PATENT CLAIM ANALYSIS

Application Number: 15752323
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-02
Patent Classification: ["528", "50200A"]

Abstract:
A method increase of the Resolution Index (Rl) of a chromatogram generated from a polymer sample comprising at least two olefin-based polymers of different microstructures and/or at least two olefin-based polymer fractions of different microstructures. The method comprises separating the mixture on a low-porosity stationary phase and repeatedly cycling the sample-stationary phase through a series of cooling and heating stages with active eluent flow only during the cooling stages and during the last heating stage to elute the separated analytes off the column.

Claim (Index 1):
A method to increase of the Resolution Index (RI) of a chromatogram generated from a polymer sample comprising at least two olefin-based polymers of different microstructures and/or at least two olefin-based polymer fractions of different microstructures;\n said method comprising at least the following steps, and wherein one of A) or B) occurs: A) n\u2032=0, and steps d) and e) below are skipped, such that step f) follows step c), and wherein T3 0  is greater than T1 0 ; B) n\u2032 is an integer \u22651; steps d) and e) are not skipped; and steps d) and e) are repeated for n\u2032>1; a1) dissolving the polymer sample in at least one solvent to form a polymer solution; a2) injecting at least a portion of the polymer solution onto a stationary phase at a temperature T1 0  (in \u00b0 C.), and wherein no eluent flow through the stationary phase; b) setting a constant eluent flow rate (FR 0 ) through the stationary phase, while simultaneously cooling the stationary phase at a cooling rate CR 0 , to a minimum temperature T2 0  (in \u00b0 C.), where T2 0 <T1 0 ; and wherein the flow of the eluent through the stationary phase is stopped at temperature T2 0 ; c) when the temperature reaches T2 0 , optionally maintaining the temperature at T2 0  for a time t 20 ; increasing the temperature of the stationary phase to T3 0 , at a heating rate HR 0 , where T3 0 >T2 0 , while maintaining no flow of eluent through the stationary phase; and when the temperature reaches temperature T3 0 , maintaining no flow rate through the stationary phase a time t 30 ; and maintaining the temperature at T3 0  for the time t 30 ; wherein for steps d) and e) below, at each n value, where n is from 1 to n\u2032, the eluent flow rate of step d) is FR n ; and wherein at least one T3 n  (for n\u22651) is greater than T1 0 ; d) setting a constant eluent flow rate (FR n ) through the stationary phase, while simultaneously cooling the stationary phase at a rate CR n , to a minimum temperature T2 n , where T2 n <T3 n-1 ; and wherein the flow of the eluent through the stationary phase is stopped at temperature T2 n ; e) when the temperature reaches T2 n , optionally maintaining the temperature at T2 n  for a time t 2n ; increasing the temperature of the stationary phase to T3 n , at a heating rate HR n , where T3 n >T2 n , while maintaining no flow of eluent through the stationary phase; and when the temperature reaches temperature T3 n , maintaining no flow rate through the stationary phase for a time t 3n ; and maintaining the temperature of the stationary phase at T3 n  for the time t 3n ; f) setting a constant eluent flow rate (FR f ) through the stationary phase, while simultaneously cooling the stationary phase at a rate CR f  to a temperature T2 f , and when the temperature reaches temperature T2 f , optionally maintaining the temperature at T2 f  for a time t 2f ; g) increasing the flow rate (FRe) of the eluent through the stationary phase to at least 0.1 ml/min, while increasing the temperature of the stationary phase to T f  (T f >T2 f  and T f \u2265T1 0 ), and eluting the polymer sample from the stationary phase during this temperature increase; and when the stationary phase reaches temperature T f , optionally maintaining the temperature at T f  for a time t f ; and generating the chromatogram; and wherein the resolution index (RI)=((RC\u2212R0)/R0)\u00d7100; and where RI>zero; and wherein RC is the difference in the elution times of two peak height maximums on the chromatogram; and wherein R0 is the difference in the elution times of the same two peaks height maximums selected for the determination of RC, and wherein these two peak height maximums are present on a comparative chromatogram, generated under the same conditions as the chromatogram for RC, except that the following steps were used in the analysis: c1) injecting at least a portion of the polymer solution onto a stationary phase at a temperature T1 0  (in \u00b0 C.), and wherein no eluent flow through the stationary phase; c2) setting a constant eluent flow rate (FR 0 ) through the stationary phase, while simultaneously cooling the stationary phase at a cooling rate CR 0 , to a minimum temperature T2 0  (in \u00b0 C.), where T2 0 <T1 0 ; and wherein the flow of the eluent through the stationary phase is stopped at temperature T2 0 , optionally maintaining the temperature at T2 0  for a period t 20 ; c3) increasing the flow rate (FRe) of the eluent through the stationary phase at a rate of at least 0.1 ml/min, while increasing the temperature of the stationary phase to T f  (T f >T2 0  and T f \u2265T1 0 ), and eluting the polymer sample from the stationary phase during this temperature increase; and when the stationary phase reaches temperature T f , optionally maintaining the temperature at T f  for a time t f ; and generating the comparative chromatogram.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 88.0
- Lexical Diversity: 1.5
- Patent Class: 528.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14119403', '13512387', '12643111', '13405487', '15567439']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7260696027669343
- 35 USC 102 Novelty (BERT): 0.5014745229356556
- Combined Prediction Score: 0.7036100947838064
- Mean Citation Score: 204.63878
- Max Citation Score: 258.2942
- Similarity Product: 172.20850107901092

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test