PATENT CLAIM ANALYSIS

Application Number: 16065397
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "387000"]

Abstract:
Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

Claim (Index 73):
A compound that is\n 2-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol 7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol 7-(5H-imidazo[4,3-a]isoindol-5-yl)-5H,6H,7H,8H-imidazo[1,5-a]pyridin-8-ol 6-(5H-imidazo[4,3-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-5-ol 1-(3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)ethan-1-one tert-butyl 3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate tert-butyl 4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate 1-(4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)ethan-1-one 2-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol 2-(4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile 1-(ethylsulfonyl)-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol 1-(ethylsulfonyl)-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-1-ol 4,4-difluoro-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)-2,3-dihydro-1H-inden-1-ol 2-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclobutan-1-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclopentan-1-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol 2-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol 2-(3-hydroxy-4-(\u22125H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile 3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)pyrrolidine-1-sulfonamide 9-hydroxy-8-(5H-imidazo[5,1-a]isoindol-5-yl)-6,7,8,9-tetrahydro-4H-quinolizin-4-one 4-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-amine 4-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-3-ol 3-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-tetrahydro-2H-pyran-4-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-methylcyclobutan-1-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)-6-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)bicyclo[2.2.2]octan-2-ol 3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrothiophene 1,1-dioxide 3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-sulfonamide 1-(ethylsulfonyl)-4-(5H-imidazo[5,1-a]isoindol-5-yl)pyrrolidin-3-ol tert-butyl 7-hydroxy-6-(5H-imidazo[1,5-b]isoindol-5-yl)-2-azaspiro[3.3]heptane-2-carboxylate 1-(5H-imidazo[5,1-a]isoindol-5-yl)ethan-1-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)propan-2-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)thietan-3-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)oxetan-3-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)ethane-1,2-diol 3,3-difluoro-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methylpropan-1-ol cyclopropyl(5H-imidazo[5,1-a]isoindol-5-yl)methanol 4,4-difluoro-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol 3,3-bis(fluoromethyl)-1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)cyclopentan-1-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol 2-(4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-1-yl)acetonitrile 6-(5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol 5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide 3-(5H-imidazo[5,1-a]isoindol-5-yl)-4-methyltetrahydro-2H-pyran-4-ol 5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethyltetrahydro-2H-pyran-4-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)spiro[3.3]heptan-2-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)-8-oxaspiro[4.5]decan-1-ol 4-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol 3-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol 1-(cyclopropylsulfonyl)-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-4-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)spiro[2.3]hexan-5-ol 3-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol 3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)-N-methylpiperidine-1-sulfonamide 3-(7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol 4-(7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol 8-(ethylsulfonyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol 1-(cyclopropylsulfonyl)-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol 3-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethylpiperidine-1-sulfonamide 4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(isopropylsulfonyl)piperidin-3-ol 1-(cyclopropylsulfonyl)-4-(5H-imidazo[5,1-a]isoindol-5-yl)piperidin-3-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(2,2,2-trifluoroethyl)piperidin-3-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-methylpiperidin-3-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2,5,5-tetramethyltetrahydrofuran-3-ol 4-(5H-Imidazo[5,1-a]isoindol-5-yl)-2,2-dimethyltetrahydro furan-3-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)oxepan-4-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-2-oxaspiro[3.3]heptan-6-ol 7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(isopropylsulfonyl)piperidin-3-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)-2,6,6-trimethylcyclohexan-1-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)chroman-4-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)azepan-4-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinazolin-5-ol 2-(fluoromethyl)-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol 4-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)thiochromane 1,1-dioxide 5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide 5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-N,N-dimethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide 4-(9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol 5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide 4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)azepane-1-sulfonamide 2-(5H-imidazo[5,1-a]isoindol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol 4-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(oxetan-3-yl)piperidin-3-ol 5-hydroxy-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro quinoline-2-carboxamide 8-hydroxy-7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide 