PATENT CLAIM ANALYSIS

Application Number: 16195128
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "001100"]

Abstract:
The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.

Claim (Index 1):
A method for treating cancer by stimulating or enhancing a tumor antigen-specific immune response in a human subject, the method comprising:\n administering to the human subject a composition comprising (i) an expanded population of isolated T cells that are specific to more than one tumor antigen and are not genetically engineered; and (ii) a nanostructure conjugated to the surface of the isolated T cells, the nanostructure comprising a plurality of biologically-active proteins reversibly and covalently crosslinked to each other through a degradable linker, wherein the biologically-active proteins comprise an immunostimulatory cytokine, and wherein the linker degrades under physiological conditions to release the biologically-active proteins, wherein upon release in vivo, the biologically-active proteins stimulate or enhance a tumor antigen-specific response in a human subject, thereby treating cancer.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 98.0
- Lexical Diversity: 1.11905
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15470169', '14498386', '15213991', '13946313', '15427017']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.789644615402778
- 35 USC 102 Novelty (BERT): 0.6603587066471625
- Combined Prediction Score: 0.7767160245272164
- Mean Citation Score: 408.455374
- Max Citation Score: 667.25964
- Similarity Product: 569.8247201471687

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test