PATENT CLAIM ANALYSIS

Application Number: 16175758
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["800", "021000"]

Abstract:
A genetically modified mouse is provided that comprises a conditional Acvr1 allele that comprises a mutated exon that, upon induction, converts to a mutant exon phenotype, wherein the mutant exon phenotype includes ectopic bone formation. Mice comprising a mutant Acvr1 exon 5 in antisense orientation, flanked by site-specific recombinase recognition sites, are provided, wherein the mice further comprise a site-specific recombinase that recognizes the site-specific recombinase recognitions sites, wherein the recombinase is induced upon exposure of the mouse to tamoxifen. Upon exposure to tamoxifen, the recombinase is expressed and acts on the RRS-flanked mutant exon 5 and places the mutant exon 5 in sense orientation and deletes the wild-type exon.

Claim (Index 14):
The method according to  claim 11 , wherein the inducible recombinase is expressed in a cell in the progeny mouse comprising the modified mouse Acvr1 gene.

Metadata:
- Claim Count in Document: 75.0
- Percentile: 97.0
- Lexical Diversity: 2.01667
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14207320', '15983743', '16175762', '15336603', '09853033']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.835212343681406
- 35 USC 102 Novelty (BERT): 0.7284238783797471
- Combined Prediction Score: 0.82453349715124
- Mean Citation Score: 955.718586
- Max Citation Score: 1115.7084
- Similarity Product: 832.2703768415449

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test