PATENT CLAIM ANALYSIS

Application Number: 16125401
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["546", "153000"]

Abstract:
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine (AL3818). A stable crystalline form of Al3818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I.

Claim (Index 1):
A crystalline form of a compound, 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-quino-lin-7-yloxy)methyl)cyclopropanamine, wherein the crystalline form exhibits a XRPD having the following characteristic peaks: NO. Angle 1 7.640 2 8.642 3 9.361 4 10.091 5 13.740 6 14.479 7 15.186 8 15.766 9 17.206 10 18.569 11 19.271 12 20.041 13 22.211 14 22.814 15 23.398 16 24.455 17 25.524 18 26.703 19 27.337 20 28.061 21 28.801 22 29.845 23 31.331 24 31.621 25 32.840 26 33.714 27 38.348

Metadata:
- Claim Count in Document: 50.0
- Percentile: 97.0
- Lexical Diversity: 1.52174
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15659510', '15143630', '14760549', '12036244', '15460633']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7833167539240495
- 35 USC 102 Novelty (BERT): 0.5932970744795014
- Combined Prediction Score: 0.7643147859795948
- Mean Citation Score: 366.803362
- Max Citation Score: 538.4721
- Similarity Product: 418.03351866091486

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test