PATENT CLAIM ANALYSIS

Application Number: 16142087
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-08
Patent Classification: ["514", "004300"]

Abstract:
The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Claim (Index 1):
A compound of Formula I: wherein:\n A is absent, \u2014(C\u2550O)\u2014, \u2014S(O) 2 \u2014, \u2014C(\u2550N\u2014OR 1 )\u2014 or \u2014C(\u2550N\u2014CN)\u2014; \n \u2003is selected from \u2014C 3 -C 12  cycloalkyl, substituted \u2014C 3 -C 12  cycloalkyl; \u2014C 3 -C 12  cycloalkenyl, substituted \u2014C 3 -C 12  cycloalkenyl; \u2014C 3 -C 12  heterocycloalkyl, and substituted \u2014C 3 -C 12  heterocycloalkyl; or \u2003is \u2003wherein R 7  and R 8  are each independently C 1 -C 8  alkyl or C 2 -C 8  alkenyl and are each independently optionally substituted with one or more halo; M 1  and M 2  are each independently selected from O or NR 1 ; each R 1  is independently selected at each occurrence from the group consisting of: (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; or substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) \u2014C 1 -C 8  alkyl, \u2014C 2 -C 8  alkenyl, or \u2014C 2 -C 8  alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; substituted \u2014C 1 -C 8  alkyl, substituted \u2014C 2 -C 8  alkenyl, or substituted \u2014C 2 -C 8  alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; \u2014C 3 -C 12  cycloalkyl, substituted \u2014C 3 -C 12  cycloalkyl; \u2014C 3 -C 12  cycloalkenyl, or substituted \u2014C 3 -C 12  cycloalkenyl; L 1  and L 2  are each independently selected from \u2014C 1 -C 8  alkylene, \u2014C 2 -C 8  alkenylene, or \u2014C 2 -C 8  alkynylene each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; substituted \u2014C 1 -C 8  alkylene, substituted \u2014C 2 -C 8  alkenylene, or substituted \u2014C 2 -C 8  alkynylene each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; \u2014C 3 -C 12  cycloalkylene, or substituted \u2014C 3 -C 12  cycloalkylene each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; \u2014C 3 -C 12  cycloalkenylene, and substituted \u2014C 3 -C 12  cycloalkenylene each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; W is absent, \u2014O\u2014, \u2014S\u2014, \u2014NH\u2014, \u2014N(Me)-, \u2014C(O)NH\u2014, or \u2014C(O)N(Me)-; X and Y taken together with the carbon atoms to which they are attached to form a cyclic moiety which selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocylic, carbocyclic, and substituted carbocyclic; X\u2032 is N or \u2014C(R 2 )\u2014, where R 2  is selected from the group consisting of: (i) hydrogen, halogen, CN, CF 3 , NO 2 , OR 3 , SR 3 , \u2014NHS(O) 2 \u2014R 3 , \u2014NH(SO 2 )NR 4 R 5 , NR 4 R 5 , CO 2 R 3 , COR 3 , CONR 4 R 5 , N(R 1 )COR 3 ; aryl; substituted aryl; heteroaryl; or substituted heteroaryl; (ii) heterocycloalkyl or substituted heterocycloalkyl; and (iii) \u2014C 1 -C 8  alkyl, \u2014C 2 -C 8  alkenyl, or \u2014C 2 -C 8  alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; substituted \u2014C 1 -C 8  alkyl, substituted \u2014C 2 -C 8  alkenyl, or substituted \u2014C 2 -C 8  alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; \u2014C 3 -C 12  cycloalkyl, substituted \u2014C 3 -C 12  cycloalkyl; \u2014C 3 -C 12  cycloalkenyl, or substituted \u2014C 3 -C 12  cycloalkenyl; each R 3  is independently selected from C 1 -C 8  alkyl, \u2014C 2 -C 8  alkenyl, or \u2014C 2 -C 8  alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N, substituted \u2014C 1 -C 8  alkyl, substituted \u2014C 2 -C 8  alkenyl, or substituted \u2014C 2 -C 8  alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; and \u2014C 3 -C 12  cycloalkyl, substituted \u2014C 3 -C 12  cycloalkyl; \u2014C 3 -C 12  cycloalkenyl, or substituted \u2014C 3 -C 12  cycloalkenyl; heterocylic; substituted heterocyclic; aryl; substituted aryl; heteroaryl; or substituted heteroaryl; each R 4  and R 5  are independently selected from H and R 3 , or R 4  and R 5  combined together with the N they are attached to form a heterocyclic ring; R and R\u2032 are each independently selected from the group consisting of: (i) \u2014C 1 -C 8  alkyl, \u2014C 2 -C 8  alkenyl, or \u2014C 2 -C 8  alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; substituted \u2014C 1 -C 8  alkyl, substituted \u2014C 2 -C 8  alkenyl, or substituted \u2014C 2 -C 8  alkynyl each containing 0, 1, 2, or 3 heteroatoms selected from O, S or N; \u2014C 3 -C 12  cycloalkyl, r substituted \u2014C 3 -C 12  cycloalkyl; \u2014C 4 -C 12  alkylcycloalkyl, substituted \u2014C 4 -C 12  alkylcycloalkyl; \u2014C 3 -C 12  cycloalkenyl, substituted \u2014C 3 -C 12  cycloalkenyl; \u2014C 4 -C 12  alkylcycloalkenyl, or substituted \u2014C 4 -C 12  alkylcycloalkenyl; (ii) aryl; substituted aryl; heteroaryl; or substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) hydrogen or deuterium; G is selected from \u2014OH, \u2014NHS(O) 2 \u2014R 3 , \u2014NH(SO 2 )NR 4 R 5 , and NR 4 R 5 ; and R\u2033 is selected from hydrogen, methyl, ethyl, and allyl.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 1.73846
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13237120', '14146161', '11835657', '11768723', '12324071']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8574277040730546
- 35 USC 102 Novelty (BERT): 0.5596306920001588
- Combined Prediction Score: 0.827648002865765
- Mean Citation Score: 436.1867679999999
- Max Citation Score: 441.28162
- Similarity Product: 389.5235321548104

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test