PATENT CLAIM ANALYSIS

Application Number: 15984919
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["544", "070000"]

Abstract:
The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

Claim (Index 21):
The compound according to  claim 1 , wherein\n n means 1 or 2; R 1  means \u2014H or \u2014CH 3 ; R 2  means \u2014H or \u2014C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or monosubstituted with \u2014OH, \u2014OCH 3 , \u2014C(\u2550O)OCH 3 , or \u2014CN; R 3  means \u2014C 1 -C 4 -alkyl, optionally monosubstituted with \u2014OCH 3 ; -phenyl, -thienyl or -pyridinyl, in each case unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014CN, \u2014CH 3 , \u2014CH 2 CH 3 , \u2014CH 2 F, \u2014CHF 2 , \u2014CF 3 , \u2014OCF3, \u2014OH, \u2014OCH 3 , \u2014O\u2014CH 2 \u2014O\u2014CH 3 , \u2014C(\u2550O)NH 2 , C(\u2550O)NHCH 3 , \u2014C(\u2550O)N(CH 3 ) 2 , \u2014NH 2 , \u2014NHCH 3 , \u2014N(CH 3 ) 2 , \u2014NHC(\u2550O)CH 3 , \u2014CH 2 OH, SOCH 3  and SO 2 CH 3 ; or R 4  means \u2014H; \u2014C 1 -C 6 -alkyl, linear or branched, saturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2550O, \u2014OH, \u2014O\u2014C 1 -C 4 -alkyl, \u2014CO 2 H, \u2014C(\u2550O)O\u2014C 1 -C 4 -alkyl, \u2014C(\u2550O)NH 2 , \u2014C(\u2550O)NH\u2014C 1 -C 4 -alkyl, \u2014C(\u2550O)N(C 1 -C 4 -alkyl) 2 , \u2014C(\u2550O)NH\u2014C 1 -C 4 -alkyl-CN, \u2014C(\u2550O)NCH 3 \u2014C 1 -C 4 -alkyl-CN, \u2014C(\u2550O)NH-cyclopropyl-CN, \u2014C(\u2550O)NCH 3 -cyclopropyl-CN, \u2014C(\u2550O)NH\u2014C 1 -C 4 -alkyl-OH, \u2014C(\u2550O)NCH 3 \u2014C 1 -C 4 -alkyl-OH, \u2014C(\u2550O)NH\u2014C 1 -C 4 -alkyl-OCH 3 , \u2014C(\u2550O)NCH 3 \u2014C 1 -C 4 -alkyl-OCH 3 , \u2014C(\u2550O)NRR\u2032 wherein R and R\u2032 together with the nitrogen atom to which they are attached form a ring and mean \u2014(CH 2 ) 2-4 \u2014; 3-6-membered cycloalkyl, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014OH, and \u2014O\u2014C 1 -C 4 -alkyl, wherein said 3-6-membered cycloalkyl is connected through \u2014C 1 -C 6 -alkylene; 3-6-membered heterocycloalkyl, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014CO 2 H, \u2014C(\u2550O)O\u2014C 1 -C 4 -alkyl, \u2014OH, and \u2014O\u2014C 1 -C 4 -alkyl, wherein said 3-6-membered heterocycloalkyl is connected through \u2014C 1 -C 6 -alkylene; 6-14-membered aryl, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014CO 2 H, \u2014C(\u2550O)O\u2014C 1 -C 4 -alkyl, \u2014OH, and \u2014O\u2014C 1 -C 4 -alkyl; wherein said 6-14-membered aryl is connected through \u2014C 1 -C 6 -alkylene- or \u2014S(\u2550O) 2 \u2014; 5-14-membered heteroaryl, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F, \u2014Cl, \u2014Br, \u2014I, \u2014CN, \u2014CO 2 H, \u2014C(\u2550O)O\u2014C 1 -C 4 -alkyl, \u2014OH, and \u2014O\u2014C 1 -C 4 -alkyl; wherein said 5-14-membered heteroaryl is connected through \u2014C 1 -C 6 -alkylene- or \u2014S(\u2550O) 2 \u2014; R 5  means -phenyl, -pyrazinyl, -pyridazinyl, -pyridinyl, -pyrimidinyl, -thienyl, -imidazolyl, triazolyl, or \u22121,3-benzodioxolyl, in each case unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of \u2014F; \u2014Cl; \u2014Br; \u2014I; \u2014CN; \u2014OH; \u2014C 1 -C 4 -alkyl; \u2014CF 3 ; \u2014C 1 -C 4 -alkyl-OH; \u2014C 1 -C 4 -alkyl-C(\u2550O)NH 2 ; \u22123-12-membered cycloalkyl, saturated or unsaturated, unsubstituted, mono- or polysubstituted; preferably -cyclopropyl, saturated, unsubstituted; \u22123-12-membered heterocycloalkyl, saturated or unsaturated, unsubstituted, mono- or polysubstituted; \u2014O\u2014CH 2 \u2014O\u2014; \u2014O\u2014C 1 -C 4 -alkyl; \u2014O\u2014(CH 2 CH 2 \u2014O) 1-30 \u2014H; \u2014O\u2014(CH 2 CH 2 \u2014O) 1-30 \u2014CH 3 ; \u2014C(\u2550O)OH; \u2014C(\u2550O)OC 1 -C 4 -alkyl; \u2014C(\u2550O)NH 2 ; \u2014C(\u2550O)NHC 1 -C 4 -alkyl; \u2014C(\u2550O)N(C 1 -C 4 -alkyl) 2 ; \u2014SC 1 -C 4 -alkyl; \u2014S(\u2550O)C 1 -C 4 -alkyl and \u2014S(\u2550O) 2 C 1 -C 4 -alkyl; and R 7 , R 8 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , and R 20  mean \u2014H.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.17857
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12699451', '11994001', '12700857', '12604691', '15125615']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8553012285347038
- 35 USC 102 Novelty (BERT): 0.5351624393525953
- Combined Prediction Score: 0.823287349616493
- Mean Citation Score: 379.6739940000001
- Max Citation Score: 389.5721
- Similarity Product: 329.59404796204564

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test