PATENT CLAIM ANALYSIS

Application Number: 15752498
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "007210"]

Abstract:
Provided are a biomarker for evaluating a cerebral Aβ accumulation state using amyloid precursor protein (APP)-derived Aβ and Aβ-like peptides in a living body-derived sample as an index, and a method for analysis thereof. A marker for determining a cerebral Aβ accumulation state, the marker comprising a combination of at least two ratios selected from the group consisting of: a ratio of Aβ1-39 (SEQ ID NO.: 1) level to Aβ1-42 (SEQ ID NO.: 3) level: Aβ1-39/Aβ1-42; a ratio of Aβ1-40 (SEQ ID NO.: 2) level to Aβ1-42 (SEQ ID NO.: 3) level: Aβ1-40/Aβ1-42; and a ratio of APP669-711 (SEQ ID NO.: 4) level to Aβ1-42 (SEQ ID NO.: 3) level: APP669-711/Aβ1-42, in a living body-derived sample.

Claim (Index 2):
An analytical method for determining a cerebral A\u03b2 accumulation state, the method comprising:\n a measurement step of subjecting a living body-derived sample derived from a test subject to detection of a marker containing:\n A\u03b21-42 (SEQ ID NO.: 3); \n A\u03b21-39 (SEQ ID NO.: 1); and \n at least one selected from the group consisting of A\u03b21-40 (SEQ ID NO.: 2), and APP669-711 (SEQ ID NO.: 4), \n \n to obtain measurement levels of:\n A\u03b21-42; \n A\u03b21-39; and \n the at least one selected from the group consisting of A\u03b21-40, and APP669-711, in the living body-derived sample; \n a calculation step of calculating:\n a ratio of A\u03b21-39 level to A\u03b21-42 level: A\u03b21-39/A\u03b21-42; and \n at least one ratio selected from the group consisting of:\n a ratio of A\u03b21-40 level to A\u03b21-42 level: A\u03b21-40/A\u03b21-42; and \n a ratio of APP669-711 level to A\u03b21-42 level: APP669-711/A\u03b21-42; \n \n \n a derivation step of deriving a composite variable by a combination of each of the ratios calculated, through a mathematical technique; and \n an evaluation step of determining that an amount of cerebral A\u03b2 accumulation of the test subject is larger than an amount of cerebral A\u03b2 accumulation of a person who is negative for cerebral A\u03b2 accumulation, when the composite variable of the test subject is higher than a standard level which is the composite variable of the person who is negative for cerebral A\u03b2 accumulation.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 88.0
- Lexical Diversity: 2.29851
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13874052', '13744223', '14435520', '12812712', '14559301']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5871606509554929
- 35 USC 102 Novelty (BERT): 0.5076916204796349
- Combined Prediction Score: 0.579213747907907
- Mean Citation Score: 259.427202
- Max Citation Score: 267.0504
- Similarity Product: 171.0715062093258

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test