PATENT CLAIM ANALYSIS

Application Number: 16036619
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["424", "093210"]

Abstract:
The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.

Claim (Index 1):
A method for providing cells expressing heterologous KGF-2 comprising:\n a) providing immortalized keratinocytes selected from the group consisting of NIKS cells and cells derived from NIKS cells and an expression vector comprising a DNA sequence encoding KGF-2 operably linked to a regulatory sequence selected from an involucrin promoter and a K14 promoter; b) introducing said expression vector to said immortalized keratinocytes; and c) culturing said immortalized keratinocytes to form an in vitro human skin equivalent comprising stratified squamous epithelia that expresses KGF-2, wherein said in vitro human skin equivalent is characterized in having correct tissue architecture including the formation of desmosomes, hemidesmosomes, and basal lamina.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.85
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13343314', '10909119', '12690160', '14335534', '11297916']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8383120410570183
- 35 USC 102 Novelty (BERT): 0.6095164614350943
- Combined Prediction Score: 0.815432483094826
- Mean Citation Score: 616.6766919999999
- Max Citation Score: 631.53076
- Similarity Product: 481.3459683570052

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test