PATENT CLAIM ANALYSIS

Application Number: 15965655
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["544", "010000"]

Abstract:
The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Claim (Index 31):
The method of  claim 1 , wherein the compound of Formula 1 is represented by: wherein Y is C(R 11 ) 2 , S(O) y , NR Y  and O wherein y is 0 or 1; R Y  is selected from the group consisting of H, methyl, ethyl, propyl, phenyl and benzyl; R m\u2032  and R m  are each independently selected from the group consisting of H, halogen, C 1-6  alkyl (optionally substituted by one, two or three substituents each independently selected from halogen and hydroxyl), C 2-6 alkenyl (optionally substituted by one, two or three substituents each independently selected from halogen and hydroxyl), NR\u2032R\u2033, and hydroxyl; R c  is H; R 78  is selected from the group consisting of H, halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, phenyl, heteroaryl, C 3-6 cycloalkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 1, 2 or 3), and \u2014NR\u2032\u2014S(O) w , (where w is 1, 2 or 3)); R 79  is selected from the group consisting of H, halogen, hydroxyl, nitro, cyano, carboxy, C 1-6  alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, phenyl, heteroaryl, C 3-6 cycloalkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 1, 2 or 3), and \u2014NR\u2032\u2014S(O) w , (where w is 1, 2 or 3)); R\u2032 is selected, independently for each occurrence, from H, methyl, ethyl, and propyl; R\u2033 is selected, independently for each occurrence, from H, methyl, ethyl, propyl, butyl, \u2014C(O)-methyl and \u2014C(O)-ethyl, or R\u2032 and R\u2033 taken together with the nitrogen to which they are attached may form a 4-6 membered heterocycle; each of moieties R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10  is independently selected for each occurrence from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkynyl, C 2-6 alkenyl, halogen, hydroxyl, nitro, cyano, and NR\u2032R\u2033; wherein for each occurrence, C 1-6 alkyl may be optionally substituted with one, two, or three substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, \u2014NR\u2032\u2014S(O) w , and S(O) w \u2014NR\u2032R\u2033; C 1-6 alkoxy may be optionally substituted with one, two, or three substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, NR\u2032R\u2033, \u2014NR\u2032\u2014S(O)) w , and S(O) w \u2014NR\u2032R\u2033; C 3-6 cycloalkyl may be optionally substituted with one, two, or three substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 1-6 alkyl, C 1-6 alkoxy, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, and NR\u2032R\u2033; phenyl may be optionally substituted by one, two or three substituents each independently selected from the group consisting of halogen, hydroxyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, NR\u2032R\u2033, C(O)\u2014NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C(O)\u2014C 1-6 alkoxy, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), NR\u2032\u2014S(O) w , and \u2014S(O) w \u2014NR\u2032R\u2033(where w is 1, 2 or 3), and heteroaryl may be optionally substituted by one, two or three substituents each independently selected from the group consisting of halogen, hydroxyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkoxy, NR\u2032R\u2033, C(O)\u2014NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 -alkyl, \u2014C(O)\u2014C 1-6 alkoxy, \u2014S(O) w \u2014C 1-6 alkyl (where w is 1, 2 or 3), NR\u2032\u2014S(O) w , and \u2014S(O) w \u2014NR\u2032R\u2033(where w is 1, 2 or 3), and pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 91.0
- Lexical Diversity: 1.17949
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15125911', '15760343', '15030378', '15566633', '12785665']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.807860994567386
- 35 USC 102 Novelty (BERT): 0.5440156388669652
- Combined Prediction Score: 0.781476458997344
- Mean Citation Score: 347.24217600000014
- Max Citation Score: 395.68375
- Similarity Product: 321.23496071361

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test