PATENT CLAIM ANALYSIS

Application Number: 16125028
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2018-12
Patent Classification: ["424", "139100"]

Abstract:
The present invention provides isolated monoclonal antibodies that specifically bind LAG-3, and have optimized functional properties compared to previously described anti-LAG-3 antibodies, such as antibody 25F7 (US 2011/0150892 A1). These properties include reduced deamidation sites, while still retaining high affinity binding to human LAG-3, and physical (i.e., thermal and chemical) stability. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided, as well as immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies. The present invention also provides methods for detecting LAG-3, as well as methods for treating stimulating immune responses using an anti-LAG-3 antibody of the invention. Combination therapy, in which the antibodies are co-administered with at least one additional immunostimulatory antibody, is also provided.

Claim (Index 67):
A method of treating cancer in a subject in need thereof comprising administering to the subject a full-length IgG4 human monoclonal antibody that binds human LAG-3, wherein the heavy chain comprises the amino acid sequence of SEQ ID NO: 35 and the light chain comprises the amino acid sequence of SEQ ID NO: 37.

Metadata:
- Claim Count in Document: 83.0
- Percentile: 97.0
- Lexical Diversity: 1.68889
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15296290', '14093867', '15369290', '14227733', '15730363']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7368294521131711
- 35 USC 102 Novelty (BERT): 0.6316178791462147
- Combined Prediction Score: 0.7263082948164754
- Mean Citation Score: 541.614424
- Max Citation Score: 624.8985
- Similarity Product: 527.1770602226258

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test