PATENT CLAIM ANALYSIS

Application Number: 15743489
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["546", "065000"]

Abstract:
The present invention relates to the compounds of formula I, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with cancers associated with protein kinases, to their use as medicaments for use in the production of inhibition of mTor, pi3k reducing effects in warm¬blooded animals such as humans.

Claim (Index 4):
A compound according to  claim 1  that is selected from the group consisting of:\n 16-(4-tert-butylphenyl)-4-(bromo-3-yl)-12-methyl-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 16-(4-tert-butylphenyl)-4-(bromo-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 2-(4-{4-bromo-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl}phenyl)-2-methylpropanenitrile; \n 16-(4-tert-butylphenyl)-4-(bromo-3-yl)-12-methyl-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 2-(4-{4-bromo-12-ethyl-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl}phenyl)-2-methylpropanenitrile; \n 16-(4-tert-butylphenyl)-4-(bromo-3-yl)-12-ethyl-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 2-methyl-2-{4-[12-methyl-4-(quinolin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}propanenitrile; \n 2-methyl-2-{4-[4-(quinolin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}propanenitrile; \n 2-{4-[12-ethyl-4-(pyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}-2-methylpropanenitrile; \n 2-methyl-2-{4-[4-(pyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}propanenitrile; \n 2-methyl-2-{4-[12-methyl-4-(pyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}propanenitrile; \n 1-{4-[4-(quinolin-3-yl)-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}cyclopentane-1-carbonitrile; \n 1-{4-[12-methyl-4-(pyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}cyclopentane-1-carbonitrile; \n 1-{4-[12-methyl-4-(pyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}cyclopropane-1-carbonitrile; \n 2-methyl-2-{4-[12-methyl-4-(pyridin-4-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}propanenitrile \n 4-(4-fluorophenyl)-12-methyl-16-[4-(2-methylbut-3-yn-2-yl)phenyl]-8,11,13,14,16-pentaaza-tetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 4-(3-fluorophenyl)-12-methyl-16-[4-(2-methylbut-3-yn-2-yl)phenyl]-8,11,13,14,16-pentaaza-tetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 4-(3,4-difluorophenyl)-12-methyl-16-[4-(2-methylbut-3-yn-2-yl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 4-(2-fluorophenyl)-12-methyl-16-[4-(2-methylbut-3-yn-2-yl)phenyl]-8,11,13,14,16-pentaaza-tetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 16-(4-tert-butylphenyl)-12-methyl-4-{1H-pyrrolo[2,3-b]pyridin-5-yl}-8,11,13,14,16-pentaaza-tetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n N-{5-[16-(4-tert-butylphenyl)-12-methyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-yl}acetamide; \n 16-(4-tert-butylphenyl)-4-(6-methoxypyridin-3-yl)-12-methyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 16-(4-tert-butylphenyl)-12-methyl-4-(pyrimidin-5-yl)-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 16-(4-tert-butylphenyl)-12-methyl-4-(pyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 2-{4-[4-(6-aminopyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}-2-methylpropanenitrile; \n 2-methyl-2-{4-[4-(pyrimidin-5-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}propanenitrile; \n N-{5-[16-(4-tert-butylphenyl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-yl}acetamide; \n 16-(4-tert-butylphenyl)-4-{1H-pyrrolo[2,3-b]pyridin-5-yl}-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 5-[16-(4-tert-butylphenyl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-amine; \n 5-[16-(4-tert-butylphenyl)-12-methyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-amine; \n 16-(4-tert-butylphenyl)-4-(6-methoxypyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 16-(4-tert-butylphenyl)-4-(pyrimidin-5-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 16-(4-tert-butylphenyl)-4-(pyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 2-[4-(12-ethyl-4-{1H-pyrrolo[2,3-b]pyridin-5-yl}-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl)phenyl]-2-methylpropanenitrile; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-12-ethyl-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)acetamide; \n 5-{12-ethyl-16-[4-(2-methylbut-3-yn-2-yl)phenyl]-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-amine; \n 2-{4-[12-ethyl-4-(pyrimidin-5-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}-2-methylpropanenitrile; \n 12-ethyl-4-(6-methoxypyridin-3-yl)-16-[4-(2-methylbut-3-yn-2-yl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1 (10),2,4,6,8,12,14-heptaene; \n 2-methyl-2-[4-(4-{1H-pyrrolo[2,3-b]pyridin-4-yl}-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl)phenyl]propanenitrile; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-12-methyl-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)acetamide; \n 