PATENT CLAIM ANALYSIS

Application Number: 16001295
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "255050"]

Abstract:
The present invention is directed to pyrazolopyrimidine compounds which may be useful as therapeutic agents for the treatment of disorders associated with phosphodiesterase 9 (PDE9). The present invention also relates to the use of such compounds for treating cardiovascular and cerebrovascular diseases, such as hypertension, chronic kidney disease and heart failure, and neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Claim (Index 1):
A compound of the formula I: wherein: A is a cyclobutyl ring, which is unsubsubstituted or or substituted with substituents selected from: fluoro and methyl; R 1 , R 2  and R 3  are independently selected from:\n (1) hydrogen, \n (2) halogen, \n (3) hydroxyl, \n (4) C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from: hydroxy and fluoro, \n (5) \u2014O\u2014C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from fluoro, \n (6) C 3-6 cycloalkyl, \n (7) C 2-6 alkynyl, and \n (8) \u2014CN; \n R 4  is selected from:\n (1) hydrogen, \n (2) \u2014CH 3 ; \n (3) \u2014CF 3 ,\n (4) \u2014CH 2 OH, \n (5) \u2014CO 2 H, and \n (6) \u2014CH 2 CH 3 ; \n R 5  is a phenyl, pyridyl, pyrazinyl, pyrazolyl, pyrimidinyl, pyridazinyl, thiazolyl, cyclohexyl or tetrahydropyranyl ring, wherein the phenyl, pyridyl, pyrazinyl, pyrazolyl, pyrimidinyl, pyridazinyl, thiazolyl, cyclohexyl or tetrahydropyranyl ring is substituted with R 1a , R 1b  and R 1c , wherein R 1a , R 1b  and R 1c  are independently selected from:\n (1) hydrogen, \n (2) halogen, \n (3) hydroxyl, \n (4) C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from: hydroxy and fluoro, \n (5) \u2014O\u2014C 1-6 alkyl, which is unsubstituted or substituted with substituents selected from fluoro, \n (6) C 3-6 cycloalkyl, and \n (7) \u2014CN; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 94.0
- Lexical Diversity: 1.47368
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15574411', '12693480', '13699046', '14858159', '14420003']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7704400165407971
- 35 USC 102 Novelty (BERT): 0.5344979668132243
- Combined Prediction Score: 0.7468458115680399
- Mean Citation Score: 321.370304
- Max Citation Score: 341.53876
- Similarity Product: 245.2747643367911

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test