PATENT CLAIM ANALYSIS

Application Number: 16048677
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["544", "106000"]

Abstract:
The present invention provides MDM2 inhibitor compounds of Formula I, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Claim (Index 44):
A compound, or a pharmaceutically acceptable salt thereof, selected from:\n 1,1-dimethylethyl (2R,3S)-2,3-bis(4-bromophenyl)-5-oxo-1-piperazinecarboxylate; 1,1-dimethylethyl (2S,3R)-2,3-bis(4-bromophenyl)-5-oxo-1-piperazinecarboxylate; (2R,5S,6R)-5,6-bis(4-bromophenyl)-4-methyl-2-(2-propen-1-yl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-bromophenyl)-4-methyl-2-(2-propen-1-yl)-3-morpholinone; (5R,6S)-5,6-bis(4-bromophenyl)-4-cyclopropyl-3-morpholinone; (5 S,6R)-5,6-bis(4-bromophenyl)-4-cyclopropyl-3-morpholinone; (2S,5R,6S)-5,6-bis(4-bromophenyl)-2,4-dimethyl-3-morpholinone; (2R,5R,6S)-5,6-bis(4-bromophenyl)-2,4-dimethyl-3-morpholinone; (2R,5S,6R)-5,6-bis(4-bromophenyl)-4-cyclopropyl-2-(phenylmethyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-bromophenyl)-4-cyclopropyl-2-(phenylmethyl)-3-morpholinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R,5S,6R)-5,6-bis(4-bromophenyl)-4-methyl-2-phenyl-3-morpholinone; (2S,5R,6S)-5,6-bis(4-bromophenyl)-4-methyl-2-phenyl-3-morpholinone; N-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyano-3-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)glycine; (5R,6S)-5,6-bis(4-bromophenyl)-1-methyl-4-(phenylmethyl)-2-piperazinone; (5 S,6R)-5,6-bis(4-bromophenyl)-1-methyl-4-(phenylmethyl)-2-piperazinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(3-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R,5S,6R)-5,6-bis(4-bromophenyl)-4-methyl-2-(3-methyl-2-buten-1-yl)-3-morpholinone; (2 S, 5R,6S)-5,6-bis(4-bromophenyl)-4-methyl-2-(3-methyl-2-buten-1-yl)-3-morpholinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyano-3-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (5R,6S)-5,6-bis(4-bromophenyl)-4-(phenylmethyl)-2-piperazinone; (5 S,6R)-5,6-bis(4-bromophenyl)-4-(phenylmethyl)-2-piperazinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (5R,6S)-5,6-bis(4-chlorophenyl)-4-((1R)-2-hydroxy-1-phenylethyl)-3-morpholinone; (5R,6S)-5,6-bis(4-chlorophenyl)-4-((1S)-2-hydroxy-1-phenylethyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-((1R)-2-hydroxy-1-phenylethyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-((1S)-2-hydroxy-1-phenylethyl)-3-morpholinone; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-3-phenylpropanoic acid; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-3-phenylpropanoic acid; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-3-phenylpropanoic acid; (5R,6S)-5,6-bis(4-chlorophenyl)-4-((1R)-1-(hydroxymethyl)butyl)-3-morpholinone; (5S,6R)-5,6-bis(4-chlorophenyl)-4-((1S)-1-(hydroxymethyl)butyl)-3-morpholinone; (5R,6S)-5,6-bis(4-chlorophenyl)-4-((1S)-1-(hydroxymethyl)butyl)-3-morpholinone; (5S,6R)-5,6-bis(4-chlorophenyl)-4-((1R)-1-(hydroxymethyl)butyl)-3-morpholinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(2-methoxybenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-((2 S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)(4-chlorophenyl)ethanoic acid; (2S)-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)(4-chlorophenyl)ethanoic acid; (2S)-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)(4-chlorophenyl)ethanoic acid; (2R)-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)(4-chlorophenyl)ethanoic acid; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1S)-1-(hydroxymethyl)butyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1R)-1-(hydroxymethyl)butyl)-3-morpholinone; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1R)-1-(hydroxymethyl)butyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-(1S)-1-(hydroxymethyl)butyl)-3-morpholinone; (5R,6S)-5,6-bis(4-chlorophenyl)-4-((1R)-1-(4-chlorophenyl)-2-hydroxyethyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-((1R S)-1-(4-chlorophenyl)-2-hydroxyethyl)-3-morpholinone; (5R,6S)-5,6-bis(4-chlorophenyl)-4-((1R S)-1-(4-chlorophenyl)-2-hydroxyethyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-((1R)-1-(4-chlorophenyl)-2-hydroxyethyl)-3-morpholinone; (5R,6S)-5,6-bis(4-chlorophenyl)-4-((1R)-1-(1-hydroxy-1-methylethyl)butyl)-3-morpholinone; (5S,6R)-5,6-bis(4-chlorophenyl)-4-((S)-1-(1-hydroxy-1-methylethyl)butyl)-3-morpholinone; (5R,6S)-5,36-bis(4-chlorophenyl)-4-((6S)-1-(1-hydroxy-1-methylethyl)butyl)-3-morpholinone; (5S,6R)-5,6-bis(4-chlorophenyl)-4-((1R)-1-(1-hydroxy-1-methylethyl)butyl)-3-morpholinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R,6)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl carbamate; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl carbamate; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl carbamate; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl carbamate; (2R)-2-((2S,3R,6S)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S,6R)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R)-1-methylbutyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S)-1-methylbutyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S)-1-methylbutyl)-3-oxo-2-morpholinyl)acetic acid; ((2 S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R)-1-methylbutyl)-3-oxo-2-morpholinyl)acetic acid; (2R)-2-((2S,3R)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2S,3R)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2R,3S)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(4-chlorophenyl)ethanoic acid; (2S)-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(4-chlorophenyl)ethanoic