PATENT CLAIM ANALYSIS

Application Number: 15770138
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "394000"]

Abstract:
The invention provides a pharmaceutical composition for injection comprising a NL-101 type compound and a preparation method thereof. The composition uses the NL-101 type compound as an active pharmaceutical ingredient, and the stability of the NL-101 type compound is improved by adding a chloride-containing stabilizing agent or using a co-solvent containing hydrochloric acid, so that the formulation can be stably produced and meet the requirements for clinical safe use.

Claim (Index 1):
A pharmaceutical composition, characterized in comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and a stabilizing agent, wherein the stabilizing agent is a pharmaceutically acceptable chloride-containing compound, wherein, m is an integer selected from 5-16; Z is absent or selected from C(RaRb), O, S, C(O), N(Ra), SO 2 , OC(O), C(O)O, OSO 2 , S(O 2 )O, C(O)S, SC(O), C(O)C(O), C(O)N(Ra), N(Ra)C(O), S(O 2 )N(Ra), N(Ra)S(O 2 ), OC(O)N(Ra), N(Ra)C(O)O, N(Ra)C(O)S, or N(Ra)C(O)N(Rb), wherein Ra and Rb are each independently H, alkyl, alkenyl or alkynyl; X 1  and X 2  are each independently halogen or OSO 2 Rc, wherein Rc is alkyl, alkenyl or alkynyl; Q is selected from cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl or heteroaryl, optionally substituted with one or more substituents selected from alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, halogen, nitro, oxo, \u2014C\u2550NH, cyano, alkyl-Rd, ORd, OC(O)Rd, OC(O)ORd, OC(O)SRd, SRd, C(O)Rd, C(O)ORd, C(O)SRd, C(O)NReRf, SORd, SO 2 Rd, NReRf, or N(Re)C(O)Rf, wherein Rd, Re, and Rf are each independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halogen, cyano, amine, nitro, hydroxyl, or alkoxy.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 91.0
- Lexical Diversity: 1.43137
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14345562', '13746999', '12762025', '14538464', '14030692']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.75309332800649
- 35 USC 102 Novelty (BERT): 0.4922534401627129
- Combined Prediction Score: 0.7270093392221123
- Mean Citation Score: 226.71752
- Max Citation Score: 266.564
- Similarity Product: 233.82824271845817

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test