PATENT CLAIM ANALYSIS

Application Number: 15934837
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["436", "501000"]

Abstract:
The invention relates to methods for providing prognosis, diagnosis, monitoring and treatment of a mild traumatic brain injury (mTBI) in a subject, including a sports-related concussion. The invention further relates to assessing the severity of brain damage resulting from mTBI in a subject, including in a subject who has not undergone a CT scan following the injury. For example, the methods of the invention can be used to determine the suitability for someone who has suffered a sports-related injury to return to play that sport. This invention also relates to methods of predicting risk for developing brain damage and long-term dysfunction in a subject having suffered mTBI.

Claim (Index 25):
A method of monitoring a subject having suffered from a mild traumatic brain injury (mTBI), said method comprising:\n (a) obtaining a blood, serum, or plasma sample from said subject; (b) contacting said sample with an antibody that specifically binds to calpain-cleaved \u03b1II-spectrin N-terminal fragment (SNTF) to form an antibody-SNTF complex; (c) measuring the amount of the antibody-SNTF complex, to determine SNTF concentration in the subject's serum or plasma; (d) comparing the serum or plasma concentration of SNTF in the subject to that of a pre-determined standard; and (e) repeating steps (a)-(d) at a plurality of times in a subject having elevated level of SNTF relative to the standard, and wherein sustained elevated SNTF levels indicates a subsequent increased risk of long-term neurological dysfunction; wherein an initial sample is obtained from the subject within 36 hours of the injury.

Metadata:
- Claim Count in Document: 109.0
- Percentile: 90.0
- Lexical Diversity: 1.87302
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14537642', '15391755', '14871232', '15802489', '15570982']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6246401440582934
- 35 USC 102 Novelty (BERT): 0.6333091505837575
- Combined Prediction Score: 0.6255070447108398
- Mean Citation Score: 366.4781059999999
- Max Citation Score: 620.06616
- Similarity Product: 565.1839337302207

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test