PATENT CLAIM ANALYSIS

Application Number: 16129944
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "255050"]

Abstract:
Provided herein are 3-phenyl-7-hydroxy-isocoumarin compounds which are MIF inhibitors; compositions comprising said inhibitors and methods for treating or preventing diseases associated with MIF.

Claim (Index 52):
A method of treating cancer comprising administering to a patient in need thereof a pharmaceutical composition comprising a compound having the formula: wherein p is 4; z is 0 to 4;\n R 1  is C 1 -C 12  aliphatic; \n wherein R 1  can be unsubstituted or substituted with at least one of a halogen, a hydroxyl, an amino group, a sulfonyl group, a sulphonamide group, a thiol, a C 1 -C 6  alkyl, a C 1 -C 6  alkoxy, a C 1 -C 6  ether, a C 1 -C 6  thioether, a C 1 -C 6  ester, a C 1 -C 6  ketone, a C 1 -C 6  ketimine, a C 1 -C 6  sulfone, a C 1 -C 6  sulfoxide, a C 1 -C 6  primary amide, a C 1 -C 6  secondary amide, a halo C 1 -C 6  alkyl, a carboxyl group, a cyano group, a nitro group, a nitroso group, \u2014C(O)O\u2014C 1 -C 6  alkyl, \u2014OC(O)O\u2014C 1 -C 6  alkyl, \u2014OC(O)NR\u2032R\u2032, \u2014N(R\u2032)C(O)NR\u2032R\u2032, \u2014N(R\u2032)C(O)O\u2014C 1 -C 6  alkyl, or oxo; wherein R\u2032 is independently selected for each occurrence, from the group consisting of hydrogen and C 1 -C 6  alkyl;\n R 2  is independently selected from the group consisting of hydrogen, an amino group, a halogen, a cyano group, a nitro group, a nitroso group, and C 1 -C 12  aliphatic; \n R 3  is hydrogen; \n wherein independently any R 2  can be unsubstituted or substituted with at least one of a halogen, a hydroxyl, an amino group, a sulfonyl group, a sulphonamide group, a thiol, a C 1 -C 6  alkyl, a C 1 -C 6  alkoxy, a C 1 -C 6  ether, a C 1 -C 6  thioether, a C 1 -C 6  ester, a C 1 -C 6  ketone, a C 1 -C 6  ketimine, a C 1 -C 6  sulfone, a C 1 -C 6  sulfoxide, a C 1 -C 6  primary amide, a C 1 -C 6  secondary amide, a halo C 1 -C 6  alkyl, a carboxyl group, a cyano group, a nitro group, a nitroso group, \u2014C(O)O\u2014C 1 -C 6  alkyl, \u2014OC(O)O\u2014C 1 -C 6  alkyl, \u2014OC(O)NR\u2032R\u2032, \u2014N(R\u2032)C(O)NR\u2032R\u2032, \u2014N(R\u2032)C(O)O\u2014C 1 -C 6  alkyl, or oxo; wherein each R\u2032 is independently selected from the group consisting of hydrogen and C 1 -C 6  alkyl; or a pharmaceutically acceptable salt or a pharmaceutically acceptable hydrate thereof.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 97.0
- Lexical Diversity: 1.13636
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15129593', '11687611', '11415785', '11415552', '11344938']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7792907973378683
- 35 USC 102 Novelty (BERT): 0.6065011242114136
- Combined Prediction Score: 0.7620118300252229
- Mean Citation Score: 344.67509800000005
- Max Citation Score: 594.41205
- Similarity Product: 464.4961239667922

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test