PATENT CLAIM ANALYSIS

Application Number: 16012372
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-04
Patent Classification: ["514", "183000"]

Abstract:
Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.

Claim (Index 16):
A method of treating pancreatic cancer in a human patient who has previously been treated with gemcitabine, the method comprising intravenously administering to the patient in need thereof an antineoplastic therapy once every two weeks, the antineoplastic therapy consisting of: a single dose of 70 mg/m 2  of irinotecan free base in an irinotecan nanoparticle composition comprising irinotecan nanoparticles having a diameter of 80-140 nm, administered in combination with 200 mg/m 2  of the (1) form of leucovorin and 2,400 mg/m 2  of 5-fluorouracil, to treat the pancreatic cancer in the human patient, wherein the irinotecan nanoparticle composition has one or more characteristics selected from the group consisting of:\n a. an area under the plasma concentration curve extrapolated to time infinity (AUC 0-\u221e ) of about 1091-1705 [h\u00b7\u03bcg/mL]; and b. a maximum plasma concentration of about 29-47 micrograms/mL.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 94.0
- Lexical Diversity: 1.22857
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15241128', '14406776', '14851111', '14844500', '14812950']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.828052717344618
- 35 USC 102 Novelty (BERT): 0.7466283208369786
- Combined Prediction Score: 0.819910277693854
- Mean Citation Score: 628.0000880000001
- Max Citation Score: 844.3667
- Similarity Product: 839.5513000041963

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test