PATENT CLAIM ANALYSIS

Application Number: 16389355
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["514", "157000"]

Abstract:
The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.

Claim (Index 1):
A compound of Formula (II): wherein:\n ring A is a monocyclic or bicyclic aryl or a monocyclic or bicyclic heteroaryl ring, and wherein the aryl or heteroaryl ring is optionally substituted with 1-4 R 1  groups; \n ring B is a monocyclic or bicyclic arenediyl or a monocyclic or bicyclic heteroarenediyl ring, and wherein the arenediyl or heteroarenediyl ring is optionally substituted with 1-4 R 2  groups; \n each occurrence of R 1  and R 2  is independently selected from the group consisting of C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 1 -C 6  heteroalkyl, F, Cl, Br, I, \u2014CN, \u2014NO 2 , \u2014OR 5 , \u2014SR 5 , \u2014S(\u2550O)R 5 , \u2014S(\u2550O) 2 R 5 , \u2014(CH 2 ) 0-2 NHS(\u2550O) 2 R 5 , \u2014(CH 2 ) 0-2 C(\u2550O)R 5 , \u2014OC(\u2550O)R 5 , \u2014(CH 2 ) 0-2 CO 2 R 5 , \u2014OCO 2 R 5 , \u2014CH(R 5 ) 2 , \u2014(CH 2 ) 0-2 N(R 5 ) 2 , \u2014(CH 2 ) 0-2 C(\u2550O)N(R 5 ) 2 , \u2014OC(\u2550O)N(R 5 ) 2 , \u2014(CH 2 ) 0-2 NHC(\u2550O)NH(R 5 ), \u2014(CH 2 ) 0-2 NHC(\u2550O)R 5 , \u2014(CH 2 ) 0-2 NHC(\u2550O)OR 5 , \u2014C(OH)(R 5 ) 2 , and \u2014C(NH 2 )(R 5 ) 2 ; \n R 3  is selected from the group consisting of H, C 1 -C 6  alkyl, \u2014OR 5 , \u2014S(\u2550O)R 5 , \u2014S(\u2550O) 2 R 5 , \u2014C(\u2550O)R 5 , \u2014CO 2 R 5 , \u2014CH(R 5 ) 2 , and \u2014C(\u2550O)N(R 5 ) 2 ; \n R 4  is selected from the group consisting of \u2014OR 5 , \u2014SR 5 , \u2014S(\u2550O)R 5 , \u2014S(\u2550O) 2 R 5 , \u2014NHS(\u2550O) 2 R 5 , \u2014C(\u2550O)R 5 , \u2014OC(\u2550O)R 5 , \u2014CO 2 R 5 , \u2014OCO 2 R 5 , \u2014CH(R 5 ) 2 , \u2014N(R 5 ) 2 , \u2014C(\u2550O)N(R 5 ) 2 , \u2014OC(\u2550O)N(R 5 ) 2 , \u2014NHC(\u2550O)NH(R 5 ), \u2014NHC(\u2550O)R 5 , \u2014NHC(\u2550O)OR 5 , \u2014C(OH)(R 5 ) 2 , \u2014C(NH 2 )(R 5 ) 2 , C 1 -C 6  alkyl, C 3 -C 10  cycloalkyl, (C 4 -C 10 )heterocycle, (C 6 -C 10 )aryl, and (C 5 -C 10 )heteroaryl, wherein the alkyl, heteroalkyl, cycloalkyl, heterocycle, aryl and heteroaryl groups are independently optionally substituted; \n each occurrence of R 5  is independently selected from the group consisting of H, C 1 -C 6  alkyl, C 1 -C 6  heteroalkyl, C 3 -C 10  cycloalkyl, \u2014C 1 -C 3  alkyl-(C 3 -C 6  cycloalkyl), (C 4 -C 10 )heterocycle, \u2014C 1 -C 3  alkyl-(C 4 -C 10 heterocycle), (C 6 -C 10 )aryl, \u2014C 1 -C 3  alkyl-(C 6 -C 10 aryl), (C 5 -C 10 )heteroaryl, and \u2014C 1 -C 3  alkyl-(C 5 -C 10  heteroaryl), wherein the alkyl, heteroalkyl, cycloalkyl, heterocycle, aryl and heteroaryl groups are independently optionally substituted; and \n x and y are independently an integer from 0-4; \n a salt or solvate thereof, and any combinations thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 100.0
- Lexical Diversity: 1.97143
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15382002', '14784536', '14772486', '15830244', '12598882']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8420263066474385
- 35 USC 102 Novelty (BERT): 0.6385274161528777
- Combined Prediction Score: 0.8216764175979824
- Mean Citation Score: 440.32968199999993
- Max Citation Score: 696.1560000000003
- Similarity Product: 542.1212376093865

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test