PATENT CLAIM ANALYSIS

Application Number: 15920446
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-09
Patent Classification: ["435", "006100"]

Abstract:
The present invention relates to methods of depleting or isolating target RNA from a nucleic acid sample.

Claim (Index 1):
A method of depleting target RNA from a nucleic acid sample comprising target and non-target RNA molecules, comprising:\n (a) contacting the nucleic acid sample with a multiplicity of modified single strand DNA probes in a mixture, wherein the multiplicity of modified single strand DNA probes are complementary to part of the target RNA and capable of specifically hybridizing to 3 to 100% of entire full length sequence of the target RNA, wherein the multiplicity of single strand DNA probes are ranging from 40 to 120 bases; and (b) contacting the mixture with a matrix that specifically interacts with the multiplicity of modified single strand DNA probes on a modified DNA-RNA hybrid, such that the modified DNA-RNA hybrid bind to the matrix and are removed from the mixture, wherein the multiplicity of modified single strand DNA probes are having affinitive moiety at a ratio of at least one affinitive moiety per every 10 nucleotides and the matrix is affinitive matrix, or the multiplicity of modified single strand DNA probes are having reactive moiety at a ratio of at least one reactive moiety per every 10 nucleotides and the matrix is reactive matrix.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 90.0
- Lexical Diversity: 1.0
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12940981', '14223788', '14644455', '15688600', '14390012']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5955937549209867
- 35 USC 102 Novelty (BERT): 0.526314104508088
- Combined Prediction Score: 0.5886657898796968
- Mean Citation Score: 333.703962
- Max Citation Score: 361.99994
- Similarity Product: 296.831662689687

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test