PATENT CLAIM ANALYSIS

Application Number: 15925551
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "279000"]

Abstract:
The present disclosure relates to the preparation of polymorphic mixtures of Cepharanthine.2HCl. Mixtures of at least two polymorphic forms can be formed into a mobile liquid phase in organic/aqueous solvent mixtures along with enteric polymer that can be spray dried to produce solid particulate enteric formulations for medicinal drug-treatment applications.

Claim (Index 10):
A method of forming an enteric formulation of Cepharanthine.2HCl comprising:\n (a) supplying the dihydrochloride salt of Cepharanthine comprising Cepharanthine.2 HCl of the following formula: (b) recrystallizing said Cepharanthine.2HCl salt from an aliphatic alcohol/water mixture comprising 80-99 parts aliphatic alcohol and 1-20 parts water and recovering recrystallized Cepharanthine.2HCl salt comprising mixture of at least two polymorphs at a purity of \u226599.4%; (c) introducing said recrystallized Cepharanthine.2HCl in combination with a polymer into a mixture of a water soluble organic solvent/water mixture comprising water soluble organic solvent at a level of \u226585% by weight, to provide a liquid mobile phase; (c) forming a solid enteric formulation from said liquid mobile phase to produce an enteric particle containing an amorphous liquid crystal form of said Cepharanthine.2HCl salt at a particle size of 10 \u03bcm to 20 \u03bcm.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.2093
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11293678', '15863850', '12952879', '12105316', '11519756']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7212155372397975
- 35 USC 102 Novelty (BERT): 0.4811630504051475
- Combined Prediction Score: 0.6972102885563325
- Mean Citation Score: 152.16286599999995
- Max Citation Score: 156.41245
- Similarity Product: 105.92207599138024

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test