PATENT CLAIM ANALYSIS

Application Number: 16186769
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["514", "252010"]

Abstract:
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

Claim (Index 15):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, selected from the group consisting of:\n 3-(4-(6-cyclopropylpyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(6-cyclopropyl-4-fluoropyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(6-cyclopropyl-4-methylpyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(4-Fluorophenyl)-3-(4-(4-methyl-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, 3-(4-(6-(difluoromethoxy)-2,4-dimethylpyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(6-(difluoromethoxy)-4-methylpyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, 3-[4-[6-(difluoromethoxy)-4-(hydroxymethyl)-3-pyridyl]phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-[4-[3-(2-hydroxyethyl)-5-(trifluoromethyl)-2-pyridyl]phenyl]oxetane-3-carboxamide, (R or S)\u2014N-(4-fluorophenyl)-3-(4-(4-(1-hydroxyethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, 3-[4-[6-(difluoromethoxy)-4-(1-hydroxy-1-methyl-ethyl)pyridin-1-ium-3-yl]phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide;2,2,2-trifluoroacetate, N-(4-chlorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carb oxamide, N-(4-chlorophenyl)-3-[4-[4-(hydroxymethyl)-6-(trifluoromethyl)-3-pyridyl]phenyl]oxetane-3-carboxamide, N-(4-chlorophenyl)-3-[4-[6-(difluoromethoxy)-4-(hydroxymethyl)-3-pyridyl]phenyl]oxetane-3-carboxamide, 3-[4-[6-cyclopropyl-2-(hydroxmethyl)pyridin-1-ium-3-yl]phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-[4-[2-cyclopropyl-4-(hydroxymethyl)thiazol-3-ium-5-yl]phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-[4-[6-(trifluoromethyl)pyridin-1-ium-3-yl]phenyl]oxetane-3-carboxamide, N-(4-fluorophenyl)-3-[4-[2-(hydroxymethyl)-6-(trifluoromethyl)-3-pyridyl]phenyl]oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4-(2-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, 3-(4-(4-(fluoromethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(4-(trifluoromethoxy)phenyl)oxetane-3-carboxamide, N-(4-bromophenyl)-3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, N-(6-chloropyridin-3-yl)-3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, 3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(4-(trifluoromethyl)phenyl)oxetane-3-carb oxamide, N-(3,4-difluorophenyl)-3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, N-(4-cyanophenyl)-3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, N-(6-fluoropyridin-3-yl)-3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, N-(4-(difluoromethoxy)phenyl)-3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carb oxamide, 3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(6-(trifluoromethyl)pyridin-3-yl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)oxetane-3-carboxamide, 3-(4-(5-chloro-1H-benzo[d]imidazol-2-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(6-fluoro-1H-benzo[d]imidazol-2-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(5,6-difluoro-1H-benzo[d]imidazol-2-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(6-cyano-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(6-cyclopropylpyridin-3-yl)phenyl)-N-(5-fluoropyridin-2-yl)oxetane-3-carboxamide, 3-(4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(4-cyclopropyl-6-oxopyrimidin-1(6H)-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(4-cyclopropyl-6-methyl-2-oxopyrimidin-1(2H)-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-1-(6-(2-phenyloxazol-4-yl)pyridin-3-yl)cyclobutane-1-carboxamide, 1-(6\u2032-cyclopropyl-[2,3\u2032-bipyridin]-5-yl)-N-(4-fluorophenyl)cyclobutane-1-carboxamide, 1-(6-(5-cyano-1H-indol-2-yl)pyridin-3-yl)-N-(4-fluorophenyl)cyclobutane-1-carboxamide, 1-(6-(3-cyclopropyl-1H-pyrazol-5-yl)pyridin-3-yl)-N-(4-fluorophenyl)cyclobutane-1-carboxamide, N-(4-fluorophenyl)-1-(6-(3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridin-3-yl)cyclobutane-1-carboxamide, N-(4-fluorophenyl)-1-(4\u2032-(hydroxymethyl)-6\u2032-(trifluoromethyl)-[2,3\u2032-bipyridin]-5-yl) cyclobutane-1-carboxamide, 