PATENT CLAIM ANALYSIS

Application Number: 16162835
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-06
Patent Classification: ["544", "360000"]

Abstract:
The invention relates to triazole compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Claim (Index 29):
A compound or a pharmaceutically acceptable salt thereof, selected from the following table: 1. 2. 1-(3,5-difluorophenyl)-N-[3-(3-methoxyazetidin-1-yl)- 5-methyl-phenyl]-1,2,4-triazol-3-amine 3. 4. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-(trifluoromethyl)phenyl]piperazin-2- yl]cyclobutanol 5. N-[3-chloro-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]- 1-(3,5-difluorophenyl)-1,2,4-triazol-3-amine 6. 3-methyl-1-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]pyrrolidin-3-ol 7. N-[3-methyl-5-(6-oxa-2-azaspiro[3.3]heptan-2- yl)phenyl]-1-phenyl-1,2,4-triazol-3-amine 8. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]-5- methyl-N1-tetrahydrofuran-3-yl-benzene-1,3-diamine 9. 10. N-[3,5-di(tetrahydropyran-4-yl)phenyl]-1-phenyl- 1,2,4-triazol-3-amine 11. N-[3-methyl-5-(2-oxa-7-azaspiro[3.5]nonan-7- yl)phenyl]-1-phenyl-1,2,4-triazol-3-amine 12. methyl 4-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]piperidine-1-carboxylate 13. N-[3-(4-methylpiperazin-1-yl)-5- (trifluoromethyl)phenyl]-1-(4-pyridyl)-1,2,4-triazol-3- amine 14. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1- (4-fluorophenyl)-1,2,4-triazol-3-amine 15. N-[3-ethyl-5-(3-morpholinoazetidin-1-yl)phenyl]-1-(3- fluorophenyl)-1,2,4-triazol-3-amine 16. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1- (2-fluoro-4-pyridyl)-1,2,4-triazol-3-amine 17. N-[3-tert-butyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3- amine 18. N-[3-[3-fluoro-1-(oxetan-3-yl)pyrrolidin-3-yl]-5- methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 19. 1-(3,5-difluorophenyl)-N-[3-(6,8-dihydro-5H- imidazo[1,2-a]pyrazin-7-yl)-5-methyl-phenyl]-1,2,4- triazol-3-amine 20. N-[3-(4-cyclopropylpiperazin-1-yl)-5-methyl-phenyl]- 1-pyrazin-2-yl-1,2,4-triazol-3-amine 21. N-[3-(2,5-dimethylpiperazin-1-yl)-5-methyl-phenyl]-1- phenyl-1,2,4-triazol-3-amine 22. 23. 1-(3,5-difluorophenyl)-N-[3-(3-fluoro-1-methyl- pyrrolidin-3-yl)-5-methyl-phenyl]-1,2,4-triazol-3- amine 24. 1-(5-fluoro-3-pyridyl)-N-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 25. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[1-(oxetan-3- yl)pyrrolidin-3-yl]phenyl]-1,2,4-triazol-3-amine 26. N-[3-(difluoromethyl)-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 27. 1-(3-fluorophenyl)-N-(3-methyl-5-morpholino- phenyl)-1,2,4-triazol-3-amine 28. 1-(2,4-difluorophenyl)-N-[3-fluoro-5-(4-methyl-1,4- diazepan-1-yl)phenyl]-1,2,4-triazol-3-amine 29. N-[3-[(8aR)-4-isobutyl-3,4,6,7,8,8a-hexahydro-1H- pyrrolo[1,2-a]pyrazin-2-yl]-5-methyl-phenyl]-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 30. 1-(2-methoxypyrimidin-4-yl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 31. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1- (p-tolyl)-1,2,4-triazol-3-amine 32. 1-(3-chloro-5-fluoro-phenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 33. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 34. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(1S,4S)-2- (oxetan-3-yl)-2,5-diazabicyclo[2.2.1]heptan-5- yl]phenyl]-1,2,4-triazol-3-amine 35. 36. 1-(3-fluorophenyl)-N-[3-methyl-5-[1-(oxetan-3- yl)azetidin-3-yl]phenyl]-1,2,4-triazol-3-amine 37. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 38. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]-5- methyl-N1-[1-(oxetan-3-yl)-4-piperidyl]benzene-1,3- diamine 39. N-(3-methyl-5-pyrrolidin-3-yl-phenyl)-1-phenyl-1,2,4- triazol-3-amine 40. 1-(2-fluoro-4-pyridyl)-N-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 41. 1-[3-[2-(ethoxymethyl)pyrrolidin-1-yl]-5-fluoro- phenyl]-N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1,2,4-triazol-3-amine 42. 1-(2-chloro-4-pyridyl)-N-(3-methyl-5-pyrrolidin-1-yl- phenyl)-1,2,4-triazol-3-amine 43. 1-(3,4-difluorophenyl)-N-(3-methyl-5-morpholino- phenyl)-1,2,4-triazol-3-amine 44. 45. N-(3-methyl-5-morpholino-phenyl)-1-phenyl-1,2,4- triazol-3-amine 46. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[(3R)-1-(oxetan- 3-yl)pyrrolidin-3-yl]oxy-phenyl]-1,2,4-triazol-3-amine 47. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 48. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1- pyrazin-2-yl-1,2,4-triazol-3-amine 49. N-(3-fluoro-5-morpholino-phenyl)-1-(2-fluorophenyl)- 1,2,4-triazol-3-amine 50. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1- (5-fluoropyrimidin-4-yl)-1,2,4-triazol-3-amine 51. N-[3-[1-[3-(benzenesulfonylmethyl)oxetan-3-yl]-4- piperidyl]-5-methyl-phenyl]-1-phenyl-1,2,4-triazol-3- amine 52. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[(3S)-1-(oxetan- 3-yl)pyrrolidin-3-yl]oxy-phenyl]-1,2,4-triazol-3-amine 53. [4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1-methyl-piperazin-2- yl]methanol 54. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]- 1-(4-methyl-2-pyridyl)-1,2,4-triazol-3-amine 55. 1-(3-chlorophenyl)-N-[3-cyclopropyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 56. 1-(3-fluoro-5-methoxy-phenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 57. 58. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1- (6-methylpyrimidin-4-yl)-1,2,4-triazol-3-amine 59. [4-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]piperazin-2-yl]methanol 60. N-[3-methyl-5-(1-methyl-3-piperidyl)phenyl]-1- phenyl-1,2,4-triazol-3-amine 61. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[1-(oxetan-3-yl)- 3,6-dihydro-2H-pyridin-4-yl]phenyl]-1,2,4-triazol-3- amine 62. N-[3-(difluoromethyl)-5-piperazin-1-yl-phenyl]-1- phenyl-1,2,4-triazol-3-amine 63. 1-(3,5-difluorophenyl)-N-[3-(4-methylpiperazin-1-yl)- 5-(trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 64. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]- 1-(2-methylsulfanylpyrimidin-4-yl)-1,2,4-triazol-3- amine 65. N-[3-methyl-5-[1-(oxetan-3-yl)azetidin-3-yl]phenyl]-1- phenyl-1,2,4-triazol-3-amine 66. 2,5-difluoro-4-[3-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]anilino]-1,2,4-triazol-1- yl]benzonitrile 67. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-4-(oxetan-3-yl)piperazin- 2-one 68. N-[3-methyl-5-(4-methylpiperazin-1-yl)phenyl]-1- pyrazin-2-yl-1,2,4-triazol-3-amine 69. 1-(3,4-difluorophenyl)-N-[3-ethyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 70. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]- 1-(p-tolyl)-1,2,4-triazol-3-amine 71. N-[3-methyl-5-[1-(oxetan-3-yl)-4-piperidyl]phenyl]-1- phenyl-1,2,4-triazol-3-amine 72. ethyl 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]acetate 73. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3-fluoro-5-methyl-phenyl)-1,2,4-triazol- 3-amine 74. N-[3-methyl-5-[1-(oxetan-3-yl)-3-piperidyl]phenyl]-1- pyrazin-2-yl-1,2,4-triazol-3-amine 75. N-[3-[4-(3,3-difluorocyclobutyl)piperazin-1-yl]-5- methyl-phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 76. 1-methyl-4-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]piperazin-2-one 77. 1-(3,5-difluorophenyl)-N-(3-methyl-5-piperazin-1-yl- phenyl)-1,2,4-triazol-3-amine 78. N-[3-[(1S,4S)-2-cyclopropyl-2,5- diazabicyclo[2.2.1]heptan-5-yl]-5-methyl-phenyl]-1- (3,5-difluorophenyl)-1,2,4-triazol-3-amine 79. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]propane- 1,3-diol 80. N-(3-fluoro-5-morpholino-phenyl)-1-phenyl-1,2,4- triazol-3-amine 81. 4-[3-[3-methyl-5-(4-methylpiperazin-1-yl)anilino]- 1,2,4-triazol-1-yl]benzonitrile 82. N-[3-(difluoromethyl)-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3- amine 83. 1-(2-fluorophenyl)-N-(3-fluoro-5-pyrrolidin-1-yl- phenyl)-1,2,4-triazol-3-amine 84. N-(3-methyl-5-morpholino-phenyl)-1-(4-pyridyl)- 1,2,4-triazol-3-amine 85. N-[3-(difluoromethyl)-5-morpholino-phenyl]-1-(2- fluoro-4-pyridyl)-1,2,4-triazol-3-amine 86. 1-(3-methoxyphenyl)-N-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 87. N-[3-(4-cyclopentylpiperazin-1-yl)-5-methyl-phenyl]- 1-phenyl-1,2,4-triazol-3-amine 88. 89. N-[3-(1,1-dioxo-1,4-thiazinan-4-yl)-5-methyl-phenyl]- 1-phenyl-1,2,4-triazol-3-amine 90. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1-piperidyl]ethanone 91. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1- (2-methylpyrimidin-4-yl)-1,2,4-triazol-3-amine 92. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(3S)-1-(oxetan- 3-yl)pyrrolidin-3-yl)phenyl]-1,2,4-triazol-3-amine 93. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino)-5-methyl-phenyl]piperazin-2-one 94. 1-(3-methoxypheny1)-N-[3-methyl-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 95. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(thietan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 96. N-[3-(4-methylpiperazin-1-yl)-5- (trifluoromethyl)phenyl]-1-pyrimidin-4-yl-1,2,4- triazol-3-amine 97. N-[3-tert-butyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3-fluorophenyl)-1,2,4-triazol-3-amine 98. N-[3-fluoro-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-1- (3-fluorophenyl)-1,2,4-triazol-3-amine 99. 1-(3,4-difluorophenyl)-N-(3-fluoro-5-pyrrolidin-1-yl- phenyl)-1,2,4-triazol-3-amine 100. 101. (3S)-3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-phenyl]-1-(oxetan-3- yl)pyrrolidin-3-ol 102. 1-(4-fluorophenyl)-N-[3-methoxy-5-[4-(oxetan- 3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 103. 1-[3-(2-ethylpyrrolidin-1-yl)-5-fluoro-phenyl]- N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]- 1,2,4-triazol-3-amine 104. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2-pyridyl)-1,2,4-triazol-3-amine 105. 106. 107. 1-(3,5-difluorophenyl)-N-[3-ethyl-5-[4-(oxetan- 3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 108. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(4- piperidyl)phenyl]-1,2,4-triazol-3-amine 109. N-[3-[3-(dimethylamino)pyrrolidin-1-yl]-5- fluoro-phenyl]-1-(3-fluorophenyl)-1,2,4-triazol-3- amine 110. N-(3-methyl-5-pyrrolidin-1-yl-phenyl)-1- phenyl-1,2,4-triazol-3-amine 111. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(6-methylpyrimidin-4-yl)-1,2,4-triazol-3- amine 112. 1-(3,5-difluorophenyl)-N-[3-fluoro-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 113. N3-[1-(3,4-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-[1-(oxetan-3-yl)pyrrolidin-3-yl]benzene- 1,3-diamine 114. 1-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-3-piperidyl]pyrrolidin-2- one 115. 1-[3-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]anilino]-1-piperidyl]ethanone 116. 1-(3,5-difluorophenyl)-N-[3-[3- (methoxymethyl)azetidin-1-yl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 117. 1-[3-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]-1-piperidyl]ethanone 118. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 119. 1-(3,5-difluorophenyl)-N-[3-(3,4- dimethylpiperazin-1-yl)-5-methyl-phenyl]-1,2,4- triazol-3-amine 120. N-[3-(1-cyclopropyl-4-piperidyl)-5-methyl- phenyl]-1-phenyl-1,2,4-triazol-3-amine 121. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(2,6-difluoro-4-pyridyl)-1,2,4-triazol-3- amine 122. 1-(2-fluoro-4-pyridyl)-N-[3-[4- (methoxymethyl)-1-piperidyl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 123. 2-[(2S)-4-[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5- (trifluoromethyl)phenyl]piperazin-2-yl]propan-2-ol 124. N-(3-ethyl-5-piperazin-1-yl-phenyl)-1-pyrazin- 2-yl-1,2,4-triazol-3-amine 125. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]acetic acid 126. N-[3-[4-(3-deuteriooxetan-3-yl)piperazin-1-yl]- 5-methyl-phenyl]-1-(3-fluorophenyl)-1,2,4-triazol-3- amine 127. N-[3-methyl-5-[4-(2-methyltetrahydrofuran-3- yl)piperazin-1-yl]phenyl]-1-phenyl-1,2,4-triazol-3- amine 128. N-[3-[(8aR)-3,4,6,7,8,8a-hexahydro-1H- pyrrolo[1,2-a]pyrazin-2-yl]-5-methyl-phenyl]-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 129. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(2,6-dimethylpyrimidin-4-yl)-1,2,4- triazol-3-amine 130. 1-(3,5-difluorophenyl)-N-[3-[4-(oxetan-3- yl)piperazin-1-yl]-5-(trifluoromethyl)phenyl]-1,2,4- triazol-3-amine 131. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(oxetan- 3-yl)phenyl]-1,2,4-triazol-3-amine 132. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2-methylsulfanylpyrimidin-4-yl)-1,2,4- triazol-3-amine 133. N-[3-(3,4-dimethylpiperazin-1-yl)-5-methyl- phenyl]-1-phenyl-1,2,4-triazol-3-amine 134. 1-(5-chloro-3-pyridyl)-N-[3-cyclopropyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 135. 136. N-[3-methyl-5-[4-(3-methyloxetan-3- yl)piperazin-1-yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol- 3-amine 137. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(4- tetrahydrofuran-3-ylpiperazin-1-yl)phenyl]-1,2,4- triazol-3-amine 138. N-[3-methyl-5-(4-methylpiperazin-1- yl)phenyl]-1-(2-pyridyl)-1,2,4-triazol-3-amine 139. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)-4-oxido-piperazin-4-ium-1-yl]phenyl]- 1,2,4-triazol-3-amine 140. 2-fluoro-4-[3-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]anilino]-1,2,4-triazol-1- yl]benzonitrile 141. 1-(3-chlorophenyl)-N-[3-methyl-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 142. 