PATENT CLAIM ANALYSIS

Application Number: 15980478
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["530", "330000"]

Abstract:
Methods of making copolymers are described.

Claim (Index 2):
A method for preparing a composition comprising purified glatiramer acetate having a pyroglutamate concentration of 2000-7000 ppm and a Mp of 5000-9000 Da, comprising:\n polymerizing N-carboxy anhydrides of L-alanine, benzyl-protected L-glutamic acid, trifluoroacetic acid (TFA) protected L-lysine and L-tyrosine to generate a protected copolymer (Intermediate-1); treating the Intermediate-1 with HBr and acetic acid to partially depolymerize the protected copolymer and deprotect benzyl-protected L-glutamic acid thereby generating a partially depolymerized product; treating the partially depolymerized product with piperidine to deprotect TFA-protected lysines thereby generating glatiramer acetate; and purifying the glatiramer acetate to create purified glatiramer acetate having a pyro-Glu concentration of 2000-7000 ppm and a Mp of 5000-9000 Da, wherein the amount of water present during the entirety of the depolymerization reaction is controlled to be within 5-25% weight/weight against intermediate-1 present at the beginning of the depolymerization reaction.

Metadata:
- Claim Count in Document: 105.0
- Percentile: 93.0
- Lexical Diversity: 1.0
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12754344', '13187243', '12408058', '14019119', '14795867']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.731653132520971
- 35 USC 102 Novelty (BERT): 0.6579899633040532
- Combined Prediction Score: 0.7242868155992792
- Mean Citation Score: 493.28149600000006
- Max Citation Score: 635.2154
- Similarity Product: 628.7915796926857

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test