PATENT CLAIM ANALYSIS

Application Number: 16202210
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "230500"]

Abstract:
The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.

Claim (Index 45):
The method of any one of  claims 1 - 44 , wherein the HDAC11 inhibitor is a compound of Formula I: and pharmaceutically acceptable salts thereof wherein: Q is \u2014H, \u2014OC(O)NR 6 (C 1 -C 6 )alkylaryl, or \u2014OC(O)O(C 1 -C 6 )alkylaryl; Z is \u2014CH 2 \u2014, O, S or NR 6 ; X 1 , X 2 , X 3 , and X 4  are each independently, at each occurrence, N or CR 1 ; Y 1 , Y 2 , Y 3 , and Y 4  are each independently N or CR 1 ; L is NR 6 , O, or \u2014(CR 1 R 2 ) p \u2014; R 1  and R 2  are independently, at each occurrence, \u2014H, \u2014R 3 , \u2014R 4 , \u2014C 1 -C 6 alkyl, \u2014C 2 -C 6 alkenyl, \u2014C 4 -C 8 cycloalkenyl, \u2014C 2 -C 6 alkynyl, \u2014C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, \u2014OH, \u2014OR 3 , halogen, \u2014NO 2 , \u2014CN, \u2014NHC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 NH 2 , \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014N(C 1 -C 6 alkyl)S(O) 2 R 5 , \u2014S(O) 2 (C 1 -C 6 alkyl), \u2014(C 1 -C 6 alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, or \u2014(CHR 5 ) p NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 3 , \u2014R 5 , \u2014SR 3 , \u2014OR 3 , \u2014NHR 3 , \u2014NR 3 R 4 , \u2014S(O) 2 N(R 3 ) 2 \u2014, \u2014S(O) 2 R 5 , \u2014C(O)R 5 , \u2014C(O)OR 5 , \u2014NR 3 S(O) 2 R 5 , \u2014S(O)R 5 , \u2014S(O)NR 3 R 4 , \u2014NR 3 S(O)R 5 , heterocycle, aryl, or heteroaryl; or R 1  and R 2  can combine with the carbon atom to which they are both attached to form a spirocycle, spiroheterocycle, or spirocycloalkenyl, each optionally substituted with one or more independent occurrences of R 3  and R 4 ; or two occurrences of R 1 , when on adjacent atoms, can combine to form a cycloalkyl, a heterocycle, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, or a cycloalkenyl, each optionally substituted with one or more independent occurrences of R 3  and R 4 ; R 3  and R 4  are independently, at each occurrence, \u2014H, \u2014C 1 -C 6 alkyl, \u2014C 2 -C 6 alkenyl, C 8 cycloalkenyl, \u2014C 2 -C 6 alkynyl, \u2014C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P, and O, \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 (C 1 -C 6 alkyl), \u2014(C 1 -C 6 alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, oxo, or \u2014(CHR 5 ) p N(C 1 -C 6 alkyl) 2 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 5 , \u2014O(C 1 -C 6 )alkyl, \u2014NH(C 1 -C 6 )alkyl, \u2014N(C 1 -C 6 alkly) 2 , \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 NHC 1 -C 6 alkyl, \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, \u2014S(O)R 5 , \u2014S(O)N(C 1 -C 6 alkyl) 2 , \u2014N(C 1 -C 6 alkyl)S(O)R 5 , heterocycle, aryl, or heteroaryl; R 5  is independently, at each occurrence, \u2014H, \u2014C 1 -C 6 alkyl, \u2014C 2 -C 6 alkenyl, C 8 cycloalkenyl, \u2014C 2 -C 6 alkynyl, \u2014C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P and O, \u2014OH, halogen, \u2014NO 2 , \u2014CN, \u2014NHC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 NH(C 1 -C 6 alkyl), \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 C 1 -C 6 alkyl, \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, \u2014S(O)(C 1 -C 6 alkyl), \u2014S(O)N(C 1 -C 6 alkyl) 2 , \u2014N(C 1 -C 6 alkyl)S(O)(C 1 -C 6 alkyl) or \u2014(CH 2 ) p N(C 1 -C 6 alkyl) 2 ; R 6  is independently, at each occurrence, \u2014H, \u2014C 1 -C 6 alkyl, \u2014C 2 -C 6 alkenyl, \u2014C 4 -C 8 cycloalkenyl, \u2014C 2 -C 6 alkynyl, \u2014C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 (C 1 -C 6 alkyl), \u2014(C 1 -C 6 alkyl)S(O) 2 R 5 , \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, or \u2014(CHR 5 ) p NR 3 R 4  wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from \u2014OH, halogen, \u2014NO 2 , oxo, \u2014CN, \u2014R 5 , \u2014O(C 1 -C 6 )alkyl, \u2014NH(C 1 -C 6 )alkyl, \u2014N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 N(C 1 -C 6 alkyl) 2 , \u2014S(O) 2 NHC 1 -C 6 alkyl, \u2014C(O)C 1 -C 6 alkyl, \u2014C(O)OC 1 -C 6 alkyl, \u2014N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, \u2014S(O)R 5 , \u2014S(O)N(C 1 -C 6 alkyl) 2 , \u2014N(C 1 -C 6 alkyl)S(O)R 5 , heterocycle, aryl, or heteroaryl; and\n p is 0, 1, 2, 3, 4, 5, or 6.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 98.0
- Lexical Diversity: 1.17241
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16202207', '15234412', '13683880', '11687565', '14763013']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7898078117741406
- 35 USC 102 Novelty (BERT): 0.6206798947112213
- Combined Prediction Score: 0.7728950200678487
- Mean Citation Score: 375.980184
- Max Citation Score: 624.77814
- Similarity Product: 482.1106205149627

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test