PATENT CLAIM ANALYSIS

Application Number: 16087308
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["548", "430000"]

Abstract:
Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.

Claim (Index 18):
The method of  claim 16 , characterized in that the compound shown by Formula V is prepared by the following method:\n Step 1: in a solvent, salifying piperic acid under the action of a base and following with a bromination under the action of N-bromosuccinimide (NBS) to obtain a compound shown by Formula II: Step 2: performing an esterification reaction of the compound shown by Formula II with an alcohol (R 3 OH) under a catalysis of an acid to obtain an ester shown by Formula III: Step 3: cyaniding the compound shown by Formula III under the action of a cyanide ion donor to obtain a cyano ester shown by Formula IV: Step 4: performing a cyclopropane lactamization of a cyano ester shown by Formula IV under the action of titanium (IV) isopropoxide (Ti(Oi-Pr) 4 ) and a Grignard reagent of ethylmagnesium halide to obtain a spirocyclopropane lactam shown by Formula V: wherein R 3  is C 1 -C 6  alkyl; X is chlorine, bromine or iodine.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 97.0
- Lexical Diversity: 1.47692
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15514326', '15763676', '16083485', '13994085', '16345744']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7254591328204045
- 35 USC 102 Novelty (BERT): 0.511424660603399
- Combined Prediction Score: 0.704055685598704
- Mean Citation Score: 262.935172
- Max Citation Score: 271.25452
- Similarity Product: 200.5442258691216

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test