PATENT CLAIM ANALYSIS

Application Number: 15974921
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["530", "317000"]

Abstract:
The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.

Claim (Index 1):
A compound having the structure:\n A-L-B, wherein A comprises a cyclophilin binding moiety having the structure of Formula IV: wherein Z 3  and Z 4  are each, independently, hydroxyl, optionally substituted C 1 -C 6  alkyl, optionally substituted C 1 -C 6  heteroalkyl, or Z 3  and Z 4  combine to form, with the atoms to which they are attached, an optionally substituted 10 to 40 member macrocycle; at least one of Z 3 , Z 4 , or R 5  comprises a point of attachment to the cross-linking group; R 5  is optionally substituted C 1 -C 6  alkyl, optionally substituted C 2 -C 6  alkenyl, optionally substituted C 2 -C 6  alkynyl, optionally substituted C 1 -C 6  heteroalkyl, optionally substituted C 2 -C 6  heteroalkenyl, optionally substituted C 2 -C 6  heteroalkynyl, optionally substituted C 3 -C 10  carbocyclyl, optionally substituted C 6 -C 10  aryl, optionally substituted C 6 -C 10  aryl C 1 -C 6  alkyl, optionally substituted C 2 -C 9  heterocyclyl, or optionally substituted C 2 -C 9  heterocyclyl C 1 -C 6  alkyl; R 6  is optionally substituted C 1 -C 6  alkyl; L is a linker having the structure:\n A 1 -(B 1 ) f \u2014(C 1 ) g \u2014(B 2 ) h -(D)-(B 3 ) i \u2014(C 2 ) j \u2014(B 4 ) k -A 2  \n wherein A 1  is a bond between the linker and the cyclophilin binding moiety; A 2  is a bond between the cross-linking group and the linker; B 1 , B 2 , B 3 , and B 4  each, independently, is selected from optionally substituted C 1 -C 2  alkyl, optionally substituted C 1 -C 3  heteroalkyl, O, S, and NR N ; R N  is hydrogen, optionally substituted C 1-4  alkyl, optionally substituted C 2-4  alkenyl, optionally substituted C 2-4  alkynyl, optionally substituted C 2-6  heterocyclyl, optionally substituted C 6-12  aryl, or optionally substituted C 1-7  heteroalkyl; C 1  and C 2  are each, independently, selected from carbonyl, thiocarbonyl, sulphonyl, or phosphoryl; f, g, h, I, j, and k are each, independently, 0 or 1; and D is optionally substituted C 1-10  alkyl, optionally substituted C 2-10  alkenyl, optionally substituted C 2-10  alkynyl, optionally substituted C 2-6  heterocyclyl, optionally substituted C 6-12  aryl, optionally substituted C 2 -C 10  polyethylene glycol, or optionally substituted C 1-10  heteroalkyl, or a chemical bond linking A-(B 1 ) f \u2014(C 1 ) g \u2014(B 2 ) h \u2014 to \u2014(B 3 ) i \u2014(C 2 ) j \u2014(B 4 ) k -A 2 ; and B comprises a cross-linking group, wherein the cross-linking group is a mixed disulfide, maleimide, vinyl sulfone, vinyl ketone, alkyl halide, isocyanate, isothiocyanate, sulfonyl chloride, acid halide, active ester, acid anhydride, acylazide, imidoester, haloheteroaryl, diazo compound, carbodiimide, hydrazide, alkoxyamine, azide, or alkyne.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.75
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15282430', '15974923', '14991403', '15542350', '15077865']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7172908937534251
- 35 USC 102 Novelty (BERT): 0.6241521931521384
- Combined Prediction Score: 0.7079770236932965
- Mean Citation Score: 384.452484
- Max Citation Score: 582.809
- Similarity Product: 536.8201363376974

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test