the absence of the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex; \n (vi) the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex promotes phagocytosis of apoptotic neutrophils, wherein the number of apoptotic neutrophils that are phagocytosed by LPS-stimulated or resting macrophages in a sample of apoptotic neutrophils and LPS-stimulated or resting macrophages is higher when the sample is contacted the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex compared to the number of neutrophils that are phagocytosed by LPS-stimulated or resting macrophages in the sample in the absence of the rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex.

Metadata:
- Claim Count in Document: 87.0
- Percentile: 99.0
- Lexical Diversity: 1.63158
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14414047', '15214706', '15160487', '13262725', '13782968']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8387328087527158
- 35 USC 102 Novelty (BERT): 0.6055541845208927
- Combined Prediction Score: 0.8154149463295335
- Mean Citation Score: 614.755842
- Max Citation Score: 879.9582
- Similarity Product: 458.5493514847398

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test