PATENT CLAIM ANALYSIS

Application Number: 16067110
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["435", "007100"]

Abstract:
The invention relates to methods of identifying compounds that modulate mTORC1 activity in a cell by modulating the activity of CASTOR1, as well as to the use of such identified compounds in the modulation of mTORC1 and the treatment of diseases and conditions characterized by aberrant mTORC1 activity.

Claim (Index 41):
The method of  claim 29  or  39 , wherein the disease, condition or disorder is selected from a metabolic disease (e.g., type 2 diabetes, obesity, non-alcoholic steatohepatitis (NASH), and hyperlipidemia), a neurodegenerative disease (e.g., Alzheimer's disease, Parkinson's Disease, Huntington's Disease, and amyotrophic lateral sclerosis), an autoimmune disease (e.g., psoriasis, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, gout, allergic rhinitis, Crohn's Disease, and ulcerative colitis), rare and mitochondrial disease (e.g., Leigh's Syndrome, Friedreich's Ataxia Cardiomyopathy, Leber's Hereditary Optic Neuropathy, lymphangioleiomyomatosis, tuberous sclerosis, Pompe Disease (Glycogen storage disease II), and lysosomal storage diseases), cardiovascular disease (e.g., cardiomyopathy, heart failure, ischemic heart disease (atherosclerotic disease), ischemic stroke, and pulmonary arterial hypertension), renal disease (e.g., diabetic nephropathy, polycystic kidney disease, and acute kidney injury), neuropsychiatric disease (e.g., epilepsy, autism spectrum disorder, and depressive disorder), oncological disease (e.g., renal cell carcinoma, solid tumors, hematological cancers, cancer-related cachexia (by increasing appetite)), other needs for increasing appetite, and improving immune response to vaccines and other medically important uses in cases of a suppressed immune system such as age-related immunosenescence and cancer immunotherapy.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 94.0
- Lexical Diversity: 1.51515
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15511007', '15308605', '13584607', '14223188', '12900289']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.655495495605807
- 35 USC 102 Novelty (BERT): 0.5537727280548626
- Combined Prediction Score: 0.6453232188507125
- Mean Citation Score: 355.14326199999994
- Max Citation Score: 526.1424599999998
- Similarity Product: 277.7739266355371

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test