PATENT CLAIM ANALYSIS

Application Number: 15752575
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "056000"]

Abstract:
The present invention discloses an ovine enoxaparin sodium, a preparation method therefor, and an application thereof. The ovine enoxaparin sodium is prepared from ovine heparin. Compared with enoxaparin sodium derived from porcine intestinal mucosa heparin, both the chemical structures (disaccharide compositions) and the physiochemical properties are different. Through process of optimization and precipitation, the ovine enoxaparin sodium prepared meets the enoxaparin sodium specifications in the USP 37 and the EP 8.0 as well as specifications in current editions of the USP 39 and the EP 8.6. Also provided are two types of ovine enoxaparin sodium injections, preparation methods therefor, and anticoagulation properties in animal model. The raw material used in the preparation is ovine, which is a Halal material compared to porcine enoxaparin sodium. Therefore, the ovine enoxaparin sodium and the injections thereof are an Halal anticoagulant medicine.

Claim (Index 9):
A method for preparing an ovine enoxaparin sodium, comprising the steps of:\n S1, pretreating: dissolving an ovine heparin sodium crude to obtain a solution, decolorizing the solution, filtering, then alcohol precipitating at room temperature, collecting a precipitate thereof, drying to obtain the ovine heparin; S2, preparing an ovine heparin quaternary ammonium salt: dissolving the ovine heparin obtained in S1 to obtain an aqueous solution, mixing the aqueous solution with an aqueous benzethonium chloride solution, filtering, washing and drying to obtain the ovine heparin quaternary ammonium salt; S3, preparing an ovine heparin benzyl ester: mixing the ovine heparin quaternary ammonium salt obtained in S2 with an organic solvent consisting of methylene chloride and benzyl chloride in a predetermined weight ratio for esterification to obtain an esterification mixture, dropwise adding a solution of sodium acetate methanol solution to the esterification mixture to generate an ovine heparin benzyl ester precipitate, filtering the ovine heparin benzyl ester precipitate, washing and drying to obtain the ovine heparin benzyl ester; and S4, preparing the ovine enoxaparin sodium: subjecting the ovine heparin benzyl ester obtained in S3 to an alkaline depolymerization, decoloring, neutralizing with an acid, alcohol precipitating, and drying to obtain the ovine enoxaparin sodium.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 88.0
- Lexical Diversity: 2.03947
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13982100', '11805829', '10386402', '13193977', '15735139']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.749299500491613
- 35 USC 102 Novelty (BERT): 0.516545038699691
- Combined Prediction Score: 0.7260240543124208
- Mean Citation Score: 234.99371
- Max Citation Score: 305.69705
- Similarity Product: 214.9705697273612

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test