PATENT CLAIM ANALYSIS

Application Number: 15749963
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "235500"]

Abstract:
A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula I.

Claim (Index 12):
The compound according to  claim 1 , wherein the compound is selected from the group consisting of:\n 6-Fluoro-3-(4-methanesulfonyl-phenyl)-1H-indole, N-(2-aminoethyl)-4-(6-fluoro-1H-indol-3-yl)benzamide, (4-(6-fluoro-1H-indol-3-yl)phenyl)(piperazin-1-yl)methanone, 6-fluoro-3-(4-(piperazin-1-ylsulfonyl)phenyl)-1H-indole, 4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)morpholine, 4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, 6-fluoro-3-(3-(piperazin-1-ylsulfonyl)phenyl)-1H-indole, N-(2-aminoethyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, N-(2-aminoethyl)-3-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, 3-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, 3-(4-(((cis)-3,5-dimethylpiperazin-1-yl)sulfonyl)phenyl)-6-fluoro-1H-indole, (4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-yl)methanol, (1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-yl)methanol, (1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-yl)methanol, 3-(4-(((3 S, 5 S)-3,5-dimethylpiperazin-1-yl)sulfonyl)phenyl)-6-fluoro-1H-indole, N-(2-(4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)ethyl)acetamide, (R)-(4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-yl)methanol, (S)-(4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-yl)methanol, 6-fluoro-3-(4-((4-(methylsulfonyl)piperazin-1-yl)sulfonyl)phenyl)-1H-indole, 3-(4-(piperazin-1-ylsulfonyl)phenyl)-1H-indole, 4-(6-fluoro-1H-indol-3-yl)-N-(2-(methyl sulfonamido)-ethyl)benzenesulfonamide, 6-fluoro-3-(2-fluoro-4-(piperazin-1-ylsulfonyl)phenyl)-1H-indole, 3-(4-chloro-3-(piperazin-1-ylsulfonyl)phenyl)-6-fluoro-1H-indole, 6-fluoro-3-(4-(piperazin-1-ylsulfonyl)-3-(trifluoromethyl)phenyl)-1H-indole, 6-fluoro-3-(2-methyl-4-(piperazin-1-ylsulfonyl)phenyl)-1H-indole, 3-(4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)propanamide, 3-(4-(6-fluoro-1H-indol-3-yl)-N-methylphenylsulfonamido)-propanamide, 6-fluoro-3-(3-fluoro-4-(piperazin-1-ylsulfonyl)phenyl)-1H-indole, 6-fluoro-3-(3-methoxy-4-(piperazin-1-ylsulfonyl)phenyl)-1H-indole, N-(2-aminoethyl)-3-(6-fluoro-1H-indol-3-yl)-5-methylbenzenesulfonamide, 6-fluoro-3-(3-(methyl sulfonyl)phenyl)-1H-indole, 5-(6-Fluoro-1H-indol-3-yl)-2-(piperazine-1-sulfonyl)-benzonitrile, N-(2-Amino-ethyl)-5-(6-fluoro-1H-indol-3-yl)-2-methylbenzenesulfonamide, 6-fluoro-3-(3-methyl-4-(piperazin-1-yl sulfonyl)phenyl)-1H-indole, 5-(6-fluoro-1H-indol-3-yl)-2-(piperazin-1-ylsulfonyl)phenol, N-(2-aminoethyl)-2-chloro-5-(6-fluoro-1H-indol-3-yl)-benzenesulfonamide, 2-(6-fluoro-1H-indol-3-yl)-5-(piperazin-1-yl sulfonyl)benzonitrile, N-(2-aminoethyl)-3-chloro-5-(6-fluoro-1H-indol-3-yl)-benzenesulfonamide, N-(2-aminoethyl)-5-(6-fluoro-1H-indol-3-yl)-2-hydroxy-benzenesulfonamide, 4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-one, 5-(6-fluoro-1H-indol-3-yl)-2-(piperazin-1-yl sulfonyl)benzamide, 4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-1-methylpiperazin-2-one, N-(2-aminoethyl)-2-fluoro-5-(6-fluoro-1H-indol-3-yl)-benzenesulfonamide, N-(2-aminoethyl)-3-fluoro-5-(6-fluoro-1H-indol-3-yl)-benzenesulfonamide, 3-(3-chloro-4-(piperazin-1-ylsulfonyl)phenyl)-6-fluoro-1H-indole, 4-(6-fluoro-1H-indol-3-yl)-N-(tetrahydro-pyran-4-yl)-benzenesulfonamide, 6-fluoro-N,N-dimethyl-3-(4-(piperazin-1-ylsulfonyl)phenyl)-1H-indole-1-carboxamide, 4-(6-fluoro-1H-indol-3-yl)-N-(2-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-ethyl)benzenesulfonamide, 3-(4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)-N,N-dimethylpropanamide, 3-(4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)-N-methylpropanamide, 