PATENT CLAIM ANALYSIS

Application Number: 16036340
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["435", "021000"]

Abstract:
Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification.

Claim (Index 1):
A method for determining the amount of total thiamine in a plasma or serum sample, comprising:\n (i) performing an organic solvent extraction of a plasma or serum sample, wherein the result of the extraction is an organic solvent phase and an aqueous phase; (ii) purifying thiamine from the aqueous phase of by liquid chromatography; (iii) ionizing the purified thiamine by electrospray ionization (ESI) in positive ion mode; (iv) determining the amount of thiamine by mass spectrometry, wherein the amount of total thiamine in the sample is determined.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 95.0
- Lexical Diversity: 1.16667
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11763380', '13208295', '11247409', '10726919', '12053325']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.555706006092496
- 35 USC 102 Novelty (BERT): 0.5047772198488439
- Combined Prediction Score: 0.5506131274681308
- Mean Citation Score: 240.512118
- Max Citation Score: 265.30316
- Similarity Product: 200.2923250121904

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test