PATENT CLAIM ANALYSIS

Application Number: 16266683
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["544", "385000"]

Abstract:
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the cyclocondensation and purification of N-protected 3,6-(aminoalkyl)-2,5-diketopiperazines from N-protected amino acids. Disclosed embodiments describe methods for the synthesis of 3,6-bis-[N-protected am inoalkyl]-2,5-diketopiperazine comprising heating a mixture of an amino acid in the presence of a catalyst in an organic solvent. The catalyst is selected from the group comprising sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl phosphonic acid and phosphorous pentoxide among others. The solvent is selected from the group comprising: dimethylacetamide, N-methyl-2-pyrrolidone, diglyme, ethyl glyme, proglyme, ethyldiglyme, m-cresol, p-cresol, o-cresol, xylenes, ethylene glycol and phenol among others.

Claim (Index 15):
The method of  claim 13 , wherein the concentration of phosphorous pentoxide is from 20% to 35% that of the N-protected amino acid.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 99.0
- Lexical Diversity: 1.80769
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15237427', '14543464', '13368172', '11208087', '12633673']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7991129936942999
- 35 USC 102 Novelty (BERT): 0.5766688803126181
- Combined Prediction Score: 0.7768685823561318
- Mean Citation Score: 414.528132
- Max Citation Score: 484.70428
- Similarity Product: 387.8827191746569

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test