PATENT CLAIM ANALYSIS

Application Number: 15741816
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "186100"]

Abstract:
The present application discloses stability-indicating potency assays for influenza vaccines.

Claim (Index 2):
A method comprising the steps of:\n a) providing a sample comprising immunogenic HA, inactive HA, or combination thereof; b) subjecting the sample to biological proteolysis by one or more proteases, wherein the inactive HA is digested and the immunogenic HA remains undigested; c) subjecting the mixture of undigested immunogenic HA and digested inactive HA to analytical proteolysis using one or more proteases, wherein the analytical proteolysis cannot cleave the immunogenic HA at one or more cleavage site(s) which can be cleaved in the inactive HA during biological proteolysis, so as to provide fragments of digested immunogenic HA that comprise immunogenic HA-derived peptide(s) that is/are distinguishable from the inactive HA-derived peptides; and, d) carrying out liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS) in the presence of at least one labeled reference HA peptide, to quantify the amount of immunogenic HA in the sample.

Metadata:
- Claim Count in Document: 122.0
- Percentile: 86.0
- Lexical Diversity: 1.0
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11119631', '12587136', '14619693', '14829158', '12704928']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7043661748998541
- 35 USC 102 Novelty (BERT): 0.5357808552736355
- Combined Prediction Score: 0.6875076429372322
- Mean Citation Score: 298.979428
- Max Citation Score: 352.89908
- Similarity Product: 233.7282756527209

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test