PATENT CLAIM ANALYSIS

Application Number: 16069854
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "04400A"]

Abstract:
Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulations may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g. glioblastoma.

Claim (Index 8):
The method of  claim 6 , wherein the composition that modulates TLX activity is complexed with a nanoparticle.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.43137
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13447249', '13996114', '14363545', '14348365', '12936780']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7554236433130903
- 35 USC 102 Novelty (BERT): 0.5301770596849436
- Combined Prediction Score: 0.7328989849502756
- Mean Citation Score: 273.56248000000005
- Max Citation Score: 309.11072
- Similarity Product: 195.72641745105744

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test