PATENT CLAIM ANALYSIS

Application Number: 15943112
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "277000"]

Abstract:
The present invention relates to compositions and methods for cancer treatment comprising compounds of Formulae I, II, and III. In some aspects, the invention relates to the treatment of B-cell Lymphoma or other hematopoietic cancers. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as, for example, B-cell lymphoma, using a combination of one or more compounds of Formulae I, II, and III. Combination therapy with, for example, 26S proteasome inhibitors, such as, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formulae I, II, and III. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.

Claim (Index 26):
A method of predicting sensitivity of a cancer cell to a therapeutic agent comprising contacting mitochondria from the cell with a compound of any one of  claim 1 ,  6 , or  10 , and detecting cytochrome C release from the mitochondria, wherein the cytochrome C release indicates the cell is sensitive to the therapeutic agent.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 91.0
- Lexical Diversity: 2.35616
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15792095', '14003733', '14700875', '14624263', '12760380']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7895621239271409
- 35 USC 102 Novelty (BERT): 0.5398795379643547
- Combined Prediction Score: 0.7645938653308623
- Mean Citation Score: 348.29576799999984
- Max Citation Score: 387.6464
- Similarity Product: 230.8404245241165

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test