PATENT CLAIM ANALYSIS

Application Number: 15983423
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["514", "212070"]

Abstract:
The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.

Claim (Index 17):
A compound selected from the group consisting of: 5-(4-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)-1,3,4-oxadiazole-2-thiol; 8-methoxy-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(4-(4-morpholinopiperidin-1-yl)phenyl)-2H-pyrazolo[3,4-c]quinolin-4-amine; N5-(8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)-N2,N2-dimethylpyridine-2,5-diamine; 9-methyl-N-(3-(methylsulfonyl)phenyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methyl-N-(4-morpholinophenyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(3-(methylsulfonyl)-4-morpholinophenyl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-(5-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)pyridin-2-yl)piperazin-1-yl)ethan-1-one; 9-(methylsulfonyl)-N-(4-morpholinophenyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-(4-((9-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)piperazin-1-yl)ethan-1-one; (4-((9-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl) (morpholino)methanone; N-(4-(4-(tert-butyl)piperazin-1-yl)phenyl)-9-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(6-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)pyridin-3-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; N-(4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-9-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-((9-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one; N-(3,4-dimethoxyphenyl)-9-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-9-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 7-(methylsulfonyl)-N-(4-morpholinophenyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methoxy-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-(methylsulfonyl)-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1,5-dimethyl-1H-pyrazol-4-yl)-8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-amine; N-(1,3-dimethyl-1H-pyrazol-4-yl)-8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-amine; 2-((4-((9-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)amino)ethan-1-ol; 9-(methylsulfonyl)-N-(3-(methylsulfonyl)phenyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-(methylsulfonyl)-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-(methylsulfonyl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-(4-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)piperidin-1-yl)ethan-1-one; N-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-(4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)piperidin-1-yl)ethan-1-one; 9-methoxy-N-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-(4-((9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)piperidin-1-yl)ethan-1-one; 9-methoxy-N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-((7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one; 7-(methylsulfonyl)-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-methyl-1H-1,2,3-triazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(2-methyl-2H-1,2,3-triazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-methyl-1H-pyrazol-3-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 2-(4-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)-2-methylpropanamide; 8-methoxy-N-(2-methyl-2H-tetrazol-5-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-methyl-1H-imidazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-(4-((7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)piperidin-1-yl)ethan-1-one; 7-(methylsulfonyl)-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-7-(methylthio)-3H-pyrazolo[3,4-c]quinolin-4-amine; 2-methyl-2-(4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)propanenitrile; 8-(methylsulfonyl)-N-(1-(oxetan-3-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; (2-fluoro-4-((7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)(morpholino)methanone; (2-fluoro-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl) (morpholino)methanone; 4-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)pyridin-2 (H)-one; 4-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1-methylpyridin-2(1H)-one; N-(1-(3-methoxypropyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)cyclohexanecarbonitrile; N-(1-isopropyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(tert-butyl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methoxy-N-(1-(3-methoxypropyl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 2-(4-((9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)-2-methylpropanenitrile; 1-(4-((9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)cyclohexanecarbonitrile; 2-(4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol; N-(1-isobutyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(tert-butyl)-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(3-methoxypropyl)-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 2-methyl-2-(4-((7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)propanenitrile; N-(1-isobutyl-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 2-(4-((7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol; (3-methoxy-4-((7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl) (morpholino)methanone; N-(1-(tert-butyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; (3-methoxy-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl) (morpholino)methanone; N-(1-cyclopropyl-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isobutyl-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 