PATENT CLAIM ANALYSIS

Application Number: 16063535
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["506", "016000"]

Abstract:
Disclosed herein are methods and compositions for the detection of small RNAs in a sample. The methods and compositions disclosed herein may be used for preparing sequencing libraries of the small RNAs, fragments of RNAs and DNAs.

Claim (Index 55):
A method for detecting a sample polynucleotide in a sample comprising:\n a) ligating a combo adapter to the sample polynucleotide to produce an adapter-polynucleotide ligation product, wherein said combo adapter comprises a 5\u2032-proximal segment and a 3\u2032-proximal segment, and wherein at least one of the 5\u2032 proximal segment or 3\u2032 proximal segment comprises a sequencing adapter; b) circularizing said adapter-polynucleotide ligation product by ligating its 5\u2032 end to its 3\u2032 end to produce a circularized adapter-polynucleotide ligation product; c) hybridizing a first primer comprising a sequence at least partially complementary to the 5\u2032-proximal segment of said combo adapter, to said circularized adapter-polynucleotide ligation product; d) extending said first primer with a polymerase to produce a monomeric nucleic acid that is complementary to the sample polynucleotide flanked by the sequencing adapter; e) amplifying said monomeric nucleic acid using said first primer and a second primer, wherein the sequence of the second primer is at least partially complementary to the 3\u2032-proximal segment of said combo adapter; f) detecting the amplified monomeric nucleic acid or portion thereof, thereby detecting the sample polynucleotide.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 94.0
- Lexical Diversity: 1.48148
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14835544', '15287254', '13264122', '14600550', '14367200']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6964764853921641
- 35 USC 102 Novelty (BERT): 0.6122307807182561
- Combined Prediction Score: 0.6880519149247734
- Mean Citation Score: 525.9268480000002
- Max Citation Score: 578.5201400000002
- Similarity Product: 505.2094061926796

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test