1-(6-fluoro-3-(4-(piperazin-1-ylsulfonyl)phenyl)-1H-indol-1-yl)propan-1-one, 1-(6-fluoro-3-(4-(piperazin-1-ylsulfonyl)phenyl)-1H-indol-1-yl)-3-methyl-butan-1-one, 4-(4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)butanamide, 4-(4-(6-fluoro-1H-indol-3-yl)-N-methylphenyl sulfonamido)-butanamide, (R)-4-(6-fluoro-1H-indol-3-yl)-N-(tetrahydrofuran-3-yl)benzenesulfonamide, N-(2-aminoethyl)-5-(6-fluoro-1H-indol-3-yl)-2-methylbenzenesulfonamide, 5-(6-fluoro-1H-indol-3-yl)-N-methyl-2-(piperazin-1-ylsulfonyl)-benzamide, (cis)-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)pyrrolidine-3,4-diol, 4-(6-fluoro-1H-indol-3-yl)-N-(2-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl)-benzenesulfonamide, 6-fluoro-N-methyl-3-(4-(piperazin-1-yl sulfonyl)phenyl)-1H-indole-1-carboxamide, N-(2-aminoethyl)-3-(6-fluoro-1H-indol-3-yl)-5-methoxybenzenesulfon-amide, N-(2-aminoethyl)-4-fluoro-3-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, (1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)azetidin-3-yl)methanol, (S)-4-(6-fluoro-1H-indol-3-yl)-N-(tetrahydrofuran-3-yl)benzenesulfonamide, 1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)azetidin-3-ol, (3 S, 4 S) 1-[4-(6-Fluoro-1H-indol-3-yl)-benzenesulfonyl]-pyrrolidine-3,4-diol, 1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)azetidine-3-carboxamide, N-(azetidin-3-yl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, N-(2-aminoethyl)-3-(6-fluoro-1H-indol-3-yl)-5-hydroxybenzenesulfon-amide, 1-(6-fluoro-3-(4-(piperazin-1-yl sulfonyl)phenyl)-1H-indol-1-yl)ethanone, 3-(3,5-dimethyl-4-(piperazin-1-yl sulfonyl)phenyl)-6-fluoro-1H-indole, N-(2-(1H-1,2,3-triazol-4-yl)ethyl)-4-(6-fluoro-1H-indol-3-yl) benzenesulfonamide, N-(2-(1H-imidazol-2-yl)ethyl)-4-(6-fluoro-1H-indol-3-yl)-benzenesulfonamide, (3R, 4R)-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)pyrrolidine-3,4-diol, 3-(3,5-difluoro-4-(piperazin-1-ylsulfonyl)phenyl)-6-fluoro-1H-indole, 3-(3,5-dichloro-4-(piperazin-1-ylsulfonyl)phenyl)-6-fluoro-1H-indole, (R)-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)pyrrolidin-3-ol, 6-fluoro-3-(4-(piperazin-1-yl sulfonyl)phenyl)-1H-indole-1-carboxamide, (S)-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)pyrrolidin-3-ol, (3 S, 4 S)-4-fluoro-1-{[4-(6-fluoro-1H-indol-3-yl)phenyl]sulfonyl}-pyrrolidin-3-amine, (+)-(cis)-4-fluoro-1-{[4-(6-fluoro-1H-indol-3-yl)phenyl]sulfonyl}-pyrrolidin-3-amine, (3R, 4R)-4-fluoro-1-{[4-(6-fluoro-H-indol-3-yl)phenyl] sulfonyl}-pyrrolidin-3-amine, (\u2212)-(cis)-4-fluoro-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-pyrrolidin-3-amine, 2-[(1-{[4-(6-fluoro-1H-indol-3-yl)phenyl] sulfonyl}piperidin-4-yl)oxy]-acetamide, 4-(6-fluoro-1H-indol-3-yl)-N-[1-(4-methyl-4H-1,2,4-triazol-3-yl)ethyl]-benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-[(4-methyl-5-oxomorpholin-2-yl-methyl]benzenesulfonamide, N-(1,1-dioxidotetrahydrothiophen-3-yl)-4-(6-fluoro-1H-indol-3-yl)-benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-[2-(methylsulfonyl)ethyl]benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-benzenesulfonamide, 1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-1,4-diazepan-5-one, 4-(6-fluoro-1H-indol-3-yl)-N-(1-methyl-1H-pyrazol-5-yl)-benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-benzenesulfonamide, (\u2212)-(R)-4-(6-fluoro-1H-indol-3-yl)-N-(2-hydroxypropyl)benzenesulfonamide, (+)-(S)-4-(6-fluoro-1H-indol-3-yl)-N-(2-hydroxypropyl)benzenesulfonamide, (cis)-3-(4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)cyclobutanecarboxamide, 4-(6-fluoro-1H-indol-3-yl)-N-[(2R)-1-hydroxypropan-2-yl]benzenesulfonamide, (Trans)-3-(4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)cyclobutanecarboxamide, 