PATENT CLAIM ANALYSIS

Application Number: 16087557
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["424", "489000"]

Abstract:
Provided is a composition which can be utilized for drug delivery systems that can penetrate the blood brain barrier, and has low cytotoxicity. A nanoparticle composition comprises nanoparticles to the surface of which a first substance and a second substance each having specificity to a tumor cell are bound, wherein the first substance having specificity to the tumor cell is a peptide comprising an amino acid sequence of arginine-glycine-aspartic acid, and wherein the second substance having specificity to the tumor cell is an iron-binding protein, and wherein the nanoparticles each comprise an outer layer and vesicles enveloped by the outer layer and the nanoparticles each comprise, as membrane components, a PEGylated phospholipid, a fatty acid with a melting point of 30° C. or more, and a non-PEGylated phospholipid.

Claim (Index 10):
A method for producing a nanoparticle composition comprising nanoparticles to the surface of which a first substance and a second substance each having specificity to a tumor cell are bound, comprising:\n (i) removing a volatile organic solvent from a solution comprising a PEGylated phospholipid, a fatty acid having a melting point of 30\u00b0 C. or more, and a non-PEGylated phospholipid in the volatile organic solvent to form a membrane, (ii) sonicating the membrane formed in the step (i) in a buffer to produce nanoparticles, and (iii) binding the first substance and the second substance each having specificity to the tumor cell to the surface of the nanoparticles produced in the step (ii), wherein the first substance having specificity to the tumor cell is a peptide comprising an amino acid sequence of arginine-glycine-aspartic acid, and wherein the second substance having specificity to the tumor cell is an iron-binding protein.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 97.0
- Lexical Diversity: 1.94366
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14215879', '13983750', '14765620', '14599291', '14475708']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7168963627079634
- 35 USC 102 Novelty (BERT): 0.5001062258069867
- Combined Prediction Score: 0.6952173490178658
- Mean Citation Score: 243.029726
- Max Citation Score: 256.31534
- Similarity Product: 187.5333616323733

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test