PATENT CLAIM ANALYSIS

Application Number: 15771043
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-02
Patent Classification: ["514", "021300"]

Abstract:
The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

Claim (Index 1):
A chemically modified polypeptide, or a salt or solvate thereof, wherein the polypeptide has at least one of the following chemical modifications:\n (i) at least one selected from the group consisting of an N-terminus amino group, the NH of the N-terminus first internal amide bond, other free primary amino group, thiol group and thioether group of the polypeptide is independently derivatized with optionally substituted C 1 -C 16  alkyl, optionally substituted C 3 -C 16  cycloalkyl, optionally substituted C 3 -C 16  aryl, optionally substituted C 2 -C 16  alkenyl or optionally substituted C 2 -C 16  alkynyl; and (ii) the NH group of at least one selected from the group consisting of the N-terminus amino group and the N-terminus first internal amide bond is derivatized with X, wherein each X is independently selected from the group consisting of optionally substituted phenyl, optionally substituted benzyl, optionally substituted \u2014(CR 2 ) 1-6 -phenyl, \u2192O, \u2014OH, \u2014OR, alkoxy, NH 2 , optionally substituted NH(C 1 -C 16  alkyl) and optionally substituted N(C 1 -C 16  alkyl)(C 1 -C 16  alkyl), where R is independently selected at each occurrence from hydrogen or optionally substituted C 1 -C 16  alkyl; wherein the chemically modified polypeptide has essentially the same biological activity and/or is more resistant to proteolytic degradation, as compared to the corresponding non-chemically modified polypeptide.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 91.0
- Lexical Diversity: 1.59524
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12845455', '13130962', '14182706', '13697021', '12066324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7938472773722655
- 35 USC 102 Novelty (BERT): 0.5065628790994338
- Combined Prediction Score: 0.7651188375449823
- Mean Citation Score: 258.376928
- Max Citation Score: 264.86304
- Similarity Product: 181.36385118896484

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test