1-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]piperidine-4-carbonitrile 143. methyl 3-[3-methyl-5-[(1-phenyl-1,2,4-triazol- 3-yl)amino]phenyl]piperidine-1-carboxylate 144. 1-[4-[3-(difluoromethyl)-5-[(1-phenyl-1,2,4- triazol-3-yl)amino]phenyl]piperazin-1-yl]ethanone 145. 146. 1-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]piperidine-3-carbonitrile 147. 1-(3-fluorophenyl)-N-[3-methyl-5-(oxetan-3- yl)phenyl]-1,2,4-triazol-3-amine 148. N-[3-[4-(2-methoxyethyl)-1-piperidyl]-5- methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 149. N-[3-(4-cyclopropylpiperazin-1-yl)-5-methyl- phenyl]-1-phenyl-1,2,4-triazol-3-amine 150. 151. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(1- methyl-4-piperidyl)phenyl]-1,2,4-triazol-3-amine 152. N-[3-[(8aR)-4-isobutyl-3,4,6,7,8,8a-hexahydro- 1H-pyrrolo[1,2-a]pyrazin-2-yl]-5-methyl-phenyl]-1- phenyl-1,2,4-triazol-3-amine 153. N-[3-(4-cyclopropylpiperazin-1-yl)-5- (difluoromethyl)phenyl]-1-(2-fluoro-4-pyridyl)-1,2,4- triazol-3-amine 154. 1-(6-fluoro-2-pyridyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 155. 4-[3-(3-methyl-5-morpholino-anilino)-1,2,4- triazol-1-yl]pyridin-2-ol 156. 157. N-[3-[(8aR)-3,4,6,7,8,8a-hexahydro-1H- pyrrolo[1,2-a]pyrazin-2-yl]-5-methyl-phenyl]-1- phenyl-1,2,4-triazol-3-amine 158. N-(3-fluoro-5-morpholino-phenyl)-1-(3- fluorophenyl)-1,2,4-triazol-3-amine 159. N-(3-methyl-5-piperazin-1-yl-phenyl)-1- phenyl-1,2,4-triazol-3-amine 160. N-[3-methyl-5-[1-(oxetan-3-yl)-2,5- dihydropyrrol-3-yl]phenyl]-1-phenyl-1,2,4-triazol-3- amine 161. 1-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-4-piperidyl]pyrrolidin-2- one 162. 1-(3,5-difluorophenyl)-N-[3-[4- (methoxymethyl)-1-piperidyl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 163. 4-[3-[3-(difluoromethyl)-5-[4-(oxetan-3- yl)piperazin-1-yl]anilino]-1,2,4-triazol-1-yl]-1H- pyridin-2-one 164. 1-(3,5-difluorophenyl)-N-[3-(3- methoxypyrrolidin-1-yl)-5-methyl-phenyl]-1,2,4- triazol-3-amine 165. N-(3-morpholino-5-tetrahydrofuran-3-yl- phenyl)-1-phenyl-1,2,4-triazol-3-amine 166. N-[3-fluoro-5-(1,4-oxazepan-4-yl)phenyl]-1-(3- fluorophenyl)-1,2,4-triazol-3-amine 167. 1-(4-fluorophenyl)-N-(3-fluoro-5-pyrrolidin-1- yl-phenyl)-1,2,4-triazol-3-amine 168. N-(3-bromo-5-morpholino-phenyl)-1-phenyl- 1,2,4-triazol-3-amine 169. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)-1-piperidyl]phenyl]-1,2,4-triazol-3-amine 170. 171. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(6-oxa-2- azaspiro[3.3]heptan-2-yl)phenyl]-1,2,4-triazol-3-amine 172. N-[3-methyl-5-(4-tetrahydropyran-3- ylpiperazin-1-yl)phenyl]-1-phenyl-1,2,4-triazol-3- amine 173. 1-(3,5-difluorophenyl)-N-[3-ethyl-5-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 174. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrimidin-4-yl-1,2,4-triazol-3-amine 175. 1-(3-fluorophenyl)-N-[3-[4-(oxetan-3- yl)piperazin-1-yl]-5-(trifluoromethyl)phenyl]-1,2,4- triazol-3-amine 176. N-[3-(4-cyclopropylpiperazin-1-yl)-5-methyl- phenyl]-1-pyrimidin-4-yl-1,2,4-triazol-3-amine 177. N1-(azetidin-3-yl)-N3-[1-(2,4-difluorophenyl)- 1,2,4-triazol-3-yl]-5-fluoro-benzene-1,3-diamine 178. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(3R)-1- (oxetan-3-yl)pyrrolidin-3-yl]oxy-phenyl]-1,2,4-triazol- 3-amine 179. N-[3-methyl-5-(4-methyl-1,4-diazepan-1- yl)phenyl]-1-phenyl-1,2,4-triazol-3-amine 180. N-[3-methyl-5-[1-(oxetan-3-yl)-3- piperidyl]phenyl]-1-pyrimidin-4-yl-1,2,4-triazol-3- amine 181. N-(3-fluoro-5-morpholino-phenyl)-1-[3- (trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 182. N1-[1-(3-methoxypropyl)-4-piperidyl]-5- methyl-N3-(1-phenyl-1,2,4-triazol-3-yl)benzene-1,3- diamine 183. 1-(3,4-difluorophenyl)-N-[3-methoxy-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 184. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(2-fluoro-4-pyridyl)-1,2,4-triazol-3- amine 185. 1-(3,5-difluorophenyl)-N-[3-methyl-5- [(1R,4R)-2-(oxetan-3-yl)-2,5- diazabicyclo[2.2.1]heptan-5-yl]phenyl]-1,2,4-triazol-3- amine 186. 4-[3-(3-methyl-5-pyrrolidin-1-yl-anilino)-1,2,4- triazol-1-yl]benzonitrile 187. 1-[3-[[ethyl(methyl)amino]methyl]-5-fluoro- phenyl]-N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1,2,4-triazol-3-amine 188. N3-[1-(3-fluorophenyl)-1,2,4-triazol-3-yl]-5- methyl-N1-[1-(oxetan-3-yl)pyrrolidin-3-yl]benzene- 1,3-diamine 189. N-[3-(difluoromethyl)-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1-(2-fluoro-4-pyridyl)-1,2,4- triazol-3-amine 190. N-(3-methyl-5-pyrrolidin-1-yl-phenyl)-1-[3- (trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 191. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-[4-(trifluoromethyl)phenyl]-1,2,4-triazol- 3-amine 192. N3-[1-(3-fluorophenyl)-1,2,4-triazol-3-yl]-5- methyl-N1-[1-(oxetan-3-yl)-4-piperidyl]benzene-1,3- diamine 193. 1-(3,5-difluorophenyl)-N-[3-[3-fluoro-1- (oxetan-3-yl)pyrrolidin-3-yl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 194. 1-[4-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]-1-piperidyl]ethanone 195. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 196. ethyl 4-[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5-methyl-phenyl]piperazine-1- carboxylate 197. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1,5-dimethyl-N1-(oxetan-3-yl)benzene-1,3-diamine 198. 1-(3,4-difluorophenyl)-N-[3-ethyl-5-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 199. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(4- tetrahydropyran-3-ylpiperazin-1-yl)phenyl]-1,2,4- triazol-3-amine 200. 7-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-5,6,8,8a-tetrahydro-1H- oxazolo[3,4-a]pyrazin-3-one 201. 1-(4-fluorophenyl)-N-[3-methyl-5-[[1-(oxetan- 3-yl)-4-piperidyl]oxy]phenyl]-1,2,4-triazol-3-amine 202. 203. N-[3-fluoro-5-(4-methylpiperazin-1-yl)phenyl]- 1-(3-fluorophenyl)-1,2,4-triazol-3-amine 204. 1-(2-ethoxypyrimidin-4-yl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 205. 1-(3-fluoro-5-isopropoxy-phenyl)-N-[3-methyl- 5-(4-methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3- amine 206. 1-(3-ethyl-5-fluoro-phenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 207. N-[3-methyl-5-[1-(oxetan-3-y1)-3- piperidyl]phenyl]-1-(2-pyridyl)-1,2,4-triazol-3-amine 208. 1-(3,5-difluorophenyl)-N-[3-[(3S,4R)-3-fluoro- 1-(oxetan-3-yl)-4-piperidyl]-5-methyl-phenyl]-1,2,4- triazol-3-amine; 1-(3,5-difluorophenyl)-N-[3-[(3R,4S)- 3-fluoro-1-(oxetan-3-yl)-4-piperidyl]-5-methyl- phenyl]-1,2,4-triazol-3-amine 209. N-[3-(difluoromethyl)-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1-(3-pyridyl)-1,2,4-triazol-3- amine 210. 211. N-[3-[4-(methoxymethyl)-1-piperidyl]-5- methyl-phenyl]-1-(2-pyridyl)-1,2,4-triazol-3-amine 212. 2-[3-(3-methyl-5-pyrrolidin-1-yl-anilino)-1,2,4- triazol-1-yl]benzonitrile 213. N-[3-fluoro-5-(4-methylpiperazin-1-yl)phenyl]- 1-phenyl-1,2,4-triazol-3-amine 214. 1-cyclopropyl-4-[3-methyl-5-[(1-phenyl-1,2,4- triazol-3-yl)amino]phenyl]piperazin-2-one 215. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(3- methyloxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 216. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)-1-piperidyl]phenyl]-1,2,4-triazol-3-amine 217. 1-(5-chloro-3-pyridyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 218. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-[3-(trifluoromethyl)phenyl]-1,2,4-triazol- 3-amine 219. N-[3-methyl-5-[(1S,4S)-2-(oxetan-3-yl)-2,5- diazabicyclo[2.2.1]heptan-5-yl]phenyl]-1-phenyl-1,2,4- triazol-3-amine 220. 1-(3-chloro-5-fluoro-phenyl)-N-[3-methyl-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 221. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[1- (oxetan-3-yl)-4-piperidyl]phenyl]-1,2,4-triazol-3-amine 222. 223. 1-(2-fluorophenyl)-N-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 224. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(4-pyridyl)-1,2,4-triazol-3-amine 225. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(2-fluorophenyl)-1,2,4-triazol-3-amine 226. 1-(2-fluoro-4-pyridyl)-N-[3-(4- methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]- 1,2,4-triazol-3-amine 227. 7-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]-5,6,8,8a-tetrahydro-1H-oxazolo[3,4- a]pyrazin-3-one 228. 1-(3,5-difluorophenyl)-N-[3-[4-(1,1- dioxothietan-3-yl)piperazin-1-yl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 229. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[1- (oxetan-3-yl)azetidin-3-yl]phenyl]-1,2,4-triazol-3- amine 230. N-[3-fluoro-5-[1-(oxetan-3-yl)pyrrolidin-3- yl]phenyl]-1-(3-fluorophenyl)-1,2,4-triazol-3-amine 231. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[4- (2,2,2-trifluoroethyl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 232. 1-(2,6-difluoro-4-pyridyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 233. 1-[2-(methoxymethyl)phenyl]-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 234. N-[3,5-bis(2,5-dihydrofuran-3-yl)phenyl]-1- phenyl-1,2,4-triazol-3-amine 235. N-[3-[3,3-difluoro-1-(oxetan-3-yl)-4-piperidyl]- 5-methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol- 3-amine 236. N-[3-[4-(oxetan-3-yl)piperazin-1-yl]-5-propyl- phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 237. N-[2,3-dimethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 238. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]aminol-5-methyl-phenyl]piperidin-4-ol 239. N-[3-methyl-5-[(3S)-1-(oxetan-3-yl)pyrrolidin- 3-yl]oxy-phenyl]-1-phenyl-1,2,4-triazol-3-amine 240. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(oxetan-3-yl)benzene-1,3-diamine 241. N-(3-fluoro-5-pyrrolidin-1-yl-phenyl)-1-[3- (trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 242. 3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1-methyl-pyrrolidin-3-ol 243. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(4- tetrahydropyran-4-ylpiperazin-1-yl)phenyl]-1,2,4- triazol-3-amine 244. 245. 246. N-[3-chloro-5-[4-(methoxymethyl)-1- piperidyl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 247. N-[3-methyl-5-(4-methylpiperazin-1- yl)phenyl]-1-phenyl-1,2,4-triazol-3-amine 248. N-[3-methyl-5-[1-(oxetan-3-y1)-3- piperidyl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 249. N3-[1-(2-fluoro-4-pyridyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-[1-(oxetan-3-yl)pyrrolidin-3-yl]benzene- 1,3-diamine 250. N-[3,5-di(tetrahydropyran-4-yl)phenyl]-1-(3- pyridyl)-1,2,4-triazol-3-amine 251. N-(3-morpholino-5-tetrahydropyran-4-yl- phenyl)-1-phenyl-1,2,4-triazol-3-amine 252. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-[3-(trifluoromethoxy)phenyl]-1,2,4- triazol-3-amine 253. N-[3-[4-(2-methoxyethyl)piperazin-1-yl]-5- methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 254. 1-(6-methoxypyrimidin-4-yl)-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 255. 1-(3-ethyl-5-fluoro-phenyl)-N-[3-methyl-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 256. N-[3-[4-(3-deuteriooxetan-3-yl)piperazin-1-yl]- 5-methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol- 3-amine 257. 1-(3-fluorophenyl)-N-[3-(4-methylpiperazin-1- yl)-5-(trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 258. 1-(3-fluorophenyl)-N-[3-methoxy-5-[4-(oxetan- 3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 259. N-[3-methyl-5-(3-methylpiperazin-1- yl)phenyl]-1-phenyl-1,2,4-triazol-3-amine 260. N-[3-methyl-5-[1-(oxetan-3-yl)pyrrolidin-3- yl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 261. N-[3-(1-cyclopropyl-4-piperidyl)-5-methyl- phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3-amine 262. 1-(5-chloro-3-pyridyl)-N-[3-methyl-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 263. 264. 1-(3,5-difluorophenyl)-N-[3-ethyl-5-[4-(3- methyloxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 265. 266. 1-[3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1-piperidyl]ethanone 267. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3- (methylamino)pyrrolidin-1-yl]phenyl]-1,2,4-triazol-3- amine 268. 1-(3,5-difluorophenyl)-N-[3-fluoro-5-[1- (oxetan-3-yl)pyrrolidin-3-yl]phenyl]-1,2,4-triazol-3- amine 269. 1-(4-fluorophenyl)-N-(3-methyl-5-pyrrolidin-1- yl-phenyl)-1,2,4-triazol-3-amine 270. N-[3-methyl-5-(oxetan-3-yl)phenyl]-1-(3- pyridyl)-1,2,4-triazol-3-amine 271. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(6-methylpyrazin-2-yl)-1,2,4-triazol-3- amine 272. 1-(3-fluorophenyl)-N-(3-methyl-5-pyrrolidin-1- yl-phenyl)-1,2,4-triazol-3-amine 273. N-[3-[1-(2,2-difluoroethyl)pyrrolidin-3-yl]-5- methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 274. N-[3-(4-ethylpiperazin-1-yl)-5-methyl-phenyl]- 1-phenyl-1,2,4-triazol-3-amine 275. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3-pyridyl)-1,2,4-triazol-3-amine 276. 1-(2,3-difluorophenyl)-N-[3-ethyl-5-[4-(oxetan- 3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 277. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(2-methoxypyrimidin-4-yl)-1,2,4- triazol-3-amine 278. N3-[1-(3,4-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-[1-(oxetan-3-yl)-4-piperidyl]benzene-1,3- diamine 279. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2-oxa-7- azaspiro[3.5]nonan-7-yl)phenyl]-1,2,4-triazol-3-amine 280. 1-[4-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]-1,4-diazepan-1-yl]ethanone 281. 