PATENT CLAIM ANALYSIS

Application Number: 16060714
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "274000"]

Abstract:
The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in the prophylaxis or treatment of pain include compounds of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof: (I).

Claim (Index 26):
The method according to claim  1 , wherein the modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 is a compound of formula (I): wherein:\n W is group (Wa), group (Wb), group (Wc) or group (Wd): \n wherein:\n R 1  is H, C 1-4  alkyl, halo, haloC 1-4  alkyl, CN, C 1-4  alkoxy, or haloC 1-4  alkoxy; \n R 2  is H, C 1-4  alkyl, C 3-5  spiro carbocyclyl, haloC 1-4  alkyl or halo; \n R 3  is H, C 1-4  alkyl, haloC 1-4  alkyl, halo; or R 3  is absent; \n R 13  is H, C 1-4  alkyl, haloC 1-4  alkyl, halo; or R 13  is absent; \n R 14  is H, C 1-4  alkyl, haloC 1-4  alkyl, halo; or R 14  is absent; \n A is a 5 or 6 membered saturated or unsaturated heterocycle, with at least one O atom; which heterocycle is optionally fused with a cyclopropyl group, or a cyclobutyl group, or a cyclopentyl group to form a tricycle when considered together with the phenyl; \n wherein R 2  and R 3  may be attached to the same or a different ring atom; R 2  may be attached to a fused ring atom; and wherein R 13  and R 14  may be attached to the same or a different ring atom; \n wherein:\n R 16  is halo, C 1-4  alkyl, C 1-4  alkoxy, halo-C 1-4  alkyl, halo-C 1-4  alkoxy, or CN; \n R 17  is H, halo, cyano, C 1-4  alkyl or C 1-4  alkoxy; with the proviso that when R 17  is H, R 16  is not in the para position; \n wherein:\n R 22  is H, Cl, F, C 1-4  alkyl; \n R 23  is H, C 1-4  alkyl, Cl, CF 3 , O\u2014C 1-4  alkyl, OCF 3  or N(CH 3 ) 2 ; \n R 24  is H, Cl, F, C 1-4  alkyl, O\u2014C 1-4  alkyl, CN, OCF 3  or CF 3 ; \n R 25  is H, Cl, F, O\u2014C 1-4  alkyl or C 1-4  alkyl; and \n R 26  is H or C 1-4  alkyl;\n wherein for R 22  to R 26 , C 1-4  alkyl may be substituted by O-methyl; \n with the provisos that:\n not all of R 22  to R 26  may be H; \n when R 4  is H, then R 23  is methyl or CF 3  and R 22 , R 24 , R 25  and R 26  are all H; \n when one of R 22 , R 24 , R 25  or R 26  is F, then at least one of R 22  to R 26  cannot be H or F; and \n when R 24  is not H, at least one of R 22  or R 23  is not H; \n \n \n X is CH or N; \n Y is CR 15  or N;\n R 15  is H or C 1-4  alkyl; \n \n when W is group (Wa), group (Wb) or group (Wc), Z is group (Za): \n wherein:\n R 4  is C 1-4  alkyl; \n R 5  is H or C 1-4  alkyl; \n or R 4  and R 5  can be fused to form C 3-4  spiro carbocyclyl; \n when W is group (Wa), group (Wb) or group (Wd), Z is group (Zb): \n wherein:\n R 4  is H or C 1-4  alkyl; \n or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof.

Metadata:
- Claim Count in Document: 54.0
- Percentile: 94.0
- Lexical Diversity: 1.6
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14403011', '15730559', '14361510', '15208329', '14403048']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8153059529988959
- 35 USC 102 Novelty (BERT): 0.6306749902129918
- Combined Prediction Score: 0.7968428567203054
- Mean Citation Score: 527.578932
- Max Citation Score: 633.7182
- Similarity Product: 512.5439409236668

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test