PATENT CLAIM ANALYSIS

Application Number: 16057241
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["355", "067000"]

Abstract:
The inventive subject matter provides methods for reproducibly fabricating hydrogel-based organ and tumor models inside multi-well plates. A hydrogel precursor, which can include cells, is instilled into a well. A pillar is inserted into the well to contact the hydrogel precursor with a surface that can be shaped or textured to provide a desired surface configuration or contour, for example that of a desired organoid or tumor feature. The hydrogel precursor is polymerized and the pillar removed. A second hydrogel precursor, which can contain a different cell type, is then instilled into the well and a second pillar, which can have a different configuration or texture, inserted. Subsequent polymerization generates a second hydrogel portion within the well. Polymerization can be carried out by photopolymerization. Different wells can be aligned with different, individually controlled light sources or a single, collimated light source.

Claim (Index 3):
The method of  claim 1 , wherein the wash step comprises aspiration with phosphate buffered saline (PBS) or cell culture media.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 96.0
- Lexical Diversity: 1.95062
- Patent Class: 355.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15645979', '14575084', '14166744', '14872920', '14247951']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6969049506752063
- 35 USC 102 Novelty (BERT): 0.5077246360626582
- Combined Prediction Score: 0.6779869192139516
- Mean Citation Score: 196.003722
- Max Citation Score: 311.73364
- Similarity Product: 213.3791802160024

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test