PATENT CLAIM ANALYSIS

Application Number: 15906078
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "001100"]

Abstract:
Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

Claim (Index 1):
A method for determining the amount of thyroglobulin in a test sample, comprising:\n (a) adding a thyroglobulin peptide standard in said test sample containing thyroglobulin peptides, wherein one or more valine of the thyroglobulin peptide standard is isotopically labeled with  13 C,  15 N; (b) enriching said thyroglobulin peptides and thyroglobulin peptide standard from step (a); (c) ionizing said thyroglobulin peptides and thyroglobulin peptide standard from step (b) to produce one or more thyroglobulin peptide ions and thyroglobulin peptide standard ions detectable by mass spectrometry; and (d) detecting the amount of the ion(s) from step (c) by mass spectrometry; wherein the amount of the ion(s) detected in step (c) is related to the amount of thyroglobulin in said test sample and the amount of thyroglobulin peptide standard that was digested in step (a).

Metadata:
- Claim Count in Document: 17.0
- Percentile: 88.0
- Lexical Diversity: 1.875
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14031678', '14689542', '15443805', '13198620', '13859551']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8534352604997473
- 35 USC 102 Novelty (BERT): 0.6364363546559954
- Combined Prediction Score: 0.831735369915372
- Mean Citation Score: 623.969934
- Max Citation Score: 636.9141
- Similarity Product: 556.2444650246143

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test