PATENT CLAIM ANALYSIS

Application Number: 15971692
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "014200"]

Abstract:
This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1′ residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.

Claim (Index 1):
A modified serpin having mutations at residues P1\u2032 and P2 and optionally P1 and/or P4 in the reactive center loop (RCL) thereof,\n wherein the P1\u2032 residue is mutated to Q, H, K or R; and the P2 residue is mutated to H, K or R, and; \n wherein said mutations increase the inhibition of one or more anticoagulant proteases selected from activated Protein C and thrombin:thrombomodulin complex relative to the inhibition of one or more procoagulant proteases selected from thrombin, fVIIa, fXa, fIXa and fXIa.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 93.0
- Lexical Diversity: 1.22222
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15103420', '11825627', '15034385', '12676203', '12179951']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6719583246054237
- 35 USC 102 Novelty (BERT): 0.6296390402244826
- Combined Prediction Score: 0.6677263961673295
- Mean Citation Score: 310.5061740000001
- Max Citation Score: 645.6493
- Similarity Product: 496.1976695985973

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test