4-(6-fluoro-1H-indol-3-yl)-N-methyl-N-(2-sulfamoylethyl)-benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-[2-(1H-1,2,4-triazol-1-yl)ethyl]benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-methyl-N-[2-(methyl sulfamoyl)ethyl]benzenesulfonamide, (\u2212)-(6-fluoro-1H-indol-3-yl)-N-[(2 S)-1-hydroxypropan-2-yl]-benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-(3-oxo-3-(piperazin-1-yl)propyl) benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-(3-(4-methylpiperazin-1-yl)-3-oxopropyl) benzenesulfonamide, (\u2212)-(S)-3-(4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)-N-(tetrahydrofuran-3-yl)propanamide, (\u2212)-N-(3-((3 S, 4 S)-3-amino-4-fluoropyrrolidin-1-yl)-3-oxopropyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-(3-morpholino-3-oxopropyl)-benzenesulfonamide, (+)-(R)-3-(4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)-N-(tetrahydrofuran-3-yl)propanamide, N-(2-(4-(6-fluoro-1H-indol-3-yl)phenyl sulfonamido)ethyl)-morpholine-4-carboxamide, N-(2-(4-(6-fluoro-1H-indol-3-yl)phenyl sulfonamido)ethyl)piperazine-1-carboxamide, N-(2-(4-(6-fluoro-1H-indol-3-yl)phenyl sulfonamido)ethyl)-4-methylpiperazine-1-carboxamide, 4-(6-fluoro-1H-indol-3-yl)-N-((2S, 3R)-3-hydroxybutan-2-yl)-N-(2-hydroxyethyl)benzenesulfonamide, (S)-(4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)morpholin-3-yl)methanol, 1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-3-(1-methyl-1H-pyrazol-5-yl)pyrrolidin-3-ol 4-(6-fluoro-1H-indol-3-yl)-N-(2-hydroxyethyl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)benzenesulfonamide, (R)-(4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)morpholin-3-yl)methanol, S)-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-3-methylpyrrolidin-3-ol, 4-(6-fluoro-1H-indol-3-yl)-N-(2-hydroxyethyl)-N-(3-hydroxypropyl)benzenesulfonamide, 4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-1,4-oxazepan-6-ol, 1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-3-(pyrimidin-4-yl)pyrrolidin-3-ol, 1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-3-(pyrimidin-5-yl)pyrrolidin-3-ol, 4-(6-fluoro-1H-indol-3-yl)-N-(2-hydroxy-2-(pyridazin-3-yl)ethyl)-N-methylbenzenesulfonamide, 1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-3-((2-methyl-1H-imidazol-1-yl)methyl)piperidin-3-ol, ((2S, 4S)-4-fluoro-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)pyrrolidin-2-yl)methanol, 1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)pyrrolidin-3-ol, ((2R, 4R)-4-fluoro-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)pyrrolidin-2-yl)methanol, ((2R, 4 S)-4-fluoro-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)pyrrolidin-2-yl)methanol, 1-((1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-3-hydroxypyrrolidin-3-yl)methyl)pyrrolidin-2-one, (3 S, 4R)-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperidine-3,4-diol, (2R, 3R, 4 S, 5 S)-5-fluoro-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-2-(hydroxymethyl)piperidine-3,4-diol, (3R, 4R)-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperidine-3,4-diol, 1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-3-((2-methyl-1H-imidazol-1-yl)methyl)pyrrolidin-3-ol, 1-((1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-3-hydroxypiperidin-3-yl)methyl)pyrrolidin-2-one, 4-(6-fluoro-1H-indol-3-yl)-N-(2-hydroxy-2-(1H-imidazol-2-yl)ethyl)-N-methylbenzenesulfonamide, (2 S, 3 S, 4 S)-1-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-2-(hydroxymethyl)pyrrolidine-3,4-diol, 4-(6-fluoro-1H-indol-3-yl)-N-(2-hydroxy-2-(pyrazin-2-yl)ethyl)-N-methylbenzenesulfonamide, 3-chloro-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, 3,5-dichloro-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, 2-(5-(6-fluoro-1H-indol-3-yl)-2-sulfamoylphenyl)-N,N-dimethylacetamide, 4-(6-fluoro-1H-indol-3-yl)-2-(2-hydroxyethyl)benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-2-(2-(methylamino)ethyl)benzenesulfonamide, 