PATENT CLAIM ANALYSIS

Application Number: 15776548
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "260100"]

Abstract:
A compound or a salt thereof represented by Formula (I). An LSD1 inhibitor containing the compound or a salt thereof as an active ingredient. A pharmaceutical composition containing the compound or salt thereof. An antitumor agent containing the compound or a salt thereof as an active ingredient.

Claim (Index 6):
A compound selected from the group consisting of compounds (1)-(24)\n (1) 445-[(3-exo)-3-amino-8-azabicyclo[3.2.1]octane-8-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-methyl-propyl)phenyl]phenyl]-2-fluoro-benzonitrile, (2) 4-[5-[(3S)-3-aminopyrrolidine-1-carbonyl]-242-fluoro-4-(2-hydroxy-2-methyl-propyl)phenyl]phenyl]-2-fluoro-benzonitrile, (3) 4-[5-[(3-endo)-3-amino-8-azabicyclo[3.2.1]octane-8-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-methyl-propyl)phenyl]phenyl]-2-fluoro-benzonitrile, (4) (S)-5\u2019-(3-aminopyrrolidine-1-carbonyl)-3-fluoro-2\u2032-(6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-indol-5-yl)-[1,1\u2032-biphenyl]-4-carbonitrile, (5) 5\u2032-((3-endo)-3-amino-8-azabicyclo[3.2.1]octane-8-carbonyl)-2\u2032-(6,7-difluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile, (6) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2033,3-difluoro-4\u2033-(2-hydroxy-2-methylpropyl)41,1\u2032:2\u2032,1\u2033-terphenyl]-4-carbonitrile-isomer-B, (7) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(6,7-difluoro-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile-isomer-B, (8) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-3-fluoro-2\u2032-(6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-indazol-5-yl)41,1\u2032-biphenyl]-4-carbonitrile-isomer-B, (9) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(6,7-difluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile-isomer-B, (10) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(6,7-difluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile, (11) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(7-chloro-6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile-isomer-X, (12) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(7-chloro-6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile, (13) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(1-(2-ethyl-2-hydroxybutyl)-6,7-difluoro-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile-isomer-X, (14) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(1-(2-ethyl-2-hydroxybutyl)-6,7-difluoro-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile, (15) (S)-5\u2032-(3-aminopyrrolidine-1-carbonyl)-3-fluoro-2\u2032-(5-fluoro-3-(2-hydroxy-2-methylpropyl)benzo[d]isoxazol-6-yl)41,1\u2032-biphenyl]-4-carbonitrile, (16) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(7-(difluoromethyl)-6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile-isomer-X, (17) 5-(5-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-4\u2032-cyano-3\u2032-fluoro-[1,1\u2032-biphenyl]-2-yl)-6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazole-7-carbonitrile-isomer-X, (18) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(7-(difluoromethyl)-6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile, (19) 5\u2032-((3-endo)-3-amino-8-azabicyclo[3.2.1]octane-8-carbonyl)-2\u2032-(7-chloro-6-fluoro-1-((1-hydroxycyclobutypmethyl)-1 H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile, (20) 5\u2032-((3-endo)-3-amino-8-azabicyclo[3.2.1]octane-8-carbonyl)-2\u2032-(7-(difluoromethyl)-6-fluoro-1-((1-hydroxycyclobutyl)methyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile, (21) 5-(5-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-4\u2032-cyano-3\u2032-fluoro-[1,1\u2032-biphenyl]-2-yl)-6-fluoro-1-((1-hydroxycyclobutyl)methyl)-1H-benzo[d][1,2,3]triazole-7-carbonitrile-isomer-X, (22) 5-(5-((1S,2S,4 R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-4\u2032-cyano-3\u2032-fluoro-[1,1\u2032-biphenyl]-2-yl)-6-fluoro-1-((1-hydroxycyclobutyl)methyl)-1H-benzo[d][1,2,3]triazole-7-carbonitrile, (23) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(7-bromo-6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile-isomer-X, (24) 5\u2032-((1S,2S,4R)-rel-2-amino-7-azabicyclo[2.2.1]heptane-7-carbonyl)-2\u2032-(7-bromo-6-fluoro-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d][1,2,3]triazol-5-yl)-3-fluoro-[1,1\u2032-biphenyl]-4-carbonitrile and salts thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 2.03846
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['10975524', '14107043', '15194980', '15403741', '15688089']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8029738875913641
- 35 USC 102 Novelty (BERT): 0.5243879279089219
- Combined Prediction Score: 0.7751152916231199
- Mean Citation Score: 331.224132
- Max Citation Score: 342.7141
- Similarity Product: 289.92093604279165

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test