PATENT CLAIM ANALYSIS

Application Number: 15773976
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "210180"]

Abstract:
The present teachings relate to pyrone derivatives, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections.

Claim (Index 4):
A compound of Formula IX: or a pharmaceutically acceptable salt thereof,\n wherein: \n R 1  is H, C 1-6  alkyl, \u2014OH, \u2014NH 2 , or SH; \n R 2  is H, \u2014OR a , C 1-6  alkyl, or C 1-6  alkoxy; \n R 3  is H, C 1-6  alkyl, \u2014OH, \u2014NH 2 , or SH; \n R 6  and R 7  are each independently, at each occurrence, \u2014OH, \u2014NH 2 , \u2014CN, \u2014NO 2 , \u2014C(\u2550O)OR b , C(\u2550O) N(R b ) 2 , \u2014N(R b )C(\u2550O)OR b , halo, C 1-6  alkyl, C 1-6  alkoxy, or \u2550O; \n ring R is C 3-7  cycloalkyl, C 3-10  heterocycloalkyl, C 6-14  aryl, or a 5- to 14-membered heteroaryl; \n ring T is C 3-7  cycloalkyl, C 3-10  heterocycloalkyl, C 6-14  aryl, or a 5- to 14-membered heteroaryl; \n Z is O or S; \n L 1  is a bivalent radical selected from a bond, \u2014C(\u2550O)\u2014, \u2014(C(\u2550O)O)\u2014, \u2014OC(\u2550O)\u2014, \u2014(C(\u2550O)NR c )\u2014, \u2014N(R c )C(\u2550O)\u2014, \u2014N(R c )\u2014, \u2014S(\u2550O) 2 \u2014, \u2014(C 1-4  alkylene)\u2014, \u2014(C 1-4  alkylene)\u2014O\u2014, \u2014(C 1-4  alkylene)\u2014N(R c )\u2014, \u2014(C 1-4  alkylene)\u2014S\u2014, or \u2014(C 1-4  alkylene)\u2014S(\u2550O) 2 \u2014; \n L 2  is a bivalent radical selected from \u2014(C(R 4 )(R 5 )) n \u2014(C 0-3  alkylene)\u2014, \u2014(C(R 4 )(R 5 )) n \u2014(C 0-3  alkylene)\u2014(C\u2014OR c )\u2014, \u2014(C(R 4 )(R 5 )) n \u2014(C 0-3  alkylene)\u2014C(\u2550O)\u2014, \u2014(C(R 4 )(R 5 )) n \u2014(C 0-3  alkylene)\u2014C(\u2550N\u2014OH)\u2014, \u2014(C(R 4 )(R 5 )) n \u2014(C 0-3  alkylene)\u2014(C(\u2550O)NR 5 )\u2014, \u2014(C(R 4 )(R 5 )) n \u2014(C 0-3  alkylene)\u2014N(R 5 )C(\u2550O)\u2014, \n \u2014(C(R 4 )(R 5 ))\u2014(C 0-3  alkylene)\u2014O\u2014, or 4C(R 4 )(R 5 )) n \u2014(C 0-3  alkylene)\u2014N(R 5 )\u2014;\n wherein each R 4  is H or optionally substituted C 1-6  alkyl; and \n each R 5  is independently H, an optionally substituted C 1-6  alkyl, an optionally substituted C 1-6  alkenyl, an optionally substituted C 1-6  alkynyl, an optionally substituted C 6-14  aryl, an optionally substituted 5- to 14-membered heteroaryl, an optionally substituted C 3 -C 8  cycloalkyl, on optionally substituted \u2014(C 0-4  alkylene)\u2014OR f , \u2014(C 0-4  alkylene)\u2014(C 1-4  alkene), \u2014(C 0-4  alkylene)\u2014(C 1-4  alkyne), C 2 -C 7  heterocycle, \u2014(C 0-4  alkylene)\u2014C(\u2550O)\u2014(C 1 -C 6  alkyl), \u2014(C 0-4  alkylene)\u2014C(\u2550O)H, \u2014(C 0-4  alkylene)\u2014C(\u2550O)OR f , \u2014(C 0-4  alkylene)\u2014CN, \u2014(C 0-4  alkylene)-halo, \u2014(C 0-4  alkylene)\u2014NO 2 , \u2014(C 0-4  alkylene)\u2014N(R f ) 2 , \u2014(C 0-4  alkylene)\u2014S(\u2550O) 2 \u2014(R f ), \u2014(C 0-4  alkylene)\u2014(C 6-14  aryl), \u2014(C 1-4  alkylene)-(5- to 14-membered heteroaryl), \u2014(C 0-4  alkylene)\u2014C(\u2550O)NR b R f  or \u2014(C 0-4  alkylene)\u2014NR b C(\u2550O)R f ; \n wherein each R f  is independently H, an optionally substituted alkyl, an optionally substituted heteroalkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl or an optionally substituted alkoxy; \n L 3  is a bivalent radical selected from a bond, \u2014(C 1-6  alkylene)\u2014, \u2014(C 2-6  alkenylene)\u2014, or \n \u2014(C 2-6  alkynylene)\u2014, \u2014(C 3-10  heterocycloalkylene) \u2014, \u2014(C 6-14  arylene)\u2014, -(5- to 14-membered heteroarylene)-;\n R a  R b , R c , R d , and R e  are each independently, at each occurrence, H or C 1-6  alkyl; \n n is 1 or 2; \n p is 0, 1, 2, or 3; and \n r is 0, 1, 2, or 3, \n provided that R 1  or R 3  is \u2014OH, \u2014NH 2 , or SH.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.09524
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15773975', '14390857', '15531245', '13420988', '15597453']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7656368210432518
- 35 USC 102 Novelty (BERT): 0.5698445025213345
- Combined Prediction Score: 0.7460575891910601
- Mean Citation Score: 333.687084
- Max Citation Score: 491.4048
- Similarity Product: 347.65219132232664

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test