PATENT CLAIM ANALYSIS

Application Number: 15899171
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "299000"]

Abstract:
Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.

Claim (Index 1):
A compound of Formula IV: wherein:\n R5 is hydrogen, C 1  to C 6  alkoxy or halogen; \n R8 is hydrogen or R- or S-carboxylic acid or C(O)OR12 or C(O)N(H)SO 2 X; \n R9 is hydrogen or R- or S-carboxylic acid or C(O)OR12 or C(O)N(H)SO 2 X; \n the ring to which R8 or R9 are bound is cyclopentyl or cyclohexyl; \n R10 is present in two, three, four, or five positions in the phenyl ring and each instance is independently selected from the group consisting of hydrogen, halogen, nitro, C 1  to C 6  alkyl, singly or multiply halogen substituted C 1  to C 6  alkyl, C 1  to C 6  alkoxy, amino, and hydroxy; and \n m and n are each individually 0 or 1.

Metadata:
- Claim Count in Document: 49.0
- Percentile: 88.0
- Lexical Diversity: 1.53061
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15132937', '14352421', '14050937', '14993742', '12814143']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8028529998734593
- 35 USC 102 Novelty (BERT): 0.5706850176839804
- Combined Prediction Score: 0.7796362016545114
- Mean Citation Score: 393.9255059999999
- Max Citation Score: 546.6968400000002
- Similarity Product: 319.9714114503623

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test