PATENT CLAIM ANALYSIS

Application Number: 16057766
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-11
Patent Classification: ["424", "141100"]

Abstract:
The present invention provides antibodies that bind to human GFRα3 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GFRα3. The antibodies of the invention are useful for the treatment of diseases and disorders associated with one or more GFRα3 biological activities, including the treatment of acute or chronic pain conditions, or inflammatory conditions.

Claim (Index 1):
An isolated monoclonal antibody or an antigen-binding fragment thereof that specifically binds to GFR\u03b13, having one or more of the following characteristics:\n (i) exhibits a K D  ranging from about 10 \u22128  M to about 10 \u221213  M as measured by surface plasmon resonance; (ii) demonstrates the ability to block about 50-100% of the binding of GFR\u03b13 to its ligand, artemin, with an IC 50  value ranging from about 40 pM to about 15 nM; (iii) demonstrates the ability to block about 20% to about 100% of the binding of GFR\u03b13 to a solid support coated with a mixture of artemin and RET; (iv) blocks or inhibits artemin-dependent activation of RET with an IC 50  ranging from about 200 pM to about 50 nM; (v) inhibits or reduces one or more nociceptive responses in an in vivo model of bone cancer pain; (vi) inhibits or reduces artemin-sensitized thermal hyperalgesia in vivo; (vii) inhibits or reduces allodynia in an in vivo model of osteoarthritis; (viii) does not cross-react with other GFR co-receptors for RET; (ix) comprises a heavy chain variable region (HCVR) having an amino acid sequence selected from the group consisting of SEQ ID NO: 2, 18, 34, 50, 66, 82, 98, 114, 130, 146, 162, 178, 194, 210, 226, 242, 258, 274, 290, 306, 322, 338, 354, 381 and 397; or (x) comprises a light chain variable region (LCVR) having an amino acid sequence selected from the group consisting of SEQ ID NOs: 10, 26, 42, 58, 74, 90, 106, 122, 138, 154, 170, 186, 202, 218, 234, 250, 266, 282, 298, 314, 330, 346, 362, 389 and 405.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 96.0
- Lexical Diversity: 1.78049
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15382256', '14577362', '13971965', '14717760', '15621689']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8625183903821954
- 35 USC 102 Novelty (BERT): 0.6393334664810206
- Combined Prediction Score: 0.8401998979920778
- Mean Citation Score: 618.217626
- Max Citation Score: 790.70087
- Similarity Product: 551.2140117585076

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test