PATENT CLAIM ANALYSIS

Application Number: 15983209
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["506", "009000"]

Abstract:
The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use. In some embodiments, a reference scorecard can be compared with the test stem cell line scorecard to accurately predict the utility and/or identify specific characteristics of the stem cell line, e.g., to determine its suitability for downstream applications, e.g., therapeutic use, drug screening, toxicity assays, differentiation into a desired cell lineage, etc.

Claim (Index 15):
A kit comprising:\n a. the array of  claim 9 ; and b. reagents to carry out amplification of the mRNA of the at least 12 early developmental genes.

Metadata:
- Claim Count in Document: 30.0
- Percentile: 93.0
- Lexical Diversity: 2.01235
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14936774', '13114102', '12664763', '14439037', '13998974']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.575881883262844
- 35 USC 102 Novelty (BERT): 0.5339982123303384
- Combined Prediction Score: 0.5716935161695934
- Mean Citation Score: 351.49161200000015
- Max Citation Score: 374.56046
- Similarity Product: 250.6584061227095

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test