PATENT CLAIM ANALYSIS

Application Number: 16216535
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["435", "007200"]

Abstract:
A method for evaluating a biological material for unassociated virus-size particles of exosomes having a particular epitope uses a fluorescent antibody stain specific for binding with the epitope and a fluid sample with the exosomes and fluorescent antibody stain is subjected to flow cytometry with identification of fluorescent emission detection events indicative of passage through a flow cell of a flow cytometer of unassociated labeled particles of virus size including such an exosome and fluorescent antibody stain.

Claim (Index 1):
A method for evaluating a biological material sample for unassociated virus-size particles in the form of exosomes having a particular epitope, the method comprising:\n subjecting to flow cytometry a fluid sample comprising at least a portion of the biological material sample, wherein the fluid sample comprises a fluorescent antibody stain capable of binding, directly or indirectly, with the particular epitope on the exosomes to form unassociated labeled particles of virus size including a said exosome and the fluorescent antibody stain, the fluorescent antibody stain having a fluorescent emission response when subjected to an excitation radiation, the flow cytometry comprising:\n flowing the fluid sample through a flow cell of a flow cytometer; \n subjecting the fluid sample flowing through the flow cell to the excitation radiation causing the fluorescent emission response from the fluorescent antibody stain; and \n detecting radiation from the flow cell within a wavelength range of the fluorescent emission response and evaluating the detected radiation within the wavelength range to identify fluorescent emission detection events indicative of passage through the flow cell of the unassociated labeled particles of virus size, each said unassociated labeled particle including a said exosome with the epitope and the fluorescent antibody stain; and \n wherein the flow cytometry comprises detecting only for fluorescent emissions from fluorescent stains, and the flow cytometry is in the absence of particle identification by light scatter detection.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 98.0
- Lexical Diversity: 1.625
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16215153', '15713314', '15123544', '15713154', '15558107']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7502413826100764
- 35 USC 102 Novelty (BERT): 0.6650135463326302
- Combined Prediction Score: 0.7417185989823318
- Mean Citation Score: 659.905424
- Max Citation Score: 674.64197
- Similarity Product: 643.9430793642058

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test