PATENT CLAIM ANALYSIS

Application Number: 16175261
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2020-01
Patent Classification: ["424", "001690"]

Abstract:
The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.

Claim (Index 2):
The process according to  claim 1 , comprising:\n (1) forming a complex of the radionuclide  177 Lu and a somatostatin receptor binding peptide linked to the chelating agent DOTA by\n (1.1) providing an aqueous solution comprising the radionuclide; \n (1.2) providing an aqueous solution comprising the a somatostatin receptor binding peptide linked to the chelating agent, and a first stabilizer against radiolytic degradation and optionally a second stabilizer against radiolytic degradation different from the first stabilizer; and \n (1.3) mixing the solutions provided in steps (1.1) and (1.2) and heating the resulting mixture to form a solution comprising the complex; \n (2) diluting the solution comprising the complex obtained by step (1) by\n (2.1) providing an aqueous dilution solution optionally comprising at least one stabilizer against radiolytic degradation; and \n (2.2.) mixing the solution comprising the complex obtained by step (1) with the dilution solution provided in step (2.1) to obtain the pharmaceutical aqueous solution; \n wherein if the solution in step (1.2) comprises only one stabilizer that is the first stabilizer, then the solution in step (2.1) comprise at least one stabilizer that is different from the first stabilizer.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 97.0
- Lexical Diversity: 1.30769
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16175239', '15133623', '15133726', '13264276', '10513586']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6989311402004332
- 35 USC 102 Novelty (BERT): 0.5995248588897002
- Combined Prediction Score: 0.68899051206936
- Mean Citation Score: 269.07739200000003
- Max Citation Score: 542.529
- Similarity Product: 449.83275782471895

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test