PATENT CLAIM ANALYSIS

Application Number: 15890269
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["424", "450000"]

Abstract:
A method is presented for screening cells that produce allogeneic autophagosome enriched compositions able to induce expression of a selective marker on a subpopulation of peripheral blood mononuclear cells, the method comprising contacting a cell with a proteasome inhibitor, contacting the cell with a lysosome inhibitor, harvesting the resulting autophagosomes, determining a molecular signature of the harvested autophagosomes, and selecting cells that divert one or more Toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes. By screening for cells that divert one or more Toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes, enriched populations of autophagosomes may be generated which may illicit a specific immune response against numerous cancer types. In this way, an allogeneic, off-the-shelf cancer vaccine may be produced and made available to be administered in order to stimulate a targeted immune response in patients bearing different tumor types.

Claim (Index 13):
The method of  claim 11 , wherein the immunotherapeutic is one or more of GM-CSF, Flt3, alum, and/or CpG.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 88.0
- Lexical Diversity: 1.87209
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14061135', '14512322', '11997294', '12271576', '14974357']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7168358377179801
- 35 USC 102 Novelty (BERT): 0.67930122693729
- Combined Prediction Score: 0.7130823766399111
- Mean Citation Score: 389.1265560000001
- Max Citation Score: 767.65857
- Similarity Product: 631.0904049055481

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test