PATENT CLAIM ANALYSIS

Application Number: 15752004
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "210180"]

Abstract:
Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

Claim (Index 1):
A compound represented by Formula I or Formula Ia: wherein:\n  is a single or double bond; \n Y is a bond or NR a ; \n X is N or CR N ; wherein X is N when Y is a bond and X is CR N  when Y is NR a ; \n n is 0 or 1; \n m is 1 or 2; \n Ring A may be optionally substituted by one or two substituents each independently selected from the group consisting of halogen, hydroxyl, C 1-3 alkyl and C 1-3 alkoxy, wherein C 1-3 alkyl and C 1-3 alkoxy may optionally be substituted by one or more fluorine atoms or a substituent selected from the group consisting of cyano, hydroxyl, and N(R a R b ); \n R 1  and R 2 , together with the carbon or carbons to which they are attached, form a 4-6 membered saturated heterocyclic ring B having one or two heteroatoms selected from the group consisting of O, S(O) w  (wherein w is 0, 1 or 2) and NR h  or form a 3-6 membered saturated carbocyclic ring B; wherein the heterocyclic or carbocyclic ring B may optionally be substituted on a free carbon by one or two substituents each independently selected from the group consisting of halogen, hydroxyl, oxo, C 1-3 alkyl, C 1-3 alkoxy, \u2014C(O)\u2014NR i R j , \u2014C(O)\u2014N(R a )\u2014C 1-6 alkylene-NR i R j , \u2014C 1-6 alkylene-NR i R j , \u2014C 1-6 alkylene-O\u2014C(O)\u2014NR i R j , and \u2014O\u2014C(O)\u2014NR i R j ; wherein C 1-3 alkyl, C 1-3 alkoxy, \u2014C(O)\u2014NR i R j , \u2014C(O)\u2014N(R a )\u2014C 1-6 alkylene-NR i R j , \u2014C 1-6 alkylene-NR i R j , \u2014C 1-6 alkylene-O\u2014C(O)\u2014NR i R j , and \u2014O\u2014C(O)\u2014NR i R j  may optionally be substituted by one or more fluorine atoms or a group selected from cyano, hydroxyl, or N(R a R b ); \n R i  and R j  are selected independently for each occurrence from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, heterocyclyl and heterocyclylcarbonyl; wherein C 1-6 alkyl, C 2-6 alkenyl and C 3-6 cycloalkyl may be optionally substituted by one or more substituents independently selected from the group consisting of fluorine, hydroxyl, cyano, R a R b N\u2014, R a R b N-carbonyl- and C 1-3 alkoxy; and wherein heterocyclyl and heterocyclylcarbonyl may be optionally substituted by one or more substituents independently selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkoxy, halo-C 1-6 -alkyl, hydroxyl-C 1-6 -alkyl, R a R b N\u2014C 1-6 alkyl- and C 1-6 -alkoxy-C 1-6 -alkyl; and wherein if said heterocyclyl or heterocyclylcarbonyl contains a \u2014NH moiety that nitrogen may optionally be substituted by one or more groups independently selected from the group consisting of C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkyl-S(O) 2 \u2014 and C 1-6 -alkylcarbonyl; \n or R i  and R j  taken together with the nitrogen to which they are attached form a 4-9 membered heterocyclic ring, which may have an additional heteroatom selected from the group consisting of N, O, and S(O) w  (wherein w is 0, 1 or 2); wherein the heterocyclic ring may be optionally substituted on carbon by one, two, or more substituents selected from the group consisting of halogen, hydroxyl, oxo, cyano, C 1-6 alkyl, C 1-6 alkoxy, R a R b N\u2014, R a R b N\u2014SO 2 \u2014 and R a R b N-carbonyl-; wherein said C 1-6 alkyl and C 1-6 alkoxy may optionally be substituted the group consisting of fluorine, hydroxyl, and cyano; and wherein if said heterocyclic ring contains a \u2014NH moiety that nitrogen may be optionally substituted by a substituent selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkyl-S(O) 2 \u2014, C 1-6 alkylcarbonyl-, C 1-6 alkoxycarbonyl-, R i R j N-carbonyl- and R i R j N\u2014SO 2 \u2014; wherein C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkyl-S(O) 2 \u2014, C 1-6 alkylcarbonyl-, and C 1-6 alkoxycarbonyl- may optionally be substituted by one or more substituents selected from the group consisting of fluorine, hydroxyl, and cyano; \n R h  is independently selected for each occurrence from the group consisting of hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkyl-S(O) 2 \u2014, C 1-6 alkylcarbonyl-, C 1-6 alkoxycarbonyl-, R i R j N-carbonyl- and R i R j N\u2014SO 2 \u2014; wherein C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-6 cycloalkyl, C 1-6 alkyl-S(O) 2 \u2014, C 1-6 alkylcarbonyl-, and C 1-6 alkoxycarbonyl- may optionally be substituted by one or more substituents selected from R P ; \n R P  is independently selected, for each occurrence, from the group consisting of halogen, hydroxyl, cyano, C 1-6 alkoxy, R i R j N\u2014, R i R j N-carbonyl-, R i R j N\u2014SO 2 \u2014, and R i R j N-carbonyl-N(R a )\u2014; \n R N  is selected from the group consisting of hydrogen, halogen, hydroxyl, and C 1-6 alkyl; and \n R a  and R b  are independently selected, for each occurrence, from the group consisting of hydrogen and C 1-4 alkyl; wherein C 1-4 alkyl may optionally be substituted by one or more substituents selected from the group consisting of halogen, cyano, oxo, and hydroxyl; \n and pharmaceutically acceptable salts, stereoisomers, esters, and prodrugs thereof.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 88.0
- Lexical Diversity: 1.40625
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15827074', '15354834', '15796519', '14974033', '15769414']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8743072259904523
- 35 USC 102 Novelty (BERT): 0.616242363902765
- Combined Prediction Score: 0.8485007397816836
- Mean Citation Score: 462.634208
- Max Citation Score: 606.9383
- Similarity Product: 430.4572260581255

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test