1-(4-(4-cyclopropyl-1H-pyrazol-1-yl)phenyl)-N-propylcyclobutane-1-carboxamide, 1-(4-(2-(4-fluorophenyl)oxazol-4-yl)phenyl)-N-propylcyclobutane-1-carboxamide, 1-(4-(6-cyclopropylpyridin-3-yl)phenyl)-N-propylcyclobutane-1-carboxamide, 1-(4-(6-(4-fluorophenyl)pyridin-3-yl)phenyl)-N-propylcyclobutane-1-carboxamide, 1-(4-(6-cyclopropylpyridin-3-yl)phenyl)-N-(5-fluoropyridin-2-yl)cyclobutane-1-carboxamide, 1-(4-(6-cyclopropyl-4-fluoropyridin-3-yl)phenyl)-N-(5-fluoropyridin-2-yl)cyclobutane-1-carboxamide, 1-(4-(6-cyclopropyl-4-methylpyridin-3-yl)phenyl)-N-(5-fluoropyridin-2-yl)cyclobutane-1-carboxamide, 1-(4-(6,7-difluoro-1H-benzo[d]imidazol-2-yl)phenyl)-N-(5-fluoropyridin-2-yl)cyclobutane-1-carboxamide, 1-(4-(7-fluoro-1H-benzo[d]imidazol-2-yl)phenyl)-N-(5-fluoropyridin-2-yl)cyclobutane-1-carboxamide, 1-(4-(5-cyano-1H-benzo[d]imidazol-2-yl)phenyl)-N-(5-fluoropyridin-2-yl)cyclobutane-1-carboxamide, 1-(4-(4,7-difluoro-1H-benzo[d]imidazol-2-yl)phenyl)-N-(5-fluoropyridin-2-yl)cyclobutane-1-carboxamide, 1-(4-(4,4-difluoro-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazol-2-yl)phenyl)-N-(5-fluoropyridin-2-yl)cyclobutane-1-carboxamide, N-(4-fluorophenyl)-3-(4\u2032-(hydroxy methy)-6\u2032-(tri)-[3,3\u2032-bipyridin]-6-yl)oxetane-3-carboxamide, 3-(6\u2032-(difluoromethoxy)-4\u2032-(hydroxymethyl)-[3,3\u2032-bipyridin]-6-yl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(6\u2032-(difluoromethoxy)-4\u2032-(2-hydroxypropan-2-yl)-[3,3\u2032-bipyridin]-6-yl)-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4\u2032-(2-hydroxypropan-2-yl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)oxetane-3-carb oxamide, 3,3-difluoro-N-(4-fluorophenyl)-1-(4-(4-(hydroxymethyl)-6-(trifluoro methyl) pyridin-3-yl)phenyl)cyclobutane-1-carboxamide, N-(4-fluorophenyl)-1-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl) phenyl)cyclobutane-1-carboxamide, N-(4-fluorophenyl)-5-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)spiro[2.3]hexane-5-carboxamide, 1-(4-(4,7-difluoro-1-oxoisoindolin-2-yl)phenyl)-N-(4-fluorophenyl)cyclobutane-1-carboxamide, N-(4-fluorophenyl)-3-(4\u2032-(hydroxymethyl)-6\u2032-(trifluoromethyl)-[2,3\u2032-bipyridin]-5-yl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(6-(2-(hydroxymethyl)-4-(trifluoromethyl)phenyl)pyridin-3-yl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(6-(2-(2-hydroxypropan-2-yl)-4-(trifluoromethyl)phenyl)pyridin-3-yl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4\u2032-(2-hydroxypropan-2-yl)-6\u2032-(trifluoromethyl)-[2,3\u2032-bipyridin]-5-yl)oxetane-3-carboxamide, 3-(6\u2032-cyclopropoxy-4\u2032-(hydroxymethyl)-[2,3\u2032-bipyridin]-5-yl)-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(5-fluorothiazol-2-yl)-3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, 3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(5-(trifluoromethyl)oxazol-2-yl)oxetane-3-carboxamide, N-cyclohexyl-3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, 3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(5-(trifluoromethyl)thiazol-2-yl)oxetane-3-carboxamide, 3-(4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(4-(trifluoromethyl)oxazol-2-yl)oxetane-3-carboxamide, N-(4-fluorophenyl)-1-(4\u2032-(hydroxymethyl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)cyclobutanecarboxamide, N-(4-fluorophenyl)-1-(4\u2032-(1-hydroxycyclobutyl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)cyclobutanecarboxamide, N-(4-fluorophenyl)-1-(5-(2-(hydroxymethyl)-4-(trifluoromethyl)phenyl)pyridin-2-yl)cyclobutanecarboxamide, N-(4-fluorophenyl)-1-(4\u2032-(2-hydroxypropan-2-yl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)cyclobutanecarboxamide, N-(4-fluorophenyl)-3-(4-(3-(hydroxymethyl)-5-(trifluoromethyl)pyridin-2-yl)phenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4-(4-(1-hydroxycyclobutyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4-(4-(1-hydroxycyclopropyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, 