PATENT CLAIM ANALYSIS

Application Number: 16175758
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["800", "021000"]

Abstract:
A genetically modified mouse is provided that comprises a conditional Acvr1 allele that comprises a mutated exon that, upon induction, converts to a mutant exon phenotype, wherein the mutant exon phenotype includes ectopic bone formation. Mice comprising a mutant Acvr1 exon 5 in antisense orientation, flanked by site-specific recombinase recognition sites, are provided, wherein the mice further comprise a site-specific recombinase that recognizes the site-specific recombinase recognitions sites, wherein the recombinase is induced upon exposure of the mouse to tamoxifen. Upon exposure to tamoxifen, the recombinase is expressed and acts on the RRS-flanked mutant exon 5 and places the mutant exon 5 in sense orientation and deletes the wild-type exon.

Claim (Index 17):
The method according to  claim 10 , further comprising inducing the Cre recombinase in the progeny mouse, wherein the recombinase inverts the mouse Acvr1 gene exon 5 into sense orientation and deletes the human Acvr1 gene exon 5, thereby producing the recombined modified mouse Acvr1 gene encoding the R206H variation, and allowing the recombined modified mouse Acvr1 gene to be expressed resulting in ectopic bone formation.

Metadata:
- Claim Count in Document: 75.0
- Percentile: 97.0
- Lexical Diversity: 2.01667
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14207320', '15983743', '16175762', '15336603', '09853033']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8370112534584984
- 35 USC 102 Novelty (BERT): 0.7207540175363877
- Combined Prediction Score: 0.8253855298662873
- Mean Citation Score: 955.718586
- Max Citation Score: 1115.7084
- Similarity Product: 813.7175494674683

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test