3-[3-(3-methyl-5-pyrrolidin-1-yl-anilino)-1,2,4- triazol-1-yl]benzonitrile 282. (3R,4R)-4-[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5-methyl-phenyl]-1-(oxetan-3- yl)piperidin-3-ol; (3S,4S)-4-[3-[[1-(3,5- difluorophenyl)-1,2,4-triazol-3-yl]amino]-5-methyl- phenyl]-1-(oxetan-3-yl)piperidin-3-ol 283. N-[3-(3-aminoazetidin-1-yl)-5-fluoro-phenyl]- 1-(2,4-difluorophenyl)-1,2,4-triazol-3-amine 284. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- morpholinopyrrolidin-1-yl)phenyl]-1,2,4-triazol-3- amine 285. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(3-fluoro-5-isopropoxy-phenyl)-1,2,4- triazol-3-amine 286. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(2-ethoxypyrimidin-4-yl)-1,2,4-triazol- 3-amine 287. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-[3-(trifluoromethyl)phenyl]-1,2,4-triazol- 3-amine 288. N-[3-tert-butyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 289. N-[3-methyl-5-(4-tetrahydropyran-4- ylpiperazin-1-yl)phenyl]-1-phenyl-1,2,4-triazol-3- amine 290. N-[3-(4-cyclobutylpiperazin-1-yl)-5-methyl- phenyl]-1-phenyl-1,2,4-triazol-3-amine 291. 1-(5-fluoropyrimidin-4-yl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 292. N-[3-[(1S,4S)-2-cyclopropyl-2,5- diazabicyclo[2.2.1]heptan-5-yl]-5-methyl-phenyl]-1- phenyl-1,2,4-triazol-3-amine 293. 1-(3,5-difluorophenyl)-N-[3-(3-methoxy-1- piperidyl)-5-methyl-phenyl]-1,2,4-triazol-3-amine 294. N-[3-methyl-5-[1-(3-methyloxetan-3-yl)-4- piperidyl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 295. 5-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]oxazolidin-2-one 296. 297. N-[3-methyl-5-(4-methylpiperazin-1- yl)phenyl]-1-(3-pyridyl)-1,2,4-triazol-3-amine 298. 1-(3,5-difluorophenyl)-N-[3-(2,5-dihydrofuran- 3-yl)-5-morpholino-phenyl]-1,2,4-triazol-3-amine 299. 1-(3,4-difluorophenyl)-N-[3-[4- (methoxymethyl)-1-piperidyl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 300. 1-[3-[3-methyl-5-[(1-pyrazin-2-yl-1,2,4-triazol- 3-yl)amino]phenyl]-1-piperidyl]ethanone 301. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[1- (oxetan-3-yl)azetidin-3-yl]phenyl]-1,2,4-triazol-3- amine 302. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(6-methylpyrimidin-4-yl)-1,2,4-triazol- 3-amine 303. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-[4-(trifluoromethoxy)phenyl]-1,2,4- triazol-3-amine 304. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(3S)-1- (oxetan-3-yl)pyrrolidin-3-yl]oxy-phenyl]-1,2,4-triazol- 3-amine 305. N-(3-cyclopropyl-5-morpholino-phenyl)-1- phenyl-1,2,4-triazol-3-amine 306. N-[3-(2,6-dimethylmorpholin-4-yl)-5-methyl- phenyl]-1-phenyl-1,2,4-triazol-3-amine 307. N-(2-fluoro-3-methyl-5-morpholino-phenyl)-1- (2-pyridyl)-1,2,4-triazol-3-amine 308. N-[3-methyl-5-(4-piperidyl)phenyl]-1-phenyl- 1,2,4-triazol-3-amine 309. 5-methyl-N1-[1-(oxetan-3-yl)pyrrolidin-3-yl]- N3-(1-phenyl-1,2,4-triazol-3-yl)benzene-1,3-diamine 310. 1-(3,5-difluorophenyl)-N-[3-methoxy-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 311. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]-2-methyl- propane-1,3-diol 312. 1-(2,6-dimethylpyrimidin-4-yl)-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 313. 1-(3,5-difluorophenyl)-N-[3-(oxetan-3-y1)-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 314. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2-methoxypyrimidin-4-yl)-1,2,4-triazol- 3-amine 315. N-[3,5-bis(3,6-dihydro-2H-pyran-4-yl)phenyl]- 1-phenyl-1,2,4-triazol-3-amine 316. N-[3-methyl-5-(3-piperidyl)phenyl]-1-phenyl- 1,2,4-triazol-3-amine 317. 1-(3,4-difluorophenyl)-N-[3-methyl-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 318. 2-[(3R)-1-[3-fluoro-5-[3-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]anilino]-1,2,4-triazol-1- yl]phenyl]pyrrolidin-3-yl]propan-2-ol 319. 320. 1-(5-fluoro-3-pyridyl)-N-(3-methyl-5- pyrrolidin-1-yl-phenyl)-1,2,4-triazol-3-amine 321. 1-(2,4-difluorophenyl)-N-(3-fluoro-5- morpholino-phenyl)-1,2,4-triazol-3-amine 322. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-[4-(trifluoromethyl)phenyl]-1,2,4-triazol- 3-amine 323. 1-(3-fluoro-5-methyl-phenyl)-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 324. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(4- morpholino-1-piperidyl)phenyl]-1,2,4-triazol-3-amine 325. 1-(3,5-difluorophenyl)-N-[3-[2- (methoxymethyl)morpholin-4-yl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 326. N-[3-(4-isopropylpiperazin-1-yl)-5-methyl- phenyl]-1-phenyl-1,2,4-triazol-3-amine 327. 328. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(1- methyl-3-piperidyl)phenyl]-1,2,4-triazol-3-amine 329. 1-(4,6-difluoro-2-pyridyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 330. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 331. 332. 333. N-[3-methyl-5-(1-methyl-4-piperidyl)phenyl]- 1-phenyl-1,2,4-triazol-3-amine 334. 5-methyl-N1-[1-(oxetan-3-yl)-4-piperidyl]-N3- (1-phenyl-1,2,4-triazol-3-yl)benzene-1,3-diamine 335. N-(3-chloro-5-morpholino-phenyl)-1-phenyl- 1,2,4-triazol-3-amine 336. N-(3-fluoro-5-pyrrolidin-1-yl-phenyl)-1- phenyl-1,2,4-triazol-3-amine 337. N-[3-(4-cyclopropyl-1,4-diazepan-1-yl)-5- methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 338. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2-fluoro-5-methyl-phenyl)-1,2,4-triazol- 3-amine 339. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(5-fluoro-3-pyridyl)-1,2,4-triazol-3- amine 340. N-[3-(1-cyclopropyl-3-piperidyl)-5-methyl- phenyl]-1-phenyl-1,2,4-triazol-3-amine 341. N-[3-ethyl-5-(3-morpholinoazetidin-1- yl)phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 342. 5-methyl-N1-[1-(oxetan-3-yl)-4-piperidyl]-N3- [1-(3-pyridyl)-1,2,4-triazol-3-yl]benzene-1,3-diamine 343. 1-(2,4-difluorophenyl)-N-[3-fluoro-5-(1,4- oxazepan-4-yl)phenyl]-1,2,4-triazol-3-amine 344. 1-(3,5-difluorophenyl)-N-[3-methylsulfonyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 345. 346. N-(3-bromo-5-morpholino-phenyl)-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 347. 1-(2,4-difluorophenyl)-N-[3-[3- (dimethylamino)pyrrolidin-1-yl]-5-fluoro-phenyl]- 1,2,4-triazol-3-amine 348. N-[3-(4-cyclopropylpiperazin-1-yl)-5- (difluoromethyl)phenyl]-1-phenyl-1,2,4-triazol-3- amine 349. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(9- methyl-2-oxa-6,9-diazaspiro[3.5]nonan-6-yl)phenyl]- 1,2,4-triazol-3-amine 350. 2,2,2-trifluoroethyl4-[3-[[1-(3,5- difluorophenyl)-1,2,4-triazol-3-yl]amino]-5-methyl- phenyl]piperazine-1-carboxylate 351. N1-(azetidin-3-yl)-5-fluoro-N3-[1-(3- fluorophenyl)-1,2,4-triazol-3-yl]benzene-1,3-diamine 352. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]-2,2,2- trifluoro-ethanone 353. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-[6-(methoxymethyl)pyrimidin-4-yl]- 1,2,4-triazol-3-amine 354. 355. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]aminol-5-methyl-phenyl]azetidin-3-ol 356. N-(3-methyl-5-pyrrolidin-1-yl-phenyl)-1-[4- (trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 357. N-[3-morpholino-5-(trifluoromethyl)phenyl]-1- pyrazin-2-yl-1,2,4-triazol-3-amine 358. N-[3-(3,3a,4,5,7,7a-hexahydro-2H-furo[2,3- c]pyridin-6-yl)-5-methyl-phenyl]-1-phenyl-1,2,4- triazol-3-amine 359. 1-(3,5-difluorophenyl)-N-[3-isopropyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 360. 4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1-methyl-piperazin-2-one 361. 1-(3-fluorophenyl)-N-[3-methylsulfonyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 362. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 363. N-[3-methyl-5-(oxetan-3-yl)phenyl]-1-phenyl- 1,2,4-triazol-3-amine 364. 1-[6-(methoxymethyl)pyrimidin-4-yl]-N-[3- methyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 365. 366. N-[3-morpholino-5-(trifluoromethyl)phenyl]-1- phenyl-1,2,4-triazol-3-amine 367. 368. tert-butyl 4-[3-ethyl-5-[(1-pyrazin-2-yl-1,2,4- triazol-3-yl)amino]phenyl]piperazine-1-carboxylate 369. N-[3-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a- hexahydropyrrolo[2,3-c]pyrrol-5-yl]-5-methyl-phenyl]- 1-phenyl-1,2,4-triazol-3-amine 370. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]ethanone 371. N-(3-fluoro-5-morpholino-phenyl)-1-(5-fluoro- 3-pyridyl)-1,2,4-triazol-3-amine 372. N-(3-methyl-5-pyrrolidin-1-yl-phenyl)-1-(p- tolyl)-1,2,4-triazol-3-amine 373. 1-[3-fluoro-5-[2- methoxyethyl(methyl)amino]phenyl]-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 374. 1-(3,5-difluorophenyl)-N-(3-methyl-5- morpholino-phenyl)-1,2,4-triazol-3-amine 375. 1-(3-fluorophenyl)-N-[3-methyl-5-[4-(3- methyloxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 376. N-[3-tert-butyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-phenyl-1,2,4-triazol-3-amine 377. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(6-methoxypyrimidin-4-yl)-1,2,4- triazol-3-amine 378. 379. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- pyrazol-1-ylazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 380. N-(3-chloro-5-pyrrolidin-1-yl-phenyl)-1- phenyl-1,2,4-triazol-3-amine 381. N-[3-methyl-5-(4-methylpiperazin-1- yl)phenyl]-1-pyrimidin-5-yl-1,2,4-triazol-3-amine 382. 1-(3-fluorophenyl)-N-[3-methyl-5-[1-(oxetan-3- yl)pyrrolidin-3-yl]phenyl]-1,2,4-triazol-3-amine 383. 1-(2,5-difluorophenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)-1-piperidyl]phenyl]-1,2,4-triazol-3-amine 384. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[[1- (oxetan-3-yl)-4-piperidyl]oxy]phenyl]-1,2,4-triazol-3- amine 385. N-[3-[4-(methoxymethyl)-1-piperidyl]-5- methyl-phenyl]-1-(4-pyridyl)-1,2,4-triazol-3-amine 386. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 387. 1-(5-fluoro-3-pyridyl)-N-[3-methyl-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 388. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(3-fluoro-5-methoxy-phenyl)-1,2,4- triazol-3-amine 389. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3- amine 390. 1-[3-[[ethyl(methyl)amino]methyl]-5-fluoro- phenyl]-N-[3-methyl-5-(4-methylpiperazin-1- yl)phenyl]-1,2,4-triazol-3-amine 391. N-[3-methyl-5-[(3R)-1-(oxetan-3-yl)pyrrolidin- 3-yl]oxy-phenyl]-1-phenyl-1,2,4-triazol-3-amine 392. N-[3-(difluoromethyl)-5-morpholino-phenyl]-1- phenyl-1,2,4-triazol-3-amine 393. 394. N-(3-fluoro-5-morpholino-phenyl)-1-(4- fluorophenyl)-1,2,4-triazol-3-amine 395. 1-(3-fluoro-5-methoxy-phenyl)-N-[3-methyl-5- (4-methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 396. 1-(3,5-difluorophenyl)-N-[3-[4-(oxetan-3- yl)piperazin-1-yl]-5-propyl-phenyl]-1,2,4-triazol-3- amine 397. 1-(3-chlorophenyl)-N-[3-methyl-5-[4-(oxetan- 3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 398. N-[3-methyl-5-[4-(2,2,2- trifluoroethyl)piperazin-1-yl]phenyl]-1-phenyl-1,2,4- triazol-3-amine 399. N-[3-methyl-5-(4-methylpiperazin-1- yl)phenyl]-1-pyridazin-4-yl-1,2,4-triazol-3-amine 400. 1-(3-chloro-5-fluoro-phenyl)-N-[3-cyclopropyl- 5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 401. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(6-methylpyrazin-2-yl)-1,2,4-triazol-3- amine 402. 1-[4-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]anilino]-1-piperidyl]ethanone 403. 1-(2-fluoro-4-pyridyl)-N-(3-methyl-5- morpholino-phenyl)-1,2,4-triazol-3-amine 404. N-[3-methyl-5-(oxetan-3-yl)phenyl]-1-(2- pyridyl)-1,2,4-triazol-3-amine 405. 406. 1-(3-fluorophenyl)-N-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 407. 408. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[1- (oxetan-3-yl)-3-piperidyl]phenyl]-1,2,4-triazol-3-amine 409. 1-(4-fluorophenyl)-N-[3-methyl-5-(oxetan-3- yl)phenyl]-1,2,4-triazol-3-amine 410. N-[3-methyl-5-[[1-(oxetan-3-yl)-4- piperidyl]oxy]phenyl]-1-phenyl-1,2,4-triazol-3-amine 411. 1-(3-fluorophenyl)-N-[3-methyl-5-[1-(oxetan-3- yl)-3-piperidyl]phenyl]-1,2,4-triazol-3-amine 412. 1-(3,4-difluorophenyl)-N-[3-(4- methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]- 1,2,4-triazol-3-amine 413. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2,4,5-trifluorophenyl)-1,2,4-triazol-3- amine 414. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(o-tolyl)-1,2,4-triazol-3-amine 415. 1-(3-fluoro-5-isopropoxy-phenyl)-N-[3-methyl- 5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 416. 3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1-(oxetan-3-yl)pyrrolidin- 3-ol 417. 1-(2,5-difluorophenyl)-N-[3-ethyl-5-[4-(oxetan- 3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 418. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2-methylpyrimidin-4-yl)-1,2,4-triazol-3- amine 419. N-[3-methyl-5-(2,4,5-trimethylpiperazin-1- yl)phenyl]-1-phenyl-1,2,4-triazol-3-amine 420. N-[3-(4-cyclopropylpiperazin-1-yl)-5-methyl- phenyl]-1-(6-methylpyrazin-2-yl)-1,2,4-triazol-3-amine 421. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4- (2,2,2-trifluoroethyl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 422. methyl4-[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5-methyl-phenyl]piperazine-1- carboxylate 423. N-[3-methyl-5-[(3R,5S)-3,4,5- trimethylpiperazin-1-yl]phenyl]-1-phenyl-1,2,4-triazol- 3-amine 424. 1-(3-fluoro-5-methyl-pheny1)-N-[3-methyl-5- (4-methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 425. 1-(3,5-difluorophenyl)-N-[2,3-dimethyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 426. N-(3-chioro-5-morpholino-phenyl)-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 427. 1-(5-fluoro-3-pyridyl)-N-(3-methyl-5- morpholino-phenyl)-1,2,4-triazol-3-amine 428. 1-(2-chlorophenyl)-N-[3-methyl-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 429. