PATENT CLAIM ANALYSIS

Application Number: 15779929
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["548", "435000"]

Abstract:
The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

Claim (Index 1):
A norbornenone compound of Formula 1, or a biologically or pharmaceutically acceptable salt thereof: wherein R 1 , R 2 , R 3  and R 4 , are each independently selected from hydrogen, halo, CN, NO2, OC(O)R 5 , C(O)R 5 , C(O)OR 5 , OR 5 , OS(O) 2 R 5 , NR 5 R 6 , SR 5 , C 1-20 alkyl, C 2-20 alkenyl, C 2-20 alkynyl, monocyclic and polycyclic carbocyclyl or heterocyclyl, polyethylene glycol, amino acid, and saccharide; wherein the C 1-20 alkyl, C 2-20 alkenyl, C 2-20 alkynyl, are each optionally interrupted with one or more heteroatoms selected from O, N and S; and wherein the C 1-20 alkyl, C 2-20 alkenyl, C 2-20 alkynyl, carbocycle, and heterocycle, are each optionally substituted with 1-3 substituents independently selected from halo, CN, NO 2 , OC(O)R 5 , C(O)R 5 , C(O)OR 5 , OR 5 , OS(O) 2 R 5 , NR 5 R 6 , SR 5 , polyethylene glycol, amino acid, and saccharide; and R 5  and R 6  are each independently selected from hydrogen, C 1-10 alkyl, and C 1-10 haloalkyl; and wherein two or more of R 1 , R 2 , R 3  and R 4 , may together form an optionally substituted monocyclic or polycyclic carbocyclyl or heterocyclyl; X is selected from halo, NO 2 , ONO 2 , OP(O)(OR 7 ), OC(O)R 7 , OS(O) 2 R 7 , OS(O) 2 OR 7 , SR 7 , S(O)R 7 , S(O) 2 R 7 , OR 7 , and NR 7 R 8 ; and R 7  and R 8  are each independently selected from hydrogen, C 1-10 alkyl, C 1-10 haloalkyl, aryl, arylalkyl and arylhaloalkyl; A 1  and A 2  are each independently selected from hydrogen, halo, CN, NO 2 , S(O)R 9 , S(O) 2 R 9 , S(O) 2 OR 9 , SR 9 , NR 9 R 10 , C(\u2550O)R 9 , C(\u2550S)R 9 , C(\u2550CR 10 R 11 )R 9 , or A 1  and A 2  together form an optionally substituted monocyclic or polycyclic carbocyclyl or heterocyclyl; R 9  is selected from hydrogen, hydroxyl, C 1-20 alkyl, C 1-20 haloalkyl, aryl, arylalkyl and arylhaloalkyl; and R 10  and R 11  are each independently selected from hydrogen, C 1-10 alkyl, and C 1-10 haloalkyl; with the proviso that a compound of Formula 1 does not include any of the following compounds: 3,3a,5,6-tetrachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene-1,8-dione; (1\u03b1,4\u03b1,4a\u03b2,4b\u03b1,5\u03b2,8\u03b2,8a\u03b1\u03b2,12b\u03b2)8a,12b-dibromo-1,2,3,4,5,6,7,8-octachloro-1,4,4a,4b,5,8,8a,12b-octahydro-1,4:5,8-dimethanotriphenylene-13,14-dione; 4,7,7a-tribromo-3a,4,7,7a-tetrahydro-2,3,5,6-tetraphenyl-4,7-methano-1H-indene-1,8-dione; 7,7a-dibromo-2,3,4,5-tetrachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene-1,8-dione; 4,7a-dibromo-2,3,6,7-tetrachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene-1,8-dione; methyl (2-exo,3-endo)-3-nitro-7-oxo-1,4,5,6-tetraphenyl-bicyclo[2.2.1]hept-5-ene-2-carboxylate; 1,2,3,4-tetraphenyl-5-(phenylthio)-bicyclo[2.2.1]hept-2-en-7-one; 2-[(4-bromophenyl)thio]-1,2,3,4-tetrahydro-1,4-diphenyl-1,4-methanotriphenylen-13-one; (1\u03b1,4\u03b1,5\u03b2)-1,4-dimethyl-2,3-diphenyl-5-(phenylsulfinyl)-bicyclo[2.2.1]hept-2-en-7-one.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.225
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11311731', '11338587', '12643641', '10561153', '11785998']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7718015137863304
- 35 USC 102 Novelty (BERT): 0.5280127433072062
- Combined Prediction Score: 0.747422636738418
- Mean Citation Score: 294.66267
- Max Citation Score: 354.02344
- Similarity Product: 257.7785208654452

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test