PATENT CLAIM ANALYSIS

Application Number: 15942321
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "210020"]

Abstract:
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Claim (Index 17):
The compound of  claim 1 , wherein R 2  is: wherein, v is 0, 1, 2 or 3; and\n R 5 , in each instance, is independently selected from the group consisting of C 1-6  alkyl, halogen, cyano, cyano(C 1-6  alkyl)-, \u2014CF 3 , \u2014CHF 2 , hydroxy(C 1-6  alkyl), halo(C 1-6  alkyl), hydroxyl, (C 1-6  alkyl)-O\u2014(C 1-6  alkyl)-, \u2014(C 1-6  alkyl)-NHC(O)\u2014(C 1-6  alkyl), amino, \u2014NR\u2032C(O)R\u2033, acetyl, di(C 1-6  alkyl)amino, mono(C 1-6  alkyl)amino, amino(C 1-6  alkyl), C 1-6  alkoxy, CH 3 CO 2 \u2014(C 1-6  alkyl)-, \u2014NR\u2032SO 2 R\u2033, \u2014SO 2 R\u2032, \u2014SO 2 NR\u2032R\u2033, \u2014C(O)NR\u2032R\u2033, \u2014NR\u2032C(O)OR\u2033, \u2014NR\u2032C(O)NR\u2032R\u2033, optionally substituted C 2-9  heteroaryl, optionally substituted C 2-9  heterocyclyl, optionally substituted C 6-10  aryl, optionally substituted C 3-9  cycloalkyl, optionally substituted C 3-9  cycloalkyl-C(O)\u2014, and NR e R f \u2014C(O)\u2014(C 1-6  alkyl) k -,\n wherein said C 2-9  heteroaryl, C 2-9  heterocyclyl, and C 6-10  aryl can be optionally substituted with C 1-6  alkyl or (C 1-6  alkyl)-O\u2014(C 1-6  alkyl)-, wherein said (C 1-6  alkyl)-O\u2014(C 1-6  alkyl)- may be optionally substituted with amino, \n wherein, in each instance, R\u2032 and R\u2033 are independently H or C 1-6  alkyl, \n wherein R e  and R f  are each independently selected from the group consisting of hydrogen and branched or linear C 1-6  alkyl, or R e  and R f  together with the nitrogen to which each is bound can form a C 3-7  cycloalkyl, which can be optionally substituted (e.g., with branched or linear C 1-6  alkyl, C 3-4  cycloalkyl, halogen, cyano, \u2014CF 3 , \u2014CHF 2 , or hydroxyl); \n and k is 1 or 0.

Metadata:
- Claim Count in Document: 140.0
- Percentile: 90.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12530648', '13102720', '15281923', '13266976', '15852639']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7853794443333009
- 35 USC 102 Novelty (BERT): 0.5090182281041955
- Combined Prediction Score: 0.7577433227103904
- Mean Citation Score: 269.39763800000003
- Max Citation Score: 276.27457000000004
- Similarity Product: 215.5910005788881

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test