PATENT CLAIM ANALYSIS

Application Number: 15957739
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "487000"]

Abstract:
Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

Claim (Index 6):
The compound of  claim 1 , wherein the compound is represented by a compound of formula (VIIIe): wherein: each of X 4  and X 5  are independently N, CH or CZ 3 ; each Z 1  is independently halo, \u2014OR a , \u2014CN, or \u2014C 1-6  alkyl; each w is independently 0, 1 or 2; each Z 3  is independently halo, \u2014OR a , \u2014N 3 , \u2014NO 2 , \u2014CN, \u2014NR 1 R 2 , \u2014SO 2 R a , \u2014SO 2 NR a R b , \u2014NR a SO 2 R a , \u2014NR a C(O)R a , \u2014C(O)R a , \u2014C(O)OR a , \u2014C(O)NR a R b , \u2014NR a C(O)OR a , \u2014NR a C(O)NR 1 R 2 , \u2014OC(O)NR a R b , \u2014NR a SO 2 NR a R b , \u2014C(O)NR a SO 2 NR a R b , \u2014C 1-6  alkyl, \u2014C 2-6  alkenyl, \u2014C 2-6  alkynyl, \u2014O\u2014C 1-6  alkyl, \u2014C 3-8  cycloalkyl, \u2014C 1-6  alkylC 3-8  cycloalkyl, aryl, heteroaryl, heterocyclyl, and R N ; and\n wherein the alkyl, alkenyl, alkynyl, C 3-8  cycloalkyl, aryl, heteroaryl, or heterocyclyl group is optionally substituted with 1 to 4 groups independently selected from oxo, \u2014NO 2 , \u2014N 3 , \u2014OR a , halo, cyano, \u2014NR a R b , \u2014C(O)R a , \u2014C(O)OR a , \u2014O\u2014C 1-6 -cyanoalkyl, \u2014C(O)NR a R b , NR a C(O)R a , \u2014NR a C(O)OR a , \u2014SO 2 R a , \u2014NR a SO 2 R b , \u2014SO 2 NR a R b , \u2014NR a SO 2 NR a R b , \u2014C(O)NR a SO 2 NR a R b  and \u2014C 3-8  cycloalkyl; and further wherein the heteroaryl or heterocyclic group may be oxidized on a nitrogen atom to form an N-oxide or oxidized on a sulfur atom to form a sulfoxide or sulfone; \n R N  is independently \u2014C 1-6  alkylNR 1 R 2 , \u2014O\u2014C 1-6  alkylNR 1 R 2 , \u2014C 1-6  alkylOC 1-6  alkylNR 1 R 2 , \u2014NR a \u2014C 1-6  alkylNR 1 R 2 , \u2014C 1-6  alkylC(O)NR 1 R 2 , \u2014O\u2014C 1-6  alkylC(O)NR 1 R 2 , \u2014O\u2014C 1-6  alkylC(O)OR 1 , \u2014S\u2014C 1-6  alkylNR 1 R 2 , \u2014C 1-6  alkylOR a , \n wherein: L 1  is independently a bond, O, NR a , S, SO, or SO 2 ; V is independently selected from a bond, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl;\n wherein each alkyl, alkenyl, or alkynyl is optionally independently substituted with OR a , halo, cyano, \u2014NR a R b  or \u2014C 3-8  cycloalkyl; \n L 2  is independently a bond, O, NR a , S, SO, or SO 2 ; ring A is independently cycloalkyl, aryl, heteroaryl, or heterocyclyl;\n wherein each cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 4 groups independently selected from oxo, \u2014NO 2 , \u2014N 3 , \u2014OR a , halo, cyano, \u2014C 1-6  alkyl, \u2014C 1-6  haloalkyl, \u2014C 2-6 alkenyl, \u2014C 2-6  alkynyl, \u2014O\u2014C 1-6  haloalkyl, NR a R b , \u2014C(O)R a , \u2014C(O)OR a , \u2014O\u2014C 1-6  alkylCN, \u2014C(O)NR a R b , \u2014NR a C(O)R a , \u2014NR a C(O)OR a , \u2014NR a C(O)OR a , \u2014C(O)N(R a )OR b , \u2014SO 2 R a , \u2014SO 2 NR a R b , \u2014NR a SO 2 R b , \u2014NR a SO 2 NR a R b , \u2014C(O)NR a SO 2 NR a R b , C 3-8 cycloalkyl, and C 1-6 alkylC 3-8  