PATENT CLAIM ANALYSIS

Application Number: 15757162
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["546", "022000"]

Abstract:
Various fentanyl derivatives are described. The derivatives exhibit high binding affinity to opioid receptors, but also have decreased blood brain permeability as compared to standard fentanyl. This, the resulting derivatives can be less addictive than standard fentanyl. Methods of making such derivatives are also disclosed in this document.

Claim (Index 23):
A compound according to Formula IIa or Formula IIb: wherein:\n each R 1  is independently selected from the group consisting of halo, hydroxyl, lower alkyl, amino, carboxyl, and trifluoromethyl; \n n is 0, 1 or 2; \n L is a linking group; \n R 3  is selected from the group consisting of:\n (a) \u2014(CH 2 ) e \u2014Y, \n (b) \u2014(CH 2 ) f \u2014CR 31 R 32 \u2014(CH 2 ) g \u2014Y, and \n (c) \u2014X 1 \u2014X 2 \u2014Z, \n in which:\n e is 1 to 6; f is 1 to 4; g is 1 to 4; \n R 31  is OH or NH 2 ; R 32  is H or lower alkyl, or alternatively R 31  and R 32  are taken together with the carbon to which they are attached to form a 4- to 6-membered ring having from 0 to 2 heteroatom ring members; \n X 1  is selected \u2014C(\u2550O)\u2014 or \u2014(CH 2 ) p \u2014 wherein p is 1 to 8; \n X 2  is selected from the group consisting of \u2014S\u2014, \u2014O\u2014, and \u2014NH\u2014; \n Y is selected from the group consisting of H, OH, halo, \u2014NR 2 , \u2014S(\u2550O)CH 3 , \u2014SO 2 \u2014CH 3 , \u2014SO 2 NR 2 , \u2014PO 3 R 2 , ammonium, phosphonium, sulfonium, guaninidinium, sulfate, phosphate, carboxylate, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, heterocyclic alkyl, oligomer, polymer, and a zwitterionic group; \n Z is either (a) selected from the group consisting of H, amino, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, oligomer and a polymer, or (b) a group of the formula \u2014(CH 2 ) h \u2014Z 1 , wherein h is a number from 1 to 6 and Z 1  is selected from the group consisting of OH, halo, \u2014NR 2 , \u2014S(\u2550O)CH 3 , \u2014SO 2 \u2014CH 3 , \u2014SO 2 NR 2 , \u2014PO 3 R 2 , ammonium, phosphonium, sulfonium, guaninidinium, sulfate, phosphate, carboxylate, pyridinium, aryl, heteroaryl, heterocyclic alkyl and a zwitterionic group; and \n \n \n each R is independently selected from H and methyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.31707
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14967896', '14591290', '12743632', '13699173', '14416529']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.766616671479524
- 35 USC 102 Novelty (BERT): 0.4875444974556872
- Combined Prediction Score: 0.7387094540771403
- Mean Citation Score: 197.341536
- Max Citation Score: 201.80441
- Similarity Product: 148.15031568583726

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test