PATENT CLAIM ANALYSIS

Application Number: 15915987
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["435", "006100"]

Abstract:
The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of hypermethylated DNA. The detection of CpG methylation in marker DNA is useful for the diagnosis of cancers and the invention provides improved methods for this purpose. These improved methods allow in particular for a more sensitive detection of methylated marker DNA with high backgrounds of unmethylated marker DNA.

Claim (Index 23):
A kit comprising\n (i) a pair of methylation non-specific primers comprising the nucleic acid sequences of SEQ ID NOs: 121 and 122 or variants thereof, wherein the variants are shifted up to 5 nucleotides upstream or downstream on a bisulfite-converted target DNA sequence that the respective primer anneals to, wherein the bisulfite-converted target DNA sequence consists of at least one of the sequences of SEQ ID NO:102, 104 or complements thereof, and/or wherein the variants are up to 5 nucleotides shorter while still annealing to the bisulfite-converted target DNA sequence of the respective primers; and (ii) at least one methylation-specific blocker, wherein the methylation-specific blocker comprises the nucleic acid sequence of SEQ ID NOs: 123 or 124 or a variant thereof, wherein the variant is shifted up to 5 nucleotides upstream or downstream on the bisulfite-converted target DNA sequence that the respective blocker anneals to, and/or wherein the variant is up to 5 nucleotides shorter while still annealing to the bisulfite-converted target DNA sequence.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.62791
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15436436', '09887941', '11415322', '12848239', '11630620']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6635448226676793
- 35 USC 102 Novelty (BERT): 0.6383580180990759
- Combined Prediction Score: 0.661026142210819
- Mean Citation Score: 465.561808
- Max Citation Score: 766.7551
- Similarity Product: 551.7672239903152

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test