PATENT CLAIM ANALYSIS

Application Number: 15884651
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "001100"]

Abstract:
The iCP-RF recombinant protein of present invention could mediate generation of the induced pluripotent stem cells (iPSCs) from terminally differentiated somatic cells.

Claim (Index 30):
A recombinant protein, which comprises a RF protein selected from the group consisting of OCT4, SOX2, CMYC, KLF4, NANOG, LIN28 and ZSCAN4, and an advanced macromolecule transduction domain (aMTD) being composed of 9 to 13 amino acid sequences and having improved cell or tissue permeability,\n wherein the aMTD is fused to one end or both ends of the RF protein and has the following features of: (a) being composed of 3 or more amino acids sequences selected from the group consisting of Ala, Val, Ile, Leu, and Pro; (b) having proline as amino acids corresponding to any one or more of positions 5 to 8, and 12 of its amino acid sequence; and (c) having an instability index of 40 to 60; an aliphatic index of 180 to 220; and a grand average of hydropathy (GRAVY) of 2.1 to 2.6, as measured by Protparam.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 86.0
- Lexical Diversity: 1.08696
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15432662', '15879664', '15503117', '12528919', '12676182']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8514100787108357
- 35 USC 102 Novelty (BERT): 0.6376877737930186
- Combined Prediction Score: 0.830037848219054
- Mean Citation Score: 493.835162
- Max Citation Score: 672.4202
- Similarity Product: 552.6072604444504

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test