PATENT CLAIM ANALYSIS

Application Number: 16075932
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "394000"]

Abstract:
The present invention is related to diagnostic, treatment and compound screening methods related to dry age-related macular degeneration (dry AM D). In select embodiments, the methods comprise determining expression or activity levels of NAD-dependent deacetylase sirtuin-1 (SI RT-1), AM P-activated protein kinase (AM PK), poly(adenosine diphosphate ribose) poly-merase-2 (PARP2), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-Iα) and/or mRNA levels of RAC-gamma serine/threonine-protein kinase (AKT3). In general, higher levels of PARP2, lower levels of PGC-Iα or AKT3 and/or higher acetylation levels of PGC-Iα in the samples are indicative that the subject or cells from which the samples are obtained are susceptible or are suffering from dry AMD.

Claim (Index 21):
A method of monitoring the progression of a treatment of dry age-related macular degeneration (dry AMD) in a subject, the method comprising\n a) analyzing at least two samples from a subject undergoing treatment for dry AMD with each sample taken at different time points to determine expression or activity levels of NAD-dependent deacetylase sirtuin-1 (SIRT-1) at the different time points, and b) comparing the values of the subject's expression or activity levels of SIRT-1 over time to determine if the subject's expression or activity levels of SIRT-1 are changing over time in response to the treatment, wherein a lack of change or a further deviation from normal expression or activity levels of SIRT-1 in the subject's expression or activity levels of SIRT-1 is indicative that the treatment for dry AMD is not effective, and wherein an approximation of the subject's expression or activity levels of SIRT-1 over time towards normal expression or activity levels of SIRT-1 is indicative that the treatment for dry AMD is effective in treating dry AMD in the subject.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 96.0
- Lexical Diversity: 1.71053
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12583073', '15485997', '14746221', '10773446', '11660986']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7612568424854134
- 35 USC 102 Novelty (BERT): 0.5110028240694156
- Combined Prediction Score: 0.7362314406438136
- Mean Citation Score: 258.177182
- Max Citation Score: 271.42883
- Similarity Product: 177.70991820718228

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test