PATENT CLAIM ANALYSIS

Application Number: 15884691
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["506", "009000"]

Abstract:
A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents and methods of diagnosing ovarian cancer include use of CLIC4 ligands and/or multiple tropomyosin ligands with an additional ovarian cancer biomarker. For example, CLIC4 combined with one or more of CLIC1 and/or one or multiple members of the tropomyosin family, e.g., TPM1, TPM2, TPM3 or TPM4, and further optionally including CTSD-30 kDa and/or PRDX-6, among other ovarian cancer biomarkers can form a characteristic diagnostic pattern or profile of expression that is diagnostic of the disease. Still other embodiments are described.

Claim (Index 2):
The method according to  claim 1 , further comprising:\n detecting or measuring in the sample or from a protein level profile generated from the sample, the protein levels of one or more additional ovarian cancer biomarkers; and comparing the protein levels of the additional biomarkers in relation to the levels of the additional biomarkers in the subject's sample with the same biomarkers in a reference standard or profile.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 86.0
- Lexical Diversity: 1.87619
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14045452', '11950416', '13397442', '15386714', '13372137']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5430304939894018
- 35 USC 102 Novelty (BERT): 0.7230429814117627
- Combined Prediction Score: 0.5610317427316379
- Mean Citation Score: 442.0482
- Max Citation Score: 979.633
- Similarity Product: 757.2918124001027

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test