PATENT CLAIM ANALYSIS

Application Number: 16354651
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "005100"]

Abstract:
The invention relates to growth hormone compounds with a protracted profile. The effect is obtained by linking an albumin binding residue via a hydrophilic spacer to growth hormone variants. Further described are methods of preparing and using such compounds. These growth hormone compounds are based on there althered profile considered particular useful in therapy.

Claim (Index 7):
The conjugate of  claim 2 , wherein B has the formula\n \u2014X 1 \u2014X 2 \u2014X 3 \u2014X 4 \u2014 wherein\n X 1  is \u2014W 1 \u2014[(CHR 1 ) l1 \u2014W 2 ] m1 \u2014{[(CH 2 ) n1 E1] m2 \u2014[(CHR 2 ) l2 \u2014W 3 ] m3 } n2 \u2014; \n X 2  is \u2014[(CHR 3 ) l3 \u2014W 4 ] m4 \u2014{[(CH 2 ) n3 E2] m5 \u2014[(CHR 4 ) l4 \u2014W 5 ] m6 } n4 \u2014, \n X 3  is \u2014[(CHR 5 ) l5 \u2014W 6 ] m7 \u2014; \n X 4  is F-D1-(CH 2 ) l6 -D2-; \n l1, l2, l3, l4, l5 and l6 independently are selected from 0-16, such as from 0-6 \n m1, m3, m4, m6 and m7 independently are selected from 0-10, such as from 0-6 \n m2 and m5 independently are selected from 0-25, such as from 0-10 \n n1, n2, n3 and n4 independently are selected from 0-16, such as from 0-10 \n F is aryl, hetaryl, pyrrolidine-2,5-dione or a valence bond, wherein the aryl and hetaryl groups are optionally substituted with halogen, \u2014CN, \u2014OH, \u2014C(O)OH, \u2014C(O)NH 2 , \u2014S(O) 2 OH or C 1-6 -alkyl; \n R 1 , R 2 , R 3 , R 4  and R 5  independently are selected from hydrogen, \u2014C(O)OH, \u2014C(O)NH 2 , \u2014S(O)OH, \u2014S(O) 2 OH, \u2014NH\u2014C(\u2550NH)\u2014NH 2 , C 1-6 -alkyl, aryl or hetaryl, wherein the alkyl, aryl and hetaryl groups optionally are substituted with halogen, \u2014C(O)OH, \u2014C(O)NH 2 , \u2014S(O)OH, \u2014S(O) 2 OH, \u2014CN or \u2014OH; \n D1, D2, E1 and E2 independently are selected from \u2014O\u2014, \u2014N(R 6 )\u2014, \u2014N(C(O)R 7 )\u2014 or a valence bond, wherein R 6  and R 7  independently represent hydrogen or C 1-6 -alkyl; \n W 1  to W 5  independently are selected from \u2014C(O)NH\u2014, \u2014NHC(O)\u2014, \u2014C(O)NHCH 2 \u2014, \u2014CH 2 NHC(O)\u2014, \u2014C(O)NHS(O) 2 \u2014, \u2014S(O) 2 NHC(O)\u2014, \u2014OC(O)NH\u2014, \u2014NHC(O)O\u2014, \u2014C(O)CH 2 \u2014, \u2014CH 2 C(O)\u2014, \u2014C(O)CH\u2550CH\u2014, \u2014CH\u2550CHC(O)\u2014, \u2014(CH 2 ) s2 \u2014, \u2014C(O)\u2014, \u2014C(O)O\u2014, \u2014OC(O)\u2014, or a valence bond, wherein s2 is 0 or 1; \n W 6  is selected from \u2014C(O)NH\u2014, \u2014NHC(O)\u2014, \u2014C(O)NHCH 2 \u2014, \u2014CH 2 NHC(O)\u2014, \u2014C(O)NHS(O) 2 \u2014, \u2014S(O) 2 NHC(O)\u2014, \u2014OC(O)NH\u2014, \u2014NHC(O)O\u2014, \u2014C(O)CH 2 \u2014, \u2014CH 2 C(O)\u2014, \u2014C(O)CH\u2550CH\u2014, \u2014CH\u2550CHC(O)\u2014, \u2014(CH 2 ) s1 \u2014, \u2014C(O)\u2014, \u2014C(O)O\u2014, \u2014OC(O)\u2014, \u2014NHC(O)C 1-6 -alkyl, \u2014C(O)NHC 1-6 -alkyl or a valence bond, wherein s1 is 0 or 1 and the C 1-6 -alkyl group is optionally substituted with oxo, pyrrolidine-2,5-dione, \u2014NHC(O)CH*CH 2 COOH or \u2014NHC(O)CH 2 CH*COOH, wherein (*) indicates the attachment point from the carbon atom of CH to X 4 .

Metadata:
- Claim Count in Document: 36.0
- Percentile: 99.0
- Lexical Diversity: 1.31818
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13522390', '14132919', '13144757', '13574128', '12990101']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7745852614796818
- 35 USC 102 Novelty (BERT): 0.6634080716390144
- Combined Prediction Score: 0.7634675424956151
- Mean Citation Score: 456.2411679999999
- Max Citation Score: 676.3252
- Similarity Product: 601.9862584189415

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test