PATENT CLAIM ANALYSIS

Application Number: 15893259
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-08
Patent Classification: ["250", "282000"]

Abstract:
The invention pertains to materials and methods for identifying and/or isolating isomers, particularly, of biomolecules, such as polypeptides and proteins. The methods of identifying and/or isolating isomers of a molecule according to the invention comprise subjecting a sample to ionization prior to IMS followed by MS. In some embodiments, the sample is subjected to metallization during the ionization step.

Claim (Index 1):
A method of identifying two or more isomers of a molecule in a sample, the method comprising subjecting the sample to a step of ionization comprising a step of metalation comprising the formation of an ionic complex between the molecule and one or more transition metal(s) having one or more oxidation state(s), following the step of ionization by a step of ion mobility spectrometry (IMS), the step of IMS comprising a step of tandem non-linear IMS and a step of linear high resolution IMS, and following the step of IMS by a step of mass spectrometry (MS), the step of IMS followed by the step of MS separating the two or more isomers of the molecule based on unique collision cross sections of the ionic complexes formed between the two or more isomers of the molecule and the one or more transition metal(s).

Metadata:
- Claim Count in Document: 51.0
- Percentile: 88.0
- Lexical Diversity: 1.57143
- Patent Class: 250.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13881684', '14477726', '15330635', '15519126', '10175486']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6862634054452674
- 35 USC 102 Novelty (BERT): 0.4840736729459239
- Combined Prediction Score: 0.666044432195333
- Mean Citation Score: 185.939378
- Max Citation Score: 205.25795
- Similarity Product: 147.1409441262096

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test