PATENT CLAIM ANALYSIS

Application Number: 15758274
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "233200"]

Abstract:
The present invention provides methods for inhibiting Fyn kinase, using 5-3-pyridin-2-amine, 6-3-imidazo[1,2-a] pyrazine, 6-3-imidazo[1,2-b] pyridazine, N-(5-imidazo [2,1-b][1,3,4] thiadiazol-2-yl)-amine, 4-3-1H-pyrazolo[3,4-b] pyridine, and N-(3-imidazo [1,2-b] pyridazin-6-yl) amine compounds and methods of treatment, prevention, inhibition or amelioration of diseases and conditions associated with Fyn kinase using such compounds.

Claim (Index 9):
A compound of formula (III) selected from the group consisting of N-[4-[3-(4-hydroxy-3-methoxy-phenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, N-[3-[6-(1,3-benzodioxol-5-yl)imidazo[,2-b]pyridazin-3-yl]phenyl]acetamide, N-[3-[3-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, N-[3-[6-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 1-[3-[6-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, N-[3-[6-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-[3-[3-(3-acetamidophenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, N-[3-[3-(3-acetylphenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl] acetamide, 4-[3-(3-acetamidophenyl)imidazo[1,2-b]pyridazin-6-yl]benzamide, N-[4-[3-(3-hydroxyphenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, N-[3-[3-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, N-[3-[6-(4-dimethylaminophenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-[3-[3-(4-hydroxy-3-methoxy-phenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, N-[3-[3-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl]methanesulfonamide, 1-[3-[6-(3-hydroxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, [4-[3-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl]methanol, 4-[3-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]benzamide, N-(2-dimethylaminoethyl)-3-[6-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]benzamide, 3-[3-(3-hydroxyphenyl)imidazo[1,2-b]pyridazin-6-yl]benzamide, 4-[3-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenol, [3-[6-(3-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, [3-[6-[(4-fluorophenyl)methyl]imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, [3-[6-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, N-[3-[3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanesulfonamide, 6-(2-methoxyphenyl)-3-(4-pyridyl)imidazo[1,2-b]pyridazine, 3-[3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-yl]benzamide, N-[3-(6-phenylimidazo[1,2-b]pyridazin-3-yl)phenyl] acetamide, N-[3-[6-(3-hydroxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-(3,4-dimethoxyphenyl)-6-(3-fluorophenyl)imidazo[1,2-b]pyridazine, N-[3-[6-[4-(hydroxymethyl)phenyl] imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, [3-(6-phenylimidazo[1,2-b]pyridazin-3-yl)phenyl]methanol, 6-(3-chlorophenyl)-3-(4-pyridyl)imidazo[1,2-b]pyridazine, 4-[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenol, N-[3-[6-(2-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-[3-[6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenyl] acetamide, [3-[6-(2-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 4-[3-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenol, 3-phenyl-6-(4-pyridyl)imidazo[1,2-b]pyridazine, 3-[3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-yl]phenol, 3-(3,4-dimethoxyphenyl)-6-phenyl-imidazo[1,2-b]pyridazine, 3-(3,4-dimethoxyphenyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine, N-[3-[6-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-[3-[6-(4-hydroxy-3-methoxy-phenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-phenyl-6-(3-pyridyl)imidazo[1,2-b]pyridazine, [4-[3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanol, 3-(3,4-dimethoxyphenyl)-6-(2-methoxyphenyl)imidazo[1,2-b]pyridazine, 3-(3,4-dimethoxyphenyl)-6-(3-furyl)imidazo[1,2-b]pyridazine, N-[3-[6-(3-furyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, [3-[6-(3-furyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, N,N-dimethyl-4-[3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-yl]aniline, [3-[6-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, N-[3-(3-phenylimidazo[1,2-b]pyridazin-6-yl)phenyl]acetamide, 6-phenyl-3-(4-pyridyl)imidazo[1,2-b]pyridazine, 6-(3-fluorophenyl)-3-(4-pyridyl)imidazo[1,2-b]pyridazine, 