PATENT CLAIM ANALYSIS

Application Number: 16237017
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-07
Patent Classification: ["514", "215000"]

Abstract:
Described herein are fused bicyclic compounds, compositions, and methods for their use for the treatment of disease.

Claim (Index 74):
A compound having the structure of Formula (IIa), or a pharmaceutically acceptable salt, solvate, or prodrug thereof: wherein: R 1  is selected from the group consisting of hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 2 -C 6 alkenyl, optionally substituted C 2 -C 6 alkynyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted aryl, optionally substituted \u2014(C 1 -C 2 alkylene)-(aryl), optionally substituted C 2 -C 9 heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted \u2014(C 1 -C 2 alkylene)-(heteroaryl); R 2  is selected from the group consisting of \u2014CN, \u2014C(O)OR 25 , \u2014C(O)N(R 25 )R 26 , or R 1  and R 2  together with the carbon atoms to which they are attached, form an optionally substituted C 2 -C 9 heterocycloalkyl ring or an optionally substituted heteroaryl ring;\n R 4  and R 5  are each independently selected from the group consisting of hydrogen, halogen, optionally substituted C 1 -C 6 alkoxy, optionally substituted C 1 -C 6 alkyl, optionally substituted C 2 -C 6 alkenyl, and optionally substituted C 2 -C 6 alkynyl; or R 4  and R 5  together with the carbon atom to which they are attached, form an optionally substituted C 3 -C 6 cycloalkyl ring or an optionally substituted C 2 -C 7 heterocycloalkyl ring; \n R 6  is selected from the group consisting of hydrogen, halogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 2 -C 6 alkenyl, optionally substituted C 2 -C 6 alkynyl, and \u2014C(O)N(R 27 )R 28 ; \n R 7  is selected from the group consisting of hydrogen, halogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 alkoxy, optionally substituted C 2 -C 6 alkenyl, and optionally substituted C 2 -C 6 alkynyl; \n R 8  is selected from the group consisting of hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted aryl, optionally substituted \u2014(C 1 -C 2 alkylene)-(aryl), optionally substituted heteroaryl, optionally substituted C 2 -C 9 heterocycloalkyl, and optionally substituted \u2014(C 1 -C 2 alkylene)-(heteroaryl); \n each R 11  is independently selected from the group consisting of halogen, \u2014CN, amino, alkylamino, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, C 3 -C 8 cycloalkyl, C 2 -C 9 heterocycloalkyl, aryl, heteroaryl, \u2014C(O)OR 12 , and \u2014C(O)N(R 13 )R 14 ; \n each R 12  is independently selected from the group consisting of hydrogen and C 1 -C 6 alkyl; \n each R 13  and R 14  are each independently selected from the group consisting of hydrogen and C 1 -C 6 alkyl; or R 13  and R 14  together with the nitrogen atom to which they are attached, form an optionally substituted C 2 -C 9 heterocycloalkyl ring; \n R 25  and R 26  are each independently selected from the group consisting of hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted aryl, optionally substituted \u2014(C 1 -C 2 alkylene)-(aryl), optionally substituted C 2 -C 9 heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted \u2014(C 1 -C 2 alkylene)-(heteroaryl); \n R 27  and R 28  are each independently selected from the group consisting of hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted aryl, optionally substituted \u2014(C 1 -C 2 alkylene)-(aryl), optionally substituted C 2 -C 9 heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted \u2014(C 1 -C 2 alkylene)-(heteroaryl); or R 27  and R 28  together with the nitrogen atom to which they are attached, form an optionally substituted C 2 -C 9 heterocycloalkyl ring; \n R 30  is halogen, \n each R 31  is independently halogen, \u2014OH, \u2014CN, \u2014NO 2 , \u2014NH 2 , optionally substituted C 1 -C 6 alkyl, optionally substituted C 1 -C 6 alkoxy, optionally substituted C 1 -C 6 alkylamine, optionally substituted C 3 -C 8 cycloalkyl, optionally substituted C 2 -C 9 heterocycloalkyl, aryl, or heteroaryl; each R 32  and R 33  are each independently selected from the group consisting of hydrogen, halogen, and C 1 -C 6 alkyl; R 34  and R 35  are each independently selected from the group consisting of hydrogen, optionally substituted C 1 -C 6 alkyl, optionally substituted C 3 -C 8 cycloalkyl, and optionally substituted C 2 -C 9 heterocycloalkyl; or R 34  and R 35  together with the nitrogen atom to which they are attached, form an optionally substituted C 2 -C 9 heterocycloalkyl ring; n is 0, 1, 2, or 3 p is 0, 1, 2, 3, or 4; r is 0, 1, 2, 3, or 4; and t is 2, 3, or 4.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 98.0
- Lexical Diversity: 1.11111
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15630189', '15599647', '15714013', '15024681', '15546165']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8025260338212676
- 35 USC 102 Novelty (BERT): 0.5914546155503715
- Combined Prediction Score: 0.7814188919941781
- Mean Citation Score: 385.994132
- Max Citation Score: 479.6023
- Similarity Product: 470.53142407994864

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test