PATENT CLAIM ANALYSIS

Application Number: 16111700
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "256000"]

Abstract:
The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.

Claim (Index 1):
A method for treating a disease chosen from depression, depression secondary to illness, major depressive disorder, multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, transverse myelitis, amyotrophic lateral sclerosis, and arteriosclerotic dementia in a subject in need thereof, comprising the administration to the subject a compound of structural Formula XI: and/or a salt thereof, wherein:\n Y is C(R 2 ) 2 ; \n X is chosen from CH and N; \n n is an integer chosen from 0, 1 or 2; \n each R 2  is independently chosen from hydrogen and lower alkyl; \n R 3  is chosen from methyl, ethyl, trifluoromethyl, and cyclopropyl; \n R 4  is chosen from hydrogen and ethyl; \n R 5  is either benzoxaborole, or is chosen from phenyl and pyridinyl, either of which is para-substituted with a substituent of the form R 8 -R 9 -(R 10 ) a (R 10 ) b , and is optionally substituted with a substituent R 13 ; \n R 8  is chosen from a bond and lower alkyl; \n R 9  is chosen from halogen, lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxy, lower haloalkoxy, cyano, \u2014C(O)N\u2014, S(O) 2 \u2014, B(OH) 2 , 5-6 membered monocyclic heterocycloalkyl, and 5-6 membered monocyclic heteroaryl; \n (R 10 ) a  and (R 10 ) b  are each independently chosen from null, hydrogen, halogen, trifluoromethyl, trifluoromethoxy, hydroxyl, lower hydroxyalkyl, cyano, oxo, lower alkyl, C(O)OH, and C(O)O lower alkyl; \n R 13  is chosen from halogen, hydroxy, lower alkyl, trifluoromethyl, lower alkoxy, trifluoromethoxy, NH 2 , and cyano; \n R 6  is chosen from 3-chlorophenyl, 5-chloro-2-thienyl, cyclopentyl optionally substituted with one or two R 14 , and cyclopentoxy optionally substituted with one or two R 14 ; and \n each R 14  is independently chosen from halogen, hydroxy, lower alkyl, trifluoromethyl, lower alkoxy, trifluoromethoxy, NH 2 , and cyano.

Metadata:
- Claim Count in Document: 113.0
- Percentile: 96.0
- Lexical Diversity: 1.15625
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15680842', '14938544', '14349688', '10578594', '12275165']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7662514356655277
- 35 USC 102 Novelty (BERT): 0.5642864844153049
- Combined Prediction Score: 0.7460549405405055
- Mean Citation Score: 375.501834
- Max Citation Score: 434.56226
- Similarity Product: 370.952561437056

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test