2,2-difluoro-6-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexan-1-ol 8-hydroxy-7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile 3-((5H-imidazo[5,1-a]isoindol-5-yl)methyl)-1-(ethylsulfonyl)azetidin-3-ol 2-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-7-oxaspiro[3.5]nonan-1-ol 4-(7-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol 2-amino-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro quinazolin-5-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydrophthalazin-5-ol 8-hydroxy-7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 7-(ethylsulfonyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)-7-azaspiro[3.5]nonan-1-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)cycloheptan-1-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)pyrrolidin-3-ol 7-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol 3-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-4-ol 4-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol 4-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol 2-amino-6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro quinolin-5-ol 8-hydroxy-7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide 6-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinoxalin-5-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-5,6,7,8-tetrahydroquinazolin-5-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-4-ol 7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-8-ol tert-Butyl 3-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)piperidine-1-carboxylate 1-(5H-imidazo[5,1-a]isoindol-5-yl)cycloheptan-1-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(tetrahydro-2H-pyran-4-yl)ethan-1-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)-4,4-dimethylcyclohexan-1-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(methylsulfonyl)piperidin-3-ol 1-(8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-2-methylpropan-1-ol 7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroindolizin-8-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)propan-1-ol (5H-imidazo[5,1-a]isoindol-5-yl)(tetrahydro-2H-pyran-4-yl)methanol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridin-4-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazol-7-ol 4-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carboxamide 8-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroisoquinolin-8-ol 2-(5H-imidazo[5,1-a]isoindol-5-yl)-7-(methylsulfonyl)-1,2,3,4-tetrahydronaphthalen-1-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(1H-imidazol-2-yl)ethan-1-ol 3-(5H-Imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-3-ol 4-hydroxy-4-(5H-imidazo[5,1-a]isoindol-5-yl)cyclohexane-1-carbonitrile 5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridin-4-ol 7-(5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)-3,3-dimethylcyclobutan-1-ol cyclohexyl(5H-imidazo[5,1-a]isoindol-5-yl)methanol 4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide 3,3-bis(fluoromethyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutan-1-ol 3-fluoro-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol (5H-imidazo[5,1-a]isoindol-5-yl)(pyridin-4-yl)methanol 1-(hydroxy(5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carbonitrile (1-fluorocyclopropyl)(5H-imidazo[5,1-a]isoindol-5-yl)methanol 3-hydroxy-3-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylpropanamide 4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carbonitrile 6-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydro-1H-indazol-7-ol 3-(5H-imidazo[5,1-a]isoindol-5-yl)cyclobutane-1,2-diol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol 3-chloro-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol 2-amino-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol 4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2-carboxamide 5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[c][1,2,5]oxadiazol-4-ol 1-(5H-imidazo[5,1-a]isoindol-5-yl)-2,2-dimethylcyclohexan-1-ol 1-(hydroxy(5H-imidazo[5,1-a]isoindol-5-yl)methyl)cyclopropane-1-carboxamide 5-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol 5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]oxazol-4-ol 8-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-5,6,7,8-tetrahydroquinolin-5-ol 3-(9-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydro-2H-pyran-4-ol 4-(8-methyl-5H-imidazo[5,1-a]isoindol-5-yl)tetrahydrofuran-3-ol 4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide 2-(difluoromethyl)-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol 4-hydroxy-5-(5H-imidazo[5,1-a]isoindol-5-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carbonitrile 7-(5H-imidazo[5,1-a]isoindol-5-yl)-3-methyl-5,6,7,8-tetrahydroisoquinolin-8-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazol-7-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-3-(methylsulfonyl)-3-azabicyclo[3.1.1]heptan-6-ol 5-(5H-imidazo[5,1-a]isoindol-5-yl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]oxazol-4-ol 8-(methylsulfonyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol 8-(methylsulfonyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol 1-hydroxy-2-(5H-imidazo[4,3-a]isoindol-5-yl)-7-azaspiro[3.5]nonane-7-sulfonamide 8-(methylsulfonyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)-8-azaspiro[4.5]decan-1-ol 6-(5H-imidazo[5,1-a]isoindol-5-yl)-2-(methylsulfonyl)-2-azaspiro[3.3]heptan-5-ol or a pharmaceutically acceptable salt thereof, or an enantiomer or diastereoisomer thereof, or a racemic mixture thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 94.0
- Lexical Diversity: 1.34783
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12666423', '15122863', '14061616', '16472185', '13897927']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8188353604538801
- 35 USC 102 Novelty (BERT): 0.534750186817396
- Combined Prediction Score: 0.7904268430902317
- Mean Citation Score: 367.118278
- Max Citation Score: 369.48654
- Similarity Product: 235.98519805053948

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test