PATENT CLAIM ANALYSIS

Application Number: 15914016
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "210210"]

Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Claim (Index 1):
A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is selected from the group consisting of:\n 1) Hydrogen; \n 2) Halogen; \n 3) CN; \n 4) Optionally substituted \u2014C 1 -C 8  alkyl; and \n 5) Optionally substituted \u2014C 1 -C 8  alkyl \u2014O\u2014R 11 ; \n \n R 2  and R 5  are each independently selected from the group consisting of:\n 1) Hydrogen; and \n 2) Optionally substituted \u2014C 1 -C 8  alkyl; \n \n A is selected from the group consisting of:\n 1) Optionally substituted \u2014C 3 -C 12  cycloalkyl; \n 2) Optionally substituted \u2014C 3 -C 12  cycloalkenyl; \n 3) Optionally substituted 3- to 12-membered heterocycloalkyl; \n 4) Optionally substituted aryl; and \n 5) Optionally substituted heteroaryl; \n \n R 3  is hydrogen or R 11 ; \n R 4  is selected from the group consisting of:\n 1) Optionally substituted \u2014C 3 -C 12  cycloalkyl; \n 2) Optionally substituted \u2014C 3 -C 12  cycloalkenyl; \n 3) Optionally substituted 3- to 12-membered heterocyclyl; \n 4) Optionally substituted aryl; \n 5) Optionally substituted heteroaryl; \n 6) Optionally substituted aryl-O\u2014; \n 7) Optionally substituted heteroaryl-O; \n 8) Optionally substituted aryl-C 1 -C 4 -alkyl; and \n 9) Optionally substituted heteroaryl-C 1 -C 4 -alkyl; \n \n each R 6  is the same or different and independently selected from hydrogen, halogen, hydroxyl, protected hydroxyl, cyano, amino, protected amino, nitro, optionally substituted \u2014C 1 -C 8  alkyl, optionally substituted \u2014C 1 -C 8  alkoxy, optionally substituted \u2014NHC 1 -C 8  alkyl, optionally substituted \u2014S\u2014(\u2014C 1 -C 8  alkyl), optionally substituted \u2014SO 2 \u2014(\u2014C 1 -C 8  alkyl), -optionally substituted \u2014SO 2 \u2014NH\u2014(\u2014C 1 -C 8  alkyl), optionally substituted \u2014NH\u2014SO 2 \u2014(\u2014C 1 -C 8  alkyl), \u2014CO 2 R 12 , \u2014NR 13 R 14 , and \u2014CO\u2014NR 13 R 14 ; R 11  and R 12  are each independently is selected from the group consisting of:\n 1) Optionally substituted \u2014C 1 -C 8  alkyl; \n 2) Optionally substituted \u2014C 2 -C 8  alkenyl; \n 3) Optionally substituted \u2014C 2 -C 8  alkynyl; \n 4) Optionally substituted \u2014C 3 -C 8  cycloalkyl; \n 5) Optionally substituted \u2014C 3 -C 8  cycloalkenyl; \n 6) Optionally substituted 3- to 8-membered heterocycloalkyl; \n 7) Optionally substituted aryl; and \n 8) Optionally substituted heteroaryl; \n R 13  and R 14  are each independently selected from hydrogen, optionally substituted \u2014C 1 -C 8 -alkyl, optionally substituted \u2014C 2 -C 8 -alkenyl, optionally substituted \u2014C 2 -C 8 -alkynyl; optionally substituted \u2014C 3 -C 8 -cycloalkyl, \u2014C(O)R 12 , \u2014S(O) 2 R 12 , and \u2014S(O) 2 NHR 12 , and optionally substituted \u2014C 1 -C 8 -alkoxy; alternatively, R 13  and R 14  are taken together with the nitrogen they attached to form a heterocyclic ring; and n is 0, 1, 2, 3 or 4.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 90.0
- Lexical Diversity: 1.63265
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15216119', '15863216', '10400387', '13905410', '15645701']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7951582702792139
- 35 USC 102 Novelty (BERT): 0.5568716871885954
- Combined Prediction Score: 0.771329611970152
- Mean Citation Score: 335.19447599999995
- Max Citation Score: 406.19183
- Similarity Product: 402.34263271456354

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test