PATENT CLAIM ANALYSIS

Application Number: 15995135
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["436", "501000"]

Abstract:
The present invention provides a method for clinically identifying Parkinson disease with normal cognition or Parkinson disease dementia in a subject.

Claim (Index 1):
A method for clinically identifying Parkinson disease with normal cognition or Parkinson disease dementia in a subject, comprising:\n (a) detecting in vitro immunomagnetic reduction (IMR) signals of \u03b1-synuclein in a blood sample of the subject, wherein the IMR signals are produced by binding \u03b1-synuclein with magnetic nanoparticles containing antibody against \u03b1-synuclein; (b) fitting the IMR signals of \u03b1-synuclein detected in step (a) to a logistic function (I) to calculate \u03b1-synuclein's concentration in the blood sample: IMR \ue8a0 ( % ) = A - B 1 + ( \u03d5 \u03b1 - syn \u03d5 o ) \u03b3 + B , ( I ) \u2003wherein IMR (%) is the IMR signals of \u03b1-synuclein, \u03c6 \u03b1-syn  is the concentration of \u03b1-synuclein, fitting parameter A is a background value, B is a maximum value, \u03c6 o  is the concentration of \u03b1-synuclein when IMR signal equals ((A+B)/2), \u03b3 is a slope at data point \u03c6 o  of a curve where \u03c6 \u03b1-syn  is x-axis and IMR (%) is y-axis; (c) comparing \u03b1-synuclein's concentration obtained in step (b) to two cut-off values:\n wherein \u03b1-synuclein's concentrations higher than one cut-off value of 0.1 pg/ml is indicative of Parkinson disease with normal cognition, and \u03b1-synuclein's concentrations higher than the other cut-off value of 1 pg/ml is indicative of Parkinson disease dementia; and \n (d) evaluating a treatment of the subject by consulting the \u03b1-synuclein's concentration.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 94.0
- Lexical Diversity: 1.15789
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14200020', '13140699', '15135540', '13782160', '14820649']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6556394669521296
- 35 USC 102 Novelty (BERT): 0.4760760799813088
- Combined Prediction Score: 0.6376831282550476
- Mean Citation Score: 195.260388
- Max Citation Score: 234.21773
- Similarity Product: 184.6418307007528

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test