PATENT CLAIM ANALYSIS

Application Number: 15953083
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "178000"]

Abstract:
The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated by NFkB, IL-6, IL-6-R, NADPH oxidase (Nox), and/or superoxide and/or hydrogen peroxide production by a NADPH oxidase, including for example ameliorating, treating, reversing or preventing schizophrenia, psychosis, delirium, e.g., post-operative delirium, drug-induced psychosis, psychotic features associated with frailty syndrome (FS), aging, depression, dementias; traumatic war neurosis, post traumatic stress disorder (PTSD) or post-traumatic stress syndrome (PTSS), Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease), and/or Multiple Sclerosis (MS). The invention also provides methods for purifying a C60 fullerene, C 3  (tris malonic acid C60) or malonic acid derivatives.

Claim (Index 13):
The method of  claim 12 , wherein administering the C60 malonic acid derivative in vivo to an individual in need thereof treats, ameliorates, slows the progress of or reverses: a schizophrenia; a psychosis; a delirium, optionally a post-operative delirium; a drug-induced psychosis or a psychotic feature; frailty syndrome (FS), a cognitive impairment, or a learning or memory impairment, resulting from or associated with frailty syndrome (FS), aging, depression, dementia; a traumatic war neurosis; a post traumatic stress disorder (PTSD) or a post-traumatic stress syndrome (PTSS); Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease); Multiple Sclerosis (MS); a cognitive, learning or memory impairment; a CNS inflammation, optionally a CNS inflammation resulting from a trauma or an inflammation, optionally an inflammation from a CNS infection; Alzheimer's disease; Lewy Body Disease; Parkinson's Disease; Huntington's Disease; a dementia, optionally a multi-infarct dementia (vascular dementia) or a senile dementia; or, Frontotemporal Dementia (Pick's Disease).

Metadata:
- Claim Count in Document: 5.0
- Percentile: 91.0
- Lexical Diversity: 1.81818
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15136787', '12681743', '14358571', '13970639', '14888390']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7716057270453908
- 35 USC 102 Novelty (BERT): 0.6369735449758925
- Combined Prediction Score: 0.758142508838441
- Mean Citation Score: 411.3179859999999
- Max Citation Score: 801.0581
- Similarity Product: 514.3896586776018

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test