PATENT CLAIM ANALYSIS

Application Number: 15916271
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-01
Patent Classification: ["435", "006100"]

Abstract:
The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of a nucleic acid.

Claim (Index 28):
A method of detecting a single-stranded target RNA in a sample, the method comprising:\n a) contacting the sample with:\n (i) a RNA guide or a nucleic acid encoding the RNA guide, wherein the RNA guide comprises a direct repeat sequence and a spacer sequence capable of hybridizing to the target RNA; \n (ii) a Type VI-D CRISPR-Cas effector protein or a nucleic acid encoding the effector protein; and \n (iii) a labeled detector RNA; \n wherein the effector protein associates with the RNA guide to form a complex; \n wherein the RNA guide hybridizes to the target RNA; and wherein upon binding of the complex to the target RNA, the Type VI-D CRISPR-Cas effector protein exhibits collateral RNAse activity and cleaves the labeled detector RNA; and b) measuring a detectable signal produced by cleavage of the labeled detector RNA, wherein said measuring provides for detection of the single-stranded target RNA in the sample.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.59259
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15467922', '15897089', '15783770', '15507176', '13842859']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.2847646270443656
- 35 USC 102 Novelty (BERT): 0.5485771300743997
- Combined Prediction Score: 0.311145877347369
- Mean Citation Score: 379.938508
- Max Citation Score: 389.89246
- Similarity Product: 327.41788377782825

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test