PATENT CLAIM ANALYSIS

Application Number: 15775716
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-01
Patent Classification: ["514", "274000"]

Abstract:
The invention relates to 4-(4-Cyano-2-thioaryl)dihydropyrimidinones of the formula (I) known from WO 2009/080199(A1) for use in a method for the treatment and/or recurrence rate reduction of a chronic wound selected from different types of ulcers and a chronic wound associated with Behçet's disease wherein the compound of the formula (I) is administered orally and wherein the treatment and/or reduction of recurrence rate of the chronic wound causes one or more of the effects selected from an increased wound closure rate, a reduced wound size, a shorter time to wound closure, an increase of the reepithelialisation of the chronic wound, an increase of the deposition of extracellular matrix such as collagen in the chronic wound, and a reduction of pain related to the chronic wound. The invention further relates to compounds of the formula (I) for use in a method for the treatment of neutrophilic dermatoses or for use in a method for the treatment of autoimmune blistering dermatoses.

Claim (Index 11):
Medicament, comprising a compound of the formula (I) as defined in any of  claims 1  and  4  to  7  in combination with a further active compound selected from the group consisting of lipid metabolism-modulating active compounds, antidiabetics, perfusion-enhancing and/or antithrombotic agents and also antioxidants, aldosterone and mineralocorticoide receptor antagonists, vasopressin receptor antagonists, organic nitrates and NO donors, IP receptor agonists, EP receptor agonists and antagonists, positive inotropic compounds, ACE inhibitors, cGMP- and cAMP-modulating compounds, natriuretic peptides, NO-independent stimulators of guanylate cyclase, NO-independent activators of guanylate cyclase, compounds which inhibit proinflammatory signal transduction cascades, soluble guanylate cyclase (sGC) stimulators or inhibitors, chemokine receptor antagonists, p38 kinase inhibitors, NPY agonists, orexin agonists, anorectics, PAF-AH inhibitors, antiphlogistics, analgesics, AR alpha 2c antagonists, MMP inhibitors, glucocorticoid receptor agonists HIF PH inhibitors, oxidative stress modulators, and pH modulators, systemic or intra/perilesional applied growth factors or systems consisting of living keratinocytes and/or growth factors, topically applied, e.g. as foam or spray, for the treatment and/or recurrence rate reduction of a chronic wound selected from the group consisting of a pressure ulcer, a diabetic ulcer on the extremities, a venous leg ulcer, an arterial leg ulcer, a mixed leg ulcer, and a chronic wound associated with Beh\u00e7et's disease, wherein the compound of the formula (I) is administered orally and wherein the treatment of the chronic wound causes one or more of the effects selected from increased wound closure rates, shorter time to wound closure, an increase of the reepithelialisation of the chronic wound, an increase of the deposition of extracellular matrix such as collagen in the chronic wound, and a reduction of pain related to the chronic wound.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 93.0
- Lexical Diversity: 2.38667
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14522510', '12357821', '15205689', '10322068', '15106284']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7187516542080021
- 35 USC 102 Novelty (BERT): 0.4622548163309641
- Combined Prediction Score: 0.6931019704202983
- Mean Citation Score: 149.45419399999997
- Max Citation Score: 155.61389
- Similarity Product: 127.6210396031022

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test