PATENT CLAIM ANALYSIS

Application Number: 16074017
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-03
Patent Classification: ["540", "474000"]

Abstract:
A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

Claim (Index 4):
The compound of formula I of  claim 1 , wherein\n L 1  and L 2  and the Effector Domain are as defined in  claim 1 but L 1  and L 2  not each independently direct bond, substituted or unsubstituted \u2014(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n O(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)\u2014, substituted or unsubstituted \u2014(CH 2 ) n C(O)(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)O(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n NH(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)NH(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n S(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(CH 2 ) n S(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n O(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)O(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n NH(C 1 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)NH(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n S(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(CH 2 ) n S(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n O(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)O(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n NH(C 1 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)NH(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n S(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(CH 2 ) n S(C 2 -C 6 )alkynyl-, wherein each alkyl, alkenyl, and alkynyl group may be optionally substituted with alkyl, alkoxy, amino, carboxyl, cyano, nitro, or trifluoromethyl; and the Effector Domain is a compound of Formula VIII wherein R 12 , R 14 , R 14\u2032 , R 16 , and R 27  are not each independently hydrogen or alkyl and R 13 , R 14 , R 14\u2032 , and R 16  are not each independently hydrogen, halogen, amino, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted perfluoroalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted aryl, substituted or unsubstituted alkylaryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkylaryl, (CH 2 ) n CN, (CH 2 ) n CF 3 , (CH 2 ) n C 2 F 5 , (CH 2 ) n OR 19 , (CH 2 ) n C(O)R 19 , (CH 2 ) n C(O)OR 19 , (CH 2 ) n OC(O)R 19 , (CH 2 ) n NR 20 R 21 , (CH 2 ) n C(O)NR 20 R 21 , (CH 2 ) n NR 22 C(O)R 19 , (CH 2 ) n NR 22 C(O)OR 19 , (CH 2 ) n NR 22 C(O)NR 20 R 21 , (CH 2 ) n S(O) j NR 20 R 21 , (CH 2 ) n NR 22 S(O) j R 19 , or \u2014(CH 2 ) n NR 22 S(O) j NR 20 R 21 ; n is an integer selected from 0, 1, 2, 3, 4, 5, and 6; j is an integer selected from 0, 1, and 2; R 19 , R 20 R 21 , and R 22  are each independently hydrogen, halogen, amino, cyano, nitro, trifluoromethyl, alkyl, alkenyl, alkynyl, cycloalkyl, perfluoroalkyl, alkoxy, alkylamino, alkylthio, aryl, alkylaryl, heteroalkyl, heterocycloalkyl, heteroaryl, or heteroalkylaryl, or R 19  and R 22  are as described above, and R 20  and R 21 , together with the N atom to which they are attached, form a substituted or unsubstituted 5-, 6-, or 7-membered heterocycloalkyl or a substituted or unsubstituted 5-membered heteroaryl, wherein each of the above groups listed for R 13 , R 15 , and R 17  may be optionally independently substituted with 1 to 3 groups selected from halogen, amino, cyano, nitro, trifluoromethyl, alkyl, alkenyl, alkynyl, cycloalkyl, perfluoroalkyl, alkoxy, alkylamino, alkylthio, aryl, alkylaryl, heteroalkyl, heterocycloalkyl, heteroaryl, heteroalkylaryl, (CH 2 ) n CN, (CH 2 ) n CF 3 , (CH 2 ) n C 2 F 5 , (CH 2 ) n OR 19 , (CH 2 ) n C(O)R 19 , (CH 2 ) n C(O)OR 19 , (CH 2 ) n OC(O)R 19 , (CH 2 ) n NR 20 R 21 , (CH 2 ) n C(O)NR 20 R 21 , (CH 2 ) n NR 22 C(O)R 19 , (CH 2 ) n NR 22 C(O)OR 19 , (CH 2 ) n NR 22 C(O)NR 20 R 21 , (CH 2 ) n SR 19 , (CH 2 ) n S(O) j NR 20 R 21 , (CH 2 ) n NR 22 S(O) j R 19 , or \u2014(CH 2 ) n NR 22 S(O) j NR 20 R 21 .

Metadata:
- Claim Count in Document: 26.0
- Percentile: 95.0
- Lexical Diversity: 1.35
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15728282', '13990396', '14987653', '14793296', '15581749']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6490433852480144
- 35 USC 102 Novelty (BERT): 0.5058886845729126
- Combined Prediction Score: 0.6347279151805043
- Mean Citation Score: 213.20821
- Max Citation Score: 239.5702
- Similarity Product: 180.05482862503533

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test