PATENT CLAIM ANALYSIS

Application Number: 15754562
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["530", "300000"]

Abstract:
A connector of a helical coiled coil-type structure connecting a first and a second molecule, wherein the first molecule comprises a peptidic first alpha-helix and the second molecule comprises a peptidic second alpha-helix, which second alpha-helix is coiled to the first alpha-helix. The first alpha-helix comprises a C-terminal region consisting of a repeat of an amino acid motif a-x 1  and the C-terminal motif a-x 1 -x 2 , or an N-terminal region consisting of a repeat of an amino acid motif x 1 -a and the N-terminal motif x 2 -x 1 -a, where a is a motif sequence of 4-8 amino acids, x 1  is Lysin, and x 2  is an extension of the motif. The extension consists of 1-10 amino acids and does not comprise more than 4 consecutive amino acids incorporated in said motif a-x 1  or x 1 -a. In a multimeric protein, two polypeptide chains can be connected to each other by such connector.

Claim (Index 1):
A connector of a helical coiled coil-type structure which comprises a peptidic first alpha-helix and a peptidic second alpha-helix coiled to the first alpha-helix,\n wherein the first alpha-helix comprises:\n i) a C-terminal region consisting of a repeat of an amino acid motif a-x 1  and the C-terminal motif a-x 1 -x 2 ; or \n ii) an N-terminal region consisting of a repeat of an amino acid motif x 1 -a and the N-terminal motif x 2 -x 1 -a; \n wherein: a is a motif sequence of 4-8 amino acids; x 1  is Lysine; and x 2  is an extension of the motif, wherein the extension consists of 1-10 amino acids, and wherein the extension does not comprise more than 4 consecutive amino acids incorporated in said motif a-x 1  or x 1 -a, and wherein: a) the motif a-x 1  is SEQ ID NO:1 and the motif a-x 1 -x 2  is any of SEQ ID NO:41, SEQ ID NO:69, or SEQ ID NO:71, which motif a-x1-x2 is optionally extended by one or more amino acids; or b) the motif a-x 1  is SEQ ID NO:3 and the motif a-x 1 -x 2  is any of SEQ ID NO:43, SEQ ID NO:85, or SEQ ID NO:87, which motif a-x1-x 2  is optionally extended by one or more amino acids; or c) the motif a-x 1  is SEQ ID NO:5 and the motif a-x 1 -x 2  is any of SEQ ID NO:45, SEQ ID NO:101, or SEQ ID NO:103, which motif a-x 1 -x 2  is optionally extended by one or more amino acids; or d) the motif a-x 1  is SEQ ID NO:7 and the motif a-x1-x 2  is any of SEQ ID NO:47, SEQ ID NO:117, or SEQ ID NO:119, which motif a-x1-x 2  is optionally extended by one or more amino acids; or e) the motif x 1 -a is SEQ ID NO:2 and the motif x 2 -x 1 -a is any of SEQ ID NO:42, SEQ ID NO:77, or SEQ ID NO:79, which motif x 2 -x 1 -a is optionally extended by one or more amino acids; or f) the motif x1-a is SEQ ID NO:4 and the motif x 2 -x 1 -a is any of SEQ ID NO:44, SEQ ID NO:93, or SEQ ID NO:95, which motif x 2 -x 1 -a is optionally extended by one or more amino acids; or g) the motif x 1 -a is SEQ ID NO:6 and the motif x 2 -x 1 -a is any of SEQ ID NO:46, SEQ ID NO:109, or SEQ ID NO:111, which motif x 2 -x 1 -a is optionally extended by one or more amino acids; or h) the motif x 1 -a is SEQ ID NO:8 and the motif x 2 -x 1 -a is any of SEQ ID NO:48, SEQ ID NO:125, or SEQ ID NO:127, which motif x 2 -x 1 -a is optionally extended by one or more amino acids.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 88.0
- Lexical Diversity: 2.39437
- Patent Class: 530.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14892973', '14414337', '11628483', '16080738', '14735024']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6914328576936558
- 35 USC 102 Novelty (BERT): 0.5351935090692118
- Combined Prediction Score: 0.6758089228312114
- Mean Citation Score: 310.62773
- Max Citation Score: 384.76822
- Similarity Product: 292.9775155085158

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test