PATENT CLAIM ANALYSIS

Application Number: 15917560
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "001100"]

Abstract:
The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involves (1) synthesizing a peptide from a selected number of natural or non-natural amino acids, wherein said peptide comprises at least two moieties capable of undergoing reaction to promote carbon-carbon bond formation; and (2) contacting said peptide with a reagent to generate at least one crosslinker and to effect stabilization of a secondary structure motif. The present invention, in a preferred embodiment, provides stabilized p53 donor helical peptides. Additionally, the present invention provides methods for disrupting the p53/MDM2 binding interaction comprising (1) providing a crosslinked stabilized α-helical structure; and (2) contacting said crosslinked stabilized α-helical structure with MDM2.

Claim (Index 29):
The method of  claim 24 , wherein the peptide comprises a binding site of a donor helix of the first protein.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 90.0
- Lexical Diversity: 1.9
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14068844', '11148976', '15287513', '09574086', '13680905']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7909669600230278
- 35 USC 102 Novelty (BERT): 0.5735265442291216
- Combined Prediction Score: 0.7692229184436372
- Mean Citation Score: 465.362882
- Max Citation Score: 499.3211
- Similarity Product: 364.3478056333423

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test