PATENT CLAIM ANALYSIS

Application Number: 15885147
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "419000"]

Abstract:
The disclosure provides methods of treating a condition, disease, or disorder in a subject that involves metabolically reprogrammed cells whose activation, function, growth, proliferation, or survival depends on increased activity of at least one metabolic pathway selected from the group consisting of glutamine metabolism, glycolysis, and fatty acid synthesis, comprising administering to the subject a compound having formula (I): and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 2 ′, and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON).

Claim (Index 1):
A method for treating a condition, disease, or disorder in a subject that involves:\n (i) metabolically reprogrammed cells whose activation, function, growth, proliferation, or survival depends on increased activity of at least one metabolic pathway selected from the group consisting of glutamine metabolism, glycolysis, and fatty acid synthesis; and (ii) at least one of:\n (a) aberrant glutamine metabolism; \n (b) aberrant glycolysis; or \n (c) aberrant fatty acid synthesis, \n the method comprising administering to the subject in need thereof a compound having formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n X is selected from the group consisting of a bond, \u2014O\u2014, and \u2014(CH 2 ) n \u2014, wherein n is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, and 8; \n R 1  is selected from the group consisting of C 1-6  alkyl and substituted C 1-6  alkyl; \n R 2  is an amino acid, an N-substituted amino acid, or \u2014C(\u2550O)\u2014O\u2014(CR 3 R 4 ) m \u2014O\u2014C(\u2550O)\u2014R 10 ; \n R 2 \u2032 is selected from the group consisting of H, C 1 -C 6  alkyl, and substituted C 1 -C 6  alkyl; \n each R 3  and R 4  are independently H C 1 -C 6  alkyl substituted C 1 -C 6  alkyl, aryl, substituted aryl, \u2014(CR 3 R 4 ) m \u2014NR 5 R 6 , or \n m is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, and 8; R 5  and R 6  are independently H or alkyl; and R 10  is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, monosaccharide, acylated monosaccharide, aryl, substituted aryl, heteroaryl, and substituted heteroaryl.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 86.0
- Lexical Diversity: 1.5125
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15885258', '15263033', '15612877', '15502105', '15314959']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7511696957750386
- 35 USC 102 Novelty (BERT): 0.5198646213676124
- Combined Prediction Score: 0.728039188334296
- Mean Citation Score: 261.962262
- Max Citation Score: 302.14194
- Similarity Product: 187.2145471437907

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test