PATENT CLAIM ANALYSIS

Application Number: 15758712
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "300000"]

Abstract:
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

Claim (Index 52):
A compound that has the structure of Formula (I), or a pharmaceutically acceptable salt or solvate thereof: wherein, R 1  and R 2  are each independently selected from H, D, F, C 1 -C 4 alkyl, and C 1 -C 4 fluoroalkyl; or R 1  and R 2  are taken together with the carbon atom to which they are attached to form a substituted or unsubstituted C 3 -C 10 cycloalkyl, or substituted or unsubstituted C 2 -C 10 heterocycloalkyl; or R 1  and R 2  are taken together with the carbon atom to which they are attached to form a carbonyl (C\u2550O); B 1  is CR B , CR 4 , or N; B 2  is CR B , CR 4 , or N; B 3  is CR B , CR 4 , or N; B 4  is CR B ; or B 4  is N if at least one of B 1 , B 2 , B 3 , or B 5  is N; B 5  is CR B  Or N; provided that at least one of B 1 , B 2 , B 3 , B 4  or B 5  is N; each R B  is independently selected from H, D, halogen, \u2014CN, \u2014OH, \u2014OR 10 , \u2014SR 10 , \u2014S(\u2550O)R 11 , \u2014S(\u2550O) 2 R 11 , \u2014N(R 10 ) 2 , \u2014NHS(\u2550O) 2 R 11 , \u2014S(\u2550O) 2 N(R 10 ) 2 , \u2014C(\u2550O)R 11 , \u2014OC(\u2550O)R 11 , \u2014CO 2 R 10 , \u2014OCO 2 R 11 , \u2014C(\u2550O)N(R 10 ) 2 , \u2014OC(\u2550O)N(R 10 ) 2 , \u2014NR 10 C(\u2550O)N(R 10 ) 2 , \u2014NR 10 C(\u2550O)R 11 , \u2014NR 10 C(\u2550O)OR 11 , substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, and substituted or unsubstituted C 1 -C 6 heteroalkyl; ring A is a monocyclic carbocycle, monocyclic heterocycle or bicyclic heterocycle; each R A  is independently selected from H, D, halogen, \u2014CN, \u2014OH, \u2014OR 10 , \u2014SR 10 , \u2014S(\u2550O)R 11 , \u2014S(\u2550O) 2 R 11 , \u2014NHS(\u2550O) 2 R 11 , \u2014S(\u2550O) 2 N(R 10 ) 2 , \u2014C(\u2550O)R 11 , \u2014OC(\u2550O)R 11 , \u2014CO 2 R 10 , \u2014OCO 2 R 11 , \u2014C(\u2550O)N(R 10 ) 2 , \u2014OC(\u2550O)N(R 10 ) 2 , \u2014NR 10 C(\u2550O)N(R 10 ) 2 , \u2014NR 10 C(\u2550O)R 11 , \u2014NR 10 C(\u2550O)OR 11 , substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, and substituted or unsubstituted C 1 -C 6 heteroalkyl; R 3  is selected from substituted or unsubstituted C 1 -C 10 alkyl, substituted or unsubstituted C 2 -C 10 alkenyl, substituted or unsubstituted C 2 -C 10 alkynyl, substituted or unsubstituted C 3 -C 10 cycloalkyl, substituted or unsubstituted C 2 -C 10 heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein if R 3  is substituted then R 3  is substituted with one or more R 12  groups;\n each R 12  is independently selected from D, halogen, \u2014CN, \u2014NO 2 , \u2014OR 10 , \u2014SR 10 , \u2014S(\u2550O)R 11 , \u2014S(\u2550O) 2 R 11 , \u2014S(\u2550O) 2 N(R 10 ) 2 , \u2014NR 10 S(\u2550O) 2 R 11 , \u2014C(\u2550O)R 11 , \u2014OC(\u2550O)R 11 , \u2014CO 2 R 10 , \u2014OCO 2 R 11 , \u2014N(R 10 ) 2 , \u2014C(\u2550O)N(R 10 ) 2 , \u2014OC(\u2550O)N(R 10 ) 2 , \u2014NR 10 C(\u2550O)R 10 , \u2014NR 10 OC(\u2550O)OR 11 , unsubstituted or substituted C 1 -C 10 alkyl, unsubstituted or substituted C 1 -C 10 fluoroalkyl, unsubstituted or substituted C 2 -C 10 alkenyl, unsubstituted or substituted C 2 -C 10 alkynyl, unsubstituted or substituted C 1 -C 10 heteroalkyl, unsubstituted or substituted C 3 -C 10 cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, and -L 4 -L 5 -R 13 ; \n L 4  is absent, \u2014O\u2014, \u2014S\u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 , \u2014NR 10 \u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550O)NH\u2014, \u2014NHC(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014OC(\u2550O)\u2014, \u2014OC(\u2550O)NH\u2014, \u2014NHC(\u2550O)NH\u2014, \u2014NHC(\u2550O)O\u2014, \u2014(CH 2 ) r \u2014, or \u2014(OCH 2 CH 2 ) r \u2014, r is 1, 2, 3, or 4; \n L 5  is absent, unsubstituted or substituted C 1 -C 10 alkylene, unsubstituted or substituted C 1 -C 10 heteroalkylene, unsubstituted or substituted C 2 -C 10 alkenylene, unsubstituted or substituted C 2 -C 10 alkynylene, unsubstituted or substituted