PATENT CLAIM ANALYSIS

Application Number: 16057350
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["514", "249000"]

Abstract:
The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

Claim (Index 1):
A method of treating a condition associated with GPR6 in a subject, the method comprising:\n administering to the subject a therapeutically effective amount of the compound of formula I or a pharmaceutically acceptable salt thereof, wherein R 1  is selected from the group consisting of optionally substituted C 3-8  cycloalkyl, optionally substituted C 3-6  heterocyclyl, optionally substituted C 6-10  aryl, and optionally substituted C 1-10  heteroaryl; X 1  is N and X 2  is CH; or X 1  is CH and X 2  is N; or X 1  is N and X 2  is N; when X 1  is N, Z is selected from the group consisting of C 1-6  alkylene, C 1-6  haloalkylene, \u2014C(O)\u2014, and \u2014S(O) 2 \u2014; when X 1  is CH, Z is selected from the group consisting of C 1-6  alkylene, C 1-6  haloalkylene, \u2014O\u2014, \u2014C(O)\u2014, \u2014NH\u2014, \u2014S\u2014, \u2014S(O)\u2014, and \u2014S(O) 2 \u2014; q is 0, 1, or 2; s is 0, 1, or 2; R 2  is \u2014OR 5  or \u2014NR 6 R 7 ; R 3 , each time taken, is independently selected from the group consisting of C 1-6  alkyl, C 3-8  cycloalkyl, and trifluoromethyl; p is 0, 1, or 2; R 4 , each time taken, is independently selected from the group consisting of C 1-6  alkyl, hydroxy, and halo; r is 0 or 1; R 5  is selected from the group consisting of C 1-6  alkyl and C 3-8  cycloalkyl; R 6  is selected from the group consisting of hydrogen and C 1-6  alkyl; R 7  is selected from the group consisting of optionally substituted C 1-6  alkyl, C 3-8  cycloalkyl, optionally substituted C 6-10  aryl, optionally substituted C 1-10  heteroaryl, and optionally substituted C 3-6  heterocyclyl; X 3  is selected from the group consisting of CH and CR 4  and X 4  is NR 8 ; or X 3  is NR 8  and X 4  is selected from the group consisting of CH and CR 4 ; R 8  is selected from the group consisting of C 1-6  alkyl, C 1-6  haloalkyl, C 3-8  cycloalkyl, \u2014S(O) 2 \u2014R 9 , \u2014C(O)\u2014R 10 , \u2014C(O)\u2014N(R 11 )(R 12 ), and \u2014C(O)\u2014OR 13 ; R 9  is selected from the group consisting of C 1-6  alkyl, C 3-8  cycloalkyl, and optionally substituted phenyl; R 10  is selected from the group consisting of hydrogen, optionally substituted C 1-6  alkyl, C 3-8  cycloalkyl, optionally substituted C 6-10  aryl, optionally substituted C 1-10  heteroaryl, and optionally substituted C 3-6  heterocyclyl; R 11  is selected from the group consisting of hydrogen and C 1-6  alkyl; R 12  is selected from the group consisting of hydrogen, C 1-6  alkyl and C 3-8  cycloalkyl; or R 11  and R 12  are taken together with the nitrogen to which they are attached form a 4 to 7 membered, saturated, ring optionally having 1 additional ring heteroatom selected from the group N, O, and S and optionally substituted on any of the ring carbon atoms with 1 to 5 substituents independently selected from the group consisting of cyano, halo, hydroxy, amino, optionally substituted C 3-6  heterocyclyl, C 1-9  amide, optionally substituted C 1-6  alkyl, and C 1-4  alkoxy and substituted on any additional ring nitrogen by a substituent selected from the group consisting of hydrogen, C 3-8  cycloalkyl, and optionally substituted C 1-6  alkyl; R 13  is selected from the group consisting of C 1-6  alkyl and C 3-8  cycloalkyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.25806
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14577480', '14883174', '15118447', '15118461', '15334198']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7828921480037478
- 35 USC 102 Novelty (BERT): 0.6084392124128862
- Combined Prediction Score: 0.7654468544446618
- Mean Citation Score: 447.3881960000001
- Max Citation Score: 600.1733
- Similarity Product: 449.8797420511306

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test