PATENT CLAIM ANALYSIS

Application Number: 16248507
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["424", "172100"]

Abstract:
The instant disclosure provides antibodies that specifically bind to ApoC3 (e.g., human ApoC3) and antagonize ApoC3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Claim (Index 1):
An isolated antibody that specifically binds to ApoC3, the antibody comprising a heavy chain variable region comprising complementarity determining regions CDRH1, CDRH2 and CDRH3, and a light chain variable region comprising complementarity determining regions CDRL1, CDRL2 and CDRL3, wherein:\n (a) CDRH1 comprises the amino acid sequence of TYSMR (SEQ ID NO: 3); (b) CDRH2 comprises the amino acid sequence of SIHTX 1 X 2 GGTAYRDSVKG, wherein X 1  is G, E, or D, and X 2  is G or A (SEQ ID NO: 87); (c) CDRH3 comprises the amino acid sequence of AGYSD (SEQ ID NO: 10); (d) CDRL1 comprises the amino acid sequence of KTSQGLVHSXGKTYFY, wherein X is D or G (SEQ ID NO: 88); (e) CDRL2 comprises the amino acid sequence of QVSNRAS (SEQ ID NO: 7); and (f) CDRL3 comprises the amino acid sequence of AXGTYYPHT, wherein X is Q or H (SEQ ID NO: 8, and\n wherein the CDRH1, CDRH2, and CDRH3 of the antibody are not SEQ ID NOs: 3, 9, and 10; 3, 11, and 10; 3, 9, and 12; or 3, 11, and 12, respectively.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 99.0
- Lexical Diversity: 1.36585
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15606148', '15254315', '15166305', '16165833', '15524651']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7441965999903508
- 35 USC 102 Novelty (BERT): 0.5600999489779447
- Combined Prediction Score: 0.7257869348891102
- Mean Citation Score: 428.60382800000014
- Max Citation Score: 446.3738
- Similarity Product: 411.4746134065392

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test