PATENT CLAIM ANALYSIS

Application Number: 16219589
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["514", "210180"]

Abstract:
The subject matter generally relates to methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) as neuroprotective agents and/or neural regenerative agents. In a further aspect, the subject matter relates to individuals that are at risk for the development of CNS disease or disorder.

Claim (Index 9):
A method of  claim 1 , wherein the PDE1 inhibitor is compound of Formula VIII: wherein\n (i) R 1  is H or C 1-6 alkyl; \n (ii) R 2  is\n H, \n C 1-6 alkyl, \n C 3-8 cycloalkyl optionally substituted with one or more amino, \n C 3-8 heterocycloalkyl optionally substituted with C 1-6 alkyl, \n C 3-8 cycloalkyl-C 1-6 -alkyl, \n C 1-6 haloalkyl, \n C 0-6 alkylaminoC 0-6 alkyl, \n hydroxyC 1-6 alkyl, \n arylC 0-6 alkyl, \n heteroarylalkyl, \n C 1-6 -alkoxyarylC 1-6 alkyl, or \n G-J wherein:\n G is a single bond or, alkylene; \n J is cycloalkyl or heterocycloalkyl optionally substituted with alkyl; \n \n \n (iii) R 3  is\n a) -D-E-F wherein\n 1. D is single bond, C 1-6 alkylene or arylC 1-6 alkylene;\n 2. E is a C 1-6 alkylene, arylene, C 1-6 alkylarylene, aminoC 1-6 alkylene- or amino; and \n 3. F is heteroC 3-8 cycloalkyl optionally substituted with C 1 -6alkyl; \n \n \n \n (iv) R 4  is aryl optionally substituted with one or more halo, hydroxy or C 1-6 alkoxy; heteroaryl or heteroC 3-6 cycloalkyl; and \n (v) R 5  is H, C 1-6 alkyl, C 3-8 cycloalkyl, heteroaryl, aryl or p-benzylaryl; \n wherein \u201calk\u201d, \u201calkyl\u201d, \u201chaloalkyl\u201d or \u201calkoxy\u201d refers to C 1-6  alkyl and \u201ccycloalkyl\u201d refers to C 3-8 cycloalkyl; in free or salt form.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 98.0
- Lexical Diversity: 1.54545
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14777448', '15406346', '14767489', '15709258', '14820323']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7813365409224772
- 35 USC 102 Novelty (BERT): 0.5577491148793503
- Combined Prediction Score: 0.7589777983181645
- Mean Citation Score: 348.187806
- Max Citation Score: 492.94012
- Similarity Product: 403.1781050383997

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test