PATENT CLAIM ANALYSIS

Application Number: 15752635
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "265100"]

Abstract:
Janus kinase 1 selective inhibitors and pharmaceutical use thereof are provided.

Claim (Index 2):
The compound according to  claim 1 , or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein the compound of Formula 1 is\n (R)-3-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)-3-oxopropanenitrile; (R)-3-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)propanenitrile; (R)\u2014N-(1-butylpyrrolidine-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)-2-azido-1-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)ethane-1-one; (R)-3-methyl-1-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)butane-1-one; isobutyl(R)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-carboxylate; (R)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)-N-phenylpyrrolidine-1-carboxamide; (R)\u2014N-methyl-N-(1-(methylsulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-((trifluoromethyl)sulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-(1-(ethylsulfonyl)pyrrolidine-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-(propylsulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-(1-(isopropylsulfonyl)pyrrolidine-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-((1-methyl-1H-imidazole-4-yl)sulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-(phenylsulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-(1-((2-fluorophenyl)sulfonyl)pyrrolidine-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-(1-((3-fluorophenyl)sulfonyl)pyrrolidine-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-(1-((4-fluorophenyl)sulfonyl)pyrrolidine-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)-2-((3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)sulfonyl)benzonitrile; (R)-3-((3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)sulfonyl)benzonitrile; (R)-4-((3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)sulfonyl)benzonitrile; (R)\u2014N-methyl-N-(1-((2-nitrophenyl)sulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-((3-nitrophenyl)sulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-((4-nitrophenyl)sulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-(m-tolylsulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-tosylpyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-(1-((4-methoxyphenyl)sulfonyl)pyrrolidine-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-((4-(trifluoromethyl)phenyl)sulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-(naphthalene-2-ylsulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-(piperidine-1-ylsulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (R)\u2014N-methyl-N-(1-(morpholinosulfonyl)pyrrolidine-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (S)-3-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)-3-oxopropanenitrile; (R)-3-((3-((7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)sulfonyl)benzonitrile; (R)-3-(3-(ethyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)-3-oxopropanenitrile; (R)-3-((3-(ethyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)sulfonyl)benzonitrile; (R)-3-(3-((cyclopropylmethyl)(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)-3-oxopropanenitrile; or (R)-3-((3-((cyclopropylmethyl)(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)pyrrolidine-1-yl)sulfonyl)benzonitrile.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 1.0
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15507409', '14183946', '13928696', '14715046', '13859569']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7820605240779067
- 35 USC 102 Novelty (BERT): 0.5645030959204129
- Combined Prediction Score: 0.7603047812621574
- Mean Citation Score: 368.18293400000016
- Max Citation Score: 425.25983
- Similarity Product: 379.8611077042103

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test