PATENT CLAIM ANALYSIS

Application Number: 16212914
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["073", "864830"]

Abstract:
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

Claim (Index 10):
A method of injecting a sample into a chromatography column of a liquid chromatography system, the liquid chromatography system comprising the chromatography column and an injection valve, the method comprising:\n isolating a sample loop of the liquid chromatography system from a high-pressure fluidic path in fluid communication with the chromatography column, wherein the high-pressure fluidic path is at a pump pressure, wherein the sample loop is in fluid communication with the injection valve and the sample loop comprises a sample conveying device for loading the sample on the sample loop, and the isolating of the sample loop comprises placing the injection valve in a PRESSURE COMPENSATION position, wherein the sample conveying device comprises a pump volume and a plunger, in which the plunger is guided in the pump volume;\n calculating a distance for a movement of the plunger within the pump volume from a first position to a second position to increase a pressure in the sample loop from an atmospheric pressure to the pump pressure based on a) a compressibility of a fluid in the sample conveying device and the sample loop, b) the pump pressure, and c) an elasticity of the sample loop; \n loading the sample on the sample loop; \n with the sample loaded on the sample loop and with the sample loop remaining isolated from the high-pressure fluidic path, forwarding the plunger within the pump volume by the calculated distance for the movement of the plunger within the pump volume from the first position to the second position to increase the pressure in the sample loop from the atmospheric pressure to the pump pressure, wherein the sample conveying device and the sample loop are in fluid communication in each position of the injection valve; and \n connecting the sample loop to the high-pressure fluidic path so that the pump pressure from a high-pressure pump is applied to the sample loop to cause the sample in the sample loop to flow from the sample loop through a portion of the high-pressure fluidic path to the chromatography column.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 98.0
- Lexical Diversity: 2.47692
- Patent Class: 73.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15596738', '12863976', '15959848', '15190570', '15190529']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7137927578628854
- 35 USC 102 Novelty (BERT): 0.5825094890907001
- Combined Prediction Score: 0.7006644309856669
- Mean Citation Score: 383.3975400000001
- Max Citation Score: 471.06497
- Similarity Product: 451.3126168238056

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test