PATENT CLAIM ANALYSIS

Application Number: 16186879
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-02
Patent Classification: ["514", "001400"]

Abstract:
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.

Claim (Index 3):
A compound of formula (II) wherein\n X 1  is \n X 2  is A 1  is Asp, Cys, D-Cys, Dab, Dap, Glu, Lys, Orn, Pen or D-Pen; A 2  is an L- or D-amino acid; A 3  is His, 2-Pal, 3-Pal, 4-Pal, (X 1 , X 2 , X 3 , X 4 , X 5 )Phe, Taz, 2-Thi or 3-Thi; A 4  is D-Bal, D-1-Nal, D-2-Nal, D-Phe or D-(X 1 , X 2 , X 3 , X 4 , X 5 )Phe; A 5  is Arg, hArg, Dab, Dap, Lys or Orn; A 6  is Bal, 1-Nal, 2-Nal, (X 1 , X 2 , X 3 , X 4 , X 5 )Phe or Trp; A 7  is Asp, Cys, D-Cys, Dab, Dap, Glu, Lys, Orn, Pen or D-Pen; R 1  is H, (C 1 -C 10 )alkyl or substituted (C 1 -C 10 )alkyl; R 2  and R 3  each is, independently, H, (C 1 -C 10 )alkyl, (C 1 -C 10 )heteroalkyl, aryl(C 1 -C 5 )alkyl, substituted (C 1 -C 10 )alkyl, substituted (C 1 -C 10 )heteroalkyl or substituted aryl(C 1 -C 5 )alkyl or R 2  and R 3  may be joined together form a cyclic moiety; R 4  is CO 2 H or C(O)NH 2 ; R 5  and R 6  each is, independently, H, (C 1 -C 10 )alkyl, (C 1 -C 10 )heteroalkyl, aryl(C 1 -C 5 )alkyl, substituted (C 1 -C 10 )alkyl, substituted (C 1 -C 10 )heteroalkyl or substituted aryl(C 1 -C 5 )alkyl or R 5  and R 6  may be joined together form a cyclic moiety; R 7  and R 8  each is, independently, H, (C 1 -C 10 )alkyl, (C 1 -C 10 )heteroalkyl, aryl(C 1 -C 5 )alkyl, substituted (C 1 -C 10 )alkyl, substituted (C 1 -C 10 )heteroalkyl or substituted aryl(C 1 -C 5 )alkyl; or R 7  and R 8  may be joined together form a cyclic moiety; R 9  is H, (C 1 -C 10 )alkyl or substituted (C 1 -C 10 )alkyl; and n is, independently for each occurrence thereof, 1, 2, 3, 4, 5, 6 or 7; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 98.0
- Lexical Diversity: 1.46875
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12602010', '14024961', '13074565', '11988468', '15055873']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8819788042182853
- 35 USC 102 Novelty (BERT): 0.646133872147126
- Combined Prediction Score: 0.8583943110111694
- Mean Citation Score: 625.486862
- Max Citation Score: 672.6033
- Similarity Product: 572.6297659379126

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test