PATENT CLAIM ANALYSIS

Application Number: 15939503
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["435", "006110"]

Abstract:
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.

Claim (Index 1):
A method of treating or reducing the risk of a neurodegenerative disease in a human, the method comprising administering to said human an anti-PD-1 antibody or antibody fragment that specifically binds to a human PD-1 that is expressed by a PD-1 nucleotide sequence comprising a variation selected from the group consisting of:\n rs7568402; rs28699177; rs28542728; rs118117097; rs28570544; rs118027315; rs191919871; rs6707556; rs142909968; rs36084323; rs10204225; rs11568821; rs2227981; and rs2227982; wherein the antibody or antibody fragment that specifically binds to human PD-1 comprises: (j) a human gamma-1 heavy chain constant region that comprises an amino acid selected from the group consisting of:\n an Asp corresponding to position 204 of SEQ ID NO: 42 and a Leu corresponding to position 206 of SEQ ID NO: 42; or \n (ii) a human gamma-4 heavy chain constant region that comprises an amino acid selected from the group consisting of:\n a Leu corresponding to position 189 of SEQ ID NO: 73 and a Arg corresponding to position 289 of SEQ ID NO: 73; and \n wherein said human comprises: (iii) an IGHG1*01 human heavy chain constant region gene segment, or the human expresses antibodies comprising human gamma-1 heavy chain constant regions comprising said selected amino acid of clause (i), when the antibody or fragment is according to clause (i); or (iv) an IGHG4*01 human heavy chain constant region gene segment, or the human expresses antibodies comprising human gamma-4 heavy chain constant regions comprising said selected amino acid of clause (ii), when the antibody or fragment is according to clause (ii); and wherein said human comprises: (v) a PD-1 nucleotide sequence comprising said selected variation.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 90.0
- Lexical Diversity: 1.05263
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14536049', '14659910', '14868952', '14731727', '14472685']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7469502101474457
- 35 USC 102 Novelty (BERT): 0.6360937081513667
- Combined Prediction Score: 0.7358645599478377
- Mean Citation Score: 742.2168399999997
- Max Citation Score: 752.7656
- Similarity Product: 575.1935008369923

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test