2-(4-((9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol; (3-methoxy-4-((9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl) (morpholino)methanone; N-(1-cyclopropyl-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-methyl-3-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)pyridin-2(1H)-one; N-(1-cyclopropyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methoxy-N-(1-(1-methoxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methoxy-N-(1-(2-methoxyethyl)-3-methyl-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-(tert-butyl)piperidin-4-yl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methoxy-N-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-methoxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-methoxyethyl)-3-methyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-methoxyethyl)-5-methyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-(tert-butyl)piperidin-4-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(tert-butyl)-1H-pyrazol-3-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-5-methyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-5-methyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-5-methyl-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-5-methyl-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-3-methoxy-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-(tert-butyl)piperidin-4-yl)-3-methoxy-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-3-methoxy-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-5-methoxy-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-(tert-butyl)piperidin-4-yl)-3-methoxy-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-(tert-butyl)piperidin-4-yl)-5-methoxy-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(2-chloro-5-(methylsulfonyl)thiophen-3-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(3-methoxy-1-(3-methoxypropyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-methoxy-1-(3-methoxypropyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-chloro-1-isopropyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-3,5-dimethyl-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-chloro-1-(3-methoxypropyl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methoxy-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-chloro-1-(3-methoxypropyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-3,5-dimethyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 3-(3-methoxy-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)oxazolidin-2-one; N-(5-chloro-1-(2-methoxyethyl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-chloro-1-(2-methoxyethyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-chloro-1-(2-methoxyethyl)-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-5-methyl-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 6-((9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione; 1-isopropyl-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-3-carbonitrile; 1-isopropyl-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-5-carbonitrile; 1-(2-methoxyethyl)-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-3-carbonitrile; 1-(2-methoxyethyl)-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-5-carbonitrile; 1-isopropyl-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-3-carboxamide; 1-isopropyl-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-5-carboxamide; 1,3-dimethyl-6-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)pyrimidine-2,4(1H,3H)-dione; N-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-chloro-1-(piperidin-4-yl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-((9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol; 9-methoxy-N-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methoxy-N-(1-(2-methylallyl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methoxy-N-(1-(2-methylprop-1-en-1-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1,2-dimethyl-1H-imidazol-5-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-(methylsulfonyl)-N-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 2-methyl-1-(4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)propan-2-ol; N-(1-(2-methylprop-1-en-1-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-methylallyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-isopropyl-4-((9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-5-carboxamide; 9-methoxy-N-(1-(2-methoxyethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 9-methoxy-N-(1-(2-methoxyethyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-fluoroethyl)-3-methyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-fluoroethyl)-5-methyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-methoxyethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-methoxyethyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-(2-methoxyethyl)-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-5-carbonitrile; 1-(2-methoxyethyl)-4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-3-carbonitrile; N-(5-bromo-1-(2-methoxyethyl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-fluoro-1-(2-methoxyethyl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N4-(9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)-1-(2-methoxyethyl)-N5,N5-dimethyl-1H-pyrazole-4,5-diamine; N-(2-isopropyl-1-methyl-1H-imidazol-5-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(5-bromo-1-(2-methoxyethyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-(2-methoxyethyl)-N5,N5-dimethyl-N4-(8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)-1H-pyrazole-4,5-diamine; N-(5-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-methoxyethyl)-5-methyl-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(2-methyl-3-morpholinophenyl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(2-isopropyl-1-methyl-1H-imidazol-5-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isobutyl-1H-pyrazol-4-yl)-8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(tert-butyl)-1H-pyrazol-4-yl)-8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-(3-methoxypropyl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 6,8-dimethoxy-N-(4-morpholinophenyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 6,8-dimethoxy-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 