PATENT CLAIM ANALYSIS

Application Number: 15891129
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-08
Patent Classification: ["424", "486000"]

Abstract:
The present disclosure encompasses biocompatible hydrogel compositions comprising covalently bonded hydrogel reaction products, as well as compositions of, methods of producing, methods of using, and kits comprising the covalently cross-linked hydrogel reaction products. The covalently cross-linked hydrogel reaction products can be derived from a cross-linking reaction of a polyquaternium-10, a chondroitin 4-sulfate, and a divinylsulfone.

Claim (Index 34):
A method of producing the covalently cross-linked hydrogel reaction product of the composition of  claim 32 , comprising:\n combining a first aqueous solution comprising the chondroitin 4-sulfate with a second aqueous solution comprising the polyquaternium-10 to form an aqueous mixture, wherein the first aqueous solution comprises the chondroitin 4-sulfate in a range of 1.6% (w/v) to 2.0% (w/v) based on volume of the first aqueous solution, and wherein the second aqueous solution comprises the polyquaternium-10 in a range of 4.2% (w/v) to 4.4% (w/v) based on volume of the second aqueous solution; adding an alkaline solution to the aqueous mixture to form an alkaline aqueous mixture; adding a third aqueous solution comprising the divinylsulfone to the alkaline aqueous mixture to form the reaction mixture, wherein the third aqueous solution comprises the divinylsulfone in a range of 2.8% (w/v) to 3.2% (w/v) based on the volume of the third aqueous solution; allowing a covalent cross-linking reaction to occur in the reaction mixture to form an intermediate reaction product; neutralizing the intermediate reaction product to form a neutralized intermediate reaction product; washing the neutralized intermediate reaction product with a buffered solution to form a washed neutralized intermediate reaction product; filtering the washed neutralized intermediate reaction product to form a filtered washed neutralized intermediate reaction product; and, adjusting pH of the filtered washed neutralized intermediate reaction product to form the covalently cross-linked hydrogel reaction product of the composition of  claim 32 .

Metadata:
- Claim Count in Document: 44.0
- Percentile: 88.0
- Lexical Diversity: 1.85294
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14918976', '15737443', '13123186', '11832380', '11470164']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6588988496393118
- 35 USC 102 Novelty (BERT): 0.49216759707803
- Combined Prediction Score: 0.6422257243831837
- Mean Citation Score: 204.995458
- Max Citation Score: 215.03378
- Similarity Product: 151.71122932411672

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test