PATENT CLAIM ANALYSIS

Application Number: 16031193
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "275000"]

Abstract:
The present invention relates to pyrimidine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.

Claim (Index 1):
A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein: R 1  is a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; R 2  is hydrogen, C 1-6  aliphatic, C 5-10  aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; or R 1  and R 2  taken together with the atom to which they are attached, forms a 3-7 membered heterocylic ring having 1 nitrogen and 0-3 other heteroatoms independently selected from nitrogen, oxygen, or sulfur; or a 6-10 membered fused or spiro bicyclic heterocylic ring having 1 nitrogen and 0-3 other heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted;\n wherein R 1  or the ring formed by R 1  and R 2  is substituted with \n R 4  is hydrogen, C 1-6  aliphatic, C 5-10  aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; each R 5  is independently C 1-6  alkyl, C 5-10  aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; m is 0 or 1; X is O, S, SO 2 , SO, \u2014NRC(O), \u2014NRSO 2 , or N(R); each R 3  is independently \u2014R, halogen, \u2014OR, \u2014SR, \u2014CN, \u2014NO 2 , \u2014SO 2 R, \u2014SOR, \u2014C(O)R, \u2014CO 2 R, \u2014C(O)N(R) 2 , \u2014NRC(O)R, \u2014NRC(O)N(R) 2 , \u2014NRSO 2 R, or \u2014N(R) 2 ; each R is independently hydrogen, C 1-6  aliphatic, C 5-10  aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; or two R groups on the same atom are taken together with the atom to which they are attached to form a C 5 10  aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; and n is 1, 2, or 3.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 95.0
- Lexical Diversity: 1.05556
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15205136', '15499460', '14904547', '14876224', '15677272']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8237614204147976
- 35 USC 102 Novelty (BERT): 0.5570121740392064
- Combined Prediction Score: 0.7970864957772386
- Mean Citation Score: 402.660148
- Max Citation Score: 417.966
- Similarity Product: 407.181360432744

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test