PATENT CLAIM ANALYSIS

Application Number: 15981915
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["536", "029200"]

Abstract:
The present invention relates to pyrazolotriazolyl nucleoside analogues, oligonucleotide comprising them, and uses thereof. Further the invention relates to a method for reducing gene expression in a cell comprising transfecting the cell with such an oligonucleotide.

Claim (Index 1):
An oligonucleotide comprising one or more of 9-adeninyl or 9-guaninyl PT nucleoside or nucleotide analogues each independently of the general formula II: wherein R 1  and R 4  each independently is selected from H, halogen, \u2014CN, \u2014SCN, \u2014NO 2 , \u2014O-hydrocarbyl, \u2014S-hydrocarbyl, \u2014CO\u2014H, \u2014CO-hydrocarbyl, \u2014NR 8 R 9 , heteroaryl, and hydrocarbyl optionally substituted by one or more groups each independently is halogen, \u2014CN, \u2014SCN, or \u2014NO 2 , wherein R 8  and R 9  are each independently H, hydrocarbyl, and benzoyl, provided that at least one of R 8  and R 9  is not H; or R 8  and R 9  together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocyclic ring optionally containing 1-2 further heteroatoms selected from oxygen, nitrogen and sulfur; R2 is H or absent; R3 is O or \u2014NR 10 R 10\u2032 , wherein R 10  and R 10\u2032  are each independently H, hydrocarbyl, or \u2014CO-hydrocarbyl, provided that at least one of R 10  and R 10\u2032  is not H; provided that at least one of R 1  and R 3  is \u2014NR 8 benzoyl or \u2014NR 10 benzoyl, respectively;\n R 5  is halogen or \u2014OR 11 ; \n R 6  is \u2014OR 11 ; \n R 7  is \u2014OR 11 , a monophosphate moiety, or a phosphate linking moiety; \n R 11  each independently is (C 1 -C 8 )alkyl, (C 1 -C 8 )alkylene-OR 12 , (C 1 -C 8 )alkylene-SR 12 , or (C 1 -C 8 )alkylene-NR 12 R 13 , a hydroxyl protecting group, or a phosphoramidite moiety of the formula \u2014P(OR 14 )NR 15 R 16 , wherein R 12  and R 13  each independently is H or (C 1 -C 8 )alkyl, provided that at least one of R 12  and R 13  is not H, wherein R 14  is H or cyano-(C 1 -C 8 )alkyl, and R 15  and R 16  each independently is (C 1 -C 8 )alkyl; and \n the dotted line represents a potential double bond between the carbon atom at position 4 and either the nitrogen atom at position 3 or the radical R 3 , provided that, when R 2  is H, there is a double bond between the carbon atom at position 4 and R 3 , and when R 2  is absent, there is a double bond between the carbon atom at position 4 and the nitrogen atom at position 3.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.33333
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14403580', '09528110', '09565699', '14403581', '12192581']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6123072540571144
- 35 USC 102 Novelty (BERT): 0.5977460683457582
- Combined Prediction Score: 0.6108511354859788
- Mean Citation Score: 321.328756
- Max Citation Score: 520.20465
- Similarity Product: 498.071571254772

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test