PATENT CLAIM ANALYSIS

Application Number: 16024145
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "250100"]

Abstract:
The present invention generally provides methods and compositions for eliciting an immune response against  Neisseria  spp. bacteria in a subject, particularly against a  Neisseria meningitidis  serogroup B strain.

Claim (Index 68):
A composition comprising:\n isolated antigenic vesicles prepared from a  Neisseria meningitidis  ( N. meningitidis ) that is genetically modified to overexpress a meningococcal GNA1870 polypeptide, wherein the overexpression consists of the overexpression of a full-length meningococcal GNA1870 polypeptide in the antigenic vesicles at a level that is greater than 3 to 10 times the level of the endogenous GNA1870 polypeptide expressed by unmodified parental  N. meningitidis  from which the genetically modified  N. meningitidis  is obtained, wherein the composition when administered to a mammalian subject, elicits serum antibodies specific to the overexpressed GNA1870 polypeptide that are bactericidal against at least three  Neisseria meningitidis  strains that express a GNA1870 polypeptide and a heterologous meningococcal PorA protein, wherein the overexpressed GNA1870 polypeptide is a variant 1, a variant 2, or a variant 3 GNA1870 polypeptide, and a pharmaceutically acceptable carrier.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 94.0
- Lexical Diversity: 1.14815
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15237495', '14688594', '11795739', '13279006', '09917222']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8316972239557144
- 35 USC 102 Novelty (BERT): 0.7325519832387629
- Combined Prediction Score: 0.8217826998840193
- Mean Citation Score: 799.49578
- Max Citation Score: 888.7611
- Similarity Product: 795.5839862331392

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test