PATENT CLAIM ANALYSIS

Application Number: 15746254
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["540", "001000"]

Abstract:
Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.

Claim (Index 3):
The fused ring pyrimidine compound, the tautomer, the enantiomer, the diastereoisomer, the pharmaceutically acceptable salt, the metabolite, the metabolic precursor or the prodrug thereof according to  claim 2 , wherein, in the case where each of R 1 , R 2 , R 3  and R 6  is independently \u201ca substituted or unsubstituted alkyl\u201d, the alkyl is a methyl;\n and/or, in the case where each of R 1 , R 2 , R 3  and R 6  is independently a heterocycloalkyl, the heterocycloalkyl is \u201ca heterocycloalkyl with 1-4 heteroatoms and 3-6 carbon atoms in which the heteroatom is oxygen and/or nitrogen\u201d; and/or, in the case where each of R 7 , R 8 , R 9.  R 10  and R 15  is independently \u201ca substituted or unsubstituted alkyl\u201d, the alkyl is a C 1-4  alkyl; and/or, in the case where each of R 7 , R 8 , R 9 , R 10  and R 15  is independently an alkoxy, the alkoxy is a C 1-4  alkoxy; and/or, in the case where each of R 7 , R 8 , R 9 , R 10  and R 15  is independently a heterocycloalkyl, the heterocycloalkyl is \u201ca heterocycloalkyl with 1-4 heteroatoms and 3-6 carbon atoms in which the heteroatom is oxygen and/or nitrogen\u201d; and/or, in the case where each of R 7 , R 8 , R 9. R 10  and R 15  is independently R 11  is a methyl;\n and/or, in the case where R 4  is \u201ca substituted or unsubstituted alkyl\u201d, the alkyl is a methyl, an ethyl, a propyl or an isopropyl; \n and/or, in the case where R 4  is \u201ca substituted or unsubstituted heterocycloalkyl\u201d, the heterocycloalkyl is \u201ca heterocycloalkyl with 1-4 heteroatoms and 3-6 carbon atoms in which the heteroatom is oxygen and/or nitrogen\u201d; \n and/or, in the case where R 5  is an alkyl, the alkyl is a methyl; \n and/or, the \u201c5- to 7-membered carbon heterocycle\u201d in \u201csubstituted or unsubstituted 5- to 7-membered carbon heterocycle\u201d is \n and/or, in the case where each of R 1 , R 2 , R 3  and R 6  is independently \u201ca substituted or unsubstituted alkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d is a C 1-4  alkyl; and/or, in the case where each of R 1 , R 2 , R 3  and R 6  is independently \u201ca substituted or unsubstituted alkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d is a C 1-4  alkoxy; and/or, in the case where each of R 1 , R 2 , R 3  and R 6  is independently \u201ca substituted or unsubstituted alkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d is \u201ca heterocycloalkyl with 1-4 heteroatoms and 3-6 carbon atoms in which the heteroatom is oxygen and/or nitrogen\u201d; and/or, in the case where each of R 1 , R 2 , R 3  and R 6  is independently \u201csubstituted or unsubstituted alkyl\u201d, the substituent in \u201csubstituted or unsubstituted alkyl\u201d is wherein R 12  is a methyl;\n and/or, in the case where each of R 7 , R 8 , R 9 , R 10  and R 15  is independently \u201ca substituted or unsubstituted alkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d is a C 1-4  alkyl; \n and/or, in the case where each of R 7 , R 8 , R 9 , R 10  and R 15  is independently \u201ca substituted or unsubstituted alkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d is a C 1-4  alkoxy; \n and/or, in the case where each of R 7 , R 8 , R 9 , R 10  and R 15  is independently \u201ca substituted or unsubstituted alkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d is \u201ca heterocycloalkyl with 1-4 heteroatoms and 3-6 carbon atoms in which the heteroatom is oxygen and/or nitrogen\u201d; \n and/or, in the case where each of R 1 , R 2 , R 3  and R 6  is independently \u201ca substituted or unsubstituted alkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d is \n wherein R 13  is a methyl;\n and/or, in the case where R 4  is \u201ca substituted or unsubstituted alkyl\u201d or \u201ca substituted or unsubstituted heterocycloalkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d or \u201ca substituted or unsubstituted heterocycloalkyl\u201d is a methyl; \n and/or, in the case where R 4  is \u201ca substituted or unsubstituted alkyl\u201d or \u201ca substituted or unsubstituted heterocycloalkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d or \u201ca substituted or unsubstituted heterocycloalkyl\u201d is \n and/or, in the case where R 4  is \u201ca substituted or unsubstituted alkyl\u201d or \u201ca substituted or unsubstituted heterocycloalkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d or \u201ca substituted or unsubstituted heterocycloalkyl\u201d is wherein R 14  is a methyl;\n and/or, in the case where R 4  is \u201ca substituted or unsubstituted alkyl\u201d or \u201ca substituted or unsubstituted heterocycloalkyl\u201d, the substituent in \u201ca substituted or unsubstituted alkyl\u201d or \u201ca substituted or unsubstituted heterocycloalkyl\u201d is \n wherein R 14  is a tert-butoxy or an ethoxy;\n and/or, in the case where the alkyl substituent in \u201csubstituted or unsubstituted 5- to 7-membered carbon heterocycle\u201d is a methyl, an ethyl or a propyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.83582
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14391386', '15025618', '15559181', '15568999', '15314938']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.747853990504253
- 35 USC 102 Novelty (BERT): 0.5296331062341821
- Combined Prediction Score: 0.726031902077246
- Mean Citation Score: 330.97676
- Max Citation Score: 348.54816
- Similarity Product: 297.58699068614965

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test