PATENT CLAIM ANALYSIS

Application Number: 15956133
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-04
Patent Classification: ["514", "017700"]

Abstract:
Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

Claim (Index 57):
The method of  claim 1 , wherein the necrosis inhibitor is a compound of Formula VIII: or a pharmaceutically acceptable salt, an ester, or a prodrug thereof, wherein: each X 1 , X 2 , X 3 , X 4 , X 5 , and X 6  is selected, independently, from N or CR X1 ; each Y 1 , Y 2 , and Y 3  is selected, independently, from O, S, NR Y1 , or CR Y2 R Y3 ; each Z 1  and Z 2  is selected, independently, from O, S, or NR Z1 ; each R Y1  and R Z1  is selected, independently, from H, optionally substituted C 1 -C 6 alkyl, optionally substituted C 2 -C 6 alkenyl, optionally substituted C 2 -C 6 alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, \u2014C(\u2550O)R 5A , \u2014C(\u2550O)OR 5A , or \u2014C(\u2550O)NR 5A R 6A ; each R X1 , R Y2 , and R Y3  is selected, independently, from H, halogen, CN, NC, NO 2 , N 3 , OR 3 , SR 3 , NR 3 R 4 , \u2014C(\u2550O)R 5A , \u2014C(\u2550O)OR 5A , \u2014C(\u2550O)NR 5A R 6A , \u2014S(\u2550O)R 5A , \u2014S(\u2550O) 2 OR 5A , \u2014S(\u2550O) 2 OR 5A , \u2014S(\u2550O) 2 OR 5A R 6A , optionally substituted C 1 -C 6 alkyl, optionally substituted C 2 -C 6 alkenyl, optionally substituted C 2 -C 6 alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; each R 1 , R 2  R 5A , R 5B , R 6A , and R 6B  is selected from H, optionally substituted C 1 -C 6  alkyl, optionally substituted C 2 -C 6 alkenyl, optionally substituted C 2 -C 6 alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; or R 5A  and R 6A , or R 5B  and R 6B  combine to form a heterocyclyl; and each R 3  and R 4  is selected from H, optionally substituted C 1 -C 6  alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, \u2014C(\u2550O)R 5B , \u2014C(\u2550S)R 5B , \u2014C(\u2550NR 6B )R 5B , \u2014C(\u2550O)OR 5B , \u2014C(\u2550O)NR 5B R 6B , \u2014S(\u2550O)R 5B , \u2014S(\u2550O) 2 R 5B , \u2014S(\u2550O) 2 OR 5B , or \u2014S(\u2550O) 2 NR 5B R 6B .

Metadata:
- Claim Count in Document: 73.0
- Percentile: 91.0
- Lexical Diversity: 1.66102
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15093480', '15288214', '14934810', '12086792', '15100967']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7795901279800435
- 35 USC 102 Novelty (BERT): 0.7410085495473417
- Combined Prediction Score: 0.7757319701367733
- Mean Citation Score: 535.4984059999998
- Max Citation Score: 823.15753
- Similarity Product: 808.6928213801735

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test