PATENT CLAIM ANALYSIS

Application Number: 16319951
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-07
Patent Classification: ["544", "277000"]

Abstract:
There are provided substituted purine and 3-deazapurine analogues, which modulate the activity of Choline Kinase (ChoK). The compounds of this invention are therefore useful in treating diseases caused by an altered choline metabolism, such as cancer, cell proliferative disorders, infectious diseases of different origin, immune-related disorders and neurodegenerative disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

Claim (Index 2):
A compound or pharmaceutically acceptable salt according to  claim 1 , wherein:\n X is CH or nitrogen; A is a 6- or 7-membered cycloalkyl or a 6- or 7-membered nitrogen-containing heterocyclyl, or A is a 7- to 9-membered carbon bicyclic system, in which one ring carbon is optionally replaced by a nitrogen; R1 is linked: either 1) to any A ring carbon, in which case R1 is fluorine, \u2014COOR4, \u2014CONR4R5, \u2014NR4COOR6, \u2014NR4COR5, \u2014NR4R5, \u2014NR4CONR4R5, \u2014NR4CSNR4R5, or \u2014NR4SO 2 R6; or 2) to the A ring nitrogen, if present, in which case R1 is \u2014COR5, \u2014COOR6, \u2014CONR4R5, \u2014CSNR4R5, or \u2014SO 2 R6;\n wherein: \n R4 and R5 are independently hydrogen or an optionally substituted group selected from (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, heterocyclyl, aryl, aryl(C 1 -C 6 )alkyl, heteroaryl and heteroaryl(C 1 -C 6 )alkyl; or R4 and R5, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted 5- or 6-membered heterocyclyl group optionally containing one additional heteroatom selected from N, O and S; \n R6 is an optionally substituted group selected from (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, heterocyclyl, aryl, aryl(C 1 -C 6 )alkyl, heteroaryl and heteroaryl(C 1 -C 6 )alkyl; \n n is 0, 1 or 2; R2 is linked to any A ring atom and is selected from the group consisting of fluorine, an optionally substituted (C 1 -C 6 )alkyl and NR4R5; provided that\n when R2 is fluorine or NR4R5, then R2 is linked to a ring carbon; \n when n is 2, then the R2 groups are not necessarily the same; \n wherein the R1 and R2 groups can be linked to the same ring carbon; R3 is hydrogen, halogen, cyano or an optionally substituted group selected from polyfluorinated (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 2 -C 6 )alkynyl, heterocyclyl, aryl, heteroaryl, \u2014OR6 or \u2014CONR4R5, wherein R4, R5 and R6 are as defined above; when X is nitrogen, then R3 is different from hydrogen.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 99.0
- Lexical Diversity: 1.52632
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12678806', '13377854', '14874513', '15335619', '13780557']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8163934061113725
- 35 USC 102 Novelty (BERT): 0.5018953144282257
- Combined Prediction Score: 0.7849435969430578
- Mean Citation Score: 270.152288
- Max Citation Score: 281.84406
- Similarity Product: 211.6714371252501

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test