PATENT CLAIM ANALYSIS

Application Number: 15772699
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-08
Patent Classification: ["514", "254000"]

Abstract:
Provided are ARTS mimetic compounds that act as novel antagonists for XIAP and Bcl-2. Further, the novel ARTS mimetic compounds of the presently claimed subject matter induce apoptosis and/or differentiation in premalignant and malignant cells and thereby restore their normal-like phenotype. Further provided are compositions, methods and uses of said ARTS mimetic compounds in the treatment of cancer and premalignant conditions.

Claim (Index 64):
A method for treating, preventing, inhibiting, reducing, eliminating, protecting or delaying the onset of a proliferative disorder in a subject in need thereof, said method comprises administering to said subject a therapeutically effective amount of at least one ARTS mimetic compound any vehicle, matrix, nano- or micro-particle or any composition comprising the same, said ARTS mimetic compound having the general formula (I) or a pharmaceutically acceptable salt or hydrate thereof including any stereoisomer thereof wherein:\n R 1  is independently selected from H, C 1 -C 12  alkyl, C 2 -C 12  alkenyl, C 2 -C 12 alkynyl; \n R 2  is independently selected from \u2014C(\u2550O)\u2014X\u2014R 3 , \u2014S(\u2550O)\u2014X\u2014R 3\u2032 ; \n X is a heteroatom independently selected from N-containing group, O and S; \n R 3  and R 3\u2032 , independently of each other may be selected independently from H, C 1 -C 12  alkyl, C 2 -C 12  alkenyl, C 2 -C 12 alkynyl; \n R 5  is -L1-R 7 -L2-R 8 ; \n L1 and L2, independently of each other, are selected independently from \u2014(CH 2 ) n \u2014; \u2014NH\u2014C(\u2550O)\u2014(CH 2 ) n \u2014, \u2014C(\u2550O)\u2014NH\u2014(CH 2 ) n \u2014; \u2014S\u2014S\u2014(CH 2 ) n \u2014; \u2014O\u2014(CH 2 ) n \u2014; \u2014NH\u2014(CH 2 ) n \u2014; C(\u2550O)\u2014(CH 2 ) n \u2014; \u2014S\u2014(CH 2 ) n \u2014; \u2014NH\u2014S(\u2550O) n \u2014(CH 2 ) n \u2014; \n n is independently 0 to 5; \n R 7  is independently selected from straight or branched C 1 -C 12  alkylene, straight or branched C 2 -C 12  alkenylene, straight or branched C 2 -C 12  alkynylene, a ring system containing five to twelve atoms, each optionally substituted; \n R 8  is independently selected from H, straight or branched C 1 -C 12  alkyl, straight or branched C 2 -C 12  alkenyl, straight or branched C 2 -C 12  alkynyl, a ring system containing five to twelve atoms, each optionally substituted; \n R 6  is independently selected from H, halogen, CN, NO 2 , C 1 -C 12  alkoxy, straight or branched C 1 -C 12  alkyl, straight or branched C 2 -C 12  alkenyl, straight or branched C 2 -C 12  alkynyl.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 93.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11632079', '12270374', '11800220', '10586271', '14386747']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7588134109100707
- 35 USC 102 Novelty (BERT): 0.5294997141602135
- Combined Prediction Score: 0.7358820412350849
- Mean Citation Score: 296.802926
- Max Citation Score: 340.8475
- Similarity Product: 190.527642556578

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test