PATENT CLAIM ANALYSIS

Application Number: 16141849
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "275000"]

Abstract:
Methods of treating Alzheimer's disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods comprise the administration of compounds that modulate an activity of cell division control protein 42 (Cdc42), such as the interaction between Cdc42 and intersectin (ITSN). Exemplary modulator compounds include thioureas, disulfonamides of fused aromatic systems (e.g., benzofuran), and acyl hydrazones, among others. Some of the modulator compounds act as activators of Cdc42, while others act as inhibitors. In some cases, the modulator compound has dual functionality and the ability of the modulator compound to act as an inhibitor or activator depends on whether or not Cdc42 is already activated in a particular disease stage or biological environment by an upstream activating signal of Cdc42.

Claim (Index 17):
The method of  claim 15 , wherein A 1  is phenyl or substituted phenyl and L 3  is absent and the compound of Formula (II) has a structure of Formula (IIa): wherein:\n A 2  is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycle, substituted heterocycle, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; \n L 4  is present or absent, and, if present is \u2014(CH 2 ) n \u2014, wherein n is an integer between 1 and 10; \n R 14  and R 15  are independently selected from H, alkyl, and substituted alkyl; \n R 23 , R 24 , R 25 , R 26 , and R 27  are each independently selected from the group consisting of H, halo, nitro, cyano, hydroxyl, carboxyl, acyl, alkyl, substituted alkyl, alkoxyl, aralkoxyl, aryloxyl, amino, and sulfonyl; and \n X 7  is selected from \u2014CH 2 \u2014, \u2014NH\u2014, \u2014O\u2014, and \u2014S\u2014; or \n a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 1.57303
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14009969', '15970268', '14131655', '15554767', '14398386']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7876157660868671
- 35 USC 102 Novelty (BERT): 0.5273428462371929
- Combined Prediction Score: 0.7615884741018998
- Mean Citation Score: 318.787604
- Max Citation Score: 324.82755
- Similarity Product: 231.77933378491403

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test