PATENT CLAIM ANALYSIS

Application Number: 15925517
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "210180"]

Abstract:
This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.

Claim (Index 1):
A compound represented by: wherein T is CX 3  or X is selected independently, for each occurrence, from H, F, Cl or Br; wherein at least three occurrences of X are F; V is O or NR a ; R V  is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3-6 cycloalkyl, phenyl, heteroaryl, and heterocyclyl, or when R a  and R v  occur together with the nitrogen to which they are attached, form a 4-6 membered heterocyclic ring which may have an additional heteroatom selected from O, S, or N; wherein C 1 -C 6 alkyl, C 2 -C 6 alkenyl, phenyl, heterocyclic ring and heterocyclyl are optionally substituted by one, two, or three moieties independently selected from the group consisting of halogen, hydroxyl, C 1 -C 6 alkyl, cyano, phenyl; and wherein a) R 1  and R 2  taken together with the nitrogen to which they are attached form a moiety selected from: a 4-7 membered heterocyclic ring B having an additional nitrogen; or a 4-7 membered heterocyclic ring A;\n wherein one carbon of ring A has a substituent represented by: \n L 2  is C 1 -C 6 alkylene or C 1 -C 6 alkylene-NR a \u2014; R 3  and R 5  are each independently selected from phenyl, naphthyl, a mono or bicyclic heteroaryl and a mono or bicyclic heterocycle, wherein the heterocycle or heteroaryl has 1, 2 or 3 heteroatoms independently selected from O, S, or N; and wherein R 3  and R 5  may be independently and optionally substituted by one, two, three or four moieties each independently selected from R g ; R 4  is selected from the group consisting of H, halogen, hydroxyl, cyano, or C 1 -C 5 alkoxy; A is optionally substituted on another carbon by one, two, three or four substituents each independently selected from R d ; the additional nitrogen of ring B has a substituent represented by: L 3  is selected from the group consisting of: a bond, C 1 -C 6 alkylene, \u2014C(O)\u2014, C 1 -C 6 alkylene-C(O)\u2014, C(O)\u2014C 1 -C 6 alkylene-, NR a \u2014C(O)\u2014C 1 -C 6 alkylene-, C 1 -C 6 alkylene-O\u2014C(O)\u2014, \u2014S(O) w \u2014, and C 1 -C 6 alkylene-S(O) w \u2014, wherein w is 0, 1, or 2, and wherein C 1 -C 6 alkylene is optionally substituted by one or two substituents selected from the group consisting of: halogen, hydroxyl, cyano, and an additional R 7 , wherein when L 3  is \u2014S(O) w \u2014, then R 7  is not H; R 7  is selected from the group consisting of: H, phenyl, naphthyl, mono or bicyclic heteroaryl, and mono or bicyclic heterocyclyl, wherein the heteroaryl or the heterocyclyl has 1, 2 or 3 heteroatoms independently selected from O, S, or N; wherein R 7  is optionally substituted by one, two, three or four moieties independently selected from R h ; B is optionally substituted on one or more carbons by one, two, three or four moieties each independently selected from R d ; or b)\n R 1  is -L 1 -R 6 ; \n R 2  is H or C 1 -C 6 alkyl; \n L 1  is C 1 -C 6 alkylene or a bond; \n R 6  is selected from the group consisting of phenyl, naphthyl, a mono or bicyclic heteroaryl, and a mono or bicyclic heterocycle, wherein the heteroaryl or heterocycle has 1, 2 or 3 heteroatoms independently selected from O, S, or N; and R 6  is optionally substituted by one, two, three or four moieties independently selected from the group consisting of: halogen, phenyl (optionally substituted by one, two or three moieties independently selected from R c ), phenyloxy (optionally substituted by one, two or three moieties independently selected from R c ), anilinyl (optionally substituted on a carbon by one, two or three moieties independently selected from R c ), hydroxyl, cyano, C 1-6 alkyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl), C 1-6 alkoxy (optionally substituted by one, two or three halogens, cyano, or hydroxyl), R a R b N\u2014, R a R b N\u2014SO 2 \u2014, R a R b N\u2014C(O)\u2014, C 1-6 alkyl-C(O)NR a \u2014, R a \u2014S(O) w \u2014, R a \u2014S(O) w \u2014NR b \u2014 (wherein w is 0, 1 or 2), heteroaryl (optionally substituted by one, two or three moieties independently selected from R c ), or heteroaryloxy;\n R a  and R b  may be independently selected, for each occurrence, from the group consisting of hydrogen and C 1-3 alkyl; wherein C 1-3 alkyl may optionally be substituted by one or more substituents selected from halogen, cyano, oxo, hydroxyl, heterocycle, and phenyl; \n or R a  and R b , when they occur together with the nitrogen to which they are attached, form a 4-6 membered heterocyclic ring or a 9-10 membered bicyclic