PATENT CLAIM ANALYSIS

Application Number: 16418272
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-10
Patent Classification: ["435", "007940"]

Abstract:
A method is described for the detection of at least two of cytokeratins 8, 18 and 19 in a sample. It is practiced by contacting the sample with a solid phase having a first antibody with specificity for cytokeratin 8, a second antibody with specificity for cytokeratin 18 and, optionally, a third antibody with specificity for a first epitope of cytokeratin 19 bound to it and allowing cytokeratins in the sample to bind to the bound antibodies to form complexes. The complexes are then contacted with a first labelled antibody with specificity for a dimer of cytokeratin 8 and 18 and optionally a second labelled antibody with specificity for a second epitope of cytokeratin 19 and allowing the labelled antibodies to bind to the complexes. The labelled antibodies bound to the complexes are then detected. A method for quantitative determination of soluble fragments of at least two of cytokeratin 8, 18 and 19 in a sample and a kit are also described.

Claim (Index 25):
The method according to  claim 17 , wherein the cytokeratin 8 and 18 and soluble fragments thereof in the fluid sample are detected by a method comprising the steps of:\n contacting said fluid sample with a solid phase having immobilized thereon a first antibody having specificity for cytokeratin 8, and a second antibody having specificity for cytokeratin 18; allowing cytokeratins 8 and 18 and soluble fragments thereof in said sample to bind to said first and second antibodies thereby forming complexes; contacting said complexes with a first labelled antibody having specificity for a dimer of cytokeratin 8 and 18; allowing said labelled antibodies to bind to said complexes; and detecting said labelled antibody bound to said complexes.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 100.0
- Lexical Diversity: 2.96552
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14782527', '15127644', '14992750', '13821844', '10480848']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5909332355576747
- 35 USC 102 Novelty (BERT): 0.6577981698708107
- Combined Prediction Score: 0.5976197289889884
- Mean Citation Score: 309.454316
- Max Citation Score: 673.39233
- Similarity Product: 614.5544041591287

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test