PATENT CLAIM ANALYSIS

Application Number: 15744712
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "016800"]

Abstract:
Provided are fusion polypeptides comprising fragments from a first and a second FGF family member, nucleic acids encoding the fusion polypeptides, vectors and host cells containing the same, and methods of making and using such compositions in the treatment of FGF-related diseases, disorders, and conditions.

Claim (Index 23):
A fusion polypeptide having a structure of formula (I):\n (S1)-(\u03b21)-(S2)-(\u03b22)-(S3)-(\u03b23)-(S4)-(\u03b24)-(S5)-(\u03b25)-(S6)-(\u03b26)-(S7)-(\u03b27)-(S8)-(\u03b28)-(S9)-(\u03b29)- (S10)-(\u03b210)-(S11)-(\u03b211)-(S12)-(\u03b212)-S13\u2003\u2003(I) wherein:\n a) \u03b22 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about I39 to G43 of FGF18 (SEQ ID NO:1) or from about V44 to G48 of FGF17-1 (SEQ ID NO:2); \n b) \u03b23 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about R45 to A48 of FGF18 (SEQ ID NO:1) or from about R50 to A53 of FGF17-1 (SEQ ID NO:2); \n c) \u03b25 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q69 to K75 of FGF18 (SEQ ID NO:1) or from about R74 to A80 of FGF17-1 (SEQ ID NO:2); \n d) \u03b26 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about F79 to L81 of FGF18 (SEQ ID NO:1) or from about K84 to I86 of FGF17-1 (SEQ ID NO:2); \n e) \u03b27 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about K88 to G91 of FGF18 (SEQ ID NO:1) or from about K93 to G96 of FGF17-1 (SEQ ID NO:2); \n f) \u03b28 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about V101 to K105 of FGF18 (SEQ ID NO:1) or from about V106 to I110 of FGF17-1 (SEQ ID NO:2); \n g) \u03b210 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about G121 to V124 of FGF18 (SEQ ID NO:1) or from about G126 to M129 of FGF17-1 (SEQ ID NO:2); \n h) \u03b211 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about K134 to T138 of FGF18 (SEQ ID NO:1) or from about Q139 to S143 of FGF17-1 (SEQ ID NO:2); \n each of 51, S2, S3, S4, S5, S6, S7, S8, S9, S10, S11, S12, and S13 is independently a spacer sequence having between 1 to about 50 amino acid residues; and wherein:\n i) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q24 to Y31 of FGF18 (SEQ ID NO:1); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about K63 to T68 of FGF17-1 (SEQ ID NO:2); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y116 to A122 of FGF17-1 (SEQ ID NO:2); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H151 to R155 of FGF17-1 (SEQ ID NO:2); or \n ii) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q29 to Y36 of FGF17-1 (SEQ ID NO: 2); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q58 to T63 of FGF18 (SEQ ID NO:1); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y116 to A122 of FGF17-1 (SEQ ID NO:2); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H151 to R155 of FGF17-1 (SEQ ID NO:2); or \n iii) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q29 to Y36 of FGF17-1 (SEQ ID NO: 2); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about K63 to T68 of FGF17-1 (SEQ ID NO:2); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y111 to A117 of FGF18 (SEQ ID NO:1); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H151 to R155 of FGF17-1 (SEQ ID NO:2); or \n iv) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q29 to Y36 of FGF17-1 (SEQ ID NO: 2); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about K63 to T68 of FGF17-1 (SEQ ID NO:2); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y116 to A122 of FGF17-1 (SEQ ID NO:2); \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H146 to R150 of FGF18 (SEQ ID NO:1); or \n v) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q24 to Y31 of FGF18 (SEQ ID NO:1); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q58 to T63 of FGF18 (SEQ ID NO:1); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y116 to A122 of FGF17-1 (SEQ ID NO:2); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H151 to R155 of FGF17-1 (SEQ ID NO:2); or \n vi) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q24 to Y31 of FGF18 (SEQ ID NO:1); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about K63 to T68 of FGF17-1 (SEQ ID NO:2); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y111 to A117 of FGF18 (SEQ ID NO:1); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H151 to R155 of FGF17-1 (SEQ ID NO:2); or \n vii) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q24 to Y31 of FGF18 (SEQ ID NO:1); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about K63 to T68 of FGF17-1 (SEQ ID NO:2); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y116 to A122 of FGF17-1 (SEQ ID NO:2); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H146 to R150 of FGF18 (SEQ ID NO:1); or \n viii) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q29 to Y36 of FGF17-1 (SEQ ID NO: 2); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about K63 to T68 of FGF17-1 (SEQ ID NO:2); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y111 to A117 of FGF18 (SEQ ID NO:1); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H146 to R150 of FGF18 (SEQ ID NO:1); or \n ix) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q29 to Y36 of FGF17-1 (SEQ ID NO: 2); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q58 to T63 of FGF18 (SEQ ID NO:1); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y116 to A122 of FGF17-1 (SEQ ID NO:2); \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H146 to R150 of FGF18 (SEQ ID NO:1); or \n x) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q29 to Y36 of FGF17-1 (SEQ ID NO: 2); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q58 to T63 of FGF18 (SEQ ID NO:1); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y111 to A117 of FGF18 (SEQ ID NO:1); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H151 to R155 of FGF17-1 (SEQ ID NO:2); or \n xi) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q24 to Y31 of FGF18 (SEQ ID NO:1); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about K63 to T68 of FGF17-1 (SEQ ID NO:2); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y111 to A117 of FGF18 (SEQ ID NO:1); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H146 to R150 of FGF18 (SEQ ID NO:1); or \n xii) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q24 to Y31 of FGF18 (SEQ ID NO:1); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q58 to T63 of FGF18 (SEQ ID NO:1); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y116 to A122 of FGF17-1 (SEQ ID NO:2); \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H146 to R150 of FGF18 (SEQ ID NO:1); or \n xiii) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q24 to Y31 of FGF18 (SEQ ID NO:1); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q58 to T63 of FGF18 (SEQ ID NO:1); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y111 to A117 of FGF18 (SEQ ID NO:1); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H151 to R155 of FGF17-1 (SEQ ID NO:2); or \n xiv) \u03b21 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q29 to Y36 of FGF17-1 (SEQ ID NO: 2); and \u03b24 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Q58 to T63 of FGF18 (SEQ ID NO:1); and \u03b29 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about Y111 to A117 of FGF18 (SEQ ID NO:1); and \u03b212 comprises an amino acid sequence exhibiting at least 90% homology to a fragment having residues from about H146 to R150 of FGF18 (SEQ ID NO:1).

Metadata:
- Claim Count in Document: 112.0
- Percentile: 86.0
- Lexical Diversity: 1.37838
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15107101', '14380277', '13515429', '15660116', '10251947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.775998347030893
- 35 USC 102 Novelty (BERT): 0.5472093257831431
- Combined Prediction Score: 0.753119444906118
- Mean Citation Score: 314.01251
- Max Citation Score: 411.7714
- Similarity Product: 282.26523108377467

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test