PATENT CLAIM ANALYSIS

Application Number: 15761350
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["562", "010000"]

Abstract:
Disclosed are novel branched amphiphilic lipids, in particular novel branched amphiphilic lipids of general formula (II). Also disclosed is a method of synthesis for the compounds of formula (II), from unsaturated amphiphilic compounds of general formula (I). Further disclosed is the use of the compounds of general formula (II) and of the lipoplexes obtained by formulation of the compounds of general formula (II) for applications, particularly transfection, in which improved fusion properties are desired.

Claim (Index 17):
Amphiphilic compound of general formula (II): wherein: L 1  and L 2  are each independently a linker; L 3  is a linker; Z is a polar functional group, said group being cationic, anionic, zwitterionic or neutral; a is 0 or 1; n, n\u2032, q and q\u2032 are each independently an integer from 1 to 15; m, m\u2032, p and p\u2032 are each independently an integer from 0 to 4 with the condition that:\n at least one of m and p is different from 0; and \n at least one of m\u2032 and p\u2032 is different from 0; \n R 1  and R 2  are one a hydrogen and the other a thioether group of formula \u2014S-L 4 -R 5  and R 3  and R 4  are one a hydrogen and the other a thioether group of formula \u2014S-L 4 -R 5  such that:\n L 4  is a linker; and \n R 5  is a hydrogen atom, or: \n polar group chosen from the group of organic salts of the ammonium, phosphonium, and imidazolium type and protonable neutral heterocycles; \n a reactive group chosen from the group comprising the group N 3 , amino, alkylamino, COOH, amide, maleimide, alkyne, SH, OH, ester, activated ester, activated carboxylic acid, halo, nitro, nitrile, isonitrile, acrylamide, aldehyde, ketone, acetals, ketals, anhydride, thiocyanate, isothiocyanate, isocyanate, hydrazine, hydrazides, hydrazones, ethers, oxides, cyanates, diazo, diazonium, sulphides, disulphides, sulphoxides, sulphones, sulphonic acids, sulphinic acids, sulphates, sulphenic acids, amidines, imides, imines, imidates, nitrones, hydroxylamines, oximes, hydroxamic acids, thiohydroxamic acids, allenes, ortho esters, sulphites, enamines, ynamines, ureas, pseudo-ureas, semicarbazides, carbodiimides, and carbamates; or \n a bioactive group selected from prodrugs, amino acids, peptides, proteins, antibodies, enzymes, polysaccharides, nucleosides, nucleotides, oligonucleotides, fluorophores, chromophores, radioisotopes, carboranes and combinations thereof; \n provided that when a is equal to 0 then Z is different from \u2014S\u2014CH 2 \u2014CH 2 \u2014OH and from \u2014C(O)OMe.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 2.11628
- Patent Class: 562.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13832477', '15037941', '10514523', '12179648', '13387934']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6992306531475412
- 35 USC 102 Novelty (BERT): 0.507424941780068
- Combined Prediction Score: 0.6800500820107939
- Mean Citation Score: 222.190536
- Max Citation Score: 226.61855
- Similarity Product: 142.12610620856285

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test