PATENT CLAIM ANALYSIS

Application Number: 16063370
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-02
Patent Classification: ["514", "339000"]

Abstract:
The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R 1 , R 2 , R 3 , R 4  and R 5  are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.

Claim (Index 9):
The compound according to  claim 1 , which is selected from the group consisting of:\n tert-butyl 4-[(2-{[6-(2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; cyclopropyl{4-[(2-{[6-(2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 2-cyclopropyl-1-{4-[(2-{[6-(2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclobutyl{4-[(2-{[6-(2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-[(2-{[6-(2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; cyclopropyl{4-[(2-{[6-(2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclobutyl{4-[(2-{[6-(2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl{4-[(2-{[6-(5-fluoro-2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(5-fluoro-2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclobutyl {4-[(2-{[6-(5-fluoro-2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(5-fluoro-2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; tert-butyl 4-[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 3,3,3-trifluoro-1-{4-[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl [{4-[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl {4-[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; 1-4-{[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-2,2-dimethylpropan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[3-(propan-2-yloxy)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{[2-({6-[3-(propan-2-yloxy)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; 2-cyclopropyl-1-(4-{[2-({6-[3-(propan-2-yloxy)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)ethanone; cyclopropyl{4-[(2-{[6-(5-methoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(5-methoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclobutyl{4-[(2-{[6-(5-methoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(5-methoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; 4-{2-[(4-{[4-(cyclopropylcarbonyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1H-benzimidazol-6-yl}-5-methoxy-N,N-dimethylpyridine-2-carboxamide; 1-{4-[(2-{[6-(5-ethoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl{4-[(2-{[6-(5-ethoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(5-ethoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclobutyl {4-[(2-{[6-(5-ethoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl{4-[(2-{[6-(2-methoxy-3-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl(4-{[2-({6-[3-methyl-2-(propan-2-yloxy)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; tert-butyl 4-[(2-{[6-(6-methylpyridin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; cyclopropyl{4-[(2-{[6-(6-methylpyridin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(6-methylpyridin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; tert-butyl 4-[(2-{[6-(6-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; cyclopropyl{4-[(2-{[6-(6-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(6-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclobutyl{4-[(2-{[6-(4-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(4-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl{4-[(2-{[6-(4-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(2-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 2-cyclopropyl-1-{4-[(2-{[6-(2-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl{4-[(2-{[6-(2-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 3,3,3-trifluoro-1-{4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 2-cyclopropyl-1-{4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl {4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl {4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2,2-dimethyl-1-{4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; tert-butyl (2R,5S)-2,5-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 1-{(2R,5S)-2,5-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 2-cyclopropyl-1-{(2R,5S)-2,5-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl{(2R,5S)-2,5-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl{(2R,5S)-2,5-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl (3R)-3-methyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 3,3,3-trifluoro-1-{(3R)-3-methyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 2-cyclopropyl-1-{(3R)-3-methyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl {(3R)-3-methyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl {(3R)-3-methyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 3,3-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 1-{3,3-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 2-cyclopropyl-1-{3,3-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl {3,3-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl {3,3-dimethyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; (rac)-tert-butyl 4-[1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; (rac)-3,3,3-trifluoro-1-{4-[1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; (rac)-cyclopropyl{4-[1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate (single stereoisomer A); 3,3,3-trifluoro-1-{4-[(1R)-1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; 3,3,3-trifluoro-1-{4-[(1S)-1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; cyclopropyl {4-[(1R or 1S)-1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone (single stereoisomer A); tert-butyl 4-[(2-{[6-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 1-{4-[(2-{[6-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 2-cyclopropyl-1-{4-[(2-{[6-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; 1-{4-[(2-{[6-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}but-3-en-1-one; cyclopropyl{4-[(2-{[6-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl{4-[(2-{[6-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; N-(4-{[4-(2-chlorophenyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-amine; 3,3,3-trifluoro-1-(4-{[2-({6-[3-(2-methylpropyl)-1,2,4-oxadiazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{[2-({6-[3-(2-methylpropyl)-1,2,4-oxadiazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; {4-[(2-{[6-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(cyclopropyl)methanone; (4-{[2-({6-[3-(butan-2-yl)-1,2,4-oxadiazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)(cyclopropyl)methanone; {4-[(2-{[6-(3-benzyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(cyclopropyl)methanone; N-(4-{[4-(2-chlorophenyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-1H-benzimidazol-2-amine; N-(4-{[4-(2-chlorophenyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-[5-(2,2-dimethylpropyl)-1,2,4-oxadiazol-3-yl]-1H-benzimidazol-2-amine; 2-cyclopropyl-1-{4-[(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl {4-[(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-methyl-6-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl {4-[(2-methyl-6-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl(4-{[2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}-6-(trifluoromethyl)pyridin-4-yl]methyl}piperazin-1-yl)methanone; (rac)-cyclobutyl{4-[1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; (rac)-cyclopropyl {4-[1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; (rac)-3,3,3-trifluoro-1-{4-[1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; cyclopropyl {4-[(1R)-1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclopropyl {4-[(1S)-1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(1R)-1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; 