PATENT CLAIM ANALYSIS

Application Number: 16353693
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "064000"]

Abstract:
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.

Claim (Index 21):
A compound having the structure of the formula I\u2032 or II\u2032: or a pharmaceutically acceptable salt thereof, wherein: each G is independently selected from the group consisting of \u2014C(O)R 4 , \u2014C(O)(CH 2 ) 0-3 SR 3 , \u2014C(O)(CH 2 ) 1-3 R 4 , \u2014C(O)OR 3 , \u2014C(O)NR 1 R 2 , \u2014C(O)NR 1 OR 3 , \u2014NR 1 C(O)R 4 , NR 1 C(O)NR 1 R 2 , \u2014NR 1 C(O)OR 3 , \u2014NR 1 S(O) 2 R 3 , \u2014NR 1 S(O) 2 NR 1 R 2 , \u2014C(\u2550NR 1 )R 4 , C(\u2550NR 1 )NR 1 R 2 , \u2014NR 1 CR 4 (\u2550NR 2 ), \u2014NR 1 C(\u2550NR 2 )NR 1 R 2 , \u2014S(O) 2 R 3 , \u2014S(O)(CH 2 ) 1-3 R 3 , \u2014S(O) 2 NR 1 R 2 , \u2014S(O) 2 NR 1 OR 3 , \u2014NR 1 S(O) 2 NR 1 OR 3 , \u2014CN, \u2014OR 1 , \u2014SR 1 , \u2014NR 1 R 2 , optionally substituted C 1-10  alkyl, optionally substituted C 2-10 alkenyl, optionally substituted C 2-10 alkynyl, optionally substituted C 3-7  carbocyclyl, optionally substituted 5-10 membered heterocyclyl, optionally substituted C 6-10 aryl, optionally substituted 5-10 membered heteroaryl, optionally substituted C 3-7 carbocyclyl-C 1-6 alkyl, optionally substituted 5-10 membered heterocyclyl-C 1-6 alkyl, optionally substituted C 6-10 aryl-C 1-6 alkyl, and optionally substituted 5-10 membered heteroaryl-C 1-6 alkyl; Y 1  is selected from the group consisting of CR 1  and N; each Y 2  is independently selected from the group consisting of \u2014S\u2014, \u2014S(O)\u2014, \u2014S(O) 2 \u2014, \u2014O\u2014, \u2014CR 1 R 2 \u2014, and \u2014NR 2 \u2014, or Y 2 \u2014(CH 2 ) n -G is CH 3 ; Y 4  is selected from the group consisting of \u2014O\u2014, \u2014S\u2014, and \u2014NR 1 \u2014; Y 5  is selected from the group consisting of \u2014OH, \u2014SH, and \u2014NHR 1 ; Y 6  is selected from the group consisting of \u2014OH, optionally substituted \u2014O\u2014C 1-6  alkyl, \u2014NR 1 R 2 , and \u2014N(OR 3 )R 2 , Q 1  and Q 2  is each independently H or \u2014Y 2 \u2014(CH 2 ) n -G; each n is independently an integer from 0 to 3; m is 0 or 1; A is selected from the group consisting of C 3-10  carbocyclyl, C 6-10  aryl, 5-10 membered heteroaryl, and 5-10 membered heterocyclyl; each R 1 , R 2 , R 3 , and R 4  are independently selected from \u2014H, halogen, optionally substituted C 1-4 alkyl, optionally substituted O\u2014C 1-4 alkyl, optionally substituted C 3-7  carbocyclyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted C 6-10 aryl, and optionally substituted 5-10 membered heteroaryl; R 5  is present 1 to 5 times and each R 5  is independently selected from the group consisting of H, OH, halogen, CN, \u2014C(O)OR 1 ; \u2014C(O)NR 1 R 2 ; \u2014C(O)NR 1 OR 2 ; \u2014NR 1 C(O)R 2 ; \u2014NR 1 C(O)NR 2 R 3 ; \u2014NR 1 C(O)OR 2 ; \u2014NR 1 S(O) 2 R 2 ; \u2014NR 1 S(O) 2 NR 2 R 3 ; \u2014C(\u2550NR 1 )R 2 ; \u2014C(\u2550NR 1 )NR 2 R 3 ; \u2014NR 1 CR 2 (\u2550NR 3 ); \u2014NR 1 C(\u2550NR 2 )NR 3 R 4 ; \u2014S(O)(CH 2 ) 1-3 R 4 , \u2014S(O) 2 NR 1 R 2 , \u2014S(O) 2 NR 1 OR 3 , \u2014NR 1 S(O) 2NR 1 OR 3 , optionally substituted C 2 -C 6  alkenyl, optionally substituted C 2 -C 6  alkynyl, optionally substituted C 1 -C 6  heteroalkyl, optionally substituted C 3 -C 7  