PATENT CLAIM ANALYSIS

Application Number: 16322391
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-06
Patent Classification: ["546", "209000"]

Abstract:
The present invention relates to chimeric (including bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including metastatic and other cancers where cancer cells exhibit overexpression (heightened expression) of cell surface urokinase-type plasminogen activator receptor (urokinase receptor) compared to normal (non-cancerous) cells. The compounds bind to the urokinase-type plasminogen activator receptor (uPAR) on the surface of a cancer cell, including a metastatic cancer cell, and consequently recruit native antibodies of the patient or subject where the antibodies can selectively degrade and/or deactivate targeted cancer cells through antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) against a large number and variety of cancers, thus providing cancer cell death and an inhibition of growth, elaboration and/or metastasis of the cancer, including remission and cure of the patient's cancer.

Claim (Index 6):
A compound according to  claim 1  wherein LIN is a group according to the chemical formula: where Z and Z\u2032 are each independently a bond, \u2014(CH 2 ) i \u2014O, \u2014(CH 2 ) i \u2014S, \u2014(CH 2 ) i \u2014N\u2014R, wherein said (CH 2 ) i group, if present in Z or Z\u2032,, is bonded to a connector (CT), an alternative linker, A B M and/or UPAR B M; Each R is H, or a C 1 -C  3  alkyl or alkanol group; Each R 2  is independently H or a C 1 -C 3  alkyl group; Each Y is independently a bond, O, S or N\u2014R; Each i is independently 0 to 100; D is or\n a bond, with the proviso that Z, Z\u2032 and D are not each simultaneously bonds; \n j is 1 to 100, m\u2032 is 1 to 100; \n n is 1 to 100; \n X 1  is O, S or N\u2014R; and \n R is as described above.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 99.0
- Lexical Diversity: 1.94048
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15890040', '15374272', '14397995', '14480204', '13173480']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7406857330001513
- 35 USC 102 Novelty (BERT): 0.5050771867377015
- Combined Prediction Score: 0.7171248783739063
- Mean Citation Score: 220.170034
- Max Citation Score: 282.3902
- Similarity Product: 246.08666946733

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test