PATENT CLAIM ANALYSIS

Application Number: 16101861
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["424", "158100"]

Abstract:
Antibodies that bind the apple 2 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa are described.

Claim (Index 1):
An antibody or antigen binding fragment comprising:\n at least the six complementarity determining regions (CDRs) of antibody \u03b1FXI-13654p, or \u03b1FXI-13716p; wherein antibody \u03b1FXI-13654p comprises a heavy chain (HC) having the amino acid sequence shown in SEQ ID NO:18, 26, 31, or 32 and a light chain (LC) having the amino acid sequence shown in SEQ ID NO:19; and wherein antibody \u03b1FXI-13716p comprises an HC having the amino acid sequence shown in SEQ ID NO:22, 27, 33, or 34 and a LC having the amino acid sequence shown in SEQ ID NO:23; wherein optionally one or more of the six CDRs has one, two, or three amino acid substitutions, additions, deletions, or combinations thereof; and, wherein the antibody or antigen binding fragment binds the apple 2 domain of coagulation factor XI (FXI) and inhibits activation of FXI.

Metadata:
- Claim Count in Document: 122.0
- Percentile: 96.0
- Lexical Diversity: 1.09091
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15409607', '15619620', '16335133', '15906773', '15934526']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7646385567009439
- 35 USC 102 Novelty (BERT): 0.6978351047294528
- Combined Prediction Score: 0.7579582115037948
- Mean Citation Score: 558.16293
- Max Citation Score: 887.4425699999997
- Similarity Product: 691.6536357550958

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test