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- piperidyl)phenyl]-1,2,4-triazol-3-amine 430. 431. N-[3-methyl-5-[4-[(3-methyloxetan-3- yl)methyl]piperazin-1-yl]phenyl]-1-phenyl-1,2,4- triazol-3-amine 432. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3-methoxyphenyl)-1,2,4-triazol-3-amine 433. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[[1- (oxetan-3-yl)-4-piperidyl]oxy]phenyl]-1,2,4-triazol-3- amine 434. N-[3-methyl-5-(4-tetrahydrofuran-3- ylpiperazin-1-yl)phenyl]-1-phenyl-1,2,4-triazol-3- amine 435. 1-(3-fluorophenyl)-N-(3-fluoro-5-pyrrolidin-1- yl-phenyl)-1,2,4-triazol-3-amine 436. N-[3-methyl-5-[4-(3-methyloxetan-3- yl)piperazin-1-yl]phenyl]-1-phenyl-1,2,4-triazol-3- amine 437. 1-(2,5-difluorophenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 438. 4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperidin-3-ol 439. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3-methylsulfanylphenyl)-1,2,4-triazol-3- amine 440. 1-(3,4-difluorophenyl)-N-(3-fluoro-5- morpholino-phenyl)-1,2,4-triazol-3-amine 441. N-(3-fluoro-5-pyrrolidin-1-yl-phenyl)-1-[4- (trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 442. 3-[3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1- piperidyl]cyclobutanecarboxylic acid 443. 1-[3-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]pyrrolidin-1-yl]ethanone 444. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2-oxa-7- azaspiro[3.4]octan-7-yl)phenyl]-1,2,4-triazol-3-amine 445. 1-(2,3-difluorophenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 446. 1-(2-chlorophenyl)-N-[3-methyl-5-[4-(oxetan- 3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 447. 1-(5-fluoro-3-pyridyl)-N-[3-methyl-5-(oxetan- 3-yl)phenyl]-1,2,4-triazol-3-amine 448. N1-cyclopropyl-N3-[1-(3,5-difluorophenyl)- 1,2,4-triazol-3-yl]-5-methyl-benzene-1,3-diamine 449. 1-[3-[3-methyl-5-[(1-pyrimidin-4-yl-1,2,4- triazol-3-yl)amino]phenyl]-1-piperidyl]ethanone 450. 1-(2,4-difluorophenyl)-N-[3-fluoro-5-(4- methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 451. N-(2-fluoro-3-methyl-5-morpholino-phenyl)-1- (3-pyridyl)-1,2,4-triazol-3-amine 452. N-(3-fluoro-5-pyrrolidin-3-yl-phenyl)-1- phenyl-1,2,4-triazol-3-amine 453. N-[3-[4-(3,3-difluorocyclobutyl)piperazin-1- yl]-5-methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4- triazol-3-amine 454. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(2-methylpyrimidin-4-yl)-1,2,4-triazol- 3-amine 455. N-[3-[4-(2-fluorophenyl)piperazin-1-yl]-5- methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 456. 1-(3,5-difluorophenyl)-N-(3-morpholino-5- tetrahydrofuran-3-yl-phenyl)-1,2,4-triazol-3-amine 457. 458. cyclopropyl-[4-[3-[[1-(3,5-difluorophenyl)- 1,2,4-triazol-3-yl]amino]-5-methyl-phenyl]piperazin-1- yl]methanone 459. 1-(3,5-difluorophenyl)-N-[3-methyl-5- [(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl]phenyl]-1,2,4-triazol-3-amine 460. 461. 2-methyl-1-[4-[3-methyl-5-[(1-phenyl-1,2,4- triazol-3-yl)amino]phenyl]piperazin-1-yl]propan-2-ol 462. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-(3-fluorophenyl)-1,2,4-triazol-3-amine 463. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3-methylsulfanylphenyl)-1,2,4-triazol-3- amine 464. N-[3-[4-(methoxymethyl)-1-piperidyl]-5- methyl-phenyl]-1-pyrimidin-4-yl-1,2,4-triazol-3-amine 465. N-[3-(2,5-dihydrofuran-3-yl)-5-morpholino- phenyl]-1-phenyl-1,2,4-triazol-3-amine 466. N-[3-(1-cyclopropyl-3-piperidyl)-5-methyl- phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3-amine 467. 1-[3-fluoro-5-[(3R)-3-fluoropyrrolidin-1- yl]phenyl]-N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1,2,4-triazol-3-amine 468. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3-fluorophenyl)-1,2,4-triazol-3-amine 469. 1-(2,5-difluorophenyl)-N-[3-methyl-5-[4-(3- methyloxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 470. N-[2,3-dimethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 471. N-[2-methoxy-3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol- 3-amine 472. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-[1-(oxetan-3-yl)pyrrolidin-3-yl]benzene- 1,3-diamine 473. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(3R)-1- (oxetan-3-yl)pyrrolidin-3-yl]phenyl]-1,2,4-triazol-3- amine 474. N-[3-methyl-5-(2,2,3,3,5,5,6,6-octadeuterio-4- methyl-piperazin-1-yl)phenyl]-1-phenyl-1,2,4-triazol- 3-amine 475. 1-(3,5-difluorophenyl)-N-[3-morpholino-5- (trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 476. 1-(2-fluoro-5-methyl-phenyl)-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 477. 478. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-[4-(trifluoromethoxy)phenyl]-1,2,4- triazol-3-amine 479. N-[3-methyl-5-[(1S,4S)-5-methyl-2,5- diazabicyclo[2.2.1]heptan-2-yl]phenyl]-1-phenyl-1,2,4- triazol-3-amine 480. [1-[3-fluoro-5-[3-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]anilino]-1,2,4-triazol-1- yl]phenyl]pyrrolidin-3-yl]methanol 481. N-[3-[4-(methoxymethyl)-1-piperidyl]-5- methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 482. N-[3-(4-cyclopropylpiperazin-1-yl)-5-methyl- phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3-amine 483. N-[3-methyl-5-[1-[(3-methyloxetan-3- yl)methyl]-4-piperidyl]phenyl]-1-phenyl-1,2,4-triazol- 3-amine 484. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2,3,5-trifluorophenyl)-1,2,4-triazol-3- amine 485. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 486. N-[3-(4-methylpiperazin-1-yl)-5- (trifluoromethyl)phenyl]-1-phenyl-1,2,4-triazol-3- amine 487. (3R)-3-[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5-methyl-phenyl]-1-(oxetan-3- yl)pyrrolidin-3-ol 488. 1-(6-chloro-2-pyridyl)-N-(3-methyl-5- pyrrolidin-1-yl-phenyl)-1,2,4-triazol-3-amine 489. N-[3-ethyl-5-[4-(3-methyloxetan-3- yl)piperazin-1-yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol- 3-amine 490. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[(2-methyltetrahydrofuran-2- yl)methyl]benzene-1,3-diamine 491. 1-[3-fluoro-5-[(2R)-2- (methoxymethyl)pyrrolidin-1-yl]phenyl]-N-[3-methyl- 5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 492. 493. [1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]azetidin-3-yl]methanol 494. N-[3-cyclopropyl-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1-[3-fluoro-5-(3-methoxyazetidin-1- yl)phenyl]-1,2,4-triazol-3-amine 495. 1-[2-(azepan-1-yl)-4-pyridyl]-N-[3-methyl-5- (4-methylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 496. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-(2-tetrahydrofuran-2-ylethyl)benzene- 1,3-diamine 497. 1-(2,4-difluorophenyl)-N-(3-fluoro-5- pyrrolidin-1-yl-phenyl)-1,2,4-triazol-3-amine 498. 499. 3-[3-[3-methyl-5-(4-methylpiperazin-1- yl)anilino]-1,2,4-triazol-1-yl]benzonitrile 500. N-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-phenyl]pyrrolidin-3-yl]-N- methyl-acetamide 501. 502. 503. 504. 505. [3-acetoxy-2-[4-[3-[[1-(3,5-difluorophenyl)- 1,2,4-triazol-3-yl]amino]-5-methyl-phenyl]piperazin-1- yl]-2-methyl-propyl]acetate 506. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3- (oxetan-3-yl)azetidin-1-yl]phenyl]-1,2,4-triazol-3- amine 507. N-[3-[4-(oxetan-3-yl)-1-piperidyl]-5- (trifluoromethyl)phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3- amine 508. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3-oxa-6- azaspiro[3.3]heptan-6-yl)phenyl]-1,2,4-triazol-3-amine 509. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]-2-methyl- propanoic acid 510. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- pyrrolidin-1-ylazetidin-1-yl)phenyl]-1,2,4-triazol-3- amine 511. N-[3-isopropyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrimidin-4-yl-1,2,4-triazol-3-amine 512. 513. N-[3-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)-5- (trifluoromethyl)phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3- amine 514. N-[3-[4-(oxetan-3-yl)piperazin-1-yl]-5- (trifluoromethyl)phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3- amine 515. 1-(3,5-difluorophenyl)-N-[3-[4-fluoro-1- (oxetan-3-yl)-4-piperidyl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 516. 4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1-(oxetan-3-yl)piperidin- 4-ol 517. 3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]oxazolidin-2-one 518. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-3-isopropyl-azetidin-3-ol 519. 2-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]azetidin-3-yl]propan-2-ol 520. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-(3-methoxycyclobutyl)-5-methyl-benzene-1,3- diamine 521. N-[3-methyl-5-[4-(oxetan-3-yl)-1- piperidyl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 522. 1-(3-fluorophenyl)-N-[3-methyl-5-[4-(oxetan-3- yl)-1-piperidyl]phenyl]-1,2,4-triazol-3-amine 523. 1-(3-fluorophenyl)-N-[3-isopropyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 524. 525. 526. 527. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(6-oxa-3- azabicyclo[3.1.1]heptan-3-yl)phenyl]-1,2,4-triazol-3- amine 528. N-[3-(3,3a,4,6,7,7a-hexahydro-2H-furo[3,2- c]pyridin-5-yl)-5-methyl-phenyl]-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 529. 530. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-[(3S)- tetrahydrofuran-3-yl]piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 531. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-[(3R)- tetrahydrofuran-3-yl]piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 532. 533. tert-butyl 4-[6-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-4-methyl-2-pyridyl]piperazine-1- carboxylate 534. [2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-phenyl]piperazin-1-yl]-3- hydroxy-2-methyl-propyl]acetate 535. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrimidin-5-yl-1,2,4-triazol-3-amine 536. N-[3-isopropyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 537. 538. 539. N-[3-cyclopropyl-5-(3-morpholinoazetidin-1- yl)phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 540. 541. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2-oxa-8- azaspiro[3.5]nonan-8-yl)phenyl]-1,2,4-triazol-3-amine 542. 1-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]azetidin-3-yl]pyrrolidin-2- one 543. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(9-oxa-6- azaspiro[3.5]nonan-6-yl)phenyl]-1,2,4-triazol-3-amine 544. N-[3-ethyl-5-(3-morpholinoazetidin-1- yl)phenyl]-1-pyrimidin-5-yl-1,2,4-triazol-3-amine 545. 546. 547. 548. 549. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrimidin-5-yl-1,2,4-triazol-3-amine 550. N-[3-tert-butyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrimidin-5-yl-1,2,4-triazol-3-amine 551. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-3-methyl-azetidin-3-ol 552. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3- (trifluoromethyl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 553. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-3-ethyl-azetidin-3-ol 554. 555. 556. 557. tert-butyl 4-[6-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-4-(trifluoromethyl)-2- pyridyl]piperazine-1-carboxylate 558. 1-(2,5-difluorophenyl)-N-(3-methyl-5- piperazin-1-yl-phenyl)-1,2,4-triazol-3-amine 559. 1-(3,4-difluorophenyl)-N-[3-[4-(oxetan-3- yl)piperazin-1-yl]-5-propyl-phenyl]-1,2,4-triazol-3- amine 560. 561. 2-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1,3,4,7,8,8a- hexahydropyrrolo[1,2-a]pyrazin-6-one 562. 563. 564. 565. 566. N-[3-(3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1- c][1,4]oxazin-8-yl)-5-methyl-phenyl]-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 567. 568. 569. 1-[6-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-4-methyl-2-pyridyl]-4-methyl-piperidin-4-ol 570. 571. 572. 573. N-[3,5-bis(4-tert-butylpiperazin-1-yl)phenyl]-1- (3,5-difluorophenyl)-1,2,4-triazol-3-amine 574. N-[3,5-bis[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3- amine 575. N-[3-methyl-5-(2-morpholinoethoxy)phenyl]-1- [3-(trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 576. 577. 1-(3,4-difluorophenyl)-N-[3-ethyl-5-[4-(3- methyloxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 578. 579. 580. 581. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)morpholin-2-yl]phenyl]-1,2,4-triazol-3- amine 582. [4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]- morpholino-methanone 583. N-[3-methyl-5-[[4-(oxetan-3-yl)piperazin-1- yl]methyl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 584. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-N-[(1S)-2-methoxy-1- methyl-ethyl]azetidine-3-carboxamide 585. N-[3-methyl-5-[4-(3-methyloxetan-3- yl)piperazin-1-yl]phenyl]-1-(3-pyridyl)-1,2,4-triazol-3- amine 586. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-(4- oxa-7-azaspiro[2.5]octan-7-yl)azetidin-1-yl]phenyl]- 1,2,4-triazol-3-amine 587. 1-(3,5-difluorophenyl)-N-[2-fluoro-3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 588. 5-methyl-N1-(5-methylthiazol-2-yl)-N3-(1- phenyl-1,2,4-triazol-3-yl)benzene-1,3-diamine 589. [1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-4-piperidyl]-morpholino- methanone 590. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[[1- (oxetan-3-yl)-3-piperidyl]oxy]phenyl]-1,2,4-triazol-3- amine 591. 1-(3,5-difluorophenyl)-N-[3-isopropoxy-2- methyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 592. 