PATENT CLAIM ANALYSIS

Application Number: 15934660
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "678000"]

Abstract:
Derivatives of 6-shogaol are described herein. Also described herein are methods of preparing the derivatives, as well as methods of using the derivatives to activate Nrf2 and to treat diseases associated with inflammation and/or oxidative stress.

Claim (Index 1):
A method of treating a disease associated with inflammation and/or oxidative stress in a subject in need thereof, wherein the disease is treatable by the activation of Nrf2, wherein the method comprises administering to the subject a therapeutically effective amount of a compound having a structure of the formula: wherein:\n \u2018a\u2019 and \u2018b\u2019 are each independently a single bond or a double bond; \n m is an integer between 0 and 4; \n R 1  is \u2014H, halogen, halogen-substituted C 1 -C 4  alkoxy, \u2014COOH, or halogen-substituted C 1 -C 4  alkyl; \n R 2  is\u2014H, halogen, \u2014OH, halogen-substituted C 1 -C 4  alkoxy, \u2014COOH, or halogen-substituted C 1 -C 4  alkyl; and \n R 3  and R 4  are independently selected from the group consisting of \u2014H, \u2014OH, amino, C 1 -C 4  alkyl, C 1 -C 4  alkylamino, and C 1 -C 4  alkoxy, subject to the proviso that when R 1  and R 2  are each \u2014H, R 3  and R 4  are each independently selected from \u2014OH and C 1 -C 4  alkoxy, and subject to the proviso that when R 4  is methoxy, R 1  is \u2014H, R 2  is \u2014H, \u2018a\u2019 is a single bond, and \u2018b\u2019 is a double bond, R 3  is C 1 -C 4  alkoxy; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 90.0
- Lexical Diversity: 1.39286
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15934643', '14440155', '14047362', '13577431', '15576101']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7435605847052227
- 35 USC 102 Novelty (BERT): 0.6028927873633017
- Combined Prediction Score: 0.7294938049710306
- Mean Citation Score: 278.273244
- Max Citation Score: 543.7681
- Similarity Product: 443.44762897995713

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test