acid; (2S)-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(4-chlorophenyl)ethanoic acid; (2R)-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(4-chlorophenyl)ethanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-2-(4-chlorophenyl)ethanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-2-(4-chlorophenyl)ethanamide; (2S)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-2-(4-chlorophenyl)ethanamide; (2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-2-(4-chlorophenyl)ethanamide; methyl 4-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)butanoate; (2R)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-((2R)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-((2S)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-((2R)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-((2S)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-((2S)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-((2R)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-((2S)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-((2R)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-2-(4-chlorophenyl)ethanamide; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-2-(4-chlorophenyl)ethanamide; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-2-(4-chlorophenyl)ethanamide; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-2-(4-chlorophenyl)ethanamide; (2R)-2-((2S,3R,6S)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6S)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2S,3R,6S)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2R,3S,6S)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(2-(4-methyl-1-piperazinyl)ethyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-methylpentanamide; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-methylpentanamide; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-methylpentanamide; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-methylpentanamide; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-(2-hydroxyethyl)pentanamide; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-(2-hydroxyethyl)pentanamide; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-(2-hydroxyethyl)pentanamide; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-(2-hydroxyethyl)pentanamide; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N,N-dimethylpentanamide; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N,N-dimethylpentanamide; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N,N-dimethylpentanamide; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N,N-dimethylpentanamide; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-(2-(4-morpholinyl)ethyl)pentanamide; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-(2-(4-morpholinyl)ethyl)pentanamide; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-(2-(4-morpholinyl)ethyl)pentanamide; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-(2-(4-morpholinyl)ethyl)pentanamide; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(3-(1H-imidazol-1-yl)propyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-propylpentanamide; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-propylpentanamide; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-propylpentanamide; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-N-propylpentanamide; (5R,6S)-4-((1R)-1-(aminomethyl)butyl)-5,6-bis(4-chlorophenyl)-3-morpholinone; (5 S,6R)-4-((1S)-1-(aminomethyl)butyl)-5,6-bis(4-chlorophenyl)-3-morpholinone; (5R,6S)-4-((1S)-1-(aminomethyl)butyl)-5,6-bis(4-chlorophenyl)-3-morpholinone; (5S,6R)-4-((1R)-1-(aminomethyl)butyl)-5,6-bis(4-chlorophenyl)-3-morpholinone; (2R)-2-((2S,3R,6S)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6R)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2S,3R,6S)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2R,3S,6R)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-5-oxo-6-(2-propen-1-yl)-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-5-oxo-6-(2-propen-1-yl)-4-morpholinyl)pentanamide; (2S)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-5-oxo-6-(2-propen-1-yl)-4-morpholinyl)pentanamide; (2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-5-oxo-6-(2-propen-1l-yl)-4-morpholinyl)pentanamide; (2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; N-((2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)-2-hydroxyacetamide; N-((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)-2-hydroxyacetamide; N-((2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)-2-hydroxyacetamide; N-((2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)-2-hydroxyacetamide; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(3-methoxybenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (3R)-3-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)hexanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-5-oxo-6-(2-propen-1-yl)-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-5-oxo-6-(2-propen-1-yl)-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-((2S)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-((2R)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-((2R)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-((2S)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-((2R)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-((2S)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-((2R)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-((2S)-2,3-dihydroxypropyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,5R,6S)-2-(2-amino-2-oxoethyl)-5,6-bis(4-chlorophenyl)-3-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,5S,6R)-2-(2-amino-2-oxoethyl)-5,6-bis(4-chlorophenyl)-3-oxo-4-morpholinyl)pentanoic