PATENT CLAIM ANALYSIS

Application Number: 15762993
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["514", "236200"]

Abstract:
The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases.

Claim (Index 2):
A compound according to  claim 1  of Formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n Cy is a group of Formula (Cy-A) or (Cy-B): \n A 1  is NR 1 , O or S; R 1  is H or C 1-6  alkyl; R 2  is H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, (C 6-10  aryl)C 1-3  alkylenyl, (C 3-10  cycloalkyl)C 1-3  alkylenyl, (5-10 membered heteroaryl)C 1-3  alkylenyl, (4-10 membered heterocycloalkyl)C 1-3  alkylenyl, CN, SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550C)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550C)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 , wherein each of said C 1-6  alkyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl, (C 6-10  aryl)C 1-3  alkylenyl, (C 3-10  cycloalkyl)C 1-3  alkylenyl, (5-10 membered heteroaryl)C 1-3  alkylenyl or (4-10 membered heterocycloalkyl)C 1-3  alkylenyl forming R 2  is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, CN, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550O)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 ; A 3  is N or CR 3 ; R 3  is selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, CN, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550O)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 ; or R 2  and R 3 , together with the atoms to which R 2  and R 3  are attached, together form a fused benzo ring that is optionally substituted with 1, 2, 3 or 4 substituents independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, CN, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550O)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 ; A 4  is N or CR 4 ; R 4  is selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, CN, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550O)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 ; R 5  is selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, CN, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550O)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 ; B is absent (a bond), or is selected from NR 6 , O, S, S(O) and S(O) 2 ; R 6  is H or C 1-6  alkyl; D is C 1-4  alkylene optionally substituted by 1, 2, 3, 4 or 5 substituents selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, CN, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550O)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 ; E is NR 7  or O; R 7  is H or C 1-6  alkyl; R 8 , R 9 , R 10 , R 11  and R 12  are each independently selected from H, C 1-6  alkyl, Cy 1 , C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, CN, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550O)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 ; provided that no more than two of R 8 , R 9 , R 10 , R 11  and R 12  is Cy 1 ; each Cy 1  is independently selected from C 6-14  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, (C 6-14  aryl)C 1-3  alkylenyl, (C 3-10  cycloalkyl)C 1-3  alkylenyl, (5-10 membered heteroaryl)C 1-3  alkylenyl, (4-10 membered heterocycloalkyl)C 1-3  alkylenyl, wherein each of said C 6-14  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, (C 6-14  aryl)C 1-3  alkylenyl, (C 3-10  cycloalkyl)C 1-3  alkylenyl, (5-10 membered heteroaryl)C 1-3  alkylenyl and (4-10 membered heterocycloalkyl)C 1-3  alkylenyl forming Cy 1  is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from Cy 2 , C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, CN, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550O)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 ; each Cy 2  is independently selected from C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, (C 6-10  aryl)C 1-3  alkylenyl, (C 3-10  cycloalkyl)C 1-3  alkylenyl, (5-10 membered heteroaryl)C 1-3  alkylenyl, (4-10 membered heterocycloalkyl)C 1-3  alkylenyl, wherein each of said C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, (C 6-10  aryl)C 1-3  alkylenyl, (C 3-10  cycloalkyl)C 1-3  alkylenyl, (5-10 membered heteroaryl(C 1-3  alkylenyl and (4-10 membered heterocycloalkyl)C 1-3  alkylenyl forming Cy 2  is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, halogen, C 1-6  haloalkyl, CN, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 , OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)NR c1 R d1 , NR c1 C(\u2550O)OR a1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O)NR c1 R d1 , S(\u2550O) 2 R b1 , NR c1 S(\u2550O) 2 R b1  and S(\u2550O) 2 NR c1 R d1 ; R a1 , R b1 R c1  and R d1  are each independently selected from H, C 1-6  alkyl, C 2-6  alkenyl and C 2-6  alkynyl; and each R e1  is, independently, H, C 1-4  alkyl, CN or NO 2 .

Metadata:
- Claim Count in Document: 14.0
- Percentile: 90.0
- Lexical Diversity: 1.64516
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12692078', '14795499', '15613379', '14775917', '12813148']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7727041131028657
- 35 USC 102 Novelty (BERT): 0.5099607575965641
- Combined Prediction Score: 0.7464297775522355
- Mean Citation Score: 282.784528
- Max Citation Score: 299.21698
- Similarity Product: 247.1649533077025

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test