PATENT CLAIM ANALYSIS

Application Number: 15982284
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "182000"]

Abstract:
A process is provided for the making of estetrol starting from a 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is an C 1 -C 5  alkyl group, preferably a methyl group, or a C 7 -C 12  benzylic group, preferably a benzyl group. This process is particularly suitable to industry.

Claim (Index 5):
A method of hormone replacement therapy, treating vaginal dryness, contraception, enhancing libido, treating skin, promoting wound healing or of treating or preventing an autoimmune disease, breast tumours and colorectal tumours, comprising administering to a subject in need thereof the pharmaceutical composition comprising a carrier and estra-1,3,5(10)-trien-3,15\u03b1,16\u03b1,17\u03b2-tetraol, wherein the estra-1,3,5(10)-trien-3,15\u03b1,16\u03b1,17\u03b2-tetraol is prepared in a process comprising:\n (a) converting estrone into 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is a protecting group; (b) reducing the 17-keto group of 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one to 3-A-oxy-estra-1,3,5(10),15-tetraen-17\u03b2-ol; (c) protecting the 17-OH group of 3-A-oxy-estra-1,3,5(10),15-tetraen-17\u03b2-ol to 3-A-oxy-17-Cp-oxy-estra-1,3,5(10),15-tetraene, wherein Cp is a protecting group; (d) oxidizing the carbon-carbon double bond of ring D of 3-A-oxy-17-Cp-oxy-estra-1,3,5(10),15-tetraene to protected estetrol; and (e) removing the protecting groups; wherein the protecting group A is selected from an C 1 -C 5  alkyl group or a C 7 -C 12  benzylic group and the protecting group Cp is selected from monofunctional aliphatic hydroxyl protecting groups.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.4359
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14578137', '15022177', '14349940', '14414386', '14348645']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7861670808428696
- 35 USC 102 Novelty (BERT): 0.5867138679267487
- Combined Prediction Score: 0.7662217595512576
- Mean Citation Score: 385.3668799999999
- Max Citation Score: 575.4507
- Similarity Product: 397.88176949002144

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test