PATENT CLAIM ANALYSIS

Application Number: 16299675
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-09
Patent Classification: ["424", "465000"]

Abstract:
The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.

Claim (Index 35):
A pharmaceutical composition in a unit dose form comprising one or a plurality of granules, pellets, particles or mini-tablets, wherein the composition comprises:\n (a) a solid dispersion in an amount from 30 to 40 percent by weight of the composition; (b) a binary filler; (c) a sweetener; (d) a disintegrant; (e) a glidant; and (f) a lubricant; wherein the unit dose form comprises from 1 mg to 250 mg of substantially amorphous or amorphous Compound 1, wherein the solid dispersion comprises about 80 wt % of substantially amorphous or amorphous N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) by weight of the dispersion, about 19.5 wt % of hydroxypropylmethylcellulose acetate succinate (HPMCAS) by weight of the dispersion, and about 0.5 wt % sodium lauryl sulfate (SLS) by weight of the dispersion, wherein the binary filler comprises mannitol and lactose in a ratio of about 1:3 mannitol to lactose, wherein the sweetener is sucralose, and wherein substantially amorphous Compound 1 has less than 15% crystallinity.

Metadata:
- Claim Count in Document: 92.0
- Percentile: 99.0
- Lexical Diversity: 1.39024
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15181114', '14286856', '15253636', '13942617', '15342999']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7390734722002643
- 35 USC 102 Novelty (BERT): 0.5447618476520542
- Combined Prediction Score: 0.7196423097454433
- Mean Citation Score: 325.633298
- Max Citation Score: 420.53372
- Similarity Product: 285.8415892492247

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test