PATENT CLAIM ANALYSIS

Application Number: 16032743
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "210210"]

Abstract:
This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Claim (Index 95):
The method of  claim 78 , wherein the compound is selected from:\n 1-{2-[5-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-3-yl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{2-[6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2-yl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{2-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2-yl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{2-[2-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-4-yl]-2,3-dihydro-1H-inden-2-yl}methanamine; N-({2-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2-yl]-2,3-dihydro-1H-inden-2-yl}methyl)acetamide; N-({6-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridin-6-yl}methyl)acetamide; 1-{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; {2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl)}methanol; N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)acetamide; 2-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)propanamide; N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)cyclopropanecarboxamide; 4-{3-[2-(Fluoromethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-7H-pyrrolo[2,3-d]pyrimidine; 4-{3-[2-(Difluoromethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-7H-pyrrolo[2,3-d]pyrimidine; N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)methanesulfonamide; Methyl ({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)carbamate; N,N-Dimethyl-1-{2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-H-inden-2-yl}methanamine; N-Methyl-1-{2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 4-{3-[2-(Methoxymethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-7H-pyrrolo[2,3-d]pyrimidine; N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)cyclobutanecarboxamide; N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)cyclopentanecarboxamide; N-((((2-3-(7H-Pyrrolo[2-3-d]pyrimidin-4-yl)phenyl)-2,3-dihydro-1H-inden-2-yl)methyl)thiophene-2-carboxamide; 1-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)-1H-pyrazole-3-carboxamide; 4-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)-1,3-oxazole-5-carboxamide; N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)isoxazole-5-carboxamide; 1-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-H-inden-2-yl}methyl)-1H-pyrazole-5-carboxamide; 1-Methyl-N-({2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)-1H-pyrazole-4-carboxamide; N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)-2-furamide; N-({2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)morpholine-4-carboxamide; {2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-H-inden-2-yl}acetonitrile; 2-{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}ethanamine; 2-Methyl-N-(2-{2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}ethyl)propanamide; N-(2-{2-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}ethyl)cyclopropanecarboxamide; N-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclopropanamine; N-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanamine; N-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)-3,3-difluorocyclobutanamine; (2R)-1-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)pyrrolidine-2-carboxamide; (3S)-1-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)pyrrolidine-3-carboxamide; (3S)-1-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)pyrrolidine-3-carbonitrile; (2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(azetidin-1-ylmethyl)-2,3-dihydro-1H-inden-2-yl)methanamine; (2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-((3-fluoroazetidin-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)methanamine; 1-((2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-2-(aminomethyl)-2,3-dihydro-1H-inden-5-yl)methyl)azetidin-3-ol; 2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]indane-5-carbonitrile; N-({5-Cyano-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methyl)cyclopropanecarboxamide; (3S)-1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}pyrrolidine-3-carbonitrile; 1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}-N,N-dimethylpyrrolidin-3-amine; 1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}-N-methylpyrrolidin-3-amine; 1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}pyrrolidin-3-ol; 1-(1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}pyrrolidin-3-yl)ethanol; 1-{5-(3-Fluoroazetidin-1-yl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}azetidin-3-ol; 1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}piperidin-3-ol; 1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}piperidine-4-carbonitrile; N-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}tetrahydro-2H-pyran-4-amine; 1-{5-Pyrrolidin-1-yl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{5-Piperidin-1-yl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{5-Morpholin-4-yl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-H-inden-2-yl}methanamine; 1-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}piperidin-4-ol; 2-(Aminomethyl)-N-(2-methoxyethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]indan-5-amine; 2-(Aminomethyl)-N-(3-methoxypropyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]indan-5-amine; 2-(Aminomethyl)-N-[1-(methoxymethyl)cyclopropyl]-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]indan-5-amine; 1-{5-Phenyl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{5-(2-Fluorophenyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{5-(3-Fluorophenyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{5-(4-Fluorophenyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 4-{2-(Aminomethyl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-5-yl}-N,N-dimethylaniline; 1-{5-Imidazo[1,2-a]pyridin-6-yl-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{5-(3-Methyl-3H-imidazo [4, 5-b]pyridin-6-yl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{5-(6-Pyrrolidin-1-ylpyridin-3-yl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 1-{5-(1-Ethyl-1H-imidazol-4-yl)-2-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; (2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(pyridin-3-yl)-2,3-dihydro-1H-inden-2-yl)methanamine; (2-(3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-5-(pyridin-4-yl)-2,3-dihydro-1H-inden-2-yl)methanamine; 4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-butyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 4-{3-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]phenyl}-N-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 1-{2-[3-(6-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-2,3-dihydro-1H-inden-2-yl}methanamine; 4-{2-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]pyridin-4-yl}-N-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; and 4-{2-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]pyridin-4-yl}-N-[3-(morpholin-4-ylmethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 95.0
- Lexical Diversity: 1.13793
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15247499', '15971017', '15234690', '15624850', '15151259']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.808606458526149
- 35 USC 102 Novelty (BERT): 0.6337493338703968
- Combined Prediction Score: 0.7911207460605738
- Mean Citation Score: 507.6831120000001
- Max Citation Score: 627.3497
- Similarity Product: 524.0912955324172

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test