PATENT CLAIM ANALYSIS

Application Number: 16173120
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "252020"]

Abstract:
The present disclosure provides pyrrolopyrimidine compounds and methods of use therefor. For example, the disclosure provides certain pyrrolopyrimidine compounds capable of inhibiting JAK kinases. The disclosure further provides the pharmaceutical comp6sitions containing these pyrrolopyrimidine compounds, and use of these pyrrolopyrimidine compounds in the treatment of disorders or diseases, such as inflammatory diseases and cancer.

Claim (Index 32):
A method of treating in a subject a cancer responsive to inhibition of at least one kinase chosen from JAK1, JAK2, JAK3 and TYK2 comprising administering to said subject in need thereof an effective amount of a compound of formula (1): wherein R 1  is chosen from hydrogen, alkyl, cycloalkyl and heterocycle, each of the said alkyl, cycloalkyl, and heterocycle, in R 1  is optionally substituted with one or more groups chosen from optionally substituted lower alkyl, optionally substituted aryl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, \u2014C(O)R a , \u2014C(O)OR b , \u2014CN, \u2014C(O)NR c R d , halo, optionally substituted haloalkyl, optionally substituted heterocycle, optionally substituted heteroaryl, \u2014NR c R d , \u2014NR e C(O)R a , \u2014NR e C(O)OR b , \u2014NR e C(O)NR c R d , \u2014NR e S(O) n R f , \u2014NR e S(O) n NR c R d , \u2014NO 2 , \u2014OR b , \u2014S(O) n R f , and \u2014S(O) n NR c R d ; R 2  is which is optionally substituted with one or more groups chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, (C(O)R a , \u2014C(O)OR b , \u2014CN, \u2014C(O)NR c R d , halo, optionally substituted haloalkyl, optionally substituted heterocycle, optionally substituted heteroaryl, \u2014NR c R d , \u2014NR e C(O)R a , \u2014NR e C(O)OR b , \u2014NR e C(O)NR c R d , \u2014NR e S(O) n R f , \u2014NR e S(O) n NR c R d , \u2014NO 2 , \u2014OR b , \u2014S(O) n R f , and \u2014S(O) n NR c R d ;\n m is 1; \n n is chosen from 0, 1, and 2; \n for each occurrence, R a , R b , R c , R d , R e  and R f  are each independently chosen from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted haloalkyl, optionally substituted heteroaryl and optionally substituted heterocycle, \n or R c  and R d , with the nitrogen to which they are attached, combine to form a heterocycle ring, which is optionally substituted with one or more groups chosen from halo, lower alkyl, hydroxy, and lower alkoxy, wherein the heterocycle ring further optionally comprises one or two additional heteroatoms chosen from N, O and S, \n wherein each optionally substituted group above can be unsubstituted or independently substituted with at least one substituent independently chosen from C 1 -C 4  alkyl, cycloalkyl, aryl, heterocycle, heteroaryl, aryl-C 1 -C 4  alkyl, heteroaryl-C 1 -C 4  alkyl-, C 1 -C 4  haloalkyl-, alkyl, \u2014OC 1 -C 4  alkylphenyl, \u2014C 1 -C 4  alkylOH, \u2014C 1 -C 4  alkyl-O\u2014C 1 -C 4  alkyl, \u2014OC 1 -C 4  haloalkyl, halo, \u2014OH, \u2014NH 2 , \u2014C 1 -C 4  alkyl-NH 2 , \u2014N(C 1 -C 4  alkyl)(C 1 -C 4  alkyl), \u2014NH(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl)(C 1 -C 4  alkylphenyl), \u2014NH(C 1 -C 4  alkylphenyl), cyano, nitro, oxo, \u2014CO 2 H, \u2014C(O)OC 1 -C 4  alkyl, \u2014CON(C 1 -C 4  alkyl)(C 1 -C 4  alkyl), \u2014CONH(C 1 -C 4  alkyl), \u2014CONH 2 , \u2014NHC(O)(C 1 -C 4  alkyl), \u2014NHC(O)(phenyl), \u2014N(C 1 -C 4  alkyl)C(O)(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl)C(O)(phenyl), \u2014C(O)C 1 -C 4  alkyl, \u2014C(O)C 1 -C 4  haloalkyl, \u2014OC(O)(C 1 -C 4  alkyl), \u2014SO 2 (C 1 -C 4  alkyl), \u2014SO 2 (phenyl), \u2014SO 2 (C 1 -C 4  haloalkyl), \u2014SO 2 NH 2 , \u2014SO 2 NH(C 1 -C 4  alkyl), \u2014SO 2 NH(phenyl), \u2014NHSO 2 (C 1 -C 4  alkyl), \u2014NHSO 2 (phenyl), and \u2014NHSO 2 (C 1 -C 4  haloalkyl), in which each of phenyl, aryl, heterocycle, and heteroaryl is optionally substituted by one or more groups chosen from halo, cycloalkyl, heterocycle, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl-, \u2014OC 1 -C 4  alkyl, C 1 -C 4  alkyl-OH, \u2014C 1 -C 4  alkyl-O\u2014C 1 -C 4  alkyl, \u2014OC 1 -C 4  haloalkyl, cyano, nitro, \u2014NH 2 , \u2014CO 2 H, \u2014C(O)OC 1 -C 4  alkyl, -CON(C 1 -C 4  alkyl)(C 1 -C 4  alkyl), \u2014CONH(C 1 -C 4  alkyl), \u2014CONH 2 , \u2014NHC(O)(C 1 -C 4  alkyl), \u2014N(C 1 -C 4  alkyl)C(O)(C 1 -C 4  alkyl), \u2014SO 2 (C 1 -C 4  alkyl), \u2014SO 2 (phenyl), \u2014SO 2 (C 1 -C 4  haloalkyl), \u2014SO 2 NH 2 , SO 2 NH(C 1 -C 4  alkyl), \u2014SO 2 NH(phenyl), \u2014NHSO 2 (C 1 -C 4  alkyl), \u2014NHSO 2 (phenyl), and \u2014NHSO 2 (C 1 -C 4  haloalkyl); or \n a compound chosen from compounds 41,42, 44, 58, 61, 66-78, 81-83, 87, 89-92, 96-102, 121, 123, 124, 126, 128, 137, 144-147, 149, 150, 155-160, 162, 168-178, 181, 183, 186, 488, 190-200, and 209-260, \n and/or at least one pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 97.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13817802', '15134223', '14691606', '14023158', '12784916']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7672417676237335
- 35 USC 102 Novelty (BERT): 0.5756509550693563
- Combined Prediction Score: 0.7480826863682959
- Mean Citation Score: 419.39061
- Max Citation Score: 502.4852
- Similarity Product: 389.0636774533272

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test