PATENT CLAIM ANALYSIS

Application Number: 15742093
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "04400A"]

Abstract:
Aspects of the invention relate to methods for treating ALS comprising administering to a subject in need thereof a therapeutically effective amount of a nucleic acid molecule that is directed against a gene encoding superoxide dismutase 1 (SOD1).

Claim (Index 1):
An isolated double stranded nucleic acid molecule directed against superoxide dismutase 1 (SOD1) comprising a guide strand and a passenger strand, wherein the isolated double stranded nucleic acid molecule includes a double stranded region and a single stranded region, wherein the region of the molecule that is double stranded is from 8-15 nucleotides long, wherein the guide strand contains a single stranded region that is 2-14 nucleotides long, wherein the guide strand contains 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 or 22 phosphorothioate modifications, wherein the passenger strand is 8 to 15 nucleotides long, wherein the passenger strand contains 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 phosphorothioate modifications, wherein at least 40% of the nucleotides of the isolated double stranded nucleic acid molecule are modified, and wherein the isolated double stranded nucleic acid molecule comprises at least 12 contiguous nucleotides of a sequence selected from the sequences within Tables 1-8, including the modification pattern provided in Tables 1-8.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 86.0
- Lexical Diversity: 1.13889
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13636755', '13636728', '14729006', '15099481', '14728653']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8422951726752406
- 35 USC 102 Novelty (BERT): 0.6261743600667615
- Combined Prediction Score: 0.8206830914143927
- Mean Citation Score: 498.6139359999999
- Max Citation Score: 534.2475
- Similarity Product: 416.53420087516304

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test