PATENT CLAIM ANALYSIS

Application Number: 16010623
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-05
Patent Classification: ["378", "071000"]

Abstract:
A compact, low-cost system for the detection of counterfeit or sub-potency pharmaceuticals is implemented by use of a low power X-ray source, an incident collimator containing a series of concentric, non-parallel slits, receiving collimators containing a series of concentric, non-parallel slits, additional collimators to limit tangential divergence and a single, near room temperature energy dispersive detector that sums the plurality of diffracted x-ray beams. In this system, the tradeoff between spectral resolving power and the diffracted intensity is eliminated. Also provided are methods to determine the optimal diffraction angle for a given test material, determine the instrument geometry and design parameters, and assess the system performance and sensitivity to alignment errors.

Claim (Index 27):
A method of designing an energy dispersive X-ray diffraction system using an instrument having physical features comprising design parameters of a collimator, slit spacings, and an X-ray source intensity and design values comprising a diffraction angle, a test sample size, a maximum detector size, and a focal spot size of the X-ray source, the system having parameters comprising a diffracted peak intensity, a spectral resolution, and translational and rotational misalignments, the method comprising\n a. identifying a first diffraction angle for energy dispersive X-ray diffraction analysis by converting via computation a known angular dispersive X-ray diffraction pattern into an energy dispersive X-ray diffraction profile using Bragg's law of diffraction and then correcting the energy dispersive X-ray diffraction profile to account for the X-ray source intensity profile and then further correcting the energy dispersive X-ray diffraction profile by convoluting it with an instrument profile, the instrument profile being either an experimental or calculated profile that accounts for the physical features of the instrument, providing a resulting diffraction profile, followed by an analysis of the resulting diffraction profile to determine the number of strong diffraction peaks between 10 keV and 60 keV; b. repeating the steps of a. for additional diffraction angles to find which diffraction angle results in the greatest number of strong diffraction peaks in the energy range of 10 keV to 60 keV; c. calculating the design parameters of the collimator and slit spacings subject to geometrical constraints and symmetry operators using the fixed design values comprising the optimal diffraction angle, the test sample size, the maximum detector size, and the focal spot size of the X-ray source focal spot; and d. evaluating the system's performance by using a Monte Carlo scheme to compute the system efficiency, the diffracted peak intensity, the system's spectral resolution and taking into account possible translational and rotational misalignment of the system.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 1.55
- Patent Class: 378.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12681373', '12045110', '14394971', '15919496', '12591610']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6663664937161196
- 35 USC 102 Novelty (BERT): 0.4834041975964196
- Combined Prediction Score: 0.6480702641041496
- Mean Citation Score: 305.516212
- Max Citation Score: 402.116
- Similarity Product: 340.75454035210606

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test