PATENT CLAIM ANALYSIS

Application Number: 16000939
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["544", "328000"]

Abstract:
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.

Claim (Index 44):
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: comprising:\n (g) reacting Compound (A) \n with quinine and ethyl alcohol to form an adduct of quinine and Compound (C-1) (h) breaking the adduct of quinine and Compound (C-1) by treating the adduct with HCl to form Compound (C-1) or a pharmaceutically acceptable salt thereof; (i) epimerizing Compound (C-1) or a pharmaceutically acceptable salt thereof to form Compound (C) or a pharmaceutically acceptable salt thereof;\n (e) reacting Compound (C) or a pharmaceutically acceptable salt thereof with diphenylphosphoryl azide and benzyl alcohol to form Compound (D) \n wherein Cbz is carboxylbenzyl;\n (f) reacting Compound (D) or a pharmaceutically acceptable salt thereof with H 2  in the presence of a Pd catalyst on carbon (Pd(0)/C) to form Compound (F) \n or a pharmaceutically acceptable salt thereof;\n (c) reacting Compound (F) or a pharmaceutically acceptable salt thereof with Compound (G) \n to form Compound (H) or a pharmaceutically acceptable salt thereof;\n (d) hydrolyzing Compound (H) or a pharmaceutically acceptable salt thereof to form Compound (X) \n or a pharmaceutically acceptable salt thereof;\n (a) reacting Compound (X) or a pharmaceutically acceptable salt thereof with Compound (Y) \n in the presence of a palladium catalyst to form Compound (Z) or a pharmaceutically acceptable salt thereof; and\n (b) deprotecting the Ts group of Compound (Z) or a pharmaceutically acceptable salt thereof to form Compound (1) or a pharmaceutically acceptable salt thereof; and \n wherein:\n X 1  and X 2  are independently \u2014F or \u2014Cl; \n Ts is tosyl; and \n each R 1  is independently ethyl.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 94.0
- Lexical Diversity: 2.33333
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15807877', '15150459', '14666567', '15807984', '15177546']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7376682007370313
- 35 USC 102 Novelty (BERT): 0.4995634962642026
- Combined Prediction Score: 0.7138577302897484
- Mean Citation Score: 232.72749400000004
- Max Citation Score: 273.64502000000005
- Similarity Product: 209.52175025470143

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test