PATENT CLAIM ANALYSIS

Application Number: 16055525
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-11
Patent Classification: ["435", "199000"]

Abstract:
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

Claim (Index 1):
An artificial nuclease comprising:\n (i) a DNA-binding domain that binds to a target site in the genome of the cell; and (ii) a polypeptide comprising an engineered FokI cleavage half-domain having at mutations at least two of the following positions: 483, 486, 487, 490, 496, 499, 537 or 538, numbered relative to a wild-type FokI sequence.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 96.0
- Lexical Diversity: 1.71875
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15660072', '14146471', '15160571', '14627812', '13341537']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7112900636842279
- 35 USC 102 Novelty (BERT): 0.6183242174910135
- Combined Prediction Score: 0.7019934790649064
- Mean Citation Score: 597.855348
- Max Citation Score: 602.3968
- Similarity Product: 506.99247910842894

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test