PATENT CLAIM ANALYSIS

Application Number: 15950863
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["506", "007000"]

Abstract:
Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients.

Claim (Index 17):
The method of  claim 2 , wherein:\n identifying the patient-specific somatic rearrangement includes making a mate-paired library from the tumor DNA of the patient, and identifying the breakpoint in the somatic rearrangement includes determining copy numbers of the mate pairs, wherein a different copy number between two members of a mate pair suggests that the tags span the breakpoint.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.32258
- Patent Class: 506.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14790833', '13339986', '14526344', '14466208', '11639712']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5736167651330893
- 35 USC 102 Novelty (BERT): 0.5827331305571506
- Combined Prediction Score: 0.5745284016754955
- Mean Citation Score: 285.68419
- Max Citation Score: 503.7
- Similarity Product: 392.0918209075929

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test