PATENT CLAIM ANALYSIS

Application Number: 15935155
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-09
Patent Classification: ["514", "233200"]

Abstract:
Novel heterocyclic systems are herein disclosed, which possess many biological activities, including but not limited to anticancer activity. The disclosed compounds are useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for their preparations and methods for their pharmaceutical applications, for example, as anticancer agents. These compounds were found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compounds also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, these novel compounds were able to target multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.

Claim (Index 24):
The compound of  claim 15 , wherein is an unsubstituted ring or a ring with 1, 2, 3, or 4 substituents independently selected from the group consisting of: a halogen atom, CN, R 1 , OR 1 , SR 1 , N(R 1 ) 2 , C(O)R 1 , C(O)OR 1 , NR 1 C(O)R 1 , C(O)NR 1 , SO 2 R 1 , NR 1 SO 2 R 1 , and SO 2 N(R 1 ) 2 .

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.51042
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15935120', '11562903', '14385808', '15256230', '14007306']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.784406516239959
- 35 USC 102 Novelty (BERT): 0.5526355042125806
- Combined Prediction Score: 0.7612294150372212
- Mean Citation Score: 341.295546
- Max Citation Score: 411.06458
- Similarity Product: 308.8003208228159

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test