PATENT CLAIM ANALYSIS

Application Number: 15755636
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "243000"]

Abstract:
The invention relates generally to compounds that modulate the activity of TGFBETA R-1 and TGFBETA R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Claim (Index 1):
The compound of the formula wherein:\n A is \u2014NH-bicyclic heteroaryl or bicyclic heteroaryl, substituted with 0-2 R 2  groups; \n R 1  is aryl or heteroaryl, substituted with 0-3 R 6 ; \n R 2  is hydrogen, halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, \u2014CHF 2 , CF 3 , (C 3 -C 8 )cycloalkyl, \u2014NH 2  or NHSO 2 (C 1 -C 6 )alkyl; \n R 4  is hydrogen, halogen, (C 1 -C 6 )alkyl, \u2014CH 2 NR 7 R 8  or \u2014CONR 7 R 8 ; \n R 5  is hydrogen, halogen, \u2014CONHR 9 , \u2014CH 2 NHR 10 R 11  or \u2014NHR 10 R 11 ; \n R 6  is hydrogen, halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, \u2014CHF 2 , CF 3 , (C 3 -C 8 )cycloalkyl, \u2014NH 2  or NHSO 2 (C 1 -C 6 )alkyl; \n R 7  is hydrogen, amino(C 1 -C 6 )alkyl or hydroxy(C 1 -C 6 )alkyl; \n R 8  is hydrogen, amino(C 1 -C 6 )alkyl or hydroxy(C 1 -C 6 )alkyl; or \n R 7  and R 8  are taken together with the nitrogen to which they are attached to form a heterocyclic group; \n R 9  is hydrogen or (C 1 -C 6 )alkyl; \n R 10  is hydrogen or (C 1 -C 6 )alkyl \n R 11  is hydrogen or (C 1 -C 6 )alkyl; or \n R 10  and R 11  are taken together with the nitrogen to which they are attached to form a heterocyclic group; \n or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 88.0
- Lexical Diversity: 1.45161
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15747843', '14977709', '15430883', '14190477', '15746597']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7622779980046499
- 35 USC 102 Novelty (BERT): 0.5487630809610136
- Combined Prediction Score: 0.7409265063002862
- Mean Citation Score: 304.519028
- Max Citation Score: 385.2536
- Similarity Product: 330.132848259449

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test