PATENT CLAIM ANALYSIS

Application Number: 15897796
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["544", "106000"]

Abstract:
Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

Claim (Index 1):
A compound, having a formula or a salt thereof, wherein:\n Z is R 1 L 1 C(O)\u2014, or a carboxyl bioisostere; \n R 1  is hydrogen, aliphatic, \u2014OR 1A , \u2014NR 1A R 1B , \u2014C(O)R 1A , \u2014S(O) 2 R 1A , \u2014C(O)OR 1A , \u2014S(O) 2 NR 1A R 1B  or \u2014C(O)NR 1A R 1B ; \n each of R 1A , R 1B  R 3a  and R 3b  independently is hydrogen or aliphatic; \n L 1  is a bond or \u2014NR 30 \u2014, where R 30  is H; \n L 2  is a bond, aliphatic, heteroaliphatic, arylene, heteroarylene, cycloalkylene, or heterocycloalkylene; \n X is O; \n ring A is selected from a cycloalkylene, heterocycloalkylene, arylene or heteroarylene; \n ring B is selected from a cycloalkylene, heterocycloalkylene, arylene or heteroarylene; \n each R 2  independently is halogen, aryl, heteroaryl, aliphatic, heteroaliphatic, cyano, NO 2 , OH, or amino or two adjacent R 2  groups form a fused ring system with ring B; \n one L 3  is \u2014C(O)\u2014, and the other L 3  is a bond or aliphatic; \n L 4  is selected from a bond, aliphatic, heteroaliphatic, arylene, heteroarylene, cycloalkylene, or heterocycloalkylene; \n R 3  is selected from \u2014OH, \u2014OR 3A , \u2014NR 3A R 3B , \u2014C(O)R 3A , \u2014S(O) 2 R 3A , \u2014C(O)OR 3A , \u2014S(O) 2 NR 3A R 3B , or \u2014C(O)NR 3A R 3B , aliphatic, heteroaliphatic, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; \n each R 22  independently is selected from halogen, aryl, heteroaryl, aliphatic, heteroaliphatic, cyano, NO 2 , OH, or amino; \n n is from 1 to 5; and \n m is from 0 to 4; \n with the provisos that\n if -L 3 N(L 4 R 3 )L 3 - is \u2014CH 2 N(L 4 R 3 )C(O)\u2014, L 4 R 3  is n-propyl or isopropyl, ring A is phenyl, and n is 1 then R 2  is not 4-bromo or 4-benzo[d][1,3]dioxole; \n and where the compound is not \n ethyl 6-(2-((4-bromo-N-propylbenzamido)methyl)phenoxy)hexanoate; \n ethyl 6-(2-((4-(benzo[d][1,3]dioxol-5-yl)-N-propylbenzamido)methyl)phenoxy)hexanoate; \n 6-(2-((4-(benzo[d][1,3]dioxol-5-yl)-N-propylbenzamido)methyl)phenoxy)hexanoic acid; \n ethyl 6-(2-((4-(benzo[d][1,3]dioxol-5-yl)-N-isopropylbenzamido)methyl)phenoxy)hexanoate; \n 6-(2-((4-(benzo[d][1,3]dioxol-5-yl)-N-isopropylbenzamido)methyl)phenoxy)hexanoic acid.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 88.0
- Lexical Diversity: 1.51724
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14874008', '15482385', '15517893', '15766455', '11502456']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8269848043961829
- 35 USC 102 Novelty (BERT): 0.6458762166042078
- Combined Prediction Score: 0.8088739456169854
- Mean Citation Score: 478.44763200000006
- Max Citation Score: 714.689
- Similarity Product: 571.8016028811933

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test