PATENT CLAIM ANALYSIS

Application Number: 16514835
Application Type: Utility
Filing Date: 2019-07
Publication Date: 2019-11
Patent Classification: ["514", "252030"]

Abstract:
The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like). Specifically, the present invention provides a compound or an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or the like, the compound

Claim (Index 21):
The compound of  claim 1  or an optical isomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein the compound represented by the formula (I) is represented by the following formula (I-a): where R 1a  and R 1b  are each independently a hydrogen atom, a halogen atom, a cyano group, a C 1-6  alkyl group, a halogenated C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, a cyanated C 1-6  alkyl group, a C 1-6  alkoxy group, a halogenated C 1-6  alkoxy group, a C 1-6  alkoxy C 1-6  alkyl group, a mono-/di-C 2-7  alkanoyl amino group, a \u2014C(\u2550O) NH 2  group, or a C 1-6  alkoxy carbonyl group; R 2a  and R 2b  are each independently a hydrogen atom, a hydroxyl group, a halogen atom, a C 1-6  alkyl group, a halogenated C 1-6  alkyl group, a C 1-6  alkoxy C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, a cyanated C 1-6  alkyl group, a C 1-6  alkoxy group, or a halogenated C 1-6  alkoxy group; X 1  is a nitrogen atom, a C\u2014H, or a C\u2014C 1-6  alkyl group; R 3  is a hydrogen atom, a halogen atom, a C 1-6  alkyl group, a C 3-8  cycloalkyl group, a halogenated C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, a C 6-10  aryl group, a 5- or 6-membered heteroaryl group, or a non-aromatic heterocyclic group (the C 6-10  aryl group, the 5- or 6-membered heteroaryl group, and the non-aromatic heterocyclic group may each have 1 to 3 substituent groups arbitrarily selected from a halogen atom and a C 1-6  alkyl group); R 4a  is a hydrogen atom, a halogen atom, a cyano group, a C 1-6  alkyl group, a halogenated C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, a C 1-6  alkoxy group, a hydroxy C 1-6  alkoxy group, a halogenated C 1-6  alkoxy group, a C 1-6  alkoxy C 1-6  alkyl group, a C 1-6  alkoxy C 1-6  alkoxy group, a C 1-6  alkoxy carbonyl group, a \u2014NR 4c R 4d  group, a \u2014CONR 4c R 4d  group, a R 4c R 4d N\u2014C 1-6  alkoxy group (the R 4c  and R 4d  are each independently a hydrogen atom, a C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, or a halogenated C 1-6  alkyl group), a \u2014C (\u2550O) NH 2  group, a halogenated mono-/di-C 2-7  alkanoyl amino group, or a C 1-6  alkylthio group; and R 4b  is a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a C 1-6  alkyl group, a halogenated C 1-6  alkyl group, a hydroxy halogenated C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, a C 1-6  alkoxy group, a halogenated C 1-6  alkoxy group, a hydroxy C 1-6  alkoxy group, a hydroxy halogenated C 1-6  alkoxy group, a C 1-6  alkoxy C 1-6  alkyl group, a halogenated C 1-6  alkoxy C 1-6  alkyl group, a C 1-6  alkoxy C 1-6  alkoxy group, a hydroxy C 1-6  alkoxy C 1-6  alkoxy group, a C 1-6  alkoxy carbonyl group, a C 1-6  alkoxy carbonyl C 1-6  alkyl group, a carboxy group, a \u2014C(\u2550O)NH 2  group, a C 3-8  cycloalkyl group (the C 3-8  cycloalkyl group may have 1 to 3 substituent groups selected from a hydroxyl group, a halogen atom, a C 1-6  alkyl group, a C 1-6  alkoxy group, and a C 1-6  alkoxy C 1-6  alkyl group), a C 6-10  aryl group (the C 6-10  aryl group may have 1 to 3 substituent groups selected from a hydroxyl group, a cyano group, a halogen atom, a C 1-6  alkyl group, a halogenated C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, a C 3-8  cycloalkyl group, a C 1-6  alkoxy group, a halogenated C 1-6  alkoxy group, a C 1-6  alkoxy C 1-6  alkyl group, a C 1-6  alkoxy carbonyl group, a C 2-6  alkanoyl group, a C 1-6  alkylthio group, a C 1-6  alkylsulfonyl group, a \u2014NR \u03b1 R \u03b2  group, a \u2014CONR \u03b1 R \u03b2  group (the R \u03b1  and R \u03b2  are each independently a hydrogen atom, a C 1-6  alkyl group, a halogenated C 1-6  alkyl group, or a C 3-8  cycloalkyl group), a carboxy group, and a \u2014C(\u2550O)NH 2  group), a 5- or 6-membered heteroaryl group (the 5- or 6-membered heteroaryl group may have 1 to 3 substituent groups selected from a hydroxyl group, a cyano group, a halogen atom, a C 1-6  alkyl group, a halogenated C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, a C 3-8  cycloalkyl group, a C 1-6  alkoxy group, a halogenated C 1-6  alkoxy group, a C 1-6  alkoxy C 1-6  alkyl group, a C 2-6  alkanoyl group, a C 1-6  alkylthio group, a C 1-6  alkylsulfonyl group, a \u2014NR \u03b1 R \u03b2  group, a \u2014NR \u03b1 R \u03b2  group (the R \u03b1  and R \u03b2  are each independently a hydrogen atom, a C 1-6  alkyl group, a halogenated C 1-6  alkyl group, or a C 3-8  cycloalkyl group), a carboxy group, and a \u2014C(\u2550O)NH 2  group), a \u2014NR 4e R 4f  group, a \u2014CONR 4e R 4f  group (the R 4e  and R 4f  are each independently a hydrogen atom, a C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, a halogenated C 1-6  alkyl group, a hydroxy halogenated C 1-6  alkyl group, a C 3-8  cycloalkyl group, or a 5- or 6-membered heteroaryl C 1-6  alkyl group (the 5- or 6-membered heteroaryl in the 5- or 6-membered heteroaryl C 1-6  alkyl group may have 1 to 3 substituent halogen atoms or C 1-6  alkyl groups)), a R 4c R 4d N\u2014C 1 -6 alkoxy group (the R 4c  and R 4d  are each independently a hydrogen atom, a C 1-6  alkyl group, a hydroxy C 1-6  alkyl group, or a halogenated C 1-6  alkyl group), a halogenated mono-/di-C 2 -7 alkanoyl amino group, a C 1-6  alkylthio group, a C 1-6  alkylsulfonyl group, or a halogenated C 1-6  alkylsulfonyl group.

Metadata:
- Claim Count in Document: 116.0
- Percentile: 100.0
- Lexical Diversity: 1.93651
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16138369', '11988659', '13008456', '14477672', '14442609']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7721779787483313
- 35 USC 102 Novelty (BERT): 0.5781395428725402
- Combined Prediction Score: 0.7527741351607522
- Mean Citation Score: 353.857042
- Max Citation Score: 448.06613
- Similarity Product: 429.9712428871477

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test