2-(2-(dimethylamino)ethyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-2-(2,2,2-trifluoroethyl)benzenesulfonamide, 2-(5-(6-fluoro-1H-indol-3-yl)-2-sulfamoylphenyl)-N-methylacetamide, 2-(5-(6-fluoro-1H-indol-3-yl)-2-sulfamoylphenyl)acetamide, 4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-1-methylpiperazine-2, 6-dione, (R)-1-(2,3-dihydroxypropyl)-4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-one, (S)-1-(2,3-dihydroxypropyl)-4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-one, 1-(2-aminoethyl)-4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-one, 1-(2-(dimethylamino)ethyl)-4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-one, 4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-1-(2-(methylamino)ethyl)piperazin-2-one, 4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-1-(2-hydroxyethyl)piperazin-2-one, 1-(3-aminopropyl)-4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazin-2-one, 4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)-1-(3-(methylamino)propyl)piperazin-2-one, 1-(3-(dimethylamino)propyl)-4-((4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonyl)piperazine-2-one, 4-(6-fluoro-1H-indol-3-yl)-N-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)benzenesulfonamide, N-((1,2,4-oxadiazol-3-yl)methyl)-4-(6-fluoro-1H-indol-3-yl) benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-(2-hydroxyethyl)benzenesulfonamide, 3-chloro-4-(6-fluoro-1H-indol-3-yl)-N-(2-hydroxyethyl)benzenesulfonamide, (\u2212)-4-(6-fluoro-1H-indol-3-yl)-N-(2-(methylsulfinyl)ethyl)benzenesulfonamide, (+)-4-(6-fluoro-1H-indol-3-yl)-N-(2-(methylsulfinyl)ethyl)benzenesulfonamide, 4-(6-fluoro-1H-indol-3-yl)-N-(2-(2-methyl-1H-imidazol-4-yl)ethyl)benzenesulfonamide, 3-(2-ethyl-4-(6-fluoro-1H-indol-3-yl)phenylsulfonamido)propanamide, 3-((4-(6-fluoro-1H-indol-3-yl)-2-isopropylphenyl)sulfonamido)propanamide, 3-((4-(6-fluoro-1H-indol-3-yl)-2-isobutylphenyl)sulfonamido)propanamide, 3-((4-(6-fluoro-1H-indol-3-yl)-2-(methoxymethyl)phenyl)sulfonamido)propanamide, 3-((4-(6-fluoro-1H-indol-3-yl)-2-isopropoxyphenyl)sulfonamido)propanamide, 3-((4-(6-fluoro-1H-indol-3-yl)-2-(hydroxymethyl)phenyl)sulfonamido)propanamide, 3-((4-(6-fluoro-1H-indol-3-yl)-2-(trifluoromethyl)phenyl)sulfonamido)propanamide, N-(3-((cis)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, (+)-N-(3-((3R, 4R)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, (\u2212)-N-(3-((3 S, 4S)-3,4-dihydroxypyrrolidin-1-yl)-3-oxopropyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, (\u2212)-N-(3-((3 S.4R)-3-amino-4-fluoropyrrolidin-1-yl)-3-oxopropyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, (+)-N-(3-((3 S, 4R)-3-amino-4-fluoropyrrolidin-1-yl)-3-oxopropyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, (+)-N-(3-((3R, 4R)-3-amino-4-fluoropyrrolidin-1-yl)-3-oxopropyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, 3-((2-(2,2-difluoroethyl)-4-(6-fluoro-1H-indol-3-yl)phenyl)sulfonamido)propanamide, 4-(6-fluoro-1H-indol-3-yl)-2-(hydroxymethyl)benzenesulfonamide, 2-(aminomethyl)-4-(6-fluoro-1H-indol-3-yl)benzenesulfonamide, (5-(6-fluoro-1H-indol-3-yl)-2-(methylsulfonyl)phenyl)methanamine, or 2-(5-(6-fluoro-1H-indol-3-yl)-2-(methylsulfonyl)phenyl)ethanol.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 88.0
- Lexical Diversity: 1.88679
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14619589', '15072534', '14076016', '14765556', '15546251']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8302504435544923
- 35 USC 102 Novelty (BERT): 0.5626208309924186
- Combined Prediction Score: 0.8034874822982849
- Mean Citation Score: 378.49669200000005
- Max Citation Score: 465.86142
- Similarity Product: 355.6423651268507

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test