PATENT CLAIM ANALYSIS

Application Number: 15756806
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["435", "006140"]

Abstract:
The present application relates to detection of changes in the number of nucleotides in short homopolymeric nucleic acid repeats, in particular in short homopolymeric microsatellites, for example for the purpose of diagnosing microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency in tumors. Accordingly, methods are provided for detecting changes in the number of nucleotides present in short homopolymeric nucleotide repeat sequences as well as kits and cartridges for automated detection of said changes.

Claim (Index 1):
A method for detecting changes in the number of nucleotides present in a homopolymeric nucleotide repeat sequence equal to or shorter than 15 bp in length, the method comprising the steps of:\n a) generating amplicons by amplifying a nucleic acid sequence comprising the target homopolymeric repeat sequence; b) heating the generated amplicons in the presence of at least one signal-generating oligonucleotide probe comprising a sequence capable of hybridizing to the target homopolymeric repeat sequence, and detecting the changes in the strength of the signal generated by said probe in the function of temperature to obtain at least one melting curve; and c) deducing the number of nucleotides present in the target homopolymeric repeat sequence from the at least one melting curve;

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.60784
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13860422', '11487156', '14506565', '11576597', '12109775']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5965363901716048
- 35 USC 102 Novelty (BERT): 0.5098868094180882
- Combined Prediction Score: 0.5878714320962531
- Mean Citation Score: 255.72762200000005
- Max Citation Score: 278.07953
- Similarity Product: 177.3142335435152

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test