heterocycle or spirocyclic ring, which may have an additional heteroatom selected from O, S, or N; wherein the 4-6 membered heterocyclic ring or 9-10 membered bicyclic heterocycle or spirocycle may optionally be substituted by one or more substituents selected from the group consisting of halogen, cyano, oxo, C 1-6 alkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), hydroxyl, \u2014C(O)\u2014C 1-6 alkyl, \u2014NH 2 , and \u2014NH\u2014C(O)\u2014C 1-6 alkyl; \n R c  is selected from the group consisting of halogen, cyano, hydroxyl, nitro, C 1-6 alkyl (optionally substituted by one, two, or three halogens, cyano, or hydroxyl), C 2-6 alkenyl (optionally substituted by one, two, or three halogens), C 2-6 alkynyl (optionally substituted by one, two, or three halogens), C 3-6 cycloalkyl, C 1-6 alkoxy (optionally substituted by one, two, or three halogens), R a R b N\u2014, R a R b N\u2014SO 2 \u2014, R a R b N\u2014C(O)\u2014, R a \u2014C(O)\u2014NR a \u2014, R a \u2014C(O)\u2014, R a \u2014S(O) w \u2014NR b \u2014 (wherein w is 0, 1 or 2), or R a \u2014S(O) w \u2014 (wherein w is 0, 1 or 2); \n R d  is selected from the group consisting of: H, C 1-6 alkyl (optionally substituted by one, two or three halogens, or hydroxyl) or R a R b N\u2014C(O)\u2014; \n R g  is selected from the group consisting of: halogen, phenyl, phenyloxy, anilinyl, hydroxyl, cyano, C 1-6 alkyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl), C 3-6 cycloalkyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl), C 2-6 alkenyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl), C 2-6 alkynyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl) C 1-6 alkoxy (optionally substituted by one, two or three halogens, cyano, or hydroxyl), R a \u2014C(O)NR a \u2014, R a R b N\u2014, R a R b N\u2014SO 2 \u2014, R a \u2014S(O) w \u2014 (wherein w is 0, 1 or 2), R a \u2014SO 2 \u2014NR b \u2014, R a R b N\u2014C(O)\u2014, heterocycle (optionally substituted by one, two or three moieties each independently selected from R c , and connected to R 3  or R 5  through a carbon or heteroatom) or heteroaryl (optionally substituted by one, two or three moieties each independently selected from R c , and connected to R 3  or R 5  through a carbon or heteroatom), or two adjacent R g  groups along with the carbons to which they are attached can be taken together to form a 5- or 6-member heterocyclic or heteroaryl ring optionally substituted with 0, 1 or 2 halogens selected from F or Cl and which may have one or two additional heteroatoms selected from O, S, or N; \n R h  is selected from the group consisting of: halogen, phenyl (optionally substituted by one, two, or three moieties each independently selected from R c ), phenyloxy (optionally substituted by one, two, or three moieties each independently selected from R c ), hydroxyl, cyano, C 1-6 alkyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl), C 2-6 alkenyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl), C 2-6 alkynyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl), C 1-6 alkoxy (optionally substituted by one, two or three halogens, cyano, or hydroxyl), R a R b N\u2014, R a \u2014C(O)NR a \u2014, R a R b N\u2014SO 2 \u2014, R a R b N\u2014C(O)\u2014, R a \u2014S(O) w \u2014 (wherein w is 0, 1 or 2), R a \u2014SO 2 \u2014NR b \u2014, heteroaryl (optionally substituted by one, two or three moieties each independently selected from R c , and connected to R 7  through a carbon or heteroatom), heterocycle (optionally substituted by one, two or three moieties each independently selected from R c , and connected to R 7  through a carbon or heteroatom) or heteroaryloxy (optionally substituted by one, two, or three moieties each independently selected from R c ), or two adjacent R h  groups along with the carbons to which they are attached can be taken together to form a 5- or 6-member heterocyclic or heteroaryl ring optionally substituted with 0, 1 or 2 halogens selected from F or Cl and which may have one or two additional heteroatoms selected from O, S, or N; \n \n and pharmaceutically acceptable salts or stereoisomers thereof.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 90.0
- Lexical Diversity: 1.32203
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14599105', '14369982', '15272313', '14902324', '14383076']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8423035443513297
- 35 USC 102 Novelty (BERT): 0.5516885112361647
- Combined Prediction Score: 0.8132420410398132
- Mean Citation Score: 391.818716
- Max Citation Score: 428.7739
- Similarity Product: 340.3826481000662

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test