3,3,3-trifluoro-1-{4-[(1S)-1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; cyclobutyl{4-[(1R)-1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclobutyl{4-[(1S)-1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclobutyl{4-[(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl{4-[(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl{4-[(2-methyl-6-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-methyl-6-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl(4-{[2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}-6-(trifluoromethyl)pyridin-4-yl]methyl}piperazin-1-yl)methanone; (rac)-cyclopropyl{4-[1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; (rac)-cyclobutyl{4-[1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; (rac)-3,3,3-trifluoro-1-{4-[1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; (rac)-2-cyclopropyl-1-{4-[1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}ethanone; 3,3,3-trifluoro-1-{4-[(1R)-1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; 3,3,3-trifluoro-1-{4-[(1S)-1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; cyclobutyl{4-[(1R)-1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclobutyl{4-[(1S)-1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(1R)-1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}ethanone; 2-cyclopropyl-1-{4-[(1S)-1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}ethanone; cyclopropyl{4-[(1R)-1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclopropyl{4-[(1S)-1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; tert-butyl 4-[(2-{[6-(2-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; cyclobutyl{4-[(2-{[6-(2-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(2-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(2-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(2-{[6-(2-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl(4-{[2-{[6-(2-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}-6-(trifluoromethyl)pyridin-4-yl]methyl}piperazin-1-yl)methanone; tert-butyl 4-[(2-{[6-(2-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; cyclopropyl{4-[(2-{[6-(2-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 1-{4-[(2-{[6-(2-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclobutyl{4-[(2-{[6-(2-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(2-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; (rac)-1-{4-[1-(2-{[6-(2-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-{4-[(1R)-1-(2-{[6-(2-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-{4-[(1S)-1-(2-{[6-(2-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{[2-({6-[2-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclobutyl(4-{[2-({6-[2-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; 2-cyclopropyl-1-(4-{[2-({6-[2-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)ethanone; 3,3,3-trifluoro-1-(4-{[2-({6-[2-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; tert-butyl 4-[(2-{[6-(2-ethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; (rac)-3,3,3-trifluoro-1-(4-{1-[2-({6-[6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; (rac)-cyclopropyl(4-{1-[2-({6-[6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 3,3,3-trifluoro-1-(4-{(1R)-1-[2-({6-[6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; 3,3,3-trifluoro-1-(4-{(1S)-1-[2-({6-[6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclobutyl{4-[(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-cyclopropyl-1-{4-[(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl{4-[(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; (rac)-3,3,3-trifluoro-1-{4-[1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; (rac)-cyclobutyl{4-[1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; (rac)-cyclopropyl{4-[1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; (rac)-2-cyclopropyl-1-{4-[1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}ethanone; 3,3,3-trifluoro-1-{4-[(1R)-1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; 3,3,3-trifluoro-1-{4-[(1S)-1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; cyclobutyl{4-[(1R)-1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclobutyl{4-[(1S)-1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclopropyl{4-[(1R)-1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclopropyl{4-[(1S)-1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 1-{4-[(2-{[6-(2,6-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl{4-[(2-{[6-(2,6-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl{4-[(2-{[6-(5,6-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 1-{4-[(2-{[6-(5,6-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-{4-[(2-{[6-(5,6-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; tert-butyl 4-[(2-{[6-(2,5-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 1-{4-[(2-{[6-(2,5-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl {4-[(2-{[6-(2,5-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl{4-[(2-{[6-(2,5-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-[(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; (rac)-3,3,3-trifluoro-1-{4-[1-(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; (rac)-cyclopropyl{4-[1-(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(1R)-1-(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one (single stereoisomer A); 3,3,3-trifluoro-1-{4-[(1S)-1-(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(1R)-1-(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclopropyl{4-[(1S)-1-(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 4-[(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]-N,N-dimethylpiperazine-1-carboxamide; N,N-diethyl-4-[(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxamide; {4-[(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(pyrrolidin-1-yl)methanone; {4-[(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(piperidin-1-yl)methanone; {4-[(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(morpholin-4-yl)methanone; N-(4-{[4-(ethylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-amine; 6-(5-methoxypyrimidin-4-yl)-N-[4-({4-[(3,3,3-trifluoropropyl) sulfonyl]piperazin-1-yl}methyl)pyridin-2-yl]-1H-benzimidazol-2-amine; N-[4-({4-[(3-methoxypropyl)sulfonyl]piperazin-1-yl}methyl)pyridin-2-yl]-6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-amine; N-{4-[(4-{[2-(2-methoxyethoxy)ethyl]sulfonyl}piperazin-1-yl)methyl]pyridin-2-yl}-6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-amine; N-(4-{[4-(cyclopropylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-amine; N-(4-{[4-(cyclohexylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-amine; 6-(5-methoxypyrimidin-4-yl)-N-(4-{[4-(tetrahydro-2H-pyran-4-ylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)-1H-benzimidazol-2-amine; 4-[(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]-N,N-dimethylpiperazine-1-sulfonamide; N-{4-[(4-{[4-(methoxymethyl)piperidin-1-yl]sulfonyl}piperazin-1-yl)methyl]pyridin-2-yl}-6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-amine; N-[4-({4-[(4-methoxypiperidin-1-yl)sulfonyl]piperazin-1-yl}methyl)pyridin-2-yl]-6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-amine; N-[4-({4-[(2,6-dimethylmorpholin-4-yl)sulfonyl]piperazin-1-yl}methyl)pyridin-2-yl]-6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-amine; (rac)-3,3,3-trifluoro-1-{4-[1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; (rac)-2-cyclopropyl-1-{4-[1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}ethanone; (rac)-cyclopropyl{4-[1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; (rac)-cyclobutyl{4-[1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(1R)-1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; 3,3,3-trifluoro-1-{4-[(1S)-1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; 