PATENT CLAIM ANALYSIS

Application Number: 15970605
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "093200"]

Abstract:
The present invention relates to compositions and methods of generating modified hematopoietic stem or progenitor cells. One aspect of the invention includes a modified hematopoietic stem or progenitor cell comprising a nucleic acid capable of decreasing expression of an endogenous gene or a portion thereof, wherein the endogenous gene encodes a polypeptide comprising an antigen domain targeted by a chimeric antigen receptor (CAR). Another aspect of the invention includes a method for generating a modified hematopoietic stem or progenitor cell. Also included are methods and pharmaceutical compositions comprising the modified cell for adoptive therapy and treating a condition, such as an autoimmune disease or cancer.

Claim (Index 51):
A method for generating a population of modified hematopoietic stem and progenitor cells (HSPCs), comprising introducing into the HSPCs a CRISPR system comprising:\n a guide nucleic acid, wherein the guide nucleic acid comprises the nucleotide sequence set forth in SEQ ID NO:3; and a single-stranded oligonucleotide donor (ssODN) sequence, wherein the ssODN sequence comprises the nucleotide sequence set forth in SEQ ID NO:5, wherein the CRISPR system produces an insertion and/or deletion capable of downregulating gene expression of CD33.

Metadata:
- Claim Count in Document: 68.0
- Percentile: 93.0
- Lexical Diversity: 1.79365
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15655432', '14420318', '13817726', '10261078', '14469308']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6894503085512714
- 35 USC 102 Novelty (BERT): 0.5375042484278636
- Combined Prediction Score: 0.6742557025389306
- Mean Citation Score: 337.81790600000005
- Max Citation Score: 363.6766
- Similarity Product: 250.6845566883088

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test