PATENT CLAIM ANALYSIS

Application Number: 15745207
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["435", "069700"]

Abstract:
Disclosed in the present invention is a long-acting recombinant human follicle-stimulating hormone-Fc fusion protein (referred to as hFSH-Fc for short) and a preparation method thereof, wherein the hFSH-Fc protein is a dimerized fusion protein and the amino acid sequence thereof successively comprises an hFSHβ subunit, CTP, an hFSHα subunit, a flexible peptide linker and human IgG2 Fc variant from N-terminal to C-terminal. Also disclosed in the present invention is the use of the recombinant hFSH-Fc fusion protein composition in preparing drugs in the animal breeding field.

Claim (Index 2):
The recombinant hFSH-Fc fusion protein of  claim 1 , wherein the amino acid sequence of the hFSH\u03b2 subunit is an amino acid sequence shown in hFSH\u03b2 SEQ ID NO: 5 in which amino acid residues 1-18 in conventional hFSH\u03b2 subunit are deleted; wherein the amino acid sequence of the CTP is 28-34 amino acid residues from carboxy-terminal of HCG\u03b2 chain, preferably, the CTP is the sequence of 33 amino acid residues from carboxy-terminal of HCG\u03b2 chain, as shown in SEQ ID NO: 4; wherein the sequence of the amino acid residues of the is hFSH\u03b1 subunit is an amino acid sequence shown in hFSH\u03b1 SEQ ID NO: 3 in which amino acid residues 1-24 in conventional hFSH\u03b1 subunit are deleted; wherein the peptide linker comprises 2 to 20 amino acids, the peptide linker is present between the hFSH\u03b1 subunit and the human IgG2 Fc variant, and the peptide linker contains two or more amino acids selected from glycine, serine, alanine, and threonine, the preferred sequence is GlySerGlyGlyGlySerGlyGlyGlyGlySerGlyGlyGlyGlySer.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 1.59322
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['11045022', '10112321', '10119427', '14898698', '11490825']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6293712872921214
- 35 USC 102 Novelty (BERT): 0.5224943061954064
- Combined Prediction Score: 0.61868358918245
- Mean Citation Score: 329.981784
- Max Citation Score: 334.7434
- Similarity Product: 226.7219762346029

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test