PATENT CLAIM ANALYSIS

Application Number: 15911062
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "567000"]

Abstract:
Formulations containing pharmaceutically active compounds with improved stability.

Claim (Index 23):
A formulation comprising:\n a compound of formula II: or a pharmaceutically acceptable salt thereof, wherein: Y is selected from \u2014O\u2014, \u2014S\u2014, \u2014N(R 12 )\u2014, and \u2014C(R 4 )(R 5 )\u2014; W 1  is selected from C 1 -C 6  alkyl, C 0 -C 6  alkyl, C 3 -C 6  cycloalkyl, aryl and Het, wherein said C 1 -C 8  alkyl, C 3 -C 8  cycloalkyl, Ar and Het are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl, \u2014C 0 -C 6  alkyl-CO 2 R 12 , \u2014C 0 -C 6  alkyl-C(O)SR 12 , \u2014C 0 -C 6  alkyl-CONR 13 R 14 , \u2014C 0 -C 6  alkyl-COR 15 , \u2014C 0 -C 6  alkyl-NR 13 R 14 , \u2014C 0 -C 6  alkyl-SR 12 , \u2014C 0 -C 6  alkyl-OR 12 , \u2014C 0 -C 6  alkyl-SO 3 H, \u2014C 0 -C 6  alkyl-SO 2 NR 13 R 14 , \u2014C 0 -C 6  alkyl-SO 2 R 12 , \u2014C 0 -C 6  alkyl-SOR 15 , \u2014C 0 -C 6  alkylOCOR 15 , \u2014C 0 -C 6  alkyl-OC(O)NR 13 R 14 , \u2014C 0 -C 6  alkyl-OC(O)OR 15 , \u2014C 0 -C 6  alkyl-NR 13 C(O)OR 15 , \u2014C 0 -C 6  alkyl-NR 13 C(O)NR 13 R 14 , and \u2014C 0 -C 6  alkyl-NR 13 COR 15 , where said C 1 -C 6  alkyl, is optionally unsubstituted or substituted by one or more halo substituents; W 2  is selected from H, halo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, \u2014C 0 -C 6  alkyl-NR 13 R 14 , \u2014C 0 -C 6  alkyl-SR 12 , \u2014C 0 -C 6  alkyl-OR 12 , \u2014C 0 -C 6  alkylCO 2 R 12 , \u2014C 0 -C 6  alkyl-C(O)SR 12 , \u2014C 0 -C 6  alkylCONR 13 R 14 , \u2014C 0 -C 6  alkyl-COR 15 , \u2014C 0 -C 6  alkylOCOR 15 , \u2014C 0 -C 6  alkyl-OCONR 13 R 14 , \u2014C 0 -C 6  alkyl-NR 13 CONR 13 R 14 , \u2014C 0 -C 6  alkyl-NR 13 COR 15 , \u2014C 0 -C 6  alkyl-Het, \u2014C 0 -C 6  alkyl-Ar, and \u2014C 0 -C 6  alkyl-C 3 -C 7  cycloalkyl, wherein said C 1 -C 6  alkyl is optionally unsubstituted or substituted by one or more halo substituents, and wherein the C 3 -C 7  cycloalkyl, Ar and Het moieties of said \u2014C 0 -C 6  alkyl-Het, \u2014C 0 -C 6  alkyl-Ar and \u2014C 0 -C 6  alkyl-C 3 -C 7  cycloalkyl are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl, \u2014C 0 -C 6  alkyl-CO 2 R 12 , \u2014C 0 -C 6  alkyl-C(O)SR 12 , \u2014C 0 -C 6  alkyl-CONR 13 R 14 , \u2014C 0 -C 6  alkyl-COR 15 , \u2014C 0 -C 6  alkyl-NR 13 R 14 , \u2014C 0 -C 6  alkyl-SR 12 , \u2014C 0 -C 6  alkyl-OR 12 , \u2014C 0 -C 6  alkyl-SO 3 H, \u2014C 0 -C 6  alkyl-SO 2 NR 13 R 14 , \u2014C 0 -C 6  alkyl-SO 2 R 12 , \u2014C 0 -C 6  alkyl-SOR 15 , \u2014C 0 -C 6  alkyl-OCOR 15 , \u2014C 0 -C 6  alkyl-OC(O)NR 13 R 14 , \u2014C 0 -C 6  alkyl-OC(O)OR 15 , \u2014C 0 -C 6  alkyl-NR 13 C(O)OR 15 , \u2014C 0 -C 6  alkyl-NR 13 C(O)NR 13 R 14 , and \u2014C 0 -C 6  alkyl-NR 13 COR 15 , where said C 1 -C 6  alkyl, is optionally unsubstituted or substituted by one or more halo substituents; W 3  is selected from the group consisting of: H, halo, C 1 -C 6  alkyl, \u2014C 0 -C 6  alkyl-NR 13 R 14 , \u2014C 0 -C 6  alkylSR 12 , \u2014C 0 -C 6  alkyl-OR 12 , \u2014C 0 -C 6  alkyl-CO 2 R 12 , \u2014C 0 -C 6  alkyl-C(O)SR 12 , \u2014C 0 -C 6  alkyl-CONR 13 R 14 , \u2014C 0 -C 6  alkyl-COR 15 , \u2014C 0 -C 6  