acid; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S)-1-(((cyclopropylsulfonyl)(phenyl)amino)methyl)propyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R)-1-(((cyclopropylsulfonyl)(phenyl)amino)methyl)propyl)-3-oxo-2-morpholinyl)acetic acid; ((2 S, 5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S)-1-(((cyclopropylsulfonyl)(phenyl)amino)methyl)propyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R)-1-(((cyclopropylsulfonyl)(phenyl)amino)methyl)propyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R)-1-(((cyclopropylsulfonyl)(phenyl)amino)methyl)propyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S)-1-(((cyclopropylsulfonyl)(phenyl)amino)methyl)propyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R)-1-(((cyclopropylsulfonyl)(phenyl)amino)methyl)propyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S)-1-(((cyclopropylsulfonyl)(phenyl)amino)methyl)propyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5S,6R)-4-((1S)-1-carbamoylbutyl)-5,6-bis(4-chlorophenyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-4-((1R)-1-carbamoylbutyl)-5,6-bis(4-chlorophenyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S)-1-(ethoxycarbonyl)butyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R)-1-(ethoxycarbonyl)butyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R)-1-(ethoxycarbonyl)butyl)-3-oxo-2-morpholinyl)acetic acid; ((2 S, 5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1S)-1-(ethoxycarbonyl)butyl)-3-oxo-2-morpholinyl)acetic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-N-(2-(4-morpholinyl)ethyl)pentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-N-(2-(4-morpholinyl)ethyl)pentanamide; (5R,6S)-5,6-bis(4-chlorophenyl)-4-((1R)-1-(4-morpholinylmethyl)butyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-((1S)-1-(4-morpholinylmethyl)butyl)-3-morpholinone; N-((2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)methanesulfonamide; N-((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)methanesulfonamide; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1S)-1-((4-methyl-1-piperazinyl)carbonyl)butyl)-3-morpholinone; (2 S, 5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1R)-1-((4-methyl-1-piperazinyl)carbonyl)butyl)-3-morpholinone; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1S)-1-(4-morpholinylcarbonyl)butyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1R)-1-(4-morpholinylcarbonyl)butyl)-3-morpholinone; (2R,5S,6R)-4-((1S)-1-(aminomethyl)butyl)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-3-morpholinone; (2S,5R,6S)-4-((1R)-1-(aminomethyl)butyl)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-3-morpholinone; (5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methyl-3-morpholinone; (5 S,6R)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methyl-3-morpholinone; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylsulfonyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylsulfonyl)-3-oxo-2-morpholinyl)acetic acid; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1S)-1-(4-morpholinylmethyl)butyl)-3-morpholinone; (2 S, 5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1R)-1-(4-morpholinylmethyl)butyl)-3-morpholinone; (2R)-2-((2S,3R,6S)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-2-phenyl-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-2-phenyl-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-2-phenyl-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S,6R)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-2-phenyl-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(2-(4-morpholinyl)ethyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(phenyl)ethanoic acid; (2S)-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(phenyl)ethanoic acid; (2S)-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(phenyl)ethanoic acid; (2R)-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(phenyl)ethanoic acid; (2R)-2-((2S,3R)-2-(4-chlorophenyl)-3-(3,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-2-(4-chlorophenyl)-3-(3,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-2-(4-chlorophenyl)-3-(3,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S)-2-(4-chlorophenyl)-3-(3,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(1-methylethyl)-3-thiomorpholinone 1,1-dioxide; (2R)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(2-(4-morpholinyl)-2-oxoethyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(2-(4-morpholinyl)-2-oxoethyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(2-(4-morpholinyl)-2-oxoethyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(2-(4-morpholinyl)-2-oxoethyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R)-3-(4-bromophenyl)-2-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-3-(4-bromophenyl)-2-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-3-(4-bromophenyl)-2-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S)-3-(4-bromophenyl)-2-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-5-oxo-6-(2-(1-piperidinyl)ethyl)-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R)-2-(4-chlorophenyl)-3-(4-cyclopropylphenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-2-(4-chlorophenyl)-3-(4-cyclopropylphenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-2-(4-chlorophenyl)-3-(4-cyclopropylphenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S)-2-(4-chlorophenyl)-3-(4-cyclopropylphenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-3-(4-bromophenyl)-2-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-3-(4-bromophenyl)-2-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-3-(4-bromophenyl)-2-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S,6R)-3-(4-bromophenyl)-2-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; 