PATENT CLAIM ANALYSIS

Application Number: 16042004
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-07
Patent Classification: ["506", "001000"]

Abstract:
A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is exhibited at the surface of the host cell. Such a vector allows for the display of complex biologically active polypeptides, e.g., biologically active multi-chain polypeptides such as immunoglobulin Fab fragments. The present invention describes and enables the successful display of a multi-chain polypeptide on the surface of a eukaryotic host cell. Preferred vectors are described for expressing the chains of a multi-chain polypeptide in a host cell separately and independently (e.g., under separate vector control elements, and/or on separate expression vectors, thus forming a matched vector set). The use of such matched vector sets provides flexibility and versatility in the generation of eukaryotic display libraries, for example the ability to generate and to display multi-chain polypeptides by combining and recombining vectors that express variegations of the individual chains of a multi-chain polypeptide. Entire repertoires of novel chain combinations can be devised using such vector sets.

Claim (Index 105):
The yeast hose cell of  claim 104 , wherein the yeast host cell is Saccharomyces cerevisiae.

Metadata:
- Claim Count in Document: 46.0
- Percentile: 95.0
- Lexical Diversity: 2.07692
- Patent Class: 506.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14718656', '15377846', '13170362', '13937915', '12625337']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7311349467332712
- 35 USC 102 Novelty (BERT): 0.6501087426332262
- Combined Prediction Score: 0.7230323263232667
- Mean Citation Score: 740.316716
- Max Citation Score: 750.62445
- Similarity Product: 563.6262942886412

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test