PATENT CLAIM ANALYSIS

Application Number: 15969864
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["544", "281000"]

Abstract:
The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.

Claim (Index 1):
A compound of formula: stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein:\n A is a 5- or 6-membered aromatic ring comprising 0-3 heteroatoms of N, S or O; \n each W is independently \u2014(CH 2 )\u2014or \u2014C(O)\u2014; \n L is a bond, CH 2 , NR 12 , O, or S; \n S/D is a single or double bond, and when a double bond, R 5  and R 7  are absent; \n m is 0, or an integer of 1-4; \n n is 0, or an integer of 1-4, wherein when n is more than 1, each R 2  may be different: \n p is 0, or an integer of 1-2, wherein when p is 0, m is non-zero, and when p is more than 1, each R 6  and each R 7  may be different; \n R 1 , R 4 , R 5 , R 6 , and R 7  are each independently H, halogen, heteroalkyl, alkyl, alkenyl, cycloalkyl, aryl, saturated or unsaturated heterocyclyl, heteroaryl, alkynyl, \u2014CN, \u2014NR 12 R 14 , \u2014OR 13 , \u2014COR 13 , \u2014CO 2 R 13 , \u2014CONR 13 R 14 , \u2014C(\u2550NR 13 )NR 14 R 15 , \u2014NR 13 CONR 14 R 15 , \u2014NR 13 CO 2 R 14 , \u2014SO 2 R 13 , \u2014NR 13 SO 2 NR 14 R 15 , or \u2014NR 13 SO 2 R 14 , wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heteroaryl, aryl, and saturated or unsaturated heterocyclyl are optionally substituted with at least one substituent R 16 , wherein (R 4  and R 5 ), or (R 4  and R 6 ), or (R 6  and R 7 ), or (R 6  and R 6  when p is 2), together with the atoms to which they are attached, can form a ring selected from cycloalkyl, saturated or unsaturated heterocycle, aryl, and heteroaryl rings optionally substituted with at least one substituent R 16 ; \n R 2  is halogen, alkyl, \u2014S-alkyl, \u2014CN, \u2014NR 13 R 14 , \u2014OR 13 , \u2014COR 13 , \u2014CO 2 R 13 , \u2014CONR 13 R 14 , \u2014C(\u2550NR 13 )NR 14 R 15 , \u2014NR 13 COR 14 , \u2014NR 13 CONR 14 R 15 , \u2014NR 13 CO 2 R 14 , \u2014SO 2 R 13 , \u2014NR 13 SO 2 NR 14 R 15 , or \u2014NR 13 SO 2 R 14 ; \n R 12  is H or lower alkyl; \n R 13 , R 14  and R 15  are each independently H, heteroalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, saturated or unsaturated heterocyclyl, aryl, or heteroaryl; wherein (R 13  and R 14 ), and/or (R 14  and R 15 ) together with the atom(s) to which they are attached, each can form a ring selected from cycloalkyl, saturated or unsaturated heterocycle, aryl, and heteroaryl rings optionally substituted with at least one substituent R 16 ; \n R 16  is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, oxo, \u2014CN, \u2014OR \u2014NR\u2032R\u2033, \u2014COR\u2032, \u2014CO 2 R\u2032, \u2014CONR\u2032R\u2033, \u2014C(\u2550NR\u2032)NR\u2033R\u2032\u2033, NR\u2032COR\u2033, \u2014NR\u2032CONR\u2032R\u2033, \u2014NR\u2032CO 2 R\u2033, \u2014SO 2 R\u2032, \u2014SO 2 aryl, \u2014NR\u2032SO 2 NR\u2033R\u2032\u2033, or \u2014NR\u2032SO 2 R\u2033, wherein R R\u2033, and R\u2032\u2033 are independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, wherein (R\u2032 and R\u2033), and/or (R\u2033 and R\u2032\u2033) together with the atoms to which they are attached, can form a ring selected from cycloalkyl, saturated or unsaturated heterocycle, aryl, and heteroaryl rings.

Metadata:
- Claim Count in Document: 46.0
- Percentile: 93.0
- Lexical Diversity: 1.39535
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14951494', '14723417', '15359871', '14349144', '11399484']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7950301478785967
- 35 USC 102 Novelty (BERT): 0.602010290149879
- Combined Prediction Score: 0.7757281621057249
- Mean Citation Score: 461.024532
- Max Citation Score: 532.4433
- Similarity Product: 480.86599083856345

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test