PATENT CLAIM ANALYSIS

Application Number: 15755475
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "046000"]

Abstract:
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Claim (Index 4):
The compound according to  claim 1 , wherein\n R 1  represents hydrogen or \u2014C(\u2550O)\u2014C 1-4 alkyl; R 2  represents hydrogen or \u2014C(\u2550O)\u2014C 1-4 alkyl; Y represents \u2014O\u2014; Z represents \u2014X\u2014CR 5a R 5b \u2014; R 5a  and R 5b  each independently represent hydrogen or C 1-4 alkyl; X represents \u2014O\u2014, \u2014S\u2014, or \u2014NR 11 \u2014; R 11  represents hydrogen; Ar represents Ar is optionally substituted with one or two substituents each independently selected from the group consisting of halo, \u2014OH, \u2014NH 2 , \u2014NH\u2014C 1-4 alkyl, \u2014N(C 1-4 alkyl) 2 , cyano, \u2014CF 3 , \u2014C(\u2550O)\u2014NH\u2014C 1-4 alkyl, \u2014C(\u2550O)\u2014C 1-4 alkyl, C 1-4 alkyloxy, and C 1-4 alkyl optionally substituted with one \u2014NR 10a R 10b ; R 10a  and R 10b  each independently represent hydrogen or C 1-4 alkyl; Het represents a bicyclic aromatic heterocyclic ring system selected from the group consisting of (a-1); R 3a  represents hydrogen, halo, \u2014NR 7a R 7b , or \u2014O\u2014C 1-4 alkyl; R 7a  represents hydrogen; R 7b  represents hydrogen; R 4a  represents hydrogen, halo, \u2014NR 8a R 8b , or C 1-4 alkyl; R 8a  and R 8b  each independently represent hydrogen or C 1-4 alkyl; Q 1  represents CR 6a ; Q 2  represents CR 6b ; R 6a  and R 6b  each independently represent hydrogen, halogen, C 1-4 alkyl, \u2014NR 9a R 9b , or C 1-4 alkyl substituted with one, two or three halo atoms; R 9a  and R 9b  each independently represent hydrogen or C 1-4 alkyl.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 1.45652
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13207696', '16331579', '15502884', '14619371', '13983248']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7735173042436422
- 35 USC 102 Novelty (BERT): 0.5209335703121264
- Combined Prediction Score: 0.7482589308504907
- Mean Citation Score: 301.543934
- Max Citation Score: 304.53442
- Similarity Product: 223.45553883179423

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test