PATENT CLAIM ANALYSIS

Application Number: 15772887
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "303000"]

Abstract:
There are provided compounds of formula I, wherein X, Ak, s, A, R 1  and R 2  have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of the JAK family) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

Claim (Index 1):
A compound of formula I, wherein:\n X represents halo; \n Ak represents C 1-6  alkyl optionally substituted by one or more fluorine atoms; \n s represents 1 or 2; \n A represents C or S(\u2550O); \n R 1  and R 2  each independently represents H, C 1-6  alkyl, C 3-7  cycloalkyl, aryl, heteroaryl, or heterocyclyl, which latter five groups are optionally substituted by one or more substitutents selected from halo, cyano, CO 2 H, oxo, NR 3 SO 2 R 4 , \u2014N\u2550S(O)(R 4 ) 2 , S(O) m R 5 , P(O)(R 4 ) 2 , C(O)NR 5 R 6 , S(O) 2 NR 5 R 6 , \u2014(OCH 2 CH 2 ) 0-4 OR 5 , \u2014(CH 2 ) 0-4 \u2014NR 5 R 6 , C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, aryl, heteroaryl or heterocyclyl, which latter seven groups are optionally substituted by one or more substituents selected from halo, cyano, CO 2 H, C 1-4  alkyl, C 1-4  alkoxy, oxo and hydroxy; \n or R 1  and R 2 , together with the N-atom to which they are attached, form a 4- to 7-membered heterocyclic group that is fully saturated or partially unsaturated and which heterocyclic group contains one N atom (the atom to which R 1  and R 2  are attached) and, optionally, one or more further heteroatoms selected from O, S and N, and which heterocyclic group is optionally fused to a benzene or heteroaromatic ring, and which heterocyclic group is optionally substituted by one or more substituents selected from halo, hydroxy, oxo, CO 2 H, NR 3 SO 2 R 4 , S(O) m R 5 , C(O)NR 5 R 6 , \u2014(CH 2 ) 0-4 \u2014NR 5 R 6 , \u2014(OCH 2 CH 2 ) 0-4 OR 5 , C 1-4  alkyl, C 1-4  alkoxy, aryl, heteroaryl, and heterocyclyl, which latter five groups are optionally substituted by one or more substituents selected from halo, cyano, CO 2 H, C 1-4  alkyl, C 1-4  alkoxy, oxo and hydroxy; \n R 3  represents H or C 1-4  alkyl optionally substituted by one or more substituents selected from halo, hydroxy and C 1-2  alkoxy; \n R 4  represents C 1-4  alkyl, C 3-7  cycloalkyl, aryl, heteroaryl or heterocyclyl, which latter five groups are optionally substituted by one or more substituents selected from halo, cyano, CO 2 H, C 1-4  alkyl, oxo, hydroxy and C 1-4  alkoxy; \n R 5  and R 6  each independently represent H, C 1-6  alkyl, C 3-7  cycloalkyl, aryl, heteroaryl, or heterocyclyl, which latter five groups are optionally substituted by one or more substituents selected from halo, cyano, CO 2 H, oxo, hydroxy, C 1-4  alkyl, C 1-4  alkoxy, S(O) p R 7 , C(O)NR a R b  and \u2014(CH 2 ) 0-4 \u2014NR a R b , or \u2014[C(R 6b )(R 6c )CH 2 Z] 1-12 \u2014CH 2 CH 2 \u2014R 6a  or \u2014C(R 6b )(R 6c )\u2014[C 1-5  alkylene]-R 6a ; \n or R 5  and R 6 , together with the N-atom to which they are attached, form a 4- to 7-membered heterocyclic group that is fully saturated or partially unsaturated and which heterocyclic group contains one N atom (the atom to which R 5  and R 6  are attached) and, optionally, one or more further heteroatoms selected from O, S and N, and which heterocyclic group is optionally substituted by one or more substituents selected from halo, hydroxy, oxo, CO 2 H, S(O) p R 7 , C(O)NR a R b , \u2014(CH 2 ) 0-4 \u2014NR a R b , \u2014(OCH 2 CH 2 ) 0-4 OR c , C 1-4  alkyl, C 1-4  alkoxy, aryl, heteroaryl and heterocyclyl, which latter five groups are optionally substituted by one or more substituents selected from halo, cyano, CO 2 H, C 1-4  alkyl, C 1-4  alkoxy, oxo and hydroxy; \n Z represents, independently upon each occurrence, O, C(O)N(R 8 ) or N(R 8 )C(O); \n R 6a  represents OR 7a , \u2014S(O) p R 7 , N(R 7b )R 7c  or CO 2 H; \n R 6b , R 6c  and R 8  independently represent H or methyl; \n R a , R b  and R c  independently represent H or C 1-4  alkyl optionally substituted by one or more substituents selected from halo, hydroxy and \u2014CO 2 H, \n or R a  and R b , together with the N-atom to which they are attached, form a 4- to 7-membered heterocyclic group that is fully saturated, partially unsaturated or fully aromatic and which heterocyclic group contains one N atom (the atom to which R a  and R b  are attached) and, optionally, one or more further heteroatoms selected from O, S and N, and which heterocyclic group is optionally substituted by one or more substituents selected from halo, hydroxy, oxo, CO 2 H, C 1-4  alkyl, C 1-4  alkoxy and C 1-4  hydroxyalkyl; \n R 7  represents C 1-4  alkyl optionally substituted by one or more substituents selected from halo, hydroxy and C 1-4  alkoxy; \n R 7a  to R 7c  independently represent H or C 1-4  alkyl optionally substituted by one or more halo atoms or by \u2014CO 2 H, \n or R 7b  and/or R 7c  represents \u2014[C a  alkylene]-[C b  alkylene]-OR 7d , \n or R 7b  and R 7c  together with the N-atom to which they are attached, form a 4- to 7-membered heterocyclic group that is fully saturated, partially unsaturated or fully aromatic and which heterocyclic group contains one N atom (the atom to which R 7b  and R 7c  are attached) and, optionally, one or more further heteroatoms selected from O, S and N, and which heterocyclic group is optionally substituted by one or more substituents selected from halo, hydroxy, oxo, CO 2 H, C 1-4  alkyl, C 1-4  alkoxy and C 1-4  hydroxyalkyl; \n a and b independently represent an integer selected from 1, 2 and 3, wherein the sum of a and b is 2, 3 or 4; \n R 7d  represents H or C 1-4  alkyl optionally substituted by one or more halo atoms; \n m and p represent, independently upon each occurrence, 0, 1 or 2; \n or a pharmaceutically acceptable salt, solvate or isotopic derivative thereof.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 93.0
- Lexical Diversity: 1.6
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13542153', '14041387', '12824845', '14384508', '15341226']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8273710121694123
- 35 USC 102 Novelty (BERT): 0.5665982367568908
- Combined Prediction Score: 0.8012937346281602
- Mean Citation Score: 417.2993
- Max Citation Score: 453.0432
- Similarity Product: 359.5822419204713

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test