PATENT CLAIM ANALYSIS

Application Number: 16181628
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["424", "001650"]

Abstract:
Among the various aspects of the present disclosure is the provision of compositions and methods for imaging and treating subjects with amyloidosis or multiple myeloma with or without amyloidosis.

Claim (Index 10):
The method of  claim 9  comprising amplifying the LC amyloid, wherein amplifying LC amyloid comprises:\n (i) receiving a biological sample from a subject; \n (ii) (A) having performed isolating light chain (LC) aggregates from the biological sample, resulting in isolates; incubating the isolates in a fibrillation buffer; providing rare AL amyloid particles to seed the amplification; creating a seed by amyloid fragmentation; and catalyzing amyloid formation; or\n (B) having performed providing a fixed amount of recombinantly expressed monomeric LC, adding the fixed amount of recombinantly expressed monomeric LC as a substrate to seeds from the biological sample, and amplifying the monomeric LC, resulting in amyloid; and \n \n (iii) having performed quantifying LC amyloid by determining lag time (t lag ) and from imaging agent fluorescence amplitude and comparing to a reference.

Metadata:
- Claim Count in Document: 49.0
- Percentile: 98.0
- Lexical Diversity: 1.30435
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13314160', '15026545', '12811049', '15552614', '15258883']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6884256206453413
- 35 USC 102 Novelty (BERT): 0.4773457386469619
- Combined Prediction Score: 0.6673176324455034
- Mean Citation Score: 167.89954399999996
- Max Citation Score: 173.50372
- Similarity Product: 126.23518068892956

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test