PATENT CLAIM ANALYSIS

Application Number: 15748268
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-01
Patent Classification: ["424", "130100"]

Abstract:
An antibody production process in mammalian cells in which engineered unpaired cysteine residues are post-translationally modified and capped with particular chemical entities, which capped antibodies are well suited to further site-specific conjugation steps to form antibody-drug conjugates (ADCs) or protein drug conjugates; ADCs produced using these capped antibodies including in particular ADCs formed by the selective reduction of the capped antibodies' cysteine residues, and ADCs formed using chemical handles such as aldehyde/azide/alkyne biorthogonal groups, which permit additional drug conjugation chemistry; and uncapped antibodies produced by cells in low cysteine, cysteine and glutathione media, and ADCs produced via direct conjugation to these uncapped antibodies.

Claim (Index 4):
A method of producing an antibody drug conjugate (ADC) or a protein conjugate comprising the steps:\n (a) producing a capped antibody in a cell culture, wherein one or more unpaired cysteine residues on said antibody are covalently bonded through sulfur bonds to one or more predetermined capping moieties; (b) exposing said capped antibody to a reducing agent capable of removing said capping moieties from said antibody without reducing antibody inter-chain sulfur bonds; and (c) without introducing an oxidizing agent, conjugating one or more reduced sulfur bonds on said antibody to a payload via a linking moiety.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 86.0
- Lexical Diversity: 1.70149
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15356750', '14908492', '15117254', '15512030', '11255528']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7322332871959251
- 35 USC 102 Novelty (BERT): 0.530354371024049
- Combined Prediction Score: 0.7120453955787375
- Mean Citation Score: 288.46417600000007
- Max Citation Score: 361.83197
- Similarity Product: 264.3432870052153

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test