PATENT CLAIM ANALYSIS

Application Number: 15773512
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["424", "189100"]

Abstract:
The present application provides immunotherapies for Hepatitis B virus infections. Provided herein are genetically modified arenaviral vectors suitable as vaccines for prevention and treatment of Hepatitis B virus infections. Also provided herein are pharmaceutical compositions and methods for the treatment of Hepatitis B virus infections. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of treating Hepatitis B virus infection.

Claim (Index 33):
A pharmaceutical composition comprising a first infectious, replication-deficient arenavirus viral vector engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells, wherein one arenavirus open reading frame is removed and replaced by a first nucleotide sequence selected from the group consisting of:\n a. a nucleotide sequence encoding an HBV pre-S2/S protein or an antigenic fragment thereof; b. a nucleotide sequence encoding an HBV HBc protein or an antigenic fragment thereof; c. a nucleotide sequence encoding an HBV HBs protein or an antigenic fragment thereof; d. a nucleotide sequence encoding a fusion of HBV HBs and HBc proteins or antigenic fragments thereof; and e. a nucleotide sequence encoding an HBV HBe protein or an antigenic fragment thereof; and a second infectious, replication-deficient arenavirus viral vector engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells, wherein one arenavirus open reading frame is removed and replaced by a second nucleotide sequence selected from the group consisting of: a. a nucleotide sequence encoding an HBV pre-S2/S protein or an antigenic fragment thereof; b. a nucleotide sequence encoding an HBV HBc protein or an antigenic fragment thereof; c. a nucleotide sequence encoding an HBV HBs protein or an antigenic fragment thereof; d. a nucleotide sequence encoding a fusion of HBV HBs and HBc proteins or antigenic fragments thereof; and e. a nucleotide sequence encoding an HBV HBe protein or an antigenic fragment thereof.

Metadata:
- Claim Count in Document: 55.0
- Percentile: 93.0
- Lexical Diversity: 1.91429
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15101363', '15580964', '14775484', '13037931', '12810382']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7574181880152117
- 35 USC 102 Novelty (BERT): 0.561942931022035
- Combined Prediction Score: 0.7378706623158939
- Mean Citation Score: 372.36386
- Max Citation Score: 449.82828
- Similarity Product: 378.84400156030654

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test