PATENT CLAIM ANALYSIS

Application Number: 15883798
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "653000"]

Abstract:
The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.

Claim (Index 1):
A ready to ready-to-inject norepinephrine composition, comprising:\n an aqueous acidic solution having a pH range of between 3.7 and 4.3, wherein the aqueous solution further comprises a chelating agent and a pharmaceutically acceptable salt; wherein the chelating agent is present in an amount of between 1 \u03bcg/ml and 100 \u03bcg/ml, and wherein the pharmaceutically acceptable salt is present in an amount of between 0.6 wt % and 1.2 wt %; norepinephrine dissolved at a concentration suitable for administration to a patient in need thereof, wherein the norepinephrine is an R-isomer; wherein the ready-to-administer norepinephrine composition is substantially free of antioxidants; and wherein the ready-to-administer norepinephrine composition is formulated such that after storage over at least three months equal or less than 10% of the R-isomer form will isomerize to the S-isomer and such that equal or less than 5% of the total norepinephrine will degrade to degradation products.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 1.2973
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14837749', '15663246', '13704145', '14668683', '15058602']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7205689039544915
- 35 USC 102 Novelty (BERT): 0.4990782889525942
- Combined Prediction Score: 0.6984198424543018
- Mean Citation Score: 204.382542
- Max Citation Score: 253.47609
- Similarity Product: 191.2197976471532

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test