PATENT CLAIM ANALYSIS

Application Number: 15950608
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-03
Patent Classification: ["514", "573000"]

Abstract:
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

Claim (Index 58):
A method for treating a cancer, comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt, hydrate, solvate or a mixture thereof, wherein:\n (a) each occurrence of m is independently an integer ranging from 0 to 5; \n (b) each occurrence of n is independently an integer ranging from 3 to 7; \n (c) X is (CH 2 ) z  or Ph, wherein z is an integer from 0 to 4; \n (d) R 1  and R 2  and the carbon to which they are both attached are taken together to form a (C 3 -C 7 )cycloalkyl group; \n (e) each occurrence of R 11  and R 12  and the carbon to which they are both attached are taken together to form a (C 3 -C 7 )cycloalkyl group; and \n (f) each occurrence of Y 1  and Y 2  is independently COOH, COOR 3 , SO 3 H, wherein:\n (i) R 3  is (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (C 1 -C 6 )alkoxy, or phenyl groups, and \n (ii) each occurrence of R 4  is independently H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, C 1 -C 6  alkoxy, or phenyl groups.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 91.0
- Lexical Diversity: 1.76344
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13270297', '13414855', '13650852', '15274436', '11426380']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7523979995863759
- 35 USC 102 Novelty (BERT): 0.5231079047439422
- Combined Prediction Score: 0.7294689901021325
- Mean Citation Score: 329.27674599999995
- Max Citation Score: 332.31796
- Similarity Product: 300.98858604314563

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test