PATENT CLAIM ANALYSIS

Application Number: 15971692
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "014200"]

Abstract:
This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1′ residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.

Claim (Index 9):
A modified serpin according to  claim 1  wherein;\n the P4 residue in the RCL of the modified serpin is A, the P2 residue is K, and the P1\u2032 residue is K; \n the P4 residue in the RCL of the modified serpin is A, the P2 residue is R, and the P1\u2032 residue is H; \n the P4 residue in the RCL of the modified serpin is A, the P2 residue is K, and the P1\u2032 residue is H; \n the P4 residue in the RCL of the modified serpin is A, the P2 residue is R, and the P1\u2032 residue is Q; \n the P4 residue in the RCL of the modified serpin is A, the P2 residue is K, and the P1\u2032 residue is Q; \n the P4 residue in the RCL of the modified serpin is A, the P2 residue is K, the P1 residue is R and the P1\u2032 residue is K; \n the P4 residue in the RCL of the modified serpin is A, the P2 residue is K, the P1 residue is R and the P1\u2032 residue is Q; or \n the P4 residue in the RCL of the modified serpin is A, the P2 residue is R, the P1 residue is R and the P1\u2032 residue is Q; \n the P4 residue in the RCL of the modified serpin is K, the P2 residue is R and the P1\u2032 residue is H; \n the P4 residue in the RCL of the modified serpin is F, the P2 residue is K and the P1\u2032 residue is K; \n the P4 residue in the RCL of the modified serpin is F, the P2 residue is R and the P1\u2032 residue is K; or \n the P4 residue in the RCL of the modified serpin is S, the P2 residue is H and the P1\u2032 residue is R.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 93.0
- Lexical Diversity: 1.22222
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15103420', '11825627', '15034385', '12676203', '12179951']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6839558221986433
- 35 USC 102 Novelty (BERT): 0.5944617381498101
- Combined Prediction Score: 0.6750064137937599
- Mean Citation Score: 310.5061740000001
- Max Citation Score: 645.6493
- Similarity Product: 383.6942753395498

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test