PATENT CLAIM ANALYSIS

Application Number: 15976037
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "249000"]

Abstract:
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (“mGluR2”). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.

Claim (Index 27):
The method of  claim 25 , wherein\n R 1  is phenyl or 2-pyridinyl, each optionally substituted with one or two substituents each independently selected from the group consisting of halo, C 1-4 alkyl, polyhalo-C 1-4 alkyl, \u2014C 1-4 alkyl-O\u2014C 1-4 alkyl, \u2014O\u2014C 1-4 alkyl and polyhalo-C 1-4 alkyloxy; R 2  is selected from the group consisting of Aryl; and Het 2 ; Aryl is phenyl optionally substituted with a halo substituent; Het 2  is (a) a 6-membered aromatic heterocyclyl substituent selected from the group consisting of pyridinyl, pyrimidinyl and pyrazinyl, each of which may be optionally substituted with one or two substituents each independently selected from the group consisting of halo, C 1-4 alkyl, \u2014O\u2014C 1-4 alkyl and NR\u2032R\u2033; or (b) a 5-membered aromatic heterocyclyl selected from the group consisting of thiazolyl, 1,2-oxazolyl, 1,3-oxazolyl and 1H-imidazolyl, each of which may be optionally substituted with a C 1-4 alkyl substituent; R\u2032 and R\u2033 are each independently hydrogen; R 3  is hydrogen; and R 4  is selected from the group consisting of hydrogen, C 1-4 alkyl and \u2014C 1-4 alkyl-O\u2014C 1-4 alkyl; or a N-oxide, or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 93.0
- Lexical Diversity: 1.55556
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15976223', '15500319', '15500600', '15500234', '15500205']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8243823397712259
- 35 USC 102 Novelty (BERT): 0.6064208758902291
- Combined Prediction Score: 0.8025861933831262
- Mean Citation Score: 449.709548
- Max Citation Score: 535.078
- Similarity Product: 480.8578540922403

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test