PATENT CLAIM ANALYSIS

Application Number: 16012219
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["436", "076000"]

Abstract:
Compounds of general formula I wherein Fc and Fc′ may be the same or different and are substituted ferrocenyl moieties having at least one ring substituent selected from sulfur-containing groups, phosphorus-containing groups, iodo, chloro, silyl, fluoroalkyl groups containing two or more fluorine atoms, heteroaryl, substituted phenyl, and cyano, wherein if present as sole substituent the cyano group is located on the proximal cyclopentadienyl ring; X is a spacer, Y is a spacer, Z is a spacer; and R is a linker group. Compound I may be used to make labelled substrates, functionalised compounds for making labelled substrates and may be used as labels in an electrochemical assay.

Claim (Index 3):
A method of detecting a nucleic acid, the method comprising:\n contacting the nucleic acid with a complementary nucleic acid probe labeled with a compound according to general formula I under conditions to allow hybridization between the complementary nucleic acid probe and the nucleic acid and thereby forming either a hybridized or an unhybridized nucleic acid probe, wherein general formula I is in which: Fc is a substituted ferrocenyl moiety having at least one ring substituent selected from chloro; Fc\u2032 is a substituted ferrocenyl moiety having at least one substituent selected from chloro; X represents \u2014(CH 2 ) x \u2014 in which x is from 1 to 6; Y represents \u2014(CH 2 ) y \u2014 in which y is from 1 to 6; Z represents C6 to C8 alkylene; and R is a hydroxyl group, followed by the step of selectively degrading either the hybridized or the unhybridized nucleic acid probe with a single- or double-strand specific nuclease; and measuring an electrochemical activity of the compound labelling the complementary nucleic acid probe, wherein the electrochemical activity is dependent either quantitatively or qualitatively on the extent of degradation of the hybridized or the unhybridized nucleic acid probe.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 94.0
- Lexical Diversity: 1.5974
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15906241', '15908133', '15026454', '10555351', '14603555']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6437213186489609
- 35 USC 102 Novelty (BERT): 0.5177600242374836
- Combined Prediction Score: 0.6311251892078131
- Mean Citation Score: 243.77685800000003
- Max Citation Score: 338.95023
- Similarity Product: 260.1972479522717

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test