3-[4-(oxetan-3-yl)piperazin-1-yl]-5-[(1-phenyl- 1,2,4-triazol-3-yl)amino]benzonitrile 593. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(2- morpholinoethyl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 594. N-[3-fluoro-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3-fluorophenyl)-1,2,4-triazol-3-amine 595. 1-[3-(difluoromethyl)phenyl]-N-[3-methyl-5- (3-morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3- amine 596. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[[4- (oxetan-3-yl)piperazin-1-yl]methyl]phenyl]-1,2,4- triazol-3-amine 597. 1-(3-chloro-4-fluoro-phenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 598. N-[3-fluoro-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 599. 600. 601. 602. 1-(3,5-difluorophenyl)-N-[3-[3-(2,2- dimethylmorpholin-4-yl)azetidin-1-yl]-5-methyl- phenyl]-1,2,4-triazol-3-amine 603. (5S)-5-methyl-5-[3-methyl-5-[(1-pyrazin-2-yl- 1,2,4-triazol-3-yl)amino]phenyl]oxazolidin-2-one 604. N1-(1-ethyl-1,2,4-triazol-3-yl)-5-methyl-N3-(1- phenyl-1,2,4-triazol-3-yl)benzene-1,3-diamine 605. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(1- methylpyrazol-3-yl)methoxy]phenyl]-1,2,4-triazol-3- amine 606. 1-(4-fluorophenyl)-N-[3-methyl-5-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 607. 608. 3-morpholino-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]benzonitrile 609. N-[3-methyl-5-[4-(oxetan-3-yl)-1,4-diazepan-1- yl]phenyl]-1-(2-pyridyl)-1,2,4-triazol-3-amine 610. 611. (5S)-5-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-phenyl]-3,5-dimethyl- oxazolidin-2-one 612. 613. 5-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-3,5-dimethyl-oxazolidin- 2-one 614. 615. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[(3- methyloxetan-3-yl)methoxy]phenyl]-1,2,4-triazol-3- amine 616. 617. 1-(3,5-difluorophenyl)-N-[3-[3-(4-fluoro-1- piperidyl)azetidin-1-yl]-5-methyl-phenyl]-1,2,4-triazol- 3-amine 618. 1-(3,5-difluorophenyl)-N-[3-[3-[(2R,6S)-2,6- dimethylmorpholin-4-yl]azetidin-1-yl]-5-methyl- phenyl]-1,2,4-triazol-3-amine 619. 620. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[[1- (oxetan-3-yl)-3-piperidyl]oxy]phenyl]-1,2,4-triazol-3- amine 621. 622. 1-(4-fluorophenyl)-N-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 623. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(2S)-4- (oxetan-3-yl)morpholin-2-yl]phenyl]-1,2,4-triazol-3- amine 624. 1-(3-fluoro-4-methoxy-phenyl)-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 625. 626. 1-[4-[3-[[1-(3,4-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenoxy]-1-piperidyl]ethanone 627. 1-(3,4-difluorophenyl)-N-[3-methyl-5- (tetrahydropyran-4-ylmethoxy)phenyl]-1,2,4-triazol-3- amine 628. 1-(3,5-difluorophenyl)-N-[3-methyl-5- [(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5- yl]phenyl]-1,2,4-triazol-3-amine 629. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[5- methyl-4-(oxetan-3-yl)morpholin-2-yl]phenyl]-1,2,4- triazol-3-amine 630. 1-(3,5-difluorophenyl)-N-[2-fluoro-5-methyl-3- [[4-(oxetan-3-yl)piperazin-1-yl]methyl]phenyl]-1,2,4- triazol-3-amine 631. 632. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[[(3S)-1- (oxetan-3-yl)-3-piperidyl]oxy]phenyl]-1,2,4-triazol-3- amine 633. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[4-(3- methyloxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 634. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-(1- piperidyl)azetidin-1-yl]phenyl]-1,2,4-triazol-3-amine 635. 1-(3,5-difluorophenyl)-N-(3-methyl-5- tetrahydropyran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 636. 637. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)-1,4-diazepan-1-yl]phenyl]-1,2,4-triazol- 3-amine 638. 1-(3,4-difluorophenyl)-N-(3-methyl-5- tetrahydropyran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 639. 640. N-[3-[(3,3-difluorocyclobutyl)methoxy]-5- methyl-phenyl]-1-(3,4-difluorophenyl)-1,2,4-triazol-3- amine 641. 1-(3,5-difluorophenyl)-N-[3-isopropoxy-2- methyl-5-(3-morpholinoazetidin-1-yl)phenyl]-1,2,4- triazol-3-amine 642. N-[3-fluoro-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2-pyridyl)-1,2,4-triazol-3-amine 643. 5-methyl-N3-(1-phenyl-1,2,4-triazol-3-yl)-N1- thiazol-2-yl-benzene-1,3-diamine 644. N-[3-methyl-5-(2-pyrazol-1-ylethoxy)phenyl]- 1-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 645. 646. 1-(3,5-difluoro-4-methoxy-phenyl)-N-[3- methyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 647. 1-(4-fluoro-3-methyl-phenyl)-N-[3-fluoro-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 648. 1-(3,5-difluorophenyl)-N-[3-methyl-5- (tetrahydrofuran-3-ylmethoxy)phenyl]-1,2,4-triazol-3- amine 649. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-(3-morpholinocyclobutyl)benzene-1,3- diamine 650. 651. N-[3-methyl-5-(3-morpholinoazetidin-1- yl)phenyl]-1-[3-(trifluoromethyl)phenyl]-1,2,4-triazol- 3-amine 652. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-(5- oxa-2-azabicyclo[4.1.0]heptan-2-yl)azetidin-1- yl]phenyl]-1,2,4-triazol-3-amine 653. 1-(3,5-difluorophenyl)-N-[3-isopropoxy-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 654. 655. (5R)-5-[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5-methyl-pheny1]-5-methyl- oxazolidin-2-one 656. 3-[[1-(3,4-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-[4-(oxetan-3-yl)piperazin-1-yl]benzonitrile 657. N-[3,5-bis(4-methylpiperazin-1-yl)phenyl]-1- (3,5-difluorophenyl)-1,2,4-triazol-3-amine 658. 5-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-5-methyl-oxazolidin-2- one 659. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[3-(1,4- oxazepan-4-yl)azetidin-1-yl]phenyl]-1,2,4-triazol-3- amine 660. 661. 1-(3,5-difluorophenyl)-N-[3-[3-(1,1-dioxo-1,4- thiazinan-4-yl)azetidin-1-yl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 662. N-[3-methoxy-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-[3-(trifluoromethyl)phenyl]-1,2,4-triazol- 3-amine 663. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[6- methyl-4-(oxetan-3-yl)morpholin-2-yl]phenyl]-1,2,4- triazol-3-amine 664. 665. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[[(3R)-1- (oxetan-3-yl)-3-piperidyl]oxy]phenyl]-1,2,4-triazol-3- amine 666. 3-morpholino-5-[(1-pyrazin-2-yl-1,2,4-triazol- 3-yl)amino]benzonitrile 667. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(2S)-2- methyl-4-(oxetan-3-yl)morpholin-2-yl]phenyl]-1,2,4- triazol-3-amine 668. 3-[[1-(3,4-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-morpholino-benzonitrile 669. N3-(1-isopropylpyrazol-3-yl)-5-methyl-N1-(1- phenyl-1,2,4-triazol-3-yl)benzene-1,3-diamine 670. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-[(3R)- 3-methylmorpholin-4-yl]azetidin-1-yl]phenyl]-1,2,4- triazol-3-amine 671. N-[3-methyl-5-[(3-methyloxetan-3- yl)methoxy]phenyl]-1-[3-(trifluoromethyl)phenyl]- 1,2,4-triazol-3-amine 672. 673. 674. 675. 676. 5-methyl-N3-(1-methyl-1,2,4-triazol-3-yl)-N1- (1-phenyl-1,2,4-triazol-3-yl)benzene-1,3-diamine 677. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(3- methyloxetan-3-yl)methoxy]phenyl]-1,2,4-triazol-3- amine 678. 3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-[4-(oxetan-3-yl)piperazin-1-yl]benzonitrile 679. (5S)-5-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-phenyl]-5-methyl-oxazolidin-2- one 680. 681. 5-methyl-N1,N3-bis(1-phenyl-1,2,4-triazol-3- yl)benzene-1,3-diamine 682. (5R)-5-methyl-5-[3-methyl-5-[(1-pyrazin-2-yl- 1,2,4-triazol-3-yl)amino]phenyl]oxazolidin-2-one 683. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- methyl-3-morpholino-azetidin-1-yl)phenyl]-1,2,4- triazol-3-amine 684. 685. 686. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-fluoro-N1-(oxetan-3-yl)benzene-1,3-diamine 687. 4-[3-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]anilino]-1,2,4-triazol-1-yl]benzonitrile 688. N-[3-(2,6-diazaspiro[3.3]heptan-2-yl)-2-fluoro- 5-methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol- 3-amine 689. 690. [1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]azetidin-3-yl]-morpholino- methanone 691. 1-(3,5-difluorophenyl)-N-[2-fluoro-5-methyl-3- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 692. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(8-oxa-3- azabicyclo[3.2.1]octan-3-yl)phenyl]-1,2,4-triazol-3- amine 693. 1-[3-(difluoromethyl)phenyl]-N-[3-methoxy-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 694. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3-oxa-6- azabicyclo[3.1.1]heptan-6-yl)phenyl]-1,2,4-triazol-3- amine 695. 1-(4-fluorophenyl)-N-[3-methyl-5-[4-(3- methyloxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 696. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-[(2R)- 2-methylmorpholin-4-yl]azetidin-1-yl]phenyl]-1,2,4- triazol-3-amine 697. 1-(3,5-difluorophenyl)-N-[2,5-dimethyl-3-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 698. 1-(3,4-difluorophenyl)-N-[3-methyl-5-(2- pyrazol-1-ylethoxy)phenyl]-1,2,4-triazol-3-amine 699. 5-methyl-N3-(5-methyl-1H-pyrazol-3-yl)-N1- (1-phenyl-1,2,4-triazol-3-yl)benzene-1,3-diamine 700. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[[(3S)-1- (oxetan-3-yl)-3-piperidyl]oxy]phenyl]-1,2,4-triazol-3- amine 701. 1-(3,5-difluorophenyl)-N-[3-(3- morpholinoazetidin-1-yl)-5-[4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1,2,4-triazol-3-amine 702. 703. 1-(3,5-difluorophenyl)-N-(3-methyl-5- tetrahydrofuran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 704. N-[3-methyl-5-(3-morpholinoazetidin-1- yl)phenyl]-1-phenyl-1,2,4-triazol-3-amine 705. 5-chloro-N3-[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]-N1-(oxetan-3-yl)benzene-1,3-diamine 706. N-[3-[(3,3-difluorocyclobutyl)methoxy]-5- methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3- amine 707. 708. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[2- methyl-4-(oxetan-3-yl)morpholin-2-yl]phenyl]-1,2,4- triazol-3-amine 709. N-[3-(4-tert-butylpiperazin-1-yl)-5-methyl- phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3-amine 710. 1-(4-methoxyphenyl)-N-[3-methyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 711. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-N,N-dimethyl-azetidine-3- carboxamide 712. 713. 714. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[(1- methylpyrazol-3-yl)methoxy]phenyl]-1,2,4-triazol-3- amine 715. 1-(3-chloro-4-methyl-phenyl)-N-[3-ethyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 716. 717. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-(8- oxa-3-azabicyclo[3.2.1]octan-3-yl)azetidin-1- yl]phenyl]-1,2,4-triazol-3-amine 718. 719. 720. 1-(3,4-difluorophenyl)-N-[3-methyl-5-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 721. 1-(3-fluorophenyl)-N-[3-methyl-5-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 722. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3-oxa-8- azabicyclo[3.2.1]octan-8-yl)phenyl]-1,2,4-triazol-3- amine 723. N-[3-chloro-5-(3-morpholinoazetidin-1- yl)phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3- amine 724. 1-(3,5-difluorophenyl)-N-[3-(2,5-dioxa-8- azaspiro[3.5]nonan-8-yl)-5-methyl-phenyl]-1,2,4- triazol-3-amine 725. 1-[3-(difluoromethyl)phenyl]-N-[3-methyl-5- (4-morpholino-1-piperidyl)phenyl]-1,2,4-triazol-3- amine 726. 727. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2-oxa-5- azabicyclo[2.2.1]heptan-5-yl)phenyl]-1,2,4-triazol-3- amine 728. 729. 730. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-[(2S)- 2-methylmorpholin-4-yl]azetidin-1-yl]phenyl]-1,2,4- triazol-3-amine 731. 732. 733. 734. 3-[3-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]anilino]-1,2,4-triazol-1-yl]benzonitrile 735. 1-(3-fluoro-4-methoxy-phenyl)-N-[3-methyl-5- (3-morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3- amine 736. 1-[3-(difluoromethyl)phenyl]-N-[3-ethyl-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 737. 3-[[1-(3-fluorophenyl)-1,2,4-triazol-3- yl]amino)-5-morpholino-benzonitrile 738. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1,5-dimethyl-N1-(2-morpholinoethyl)benzene-1,3- diamine 739. 1-(3,5-difluorophenyl)-N-[2,3-dimethyl-5-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 740. 741. 5-methyl-5-[3-methyl-5-[(1-pyrazin-2-yl-1,2,4- triazol-3-yl)amino]phenyl]oxazolidin-2-one 742. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-(6- oxa-3-azabicyclo[3.1.1]heptan-3-yl)azetidin-1- yl]phenyl]-1,2,4-triazol-3-amine 743. 1-(3,5-difluorophenyl)-N-[2-fluoro-5-methyl-3- (2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl]-1,2,4- triazol-3-amine 744. 745. N-[3-[4-(3,3-difluoroazetidin-1-yl)-1- piperidyl]-5-methyl-phenyl]-1-(3,5-difluorophenyl)- 1,2,4-triazol-3-amine 746. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-(3- oxa-8-azabicyclo[3.2.1]octan-8-yl)azetidin-1- yl]phenyl]-1,2,4-triazol-3-amine 747. 1-(3,5-difluorophenyl)-N-[3-[4-[3- (dimethylamino)propyl]piperazin-1-yl]-5-methyl- phenyl]-1,2,4-triazol-3-amine 748. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[[(3R)-1- (oxetan-3-yl)-3-piperidyl]oxy]phenyl]-1,2,4-triazol-3- amine 749. 750. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(2R)-2- methyl-4-(oxetan-3-yl)morpholin-2-yl]phenyl]-1,2,4- triazol-3-amine 751. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(2R)-4- (oxetan-3-yl)morpholin-2-yl]phenyl]-1,2,4-triazol-3- amine 752. