PATENT CLAIM ANALYSIS

Application Number: 15765844
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "277000"]

Abstract:
The present invention provides a novel medicament for preventing or inhibiting acute kidney injury, the medicament comprising, as an active ingredient, an angiotensin II receptor type 2 agonist or a pharmacologically acceptable salt thereof, and being used for treatment or prevention of acute kidney injury. Also, the present invention provides a novel method for preventing or inhibiting acute kidney injury, the method comprising administering, to a patient, an effective amount of an angiotensin II receptor type 2 agonist or a pharmacologically acceptable salt thereof in combination with an anticancer agent and/or an antitumor agent.

Claim (Index 29):
The method according to  claim 24 , wherein said angiotensin II receptor type 2 agonist or a pharmacologically acceptable salt thereof is a sulfonyl malonamide derivative selected from:\n N,N-diethyl-2-{4-[(2,6-difluorobenzoyl)amino]benzyl}-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-2-[4-(benzoylamino)benzyl]-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-N,N-diethyl-2-{4-[(2-fluorobenzoyl)amino]benzyl}-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-N,N-diethyl-2-{4-[(3-fluorobenzoyl)amino]benzyl}-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-N,N-diethyl-2-{4-[(2,4-difluorobenzoyl)amino]benzyl}-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-N,N-diethyl-2-{4-[(4-methylbenzoyl)amino]benzyl}-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)-2-{4-[(2-thieno yl)amino]benzyl}malonamide, (2S)-N,N-diethyl-2-{4-[(2-furoyl)amino]benzyl}-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-2-{4-[(2-amino-5-fluorobenzoyl)amino]benzyl}-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-2-{4-[(2-amino-6-fluorobenzoyl)amino]benzyl}-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)-2-{4-[(2-pyridylcarbonyl)amino]benzyl}malonamide, (2S)-2-{4-[(2-amino-4-chlorobenzoyl)amino]benzyl}-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-2-{4-[(2-aminobenzoyl)amino]benzyl}-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-2-{4-[(2-amino-5-chlorobenzoyl)amino]benzyl}-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-2-{4-[(2-amino-4,5-difluorobenzoyl)amino]benzyl}-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-2-{4-[(2-amino-4-fluorobenzoyl)amino]benzyl}-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)malonamide, (2S)-2-{4-[(2-amino-5-methylbenzoyl)amino]benzyl}-N,N-diethyl-N\u2032-(2-naphthylsulfonyl)malonamide, 2-(4-fluorobenzyl)-N-isopropyl-N-(3-pyridyl)-N\u2032-((E)-styrylsulfonyl)malonamide, 2-allyl-N-(4-fluorophenyl)-N-isopropyl-N\u2032-((E)-styrylsulfonyl)malonamide, N-(4-fluorophenyl)-2-isobutyl-N-isopropyl-N\u2032-((E)-styrylsulfonyl)malonamide, N-(4-fluorophenyl)-2-isobutyl-N-isopropyl-N\u2032-phenethylsulfonyl malonamide, N-(4-fluorophenyl)-2-isobutyl-N-isopropyl-N\u2032-(2-naphthylsulfonyl)malonamide, (2S or 2R)-2-cyclopropylmethyl-N-(4-fluorophenyl)-N-isopropyl-N\u2032-((E)-2-styrylsulfonyl)malonamide, 2-cyclopropylmethyl-N-(4-fluorophenyl)-N-isopropyl-N\u2032-phenethylsulfonyl malonamide, or 2-cyclopropylmethyl-N-(4-fluorophenyl)-N-isopropyl-N\u2032-(2-naphthylsulfonyl)malonamide, or a pharmacologically acceptable salt thereof.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 91.0
- Lexical Diversity: 2.0
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15301438', '12665537', '13234514', '14433149', '09974004']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7759813954527647
- 35 USC 102 Novelty (BERT): 0.6163470558802043
- Combined Prediction Score: 0.7600179614955086
- Mean Citation Score: 317.665034
- Max Citation Score: 590.0824
- Similarity Product: 490.2181220640183

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test