PATENT CLAIM ANALYSIS

Application Number: 16170487
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "167000"]

Abstract:
This present disclosure is directed to novel prodrugs of activated vitamin D 3  compounds. The prodrugs can be designed to have one or more beneficial properties, such as selective inhibition of the enzyme CYP24, low calcemic activity, and anti-proliferative activity. Specifically, these prodrugs are 1-deoxy prohormones of active Vitamin D analogs, e.g. analogs of calcitriol. This disclosure is also directed to pharmaceutical and diagnostic compositions containing the prodrugs of the invention, and to their medical use, particularly as prodrugs in the treatment and/or prevention of diseases.

Claim (Index 4):
The compound of  claim 3 , wherein\n R 1  is OH; R 5  and R 6  are each H, with the proviso that when   between carbon-23 and carbon-24 is a double bond, then R 5  is absent; R 7  is selected from the group consisting of H, C 1-4 alkyl, C 2-5 alkenyl, aryl and heteroaryl, with aryl and heteroaryl being unsubstituted or substituted with 1 to 5 groups independently selected from C 1-4 alkyl, OC 1-4 alkyl, OH, CF 3 , OCF 3 , and halo; and R 8  is selected from the group consisting of C 1-4 alkyl, aryl, and heteroaryl, with aryl, and heteroaryl, being unsubstituted or substituted with 1-5 groups independently selected from C 1-4 alkyl, OC 1-4 alkyl, OH, CF 3 , OCF 3 , and halo.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 97.0
- Lexical Diversity: 1.55556
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13521980', '10270158', '10612302', '11912395', '10738248']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8069987950791807
- 35 USC 102 Novelty (BERT): 0.6874977230530681
- Combined Prediction Score: 0.7950486878765695
- Mean Citation Score: 476.151318
- Max Citation Score: 735.80597
- Similarity Product: 669.5234111434853

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test