PATENT CLAIM ANALYSIS

Application Number: 15914587
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "450000"]

Abstract:
Provided are a pharmaceutical composition of an amorphous vortioxetine or a salt thereof, and a preparation method therefor. The pharmaceutical composition comprises an amorphous vortioxetine or a pharmaceutically acceptable salt thereof and two or more pharmaceutical excipients. The pharmaceutical composition has good stability and dispersity, and enhances the dissolution of vortioxetine or the pharmaceutically acceptable salt thereof, thereby improving the bioavailability of the medicinal formulation and the body absorption of the medicine.

Claim (Index 17):
A method for preparing a pharmaceutical composition of  claim 4 , comprising the following steps:\n 1) mixing vortioxetine hydrobromide, an organic carrier and an adsorbent in a solvent, at a temperature of \u221250\u02dc150\u00b0 C., to form a solution or suspension of the vortioxetine hydrobromide, organic carrier and adsorbent, wherein the weight ratio of vortioxetine hydrobromide to the solvent is from 0.001\u02dc100:1, the weight ratio of vortioxetine hydrobromide to the organic carrier is from 1:0.1\u02dc10, and the weight ratio of vortioxetine hydrobromide and the adsorbent is 1:0.1\u02dc10; and 2) removing the solvent in the solution or suspension obtained in step 1) to obtain a pharmaceutical composition of amorphous vortioxetine hydrobromide salt.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 90.0
- Lexical Diversity: 1.95
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14916075', '15304929', '14429388', '15048868', '14902326']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7630421028308096
- 35 USC 102 Novelty (BERT): 0.5375621437595087
- Combined Prediction Score: 0.7404941069236796
- Mean Citation Score: 348.08949
- Max Citation Score: 392.5238
- Similarity Product: 260.07009555277824

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test