PATENT CLAIM ANALYSIS

Application Number: 16077475
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["544", "373000"]

Abstract:
The present solution relates to crystalline modifications of methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate salts of Formula I, wherein HX represents at least one acid component, preferably methanesulfonic acid, p-toluenesulphonic acid, L-tartaric acid, maleic acid, acetic acid and phosphoric acid. Another solution also relates to the processes for the preparation thereof as well as said use thereof in pharmaceutically acceptable compositions. Use of said crystalline forms of intedanib and manufactured salts in the preparation of methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate in the form of any pharmaceutically acceptable salt thereof is also object of this invention.

Claim (Index 10):
The process according to  claim 8 , wherein the polar protic solvent is selected from the group consisting of methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol or a mixture thereof.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 96.0
- Lexical Diversity: 2.12676
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13637048', '10599461', '13143831', '14363146', '10749932']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7752057887962458
- 35 USC 102 Novelty (BERT): 0.5096560372867499
- Combined Prediction Score: 0.7486508136452962
- Mean Citation Score: 243.706926
- Max Citation Score: 259.8002
- Similarity Product: 172.084020110786

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test