PATENT CLAIM ANALYSIS

Application Number: 16083879
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["549", "023000"]

Abstract:
Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.

Claim (Index 2):
The compound represented by formula I as defined in  claim 1 , wherein,\n when each of R 2 , R 3 , R 4  and R 5  is independently halogen, the \u201chalogen\u201d is fluorine, chlorine, bromine or iodine; when each of R 2 , R 3 , R 4  and R 5  is independently \u201cC 1 -C 6  alkyl\u201d, the \u201cC 1 -C 6  alkyl\u201d is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, pentyl or hexyl; when each of R 2 , R 3 , R 4  and R 5  is independently \u201cC 2 -C 6  alkenyl\u201d, the \u201cC 2 -C 6  alkenyl\u201d is vinyl or propenyl; when each of R 2 , R 3 , R 4  and R 5  is independently \u201cC 1 -C 6  alkyl substituted with halogen\u201d, the \u201cC 1 -C 6  alkyl substituted with halogen\u201d is trifluoromethyl; when each of R 2 , R 3 , R 4  and R 5  is independently \u201cC 1 -C 6  alkoxy\u201d, the \u201cC 1 -C 6  alkoxy\u201d is methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, tert-butoxy, pentoxy or hexoxy; when each of R 2 , R 3 , R 4  and R 5  is independently \u201cC 1 -C 6  acyl\u201d, the \u201cC 1 -C 6  acyl\u201d is acetyl or formyl; when each of R 2 , R 3 , R 4  and R 5  is independently \u201cC 6 -C 10  aryl\u201d, the \u201cC 6 -C 10  aryl\u201d is phenyl; when each of R 2 , R 3 , R 4  and R 5  is independently \u201cC 3 -C 6  heteroaryl having 1 to 2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen\u201d, the \u201cC 3 -C 6  heteroaryl having 1 to 2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen\u201d is pyridinyl or pyrimidinyl; when R 1  is \u201chalogen\u201d, the \u201chalogen\u201d is fluorine, chlorine, bromine or iodine; when R 1  is \u201cC 1 -C 6  alkyl\u201d, the \u201cC 1 -C 6  alkyl\u201d is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, pentyl or hexyl; when R 1  is \u201cC 1 -C 6  alkyl substituted with halogen\u201d, the \u201cC 1 -C 6  alkyl substituted with halogen\u201d is trifluoromethyl; when R 1  is \u201cC 1 -C 6  alkoxy\u201d, the \u201cC 1 -C 6  alkoxy\u201d is methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, tert-butoxy, pentoxy or hexoxy; when each of R 6 , R 7  and R 8  is independently \u201cC 1 -C 6  alkyl\u201d, the \u201cC 1 -C 6  alkyl\u201d is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, pentyl or hexyl; when each of R 9a , R 9b , R 9c  and R 9d  is independently \u201chalogen\u201d, the \u201chalogen\u201d is fluorine, chlorine, bromine or iodine; when each of R 9a , R 9b , R 9c  and R 9d  is independently \u201cC 1 -C 6  alkyl\u201d, the \u201cC 1 -C 6  alkyl\u201d is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, pentyl or hexyl; when each of R 9a , R 9b , R 9c  and R 9d  is independently \u201cC 1 -C 6  alkyl substituted with halogen\u201d, the \u201cC 1 -C 6  alkyl substituted with halogen\u201d is trifluoromethyl; when each of R 9a , R 9b , R 9c  and R 9d  is independently \u201cC 1 -C 6  alkoxy\u201d, the \u201cC 1 -C 6  alkoxy\u201d is methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, tert-butoxy, pentoxy or hexoxy; when each of R 10 , R 11 , R 12 , R 13  and R 14  is independently \u201cC 1 -C 6  alkyl\u201d, the \u201cC 1 -C 6  alkyl\u201d is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, pentyl or hexyl; when each of R 15  and R 16  is independently \u201cC 1 -C 6  alkyl\u201d, the \u201cC 1 -C 6  alkyl\u201d is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, pentyl or hexyl; when each of R 15  and R 16  is independently \u201cC 2 -C 6  alkenyl\u201d, the \u201cC 2 -C 6  alkenyl\u201d is vinyl or propenyl; when each of R 15  and R 16  is independently \u201cC 1 -C 6  acyl\u201d, the \u201cC 1 -C 6  acyl\u201d is formyl or acetyl.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 1.25926
- Patent Class: 549.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15025618', '12780132', '15999075', '13302409', '12524545']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8000657733014053
- 35 USC 102 Novelty (BERT): 0.5142165050839441
- Combined Prediction Score: 0.7714808464796592
- Mean Citation Score: 315.0832680000001
- Max Citation Score: 317.32526
- Similarity Product: 249.63991770876527

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test