PATENT CLAIM ANALYSIS

Application Number: 16438877
Application Type: Utility
Filing Date: 2019-06
Publication Date: 2019-10
Patent Classification: ["435", "006170"]

Abstract:
Control Devices are disclosed including RNA destabilizing elements (RDE), RNA control devices, and destabilizing elements (DE) combined with Chimeric Antigen Receptors (CARs) or other transgenes in eukaryotic cells. Multicistronic vectors are also disclosed for use in engineering host eukaryotic cells with the CARs and transgenes under the control of the control devices. These control devices can be used to optimize expression of CARs in the eukaryotic cells so that, for example, effector function is optimized. CARs and transgene payloads can also be engineered into eukaryotic cells so that the transgene payload is expressed and delivered after stimulation of the CAR on the eukaryotic cell.

Claim (Index 34):
The method of  claim 21 , wherein the RDE in the transcript is bound by a glycolytic enzyme selected from the group consisting of a glyceraldehyde phosphate dehydrogenase, an enolase, a phosphoglycerate kinase, a triose phosphate isomerase, an aldolase A or a phosphoglycerate mutase.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 100.0
- Lexical Diversity: 1.81538
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16151138', '15692440', '15707242', '15070352', '16161542']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6843379763355258
- 35 USC 102 Novelty (BERT): 0.6229488535141204
- Combined Prediction Score: 0.6781990640533853
- Mean Citation Score: 393.50837
- Max Citation Score: 609.1745599999998
- Similarity Product: 523.6117806657791

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test