2-cyclopropyl-1-{4-[(1R)-1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}ethanone; 2-cyclopropyl-1-{4-[(1S)-1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}ethanone; cyclopropyl{4-[(1R)-1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclopropyl{4-[(1S)-1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclobutyl{4-[(1R)-1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone); cyclobutyl{4-[(1S)-1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone (single stereoisomer B); tert-butyl 4-{(1R or 1S)-1-[2-({6-[5-(propan-2-yloxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate (single stereoisomer A); 3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[5-(propan-2-yloxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one (single stereoisomer A); cyclopropyl(4-{(1R or 1S)-1-[2-({6-[5-(propan-2-yloxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone (single stereoisomer A); cyclobutyl(4-{(1R or 1S)-1-[2-({6-[5-(propan-2-yloxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone (single stereoisomer A); 3,3,3-trifluoro-1-{4-[(2-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 2-cyclopropyl-1-{4-[(2-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl {4-[(2-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl {4-[(2-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-[(2-{[6-(1-ethyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 1-[{4-[(2-[{[6-(1-ethyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl {4-[(2-{[6-(1-ethyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-{[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; 1-(4-{[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; tert-butyl 4-{(1R or 1S)-1-[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate (single stereoisomer A); 1-(4-{(1R or 1S)-1-[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one (single stereoisomer A); cyclopropyl(4-{(1R or 1S)-1-[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone (single stereoisomer A); 3,3,3-trifluoro-1-{4-[(2-{[6-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 2-cyclopropyl-1-{4-[(2-{[6-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl {4-[(2-{[6-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl {4-[(2-{[6-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-[(2-{[6-(1-methyl-1H-1,2,4-triazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 3,3,3-trifluoro-1-{4-[(2-{[6-(1-methyl-1H-1,2,4-triazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(2-{[6-(1-methyl-1H-1,2,4-triazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-{[2-({6-[1-methyl-3-(2-methylpropyl)-1H-1,2,4-triazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; 3,3,3-trifluoro-1-(4-{[2-({6-[1-methyl-3-(2-methylpropyl)-1H-1,2,4-triazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; cyclopropyl {4-[(2-{[6-(1H-imidazol-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl{4-[(2-{[6-(4-methyl-1H-imidazol-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl{4-[(2-{[6-(4-cyclopropyl-1H-imidazol-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 1-(cyclopropylmethyl)-4-{2-[(4-{[4-(3,3,3-trifluoropropanoyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1H-benzimidazol-6-yl}pyridin-2(1H)-one; 4-[{2-[(4-{[4-(cyclopropylcarbonyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1H-benzimidazol-6-yl}-1-(cyclopropylmethyl)pyridin-2(1H)-one; 4-[{2-[(4-{[4-(cyclobutylcarbonyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1H-benzimidazol-6-yl}-1-(cyclopropylmethyl)pyridin-2(1H)-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(pyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 2-cyclopropyl-1-{4-[(2-{[6-(pyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl {4-[(2-{[6-(pyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 1-{4-[(2-{[6-(2-chloropyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; {4-[(2-{[6-(2-chloropyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(cyclopropyl)methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(2-methylpyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(2-{[6-(2-methylpyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl{4-[(2-{[6-(2-cyclopropylpyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-(4-{[2-({6-[2-(methylsulfanyl)pyrimidin-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 2-cyclopropyl-1-(4-{[2-({6-[2-(methylsulfanyl)pyrimidin-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)ethanone; cyclopropyl(4-{[2-({6-[2-(methylsulfanyl)pyrimidin-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl {4-[(2-{[6-(3-methoxypyridazin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; {4-[(2-{[6-(6-chloro-3-methoxypyridazin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(cyclopropyl)methanone; cyclopropyl{4-[(2-{[6-(6-methoxypyridazin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl{4-[(2-{[6-(5-methoxypyridazin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl{4-[(2-{[6-(6-methoxypyrazin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl{4-[(2-{[6-(2-methoxypyridin-4-yl)-7-(2-methylpropoxy)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(3-methoxypyridin-4-yl)-7-(2-methylpropoxy)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(2-{[6-(3-methoxypyridin-4-yl)-7-(2-methylpropoxy)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl {4-[(2-{[6-(3-methoxypyridin-4-yl)-7-(2-methylpropoxy)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 1-{4-[(2-{[7-ethoxy-6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 2-cyclopropyl-1-{4-[(2-{[7-ethoxy-6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; cyclopropyl {4-[(2-{[7-ethoxy-6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclobutyl{4-[(2-{[7-ethoxy-6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 1-{4-[(2-[{[6-(1-ethyl-1H-pyrazol-4-yl)-7-(2-methylpropoxy)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl{4-[(2-{[6-(1-ethyl-1H-pyrazol-4-yl)-7-(2-methylpropoxy)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 1-{4-[(2-{[7-ethoxy-6-(1-ethyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl{4-[(2-{[7-ethoxy-6-(1-ethyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[7-methyl-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl {4-[(2-{[7-methyl-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1-{[(1R)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1-{[(1S)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; 1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1R)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1S)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl{4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclopropyl {4-[(1R or 1S)-1-(2-{[6-(1-{[(1R)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; cyclopropyl{4-[(1R or 1S)-1-(2-{[6-(1-{[(1S)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS,2RS)-2-methylcyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; 3,3,3-trifluoro-1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS,2RS)-2-methylcyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; cyclobutyl(4-{[2-({6-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; 3,3,3-trifluoro-1-(4-{[2-({6-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{[2-({6-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; tert-butyl 4-{(1R or 1S)-1-[2-({6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate (Single Stereoisomer A); 1-(4-{(1R or 1S)-1-[2-({6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one (Single Stereoisomer A); (4-{(1R or 1S)-1-[2-({6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)(cyclopropyl)methanone (Single Stereoisomer A); 1-(4-{[2-({6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; (4-{[2-({6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)(cyclopropyl)methanone; 