PATENT CLAIM ANALYSIS

Application Number: 16007099
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["544", "280000"]

Abstract:
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Claim (Index 21):
A method of treating an TYK2-mediated disorder, disease, or condition in a patient comprising administering to said patient a compound of formula I, or a pharmaceutical composition thereof: or a pharmaceutically acceptable salt thereof, wherein: each of X and Y is independently \u2550C(R 6 )\u2014 or \u2550N\u2014; Ring A is phenyl; a 5-6 membered partially unsaturated monocyclic heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 6-12 membered partially unsaturated bicyclic heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or a 7-12 membered bicyclic heteroaryl ring having 2-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; each of R 1  and R 1\u2032  is independently hydrogen, \u2014R 2 , halogen, \u2014CN, \u2014NO 2 , \u2014OR, \u2014SR, \u2014NR 2 , \u2014S(O) 2 R, \u2014S(O) 2 NR 2 , \u2014S(O)R, \u2014C(O)R, \u2014C(O)OR, \u2014C(O)NR 2 , \u2014C(O)N(R)OR, \u2014OC(O)R, \u2014OC(O)NR 2 , \u2014N(R)C(O)OR, \u2014N(R)C(O)R, \u2014N(R)C(O)NR 2 , or \u2014N(R)S(O) 2 R; or\n R 1  and R 1\u2032  are taken together with their intervening atoms to form an optionally substituted 3-7 membered spiro-fused ring having 0-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; \n each R 2  is independently an optionally substituted group selected from C 1-6  aliphatic, phenyl, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; R 3  is C 2-6  aliphatic or Cy 1 ; wherein R 3  is substituted with n instances of R 8 ; R 5  is halogen, \u2014CN, \u2014NO 2 , \u2014OR, \u2014SR, \u2014NR 2 , \u2014S(O) 2 R, \u2014S(O) 2 NR 2 , \u2014S(O)R, \u2014C(O)R, \u2014C(O)OR, \u2014C(O)NR 2 , \u2014C(O)N(R)OR, \u2014OC(O)R, \u2014OC(O)NR 2 , \u2014N(R)C(O)OR, \u2014N(R)C(O)R, \u2014N(R)C(O)NR 2 , \u2014N(R)S(O) 2 R, and Cy 2 ; wherein R 5  is substituted with p instances of R 9 ; or when Ring A is partially unsaturated, L 1 R 5 , taken together, may also be absent; each of Cy 1  and Cy 2  is independently phenyl; a 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring; a 6-12 membered bicyclic carbocyclic ring; a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 6-12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; each instance of R 6  is independently hydrogen, \u2014R 2 , halogen, \u2014CN, \u2014NO 2 , \u2014OR, \u2014SR, \u2014NR 2 , \u2014S(O) 2 R, \u2014S(O) 2 NR 2 , \u2014S(O)R, \u2014C(O)R, \u2014C(O)OR, \u2014C(O)NR 2 , \u2014C(O)N(R)OR, \u2014OC(O)R, \u2014OC(O)NR 2 , \u2014N(R)C(O)OR, \u2014N(R)C(O)R, \u2014N(R)C(O)NR 2 , or \u2014N(R)S(O) 2 R; each instance of R 7  and R 8  is independently oxo, \u2014R 2 , halogen, \u2014CN, \u2014NO 2 , \u2014OR, \u2014SR, \u2014NR 2 , \u2014S(O) 2 R, \u2014S(O) 2 NR 2 , \u2014S(O)R, \u2014C(O)R, \u2014C(O)OR, \u2014C(O)NR 2 , \u2014C(O)N(R)OR, \u2014OC(O)R, \u2014OC(O)NR 2 , \u2014N(R)C(O)OR, \u2014N(R)C(O)R, \u2014N(R)C(O)NR 2 , or \u2014N(R)S(O) 2 R; each instance of R 9  is independently oxo, C 1-6  hydroxyaliphatic, \u2014R 2 , halogen, \u2014CN, \u2014NO 2 , \u2014OR, \u2014SR, \u2014NR 2 , \u2014S(O) 2 R, \u2014S(O) 2 NR 2 , \u2014S(O)R, \u2014C(O)R, \u2014C(O)OR, \u2014C(O)NR 2 , \u2014C(O)N(R)OR, \u2014OC(O)R, \u2014OC(O)NR 2 , \u2014N(R)C(O)OR, \u2014N(R)C(O)R, \u2014N(R)C(O)NR 2 , or \u2014N(R)S(O) 2 R; L 1  is a covalent bond or a C 1-6  bivalent saturated or unsaturated, straight or branched hydrocarbon chain wherein one or two methylene units of the chain are optionally and independently replaced by \u2014N(R)\u2014, \u2014N(R)C(O)\u2014, \u2014C(O)N(R)\u2014, \u2014N(R)S(O) 2 \u2014, \u2014S(O) 2 N(R)\u2014, \u2014O\u2014, \u2014C(O)\u2014, \u2014OC(O)\u2014, \u2014C(O)O\u2014, \u2014S\u2014, \u2014S(O)\u2014 or \u2014S(O) 2 \u2014; m is 0-2; n is 0-4; p is 0-3; and each R is independently hydrogen, or an optionally substituted group selected from C 1-6  aliphatic, phenyl, a 4-7 membered saturated or partially unsaturated heterocyclic having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or:\n two R groups on the same nitrogen are taken together with their intervening atoms to form a 4-7 membered saturated, partially unsaturated, or heteroaryl ring having 0-3 heteroatoms, in addition to the nitrogen, independently selected from nitrogen, oxygen, and sulfur.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 94.0
- Lexical Diversity: 1.33333
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15097402', '15457657', '14857029', '15590523', '15783250']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7892899902456084
- 35 USC 102 Novelty (BERT): 0.517448885561646
- Combined Prediction Score: 0.7621058797772122
- Mean Citation Score: 309.94717799999995
- Max Citation Score: 332.1104
- Similarity Product: 273.4791096172333

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test