PATENT CLAIM ANALYSIS

Application Number: 16185020
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["424", "450000"]

Abstract:
A liposomal paclitaxel palmitate formulation, including: 0.1-1% (w/v) of a paclitaxel palmitate; 1-10% (w/v) of a lecithin; 0.05-1.0% (w/v) of distearoyl phosphoethanolamine-polyethylene glycol 2000 (DSPE-PEG2000); and water. A method for preparing the formulation includes: mixing the paclitaxel palmitate, lecithin, cholesterol, DSPE-PEG2000, and an organic solvent, and heating the resulting mixture at 25-75° C. to yield an organic phase; heating an aqueous phase to 25-75° C., and stirring and adding the organic phase to the aqueous phase, to yield a crude liposome; emulsifying the crude liposome, to yield a liposome solution; adding a cryoprotector to the liposome solution, adding water to the liposome solution to reach a preset calibration, adding a pH modifier, filtering the liposome solution, and packaging.

Claim (Index 11):
The formulation of  claim 4 , wherein the pH modifier is selected from the group consisting of citric acid, hydrochloric acid, sodium hydroxide, phosphoric acid, disodium hydrogen phosphate, sodium dihydrogen phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, disodium citrate, tri sodium citrate, or a mixture thereof.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 98.0
- Lexical Diversity: 2.4918
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15300688', '14765620', '10703187', '12741364', '14650355']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7753655620395103
- 35 USC 102 Novelty (BERT): 0.5171140767704925
- Combined Prediction Score: 0.7495404135126086
- Mean Citation Score: 260.81592
- Max Citation Score: 296.661
- Similarity Product: 186.44331776386505

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test