PATENT CLAIM ANALYSIS

Application Number: 16123430
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["514", "024000"]

Abstract:
The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum based compounds, nanoparticles and compositions comprising said platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid carbene compounds, platinum based compounds, nanoparticles and compositions thereof.

Claim (Index 10):
The compound of  claim 1 , that is of Formula (VIII):\n Q-linker-lipid\u2003\u2003(VIII) wherein:\n Q is\n (i) \n \n wherein:\n X is NH or N(CH 2 COO \u2212 ); and \n Z is a platinum containing compound, wherein the platinum forms a part of the ring; \n (ii) wherein:\n X is S + , C, S + \u2550O, N + H, or P\u2550O; \n X 1  is \u2014CH, \u2014CH 2  or \u2014CH 2 O; \n X 2  is C\u2550O; and \n Z is a platinum containing compound, wherein the platinum forms a part of the ring; \n (iii) wherein:\n X 1  is (CH 2 ) n ; \n X 2  is C\u2550O; \n Z is a platinum containing compound, wherein the platinum forms a part of the ring; and \n n is 0, 1, or 2; \n (iv) wherein:\n R 1 , R 2  and R 3  are, independently, halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, -linker-lipid, or a combination thereof; \n or R 1  and R 2  together with the Pt atom or R 2  and R 3  together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; \n or R 1  and R 2  together with the Pt atom and R 2  and R 3  together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; or \n (v) wherein:\n R 1 , R 2 , R 3 , R 4  and R 5  are, independently, halogen, alkyl, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, thiol, thioalkyl, O-acyl, -linker-lipid, or a combination thereof; \n or R 1  and R 2  together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; \n or R 3  and R 4  together with the Pt atom form an optionally substituted cyclyl or heterocyclyl; and \n the linker is one of (a)-(d):\n (a) \u2014X\u2014CH 2 \u2014X 2 \u2014X 1 \u2014, wherein:\n X is NH; \n X 1  is C(O)O, C(O)NH, O(CH 2 )O, NH, or O; \n X 2  is (CH 2 ) n  or C(O); and \n n is 0, 1, 2, 3, 4, or 5; \n \n (b) \u2014(CH 2 ) n O\u2014, \u2014(CH 2 ) n NHC(O)O\u2014, \u2014(CH 2 ) n OC(O)NH\u2014, \u2014(CH 2 ) n C(O)NH(CH 2 ) m O\u2014, \u2014(CH 2 ) n O(CH 2 ) m O\u2014, \u2014(CH 2 ) n OC(O)\u2014, \u2014(CH 2 ) n NHC(O)(CH 2 ) m O\u2014, or \u2014(CH 2 ) n C(O)O\u2014; wherein n and m are, independently, 0, 1, 2, 3, 4, or 5; \n (c) \u2014X 3 \u2014X 4 X 5 \u2014X 6 \u2014, wherein:\n X 3  is CH, CH 2 , or O; and \n X 4 , X 5  and X 6  are, independently, the same or different and are \u2014CH 2 O\u2014 or O; or \n \n (d) a combination of (i), (ii), or (iii).

Metadata:
- Claim Count in Document: 77.0
- Percentile: 97.0
- Lexical Diversity: 2.07317
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14898355', '14897565', '13147751', '15182967', '11595653']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7978230138241245
- 35 USC 102 Novelty (BERT): 0.6144401577488997
- Combined Prediction Score: 0.7794847282166021
- Mean Citation Score: 348.906232
- Max Citation Score: 578.1692
- Similarity Product: 493.8047959306717

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test