PATENT CLAIM ANALYSIS

Application Number: 15942321
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "210020"]

Abstract:
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Claim (Index 36):
The compound of  claim 25 , wherein D is a 5-membered heteroaryl having the formula or a 6-membered heteroaryl having the formula wherein:\n Q is NR 20 , CR 20 , O or S; \n each T is independently N or CR 21 ; \n each Z is independently N or C, provided that only one Z is N; \n each R 20  and R 21  is independently hydrogen, alkyl, haloalkyl, alkoxy, halogen, hydroxy, or cyano; and \n R 22  and R 23  are taken together with the atoms to which they are attached to form a bicyclic; wherein the bicyclic may contain one more heteroatoms selected from N, S and O; and wherein the bicyclic is optionally substituted with one, two, three, four or five R 30 ; \n wherein each R 30  is independently C 1-6  alkyl, C 2-6  alkenyl, C 3-7  cycloalkyl, C 3-7  heterocyclyl, halogen, cyano, oxo, \u2014NR 31 R 32 , \u2014SO 2 NR 31 R 32 , \u2014C(O)NR 31 R 32 , \u2014C(O)OR 33 , \u2014OR 33 , \u2014NR 33 C(O)R 34 , \u2014NR 33 SO 2 R 35  or \u2014SO 2 R 35 ; wherein the C 1-6  alkyl, C 2-6  alkenyl, C 3-7  cycloalkyl and C 3-7  heterocyclyl of R 30  are optionally substituted with one to four R 40 ; or two R 30  groups are taken together with the parent moiety to with they are attached to form a ring which is optionally substituted with one to four R 40 ; \n each R 31  and R 32  is independently hydrogen or C 1-6  alkyl; or R 31  and R 32  are taken together with the nitrogen atom to which they are attached to form a C 3-7  heterocyclyl optionally substituted with one to four R 40 ; \n each R 33  and R 34  are independently hydrogen or C 1-6  alkyl; \n R 35  is C 1-6  alkyl; \n each R 40  is independently selected from the group consisting of halogen, cyano, oxo, \u2014NR 41 R 42 , \u2014SO 2 NR 41 R 42 , \u2014C(O)NR 41 R 42 , \u2014C(O)OR 43 , \u2014OR 43 , \u2014NR 43 C(O)R 44 , \u2014NR 43 SO 2 R 45  or \u2014SO 2 R 45 ; C 1-6  alkyl, C 1-6  haloalkyl, C 2-9  heteroaryl, C 6-10  aryl, oxo; or two R 4  groups are taken together with the parent moiety to with they are attached to form a ring which is optionally substituted with one to three substituents selected from C 1-6  alkyl, C 1-6  haloalkyl, hydroxyl and oxo; \n each R 41  and R 42  is independently hydrogen or C 1-6  alkyl; or R 41  and R 42  are taken together with the nitrogen atom to which they are attached to form a C 3-7  heterocyclyl optionally substituted with one to three substituents selected from C 1-6  alkyl, C 1-6  haloalkyl, hydroxyl and oxo; \n each R 43  and R 44  are independently hydrogen or C 1-6  alkyl; and \n R 45  is C 1-6  alkyl.

Metadata:
- Claim Count in Document: 140.0
- Percentile: 90.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12530648', '13102720', '15281923', '13266976', '15852639']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.784873882544401
- 35 USC 102 Novelty (BERT): 0.5129125456011704
- Combined Prediction Score: 0.757677748850078
- Mean Citation Score: 269.39763800000003
- Max Citation Score: 276.27457000000004
- Similarity Product: 201.1034948824192

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test