PATENT CLAIM ANALYSIS

Application Number: 16144358
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["525", "410000"]

Abstract:
The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.

Claim (Index 1):
A terminally activated polyoxazoline (POZ) compound of the general structure R 1 -POZ-P p -Q q -W w -U u -X,\n wherein\n POZ is [N(COR 7 )CH 2 CH 2 ] n  \n X is an active functional group; \n P is a linking group selected from the group consisting of: \u2014O\u2014, \u2014S\u2014, NH, \u2014NR 11 \u2014, unsubstituted heterocyclyl, \n Q is a linking group selected from the group consisting of: unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or unsubstituted aralkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, \u2014(CH 2 ) m \u2014CONH\u2014(CH 2 ) m \u2014, \u2014NH\u2014(CH 2 ) m \u2014NHCO\u2014(CH 2 ) m \u2014, \u2014CO\u2014(CH 2 ) m \u2014, \u2014CO\u2014C 6 H 4 \u2014, \u2014CO\u2014R 8 \u2014, \u2014(R 15 ) m \u2014 or \u2014(CR 3 R 4 ) m \u2014; \n U is a linking group selected from the group consisting of: \u2014(R 16 ) o \u2014, \u2014(CR 5 R 6 ), \u2014NH\u2014R 21 \u2014NHCO\u2014R 22 \u2014; \n W is a linking group selected from the group consisting of: \u2014NH\u2014CO\u2014O\u2014, \u2014NH\u2014CO, \u2014NH\u2014CO\u2014NH\u2014, \u2014NH\u2014CS\u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014NH\u2014 and SO\u2014CO\u2014NH; \n R 7  is independently selected for each repeating unit of POZ from an unsubstituted or substituted alkyl, alkenyl or aralkyl group; \n R 1 , R 3 -R 6 , R 11 , R 15 -R 16  and R 21 -R 22  are each independently selected from hydrogen, unsubstituted or substituted alkyl, alkenyl or aralkyl group; \n R 8  is \u2014C 6 H 10 \u2014CH 2 \u2014; \n n is an integer from 3 to 1000; \n m and o are integer independently selected from 1 to 10; \n p, q, w and u are integers independently selected from zero or one.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 1.7551
- Patent Class: 525.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15453686', '12529001', '12680448', '13003306', '13367128']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8006983971040548
- 35 USC 102 Novelty (BERT): 0.539406934073456
- Combined Prediction Score: 0.7745692508009949
- Mean Citation Score: 330.004808
- Max Citation Score: 419.58813
- Similarity Product: 333.69174015049697

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test