PATENT CLAIM ANALYSIS

Application Number: 16095822
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-06
Patent Classification: ["514", "210210"]

Abstract:
The present invention relates to a substituted purine derivative of formula (1) wherein R 1  is alkoxy or the like, R 2  is alkyl or the like, Ring Q 1  is aryl or the like, W 1  is alkylene or the like, Ring Q 2  is aromatic carbocyclyl or the like, n is 1-4, R 3  is hydrogen atom or the like, X 1  is single bond or the like, W 2  is alkylene or the like, and R 4  is hydrogen atom or the like, or a pharmaceutically acceptable salt thereof, which has a potent inhibitory effect against TLR7, and thereby is useful for treating autoimmune disease.

Claim (Index 1):
A compound of formula (1): or a pharmaceutically acceptable salt thereof\n wherein \n R 1  is optionally-substituted C 1-6  alkoxy, optionally-substituted C 3-7  cycloalkoxy, optionally-substituted 4- to 10-membered saturated heterocyclyloxy, optionally-substituted C 1-6  alkyl, optionally-substituted C 3-7  cycloalkyl, optionally-substituted C 1-6  alkylthio, optionally-substituted 4- to 10-membered saturated heterocyclyl, optionally-substituted amino, halogen atom, or hydroxy; \n R 2  is optionally-substituted C 1-6  alkyl, optionally-substituted C 3-7  cycloalkyl, or optionally-substituted amino; \n Ring Q 1  is optionally-substituted C 6-10  aryl, or optionally-substituted 5- to 10-membered heteroaryl; \n W 1  is single bond, or optionally-substituted C 1-4  alkylene; \n Ring Q 2  is C 6-10  aromatic carbocyclyl, or 5- to 10-membered aromatic heterocyclyl; \n n is 1, 2, 3, or 4; \n R 3  is, independently if there are plural R 3 , hydrogen atom, halogen atom, cyano, hydroxy, optionally-substituted C 1-6  alkyl, optionally-substituted C 1-6  alkoxy, optionally-substituted C 3-7  cycloalkyl, optionally-substituted C 3-7  cycloalkoxy, or optionally-substituted amino; \n Q 2 -X 1 \u2014 is Q 2 -(single bond)-, Q 2 -(CH 2 ) m \u2014O\u2014, Q 2 -(CH 2 ) m \u2014S\u2014, Q 2 -(CH 2 ) m \u2014S(O) 2 \u2014, Q 2 -(CH 2 ) m \u2014NR a S(O) 2 \u2014, Q 2 -(CH 2 ) m \u2014S(O) 2 NR a \u2014, Q 2 -(CH 2 ) m \u2014C(O)\u2014, Q 2 -(CH 2 ) m \u2014NR a \u2014, Q 2 -(CH 2 ) m \u2014NR a C(O)\u2014, or Q 2 -(CH 2 ) m \u2014C(O)NR a \u2014, wherein R a  is hydrogen atom or C 1-6  alkyl; m is 0, 1, or 2; \n W 2  is single bond, or optionally-substituted C 1-8  alkylene; and \n R 4  is hydrogen atom, \u2014OR b  (wherein R b  is hydrogen atom, optionally-substituted C 1-6  alkyl, optionally-substituted C 1-6  alkylcarbonyl, optionally-substituted aminocarbonyl, or optionally-substituted C 1-6  alkylsulfonyl), \u2014NR c R d  (wherein R c  is hydrogen atom or optionally-substituted C 1-6  alkyl; and R d  is hydrogen atom, optionally-substituted C 1-6  alkyl, optionally-substituted C 1-6  alkylcarbonyl, optionally-substituted C 1-6  alkoxycarbonyl, or optionally-substituted C 1-6  alkylsulfonyl), optionally-substituted 4- to 10-membered saturated heterocyclyl, or optionally-substituted 5- to 10-membered heteroaryl.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 97.0
- Lexical Diversity: 2.08475
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13508905', '13819881', '13395429', '13380376', '11547036']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7895847843982318
- 35 USC 102 Novelty (BERT): 0.5440652851221446
- Combined Prediction Score: 0.7650328344706231
- Mean Citation Score: 368.977162
- Max Citation Score: 377.30194
- Similarity Product: 332.82757133457903

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test