PATENT CLAIM ANALYSIS

Application Number: 15758042
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "071300"]

Abstract:
The present invention relates to a method for producing a botulinum toxin comprising:(a) treating a culture of a botulinum toxin-producing strain with acid to form a botulinum toxin-containing precipitate; (b) adding a buffer to the botulinum toxin-containing precipitate of step (a), followed by clarification by at least one method selected from the group consisting of depth filtration (DF), microfiltration (MF), ultrafiltration (UF), sterile filtration, membrane chromatography (MC) and centrifugation; (c) subjecting the botulinum toxin-containing solution of step (b) to UF diafiltration, ammonium sulfate precipitation or hydrochloric acid precipitation, and then diluting a retentate resulting from the UF diafiltration in a buffer or dissolving a precipitate resulting from the ammonium sulfate precipitation or hydrochloric acid precipitate in a buffer; and (d) subjecting the retentate dilution, ammonium sulfate precipitate solution or hydrochloric acid precipitate solution of step (c) to anion-exchange chromatography (AEX) to purify the botulinum toxin.

Claim (Index 25):
The method of  claim 16 , wherein the botulinum toxin in step (f) is collected as a botulinum toxin-containing fraction of a flow-through (FT) fraction eluted from anion-exchange chromatography, or collected as a fraction containing the botulinum toxin bound to anion exchange chromatography resin.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 2.40789
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14654819', '14961327', '12502181', '15664456', '13344399']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6975074400746111
- 35 USC 102 Novelty (BERT): 0.5537730911366758
- Combined Prediction Score: 0.6831340051808176
- Mean Citation Score: 365.340544
- Max Citation Score: 475.80542
- Similarity Product: 296.2496793811692

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test