PATENT CLAIM ANALYSIS

Application Number: 15753734
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["536", "026800"]

Abstract:
Provided in the present disclosure are a novel preparation method of nucleoside phosphoramidate prodrugs and the intermediates thereof. In particular, the method is adopted to perform isomer separation on the reaction product from a first step and then perform a two-step chemical synthesis, so as to prepare a high-purity compound S p -1. The method has simple and convenient operation and low cost. The prepared resulting single isomer S p -1 has high purity, and the HPLC purity thereof is 95% or more, and further, 99% or more. The method is suitable for industrial production and can satisfy the need of clinical study. Further, also provided in the present disclosure are a key intermediate phosphorus reagent for preparing the high-purity compound S p -1 and the preparation method thereof.

Claim (Index 1):
A method of preparing a compound S p -1, wherein the method comprises reacting a compound 61501c with a compound 61501b to produce a compound 61501a: wherein R is H or a hydroxyl protecting group; L is a leaving group; optionally, when R is not H, the hydroxyl protecting group of the compound 61501a is deprotected to give the compound S p -1.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 88.0
- Lexical Diversity: 1.76543
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15754009', '15754318', '12296223', '14063868', '12778797']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.604541913490578
- 35 USC 102 Novelty (BERT): 0.4976160903876209
- Combined Prediction Score: 0.5938493311802823
- Mean Citation Score: 237.325336
- Max Citation Score: 279.132
- Similarity Product: 233.5725274271965

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test