3-(3,4-dimethoxyphenyl)-6-(3-methoxyphenyl)imidazo[1,2-b]pyridazine, N-[3-[6-(5-methoxy-3-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, [3-[6-(5-methoxy-3-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 6-(1,3-benzodioxol-5-yl)-3-(4-pyridyl)imidazo[1,2-b]pyridazine, 6-(3-furyl)-3-(4-pyridyl)imidazo[,2-b]pyridazine, N-[3-[6-(3-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, N-[3-[6-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-[3-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenol, 4-(3-phenylimidazo[1,2-b]pyridazin-6-yl)benzamide, 3-[3-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-6-yl]phenol, 6-phenyl-3-(3-pyridyl)imidazo[1,2-b]pyridazine, 3-(3-pyridyl)-6-(2-thienyl)imidazo[1,2-b]pyridazine, N-[3-[6-(3-acetylphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl] acetamide, 3-[6-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 4-[6-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 1-[3-[6-(2-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl] ethanone, 1-[3-[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, N-[3-[3-(2-thienyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanesulfonamide, 3-(1,3-benzodioxol-5-yl)-6-(3-pyridyl)imidazo[1,2-b]pyridazine, [4-[3-(3-pyridyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanol, 6-benzyl-3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazine, 3-[6-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenol, [4-[6-(2-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl] methanol, [4-[6-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 2-methoxy-4-[6-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 1-[3-[6-(3-furyl)imidazo[1,2-b]pyridazin-3-yl]phenyl] ethanone, 4-[3-(2-thienyl)imidazo[1,2-b]pyridazin-6-yl]benzamide, 3-[3-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-6-yl]-N-(2-hydroxyethyl)benzamide, [3-[3-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-6-yl]phenyl] methanol, N-[3-[6-(2-thienyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-(6-phenylimidazo[1,2-b]pyridazin-3-yl)phenol, 1-[3-[3-(3-hydroxyphenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl] ethanone, [4-[6-(3-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 1-[3-[3-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl]ethanone, 1-[3-[6-[3-(dimethylamino)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 1-[3-[6-(6-amino-3-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, [4-[3-(2-thienyl)imidazo[1,2-b]pyridazin-6-yl]phenyl] methanol, N-[3-[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanesulfonamide, 3-[3-(3-acetylphenyl)imidazo[1,2-b]pyridazin-6-yl]benzamide, N-[3-[3-(3-pyridyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanesulfonamide, 3-[6-(4-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-[6-(5-quinolyl)imidazo[1,2-b]pyridazin-3-yl]phenol, N-[3-[3-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl]methanesulfonamide, 2-methoxy-4-[6-(2-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-[3-(3-acetylphenyl)imidazo[1,2-b]pyridazin-6-yl]-N-methyl-benzamide, [3-[3-(2-thienyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanol, 6-(1-methylpyrazol-4-yl)-3-(2-thienyl)imidazo[1,2-b]pyridazine, 3-[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]-N-(2-hydroxyethyl)benzamide, 3-(1,3-benzodioxol-5-yl)-6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazine, 3-(3,4-dimethoxyphenyl)-6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazine, 3-[6-(3-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 1-[3-[6-(3-aminophenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 6-(2-methoxyphenyl)-3-(3-pyridyl)imidazo[1,2-b]pyridazine, 3-(3,4-dimethoxyphenyl)-6-(4-pyridyl)imidazo[1,2-b]pyridazine, 3-[6-(3-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenol, [4-[6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 4-[6-(3-hydroxyphenyl)imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 6-(3,4-dimethoxyphenyl)-3-(4-pyridyl)imidazo[1,2-b]pyridazine, 6-(4-fluorophenyl)-3-(3-pyridyl)imidazo[1,2-b]pyridazine, [3-[3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanol, 3-[6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-phenyl-6-(2-thienyl)imidazo[1,2-b]pyridazine, 3-(3,4-dimethoxyphenyl)-6-(3-pyridyl)imidazo[1,2-b]pyridazine, N-[3-[3-(3-hydroxyphenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, 4-[6-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 3-[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]-N-methyl-benzamide, N-[3-[3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-yl]phenyl] acetamide, 