PATENT CLAIM ANALYSIS

Application Number: 15992287
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "282000"]

Abstract:
The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxycodone, in a manner that substantially decreases or deters the potential for opioid abuse, addiction, illicit and illegal use, and overdose. When delivered at the proper dosage, the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent.

Claim (Index 1):
An oxycodone prodrug of the following formula where the prodrug moiety X is attached covalently to the oxycodone molecule via the 6 position ketone enolate oxygen as the enolate ester, or a pharmaceutically acceptable salt thereof, wherein X is covalently attached to the oxycodone, and is a) a monomeric alpha-hydroxy carboxylic acid, b) a homo-oligomer of alpha-hydroxy carboxylic acid, c) a hetero-oligomer of alpha-hydroxy carboxylic acid, d) a hetero-oligomer of alpha-hydroxy carboxylic acid with dicarboxylic acid, e) a hetero-oligomer of alpha-hydroxy carboxylic acid with fatty acid, f) a hetero-oligomer of alpha-hydroxy carboxylic acid with amino acid wherein\n i) a hydroxy group of the alpha-hydroxy carboxylic acid is covalently linked to a carbonyl of the amino acid, and the amino acid of the hetero-oligomer is selected from the group consisting of glycine, alanine, leucine, isoleucine, aspartic acid, glutamic acid, serine, threonine, glutamine, asparagine, arginine, lysine, proline, phenylalanine, tyrosine, tryptophan, cysteine, methionine, histidine, beta alanine, beta amino acids, gamma amino acids, and epsilon amino acids, or \n ii) a carboxyl group of the amino acid is covalently linked to the oxycodone and an amino group of the amino acid is covalently linked as an amide to a carboxyl group of the alpha-hydroxy carboxylic acid.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 93.0
- Lexical Diversity: 1.36957
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15472758', '14953392', '14956143', '10800898', '11635788']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8411819544297038
- 35 USC 102 Novelty (BERT): 0.5520498514454373
- Combined Prediction Score: 0.8122687441312771
- Mean Citation Score: 336.180702
- Max Citation Score: 418.85843
- Similarity Product: 367.5705658821464

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test