PATENT CLAIM ANALYSIS

Application Number: 15756908
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "006100"]

Abstract:
The invention relates to the use of certain micro-RNAs circulating in the blood serum or blood plasma in the form of diagnostic profiles as a marker in an in vitro method for distinguishing between patients for which a myocardial biopsy is necessary for the diagnostic identification of a heart muscle disease and patients for which myocardial biopsy is not necessary, and for the optional differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases affecting the heart.

Claim (Index 9):
The in-vitro or in-vivo method as claimed in  claim 1 , wherein:\n the diagnostic profile for identifying ciHHV6-induced cardiomyopathy additionally comprises at least 3 microRNAs or synthetic nucleic acids having identical or complementary sequences, selected from the group consisting of the following microRNAs:\n hsa-let-7e-5p (SEQ ID NO: 148), hsa-miR-139-3p (SEQ ID NO: 149), hsa-miR-141-3p (SEQ ID NO: 150), hsa-miR-146b-3p (SEQ ID NO: 151), hsa-miR-181c-5p (SEQ ID NO: 152), hsa-miR-3156-5p (SEQ ID NO: 153), hsa-miR-362-5p (SEQ ID NO: 154), hsa-miR-411-5p (SEQ ID NO: 155), hsa-miR-422a (SEQ ID NO: 156), hsa-miR-4535 (SEQ ID NO: 157), hsa-miR-485-3p (SEQ ID NO: 158), hsa-miR-486-3p (SEQ ID NO: 159), hsa-miR-487b-3p (SEQ ID NO: 160), hsa-miR-494-3p (SEQ ID NO: 161), hsa-miR-511-5p (SEQ ID NO: 162), hsa-miR-520f-3p (SEQ ID NO: 163), hsa-miR-548c-3p (SEQ ID NO: 164), hsa-miR-548c-5p (SEQ ID NO: 165), hsa-miR-590-5p (SEQ ID NO: 166), hsa-miR-671-3p (SEQ ID NO: 167), hsa-miR-886-3p (SEQ ID NO: 168), hsa-miR-889-3p (SEQ ID NO: 169), hsa-miR-92a-3p (SEQ ID NO: 170).

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.56
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13899555', '14788843', '15320208', '13642321', '15237364']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6975228020892165
- 35 USC 102 Novelty (BERT): 0.5219459774873842
- Combined Prediction Score: 0.6799651196290333
- Mean Citation Score: 338.831186
- Max Citation Score: 342.94568
- Similarity Product: 232.99049727758407

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test