1-{4-[(2-{[6-(6-chloro-5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(5-methoxy-6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(2-{[6-(5-methoxy-6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-{[2-({6-[2-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; cyclobutyl(4-{[2-({6-[2-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; 1-(4-{[2-({6-[2-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{[2-({6-[2-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; tert-butyl 4-[(2-{[6-(2-chloro-5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[2-(cyclopropylmethoxy)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; cyclopropyl(4-{[2-({6-[2-(cyclopropylmethoxy)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; 1-(4-{[2-({6-[2-(cyclopropylmethoxy)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; tert-butyl 4-{[2-({6-[6-(cyclopropylmethoxy)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; 1-(4-{[2-({6-[6-(cyclopropylmethoxy)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; tert-butyl 4-[(2-{[6-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; cyclopropyl{4-[(2-{[6-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-dimethylcyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; 1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-dimethylcyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl{4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-dimethylcyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; tert-butyl 4-[(1R or 1S)-1-{2-[(6-{1-[(1-methylcyclopropyl)methyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazine-1-carboxylate; 3,3,3-trifluoro-1-{4-[(1R or 1S)-1-{2-[(6-{1-[(1-methylcyclopropyl)methyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}propan-1-one; tert-butyl 4-[(1R or 1S)-1-{2-[(6-{1-[(1-chlorocyclopropyl)methyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazine-1-carboxylate; 1-{4-[(1R or 1S)-1-{2-[(6-{1-[(1-chlorocyclopropyl)methyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-{4-[(1R or 1S)-1-(2-{[7-chloro-6-(1-{[(1RS)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; {4-[(1R or 1S)-1-(2-{[7-chloro-6-(1-{[(1RS)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}(cyclopropyl)methanone; tert-butyl 4-{(1R or 1S)-1-[2-({6-[1-(cyclopentylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 1-(4-{(1R or 1S)-1-[2-({6-[1-(cyclopentylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; tert-butyl 4-{(1R or 1S)-1-[2-({6-[1-(propan-2-yl)-1H-pyrazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[1-(propan-2-yl)-1H-pyrazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[1-(propan-2-yl)-1H-pyrazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 1-{4-[(1R or 1S)-1-(2-{[6-(1,4-dimethyl-1H-pyrazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; tert-butyl 4-[(1R or 1S)-1-{2-[(6-{1-[(1RS)-1-cyclopropylethyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazine-1-carboxylate; 1-{4-[(1R or 1S)-1-{2-[(6-{1-[(1RS)-1-cyclopropylethyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; tert-butyl 4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 1-(4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; (4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)(cyclopropyl)methanone; 1-{4-[(2-{[6-(6-cyclopropylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl {4-[(2-{[6-(6-cyclopropylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 6-{2-[(4-{[4-(3,3,3-trifluoropropanoyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1H-benzimidazol-6-yl}pyrimidine-4-carbonitrile; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(propan-2-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{[2-({6-[6-(propan-2-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{[2-({6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; (4-{[2-({6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl) [1-(trifluoromethyl)cyclopropyl]methanone; tert-butyl 4-{[2-({6-[6-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; 1-(4-{[2-({6-[6-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{[2-({6-[6-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; tert-butyl 4-({2-[(6-{6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(cyclopropylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(6-chloro-5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(5-methoxy-6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; 3,3,3-trifluoro-1-{4-[(1R or 1S)-1-(2-{[6-(5-methoxy-6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(1R or 1S)-1-(2-{[6-(5-methoxy-6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; {4-[(1R or 1S)-1-(2-{[6-(5-methoxy-6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}[1-(trifluoromethyl)cyclopropyl]methanone; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(6-chloropyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 1-(4-{(1R or 1S)-1-[2-({6-[6-(cyclopropylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-7-fluoro-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; 1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-7-fluoro-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl{4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-7-fluoro-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 1-(4-{(1R or 1S)-1-[2-({6-[1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; tert-butyl 4-{(1R or 1S)-1-[2-({5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethy[}piperazin-1-yl)propan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1,3-dimethyl-1H-pyrazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; 1-{4-[(1R or 1S)-1-(2-{[6-(1,3-dimethyl-1H-pyrazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl{4-[(1R or 1S)-1-(2-{[6-(1,3-dimethyl-1H-pyrazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; tert-butyl 4-({2-[(6-{6-[(3-methoxypropyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; 3,3,3-trifluoro-1-[4-({2-[(6-{6-[(3-methoxypropyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]propan-1-one; tert-butyl 4-[(2-{[6-(6-ethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 1-{4-[(2-{[6-(6-ethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl {4-[(2-{[6-(6-ethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; tert-butyl 4-{[2-({6-[6-(3,5-dimethyl-1,2-oxazol-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; 1-(4-{[2-({6-[6-(3,5-dimethyl-1,2-oxazol-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(morpholin-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(methylsulfanyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{[2-({6-[6-(methylsulfanyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; tert-butyl 4-{[2-({6-[6-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; (rac)-tert-butyl 4-({2-[(6-{6-[1-hydroxyethyl]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; (rac)-3,3,3-trifluoro-1-[4-({2-[(6-{6-[1-hydroxyethyl]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]propan-1-one; 1-{4-[(2-{[6-(6-acetylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; tert-butyl 4-[(1R or 1S)-1-(2-{[7-chloro-6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; 1-{4-[(1R or 1S)-1-(2-{[7-chloro-6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; {4-[(1R or 1S)-1-(2-{[7-chloro-6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}(cyclopropyl)methanone; 1-(4-{(1R or 1S)-1-[2-({7-chloro-6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-(4-{(1R or 1S)-1-[2-({6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carbaldehyde; N-(4-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-amine; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(4-{[4-(3-methylphenyl)piperazin-1-yl]methyl}pyridin-2-yl)-1H-benzimidazol-2-amine; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-{4-[(4-phenylpiperazin-1-yl)methyl]pyridin-2-yl}-1H-benzimidazol-2-amine; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(4-{[4-(pyrimidin-2-yl)piperazin-1-yl]methyl}pyridin-2-yl)-1H-benzimidazol-2-amine; 