PATENT CLAIM ANALYSIS

Application Number: 15965489
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "249000"]

Abstract:
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Claim (Index 1):
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: Ring A is Ring B is wherein Ring B is optionally substituted with up to 4 fluorine atoms, up to two OH,or up to two C 1-4 alkyl, which is optionally substituted with up to 3 fluorine atoms, up to two OH, or up to two \u2014OC 1-2 alkyl groups;\n Ring C is a cyclohexane or a cyclobutane ring; \n X is \u2014NH\u2014, \u2014O\u2014, or \u2014OC 1-4  alkyl-; \n each of R 1  and R 2  is, independently, hydrogen, \u2014C(O)NHR 4 , \u2014C(O)OR 4 , \u2014NHC(O)R 4 , \u2014NHC(O)OR 4 , \u2014NHC(O)NHR 4 , \u2014NHS(O) 2 R 4 , \u2014C 0-4  alkyl\u2014NHR 4 , or \u2014OR 4 , wherein R 1  and R 2  cannot simultaneously be hydrogen, and wherein R 1  and R 2  and the intervening carbon atom can form a dioxane or dioxolane ring; \n R 3  is hydrogen, \u2014C 1-4 alkyl, fluoro, chloro, -OC 1-2 alkyl, \u2014C(O)H, \u2014C(O)OH, \u2014C(O)OC 1-2 alkyl, \u2014CN, \u2014C(O)NHC 1-2 alkyl, or \u2014C(O)NH 2 , wherein each of said R 3  alkyl is optionally substituted with up to 3 fluorine atoms, up to two OH, or up to two OC 1-2 alkyl groups; \n R 4  is hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-5 cycloalkyl, phenyl, a 5-10-membered monocyclic or bicyclic heteroaryl ring selected from pyrrole, imidazole, pyrazole, triazole, thiazole, isothiazole, oxazole, pyridine, pyrimidine, pyrimidinone, pyrazine, pyridazine, ef and quinoline, or a 4-10-membered monocyclic or bicyclic heterocyclyl ring selected from oxetane, tetrahydrofuran, tetrahydropyran, dihydroisoxazole, pyrimidine-2,4(1H,3H)-dione, dihydrofuropyrimidine, dihydropyranopyrimidine, dihydropyrrolopyrimidine, tetrahydropteridine, and tetrahydropyridopyrimidine, wherein each of said R 4  groups is optionally substituted with up to four Br, Cl, F, or C 1-4 alkyl, up to three CN, NO 2 , C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, C 0-4  alkyl-C 3-5  cycloalkyl, C 0-4  alkyl-O\u2014C 1-4  alkyl, C o4  alkyl-O-0 0-4  alkyl-C 3-5  cycloalkyl, C(O)OC 1-4  alkyl, C(O)OC 0-4  alkyl-C 3-5  cycloalkyl, C 0-4  alkyl-C(O)NH 2 , C(O)NHC 1-4  alkyl, C(O)N(C 1-4 alkyl) 2 , C(O)NH(C 0-4 alkyl-C 3-5  cycloalkyl), CH 2 OR 5 , C 0-4  alkyl-C(O)R 5 , C 0-4  alkyl-C(O)N(R 5 ) 2 , C 0-4  alkyl-C(O)OR 5 , C 0-4  alkyl\u2014NHC(O)R 5 , C 0-4  alkyl-N(R 5 ) 2 , a heterocyclic ring system selected from oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine ef and piperazine, a heteroaryl ring system selected from furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole ef and tetrazole, or up to two OR 5 , wherein each of said optional R 4  substituents is optionally substituted with up to four fluorine atoms, up to two C 1-4 alkyl groups, up to two OH groups, up to two OC 1-4 alkyl groups, up to two SC 1-4 alkyl groups, a C(O)C 1-4  alkyl, a C(O)OC 14  alkyl, or a C(O)OC 0-4  alkyl-C 3-5  cycloalkyl; and \n each R 5  is, independently, hydrogen, C 1-4 alkyl, a 5-6-membered heteroaryl selected from imidazole, triazole, thiazole, pyridine, and pyrimidine, or a 4-6-membered heterocyclyl selected from oxetane, tetrahydrofuran, and tetrahydropyran, and each R 5  group is optionally substituted with chloro, up to three fluorine atoms, up to two C 1-2 alkyl, CH 2 OH, CN, up to two OH, up to two OC 1-2 alkyl, a spirooxetane, pyrrolidine, or triazole, or two R 5  groups together with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 91.0
- Lexical Diversity: 1.29032
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15133378', '14205508', '15659306', '14205657', '15912074']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8021153381551445
- 35 USC 102 Novelty (BERT): 0.5538269949231892
- Combined Prediction Score: 0.777286503831949
- Mean Citation Score: 389.274834
- Max Citation Score: 397.28455
- Similarity Product: 391.74018479165136

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test