PATENT CLAIM ANALYSIS

Application Number: 15979041
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "402000"]

Abstract:
The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to bisantrene or derivatives, analogs, or prodrugs thereof.

Claim (Index 13):
The method of  claim 12  wherein the drug therapy comprises the administration of bisantrene and wherein the patient selection is a patient selection carried out by a criterion selected from the group consisting of:\n (a) selecting patients with a disease condition characterized by a high level of a metabolic enzyme selected from the group consisting of histone deacetylase, protein kinases, and ornithine decarboxylase; \n (b) selecting patients with a disease condition characterized by a low level of a metabolic enzyme selected from the group consisting of histone deacetylase, protein kinases, and ornithine decarboxylase; \n (c) selecting patients with a low or high susceptibility to a condition selected from the group consisting of thrombocytopenia and neutropenia; \n (d) selecting patients intolerant of GI toxicities; \n (e) selecting patients characterized by over- or under-expression of a gene selected from the group consisting of jun, GPCRs, signal transduction proteins, VEGF, prostate specific genes, protein kinases, and telomerase; \n (f) selecting patients as the result of immune screening; \n (g) selecting patients as the result of DNA methylation screening; \n (h) selecting patients with recurrent disease characterized by the duration of their initial response; \n (i) selecting patients without mutations in p53; and \n (j) selecting for patients without extensive prior treatment.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 93.0
- Lexical Diversity: 1.31579
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14907728', '14907729', '13817096', '14753911', '14245738']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7891950231599796
- 35 USC 102 Novelty (BERT): 0.531613086653059
- Combined Prediction Score: 0.7634368295092875
- Mean Citation Score: 267.787678
- Max Citation Score: 348.62634
- Similarity Product: 291.68232582573296

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test