PATENT CLAIM ANALYSIS

Application Number: 15956168
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["544", "405000"]

Abstract:
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R 1 , R 2 , R 3 , R 4 , R 5 , R a , R b , n, m, p and q are as defined herein, which are active as modulators of retinoid-related Sorphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Claim (Index 57):
A method of treating a ROR\u03b3t mediated disease, disorder, syndrome, or condition in a subject comprising administering an effective amount of a compound of formula (I) or a tautomer thereof, stereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein ring A is selected from ring B is selected from C 3-6 cycloalkyl, C 6-14 aryl, 3-15 membered heterocyclyl and 5 to 14 membered heteroaryl; L is absent or is  y *-X\u2014(CR x R y ) t -* z ; X is selected from O, NR x1  and each of x, y and z represents a point of attachment; R 1  is selected from hydroxyl, C 1-8 alkyl and C 1-8 alkoxy; each occurrence of R 2  is independently selected from cyano, halogen, hydroxyl, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkoxyC 1-8 alkyl, haloC 1-8 alkyl, haloC 1-8 alkoxy, hydroxyC 1-8 alkyl, C(O)C 1-8 alkyl, C 3-6 cycloalkyl, C(O)C 3-6 cycloalkyl and 3 to 15 membered heterocyclic ring; each occurrence of R 3  is independently selected from halogen, cyano, \u2014C 1-8 alkyl, haloC 1-8 alkyl and C 3-6 cycloalkyl; each occurrence of R 4  is independently selected from halogen, cyano, \u2014C 1-8 alkyl, haloC 1-8 alkyl and C 3-6 cycloalkyl; each occurrence of R 5  is independently selected from halogen, cyano, \u2014C 1-8 alkyl, haloC 1-8 alkyl and C 3-6 cycloalkyl; R a  and R b , which may be the same or different, are each independently selected from hydrogen and C 1-8 alkyl; each occurrence of R x  and R y  are independently selected from hydrogen, C 1-8 alkyl and hydroxyC 1-8 alkyl; or R x  and R y  together with the carbon atom to which they are attached, form a 3 to 6 membered cycloalkyl ring; R x1  is selected from hydrogen or C 1-8 alkyl; \u2018n\u2019 is 0, 1, 2 or 3; \u2018m\u2019 is 0, 1 or 2; \u2018p\u2019 is 0, 1 or 2; \u2018q\u2019 is 0, 1, 2 or 3 and \u2018t\u2019 is 0, 1, 2 or 3.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 91.0
- Lexical Diversity: 1.67089
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15318513', '15754037', '14778892', '15103658', '15182231']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7631236771016453
- 35 USC 102 Novelty (BERT): 0.5819969310414895
- Combined Prediction Score: 0.7450110024956298
- Mean Citation Score: 395.299002
- Max Citation Score: 494.7726
- Similarity Product: 416.1492119829655

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test