PATENT CLAIM ANALYSIS

Application Number: 15974817
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "450000"]

Abstract:
The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.

Claim (Index 33):
A formulation comprising a plurality of liposomes comprised of an amount of lipid ingredient and therapeutic agent, said lipid ingredient comprising DSPC, DSPG and cholesterol in a molar ratio of about 3:1:2, and a mass ratio of said therapeutic agent to lipid is in a range of about 1:5 to 1:8, wherein the liposomes have compressibility no greater than 0.70 ml/g, and wherein the liposomes have osmolality internal to the liposome in a range of 340-440 mO/kg, said formulation manufactured by steps of:\n (a) mixing a solution containing a therapeutic agent with a solution containing lipids comprising DSPC, DSPG and cholesterol in the molar ratio of about 3:1:2 to form multi-lamellar vesicles such that the mass ratio of said therapeutic agent to lipid is in the range of about 1:5 to 1:8, (b) extruding the multi-lamellar vesicles consisting essentially of extruding through a single filter multiple times, said filter having a pore size about 100 nm, and (c) ultrafiltrating the multi-lamellar vesicles.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 93.0
- Lexical Diversity: 1.73333
- Patent Class: 424.0
- Transitional Phrase Type: half
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13804707', '13130525', '11921022', '14352662', '15891170']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7487115809309901
- 35 USC 102 Novelty (BERT): 0.6070618753571252
- Combined Prediction Score: 0.7345466103736037
- Mean Citation Score: 352.36861800000014
- Max Citation Score: 568.1460599999998
- Similarity Product: 451.32979858038414

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test