PATENT CLAIM ANALYSIS

Application Number: 15863076
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "204100"]

Abstract:
Provided herein are methods and related compositions for administering viral vectors and synthetic nanocarriers comprising an immunosuppressant. In some embodiments, the methods and compositions provided herein achieve improved transgene expression and/or immune response reduction, such as downregulated IgM and/or IgG immune responses.

Claim (Index 27):
A method comprising:\n to a first subject, (1) coadministering (a) a dose of immunosuppressant comprised in synthetic nanocarriers and (b) a dose of a viral vector, and (2) administering, without a dose of the viral vector, (c) a pre-dose and/or a post-dose of the immunosuppressant comprised in synthetic nanocarriers, wherein the amount of the immunosuppressant of (a) and (c) together is equal to an amount of immunosuppressant of (d) a dose of the immunosuppressant comprised in synthetic nanocarriers that when coadministered with the viral vector, without a pre-dose or a post-dose of the immunosuppressant coupled to synthetic nanocarriers, reduces an immune response against the viral vector or increases transgene expression of the viral vector in a second subject.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.24324
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14846964', '14846967', '14269047', '14802260', '14269056']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7322126436360747
- 35 USC 102 Novelty (BERT): 0.5967565600904768
- Combined Prediction Score: 0.718667035281515
- Mean Citation Score: 368.570116
- Max Citation Score: 442.11313
- Similarity Product: 338.6311077276028

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test