PATENT CLAIM ANALYSIS

Application Number: 15888757
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "136100"]

Abstract:
The invention is among others concerned with human CD3 binding antibodies comprising a heavy chain and light chain wherein said heavy chain comprises a variable region that comprises the amino acid sequence: QVQLV QSGGG VVQPG RSLRL SCVAS CFTFS SYGMH WVRQA PGKGL EWVAA IWYX 1 X 2  RKQDY ADSVK GRFTI SRDNS KNTLY LQMNS LRAED TAVYY CTRGT GYNWF DPWGQ GTLVT VSS with 0-5 amino acid insertions, deletions, substitutions, additions or a combination thereof at one or more positions other than the position indicated by X 1 X 2 ; wherein X 1 =N and X 2 =A; X 1 =N and X 2 =T; X 1 =S and X 2 =G; X 1 =H and X 2 =G; X 1 =D and X 2 =G; or X 1 =H and X 2 =A. The invention is also concerned with bispecific antibodies that have a heavy chain as defined herein above. The invention is also concerned with methods of production of the antibody, cells producing the antibody and with (medical) uses of the antibody.

Claim (Index 32):
The bispecific antibody of  claim 31 , wherein said mutant CH2 and/or lower hinge domain comprises an amino acid substitution at positions 235 and/or 236.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 88.0
- Lexical Diversity: 1.87879
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15205629', '14040023', '15747385', '15879260', '13473017']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.796673512491796
- 35 USC 102 Novelty (BERT): 0.6647094941034064
- Combined Prediction Score: 0.783477110652957
- Mean Citation Score: 493.6911400000001
- Max Citation Score: 790.5217
- Similarity Product: 596.1915675462367

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test