PATENT CLAIM ANALYSIS

Application Number: 15781985
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "081000"]

Abstract:
Compounds of Formula I and pharmaceutically acceptable salts and co-crystals thereof are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

Claim (Index 1):
A compound of structural Formula I: or pharmaceutically acceptable salt thereof, wherein: R A  is a D-amino acid ester residue of formula (i) or a D-proline ester residue of formula (ii): R 1 , if present, is (a) H, or (b) \u2014C 1-3 alkyl optionally substituted with one to three substituents independently selected from fluoro, chloro, bromo, and \u2014OH; R 2 , if present, is (a) H, (b) (c) \u2014C 1-4 alkyl substituted with \u2014OH, \u2014SH, \u2014SCH 3 , \u2014NH 2  or \u2014NH\u2014C(\u2550NH)\u2014NH 2 , (d) \u2014CH 2 -phenyl, (e) \u2014CH 2 -phenol, (f) \u2014(CH 2 ) 1-2 \u2014COOH, (g) \u2014(CH 2 ) 1-2 \u2014CONH 2 , (h) \u2014CH 2 -1H-indole, (i) \u2014CH 2 -imidazole, (j) aryl or (k) heteroaryl; R 3  is (a) \u2014C 1-10 alkyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 7 , \u2014SH, \u2014NR 8 R 9 , \u2014C 3-6 cycloalkyl or spiro\u2014C 3-6 cycloalkyl, (b) \u2014CH 2 -phenyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 10 , \u2014SH, \u2014NR 8 R 9  or \u2014C 1-3 alkyl, (c) \u2014C 3-8 cycloalkyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 10 , \u2014SH, \u2014NR 8 R 9  or \u2014C 1-3 alkyl, (d) aryl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 10 , \u2014SH, \u2014NR 8 R 9  or \u2014C 1-3 alkyl, (e) \u2014C 1-5 alkyl-X\u2014C 1-5 alkyl wherein X is O, S or NH, (f) heteroaryl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 10 , \u2014SH, \u2014NR 8 R 9  or \u2014C 1-3 alkyl, or (g) a heterocyclic ring unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 10 , \u2014SH, \u2014NR 8 R 9  or \u2014C 1-3 alkyl; R B  is a geminally di-substituted amino acid ester residue of formula (iii): R 4  and R 5  are each independently selected from (a) \u2014C 1-4 alkyl, (b) \u2014C 1-4 alkyl substituted with \u2014OH, \u2014SH, \u2014SCH 3 , \u2014NH 2 , NH\u2014C(\u2550NH)\u2014NH 2 , (c) \u2014CH 2 -phenyl, (d) \u2014CH 2 -phenol, (e) \u2014(CH 2 ) 1-2 \u2014COOH, (f) \u2014(CH 2 ) 1-2 \u2014CONH 2 , (g) \u2014CH 2 -1H-indole, (h) \u2014CH 2 -imidazole, (i) aryl, or (j) heteroaryl; or R 4  and R 5  are joined together with the carbon to which they are both attached to form \u2014C 3-6 cycloalkyl or a 4 to 6-membered heterocyclic ring; R 6  is (a) \u2014C 1-10 alkyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 11 , \u2014SH, \u2014NR 12 R 13 , \u2014C 3-6 cycloalkyl or spiro-C 3-6 cycloalkyl, (b) \u2014CH 2 -phenyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 14 , \u2014SH, \u2014NR 12 R 13 , \u2014C 1-3 alkyl, (c) \u2014C 3-8 cycloalkyl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 14 , \u2014SH, \u2014NR 12 R 13  or \u2014C 1-3 alkyl, (d) aryl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 14 , \u2014SH, \u2014NR 12 R 13  or \u2014C 1-3 alkyl, (e) \u2014C 1-5 alkyl-X\u2014C 1-5 alkyl wherein X is O, S or NH; (f) heteroaryl unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 14 , \u2014SH, \u2014NR 12 R 13  or \u2014C 1-3 alkyl, or (g) a heterocyclic ring unsubstituted or substituted with one to three substituents independently selected from fluoro, chloro, bromo, \u2014OR 14 , \u2014SH, \u2014NR 12 R 13  or \u2014C 1-3 alkyl; R 7  and R 11  are each independently selected from \u2014H or \u2014C 3-6 cycloalkyl; R 8  and R 9  are each independently selected from \u2014H, \u2014C 1-3 alkyl or \u2014C 3-6 cycloalkyl; R 12  and R 13  are each independently selected from \u2014H, \u2014C 1-3 alkyl or \u2014C 3-6 cycloalkyl; and R 10  and R 14  are each independently selected from \u2014H, \u2014C 1-3 alkyl or \u2014C 3-6 cycloalkyl.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 94.0
- Lexical Diversity: 1.58824
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16327631', '16061732', '15231365', '15847971', '15012445']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8269652356499182
- 35 USC 102 Novelty (BERT): 0.6024206758390558
- Combined Prediction Score: 0.804510779668832
- Mean Citation Score: 441.583266
- Max Citation Score: 554.16425
- Similarity Product: 465.18475776915255

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test