PATENT CLAIM ANALYSIS

Application Number: 15933804
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-02
Patent Classification: ["540", "593000"]

Abstract:
The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

Claim (Index 14):
A method of reducing the number of synthetic steps when producing a compound of formula (7) comprising any one of (a) to (c), (a) producing a compound of the formula (7a) from a compound of the formula (7c) and (2R)-2-fluoropropanol (7b), and producing the compound of the formula (7) from the compound of the formula (7a): where in the formula, Lv represents leaving group, Me represents methyl, iPr represents isopropyl, and K represents isopropyl or (2R)-2-fluoropropyl; (b) producing the compound of the formula (7) from the compound of the formula (7e) and (2R)-2-fluoropropanol (7b): where in the formula, Lv represents a leaving group and Me represents methyl; or (c) producing a compound of the formula (7g) from a compound of the formula (7i) and (S)-glycidyl 3-nitrobenzenesulfonate (7h), producing a compound of the formula (7f) by hydrogenation reaction of the compound of the formula (7g), and producing the compound of the formula (7) from the compound of the formula (7f):

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.64706
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14406568', '15434678', '10554150', '11598732', '10584933']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6294430170995995
- 35 USC 102 Novelty (BERT): 0.5231635010334204
- Combined Prediction Score: 0.6188150654929816
- Mean Citation Score: 236.9313
- Max Citation Score: 306.3594
- Similarity Product: 240.88910080955029

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test