PATENT CLAIM ANALYSIS

Application Number: 16243251
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["549", "419000"]

Abstract:
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

Claim (Index 1):
A method of preparing a compound of formula B2: comprising (a) combining a compound of formula B1 with a compound of formula A1, wherein the compound of formula B1 is and the compound of formula A1 is and wherein R is phenyl substituted by R 3 , R 4 , R 5 , R 6 , and R 7 ; and R 3 , R 4 , R 5 , R 6 , and R 7  are independently selected from the group consisting of H, halo, alkylsulfonyl, N-hydroxylsulfonamidyl, perhaloalkyl, nitro, aryl, cyano, alkoxy, perhaloalkoxy, alkyl, substituted aryloxy, alkylsulfanyl, alkylsulfinyl, heterocycloalkyl, substituted heterocycloalkyl, dialkylamino, cycloalkoxy, cycloalkylsulfanyl, arylsulfanyl and arylsulfinyl, provided that: (1) at least one of R 3 , R 4 , R 5 , R 6 , and R 7  is other than H; (2) at least one of R 3 , R 4 , R 5 , R 6 , and R 7  is other than halo; (3); when R 3 , R 4 , R 6 , and R 7  are H, R 5  is other than halo, nitro, cyano, alkyl or alkoxy; (4) when one of R 3  or R 7  is halo and the R 3  or R 7  that is not halo is H and one of R 4  or R 6  is halo and the R 4  or R 6  that is not halo is H, R 5  is other than halo; (5) when R 3 , R 7  and R 5  are H and one of R 4  and R 6  is H, the R 4  or R 6  that is not H is other than N-hydroxysulfonamidyl, perhaloalkyl or nitro; (6) when R 4 , R 5 , and R 6  are H and one of R 3  and R 7  is H, the R 3  or R 7  that is not H is other than nitro or alkyl; (7) when R 3  and R 7  are H, R 5  is nitro and one of R 4  and R 6  is H, the R 4  or R 6  that is not H is other than halo; (8) when R 4  and R 6  are nitro and R 3  and R 7  are H, R 5  is other than dialkylamino; (9) when R 4  and R 6  are H and R 3  and R 7  are alkyl, R 5  is other than alkyl; and (10) when R 3  and R 7  are H and R 4  and R 6  are nitro, R 5  is other than dialkylamino.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 99.0
- Lexical Diversity: 1.51923
- Patent Class: 549.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15286145', '13531364', '12239705', '14857308', '14815917']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7475604956844824
- 35 USC 102 Novelty (BERT): 0.5175766503751906
- Combined Prediction Score: 0.7245621111535533
- Mean Citation Score: 317.738606
- Max Citation Score: 324.2645
- Similarity Product: 266.0831097843647

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test