PATENT CLAIM ANALYSIS

Application Number: 15896867
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "303000"]

Abstract:
Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Claim (Index 31):
The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is selected from C 2-6  alkynyl, CN, NO 2 , OR a , SR a , C(O)R b , C(O)NR c R d , C(O)OR a , OC(O)R b , OC(O)NR c R d , NR j R k , NR c C(O)R b , NR c C(O)OR a , NR c C(O)NR c R d , C(\u2550NR e )R b , C(\u2550NOR a )R b , C(\u2550NR e )NR c R d , NR c C(\u2550NR e )NR c R d , NR c S(O)R b , NR c S(O) 2 R b , NR c S(O) 2 NR c R d , S(O)R b , S(O) 2 R b , S(O)NR c R d , and S(O) 2 NR c R d ; wherein said C 2-6  alkynyl is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 10 ; Cy A  is 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl comprises one or more ring-forming carbon atoms and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; wherein the N and S are optionally oxidized; wherein a carbon atom of 5-10 membered heteroaryl is optionally substituted by oxo to form a carbonyl group; and wherein the 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 20 ; or Cy A  is phenyl a fused with a 5-6 membered heterocycloalkyl ring; wherein the fused 5-6 membered heterocycloalkyl ring comprises ring-forming carbon atoms and 1 or 2 ring-forming heteroatoms independently selected from N, O, and S, wherein the N and S are optionally oxidized; wherein a ring-forming carbon atom of the fused 5-6 membered heterocycloalkyl ring is optionally substituted by oxo to form a carbonyl group; wherein the fused 5-6 membered heterocycloalkyl ring is optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 21 ; wherein the phenyl is further optionally substituted with 1, 2 or 3 substituents independently selected from R 20 ; and wherein Cy A  is attached to the pyrrazolopyridine core through the phenyl portion; R 2  is selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene, 5-10 membered heteroaryl-C 1-3  alkylene, halo, CN, OR a7 , SR a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 , NR c7 R d7 , NR c7 C(O)R b7 , NR c7 C(O)OR a7 , NR c7 S(O)R b7 , NR c7 S(O) 2 R b7 , NR c7 S(O) 2 NR c7 R d7 , S(O)R b7 , S(O)NR c7 R d7 , S(O) 2 R b7 , and S(O) 2 NR c7 R d7 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene and 5-10 membered heteroaryl-C 1-3  alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 30 ; each R 10  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene, 5-10 membered heteroaryl-C 1-3  alkylene, halo, CN, NO 2 , OR a1 , SR a1 C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , NR c1 R d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R d1 , C(\u2550NR e1 )R b1 , C(\u2550NOR a1 )R b1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , NR 1 S(O)R b1 , NR 1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , and S(O) 2 NR c1 R d1 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene and 5-10 membered heteroaryl-C 1-3  alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 11 ; or two R 10  substituents taken together with the carbon atom to which they are attached form a spiro 3-7-membered heterocycloalkyl ring, or a spiro C 3-6  cycloalkyl ring; wherein each spiro 3-7-membered heterocycloalkyl ring has at least one ring-forming carbon atom and 1, 2 or 3, ring-forming heteroatoms independently selected from N, O, and S; wherein a ring-forming carbon atom of each spiro 3-7-membered heterocycloalkyl ring is optionally substituted by oxo to form a carbonyl group; and wherein the spiro 3-7-membered heterocycloalkyl ring and spiro C 3-6  cycloalkyl ring are each optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 11 ; each R 11  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene, 5-10 membered heteroaryl-C 1-3  alkylene, halo, CN, OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 S(O)R b3 , NR c3 S(O) 2 R b3 , NR c3 S(O) 2 NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , and S(O) 2 NR c3 R d3 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene and 5-10 membered heteroaryl-C 1-3  alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 12 ; each R 12  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, CN, OR a5 , SR a5 , C(O)R b5 , C(O)NR c5 R d5 , C(O)OR a5 , NR c5 R d5 , NR c5 C(O)R b5 , NR c5 C(O)OR a5 , NR c5 S(O)R b5 , NR c5 S(O) 2 R b5 , NR c5 S(O) 2 NR c5 R d5 , S(O)R b5 , S(O)NR c5 R d5 , S(O) 2 R b5 , and S(O) 2 NR c5 R d5 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; each R 20  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene, 5-10 membered heteroaryl-C 1-3  alkylene, halo, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , NR c2 R d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2 , C(\u2550NR e2 )R b2 , C(\u2550NOR a2 )R b2 , C(\u2550NR e2 )NR c2 R d2 , NR c2 C(\u2550NR e2 )NR c2 R d2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R b2 , NR c2 S(O) 2 NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 NR c2 R d2 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene and 5-10 membered heteroaryl-C 1-3  alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 21 ; or two R 20  substituents taken together with the carbon atoms to which they are attached form a fused 4-7-membered heterocycloalkyl ring, or a fused C 4-6  cycloalkyl ring; wherein each fused 4-7-membered heterocycloalkyl ring has at least one ring-forming carbon atom and 1, 2 or 3, ring-forming heteroatoms independently selected from N, O, and S; wherein a ring-forming carbon atom of each fused 4-7-membered heterocycloalkyl ring or fused C 4-6  cycloalkyl ring is optionally substituted by oxo to form a carbonyl group; and wherein the fused 4-7-membered heterocycloalkyl ring and fused C 4-6  cycloalkyl ring are each optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 21 ; each R 21  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene, 5-10 membered heteroaryl-C 1-3  alkylene, halo, CN, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 S(O)R b4 , NR c4 S(O) 2 R b4 , NR c4 S(O) 2 NR c4 R d4 , S(O)R b4 , S(O)NR c4 R d4 , S(O) 2 R b4 , and S(O) 2 NR c4 R d4 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, C 3-10  cycloalkyl-C 1-3  alkylene, 4-10 membered heterocycloalkyl-C 1-3  alkylene, C 6-10  aryl-C 1-3  alkylene and 5-10 membered heteroaryl-C 1-3  alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 22 ; or two R 21  substituents taken together with the carbon atom to which they are attached form a spiro 3-7-membered heterocycloalkyl ring, or