PATENT CLAIM ANALYSIS

Application Number: 16142422
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["607", "072000"]

Abstract:
Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.

Claim (Index 2):
The method of  claim 1  further comprising:\n adjusting the target treatment energy based on a comparison of a measured immune response biomarker before the applying and a measured immune response biomarker after the applying in a sample of the subject; \n determining a new number of pulses, a new amplitude, or a new pulse length based on the adjusted target treatment energy; and \n treating the tumor again by:\n applying to the tumor, using the plurality of electrodes, sub-microsecond pulsed electric fields based on the new determined number of pulses, the new determined amplitude, or the new determined pulse length.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 97.0
- Lexical Diversity: 1.90278
- Patent Class: 607.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14805828', '14287957', '15873810', '14954630', '15671014']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7151314037806232
- 35 USC 102 Novelty (BERT): 0.6237627129061503
- Combined Prediction Score: 0.705994534693176
- Mean Citation Score: 545.2034259999998
- Max Citation Score: 689.4032
- Similarity Product: 515.5573631222726

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test