PATENT CLAIM ANALYSIS

Application Number: 16008856
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["435", "007920"]

Abstract:
The present invention provides a method of detecting a  Mycobacterium -specific metabolite in the form of mycothiol in a biological sample in vitro, including the steps of preparing a reaction mixture by combining the biological sample with an enzymatic solution containing a reaction buffer, nicotinamide adenine dinucleotide (NAD) and a formaldehyde dependent mycothiol dehydrogenase (FD-MDH); allowing reduction of NAD in the reaction mixture by interaction of FD-MDH with a predetermined  Mycobacterium -specific metabolite in the form of mycothiol if present in the biological sample; and detecting reduced NAD within the sample, indicative of the presence of mycothiol in the biological sample and thus of a  Mycobacterium  infection in the source of the biological sample.

Claim (Index 7):
The method of  claim 1 , wherein the NAD and/or reduced NAD concentration is measured by means of methods drawn from the group including colorimetric assays, enzymatic assays, chromatographic assays, mass spectroscopy and spectrophotometric assays, lateral flow device, naked eye detection, urine test strip and combinations thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 2.17544
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14048905', '13094809', '15504633', '12810217', '13119938']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5472659178466298
- 35 USC 102 Novelty (BERT): 0.5086581911270036
- Combined Prediction Score: 0.5434051451746672
- Mean Citation Score: 198.601996
- Max Citation Score: 211.49985
- Similarity Product: 129.13444515838623

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test