PATENT CLAIM ANALYSIS

Application Number: 15875948
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["540", "562000"]

Abstract:
A process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided by defining the ammonium ion content of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester.

Claim (Index 17):
A process for preparing 3-[(S)-7-bromo-2-((2-oxopropyl)amino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester represented by the formula (FK) comprising:\n (a) reacting a compound of formula (D), \n with a compound selected from 1-amino-2-propanol, (R)-1-amino-2-propanol, and (S)-1-amino-2-propanol to provide an intermediate compound; and\n (b) reacting said intermediate compound with at least one oxidizing agent in the presence of at least one oxidation catalyst, wherein said at least one oxidation catalyst is selected from the group consisting of:\n (i) 2,2,6,6-tetramethylpiperidin-1-ol; \n (ii) 2,2,6,6-tetramethylpiperidine-1,4-diol; and \n (iii) a compound of formula (I-1): \n \n wherein: R 1 , R 2 , and R 5  independently represent hydrogen, halogen, hydroxy, C 1-3  alkyl or C 1-3  alkoxy; R 3  represents hydrogen or halogen; and X\u2550R 4  represents N\u2014O*, N\u2014OH, or N + \u2550O; \u2003wherein the reaction of the intermediate compound with said at least one oxidizing agent and said at least one oxidation catalyst is conducted in a reaction system satisfying at least one of the following conditions (x), (y) and (z):\n (x) in the absence of an ammonium ion; \n (y) in the presence of an ammonium ion in a weight ratio of 170 ppm or less relative to the compound; and \n (z) in the presence of an ammonium ion in a molar ratio of 145% or less relative to the oxidation catalyst.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 86.0
- Lexical Diversity: 1.91667
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15488361', '14772203', '13496742', '15336143', '14841899']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7175965849058193
- 35 USC 102 Novelty (BERT): 0.6535140238071393
- Combined Prediction Score: 0.7111883287959513
- Mean Citation Score: 426.12473400000016
- Max Citation Score: 636.66614
- Similarity Product: 580.0557619136166

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test