PATENT CLAIM ANALYSIS

Application Number: 16122416
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["514", "348000"]

Abstract:
Methods and compositions for use in treating, attenuating, preventing or improving liver fibrosis in a subject are described. The compounds of the present invention are gamma-ketoaldehyde scavengers.

Claim (Index 1):
A method for treating, preventing, or ameliorating liver fibrosis to a subject with or at risk of liver fibrosis, thereby inhibiting or treating the liver fibrosis, comprising the step of administering to the subject at least one compound in a dosage and amount effective to treat the dysfunction in the mammal, the compound having a structure represented by a compound of the following formula: wherein: R is N or C; R 2  is independently H, hydroxy, halogen, nitro, CF 3 , C 1-6  alkyl, C 1-6  alkoxy, C 3-10  cycloalkyl, C 3-8  membered ring containing C, O, S or N, optionally substituted with one or more R 2 , R 3  and R 4 , and may cyclize with to one or more R 2 , R 3 , or R 5  to form an optionally substituted C 3-8  membered ring containing C, O, S or N; R 3  is H, hydroxy, halogen, nitro, CF 3 , C 1-6  alkyl, C 1-6  alkoxy, C 3-10  cycloalkyl, C 3-8  membered ring containing C, O, S or N, optionally substituted with one or more R 4 , R 2  and R 3  may cyclize with to one or more R 2  or R 5  to form an optionally substituted C 3-8  membered ring containing C, O, S or N; R 4  is H, hydroxy, halogen, nitro, CF 3 , C 1-6  alkyl, C 1-6  alkoxy, C 3-10  cycloalkyl, C 3-8  membered ring containing C, O, S or N, optionally substituted with one or more R 4 , R 2  and R 3  may cyclize with to one or more R 2 , R 3 , or R 5  to form an optionally substituted C 3-8  membered ring containing C, O, S or N; R 5  is a bond, H, hydroxy, halogen, nitro, CF 3 , C 1-6  alkyl, C 1-6  alkoxy, C 3-10  cycloalkyl, C 3-8  membered ring containing C, O, S or N, optionally substituted with one or more R 4 , R 2  and R 3  may cyclize with to one or more R 2 , R 3 , or R 4  to form an optionally substituted C 3-8  membered ring containing C, O, S or N; and stereoisomers and analogs thereof; with a drug having a known side effect of treating, preventing, or ameliorating liver fibrosis.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 97.0
- Lexical Diversity: 1.14815
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12865668', '13523519', '13003514', '13386387', '11025373']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6863774566297625
- 35 USC 102 Novelty (BERT): 0.4932786690026216
- Combined Prediction Score: 0.6670675778670484
- Mean Citation Score: 242.45498000000003
- Max Citation Score: 247.73665
- Similarity Product: 197.41410933089853

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test