PATENT CLAIM ANALYSIS

Application Number: 15977258
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["506", "002000"]

Abstract:
Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject. TCR and/or IG sequence diversity and sequence distribution permit immunocompetence and immune repertoire assessment and reflect the degree of T cell or B cell clonality and clonal expansion in the sample. Methods for stratifying patient populations on the basis of immunocompetence including likelihood of responding to immunotherapy are also described.

Claim (Index 17):
A method of categorizing a subject as likely to benefit from immunotherapy of a cancer by an inhibitor of CTLA-4, the method comprising the steps of:\n (a) generating a first profile of adaptive immune receptor (AIR) nucleic acid sequence distribution from a first sample obtained from the subject prior to administration of the immunotherapy, wherein said first sample comprises lymphoid nucleic acids; (b) generating a second profile of AIR nucleic acid sequence distribution from a second sample obtained from the subject during or after administration of the immunotherapy, wherein said second sample comprises lymphoid nucleic acids; (c) quantifying an AIR sequence distribution score for each sample by calculating a frequency of occurrence of a plurality of unique rearranged AIR nucleic acid sequences in each sample as a percentage of the total number of rearranged AIR nucleic acid sequences; (d) categorizing the subject as likely to benefit from the immunotherapy if the AIR sequence distribution score of the second sample is higher than the AIR sequence distribution value of the first sample.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 93.0
- Lexical Diversity: 1.50725
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15637871', '13708847', '14199167', '13656265', '14471821']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4612725665699447
- 35 USC 102 Novelty (BERT): 0.6394773756289813
- Combined Prediction Score: 0.4790930474758483
- Mean Citation Score: 395.108366
- Max Citation Score: 693.2953
- Similarity Product: 543.1451826107143

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test