PATENT CLAIM ANALYSIS

Application Number: 16260387
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["205", "775000"]

Abstract:
A method of detecting a state of a lipid membrane in a cell of a nanopore based sequencing chip is disclosed. A lipid membrane is coupled with an integrating capacitor, wherein the lipid membrane is between a working electrode and a counter electrode. An alternating current (AC) voltage is applied to the counter electrode. A voltage across the integrating capacitor is periodically sampled by an analog-to-digital converter (ADC). A change in the sampled voltage across the integrating capacitor in response to an intermediate change in the AC voltage is determined. A state of the lipid membrane is determined based on the determined change in the sampled voltage across the integrating capacitor in response to the intermediate change in the AC voltage.

Claim (Index 17):
The system of  claim 15 , wherein the cell is one of a plurality of cells in a nanopore-based sequencing chip, further comprising:\n a constant pre-charging voltage source; to wherein the processor or circuitry is further configured to: pre-charge the integrating capacitor by connecting the integrating capacitor to the constant pre-charging voltage source using a global pre-charge signal, wherein the global pre-charge signal is used to control a timing of the pre-charging of integrating capacitors in the plurality of cells; after the integrating capacitor is charged to the constant pre-charging voltage source value, disconnect the pre-charging voltage source from the integrating capacitor using the global pre-charge signal, wherein the global pre-charge signal is used to control a timing of the disconnecting of the pre-charging voltage source from integrating capacitors in the plurality of cells; wait a predetermined period of time for the integrating capacitor to charge or discharge through a capacitance associated with the lipid bilayer; and cause the analogy measurement circuitry to sample the voltage across the integrating capacitor after the predetermined waiting period.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 99.0
- Lexical Diversity: 2.58824
- Patent Class: 205.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15715669', '15085700', '16186894', '15630342', '15085713']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7089997645797549
- 35 USC 102 Novelty (BERT): 0.6118154807623779
- Combined Prediction Score: 0.6992813361980171
- Mean Citation Score: 347.888724
- Max Citation Score: 547.5157
- Similarity Product: 500.8805402669728

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test