PATENT CLAIM ANALYSIS

Application Number: 16420385
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-09
Patent Classification: ["435", "007920"]

Abstract:
The present disclosure relates to a method for diagnosing and/or grading diastolic dysfunction or at least one structural or functional abnormality associated with diastolic dysfunction. The method involves measuring the level of IGFBP7 (Insulin like growth factor binding protein 7) and, optionally, the level of at least one further marker in a patient suffering from heart failure, and comparing the level to a reference level. Further envisaged is a method of monitoring diastolic function in a patient suffering from heart failure. Also encompassed by the present disclosure are kits and devices adapted to carry out the method of the present invention.

Claim (Index 1):
A method for monitoring diastolic function and/or at least one parameter of diastolic function, said method comprising the steps of\n a) measuring the level of the biomarker IGFBP7 (Insulin like growth factor binding protein 7) and, optionally, at least one further biomarker selected from the group consisting of Osteopontin, a cardiac Troponin, a BNP-type peptide, in particular NT-proBNP, Endostatin, Mimecan, uric acid, and GDF15 (Growth differentiation factor 15) in first and in a second sample from a patient suffering from heart failure, said patient having a reduced left ventricular ejection fraction (LVEF), wherein said second sample has been obtained after the first sample, and b) comparing the level of the biomarker IGFBP7, and optionally the level of said at least one further biomarker measured in the second sample to the level in the first sample, wherein the at least one parameter of diastolic function is selected from the group consisting of left atrial size, left atrial superior-inferior diameter, left atrial volume index, E peak velocity, A peak velocity, transmitral E/A ratio, mitral inflow E velocity to tissue Doppler E\u2032 velocity ratio, E\u2032/A\u2032 ratio, pulmonary vein systolic peak velocity, pulmonary vein diastolic peak velocity, pulmonary vein systolic/diastolic ratio, increased right ventricular area, right ventricular systolic pressure (RVSP), right ventricular dilation, right atrium size, the right atrial superior-inferior diameter, mitral regurgitation and tricuspid regurgitation.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 100.0
- Lexical Diversity: 1.66667
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15274533', '15581587', '14818768', '15220555', '12309803']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5304168391924556
- 35 USC 102 Novelty (BERT): 0.6329635849323624
- Combined Prediction Score: 0.5406715137664463
- Mean Citation Score: 325.089296
- Max Citation Score: 634.2080000000002
- Similarity Product: 526.5946797294619

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test