PATENT CLAIM ANALYSIS

Application Number: 15865574
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "093210"]

Abstract:
The technology described herein relates to methods and kits for directed differentation of primordial NKX2-1+ lung progenitors along proximal differentiation pathways into functional airway epithelial cells and airway organoids (“bronchospheres”) or along distal lineage pathways using modulation of Wnt signaling. Other aspects relate cell lines, methods, assays and kits comprising airway epithelial cells, and assays for diagnosing a disease that affects swelling of the bronchospheres, and/or for assessing genetic lesions and/or drugs for treating the the disease, where the disease is cystic fibrosis. Other aspects relate to personalized medicine and methods of treatment of cystic fibrosis using the airway epithelial cells.

Claim (Index 19):
A method of treating cystic fibrosis, comprising:\n a. differentiating a population of human iPSC or ESCs into NKX2-1 lung epithelial progenitor cells, b. culturing the NKX2-1 lung epithelial progenitor cells with a low-wnt media according to the methods as disclosed in claims to 1 to 24, to differentiate into airway epithelial cells expressing any of: NKX2-1+/SOX2+ cells, NKX2-1+/P63+ cells or NKX2-1+/P63+/K5 cells; c. administering the airway epithelial cells obtained in step (b) to the subject.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 86.0
- Lexical Diversity: 1.66176
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15635975', '14371627', '14367061', '15223603', '14417273']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7693438858725125
- 35 USC 102 Novelty (BERT): 0.5327262921120939
- Combined Prediction Score: 0.7456821264964706
- Mean Citation Score: 358.088658
- Max Citation Score: 371.3459
- Similarity Product: 264.9839052005053

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test