PATENT CLAIM ANALYSIS

Application Number: 16272507
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-05
Patent Classification: ["435", "190000"]

Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl (1,3-oxazolidin-3-yl))-1-(4-fluorophenyl) pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe.

Claim (Index 3):
An expression vector comprising the polynucleotide of  claim 1 , operably linked to one or more control sequences suitable for directing expression of the encoded polypeptide in a host cell.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 99.0
- Lexical Diversity: 1.83333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15711070', '16031177', '15211505', '13590882', '12545034']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8032253047406405
- 35 USC 102 Novelty (BERT): 0.597857845218212
- Combined Prediction Score: 0.7826885587883976
- Mean Citation Score: 515.2589019999998
- Max Citation Score: 519.2958
- Similarity Product: 511.4160512037277

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test