6-(3-furyl)-3-(3-pyridyl)imidazo[1,2-b]pyridazine, N-[3-[6-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-[6-(3-furyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 1-[3-[6-(4-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 6-(m-tolylmethyl)-3-(4-pyridyl)imidazo[1,2-b]pyridazine, 3-(1,3-benzodioxol-5-yl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine, 3,6-bis(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazine, 3-[6-(2-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenol, [4-(6-phenylimidazo[1,2-b]pyridazin-3-yl)phenyl] methanol, N-[4-[3-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, 4-[6-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 1-[3-[6-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 6-(4-pyridyl)-3-(2-thienyl)imidazo[1,2-b]pyridazine, 2-methoxy-4-[3-(2-thienyl)imidazo[1,2-b]pyridazin-6-yl]phenol, N-(2-hydroxyethyl)-3-(3-phenylimidazo[1,2-b]pyridazin-6-yl)benzamide, 6-benzyl-3-(4-pyridyl)imidazo[1,2-b]pyridazine, 4-[3-(3-pyridyl)imidazo[1,2-b]pyridazin-6-yl]benzamide, 1-[3-[6-(3-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl] ethanone, 1-[3-[6-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 6-[(4-fluorophenyl)methyl]-3-(4-pyridyl)imidazo[1,2-b]pyridazine, 3-[3-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-6-yl]aniline, 3-(1,3-benzodioxol-5-yl)-6-(3-furyl)imidazo[1,2-b]pyridazine, [4-[6-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 3-[3-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-6-yl]-N-(2-dimethylaminoethyl)benzamide, N-[3-[6-(3-chloro-4-fluoro-phenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-[3-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenol, [3-[6-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 1-[3-[3-(3-acetylphenyl)imidazo[1,2-b]pyridazin-6-yl]phenyl] ethanone, N-(2-dimethylaminoethyl)-3-[3-(2-thienyl)imidazo[1,2-b]pyridazin-6-yl]benzamide, 3-(1,3-benzodioxol-5-yl)-6-phenyl-imidazo[1,2-b]pyridazine, 3-[3-(3-pyridyl)imidazo[1,2-b]pyridazin-6-yl]phenol, 3-(3,4-dimethoxyphenyl)-6-(2-thienyl)imidazo[1,2-b]pyridazine, 3-[3-(3-hydroxyphenyl)imidazo[1,2-b]pyridazin-6-yl]phenol, N-[3-[3-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl]acetamide, 1-[3-[6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 3-[3-(3-acetamidophenyl)imidazo[1,2-b]pyridazin-6-yl]-N-methyl-benzamide, [3-(3-phenylimidazo[1,2-b]pyridazin-6-yl)phenyl]methanol, 6-(1-methylpyrazol-4-yl)-3-(4-pyridyl)imidazo[1,2-b]pyridazine, N-(2-dimethylaminoethyl)-3-[3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-yl]benzamide, [4-[3-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]phenyl]methanol, 4-[6-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 1-[3-[6-(2-thienyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 6-(5-methoxy-3-pyridyl)-3-(2-thienyl)imidazo[1,2-b]pyridazine, 3,6-bis(2-thienyl)imidazo[1,2-b]pyridazine, N-(2-dimethylaminoethyl)-3-[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]benzamide, 3-[6-(1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-3-yl]-N-(2-dimethylaminoethyl)benzamide, 3-[3-[3-(2-dimethylaminoethylcarbamoyl)phenyl] imidazo[1,2-b]pyridazin-6-yl]benzamide, N-(2-hydroxyethyl)-3-[3-(3-hydroxyphenyl)imidazo[1,2-b]pyridazin-6-yl]benzamide, 2-methoxy-4-[6-(3,4,5-trimethoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]phenol, [3-[3-(3-furyl)imidazo[1,2-b]pyridazin-6-yl]phenyl]methanol, 4-(6-benzylimidazo[1,2-b]pyridazin-3-yl)benzamide, 3-[6-(4-acetamidophenyl)imidazo[1,2-b]pyridazin-3-yl]-N-(2-dimethylaminoethyl)benzamide, 2-methoxy-4-[6-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenol, N-(2-dimethylaminoethyl)-3-[6-[3-(hydroxymethyl)phenyl] imidazo[1,2-b]pyridazin-3-yl]benzamide, 4-[6-[(3,4-difluorophenyl)methyl]imidazo[1,2-b]pyridazin-3-yl]benzamide, 3-[6-(3-acetamidophenyl)imidazo[1,2-b]pyridazin-3-yl]-N-(2-dimethylaminoethyl)benzamide, 2-methoxy-4-[6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenol, 6-benzyl-3-(5-methoxy-3-pyridyl)imidazo[1,2-b]pyridazine, 4-[6-(m-tolylmethyl)imidazo[1,2-b]pyridazin-3-yl]benzamide, N-(2-dimethylaminoethyl)-3-[6-(2-methoxyphenyl)imidazo[1,2-b]pyridazin-3-yl]benzamide, N-(2-dimethylaminoethyl)-3-[6-(3-phenoxyphenyl)imidazo[1,2-b] pyridazin-3-yl] benzamide, 3-(6-cyclopropylimidazo[1,2-b]pyridazin-3-yl)phenol, 4-[6-(3-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 