1-{4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}ethanone; N-(4-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-amine; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-[4-({4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}methyl)pyridin-2-yl]-1H-benzimidazol-2-amine; N-(4-{[4-(3-fluorophenyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-amine; {4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(phenyl)methanone; N-(4-{[4-(2,4-difluorophenyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-amine; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(4-{[4-(pyridin-4-yl)piperazin-1-yl]methyl}pyridin-2-yl)-1H-benzimidazol-2-amine; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]methyl}pyridin-2-yl)-1H-benzimidazol-2-amine; furan-2-yl{4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(4-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}pyridin-2-yl)-1H-benzimidazol-2-amine; 2-hydroxy-2-methyl-1-[{4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; N-(4-{[4-(3-methoxypyridin-2-yl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-amine; 4-[{4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}benzonitrile; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(4-{[4-(6-methylpyridin-2-yl)piperazin-1-yl]methyl}pyridin-2-yl)-1H-benzimidazol-2-amine; 4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxamide; N-(4-{[4-(3,4-difluorophenyl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-amine; 2-{4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}pyridine-3-carbonitrile; N-(4-{[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-amine; {4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(thiophen-2-yl)methanone; {4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(pyridin-3-yl)methanone; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(4-{[4-(1,3,5-triazin-2-yl)piperazin-1-yl]methyl}pyridin-2-yl)-1H-benzimidazol-2-amine; 1-{4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; N-(4-{[4-(6-chloropyrazin-2-yl)piperazin-1-yl]methyl}pyridin-2-yl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-amine; 6-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(4-{[4-(4-methylpyridin-2-yl)piperazin-1-yl]methyl}pyridin-2-yl)-1H-benzimidazol-2-amine; {4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(pyrrolidin-1-yl)methanone; cyclopropyl{4-[(2-{[6-(2,6-dimethylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 4-{2-[(4-{[4-(cyclopropylcarbonyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1H-benzimidazol-6-yl}pyridine-3-carbonitrile; 3,3,3-trifluoro-1-{4-[(2-{[6-(2-methylthieno[2,3-d]pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(thieno[2,3-d]pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[3-(trifluoromethyl)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; tert-butyl 4-{[2-({6-[6-(dimethylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; cyclopropyl(4-{[2-({6-[6-(dimethylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; 1-(4-{[2-({6-[6-(dimethylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(dimethylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(dimethylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 1-(4-{(1R or 1S)-1-[2-({6-[6-(dimethylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; (4-{(1R or 1S)-1-[2-({6-[6-(dimethylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl) [1-(trifluoromethyl)cyclopropyl]methanone; tert-butyl 4-{[2-({6-[6-(cyclopropylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; 1-(4-{[2-({6-[6-(cyclopropylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{[2-({6-[6-(cyclopropylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; tert-butyl 4-({2-[(6-{6-[(cyclopropylmethyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; 1-[4-({2-[(6-{6-[(cyclopropylmethyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]-3,3,3-trifluoropropan-1-one; cyclopropyl[4-({2-[(6-{6-[(cyclopropylmethyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]methanone; tert-butyl 4-[(1R or 1S)-1-{2-[(6-{6-[(cyclopropylmethyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazine-1-carboxylate; cyclopropyl {4-[(1R or 1S)-1-{2-[(6-{6-[(cyclopropylmethyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}methanone; 1-{4-[(1R or 1S)-1-{2-[(6-{6-[(cyclopropylmethyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; tert-butyl 4-({2-[(6-{6-[(cyclopropylmethyl)(methyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; cyclopropyl[4-({2-[(6-{6-[(cyclopropylmethyl)(methyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]methanone; [4-({2-[(6-{6-[(cyclopropylmethyl)(methyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl][1-(trifluoromethyl)cyclopropyl]methanone; 1-[4-({2-[(6-{6-[(cyclopropylmethyl)(methyl)amino]-5-methoxypyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]-3,3,3-trifluoropropan-1-one; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; (4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)(cyclopropyl)methanone; 1-(4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; tert-butyl 4-{(1R or S)-1-[2-({6-[5-methoxy-6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[5-methoxy-6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[5-methoxy-6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin-1-yl)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 1-(4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin-1-yl)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin-1-yl)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(cyclobutylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 1-(4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; (4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)(cyclopropyl)methanone; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 1-(4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; (4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl) [1-(trifluoromethyl)cyclopropyl]methanone; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(morpholin-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(morpholin-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[6-(morpholin-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; (4-{(1R or 1S)-1-[2-({6-[6-(morpholin-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl) [1-(trifluoromethyl)cyclopropyl]methanone; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({6-[1-(cyclopropylmethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 1-(4-{(1R or 1S)-1-[2-({6-[1-(cyclopropylmethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; tert-butyl 4-{(1R or 1S)-1-[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-7-fluoro-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 1-(4-{(1R or 1S)-1-[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-7-fluoro-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-7-fluoro-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; tert-butyl 4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 1-(4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; (4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)(cyclopropyl)methanone; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1-methyl-1H-pyrazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; 3,3,3-trifluoro-1-{4-[(1R or 1S)-1-(2-{[6-(1-methyl-1H-pyrazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; cyclopropyl {4-[(1R or 1S)-1-(2-{[6-(1-methyl-1H-pyrazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(1H-pyrazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; tert-butyl 4-[(5-bromo-2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; 