PATENT CLAIM ANALYSIS

Application Number: 15746357
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "401000"]

Abstract:
A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.

Claim (Index 52):
A method for manufacturing a negatively charged supported lipid bilayer on a positively charged mesoporous silica nanoparticle, said method comprising the following steps\n a) preparing a formulation of lipids, the lipids being 1,2-dioleoyl-sn-glycero-3-phospho-L-serine alias DOPS, cholesterol and at least one lipid different from DOPS and cholesterol, the formulation of lipids being dissolved in a first solvent; b) evaporating the first solvent; c) adding an aqueous formulation of positively charged mesoporous silica nanoparticles; and d) performing a centrifugation; wherein, the method further comprises the step of performing an ultra-sonication after step (c) and before step (d), and in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 86.0
- Lexical Diversity: 2.09677
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15746298', '15798287', '12909572', '14113371', '15304127']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6920833542333995
- 35 USC 102 Novelty (BERT): 0.5799091029116286
- Combined Prediction Score: 0.6808659291012225
- Mean Citation Score: 348.739548
- Max Citation Score: 512.3136
- Similarity Product: 367.6606622200012

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test