PATENT CLAIM ANALYSIS

Application Number: 16138418
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["424", "133100"]

Abstract:
Agents that specifically bind TIGIT are disclosed. The TIGIT-binding agents may include polypeptides, antibodies, and/or bispecific agents. Also disclosed are methods of using the agents for enhancing the immune response and/or treatment of diseases such as cancer.

Claim (Index 248):
A method of inhibiting growth of a tumor in a subject, comprising administering to the subject a therapeutically effective amount of an antibody that specifically binds the extracellular domain of TIGIT, wherein the antibody comprises:\n (a) a heavy chain CDR1 comprising GSSLSSSYMS (SEQ ID NO:7), a heavy chain CDR2 comprising IIGSNGNTYYANWAKG (SEQ ID NO:8), a heavy chain CDR3 comprising GGYRTSGMDP (SEQ ID NO:9), a light chain CDR1 comprising QASQSISSYLNW (SEQ ID NO:10), a light chain CDR2 comprising DALKLAS (SEQ ID NO:11), and a light chain CDR3 comprising QQEHSVGNVDN (SEQ ID NO:12); (b) a heavy chain CDR1 comprising GFSLSSSYMS (SEQ ID NO:13), a heavy chain CDR2 comprising IIGSNGNTYYANWAKG (SEQ ID NO:8), a heavy chain CDR3 comprising GGYRTSGMDP (SEQ ID NO:9), a light chain CDR1 comprising QASQNIYSDLAW (SEQ ID NO:81), a light chain CDR2 comprising RASTLAS (SEQ ID NO: 15), and a light chain CDR3 comprising QQEHLVAWIYN (SEQ ID NO: 16); or (c) a heavy chain CDR1 comprising TSDYAWN (SEQ ID NO:57), a heavy chain CDR2 comprising YISYSGSTSYNPSLRS (SEQ ID NO:58), a heavy chain CDR3 comprising ARRQVGLGFAY (SEQ ID NO:59), a light chain CDR1 comprising KASQDVSTAVA (SEQ ID NO:60), a light chain CDR2 comprising SASYRYT (SEQ ID NO:61), and a light chain CDR3 comprising QQHYSTP (SEQ ID NO:62).

Metadata:
- Claim Count in Document: 83.0
- Percentile: 97.0
- Lexical Diversity: 1.3125
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15167166', '15817691', '15449665', '14318247', '14795811']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7624629875917753
- 35 USC 102 Novelty (BERT): 0.6326706604276661
- Combined Prediction Score: 0.7494837548753643
- Mean Citation Score: 489.23687000000007
- Max Citation Score: 645.2174
- Similarity Product: 538.8486988707066

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test