PATENT CLAIM ANALYSIS

Application Number: 15871802
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["424", "131100"]

Abstract:
Provided are anti-CD47 monoclonal antibodies (anti-CD47 mAbs) with distinct functional profiles as described herein, methods to generate anti-CD47 mAbs, and to methods of using these anti-CD47 mAbs as therapeutics for the prevention and treatment of solid and hematological cancers, ischemia-reperfusion injury, cardiovascular diseases, autoimmune diseases, inflammatory diseases or as diagnostics for determining the level of CD47 in tissue samples.

Claim (Index 102):
A monoclonal antibody, or an antigen binding fragment thereof, which:\n a. binds to human CD47; b. blocks SIRP (binding to human CD47; c. increases phagocytosis of human tumor cells; d. induces death of human tumor cells; e. exhibits pH-dependent binding to human CD47 present on a cell; and\n wherein the monoclonal antibody, or an antigen binding fragment thereof, further comprises one or more characteristics selected from the group consisting of: \n i) causes no detectable agglutination of human red blood cells, or causes reduced agglutination of human red blood cells, and \n ii) has reduced human red blood cell binding, or has minimal human red blood cell binding.

Metadata:
- Claim Count in Document: 119.0
- Percentile: 86.0
- Lexical Diversity: 1.47826
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15820054', '15711971', '15473206', '15712010', '14700105']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7893817222459583
- 35 USC 102 Novelty (BERT): 0.6518289736614851
- Combined Prediction Score: 0.775626447387511
- Mean Citation Score: 516.6316039999998
- Max Citation Score: 732.64636
- Similarity Product: 568.5779599609947

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test