PATENT CLAIM ANALYSIS

Application Number: 15976279
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "304000"]

Abstract:
The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.

Claim (Index 1):
A liquid storage-stable low-dose ophthalmic atropine composition, consisting essentially of:\n an aqueous solution comprising a buffer, a tonicity agent, a chelator, a viscosity modifier, and atropine or a pharmaceutically acceptable salt thereof; wherein the atropine or the pharmaceutically acceptable salt thereof is present in the ophthalmic atropine composition in an amount of equal or less than 0.05 wt %; wherein the buffer has a concentration of equal or less than 75 mM, and wherein the ophthalmic atropine composition has a pH of between 5.0 and 6.0; and wherein the ophthalmic atropine composition is formulated such that after storage over at least two months at 25\u00b0 C. and 60% relative humidity equal or less than 0.35% tropic acid is formed from degradation of the atropine.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.26667
- Patent Class: 514.0
- Transitional Phrase Type: half
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15895933', '14726139', '15661816', '15208537', '15949736']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7997424330298264
- 35 USC 102 Novelty (BERT): 0.5111603169275016
- Combined Prediction Score: 0.7708842214195939
- Mean Citation Score: 262.361012
- Max Citation Score: 278.69492
- Similarity Product: 199.63184862616785

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test