PATENT CLAIM ANALYSIS

Application Number: 16046047
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["435", "006100"]

Abstract:
The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.

Claim (Index 58):
A method for determining the presence or absence of a fetal aneuploidy using a maternal blood sample comprising a mixture of fetal and maternal genomic nucleic acids, the method comprising:\n a. obtaining a test sample comprising a mixture of fetal and maternal genomic nucleic acids from a maternal blood sample; b. selectively amplifying a plurality of target nucleic acids from the test sample and a plurality of target nucleic acids from a reference sample, wherein the target nucleic acids are selected from one or more chromosomes to be tested for aneuploidy, and wherein the reference sample is diploid for the one or more chromosomes to be tested for aneuploidy; c. detecting the amplified target nucleic acids from the test sample and from the reference sample; d. quantifying the detected amplified target nucleic acids from the test sample and from the reference sample; e. analyzing the test sample for the presence or absence of a fetal aneuploidy by comparing the quantity of the detected amplified target nucleic acids obtained from the test sample for the one or more chromosomes tested for aneuploidy to the quantity of the detected amplified target nucleic acids obtained from the reference sample for the one or more chromosomes tested for aneuploidy; and f. generating a report on the presence or absence of aneuploidy in the maternal blood sample.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 95.0
- Lexical Diversity: 1.55814
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14705239', '11763245', '13835926', '13837974', '12230628']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7602584432649055
- 35 USC 102 Novelty (BERT): 0.6793870498711685
- Combined Prediction Score: 0.7521713039255319
- Mean Citation Score: 537.6750679999999
- Max Citation Score: 631.3265
- Similarity Product: 585.3623681730032

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test