PATENT CLAIM ANALYSIS

Application Number: 16304634
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-09
Patent Classification: ["540", "575000"]

Abstract:
Relating to processes for preparing suvorexant or its pharmaceutically acceptable salts through the formation of a cocrystal of (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate hydrochloride with (R)-(+)-1,1,2-triphenyl-1,2-ethanediol ((R)-TED). This cocrystal provides the resolution of an intermediate of suvorexant, in particular, of (rac)-benzyl5-methyl-1,4-diazepane-1-carboxy-lateor a hydrochloride salt thereof. It also relates to a new cocrystal useful in such preparation processes.

Claim (Index 14):
A process for preparing suvorexant of formula (I) or a pharmaceutically acceptable salt thereof, which comprises: a) carrying out the resolution process of  claim 5 , to yield (R)-benzyl 5-methyl-1,4-diazepane-1-carboxylate of formula (R)-(III) or a hydrochloride salt thereof, b) N-protecting a compound of formula (R)-(III) or its hydrochloride salt, optionally in the presence of a base, with an orthogonal protecting group PG, to yield a compound of formula (VIII) c) cleavage of the Cbz group to yield a compound of formula (IX); wherein PG is an amino protecting group;\n d) coupling the compound thus obtained with a benzoxazole derivative of formula (VII), wherein Y is H, Cl or Br, \n to yield a compound of formula (X) wherein PG is an amino protecting group; e) N-deprotecting the compound of formula (X) to yield a compound of formula (XI); f) coupling the compound of formula (XI) with a benzoic acid derivative of formula (IV) wherein X is OH or Cl, to yield suvorexant or a pharmaceutically acceptable salt thereof and; if desired,\n g) converting the resulting suvorexant free base into a salt thereof by reacting it with a pharmaceutically acceptable acid.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 98.0
- Lexical Diversity: 1.60417
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16073929', '15501295', '12061499', '13147337', '10536618']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6551370039233763
- 35 USC 102 Novelty (BERT): 0.5266201525293953
- Combined Prediction Score: 0.6422853187839782
- Mean Citation Score: 238.975446
- Max Citation Score: 276.726
- Similarity Product: 175.2308835471869

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test