PATENT CLAIM ANALYSIS

Application Number: 15918626
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "04400A"]

Abstract:
The subject invention pertains to biomarkers for identifying BC in a subject. The biomarkers presented herein include miRNAs, particularly, a combination of miRNAs. The invention demonstrates that the specific miRNAs are increased body fluid, particularly, urine, from a subject compared to that of a control. Accordingly, the levels of specific mRNAs, in a body fluid, particularly, urine, from a subject is used to diagnose BC in a subject. The invention also provides kits and reagents to conduct assays to quantify biomarkers described herein. The invention further provides methods of treating and/or managing BC in a subject.

Claim (Index 1):
A method for treating bladder cancer (BC) in a subject, the method comprising the steps of:\n (a) determining the level of two or more microRNAs (miRNAs) in:\n i) a test sample obtained from the subject, and \n ii) optionally a control sample; \n (b) optionally obtaining two or more reference values corresponding to levels of one or miRNAs, and (c) identifying the subject as having BC based on the level of two or more miRNAs in the test sample and optionally, administering a therapy to the subject to treat BC, or (d) identifying the subject as not having BC based on the level of two or more miRNAs in the test sample and withholding the therapy to the subject to treat BC; wherein the two or more miRNAs are selected from the miRNAs in Panel 25.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 90.0
- Lexical Diversity: 2.15385
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15300808', '13746589', '14755261', '15852128', '15318646']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6131418735966171
- 35 USC 102 Novelty (BERT): 0.5019447668419336
- Combined Prediction Score: 0.6020221629211489
- Mean Citation Score: 209.242642
- Max Citation Score: 225.11575
- Similarity Product: 149.69188828633725

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test