PATENT CLAIM ANALYSIS

Application Number: 15952040
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["435", "007400"]

Abstract:
Disclosed herein are methods that aid in the hyperacute diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed here are methods that aid in the hyperacute determination of whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels of early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP), or a combination thereof, in samples taken from a human subject at a time point within about 2 hours, such as about 10, 12, or 20 minutes, after the subject has sustained or may have sustained an injury to the head.

Claim (Index 43):
The method of  claim 1 , wherein the sample is a plasma sample.

Metadata:
- Claim Count in Document: 128.0
- Percentile: 91.0
- Lexical Diversity: 2.2907
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15802489', '12822560', '12950142', '11107248', '15340002']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6404096433275671
- 35 USC 102 Novelty (BERT): 0.5489535120857014
- Combined Prediction Score: 0.6312640302033805
- Mean Citation Score: 382.777822
- Max Citation Score: 417.59793
- Similarity Product: 271.07464183142065

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test