PATENT CLAIM ANALYSIS

Application Number: 16423362
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-09
Patent Classification: ["514", "249000"]

Abstract:
The invention provides compounds effective as inhibitors of monocarboxylate transporters such as MCT1 and MCT4, which can be used for treatment of medical conditions wherein treatment of the condition with a compound having an inhibitor effect on MCT1, MCT4, or both is medically indicated. Compounds of the invention can have antitumor, antidiabetes, anti-inflammatory, or immunosuppressive pharmacological effects, and can be effective for treatment of cancer and of type II diabetes.

Claim (Index 1):
A MCT-inhibitory compound of formula A or of formula B wherein\n R 1  and R 2  are each independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )branched alkyl, (C 3 -C 7 )cycloalkyl, (C 1 -C 6 )fluoroalkyl, a (C 6 -C 10 )aryl ring system, a 5- to 9-membered heteroaryl ring system, a (C 1 -C 6 )alkyl-(C 6 -C 10 )aryl ring system, and a (C 1 -C 6 )alkyl-(5- to 9-membered)heteroaryl ring system; \n provided that when R 2  comprises an aryl or heteroaryl ring system, the ring system bears 0-2 independently selected substituents from the group consisting of fluoro, chloro, trifluoromethyl, (C 1 -C 6 )alkoxy, and (C 1 -C 6 )fluoroalkoxy; \n E is CH 2 , CH(C 1 -C 6 )alkyl, or CH(C 3 -C 7 )cycloalkyl; \n J is O, S, S(O), S(O) 2 , NH, N(C 1 -C 6 )alkyl, or NC(\u2550O)(C 1 -C 6 )alkyl; \n R 3  is a monocyclic or bicyclic (C 6 -C 10 )aryl or a monocyclic or bicyclic (5- to 10-membered) heteroaryl group wherein the aryl or heteroaryl can be substituted or unsubstituted; \n R 4  is hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )branched alkyl, (C 1 -C 6 )fluoroalkyl, (C 3 -C 7 )cycloalkyl, a (4- to 7-membered)heteroaryl, or a monocyclic or bicyclic (C 6 -C 10 )aryl or a monocyclic or bicyclic (5- to 10-membered) heteroaryl group wherein the aryl or heteroaryl can be substituted or unsubstituted; \n Z is a bond, or is \u2014O\u2014, \u2014CH 2 \u2014, \u2014CH(Me)\u2014, \u2014S\u2014, \u2014NH\u2014, or \u2014N(C1-C6)alkyl; \n n=1, 2, 3, or 4; \n the cyclic group indicated as \u201cring\u201d is an aryl or heteroaryl group of any one of the following formulas: \n wherein wavy lines indicate points of bonding, and wherein each M is an independently selected CH or N, provided that M group is a nitrogen atom in one or two instances; G is S, O, NH, NMe, or NCF 3 ; T is independently at each occurrence CH or N; wherein R 5  is optionally present, R 5  being one to four instances of independently selected F, Cl, Br, CF 3 , (C 1 -C 6 )alkyl, OCF 3 , O(C 1 -C 6 )alkyl, or CO\u2014(C 1 -C 6 )alkyl; or, the cyclic group indicated as \u201cring\u201d is a (C 3 -C 7 )cycloalkyl or a saturated (3- to 7-membered)heterocyclyl comprising 1-2 heteroatoms selected from the group consisting of O, NH, N(C1-C6)alkyl, and N(C1-C6)fluoroalkyl; wherein the points of bonding may be cis or trans; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 100.0
- Lexical Diversity: 1.51923
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15545152', '15545168', '15545117', '15575037', '09881913']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7515871203508581
- 35 USC 102 Novelty (BERT): 0.6499192658174568
- Combined Prediction Score: 0.7414203348975179
- Mean Citation Score: 407.02444
- Max Citation Score: 602.3753
- Similarity Product: 596.1215134731591

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test