PATENT CLAIM ANALYSIS

Application Number: 16128360
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["800", "003000"]

Abstract:
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that present a choice of two human light chain variable gene segments such that the immunoglobulin light chains expresses by the mouse comprise one of the two human light chain variable gene segments. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided.

Claim (Index 43):
The method of  claim 38 , wherein the germline genome of the genetically modified mouse comprises in order: the human V\u03ba1-39 gene segment, the human V\u03ba3-20 gene segment, the human J\u03ba1 gene segment, the human J\u03ba2 gene segment, the human J\u03ba3 gene segment, the human J\u03ba4 gene segment, and the human J\u03ba5 gene segment.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 97.0
- Lexical Diversity: 1.86885
- Patent Class: 800.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15700973', '14473970', '13798455', '14705916', '13566765']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.802581547422192
- 35 USC 102 Novelty (BERT): 0.7342032083460224
- Combined Prediction Score: 0.7957437135145751
- Mean Citation Score: 885.906042
- Max Citation Score: 940.1538
- Similarity Product: 818.3839599878668

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test