PATENT CLAIM ANALYSIS

Application Number: 15889589
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-02
Patent Classification: ["514", "588000"]

Abstract:
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general Formula I: or pharmaceutically acceptable salts thereof.

Claim (Index 1):
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein:\n a dashed line indicates an optional bond; \n X is CH or N; \n Y is absent or \u2014(CH 2 ) m \u2014; \n Z is NR 9 , CR 10 R 11 , or O; \n R 1  is H, C 1-6  alkyl, benzyl, OH, or C 1-6  alkoxy, wherein said C 1-6  alkyl, benzyl, or C 1-6  alkoxy is optionally substituted with 1-3 substituents selected from halo, OH, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  hydroxyalkyl, CO(C 1-6  alkyl); CHO; CO 2 H; CO 2 (C 1-6  alkyl), and C 1-6  haloalkyl; \n R 2  is H or C 1-6  alkyl; \n or R 1  and R 2  taken together with the N atoms to which they are attached form a 4-7-membered ring; \n R 3  and R 4  are each, independently, H, CN, halo, CHO, or CO 2 H, or optionally substituted C 1-6  alkyl, C 1-6  hydroxyalkyl, C 1-6  alkylcycloalkyl, C 1-6  haloalkyl, C 1-6  alkoxy, CO(C 1-6  alkyl), CO 2 (C 1-6  alkyl), or CONR 12 R 13 ; \n or R 3  and R 4  taken together with the C atom to which they are attached form a 3-6-membered ring; \n R 5  is halo, CN, CHO, CO 2 H, CO(C 1-6  alkyl), CO 2 (C 1-6  alkyl), NR 14 R 15 , NHCONR 14 R 15 , CONR 14 R 15 , C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, C 1-6  hydroxyalkyl, C 2-6  alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl, wherein said CO(C 1-6  alkyl), CO 2 (C 1-6  alkyl), NR 14 R 15 , NHCONR 14 R 15 , CONR 14 R 15 , C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, C 1-6  hydroxyalkyl, C 2-6  alkenyl, C 2-6  alkynyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl is optionally substituted with 1-3 substituents selected from halo, CN, OH, NO 2 , Si(CH 3 ) 4 , CHO, and CO 2 H, or optionally substituted CO(C 1-6  alkyl), CO 2 (C 1-6  alkyl), NR 14 R 15 , NHCONR 14 R 15 , CONR 14 R 15 , CH\u2550NOH, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, C 1-6  hydroxyalkyl, C 2-6  alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl; \n R 6  is absent or H; \n or R 1  and R 6  taken together with the atoms to which they are attached form a 4-6-membered ring; \n R 7  is H, CN, or halo; \n or two R 7  can be taken together with the atoms to which they are attached form a 5-6-membered ring; \n or R 5  and R 7  taken together with the atoms to which they are attached form an optionally substituted 5-6-membered ring; \n R 8  is H or C 1-6  alkyl; \n R 9  is H, C 1-6  alkyl, CO(C 1-6  alkyl); CHO; CO 2 H; or CO 2 (C 1-6  alkyl); \n R 10  and R 14  are each, independently, H, C 1-6  alkyl, or halo; \n R 12  and R 13  are each, independently, H or C 1-6  alkyl; \n R 14  and R 15  are each, independently H, C 1-6  alkyl, CO(C 1-6  alkyl), CO(heteroaryl), heteroaryl, or cycloalkyl; \n r is 1 or 2; \n s is 0-4; \n n is 0-3; and \n m is 1-3.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 88.0
- Lexical Diversity: 1.15625
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15368362', '14640551', '13791544', '13104450', '15648184']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8009154336506387
- 35 USC 102 Novelty (BERT): 0.6470081402215185
- Combined Prediction Score: 0.7855247043077267
- Mean Citation Score: 413.092948
- Max Citation Score: 621.8143299999998
- Similarity Product: 589.7541115512256

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test