PATENT CLAIM ANALYSIS

Application Number: 16045366
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["703", "011000"]

Abstract:
Methods for assessing the consistency and reliability of the calculations using cycle closures in relative binding free energy calculation paths. The methods are used for determining relative strength of binding between a receptor and individual members of a set ligands to form complexes between individual ligand set members and the receptor, in which the binding free energy difference with the lowest error is determined by probabilistic determination of the free energy differences and error distributions about those differences along each of the legs of the closed thermodynamic cycle that probabilistically lead to the hysteresis(es) value(s) observed for each closed of the closed thermodynamic cycle.

Claim (Index 10):
The method of  claim 2 , wherein the connectivity of the closed thermodynamic cycles is represented as a matrix.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 95.0
- Lexical Diversity: 1.68657
- Patent Class: 703.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['10844258', '12791493', '12791448', '11982783', '11695494']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.2778317220235754
- 35 USC 102 Novelty (BERT): 0.506241722103076
- Combined Prediction Score: 0.3006727220315255
- Mean Citation Score: 214.15502200000003
- Max Citation Score: 241.59618
- Similarity Product: 160.62052496058226

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test