PATENT CLAIM ANALYSIS

Application Number: 16182387
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["544", "182000"]

Abstract:
The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.

Claim (Index 3):
A compound in accordance with Formula B, wherein M is a substituted amino moiety, \u2014NR 6 R 7 , wherein R 6  and R 7  are each independently selected from the group consisting of H, lower alkyl, \u2014(CH 2 CH 2 O) m R 8 , \u2014CH 2 CH 2 -(3-7 membered heterocycloalkyl), \u2014C(O)\u2014CH 2 (CH 2 CH 2 O) m R 10 , \u2014CH 2 CR 9 HCH 2 O(CH 2 CH 2 O) m (CH 2 ) 0,1 R 10 , \u2014CR 11 R 12 CH 2 OH, \u2014CR 11 R 12 CH 2 O(CH 2 CH 2 O) 1-7 R 10 , \u2014CH\u2014[CH 2 OH] 2 ; \u2014CCH 3 (CH 2 OH) 2 , \u2014CCH 3 (CH 2 OH)CH 2 O(CH 2 CH 2 O) 1-7 R 10 , alkylamino, hydroxyalkylamino, \u2014CH 2 CH 2 NCH 3 C(O)CH 2 (OCH 2 CH 2 ) 1-7 R 10 , \u2014CH 2 CH 2 NCH 3 C(O)CH 2 OCH 2 C(O)NH 2 , \u2014CH 2 CH 2 NCH 3 (CH 2 CH 2 O) 1-7 R 10 , \u2014CR 11 R 12 CH(O), \u2014CR 11 R 12 (CH 2 ) 1 or 2 SO 2 \u2014CH 2 CH 2 O) 1-7 R10, \u2014CCH 3 (CH 2 OCH 2 CH 2 OCH 3 ) 2 , \u2014OCH 2 CR 9 HCH 2 OR 10 \u2014CH 2 CR 9 HCH 2 NHC(O)CH 2 O(CH 2 CH 2 O) m R 10 , \u2014CH 2 CR 9 HCH 2 NHC(O)CH 2 OCH 2 C(O)NH 2 , and \u2014(OCH 2 CH 2 ) m OR 10 , with the proviso that R 6  and R 7  are not both H, or wherein R 6  and R 7  taken together with N form a heterocycloalkyl ring selected from piperazine, piperidine, and azetidine, which may optionally form part of a bicyclic ring structure, where the heterocycloalkyl ring or bicyclic ring is either unsubstituted or is substituted with a group selected from lower alkyl, \u2014(CH 2 CH 2 O) m R 8 , \u2014C(O)\u2014CH 2 (CH 2 CH 2 O) m R 10 , \u2014CH 2 CR 9 HCH 2 O(CH 2 CH 2 O) m (CH 2 ) 0,1 R10, \u2014CH 2 CH 2 SO 2 CH 3 , \u2014NR 9 (CH 2 CH 2 O) m R 10 , tetra-hydro-2H-pyranyl, piperidinyl, \u2014CH 2 OH, \u2014CH 2 R 10 , amino, \u2014CHCH 3 CH 2 OH, hydroxyl, \u2014CR 11 R 12 CH 2 OH, \u2014C(O)OCH 3 , \u2014CF 3 , \u2014CH 2 C(OH)CF 3 , \u2014CH 2 OCH 2 \u2014C 6 H 5 F, and \u2014CH 2 CR 9 HCH 2 O(CH 2 CH 2 O) m (CH 2 ) 0,1 R 13 , m is in a range from 0-29, R 8  is selected from H, C1-C6 alkyl, fluoro-substituted methyl, \u2014CH 2 COOR 10 , \u2014CH 2 COCH 3 , 3-7 membered heterocycloalkyl, 3-7 membered heteroaryl, heteroarylalkyl, \u2014C(O)OCH 3 , C1-C6 alkyl substituted with one or more of hydroxyl, amino, alkylamino, amido, alkylamide, amidoalkylamine, acylamino, carboxyalkylamino, sulfonamide, sulfone, alkylsulfone, alkoxyalkyl sulfone, alkyloxyalklsulfoxide, 3-7 membered heterocycloalkyl, 5-6 membered heteroaryl, carboxyl, \u2014NHCH 2 CH 2 OCH 3 , \u2014NHCHR 9 COOR 11 ; and \u2014CH\u2014[CH 2 O\u2014(CH 2 CH 2 O) 2-8 CH 3 ] 2 ; R 9  is H, lower alkyl, hydroxyl, R 10  is selected from H, lower alkyl and fluoro-substituted methyl, R 11  and R 12  are each independently selected from H and lower alkyl, R 13  is cyclopropyl or cyclobutyl, and W is an optional substituent selected from the group consisting of halo, hydroxyl, and oligomeric ethylene oxide (\u2014OCH 2 CH 2 ) n OR, where n ranges from 1-7 and R is selected from H, -lower alkyl and fluoro-substituted methyl, and pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 98.0
- Lexical Diversity: 1.19355
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15106741', '13576798', '14322505', '11560378', '12468188']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8362927129972941
- 35 USC 102 Novelty (BERT): 0.5746371214641078
- Combined Prediction Score: 0.8101271538439755
- Mean Citation Score: 396.158786
- Max Citation Score: 508.57773
- Similarity Product: 402.5713006993407

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test