alkyl-OCOR 15 , \u2014C 0 -C 6  alkyl-OCONR 13 R 14 , \u2014C 0 -C 6  alkylNR 13 CONR 13 R 14 , \u2014C 0 -C 6  alkyl-NR 13 COR 15 , \u2014C 0 -C 6  alkyl-Het, \u2014C 1 -C 6  alkyl-Ar and \u2014C 1 -C 6  alkyl-C 3 -C 7  cycloalkyl, wherein said C 1 -C 6  alkyl is optionally unsubstituted or substituted by one or more halo substituents; Q is selected from C 3 -C 8  cycloalkyl, Ar, and Het; wherein said C 3 -C 8  cycloalkyl, Ar, and Het are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl, \u2014C 0 -C 6  alkylCO 2 R 12 , \u2014C 0 -C 6  alkyl-C(O)SR 12 , \u2014C 0 -C 6  alkylCONR 13 R 14 , \u2014C 0 -C 6  alkyl-COR 15 , \u2014C 0 -C 6  alkylNR 13 R 14 , \u2014C 0 -C 6  alkyl-SR 12 , \u2014C 0 -C 6  alkyl-OR 12 , \u2014C 0 -C 6  alkyl-SO 3 H, \u2014C 0 -C 6  alkyl-SO 2 NR 13 R 14 , \u2014C 0 -C 6  alkyl-SO 2 R 12 , \u2014C 0 -C 6  alkyl-SOR 15 , \u2014C 0 -C 6  alkyl-OCOR 15 , \u2014C 0 -C 6  alkyl-OC(O)NR 13 R 14 , \u2014C 0 -C 6  alkyl-OC(O)OR 15 , \u2014C 0 -C 6  alkylNR 13 C(O)OR 15 , \u2014C 0 -C 6  alkyl-NR 13 C(O)NR 13 R 14 , and \u2014C 0 -C 6  alkyl-NR 13 COR 15 , where said C 1 -C 6  alkyl is optionally unsubstituted or substituted by one or more halo substituents; p is 0-8; n is 2-8; m is 0 or 1; q is 0 or 1; each R 1  and R 2  are independently selected from H, halo, C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl, \u2014C 0 -C 6  alkyl-NR 13 R 14 , \u2014C 0 -C 6  alkyl-OR 12 , \u2014C 0 -C 6  alkyl-SR 12 , \u2014C 1 -C 6  alkyl-Het, \u2014C 1 -C 6  alkyl-Ar, and \u2014C 1 -C 6  alkyl-C 3 -C 7  cycloalkyl, or R 1  and R 2  together with the carbon to which they are attached form a 3-5 membered carbocyclic or heterocyclic ring, wherein said heterocyclic ring contains one, or more heteroatoms selected from N, O, and S, where any of said C 1 -C 6  alkyl is optionally unsubstituted or substituted by one or more halo substituents; each R 3  is the same or different and is independently selected from halo, cyano, nitro, C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl, \u2014C 0 -C 6  alkyl-Ar, \u2014C 0 -C 6  alkyl-Het, \u2014C 0 -C 6  alkyl-C 3 -C 7  cycloalkyl, \u2014C 0 -C 6  alkyl-CO 2 R 12 , \u2014C 0 -C 6  alkyl-C(O)SR 12 , \u2014C 0 -C 6  alkyl-CONR 13 R 14 , \u2014C 0 -C 6  alkyl-COR 15 , \u2014C 0 -C 6  alkyl-NR 13 R 14 , \u2014C 0 -C 6  alkyl-SR 12 , \u2014C 0 -C 6  alkyl-OR 12 , \u2014C 0 -C 6  alkyl-SO 3 H, \u2014C 0 -C 6  alkylSO 2 NR 13 R 14 , \u2014C 0 -C 6  alkyl-SO 2 R 12 , \u2014C 0 -C 6  alkylSOR 15 , \u2014C 0 -C 6  alkyl-OCOR 15 , \u2014C 0 -C 6  alkyl-OC(O)NR 13 R 14 , \u2014C 0 -C 6  alkyl-OC(O)OR 15 , \u2014C 0 -C 6  alkyl-NR 13 C(O)OR 15 , \u2014C 0 -C 6  alkyl-NR 13 C(O)NR 13 R 14 , and \u2014C 0 -C 6  alkyl-NR 13 COR 15 , wherein said C 1 -C 6  alkyl is optionally unsubstituted or substituted by one or more halo substituents; each R 4  and R 5  is independently selected from H, halo, C 1 -C 6  alkyl, \u2014C 0 -C 6  alkyl-Het, \u2014C 0 -C 6  alkyl-Ar, and \u2014C 0 -C 6  alkyl-C 3 -C 7  cycloalkyl; R 6  and R 7  are each independently selected from H, halo, C 1 -C 6  alkyl, \u2014C 0 -C 6  alkyl-Het, \u2014C 0 -C 6  alkyl-Ar and \u2014C 0 -C 6  alkyl-C 3 -C 7  cycloalkyl; R 8  and R 9  are each independently selected from H, halo, C 1 -C 6  alkyl, \u2014C 0 -C 6  alkyl-Het, \u2014C 0 -C 6  alkyl-Ar and \u2014C 0 -C 6  alkyl-C 3 -C 7  cycloalkyl; R 10  and R 11  are each independently selected from H, C 1 -C 12  alkyl, C 3 -C 12  alkenyl, C 3 -C 12  alkynyl, \u2014C 0 -C 8  alkyl-Ar, \u2014C 0 -C 8  alkyl-Het, \u2014C 0 -C 8  alkyl-C 3 -C 7  cycloalkyl, \u2014C 0 -C 8  alkyl-O\u2014Ar, \u2014C 0 -C 8  alkyl-O-Het, \u2014C 0 -C 8  alkyl-O\u2014C 3 -C 7  cycloalkyl, \u2014C 0 -C 8  alkyl-S(O) x \u2014C 0 -C 8  alkyl, \u2014C 0 -C 8  alkyl-S(O) x \u2014Ar, \u2014C 0 -C 8  alkyl-S(O) x -Het, \u2014C 0 -C 8  alkyl-S(O) x \u2014C 3 -C 7  cycloalkyl, \u2014C 0 -C 8  alkyl-NH\u2014Ar, \u2014C 0 -C 8  alkyl-NH-Het, \u2014C 0 -C 8  alkyl-NH\u2014C 3 -C 7  cycloalkyl, \u2014C 0 -C 8  alkyl-N(C 1 -C 4  alkyl)-Ar, \u2014C 0 -C 8  alkyl-N(C 1 -C 4  alkyl)-Het, \u2014C 0 -C 8  alkyl-N(C 1 -C 4  alkyl-C 3 -C 7  cycloalkyl, \u2014C 0 -C 8  alkyl-Ar, \u2014C 0 -C 8  alkyl-Het, and \u2014C 0 -C 8  alkyl-C 3 -C 7  cycloalkyl, where x is 0, 1, or 2, or R 10  and R 11 , together with the nitrogen to which they are attached, form a 4-7 membered heterocyclic ring which optionally contains one or more additional heteroatoms selected from N, O, and S, wherein said C 1 -C 12  alkyl, C 3 -C 12  alkenyl, or C 3 -C 12  alkynyl is optionally substituted by one or more of the substituents independently selected from the group halo, \u2014OH, \u2014SH, \u2014NH 2 , \u2014NH(unsubstituted C 1 -C 6  alkyl), \u2014N(unsubstituted C 1 -C 6  alkyl)(unsubstituted C 1 -C 6  alkyl), unsubstituted \u2014OC 1 -C 6  alkyl, \u2014CO 2 H, \u2014CO 2 (unsubstituted C 1 -C 6  alkyl), \u2014CONH 2 , \u2014CONH(unsubstituted C 1 -C 6  alkyl), \u2014CON(unsubstituted C 1 -C 6  alkyl)(unsubstituted C 1 -C 6  alkyl), \u2014SO 3 H, \u2014SO 2 NH 2 , \u2014SO 2 NH(unsubstituted C 1 -C 6  alkyl) and \u2014SO 2 N(unsubstituted C 1 -C 6  alkyl)(unsubstituted C 1 -C 6  alkyl); R 12  is selected from H, C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl, \u2014C 0 -C 6  alkyl-Ar, \u2014C 0 -C 6  alkyl-Het and \u2014C 0 -C 6  alkyl-C 3 -C 7  cycloalkyl; each R 13  and each R 14  are independently selected from H, C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl, \u2014C 0 -C 6  alkyl-Ar, \u2014C 0 -C 6  alkyl-Het, and \u2014C 0 -C 6  alkyl-C 3 -C 7  cycloalkyl, or R 13  and R 14  together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring which optionally contains one or more additional heteroatoms selected from N, O, and S; and R 15  is selected from C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl, \u2014C 0 -C 6  alkyl-Ar, \u2014C 0 -C 6  alkyl-Het, and \u2014C 0 -C 6  alkyl-C 3 -C 7  cycloalkyl; and a lipophilic vehicle, comprising at least one lipophilic excipient, in which the compound of the formula II, or the pharmaceutically acceptable salt thereof, is soluble.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10508791', '10508822', '10508894', '10508893', '11344937']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8262540634507852
- 35 USC 102 Novelty (BERT): 0.5544086178619816
- Combined Prediction Score: 0.7990695188919048
- Mean Citation Score: 416.907818
- Max Citation Score: 453.03735
- Similarity Product: 318.8845564424694

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test