PATENT CLAIM ANALYSIS

Application Number: 15966642
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "007200"]

Abstract:
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue and a second K residue, at positions corresponding to position 26, and 37, respectively, of GLP-1(7-37) (SEQ ID NO: 1), and a maximum of eight amino acid changes as compared to GLP-1(7-37); which derivative comprises two protracting moieties attached to said first and second K residue, respectively, via a linker, wherein the protracting moiety is selected from Chem. 1: HOOC—(CH 2 ) x —CO-*, and Chem. 2: HOOC—C 6 H 4 —O—(CH 2 ) y —CO-*, in which x is an integer in the range of 8-16, and y is an integer in the range of 6-13; and the linker comprises Chem. 3: *—NH—(CH 2 ) q —CH[(CH 2 ) w —NR 1 R 2 ]—CO-*, which is connected at its CO-* end to the epsilon amino group of the first or the second K residue of the GLP-1 analogue, and wherein q is an integer in the range of 0-5, R 1  and R 2  independently represent *—H or *—CH 3 , and w is an integer in the range of 0-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel peptide and linker intermediates. The derivatives are potent, stable, protracted, and suitable for oral administration.

Claim (Index 1):
A derivative of a GLP-1 analogue,\n which analogue comprises a first K residue at a position corresponding to position 26 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1), and a maximum of eight amino acid changes as compared to GLP-1(7-37), which derivative comprises two protracting moieties attached to said first and second K residue, respectively, via a linker, wherein the protracting moiety is selected from Chem. 2, and Chem. 1: Chem. 2: HOOC\u2014C 6 H 4 \u2014O\u2014(CH 2 ) y \u2014CO\u2014* Chem. 1: HOOC\u2014(CH 2 ) x \u2014CO\u2014*, in which x is an integer in the range of 8-16, and y is an integer in the range of 6-13; and the linker comprises Chem. 3a: *\u2014NH\u2014(CH 2 ) q \u2014CH[(CH 2 ) w \u2014NR 1 R 2 ]\u2014CO\u2014* which is connected at its CO\u2014* end to the epsilon amino group of the first or the second K residue of the GLP-1 analogue, and wherein q is an integer in the range of 0-5, R 1  and R 2  independently represent *\u2014H or *\u2014CH 3 , and w is an integer in the range of 0-5; or a pharmaceutically acceptable salt, amide, or ester thereof.

Metadata:
- Claim Count in Document: 34.0
- Percentile: 91.0
- Lexical Diversity: 2.45161
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15404808', '14399087', '13883946', '15301960', '13882947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8508092188876621
- 35 USC 102 Novelty (BERT): 0.6771182478593399
- Combined Prediction Score: 0.83344012178483
- Mean Citation Score: 636.651352
- Max Citation Score: 695.37006
- Similarity Product: 649.5837411708641

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test