PATENT CLAIM ANALYSIS

Application Number: 16222951
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-07
Patent Classification: ["800", "006000"]

Abstract:
Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human V H  gene segment, a plurality of human D H  gene segments and a plurality of human J H  gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

Claim (Index 56):
The method of  claim 55 , wherein the first modification comprises the replacement of one or more sequences in the mouse immunoglobulin heavy chain locus with the one or more unrearranged human immunoglobulin gene sequences.

Metadata:
- Claim Count in Document: 77.0
- Percentile: 98.0
- Lexical Diversity: 2.06557
- Patent Class: 800.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13788997', '13566765', '14682859', '15585023', '16059884']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6512694144363166
- 35 USC 102 Novelty (BERT): 0.606769165479737
- Combined Prediction Score: 0.6468193895406587
- Mean Citation Score: 516.7685819999998
- Max Citation Score: 595.55
- Similarity Product: 488.3222427278757

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test