PATENT CLAIM ANALYSIS

Application Number: 15757027
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-10
Patent Classification: ["546", "197000"]

Abstract:
The present invention provides an improved process for the preparation of N-protected ((3S,4R)-4-(4-fluorophenyl)piperidin-3-yl)methanol (compound (A)) and further its transformation to Paroxetine and its pharmaceutically acceptable salts. The process comprises reaction of compound (II) with amido-malonate compound (C) in the presence of a chiral catalyst and optionally a dehydrating agent to obtain compound (B); followed by reduction of (B) in the presence of a reducing agent to provide compound (A).

Claim (Index 2):
The process according to the claim I, wherein the chiral catalyst is selected from the group consisting of (S)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine, (S)-2-(bis(3,5-bis(trifluoromethyl) phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine, (S)-2-(((tert-butyldimethyl)silyl)oxy) diphenylmethyl)pyrrolidine (diphenylprolinol-TBDMS), (S)-diphenyl(pyrroidin-2-yl)ethanol, (S)-pyrrolidine-2-carboxylicacid, (S)-2-(((triethylsilyl)oxy) diphenylmethyl)pyrrolidine (diphenylprolinol-TES) and (S)-2-(((tri isopropylsilyl)oxy) diphenylmethyl)pyrrolidine (diphenylprolinol-TIPS).

Metadata:
- Claim Count in Document: 17.0
- Percentile: 90.0
- Lexical Diversity: 1.81132
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14891028', '10488842', '11892785', '15322581', '13119743']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8026310010523848
- 35 USC 102 Novelty (BERT): 0.4841357398122022
- Combined Prediction Score: 0.7707814749283666
- Mean Citation Score: 212.217208
- Max Citation Score: 231.76048
- Similarity Product: 180.8281060515881

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test