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- morpholinocyclobutoxy)phenyl]-1,2,4-triazol-3-amine 753. N-[3-chloro-5-(3-morpholinoazetidin-1- yl)phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 754. 1-[3-fluoro-5-(trifluoromethyl)phenyl]-N-[3- methoxy-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]- 1,2,4-triazol-3-amine 755. 1-[6-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-4-methyl-2-pyridyl]piperidin-3-ol 756. 757. 1-[3-fluoro-5-(trifluoromethyl)phenyl]-N-[3- methyl-5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 758. 759. 3-[3-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]anilino]-1,2,4-triazol-1-yl]benzonitrile 760. 761. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(3-fluoro-4-methyl-phenyl)-1,2,4-triazol- 3-amine 762. 4-[3-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]anilino]-1,2,4-triazol-1-yl]benzonitrile 763. 3-morpholino-5-[[1-(3-pyridyl)-1,2,4-triazol-3- yl]amino]benzonitrile 764. 765. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-5-methyl-N1-tetrahydrofuran-3-yl-benzene- 1,3-diamine 766. N-[3-(3-fluoroazetidin-1-yl)-5-methyl-phenyl]- 1-[3-fluoro-5-(2-methoxyethylamino)phenyl]-1,2,4- triazol-3-amine 767. 1-(3-chloro-4-methyl-phenyl)-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 768. 769. N-[3-(2-cyclopropylethynyl)-5-methyl-phenyl]- 1-(3-fluorophenyl)-1,2,4-triazol-3-amine 770. 771. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3,3,4- trimethylpiperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 772. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(4- methylpiperazin-1-yl)-1-piperidyl]phenyl]-1,2,4- triazol-3-amine 773. [1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]azetidin-3-yl]-pyrrolidin-1- yl-methanone 774. 775. 3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-fluoro-phenyl]oxetan-3-ol 776. 1-(2-fluoro-4-pyridyl)-N-[3-methyl-5-[4- (oxetan-3-yl)-1,4-diazepan-1-yl]phenyl]-1,2,4-triazol- 3-amine 777. 778. 1-(3,4-difluorophenyl)-N-(3-methyl-5- tetrahydrofuran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 779. 1-(3-fluoro-4-methyl-pheny1)-N-[3-fluoro-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 780. 1-(4-fluoro-3-methyl-phenyl)-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 781. 1-(3-fluoro-4-methoxy-phenyl)-N-[3-fluoro-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 782. 1-(3,5-difluoro-4-methoxy-phenyl)-N-[3- methyl-5-(3-morpholinoazetidin-1-yl)phenyl]-1,2,4- triazol-3-amine 783. N-[3-fluoro-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2-fluoro-4-pyridyl)-1,2,4-triazol-3-amine 784. N-[3-chloro-5-(3-morpholinoazetidin-1- yl)phenyl]-1-(3,4-difluorophenyl)-1,2,4-triazol-3- amine 785. N-[3-chloro-5-(3-morpholinoazetidin-1- yl)phenyl]-1-(2-pyridyl)-1,2,4-triazol-3-amine 786. 787. 788. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-(2- oxa-5-azabicyclo[2.2.1]heptan-5-yl)azetidin-1- yl]phenyl]-1,2,4-triazol-3-amine 789. 790. 1-(3,5-difluorophenyl)-N-[2-fluoro-5-methyl-3- (3-morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3- amine 791. 2-[[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-phenyl]azetidin-3- yl]amino]ethanol 792. N1-[1-(3,4-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-(3-morpholinocyclobutyl)benzene-1,3- diamine 793. 3-[[1-(3-fluorophenyl)-1,2,4-triazol-3- yl]amino]-5-[4-(oxetan-3-yl)piperazin-1-yl]benzonitrile 794. 1-[3-(difluoromethyl)phenyl]-N-[3-fluoro-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 795. 796. (5R)-5-[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5-methyl-phenyl]-3,5-dimethyl- oxazolidin-2-one 797. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(3-morpholinocyclobutyl)benzene-1,3- diamine 798. N-[3-(2-cyclopropylethynyl)-5-methyl-phenyl]- 1-(3,5-difluorophenyl)-1,2,4-triazol-3-amine 799. N3-[1-(3,4-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(3-morpholinocyclobutyl)benzene-1,3- diamine 800. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-[(3S)- 3-methylmorpholin-4-yl]azetidin-1-yl]phenyl]-1,2,4- triazol-3-amine 801. 802. N-[3-ethyl-5-[4-(3-methyloxetan-3- yl)piperazin-1-yl]phenyl]-1-(4-fluorophenyl)-1,2,4- triazol-3-amine 803. 1-(3,4-difluorophenyl)-N-[3-fluoro-5-[4- (oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 804. N-[3-(difluoromethyl)-5-(3- morpholinoazetidin-1-yl)phenyl]-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 805. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenoxy]-1-piperidyl]ethanone 806. 807. 808. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-(1,4- oxazepan-4-yl)azetidin-1-yl]phenyl]-1,2,4-triazol-3- amine 809. 1-(3,5-difluorophenyl)-N-[3-[4-[2- (dimethylamino)ethyl]piperazin-1-yl]-5-methyl- phenyl]-1,2,4-triazol-3-amine 810. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-5-methyl-N1-tetrahydropyran-4-yl-benzene- 1,3-diamine 811. N-[3-isopropoxy-2-methyl-5-(3- morpholinoazetidin-1-yl)phenyl]-1-(2-pyridyl)-1,2,4- triazol-3-amine 812. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2- morpholinoethoxy)phenyl]-1,2,4-triazol-3-amine 813. N-[3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-phenoxy]cyclobuty1]acetamide 814. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2-oxa-8- azaspirof4.5]decan-8-yl)phenyl]-1,2,4-triazol-3-amine 815. [1-[6-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-4-methyl-2-pyridyl]-3-piperidyl]methanol 816. 1-(3,5-difluorophenyl)-N-[3-[3-(2- methoxyethylamino)azetidin-1-yl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 817. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-N,N-diethyl-azetidine-3- carboxamide 818. N-[3-methyl-5-[4-(oxetan-3-yl)-1,4-diazepan-1- yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 819. N-[3-chloro-5-(3-morpholinoazetidin-1- yl)phenyl]-1-(2-fluoro-4-pyridyl)-1,2,4-triazol-3-amine 820. 1-(3,5-difluorophenyl)-N-[2,5-dimethyl-3-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 821. 1-[6-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-4-methyl-2-pyridyl]azetidine-3-carbonitrile 822. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(1S,4S)- 2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]-1,2,4- triazol-3-amine 823. 824. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-N-(2-methoxyethyl)-N- methyl-azetidine-3-carboxamide 825. N-[3-methyl-5-[3-(1,4-oxazepan-4-yl)azetidin- 1-yl]phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3-amine 826. N1-[1-(3,4-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-(3-morpholinocyclobutyl)benzene-1,3- diamine 827. N-[3-chloro-5-(3-morpholinoazetidin-1- yl)phenyl]-1-(3-fluorophenyl)-1,2,4-triazol-3-amine 828. 5-methyl-N3-(1-methylpyrazol-3-yl)-N1-(1- phenyl-1,2,4-triazol-3-yl)benzene-1,3-diamine 829. N-[3-ethyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(4-fluoro-3-methyl-phenyl)-1,2,4-triazol- 3-amine 830. 1-(3,5-difluorophenyl)-N-[3-isopropoxy-5-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 831. N-[3-[(8aS)-7,7-difluoro-1,3,4,6,8,8a- hexahydropyrrolo[1,2-a]pyrazin-2-yl]-5-methyl- phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3-amine 832. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2- pyrazol-1-ylethoxy)phenyl]-1,2,4-triazol-3-amine 833. 1-[3-(difluoromethyl)phenyl]-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 834. 1-(3,4-difluorophenyl)-N-[2-fluoro-5-methyl-3- [[4-(oxetan-3-yl)piperazin-1-yl]methyl]phenyl]-1,2,4- triazol-3-amine 835. 3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-morpholino-benzonitrile 836. 1-(3-fluoro-4-methyl-phenyl)-N-[3-methyl-5- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 837. 838. 5-methyl-N1-oxazol-2-yl-N3-(1-phenyl-1,2,4- triazol-3-yl)benzene-1,3-diamine 839. 840. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[[4- (oxetan-3-yl)piperazin-1-yl]methyl]phenyl]-1,2,4- triazol-3-amine 841. 1-(4-methoxyphenyl)-N-[3-methyl-5-(3- morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3-amine 842. 3-[4-(oxetan-3-yl)piperazin-1-yl]-5-[[1-(3- pyridyl)-1,2,4-triazol-3-yl]amino]benzonitrile 843. 844. 1-(3,4-difluorophenyl)-N-[3-methyl-5-(2- morpholinoethoxy)phenyl]-1,2,4-triazol-3-amine 845. 3,5-dimethyl-5-[3-methyl-5-[(1-pyrazin-2-yl- 1,2,4-triazol-3-yl)amino]phenyl]oxazolidin-2-one 846. 847. 848. 849. 1-(3,5-difluorophenyl)-N-[3-[4-(3- methoxypropyl)piperazin-1-yl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 850. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(1-oxa-8- azaspiro[4.5]decan-8-yl)phenyl]-1,2,4-triazol-3-amine 851. 2-[3-fluoro-5-[3-[3-(3-fluoroazetidin-1-yl)-5- methyl-anilino]-1,2,4-triazol-1-yl]anilino]ethanol 852. 853. N-[3-methyl-5-(4-morpholino-1- piperidyl)phenyl]-1-[3-(trifluoromethyl)phenyl]-1,2,4- triazol-3-amine 854. 855. 1-(3,5-difluorophenyl)-N-(2-fluoro-5-methyl-3- tetrahydrofuran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 856. 1-(3,5-difluorophenyl)-N-[3-[3-[(2R,6R)-2,6- dimethylmorpholin-4-yl]azetidin-1-yl]-5-methyl- phenyl]-1,2,4-triazol-3-amine 857. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-(2-morpholinoethyl)benzene-1,3-diamine 858. 859. 860. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-(3-morpholinocyclobutyl)benzene-1,3- diamine 861. N-[3-isopropoxy-2-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1-(2-pyridyl)-1,2,4-triazol-3- amine 862. N-[3-chloro-5-(3-morpholinoazetidin-1- yl)phenyl]-1-pyrimidin-4-yl-1,2,4-triazol-3-amine 863. [3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-[4-(oxetan-3-yl)piperazin- 1-yl]methanone 864. 1-(3,4-difluorophenyl)-N-[3-methyl-5- (tetrahydrofuran-3-ylmethoxy)phenyl]-1,2,4-triazol-3- amine 865. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3- (morpholinomethyl)azetidin-1-yl]phenyl]-1,2,4-triazol- 3-amine 866. 867. N-[3,5-bis(3-morpholinoazetidin-1-yl)phenyl]- 1-(3,5-difluorophenyl)-1,2,4-triazol-3-amine 868. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-5-methyl-N1-(3-methyloxetan-3-yl)benzene- 1,3-diamine 869. 1-(3,5-difluorophenyl)-N-[2-fluoro-3-methyl-5- (3-morpholinoazetidin-1-yl)phenyl]-1,2,4-triazol-3- amine 870. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- methyl-4-morpholino-pyrrolidin-1-yl)phenyl]-1,2,4- triazol-3-amine 871. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[2-(3-ethylmorpholin-4-yl)ethyl]-5-methyl- benzene-1,3-diamine 872. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[1-(2-fluoroethyl)-3-piperidyl]-5-methyl-benzene- 1,3-diamine 873. 2-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-4-piperidyl]ethanol 874. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1- yl]cyclopentanol 875. N-[3-(2,2,3,3,4,4,5,5,6,6-decadeuterio-1- piperidyl)-5-(difluoromethyl)phenyl]-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 876. 3-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-4-piperidyl]propan-1-ol 877. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1- yl]cyclohexanol 878. 1-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-4-piperidyl]piperidin-4-ol 879. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-[1-(2-morpholinoethyl)pyrrolidin-3- yl]benzene-1,3-diamine 880. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-[1-(oxetan-3-yl)azetidin-3-yl]benzene- 1,3-diamine 881. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N3-[2-(2,6-dimethylmorpholin-4-yl)propyl]-5-methyl- benzene-1,3-diamine 882. cyclopropyl-[2,2,3,3,5,5,6,6-octadeuterio-4-[3- [[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]amino]-5- (trifluoromethyl)phenyl]piperazin-1-yl]methanone 883. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(3-pyrrolidin-1-yltetrahydropyran-4- yl)benzene-1,3-diamine 884. 1-(3,5-difluorophenyl)-N-[3-methyl-5- [2,2,3,3,5,5,6,6-octadeuterio-4-(1,4-dioxan-2- ylmethyl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 885. N-(2-fluoro-5-methyl-3-tetrahydrofuran-3- yloxy-phenyl)-1-(3-fluorophenyl)-1,2,4-triazol-3-amine 886. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-anilino]-N,N-dimethyl- cyclobutanecarboxamide 887. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2- tetrahydrofuran-2-ylmorpholin-4-yl)phenyl]-1,2,4- triazol-3-amine 888. N-[3-(1,4-diazabicyclo[3.2.1]octan-4-yl)-5- methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3- amine 889. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- tetrahydrofuran-3-ylazetidin-1-yl)phenyl]-1,2,4-triazol- 3-amine 890. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-[1-(tetrahydrofuran-2-ylmethyl)-4- piperidyl]benzene-1,3-diamine 891. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(1- methyl-3-piperidyl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 892. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[(4-ethylmorpholin-2-yl)methyl]-5-methyl- benzene-1,3-diamine 893. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[1-(2-methoxyethyl)pyrrolidin-3-yl]-5-methyl- benzene-1,3-diamine 894. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[(2- morpholinocyclopentyl)methyl]benzene-1,3-diamine 895. 1-(3,5-difluorophenyl)-N-[3-[4-(3- methoxypropyl)-1,4-diazepan-1-yl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 896. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-(1-ethyl-3-piperidyl)-5-methyl-benzene-1,3- diamine 897. N-[3-[4-(3-deuteriooxetan-3-yl)piperazin-1-yl]- 5-methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 898. