PATENT CLAIM ANALYSIS

Application Number: 15984146
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "049000"]

Abstract:
The present disclosure provides compositions that include a nanoparticle and a compound that reduces the biological activity of one or more bromodomain and extra-terminal family member (BET) proteins (e.g., a bromodomain inhibitor), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell.

Claim (Index 8):
The composition of  claim 1 , wherein the compound that reduces the biological activity of one or more BET proteins comprises:\n (a) JQ1 ((S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate) (b) LY294002 (2-Morpholin-4-yl-8-phenylchromen-4-one) (c) a combination of (a) and (b); (d) (S)-2-(6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide (e) (6S)-4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide or\n (f) a combination of two or more of (a), (b), (d), and (e).

Metadata:
- Claim Count in Document: 51.0
- Percentile: 93.0
- Lexical Diversity: 1.4
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15807424', '14921230', '12772981', '14959105', '14651413']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7862309642557612
- 35 USC 102 Novelty (BERT): 0.5438883174205216
- Combined Prediction Score: 0.7619966995722373
- Mean Citation Score: 294.6769020000001
- Max Citation Score: 412.19766
- Similarity Product: 237.30879572307583

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test