PATENT CLAIM ANALYSIS

Application Number: 15906163
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-12
Patent Classification: ["514", "230200"]

Abstract:
The present invention relates to tricyclic heterocycles of Formula (I): which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

Claim (Index 5):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein:\n  represents a double bond; L is O; Cy 1  is a five membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, wherein said five membered heteroaryl of Cy 1  is optionally substituted with 1, 2, or 3 groups independently selected from R 11 ; R 1  is selected from H, F, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, OR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , and C(\u2550O)OR a1 ; R 2  is selected from H, F, and C 1-6  alkyl; Cy 3  is selected from phenyl, C 3-7  cycloalkyl, a 5-10 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, and a 4-10 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said phenyl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of Cy 3  is optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 ; additionally, wherein a ring-forming nitrogen atom of said 5-10 membered heteroaryl group or a ring-forming nitrogen atom of said 4-10 membered heterocycloalkyl group is optionally oxidized; R 4  is H or C 1-6  alkyl; R 5  is selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, NR 15a R 15b , phenyl, C 3-7  cycloalkyl, 5-6 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, and a 4-7 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said alkyl, phenyl, C 3-7  cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl of R 5  is optionally substituted by 1, 2, 3, or 4 groups independently selected from R 15 ; R 6  is absent; R 7  is selected from H, halo, CN, C 1-6  alkyl, C 1-6  alkoxy, phenyl, and 5-6 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, wherein said alkyl, phenyl, or 5-6 membered heteroaryl group, of R 7  are optionally substituted with 1, 2, or 3 groups independently selected from R 17 ; R 8  is selected from H, halo, CN, OH, and C 1-6  alkyl; R 11  is independently at each occurrence selected from H, C 1-3  alkyl, C 1-3  haloalkyl, halo, CN, OR a , NR c R d , SR b , and C(\u2550O)NR c R d ; R 13  is independently at each occurrence selected from H, halo, CN, OH, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, OR a3 , SR a3 , C(\u2550O)R b3 , C(\u2550O)NR c3 R d3 , C(\u2550O)OR a3 , OC(\u2550O)R b3 , OC(\u2550O)NR c3 R d3 , NR c3 R d3 , NR c3 C(\u2550O)R b3 , NR c3 C(\u2550O)NR c3 R d3 , NR c3 C(\u2550O)OR a3 , S(\u2550O)R b3 , S(\u2550O)NR c3 R d3 , S(\u2550O) 2 R b3 , NR c3 S(\u2550O) 2 R b3  and S(\u2550O) 2 NR c3 R d3 , wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl of R 13  is optionally substituted with 1, 2, or 3 groups independently selected from halo, CN, OH, OR a3 , SR a3 , C(\u2550O)R b3 , C(\u2550O)NR c3 R d3 , C(\u2550O)OR a3 , OC(\u2550O)R b3 , OC(\u2550O)NR c3 R d3 , NR c3 R d3  NR c3 C(\u2550O)R b3 , NR c3 C(\u2550O)NR c3 R d3 , NR c3 C(\u2550O)OR a3 , S(\u2550O)R b3 , S(\u2550O)NR c3 R d3 , S(\u2550O) 2 R b3 , NR c3 S(\u2550O) 2 R b3  and S(\u2550O) 2 NR c3 R d3 ; R 15  is independently at each occurrence selected from H, halo, CN, OH, OR a5 , C(\u2550O)R b5 , C(\u2550O)NR c5 R d5 , C(\u2550O)OR a5 , NR c5 R d5 , and NR c5 C(\u2550O)R b5 ; R 15a  and R 15b  are independently selected from H and C 1-6  alkyl, wherein said alkyl of R 15a  and R 15b  is optionally substituted with 0, 1, 2, or 3 substituents selected from R 20 ; R 17  is independently at each occurrence selected from halo, CN, OR a , NR c R d SR b , and C(\u2550O)NR c R d ; R a , R c , and R d  are independently at each occurrence selected from H and C 1-6  alkyl; R b  is at each occurrence C 1-6  alkyl; R a1 , R b1 , R c1  and R d1  are independently at each occurrence selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl, wherein said C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl forming R a1 , R b1 , R c1  and R d1  are each optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ; R a3 , R b3 , R c3  and R d3  are independently at each occurrence selected from H and C 1-6  alkyl, wherein said C 1-6  alkyl forming R a3 , R b3 , R c3  and R d3  is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, OR a4 , SR a4 , C(\u2550O)R b4 , C(\u2550O)NR c4 R d4 , C(\u2550O)OR a4 , OC(\u2550O)R b4 , OC(\u2550O)NR c4 R d4 , NR c4 R d4  NR c4 C(\u2550O)R b4 , NR c4 C(\u2550O)NR c4 R d4 , NR c4 C(\u2550O)OR a4 , S(\u2550O)R b4 , S(\u2550O)NR c4 R d4 , S(\u2550O) 2 R b4 , NR c4 S(\u2550O) 2 R b4  and S(\u2550O) 2 NR c4 R d4 ; R a4 , R b4 , R c4  and R d4  are independently at each occurrence selected from H and C 1-6  alkyl, wherein said C 1-6  alkyl forming R a4 , R b4 , R c4  and R d4  is optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ; R a5 , R b5 , R c5  and R d5  are independently at each occurrence selected from H and C 1-6  alkyl, wherein said C 1-6  alkyl forming R a5 , R b5 , R c5  and R d5  is optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ; R 20  is at each occurrence independently selected from H, halo, OH, CN, amino, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  alkylthio, C 1-4  alkylamino, di(C 1-4  alkyl)amino, C 1-4  haloalkyl, C 1-4  haloalkoxy, C 1-4  alkyl-C(\u2550O)\u2014, C 1-4  alkyl-C(\u2550O)O\u2014, C 1-4  alkyl-OC(\u2550O)\u2014, HOC(\u2550O)\u2014, H 2 NC(\u2550O)\u2014, C 1-4  alkyl-NHC(\u2550O)\u2014, di(C 1-4  alkyl)NC(\u2550O)\u2014, C 1-4  alkyl-C(\u2550O)NH\u2014, C 1-4  alkyl-S(\u2550O)\u2014, H 2 NS(\u2550O)\u2014, C 1-4  alkyl-NHS(\u2550O)\u2014, di(C 1-4  alkyl)NS(\u2550O)\u2014, C 1-4  alkyl-S(\u2550O) 2 \u2014, C 1-4  alkyl-S(\u2550O) 2 NH\u2014, H 2 NS(\u2550O) 2 \u2014, C 1-4  alkyl-NHS(\u2550O) 2 \u2014, and di(C 1-4  alkyl)NS(\u2550O) 2 \u2014.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.24242
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15398907', '14852958', '14923105', '14212721', '15356002']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8482955361166815
- 35 USC 102 Novelty (BERT): 0.6710985216389215
- Combined Prediction Score: 0.8305758346689056
- Mean Citation Score: 617.0727119999998
- Max Citation Score: 685.05786
- Similarity Product: 660.6962960532045

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test