PATENT CLAIM ANALYSIS

Application Number: 15935782
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["514", "640000"]

Abstract:
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.

Claim (Index 2):
The method of  claim 1 , wherein the compound has the structure of formula II: or a pharmaceutically acceptable salt thereof, wherein: the bond represented by a dashed and solid line represents a bond selected from the group consisting of a single bond and a double bond with the proviso that the dashed and solid line can only be a double bond when n is 1; R 1  is selected from a group consisting of \u2014NR 9 R 10 , \u2014C 1-9 alkylR 11 , \u2014C 2-9 alkenylR 11 , \u2014C 2-9 alkynylR 11 , -carbocyclyl-R 11 , \u2014CH(OH)C 1-9 alkylR 9 , \u2014CH(OH)C 2-9 alkenylR 9 , \u2014CH(OH)C 2-9 alkynylR 9 , \u2014CH(OH)carbocyclyl-R 9 , \u2014C(\u2550O)R 9 , \u2014C(\u2550O)C 1-9 alkylR 9 , \u2014C(\u2550O)C 2-9 alkenylR 9 , \u2014C(\u2550O)C 2-9 alkynylR 9 , \u2014C(\u2550O)C 2-9 carbocyclyl-R 9 , \u2014C(\u2550O)NR 9 R 10 , \u2014N(R 9 )C(\u2550O)R 9 , \u2014N(R 9 )C(\u2550O)NR 9 R 10 , \u2014N(R 9 )C(\u2550O)OR 9 , \u2014N(R 9 )C(\u2550O)C(\u2550NR 10 )R 9 , \u2014N(R 9 )C(\u2550O)C(\u2550CR 9 R 10 )R 9 , \u2014N(R 9 )C(\u2550O)C 1-4 alkylN(R 9 )C(\u2550O)R 9 , \u2014N(R 9 )C(\u2550NR 10 )R 9 , \u2014C(\u2550NR 10 )NR 9 R 10 , \u2014N\u2550C(R 9 )NR 9 R 10 , \u2014N(R 9 )SO 2 R 9 , \u2014N(R 9 )SO 2 NR 9 R 10 , \u2014N\u2550CHR 9 , optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, and optionally substituted heterocyclyl; R 2  and R 4  are independently selected from a group consisting of H, Cl, F, CN, CF 3 , \u2014R 9 , \u2014OR 9 , \u2014C(\u2550O)NR 9 R 10 , and \u2014C(\u2550O)OR 9 ; R 3  and R 5  are independently selected from a group consisting of H, Cl, F, CN, CF 3 , \u2014R 9 , \u2014OR 9 , \u2014C(\u2550O)NR 9 R 10 , and \u2014C(\u2550O)OR 9 , with the proviso that if the bond represented by a dashed and solid line is a double bond then R 3  and R 5  are absent; R 6  is selected from a group consisting of H, \u2014C 1-9 alkyl, C 2-9 alkenyl, \u2014C 2-9 alkynyl, \u2014C 1-9 alkylR 11 , \u2014C 2-9 alkenylR 11 , \u2014C 2-9 alkynylR 11 , \u2014C(\u2550O)OR 9 , and \u2014C 1-9 alkylCO 2 R 9 , \u2014C 2-9 alkenylCO 2 R 9 , and \u2014C 2-9 alkynylCO 2 R 9 ; each R 7  is independently selected from a group consisting of H, \u2014NR 9 R 10 , \u2014OR 9 , and \u2014C 1-9 alkylCO 2 R 9 , \u2014C 2-9 alkenylCO 2 R 9 , and \u2014C 2-9 alkynylCO 2 R 9 ; each R 8  is independently selected from a group consisting of H, \u2014NR 9 R 10 , \u2014OR 9 , and \u2014C 1-9 alkylCO 2 R 9 , \u2014C 2-9 alkenylCO 2 R 9 , and \u2014C 2-9 alkynylCO 2 R 9 ; each R 9  is independently selected from a group consisting of H, \u2014C 1-9 alkyl, C 2-9 alkenyl, \u2014C 2-9 alkynyl, \u2014C 1-9 alkylR 11 , \u2014C 2-9 alkenylR 11 , \u2014C 2-9 alkynylR 11 , optionally substituted aryl, optionally substituted heteroaryl, optionally substituted \u2014(CH 2 ) 0-3 carbocyclyl, and optionally substituted heterocyclyl; each R 10  is independently selected from a group consisting of H, \u2014C 1-9 alkyl, \u2014OR 9 , \u2014CH(\u2550NH), optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, and optionally substituted heterocyclyl; X is \u2014CO 2 H; and n is independently zero or an integer from 1 to 2.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 90.0
- Lexical Diversity: 1.18519
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15015002', '15935862', '13205112', '13953647', '15624473']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8179761479939931
- 35 USC 102 Novelty (BERT): 0.7015603325438052
- Combined Prediction Score: 0.8063345664489743
- Mean Citation Score: 571.20026
- Max Citation Score: 728.3213
- Similarity Product: 718.4611972563981

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test