PATENT CLAIM ANALYSIS

Application Number: 16302158
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["514", "210180"]

Abstract:
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.

Claim (Index 1):
A compound of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or a solvate thereof, wherein:\n G is N or C; \n R 1  is phenyl, a 5- or 6-membered heteroaryl, or a 5- or 6-membered non-aromatic heterocyclyl; wherein the heteroaryl or non-aromatic heterocyclyl each independently comprises one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a , O, and S(O)Z, and the phenyl, heteroaryl or non-aromatic heterocyclyl is each independently substituted with 0, 1, 2, or 3 R 6 ; \n R 2  is, independently at each occurrence, selected from: halogen, OH, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, CN, NR b R c , NO 2 , CO 2 R d , and CONR b R c ; \n R 3  is \u2014(CH 2 ) Y \u2014CONR e R 4 ; \n R e  is hydrogen, C 1-4  alkyl, or C 3-6  carbocyclyl; \n R 4  is C 1-6  alkyl substituted with 0, 1, or 2 R 7 , \u2014(CH 2 ) Q \u2014(C 3-6  carbocyclyl substituted with 0, 1, or 2 R 7 ), or \u2014(CH 2 ) Q -(4- to 6-membered heterocyclyl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a , O, and S(O)Z, wherein the heterocycle is substituted with 0, 1, or 2 R 7 ; or alternatively, R e  and R 4 , taken together with the atoms to which they are attached, form a 5- or 6-membered azacyclyl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a , O, and S(O) Z , wherein the azacyclyl is substituted with 0, 1, or 2 R 5 ; \n R 6  is, independently at each occurrence, selected from: OH, halogen, C 1-6  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, NR f R g , OPh, OBn, Ph, and \u2014CONR h R i ; or alternatively, two R 6 , taken together with the atoms to which they are attached, form a 5- or 6-membered carbocyclyl, heteroaryl or non-aromatic heterocyclyl; wherein the heteroaryl or non-aromatic heterocyclyl each independently comprises one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a , O, and S(O) Z , and the carbocyclyl, heteroaryl or non-aromatic heterocyclyl is each independently substituted with 0, 1, 2, or 3 R 8 ; \n R 5 , R 7 , R 8 , and R 9  are, independently at each occurrence, selected from: OH, halogen, C 1-6  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, NR j R k , OPh, OBn, Ph, and a 5- or 6-membered heteroaryl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a  and O; \n R a , R b , R c , R d , R e , R j , and R k  are, independently at each occurrence, hydrogen, C 1-4  alkyl, or C 3-6  carbocyclyl; \n R f  and R g  are independently hydrogen, C 1-4  alkyl, C 3-6  carbocyclyl, CO 2 R m , or CONR n R p ; \n R h  and R i  are independently hydrogen, C 1-4  alkyl, C 3-6  carbocyclyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy; or alternatively, R h  and R i , taken together with the atoms to which they are attached, form a 5- or 6-membered azacyclyl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a , O, and S(O) Z , wherein the azacyclyl is substituted with 0, 1, or 2 R 9 ; \n R m , R n , and R p  are independently hydrogen, C 1-4  alkyl, C 3-6  carbocyclyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, aryl, arylalkyl, or a 5- or 6-membered heteroaryl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NR a  and O; \n X is 0, 1, 2, or 3; \n Y is 1, 2, or 3; \n Z is, independently at each occurrence, 0, 1, or 2; and \n Q is, independently at each occurrence, 0, 1, 2 or 3.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 98.0
- Lexical Diversity: 1.15152
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13936311', '13944921', '14427105', '14346745', '14390152']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7449050391086859
- 35 USC 102 Novelty (BERT): 0.516808285713558
- Combined Prediction Score: 0.7220953637691732
- Mean Citation Score: 302.8511640000001
- Max Citation Score: 311.87286
- Similarity Product: 272.38844624215363

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test