PATENT CLAIM ANALYSIS

Application Number: 16216666
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["800", "006000"]

Abstract:
The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

Claim (Index 1):
A mouse having a genome comprising an IgH locus comprising one or more human variable heavy (VH) gene segments, one or more human joining heavy (JH) gene segments and one or more human D gene segments positioned at an endogenous IgH locus upstream of an enhancer and a constant (C) region comprising an endogenous IgH C gene segment, and one or more human JL gene segments and one or more human VL gene segments upstream of a constant gene segment at an endogenous light chain locus,\n wherein said IgH locus comprises in 5\u2032 to 3\u2032 transcriptional orientation said unrearranged human IgH and said unrearranged human IgH joining (JH) gene segments, a human/mouse chimeric DNA junction, an enhancer, and said C region, wherein said one or more unrearranged human IgH joining (JH) gene segments comprises a human JH gene segment closest to said chimeric DNA junction, wherein said closest human JH gene segment is less than 2 kb upstream of said chimeric DNA junction, wherein DNA between said closest human JH gene segment and said chimeric DNA junction comprises human DNA naturally contiguous with said closest human JH gene segment, wherein DNA between said chimeric DNA junction and said enhancer comprises mouse DNA of the mouse JC intron, wherein said mouse JC intronic DNA comprises less than the complete mouse JC intron, and said human DNA is contiguous with said mouse DNA at an internal position of the mouse JC intron, wherein said human gene segments in each said Ig locus are unrearranged and operably linked to the constant gene segment thereof so that the mouse is capable of producing an antibody heavy chain generated by recombination of a said one or more human JH gene segments with a said one or more D gene segments and a said one or more VH segments, and an antibody light chain generated by recombination of a said one or more human JL gene segments with a said one or more VL segments, wherein said one or more human VH gene segments of the heavy chain locus comprise one or more human VH gene segments selected from the group consisting of VH3-23*04, VH7-4-1*01, VH4-4*02, VH 1-3*01, VH3-13*01, VH3-7*01, VH3-20*d01 and VH3-9*01; and/or wherein said one or more human VL gene segments of the heavy chain locus comprise one or more human VK gene segments selected from the group consisting of VK4-1\u203301, VK2-28*01, VK1D-13*d01, VK1-12*01, VK1D-12*02, VK3-20*01, VK1-17*01, VK1 D-39*01, VK3-11*01, VK1 D-16*01 and VK1-9*d01.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 98.0
- Lexical Diversity: 1.61111
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15088805', '13846672', '15690183', '14935010', '13434361']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6863698062621998
- 35 USC 102 Novelty (BERT): 0.7519182287003365
- Combined Prediction Score: 0.6929246485060135
- Mean Citation Score: 877.5522199999997
- Max Citation Score: 1065.068
- Similarity Product: 887.0968381381035

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test