PATENT CLAIM ANALYSIS

Application Number: 16108964
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["544", "106000"]

Abstract:
Embodiments of the disclosure relate to selectively substituted quinolone compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Claim (Index 8):
A method for treatment of systemic lupus erythematosus, cutaneous lupus, neuropsychiatric lupus, or lupus, comprising administering a pharmaceutically effective amount of two or more compounds or pharmaceutically acceptable salts according to Formula (I): wherein at least one of R 1  and R 2  is \u2014H, methyl, or ethyl, and the other is\n H, or the other is \n C 1 -C 6  alkyl that is optionally substituted with:\n \u2014OH, methoxy, ethoxy, \u2014OCH(CH 3 ) 2 , \u2014O(CH 2 ) 2 CH 3 , phenyl, furanyl, \u2014O(CH 2 ) 2 OH, phenoxy, methylthio, \u2014F, \u2014N(CH 3 ) 2 , cyano, pyridinyloxy, fluorophenoxy, isochromanyl, phenol, benzylamino, \u2014NHCH 3 , oxo-, amino, carboxyl, 7-member spiroaminyl, a three to six member cycloalkyl, saturated or unsaturated and optionally including one or more heteroatoms selected from O and N, and optionally substituted at one or more C or N atoms by methyl, cyano, fluoro, methylamino, or trifluoromethyl; or the other is \n \n C 3 -C 7  cycloalkane, saturated or unsaturated, optionally bridged, optionally including one or more heteroatoms selected from O, S, and N, and optionally substituted at one or more C or N atoms by methyl, ethyl, pyridinyl, azetidinyl, acetamidyl, carboxamidyl, cyano, fluoro, methylamino, or trifluoromethyl; or \n R 1  and R 2 , together with the nitrogen atom to which they are attached, form an 8 to 11 member spirodiamine, an 8 member bicyclodiamine, a 7 member spiroxamine, a piperidinyl optionally substituted with ethyl, or a four to six member cycloalkyl, optionally substituted with at least one of carboxamidyl, aminomethyl, methyl, (ethylamino)methyl, (dimethylamino)methyl, dimethylamino, (methylamino)methyl, and amino; and wherein\n R 3  is \u2014H or methyl.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 96.0
- Lexical Diversity: 1.10256
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14513556', '15670904', '14908164', '14806174', '13907202']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8718074521894746
- 35 USC 102 Novelty (BERT): 0.620913009526122
- Combined Prediction Score: 0.8467180079231393
- Mean Citation Score: 577.5672900000002
- Max Citation Score: 622.8006
- Similarity Product: 546.2239886415839

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test