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-(3,3,3-trifluoro-2-morpholino- propyl)benzene-1,3-diamine 899. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]-3-ethoxy- propan-2-ol 900. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(1-oxa-7- azaspiro[3.4]octan-7-yl)phenyl]-1,2,4-triazol-3-amine 901. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-2-methyl-piperazin-1- yl]ethanol 902. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N3-[(4-isobutylmorpholin-2-yl)methyl]-5-methyl- benzene-1,3-diamine 903. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]butan-1-ol 904. 1-cyclopentyl-4-[3-[[1-(3,5-difluorophenyl)- 1,2,4-triazol-3-yl]amino]-5-methyl-phenyl]piperazin-2- one 905. 1-(3,5-difluorophenyl)-N-[3-(3,7-dioxa-10- azaspiro[5.6]dodecan-10-yl)-5-methyl-phenyl]-1,2,4- triazol-3-amine 906. N-(2-fluoro-5-methyl-3-tetrahydrofuran-3- yloxy-phenyl)-1-phenyl-1,2,4-triazol-3-amine 907. N-[2-fluoro-5-methyl-3-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1-(2-pyridyl)-1,2,4-triazol-3- amine 908. 1-(3,5-difluorophenyl)-N-[2,3-dimethyl-5- (oxetan-3-ylmethoxy)phenyl]-1,2,4-triazol-3-amine 909. 1-cyclobutyl-3-[3-methyl-5-[(1-phenyl-1,2,4- triazol-3-yl)amino]phenyl]urea 910. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- morpholino-1-piperidyl)phenyl]-1,2,4-triazol-3-amine 911. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(2-morpholinocyclopentyl)benzene-1,3- diamine 912. N-(2-fluoro-5-methyl-3-tetrahydrofuran-3- yloxy-phenyl)-1-(3-fluorophenyl)-1,2,4-triazol-3-amine 913. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4- (tetrahydrofuran-2-ylmethyl)piperazin-1-yl]phenyl]- 1,2,4-triazol-3-amine 914. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-5-methyl-N1-(oxetan-3-yl)benzene-1,3- diamine 915. 1-(3,5-difluorophenyl)-N-[3-methyl-5- (2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl)phenyl]- 1,2,4-triazol-3-amine 916. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[2-(2-ethylmorpholin-4-yl)ethyl]-5-methyl- benzene-1,3-diamine 917. N1-(2-cyclopropyltetrahydropyran-4-yl)-N3-[1- (3,5-difluorophenyl)-1,2,4-triazol-3-yl]-5-methyl- benzene-1,3-diamine 918. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(2S)-2- (morpholinomethyl)pyrrolidin-1-yl]phenyl]-1,2,4- triazol-3-amine 919. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2- methyl-4-morpholino-pyrrolidin-1-yl)phenyl]-1,2,4- triazol-3-amine 920. 2-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]azetidin-3-yl]acetonitrile 921. 2-[2,2,3,3,5,5,6,6-octadeuterio-4-[3-[[1-(3,5- difluorophenyl)-1,2,4-triazol-3-yl]amino]-5-methyl- phenyl]piperazin-1-yl]ethanol 922. [3-acetoxy-2-[4-[3-[[1-(3,5-difluorophenyl)- 1,2,4-triazol-3-yl]amino]-2-fluoro-5-methyl- phenyl]piperazin-1-yl]propyl]acetate 923. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(7-oxa-1- azaspiro[3.5]nonan-1-yl)phenyl]-1,2,4-triazol-3-amine 924. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3- methyl-4-(1-methyl-4-piperidyl)piperazin-1- yl]phenyl]-1,2,4-triazol-3-amine 925. 1-(3,5-difluorophenyl)-N-[3-methyl-5- (2,2,3,3,5,5,6,6-octadeuterio-4-tetrahydropyran-3-yl- piperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 926. 1-(3,5-difluorophenyl)-N-[3-[2- (isopropoxymethyl)morpholin-4-yl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 927. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[2-(2-methylmorpholin-4- yl)ethyl]benzene-1,3-diamine 928. N-[3-[4-(1-deuterio-1-methyl-ethyl)piperazin-1- yl]-5-methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 929. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[1-(2-methoxyethyl)-4-piperidyl]-5-methyl- benzene-1,3-diamine 930. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(1-methyl-2-morpholino-ethyl)benzene- 1,3-diamine 931. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N3-(1,4-dioxan-2-ylmethyl)-5-methyl-benzene-1,3- diamine 932. 1-(3,5-difluorophenyl)-N-[3-[4-[2- (dimethylamino)ethoxy]-1-piperidyl]-5-methyl- phenyl]-1,2,4-triazol-3-amine 933. 4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-anilino]-1-(2- methoxyethyl)pyrrolidin-2-one 934. 1-(3,5-difluorophenyl)-N-[3-methyl-5- [2,2,3,3,5,5,6,6-octadeuterio-4-(2,2- difluoroethyl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 935. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4- (tetrahydrofuran-3-ylmethyl)piperazin-1-yl]phenyl]- 1,2,4-triazol-3-amine 936. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N3-[[1-(methoxymethyl)cyclopropy1]methyl]-5- methyl-benzene-1,3-diamine 937. 1-[[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-anilino]methyl]-N,N-dimethyl- cyclopentanecarboxamide 938. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(2-morpholinocyclohexyl)benzene-1,3- diamine 939. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[2-(1-oxo-1,4-thiazinan-4- yl)ethyl]benzene-1,3-diamine 940. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-2-methyl-piperazin-1-yl]- 2-methyl-propan-2-ol 941. N3-(cyclopropylmethyl)-N1-[1-(3,5- difluorophenyl)-1,2,4-triazol-3-yl]-5-methyl-benzene- 1,3-diamine 942. N1-(1-cyclobutyl-4-piperidyl)-N3-[1-(3,5- difluorophenyl)-1,2,4-triazol-3-yl]-2-fluoro-5-methyl- benzene-1,3-diamine 943. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(2- pyrrolidin-1-ylethyl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 944. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(3- pyrrolidin-1-ylpropyl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 945. 2-[3-[[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-anilino]methyl]azetidin-1- yl]propane-1,3-diol 946. 1-(3,5-difluorophenyl)-N-[3-methyl-5- (2,2,3,3,5,5,6,6-octadeuterio-4-ethyl-piperazin-1- yl)phenyl]-1,2,4-triazol-3-amine 947. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-N,N-dimethyl-piperidin-4- amine 948. 1-(3,5-difluorophenyl)-N-[3-[4-(1,4-dioxan-2- ylmethyl)piperazin-1-yl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 949. 1-(3,5-difluorophenyl)-N-[3-[4-(2- fluoroethoxy)-1-piperidyl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 950. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[(1- morpholinocyclopropyl)methyl]benzene-1,3-diamine 951. N-(2-fluoro-5-methyl-3-tetrahydrofuran-3- yloxy-phenyl)-1-pyrazin-2-yl-1,2,4-triazol-3-amine 952. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 4-fluoro-5-methyl-N1-tetrahydrofuran-3-yl-benzene- 1,3-diamine 953. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[2-[(4- methylpiperazin-1-yl)methyl]morpholin-4-yl]phenyl]- 1,2,4-triazol-3-amine 954. N-[2-fluoro-5-methyl-3-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1-(3-fluorophenyl)-1,2,4- triazol-3-amine 955. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(1- methyl-4-piperidyl)piperazin-1-yl]phenyl]-1,2,4- triazol-3-amine 956. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]butan-2-ol 957. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]morpholin-2-yl]ethanol 958. 2,2,2-trideuterio-1-[2,2,3,3,5,5,6,6- octadeuterio-4-[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5-methyl-phenyl]piperazin-1- yl]ethanone 959. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-[1-(morpholinomethyl)propyl]benzene- 1,3-diamine 960. cyclopropyl-[2,2,3,3,5,5,6,6-octadeuterio-4-[3- [[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]amino]-5- methyl-phenyl]piperazin-1-yl]methanone 961. 1-(3,5-difluorophenyl)-N-[3-[4-(2- ethoxyethoxy)-1-piperidyl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 962. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[2-(3-ethylmorpholin-4-yl)ethyl]-2-fluoro-5- methyl-benzene-1,3-diamine 963. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]propan-1-ol 964. 2-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-4,5-dimethyl-phenoxy]-1-pyrrolidin-1-yl- ethanone 965. N-[3-(2-isopropyl-2,6-diazaspiro[3.3]heptan-6- yl)-5-methyl-phenyl]-1-(3-pyridyl)-1,2,4-triazol-3- amine 966. N-[3-(2-isopropyl-2,6-diazaspiro[3.3]heptan-6- yl)-5-methyl-phenyl]-1-pyrazin-2-yl-1,2,4-triazol-3- amine 967. N3-[(4-cyclopropylmorpholin-2-yl)methyl]-N1- [1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]-5-methyl- benzene-1,3-diamine 968. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-N1,5-dimethyl-N1-(oxetan-3-yl)benzene-1,3- diamine 969. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-(2,2-dimethyltetrahydropyran-4-yl)-5-methyl- benzene-1,3-diamine 970. 1-[3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-4,5-dimethyl-phenoxy]azetidin-1- yl]ethanone 971. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(2- tetrahydrofuran-2-ylmorpholin-4-yl)phenyl]-1,2,4- triazol-3-amine 972. 1-(3,5-difluorophenyl)-N-[3-[4-(2- ethoxyethyl)piperazin-1-yl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 973. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[2-(5-ethyl-2-methyl-morpholin-4-yl)ethyl]-5- methyl-benzene-1,3-diamine 974. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3-(4- methylpiperazin-1-yl)azetidin-1-yl]phenyl]-1,2,4- triazol-3-amine 975. 1-(3,5-difluorophenyl)-N-[3-(4-ethoxy-1- piperidyl)-5-methyl-phenyl]-1,2,4-triazol-3-amine 976. 1-(3,4-difluorophenyl)-N-[3-(2-isopropyl-2,6- diazaspiro[3.3]heptan-6-yl)-5-methyl-phenyl]-1,2,4- triazol-3-amine 977. 1-(3,4-difluorophenyl)-N-(2-fluoro-5-methyl-3- tetrahydrofuran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 978. 1-(3,5-difluorophenyl)-N-[3-methyl-5- [2,2,3,3,5,5,6,6-octadeuterio-4-(oxetan-3-yl)piperazin- 1-yl]phenyl]-1,2,4-triazol-3-amine 979. 980. N-[3-(3,4,4a,5,7,7a-hexahydro-2H-furo[3,4- b]pyridin-1-yl)-5-methyl-phenyl]-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 981. 1-(3,5-difluorophenyl)-N-[3-methyl-5- (2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)phenyl]- 1,2,4-triazol-3-amine 982. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3- (morpholinomethyl)pyrrolidin-1-yl]phenyl]-1,2,4- triazol-3-amine 983. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4- (morpholinomethyl)-1-piperidyl]phenyl]-1,2,4-triazol- 3-amine 984. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(2-morpholinobutyl)benzene-1,3-diamine 985. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[(3S)-3- pyrrolidin-1-ylpyrrolidin-1-yl]phenyl]-1,2,4-triazol-3- amine 986. N-[3-[4-[2-(diethylamino)ethyl]piperazin-1-yl]- 5-methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol- 3-amine 987. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(3- methylmorpholin-4-yl)-1-piperidyl]phenyl]-1,2,4- triazol-3-amine 988. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-2-fluoro-5-methyl-phenyl]piperazin-1- yl]propane-1,3-diol 989. 3-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]propan-1-ol 990. [4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]- tetrahydropyran-4-yl-methanone 991. N1-[1-(2,2-difluoroethyl)-4-piperidyl]-N3-[1- (3,5-difluorophenyl)-1,2,4-triazol-3-yl]-5-methyl- benzene-1,3-diamine 992. 2-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-anilino]-1-pyrrolidin-1-yl- ethanone 993. N-[3-(4-cyclobutyl-2,2,3,3,5,5,6,6-octadeuterio- piperazin-1-y1)-5-methyl-phenyl]-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 994. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]propan-2-ol 995. 1-(3,5-difluorophenyl)-N-[3-(5-ethyl-2,5- diazabicyclo[2.2.1]heptan-2-yl)-5-methyl-phenyl]- 1,2,4-triazol-3-amine 996. 1-(3,5-difluorophenyl)-N-[3-methyl-5- [2,2,3,3,5,5,6,6-octadeuterio-4-(3-deuteriooxetan-3- yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-amine 997. 1-(3,4-difluorophenyl)-N-[2-fluoro-5-methyl-3- [4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol-3- amine 998. 999. 1000. 1-(3,5-difluorophenyl)-N-[3-[4-(4- methoxybutyl)piperazin-1-yl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 1001. N-(2-fluoro-5-methyl-3-tetrahydrofuran-3- yloxy-phenyl)-1-phenyl-1,2,4-triazol-3-amine 1002. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N3-[2-(2,5-dimethylmorpholin-4-yl)ethyl]-5-methyl- benzene-1,3-diamine 1003. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[(3-methyl-4,5-dihydroisoxazol-5- yl)methyl]benzene-1,3-diamine 1004. 1-(3,5-difluorophenyl)-N-[3-[4-(2- isopropoxyethyl)piperazin-1-yl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 1005. 1-(3,5-difluorophenyl)-N-[3-(4-methoxy-1- piperidyl)-5-methyl-phenyl]-1,2,4-triazol-3-amine 1006. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-5-methyl-N1-(2- morpholinocyclopentyl)benzene-1,3-diamine 1007. N3-[2-(cyclobutoxy)ethyl]-N1-[1-(3,5- difluorophenyl)-1,2,4-triazol-3-yl]-5-methyl-benzene- 1,3-diamine 1008. 1-(3,4-difluorophenyl)-N-(2-fluoro-5-methyl-3- tetrahydrofuran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 1009. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-4-pyrrolidin-1-yl- pyrrolidin-3-ol 1010. 1-(3,5-difluorophenyl)-N-[3-[4-(2- methoxyethyl)-3-methyl-piperazin-1-yl]-5-methyl- phenyl]-1,2,4-triazol-3-amine 1011. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[2- (morpholinomethyl)pyrrolidin-1-yl]phenyl]-1,2,4- triazol-3-amine 1012. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(1-tetrahydropyran-4-yl-4- piperidyl)benzene-1,3-diamine 1013. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(4- tetrahydrofuran-3-yloxy-1-piperidyl)phenyl]-1,2,4- triazol-3-amine 1014. 