PATENT CLAIM ANALYSIS

Application Number: 15900698
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["435", "348000"]

Abstract:
Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein. Methods and tools for identifying an agent that modulates intracellular calcium, to screen for an agent that modulates NFAT regulator function, to diagnose unexplained immunodeficiency in a subject, and for identifying an agent for treating or preventing a disease or disorder associated with a NFAT regulator protein or calcium signaling are also disclosed.

Claim (Index 1):
A recombinant cell comprising heterologous nucleic acid encoding at least one mammalian Nuclear Factor of Activated T cells (NFAT) regulator protein, wherein the heterologous nucleic acid is a mammalian NFAT regulator gene, wherein the NFAT regulator gene is ORAI selected from ORAI1, ORAI2, ORAI3 or a homologue or derivative thereof; and the recombinant cells is an isolated cell.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 2.54412
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14832922', '12160030', '13161307', '13877472', '12575655']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6252017722553003
- 35 USC 102 Novelty (BERT): 0.6760301459331378
- Combined Prediction Score: 0.630284609623084
- Mean Citation Score: 534.718878
- Max Citation Score: 702.3056
- Similarity Product: 653.8942307518006

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test