PATENT CLAIM ANALYSIS

Application Number: 16059821
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["800", "018000"]

Abstract:
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

Claim (Index 28):
A method for generating a human heavy or light chain variable domain sequence comprising the steps of:\n (a) immunizing a genetically modified mouse with an antigen, wherein the mouse:\n (i) has a genome that comprises:\n (A) one or more human V H  gene segments, one or more human D H  gene segments, and one or more human J H  gene segments operably linked to a mouse heavy chain constant region at an endogenous mouse immunoglobulin heavy chain locus, \n (B) one or more human V L  gene segments and one or more human J L  gene segments operably linked to a light chain constant region, and \n (C) a nucleotide sequence that encodes a mouse ADAM6 protein, which nucleotide sequence is integrated in the genome of the mouse, wherein the mouse ADAM6 protein is expressed in the genetically modified mouse; \n \n (ii) generates antibodies when immunized with the antigen, wherein the antibodies each comprise a human heavy chain variable domain operably linked to mouse heavy chain constant domain; and \n (iii) is fertile; and \n (b) determining a human heavy or light chain variable domain sequence of an antibody that specifically binds the antigen and that was generated by the genetically modified mouse.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 96.0
- Lexical Diversity: 2.0
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16059871', '16059884', '14192051', '14600829', '14682859']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7538670981868695
- 35 USC 102 Novelty (BERT): 0.7242135945377295
- Combined Prediction Score: 0.7509017478219555
- Mean Citation Score: 853.0736539999997
- Max Citation Score: 879.0234
- Similarity Product: 796.7826690518974

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test