PATENT CLAIM ANALYSIS

Application Number: 15945887
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["424", "134100"]

Abstract:
Disclosed are tumor necrosis factor receptor 1B (TNFR-1B) signaling targets and TNFR-1B mutants and their uses for treatment of diseases and disorders.

Claim (Index 14):
A method for screening for a candidate compound for treating a disease or disorder selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, juvenile idiopathic arthritis, inflammation, autoimmune disease, immune disorder, Crohn's disease, ulcerative colitis and inflammatory bowel disease, the method comprising testing a modified TNFR-1B compound or mutant to determine if the modified TNFR-1B compound or mutant has modified binding affinity for one or more of ICOS-L, MadCAM-1 and ISLR2, wherein a modified TNFR-1B compound or mutant that is tested and determined to have modified binding affinity for one or more of ICOS-L, MadCAM-1 and ISLR2 is a candidate compound or mutant for treating a disease or disorder selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, juvenile idiopathic arthritis, inflammation, autoimmune disease, immune disorder, Crohn's disease, ulcerative colitis and inflammatory bowel disease.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 91.0
- Lexical Diversity: 1.13636
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14003756', '14849963', '14122611', '14211604', '13761864']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6278241116285751
- 35 USC 102 Novelty (BERT): 0.537557273519076
- Combined Prediction Score: 0.6187974278176251
- Mean Citation Score: 311.067136
- Max Citation Score: 355.4463
- Similarity Product: 224.1817370891512

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test