PATENT CLAIM ANALYSIS

Application Number: 15768396
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["424", "009600"]

Abstract:
The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

Claim (Index 63):
(i) A compound of Formula IV: wherein: X is O or NR 43 ; R 41  is H, hydroxyl, alkoxy, -linker-lipid or polyethylene glycol; R 42  is H, alkyl, cyclyl, heterocyclyl, aryl or heteroaryl; R 43  is H, alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, and wherein in R 41 , R 42  and R 43  can be optionally substituted; (ii) a compound of Formula IV\u2032: (iii) a compound of Formula V: wherein: Y is O, S or NR 53 ; Z is O or NR 53 ; R 51  is H, alkoxy, optionally substituted alkylamino, optionally substituted alkylthio, -linker-carbohydrate, -linker-(anti-cancer agent) or -linker-lipid; R 52  is H, alkyl, cyclyl, heterocyclyl, aryl, heteroaryl, optionally substituted PEG, -linker-carbohydrate, -linker-(anti-cancer agent), -linker-NH(CH 2 CO 2 H) 2 , -linker-CO 2 H, or -linker-lipid; and\n each R 53  is same or different and selected independently from the group consisting of alkyl, cyclyl, heterocyclyl, aryl, heteroaryl, or -linker-lipid, \n provided that at least one of R 51  and R 52  is -linker-lipid, -linker-(anti-cancer agent), or -linker-carbohydrate, or R 52  is optionally substituted PEG, -linker-NH(CH 2 CO 2 H) 2 , -linker-CO 2 H, \n and\n wherein in R 51 , R 52  and R 53  can be optionally substituted; \n (iv) a compound of Formula V\u2032: (v) a compound of Formula V\u2033: wherein: each X is same or different and selected independently from the group consisting of O, N, S, NH and NR; each R\u2032 is same or different and selected independently from the group consisting of H, alkyl, cyclyl, heterocyclyl, aryl and heteroaryl; R is alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, and wherein in R and R can be optionally substituted; (vi) a compound of Formula V\u2033-B: wherein: Z is -E-linker-(anti-cancer agent) or -E-linker-carbohydrate; E is O, NH or S; each X is same or different and selected independently from the group consisting of O, N, S, NH and NR; each R\u2032 is same or different and selected independently from the group consisting of H, alkyl, cyclyl, heterocyclyl, aryl and heteroaryl, each of which can be optionally substituted; and R is alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, each of which can be optionally substituted; (vii) a compound is of Formula V\u2032\u2033: wherein: E is NH or S; X is O or NR; and R is H, alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, each of which can be optionally substituted; or (viii) a compound of Formula V\u2032\u2033-B: wherein: E is NH or S; R\u2032 is optionally substituted PEG, -linker-carbohydrate, -linker-(anti-cancer agent), linker-NH(CH 2 CO 2 H) 2 , -linker-CO 2 H, X is O or NR; and R is H, alkyl, cyclyl, heterocyclyl, aryl or heteroaryl, each of which can be optionally substituted.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 91.0
- Lexical Diversity: 1.90244
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13537814', '14898355', '12871226', '13504822', '14643107']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7630925655063187
- 35 USC 102 Novelty (BERT): 0.5243627362133771
- Combined Prediction Score: 0.7392195825770246
- Mean Citation Score: 299.569812
- Max Citation Score: 316.01404
- Similarity Product: 219.2766011643792

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test