PATENT CLAIM ANALYSIS

Application Number: 15864373
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-11
Patent Classification: ["514", "177000"]

Abstract:
The present method has anti-aging properties against high-glucose. The present invention reveals the anti-aging properties of antcin M (ANM) and elucidates the molecular mechanism underlying the effects. It is found that exposure of human normal dermal fibroblasts (HNDFs) to high-glucose (HG) for 3 days, cell phase arrest and senescence are accelerated. As confirmed through experiments, co-treatment with ANM significantly attenuates HG-induced growth arrest and promotes cell proliferation. In addition, treatment with ANM eliminates HG-induced reactive oxygen species through the induction of anti-oxidant genes via transcriptional activation of NF-E2 related factor-2 (Nrf2). Treatment with ANM abolishes HG-induced stress-induced premature senescence as evidenced by reduced senescence-associated β-galactosidase activity. Also, the HG-induced decline in aging-related marker protein, senescence marker protein-30, is rescued by ANM. Furthermore, treatment with ANM increases expression of silent mating type information regulation 2 homologs 1 (SIRT-1), and prevents SIRT-1 depletion.

Claim (Index 8):
The method according to  claim 7 , wherein said anti-oxidant genes comprises hemoxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase-1 (NQO-1).

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.5463
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13245988', '13700839', '14651267', '14009662', '12742250']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6918236430197094
- 35 USC 102 Novelty (BERT): 0.5173610539839651
- Combined Prediction Score: 0.6743773841161351
- Mean Citation Score: 165.889584
- Max Citation Score: 177.2621
- Similarity Product: 95.61989630351664

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test