PATENT CLAIM ANALYSIS

Application Number: 15963273
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "210160"]

Abstract:
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

Claim (Index 1):
A compound of formula I, or pharmaceutically acceptable derivatives, solvates, salts, hydrates, or stereoisomers thereof, wherein: R 1  is hydrogen, optionally substituted C 1-6  aliphatic, optionally substituted 3-8 membered saturated or partially unsaturated carbocyclic ring, \u2014OR, or halogen; ring Z is pyridine, or pyrimidine; each R 2  is independently \u2014R, halogen, \u2014OR, \u2014SR, \u2014SO 2 R, \u2014SOR, \u2014C(O)R, \u2014CO 2 R, \u2014C(O)N(R) 2 , \u2014NRC(O)R, \u2014NRC(O)N(R) 2 , \u2014NRSO 2 R, or \u2014N(R) 2 ; each R 3  is independently \u2014R, halogen, \u2014OR, \u2014SR, \u2014SO 2 R, \u2014SOR, \u2014C(O)R, \u2014CO 2 R, \u2014C(O)N(R) 2 , \u2014NRC(O)R, \u2014NRC(O)N(R) 2 , \u2014NRSO 2 R, or \u2014N(R) 2 ; ring A is phenyl or a 5-6-membered heteroaryl having 1, 2, or 3 nitrogens; R 4  is \u2014R, halogen, \u2014OR, \u2014SR, \u2014SO 2 R, \u2014SOR, \u2014C(O)R, \u2014CO 2 R, \u2014C(O)N(R) 2 , NRC(O)R, \u2014NRC(O)N(R) 2 , \u2014NRSO 2 R, or \u2014N(R) 2 ; each R 5  is independently \u2014R, halogen, \u2014OR, \u2014SR, \u2014SO 2 R, \u2014SOR, \u2014C(O)R, \u2014CO 2 R, \u2014C(O)N(R) 2 , \u2014NRC(O)R, \u2014NRC(O)N(R) 2 , \u2014NRSO 2 R, or \u2014N(R) 2 ; each R is independently hydrogen, C 1-6  aliphatic, C 3-10  aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or a 6-12 membered spiro, fused, or bridged bicyclic carbocyclic or heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; or two R groups on the same atom are taken together with the atom to which they are attached to form a C 3-10  aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; n is 1 or 2; p is 0, 1, or 2; and q is 0, 1, or 2; wherein the following compounds are excluded: 4-{7-[3-cyano-4-(tetrahydro-pyran-4-yloxy)-phenyl]-furo[3,2-b]pyridin-2-yl}-3-fluoro-N-(2-hydroxy-ethyl)-N-methyl-benzamide; 5-{2-[2-fluoro-4-(piperazine-1-carbonyl)-phenyl]-furo[3,2-b]pyridin-7-yl}-2-(tetrahydro-pyran-4-yloxy)-benzonitrile; 5-{2-[2-fluoro-4-(5-oxo-[1,4]diazepane-1-carbonyl)-phenyl]-furo[3,2-b]pyridin-7-yl}-2-(tetrahydro-pyran-4-yloxy)-benzonitrile; 5-{2-[2-fluoro-4-(4-hydroxy-piperidine-1-carbonyl)-phenyl]-furo[3,2-b]pyridin-7-yl}-2-(tetrahydro-pyran-4-yloxy)-benzonitrile; 5-{2-[2-fluoro-4-(morpholine-4-carbonyl)-phenyl]-furo[3,2-b]pyridin-7-yl}-2-(tetrahydro-pyran-4-yloxy)-benzonitrile; 4-{7-[3-cyano-4-(tetrahydro-pyran-4-yloxy)-phenyl]-furo[3,2-b]pyridin-2-yl}-N-(2-hydroxy-ethyl)-3-methoxy-N-methyl-benzamide; 5-{2-[4-(4-hydroxy-piperidine-1-carbonyl)-2-methoxy-phenyl]-furo[3,2-b]pyridin-7-yl}-2-(tetrahydro-pyran-4-yloxy)-benzonitrile; 4-{7-[3-cyano-4-(tetrahydro-pyran-4-yloxy)-phenyl]-furo[3,2-b]pyridin-2-yl}-3-methoxy-N,N-dimethyl-benzamide; 4-{7-[3-cyano-4-(tetrahydro-pyran-4-yloxy)-phenyl]-furo[3,2-b]pyridin-2-yl}-3-methoxy-N-(S)-piperidin-3-yl-benzamide; and 4-{7-[3-cyano-4-(tetrahydro-pyran-4-yloxy)-phenyl]-furo[3,2-b]pyridin-2-yl}-3-methoxy-N-(R)-piperidin-3-yl-benzamide.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 91.0
- Lexical Diversity: 1.0
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15194780', '14377528', '15166380', '13819166', '14118845']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8244226822488696
- 35 USC 102 Novelty (BERT): 0.5803452040690118
- Combined Prediction Score: 0.8000149344308838
- Mean Citation Score: 391.602242
- Max Citation Score: 477.57416
- Similarity Product: 436.628986810174

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test