PATENT CLAIM ANALYSIS

Application Number: 16016300
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "363000"]

Abstract:
Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders or other diseases and disorders.

Claim (Index 15):
A method of treating constipation, comprising administering to a subject in need thereof a therapeutically effective amount a compound of structural Formula (I): or a pharmaceutically acceptable salt thereof,\n wherein: \n Ar is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; \n L 1  and L 2  are independently substituted or unsubstituted C 1 -C 3  alkylene; \n n1, n2, n3, n4 and n5 are independently an integer from 0 to 4; \n m1, m2, m3, m4, m5, v1, v2, v3, v4 and v5 are independently 1 or 2; \n R 1  is hydrogen, halogen, \u2014CX 1.1 3 , \u2014CHX 1.1 2 , \u2014CH 2 X 1.1 , \u2014CN, \u2014SO n1 R 1A , \u2014SO v1 NR 1B R 1C , \u2014NHNR 1B R 1C , \u2014ONR 1B R 1C , \u2014NHC(O)NHNR 1B R 1C , \u2014NHC(O)NR 1B R 1C , \u2014N(O) m1 , \u2014NR 1B R 1C , \u2014C(O)R 1D , \u2014C(O)OR 1D , \u2014C(O)NR 1B R 1C , \u2014OR 1A , \u2014NR 1B SO 2 R 1A , \u2014NR 1B C(O)R 1D , \u2014NR 1B C(O)OR 1D , \u2014NR 1B OR 1D , \u2014OCX 1.1 3 , \u2014OCHX 1.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 2  is hydrogen, halogen, \u2014CX 2.1 3 , \u2014CHX 2.1 2 , \u2014CH 2 X 2.1 , \u2014CN, \u2014SO n2 R 2A , \u2014SO v2 NR 2B R 2C , \u2014NHNR 2B R 2C , \u2014ONR 2B R 2C , \u2014NHC(O)NHNR 2B R 2C , \u2014NHC(O)NR 2B R 2C , \u2014N(O) m2 , \u2014NR 2B R 2C , \u2014C(O)R 2D , \u2014C(O)OR 2D , \u2014C(O)NR 2B R 2C , \u2014OR 2A , \u2014NR 2B SO 2 R 2A , \u2014NR 2B C(O)R 2D , \u2014NR 2B C(O)OR 2D , \u2014NR 2B OR 2D , \u2014OCX 2.1 3 , \u2014OCHX 2.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 3  is hydrogen, halogen, \u2014CX 3.1 3 , \u2014CHX 3.1 2 , \u2014CH 2 X 3.1 , \u2014CN, \u2014SO n3 R 3A , \u2014SO v3 NR 3B R 3C , \u2014NHNR 3B R 3C , \u2014ONR 3B R 3C , \u2014NHC(O)NHNR 3B R 3C , \u2014NHC(O)NR 3B R 3C , \u2014N(O) m3 , \u2014NR 3B R 3C , \u2014C(O)R 3D , \u2014C(O)OR 3D , \u2014C(O)NR 3B R 3C , \u2014OR 3A , \u2014NR 3B SO 2 R 3A , \u2014NR 3B C(O)R 3D D, \u2014NR 3B C(O)OR 3D , \u2014NR 3B OR 3D , \u2014OCX 3.1 3 , \u2014OCHX 3.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 4  is hydrogen, halogen, \u2014CX 4.1 3 , \u2014CHX 4.1 2 , \u2014CH 2 X 4.1 , \u2014CN, \u2014SO n4 R 4A , \u2014SO 4 NR 4B R 4C , \u2014NHNR 4B R 4C , \u2014ONR 4B R 4C , \u2014NHC(O)NHNR 4B R 4C , \u2014NHC(O)NR 4B R 4C , \u2014N(O) m4 , \u2014NR 4B R 4C , \u2014C(O)R 4D , \u2014C(O)OR 4D , \u2014C(O)NR 4B R 4C , \u2014OR 4A , \u2014NR 4B SO 2 R 4A , \u2014NR 4B C(O)R 4D , \u2014NR 4B C(O)OR 4D , \u2014NR 4B OR 4D , \u2014OCX 4.1 3 , \u2014OCHX 4.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 5  is hydrogen, halogen, \u2014CX 5.1 3 , \u2014CHX 5.1 2 , \u2014CH 2 X 5.1 , \u2014CN, \u2014SO n5 R 5A , \u2014SO v5 NR 5B R 5C , \u2014NHNR 5B R 5C , \u2014ONR 5B R 5C , \u2014NHC(O)NHNR 5B R 5C , \u2014NHC(O)NR 5B R 5C , \u2014N(O) m5 , \u2014NR 5B R 5C , \u2014C(O)R 5D , \u2014C(O)OR 5D , \u2014C(O)NR 5B R 5C , \u2014OR 5A , \u2014NR 5B SO 2 R 5A , \u2014NR 5B C(O)R 5D , \u2014NR 5B C(O)OR 5D , \u2014NR 5B OR 5D , \u2014OCX 5.1 3 , \u2014OCHX 5.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 1A , R 1B , R 1C , R 1D , R 2A , R 2B , R 2C , R 2D , R 3A , R 3B , R 3C , R 3D , R 4A , R 4B , R 4C , R 4D , R 5A , R 5B , R 5C  and R 5D  are independently hydrogen, halogen, \u2014CF 3 , \u2014CCl 3 , \u2014CBr 3 , \u2014CI 3 , \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 3 H, \u2014SO 4 H, \u2014SO 2 NH 2 , \u2014NHNH 2 , \u2014ONH 2 , \u2014NHC(O)NHNH 2 , \u2014NHC(O)NH 2 , \u2014NHSO 2 H, \u2014NHC(O)H, \u2014NHC(O)\u2014OH, \u2014NHOH, \u2014OCF 3 , \u2014OCCl 3 , \u2014OCBr 3 , \u2014OCI 3 , \u2014OCHF 2 , \u2014OCHCl 2 , \u2014OCHBr 2 , \u2014OCHI 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 1B , R 1C , R 2B , R 2C , R 3B , R 3C , R 4B , R 4C , R 5B  and R 5C  substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; and \n X 1.1 , X 2.1 , X 3.1 , X 4.1  and X 5.1  are independently \u2014Cl, \u2014Br, \u2014I or \u2014F.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 94.0
- Lexical Diversity: 1.1
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15662861', '15700040', '16016290', '15123232', '15648245']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8429551962629162
- 35 USC 102 Novelty (BERT): 0.678213457384059
- Combined Prediction Score: 0.8264810223750305
- Mean Citation Score: 712.557042
- Max Citation Score: 823.76996
- Similarity Product: 642.3685952252722

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test