2-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzonitrile; 2-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzonitrile; (2R)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(2-fluoro-4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(2-fluoro-4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)hexanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)hexanoic acid; (2S)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)hexanoic acid; (2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)hexanoic acid; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1S)-1-(1H-tetrazol-5-yl)butyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-((1R)-1-(1H-tetrazol-5-yl)butyl)-3-morpholinone; N-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)glycine; N-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)glycine; (2R)-2-((2S,3R,6S)-3-(4-bromophenyl)-2-(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-3-(4-bromophenyl)-2-(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; 3-((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)propanenitrile; 3-((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)propanenitrile; 2-((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)-N-(2-(4-morpholinyl)ethyl)acetamide; 2-((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)-N-(2-(4-morpholinyl)ethyl)acetamide; (2R)-2-((2S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (S)-2-((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)-2-hydroxyacetic acid; (R)-2-((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)-2-hydroxyacetic acid; (R)-2-((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)-2-hydroxyacetic acid; (S)-2-((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)-2-hydroxyacetic acid; ((2S,5R,6S)-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)acetic acid; ((2R,5S,6R)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-4-butyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-2-morpholinyl)acetic acid; (2R)-2-((2S,3R)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; N\u2032-acetyl-2-((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)acetohydrazide; N\u2032-acetyl-2-((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)acetohydrazide; (2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(2-(4-morpholinyl)-2-oxoethyl)-3-morpholinone; (2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(2-(4-morpholinyl)-2-oxoethyl)-3-morpholinone; (2R)-2-((2S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanamide; 2-((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)ethyl carbamate; 2-((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)ethyl carbamate; (2R)-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(3-chlorophenyl)ethanoic acid; (2S)-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(3-chlorophenyl)ethanoic acid; (2S)-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(3-chlorophenyl)ethanoic acid; (2R)-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(3-chlorophenyl)ethanoic acid; (2R)-2-((2S,3R,6S)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S,6R)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; 4-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)butanoic acid; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1R)-1-(((cyclopropylsulfonyl)(phenyl)amino)methyl)propyl)-3-oxo-2-morpholinyl)acetic acid and 3-((2R,3S)-3-(4-chlorophenyl)-4-(cyclopropylmethyl)-5-oxo-2-morpholinyl)benzonitrile; 3-((2S,3R)-3-(4-chlorophenyl)-4-(cyclopropylmethyl)-5-oxo-2-morpholinyl)benzonitrile; (2R)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; N-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)glycine; N-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)glycine; N-((2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)glycine; N-((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)glycine; 2-((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)-N,N-dimethylacetamide; 2-((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)-N,N-dimethylacetamide; ethyl (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(3-(4-morpholinyl)propyl)-5-oxo-4-morpholinyl)pentanoate; (2R)-2-((2S,3R)-3-(4-chlorophenyl)-2-(4-cyanophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-3-(4-chlorophenyl)-2-(4-cyanophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-3-(4-chlorophenyl)-2-(4-cyanophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S)-3-(4-chlorophenyl)-2-(4-cyanophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(3-hydroxypropyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentanamide; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-4-pentenoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-4-pentenoic acid; (2S)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-4-pentenoic acid; (2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-4-pentenoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentanenitrile; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentanenitrile; 4-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-3-oxo-4-((1S)-1-(1H-tetrazol-5-yl)butyl)-2-morpholinyl)methyl)benzonitrile; 4-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-3-oxo-4-((1R)-1-(1H-tetrazol-5-yl)butyl)-2-morpholinyl)methyl)benzonitrile; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-morpholinone; (5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-morpholinone; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(((1R,2R)-2-methylcyclopropyl)methyl)-3-morpholinone; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(((1 