PATENT CLAIM ANALYSIS

Application Number: 15904254
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["530", "350000"]

Abstract:
Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

Claim (Index 2):
A composition for immunomodulation to achieve antigen-specific tolerance, the composition comprising:\n an antigen to which tolerance is desired;\n wherein the antigen is selected from the group consisting of high molecular weight glutenin, low molecular weight glutenin, gliadin, hordein, secalin, avenin, and immunogenic fragments thereof; \n an erythrocyte-binding moiety,\n wherein the erythrocyte-binding moiety has the ability to non-covalently, specifically bind an exterior erythrocyte surface in situ in blood, \n wherein the erythrocyte-binding moiety comprises an antibody, antibody fragment, or a single chain variable fragment (scFv) directed against glycophorin A, \n wherein the antigen to which tolerance is desired is recombinantly fused or chemically conjugated to the erythrocyte-binding moiety, and \n wherein, upon administration to a human in which tolerance to the antigen is desired:\n the composition binds to CD45 negative cells, but not to CD45 positive cells, and the composition reduces, fails to induce, or prevents inflammatory responses in antigen-specific T cells as compared to when the human is exposed to the antigen alone.

Metadata:
- Claim Count in Document: 51.0
- Percentile: 88.0
- Lexical Diversity: 1.38182
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15232713', '15904248', '15904228', '15232724', '15232714']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8153588150351481
- 35 USC 102 Novelty (BERT): 0.7026383466454772
- Combined Prediction Score: 0.804086768196181
- Mean Citation Score: 727.8368780000003
- Max Citation Score: 790.30615
- Similarity Product: 729.8481075028806

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test