PATENT CLAIM ANALYSIS

Application Number: 16078568
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["530", "399000"]

Abstract:
The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.

Claim (Index 3):
The production method according to  claim 1 , characterized in that said step of adjusting the culture supernatant to weakly acidic is a step of adjusting pH to 4.0-6.0.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 96.0
- Lexical Diversity: 2.15517
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13175110', '12226448', '11189230', '10000096', '10926088']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6783939169126083
- 35 USC 102 Novelty (BERT): 0.5208150657125983
- Combined Prediction Score: 0.6626360317926073
- Mean Citation Score: 219.333756
- Max Citation Score: 237.10527
- Similarity Product: 115.1267150013238

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test