PATENT CLAIM ANALYSIS

Application Number: 16094826
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["514", "237200"]

Abstract:
The present invention relates to a novel N-acylurea derivative and the use thereof for the prevention or treatment of cardiovascular disease, and more particularly to a novel N-acylurea derivative, a pharmaceutical composition for prevention or treatment of cardiovascular disease, which contains the N-acylurea derivative as an active ingredient, and a method of preparing the N-acylurea derivative. The N-acylurea derivative according to the present invention can inhibit platelet aggregation by inhibiting the activity of talin in the intracellular matrix, and thus can be useful for the prevention or treatment of cardiovascular disease.

Claim (Index 5):
The compound or the pharmaceutically acceptable salt thereof of  claim 1 , wherein the compound is selected from the group consisting of:\n (1) N-((4-bromo-3-methoxyphenl) carbamoyl)-2-(5-phenyl-2H-tetrazol-2-yl)acetamide; (2) N-((4-phenoxyphenyl)carbamoyl)-2-(5-phenyl-2H-tetrazol-2-yl)acetamide; (3) N-((4-methoxybenzyl)carbamoyl)-2-(5-phenyl-2H-tetrazol-2-yl)acetamide; (4) N-((2-(3a, 7a-dihydro-1H-indol-3-yl)ethyl)carbamoyl)-2-(5-phenyl-2H-tetrazol-2-yl)acetamide); (5) N-((2,4-dimethoxyphenyl)carbamoyl)-2-(5-phenyl-2H-tetrazol-2-yl)acetamide; (6) N-((4-(benzyloxy)phenyl)carbamoyl)-2-(5-phenyl-2H-tetrazol-2-yl)acetamide; (7) N-((2-fluorophenyl)carbamoyl)-2-(5-phenyl-2H-tetrazol-2-yl)acetamide; (8) 2-(benzo[d][1,3]dioxol-5-yloxy)-N-((3-fluoropyridin-2-yl)carbamoyl)acetamide; (9) 2-(benzo[d][1,3]dioxol-5-yloxy)-N-((4-bromo-3-methoxyphenyl)carbamoyl)acetamide; (10) 2-(benzo[d][1,3]dioxol -5-yloxy)-N-((4-phenoxyphenyl)carbamoyl)acetamide; (11) 2-(benzo[d][1,3]dioxol -5-yloxy)-N-((4-methoxybenzyl)carbamoyl)acetamide; (12) N-((2-(1H-indol-3-yl)ethyl)carbamoyl)-2-(benzo[d][1,3]dioxol-5-yloxy)acetamide; (13) 2-(benzo[d][1,3]dioxol-5-yloxy)-N-((2,4-dimethoxyphenyl)carbamoyl)acetamide; (14) 2-(benzo[d][1,3]dioxol-5-yloxy)-N-((4-(benzyloxy)phenyl)carbamoyl)acetamide; (15) 2-(benzo[d][1,3]dioxol-5-yloxy)-N-((2-fluorophenyl)carbamoyl)acetamide; (16) N-((3-fluoropyridin-2-yl)carbamoyl)-2-(2-methoxyphenoxy)acetamide; (17) N-((4-bromo-3-methoxyphenyl)carbamoyl)-2-(2-methoxyphenoxy)acetamide; (18) 2-(2-methoxyphenoxy)-N-((4-phenoxyphenyl)carbamoyl)acetamide; (19) N-((4-methoxybenzyl)carbamoyl)-2-(2-methoxyphenoxy)acetamide; (20) N-((2-(1H-indol-3-yl)ethyl)carbamoyl)-2-(benzo[d][1,3]dioxol-5-yloxy)acetamide; (21) N-((2,4-dimethoxyphenyl)carbamoyl)-2-(2-methoxyphenoxy)acetamide; (22) N-((4-(benzyloxy)phenyl)carbamoyl)-2-(2-methoxyphenoxy)acetamide; (23) N-((2-fluorophenyl)carbamoyl)-2-(2-methoxyphenoxy)acetamide; (24) 2-(3,5-bis(trifluoromethyl)phenoxy)-N-((3-fluoropyridin-2-yl)carbamoyl)acetamide; (25) 2-(3,5-bis(trifluoromethyl)phenoxy)-N-((4-bromo -3-methoxyphenyl)carbamoyl)acetamide; (26) 2-(3,5-bis(trifluoromethyl)phenoxy)-N-((4-bromo -3-methoxyphenyl)carbamoyl)acetamide; (27) 2-(3,5-bis(trifluoromethyl)phenoxy)-N-((4-methoxybenzyl)carbamoyl)acetamide; (28) N-((2-(1H-indol-3-yl)ethyl)carbamoyl)-2-(3,5-bis (trifluoromethyl)phenoxy)acetamide; (29) 2-(3,5-bis(trifluoromethyl)phenoxy)-N-((2,4-dimethoxyphenyl)carbamoyl)acetamide; (30) N-((4-(benzyloxy)phenyl)carbamoyl)-2-(3,5-bis(trifluoromethyl)phenoxy)acetamide; (31) 2-(3,5-bis(trifluoromethyl)phenoxy)-N-((2-fluorophenyl)carbamoyl)acetamide; (32) N-((4-bromo-3-methoxyphenyl)carbamoyl)-2-(3-bromophenoxy)acetamide; (33) 2-(3-bromophenoxy)-N-((2,4-dimethoxyphenyl)carbamoyl)acetamide; (34) 2-(2,3-dimethylphenoxy)-N-((2-fluorophenyl)carbamoyl)acetamide; (35) 2-(4-(benzyloxy)phenoxy)-N-((2-fluorophenyl)carbamoyl)acetamide; (36) N-((2-fluorophenyl)carbamoyl)-2-morpholinoacetamide; and (37) tert-butyl 4-(2-(3-(2-fluorophenyl)ureido)-2-oxoethyl)piperazine-1-carboxylate.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 97.0
- Lexical Diversity: 2.0
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11735751', '11937159', '13003558', '15311817', '14112735']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8150896807960626
- 35 USC 102 Novelty (BERT): 0.4948987699945784
- Combined Prediction Score: 0.7830705897159141
- Mean Citation Score: 264.835466
- Max Citation Score: 268.83524
- Similarity Product: 225.41245812408448

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test