PATENT CLAIM ANALYSIS

Application Number: 15874093
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["549", "541000"]

Abstract:
The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R 10  is a linear or branched C 1-6  alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

Claim (Index 24):
The method of  claim 23 , further comprising the steps of:\n iv) refluxing the compound of Formula 1a in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%; v) reacting the compound of Formula 1 with TBSCl under basic conditions to generate the compound of Formula 2a; vi) reacting the compound of Formula 2a with 1-TMS-1-propyne to generate the compound of Formula 3a; and vii) converting the compound of Formula 3a to the compound of Formula 5a.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 86.0
- Lexical Diversity: 1.71053
- Patent Class: 549.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15852922', '15036219', '15583457', '13541504', '13940421']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7185156179898284
- 35 USC 102 Novelty (BERT): 0.6029994525024578
- Combined Prediction Score: 0.7069640014410914
- Mean Citation Score: 382.435956
- Max Citation Score: 509.06766
- Similarity Product: 486.6473065808559

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test