PATENT CLAIM ANALYSIS

Application Number: 16090385
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "326000"]

Abstract:
The present invention relates to piperidinylalkylamide derivatives having dual pharmacological activity towards both the sigma (σ) receptor and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

Claim (Index 30):
The compound according to  claim 13 , wherein the compound is selected from:\n N-(1-benzylpiperidin-4-yl)-N-(2-(4-fluorophenyl)pyrimidin-5-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(6-(4-fluorophenyl)pyrazin-2-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(5-(4-fluorophenyl)pyrazin-2-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(5-phenyl-1,3,4-oxadiazol-2-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(3-phenyl-1,2,4-thiadiazol-5-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(4-phenylthiazol-2-yl)propionamide, N-(1-benzylpiperidin-4-yl)-2-methyl-3-oxo-N-(4-phenylthiazol-2-yl)pentanamide, N-(1-benzylpiperidin-4-yl)-N-(5-phenylthiazol-2-yl)propionamide, N-(2-(4-fluorophenyl)pyrimidin-5-yl)-N-(1-phenethylpiperidin-4-yl)propionamide, N-(6-(4-fluorophenyl)pyrazin-2-yl)-N-(1-phenethylpiperidin-4-yl)propionamide, N-(5-(4-fluorophenyl)pyrazin-2-yl)-N-(1-phenethylpiperidin-4-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(1-phenyl-1H-indazol-3-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(1-(4-chlorophenyl)-1H-indazol-3-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(1-(4-fluorophenyl)-1H-indazol-3-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(1-(3-chloro-4-fluorophenyl)-1H-indazol-3-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(1-(4-methoxyphenyl)-1H-indazol-3-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(1-(4-hydroxyphenyl)-1H-indazol-3-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl)propionamide, N-(1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl)-N-(1-phenethylpiperidin-4-yl)propionamide, N-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-N-(1-phenethylpiperidin-4-yl)propionamide, N-(1-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-4-yl)-N-(1-phenethylpiperidin-4-yl)propionamide, N-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-N-(1-phenethylpiperidin-4-yl)acetamide, N-(1-benzylpiperidin-4-yl)-N-(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)propionamide, N-(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)-N-(1-phenethylpiperidin-4-yl)propionamide, N-(1-(4-fluorophenyl)-1H-1,2,3-triazol-5-yl)-N-(1-phenethylpiperidin-4-yl)propionamide, N-(2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl)-N-(1-phenethylpiperidin-4-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(2-(4-fluorophenyl)-2H-1,2,3-triazol-4-yl)propionamide, N-(1-benzylpiperidin-4-yl)-N-(1-phenyl-1H-1,2,3-triazol-4-yl)propionamide, and N-(1-benzylpiperidin-4-yl)-N-(1-(4-fluorophenyl)-1H-1,2,4-triazol-3-yl)propionamide optionally as a stereoisomer, including enantiomers and diastereomers, a racemate or a mixture of at least two stereoisomers, including enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.325
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16090403', '15746877', '15747220', '15531810', '15571352']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8118717451917078
- 35 USC 102 Novelty (BERT): 0.5739084818918849
- Combined Prediction Score: 0.7880754188617255
- Mean Citation Score: 445.959034
- Max Citation Score: 473.35364
- Similarity Product: 364.9657137422323

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test