S,2S)-2-methylcyclopropyl)methyl)-3-morpholinone; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(((1R,2R)-2-methylcyclopropyl)methyl)-3-morpholinone; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(((1 S,2S)-2-methylcyclopropyl)methyl)-3-morpholinone; N-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-beta-alanine; N-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-beta-alanine; N-((2S)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-beta-alanine; N-((2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-beta-alanine; N-((2R)-2-((2R,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-beta-alanine; N-((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-beta-alanine; N-((2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-beta-alanine; N-((2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-beta-alanine; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylsulfonyl)-3-morpholinone; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylsulfonyl)-3-morpholinone; 4-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzamide; 4-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzamide; (3R)-3-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)hexanoic acid; (((2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)oxy)acetic acid; (((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)oxy)acetic acid; (2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoic acid; 4-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)-2-fluorobenzonitrile; 4-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)-2-fluorobenzonitrile; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-(4-pyridinyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-(4-pyridinyl)-3-morpholinone; (2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-3-morpholinone; (2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-3-morpholinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyano-2-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyano-2-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2,2,6-trimethyl-4-(1-methylethyl)-3-thiomorpholinone 1,1-dioxide; (5 S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2,2,6-trimethyl-4-(1-methylethyl)-3-thiomorpholinone 1,1-dioxide; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2,2,6-trimethyl-4-(1-methylethyl)-3-thiomorpholinone 1,1-dioxide; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2,2,6-trimethyl-4-(1-methylethyl)-3-thiomorpholinone 1,1-dioxide; 3-(((2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)amino)-3-oxopropanoic acid; 3-(((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)amino)-3-oxopropanoic acid; N-((2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)glycine; N-((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)glycine; ((2R,5S,6R)-6-(3-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-6-(3-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)acetic acid; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-2-(4-(methyl sulfonyl)benzyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-2-(4-(methylsulfonyl)benzyl)-3-morpholinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)-N-(1H-tetrazol-5-ylmethyl)pentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)-N-(1H-tetrazol-5-ylmethyl)pentanamide; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylcarbonyl)-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylcarbonyl)-3-oxo-2-morpholinyl)acetic acid; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-thiomorpholinone 1,1-dioxide; 2-((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)ethyl methanesulfonate; 2-((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxo-2-morpholinyl)ethyl methanesulfonate; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)-N-(2-(1H-tetrazol-5-yl)ethyl)pentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)-N-(2-(1H-tetrazol-5-yl)ethyl)pentanamide; N-((2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)-2-(1H-tetrazol-5-yl)acetamide; N-((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentyl)-2-(1H-tetrazol-5-yl)acetamide; 4-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)butanoic acid; 4-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)butanoic acid; (5R,6S)-5,6-bis(4-chlorophenyl)-4-(2-(methylsulfanyl)-4-pyrimidinyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-(2-(methylsulfanyl)-4-pyrimidinyl)-3-morpholinone; 1-((2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-4-piperidinecarboxylic acid; 1-((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-4-piperidinecarboxylic acid; (4-((2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-1-piperazinyl)acetic acid; (4-((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-1-piperazinyl)acetic acid; (2S)-4-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-2-hydroxybutanoic acid; (2S)-4-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-2-hydroxybutanoic acid; (3R)-4-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-3-hydroxybutanoic acid; (3R)-4-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-3-hydroxybutanoic acid; (3S)-4-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-3-hydroxybutanoic acid; (3S)-4-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-3-hydroxybutanoic acid; (2R)-3-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-2-methylpropanoic acid; (2R)-3-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-2-methylpropanoic acid; (2S)-3-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-2-methylpropanoic