PATENT CLAIM ANALYSIS

Application Number: 15943685
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["424", "139100"]

Abstract:
The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.

Claim (Index 9):
The antibody-like binding protein of  claim 1 , wherein the second polypeptide chain comprises a structure represented by the formula [IV]:\n V D1 -L 1 -V D2 -L 2 -C L -L 5 -Fc 2 \u2003\u2003[IV] and the first polypeptide chain comprises a structure represented by the formula [III]:\n V D3 -L 3 -V D4 -L 4 -C H1 -Fc\u2003\u2003[III] \n wherein:\n V D1  is a light chain variable domain of a first immunoglobulin; \n V D2  is a light chain variable domain of a second immunoglobulin; \n V D3  is a heavy chain variable domain of the second immunoglobulin; \n V D4  is a heavy chain variable domain of the first immunoglobulin; \n C L  is a light chain constant domain of an immunoglobulin; \n C H1  is a C H1  heavy chain constant domain of an immunoglobulin; \n Fc is the immunoglobulin hinge region and CH 2 , CH 3  immunoglobulin heavy chain constant domains of a first immunoglobulin; \n Fc 2  is the immunoglobulin hinge region and CH 2 , CH 3  immunoglobulin heavy chain constant domains of a second immunoglobulin; \n L 1 , L 2 , L 3 , L 4 , and L 5  are amino acid linkers; and \n wherein the second polypeptide chain of formula [IV] and the first polypeptide chain of formula [III] form a cross-over light chain-heavy chain pair.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 91.0
- Lexical Diversity: 2.48
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14844194', '15141463', '14830392', '15195401', '12610204']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7422508967687405
- 35 USC 102 Novelty (BERT): 0.5577792351533244
- Combined Prediction Score: 0.7238037306071988
- Mean Citation Score: 381.694084
- Max Citation Score: 430.3978
- Similarity Product: 306.53243687862164

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test