PATENT CLAIM ANALYSIS

Application Number: 16206000
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["546", "143000"]

Abstract:
A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided. In formula (I), Ar is indazole, 5-isoquinoline, 6-isoquinoline, or their N-oxide. X is —C(═Z)—, wherein Z is N—CN, NH, NR 4 , NCOR 4 , NCONR 4 R 5 , NCO-aryl, S, or O. Y and J are independently H, alkyl, aryl, aminoalkyl, —NH 2 , —CN, —OH, —O-alkyl, —O-aryl, —COOH, —COOR 4 , —CONHR 4 , —CONHCH 2 -aryl, —CONR 4 CH 2 -aryl, —NHCOR 4 , halogen, halogened alkyl, -alkyl-OR 4 , -alkyl-ONO 2 , alkyl-ONO 2 , —OCOOR 4 , —O(C═O)-aryl, —CHR 4 OH, —CH 2 OH, —CH 2 O(C═O)-aryl, —CH 2 O(C═O)—R 4 , —CHR 4 O(C═O)-aryl, —CHR 4 O(C═O)—R 4 , unsaturated carboxylic ester, substituted alkynyl, —NHSO 2 R 4 , —SO 2 R 4 , —SO 2 NHR 4 , or —SO 2 NR 4 R 5 , or Y and J bond together to form a carbocylic or aromatic ring, wherein R 4  and R 5  are independently H, substituted C1-C6 alkyl, substituted aryl, cycloalkyl, alkylaryl, -alkyl-NR 6 R 7 , —S(O) 0-2 -(alkyl-NR 6 R 7 ). R 1 , R 2  and R 3  are H, C1-C6 alkyl, cycloalkyl, aryl, alkylaryl, alkylheteroaryl, alkylheterocycle, wherein any one thereof is optionally substituted with one or more of OH, NO 2 , or NR 8 R 9 .

Claim (Index 1):
A compound of formula (I), or a pharmaceutically acceptable salt thereof: wherein Ar is indazole, 5-isoquinoline, 6-isoquinoline, or their N-oxide, X is \u2014C(\u2550Z)\u2014, wherein Z is N\u2014CN, NH, NR 4 , NCOR 4 , NCONR 4 R 5 , NCO-aryl, S, or O, Y and J are independently H, C 1 -C 6  alkyl, C 6 -C 8  aryl, C 1 -C 6  aminoalkyl, \u2014NH 2 , \u2014CN, \u2014OH, \u2014O-alkyl, \u2014O-aryl, \u2014COOH, \u2014COOR 4 , \u2014CONHR 4 , \u2014CONHCH 2 -aryl, \u2014CONR 4 CH 2 -aryl, \u2014NHCOR 4 , halogen, C 1 -C 6  halogened alkyl, -alkyl-OR 4 , \u2014O-alkyl-OR 4 , -alkyl-ONO 2 , \u2014O-alkyl-ONO 2 , \u2014OCOOR 4 , \u2014O(C\u2550O)-aryl, \u2014CHR 4 OH, \u2014CH 2 OH, \u2014CH 2 O(C\u2550O)-aryl, \u2014CH 2 O(C\u2550O)\u2014R 4 , \u2014CHR 4 O(C\u2550O)-aryl, \u2014CHR 4 O(C\u2550O)\u2014R 4 , unsaturated carboxylic ester, C 2 -C 12  alkynyl, substituted C 2 -C 12  alkynyl, \u2014NHSO 2 R 4 , \u2014SR 4 , \u2014SO 2 R 4 , \u2014SO 2 NHR 4 , or \u2014SO 2 NR 4 R 5 , or Y and J bond together to form a carbocylic or aromatic ring, wherein R 4  and R 5  are independently H, C 1 -C 6  alkyl, C 6 -C 8  aryl, substituted C 1 -C 6  alkyl, substituted C 6 -C 8  aryl, C 5 -C 12  cycloalkyl, C 7 -C 12  alkylaryl, -alkyl-NR 6 R 7 , -alkyl-OR 6 , -alkyl-ONO 2 , \u2014S(O) 0-2 -(alkyl-NR 6 R 7 ), wherein R 6  and R 7  are independently H, alkyl, aryl or bond together with nitrogen atom to form a heterocyclic ring, and R 1 , R 2  and R 3  are H, C 1 -C 6  alkyl, cycloalkyl, aryl, alkylaryl, alkylheteroaryl, alkylheterocycle, wherein any one thereof is optionally substituted with one or more of OH, ONO 2 , or NR 8 R 9 , wherein R 8  and R 9  are independently H, C 1 -C 6  alkyl, C 6 -C 8  aryl or bond together with nitrogen atom to form a heterocyclic ring.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 98.0
- Lexical Diversity: 2.68421
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11575647', '11375259', '11192009', '15356311', '10244088']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8140995511666165
- 35 USC 102 Novelty (BERT): 0.5161606951766293
- Combined Prediction Score: 0.7843056655676178
- Mean Citation Score: 315.593212
- Max Citation Score: 323.54504
- Similarity Product: 251.99793959543223

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test