PATENT CLAIM ANALYSIS

Application Number: 16005390
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-03
Patent Classification: ["435", "007320"]

Abstract:
The present invention relates to composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence that encodes therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.

Claim (Index 46):
A method of reducing tolerance to a therapeutic agent in a subject in need thereof comprising administering to the subject a composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence, the second nucleic acid encoding at least one therapeutic agent comprising a cellular toxin, wherein the non-constitutive promoter is an exogenous inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 94.0
- Lexical Diversity: 2.13043
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14428341', '14274724', '13500360', '14221190', '15160405']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5017619697735868
- 35 USC 102 Novelty (BERT): 0.6054145174612361
- Combined Prediction Score: 0.5121272245423517
- Mean Citation Score: 314.193
- Max Citation Score: 619.1416
- Similarity Product: 435.9804905891418

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test