PATENT CLAIM ANALYSIS

Application Number: 15989985
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "015200"]

Abstract:
The invention provides methods and materials for making and using variant serum albumin amino acid sequences which exhibit improved properties compared to wild type serum albumin sequences. The invention further provides methods and materials for making and using fusion proteins in which the variant serum albumin amino acid sequences are fused to a therapeutic or diagnostic agent, such as a therapeutic protein, or a functional fragment or variant thereof that maintains activity, and exhibits improved properties.

Claim (Index 5):
A method of delivery of a recombinant protein comprising a variant serum albumin polypeptide (VSA) to a subject, the method comprising:\n administering to the subject a composition comprising an isolated recombinant protein comprising a variant serum albumin polypeptide (VSA) comprising a sequence that is at least 90% identical but less than 100% identical to amino acid residues 380 to 585 of SEQ ID NO: 2, wherein the VSA comprises a mutation corresponding to position V547, wherein said VSA comprises at least one additional mutation; and wherein the VSA has an altered binding affinity for human FcRn compared to a wild type human serum albumin (HSA).

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.7234
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13985227', '13578688', '14181339', '15915977', '15753947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7237013247652205
- 35 USC 102 Novelty (BERT): 0.5410281119516119
- Combined Prediction Score: 0.7054340034838598
- Mean Citation Score: 294.638252
- Max Citation Score: 307.64963
- Similarity Product: 236.8679843675924

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test