PATENT CLAIM ANALYSIS

Application Number: 15894252
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["435", "201000"]

Abstract:
Provided herein is an α-fucosidase that can cleave a conjugate comprising an N-glycan and a label where the label is added by amine reactive chemistry. The α-fucosidase also has an accelerated reaction time using Schiff base labeled N-glycans compared with bovine kidney fucosidase. A reaction mix, enzyme mix and kit comprising the α-fucosidase are provided, as well as a method for analyzing glycoproteins. The α-fucosidase finds particular use in analyzing the N-glycans of therapeutic glycoproteins.

Claim (Index 16):
A kit, comprising:\n (a) an \u03b1-fucosidase having an amino acid sequence that is at least 90% identical to amino acids 23-269 of sequence of SEQ ID NO:1; and (b) one or more exoglycosidases selected from the group consisting of:\n \u03b12-3 neuraminidase S; \n \u03b12-3,6,8,9 neuraminidase A; \n \u03b11-3,4,6 galactosidase; \n \u03b21-4 galactosidase; \n \u03b2-N-acetylglucosaminidase S; and \n \u03b11-2,3,6 mannosidase.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 88.0
- Lexical Diversity: 1.42105
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12595925', '13720192', '15320911', '14569501', '15532271']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5826406075893382
- 35 USC 102 Novelty (BERT): 0.5291232033801999
- Combined Prediction Score: 0.5772888671684244
- Mean Citation Score: 304.1448660000001
- Max Citation Score: 346.10013
- Similarity Product: 264.3655633310616

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test