PATENT CLAIM ANALYSIS

Application Number: 16008856
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["435", "007920"]

Abstract:
The present invention provides a method of detecting a  Mycobacterium -specific metabolite in the form of mycothiol in a biological sample in vitro, including the steps of preparing a reaction mixture by combining the biological sample with an enzymatic solution containing a reaction buffer, nicotinamide adenine dinucleotide (NAD) and a formaldehyde dependent mycothiol dehydrogenase (FD-MDH); allowing reduction of NAD in the reaction mixture by interaction of FD-MDH with a predetermined  Mycobacterium -specific metabolite in the form of mycothiol if present in the biological sample; and detecting reduced NAD within the sample, indicative of the presence of mycothiol in the biological sample and thus of a  Mycobacterium  infection in the source of the biological sample.

Claim (Index 5):
The method of  claim 4 , wherein the enzymatic solution is selected from the group consisting of sodium chloride, formaldehyde, tris(hydroxymethyl)aminomethane, dithiothreitol, and combinations thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 2.17544
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14048905', '13094809', '15504633', '12810217', '13119938']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5874148228151723
- 35 USC 102 Novelty (BERT): 0.4865919152815484
- Combined Prediction Score: 0.5773325320618099
- Mean Citation Score: 198.601996
- Max Citation Score: 211.49985
- Similarity Product: 161.75266741791663

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test