PATENT CLAIM ANALYSIS

Application Number: 16053716
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "480000"]

Abstract:
Provided herein are methods for treating a subject with PNH comprising administering to a subject a therapeutically effective amount of complement component C5 (C5) inhibitor, complement component C3 (C3) inhibitor, or complement factor B (CFB) inhibitor in combination with a therapeutically effective amount of small molecule complement factor D (CFD) inhibitor of Formula I or Formula II, or a pharmaceutically acceptable salt thereof.

Claim (Index 33):
A method for treating paroxysmal nocturnal hemoglobinuria (PNH) in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a complement factor D (CFD) inhibitor selected from a compound of Formula I or Formula or a pharmaceutically acceptable salt thereof; wherein: X is selected from N and CH; R 1  is selected from hydrogen, C 1 -C 3  alkyl, and halogen; R 2  is selected from hydrogen and C 1 -C 3  alkyl; R 3  is selected from hydrogen, C 1 -C 3  alkyl, and halogen; R 4  is selected from hydrogen, C 1 -C 3  alkyl, and halogen; R 5  is selected from hydrogen, C 1 -C 3  alkyl, halogen, and cyano; wherein the subject at the time of administration of the CFD inhibitor has been receiving or is currently receiving a therapeutic regimen comprising the administration of a complement 5 (C5) inhibitor; and wherein the subject has a hemoglobin level of less than about 10 g/dL.

Metadata:
- Claim Count in Document: 98.0
- Percentile: 96.0
- Lexical Diversity: 1.74419
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13505150', '15260888', '15905158', '15642096', '15148839']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6954172305336244
- 35 USC 102 Novelty (BERT): 0.53061421865597
- Combined Prediction Score: 0.678936929345859
- Mean Citation Score: 283.294746
- Max Citation Score: 373.1991
- Similarity Product: 267.01232116118075

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test