PATENT CLAIM ANALYSIS

Application Number: 15763750
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["424", "133100"]

Abstract:
The group of inventions relates to biotechnology and medicine and concerns antibodies for treating oncological diseases. The antibodies of the invention specifically bind and block fibroblast growth factor receptor 1 (FGFR1) and are characterized by amino acid sequences H-CDR1, H-CDR2, H-CDR3, L-CDR1, L-CDR2 and L-CDR3. A pharmaceutical composition for treating oncological diseases which contains antibodies of the invention, and a method for treating oncological diseases which involves administering a patient with antibodies of the invention are proposed. Also proposed are: a method for producing antibodies; nucleic acids which encode said antibodies; and cell lines for producing said antibodies. The use of the group of inventions makes it possible, with high effectiveness and specificity, to suppress the proliferation of tumor cells and inhibit tumor angiogenesis by means of blocking the FGF/FGFR1 pathological pathway, which in turn makes it possible to effectively treat oncological diseases.

Claim (Index 39):
A method for producing the antibody or its functional fragment according to  claim 30 , comprising culturing a cell line comprising a nucleic acid encoding the antibody or its functional fragment according to  claim 30 , wherein said nucleic acid has at least one of the following characteristics:\n it has a sequence homologous to at least 90% of SEQ ID NO:11, preferably it has the SEQ ID NO:11 sequence; it has a sequence homologous to at least 90% of SEQ ID NO:12, preferably it has the SEQ ID NO:12 sequence; for the production of the antibody or its functional fragment according to  claim 30 , wherein the cell line preferably deposited in the Russian National Collection of Industrial Microorganisms under the registration number VKPM H-134 in the growth medium and isolating the antibody or its functional fragment from the aforesaid cells and/or the aforesaid medium.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 90.0
- Lexical Diversity: 1.87209
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14791698', '14391435', '15027489', '10734661', '13800713']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6695177430330737
- 35 USC 102 Novelty (BERT): 0.5186506016795964
- Combined Prediction Score: 0.654431028897726
- Mean Citation Score: 276.710338
- Max Citation Score: 282.16385
- Similarity Product: 189.27476228780748

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test