PATENT CLAIM ANALYSIS

Application Number: 15775080
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "04400A"]

Abstract:
Provided is a composition containing an agent capable of inhibiting the expression of HMGCLL1 IS3, and a method for treating or preventing a malignant tumor. The malignant tumor expresses HMGCLL1 IS3. The malignant tumors may show resistance to tyrosine kinase inhibitors. A method, composition, and kit for determining the expression level of HMGCLL1 IS3, for diagnosing drug resistance, for determining the probability of developing a malignant tumor, and for predicting prognosis of malignant tumors are provided.

Claim (Index 14):
A method selected from the following (i)-(ii):\n (i) a method for determining tyrosine kinase inhibitor resistance in a test subject, and (ii) a method for predicting prognosis of a malignant tumor in a test subject, said method comprising:\n (a) measuring an expression level of HMGCLL1 IS3 from a biological sample of the test subject who has a malignant tumor or is suspected to have a malignant tumor; and \n (b) comparing the measured expression level of HMGCLL1 IS3 of step (a) with that of a control sample of a control subject, \n wherein a higher expression level of HMGCLL1 IS3 measured in (a) than that of the control sample is an indicator of tyrosine kinase inhibitor resistance of the test subject or a poor prognosis of a malignant tumor of the test subject.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 93.0
- Lexical Diversity: 1.86957
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12708294', '13050604', '14979566', '11317516', '13809880']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7737686646523732
- 35 USC 102 Novelty (BERT): 0.5036012547720918
- Combined Prediction Score: 0.746751923664345
- Mean Citation Score: 232.853344
- Max Citation Score: 236.59807
- Similarity Product: 148.8812228923911

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test