PATENT CLAIM ANALYSIS

Application Number: 15773466
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-01
Patent Classification: ["514", "04400A"]

Abstract:
A pharmaceutical composition can be provide for treating or preventing heart failure. Additionally, siRNA and a vector expressing said siRNA can be provided that can be used in the pharmaceutical composition for treating or preventing heart failure. For example, a pharmaceutical composition can be provided for treating or preventing heart failure that contains a DNA sequence encoding RNA containing a sense strand sequence of consecutive 18 to 29 nucleotides from angiopoietin-like protein 2 (ANGPTL2) mRNA or the alternative splicing type RNA thereof and an antisense strand sequence complementary to the sense strand sequence under control of a promoter, and a pharmaceutically acceptable carrier.

Claim (Index 42):
A method for determining whether a subject is in need of treatment or prevention of heart failure with the pharmaceutical composition according to  claim 28  by measuring expression of angiopoietin-like protein 2 (ANGPTL2) in blood derived from a dilated cardiomyopathy (DCM) patient,\n wherein blood in the aortic root (Ao) and blood in the coronary sinus (CS) of a dilated cardiomyopathy patient are separately evaluated for expression levels of angiopoietin-like protein 2 (ANGPTL2), \n wherein when the expression level of angiopoietin-like protein 2 (ANGPTL2) in the blood of the coronary sinus (CS) is higher than the expression level in the blood of the aortic root (Ao), it is determined that the subject from which the blood is derived is in need of treatment or prevention of heart failure.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 97.0
- Lexical Diversity: 1.7619
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14342867', '12811306', '13702033', '12096216', '13389236']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7984200273623674
- 35 USC 102 Novelty (BERT): 0.5294727304985622
- Combined Prediction Score: 0.7715252976759869
- Mean Citation Score: 307.718864
- Max Citation Score: 339.27847
- Similarity Product: 210.56587982418893

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test