PATENT CLAIM ANALYSIS

Application Number: 15753318
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "440000"]

Abstract:
Chromatin 3D structure modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs, such as CTCF motifs. In certain example embodiments, the present invention may block formation of an loop anchor or chromatin domain or induce formation of a loop anchor or chromatin domain at a targeted genomic location. For instance, a loop anchor motif can be altered, such as by mutating (including inverting) a binding motif so as to remove such a motif, or by adding new binding motifs in new locations within a loop domain, so as to reduce the size of an existing loop, so as to modify the size of an existing loop, or combinations thereof. Alternatively, the chromatin 3D structure modulating agent may bind a target region and mask a loop anchor motif, thereby preventing a loop anchor or chromatin domain from forming. The chromatin 3D structure modulating agent may bind a target region and cause a loop anchor of chromatin domain to form.

Claim (Index 70):
A method of treatment\n comprising altering chromatin 3D structure or gene expression within a chromatin domain in a subject in need thereof suffering from a disease associated with aberrant chromatin 3D structure or aberrant gene expression within a chromatin domain; or comprising altering chromatin 3D structure around an inserted therapeutic gene in a subject in need thereof, in order to ensure proper regulation of the inserted therapeutic gene and the surrounding endogenous genes.

Metadata:
- Claim Count in Document: 72.0
- Percentile: 88.0
- Lexical Diversity: 2.30864
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14892911', '14916338', '15179912', '14105017', '15527790']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5052178566322811
- 35 USC 102 Novelty (BERT): 0.5027681331602633
- Combined Prediction Score: 0.5049728842850794
- Mean Citation Score: 257.984156
- Max Citation Score: 263.11386
- Similarity Product: 185.1193029487753

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test