PATENT CLAIM ANALYSIS

Application Number: 15880354
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "455000"]

Abstract:
Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest.

Claim (Index 1):
A method for expressing a protein in a cell of a subject, the method comprising:\n introducing into the subject (a) a donor sequence comprising a transgene encoding the protein and (b) one or more polynucleotides encoding one or more nucleases, each nuclease comprising (i) a DNA-binding domain and (ii) a cleavage domain or cleavage half-domain, wherein the DNA-binding domain has been engineered to bind to a first target site in intron 1 of a PPP1R12C gene in the genome of a cell; such that following cleavage of the PPP1R12C gene, the transgene is integrated into and expressed from the PPP1R12C gene.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 86.0
- Lexical Diversity: 1.2
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15014372', '13341228', '12150103', '14447378', '12798749']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6787373005762208
- 35 USC 102 Novelty (BERT): 0.6231972327718803
- Combined Prediction Score: 0.6731832937957868
- Mean Citation Score: 545.2530459999998
- Max Citation Score: 584.2724599999998
- Similarity Product: 531.5297423470639

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test