PATENT CLAIM ANALYSIS

Application Number: 15779841
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["424", "186100"]

Abstract:
The present invention relates to improved methods and assays for the detection of AAV neutralizing antibodies in sera. The present invention provides safe, sensitive and high throughput neutralization assays for antibody detection.

Claim (Index 1):
A method of detecting AAV neutralizing antibodies in a serum sample by evaluating AAV neutralizing antibody mediated blockage of AAV entry to AAV permissive cells comprising\n (a) incubating an AAV vector with dilutions of a serum sample to form a mixture; (b) exposing AAV permissive cells to the mixture of step (a); (c) measuring the amount or quantity of AAV permissive cells which have been transduced; and (d) determining the AAV neutralizing antibody titer in the serum sample based on the measurement in (c).

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.2963
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10880297', '14360151', '14484842', '15681267', '15435212']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6673268445282751
- 35 USC 102 Novelty (BERT): 0.5072186228965783
- Combined Prediction Score: 0.6513160223651053
- Mean Citation Score: 234.679798
- Max Citation Score: 241.01613
- Similarity Product: 165.9919365772176

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test