PATENT CLAIM ANALYSIS

Application Number: 16078155
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "249000"]

Abstract:
Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

Claim (Index 1):
A compound of formula (I) wherein R is straight chain or branched alkyl having 1 to 6 carbon atoms, wherein 1 to 5 hydrogen atoms may be replaced by Hal or OH; W is CH or N; A denotes one of the following groups: X is N or CR\u2032\u2033; X 1 , X 2  is N or CR\u2032\u2033; X 3  is N or CR\u2032\u2033\u2033; X 4  is N or CR 9 ; R 9  denotes Hal, NR 3 R 4 , CHR 3 R 4 , OR 3 , CN, straight chain or branched alkyl having 1 to 12 carbon atoms, wherein 1 to 3 CH 2 -groups may be replaced by a group selected from O, NR 3 , S, SO, SO 2 , S(O)(NH), CO, COO, OCO, CONR 3 , NR 3 CO and wherein 1 to 5 hydrogen atoms may be replaced by Hal, NR 3 R 4  or NO 2 ; Y is O, S, SO or SO 2 ; R\u2032, R\u2033 denote each independently H, Hal or straight chain or branched alkyl having 1 to 12 carbon atoms; R\u2032\u2033, R\u2033\u2033 independently denote H, Hal, NR 3 R 4 , CHR 3 R 4 , OR 3 , CN, straight chain or branched alkyl having 1 to 12 carbon atoms, wherein 1 to 3 CH 2 -groups may be replaced by a group selected from O, NR 3 , S, SO, SO 2 , S(O)(NH), CO, COO, OCO, CONR 3 , NR 3 CO and wherein 1 to 5 hydrogen atoms may be replaced by Hal, NR 3 R 4  or NO 2 ; R\u2032\u2033\u2033 denotes H, Hal, NR 3 R 4 , CHR 3 R 4 , CN, straight chain or branched alkyl having 1 to 12 carbon atoms, wherein 1 to 3 CH 2 -groups may be replaced by a group selected from O, NR 3 , S, SO, SO 2 , S(O)(NH), CO, COO, OCO, CONR 3 , NR 3 CO and wherein 1 to 5 hydrogen atoms may be replaced by Hal, NR 3 R 4  or NO 2 ; R 3 , R 4  denote each independently H or a straight chain or branched alkyl group having 1 to 12 carbon atoms; Q denotes one of the following groups: Z 1  is S, O, NR 3 ; Z 2 , Z 3  independently denote CR 5 , CR 6  or N; Z 2 \u2032 is CR 5 \u2032 or N; Z 4  is N, CH, CON, COCH; Z 5  is S, O, NR 8 , SO 2 , CHR 5 ; Z 5\u2032  is S, O, NR 8 , SO 2 ; Z 6  is CH 2 , CO; s denotes 0 or 1; T is N, CH or CR 7 ; R 3 \u2032 denotes H or a straight chain or branched alkyl group having 1 to 12 carbon atoms, wherein 1 to 3 CH 2 -groups may be replaced by a group selected from SO 2 , CO, O and wherein 1 to 5 hydrogen atoms may be replaced by Hal; R 3 \u2033 denotes a straight chain or branched alkyl group having 1 to 12 carbon atoms, wherein 1 to 3 CH 2 -groups are replaced by a group selected from SO 2 , CO, O and wherein 1 to 5 hydrogen atoms may be replaced by Hal; R 5 , R 5 \u2032, R 6 , R 7  independently denote H, Hal, NR 3 R 4 , NO 2 , straight chain or branched alkyl having 1 to 12 carbon atoms, wherein 1 to 3 CH 2 -groups may be replaced by a group selected from O, NR 3 , S, SO, SO 2 , S(O)(NH), CO, COO, OCO, CONR 3 , NR 3 CO and wherein 1 to 5 hydrogen atoms may be replaced by Hal, NR 3 R 4 , NO 2 , OR 3 , Het, Ar, Cyc, or denote Ar, Het or Cyc; R 8  denotes H, methyl or straight chain or branched alkyl having 2 to 12 carbon atoms, wherein 1 to 3 CH 2 -groups may be replaced by a group selected from O, NR 3 , S, SO, SO 2 , S(O)(NH), CO, COO, OCO, CONR 3 , NR 3 CO and wherein 1 to 5 hydrogen atoms may be replaced by Hal, NR 3 R 4  or NO 2 ; Hal denotes F, Cl, Br or I; Het denotes a saturated, unsaturated or aromatic ring, being monocyclic or bicyclic or fused-bicyclic and having 3- to 8-members and containing 1 to 4 heteroatoms selected from N, O and S, which may be substituted by 1 to 3 substituents selected from R 5 , Hal and OR 3 ; Ar denotes a 6-membered carbocyclic aromatic ring or a fused or non fused bicylic aromatic ring system, which is optionally substituted by 1 to 3 substituents independently selected from R 5 , OR 3  and Hal; Cyc denotes a saturated or an unsaturated carbocyclic ring having from 3 to 8 carbon atoms which is optionally substituted by 1 to 3 substituents independently selected from R 5  or Hal or OH; m and n denote independently from one another 0, 1, 2 or 3 and pharmaceutically usable derivatives, solvates, salts, tautomers, enantiomers, racemates and stereoisomers thereof, including mixtures thereof in all ratios and compounds of formula I, wherein one or more H atoms are replaced by D (deuterium).

Metadata:
- Claim Count in Document: 23.0
- Percentile: 96.0
- Lexical Diversity: 1.27273
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14502213', '14131471', '14775134', '15830675', '13515598']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8055814261328982
- 35 USC 102 Novelty (BERT): 0.5450450950672823
- Combined Prediction Score: 0.7795277930263367
- Mean Citation Score: 355.667998
- Max Citation Score: 387.89282
- Similarity Product: 304.1445159845805

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test