cycloalkyl; and \n \u2003wherein the alkyl, alkenyl, or alkynyl group is optionally independently substituted with \u2014OR a , halo, cyano, \u2014NR a R b  or \u2014C 3-8  cycloalkyl; \n each t is independently 0, 1 or 2; each R 1  is independently selected from H, \u2014C 1-8  alkyl, \u2014C 2-6  alkenyl, \u2014C 2-6  alkynyl, \u2014C 3-6  cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014C 1-6  alkylaryl, \u2014C 1-6  alkylheteroaryl, \u2014C 1-6  alkylheterocyclyl, \u2014C 1-6  alkylC(O)OR a , \u2014C 2-6  alkenylC(O)OR a , \u2014SO 2 R a , \u2014SO 2 NR a R b , \u2014C(O)NR a SO 2 R a , and C 1-6  alkylC 3-8 cycloalkyl;\n wherein each alkyl, alkenyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 4 groups independently selected from \u2014OR a , \u2014CN, halo, C 1-6 alkyl, \u2014C 1-6  alkylOR a , \u2014C 1-6  cyanoalkyl, \u2014C 1-6  haloalkyl, C 3-8  cycloalkyl, \u2014C 1-3  alkylC 3-8 cycloalkyl, \u2014C(O)R a , \u2014C 1-6  alkylC(O)R a , \u2014C(O)OR a , \u2014C 1-6  alkylC(O)OR a , \u2014NR a R b , \u2014OC(O)NR a R b , \u2014NR a C(O)OR b , \u2014C 1-6  alkylNR a R b , \u2014C(O)NR a R b , \u2014C 1-6  alkylC(O)NR a R b , \u2014SO 2 R a , \u2014C 1-6  alkylSO 2 R a , \u2014SO 2 NR a R b , \u2014C 1-6  alkylSO 2 NR a R b , \u2014C(O)NR a SO 2 R b , \u2014C 1-6  alkylC(O)NR a SO 2 R b , \u2014NR a C(O)R b , and \u2014C 1-6 alkylNR a C(O)R b ; \n each R 2  is independently selected from H, \u2014C 1-6  alkyl, \u2014C 2-6  alkenyl, \u2014C 2-6  alkynyl, \u2014C 3-6  cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014C 1-6  alkylaryl, \u2014C 1-6  alkylheteroaryl, \u2014C 1-6  alkylheterocyclyl, \u2014C 2-6  alkyl-OR a , \u2014C 1-6  alkylC(O)OR a , and \u2014C 2-6  alkenylC(O)OR a ;\n wherein each alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 4 groups independently selected from \u2014OR a , \u2014CN, halo, C 1-6 alkyl, \u2014C 1-6  alkylOR a , \u2014C 1-6  cyanoalkyl, \u2014C 1-6  haloalkyl, \u2014C 3-8  cycloalkyl, \u2014C 1-3  alkylC 3-8 cycloalkyl, \u2014C(O)R a , \u2014C 1-6  alkylC(O)R a , \u2014C(O)OR a , \u2014C 1-6  alkylC(O)OR a , \u2014NR a R b , \u2014C 1-6  alkylNR a R b , \u2014C(O)NR a R b , C 1-6  alkylC(O)NR a R b , \u2014SO 2 R a , \u2014C 1-6  alkylSO 2 R a , \u2014SO 2 NR a R b , \u2014C 1-6  alkylSO 2 NR a R b , \u2014C(O)NR a SO 2 R b  and \u2014NR a C(O)R b ; \n or R 1  and R 2  combine to form a heterocyclyl group optionally containing 1, 2, or 3 additional heteroatoms independently selected from oxygen, sulfur and nitrogen, and optionally substituted with 1 to 3 groups independently selected from oxo, \u2014C 1-6  alkyl, \u2014C 3-8  cycloalkyl, \u2014C 2-6  alkenyl, \u2014C 2-6  alkynyl, \u2014OR a , \u2014C(O)OR a , \u2014C 1-6  cyanoalkyl, \u2014C 1-6  alkylOR a , \u2014C 1-6  haloalkyl, \u2014C 1-3  alkylC 3-8 cycloalkyl, \u2014C(O)R a , C 1-6  alkylC(O)R a , \u2014C 1-6  alkylC(O)OR a , \u2014NR a R b , \u2014C 1-6 alkylNR a R b , \u2014C(O)NR a R b , \u2014C 1-6  alkylC(O)NR a R b , \u2014SO 2 R a , \u2014C 1-6  alkylSO 2 R a , \u2014SO 2 NR a R b , and C 1-6  alkylSO 2 NR a R b ; each R 3  is independently