PATENT CLAIM ANALYSIS

Application Number: 16431674
Application Type: Utility
Filing Date: 2019-06
Publication Date: 2019-12
Patent Classification: ["435", "007210"]

Abstract:
Provided are methods of determining the aging of skin or skin disorders or conditions by measuring and evaluating levels of skin-associated biomarker proteins in a subject's skin sample. In aspects, the levels of a subset of biomarker proteins are altered, e.g., increased or decreased, in aging/aged versus non-aging/young skin. Provided are methods for more individualized and direct treatments and therapeutic options for aging skin and/or skin disorders and conditions by determining the levels of those skin biomarker proteins that correlate with aging skin and/or certain skin attributes of a subject and administering treatment products and regimens that result in altering the levels of the biomarker proteins, in particular, toward levels of the proteins in non-aged and healthy skin.

Claim (Index 12):
The kit of  claim 10 , comprising reagents for analyzing and/or quantifying the levels of a subset of biomarker proteins selected from the group consisting of GLUD1, DDX3X, ERGIC1, NIT2, PSMC5, TSG101, UQCRFS1, ZG16B, RAB1A, PLA2G4E, GPD2, AADAC, ATP6V1B2, PHB, NAPRT, RAB1B, SULT2B1, CARS, HSPA9, ACTR2, EIF2S1, RPL22, CAP1, ATP6V1E1, RTN3, DYNLL2, PHB2, ITPA, IST1, UQCRC2, FASN, LMNB2, MYO18A, ATP6V1A, ACOX1, RPN2, RAB7A, EIF4A1, ALDH2, ACTR3, ACADVL, KRT73, ANXA5, HNRNPH2, VCP, MYH14, ANXA4, PDCD6, HSPE1, IDE, CKAP4, PIP, CAPZ\u03b2, ASPRV1, MT-CO2, CAPG, RAB14, PTGS1, POF1B, HSPA5; TGM5, HSPA8, LGALS7B, HSPD1, CALML5, HPSE, TMED9, ACPP, FUCA1, HEBP2, S100A11, RPS27A, IL1RN, CKMT1B and CTSD.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 100.0
- Lexical Diversity: 2.13333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15013833', '14356029', '15287162', '12282840', '14569127']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5547878104447509
- 35 USC 102 Novelty (BERT): 0.4911655799271855
- Combined Prediction Score: 0.5484255873929944
- Mean Citation Score: 193.233828
- Max Citation Score: 197.38016
- Similarity Product: 129.16566905277253

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test