PATENT CLAIM ANALYSIS

Application Number: 15745496
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "007100"]

Abstract:
Aspects of the disclosure relate to compositions of enzyme-binding polypeptides (EBPs) that modify the substrate specificity of an enzyme and a method for identifying an EBP that modifies substrate specificity of an enzyme binding at least one substrate, the method comprising: contacting the enzyme with a polypeptide library comprising a plurality of EBPs that bind different epitopes of the enzyme; identifying EBPs that bind to the enzyme to form an EBP-enzyme complex; assaying for the activity level and substrate specificity of the EBP-enzyme complex; and identifying EBPs that modify the substrate specificity of the enzyme by identifying EBPs that, when in an EBP-enzyme complex, have a different substrate specificity than un-complexed EBP; wherein the catalytic rate constant of the EBP-enzyme complex is ≥50% of the un-complexed enzyme for at least one substrate and/or wherein the EBP-enzyme complex retains binding to a substrate.

Claim (Index 31):
The method of  claim 30 , wherein the FN3 domain polypeptides further comprise one or more amino acid substitutions corresponding to amino acid positions 30, 41, 42, 43, 44, 45, 76, 77, 78, 79, 80, 81, 82, 83, 84, and/or 85 of SEQ ID NO:91.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 86.0
- Lexical Diversity: 2.44444
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13813409', '10006760', '13555379', '11848135', '10190162']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6268730236910879
- 35 USC 102 Novelty (BERT): 0.524694638500335
- Combined Prediction Score: 0.6166551851720126
- Mean Citation Score: 307.33611200000007
- Max Citation Score: 348.3478
- Similarity Product: 271.11462424502366

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test