PATENT CLAIM ANALYSIS

Application Number: 15890048
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "04400A"]

Abstract:
The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.

Claim (Index 2):
A method of inhibiting expression of B7-H1 in a tumor cell or a tumor-infiltrating leukocyte, the method comprising: (a) identifying a subject with cancer, the cancer comprising a target cell that expresses B7-H1, the target cell being a tumor cell or a tumor-infiltrating leukocyte, (b) introducing into the target cell an antisense oligonucleotide of protein nucleic acid (PNA) that hybridizes to a B7-H1 transcript, wherein the antisense oligonucleotide inhibits expression of B7-H1 in the cell, and (c) administering endostatin to said subject.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.48718
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11245713', '13012063', '15047445', '11688638', '14950748']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7208858317493443
- 35 USC 102 Novelty (BERT): 0.5508696045621028
- Combined Prediction Score: 0.7038842090306202
- Mean Citation Score: 346.832918
- Max Citation Score: 426.92935
- Similarity Product: 311.5635418835074

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test