PATENT CLAIM ANALYSIS

Application Number: 16155841
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["514", "224200"]

Abstract:
Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Claim (Index 2):
The compound of  claim 1 , or a tautomer or isomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein compound is of Formula (Ia): or a tautomer or isomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein:\n W is A or AB wherein A and B are fused together; \n A is phenyl or 6-membered heteroaryl, each of which is optionally substituted with R 17a , wherein A and R 17a  together are \n and n is 0, 1, 2, 3, or 4;\n B is C 3 -C 6  cycloalkyl, 3- to 7-membered heterocyclyl, 5- to 7-membered heteroaryl, or C 6  aryl, each of which is optionally substituted with R 17b , wherein A, B, R 17a , and R 17b  together are \n and m and n are independently 0, 1, 2, 3, or 4;\n X is hydrogen or C 1 -C 6  alkyl; \n Y is N or CR 1 ; \n Z is N or CR 2 ; \n R 1  and R 2  are independently hydrogen or R 17a ; \n R 3a  and R 3b  are independently hydrogen or R 17a , or \n R 3a  and R 3b  are taken together with the carbon to which they are attached to form a C 3 -C 6  cycloalkyl; \n each R 17b  is independently oxo or R 17a , or \n any two R 17b  groups, when bound to the same carbon atom, are taken together with the carbon to which they are attached to form a C 3 -C 6  cycloalkyl; \n each R 17a  is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, \u2014CN, \u2014OR 10 , \u2014SR 10 , \u2014NR 11 R 12 , \u2014C(O)R 10 , \u2014C(O)NR 11 R 12 , \u2014OC(O)NR 11 R 12 , \u2014NR 10 C(O)R 11 , \u2014NR 10 C(O)NR 11 R 12 , \u2014S(O) 2 R 10 , \u2014NR 10 S(O) 2 R, \u2014S(O) 2 NR 11 R 12 , C 3 -C 6  cycloalkyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, C 6 -C 14  aryl, \u2014(C 1 -C 3  alkylene)CN, \u2014(C 1 -C 3  alkylene)OR 10 , \u2014(C 1 -C 3  alkylene)SR 10 , \u2014(C 1 -C 3  alkylene)NR 11 R 12 , \u2014(C 1 -C 3  alkylene)CF 3 , \u2014(C 1 -C 3  alkylene)C(O)R 10 , \u2014(C 1 -C 3  alkylene)C(O)NR 11 R 12 , \u2014(C 1 -C 3  alkylene)NR 10 C(O)R 11 , \u2014(C 1 -C 3  alkylene)NR 1 OC(O)NR 11 R 12 , \u2014(C 1 -C 3  alkylene)S(O) 2 R 10 , \u2014(C 1 -C 3  alkylene)NR 10 S(O) 2 R 11 , \u2014(C 1 -C 3  alkylene)S(O) 2 NR 11 R 12 , \u2014(C 1 -C 3  alkylene)(C 3 -C 6  cycloalkyl), \u2014(C 1 -C 3  alkylene)(3- to 12-membered heterocyclyl), \u2014(C 1 -C 3  alkylene)(5- to 10-membered heteroaryl) or \u2014(C 1 -C 3  alkylene)(C 6 -C 14  aryl), wherein each R 17a  is independently optionally substituted by halogen, oxo, \u2014OR 13 , \u2014NR 13 R 14 , \u2014C(O)R 13 , \u2014CN, \u2014(C 1 -C 3  alkylene)OR 13 , \u2014(C 1 -C 3  alkylene)NR 13 R 14 , \u2014(C 1 -C 3  alkylene)C(O)R 13 , C 3 -C 8  cycloalkyl, or C 1 -C 6  alkyl optionally substituted by oxo, \u2014OH or halogen; \n R 4  is hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, C 6 -C 14  aryl, \u2014(C 1 -C 3  alkylene)(C 3 -C 6  cycloalkyl), \u2014(C 1 -C 3  alkylene)(3- to 12-membered heterocyclyl), \u2014(C 1 -C 3  alkylene)(5- to 10-membered heteroaryl) or \u2014(C 1 -C 3  alkylene)(C 6 -C 14  aryl), wherein R 4  is independently optionally substituted by halogen, oxo, \u2014OR 13 , \u2014NR 13 R 14 , \u2014C(O)R 13 , \u2014CN, C 3 -C 8  cycloalkyl, or C 1 -C 6  alkyl optionally substituted by oxo, \u2014OH or halogen; \n R 10  is independently hydrogen, C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 6 -C 14  aryl, 5- to 6-membered heteroaryl or 3- to 6-membered heterocyclyl, wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 6 -C 14  aryl, 5- to 6-membered heteroaryl and 3- to 6-membered heterocyclyl are independently optionally substituted by halogen, oxo, \u2014CN, \u2014OR 15 , \u2014NR 15 R 16 , or C 1 -C 6  alkyl optionally substituted by halogen, \u2014OH or oxo; \n R 11  and R 12  are each independently hydrogen, C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 6 -C 14  aryl, 5- to 6-membered heteroaryl or 3- to 6-membered heterocyclyl, wherein the C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 6 -C 14  aryl, 5- to 6-membered heteroaryl and 3- to 6-membered heterocyclyl of R 11  and R 12  are independently optionally substituted by halogen, oxo, \u2014CN, \u2014OR 15 , \u2014NR 15 R 16  or C 1 -C 6  alkyl optionally substituted by halogen, \u2014OH or oxo, \n or R 11  and R 12  are taken together with the atom to which they attached to form a 3- to 6-membered heterocyclyl optionally substituted by halogen, oxo, or C 1 -C 6  alkyl optionally substituted by halogen; \n R 13  and R 14  are each independently hydrogen or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl of R 13  and R 14  are optionally substituted by halogen, \u2014OR, \u2014NR 15 R 16 , or oxo, \n or R 13  and R 14  are taken together with the atom to which they attached to form a 3- to 6-membered heterocyclyl optionally substituted by halogen, oxo or C 1 -C 6  alkyl optionally substituted by halogen or oxo; and \n R 15  and R 16  are each independently hydrogen, C 1 -C 6  alkyl optionally substituted by halogen or oxo, C 2 -C 6  alkenyl optionally substituted by halogen or oxo, or C 2 -C 6  alkynyl optionally substituted by halogen or oxo, \n or R 15  and R 16  are taken together with the atom to which they attached to form a 3- to 6-membered heterocyclyl optionally substituted by halogen, oxo or C 1 -C 6  alkyl optionally substituted by oxo or halogen.

Metadata:
- Claim Count in Document: 61.0
- Percentile: 97.0
- Lexical Diversity: 1.26087
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13406937', '13547314', '13655164', '14307680', '14748990']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.808408382301337
- 35 USC 102 Novelty (BERT): 0.5215941752050494
- Combined Prediction Score: 0.7797269615917083
- Mean Citation Score: 312.78887999999995
- Max Citation Score: 325.19232
- Similarity Product: 264.506713442688

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test