PATENT CLAIM ANALYSIS

Application Number: 16148749
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["514", "001000"]

Abstract:
The present disclosure provides methods of treating fibrosis or a fibrotic disease or condition in a subject in need thereof comprising administering to the subject a therapeutically effective amount of cenicriviroc or a salt or solvent thereof. The fibrosis or fibrotic disease may be liver fibrosis, renal fibrosis, non-cirrhotic hepatic fibrosis, associated with non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), or emerging cirrhosis.

Claim (Index 24):
A method of treatment efficacy of fibrosis or a fibrotic disease or condition in a subject suffering from said disease or condition, the method comprising:\n (a) obtaining a first biological sample from said subject; (b) measuring a level or levels of one or more biological molecules in the first biological sample; and, (c) comparing the level or levels obtained from the first biological sample to a level or levels of biological molecules from a predetermined standard in a healthy subject; wherein the relative increase in level or levels of the biological molecules is indicative of treatment efficacy; wherein the biological molecule is selected from the group consisting of lipopolysaccharide (LPS), LPs-binding protein (LBP), 16S rDNA, sCD14, intestinal fatty acid binding protein (I-FABP), zonulin-1, Collagen 1a1 and 3a1, TGF-\u03b2, fibronectin-1, hs-CRP, IL-1\u03b2, IL-6, IL-33, fibrinogen, MCP-1, MIP-1\u03b1 and \u22121\u03b2, RANTES, sCD163, TGF-\u03b2, TNF-\u03b1, a biomarker of hepatocyte apoptosis, and a combination thereof.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 97.0
- Lexical Diversity: 1.63043
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15612124', '15979881', '15460917', '16133322', '16006615']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6714668080777266
- 35 USC 102 Novelty (BERT): 0.528074683859628
- Combined Prediction Score: 0.6571275956559168
- Mean Citation Score: 275.954396
- Max Citation Score: 321.28372
- Similarity Product: 228.8476944329977

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test