PATENT CLAIM ANALYSIS

Application Number: 16054667
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["514", "221000"]

Abstract:
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Claim (Index 12):
A method of removing senescent cells from an eye of a subject in need thereof,\n wherein the senescent cells are identifiable as p16 positive cells that are not cancer cells, the method comprising contacting the senescent cells in the eye with an effective amount of (R)\u2014N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)-4-((4-(4-hydroxypiperidin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide, or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 96.0
- Lexical Diversity: 1.58333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16007880', '15956613', '15827539', '15647688', '15955542']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8578726264037766
- 35 USC 102 Novelty (BERT): 0.6248605931568674
- Combined Prediction Score: 0.8345714230790857
- Mean Citation Score: 721.4856400000001
- Max Citation Score: 735.4616
- Similarity Product: 498.87484250707627

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test