PATENT CLAIM ANALYSIS

Application Number: 15981979
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "284000"]

Abstract:
A derivative of isocorydine of formula I: wherein: R 1 ═   X═N, C, C═C; n 1 =0, 1    R 2 ═H, R 1  Y═C, N R 3 ═H, Cl, Br, F, CF 3 , OCH 3 , CH 3 ,   Z ═H, Cl, F, N; n 2 =0, 1  R 4 ═NH 2 , CH 2 NH 2 , NHCO(CH 2 ) n3 CH 3 , CH 2 NHCO(CH 2 ) n3 CH 3 , n 3 =0, 1, 2.   This derivative is prepared by amidation condensation reaction between an amino group of NICD and a carbonyl group of an aryl isocyanate, a carboxylic acid, or an acid chloride, or symmetrical amidation condensation reaction between an NICD and an aromatic amino group by solid phosgene. This derivative has anti-cancer activity in vivo and in vitro, and may be used for preventing and treating cancer.

Claim (Index 13):
The method of  claim 4  comprising reacting NICD with the aromatic amine, wherein the following steps are conducted:\n step A: copolymerization reaction is performed between NICD and an aromatic amine in an organic solvent by solid phosgene or phosgene to form a ureido functional group: an arylamine, solid phosgene, and a condensation catalyst are added to an organic solvent solution of NICD to perform a condensation reaction with stirring, the solvent is recovered after the reaction is complete, and purification is conducted to obtain a resultant compound A; \n step B: the resultant compound A obtained in the step A is dissolved in an organic solvent, an aqueous alkali solution or protic acid is added to perform reaction with stirring, hydrolysis reaction of a protective group is performed, the solvent is recovered after the reaction is complete, and purification is conducted to obtain a resultant compound B; and \n step C: a carboxylic acid or an acid chloride is added to an organic solvent solution of the resultant compound B obtained in the step B, reaction is performed with stirring to form aminoacylation protection, the solvent is recovered after the reaction is complete, and purification is conducted to obtain the derivative.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 2.28947
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13699869', '15762985', '12767647', '13379497', '14263886']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7149278976352006
- 35 USC 102 Novelty (BERT): 0.5129357808247007
- Combined Prediction Score: 0.6947286859541506
- Mean Citation Score: 271.156108
- Max Citation Score: 283.43286
- Similarity Product: 219.43272976907016

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test