PATENT CLAIM ANALYSIS

Application Number: 15877619
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["435", "006100"]

Abstract:
The invention provides methods for detecting small mutations and structural alterations in DNA by using binding proteins to protect those features while digesting unprotected DNA in a sample. To detect small mutations, a protein that binds exclusively to the mutation of interest, and not to wild-type, is used. For structural alterations, binding proteins are used that flank a breakpoint of the alteration. After digestion of unbound, unprotected nucleic acid in the sample, the mutation- or breakpoint-containing segment remains as an isolated DNA fragment. The sample is then assayed to detect any fragment of DNA and the detection of the fragment indicates the presence of the mutation or breakpoint in the subject.

Claim (Index 16):
The method of  claim 14 , wherein the first Cas endonuclease/guide RNA complex includes a guide RNA with targeting region that binds to the mutation but that does not bind to other variants at a loci of the mutation.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.79412
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15877620', '14804068', '14836753', '14882763', '14607781']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5622918165597417
- 35 USC 102 Novelty (BERT): 0.5310225546850549
- Combined Prediction Score: 0.559164890372273
- Mean Citation Score: 249.44334
- Max Citation Score: 286.79733
- Similarity Product: 198.47500953593013

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test