PATENT CLAIM ANALYSIS

Application Number: 16205489
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["530", "300000"]

Abstract:
Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.

Claim (Index 5):
The three dimensional hydrogel matrix of  claim 1 , wherein the peptide comprises RLVSYNGIIFFLK (SEQ ID NO.: 17), VLFGFLKIYSRIN (SEQ ID NO.: 18), GRGDS (SEQ ID NO.: 19), GRDGS (SEQ ID NO.: 20), WQPPRARI (SEQ ID NO.: 21), or RPQIPWAR (SEQ ID NO.: 22).

Metadata:
- Claim Count in Document: 24.0
- Percentile: 98.0
- Lexical Diversity: 1.73973
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14527028', '14353665', '16063040', '14741696', '14553442']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6405675014747992
- 35 USC 102 Novelty (BERT): 0.6810396173675332
- Combined Prediction Score: 0.6446147130640727
- Mean Citation Score: 373.50258
- Max Citation Score: 780.90546
- Similarity Product: 648.4010496888758

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test