PATENT CLAIM ANALYSIS

Application Number: 15901496
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "400000"]

Abstract:
Formulations, are used for eye treatments, e.g., cross-linking treatments. For example, a therapeutic formulation includes a photosensitizer and delivery agent(s), wherein the delivery agent(s) include at least one of: anesthetic agent(s), analgesic agent(s), tonicity agent(s), or shear-thinning, or viscosity-increasing agent(s). In another example, a method includes applying preparatory formulation(s) to increase a permeability of a corneal epithelium, and applying therapeutic formulation(s) to the epithelium, where the preparatory formulation(s) include zinc metalloproteinase, copper metalloproteinase, papain, bromelain, actinidin, ficain, N-acetylcysteine, ambroxol, carbocisteine, and/or erdosteine. In yet another example, a method includes applying therapeutic formulation(s) to a corneal epithelium to deliver the therapeutic formulation(s) to a stroma, and applying enhancement formulation(s) to the epithelium in response to applying the therapeutic formulation(s), where: the enhancement formulation(s) remove the therapeutic formulation(s) from the epithelium; close tight junctions of the epithelium; promote oxidation for the therapeutic agent(s); and/or further deliver the therapeutic formulation(s) to the stroma.

Claim (Index 15):
A method for treating an eye, comprising:\n applying one or more therapeutic formulations to an epithelium of a cornea to deliver the one or more therapeutic formulations to a stroma of the cornea; and applying one or more enhancement formulations to the epithelium in response to applying the one or more therapeutic formulations, the one or more enhancement formulations configured to at least one of:\n remove the one or more therapeutic formulations from the epithelium of the cornea without diluting the one or more therapeutic agents delivered to the stroma; \n close tight junctions of the epithelium to control hydration of the cornea; \n promote oxidation for the one or more therapeutic agents delivered to the stroma; or \n further deliver the one or more therapeutic formulations from the epithelium to the stroma.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 88.0
- Lexical Diversity: 3.12
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15369647', '12897131', '15137748', '15161302', '15486778']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7107272650310027
- 35 USC 102 Novelty (BERT): 0.4822052452332187
- Combined Prediction Score: 0.6878750630512243
- Mean Citation Score: 204.663792
- Max Citation Score: 207.0497
- Similarity Product: 156.7541903416634

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test