PATENT CLAIM ANALYSIS

Application Number: 16051612
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-06
Patent Classification: ["514", "262100"]

Abstract:
The present invention provides 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Claim (Index 12):
The compound or tautomer or pharmaceutically acceptable salt thereof of  claim 1 , wherein the compound is selected from the group consisting of:\n 6-benzyl-5-(cyclohexylmethyl)-1-tetrahydropyran-4-yl-pyrazolo[3, 4-d]pyrimidin-4-one; 5-(4-methoxybenzyl)-6-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3, 4-d]pyrimidin-4(5H)-one; 5-(cyclohexylmethyl)-6-methyl-1-tetrahydropyran-4-yl-pyrazolo[3, 4-d]pyrimidin-4-one; 5-[(4-methoxyphenyl)methyl]-6-methyl-1-propyl-pyrazolo[3, 4-d]pyrimidin-4-one; 5-(cyclohexylmethyl)-6-methyl-1-propyl-pyrazolo[3, 4-d]pyrimidin-4-one; 6-ethyl-5-[(4-methoxyphenyl)methyl]-1-tetrahydropyran-4-yl-pyrazolo[3, 4-d]pyrimidin-4-one; 6-(methoxymethyl)-5-[(4-methoxyphenyl)methyl]-1-tetrahydropyran-4-yl-pyrazolo[3, 4-d]pyrimidin-4-one; 6-isopropyl-5-[(4-methoxyphenyl)methyl]-1-tetrahydropyran-4-yl-pyrazolo[3, 4-d]pyrimidin-4-one; 5-[(4-methoxyphenyl)methyl]-6-(oxetan-3-ylmethyl)-1-tetrahydropyran-4-yl-pyrazolo[3, 4-d]pyrimidin-4-one; 5-[(3-fluorophenyl)methyl]-6-methyl-1-tetrahydropyran-4-yl-pyrazolo[4, 3-c]pyridin-4-one; 5-[(2-fluorophenyl)methyl]-6-methyl-1-tetrahydropyran-4-yl-pyrazolo[4, 3-c]pyridin-4-one; 5-[(4-chlorophenyl)methyl]-6-methyl-1-tetrahydropyran-4-yl-pyrazolo[4, 3-c]pyridin-4-one; 5-benzyl-6-methyl-1-tetrahydropyran-4-yl-pyrazolo[4,3-c]pyridin-4-one; 5-[(3-chlorophenyl)methyl]-6-methyl-1-tetrahydropyran-4-yl-pyrazolo[4, 3-c]pyridin-4-one; 5-[(4-fluorophenyl)methyl]-6-methyl-1-tetrahydropyran-4-yl-pyrazolo[4, 3-c]pyridin-4-one; 6-methyl-5-(p-tolylmethyl)-1-tetrahydropyran-4-yl-pyrazolo[4, 3-c]pyridin-4-one; 5-(1, 3-benzodioxol-5-ylmethyl)-6-methyl-1-tetrahydropyran-4-yl-pyrazolo[4, 3-c]pyridin-4-one; 5-[(6-methoxy-3-pyridyl)methyl]-6-methyl-1-tetrahydropyran-4-yl-pyrazolo[4, 3-c]pyridin-4-one; 5-(4-methoxybenzyl)-6-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[4, 3-c]pyridin-4-one; 5-(4-methoxybenzyl)-6-methyl-1-propyl-1, 5-dihydro-4H-pyrazolo[4, 3-c]pyridin-4-one; 1-isopropyl-5-[(4-methoxyphenyl)methyl]-6-methyl-pyrazolo[4, 3-c]pyridin-4-one; 5-[(4-methoxyphenyl)methyl]-6-methyl-1-tetrahydrofuran-3-yl-pyrazolo[4,3-c]pyridin-4-one; 1-cyclopropyl-5-[(4-methoxyphenyl)methyl]-6-methyl-pyrazolo[4, 3-c]pyridin-4-one; 1-ethyl-5-[(4-methoxyphenyl)methyl]-6-methyl-pyrazolo[4, 3-c]pyridin-4-one; 5-[(4-methoxyphenyl)methyl]-6-methyl-1-tetrahydropyran-3-yl-pyrazolo[4, 3-c]pyridin-4-one; 5-[(4-methoxyphenyl)methyl]-6-methyl-1-[(2S,3R)-2-methyltetrahydrofuran-3-yl]pyrazolo[4, 3-c]pyridin-4-one; 5-[(4-methoxyphenyl)methyl]-6-methyl-1-[(2R,3R)-2-methyltetrahydrofuran-3-yl]pyrazolo[4, 3-c]pyridin-4-one; 5-[(4-methoxyphenyl)methyl]-6-methyl-1-(oxetan-3-yl) pyrazolo[4, 3-c]pyridin-4-one; and 5-(4-methoxybenzyl)-6-methyl-1-(4-methyltetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[4, 3-c]pyridin-4-one.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 96.0
- Lexical Diversity: 1.23529
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16340429', '15637920', '16033395', '15849798', '15502144']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8474604929682001
- 35 USC 102 Novelty (BERT): 0.5851529249392308
- Combined Prediction Score: 0.8212297361653033
- Mean Citation Score: 404.623846
- Max Citation Score: 509.92545
- Similarity Product: 433.6794921207905

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test