PATENT CLAIM ANALYSIS

Application Number: 15936686
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["424", "134100"]

Abstract:
The present disclosure relates to a method for the treatment of a non-pathogen associated inflammatory disorders in a subject in need thereof, comprising administering to said subject an isolated peptide which specifically binds to an amino acid sequence within the dimer interface of a T cell costimulatory pathway member, particularly the T cell costimulatory pathway members CD28 and CTLA4. The present disclosure also relates to pharmaceutical compositions comprising the isolated peptide and to use of the peptide in treating of a non-pathogen associated inflammatory disorders.

Claim (Index 4):
The isolated peptide or pharmaceutical composition for use according to any one of  claim 1  to  3 , wherein said isolated peptide has an amino acid sequence that corresponds to a region of from 6 to 14 consecutive amino acid residues within human CD28 (SEQ ID NO: 1) or within human CTLA4 (SEQ ID NO: 2), which region harbors one or more amino acid residues of the crystallographic homodimer interface and any functional derivatives of said peptide, wherein said functional derivatives maintain the ability to bind to said crystallographic homodimer interface of CD28 at a binding affinity characterized by a K D  of from about 0.1 to about 30 micromolar and inhibits non-pathogen induced inflammatory response, as determined by a reduction in the level of at least one of the inflammatory cytokines IL2, interferon-\u03b3 (IFN-\u03b3) and tumor necrosis factor-\u03b1 (TNF-\u03b1) and/or by reduction in the level of cyclooxygenase 2 (cox-2) and/or by a decrease in the number of F4/80-positive cells.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 90.0
- Lexical Diversity: 1.7451
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15035571', '15558080', '13392548', '09888324', '14398260']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8033666110926412
- 35 USC 102 Novelty (BERT): 0.6609192600597961
- Combined Prediction Score: 0.7891218759893567
- Mean Citation Score: 509.97055599999993
- Max Citation Score: 840.2424300000001
- Similarity Product: 599.3128639597678

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test