PATENT CLAIM ANALYSIS

Application Number: 16226070
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "210200"]

Abstract:
Provided are a pyrimidine compound represented by Formula 1, a method of preparing the same, and a pharmaceutical use of the pyrimidine compound for the prevention or treatment of cancer.

Claim (Index 1):
A compound selected from a substance of Formula 1 and a pharmaceutically acceptable salt thereof: wherein, in Formula 1, R 1  is hydrogen, a halogen, a hydroxy group, or a C 1-4  alkoxy group, R 2  is hydrogen, a halogen, a cyano group, a nitro group, an amino group, a carboxamide group, a formyl group, a halo C 1-4  alkyl group, or a C 1-4  alkyl group, R 3  is hydrogen, a halo C 1-4  alkyl group, a C 1-4  alkyl group, a C 2-4  alkenyl group, or a C 2-4  alkynyl group, R 4 (s) are each independently a halogen, a hydroxy group, a cyano group, a nitro group, an amino group, \u2014SR c , \u2014S(\u2550O)R c , \u2014S(\u2550O) 2 R c , a halo C 1-4  alkyl group, a C 1-4  alkoxy group, a hydroxy C 1-4  alkyl group, a C 1-4  alkyl group, a C 2-4  alkenyl group, a C 2-4  alkynyl group, \u2014NR a R b , \u2014CO 2 R b , or \u2014CO\u2014NR a R b , wherein, R a  and R b  are each independently hydrogen or a C 1-6  alkyl group, and R c  is a C 1-4  alkyl group or \u2014NR a R b , k is an integer from 0 to 4, R 5  and R 6  are each independently hydrogen, a halogen, a hydroxy group, a nitro group, an amino group, a C 1-4  alkoxy group, a hydroxy C 1-4  alkyl group, a C 1-4  alkyl group, a C 2-4  alkenyl group, a C 2-4  alkynyl group, a C 3-10  cycloalkyl group, or a C 3-9  heterocycloalkyl group, wherein, the C 3-10  cycloalkyl group and the C 3-9  heterocycloalkyl group are each independently unsubstituted or substituted with a halogen, a C 1-4  alkyl group, or a halo C 1-4  alkyl group, R 7  is hydrogen, a linear or branched C 1-6  alkyl group, a C 3-7  cycloalkyl group, a C 3-9  heterocycloalkyl group, or a C 1-4  alkoxy group, Y is a direct bond, \u2014(CH 2 ) m \u2014, \u2014O\u2014, \u2014O(CH 2 ) m \u2014, \u2014(CH 2 ) m O\u2014, \u2014C(\u2550O)\u2014, \u2014NR 9 \u2014, \u2014SO 2 \u2014, \u2014(CH 2 ) m \u2014O\u2014(CH 2 ) n \u2014, \u2014CO(CH 2 ) m \u2014, \u2014(CH 2 ) m CO\u2014, \u2014(CH 2 ) m \u2014CO\u2014(CH 2 ) n \u2014, \u2014(CH 2 ) m NR 9 \u2014, \u2014NR 9 (CH 2 ) m \u2014, \u2014(CH 2 ) m \u2014NR 9 \u2014(CH 2 ) n \u2014, \u2014(CH 2 ) m SO 2 \u2014, \u2014SO 2 (CH 2 ) m \u2014, or \u2014(CH 2 ) m \u2014SO 2 \u2014(CH 2 ) n \u2014, wherein R 9  is hydrogen, a C 1-4  alkyl group, a C 3-10  cycloalkyl group, or a C 3-9  heterocycloalkyl group, and m and n are each independently an integer from 1 to 3, Z is represented by Formula 2: wherein, in Formula 2, \u2003is a C 3-10  cycloalkyl group or a C 2-11  heterocycloalkyl group, R 10 (s) are each independently a halogen, a hydroxy group, a cyano group, a nitro group, an amino group, a thiol group, a formyl group, a linear or branched halo C 1-4  alkyl group, a linear or branched C 1-4  alkoxy group, a linear or branched hydroxy C 1-4  alkyl group, a linear or branched C 1-4  alkyl group, a linear or branched hydroxy C 1-4  alkylcarbonyl group, a C 2-4  alkenyl group, a C 2-4  alkynyl group, a C 3-10  cycloalkyl group, a C 2-9  heterocycloalkyl group, a hydroxy C 2-9  heterocycloalkyl group, \u2014NR 11 R 12 , \u2014COR 13 , \u2014COOR 13 , or \u2014SO 2 R 14 , R 11  and R 12  are each independently hydrogen, a linear or branched hydroxy C 1-4  alkyl group, a linear or branched halo C 1-4  alkyl group, a linear or branched C 1-4  alkyl group, a C 2-4  alkenyl group, or a C 2-4  alkynyl group, R 13  is hydrogen, a hydroxy group, a hydroxy C 1-4  alkyl group, a halo C 1-4  alkyl group, a C 1-4  alkyl group, a C 2-4  alkenyl group, a C 2-4  alkynyl group, a C 3-10  cycloalkyl group, or a C 2-9  heterocycloalkyl group, R 14  is a hydroxy group, a halo C 1-4  alkyl group, a C 1-4  alkyl group, a C 2-4  alkenyl group, a C 2-4  alkynyl group, a C 3-10  cycloalkyl group, a C 2-9  heterocycloalkyl group, an aryl group, or \u2014NR a R b , and q is an integer from 0 to 5.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 98.0
- Lexical Diversity: 1.375
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16127487', '15319151', '12843494', '15565897', '12002340']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8131153738969814
- 35 USC 102 Novelty (BERT): 0.6118657161783086
- Combined Prediction Score: 0.7929904081251142
- Mean Citation Score: 352.326112
- Max Citation Score: 527.59644
- Similarity Product: 524.1082538600779

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test