1-{4-[(5-bromo-2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[5-(cyclobutylmethyl)-1,3,4-oxadiazol-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; tert-butyl 4-[(2-{[6-(3-chloro-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(5-fluoro-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(3-chloro-5-fluoropyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(3-cyanopyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[2-(morpholin-4-yl)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[2-(dimethylamino)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2-cyano-6-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2-fluoropyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2-aminopyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[2-(difluoromethyl)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(5-bromopyrazin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-({2-[(6-{6-[(cyclopropylmethyl)(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-({2-[(6-{6-[(cyclopropylmethyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; Tert-butyl 4-[(2-{[6-(6-chloropyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-chloro-5-fluoropyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[5-(dimethylamino)pyrazin-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(piperidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-({2-[(6-{6-[methyl(2,2,2-trifluoroethyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(azetidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-({2-[(6-{6-[ethyl(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(ethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(methylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(cyclopropylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(cyclobutylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-({2-[(6-{6-[methyl(propan-2-yl)amino]pyrimidin-4-yl 1}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(propan-2-ylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(diethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-({2-[(6-{6-[cyclobutyl(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-({2-[(6-{6-[cyclopropyl(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-{[1-(trifluoromethyl)cyclopropyl]methoxy}pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(cyclobutylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(propan-2-yloxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(dimethylamino)-5-fluoropyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; 1-{4-[(2-{[6-(3-chloro-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(5-fluoro-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 1-{4-[(2-{[6-(3-chloro-5-fluoropyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 4-{2-[(4-{[4-(3,3,3-trifluoropropanoyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1H-benzimidazol-6-yl}pyridine-3-carbonitrile; 3,3,3-trifluoro-1-(4-{[2-({6-[2-(morpholin-4-yl)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 1-(4-{[2-({6-[2-(dimethylamino)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 6-methyl-4-{2-[(4-{[4-(3,3,3-trifluoropropanoyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1H-benzimidazol-6-yl}pyridine-2-carbonitrile; 3,3,3-trifluoro-1-{4-[(2-{[6-(2-fluoropyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 1-{4-[(2-{[6-(2-aminopyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[2-(difluoromethyl)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-{4-[(2-{[6-(5-chloropyrazin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-[4-({2-[(6-{6-[(cyclopropylmethyl)(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]-3,3,3-trifluoropropan-1-one; 1-[4-({2-[(6-{6-[(cyclopropylmethyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[5-(dimethylamino)pyrazin-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(piperidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 3,3,3-trifluoro-1-[4-({2-[(6-{6-[methyl(2,2,2-trifluoroethyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]propan-1-one; 1-(4-{[2-({6-[6-(azetidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-[4-({2-[(6-{6-[ethyl(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[6-(ethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(methylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 1-(4-{[2-({6-[6-(cyclopropylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[6-(cyclobutylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-[4-({2-[(6-{6-[methyl(propan-2-yl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]propan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(propan-2-ylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 1-(4-{[2-({6-[6-(diethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-[4-({2-[(6-{6-[cyclobutyl(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]-3,3,3-trifluoropropan-1-one; 1-[4-({2-[(6-{6-[cyclopropyl(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(6-{[1-(trifluoromethyl)cyclopropyl]methoxy}pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 1-(4-{[2-({6-[6-(cyclobutylmethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(propan-2-yloxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 1-{4-[(2-{[6-(6-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[6-(dimethylamino)-5-fluoropyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; {4-[(2-{[6-(3-chloro-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(cyclopropyl)methanone; cyclopropyl{4-[(2-{[6-(5-fluoro-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; {4-[(2-{[6-(3-chloro-5-fluoropyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(cyclopropyl)methanone; cyclopropyl(4-{[2-({6-[2-(morpholin-4-yl)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl(4-{[2-({6-[2-(dimethylamino)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; 4-{2-[(4-{[4-(cyclopropylcarbonyl)piperazin-1-yl]methyl}pyridin-2-yl)amino]-1H-benzimidazol-6-yl}-6-methylpyridine-2-carbonitrile; cyclopropyl {4-[(2-{[6-(2-fluoropyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; {4-[(2-{[6-(2-aminopyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(cyclopropyl)methanone; cyclopropyl(4-{[2-({6-[2-(difluoromethyl)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; {4-[(2-{[6-(5-chloropyrazin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(cyclopropyl)methanone; cyclopropyl[4-({2-[(6-{6-[(cyclopropylmethyl)(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]methanone; cyclopropyl[4-({2-[(6-{6-[(cyclopropylmethyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]methanone; cyclopropyl(4-{[2-({6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl(4-{[2-({6-[5-(dimethylamino)pyrazin-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl(4-{[2-({6-[6-(piperidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl[4-({2-[(6-{6-[ethyl(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]methanone; cyclopropyl(4-{[2-({6-[6-(ethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl(4-{[2-({6-[6-(methylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl(4-{[2-({6-[6-(cyclopropylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; (4-{[2-({6-[6-(cyclobutylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)(cyclopropyl)methanone; cyclopropyl[4-({2-[(6-{6-[methyl(propan-2-yl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]methanone; cyclopropyl(4-{[2-({6-[6-(propan-2-ylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl(4-{[2-({6-[6-(diethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; [4-({2-[(6-{6-[cyclobutyl(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl](cyclopropyl)methanone; cyclopropyl[4-({2-[(6-{6-[cyclopropyl(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]methanone; cyclopropyl{4-[(2-{[6-(6-{[1-(trifluoromethyl)cyclopropyl]methoxy}pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl(4-{[2-({6-[6-(propan-2-yloxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl {4-[(2-{[6-(6-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl {4-[(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; {4-[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}[1-(trifluoromethyl)cyclopropyl]methanone; ((1RS)-2,2-difluorocyclopropyl) {4-[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 2-hydroxy-1-{4-[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-2-methylpropan-1-one; 2-methoxy-1-{4-[(2-{[6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-2-methylpropan-1-one; {4-[(1R or 1S)-1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}[1-(trifluoromethyl)cyclopropyl]methanone; ((1RS)-2,2-difluorocyclopropyl) {4-[(1R or 1S)-1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; 2-hydroxy-2-methyl-1-{4-[(1R or 1S)-1-(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; (4-{(1R or 1S)-1-[2-({6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl) [1-(trifluoromethyl)cyclopropyl]methanone; 1-(4-{(1R or 1S)-1-[2-({6-[6-(cyclobutylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; (4-{(1R or 1S)-1-[2-({6-[6-(cyclobutylamino)-5-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)(cyclopropyl)methanone; (4-{(1R or 1S)-1-[2-({6-[6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl) [1-(trifluoromethyl)cyclopropyl]methanone; ((1RS)-2,2-difluorocyclopropyl)(4-{(1R or 1S)-1-[2-({6-[6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; [(1RS)-2,2-difluoro-1-methylcyclopropyl](4-{(1R or S)-1-[2-({6-[6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 2-hydroxy-2-methyl-1-(4-{(1R or 1S)-1-[2-({6-[6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; 3,3,3-trifluoro-1-(4-{(1R)-1-[2-({6-[6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; (4-{(1R or 1S)-1-[2-({6-[6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl) [1-(trifluoromethyl)cyclopropyl]methanone; ((1RS)-2,2-difluorocyclopropyl)(4-{(1R or 1S)-1-[2-({6-[6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; tert-butyl 4-[(1R or 1S)-1-{2-[(6-{6-[3-(trifluoromethyl)azetidin-1-yl]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(2,2-difluoropropoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(2,2,3,3,3-pentafluoropropoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-ethoxy-5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(furo[3,2-d]pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-{2-[(6-{1-[(3,3-difluorocyclobutyl)methyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-dichlorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-7-fluoro-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-(2-{[7-fluoro-6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({7-fluoro-6-[6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; 3,3,3-trifluoro-1-{4-[(1R or 1S)-1-{2-[(6-{6-[3-(trifluoromethyl)azetidin-1-yl]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}propan-1-one; cyclopropyl {4-[(1R or 1S)-1-{2-[(6-{6-[3-(trifluoromethyl)azetidin-1-yl]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}methanone; {4-[(1R or 1S)-1-{2-[(6-{6-[3-(trifluoromethyl)azetidin-1-yl]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}[1-(trifluoromethyl)cyclopropyl]methanone; ((1RS)-2,2-difluorocyclopropyl) {4-[(1R or 1S)-1-{2-[(6-{6-[3-(trifluoromethyl)azetidin-1-yl]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}methanone; 1-(4-{(1R or 1S)-1-[2-({6-[6-(2,2-difluoropropoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(2,2-difluoropropoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[6-(2,2,3,3,3-pentafluoropropoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(2,2,3,3,3-pentafluoropropoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; (4-{(1R or 1S)-1-[2-({6-[6-(2,2,3,3,3-pentafluoropropoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)[1-(trifluoromethyl)cyclopropyl]methanone; ((1RS)-2,2-difluorocyclopropyl)(4-{(1R or 1S)-1-[2-({6-[6-(2,2,3,3,3-pentafluoropropoxy)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; 1-{4-[(2-{[6-(6-ethoxy-5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl{4-[(2-{[6-(6-ethoxy-5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; {4-[(2-{[6-(6-ethoxy-5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}[1-(trifluoromethyl)cyclopropyl]methanone; 3,3,3-trifluoro-1-{4-[(2-{[6-(furo[3,2-d]pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(2-{[6-(furo[3,2-d]pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; 1-{4-[(1R or 1S)-1-{2-[(6-{1-[(3,3-difluorocyclobutyl)methyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; cyclopropyl {4-[(1R or 1S)-1-{2-[(6-{1-[(3,3-difluorocyclobutyl)methyl]-1H-pyrazol-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}methanone; 1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-dichlorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 1-(4-{(1R or 1S)-1-[2-({6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-7-fluoro-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; (4-{(1R or 1S)-1-[2-({6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-7-fluoro-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)(cyclopropyl)methanone; 3,3,3-trifluoro-1-{4-[(1R or 1S)-1-(2-{[7-fluoro-6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}propan-1-one; cyclopropyl{4-[(1R or 1S)-1-(2-{[7-fluoro-6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}methanone; {4-[(1R or 1S)-1-(2-{[7-fluoro-6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazin-1-yl}[1-(trifluoromethyl)cyclopropyl]methanone; 3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({7-fluoro-6-[6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({7-fluoro-6-[6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; (4-{(1R or 1S)-1-[2-({7-fluoro-6-[6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl) [1-(trifluoromethyl)cyclopropyl]methanone; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(difluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2-chlorothiophen-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(morpholin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[2-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[2-(dimethylamino)-6-methylpyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[5-chloro-6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(pyrimidin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[4-(dimethylamino)pyrimidin-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(5,7-dihydrofuro[3,4-d]pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[5-methyl-6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(5-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-chloro-2-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-chloro-2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-chloro-5-fluoropyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(3-chloropyrazin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(dimethylamino)-2-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(dimethylamino)-2-methylpyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-({2-[(6-{6-[(cyclobutylmethyl)amino]-5-fluoropyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(cyclopropylamino)-5-fluoropyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[5-fluoro-6-(propan-2-ylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(cyclobutylamino)-5-fluoropyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-({2-[(6-{6-[(cyclopropylmethyl)amino]-5-fluoropyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[3-(dimethylamino)pyrazin-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-{2-[(6-{6-[(cyclopropylmethyl)(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(3,6-dihydro-2H-pyran-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; 