PATENT CLAIM ANALYSIS

Application Number: 15774223
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["424", "233100"]

Abstract:
Compositions and methods are provided for modulating adeno-associated virus (AAV) infection. For example, compositions and methods are provided for enhancing permissiveness of a target cell to AAV infection (e.g., by increasing levels of AAVR (KIAA0319L) in the cell), for reducing permissiveness of a target cell to AAV infection (e.g., by reducing levels of AAVR in the cell), and for nucleic acid delivery (e.g., by (i) increasing permissiveness of a target cell to AAV infection, e.g., by increasing the amount of AAVR in the cell; and (ii) contacting the target cell with an AAV particle that includes a nucleic acid of interest). Also provided are screening methods and kits for practicing the methods of the disclosure.

Claim (Index 78):
A method of identifying a variant adeno-associated virus (AAV) capsid protein with altered binding to a target protein, the method comprising:\n contacting the target protein with a candidate AAV capsid protein comprising a mutated amino acid sequence compared to a corresponding wild type capsid protein; measuring the binding of the candidate AAV capsid protein to the target protein; determining that the candidate AAV capsid protein exhibited increased or decreased binding to the target protein relative to a reference AAV capsid protein; and determining that the candidate AAV capsid protein is an AAV with altered binding to the target protein relative to the reference AAV capsid protein, wherein the target protein is selected from: adeno-associated virus receptor (AAVR) (KIAA0319L), GPR108, and TM9SF2.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 93.0
- Lexical Diversity: 2.66038
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10880297', '15367734', '15681267', '15435212', '13840224']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6984365040968648
- 35 USC 102 Novelty (BERT): 0.522089882942971
- Combined Prediction Score: 0.6808018419814754
- Mean Citation Score: 312.9323080000001
- Max Citation Score: 317.23126
- Similarity Product: 248.2995361732936

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test