PATENT CLAIM ANALYSIS

Application Number: 15907480
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "006000"]

Abstract:
Provided herein are opto-genetic systems, cells, and methods thereof for modulating and regulating genetic expression in transiently active cells. The technologies described herein provide a transformative genetic regulatory tool for in vivo applications, which broadly spans a variety of disciplines, including behavioral, cognitive, and systems neuroscience.

Claim (Index 21):
A nucleic acid molecule comprising\n a nucleic acid sequence encoding a chimeric photosensitive transcription factor operably linked to a promoter, wherein the photosensitive transcription factor comprises a Herpes Virus VP-16 transactivation domain, a GAL4 DNA binding domain, and an  A. sativa  LOV photosensitive actuator domain; and a nucleic acid sequence encoding a gene of interest operably linked to an inducible promoter comprising at least one copy of a GAL4 UAS sequence and a DRE repressor binding element, wherein expression of the gene of interest in a cell comprising the system requires the presence of both intracellular calcium in the range of about 0.1 \u03bcM to about 5 \u03bcM and light in the range that activates the  A. sativa  photosensitive actuator domain.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.38462
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15036020', '14105017', '12771457', '14004879', '11115922']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5975352920245853
- 35 USC 102 Novelty (BERT): 0.4955586137100021
- Combined Prediction Score: 0.5873376241931271
- Mean Citation Score: 255.01408
- Max Citation Score: 261.08667
- Similarity Product: 196.7099407435298

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test