PATENT CLAIM ANALYSIS

Application Number: 15957474
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["424", "400000"]

Abstract:
Described herein are drug delivery systems for delivering biologically active agents comprising primary or secondary amines, or a ring nitrogen atom of an azaheteroaryl ring, pharmaceutically acceptable salts thereof, drug delivery reagents related thereto, pharmaceutical compositions comprising the drug delivery systems, and the use of the drug delivery systems as sustained release therapeutics.

Claim (Index 69):
A drug delivery system or pharmaceutically acceptable salt thereof comprising D-R, that is represented by Formula (I), where D is a biologically active moiety comprising at least one primary or secondary amine or a ring nitrogen atom of an azaheteroaryl ring; and\n R is a linker suitable for release of biologically active moiety D: where the dashed line indicates attachment to the primary amine, secondary amine, or ring nitrogen atom of an azaheteroaryl ring; R 1  is hydrogen or C 1 -C 4 alkyl; R 1a  is hydrogen or C 1 -C 4 alkyl, or CR 1 R 1a , taken in combination form a C 3 -C 6 cycloalk-1,1-diyl; R 2  is independently selected at each occurrence from C 1 -C 4 alkyl or oxo, or two R 2  groups taken in combination with the carbon atom(s) to which they are attached form a fused C 3 -C 6  cycloalkyl or spiro C 3 -C 6 cycloalk-1,1-diyl group; a is 0, 1, 2, 3 or 4; R 3  is hydrogen or C 1 -C 4 alkyl; R 3a  is hydrogen, C 1 -C 4 alkyl, or CR 3 R 3a , taken in combination form a C 3 -C 6 cycloalk-1,1-diyl; Y is C(O)R 4 , C(O)OR 4 , C(O)NHR 4 , C(O)NR 5 R 6 , SiR 5 R 6 R 7 , or CR 12 R 12a OR 13 ; R 12  is hydrogen or C 1 -C 4 alkyl; R 12a  is hydrogen or C 1 -C 4 alkyl, or CR 12 R 12a , taken in combination form a C 3 -C 6 cycloalk-1,1-diyl; R 13  is C 1 -C 4 alkyl; or R 12  and R 13 , taken in combination with C(R 12a ) and O form a 5, 6, or 7-member cyclic ether; R 4  is C 1 -C 8 alkyl or C 3 -C 7 cycloalkyl, wherein cycloalkyl is optionally substituted with 0, 1, or 2 independently selected C 1 -C 4 alkyl groups and wherein alkyl is optionally substituted by C 1 -C 4 alkoxy; R 5  and R 6  are each independently selected from C 1 -C 4 alkyl and C 3 -C 6 cycloalkyl; R 7  is C 1 -C 8 alkyl, C 3 -C 7 cycloalkyl, C 1 -C 8 alkoxy, C 3 -C 7 cycloalkyloxy, heterocycloalkyloxy, or \u2014(OCHR 3 CH 2 ) b O\u2014C 1 -C 4 alkyl, wherein the heterocycloalkyloxy is a 4 to 7 member saturated heterocyclic ring having one ring heteroatom selected from N, O, and S and optionally substituted with 0, 1, or 2 independently selected C 1 -C 4 alkyl groups; b is an integer of from 1 to 10; Z is CH-L-A, CH-A, N-L-A, or N-A; L is an optionally substituted bivalent linker; A is hydrogen, C 1 -C 8 alkyl, C(O)C 1 -C 8 alkyl, C(O)N(H)C 1 -C 8 alkyl, C(O)OC 1 -C 8 alkyl, R 10 , or R 11 , wherein the alkyl group is optionally substituted with 0 or 1 R 10 ; R 10  is a reactive functional group suitable for coupling Formula (I) to a carrier; and R 11  is a carrier.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 91.0
- Lexical Diversity: 1.43902
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11150522', '13397195', '14849270', '14512059', '13984762']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.697293030819458
- 35 USC 102 Novelty (BERT): 0.5192047215153404
- Combined Prediction Score: 0.6794841998890463
- Mean Citation Score: 264.81159
- Max Citation Score: 277.69498
- Similarity Product: 178.8996709485054

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test