PATENT CLAIM ANALYSIS

Application Number: 16304634
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-09
Patent Classification: ["540", "575000"]

Abstract:
Relating to processes for preparing suvorexant or its pharmaceutically acceptable salts through the formation of a cocrystal of (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate hydrochloride with (R)-(+)-1,1,2-triphenyl-1,2-ethanediol ((R)-TED). This cocrystal provides the resolution of an intermediate of suvorexant, in particular, of (rac)-benzyl5-methyl-1,4-diazepane-1-carboxy-lateor a hydrochloride salt thereof. It also relates to a new cocrystal useful in such preparation processes.

Claim (Index 13):
A process for preparing suvorexant of formula (I) or a pharmaceutically acceptable salt thereof, which comprises: a) carrying out the resolution process of  claim 5  to yield (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate of formula (R)-(III) or a hydrochloride salt thereof, b) N-acylating a compound of formula (R)-(III), with a benzoic acid derivative of formula (IV) wherein X is OH or Cl, optionally in the presence of a base, to yield a compound of formula (V); wherein Cbz in compound (R)-(III) and (V) is benzyloxycarbonyl;\n c) deprotecting the amino group of the compound of formula (V) thus obtained to provide the compound of formula (VI); \n d) coupling the compound obtained in step c) with a benzoxazole derivative of formula (VII) wherein Y is H, Cl or Br; to yield suvorexant (I) or a pharmaceutically acceptable salt thereof; and\n e) if desired, converting the resulting suvorexant free base into a pharmaceutically acceptable salt thereof by reacting it with a pharmaceutically acceptable acid.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 98.0
- Lexical Diversity: 1.60417
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16073929', '15501295', '12061499', '13147337', '10536618']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6566538078176272
- 35 USC 102 Novelty (BERT): 0.5178720305653578
- Combined Prediction Score: 0.6427756300924004
- Mean Citation Score: 238.975446
- Max Citation Score: 276.726
- Similarity Product: 208.03266100931168

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test