3-(4-(6-cyclopropoxy-4-(hydroxymethyl)pyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(6-cyclopropoxy-4-(2-hydroxypropan-2-yl)pyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 5-(4-(3-((4-fluorophenyl)carbamoyl)oxetan-3-yl)phenyl)-N-methyl-2-(trifluoromethyl)isonicotinamide, 5-(4-(3-((4-fluorophenyl)carbamoyl)oxetan-3-yl)phenyl)-2-(trifluoromethyl)isonicotinamide, (R)-3-(4-(4-(1-amino-2,2,2-trifluoroethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, (S)-3-(4-(4-(1-amino-2,2,2-trifluoroethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)pyridin-2-yl)phenyl)oxetane-3-carboxamide, 3-(4-(5-cyclopropoxy-3-(hydroxymethyl)pyridin-2-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4-(5-cyclopropoxy-3-(2-hydroxypropan-2-yl)pyridin-2-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4\u2032-cyclopropoxy-2\u2032-(2-hydroxypropan-2-yl)-[1,1\u2032-biphenyl]-4-yl)-N-(4-fluorophenyl)oxetane-3-carboxamide, 3-(4\u2032-cyclopropoxy-2\u2032-(hydroxymethyl)-[1,1\u2032-biphenyl]-4-yl)-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4-(4-(hydroxymethyl)-6-isopropoxypyridin-3-yl)phenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-1-(5-(2-(hydroxymethyl)-4-(trifluoromethyl)phenyl) pyrazin-2-yl)cyclobutane-1-carboxamide, N-(4-chlorophenyl)-1-(5-(2-(hydroxymethyl)-4-(trifluoromethyl)phenyl) pyrazin-2-yl)cyclobutane-1-carboxamide, N-(6-fluoropyridin-3-yl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide, 3-(4-(6-cyclopropoxy-4-(hydroxymethyl)pyridin-3-yl)phenyl)-N-(6-fluoropyridin-3-yl)oxetane-3-carboxamide, 3-(4-(6-cyclopropoxy-4-(2-hydroxypropan-2-yl)pyridin-3-yl)phenyl)-N-(6-fluoropyridin-3-yl)oxetane-3-carboxamide, 3-fluoro-N-(4-fluorophenyl)-1-(4\u2032-(hydroxymethyl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)cyclobutanecarboxamide, 4-fluoro-N-(1-(7-hydroxy-5-(2-methylpyrimidin-4-yl)-5,6,7,8-tetrahydro-1,5-naphthyridin-2-yl)cyclopropyl)benzamide, N-(4-fluorophenyl)-3-(4-(hydroxymethyl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)oxetane-3-carboxamide, 3-(4-(6-(2,2-difluoroethoxy)-4-(hydroxymethyl)pyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(4-(4-(hydroxymethyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)phenyl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(2\u2032-(1-hydroxycyclopropyl)-4\u2032-(trifluoromethyl)-[1,1\u2032-biphenyl]-4-yl)oxetane-3-carboxamide, N-(4-fluorophenyl)-1-(2\u2032-propionyl-4\u2032-(trifluoromethyl)-[1,1\u2032-biphenyl]-4-yl)cyclobutane-1-carboxamide, N-(4-fluorophenyl)-3-(2\u2032-(hydroxymethyl)-4\u2032-(trifluoromethoxy)-[1,1\u2032-biphenyl]-4-yl)oxetane-3-carboxamide, 3-(3-fluoro-4-(4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)-N-(4-fluorophenyl)oxetane-3-carboxamide, N-(6-chloropyridin-3-yl)-3-(4\u2032-(hydroxymethyl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)oxetane-3-carboxamide, N-(4-fluorophenyl)-3-(5-(2-(hydroxymethyl)-4-(trifluoromethyl)phenyl)pyridin-2-yl)oxetane-3-carboxamide, N-(6-chloropyridin-3-yl)-3-(4\u2032-(2-hydroxypropan-2-yl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)oxetane-3-carb oxamide, N-(6-fluoropyridin-3-yl)-3-(4\u2032-(2-hydroxypropan-2-yl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)oxetane-3-carboxamide, and N-(4-chlorophenyl)-3-(4\u2032-(2-hydroxypropan-2-yl)-6\u2032-(trifluoromethyl)-[3,3\u2032-bipyridin]-6-yl)oxetane-3-carboxamide.

Metadata:
- Claim Count in Document: 34.0
- Percentile: 98.0
- Lexical Diversity: 2.08571
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16061597', '13780510', '11641284', '13501633', '11430441']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8403559548609836
- 35 USC 102 Novelty (BERT): 0.5543844952968171
- Combined Prediction Score: 0.811758808904567
- Mean Citation Score: 392.197194
- Max Citation Score: 435.63135
- Similarity Product: 334.522815352124

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test