PATENT CLAIM ANALYSIS

Application Number: 16157930
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["435", "347000"]

Abstract:
The present disclosure provides co-cultures of human pluripotent stem cell derived hepatocytes and at least one non-parenchymal cell population in vitro, methods of preparing the co-cultures and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The stem cell derived hepatocyte co-culture system provides an in vitro model in which cell viability and relatively mature hepatocyte phenotype of stem cell derived hepatocytes are maintained for extended periods relative to conventional monoculture.

Claim (Index 11):
The method of  claim 8 , wherein the at least one indicator of hepatic function is at least one of the liver enzymes selected from CYP2C9 (luciferin-H), CYP3A4 (luciferin-IPA), a combination of CYP1A1, CYP1A2, CYP2B6 and CYP2D6 (luciferin ME-EGE), and any combination thereof.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 97.0
- Lexical Diversity: 1.54902
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14596787', '13267866', '15006754', '14772284', '13772802']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6125658488362477
- 35 USC 102 Novelty (BERT): 0.6773430062517236
- Combined Prediction Score: 0.6190435645777953
- Mean Citation Score: 434.565556
- Max Citation Score: 874.7666
- Similarity Product: 633.5386204652548

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test