PATENT CLAIM ANALYSIS

Application Number: 15769987
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "218000"]

Abstract:
The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

Claim (Index 1):
A compound having the structure of formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is H, D, halo, cyano, hydroxyl, nitro, \u2014C(O)NR 5 R 6 , \u2014C(O)OR 5 , \u2014N\u2550N + \u2550N \u2212 , an optionally substituted C 1 -C 3  alkyl, an optionally substituted C 1 -C 3  alkoxy, \u2014S(O) 2 NR 5 R 6 , an optionally substituted 6-10 membered aryl, an optionally substituted 5-10 membered heteroaryl, \u2014S(O) 2 R 5 , \u2014OCZ 3 , \u2014OCHZ 2 , \u2014OCH 2 Z, \u2014SZ 3 , \u2014SCZ 3 , or \u2014S(Z) 5 ; \n each of R 5  or R 6  is independently H, D, an optionally substituted C 1 -C 5  alkyl, an optionally substituted C 1 -C 3  alkoxy, or R 5  and R 6 , together with the intervening atoms to which they are attached, can form a 5-6 membered ring; \n Z is a halo; \n ring B is 6-10 membered aryl, a 5-10 membered heteroaryl, or a 5-10 membered heterocyclyl; \n R 2  is H, D, halo, cyano, or an optionally substituted C 1 -C 3  alkyl; \n m is 0, 1, 2, 3, or 4; \n R 3  is H, D, or an optionally substituted C 1 -C 3  alkyl: or R 2  and R 3 , together with the intervening atoms to which they are attached, can form a 5-6 membered ring; \n L 1  is a bond; \u2014C(O)\u2014; \u2014C(O)O\u2014; \u2014OC(O)\u2014; \u2014NR 5 C(O)NR 6 \u2014; \u2014NR 5 C(O)O\u2014; \u2014C(O)NR 6 \u2014; \u2014S(O)\u2014; or \u2014S(O) 2 \u2014; \n X is CH or N; \n Y is a bond, CH, CH 2 , CH 3 , N, NH, NH 2 , O, or S; \n L 2  is a bond, an optionally substituted C 1 -C 5  alkyl, or an optionally substituted 3-10 membered cycloalkyl; \n A is \u2014NR 10 R 10 , \u2014C(O)OR 10 , an optionally substituted C 1 -C 5  alkyl, an optionally substituted 4-10 membered heterocyclyl, an optionally substituted 5-10 membered heteroaryl, an optionally substituted 6-10 membered aryl, or an optionally substituted 4-7 membered cycloalkyl; \n each R 10  independently is H, an optionally substituted C 1 -C 3  alkyl, an optionally substituted 5-7 membered heteroaryl, or an optionally substituted 6-10 membered aryl; \n p is 0, 1, 2, 3, or 4; and \n  denotes a single or double bond; \n wherein the compound is not:

Metadata:
- Claim Count in Document: 38.0
- Percentile: 91.0
- Lexical Diversity: 1.45946
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14904803', '14904801', '15130358', '15630068', '12538751']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7547341932192679
- 35 USC 102 Novelty (BERT): 0.5214812705966698
- Combined Prediction Score: 0.7314089009570082
- Mean Citation Score: 297.00774
- Max Citation Score: 301.33768
- Similarity Product: 226.7601777455044

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test