PATENT CLAIM ANALYSIS

Application Number: 15947302
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "210180"]

Abstract:
The invention provides a conjugate of formula I: R-L-Y   I  or a salt thereof, wherein R, L, and Y have any of the values described in the specification, as well as compositions comprising a conjugate of formula I. The conjugates are useful for labeling.

Claim (Index 2):
The conjugate of  claim 1  wherein R comprises a moiety of formula (IIIb): or a salt thereof, wherein W is \u2014O\u2014, \u2014S\u2014, or \u2014CR X1 R X2 \u2014; R X1  is selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, or 3-8 membered cycloalkyl, wherein the (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, and 3-8 membered cycloalkyl are optionally substituted with one or more groups independently selected from hydroxy, halo, \u2014CN, \u2014NO 2 , \u2014SR e , -oxo- and \u2014NR e R f ; R X2  is selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, or 3-8 membered cycloalkyl, wherein the (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, and 3-8 membered cycloalkyl are optionally substituted with one or more groups independently selected from hydroxy, halo, \u2014CN, \u2014NO 2 , \u2014SR e , -oxo- and \u2014NR e R f ; R 2  is hydrogen, hydroxy, halo, \u2014CN, \u2014NO 2 , \u2014SR c , \u2014NR c R d , \u2014(C\u2550O)R c , \u2014(C\u2550O)OR c , \u2014O(C\u2550O)R c , \u2014(C\u2550O)NR c R d , \u2014NR c (C\u2550O)R d , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, 3-8 membered cycloalkyl, 3-8 membered heterocycle and (C 1 -C 8 )alkoxy, wherein the (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, 3-8 membered cycloalkyl, 3-8 membered heterocycle and (C 1 -C 8 )alkoxy are optionally substituted with one or more groups independently selected from the group consisting of hydroxy, halo, \u2014CN, \u2014NO 2 , \u2014SR c , \u2014NR c R d , \u2014(C\u2550O)R c , \u2014(C\u2550O)OR c , \u2014O(C\u2550O)R c , \u2014(C\u2550O)NR c R d , and \u2014NR c (C\u2550O)R d ; R c  is selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and 3-8 membered cycloalkyl, wherein the (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and 3-8 membered cycloalkyl are optionally substituted with one or more groups independently selected from the group consisting of hydroxy, halo, \u2014CN, \u2014NO 2 , \u2014SH, -oxo- and \u2014NH 2 ; R d  is selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and 3-8 membered cycloalkyl, wherein the (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and 3-8 membered cycloalkyl are optionally substituted with one or more groups independently selected from the group consisting of hydroxy, halo, \u2014CN, \u2014NO 2 , \u2014SH, -oxo- and \u2014NH 2 ; or R and R d  together with the nitrogen to which they are attached form a 3 to 8 membered heterocyclic ring that is optionally substituted with one or more groups independently selected from the group consisting of hydroxyl, halo and (C 1 -C 8 )alkyl; and each R e  is independently selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and 3-8 membered cycloalkyl, wherein the (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and 3-8 membered cycloalkyl are optionally substituted with one or more groups independently selected from the group consisting of hydroxy, halo, \u2014CN, \u2014NO 2 , \u2014SH, -oxo- and \u2014NH 2 ; and each R f  is independently selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and 3-8 membered cycloalkyl, wherein the (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl and 3-8 membered cycloalkyl are optionally substituted with one or more groups independently selected from the group consisting of hydroxy, halo, \u2014CN, \u2014NO 2 , \u2014SH, -oxo- and \u2014NH 2 ; or R e  and R f  together with the nitrogen to which they are attached form a 3 to 8 membered heterocyclic ring that is optionally substituted with one or more groups independently selected from the group consisting of hydroxyl, halo and (C 1 -C 8 )alkyl.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 91.0
- Lexical Diversity: 1.41667
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10641427', '14324560', '15040475', '15357536', '15088373']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8043115900900568
- 35 USC 102 Novelty (BERT): 0.5105120746238548
- Combined Prediction Score: 0.7749316385434366
- Mean Citation Score: 256.45601600000003
- Max Citation Score: 269.05646
- Similarity Product: 178.1153926853109

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test