PATENT CLAIM ANALYSIS

Application Number: 16170733
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "359000"]

Abstract:
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

Claim (Index 1):
A method for treating a subject having a disease or disorder comprising administering a therapeutically effective amount of at least one binding moiety-drug conjugate (SDC-TRAP) to the subject, thereby treating the disease or disorder, wherein the SDC-TRAPA comprises a binding moiety and an effector moiety, wherein the binding moiety binds to Hsp90 and wherein the effector moiety is a cytotoxic agent selected from the group consisting of flavopiridol, lapatinib, axitinib, vemurafenib, imatinib, staurosporine, panobinostat, carfilzomib, INCB024360 and methyl tryptophan or (a) fragment(s) thereof, and wherein the binding moiety and the effector moiety are covalently attached.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 97.0
- Lexical Diversity: 1.92982
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14510518', '15251255', '15266411', '15138785', '15222145']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8153821186713908
- 35 USC 102 Novelty (BERT): 0.5798300229523592
- Combined Prediction Score: 0.7918269090994876
- Mean Citation Score: 439.612942
- Max Citation Score: 494.67075
- Similarity Product: 424.3367105167508

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test