PATENT CLAIM ANALYSIS

Application Number: 16175895
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "318000"]

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

Claim (Index 7):
The compound according to  claim 1 :\n R 1  is cyclopropyl; E 1 , E 2  and E 3  together form a moiety selected from L 1  is a covalent bond, Z is benzo[d]thiazolyl, isoquinolinyl, phenyl, pyrazolyl, pyridinyl, or quinolinyl, each substituted with zero to 3 R 10 ; R x  is \u2014C(O)OH, \u2014C(O)NH 2 , \u2014C(O)NHS(O) 2 CH 3 , \u2014CH 2 C(O)OH, or \u2014C(O)OCH 3 ; each R 10  is independently F, Cl, \u2014CH 3 , \u2014CH 2 CH 3 , \u2014CF 3 , \u2014OCH 3 , \u2014OCH 2 CH 3 , \u2014OCH(CH 3 ) 2 , \u2014OCHF 2 , \u2014OCF 3 , \u2014O(C 3-5  cycloalkyl), or cyclopropyl; L 2  is covalent bond; R 2  is phenyl or pyridinyl, each independently substituted with 0 to 3 R 16 ; and each R 16  is independently F, Cl, \u2014CH 3 , \u2014CF 3 , \u2014OCH 3 , or \u2014OCF 3 .

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14971875', '15541018', '14971825', '16322945', '12377307']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8047986592803844
- 35 USC 102 Novelty (BERT): 0.5327893889827504
- Combined Prediction Score: 0.777597732250621
- Mean Citation Score: 329.48176399999994
- Max Citation Score: 338.1815
- Similarity Product: 274.16349993798144

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test