PATENT CLAIM ANALYSIS

Application Number: 15953168
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-12
Patent Classification: ["514", "179000"]

Abstract:
The present invention provides compounds of Formula (I) or (II), which are thought to be able to inhibit mTOR (mammalian target of rapamycin) signaling pathway, induce UPR (unfolded protein response), and/or perturb mitochondrial function of a cyst cell (e.g., a cyst cell causing polycystic kidney disease (PKD, e.g., autosomal dominant PKD (ADPKD) or autosomal recessive PKD (ARPKD)) or polycystic liver disease (PLD, e.g., autosomal dominant PLD (ADPLD) or autosomal recessive PLD (ARPLD)). The invention also provides pharmaceutical compositions, kits, and methods involving the compounds described herein for use in treating PKD or PLD, inhibiting the growth of a cyst cell, and/or killing a cyst cell.

Claim (Index 37):
A pharmaceutical composition comprising:\n a compound of Formula (I) or (II): or a pharmaceutically acceptable salt thereof; and\n optionally a pharmaceutically acceptable excipient, wherein: \n Ring A is substituted or unsubstituted phenyl or naphthyl, or substituted or unsubstituted, monocyclic or bicyclic heteroaryl, wherein one, two, three, or four atoms in the heteroaryl ring system are independently selected from the group consisting of nitrogen, oxygen, and sulfur; \n each instance of R A  is independently hydrogen, halogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014OR A1 , \u2014N(R A1 ) 2 , \u2014SR A1 , \u2014CN, \u2014SCN, \u2014C(\u2550NR A1 )R A1 , \u2014C(\u2550NR A1 )OR A1 , \u2014C(\u2550NR A1 )N(R A1 ) 2 , \u2014C(\u2550O)R A1 , \u2014C(\u2550O)OR A1 , \u2014C(\u2550O)N(R A1 ) 2 , \u2014NO 2 , \u2014NR A1 C(\u2550O)R A1 , \u2014NR A1 C(\u2550O)OR A1 , \u2014NR A1 C(\u2550O)N(R A1 ) 2 , \u2014OC(\u2550O)R A1 , \u2014OC(\u2550O)OR A1 , \u2014OC(\u2550O)N(R A1 ) 2 , or a nitrogen protecting group when attached to a nitrogen atom, or optionally two R A  groups are joined to form a substituted or unsubstituted carbocyclic, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl ring; \n each instance of R A1  is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or optionally two R A1  groups are joined to form a substituted or unsubstituted heterocyclic ring; \n k is 0, 1, 2, 3, 4, or 5; \n L is a linker stable under intracellular conditions; \n one instance of   is a double bond; \n the other instance of   is a single or double bond; \n each instance of R B  is independently hydrogen, halogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014OR B1 , \u2014N(R B1 ) 2 , \u2014SR B1 , \u2014CN, \u2014SCN, \u2014C(\u2550NR B1 )R B1 , \u2014C(\u2550NR B1 )OR B1 , \u2014C(\u2550NR B1 )N(R B1 ) 2 , \u2014C(\u2550O)R B1 , \u2014C(\u2550O)OR B1 , \u2014C(\u2550O)N(R B1 ) 2 , \u2014NO 2 , \u2014NR B1 C(\u2550O)R B1 , \u2014NR B1 C(\u2550O)OR B1 , \u2014NR B1 C(\u2550O)N(R B1 ) 2 , \u2014OC(\u2550O)R B1 , \u2014OC(\u2550O)OR B1 , \u2014OC(\u2550O)N(R B1 ) 2 , or a nitrogen protecting group when attached to a nitrogen atom, or optionally two R B  groups are joined to form a substituted or unsubstituted carbocyclic, substituted or unsubstituted heterocyclic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl ring; \n each instance of R B1  is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or optionally two R B1  groups are joined to form a substituted or unsubstituted heterocyclic ring; \n each instance of R C , R D , and R E  is independently hydrogen, halogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014OR  C1 , \u2014N(R C1 ) 2 , \u2014SR  C1 , \u2014CN, \u2014SCN, \u2014C(\u2550NR C1 )R C1 , \u2014C(\u2550NR C1 )OR C1 , \u2014C(\u2550NR C1 )N(R C1 ) 2 , \u2014C(\u2550O)R C1 , \u2014C(\u2550O)OR C1 , \u2014C(\u2550O)N(R C1 ) 2 , \u2014NO 2 , \u2014NR C1 C(\u2550O)R C1 , \u2014NR C1 C(\u2550O)OR C1 , \u2014NR C1 C(\u2550O)N(R C1 ) 2 , \u2014OC(\u2550O)R C1 , \u2014OC(\u2550O)OR C1 , \u2014OC(\u2550O)N(R C1 ) 2 , or a nitrogen protecting group when attached to a nitrogen atom; \n each instance of R C1  is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or optionally two R C1  groups are joined to form a substituted or unsubstituted heterocyclic ring; \n optionally R C  and R D  are joined to form a substituted or unsubstituted, monocyclic carbocyclic ring; and \n optionally R D  and R E  are joined to form a substituted or unsubstituted, monocyclic or bicyclic carbocyclic ring; \n provided the compound is not a compound of the formula: \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 91.0
- Lexical Diversity: 1.97183
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14515441', '14907339', '14435790', '14301653', '15737683']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7911991965218175
- 35 USC 102 Novelty (BERT): 0.5740463551233831
- Combined Prediction Score: 0.7694839123819741
- Mean Citation Score: 424.9461539999999
- Max Citation Score: 472.8585
- Similarity Product: 418.4584886454642

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test