1-(4-{(1R or 1S)-1-[2-({6-[6-(difluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-{4-[(2-{[6-(2-chlorothiophen-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(6-methoxy-2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[2-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 1-(4-{[2-({6-[2-(dimethylamino)-6-methylpyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[5-chloro-6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(pyrimidin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 1-(4-{[2-({6-[4-(dimethylamino)pyrimidin-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-{4-[(2-{[6-(5,7-dihydrofuro[3,4-d]pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[5-methyl-6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 3,3,3-trifluoro-1-{4-[(2-{[6-(5-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}propan-1-one; 1-(4-{[2-({6-[6-(dimethylamino)-2-methoxypyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[6-(dimethylamino)-2-methylpyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-[4-({2-[(6-{6-[(cyclobutylmethyl)amino]-5-fluoropyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[6-(cyclopropylamino)-5-fluoropyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[5-fluoro-6-(propan-2-ylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; 1-(4-{[2-({6-[6-(cyclobutylamino)-5-fluoropyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 1-[4-({2-[(6-{6-[(cyclopropylmethyl)amino]-5-fluoropyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]-3,3,3-trifluoropropan-1-one; 1-(4-{[2-({6-[3-(dimethylamino)pyrazin-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one; 3,3,3-trifluoro-1-(4-{[2-({6-[6-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)propan-1-one; cyclopropyl(4-{(1R or 1S)-1-[2-({6-[6-(difluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)methanone; {4-[(2-{[6-(2-chlorothiophen-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}(cyclopropyl)methanone; (4-{[2-([{6-[5-chloro-6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)(cyclopropyl)methanone; cyclopropyl {4-[(2-{[6-(pyrimidin-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl(4-{[2-({6-[4-(dimethylamino)pyrimidin-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl{4-[(2-{[6-(5,7-dihydrofuro[3,4-d]pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; cyclopropyl(4-{[2-({6-[5-methyl-6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl {4-[(2-{[6-(5-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazin-1-yl}methanone; [4-({2-[(6-{6-[(cyclobutylmethyl)amino]-5-fluoropyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl](cyclopropyl)methanone; cyclopropyl(4-{[2-({6-[6-(cyclopropylamino)-5-fluoropyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; cyclopropyl(4-{[2-({6-[5-fluoro-6-(propan-2-ylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; (4-{[2-([{6-[6-(cyclobutylamino)-5-fluoropyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)(cyclopropyl)methanone; cyclopropyl[4-({2-[(6-{6-[(cyclopropylmethyl)amino]-5-fluoropyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}methyl)piperazin-1-yl]methanone; cyclopropyl(4-{[2-({6-[3-(dimethylamino)pyrazin-2-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazin-1-yl)methanone; {4-[(1R or 1S)-1-{2-[(6-{6-[(cyclopropylmethyl)(methyl)amino]pyrimidin-4-yl}-1H-benzimidazol-2-yl)amino]pyridin-4-yl}ethyl]piperazin-1-yl}[1-(trifluoromethyl)cyclopropyl]methanone; tert-butyl 4-[(2-{[6-(5-fluoro-2-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[3-(2,2,2-trifluoroethoxy)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[3-(propan-2-yloxy)pyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(5-methoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(5-ethoxy-2-methylpyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(4-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2-methoxypyridin-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl (3R)-3-methyl-4-[(2-{[6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[3-(2-methylpropyl)-1,2,4-oxadiazol-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-methyl-6-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; (rac)-tert-butyl 4-[1-(2-{[6-(pyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-methyl-6-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; (rac)-tert-butyl 4-[1-(2-{[6-(2-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; (rac)-tert-butyl 4-[-1-(2-{[6-(2-ethoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[2-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; (rac)-tert-butyl 4-{1-[2-({6-[6-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; (rac)-tert-butyl 4-[1-(2-{[6-(6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2,6-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(5,6-dimethylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; (rac)-tert-butyl 4-[1-(2-{[6-(6-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; (rac)-tert-butyl 4-[1-(2-{[6-(5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[1-(cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(pyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2-chloropyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2-methylpyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(2-cyclopropylpyrimidin-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[2-(methylsulfanyl)pyrimidin-5-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(3-methoxypyridin-4-yl)-7-(2-methylpropoxy)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[7-ethoxy-6-(3-methoxypyridin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(1-ethyl-1H-pyrazol-4-yl)-7-(2-methylpropoxy)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[7-ethoxy-6-(1-ethyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[7-methyl-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate, tert-butyl 4-{[2-({6-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-chloro-5-methoxypyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(5-methoxy-6-methylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate, and tert-butyl 4-[(2-{[6-(2-chloropyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-(2-{[7-chloro-6-(1-{[(1RS)-2,2-difluorocyclopropyl]methyl}-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-[(1R or 1S)-1-(2-{[6-(1,4-dimethyl-1H-pyrazol-5-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)ethyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-cyclopropylpyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-cyanopyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(propan-2-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-[(2-{[6-(6-chloropyrimidin-4-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({6-[1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(pyrrolidin-1-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(morpholin-4-yl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{[2-({6-[6-(methylsulfanyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({7-chloro-6-[6-(methoxymethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; tert-butyl 4-{(1R or 1S)-1-[2-({6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazine-1-carboxylate; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 94.0
- Lexical Diversity: 1.61404
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15080068', '14772865', '14403151', '13078192', '15083503']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8208108355473778
- 35 USC 102 Novelty (BERT): 0.5150906715594983
- Combined Prediction Score: 0.7902388191485898
- Mean Citation Score: 306.67584
- Max Citation Score: 309.4958200000001
- Similarity Product: 234.991264030322

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test