PATENT CLAIM ANALYSIS

Application Number: 15975962
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["536", "023100"]

Abstract:
Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.

Claim (Index 5):
The nucleic acid molecule of  claim 1 , wherein the C-5 modified pyrimidine independently, and for each occurrence, is selected from the group consisting a 5-(N-benzylcarboxyamide)-2\u2032-deoxyuridine (BndU), 5-(N-benzylcarboxyamide)-2\u2032-O-methyluridine, 5-(N-benzylcarboxyamide)-2\u2032-fluorouridine, 5-(N-phenethylcarboxyamide)-2\u2032-deoxyuridine (PedU), 5-(N-thiophenylmethylcarboxyamide)-2\u2032-deoxyuridine (ThdU), 5-(N-isobutylcarboxyamide)-2\u2032-deoxyuridine (iBudU), 5-(N-isobutylcarboxyamide)-2\u2032-O-methyluridine, 5-(N-isobutylcarboxyamide)-2\u2032-fluorouridine, 5-(N-tryptaminocarboxyamide)-2\u2032-deoxyuridine (TrpdU), 5-(N-tryptaminocarboxyamide)-2\u2032-O-methyluridine, 5-(N-tryptaminocarboxyamide)-2\u2032-fluorouridine, 5-(N-[1-(3-trimethylamonium) propyl]carboxyamide)-2\u2032-deoxyuridine chloride, 5-(N-naphthylmethylcarboxyamide)-2\u2032-deoxyuridine (NapdU), 5-(N-naphthylmethylcarboxyamide)-2\u2032-O-methyluridine, 5-(N-2-naphthylmethylcarboxyamide)-2\u2032-deoxyuridine (2NapdU), 5-(N-2-naphthylmethylcarboxyamide)-2\u2032-O-methyluridine, 5-(N-naphthylmethylcarboxyamide)-2\u2032-fluorouridine, and 5-(N-[1-(2,3-dihydroxypropyl)]carboxyamide)-2\u2032-deoxyuridine).

Metadata:
- Claim Count in Document: 15.0
- Percentile: 93.0
- Lexical Diversity: 1.8125
- Patent Class: 536.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14909305', '15594921', '15189159', '15602377', '14206814']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.774793788202653
- 35 USC 102 Novelty (BERT): 0.7183987743814806
- Combined Prediction Score: 0.7691542868205358
- Mean Citation Score: 610.0813919999998
- Max Citation Score: 800.1607
- Similarity Product: 785.8444607740703

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test