PATENT CLAIM ANALYSIS

Application Number: 16100048
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2020-02
Patent Classification: ["null", "null"]

Abstract:
The invention relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets that are coated with a colon release coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption.

Claim (Index 1):
An oral dosage form comprising:\n a) a plurality of extruded and spheronized pellets, each extruded and spheronized pellet comprising cholestyramine and\n i. at least 7% w/w of a vinylpyrrolidone-based polymer; or \n ii. a combination of at least 6% w/w of a vinylpyrrolidone-based polymer and at least 2% w/w of an acrylate copolymer; or \n iii. a combination of at least 5% w/w of a vinylpyrrolidone-based polymer and at least 3% w/w of an acrylate copolymer; or \n iv. a combination of at least 6% w/w of a vinylpyrrolidone-based polymer, at least 1% w/w of an acrylate copolymer and at least 10% w/w microcrystalline cellulose; and \n b) a coating surrounding each extruded and spheronized pellet, wherein the coating is capable of targeting release of the cholestyramine in the colon; wherein the oral dosage form exhibits less than about 30% sequestration of cholic acid, chenodeoxycholic acid, and deoxycholic acid after 2 hours in small intestinal incubations (\u201cSI-2\u201d) as measured in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) model.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 96.0
- Lexical Diversity: 1.44118
- Patent Class: nan
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15988281', '15449781', '15988560', '15449645', '11804259']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5612975631879147
- 35 USC 102 Novelty (BERT): 0.6168898656919903
- Combined Prediction Score: 0.5668567934383223
- Mean Citation Score: 416.622486
- Max Citation Score: 580.3915
- Similarity Product: 546.5712700567244

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test