PATENT CLAIM ANALYSIS

Application Number: 16152226
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-01
Patent Classification: ["514", "001100"]

Abstract:
The present invention discloses a design for a molecular delivery vehicle capable of delivering a molecular payload to a target cell and its intracellular compartments. Also disclosed are highly pH-sensitive nanoconstruct that takes advantage of the requirement of cationic charge for internalization of CPPs to mask the non-specific internalization, compositions containing nanoconstruct, and methods for forming the same.

Claim (Index 15):
A method of forming a peptide nanoconstruct for targeted cell delivery, comprising:\n attaching a pH-sensitive masking element to a cell targeting element directly or via a peptide linker, wherein: said pH-sensitive masking element is a peptide comprising a histidine-glutamic acid repeat sequence (HE) n  with n=10 to 40 and the glutamic acid E individually replaceable with aspartic acid D, said cell targeting element is a CPP having a cationic charge.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 97.0
- Lexical Diversity: 1.37778
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14648537', '15838164', '14112512', '13318032', '15032668']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7262890509256212
- 35 USC 102 Novelty (BERT): 0.4989096200453679
- Combined Prediction Score: 0.7035511078375959
- Mean Citation Score: 244.26623200000003
- Max Citation Score: 249.67383
- Similarity Product: 185.8250457507473

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test