PATENT CLAIM ANALYSIS

Application Number: 16085536
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-07
Patent Classification: ["514", "259300"]

Abstract:
Provided are isotopologues of isoquinolinone and quinazolinone compounds of formula (AB′) that modulate PI3 kinase activity, processes for the preparation of the compounds, pharmaceutical compositions comprising the compounds, and methods of treatment of diseases and disorders using the compounds or pharmaceutical compositions.

Claim (Index 1):
A compound of Formula (AB\u2032): or a pharmaceutically acceptable form thereof, wherein R is C 1 -C 3  alkyl optionally substituted with one or more deuterium or halogen; X is CY 5d  or N; Y 1  is hydrogen or deuterium; Y 2 , Y 3 , and Y 4  are each independently hydrogen or deuterium; Y 5a , Y 5b , Y 5c , and Y 5d  are each independently hydrogen or deuterium; Y 6a , Y 6b , Y 7a , Y 7b , and Y 8  are each independently hydrogen, deuterium, halogen, or C 1 -C 3  alkyl, wherein each instance of the C 1 -C 3  alkyl is independently optionally substituted with one or more deuterium or halogen; Z is a 5- to 10-membered heteroaryl optionally substituted with one or more deuterium, halogen, or C 1 -C 3  alkyl, wherein each instance of the C 1 -C 3  alkyl is independently optionally substituted with one or more deuterium or halogen; and at least one of R, Y 1 , Y 2 , Y 3 , Y 4 , Y 5a , Y 5b , Y 5c , Y 5d , Y 6a , Y 6b , Y 7a , Y 7b , Y 8 , and Z is or comprises a deuterium; provided that, when Y 6a , Y 6b , Y 7a , Y 7b , and Y 8  are all deuterium, at least one of R, Y 1 , Y 2 , Y 3 , Y 4 , Y 5a , Y 5b , Y 5c , Y 5d , and Z is or comprises a deuterium.

Metadata:
- Claim Count in Document: 98.0
- Percentile: 97.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14874328', '15621815', '15755475', '14695699', '15794816']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6990950688908207
- 35 USC 102 Novelty (BERT): 0.5055896520991261
- Combined Prediction Score: 0.6797445272116514
- Mean Citation Score: 265.08322000000004
- Max Citation Score: 268.01678
- Similarity Product: 221.30360786413905

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test