PATENT CLAIM ANALYSIS

Application Number: 15778168
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["514", "259310"]

Abstract:
The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X 1  represents —NH═ or —CH═, X 2  represents —CH═ or —N═, R 1  and R 2  each represent a C 1  to C 6  alkoxy group or the like, R 3  represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R 4  represents a C 1  to C 6  alkylthio group or a C 2  to C 6  alkenyl group (the C 1  to C 6  alkylthio group and the C 2  to C 6  alkenyl group are each optionally substituted by one carboxy group or the like) or the like.

Claim (Index 1):
A compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein X 1  represents \u2014N\u2550 or \u2014CH\u2550, X 2  represents \u2014CH\u2550 or \u2014N\u2550, R 1  and R 2  each independently represent a C 1  to C 6  alkyl group, a C 1  to C 6  alkoxy group, or a halogeno group (the C 1  to C 6  alkyl group and the C 1  to C 6  alkoxy group are each optionally substituted by 1 to 3 fluoro groups), R 3  represents an aryl group, a heteroaryl group, a C 1  to C 6  alkyl group, or a C 3  to C 8  cycloalkyl group (the aryl group and the heteroaryl group are each optionally substituted by 1 to 3 identical or different groups selected from a C 1  to C 6  alkyl group, a C 1  to C 6  alkoxy group, a trifluoromethyl group, and a halogeno group), and R 4  represents a C 1  to C 6  alkylthio group, an aryl-C 1  to C 6  alkylthio group, a heteroaryl-C 1  to C 6  alkylthio group, a C 3  to C 8  cycloalkyl-C 1  to C 6  alkylthio group, a heterocycloalkyl-C 1  to C 6  alkylthio group, a C 2  to C 6  alkenyl group, an aryl-C 2  to C 6  alkenyl group, a heteroaryl-C 2  to C 6  alkenyl group, a C 3  to C 8  cycloalkyl-C 2  to C 6  alkenyl group, a heterocycloalkyl-C 2  to C 6  alkenyl group, a C 2  to C 6  alkynyl group, an aryl-C 2  to C 6  alkynyl group, a heteroaryl-C 2  to C 6  alkynyl group, a C 3  to C 8  cycloalkyl-C 2  to C 6  alkynyl group, a heterocycloalkyl-C 2  to C 6  alkynyl group, a C 1  to C 6  alkyl group, an aryl-C 1  to C 6  alkyl group, a heteroaryl-C 1  to C 6  alkyl group, a C 3  to C 8  cycloalkyl-C 1  to C 6  alkyl group, a heterocycloalkyl-C 1  to C 6  alkyl group, a C 1  to C 6  alkoxy group, an aryl-C 1  to C 6  alkoxy group, a heteroaryl-C 1  to C 6  alkoxy group, a C 3  to C 8  cycloalkyl-C 1  to C 6  alkoxy group, a heterocycloalkyl-C 1  to C 6  alkoxy group, an aryl group, a heteroaryl group, a heterocycloalkyl group, a thiol group, a methylsulfonyl group, a halogeno group, or a hydrogen (the C 1  to C 6  alkylthio group, the aryl-C 1  to C 6  alkylthio group, the heteroaryl-C 1  to C 6  alkylthio group, the C 3  to C 8  cycloalkyl-C 1  to C 6  alkylthio group, the heterocycloalkyl-C 1  to C 6  alkylthio group, the C 2  to C 6  alkenyl group, the aryl-C 2  to C 6  alkenyl group, the heteroaryl-C 2  to C 6  alkenyl group, the C 3  to C 8  cycloalkyl-C 2  to C 6  alkenyl group, the heterocycloalkyl-C 2  to C 6  alkenyl group, the C 2  to C 6  alkynyl group, the aryl-C 2  to C 6  alkynyl group, the heteroaryl-C 2  to C 6  alkynyl group, the C 3  to C 8  cycloalkyl-C 2  to C 6  alkynyl group, the heterocycloalkyl-C 2  to C 6  alkynyl group, the C 1  to C 6  alkyl group, the aryl-C 1  to C 6  alkyl group, the heteroaryl-C 1  to C 6  alkyl group, the C 3  to C 8  cycloalkyl-C 1  to C 6  alkyl group, the heterocycloalkyl-C 1  to C 6  alkyl group, the C 1  to C 6  alkoxy group, the aryl-C 1  to C 6  alkoxy group, the heteroaryl-C 1  to C 6  alkoxy group, the C 3  to C 8  cycloalkyl-C 1  to C 6  alkoxy group, the heterocycloalkyl-C 1  to C 6  alkoxy group, the aryl group, the heteroaryl group, and the heterocycloalkyl group are each optionally substituted by one group, and the heteroaryl-C 1  to C 6  alkylthio group, the heteroaryl-C 2  to C 6  alkenyl group, the heteroaryl-C 2  to C 6  alkynyl group, the heteroaryl-C 1  to C 6  alkyl group, the heteroaryl-C 1  to C 6  alkoxy group, and the heteroaryl group are each optionally substituted at the heteroaryl group moiety by 1 to 4 identical or different groups selected from an oxo group, a C 1  to C 6  alkyl group, and a halogeno group).

Metadata:
- Claim Count in Document: 43.0
- Percentile: 93.0
- Lexical Diversity: 2.40845
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['10718337', '13995300', '10344157', '14322505', '12397132']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8183905622482613
- 35 USC 102 Novelty (BERT): 0.5377889151135817
- Combined Prediction Score: 0.7903303975347934
- Mean Citation Score: 366.950764
- Max Citation Score: 379.27014
- Similarity Product: 327.60615059712416

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test