PATENT CLAIM ANALYSIS

Application Number: 16004062
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-05
Patent Classification: ["514", "263220"]

Abstract:
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Claim (Index 1):
A compound of Formula (I) having the structure: wherein: each R 24  is each independently halogen, \u2014CN, \u2014NO 2 , \u2014OH, \u2014OCF 3 , \u2014OCH 2 F, \u2014OCF 2 H, \u2014CF 3 , \u2014SR 21 , \u2014N(R 21 )S(\u2550O) 2 R 23 , \u2014S(\u2550O) 2 N(R 21 )(R 22 ), \u2014S(\u2550O)R 23 , \u2014S(\u2550O) 2 R 23 , \u2014C(\u2550O)H, \u2014C(\u2550O)R 23 , \u2014OC(\u2550O)R 23 , \u2014CO 2 R 21 , \u2014N(R 21 )(R 22 ), \u2014C(\u2550O)N(R 21 )(R 22 ), \u2014N(R 21 )C(\u2550O)R 23 , \u2014N(R 21 )C(\u2550O)OR 22 , \u2014N(R 21 )C(\u2550O)N(R 21 )(R 22 ), substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted heteroalkyl, or substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted cycloalkyl; R 21  and R 22  are each independently H, substituted or unsubstituted C 1 -C 6 alkyl, or substituted or unsubstituted C 3 -C 8 cycloalkyl; R 23  is each independently substituted or unsubstituted C 1 -C 6 alkyl, or substituted or unsubstituted C 3 -C 8 cycloalkyl; n is 0-4; R 9  is substituted or unsubstituted heteroaryl; R 10  is H, substituted or unsubstituted C 1 -C 6 alkyl, or substituted or unsubstituted C 3 -C 8 cycloalkyl; R 6  is L-J-W; R 7  is V-Q-W; R 8  is X-A-W; or R 7  and R 8  taken together form a bond; L and J are each optionally present and when present are each independently substituted or unsubstituted C 1 -C 6  alkylene, substituted or unsubstituted C 3 -C 6  cycloalkylene, substituted or unsubstituted C 1 -C 6  heteroalkylene, substituted or unsubstituted C 2 -C 7  heterocycloalkylene, substituted or unsubstituted C 6 -C 12  arylene, substituted or unsubstituted C 3 -C 12  heteroarylene, \u2014CO\u2014, \u2014O\u2014, or \u2014S\u2014; V and Q are each optionally present and when present are each independently substituted or unsubstituted C 1 -C 6  alkylene, substituted or unsubstituted C 3 -C 6  cycloalkylene, substituted or unsubstituted C 1 -C 6  heteroalkylene, substituted or unsubstituted C 2 -C 7  heterocycloalkylene, substituted or unsubstituted C 6 -C 12  arylene, substituted or unsubstituted C 3 -C 12  heteroarylene, \u2014CO\u2014, \u2014O\u2014, or \u2014S\u2014; X and A are each optionally present and when present are each independently substituted or unsubstituted C 1 -C 6  alkylene, substituted or unsubstituted C 3 -C 6  cycloalkylene, substituted or unsubstituted C 1 -C 6  heteroalkylene, substituted or unsubstituted C 2 -C 7  heterocycloalkylene, substituted or unsubstituted C 6 -C 12  arylene, substituted or unsubstituted C 3 -C 12  heteroarylene, \u2014CO\u2014, \u2014O\u2014, or \u2014S\u2014; W is H, or NR 25 R 26 ; R 25  and R 26  are each independently H, substituted or unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 3 -C 6  cycloalkyl, substituted or unsubstituted C 1 -C 6  heteroalkyl, substituted or unsubstituted C 2 -C 7  heterocycloalkyl, substituted or unsubstituted C 6 -C 12  aryl, or substituted or unsubstituted C 3 -C 12  heteroaryl; pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 1.71154
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14902759', '13460524', '14770438', '14708099', '14081053']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7670778160227579
- 35 USC 102 Novelty (BERT): 0.5382037669172924
- Combined Prediction Score: 0.7441904111122114
- Mean Citation Score: 341.89958
- Max Citation Score: 366.60208
- Similarity Product: 234.341173123188

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test