acid; (2S)-3-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-2-methylpropanoic acid; N-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-L-alanine; N-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-D-alanine; (2R)-2-((2R,3S)-2-(4-chlorophenyl)-3-(1H-indol-2-yl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-2-(4-chlorophenyl)-3-(1H-indol-2-yl)-5-oxo-4-morpholinyl)pentanoic acid; N-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-D-alanine; N-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-L-alanine; methyl 4-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzoate; methyl 4-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzoate; 3-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-N-(tert-butoxycarbonyl)-D-alanine; 3-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-N-(tert-butoxycarbonyl)-D-alanine; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclobutylmethyl)-3-morpholinone; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclobutylmethyl)-3-morpholinone; 4-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzonitrile; 4-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzonitrile; (4-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-1-piperazinyl)acetic acid; (4-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-1-piperazinyl)acetic acid; 3-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-2,2-dimethylpropanoic acid; 3-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-2,2-dimethylpropanoic acid; (5R,6S)-5,6-bis(4-chlorophenyl)-4-(2-chloro-4-pyridinyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-(2-chloro-4-pyridinyl)-3-morpholinone; 3-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzamide; 3-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzamide; 3-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-D-alanine; 3-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)-D-alanine; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-methoxybenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-methoxybenzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2 S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; 3-(4-((2R)-2-((2 S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-1-piperazinyl)propanoic acid; 3-(4-((2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoyl)-1-piperazinyl)propanoic acid; (2R)-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(cyclopropyl)ethanoic acid; (2S)-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(cyclopropyl)ethanoic acid; (2S)-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(cyclopropyl)ethanoic acid; (2R)-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)(cyclopropyl)ethanoic acid; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-(1-methyl-1H-imidazol-4-yl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-(1-methyl-1H-imidazol-4-yl)-3-morpholinone; 4-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzoic acid; 4-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzoic acid; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methylpropyl)-3-morpholinone; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methylpropyl)-3-morpholinone; 1-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-D-proline; 1-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-D-proline; (5R,6S)-5,6-bis(4-chlorophenyl)-4-(2-pyrazinyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-(2-pyrazinyl)-3-morpholinone; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-((2R)-2,3-dihydroxypropyl)-3-morpholinone; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-((2S)-2,3-dihydroxypropyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-((2R)-2,3-dihydroxypropyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-((2S)-2,3-dihydroxypropyl)-3-morpholinone; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-cyclopentyl-3-morpholinone; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-cyclopentyl-3-morpholinone; methyl 1-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-L-prolinate; methyl 1-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-L-prolinate; 1-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-4-piperidinecarboxylic acid; 1-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-4-piperidinecarboxylic acid; (2R)-2-((2S,5R,6S)-2-(4-chlorobenzyl)-5,6-bis(4-chlorophenyl)-3-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,5S,6R)-2-(4-chlorobenzyl)-5,6-bis(4-chlorophenyl)-3-oxo-4-morpholinyl)pentanoic acid; (2R,5S,6R)-2-(4-(aminomethyl)benzyl)-5,6-bis(4-chlorophenyl)-4-methyl-3-morpholinone; (2S,5R,6S)-2-(4-(aminomethyl)benzyl)-5,6-bis(4-chlorophenyl)-4-methyl-3-morpholinone; 3-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentyl)amino)-3-oxopropanoic acid; 3-(((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentyl)amino)-3-oxopropanoic acid; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(1,3-thiazol-4-ylmethyl)-3-morpholinone; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(1,3-thiazol-4-ylmethyl)-3-morpholinone; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-hydroxy-2-methylpropyl)-3-morpholinone; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-hydroxy-2-methylpropyl)-3-morpholinone; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1-cyanocyclopropyl)methyl)-3-oxo-2-morpholinyl)acetic acid; ((2 S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-((1-cyanocyclopropyl)methyl)-3-oxo-2-morpholinyl)acetic acid; 1-((((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)methyl)cyclopentanecarboxylic acid; 1-((((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)methyl)cyclopentanecarboxylic