PATENT CLAIM ANALYSIS

Application Number: 16301027
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["514", "254030"]

Abstract:
Provided are a preparation method for a crystalline form of the compound represented by formula (A), as well as a method for preparation thereof, a composition thereof, and an application thereof in preparing an angiotensin II receptor antagonist or an application in preparing a drug for preventing and/or treating hypertension, chronic heart failure and diabetic nephropathy.

Claim (Index 11):
The preparation method of the crystalline form according to  claim 2 , wherein a preparation method of the crystalline form I comprises one or more of the following proceedings:\n (1) adding a solvent to the compound of formula (A) to obtain a suspension, and then stirring to obtain the crystalline form I; preferably, the solvent is one or more selected from a mixture of ethanol and isopropyl ether, a mixture of ethanol and n-heptane, a mixture of isopropanol and n-heptane, and a mixture of tetrahydrofuran and n-heptane; more preferably, the volume ratio of the two solvents in the mixture is from 1:8 to 8:1, and most preferably from 1:5 to 5:1; preferably, the suspension is stirred at room temperature for 0.5 to 3 days, most preferably, the suspension is stirred at room temperature for 1-2 days; (2) dissolving the compound of formula (A) into a good solvent to obtain a clear solution, and adding an anti-solvent while stirring to obtain the crystalline form I; preferably, the good solvent is one or more selected from the group consisting of methanol, ethanol and n-butanol, and the anti-solvent is one or more selected from the group consisting of isopropyl ether, methyl tert-butyl ether and methyl cyclohexane; (3) dissolving the compound of formula (A) in a solvent under heating to obtain a clear solution, and cooling the solution to obtain the crystalline form I; preferably, the solvent is selected from a mixture of ethanol and isopropyl ether, a mixture of ethanol and ethyl acetate, a mixture of ethanol and methyl tert-butyl ether, a mixture of ethanol and n-heptane, a mixture of ethanol and methylcyclohexane, or a mixture of n-butanol and n-heptane; more preferably, the volume ratio of the two solvents in the mixture is from 1:8 to 8:1, and most preferably from 1:5 to 5:1; preferably, the heating temperature is from 40\u00b0 C. to 90\u00b0 C., and most preferably from 50\u00b0 C. to 70\u00b0 C.; (4) placing the compound of formula (A) in a solvent atmosphere of ethanol for 1-3 days to obtain the crystalline form I; and (5) adding the crystalline form III and/or the crystalline form IV of the compound of formula (A) into a solvent to form a suspension, stirring and drying to obtain the crystalline form I; preferably, the solvent is selected from an ester solvent such as ethyl acetate, isopropyl acetate or a mixture thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 98.0
- Lexical Diversity: 1.46512
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13001715', '15740719', '13805920', '14116099', '13505360']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8036270605396243
- 35 USC 102 Novelty (BERT): 0.5324398304351943
- Combined Prediction Score: 0.7765083375291812
- Mean Citation Score: 333.132024
- Max Citation Score: 349.10037
- Similarity Product: 272.9745387273645

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test