PATENT CLAIM ANALYSIS

Application Number: 16040734
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-07
Patent Classification: ["436", "092000"]

Abstract:
The present invention provides a novel method that is capable of detecting a trifluridine-related substance from a sample containing trifluridine or a salt thereof by high-performance liquid chromatography comprising two steps that are performed under gradient conditions. More specifically, the method is for detecting a trifluridine-related substance, the method comprising the step of subjecting a sample containing trifluridine or a salt thereof to high-performance liquid chromatography using a mobile phase composed of an organic phase and an aqueous phase, wherein the step of high-performance liquid chromatography comprises steps 1 and 2 that satisfy the following requirements: Step 1: the percentage of the organic phase in the entire mobile phase is 1 to 14% by volume; and Step 2: after step 1, elution is performed by applying a gradient of increasing the percentage of the organic phase in the entire mobile phase.

Claim (Index 1):
A method for detection, comprising:\n subjecting a sample including trifluridine or a salt thereof to high-performance liquid chromatography with a mobile phase comprising an organic phase and an aqueous phase; and detecting at least one of related substances 1 to 6 in the sample by the high-performance liquid chromatography, wherein the high-performance liquid chromatography comprises steps 1 and 2, step 1 is conducted with the mobile phase including the organic phase in a range of from 1 to 14% by volume, step 2 is conducted after step 1 and includes performing elution by applying a gradient of increasing the percentage of the organic phase in the mobile phase, the organic phase consists of at least one solvent and optionally 10% or less water, the aqueous phase consists of water and optionally 10% or less of at least one solvent, at least one of the related substances 1 to 5 is detected in the mobile phase of step 1, and the related substance 6 is detected in the mobile phase of step 2, where the related substances 1 to 6 are as follows: related substance 1: 5-carboxyuracil, related substance 2: 5-carboxy-2\u2032-deoxy-uridine, related substance 3: 2\u2032-deoxy-5-methoxycarbonyluridine, related substance 4: trifluorothymine, related substance 5: 5-methoxycarbonyluracil, and related sub stance 6: 5\u2032-(4-chlorophenylcarboxy)-2\u2032-deoxy-5-trifluoromethyluridine.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 95.0
- Lexical Diversity: 2.17143
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14083135', '14380924', '10621953', '15559428', '13933844']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6455244285809345
- 35 USC 102 Novelty (BERT): 0.4581712968961072
- Combined Prediction Score: 0.6267891154124517
- Mean Citation Score: 139.532772
- Max Citation Score: 149.06433
- Similarity Product: 108.3720243969977

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test