PATENT CLAIM ANALYSIS

Application Number: 16131287
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-07
Patent Classification: ["514", "259000"]

Abstract:
The invention provides substituted imidazo[1,5-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidine compounds described herein include substituted 2,4-dimethyl-N-phenylimidazo[1,5-a]pyrimidine-8-carboxamide compounds and variants thereof.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1  represents independently for each occurrence hydrogen, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxyl, \u2014(C 1-4  alkylene)-(C 1-4  alkoxyl), cyclopropyl, cyano, chloro, or fluoro; R 2  is hydrogen, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxyl, cyclopropyl, cyano, chloro, or fluoro; R 3  represents independently for each occurrence hydrogen or C 1-4  alkyl; R 4  represents independently for each occurrence hydrogen, C 1-4  alkyl, or \u2014C(O)R 3 ; X 1  is one of the following:\n (a) a carbonyl-containing linker selected from \u2014C(O)N(H)-\u03c8, \u2014C(O)N(H)(C 1-6  alkylene)-\u03c8, and \u2014C(O)-(3-6 membered heterocycloalkylene containing at least one ring \u2014N(H)\u2014 group)-\u03c8; where \u03c8 is a bond to A 1 ; or \n (b) an amine-containing linker selected from \u2014(C 1-4  alkylene)-N(H)-\u03c8 and \u2014(C 1-4  alkylene)-N(H)\u2014(C 1-4  alkylene)-\u03c8; \n A 1  is a cyclic group selected from:\n C 3-10  cycloalkyl, phenyl, or 5-6 membered heteroaryl, each of which is substituted by 1 or 2 occurrences of Y 1  and 0, 1, 2, or 3 occurrences of Y 2 ; and \n a bicyclic carbocyclyl that is partially unsaturated or a mono-cyclic or bicyclic heterocyclyl, each of which is substituted by 0, 1, or 2 occurrences of Y 1  and 0, 1, 2, or 3 occurrences of Y 2 ; \n Y 1  represents, independently for each occurrence, one of the following:\n 2-8 membered heteroalkyl optionally substituted by a 6-10 membered aryl or a 3-10 membered heterocyclyl; \n 3-10 membered heterocyclyl, 6-10 membered aryl, C 3-7  cycloalkyl, \u2014O\u2014C 3-7  cycloalkyl, \u2014O-(3-6 membered heterocyclyl), \u2014O-(6-10 membered aryl), or \u2014O\u2014(C 2-6  alkynyl); \n C 2-6  alkynyl, \u2014C\u2261C\u2014(C 1-6  alkylene)-OR 4 , \u2014C\u2261C\u2014(C 1-6  alkylene)-N(R 3 ) 2 , \u2014(C 2-4  alkynylene)-(5-6 membered heteroaryl), or C 2-6  alkenyl; or \n halogen or cyano; \n Y 2  represents, independently for each occurrence, deuterium, C 1-6  alkyl, C 3-6  cycloalkyl, halogen, C 1-6  haloalkyl, C 1-6  hydroxyalkyl, hydroxyl, C 1-6  alkoxyl, cyano, azido, \u2014N(R 3 ) 2 , \u2014(C 1-6  alkylene)-(5-6 membered heterocyclyl), \u2014(C 1-6  alkylene)-CO 2 R 3 , or C 1-6  haloalkyl-substituted C 3-6  cycloalkyl; and n is 1, 2, or 3.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 97.0
- Lexical Diversity: 1.62
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15678474', '15523769', '15440107', '15678468', '15551132']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7942505323006175
- 35 USC 102 Novelty (BERT): 0.545776970769521
- Combined Prediction Score: 0.7694031761475079
- Mean Citation Score: 342.03664200000014
- Max Citation Score: 373.82022
- Similarity Product: 347.95897628554343

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test