PATENT CLAIM ANALYSIS

Application Number: 15945630
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-10
Patent Classification: ["424", "400000"]

Abstract:
Methods for targeted delivery of therapeutic agents to a target cell or tissue with lipid nanoparticles comprising ApoE3. In embodiments, the invention specifically relates to targeted delivery of anticancer drugs, antibiotics, antifungal drugs, and diagnostic contrast agents, and associated treatment and diagnostic methods. In embodiments, diseases/conditions treated include those associated with over-expression of LDL receptors.

Claim (Index 11):
A method of treating a disease associated with brain tissue, comprising:\n administering a therapeutically effective amount of a therapeutic agent to an individual having the disease, the therapeutic agent being loaded onto lipid nanoparticles comprising:\n a lipid core comprised of a triglyceride component and a cholesterol ester component; \n a phospholipid layer; \n a surfactant coating surrounding the phospholipid and the lipid core; and \n a human recombinant apolipoprotein (ApoE3) adsorbed to a surface of the nanoparticle without Polysorbate 80, wherein the apolipoprotein is human recombinant ApoE3,\n wherein the therapeutic agent is transported in the lipid nanoparticle across the blood-brain barrier to the target brain tissue through transcytosis independent of LDL receptor binding.

Metadata:
- Claim Count in Document: 48.0
- Percentile: 91.0
- Lexical Diversity: 1.48837
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11648808', '10724833', '11802727', '11802197', '11802198']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7657689928894669
- 35 USC 102 Novelty (BERT): 0.5323151547346009
- Combined Prediction Score: 0.7424236090739803
- Mean Citation Score: 356.06647200000015
- Max Citation Score: 371.93008
- Similarity Product: 251.12975620075227

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test