PATENT CLAIM ANALYSIS

Application Number: 16150254
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "099000"]

Abstract:
An improved method for identifying the size, shape and duration of drug exposure necessary to improve drug treatment in a subject with a bacterial infection. In addition, an improved method for identification of new dosing strategies which optimize the probability of positive treatment outcomes in subjects using resistance inhibitory concentration (RIC), wherein the subject has a bacterial infection caused by a bacterium with a propensity for heteroresistance. Further, an improved method for decreasing the potential for on-therapy drug resistance by determining a patient's RIC prior to administration of fosfomycin treatment, wherein RIC is utilized to differentiate the parameter which is best related to the driver or index of fosfomycin efficacy for the resistant subpopulation present and the required inhibitory concentration of those mutants.

Claim (Index 1):
A method for treating a subject with a bacterial infection that includes infection with a \u201cresistant\u201d mutant subpopulation of  E. coli,  the method comprising administering fosfomycin to a subject according to an optimum dosing interval consistent with the resistance inhibitory concentration (RIC) of fosfomycin required to inhibit the \u201cresistant\u201d mutant subpopulations of  E. coli,  wherein bacterial density is effectively reduced and the \u201cresistant\u201d mutant subpopulation is inhibited.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 1.71795
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14497022', '15136704', '15124651', '13992387', '12967645']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6777539441748087
- 35 USC 102 Novelty (BERT): 0.4932096680395517
- Combined Prediction Score: 0.659299516561283
- Mean Citation Score: 187.557886
- Max Citation Score: 254.78314
- Similarity Product: 230.3315628663636

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test