PATENT CLAIM ANALYSIS

Application Number: 16028979
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["435", "060000"]

Abstract:
The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z 1 , Z 2 , R 1 , R 4 , R 5  and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Claim (Index 1):
A method of treating a disease in which inhibition of PKB is beneficial, comprising: administering to a person in need thereof a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein: Y represents CH or N; Z 1 -Z 2  represents a group selected from C(R 6 )\u2550CH, N\u2550CH and C(R 6 )\u2550N; where R 6  represents hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, difluoromethyl, trifluoromethyl or cyclopropyl; n is 0, 1 or 2; R 1  represents C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 1-4 alkoxyC 1-4 alkyl, fluoroC 1-4  alkyl, aminoC 1-4  alkyl, hydroxyC 1-4  alkyl, cyano, cyanoC 1-4  alkyl, C 3-6  cycloalkyl, \u2014(CH 2 ) p NHCOCH 3 , \u2014(CH 2 ) p NHSO 2 CH 3 , \u2014(CH 2 ) p NHCONH 2 , \u2014(CH 2 ) p NHCONR 2 R 3 , \u2014(CH 2 ) p NR 2 R 3 , \u2014(CH 2 ) p SO 2 NH 2 , \u2014(CH 2 ) p SO 2 NR 2 R 3 , \u2014(CH 2 ) p CONH 2 , \u2014(CH 2 ) p CONR 2 R 3  or \u2014(CH 2 ) p \u2014R 7 ; where\n p is 0, 1, 2 or 3; \n R 2  represents hydrogen or C 1-3  alkyl; \n R 3  represents C 1-3 alkyl; and \n R 7  represents phenyl; \n R 7  represents a 5 or 6 membered monocyclic heteroaryl ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S; or \n R 7  represents a monocyclic 4, 5, or 6 membered heterocyclic ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S; \n wherein R 7  is optionally substituted by 1 or 2 substituents selected from C 1-4 alkyl, trifluoromethyl, C 1-4 alkoxy, fluoro, chloro, bromo, and cyano; \n R 4  represents hydrogen, fluoro, chloro, bromo, cyano or trifluoromethyl; and R 5  represents hydrogen, fluoro, chloro or bromo.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 95.0
- Lexical Diversity: 1.65079
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15351481', '12249477', '14626303', '11577963', '14017814']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6517634918467798
- 35 USC 102 Novelty (BERT): 0.5446477588382959
- Combined Prediction Score: 0.6410519185459315
- Mean Citation Score: 362.572456
- Max Citation Score: 426.66403
- Similarity Product: 286.1982588390881

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test