acid; (3S)-3-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)hexanoic acid; (3S)-3-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)hexanoic acid; (2R)-2-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentanoi acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentanoi acid; (5R,6S)-5,6-bis(4-chlorophenyl)-4-(4-pyridinyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-(4-pyridinyl)-3-morpholinone; (2R)-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)(cyclopropyl)ethanoic acid; (2R)-((2S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)(cyclopropyl)ethanoic acid; (2S)-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)(cyclopropyl)ethanoic acid; (2S)-((2S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxo-4-morpholinyl)(cyclopropyl)ethanoic acid; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,5R,6S)-2-(4-biphenylylmethyl)-5,6-bis(4-chlorophenyl)-3-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,5S,6R)-2-(4-biphenylylmethyl)-5,6-bis(4-chlorophenyl)-3-oxo-4-morpholinyl)pentanoic acid; ethyl (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyano-2-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoate; ethyl (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyano-2-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoate; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-((dimethylamino)methyl)benzyl)-4-methyl-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-((dimethylamino)methyl)benzyl)-4-methyl-3-morpholinone; (5R,6S)-5,6-bis(4-chlorophenyl)-6-methyl-3-morpholinone and (5S,6R)-5,6-bis(4-chlorophenyl)-6-methyl-3-morpholinone; (2R)-2-((2S,5R,6S)-2-(4-carbamoylbenzyl)-5,6-bis(4-chlorophenyl)-3-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,5S,6R)-2-(4-carbamoylbenzyl)-5,6-bis(4-chlorophenyl)-3-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-5-oxo-6-(4-(1H-pyrazol-1-yl)benzyl)-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-5-oxo-6-(4-(1H-pyrazol-1-yl)benzyl)-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-5-oxo-6-(4-(1H-pyrrol-1-yl)benzyl)-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-5-oxo-6-(4-(1H-pyrrol-1-yl)benzyl)-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)hexanoic acid; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)hexanoic acid; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)hexanoic acid; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)hexanoic acid; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (5R,6S)-5,6-bis(4-chlorophenyl)-4-(3-pyridinyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-(3-pyridinyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-bromophenyl)-4-(1-methylethyl)-3-morpholinone; (5R,6S)-5,6-bis(4-bromophenyl)-4-(1-methylethyl)-3-morpholinone; (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methoxyethyl)-3-morpholinone; (5 S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methoxyethyl)-3-morpholinone; (2R)-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)(phenyl)ethanoic acid; (2S)-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)(phenyl)ethanoic acid; (2S)-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)(phenyl)ethanoic acid; (2R)-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)(phenyl)ethanoic acid; (2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(2-fluoro-4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(2-fluoro-4-(methylsulfonyl)benzyl)-5-oxo-4-morpholinyl)pentanoic acid; ((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)acetonitrile; ((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)acetonitrile; (5R,6S)-5,6-bis(4-chlorophenyl)-4-phenyl-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-phenyl-3-morpholinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-5-oxo-6-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-5-oxo-6-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-2-(1H-tetrazol-5-ylmethyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-2-(1H-tetrazol-5-ylmethyl)-3-morpholinone; (2R)-2-((2S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2S,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2R,3S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-2-methyl-5-oxo-4-morpholinyl)pentanoic acid; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-4-methylpentanoic acid; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-4-methylpentanoic acid; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-4-methylpentanoic acid; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-4-methylpentanoic acid; 4-(((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)pentanoyl)amino)butanoic acid; ((2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-6-methyl-3-oxo-2-morpholinyl)acetic acid; ((2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-6-methyl-3-oxo-2-morpholinyl)acetic acid; (4R)-4-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)heptanoic acid; and (4S)-4-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)heptanoic acid; (4R)-4-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)heptanoic acid; (4S)-4-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)heptanoic acid; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)butanoic acid; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)butanoic acid; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)butanoic acid; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)butanoic acid; (5R,6S)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-bromophenyl)-4-ethyl-3-morpholinone; (5R,6S)-5,6-bis(4-bromophenyl)-4-ethyl-3-morpholinone; 2-((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)acetamide; 