PATENT CLAIM ANALYSIS

Application Number: 15764613
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "046000"]

Abstract:
Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment of an infectious disease (e.g., bacterial infection (e.g., tuberculosis, methicillin-resistant  Staphylococcus aureus ).

Claim (Index 1):
A compound of Formula (I): or a pharmaceutically acceptable salt, tautomer solvate, hydrate, polymorph, co-crystal, tautomer, stereoisomer, prodrug, or isotopically labeled derivative thereof, wherein:\n G 2  is \u2014S(\u2550O) 2 \u2014, \u2014P(\u2550O)(R e )\u2014, \u2014P(\u2550O)(OR e )\u2014, \u2014P(\u2550O)(N(R e ) 2 )\u2014, \u2014P(\u2550S)(R e )\u2014, \u2014P(\u2550S)(OR e )\u2014, \u2014P(\u2550S)(N(R e ) 2 )\u2014, \u2014Si(OR e ) 2 \u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, \u2014C(\u2550NR f )\u2014, \u2014(CH 2 ) h \u2014, \n \u2003or optionally substituted monocyclic 5- or 6-membered heteroarylene, wherein 1, 2, 3, or 4 atoms in the heteroarylene ring system are independently oxygen, nitrogen, or sulfur; A-B is \u2014(R A ) 2 C\u2014C(R B ) 2 \u2014 or \u2014R A C\u2550CR B \u2014, wherein each occurrence of R A  is independently hydrogen, halogen, optionally substituted alkyl, optionally substituted acyl, \u2014OR S1 , or \u2014N(R e ) 2 , and each occurrence of R B  is independently hydrogen, halogen, optionally substituted alkyl, optionally substituted acyl, \u2014OR S2 , or \u2014N(R e ) 2 ; X 5  is \u2014O\u2014, \u2014S\u2014, \u2014C(R d ) 2 \u2014, or \u2014NR f \u2014; Y is of formula: G 1  is \u2014C(R G1 )(R G2 )\u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, \u2014C(\u2550NR f )\u2014, \u2014C(\u2550C(R G1 )(R G2 ))\u2014, or \u2014C(OR G1 )(OR G2 )\u2014; each of R G1  and R G2  is independently hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, \u2014OR e , or \u2014N(R e ) 2 , or R G1  and R G2  are joined to form an optionally substituted carbocyclic ring or optionally substituted heterocyclic ring; Ring A is an optionally substituted carbocyclic, optionally substituted heterocyclic, optionally substituted aryl, or optionally substituted heteroaryl ring; L 1  is a bond or of formula: \u2003wherein L is oriented such that the position labeled a is attached a carbon atom and the position labeled b is attached to G 2 ; X 1  is a bond, \u2014O\u2014, \u2014C(R d ) 2 \u2014, \u2014(CH 2 ) q \u2014, or \u2014NR f \u2014; X 2  is a bond, \u2014O\u2014, \u2014C(R d ) 2 \u2014, \u2014(CH 2 ) t \u2014, or \u2014NR f \u2014; R 1  is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted boronyl, \u2014NO 2 , \u2014CN, \u2014OR e , \u2014N(R e ) 2 , \u2014C(\u2550NR e )R e , \u2014C(\u2550NR e )OR e , \u2014C(\u2550NR e )N(R e ) 2 , \u2014C(\u2550O)R e , \u2014C(\u2550O)OR e , \u2014C(\u2550O)N(R e ) 2 , \u2014NR e C(\u2550O)R e , \u2014NR e C(\u2550O)OR e , \u2014NR e C(\u2550O)N(R e ) 2 , \u2014OC(\u2550O)R e , \u2014OC(\u2550O)OR e , or \u2014OC(\u2550O)N(R e ) 2 ; each of R 2 , R 3 , and R 4  are independently hydrogen, halogen, optionally substituted C 1-6  alkyl, optionally substituted acyl, \u2014NO 2 , \u2014CN, \u2014OR e , or \u2014N(R e ) 2 ; R 5  is hydrogen, halogen, optionally substituted C 1-6  alkyl, \u2014NO 2 , \u2014CN, \u2014OR e , or \u2014N(R e ) 2 ; each of R 6a  and R 6b  is independently hydrogen, halogen, or optionally substituted C 1-6  alkyl; each of R 7a  and R 7b  is independently hydrogen, halogen, or optionally substituted C 1-6  alkyl; each of R 8a  and R 8b  is independently hydrogen, halogen, or optionally substituted C 1-6  alkyl; each of R 9a  and R 9b  is independently hydrogen, halogen, optionally substituted C 1-6  alkyl, \u2014OR e , or \u2014N(R e ) 2 ; each of R S1  and R S2  is independently hydrogen, optionally substituted C 1-6  alkyl, optionally substituted acyl, or an oxygen protecting group, or R S1  and R S2  are joined to form an optionally substituted heterocyclic ring; L S  is a bond, \u2014O\u2014, \u2014NR f \u2014, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted alkynylene, optionally substituted acylene, or optionally substituted arylene; each of V 1 , V 2 , V 3 , V 7 , V 8 , and V 9  is independently N, NR V , or CR V ; each occurrence of R V  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, \u2014NO 2 , \u2014CN, \u2014OR e , or \u2014N(R e ) 2 ; V N  is N, NR N , or CR N ; R N  is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, \u2014NO 2 , \u2014CN, \u2014OR e , or \u2014N(R Na ) 2 ; each occurrence of R Na  independently hydrogen, optionally substituted C 1-6  alkyl, optionally substituted acyl, or a nitrogen protecting group, or both R Na  are joined to form and optionally substituted heterocyclic or optionally substituted heteroaryl ring; each occurrence of R d  is independently hydrogen, halogen, optionally substituted C 1-6  alkyl, \u2014OR e , or \u2014N(R e ) 2 ; each occurrence of R e  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, an oxygen protecting group when attached to an oxygen atom, a nitrogen protecting group when attached to a nitrogen atom, or two R e  are joined to form and optionally substituted heterocyclic or optionally substituted heteroaryl ring; each R f  is independently hydrogen, optionally substituted C 1-6  alkyl, optionally substituted acyl, or a nitrogen protecting group; each of h, q, and t is independently 1, 2, or 3;  is a single, double, or triple bond, wherein R 6b  and R 7b  are absent when   is a double bond, and R 6a , R 6b , R 7a , and R 7b  are absent when   is a triple bond; and  indicates that each bond of the ring is a single or double bond. provided the compound is not of formula:

Metadata:
- Claim Count in Document: 54.0
- Percentile: 90.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15904143', '16334237', '15847856', '15104132', '15847430']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7483694616772687
- 35 USC 102 Novelty (BERT): 0.5143591991957892
- Combined Prediction Score: 0.7249684354291208
- Mean Citation Score: 265.80277
- Max Citation Score: 278.9836
- Similarity Product: 212.82890453538897

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test