PATENT CLAIM ANALYSIS

Application Number: 16095822
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-06
Patent Classification: ["514", "210210"]

Abstract:
The present invention relates to a substituted purine derivative of formula (1) wherein R 1  is alkoxy or the like, R 2  is alkyl or the like, Ring Q 1  is aryl or the like, W 1  is alkylene or the like, Ring Q 2  is aromatic carbocyclyl or the like, n is 1-4, R 3  is hydrogen atom or the like, X 1  is single bond or the like, W 2  is alkylene or the like, and R 4  is hydrogen atom or the like, or a pharmaceutically acceptable salt thereof, which has a potent inhibitory effect against TLR7, and thereby is useful for treating autoimmune disease.

Claim (Index 19):
The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein formula (1) is represented as formula (1a): wherein R 11  is C 1-6  alkoxy (which may be substituted with 1-3 the same or different substituents selected from the group consisting of halogen atom, hydroxy, C 1-6  alkoxy, C 3-7  cycloalkyl and 4- to 7-membered saturated heterocyclyl), 4- to 10-membered saturated heterocyclyloxy (which may be substituted with 1-4 the same or different substituents selected from the group consisting of halogen atom, and C 1-6  alkyl), C 1-6  alkyl (which may be substituted with 1-3 the same or different substituents selected from the group consisting of halogen atom, hydroxy, and C 1-6  alkoxy), 4- to 10-membered saturated heterocyclyl (which may be substituted with 1-4 the same or different substituents selected from the group consisting of halogen atom, C 1-6  alkyl, and C 1-6  alkoxy), amino (which may be substituted with 1-2 the same or different C 1-6  alkyl), halogen atom, or hydroxy; R 12  is C 1-6  alkyl or amino; Ring Q 11  is  (1) C 6-10  aryl which may be substituted with 1-5 the same or different substituents selected from the group consisting of (a) halogen atom, (b) cyano, (c) C 1-6  alkyl which may be substituted with 1-3 the same or different substituents selected from the group consisting of halogen atom, hydroxy, C 1-6  alkoxy, and 4- to 7-membered saturated heterocyclyl, (d) C 1-6  alkylsulfonyl, (e) C 1-6  alkoxy which may be substituted with 1-3 the same or different substituents selected from the group consisting of halogen atom, hydroxy, and 4- to 7-membered saturated heterocyclyl, and (f) amino which may be substituted with 1-2 the same or different C 1-6  alkyl, or (2) 5- to 10-membered heteroaryl which may be substituted with 1-4 the same or different substituents selected from the group consisting of (a)-(f) in the above (1) C 6-10  aryl; Ring Q 12  is benzene ring group, or 5- or 6-membered aromatic heterocyclyl; R 13  is hydrogen atom, halogen atom, hydroxy, C 1-6  alkyl (which may be substituted with 1-3 the same or different halogen atoms), or C 1-6  alkoxy (which may be substituted with 1-3 the same or different halogen atoms); Q 12 -X 11 \u2014 is Q 12 -(single bond)-, Q 12 -(CH 2 ) m \u2014O\u2014, Q 12- (CH 2 ) m \u2014C(O)\u2014, Q 12 -(CH 2 ) m \u2014NR a \u2014, or Q 12 -(CH 2 ) m \u2014C(O)NR a \u2014, wherein R a  is hydrogen atom or C 1-6  alkyl; m is 0, 1, or 2; W 12  is single bond or C 1-3  alkylene; and R 14  is (1) hydrogen atom, (2) \u2014OR b  wherein R b  is hydrogen atom, C 1-6  alkyl, or C 1-6  alkylsulfonyl, (3) \u2014NR c R d  wherein R c  and R d  are independently hydrogen atom, or C 1-6  alkyl which may be substituted with 1-3 the same or different halogen atoms, (4) 4- to 10-membered saturated heterocyclyl which may be substituted with 1-4 the same or different substituents selected from the group consisting of (a) halogen atom, (b) hydroxy, (d) C 1-6  alkyl which may be substituted with 1-3 the same or different substituents selected from the group consisting of halogen atom, hydroxy, and C 1-6  alkoxy, (e) C 1-6  alkoxy which may be substituted with 1-3 the same or different substituents selected from the group consisting of halogen atom, hydroxy, and C 1-6  alkoxy, (f) C 3-7  cycloalkyl, (g) C 1-6  alkylcarbonyl which may be substituted with 1-3 the same or different substituents selected from the group consisting of halogen atom, hydroxy, amino (which may be substituted with 1-2 the same or different C 1-6  alkyl), and C 1-6  alkoxy, (h) C 1-6  alkoxycarbonyl, (i) 4- to 7-membered saturated heterocyclyl which may be substituted with 1-4 the same or different substituents selected from the group consisting of halogen atom, C 1-6  alkyl, and C 1-6  alkoxy, and (j) oxo, or (5) 5- to 10-membered heteroaryl which may be substituted with 1-4 the same or different substituents selected from the group consisting of halogen atom, C 1-6  alkyl, and C 1-6  alkoxy.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 97.0
- Lexical Diversity: 2.08475
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13508905', '13819881', '13395429', '13380376', '11547036']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8125859885296864
- 35 USC 102 Novelty (BERT): 0.5412626686990982
- Combined Prediction Score: 0.7854536565466277
- Mean Citation Score: 368.977162
- Max Citation Score: 377.30194
- Similarity Product: 335.2839941583848

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test