PATENT CLAIM ANALYSIS

Application Number: 15893094
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["530", "350000"]

Abstract:
The present disclosure provides compositions including recombinant K1-5 bacteriophages, methods for making the same, and uses thereof. The recombinant K1-5 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.

Claim (Index 27):
A method for making a recombinant K1-5 bacteriophage in a bacterial host cell comprising\n (a) contacting a non-recombinant K1-5 bacteriophage genome with a first sgRNA-CRISPR enzyme complex and a second sgRNA-CRISPR enzyme complex in vivo under conditions where\n (i) the first sgRNA-CRISPR enzyme complex cleaves a first protospacer sequence 5\u2032 TATATTATACCAGAGAGGCG 3\u2032 (SEQ ID NO: 8) within the non-recombinant K1-5 bacteriophage genome; and \n (ii) the second sgRNA-CRISPR enzyme complex cleaves a second protospacer sequence 5\u2032 GAAGTTCTAAGGAGATAACA 3\u2032 (SEQ ID NO: 9) within the non-recombinant K1-5 bacteriophage genome to produce a cleaved non-recombinant K1-5 bacteriophage genome; \n (b) recombining in vivo the cleaved non-recombinant K1-5 bacteriophage genome with a heterologous nucleic acid sequence in the presence of a recombination system under conditions to produce the recombinant K1-5 bacteriophage genome, wherein the bacterial host cell is infected with the non-recombinant K1-5 bacteriophage genome, and wherein the heterologous nucleic acid sequence comprises an open reading frame that encodes a bioluminescent protein, a fluorescent protein, a chemiluminescent protein, or any combination thereof.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 88.0
- Lexical Diversity: 1.25714
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15893104', '15420936', '15179912', '15507176', '15060424']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5803312639547344
- 35 USC 102 Novelty (BERT): 0.6310532142510104
- Combined Prediction Score: 0.5854034589843621
- Mean Citation Score: 439.2102880000001
- Max Citation Score: 709.44403
- Similarity Product: 505.9439176415754

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test