PATENT CLAIM ANALYSIS

Application Number: 15752507
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "604000"]

Abstract:
In one aspect, the present invention provides a method of inhibiting proliferation of a multiple myeloma cell, the method comprising contacting the cell with BRD9647, thereby inhibiting proliferation of the cell. In another aspect, the present invention provides a method of treating multiple myeloma in a pre-selected subject, the method comprising administering an effective amount of BRD9647 to the subject, wherein the subject is pre-selected by detecting a mutation in an AZIN1 polynucleotide or polypeptide relative to a reference in a biological sample obtained from the subject. In another aspect, the present invention provides a method of modulating benzoylation of an agent in a cell, the method comprising contacting the cell with BRD9647, thereby modulating benzoylation of an agent in the cell.

Claim (Index 34):
A method of inhibiting proliferation of a cancer cell, the method comprising covalently modifying a residue of a polypeptide in the cell, wherein the modification is addition or removal of a benzoyl group or a benzoyl derivative having the structure: wherein R 1 -R 5  are each independently selected from hydrogen, \u2014F; \u2014Cl; \u2014Br; \u2014I; \u2014OH; \u2014R*; \u2014OR*; \u2014NH 2 ; \u2014NHR*; \u2014N(R*) 2 ; \u2014N(R*) 3 + ; \u2014N(R*)\u2014OH; \u2014N(\u2192O)(R*) 2 ; \u2014O\u2014N(R*) 2 ; \u2014N(R*)\u2014O\u2014R*; \u2014N(R*)\u2014N(R*) 2 ; \u2014C\u2550N\u2014R*; \u2014N\u2550C(R*) 2 ; \u2014C\u2550N\u2014N(R*) 2 ; \u2014C(\u2550NR*)(\u2014N(R*) 2 ); \u2014C(H)(\u2550N\u2014OH); \u2014SH; \u2014SR*; \u2014CN; \u2014NC; \u2014C(\u2550O)\u2014R*; \u2014CHO; \u2014CO 2 H; \u2014CO 2 \u2212 ; \u2014CO 2 R*; \u2014C(\u2550O)\u2014S\u2014R*; \u2014O\u2014(C\u2550O)\u2014H; \u2014O\u2014(C\u2550O)\u2014R*; \u2014S\u2014C(\u2550O)\u2014R*; \u2014(C\u2550O)\u2014NH 2 ; \u2014C(\u2550O)\u2014N(R*) 2 ; \u2014C(\u2550O)\u2014NHNH 2 ; \u2014O\u2014C(\u2550O)\u2014NHNH 2 ; \u2014C(\u2550S)\u2014NH 2 ; \u2014(C\u2550S)\u2014N(R*) 2 ; \u2014N(R*)\u2014CHO; \u2014N(R*)\u2014C(\u2550O)\u2014R*; \u2014C(\u2550NR*)\u2014O\u2014R*; \u2014O\u2014C(\u2550NR*)\u2014R*; \u2014SCN; \u2014NCS; \u2014NSO; \u2014SSR*; \u2014N(R*)\u2014C(\u2550O)\u2014N(R*) 2 ; \u2014N(R*)\u2014C(\u2550S)\u2014N(R*) 2 ; \u2014S(\u2550O) 1-2 \u2014R*; \u2014O\u2014S(\u2550O) 2 \u2014R*; \u2014S(\u2550O) 2 \u2014OR*; \u2014N(R*)\u2014S(\u2550O) 2 \u2014R*; \u2014S(\u2550O) 2 \u2014N(R*) 2 ; \u2014O\u2014SO 3 ; \u2014O\u2014S(\u2550O) 2 \u2014OR*; \u2014O\u2014S(\u2550O)\u2014OR*; \u2014O\u2014S(\u2550O)\u2014R*; \u2014S(\u2550O)\u2014OR*; \u2014S(\u2550O)\u2014R*; \u2014NO; \u2014NO 2 ; \u2014NO 3 ; \u2014O\u2014NO; \u2014O\u2014NO 2 ; \u2014N 3 ; \u2014N 2 \u2014R*; \u2014N(C 2 H 4 ); \u2014Si(R*) 3 ; \u2014CF 3 ; \u2014O\u2014CF 3 ; \u2014O\u2014CH 3 ; \u2014O\u2014(CH 2 ) 1-6 CH 3 ; \u2014PR* 2 ; \u2014O\u2014P(\u2550O)(OR*) 2 ; and \u2014P(\u2550O)(OR*) 2 ; R* is, independently at each occurrence from hydrogen, and a C 1-10  hydrocarbon; wherein at least one of R 1 -R 5  is not hydrogen.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 88.0
- Lexical Diversity: 2.68
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14044457', '12086792', '13520619', '14670088', '14606938']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7528038120840915
- 35 USC 102 Novelty (BERT): 0.4986778713942245
- Combined Prediction Score: 0.7273912180151048
- Mean Citation Score: 225.917774
- Max Citation Score: 230.53688
- Similarity Product: 155.47953435359958

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test