PATENT CLAIM ANALYSIS

Application Number: 15749168
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["435", "325000"]

Abstract:
CRISPR/Cas Systems are provided where two or more guide RNAs having different spacer sequence lengths direct an enzymatically active Cas9 having a transcriptional regulator attached thereto to either cut a target nucleic acid or regulate expression of a target nucleic acid.

Claim (Index 16):
A method of modulating expression of a first target nucleic acid in a cell and altering expression of second target nucleic acid in the cell comprising\n providing to the cell an enzymatically active Cas9 having a transcriptional regulator attached thereto, providing to the cell a first guide RNA having a spacer sequence of 14 to 8 nucleotides, providing to the cell a second guide RNA having a spacer sequence of 25 to 15 nucleotides, wherein the first guide RNA and the enzymatically active Cas9 having a transcriptional regulator attached thereto form a co-localization complex with the first target nucleic acid and wherein the transcriptional regulator regulates expression of the target nucleic acid, and wherein the second guide RNA and the enzymatically active Cas9 having a transcriptional regulator attached thereto form a co-localization complex with the second target nucleic acid and wherein the enzymatically active Cas9 cleaves the second target nucleic acid in a site specific manner.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 1.2
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14319289', '15049451', '14674895', '14903728', '14105017']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6929468507640355
- 35 USC 102 Novelty (BERT): 0.5798725685656934
- Combined Prediction Score: 0.6816394225442013
- Mean Citation Score: 478.90802600000006
- Max Citation Score: 500.33353
- Similarity Product: 440.1437369141484

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test