6,8-dimethoxy-N-(1-(3-methoxypropyl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-fluoroethyl)-1H-pyrazol-4-yl)-8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-1H-pyrazol-4-yl)-8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-cyclopropyl-1H-pyrazol-4-yl)-8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-1H-pyrazol-4-yl)-6,8-dimethoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-(tert-butyl)piperidin-4-yl)-1H-pyrazol-4-yl)-6,8-dimethoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-((8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)piperidin-4-ol; 2-(4-(4-((8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)piperazin-1-yl)ethan-1-ol; 1-(4-((8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol; N-(1-(tert-butyl)-1H-pyrazol-4-yl)-8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1-(tert-butyl)piperidin-4-yl)-1H-pyrazol-4-yl)-8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 2-(4-((8-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)-2-methylpropanenitrile; N-(3,4-dimethoxyphenyl)-7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 2-(4-(4-((7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)piperazin-1-yl)ethan-1-ol; 6-methoxy-N-(4-morpholinophenyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-isopropyl-1H-pyrazol-4-yl)-6-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 6-methoxy-N-(1-(3-methoxypropyl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 6-methoxy-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine; (4-((6,8-dimethoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl) (morpholino)methanone; 2-(4-(4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)piperazin-1-yl)ethan-1-ol; N-(1-(1-(tert-butyl)piperidin-4-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 2-(4-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)-N,N-dimethylacetamide; 8-methoxy-N-(1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(1,3-dimethoxypropan-2-yl)-1H-pyrazol-4-yl)-8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(2-methoxy-2-methylpropyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-amine; 1-(4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)piperidin-4-ol; 2-methyl-1-(4-((8-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)propan-2-ol; 4-ethyl-6-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-2H-benzo[b][1,4]oxazin-3(4H)-one; 8-methoxy-N-(1-(pyridin-2-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 8-methoxy-N-(1-(3-methylbutan-2-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 6-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one; 8-(methylsulfonyl)-N-(1-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; N-(1-(3-methylbutan-2-yl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 2-methyl-1-(3-methyl-4-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)propan-2-ol; 2-methyl-1-(5-methyl-4-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)propan-2-ol; 8-(methylsulfonyl)-N-(1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 4-methyl-6-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-2H-benzo[b][1,4]oxazin-3(4H)-one; 2-methyl-1-(4-((7-(methylsulfonyl)-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)propan-2-ol; 8-(methylsulfonyl)-N-(1-(pentan-3-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; N-(3-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)acetamide; N-(2-methoxy-5-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)acetamide; N-(3-ethylphenyl)-8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 2-(4-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)propanoic acid; 5-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazole-3-carboxylic acid; 2-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenol; (S)\u2014N-(3-(2-methylpyrrolidin-1-yl)phenyl)-8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-amine; (S)-8-methoxy-N-(3-(2-methylpyrrolidin-1-yl)phenyl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 2-(4-((9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)-N,N-dimethylacetamide; N-(1-(1,3-dimethoxypropan-2-yl)-1H-pyrazol-4-yl)-9-methoxy-3H-pyrazolo[3,4-c]quinolin-4-amine; 8-(methylsulfonyl)-N-(1-(pyridin-2-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 4-ethyl-6-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-2H-benzo[b][1,4]oxazin-3(4H)-one; 6-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-2H-benzo[b][1,4]oxazin-3(4H)-one; 6-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-2H-benzo[b][1,4]thiazin-3(4H)-one; 7-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-3,4-dihydroquinolin-2(1H)-one; N1-(8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)benzene-1,2-diamine; 2-(4-((8-methoxy-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-1H-pyrazol-1-yl)propanoic acid; 7-bromo-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 4-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenol; cyclopropyl(7-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-3,4-dihydroquinolin-1(2H)-yl)methanone; 4,5-dimethoxy-N1-(8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)benzene-1,2-diamine; N-(2-(4-acetylpiperazin-1-yl)-5-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)phenyl)acetamide; N-(1-((1R,2S)-2-methoxycyclohexyl)-1H-pyrazol-4-yl)-8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-amine; 5-((8-(methylsulfonyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)amino)-2-morpholinobenzonitrile; and 6-bromo-N-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-3H-pyrazolo[3,4-c]quinolin-4-amine.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.6087
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14436152', '14436145', '13506509', '13506510', '13509442']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8720343815359162
- 35 USC 102 Novelty (BERT): 0.6564700534614102
- Combined Prediction Score: 0.8504779487284656
- Mean Citation Score: 565.8482339999998
- Max Citation Score: 663.3793
- Similarity Product: 619.6200006148815

Labels:
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- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

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