PATENT CLAIM ANALYSIS

Application Number: 15771476
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "415000"]

Abstract:
The invention relates to the use of Indoline derivatives, and their effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.

Claim (Index 1):
A method for prevention and/or treatment of a fibrosis disease in a subject, comprising administering an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt, solvate or prodrug as an active ingredient to the subject; wherein n is 0, 1, or 2; R 1  is SO 2 R a , in which R a  is alkenyl, alkynyl, phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; R 2  is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halo, cyano, nitro, OR b , SR b , S(O)R b , NHC(O)\u2014CH\u2550CH\u2014C(O)R b , NHC(O)\u2014CH\u2550CH\u2014C(O)NR c R d , SO 2 NR c R d , OC(O)R b , C(O)NR c R d , NR c R d , NHC(O)R b , NHC(O)NR c R d , or NHC(S)R c , in which each of R b , R c , and R d , independently, is H, hydroxy, alkoxy, aryloxy, heteroaryloxy, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; and each of R 3 , R 4 , R 5 , and R 6 , independently is, H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halo, cyano, nitro, OR b , SR b , S(O)R b , CH\u2550CH\u2014C(O)NR c R d , NHC(O)\u2014CH\u2550CH\u2014C(O)R b , NHC(O)\u2014CH\u2550CH\u2014C(O)NR c R d , SO 2 NR c R d , OC(O)R b , C(O)NR c R d , NR c R d , NHC(O)R b , NHC(O)NR c R d , or NHC(S)R c , in which each of R b , R c , and R d , independently, is H, hydroxy, alkoxy, aryloxy, heteroaryloxy, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl.

Metadata:
- Claim Count in Document: 31.0
- Percentile: 91.0
- Lexical Diversity: 1.1875
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15852977', '11238285', '15737125', '14448998', '14772334']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6778686215635862
- 35 USC 102 Novelty (BERT): 0.4973238746507096
- Combined Prediction Score: 0.6598141468722984
- Mean Citation Score: 210.18250200000003
- Max Citation Score: 220.74232
- Similarity Product: 161.15537085231782

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test