PATENT CLAIM ANALYSIS

Application Number: 15753552
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA. The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.

Claim (Index 49):
A method for selecting an IMEF-Substrate from among a library of compounds; said method comprising:\n (i) in the presence of phloretin (100-1000 \u03bcM), and/or 6-KC (10-100 \u03bcM), incubating cells or liposomes with a candidate compound suspected of being an IMEF-Substrate from the library of compounds, (ii) measuring uptake levels of the candidate compound across membranes of and into the cells or liposomes, in the presence of phloretin and/or 6-KC; (iii) in the absence of phloretin and/or 6-KC (10-100 \u03bcM), incubating cells or liposomes with the candidate compound; (iv) measuring uptake levels of the candidate compound across membranes of and into the cells or liposomes, in the absence of phloretin and/or 6-KC; and (v) comparing the uptake levels of the candidate compound between the presence and the absence of phloretin and/or 6-KC; wherein a decrease in uptake of over 50% in the presence of phloretin; or an increase in uptake of over two-fold in the presence of 6-KC, indicates that the candidate compound is an IMEF-Substrate.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 88.0
- Lexical Diversity: 1.66102
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15222559', '14872179', '14830799', '15691821', '14690499']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8161523394178916
- 35 USC 102 Novelty (BERT): 0.5655823109036293
- Combined Prediction Score: 0.7910953365664654
- Mean Citation Score: 441.934864
- Max Citation Score: 574.69934
- Similarity Product: 323.6447699431467

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test