PATENT CLAIM ANALYSIS

Application Number: 16100721
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "171000"]

Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Claim (Index 1):
A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n A is selected from the group consisting of:\n 1) Optionally substituted \u2014C 3 -C 12  cycloalkyl; \n 2) Optionally substituted \u2014C 3 -C 12  cycloalkenyl; \n 3) Optionally substituted 3- to 12-membered heterocycloalkyl; \n 4) Optionally substituted aryl; and \n 5) Optionally substituted heteroaryl; \n \n L is \u2014CH 2 \u2014, \u2014CO\u2014, or \u2014SO 2 \u2014; B is optionally substituted aryl or optionally substituted heteroaryl; R 1  is selected from the group consisting of:\n 1) Absent; \n 2) Optionally substituted \u2014C 1 -C 8  alkoxy; \n 3) Optionally substituted \u2014C 1 -C 8  alkyl; \n 4) Optionally substituted \u2014C 2 -C 8  alkenyl; \n 5) Optionally substituted \u2014C 2 -C 8  alkynyl; \n 6) Optionally substituted \u2014C 3 -C 12  cycloalkyl; \n 7) Optionally substituted \u2014C 3 -C 12  cycloalkenyl; \n 8) Optionally substituted 3- to 12-membered heterocycloalkyl; \n 9) Optionally substituted aryl; \n 10) Optionally substituted heteroaryl; \n 11) \u2014C(O)R 12 ; \n 12) \u2014C(O)NR 13 R 14 ; \n 13) \u2014C(O)NR 11 S(O) 2 R 12 ; \n 14) \u2014S(O) 2 NR 13 R 14 ; \n 15) \u2014NR 13 R 14 ; \n 16) \u2014NR 11 S(O) 2 R 12 ; \n 17) \u2014NR 11 C(O)R 12 ; \n 18) \u2014NR 11 C(O)NR 13 R 14 ; and \n 19) \u2014NR 11 C(O)NH S(O) 2 R 12 ; \n R 2  is selected from the group consisting of:\n 1) Optionally substituted \u2014C 1 -C 8  alkoxy; \n 2) Optionally substituted \u2014C 1 -C 8  alkyl; \n 3) Optionally substituted \u2014C 2 -C 8  alkenyl; \n 4) Optionally substituted \u2014C 2 -C 8  alkynyl; \n 5) Optionally substituted \u2014C 3 -C 12  cycloalkyl; \n 6) Optionally substituted \u2014C 3 -C 12  cycloalkenyl; \n 7) Optionally substituted 3- to 12-membered heterocycloalkyl; \n 8) \u2014C(O)R 12 ; \n 9) \u2014C(O)NR 13 R 14 ; \n 10) \u2014C(O)NR 11 S(O) 2 R 12 ; \n 11) \u2014S(O) 2 NR 13 R 14 ; \n 12) \u2014NR 13 R 14 ; \n 13) \u2014NR 11 S(O) 2 R 12 ; \n 14) \u2014NR 11 C(O)R 12 ; \n 15) \u2014NR 11 C(O)NR 13 R 14 ; and \n 16) \u2014NR 11 C(O)NHS(O) 2 R 12 ; \n Each R 3  is the same or different and independently selected from halogen, hydroxyl, protected hydroxyl, cyano, amino, protected amino, nitro, optionally substituted \u2014C 1 -C 8  alkyl, optionally substituted \u2014C 1 -C 8  alkoxy, and optionally substituted \u2014C 1 -C 8  alkyl-O\u2014C 1 -C 8  alkoxy; R 12  at each occurrence is independently selected from the group consisting of:\n 1) Hydrogen; \n 2) Halogen; \n 3) Hydroxyl; \n 4) Optionally substituted \u2014C 1 -C 8  alkoxy; \n 5) Optionally substituted \u2014C 1 -C 8  alkyl; \n 6) Optionally substituted \u2014C 2 -C 8  alkenyl; \n 7) Optionally substituted \u2014C 2 -C 8  alkynyl; \n 8) Optionally substituted \u2014C 3 -C 8  cycloalkyl; \n 9) Optionally substituted \u2014C 3 -C 8  cycloalkenyl; \n 10) Optionally substituted 3- to 8-membered heterocycloalkyl; \n 11) Optionally substituted aryl; \n 12) Optionally substituted arylalkyl; \n 13) Optionally substituted heteroaryl; and \n 14) Optionally substituted heteroarylalkyl; \n R 11 , R 13  and R 14  are each independently selected from hydrogen, optionally substituted \u2014C 1 -C 8 -alkyl, optionally substituted \u2014C 2 -C 8 -alkenyl, optionally substituted \u2014C 2 -C 8 -alkynyl; optionally substituted \u2014C 3 -C 8 -cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, and optionally substituted heteroarylalkyl; alternatively, R 13  and R 14  are taken together with the nitrogen atom to which they are attached to form a 3- to 12-membered heterocyclic ring; and n is 0, 1, 2, 3 or 4.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 96.0
- Lexical Diversity: 1.63265
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15216119', '15863216', '15914016', '15636424', '14830121']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8136104780087011
- 35 USC 102 Novelty (BERT): 0.5246430698169604
- Combined Prediction Score: 0.7847137371895271
- Mean Citation Score: 320.456024
- Max Citation Score: 349.63184
- Similarity Product: 313.29083211346625

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test