PATENT CLAIM ANALYSIS

Application Number: 15869929
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["424", "133100"]

Abstract:
The present invention relates to the treatment or prevention of tinnitus. More precisely, the present invention relates to a compound modulating chloride co-transporter NKCC1 (chloride co-transporter modulator) for use in the treatment of tinnitus. In addition, the present invention concerns pharmaceutical compositions comprising such an NKCC1 chloride co-transporter modulator as an active agent, a method for the treatment or prevention of tinnitus by administering such a chloride co-transporter modulator, an a screening method for the identification and characterization of compounds capable of modulating chloride co-transporter NKCC1.

Claim (Index 9):
The method of  claim 8 , wherein diuretic compound is selected from the group consisting of\n (i) bumetanide, bumetanide aldehyde, bumetanide methyl ester, bumetanide cyanomethyl ester, bumetanide ethyl ester, bumetanide isoamyl ester, bumetanide octyl ester, bumetanide benzyl ester, bumetanide dibenzylamide, bumetanide diethylamide, bumetanide morpholinoethyl ester, bumetanide 3-(dimethylaminopropyl) ester, bumetanide N,N-diethylglycolamido ester, bumetanide N,N-dimethylglycolamido ester, bumetanide pivaxetil ester, bumetanide propaxetil ester, bumetanide methoxy(polyethyleneoxy) n-1 -ethyl ester, bumetanide benzyltrimethylammonium salt and bumetanide cetyl-trimethylammonium salt, bumetanide [-(C\u2550O)-SH] thioacid, bumetanide S-methyl thioester, bumetanide S-cyanotnethyl thioester, bumetanide S-ethyl thioester, bumetanide S-isoamyl thioester, bumetanide S-octyl thioester, bumetanide S-benzyl thioester, bumetanide S-(morpholinoethyl) thioester, bumetanide S-[3-(dimethylaminopropyl)] thioester, bumetanide S-(N,N-diethylglycolamido) thioester, bumetanide S-(N,N-dimethylglycolamido) thioester, bumetanide S-pivaxetil thioester, bumetanide S-propaxetil thioester, bumetanide S-[methoxy(polyethyleneoxy) n-1 -ethyl] thioester, bumetanide [-(C\u2550O)-S \u2212 ] benzyltrimethyl-ammonium thioacid salt and bumetanide [-(C\u2550O)-S \u2212 ] cetyltrimethylammonium thioacid salt, metastable bumetanide [-(C\u2550S)-OH] thioacid, bumetanide O-methyl thioester, bumetanide O-cyanomethyl thioester, bumetanide O-ethyl thioester, bumetanide O-isoamyl thioester, bumetanide O-octyl thioester, bumetanide O-benzyl thioester, bumetanide O-(morpholinoethyl) thioester, bumetanide O-[3-(dimethylaminopropyl)] thioester, bumetanide O-(N,N-diethylglycolamido) thioester, bumetanide, O-(N,N-dimethylglycolamido) thioester, bumetanide O-pivaxetil thioester, bumetanide O-propaxetil thioester, bumetanide O-[methoxy(poryethyleneoxy) n-1 -ethyl] thioester, bumetanide [-(C\u2550S)-O \u2212 ] benzyltrimemyl-ammonium thioacid salt and bumetanide [-(C\u2550S)-O \u2212 ] cetyltrimethylammonium thioacid salt, bumetanide thioaldehyde, bumetanide [-(C\u2550S)-SH] dithioacid, bumetanide methyl dithioester, bumetanide cyanomethyl dithioester, bumetanide ethyl dithioester, bumetanide isoamyl dithioester, bumetanide octyl dithioester, bumetanide benzyl dithioester, bumetanide dibenzylthioamide, bumetanide diethylthioamide, bumetanide morpholinoethyl dithioester, bumetanide 3-(dimethylaminopropyl) dithioester, bumetanide N,N-diethylglycolamido dithioester, bumetanide N,N-dimethylglycolamido dithioester, bumetanide pivaxetil dithioester, bumetanide propaxetil dithioester, bumetanide methoxy(polyethyleneoxy) n-1 -ethyl dithioester, bumetanide benzyltrimethylammonium dithioacid salt and bumetanide cetyltrimethyl-ammonium dithioacid salt and (ii) furosemide, furosemide aldehyde, furosemide methyl ester, furosemide cyanomethyl ester, furosemide ethyl ester, furosemide isoamyl ester, furosemide octyl ester, furosemide benzyl ester, furosemide morpholinoethyl ester, furosemide 3-(dimethylaminopropyl) ester, furosemide N,N-diethylglycolamido ester, furosemide N,N-dimethylglycolamido ester, furosemide pivaxetil ester, furosemide propaxetil ester, furosemide methoxy(polyethyleneoxy) n-1 -ethyl ester, furosemide benzyltrimethylammonium acid salt and furosemide cetyltrimethylammonium acid salt and (iii) piretanide, piretanide aldehyde piretanide methyl ester, piretanide cyanomethyl ester, piretanide ethyl ester, piretanide isoamyl ester, piretanide octyl ester, piretanide benzyl ester, piretanide dibenzylamide, piretanide diethylamide, piretanide morpholinoethyl ester, piretanide 3-(dimethylaminopropyl) ester, piretanide N,N-diethylglycolamide ester, piretanide dimethylglycolamide ester, piretanide pivaxetil ester, piretanide propaxetil ester, piretanide methoxy(polyethyleneoxy) n-1 -ethyl ester, piretanide benzyltrimethylammonium salt and piretanide cetyltrimethylammonium salt and (iv) tetrazolyl-substituted azosemides, in particular methoxymethyl tetrazolyl-substituted azosemides, methylthiomethyl tetrazolyl-substituted azosemides and N-mPEG350-tetrazolyl-substituted azosemides), azosemide benzyltrimethylammonium salt and/or azosemide cetyl-trimethylammonium salt and (v) pyridine-substituted torsemide quaternary ammonium salts or the corresponding inner salts (zwitterions), in particular methoxymethyl pyridinium torsemide salts, methylthiomethyl pyridinium torsemide salts and N-mPEG350-pyridinium torsemide salts.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 2.02128
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14443154', '14087244', '13380921', '14894621', '11251724']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7838751002619697
- 35 USC 102 Novelty (BERT): 0.5561563253903654
- Combined Prediction Score: 0.7611032227748094
- Mean Citation Score: 308.9860060000001
- Max Citation Score: 461.20798
- Similarity Product: 339.23374369025464

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test