PATENT CLAIM ANALYSIS

Application Number: 15862922
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["424", "489000"]

Abstract:
The present disclosure provides ready-to-use, oil/water emulsion compositions with mean droplet size (intensity-average, nm) of 100-500 nm, where the oil phase comprises clopidogrel free base dispersed in pharmaceutical acceptable oil(s). The emulsion uses clopidogrel free base or premix of clopidogrel free base in oil(s) as the starting materials and may also contain one or more excipients such as surfactant and or co-surfactant, osmotic agent, pH adjustment agent, antioxidant, preservative, sweetener, and/or suspending agent, etc.

Claim (Index 1):
A method to make a stable pharmaceutical oil/water emulsion composition with nanosized oil droplets for parenteral or oral administration, said method comprising the steps of:\n a) preparing an oil phase comprising clopidogrel by dispersing clopidogrel free base in an oil carrier; b) preparing an aqueous phase comprising water and a pH adjustment agent; c) incorporating a surfactant or optionally a co-surfactant in the oil phase or in the aqueous phase; d) dispersing the oil phase in the aqueous phase to form a coarse emulsion and adjusting pH to about 9; e) forming a final emulsion by sonicating or high pressure homogenizing the emulsion of step d), and adjusting pH to between 5.5 and 10; f) filtrating the final emulsion; and g) controlling product bioburden or sterility by aseptic process or terminal sterilization.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 86.0
- Lexical Diversity: 1.59322
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14174351', '14623150', '15454967', '12597908', '11738444']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6835194494126645
- 35 USC 102 Novelty (BERT): 0.5476944459994504
- Combined Prediction Score: 0.6699369490713432
- Mean Citation Score: 261.730012
- Max Citation Score: 393.54953
- Similarity Product: 300.2048273798537

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test