PATENT CLAIM ANALYSIS

Application Number: 16026523
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["435", "007100"]

Abstract:
There is provided methods of determining tuberculosis (TB) infection status in an individual comprising: (i) providing a sample comprising T-cells; (ii) exposing the sample of (i) to one or more TB antigens; (iii) identifying T-cells in the sample that are CD4 positive and (a) secrete TNF-α without secreting IFN-γ; or (b) secrete IFN-γ without secreting TNF-α; (iv) identifying those cells of (iii) which are also CCR7 and, CD127 negative; and optionally (v) calculating the cells identified in (iv) as a percentage of those identified in (iii); wherein the identification of cells in (iv) and/or the percentage of T-cells calculated in (v) correlates to TB infection status of the individual, and wherein steps (iii) and (iv) can be carried out either sequentially or simultaneously. There are also provided compositions and kits for use in such methods.

Claim (Index 32):
The composition of  claim 31  wherein the plurality of antibodies or antigen-binding fragments thereof additionally binds to each of TNF-\u03b1 and IFN-\u03b3 and additionally comprises antibodies or antigen-binding fragments thereof that are individually specific for each of TNF-\u03b1 and IFN-\u03b3.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 95.0
- Lexical Diversity: 2.28205
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14916632', '13996649', '15309403', '14660484', '13240009']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6574260556639021
- 35 USC 102 Novelty (BERT): 0.6398083446971026
- Combined Prediction Score: 0.6556642845672221
- Mean Citation Score: 498.955654
- Max Citation Score: 965.4139
- Similarity Product: 558.4534185412526

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test