PATENT CLAIM ANALYSIS

Application Number: 15957376
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["424", "186100"]

Abstract:
This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the minicircle DNA vector includes: a eukaryotic translation initiation nucleotide sequence, a mutant nucleotide sequence that encodes a foot-and-mouth disease virus (FMDV) capsid polyprotein precursor that contains at least one mutation to eliminate a restriction enzyme recognition site, a nucleotide sequence that encodes a protease that cleaves the FMDV capsid polyprotein precursor into a plurality of FMDV capsid proteins and a translational regulatory element to regulate the expression of the protease. The minicircle DNA vectors can be transfected directly into the cell of a mammalian host. When transfected into the mammalian host cell, virus-like particles can be produced intrinsically to stimulate the mammalian host's immune system to develop adaptive immunity toward foot-and-mouth disease.

Claim (Index 5):
The mutant nucleotide sequence of  claim 1 , wherein the restriction enzyme recognition site is selected from the group consisting of XbaI, XcmI, BsiWI, XhoI, BstEII, PflMI, AccI, NheI, SacII, PpuMI, AgeI, PvuII, NcoI, PstI, BstXI, AatI, and combinations thereof.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 91.0
- Lexical Diversity: 1.79268
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14962272', '15259409', '15407982', '14863181', '13502014']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7745547906186565
- 35 USC 102 Novelty (BERT): 0.6399568236157112
- Combined Prediction Score: 0.761094993918362
- Mean Citation Score: 381.105392
- Max Citation Score: 751.46625
- Similarity Product: 545.3271140833943

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test