PATENT CLAIM ANALYSIS

Application Number: 15881919
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "001300"]

Abstract:
This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.

Claim (Index 45):
The compound according to  claim 44  wherein R 3  is:\n \u2014OC(\u2550O)\u2014R 22 \u2014R 20 -PEG, \n wherein: \n R 22  is a divalent spacer comprising one or more of the following moieties (e.g., comprise 1, 2, 3, 4, or 5 of the following moieties; e.g., comprise 1, 2, or 3 of the following moieties; e.g., consist of 1, 2, 3, 4, or 5 of the following moieties; e.g., consist of 1, 2, or 3 of the following moieties): heteroatom (e.g., N, O, or S), alkylene chain, heteroalkylene chain, polyheteroalkylene chain, alkenylene chain, arylene including 6-10 ring atoms, heteroarylene including from 5-10 ring atoms, heterocycloalkylene including 3-9 ring atoms, \u2014OC(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014NHC(\u2550O)\u2014, \u2014C(\u2550O)NH\u2014, \u2014N(C1-6 alkyl)C(\u2550O), \u2014C(\u2550O)N(C 1-6  alkyl)-, \u2014C(\u2550O)\u2014, \u2014NHC(\u2550O)NH\u2014, cyclodextrin, human serum albumin, amino acid, amino acid mimetic, or hydrazine, wherein arylene including 6-10 ring atoms, heteroarylene including from 5-10 ring atoms, and heterocycloalkylene including 3-9 ring atoms are each optionally substituted with 1, 2, or 3 substituents each independently selected from the group consisting of halo, cyano, nitro, hydroxyl, C 1-6  alkoxy, heteroalkyl, C 6-10  aryloxy, C 7-12  aralkoxy, CF 3 , quaternary ammonium ion, sugar, C 1-6  alkyl, \u2014C(\u2550O)(C 1-6  alkyl), \u2014SO 2 (C 1-6  alkyl), \u2014C(\u2550O)O(C 1-6  alkyl), \u2014C(\u2550O)O(heteroalkyl), \u2014C(\u2550O)NH(C 1-6  alkyl), \u2014C(\u2550O)NH(heteroalkyl), \u2014C(\u2550O)(phenyl), \u2014SO 2 (phenyl), and phosphate (or a salt thereof); \n R 20  is \n R S5  is H, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxyC 1-6 alkyl, C 6-10 aryl, or C 7-12  aralkyl, each of which is optionally substituted with a group selected from amide, amine, carboxylic acid or a pharmaceutically acceptable salt thereof, carboxyl ester, thiol, and thioether.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 86.0
- Lexical Diversity: 1.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13938160', '14041953', '15065347', '15602823', '15651687']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7838471840074269
- 35 USC 102 Novelty (BERT): 0.6707158251608321
- Combined Prediction Score: 0.7725340481227675
- Mean Citation Score: 569.07662
- Max Citation Score: 793.8515
- Similarity Product: 616.1254986015558

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test