PATENT CLAIM ANALYSIS

Application Number: 16026577
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["514", "04400R"]

Abstract:
The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.

Claim (Index 38):
A composition for delivery of messenger RNA (mRNA) comprising an mRNA encoding a protein encapsulated within a liposome, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof, wherein: p is an integer of between 1 and 9, inclusive; each instance of R 2  is independently hydrogen or optionally substituted C 1-6  alkyl; each instance of R 6  and R 7  is independently a group of the formula (i), (ii), or (iii); Formulae (i), (ii), and (iii) are: wherein: each instance of R\u2032 is independently hydrogen or optionally substituted alkyl;\n X is O, S, or NR X , wherein R X  is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group; Y is O, S, or NR Y , wherein R v  is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group; \n R P  is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, or a nitrogen protecting group when attached to a nitrogen atom; and \n R L  is optionally substituted C 1-50  alkyl, optionally substituted C 2-50  alkenyl, optionally substituted C 2-50  alkynyl, optionally substituted heteroC 1-50  alkyl, optionally substituted heteroC 2-50  alkenyl, optionally substituted heteroC 2-50  alkynyl, or a polymer.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 95.0
- Lexical Diversity: 1.57143
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14521161', '15451312', '14521323', '15349720', '13662002']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7912720371772255
- 35 USC 102 Novelty (BERT): 0.6519963697165997
- Combined Prediction Score: 0.777344470431163
- Mean Citation Score: 526.772714
- Max Citation Score: 725.2799
- Similarity Product: 584.4302125890672

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test