PATENT CLAIM ANALYSIS

Application Number: 15746182
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-03
Patent Classification: ["544", "008000"]

Abstract:
The invention provides a series of chlorobenzene substituted azaaryl compounds having activity in inhibiting cancer cell growth and low toxicity to normal cells. Particularly, the compounds of the invention have stronger inhibition effect on bladder cancer and liver cancer.

Claim (Index 1):
A compounds having the following Formula (I): wherein X is C, N, O or S; R1 is cycloalkyl; aryl unsubstituted or substituted by halo, carbonyl, hydroxy, amino, nitro, cyano, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkoxyalkyl, alkylamino, or heteroaryl having 1 to 3 heteroatoms selected from the group consisting of N, O and S; heteroalkyl unsubstituted or substituted by halo, carbonyl, hydroxy, amino, nitro, cyano, alkoxy, alkylthio, alkoxyalkyl, alkylamino, or heteroaryl having 1 to 3 heteroatoms selected from the group consisting of N, O and S; or NR7R8 wherein R7 and R8 are each independently selected from the group consisting of H, nitro, amino, cyano, alkyl, alkenyl, alkynyl, aryl or heteroaryl wherein alkyl, alkenyl, alkynyl, aryl and heteroaryl are each independently substituted by heteroaryl having 1 to 3 heteroatom selected from the group consisting of N, O and S and substituted by alkyl, alkenyl or alkynyl or alkoxy; R2 is H, halo, carbonyl, hydroxy, amino, nitro, cyano, alkyl, alkenyl, alkynyl or aryl unsubstituted or substituted by halo, hydroxy, amino, nitro, cyano, alkyl, alkenyl or alkynyl; and R3 and R4 are each independently selected from the group consisting of alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkoxyalkyl or alkylamino; and R5 and R6 are each independently selected from H, halo, carbonyl, hydroxy, amino, nitro, cyano, alkyl, alkenyl, alkynyl; wherein the above-mentioned heteroaryl is unsubstituted or substituted by halo, carbonyl, hydroxy, amino, nitro, cyano, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkoxyalkyl, alkylamino or aryl; or a tautomer or stereoisomer thereof, or a solvate, prodrug or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.23529
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15230700', '13391148', '11570966', '13575799', '15181903']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7667568275253289
- 35 USC 102 Novelty (BERT): 0.5099406358218205
- Combined Prediction Score: 0.7410752083549781
- Mean Citation Score: 260.94092800000004
- Max Citation Score: 291.13596
- Similarity Product: 224.6436846774029

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test