a spiro C 3-6  cycloalkyl ring; wherein each spiro 3-7-membered heterocycloalkyl ring has at least one ring-forming carbon atom and 1, 2 or 3, ring-forming heteroatoms independently selected from N, O, and S; wherein a ring-forming carbon atom of each spiro 3-7-membered heterocycloalkyl ring is optionally substituted by oxo to form a carbonyl group; and wherein the spiro 3-7-membered heterocycloalkyl ring and spiro C 3-6  cycloalkyl ring are each optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 22 ; each R 22  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, CN, OR a6 , SR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , NR c6 R d6 , NR c6 C(O)R b6 , NR c6 C(O)OR a6 , NR c6 S(O)R b6 , NR c6 S(O) 2 R b6 , NR c6 S(O) 2 NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O) 2 R b6 , and S(O) 2 NR c6 R d6 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; each R 30  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, CN, OR a8 , SR a8 , C(O)R b8 , C(O)NR c8 R d8 , C(O)OR a8 , NR c8 R d8 , NR c8 C(O)R b8 , NR c8 C(O)OR a8 , NR c8 S(O)R b8 , NR c8 S(O) 2 R b8 , NR c8 S(O) 2 NR c8 R d8 , S(O)R b8 , S(O)NR c8 R d8 , S(O) 2 R b8 , and S(O) 2 NR c8 R d8 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; each R a , R c  and R d  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 10 ; or any R c  and R d  attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 10 ; R b  is selected from C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6-10  aryl, and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 10 ; R e  is selected from H, CN, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkylthio, C 1-6  alkylsulfonyl, C 1-6  alkylcarbonyl, C 1-6  alkylaminosulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, aminosulfonyl, C 1-6  alkylaminosulfonyl and di(C 1-6  alkyl)aminosulfonyl; R j  is selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 10 ; R k  is selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 10 ; each R a1 , R c1  and R d1  is independently selected from H, C 2-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 2-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 11 ; or any R c1  and R d1  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 11 ; each R b1  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 11 ; each R e1  is independently selected from H, CN, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkylthio, C 1-6  alkylsulfonyl, C 1-6  alkylcarbonyl, C 1-6  alkylaminosulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, aminosulfonyl, C 1-6  alkylaminosulfonyl and di(C 1-6  alkyl)aminosulfonyl; each R a2 , R c2  and R d2 , is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 21 ; or any R c2  and R d2  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 21 ; each R b2  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 21 ; each R e2  is independently selected from H, CN, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkylthio, C 1-6  alkylsulfonyl, C 1-6  alkylcarbonyl, C 1-6  alkylaminosulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, aminosulfonyl, C 1-6  alkylaminosulfonyl and di(C 1-6  alkyl)aminosulfonyl; each R a3 , R c3  and R d3 , is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 12 ; or any R c3  and R d3  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R 12 ; each R b3  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 12 ; each R a4 , R c4  and R d4 , is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 22 ; or any R c4  and R d4  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R 22 ; each R b4  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 22 ; each R a5 , R c5  and R d5 , is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl and C 1-6  haloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl and C 2-6  alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; each R b5  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl and C 1-6  haloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl and C 2-6  alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; each R a6 , R c6  and R d6  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl and C 1-6  haloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl and C 2-6  alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; each R b6  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, and C 1-6  haloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl and C 2-6  alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; each R a7 , R c7 , and R d7  is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 30 ; or any R c7  and R d7  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R 30 ; each R b7  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10  aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 30 ; each R a8 , R c8  and R d8 , is independently selected from H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; or any R c8  and R d8  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R g ; each R b8  is independently selected from C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; and each R g  is independently selected from OH, NO 2 , CN, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-2  alkylene, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-3  alkoxy-C 1-3  alkyl, C 1-3  alkoxy-C 1-3  alkoxy, HO\u2014C 1-3  alkoxy, HO\u2014C 1-3  alkyl, cyano-C 1-3  alkyl, H 2 N\u2014C 1-3  alkyl, amino, C 1-6  alkylamino, di(C 1-6  alkyl)amino, thio, C 1-6  alkylthio, C 1-6  alkylsulfinyl, C 1-6  alkylsulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, carboxy, C 1-6  alkylcarbonyl, C 1-6  alkoxycarbonyl, C 1-6  alkylcarbonylamino, C 1-6  alkylsulfonylamino, aminosulfonyl, C 1-6  alkylaminosulfonyl, di(C 1-6  alkyl)aminosulfonyl, aminosulfonylamino, C 1-6  alkylaminosulfonylamino, di(C 1-6  alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6  alkylaminocarbonylamino, and di(C 1-6  alkyl)aminocarbonylamino.

Metadata:
- Claim Count in Document: 70.0
- Percentile: 88.0
- Lexical Diversity: 1.31429
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15698768', '15698788', '12704404', '11980314', '13245333']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8157432035705688
- 35 USC 102 Novelty (BERT): 0.5494311071343815
- Combined Prediction Score: 0.7891119939269501
- Mean Citation Score: 363.79944
- Max Citation Score: 405.0963
- Similarity Product: 367.52986667540085

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test