PATENT CLAIM ANALYSIS

Application Number: 16026397
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["546", "323000"]

Abstract:
The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from such method of purification.

Claim (Index 3):
The compound of  claim 1 ; wherein PG is utilized for the reversible protection of an amine functional group; and wherein PG of formula (I) preferably comprises a moiety of formula (C): wherein:\n the dashed line marked with the asterisk indicates attachment to T of formula (I) and the unmarked dashed line indicates attachment to the nitrogen of an amine functional group; \n X is C(R 4 R 4a ), N(R 4 ), O, C(R 4 R 4a )\u2014C(R 5 R 5a ), C(R 5 R 5a )\u2014C(R 4 R 4a ), C(R 4 R 4a )\u2014N(R 6 ), N(R 6 )\u2014C(R 4 R 4a ), C(R 4 R 4a )\u2014O, or O\u2014C(R 4 R 4a ); \n X 1  is C or S(O); \n X 2  is C(R 7 , R 7a ) or C(R 7 , R 7a )\u2014C(R 8 , R 8a ); \n R 1 , R 1a , R 2 , R 2a , R 3 , R 3a , R 4 , R 4a , R 5 , R 5a , R 6 , R 7 , R 7a , R 8 , and R 8a  are independently selected from the group consisting of H and C 1-6  alkyl; \n optionally, one or more of the pair(s) R 1a /R 4 , R 1a /R 5a , R 4a /R 5a , R 4a /R 5a , and R 7a /R 8a  form a chemical bond; \n optionally, one or more of the pair(s) R 1 /R 1a , R 2 /R 2a , R 4 /R 4a , R 5 /R 5a , R 7 /R 7a , and R 8 /R 8a  are joined together with the atom to which they are attached to form a C 3-8  cycloalkyl or a 4-membered to 7-membered heterocyclyl; \n optionally, one or more of the pair(s) R 1 /R 4 , R 1 /R 5 , R 1 /R 6 , R 4 /R 5 , R 7 /R 8 , and R 2 /R 3  are joined together with the atoms to which they are attached to form a ring A; \n optionally, R 3 /R 3a  are joined together with the nitrogen atom to which they are attached to form a 4-membered to 7-membered heterocycle; \n A is selected from the group consisting of phenyl, naphthyl, indenyl, indanyl, tetralinyl, C 3-10  cycloalkyl, 4-membered to 7-membered heterocyclyl, and 8-membered to 11-membered heterobicyclyl; \n provided that one hydrogen of R 1 , R 1a , R 2 , R 2a , R 3 , R 3a , R 4 , R 4a , R 5 , R 5a , R 6 , R 7 , R 7a , R 8 , or R 8a  is replaced by -T of formula (I); and \n wherein the moiety of formula (C) is optionally further substituted.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 95.0
- Lexical Diversity: 1.17391
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15027976', '14435350', '12990101', '14238437', '14650175']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8390516832019238
- 35 USC 102 Novelty (BERT): 0.5650824916867706
- Combined Prediction Score: 0.8116547640504085
- Mean Citation Score: 374.628792
- Max Citation Score: 520.1981
- Similarity Product: 345.8700452785432

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test