2-((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)acetamide; (2R)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-2-(4-fluorobenzyl)pentanoic acid; (2S)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-2-(4-fluorobenzyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-2-(4-fluorobenzyl)pentanoic acid; (2R)-2-((2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-2-(4-fluorobenzyl)pentanoic acid; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-(2-hydroxyethyl)-4-methyl-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-(2-hydroxyethyl)-4-methyl-3-morpholinone; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-((2R)-2,3-dihydroxypropyl)-4-methyl-3-morpholinone; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-((2S)-2,3-dihydroxypropyl)-4-methyl-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-((2R)-2,3-dihydroxypropyl)-4-methyl-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-((2S)-2,3-dihydroxypropyl)-4-methyl-3-morpholinone; 1-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentyl)-4-piperidinecarboxylic acid; 1-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentyl)-4-piperidinecarboxylic acid; N-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-N-methylglycine; N-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-N-methylglycine; (3R,5R,6S)-5,6-bis(4-chlorophenyl)-3-propyl-2,5,6,8-tetrahydro-3H-imidazo[2,1-c][1,4]oxazine; (3 S,5S,6R)-5,6-bis(4-chlorophenyl)-3-propyl-2,5,6,8-tetrahydro-3H-imidazo[2,1-c][1,4]oxazine; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(2-(dimethylamino)ethyl)-5-oxo-4-morpholinyl)pentanoic acid; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(2-(dimethylamino)ethyl)-5-oxo-4-morpholinyl)pentanoic acid; N-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-N-methyl-beta-alanine; N-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-N-methyl-beta-alanine; 4-(((2S,5R,6S)-5-(4-chlorophenyl)-4-methyl-6-(2-methylpropyl)-3-oxo-2-morpholinyl)methyl)-2-fluorobenzonitrile; 4-(((2R,5S,6R)-5-(4-chlorophenyl)-4-methyl-6-(2-methylpropyl)-3-oxo-2-morpholinyl)methyl)-2-fluorobenzonitrile; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)propanoic acid; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)propanoic acid; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)propanoic acid; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)propanoic acid; (5R,6S)-5,6-bis(4-chlorophenyl)-4-(2,6-dichloro-4-pyridinyl)-3-morpholinone; (5 S,6R)-5,6-bis(4-chlorophenyl)-4-(2,6-dichloro-4-pyridinyl)-3-morpholinone; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)-N-hydroxypentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-iodobenzyl)-5-oxo-4-morpholinyl)-N-hydroxypentanamide; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-N-(cyclopropylsulfonyl)pentanamide; (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxo-4-morpholinyl)-N-(cyclopropylsulfonyl)pentanamide; (2R)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-3-methylbutanoic acid; (2R)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-3-methylbutanoic acid; (2S)-2-((2R,3S)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-3-methylbutanoic acid; (2S)-2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxo-4-morpholinyl)-3-methylbutanoic acid; (2R,5R,6S)-5,6-bis(4-chlorophenyl)-2-hydroxy-4-methyl-3-morpholinone; (2S,5S,6R)-5,6-bis(4-chlorophenyl)-2-hydroxy-4-methyl-3-morpholinone; (2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-((1S)-1-((4-(cyclopropylmethyl)-1-piperazinyl)carbonyl)butyl)-2-(4-iodobenzyl)-3-morpholinone; (2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-((1R)-1-((4-(cyclopropylmethyl)-1-piperazinyl)carbonyl)butyl)-2-(4-iodobenzyl)-3-morpholinone; (3R,5S,6R)-5,6-bis(4-chlorophenyl)-3-propyl-2,5,6,8-tetrahydro-3H-imidazo[2,1-c][1,4]oxazine; (3 S, 5R,6S)-5,6-bis(4-chlorophenyl)-3-propyl-2,5,6,8-tetrahydro-3H-imidazo[2,1-c][1,4]oxazine; 1-((2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-3-azetidinecarboxylic acid; 1-((2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)pentanoyl)-3-azetidinecarboxylic acid; 3-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzoic acid; 3-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzoic acid; (2R,5R,6S)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-(3-pyridinyl)-3-morpholinone; (2S,5S,6R)-5,6-bis(4-chlorophenyl)-2-(4-fluorobenzyl)-4-(3-pyridinyl)-3-morpholinone; 4-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-((1S)-1-((4-(cyclopropylmethyl)-1-piperazinyl)carbonyl)butyl)-3-oxo-2-morpholinyl)methyl)benzonitrile; 4-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-((1R)-1-((4-(cyclopropylmethyl)-1-piperazinyl)carbonyl)butyl)-3-oxo-2-morpholinyl)methyl)benzonitrile; 3-(((2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzonitrile; 3-(((2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxo-2-morpholinyl)methyl)benzonitrile; (2R)-2-((2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)-N-(methylsulfonyl)pentanamide; or (2S)-2-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxo-4-morpholinyl)-N-(methyl sulfonyl)pentanamide.

Metadata:
- Claim Count in Document: 55.0
- Percentile: 95.0
- Lexical Diversity: 1.35
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14347628', '15047523', '13308287', '12228421', '10131938']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.831982379646221
- 35 USC 102 Novelty (BERT): 0.5507498705666063
- Combined Prediction Score: 0.8038591287382595
- Mean Citation Score: 412.642012
- Max Citation Score: 422.45053
- Similarity Product: 368.64514634341657

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test