PATENT CLAIM ANALYSIS

Application Number: 15780328
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "228200"]

Abstract:
The present disclosure provides for methods for preparing tricyclic PI3K inhibitor compounds in high yield and purity in aqueous solvent systems.

Claim (Index 22):
The process of  claim 21  wherein:\n (i) the solvent system comprises water and acetic acid or consists essentially of water and acetic acid wherein the volume ratio of acetic acid to water is from about 1:1 to about 10:1, from about 1:1 to about 5:1 or from about 1:1 to about 3:1, or about 3:1; \n (ii) the metal scavenger is silica-thiol; and \n (iii) the dissolution temperature is from about 80\u00b0 C. to about 100\u00b0 C., the seed crystals are combined with the filtrate at a temperature of from about 70\u00b0 C. to about 80\u00b0 C., and the crystallization temperature is from about 0\u00b0 C. to about 10\u00b0 C.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 93.0
- Lexical Diversity: 1.1
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14524204', '14972333', '13018068', '12586241', '14930929']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8145664384536674
- 35 USC 102 Novelty (BERT): 0.5229116344288511
- Combined Prediction Score: 0.7854009580511857
- Mean Citation Score: 302.856558
- Max Citation Score: 309.51782000000014
- Similarity Product: 186.24028775343425

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test