PATENT CLAIM ANALYSIS

Application Number: 15892477
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-08
Patent Classification: ["422", "501000"]

Abstract:
An apparatus and method of using a pipette with pipette tip columns were developed in which a pipette is operated with the pipette tip columns inserted into the wells of a microplate. In this configuration the pipette is free standing and is essentially perpendicular to the microplate. The pipette is hand-held when transferring between positions, e.g., between operation steps that take place in different rows of wells. The open lower ends of the pipette tip column are approximately centered within the plate well. The columns and plate are designed in such a way that the open lower ends of the pipette tip columns are in contact with liquid in the plate well however, the columns do not seal on the well bottom, preventing flow in and out of the column. The pipette contains the appropriate firmware and software to control flow for all steps of pipette tip column operation. In some embodiments, cells are purified from biological samples.

Claim (Index 1):
An apparatus for operating pipette tip columns, comprised of:\n a) at least one well, tube or vial; b) at least one pipette tip column, wherein the pipette tip column has an open upper end, an open lower end, and a solid phase therebetween, wherein the solid phase is comprised of a functional group having an affinity for cells, wherein the pipette tip column is positioned within a well, tube or vial in such a way that the pipette tip column is approximately centered within the well, tube or vial and the open lower end of the pipette tip column does not form a seal with the bottom of the well, tube or vial that prevents liquid flow into or out of the open lower end of the pipette tip column; c) an hands-free pump, wherein the hands-free pump is comprised of firmware and software, wherein the hands-free pump is capable of pipette tip column operation, wherein the open upper end of the pipette tip column is engaged with the hands-free pump in such a way that a stand is not required to support the hands-free pump and a hand is not required to support the hands-free pump, wherein the hands-free pump will not tip over and wherein the hands-free pump is situated at an angle that is 35 degrees or less from vertical; and d) a holding apparatus, wherein the well, tube or vial is positioned within the holding apparatus, and wherein the holding apparatus has sufficient area to keep the well, tube or vial from falling over when the pipette tip column is positioned within the well, tube or vial and the pipette tip column is engaged with the hands-free pump.

Metadata:
- Claim Count in Document: 52.0
- Percentile: 88.0
- Lexical Diversity: 2.02381
- Patent Class: 422.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14846825', '13023519', '12767659', '13752227', '12914874']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.776187961673982
- 35 USC 102 Novelty (BERT): 0.5068925785974298
- Combined Prediction Score: 0.7492584233663268
- Mean Citation Score: 271.924394
- Max Citation Score: 327.6996
- Similarity Product: 316.6754640742778

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test