PATENT CLAIM ANALYSIS

Application Number: 15954450
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["800", "018000"]

Abstract:
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.

Claim (Index 68):
A method of engrafting a genetically modified, immunodeficient mouse, comprising: transplanting a population of cells comprising human hematopoietic cells into the genetically modified mouse, wherein the genetically modified mouse comprises\n a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human SIRP\u03b1 protein and is operably linked to a SIRP\u03b1 gene promoter; and a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human IL-15 protein and is operably linked to an IL-15 gene promoter, wherein the genetically modified mouse expresses the human SIRP\u03b1 protein and the human IL-15 protein.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 91.0
- Lexical Diversity: 2.25
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15097239', '14715446', '14420318', '15263916', '15866632']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6126766720813214
- 35 USC 102 Novelty (BERT): 0.6813359913487392
- Combined Prediction Score: 0.6195426040080632
- Mean Citation Score: 497.971382
- Max Citation Score: 735.2370599999997
- Similarity Product: 695.7269799808646

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test