PATENT CLAIM ANALYSIS

Application Number: 15864378
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["530", "412000"]

Abstract:
The present invention is directed to methods for purifying a protein of interest, e.g., an antibody, from a sample comprising the protein of interest and at least one impurity, e.g., an aggregate, by employing a hydrophobic interaction chromatography (HIC) method that allows for binding of both the protein of interest and the at least one impurity under strong binding conditions. The present invention is based, at least in part, on the finding that both flow through and bind-elute techniques can be combined to achieve greater purification and recovery of a protein of interest, e.g., an antibody, under isocratic wash conditions and strong binding conditions.

Claim (Index 22):
The method of  claim 1 ,\n (a) wherein a precursor sample comprising the protein of interest has been subjected to mixed mode chromatography to generate the sample; and/or (b) further comprising subjecting the preparation comprising a protein of interest and having a reduced level of one impurity to mixed mode chromatography; optionally wherein the mixed mode chromatography is performed using CaptoAdhere resin.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 86.0
- Lexical Diversity: 1.91935
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14077574', '13831181', '14584492', '15545271', '14584619']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6739005763248596
- 35 USC 102 Novelty (BERT): 0.6269975720870191
- Combined Prediction Score: 0.6692102759010755
- Mean Citation Score: 392.83938
- Max Citation Score: 616.52576
- Similarity Product: 433.5891903388214

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test