PATENT CLAIM ANALYSIS

Application Number: 16149912
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-09
Patent Classification: ["514", "210200"]

Abstract:
The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

Claim (Index 36):
A method of treating systolic dysfunction or diseases with systolic dysfunction, comprising administering to a subject in need thereof an effective amount of a compound having the formula: or a pharmaceutically acceptable salt thereof, wherein Ar 1  is selected from the group consisting of pyridyl, pyridazinyl, oxazolyl, isoxazolyl, 1,2,3-thiadiazolyl, isothiazolyl, and thiazolyl, each of which is optionally substituted with from 1-3 R a ; Ar 2  is selected from the group consisting of phenyl, pyridyl, pryazolyl, and prayazolo[1,5-a]pyridyl, each of which is optionally substituted with from 1-5 R b ; R 1  and R 2  are each independently a member selected from the group consisting of H, F, C 1 -C 4  alkyl, C 1 -C 4  deuteroalkyl, and C 1 -C 4  haloalkyl; or optionally R 1  and R 2  can be combined to form a C 3 - to C 5  carbocyclic ring which is optionally substituted with one or two F; R 3  is a member selected from the group consisting of H, F, OH and C 1 -C 4  alkyl; each R a  is independently selected from the group consisting of halo, CN, hydroxyl, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 1 -C 4  hydroxyalkyl, C 1 -C 4  alkoxy, C 1 -C 4  haloalkoxy, \u2014COR a1 , \u2014CO 2 R a1 , \u2014SO 2 R a1 , \u2014SO 2 NR a1 R a2 , and \u2014CONR a1 R a2 , wherein each R a1  and R a2  is independently selected from the group consisting of H and C 1 -C 4  alkyl or optionally R a1  and R a2  when attached to a nitrogen atom are combined to form a 4- to 6-membered ring; or optionally, two R a  substituents on adjacent ring members are combined to form a 5- or 6-membered ring having 0, 1 or 2 ring members selected from O, N and S; and each R b  is independently selected from the group consisting of halo, CN, hydroxyl, C 1 -C 4  alkyl, C 1 -C 4  deuteroalkyl, C 1 -C 4  haloalkyl, C 1 -C 4  alkoxy, C 1 -C 4  haloalkoxy, C 3 -C 6  cycloalkyl, \u2014NR b1 R b2 , \u2014COR b1 , \u2014CO 2 R b1 , \u2014SO 2 R b1 , \u2014SO 2 NR b1 R b2 , \u2014CONR b1 R b2 , and a 5- or 6-membered heteroaryl which is optionally substituted with C 1 -C 4  alkyl, and wherein each R b1  and R b2  is independently selected from the group consisting of H and C 1 -C 4  alkyl or optionally R b1  and R b2  when attached to a nitrogen atom are combined to form a 4- to 6-membered ring; or optionally, two R b  substituents on adjacent ring members are combined to form a 5- or 6-membered ring having 0, 1 or 2 ring members selected from O, N and S.

Metadata:
- Claim Count in Document: 113.0
- Percentile: 97.0
- Lexical Diversity: 1.25532
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15003662', '14883152', '14309381', '14309414', '15514046']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7597150622472015
- 35 USC 102 Novelty (BERT): 0.525968574887891
- Combined Prediction Score: 0.7363404135112704
- Mean Citation Score: 287.553448
- Max Citation Score: 348.63446
- Similarity Product: 289.72617713587164

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test