H, \u2014C 1-6  alkyl, \u2014C 2-6  alkenyl, \u2014C 3-6  cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014C 1-6  alkylaryl, \u2014C 1-6  alkylheteroaryl, \u2014C 1-6  alkylheterocyclyl, \u2014C 2-6  alkyl-OR a , \u2014C 1-6  alkylC(O)OR a , or \u2014C 2-6  alkenylC(O)OR a ; each R a  is independently selected from H, \u2014C 1-6  alkyl, \u2014C 3-8  cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014C 1-3  alkylC 3-8 cycloalkyl, \u2014C 1-6  alkylaryl, \u2014C 1-6  alkylheteroaryl, and \u2014C 1-6 alkylheterocyclyl; each R b  is independently selected from H, \u2014C 1-6  alkyl, \u2014C 3-8  cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014C 1-3  alkylC 3-8 cycloalkyl, \u2014C 1-6  alkylaryl, \u2014C 1-6  alkylheteroaryl, and \u2014C 1-6  alkylheterocyclyl; or R a  and R b  may combine together to form a ring consisting of 3-8 ring atoms that are C, N, O, or S; wherein the ring is optionally substituted with 1 to 4 groups independently selected from \u2014OR f , \u2014CN, halo, \u2014C 1-6  alkylOR f , \u2014C 1-6  cyanoalkyl, \u2014C 1-6  haloalkyl, \u2014C 3-8  cycloalkyl, \u2014C 1-3  alkylC 3-8 cycloalkyl, \u2014C(O)R f , \u2014C 1-6  alkylC(O)R f , \u2014C(O)OR f , \u2014C 1-6  alkylC(O)OR f , \u2014NR f R g , \u2014C 1-6  alkylNR f R g , \u2014C(O)NR f R g , \u2014C 1-6  alkylC(O)NR f R g , \u2014SO 2 R f , \u2014C 1-6  alkylSO 2 R f , \u2014SO 2 NR f R g , \u2014C 1-6  alkylSO 2 NR f R g , \u2014C(O)NR f SO 2 R g  and \u2014NR f C(O)R g ; each R c  is independently selected from H, OH, \u2014C 1-6  alkyl, \u2014C 3-8  cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014C 1-3  alkylC 3-8  cycloalkyl, \u2014C 1-6  alkylaryl, \u2014C 1-6  alkylheteroaryl, and \u2014C 1-6  alkylheterocyclyl; each R d  is independently selected from H, \u2014C 1-6  alkyl, \u2014C 3 -C 8 cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014C 1-3  alkylC 3-8 cycloalkyl, \u2014C 1-6  alkylaryl, \u2014C 1-6  alkylheteroaryl, and \u2014C 1-6  alkylheterocyclyl; each R f  is independently selected from H, \u2014C 1-6  alkyl, \u2014C 3-8  cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014C 1-3  alkylC 3-8  cycloalkyl, \u2014C 1-6  alkylaryl, \u2014C 1-6  alkylheteroaryl, and \u2014C 1-6  alkylheterocyclyl; and each R g  is independently selected from H, \u2014C 1-6  alkyl, \u2014C 3-8  cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014C 1-3  alkylC 3-8  cycloalkyl, \u2014C 1-6  alkylaryl, \u2014C 1-6  alkylheteroaryl, and \u2014C 1-6  alkylheterocyclyl; or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, solvate, or tautomer thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 91.0
- Lexical Diversity: 1.13793
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15825993', '13451370', '11008713', '11009841', '11010177']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8477176662785231
- 35 USC 102 Novelty (BERT): 0.5350116141779764
- Combined Prediction Score: 0.8164470610684684
- Mean Citation Score: 379.489292
- Max Citation Score: 383.7718
- Similarity Product: 255.66709647145268

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test