PATENT CLAIM ANALYSIS

Application Number: 15904269
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["424", "093200"]

Abstract:
CRISPR/CAS-related compositions and methods for treatment of Leber's Congenital Amaurosis 10 (LCA10) are disclosed.

Claim (Index 1):
A method of treating LCA10 in a subject in need thereof comprising administering to said subject:\n (i) a viral vector comprising a nucleotide sequence encoding a first gRNA molecule comprising a first targeting domain complementary with a first target domain from the CEP290 gene, wherein said first targeting domain comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:530 (CEP290-323), SEQ ID NO:555 (CEP290-485), SEQ ID NO:468 (CEP290-490), and SEQ ID NO:538 (CEP290-492); and (ii) a viral vector comprising a nucleotide sequence encoding a Cas9 molecule; wherein said viral vector comprising a nucleotide sequence encoding a first gRNA molecule and said viral vector comprising a nucleotide sequence encoding a Cas9 molecule are capable of delivery to a non-dividing cell, and wherein said administration results in NHEJ-mediated alteration of the LCA10 target position in one or more cells of said subject.

Metadata:
- Claim Count in Document: 77.0
- Percentile: 88.0
- Lexical Diversity: 1.0
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14644181', '15825616', '14536319', '15832567', '15127087']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7488040085060356
- 35 USC 102 Novelty (BERT): 0.7339979061199506
- Combined Prediction Score: 0.7473233982674271
- Mean Citation Score: 565.7883320000002
- Max Citation Score: 909.1263
- Similarity Product: 750.2994229672553

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test