PATENT CLAIM ANALYSIS

Application Number: 15945324
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["514", "210210"]

Abstract:
Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

Claim (Index 1):
A compound of formula 1: or a pharmaceutically acceptable salt thereof wherein\n X is C(R 6 ), Y is selected from \u2014O\u2014, \u2014S\u2014, and \u2014N(R 7 )\u2014 or Y is absent, and R 1  is heteroaryl optionally substituted with one or more groups selected from halo, \u2014CF 3 , \u2014CF 2 H, cycloalkyl, \u2014C(O)R 11 , \u2014C(O)OR 11 , \u2014ON, \u2014C(O)NR 13 R 14 , \u2014NR 13 R 14 , \u2014NR 13 C(O)R 11 , \u2014NR 13 S(O) n R 12 , \u2014NR 13 S(O) n NR 13 R 14 , \u2014NR 13 C(O)OR 12 , \u2014NR 13 C(O)NR 13 R 14 , \u2014NO 2 , \u2014S(O) n R 12 , \u2014S(O) n NR 13 R 14 , heterocycle, heteroaryl, aryl, alkenyl, alkynyl, lower alkyl, lower alkyl substituted with hydroxy, lower alkyl substituted with lower alkoxy, lower alkyl substituted with \u2014NR 13 R 14 , and lower alkyl substituted with heterocycle; \n R 2  and R 3  are independently selected from hydrogen, and alkyl, or R 2  and R 3 , together with the carbon to which they are attached, form a ring chosen from 3- to 7-membered cycloalkyl and 3- to 7-membered heterocycle; \n R 4  is selected from halo, alkyl, cycloalkyl, heterocycle, aryl and heteroaryl, each of which, except for halo, is optionally substituted with one or more groups selected from: \n lower alkyl optionally substituted with one or more groups selected from hydroxy, lower alkoxy, cyano, halo, \u2014C(O)OR 11 , \u2014C(O)NR 13 R 14 , \u2014NR 13 R 14 , \u2014OC(O)R 11 , \u2014NR 13 C(O)R 11 , \u2014NR 13 S(O) n R 12 , \u2014NR 13 S(O) n NR 13 R 14 , \u2014NR 13 C(O)OR 12 , and \u2014NR 13 C(O)NR 13 R 14 , \n lower alkoxy optionally substituted with one or more groups selected from halo, hydroxy, and lower alkoxy; \n cycloalkoxy optionally substituted with one or more groups selected from halo, hydroxy, and lower alkoxy; \n heterocycloalkoxy optionally substituted with one or more groups selected from halo, hydroxy, and lower alkoxy; \n heterocycle optionally substituted with one or more groups selected from lower alkyl, halo, hydroxy, and lower alkoxy; \n heteroaryloxy optionally substituted with one or more groups selected from lower alkyl, halo, hydroxy, and lower alkoxy; \n aryl optionally substituted with one or more groups selected from lower alkyl, halo, hydroxy, and lower alkoxy; \n heteroaryl optionally substituted with one or more groups selected from lower alkyl, halo, hydroxy, and lower alkoxy; \n halo, cyano, \u2014C(O)R 11 , \u2014C(O)OR 11 , \u2014NR 13 R 14 , \u2014NR 13 C(O)R 11 , \u2014NR 13 S(O) n R 12 , \u2014NR 13 S(O) n NR 13 R 14 , \u2014NR 13 C(O)OR 12 , \u2014NR 13 C(O)NR 13 R 14 , \u2014C(O)NR 13 R 14 , \u2014S(O) n R 12 , and \u2014S(O) n NR 13 R 14 ; \n R 5  is selected from hydrogen, halo, OH, NH 2 , CF 3 , \u2014CF 2 H, alkyl, alkenyl, and alkynyl; \n R 6  is selected from hydrogen, \u2014OH, \u2014NH 2 , \u2014NHC(O)R 11 , halo and alkyl; \n R 7  is selected from hydrogen and lower alkyl; \n each n is independently 0, 1, or 2; \n R 11 , R 12 , R 13 , and R 14  are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocycle, each of which except for hydrogen, is optionally substituted with one or more groups selected from halo, lower alkyl, hydroxy, and lower alkoxy, or R 13  and R 14 , with the nitrogen to which they are attached, combine to form a heterocycle ring, which is optionally substituted with one or more groups selected from halo, lower alkyl, hydroxy, and lower alkoxy and further optionally includes one or two additional heteroatoms in the heterocycle ring wherein the one or two additional heteroatoms are selected from \u2014O\u2014, \u2014S\u2014, and \u2014N(R 15 )\u2014; and \n R 15  is selected from hydrogen, lower alkyl, \u2014C(O)R 11 , \u2014C(O)OR 11 , \u2014C(O)NR 13 R 14 , \u2014S(O) n R 12 , and \u2014S(O) n NR 13 R 14 ; \n provided that R 1  is not optionally substituted phenyl or optionally substituted 4-pyridinyl.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 91.0
- Lexical Diversity: 1.07143
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13891961', '15454760', '13501222', '13108642', '11745921']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8011460427361241
- 35 USC 102 Novelty (BERT): 0.5600025746861284
- Combined Prediction Score: 0.7770316959311245
- Mean Citation Score: 400.447278
- Max Citation Score: 416.58853
- Similarity Product: 368.4244938455439

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test