PATENT CLAIM ANALYSIS

Application Number: 15780231
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "300000"]

Abstract:
The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Claim (Index 1):
A compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein\n each R 1  and R 3  is independently H, F, Cl, Br, CN, NO 2 , \u2014C(\u2550O)R a , \u2014C(\u2550O)OR b , \u2014C(\u2550O)NR c R d , OR b , \u2014NR c R d , R b O\u2014C 1-4  alkylene, R d R c N\u2014C 1-4  alkylene, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-8  cycloalkyl, C 3-8  cycloalkyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 10-membered heteroaryl or (5- to 10-membered heteroaryl)-C 1-4  alkylene, and wherein each of the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-8  cycloalkyl, C 3-8  cycloalkyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 10-membered heteroaryl and (5- to 10-membered heteroaryl)-C 1-4  alkylene is independently unsubstituted or substituted with one, two, three or four substituents independently selected from F, Cl, Br, CN, OR b , \u2014NR c R d , C 1-6  alkyl, C 1-6  haloalkyl, R b O\u2014C 1-4  alkylene or R d R c N\u2014C 1-4  alkylene; \n n is 0, 1, 2 or 3; \n each R 2  is independently F, C 2-6  alkynyl, OR b , C 3-12  carbocyclyl, C 3-12  carbocyclyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 14-membered heteroaryl, (5- to 14-membered heteroaryl)-C 1-4  alkylene; or two adjacent R 2 , together with the atoms to which they are attached, form a C 3-12  carbocyclic ring, 3- to 12-membered heterocyclic ring, C 6-10  aromatic ring or or 5- to 10-membered heteroaromatic ring, and wherein each of the C 2-6  alkynyl, C 3-12  carbocyclyl, C 3-12  carbocyclyl-C 1-4  alkylene, 3- to 12-membered heterocyclyl, (3- to 12-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 14-membered heteroaryl, (5- to 14-membered heteroaryl)-C 1-4  alkylene, C 3-12  carbocyclic ring, 3- to 12-membered heterocyclic ring, C 6-10  aromatic ring and 5- to 10-membered heteroaromatic ring is independently unsubstituted or substituted with one, two, three, four or five R\u2032, with the proviso that when m is 1, R 2  is not F; \n each R\u2032 is independently F, Cl, Br, CN, NO 2 , \u2550O, OR b , \u2014NR c R d , R b O\u2014C 1-4  alkylene, R d R c N\u2014C 1-4  alkylene, \u2014C(\u2550O)R a , \u2014C(\u2550O)OR b , \u2014C(\u2550O)NR c R d , C 1-10  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-4  alkylene, 3- to 6-membered heterocyclyl, (3- to 6-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 6-membered heteroaryl or (5- to 6-membered heteroaryl)-C 1-4  alkylene, and wherein each of the C 1-10  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-4  alkylene, 3- to 6-membered heterocyclyl, (3- to 6-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 6-membered heteroaryl and (5- to 6-membered heteroaryl)-C 1-4  alkylene is independently unsubstituted or substituted with one, two, three, or four substituents independently selected from F, Cl, Br, CN, NO 2 , OR b , \u2014NR c R d , C 1-6  alkyl, C 1-6  haloalkyl, R b O\u2014C 1-4  alkylene or R d R c N\u2014C 1-4  alkylene; \n m is 1 or 2; \n X has one of the following sub-formulae: \n wherein R 4  is H or C 1-6  alkyl, and wherein the C 1-6  alkyl is optionally substituted with one, two, three, or four U; each R 5 , R 6 , R 7  and R 8  is independently H or C 1-6  alkyl; or R 5  and R 6 , together with the carbon atom to which they are attached, form a C 3-8  cycloalkyl group, 3- to 6-membered heterocyclic ring, C 6-10  aromatic ring or 5- to 10-membered heteroaromatic ring; or R 7  and R 8 , together with the nitrogen atom to which they are attached, form a 3- to 6-membered heterocyclic ring or 5- to 10-membered heteroaromatic ring, and wherein each C 1-6  alkyl, C 3-8  cycloalkyl, 3- to 6-membered heterocyclic ring, C 6-10  aromatic ring or 5- to 10-membered heteroaromatic ring is independently unsubstituted or substituted with one, two, three, or four U; W is a C 3-12  carbocyclic ring or 3- to 12-membered heterocyclic ring; each V and V\u2032 is independently a C 3-12  cycloalkane ring, 3- to 12-membered heterocyclic ring, C 6-10  aromatic ring or 5- to 10-membered heteroaromatic ring; each R w  is independently F, Cl, Br, CN, NO 2 , \u2550O, \u2014C(\u2550O)R a , \u2014C(\u2550O)OR b , \u2014C(\u2550O)NR c R d , \u2014S(\u2550O) 2 R e , \u2014S(\u2550O) 2 NR c C(\u2550O)R a , \u2014S(\u2550O) 2 NR c R d , (R b O) 2 P(\u2550O)\u2014C 0-2  alkylene, OR b , \u2014NR c R d , R b O\u2014C 1-2  alkylene, R d R c N\u2014C 1-2  alkylene, C 1-6  alkyl, 5- to 6-membered heteroaryl or 5- to 6-membered heterocyclyl, and wherein each of the C 1-6  alkyl, 5- to 6-membered heteroaryl or 5- to 6-membered heterocyclyl is independently unsubstituted or substituted with one, two, three, or four U; each U is independently F, Cl, Br, NO 2 , CN, \u2550O, N 3 , OR b , \u2014NR c R d , C 1-6  alkyl or C 1-6  haloalkyl; each s and t is independently 0, 1, 2 or 3; p is 1, 2 or 3; and each R a , R b , R c , R d  and R e  is independently H, C 1-6  alkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-4  alkylene, 3- to 6-membered heterocyclyl, (3- to 6-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 10-membered heteroaryl, (5- to 10-membered heteroaryl)-C 1-4  alkylene; or R c  and R d , together with the nitrogen atom to which they are attached, form a 3- to 6-membered heterocyclic ring, and wherein each of the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-4  alkylene, 3- to 6-membered heterocyclyl, (3- to 6-membered heterocyclyl)-C 1-4  alkylene, C 6-10  aryl, C 6-10  aryl-C 1-4  alkylene, 5- to 10-membered heteroaryl, (5- to 10-membered heteroaryl)-C 1-4  alkylene and 3- to 6-membered heterocyclic ring is independently unsubstituted or substituted with one, two, three, or four substituents independently selected from F, Cl, CN, OH, NH 2 , C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy or C 1-6  alkylamino.

Metadata:
- Claim Count in Document: 30.0
- Percentile: 93.0
- Lexical Diversity: 1.48148
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16326189', '16327335', '15577771', '15300284', '12728153']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8276838403380821
- 35 USC 102 Novelty (BERT): 0.573215614814274
- Combined Prediction Score: 0.8022370177857013
- Mean Citation Score: 404.142608
- Max Citation Score: 471.80267
- Similarity Product: 403.1183995460701

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test