PATENT CLAIM ANALYSIS

Application Number: 16075409
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["544", "316000"]

Abstract:
The present invention provides a compound having TrkA inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I): wherein ═X is ═O or the like, R 5  and R 5A  are hydrogen atoms or the like, -A- is —NR 1 — or the like, B is substituted or unsubstituted aromatic carbocyclyl or the like, R 1  is substituted or unsubstituted alkyl or the like, R 2  is a hydrogen atom or the like, —W— is —CH 2 — or the like, —W A — is —CH 2 — or the like, R 13  is substituted or unsubstituted aromatic carbocyclyl or the like, R 14  is substituted or unsubstituted aromatic heterocyclyl or the like, R 15  is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same.

Claim (Index 1):
A compound represented by Formula (I): wherein \u2550X is \u2550O, \u2550S, \u2550NR 10  or \u2550CR 11 R 12 ; \u2014W\u2014 is \u2014C(R 8 R 9 )n-; \u2014W A \u2014 is \u2014C(R 3 R 4 )m-; n is 0, 1 or 2; m is 1 or 2; n is 0, 1 or 2 when m is 1, and n is 0 when m is 2; -A- is \u2014NR\u2032\u2014 or \u2014CR 1D R 1E \u2014; B is substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy; R 1  is a hydrogen atom, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted acyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, substituted or unsubstituted non-aromatic heterocyclylsulfonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl; R 1D  and R 1E  are each independently a hydrogen atom, hydroxy, halogen, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted acyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted amino, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, substituted or unsubstituted non-aromatic heterocyclylsufonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl; or R 1D  and R 1E  may be taken together to form \u2550CR 1F R 1G , oxo, \u2550N\u2014O\u2014R 1H , a substituted or unsubstituted non-aromatic carbocycle, or a substituted or unsubstituted non-aromatic heterocycle; R 1F  and R 1G  are each independently a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, or substituted or unsubstituted alkyloxycarbonyl; R 1H  is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl; R 2  is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, cyano, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted carbamoyl, halogen, or hydroxy; R 3  is each independently a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxycarbonyl, or substituted or unsubstituted carbamoyl; R 4  is each independently a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl, or R 3  and R 4  may be taken together to form oxo; R 5  and R 5A  are each independently a hydrogen atom, or substituted or unsubstituted alkyl; R 8  is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or substituted or unsubstituted alkyloxy; R 9  is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or substituted or unsubstituted alkyloxy, or R 8  and R 9  may be taken together to form oxo; R 10  is substituted or unsubstituted alkyl, substituted or unsubstituted acyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkylsulfonyl, nitro, substituted or unsubstituted alkyloxy, or hydroxy; R 11  is a hydrogen atom, cyano, substituted or unsubstituted acyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylsulfonyl, or nitro; R 12  is a hydrogen atom or cyano; R 13  is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl; R 14  is a hydrogen atom, hydroxy, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, substituted or unsubstituted non-aromatic heterocyclylsulfonyl, substituted or unsubstituted aromatic carbocyclylcarbonyloxy, substituted or unsubstituted non-aromatic carbocyclylcarbonyloxy, substituted or unsubstituted aromatic heterocyclylcarbonyloxy, substituted or unsubstituted non-aromatic heterocyclylcarbonyloxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl; R 15  is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted alkylsulfanyl, substituted or unsubstituted alkenylsulfanyl, substituted or unsubstituted alkynylsulfanyl, substituted or unsubstituted amino, substituted or unsubstituted carbamoyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl; or R 14  and R 15  may be taken together to form a substituted or unsubstituted non-aromatic carbocycle or a substituted or unsubstituted non-aromatic heterocycle; provided that (\u03b1) when \u2014W\u2014 is \u2014CH 2 \u2014, \u2014W A \u2014 is \u2014CH 2 \u2014, \u2550X is \u2550O, R 5  is a hydrogen atom, R 5A  is a hydrogen atom, and -A- is \u2014NR 1 \u2014, (1) B is a group represented by the following formula: wherein R 16  and R 17  are each independently halogen; or (2) R 14  is substituted or unsubstituted 9- to 10-membered bicyclic aromatic heterocyclyl, substituted or unsubstituted 9- to 10-membered bicyclic non-aromatic heterocyclyl, or a group represented by the following formula: wherein R a  and R b  are each independently a hydrogen atom, cyano, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl; R c  is a hydrogen atom, or substituted or unsubstituted alkyl; R\u2032 is each independently halogen, cyano, hydroxy, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted carbamoyl, or substituted or unsubstituted sulfamoyl; p is 0, 1 or 2; and q is 0, 1, 2 or 3; and (\u03b2) when \u2014W A \u2014 is \u2014CH 2 \u2014C(R 3 R 4 )\u2014, -A- is \u2014NR 1 \u2014, and n is 0, and (\u03b3) when \u2014W A \u2014 is \u2014CH 2 \u2014, \u2014W\u2014 is \u2014CH 2 \u2014, and -A- is \u2014CR 1D R 1E \u2014, (1) B is a group represented by the following formula: wherein R 16  and R 17  are each independently halogen; or (2) R 14  is substituted or unsubstituted 9- to 10-membered bicyclic aromatic heterocyclyl, substituted or unsubstituted 9- to 10-membered bicyclic non-aromatic heterocyclyl, or a group represented by the following formula: wherein R a  and R b  are each independently a hydrogen atom, cyano, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl; R a , is a hydrogen atom, substituted or unsubstituted alkyl (excluding unsubstituted methyl), substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl; R c  is a hydrogen atom, or substituted or unsubstituted alkyl; R d  is a hydrogen atom, or substituted or unsubstituted alkyl; R e  is a hydrogen atom, hydroxy, cyano, halogen, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted amino, substituted or unsubstituted non-aromatic carbocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl; R\u2032 is each independently halogen, cyano, hydroxy, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted carbamoyl, or substituted or unsubstituted sulfamoyl; p is 0, 1 or 2; q is 0, 1, 2 or 3; r is 0, 1, 2, 3 or 4, provided that the following compounds are excluded: or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 96.0
- Lexical Diversity: 2.5873
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15501749', '15741875', '16061155', '14387387', '15557992']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8349852915153607
- 35 USC 102 Novelty (BERT): 0.5934810626876786
- Combined Prediction Score: 0.8108348686325925
- Mean Citation Score: 532.0969520000001
- Max Citation Score: 581.6987
- Similarity Product: 413.09056004655366

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test