2-methyl-2-{4-[12-methyl-4-(pyrimidin-5-yl)-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}propanenitrile; \n 4-(6-methoxypyridin-3-yl)-12-methyl-16-[4-(2-methylbut-3-yn-2-yl)phenyl]8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 2-methyl-2-[4-(12-methyl-4-{1H-pyrrolo[2,3-b]pyridin-5-yl}-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl)phenyl]propanenitrile; \n 2-{4-[4-(6-aminopyridin-3-yl)-12-methyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}-2-methylpropanenitrile; \n 5-[16-(4-tert-butylphenyl)-12-methyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexa-deca-1(10),2,4,6,8,12,14-heptaen-4-yl]-4-(trifluoromethyl)pyridin-2-amine; \n 5-[16-(4-tert-butylphenyl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]-4-(trifluoromethyl)pyridin-2-amine; \n 16-(4-tert-butylphenyl)-12-ethyl-4-(pyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene; \n 5-[16-(4-tert-butylphenyl)-12-ethyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-amine; \n 2-(4-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-8,11,13,14,16-pentaazatetracyclo-[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl}phenyl)-2-methylpropanenitrile; \n 2-{4-[4-(6-aminopyridin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}-2-methylpropanenitrile; \n 5-[16-(4-tert-butylphenyl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-amine; \n 2-amino-N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(cyclopentylamino)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(cyclohexylamino)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(oxan-4-ylamino)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(thian-4-ylamino)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(dimethylamino)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(methylamino)acetamide; \n 16-(4-tert-butylphenyl)-4-(quinolin-3-yl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaene; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(4-oxopiperidin-1-yl)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(4-hydroxypiperidin-1-yl)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(4-methylpiperazin-1-yl)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(morpholin-4-yl)acetamide; \n N-(5-{16-[4-(1-cyano-1-methylethyl)phenyl]-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl}pyridin-2-yl)-2-(pyrrolidin-1-yl)acetamide; \n N-{5-[16-(4-tert-butylphenyl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-yl}-2-(pyrrolidin-1-yl)acetamide; \n N-{5-[16-(4-tert-butylphenyl)-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-yl}-2-(methylamino)acetamide; \n N-{5-[16-(4-tert-butylphenyl)-12-ethyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-yl}-2-(methylamino)acetamide; \n N-{5-[16-(4-tert-butylphenyl)-12-ethyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-yl}-2-(pyrrolidin-1-yl)acetamide; \n 5-[16-(4-tert-butylphenyl)-12-ethyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]-N-methylpyridin-2-amine; \n 5-[16-(4-tert-butylphenyl)-12-ethyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]-N-(2-methoxyethyl)pyridin-2-amine; \n 5-[16-(4-tert-butylphenyl)-12-ethyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]-N-[2-(pyrrolidin-1-yl)ethyl]pyridin-2-amine; \n 5-[16-(4-tert-butylphenyl)-12-ethyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]-N-[2-(morpholin-4-yl)ethyl]pyridin-2-amine; \n N-{5-[16-(4-tert-butylphenyl)-12-ethyl-8,11,13,14,16-pentaazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-4-yl]pyridin-2-yl}-2-(morpholin-4-yl)acetamide; \n 2-(4-{4-bromo-8,11,14,16-tetraazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),-2,4,6,8,12,14-heptaen-16-yl}phenyl)-2-methylpropanenitrile \n 2-methyl-2-{4-[4-(pyridin-3-yl)-8,11,14,16-tetraazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaen-16-yl]phenyl}propanenitrile \n 4-bromo-16-(4-tert-butylphenyl)-8,11,14,16-tetraazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]hexadeca-1(10),2,4,6,8,12,14-heptaene \n 16-(4-tert-butylphenyl)-4-(pyridin-3-yl)-8,11,14,16-tetraazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaene \n 16-(4-tert-butylphenyl)-4-(quinolin-3-yl)-8,11,14,16-tetraazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaene \n 16-(3-tert-butylphenyl)-4-(quinolin-3-yl)-8,11,14,16-tetraazatetracyclo[8.6.0.0 2 , 7 .0 11 , 15 ]-hexadeca-1(10),2,4,6,8,12,14-heptaene \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 1.42222
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15325593', '14123934', '11294316', '12159742', '11378947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8115734311870602
- 35 USC 102 Novelty (BERT): 0.5900658879545857
- Combined Prediction Score: 0.7894226768638127
- Mean Citation Score: 292.0053919999998
- Max Citation Score: 508.21484
- Similarity Product: 457.5630394711876

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test