PATENT CLAIM ANALYSIS

Application Number: 15864499
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "264000"]

Abstract:
The present invention relates to compounds of formula I wherein R 1 , R 4 , Ar, W, X and Z are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps1 kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Claim (Index 27):
The method according to  claim 18 , wherein Ar has the formula: wherein: (i) all of A 1 , A 2  and A 3  are CH; or (ii) one of A 1 , A 2  and A 3  is N and the others are CH; R 5  is hydrogen, cyano, (1-3C)alkyl, (1-3C)perfluoroalkyl, (1-3C)alkoxy, (1-3C)fluoroalkoxy, and halo, and wherein any alkyl or alkoxy moities present within a R 5  substituent group are optionally further substituted by hydroxy or methoxy; and R 6  is selected from halogeno, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, carboxy, carbamoyl, and sulphamoyl; or R 6  is a group of the formula:\n -L 1 -L 2 -R 17  \n wherein \n L 1  is absent or a linker group of the formula \u2014[CR 18 R 19 ] n \u2014 in which n is an integer selected from 1 and 2, and R 18  and R 19  are each independently selected from hydrogen and methyl;\n L 2  is absent or is selected from O, S, SO, SO 2 , N(R 20 ), C(O), C(O)O, OC(O), CH(OR 20 ), C(O)N(R 20 ), N(R 20 )C(O), N(R 20 )C(O)N(R 21 ), S(O) 2 N(R 20 ), and N(R 20 )SO 2 , wherein R 20  and R 21  are each independently selected from hydrogen and (1-2C)alkyl; and \n R 17  is (1-6C)alkyl, aryl, (3-6C)cycloalkyl, 5 or 6 membered heteroaryl, or 3 to 8 membered heterocyclyl, \n and wherein R 17  is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, nitro, hydroxy, NR 22 R 23 , (1-4C)alkoxy, (1-4C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-3C)alkyl, (1-5C)alkanoyl, (1-5C)alkylsulphonyl, 3 to 6 membered heterocyclyl, 3 to 6 membered heterocyclyl-(1-2C)alkyl, 5 or 6 membered heteroaryl, 5 or 6 membered heteroaryl-(1-2C)alkyl, CONR 22 R 23 , and SO 2 NR 22 R 23 ; wherein R 22  and R 23  are each independently selected from hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl, and (3-6C)cycloalkyl(1-2C)alkyl; or R 22  and R 23  can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-6 membered heterocyclic ring; \n and wherein when said substituent group comprises an alkyl, cycloalkyl, heterocyclyl or heteroaryl moiety then said moiety is optionally further substituted by hydroxy, fluoro, chloro, cyano, CF 3 , OCF 3 , (1-2C)alkyl, (1-2C)alkoxy, SO 2 (1-2C)alkyl or NR e R f  (where R e  and R f  are each independently selected from hydrogen, (1-3C)alkyl, (3-6C)cycloalkyl, and (3-6C)cycloalkyl(1-2C)alkyl);\n or R 17  is a group having the formula:\n -L 3 -L 4 -R 24  \n \n \n wherein L 3  is absent or a linker group of the formula \u2014[CR 25 R 26 ] n \u2014 in which n is an integer selected from 1, 2, 3 and 4, and R 25  and R 26  are each independently selected from hydrogen and (1-2C)alkyl; L 4  is absent or is selected from O, S, SO, SO 2 , N(R 27 ), C(O), C(O)O, OC(O), CH(OR 27 ), C(O)N(R 27 ), N(R 27 )C(O), N(R 27 )C(O)N(R 28 ), S(O) 2 N(R 27 ), and N(R 28 )SO 2 , wherein R 27  and R 28  are each independently selected from hydrogen and (1-2C)alkyl; and R 24  is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl or heterocyclyl-(1-4C)alkyl.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 86.0
- Lexical Diversity: 1.69118
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15091887', '15121432', '15069012', '14426574', '15091980']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8135348051374537
- 35 USC 102 Novelty (BERT): 0.6316077520877447
- Combined Prediction Score: 0.7953420998324828
- Mean Citation Score: 495.849256
- Max Citation Score: 593.34357
- Similarity Product: 532.2512948312259

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test