PATENT CLAIM ANALYSIS

Application Number: 15748827
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-05
Patent Classification: ["514", "408000"]

Abstract:
The invention relates to new compounds with low cytotoxicity for blocking ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of treating disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders and autoimmune disorders and metabolic disorders.

Claim (Index 1):
A compound having the following Formula (I): wherein R 1  is halogen, alkyl, alkenyl, alkynyl, NH 2 , NO 2 , OH or CN; each R 2  is the same or different, representing H, alkyl, C 2-10  alkenyl, alkynyl, NH 2 , NO 2 , C 1-10  alkyloxy, alkylthio, alkylamino, alkyloxyalkyl, OH or CN, aryl or heterocyclic having 1 to 3 heteroatoms selected from the group consisting of N, O and S; R 3  is H, alkyl, alkenyl, alkynyl, NH 2 , NO 2 , OH or CN; R 4  is H, alkyl, alkenyl, alkynyl, NH 2 , NO 2 , OH or CN, or R 4  together with nitrogen atom attached therefrom and R 5  form a fused bicyclic ring having 0 to 3 heteroatoms selected from O; N and S; R 5  is alkylene-R 6  wherein R 6  is OH, NO 2 , CN, alkyl, alkenyl, alkynyl, NR a R b , cycloalkyl, aryl, heterocyclic ring having 0 to 3 heteroatoms selected from O; N and S or fused heterocyclic ring having 0 to 3 heteroatoms selected from O, N and S, each of cycloalkyl, aryl, heterocyclic ring and fused hetercyclic ring is unsubstituted or substituted with one to three of OH; halogen; NH 2 ; NO 2 , CN, alkyl; alkenyl; alkynyl; alkyloxy; heteroaryl having 1 to 3 heteroatoms selected from the group consisting of N, O and S, unsubstituted or substituted with alkyl, alkenyl, alkynyl, OH, halogen, CN, NH 2  or NO 2 ; and R a  and R b  are the same or different, independently representing H; OH; alkyl; alkenyl; alkynyl; alkyloxy; cycloalkyl; heterocyclyl; alkyleneamino; alkylene-N-(alkyl) 2 ; aryl unsubstituted or substituted with OH, halogen, CN, NH 2 , NO 2 , alkyl, alkenyl, alkynyl, alkyloxy or heteroaryl; heteroaryl unsubstituted or substituted with OH, halogen, CN, NH 2 , NO 2 , alkyl, alkenyl, alkynyl or alkyloxy; alkylene-heteroaryl; or alkylene-heterocyclyl unsubstituted or substituted with alkyl; X is \u2014C(O), \u2014S(O) 2  or \u2014NH\u2014C(O)\u2014; m is an integer of 0-3; and n is an integer of 0-7; or a tautomer or stereoisomer thereof, or a solvate, prodrug or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 86.0
- Lexical Diversity: 1.36111
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15746964', '14417477', '14524204', '14654296', '12920050']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7532933748768583
- 35 USC 102 Novelty (BERT): 0.5023659529201229
- Combined Prediction Score: 0.7282006326811848
- Mean Citation Score: 250.257446
- Max Citation Score: 272.47165
- Similarity Product: 234.9118264851957

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test