PATENT CLAIM ANALYSIS

Application Number: 15863760
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "316000"]

Abstract:
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof.

Claim (Index 1):
A compound selected from: or an enantiomer, diastereomer, stereoisomer, or a pharmaceutically acceptable salt thereof, wherein:\n R is \n each W is independently absent, CH 2 , O, S, NH or NR 5 ; R 5  is H, deuterium, C 1 -C 3  alkyl, F, or Cl; Z is absent, CH 2 , O, NH or NR 5 ; Q is absent or \u2014CH 2 C(O)NH\u2014; p1 is selected from 0, 1, 2, 3, 4, 5, and 6; p2 is selected from 0, 1, 2, 3, 4, 5, and 6; p3 is selected from 1, 2, 3, 4, and 5; Degron is selected from: Y is a bond, (CH 2 ) 1-6 , (CH 2 ) 0-6 \u2014O, (CH 2 ) 0-6 \u2014C(O)NR 2 \u2032, (CH 2 ) 0-6 \u2014NR 2 \u2032C(O), (CH 2 ) 0-6 \u2014NH, or (CH 2 ) 0-6 \u2014NR 2 ; X is C(O) or C(R 3 ) 2 ; X 1 -X 2  is C(R 3 )\u2550N or C(R 3 ) 2 \u2014C(R 3 ) 2 ; each R 1  is independently halogen, OH, C 1 -C 6  alkyl, or C 1 -C 6  alkoxy; R 2  is C 1 -C 6  alkyl, C(O)\u2014C 1 -C 6  alkyl, or C(O)\u2014C 3 -C 6  cycloalkyl; R 2 \u2032 is H or C 1 -C 6  alkyl; each R 3  is independently H or C 1 -C 3  alkyl; m is 0, 1, 2, or 3; n is 0, 1, or 2; R AR1  is selected from: R AR2  is selected from:

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.71739
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15632023', '15148262', '15148253', '14707930', '15148257']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8781251115763132
- 35 USC 102 Novelty (BERT): 0.6676617809535976
- Combined Prediction Score: 0.8570787785140417
- Mean Citation Score: 756.5789580000003
- Max Citation Score: 789.9582
- Similarity Product: 611.6374026038646

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test