PATENT CLAIM ANALYSIS

Application Number: 15988947
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-03
Patent Classification: ["536", "024500"]

Abstract:
The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include methods of making and using such nanoparticles.

Claim (Index 14):
The pharmaceutically acceptable nanoparticle of  claim 1 , wherein the hydrophobic counter ion is selected from the group consisting of chlorpromazine, tamoxifen, clomiphene, raloxifene, tamoxifen citrate, toremifene, clomiphene citrate, toremifene citrate, verapamil, dilitiazem, amlodipine, nifedpine, verapamil hydrochloride, nimodipine, felodipine, nicardpine, nisoldipine clevidipine, isradipine, trandolapril/verapamil, desipramine, imipramine, amitriptyline, nortiptyline, clomipramine, doxepin, amoxapine, trimipramine, protriptyline, amiodarone, lidocaine, sotalol, dronedarone, flecainide, procainamide, propafenone, quinidine, dofetilide, mexiletine, ibutilide, disopyramide, paroxetine, fluoxetine, sertraline, escitalopram, citalopram, fluvoxamine, paroxetine hydrochloride, nefazodone, citalopram hydrobromide, escitalopram oxalate, olanzapine/fluoxetine, chlorcyclizine, amodiaquine, thioridazine, chloroquine, quinine, atovaquone/proguanil, atovaquone, fluoxetine, mefloquine, primaquine, quinacrine, quinidine, halofantrine, Chloroquine, monensin, chlorcyclizine, Antrafenine, Aripiprazole, Bifeprunox, Brexpiprazole, Cariprazine, Ciprofloxacin, Dapiprazole, Dropropizine, Elopiprazole, Etoperidone, Itraconazole, Ketoconazole, Levodropropizine, Mepiprazole, Mianserin, Naftopidil, Nefazodone, Niaprazine, Oxypertine, Posaconazole, Trazodone, Umespirone, Urapidil, Vesnarinone, Lubazodone, Acaprazine, Batoprazine, Bifeprunox, Vortioxetine, Vilazodone, Tolpiprazole, Sonepiprazole, Pardoprunox, Naphthylpiperazine, Naluzotan, Lorpiprazole, Flesinoxan, Fluprazine, Flibanserin, Ensaculin, Enpiprazole, Eltoprazine, Elopiprazole, UNC 7938, sphingosine, dodecylimidazole, bafilomycin A1, quinolones, Omeprazole, Esmoprazole, pantoprazole, lansoprazole, rabeprazole, dexiansoprazole, Brefeldin A, Golgicide, Dyasore, Pitstop, amodiaquine, EGA (4-bromobenzaldehyde N-(2,6-dimethylphenyl)semicarbazone), fluoxetine, paroxetine, sertraline, thioridazine, phenothiazine, promethazine, prochlorperzaine, trifluoperazine, fluphenazine, prochlorperzine, fluphenazine decanoate, promethazine hydrochloride, quinine, Calcimycin, mefloquine, aprindine, disopyramide, flecainide, lidocaine, mexiletine, pentisomide, propafenone, cyproheptadine azatadine, ketotifen, loratadine, pizotifen, amitriptyline, propranolol, rupatadine, deptropine, amisulpride, nortriptyline, cyclobenzaprine, octriptyline, butriptyline, iprindole, trimipramine, flavoxate, cinnarizine chlomipramine, fluoxetine, promazine, imipramine, sertraline, carbamazepine, ay9944, Clomipramine, clozapine, flecainide, haloperidol, ketoconazole, ofloxacin, perhexiline, sotalol, temoxiphen, zimelidine, Cyproheptadine, toremifene, fluphenazine, trifluoperazine, pizotyline, CGS 12066B, Prochlorperazine, Doxepin, ketotifen, lacidipine, sb 205607, lofepramine, mifepristone, clobenpropit, salmeterol, azelastine, azelastine, epinastine, desloratadine, am-251, indatraline, nelfinavir, haloperidol, benproperine, M-paroxetine, carvedilol, calcipotriol, perphenazine, phenothiazine, chlorprothixene, desipramine, tetracaine, ifenprodil, U18666A, and diphenhydramine.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 93.0
- Lexical Diversity: 1.18519
- Patent Class: 536.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14656899', '15860881', '13910328', '15118737', '14091343']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6812403799534706
- 35 USC 102 Novelty (BERT): 0.4996852366292267
- Combined Prediction Score: 0.6630848656210463
- Mean Citation Score: 272.850088
- Max Citation Score: 282.66974
- Similarity Product: 216.4111346225214

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test