C 3 -C 10 cycloalkylene, unsubstituted or substituted C 2 -C 10 heterocycloalkylene, unsubstituted or substituted arylene, or unsubstituted or substituted heteroarylene; \n R 13  is H, halogen, \u2014N(R 10 ) 2 , unsubstituted or substituted C 1 -C 10 alkyl, unsubstituted or substituted C 1 -C 10 alkenyl, unsubstituted or substituted C 1 -C 10 alkynyl, unsubstituted or substituted C 1 -C 10 cycloalkyl, unsubstituted or substituted C 1 -C 10 heterocycloalkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heteroaryl; \n R 4  is -L 3 -Y;\n L 3  is \u2014C(R 5 )(R 6 )\u2014, \u2014C(R 5 )(R 6 )\u2014C(R 7 )(R 8 )\u2014, \u2014O\u2014C(R 7 )(R 8 )\u2014, or \u2014C(R 5 )(R 6 )\u2014O\u2014; \n R 5  and R 7  are each independently selected from H, D, C 1 -C 4 alkyl and C 3 -C 6 cycloalkyl; \n or R 5  and R 7  are taken together with the intervening atoms to form a double bond; \n or R 5  and R 7  are taken together with the intervening atoms to form an epoxide or a substituted or unsubstituted C 3 -C 6 cycloalkyl; \n R 6  and R 8  are each independently selected from H, D, C 1 -C 4 alkyl or C 3 -C 6 cycloalkyl; \n Y is \u2014CH 2 OR 9 , \u2014C(\u2550O)OR 9 , \n R 9  is selected from H, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 heteroalkyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 3 -C 6 cycloalkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted heterocycle; L 1  is \u2014X 1 -L 2 - or -L 2 -X 1 \u2014;\n X 1  is absent, \u2014O\u2014, \u2014S\u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 \u2014, \u2014S(\u2550O) 2 NR 10 \u2014, \u2014CH 2 \u2014, \u2014CH\u2550CH\u2014, \u2014C\u2261C\u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550O)O\u2014, \u2014OC(\u2550O)\u2014, \u2014OC(\u2550O)O\u2014, \u2014C(\u2550O)NR 10 \u2014, \u2014NR 10 C(\u2550O)\u2014, \u2014OC(\u2550O)NR 10 \u2014, \u2014NR 10 C(\u2550O)O\u2014, \u2014NR 10 C(\u2550O)NR 10 \u2014, \u2014NR 10 S(\u2550O) 2 \u2014, or \u2014NR 10 \u2014; \n L 2  is absent or substituted or unsubstituted C 1 -C 4 alkylene; \n ring C is monocyclic carbocycle, bicyclic carbocycle, monocyclic N-containing heterocycle, or bicyclic heterocycle; each R C  is independently selected from H, D, halogen, \u2014CN, \u2014OH, \u2014OR 10 , \u2014SR 10 , \u2014S(\u2550O)R 11 , \u2014NO 2 , \u2014N(R 10 ) 2 , \u2014S(\u2550O) 2 R 11 , \u2014NHS(\u2550O) 2 R 11 , \u2014S(\u2550O) 2 N(R 10 ) 2 , \u2014C(\u2550O)R 11 , \u2014OC(\u2550O)R 11 , \u2014CO 2 R 11 , \u2014OCO 2 R 11 , \u2014C(\u2550O)N(R 10 ) 2 , \u2014OC(\u2550O)N(R 10 ) 2 , \u2014NR 10 C(\u2550O)N(R 10 ) 2 , \u2014NR 10 C(\u2550O)R 11 , \u2014NR 10 C(\u2550O)OR 11 , substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, substituted or unsubstituted C 1 -C 6 heteroalkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted monocyclic heteroaryl; each R 10  is independently selected from H, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, substituted or unsubstituted C 3 -C 6 cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and substituted or unsubstituted benzyl; or two R 10  on the same N atom are taken together with the N atom to which they are attached to form a N-containing heterocycle; each R 11  is independently selected from substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 1 -C 6 heteroalkyl, substituted or unsubstituted C 1 -C 6 fluoroalkyl, substituted or unsubstituted C 3 -C 6 cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and substituted or unsubstituted benzyl; n is 0, 1, or 2; p is 0, 1, 2, 3, or 4.

Metadata:
- Claim Count in Document: 354.0
- Percentile: 90.0
- Lexical Diversity: 1.54839
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15758709', '15023465', '13992053', '15695911', '15036370']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7682159565208417
- 35 USC 102 Novelty (BERT): 0.5653923457418019
- Combined Prediction Score: 0.7479335954429378
- Mean Citation Score: 334.41643399999987
- Max Citation Score: 434.08496
- Similarity Product: 354.84929087093354

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test