6-[(4-fluorophenyl)methyl]-3-(5-methoxy-3-pyridyl)imidazo[1,2-b]pyridazine, 4-[6-[(4-fluorophenyl)methyl]imidazo[1,2-b]pyridazin-3-yl]benzamide, N-(2-hydroxyethyl)-3-[3-[4-(hydroxymethyl)phenyl] imidazo[1,2-b]pyridazin-6-yl]benzamide, 3-[3-(4-hydroxy-3-methoxy-phenyl)imidazo[1,2-b]pyridazin-6-yl]benzamide, 3-(1-methylpyrazol-4-yl)-6-(m-tolylmethyl)imidazo[1,2-b]pyridazine, 3-[3-(3-acetylphenyl)imidazo[1,2-b]pyridazin-6-yl]-N-(2-hydroxyethyl)benzamide, [4-(6-benzylimidazo[1,2-b]pyridazin-3-yl)phenyl]methanol, 4-[6-[(4-fluorophenyl)methyl]imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, -[(4-fluorophenyl)methyl]-3-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazine, N-(2-dimethylaminoethyl)-3-[6-(4-fluorophenyl)imidazo[1,2-b]pyridazin-3-yl]benzamide, 3-[3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl]-N-(2-hydroxyethyl)benzamide, 3-[6-(m-tolylmethyl)imidazo[1,2-b]pyridazin-3-yl]benzamide, 1-[3-(6-benzylimidazo[1,2-b]pyridazin-3-yl)phenyl] ethanone, 5-(6-benzylimidazo[1,2-b]pyridazin-3-yl)pyridin-2-amine, N-(2-dimethylaminoethyl)-3-[6-(3-furyl)imidazo[1,2-b]pyridazin-3-yl]benzamide, 3-[3-[4-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]-N-methyl-benzamide, 2-methoxy-4-[6-(propylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-(4-pyridyl)-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, 2-methoxy-4-[6-(tetrahydropyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, 2-methoxy-4-[6-(2-thienylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, N-propyl-3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-amine, 2-methoxy-4-[6-(2-pyridylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-(4-pyridyl)-N-tetrahydropyran-4-yl-imidazo[1,2-b]pyridazin-6-amine, 3-(3,4-dimethoxyphenyl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine, 4-[6-[[(1S)-1-(hydroxymethyl)-2-methyl-propyl]amino] imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 3-(3,4-dimethoxyphenyl)-N-(2-pyridylmethyl)imidazo[1,2-b]pyridazin-6-amine, 3-[[3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-yl]amino]propan-1-ol, (2S)-3-methyl-2-[[3-(4-pyridyl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, 1-[3-[6-(3-hydroxypropylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]ethanone, 3-(3,4-dimethoxyphenyl)-N-(2-thienylmethyl)imidazo[1,2-b]pyridazin-6-amine, 3-[[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]propan-1-ol, N-[3-[6-(4-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 4-[6-(1,3-benzodioxol-5-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-2-methoxy-phenol, 1-[3-[6-(1,3-benzodioxol-5-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl] ethanone, N-(1,3-benzodioxol-5-ylmethyl)-3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-amine, [3-[6-(4-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol, 2-methoxy-4-[6-(4-pyridyl)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-(4-pyridyl)-N-(2-pyridylmethyl)imidazo[1,2-b]pyridazin-6-amine, 4-[3-(4-hydroxy-3-methoxy-phenyl)imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenol, [3-[3-[3-(hydroxymethyl)phenyl] imidazo[1,2-b]pyridazin-6-yl]phenyl]methanol, N-[3-[6-[3-(hydroxymethyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-(4-fluorophenyl)-N-methyl-imidazo[1,2-b]pyridazin-6-amine, 3-(4-methoxyphenyl)-N-methyl-imidazo[11,2-b]pyridazin-6-amine, 2-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, N-methyl-3-(3-thienyl)imidazo[1,2-b]pyridazin-6-amine, 3-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]phenol, 3-(3,4-dimethoxyphenyl)-N-methyl-imidazo[1,2-b]pyridazin-6-amine, N,N-dimethyl-3-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide, N-methyl-3-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-6-amine, N-[3-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl]acetamide, 3-(6-methoxy-3-pyridyl)-N-methyl-imidazo[1,2-b]pyridazin-6-amine, and (Z)-5-[6-(methylamino)imidazo[1,2-b]pyridazin-3-yl]pent-4-en-1-ol.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.6383
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13056331', '13057325', '12598882', '13049225', '14554714']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8306848655460222
- 35 USC 102 Novelty (BERT): 0.5336848863538792
- Combined Prediction Score: 0.8009848676268079
- Mean Citation Score: 353.30427799999984
- Max Citation Score: 374.5595
- Similarity Product: 306.65785170271994

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test