PATENT CLAIM ANALYSIS

Application Number: 15771648
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["424", "204100"]

Abstract:
Safe, rapid and efficient methods for producing antigen-specific T cells recognizing human papilloma virus or HPV antigens.

Claim (Index 1):
A process for producing an HPV antigen-specific T cell comprising:\n (a) dividing mononuclear cells from any cell source containing na\u00efve immune cells into several portions; (b) stimulating a first portion of said sample with PHA or another mitogen and with IL-2 to produce ATCs activated T cells (\u201cATCs\u201d) that serve antigen presenting functions during subsequent stimulations and optionally treating the ATCs with radiation or another agent to inhibit their outgrowth; (c) separating T cells and T-cell precursor cells from dendritic cells and dendritic precursor cells: (d) cryopreserving or otherwise reserving the T cells and T-cell precursor cells; (e) differentiating the dendritic cells and dendritic precursor cells in the second portion with cytokine(s) or other agent(s) that generate and mature dendritic cells and with at least one HPV peptide antigen or HPV antigen mix to produce antigen-presenting dendritic cells that present at least one HPV peptide antigen, and optionally treating said antigen-presenting dendritic cells with radiation or another agent sufficient to inhibit their outgrowth; (f) stimulating the cryopreserved or otherwise reserved T cells and T-cell precursor cells from (d) with the dendritic antigen-presenting cells produced in (e) in the presence of IL-7 and IL-15 to produce antigen-specific T cells that recognize the at least one HPV peptide antigen; (g) stimulating antigen-specific T cells produced by (f) with the ATCs of (b) in the presence of the at least one HPV peptide antigen, optionally, in the presence of K562 cells or other accessory cells in the presence of IL-2 and/or IL-15; optionally, repeating (g) one or more times; and (h) recovering antigen-specific T cells that recognize at least one peptide antigen.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 91.0
- Lexical Diversity: 1.0
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15885197', '15331659', '14364592', '10222960', '12271576']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7462497227001026
- 35 USC 102 Novelty (BERT): 0.5250777939180432
- Combined Prediction Score: 0.7241325298218967
- Mean Citation Score: 294.7064400000001
- Max Citation Score: 344.2144
- Similarity Product: 272.73811370334624

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test