carbocyclyl, optionally substituted 5-10 membered heterocyclyl, optionally substituted C 6-10 aryl, optionally substituted 5-10 membered heteroaryl, cyano, C 1 -C 6  alkoxy(C 1 -C 6 )alkyl, aryloxy, sulfhydryl, and \u2014(CH 2 ) p \u2014Y 3 \u2014(CH 2 ) q M\u2032; p and q are each independently 0, 1, or 2; Y 3  is selected from the group consisting of \u2014S\u2014, \u2014S(O)\u2014, \u2014S(O) 2 \u2014, \u2014O\u2014, \u2014CR 1 R 2 \u2014, and \u2014NR 1 \u2014; M\u2032 is selected from the group consisting of halogen, cycano, \u2014OH, \u2014C(O)NR 1 R 2 ; \u2014C(O)NR 1 OR 2 ; \u2014NR 1 C(O)R 2 ; \u2014NR 1 C(O)NR 2 R 3 ; \u2014NR 1 C(O)OR 2 ; \u2014NR 1 S(O) 2 R 2 ; \u2014NR 1 S(O) 2 NR 2 R 3 ; \u2014C(\u2550NR 1 )R 2 ; \u2014C(\u2550NR 1 )NR 2 R 3 ; \u2014NR 1 CR 2 (\u2550NR 3 ); \u2014NR 1 C(\u2550NR 2 )NR 3 R 4 ; \u2014S(O) 2 R 1 , \u2014S(O) 2 NR 1 R 2 , \u2014S(O) 2 NR 1 OR 3 , C 1-4  alkyl optionally substituted with 0-2 substituents selected from the group consisting of \u2014OR 1 , \u2014CN, \u2014NR 1 R 2 , -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; C 2-4  alkenyl optionally substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; C 2-4  alkynyl optionally substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; C 6-10  aryl optionally substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; C 3-7  carbocyclyl optionally substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; 5-10 membered heteroaryl optionally substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; and 3-10 membered heterocyclyl optionally substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; R 6  is selected from the group consisting of is selected from the group consisting of \u2014H, halogen, optionally substituted \u2014C 1-6  alkyl, \u2014OH, \u2014C(O)OR, \u2014P(O)(OR) 2 , \u2014P(O)(OR)R 1 , optionally substituted \u2014O\u2014C 1-6  alkyl, \u2014NR 1 R 2 , \u2014N(OR 3 )R 2 , optionally substituted \u2014S\u2014C 1-6  alkyl, \u2014C(O)NR 1 R 2 , \u2014S(O) 2 NR 1 R 2 , CN, optionally substituted \u2014S(O)\u2014C 1-6  alkyl, and optionally substituted \u2014S(O) 2 \u2014C 1-6  alkyl; R is selected from \u2014H, \u2014C 1-9 alkyl, \u2014CR 10 R 11 OC(O)C 1-9 alkyl, \u2014CR 10 R 11 OC(O)OC 1-9 alkyl, \u2014CR 10 R 11 OC(O)C 6-10 aryl, \u2014CR 10 R 11 OC(O)OC 6-10 aryl, \u2014CR 10 R 11 OC(O)NR 10 C 1-9 alkyl, \u2014CR 10 R 11 OC(O) NR 10 C 6-10 aryl, and; R 7  is selected from the group consisting of OH, optionally substituted \u2014O\u2014C 1-6  alkyl, \u2014NR 1 R 2 , and \u2014N(OR 3 )R 2 ; and R 10  and R 11  are independently selected from the group consisting of \u2014H, optionally substituted C 1-4 alkyl, optionally substituted C 3-7  carbocyclyl, optionally substituted 5-10 membered heterocyclyl, optionally substituted C 6-10 aryl, and optionally substituted 5-10 membered heteroaryl.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 99.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15636424', '15323081', '14146671', '14146643', '15312173']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7938773242263412
- 35 USC 102 Novelty (BERT): 0.557281960318725
- Combined Prediction Score: 0.7702177878355796
- Mean Citation Score: 400.040456
- Max Citation Score: 424.56717
- Similarity Product: 333.7702830476725

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test