PATENT CLAIM ANALYSIS

Application Number: 16240677
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["536", "026700"]

Abstract:
In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3  and n are each as defined in Claim  1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

Claim (Index 1):
A method for producing a compound represented by the following formula (II): wherein\n Base independently represents \n wherein each asterisk denotes the site binding to another moiety of the compound represented by the formula (II) above to form said compound; Y 1  independently represents a hydroxyl group protected with a silyl-type protective group, a hydrogen atom, a halogen atom, or a C 1-6  alkoxy group; Q independently represents an oxygen atom; and r and r\u2032 each independently represent an integer of 0 to 100, or a salt thereof, the method comprising the following steps (a0) and (b0): step (a0):\n a compound represented by the following formula (I): \n wherein\n Base is as defined above; \n X represents a benzyl-type protective group; \n R 1  represents an aliphatic acyl-type protective group, \n Y represents a hydroxyl group protected with a silyl-type protective group, a hydrogen atom, a halogen atom or a C 1-6  alkoxy group; \n Z represents an oxygen atom; \n ring Ar represents a benzene ring; \n R 2  represents an optionally substituted C 10-30  alkoxy group substituent; \n R 3  independently represents a halogen atom, cyano group, or optionally substituted C 10-30  alkoxy group; \n n represents an integer of 1 or 2; \n or a salt thereof is coupled with another compound of formula (I) and the resulting coupling product is subjected to oxidation reaction or sulfuration reaction to produce a compound represented by the following formula (IV\u2032): wherein\n R 1 , Base, Z, ring Ar, R 2 , R 3 , Q, r\u2032, and n are each as defined above; \n Y is independently as defined above; \n Pr 4  represents a hydrogen atom; and \n Base W  independently represents \n wherein each asterisk denotes the site binding to another moiety of the compound represented by the formula (IV\u2032) above to form said compound, or a base moiety selected from those represented by the above recited formulae whose amino group or imino group is protected with a protective group for the amino group or imino group of the following formula: wherein Base, Z, ring Ar, R 2 , R 3 , and n are each independently as defined above, or a salt thereof; and step (b0):\n subjecting the compound represented by the formula (IV\u2032) or the salt thereof, which is produced in step (a0), to deprotection reaction to produce the compound represented by the formula (II) or the salt thereof, with the proviso that no silyl or silyloxy substitutent moiety can include any Si\u2014H moiety therein.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 99.0
- Lexical Diversity: 1.55696
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14442601', '15118546', '13260096', '10506422', '11658533']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6134932553913477
- 35 USC 102 Novelty (BERT): 0.553340202698127
- Combined Prediction Score: 0.6074779501220257
- Mean Citation Score: 337.565162
- Max Citation Score: 420.13037
- Similarity Product: 352.40140325315423

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test