PATENT CLAIM ANALYSIS

Application Number: 16071687
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["546", "087000"]

Abstract:
A compound of general formula A, useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof. General formula A R 1 =3-F, 3,4,5-OMe, 4-OMe, H, 4-CF 3 , 4-Cl, 4-OH-3-OMe, 3,4-CH 2 —O—CH 2 , 3,5-F, 4-OH, 1-napthyl, 9-phenanthryl, 4-Me. R 2 =3,4,5-OMe, 3,4-Cl, 4-F, 3,5-F, 2,5-OMe, 4-Cl, 4-OH-3-OMe, 3-OH, 3,4,5-OH, 4-CF 3 , 4-OMe, 4-NH 2

Claim (Index 2):
The compound of Formula A as claimed in  claim 1 , wherein the representative compounds of formula 1a-l to 13a-l comprises;\n (E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl) acrylamide (1a) (E)-3-(3,4-dichlorophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1b) (E)-3-(4-fluorophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1c) (E)-3-(3,5-difluorophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1e) (E)-3-(4-chlorophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1f) (E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (1g) (E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3-hydroxyphenyl)acrylamide (1h) (E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (1i) (E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (1j) (E)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-methoxyphenyl)acrylamide (1k) (E)-3-(4-aminophenyl)-N-((1-(3-fluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (1l) (E)-3-(3,4,5-trimethoxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2a) (E)-3-(3,4-dichlorophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2b) (E)-3-(4-fluorophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2c) (E)-3-(3,5-difluorophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2e) (E)-3-(4-chlorophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2f) (E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2g) (E)-3-(3-hydroxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2h) (E)-3-(3,4,5-trihydroxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2i) (E)-3-(4-(trifluoromethyl)phenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2j) (E)-3-(4-methoxyphenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2k) (E)-3-(4-aminophenyl)-N-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (2l) (E)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (3a) (E)-3-(3,4-dichlorophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3b) (E)-3-(4-fluorophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3c) (E)-3-(3,5-difluorophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3e) (E)-3-(4-chlorophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3f) (E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3g) (E)-3-(3-hydroxyphenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3h) (E)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (3i) (E)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (3j) (E)-3-(4-methoxyphenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3k) (E)-3-(4-aminophenyl)-N-((1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (3l) (E)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (4a) (E)-3-(3,4-dichlorophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4b) (E)-3-(4-fluorophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4c) (E)-3-(3,5-difluorophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4e) (E)-3-(4-chlorophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4f) (E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4g) (E)-3-(3-hydroxyphenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4h) (E)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (4i); (E)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (4j) (E)-3-(4-methoxyphenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4k) (E)-3-(4-aminophenyl)-N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (4l) (E)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (5a) (E)-3-(3,4-dichlorophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5b) (E)-3-(4-fluorophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5c) (E)-3-(3,5-difluorophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5e) (E)-3-(4-chlorophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5f) (E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5g) (E)-3-(3-hydroxyphenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5h) (E)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (5i) (E)-3-(4-(trifluoromethyl)phenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5j) (E)-3-(4-methoxyphenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5k) (E)-3-(4-aminophenyl)-N-((1-(4-(trifluoromethyl)phenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (5l) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (6a) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4-dichlorophenyl)acrylamide (6b) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-fluorophenyl)acrylamide (6c) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,5-difluorophenyl)acrylamide (6d) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(2,5-dimethoxyphenyl)acrylamide (6e) (E)-3-(4-chlorophenyl)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (6f) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (6g) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3-hydroxyphenyl)acrylamide (6h) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (6i) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (6j) (E)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-methoxyphenyl)acrylamide (6k) (E)-3-(4-aminophenyl)-N-((1-(4-chlorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (6l) (E)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (7a) (E)-3-(3,4-dichlorophenyl)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (7b) (E)-3-(4-fluorophenyl)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (7c) (E)-3-(3,5-difluorophenyl)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (7d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (7e) (E)-3-(4-chlorophenyl)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (7f) (E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (7g) (E)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3-hydroxyphenyl)acrylamide (7h) (E)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (7i) (E)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (7j) (E)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-methoxyphenyl)acrylamide (7k) (E)-3-(4-aminophenyl)-N-((1-(4-hydroxy-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (7l) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (8a) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4-dichlorophenyl)acrylamide (8b) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-fluorophenyl)acrylamide (8c) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,5-difluorophenyl)acrylamide (8d) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(2,5-dimethoxyphenyl)acrylamide (8e) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-chlorophenyl)acrylamide (8f) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (8g) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3-hydroxyphenyl)acrylamide (8h) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (8i) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (8j) (E)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-methoxyphenyl)acrylamide (8k) (E)-3-(4-aminophenyl)-N-((1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (8l) (E)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (9a) (E)-3-(3,4-dichlorophenyl)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (9b) (E)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-fluorophenyl)acrylamide (9c) (E)-3-(3,5-difluorophenyl)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (9d) (E)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(2,5-dimethoxyphenyl)acrylamide (9e) (E)-3-(4-chlorophenyl)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (9f) (E)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (9g) (E)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3-hydroxyphenyl)acrylamide (9h) (E)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (9i) (E)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (9j) (E)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-methoxyphenyl)acrylamide (9k) (E)-3-(4-aminophenyl)-N-((1-(3,5-difluorophenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (9l) (E)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (10a) (E)-3-(3,4-dichlorophenyl)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (10b) (E)-3-(4-fluorophenyl)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (10c) (E)-3-(3,5-difluorophenyl)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (10d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (10e) (E)-3-(4-chlorophenyl)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (10f) (E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (10g) (E)-3-(3-hydroxyphenyl)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (10h) (E)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (10i) (E)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (10j) (E)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-methoxyphenyl)acrylamide (10k) (E)-3-(4-aminophenyl)-N-((1-(4-hydroxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (10l) (E)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (11a) (E)-3-(3,4-dichlorophenyl)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (11b) (E)-3-(4-fluorophenyl)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (11c) (E)-3-(3,5-difluorophenyl)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (11d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (11e) (E)-3-(4-chlorophenyl)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (11f) (E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (11g) (E)-3-(3-hydroxyphenyl)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (11h) (E)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (11i) (E)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (11j) (E)-3-(4-methoxyphenyl)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (11k) (E)-3-(4-aminophenyl)-N-((1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (11l) (E)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (12a) (E)-3-(3,4-dichlorophenyl)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (12b) (E)-3-(4-fluorophenyl)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (12c) (E)-3-(3,5-difluorophenyl)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (12d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (12e) (E)-3-(4-chlorophenyl)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (12f) (E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (12g) (E)-3-(3-hydroxyphenyl)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (12h) (E)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (12i) (E)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (12j) (E)-3-(4-methoxyphenyl)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (12k) (E)-3-(4-aminophenyl)-N-((1-(phenanthren-9-yl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (12l) (E)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (13a) (E)-3-(3,4-dichlorophenyl)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (13b) (E)-3-(4-fluorophenyl)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (13c) (E)-3-(3,5-difluorophenyl)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (13d) (E)-3-(2,5-dimethoxyphenyl)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (13e) (E)-3-(4-chlorophenyl)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (13f) (E)-3-(4-hydroxy-3-methoxyphenyl)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (13g) (E)-3-(3-hydroxyphenyl)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (13h) (E)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(3,4,5-trihydroxyphenyl)acrylamide (13i) (E)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)acrylamide (13j) (E)-3-(4-methoxyphenyl)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (13k) (E)-3-(4-aminophenyl)-N-((1-(p-tolyl)-9H-pyrido[3,4-b]indol-3-yl)methyl)acrylamide (13l) 3. N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)

Metadata:
- Claim Count in Document: 1.0
- Percentile: 95.0
- Lexical Diversity: 1.7551
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15504985', '14689742', '13502944', '10326081', '13509442']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8519486852318195
- 35 USC 102 Novelty (BERT): 0.5579331864548771
- Combined Prediction Score: 0.8225471353541254
- Mean Citation Score: 418.263468
- Max Citation Score: 466.71274000000005
- Similarity Product: 341.1205593604744

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test