PATENT CLAIM ANALYSIS

Application Number: 15879294
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["424", "134100"]

Abstract:
Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic formulations include a stable liquid formulation and a lyophilizable formulation. Preferably, the protein antagonist has an amino acid sequence of SEQ ID NO:4.

Claim (Index 20):
A method of maintaining stability of a formulation, comprising the steps of:\n (a) adding a vascular endothelial growth factor (VEGF) antagonist to a solution at a concentration of from 1 mg/ml to 100 mg/ml, wherein the solution comprises:\n (i) an organic co-solvent; \n (ii) 5 mM to 40 mM of a phosphate buffer; and \n (iii) 1.0% to 10% of a stabilizing agent selected from the group consisting of sucrose, sorbitol, glycerol, trehalose, and mannitol; \n wherein the VEGF antagonist is a fusion protein comprising an immunoglobulin-like (Ig) domain 2 of a first VEGF receptor and Ig domain 3 of a second VEGF receptor, and a multimerizing component; and (b) maintaining the formulation over a period of time of from 1 month to 24 months whereby the formulation remain suitable for intravitreal administration.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 86.0
- Lexical Diversity: 1.23256
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15151776', '15095606', '13914996', '11818463', '12560885']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7832948102524918
- 35 USC 102 Novelty (BERT): 0.5991591924534767
- Combined Prediction Score: 0.7648812484725903
- Mean Citation Score: 511.176478
- Max Citation Score: 527.5613
- Similarity Product: 461.9387642658472

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test