PATENT CLAIM ANALYSIS

Application Number: 16281725
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "004800"]

Abstract:
A backbone N-methylation approach on SHU9119, a non-selective cyclic peptide antagonist at hMC3R and hMC4R. Systematic N-methylated derivatives of SHU9119, with all possible backbone N-methylation combinations have been synthesized and examined for their binding and functional activities towards melanocortin receptor subtypes 1, 3, 4 and 5 (hMCRs). Several N-methylated analogues, which have selective and potent agonists or antagonists activity for the hMC1R or hMC5R or selective antagonist activity for the hMC3R, are discovered from the library. The selective hMC1R ligands show strong binding for human melanoma cells. The first universal antagonist for all subtypes of hMCRs will be of critical importance to modulate the melanocortin system with endogenous agonists.

Claim (Index 2):
The method of  claim 1 , wherein the modified melanocortin receptor modulator is a selective human melanocortin 1 (hMC1) receptor agonist.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 99.0
- Lexical Diversity: 1.5641
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13074565', '11174845', '14058790', '10640755', '15289562']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7962018130987002
- 35 USC 102 Novelty (BERT): 0.5486807917189102
- Combined Prediction Score: 0.7714497109607212
- Mean Citation Score: 384.694172
- Max Citation Score: 399.55542
- Similarity Product: 267.1733656551504

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test