PATENT CLAIM ANALYSIS

Application Number: 16133322
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-08
Patent Classification: ["424", "451000"]

Abstract:
The present invention is directed to a System characterization of NASH that combines Modeling and Biomarkers, enabling pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and/or prevention of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH). Said conditions are Liver related complications among the array of manifestations of metabolic syndromes, including Type 2 diabetes, hyperlipidemia, weight gain, abdominal obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory states that lead to these manifestations, among others. In additional aspects, the present invention relates to compositions and methods which may be used to treat, inhibit or reduce the likelihood of NASH and NAFLD complications in patients with hepatitis viral infections, including Hepatitis B and Hepatitis C viral infections, as well as the secondary disease states and/or conditions which are often associated with such viral infections, including hepatic steatosis (steatohepatitis), cirrhosis, fatty liver and hepatocellular cancer, metabolic syndrome complications including cardiovascular diseases, neurodegenerative diseases and premature ageing, among other disease states or conditions.

Claim (Index 75):
The method of  claim 73 , wherein said FS index is calculated as: 0.11 \ue89e ( ( FBG + TG ) + HBA \ue89e \ue89e 1 \ue89e c \u00d7 HBA \ue89e \ue89e 1 \ue89e c \u00d7 20 5 + BMI \u00d7 FBG + TG 150 + AST \u00d7 TG \u00d7 4 100 + FB \ue89e \ue89e insulin \u00d7 ( BMI - 22 ) ) S / D \ue89e \ue89e ratio FBG is Fasting Blood Glucose in mg/dl and normal value is 100 mg/dl TG is Triglycerides in mg/dl normal value is <150 HBA1c is glycosylated hemoglobin calculated as a ratio to hemoglobin; normal value is <6% BMI is body mass index as kg/m 2  where a normal value is 20 and obese begins above 25 AST is Aspartate Transferase (formerly SGOT) in IU/liter and a normal value is 5.50 FB insulin if fasting Blood insulin concentration in nmol/liter, a normal value is 4.0 Where S/D ratio is the Glucose \ue89e \ue89e Supply \ue89e \ue89e ( S ) / Insulin \ue89e \ue89e Demand \ue89e \ue89e ( D ) = 1 + ( ( CE ) + ( HGU ) + ( GNG ) + ( IR ) ) 1 + ( PIE + PGU ) Where S/D ratio (SD) is a ratio of Glucose Supply Index (S) to Insulin Demand Index (D); and wherein (S) is calculated as follows:\n 1+[aggregate of carbohydrate exposure (CE)+hepatic glucose uptake (HGU)+hepatic gluconeogenesis (GNG) and+insulin resistance (IR)], \n and (D) is calculated as follows:\n 1+[aggregate of peripheral glucose uptake (PGU)+peripheral insulin exposure (PIE)].

Metadata:
- Claim Count in Document: 35.0
- Percentile: 97.0
- Lexical Diversity: 1.78571
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14002642', '15162941', '15624275', '14677044', '13754855']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7418253703472342
- 35 USC 102 Novelty (BERT): 0.581388202188023
- Combined Prediction Score: 0.7257816535313131
- Mean Citation Score: 399.312976
- Max Citation Score: 502.13965
- Similarity Product: 376.0341547353984

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test