PATENT CLAIM ANALYSIS

Application Number: 15756021
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "034000"]

Abstract:
The present invention relates to a preparation method for modified sodium alginate embolization microspheres and a method for carrying an anti-cancer drug doxorubicin by means of modified sodium alginate embolization microspheres. The preparation method includes the following steps: (1) sodium alginate is modified by using taurine, so that modified sodium alginate is synthesized; (2) with high-concentration aqueous modified sodium alginate solution as a water phase, mineral oil as an oil phase and polyaldehyde cellulose as a crosslinking agent, modified sodium alginate embolization microspheres are prepared by an inverse emulsification method. By modifying sodium alginate by means of taurine, on one hand, sulfonic acid groups are introduced into the embolization microspheres, so that the drug-carrying rate is increased; on the other hand, the viscosity of a sodium alginate solution is decreased, which is favorable for the preparation of the high-concentration sodium alginate solution, and thereby regular sodium alginate embolization microspheres can be obtained.

Claim (Index 6):
The method according to  claim 1 , wherein preparing polyaldehyde cellulose is carried out by the following steps:\n (1) adding 2.0 g of sodium carboxymethylcellulose powder into a flask of 250 ml, wherein a viscosity of 20 g/L of sodium carboxymethylcellulose thereof in water is 300 mpa\u00b7s to 800 mpa\u00b7s, adding 80 mL of distilled water, and stirring constantly under 25\u00b0 C. until the sodium carboxymethylcellulose powder is completely dissolved; (2) dissolving 1.5 g of sodium periodate into 20 ml of distilled water, adding a solution thereof slowly into the flask, and continuing the reaction under 25\u00b0 C. for 24 hours; (3) adding 20 mL of glycol into the flask to stop the reaction; 30 minutes later, pouring a mixture thereof into a dialysis bag (MWCO 3500) and thoroughly dialyzing in distilled water; and finally obtaining a product of polyaldehyde cellulose by freeze drying.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 2.11111
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13809361', '15064317', '11784066', '12089797', '11430789']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.715199884368006
- 35 USC 102 Novelty (BERT): 0.5027168916613471
- Combined Prediction Score: 0.69395158509734
- Mean Citation Score: 185.595164
- Max Citation Score: 212.1728
- Similarity Product: 145.12168364257812

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test