2-[[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-phenyl]-4-piperidyl]-methyl- amino]ethanol 1015. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 4-fluoro-5-methyl-N1-(3-methyloxetan-3-yl)benzene- 1,3-diamine 1016. N-[3-[2-(diethylaminomethyl)morpholin-4-yl]- 5-methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol- 3-amine 1017. 1-(3,5-difluorophenyl)-N-[3-[2- [(dimethylamino)methyl]morpholin-4-yl]-5-methyl- phenyl]-1,2,4-triazol-3-amine 1018. 1-(3,5-difluorophenyl)-N-[3-(4-isopropoxy-1- piperidyl)-5-methyl-phenyl]-1,2,4-triazol-3-amine 1019. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[(3-pyrrolidin-1-yloxetan-3- yl)methyl]benzene-1,3-diamine 1020. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 4-fluoro-5-methyl-N1-tetrahydropyran-4-yl-benzene- 1,3-diamine 1021. N-[2-fluoro-5-methyl-3-[4-(oxetan-3- yl)piperazin-1- yl]phenyl]-1-(3-pyridyl)-1,2,4-triazol-3- amine 1022. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(2- methylmorpholin-4-yl)-1-piperidyl]phenyl]-1,2,4- triazol-3-amine 1023. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-3-methyl-piperazin-1-yl]- 2-methyl-propan-2-ol 1024. 1-(3,5-difluorophenyl)-N-[3-[4-(4- ethylpiperazin-1-yl)-1-piperidyl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 1025. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1-methyl-piperazin-2- yl]ethanol 1026. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[2- (pyrrolidin-1-ylmethyl)morpholin-4-yl]phenyl]-1,2,4- triazol-3-amine 1027. 1-(3,5-difluorophenyl)-N-(2-fluoro-5-methyl-3- tetrahydrofuran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 1028. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N3-[(1-methoxycyclobutyl)methyl]-5-methyl-benzene- 1,3-diamine 1029. 1-(3,5-difluorophenyl)-N-[3-[2-(2- methoxyethyl)morpholin-4-yl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 1030. 1-[3-[[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-anilino]methyl]azetidin-1- yl]ethanone 1031. N-[3-(2,2,3,3,4,4,5,5,6,6-decadeuterio-1- piperidyl)-5-(trifluoromethyl)phenyl]-1-(3,5- difluorophenyl)-1,2,4-triazol-3-amine 1032. 2-[2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5-methyl-phenyl]piperazin-1- yl]ethoxy]ethanol 1033. N-[3-(2-isopropyl-2,6-diazaspiro[3.3]heptan-6- yl)-5-methyl-phenyl]-1-phenyl-1,2,4-triazol-3-amine 1034. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(4-oxa-7- azaspiro[2.5]octan-7-yl)phenyl]-1,2,4-triazol-3-amine 1035. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]ethanol 1036. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- methylsulfonylazetidin-1-yl)phenyl]-1,2,4-triazol-3- amine 1037. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(4- pyrrolidin-1-yl-1-piperidyl)phenyl]-1,2,4-triazol-3- amine 1038. N-[3-[4-(3-deuteriotetrahydrofuran-3- yl)piperazin-1-yl]-5-methyl-phenyl]-1-phenyl-1,2,4- triazol-3-amine 1039. 1-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]pyrrolidin-3-yl]pyrrolidin- 3-ol 1040. cyclopropyl-[2,2,3,3,5,5,6,6-octadeuterio-4-[3- (difluoromethyl)-5-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]phenyl]piperazin-1-yl]methanone 1041. 1-(3,5-difluorophenyl)-N-[3-methyl-5- (2,2,3,3,5,5,6,6-octadeuterio-4-tetrahydrofuran-3-yl- piperazin-1-yl)phenyl]-1,2,4-triazol-3-amine 1042. 2-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-2-fluoro-5-methyl-phenyl]piperazin-1- yl]ethanol 1043. 1-[2,2,3,3,5,5,6,6-octadeuterio-4-[3-[[1-(3,5- difluorophenyl)-1,2,4-triazol-3-yl]amino]-5-methyl- phenyl]piperazin-1-yl]ethanone 1044. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-[1-(tetrahydrofuran-3-ylmethyl)-4- piperidyl]benzene-1,3-diamine 1045. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[(1-tetrahydropyran-4-yl-4- piperidyl)methyl]benzene-1,3-diamine 1046. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-[(1- methyl-3-piperidyl)methyl]piperazin-1-yl]phenyl]- 1,2,4-triazol-3-amine 1047. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-(2,6-dioxaspiro[4.5]decan-9-yl)-5-methyl-benzene- 1,3-diamine 1048. 5-methyl-N1-(5-methyloxazol-2-yl)-N3-(1- phenyl-1,2,4-triazol-3-yl)benzene-1,3-diamine 1049. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[1-(2-methoxyethyl)-3-piperidyl]-5-methyl- benzene-1,3-diamine 1050. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[2- (methylsulfonylmethyl)pyrrolidin-1-yl]phenyl]-1,2,4- triazol-3-amine 1051. N-(2-fluoro-5-methyl-3-tetrahydrofuran-3- yloxy-phenyl)-1-phenyl-1,2,4-triazol-3-amine 1052. 1-(3,5-difluorophenyl)-N-(2-fluoro-5-methyl-3- tetrahydrofuran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 1053. 1-[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-4-piperidyl]piperidin-3-ol 1054. 1-(3,4-difluorophenyl)-N-(2-fluoro-5-methyl-3- tetrahydrofuran-3-yloxy-phenyl)-1,2,4-triazol-3-amine 1055. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-2-ethyl-piperazin-1- yl]propan-2-ol 1056. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(8-oxa-4- azabicyclo[4.2.0]octan-4-yl)phenyl]-1,2,4-triazol-3- amine 1057. N-[3-methyl-5-[(1-phenyl-1,2,4-triazol-3- yl)amino]phenyl]cyclopropanecarboxamide 1058. N1-(1-cyclopropylethyl)-N3-[1-(3,5- difluorophenyl)-1,2,4-triazol-3-yl]-5-methyl-benzene- 1,3-diamine 1059. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- pyrrolidin-1-ylpyrrolidin-1-yl)phenyl]-1,2,4-triazol-3- amine 1060. N-(2-fluoro-5-methyl-3-tetrahydrofuran-3- yloxy-phenyl)-1-(3-fluorophenyl)-1,2,4-triazol-3-amine 1061. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[(4-methylmorpholin-3- yl)methyl]benzene-1,3-diamine 1062. 1-(3,5-difluorophenyl)-N-[3-[4-(2-ethoxyethyl)- 3-methyl-piperazin-1-yl]-5-methyl-phenyl]-1,2,4- triazol-3-amine 1063. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N1-(1-tetrahydrofuran-3-yl-4- piperidyl)benzene-1,3-diamine 1064. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-(2-methoxycyclopentyl)-5-methyl-benzene-1,3- diamine 1065. 1-(3,4-difluorophenyl)-N-[3-methyl-5- (2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)phenyl]- 1,2,4-triazol-3-amine 1066. 4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-1-(2- methoxyethyl)piperazin-2-one 1067. 1-(3,5-difluorophenyl)-N-[3-[4-(4-methoxy-1- piperidyl)-1-piperidyl]-5-methyl-phenyl]-1,2,4-triazol- 3-amine 1068. 1069. N1-(1-cyclobutyl-4-piperidyl)-N3-[1-(3,5- difluorophenyl)-1,2,4-triazol-3-yl]-5-methyl-benzene- 1,3-diamine 1070. 1-(3-fluorophenyl)-N-[3-(2-isopropyl-2,6- diazaspiro[3.3]heptan-6-yl)-5-methyl-phenyl]-1,2,4- triazol-3-amine 1071. 1-(3,5-difluorophenyl)-N-[2-fluoro-3-(2- isopropyl-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl- phenyl]-1,2,4-triazol-3-amine 1072. [4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]morpholin-2-yl]methanol 1073. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[4-(2- pyrrolidin-1-ylethoxy)-1-piperidyl]phenyl]-1,2,4- triazol-3-amine 1074. 1-[3-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-anilino]-3-methyl-azetidin-1-yl]-2- methoxy-ethanone 1075. 1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-3-methyl-azetidine-3- carbonitrile 1076. [1-[[1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol- 3-yl]amino]-5-methyl-phenyl]pyrrolidin-2- yl]methyl]pyrrolidin-2-yl]methanol 1077. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]piperazin-1-yl]-3- (dimethylamino)propan-2-ol 1078. [1-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-5-methyl-phenyl]-3-fluoro-azetidin-3- yl]methanol 1079. 5-deuterio-1-(3,5-difluorophenyl)-N-[3-methyl- 5-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-1,2,4-triazol- 3-amine 1080. 1-(3,5-difluorophenyl)-N-[3-(2-isopropyl-2,6- diazaspiro[3.3]heptan-6-yl)-5-methyl-phenyl]-1,2,4- triazol-3-amine 1081. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 5-methyl-N3-[2-(3-methylmorpholin-4- yl)ethyl]benzene-1,3-diamine 1082. 1-(3,5-difluorophenyl)-N-[3-methyl-5-(3- tetrahydrofuran-3-ylpyrrolidin-1-yl)phenyl]-1,2,4- triazol-3-amine 1083. tert-butyl 3-[[3-[[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]amino]-5-methyl-anilino]methyl]azetidine- 1-carboxylate 1084. N-[2-fluoro-5-methyl-3-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1-phenyl-1,2,4-triazol-3- amine 1085. N-[3-methyl-5-[4-[1,2,2,2-tetradeuterio-1- (trideuteriomethyl)ethyl]piperazin-1-yl]phenyl]-1- phenyl-1,2,4-triazol-3-amine 1086. N-[3-[2- (cyclopropylmethoxymethyl)morpholin-4-yl]-5- methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol-3- amine 1087. 1088. 1089. 1090. 5-deuterio-N-[3-methyl-5-[4-(oxetan-3- yl)piperazin-1-yl]phenyl]-1-[3- (trifluoromethyl)phenyl]-1,2,4-triazol-3-amine 1091. 2-[1-[3-[[5-deuterio-1-(3,5-difluorophenyl)- 1,2,4-triazol-3-yl]amino]-5-methyl-phenyl]azetidin-3- yl]propan-2-ol 1092. 1093. 2-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-4,5-dimethyl-phenoxy]-1-morpholino- ethanone 1094. N-[3-(2,2,3,3,4,4,5,5,6,6-decadeuterio-1- piperidyl)-5-(trifluoromethyl)phenyl]-1-(3,4- difluorophenyl)-1,2,4-triazol-3-amine 1095. cyclopropyl-[2,2,3,3,5,5,6,6-octadeuterio-4-[3- (difluoromethyl)-5-[[1-(3,4-difluorophenyl)-1,2,4- triazol-3-yl]amino]phenyl]piperazin-1-yl]methanone 1096. 1-(3,5-difluorophenyl)-N-[3-methyl-5-[3- (2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)azetidin-1- yl]phenyl]-1,2,4-triazol-3-amine 1097. 1-(3,4-difluorophenyl)-N-[3-methyl-5-[3- (2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)azetidin-1- yl]phenyl]-1,2,4-triazol-3-amine 1098. N-[3-(2,2,3,3,4,4,5,5,6,6-decadeuterio-1- piperidyl)-5-(difluoromethyl)phenyl]-1-(3,4- difluorophenyl)-1,2,4-triazol-3-amine 1099. cyclopropyl-[2,2,3,3,5,5,6,6-octadeuterio-4-[3- [[1-(3,4-difluorophenyl)-1,2,4-triazol-3-yl]amino]-5- (trifluoromethyl)phenyl]piperazin-1-yl]methanone 1100. N-[3-(2,2,3,3,4,4,5,5,6,6-decadeuterio-1- piperidyl)-5-(trifluoromethyl)phenyl]-1-(3- fluorophenyl)-1,2,4-triazol-3-amine 1101. N-[3-(2,2,3,3,4,4,5,5,6,6-decadeuterio-1- piperidyl)-5-(difluoromethyl)phenyl]-1-(3- fluorophenyl)-1,2,4-triazol-3-amine 1102. cyclopropyl-[2,2,3,3,5,5,6,6-octadeuterio-4-[3- [[1-(3-fluorophenyl)-1,2,4-triazol-3-yl]amino]-5- (trifluoromethyl)phenyl]piperazin-1-yl]methanone 1103. cyclopropyl-[2,2,3,3,5,5,6,6-octadeuterio-4-[3- (difluoromethyl)-5-[[1-(3-fluorophenyl)-1,2,4-triazol- 3-yl]amino]phenyl]piperazin-1-yl]methanone 1104. N-[3-(2,2,3,3,4,4,5,5,6,6-decadeuterio-1- piperidyl)-5-(trifluoromethyl)phenyl]-1-pyrazin-2-yl- 1,2,4-triazol-3-amine 1105. N-[3-(2,2,3,3,4,4,5,5,6,6-decadeuterio-1- piperidyl)-5-(difluoromethyl)phenyl]-1-pyrazin-2-yl- 1,2,4-triazol-3-amine 1106. cyclopropyl-[2,2,3,3,5,5,6,6-octadeuterio-4-[3- (difluoromethyl)-5-[(1-pyrazin-2-yl-1,2,4-triazol-3- yl)amino]phenyl]piperazin-1-yl]methanone 1107. N-[3-methyl-5-[4-(oxetan-3-yl)piperazin-1- yl]phenyl]-1-(2,3,4,5,6-pentadeuteriophenyl)-1,2,4- triazol-3-amine 1108. N3-benzyl-N1-[1-(3,5-difluorophenyl)-1,2,4- triazol-3-yl]-2-fluoro-5-methyl-benzene-1,3-diamine 1109. N-[3-[4-(3-deuteriooxetan-3-yl)piperazin-1-yl]- 5-methyl-phenyl]-1-(3,5-difluorophenyl)-1,2,4-triazol- 3-amine 1110. N-[3-methyl-5-(2,2,3,3,5,5,6,6-octadeuterio-4- methyl-piperazin-1-yl)phenyl]-1-phenyl-1,2,4-triazol- 3-amine 1111. [4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-2-fluoro-5-methyl-phenyl]piperazin-1-yl]- tetrahydropyran-4-yl-methanone 1112. 1-(3,5-difluorophenyl)-N-[2-fluoro-5-methyl-3- [3-methyl-4-(1-methyl-4-piperidyl)piperazin-1- yl]phenyl]-1,2,4-triazol-3-amine 1113. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- N1-[2-(2-ethylmorpholin-4-yl)ethyl]-2-fluoro-5- methyl-benzene-1,3-diamine 1114. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-5-methyl-N1-[1-(tetrahydrofuran-3-ylmethyl)- 4-piperidyl]benzene-1,3-diamine 1115. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-5-methyl-N1-[1-(tetrahydrofuran-2-ylmethyl)- 4-piperidyl]benzene-1,3-diamine 1116. 1-(3,5-difluorophenyl)-N-[2-fluoro-5-methyl-3- [3-(4-methylpiperazin-1-yl)azetidin-1-yl]phenyl]-1,2,4- triazol-3-amine 1117. N3-[(4-cyclopropylmorpholin-2-yl)methyl]-N1- [1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]-2-fluoro-5- methyl-benzene-1,3-diamine 1118. N3-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-5-methyl-N1-(1-methyl-2-morpholino- ethyl)benzene-1,3-diamine 1119. 1-(3,5-difluorophenyl)-N-[2-fluoro-3-[2- (isopropoxymethyl)morpholin-4-yl]-5-methyl-phenyl]- 1,2,4-triazol-3-amine 1120. N1-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]- 2-fluoro-5-methyl-N3-[(1- morpholinocyclopropyl)methyl]benzene-1,3-diamine 1121. 1-(3,5-difluorophenyl)-N-[2-fluoro-5-methyl-3- (3-tetrahydrofuran-3-ylazetidin-1-yl)phenyl]-1,2,4- triazol-3-amine 1122. 1-[4-[3-[[1-(3,5-difluorophenyl)-1,2,4-triazol-3- yl]amino]-2-fluoro-5-methyl-phenyl]-2-methyl- piperazin-1-yl]-2-methyl-propan-2-ol

Metadata:
- Claim Count in Document: 2.0
- Percentile: 97.0
- Lexical Diversity: 1.53846
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15173177', '15037090', '15287922', '14509793', '11703522']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.794851090722294
- 35 USC 102 Novelty (BERT): 0.6368194952178187
- Combined Prediction Score: 0.7790479311718465
- Mean Citation Score: 421.580412
- Max Citation Score: 592.3917
- Similarity Product: 563.7264829226018

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test