PATENT CLAIM ANALYSIS

Application Number: 16055921
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["424", "422000"]

Abstract:
A new method of targeted drug administration to wounds (surgical or traumatic), intrasite (IS), offers advantages in treatment efficacy and safety over traditional routes of administration. A novel method of dosing IS medications based on wound surface area provides the parameters for safe and effective dosing, a necessary advance for any FDA approval. Large IS doses increase risk of toxicity from impurities allowed in drugs given by other routes. Methods are presented for ultrapurification, particularly of endotoxins. Methods are presented for sterile delivery to the wound, to prevent aerosolization, and to homogenize application. Pharmacodynamic parameters make certain drugs advantageous as IS agents, including slow trans-wound surface diffusion, protein binding, and limited local tissue toxicity. Vancomycin is a prototypical drug with these features and is therefore very useful as an IS medication. Other drugs, including but not limited to rifaximin, possess similar pharmacodynamics and may be useful IS pharmaceuticals, delivered alone or in combination with other drugs, carriers, or materials. All of these attributes are advantages over traditional administration methods.

Claim (Index 96):
A method of treating a wound with vancomycin through intrasite administration, the method comprising:\n a) determining a surface area of the wound; b) calculating an effective dose of vancomycin for treating the wound based on the surface area of the wound, the effective dose of vancomycin being insufficient to cause a systemic toxic effect or side effect; and c) administering at least one of the effective dose of vancomycin through intrasite administration to the wound, wherein the effective dose inhibits or treats an infection of the wound.

Metadata:
- Claim Count in Document: 91.0
- Percentile: 96.0
- Lexical Diversity: 1.68966
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13566816', '15347949', '10500822', '14327192', '12758602']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6720074099246726
- 35 USC 102 Novelty (BERT): 0.4833265236242063
- Combined Prediction Score: 0.653139321294626
- Mean Citation Score: 147.862592
- Max Citation Score: 153.21283
- Similarity Product: 100.81777603936852

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test