PATENT CLAIM ANALYSIS

Application Number: 16226070
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "210200"]

Abstract:
Provided are a pyrimidine compound represented by Formula 1, a method of preparing the same, and a pharmaceutical use of the pyrimidine compound for the prevention or treatment of cancer.

Claim (Index 8):
The compound of  claim 1 , wherein the compound of Formula 1 is selected from the group consisting of the following compounds:\n 1 2-(4-(3-((5-chloro-4-(6-fluoro-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperazine-1-yl)ethane-1-ol 2 2-(4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2yl)amino)-5-cyclopropyl(phenyl)piperazine-1-yl)ethane-1-ol 3 5-chloro-N-(3-cyclopropyl-5-(4-(dimethylamino)piperidine-1-yl)phenyl)-4-(1H-indole-3-yl)pyrimidine-2-amine 4 (S)-1-((1-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperidine-4-yl)(methyl)amino)propane-2-ol 5 (S)-1-((1-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperidine-4-yl)(methyl)amino)propane-2-ol 6 5-chloro-N-(3-cyclopropyl-5-(4-(dimethylamino)piperidine-1-yl)phenyl)-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine 7 2-(4-(3-((5-chloro-4-(6-methoxy-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperazine-1-yl)ethane-1-ol 8 (S)-1-(1-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperidine-4-yl)pyrrolidine-3-ol 9 (S)-1-(1-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperidine-4-yl)pyrrolidine-3-ol 10 5-chloro-N-(3-cyclopropyl-5-(4-(dimethylamino)piperidine-1-yl)phenyl)-4-(6-methoxy-1H-indole-3-yl)pyrimidine-2-amine 11 (S)-1-(1-(3-((5-chloro-4-(6-methoxy-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperidine-4-yl)pyrrolidine-3-ol 12 2-(4-(3-((4-(1H-indole-3-yl)-5-methylpyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperazine-1-yl)ethane-1-ol 13 5-chloro-N-(3-cyclopropyl-5-(4-morpholinopiperidine-1-yl)phenyl)-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine 14 5-chloro-N-(3-cyclopropyl-5-(4-(ethyl(methyl)amino)piperidine-1-yl)phenyl)-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine 15 5-chloro-N-(3-cyclopropyl-5-(4-(diethylamino)piperidine-1-yl)phenyl)-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine 16 5-chloro-N-(3-cyclopropyl-5-(3-(dimethylamino)pyrrolidine-1-yl)phenyl)-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine 17 2-(4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperazine-1-yl)-2-methylpropane-1-ol 18 N-(3-(4-aminopiperidine-1-yl)-5-cyclopropylphenyl)-5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine 19 5-chloro-N-(3-cyclopropyl-5-(4-(methylamino)piperidine-1-yl)phenyl)-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine 20 2-(4-(3-((5-chloro-4-(6-fluoro-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperazine-1-yl)-2-methylpropane-1-ol 21 2-(4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperidine-1-yl)ethane-1-ol 22 2-(4-(3-((5-chloro-4-(6-chloro-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperazine-1-yl)ethane-1-ol 23 5-chloro-N-(3-cyclopropyl-5-(4-(pyrrolidine-1-yl)piperidine-1-yl)phenyl)-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine 24 1-(1-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenyl)piperidine-4-yl)azetidine-3-ol 25 2-(4-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-methoxyphenyl)piperazine-1-yl)ethane-1-ol 26 2-(4-(3-((5-chloro-4-(6-fluoro-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)piperazine-1-yl)ethane-1-ol 27 2-(4-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)piperidine-1-yl)ethane-1-ol 28 2-(4-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl) piperazine-1-yl)ethane-1-ol 29 5-chloro-N-(3-(4-(dimethylamino)piperidine-1-yl)phenyl)-4-(1H-indole-3-yl)pyrimidine-2-amine 30 5-chloro-N-(3-(3-(dimethylamino)pyrrolidine-1-yl)phenyl)-4-(1H-indole-3-yl)pyrimidine-2-amine 31 2-(4-(3-((5-chloro-4-(6-fluoro-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-methoxyphenyl)piperazine-1-yl)ethane-1-ol 32 2-(4-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-isopropoxyphenyl)piperazine-1-yl)ethane-1-ol 33 2-(4-(3-((5-chloro-4-(6-fluoro-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-isopropoxyphenyl)piperazine-1-yl)ethane-1-ol 34 5-chloro-N-(3-cyclopropyl-5-(piperazine-1-ylmethyl)phenyl)-4-(6-fluoro-1H-indole-3-yl)pyrimidine-2-amine 35 2-(4-(3-((5-chloro-4-(6-fluoro-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-methoxybenzyl)piperazine-1-yl)ethane-1-ol 36 2-(4-(3-((5-chloro-4-(6-fluoro-1H-indole-3-yl)pyrimidine-2-yl)amino)benzyl)piperazine-1-yl)ethane-1-ol 37 2-(4-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-methoxybenzyl)piperazine-1-yl)ethane-1-ol 38 2-(4-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperazine-1-yl)-2-methylpropane-1-ol 39 (S)-1-((1-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperidine-4-yl)(methyl)amino)propane-2-ol 40 (S)-1-((1-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperidine-4-yl)(methyl)amino)propane-2-ol 41 2-(4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperazine-1-yl)-2-methylpropane-1-ol 42 (S)-1-(1-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperidine-4-yl)pyrrolidine-3-ol 43 (S)-1-(1-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperidine-4-yl)pyrrolidine-3-ol 44 (S)-1-(1-(3-((5-chloro-4-(6-methoxy-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperidine-4-yl)pyrrolidine-3-ol 45 1-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperidine-4-ol 46 (S)-5-chloro-N-(3-cyclopropyl-5-((3-(dimethylamino)pyrrolidine-1-yl)methyl)phenyl)-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine 47 1-(4-(3-((5-chloro-4-(6-fluoro-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperazine-1-yl)-2-hydroxyethane-1-one 48 1-(4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperazine-1-yl)-2-hydroxyethane-1-one 49 2-(4-(3-((5-chloro-4-(6-ethyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylbenzyl)piperazine-1-yl)ethane-1-ol 50 (3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-methoxyphenyl)(4-(2-hydroxyethyl)piperazine-1-yl)methanone 51 1-(2-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenoxy)ethyl)piperidine-4-ol 52 1-(2-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino-5-ethylphenoxy)ethyl)piperidine-4-ol 53 (R)-2-(3-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenoxy)pyrrolidine-1-yl)ethane-1-ol 54 2-(4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-5-cyclopropylphenoxy)piperidine-1-yl)ethane-1-ol 55 2-(4-(3-((5-chloro-4-(1H-indole-3-yl)pyrimidine-2-yl)amino)-5-methoxyphenoxy)piperidine-1-yl)ethane-1-ol

Metadata:
- Claim Count in Document: 23.0
- Percentile: 98.0
- Lexical Diversity: 1.375
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16127487', '15319151', '12843494', '15565897', '12002340']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8367524280004204
- 35 USC 102 Novelty (BERT): 0.5978864965287327
- Combined Prediction Score: 0.8128658348532516
- Mean Citation Score: 352.326112
- Max Citation Score: 527.59644
- Similarity Product: 472.7525260061646

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test