PATENT CLAIM ANALYSIS

Application Number: 16225920
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "210200"]

Abstract:
The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.

Claim (Index 1):
A compound of formula (I) wherein X is-CH 2 \u2014CH 2 \u2014CH 2 \u2014, \u2014CH\u2550CH\u2014CH\u2550CH\u2014, \u2014CH 2 \u2014CH 2 \u2014CH 2 \u2014CH 2 \u2014, \u2014CH 2 \u2014O\u2014CH 2 \u2014CH 2 \u2014, CH 2 \u2014CH 2 \u2014O\u2014CH 2 \u2014, \u2014CH 2 \u2014NR 2 \u2014CH 2 \u2014CH 2 \u2014, or \u2014CH 2 \u2014CH 2 \u2014NR 2 \u2014CH 2 \u2014; n is 0, 1 or 2; each R 1  is independently selected from halo, C 1-7  alkyl, C 2-7  alkenyl, hydroxy, C 1-7  alkoxy, NR 10 R 11 , and CONR 10 R 11 ;\n wherein C 1-7  alkyl and C 1-7  alkoxy are optionally substituted by one or more C 1-7  alkyl, hydroxy, C 1-7  alkoxy, NR 10 R 11  or COR 9 ; \n with the proviso that if X is \u2014CH\u2550CH\u2014CH\u2550CH\u2014 then an optional R 1  in position 8 of the phthalazin-1-onyl is fluoro; \n R 2  is H, C 1-7  alkyl, hydroxy-C 1-7  alkyl, COR 9 , CONR 10 R 11 , or SO 2 \u2014C 1-7  alkyl; Y 1  is N, CH or CCH 3 , Y 2  is N or CR 3 ;\n with the proviso that not both of Y 1  and Y 2  are N; \n R 3  is H, halogen, C 1-7  alkyl, halo-C 1-7  alkyl, CONR 10 R 11  or CO\u2014C 1-7  alkoxy; R 4  is H or C 1-7  alkyl, wherein C 1-7  alkyl is optionally substituted with one or more R 5 ; each R 5  is independently selected from hydroxy, C 1-7  alkoxy, NR 12 R 13 , COR 9 , CONR 10 R 11 , SO 2 \u2014C 1-7  alkyl, SO 2 \u2014NR 10 R 11 , heterocycloalkyl and heteroaryl;\n wherein C 1-7  alkoxy is optionally substituted by COR 9  or CONR 10 R 11 ; \n wherein heterocycloalkyl and heteroaryl are optionally substituted with one or more substituents selected from halo, C 1-7  alkyl, halo-C 1-7  alkyl, hydroxy, C 1-7  alkoxy, oxo, COR 9 , C 1-7  alkyl-COR 9  or NR 10 R 11 ; \n Z 1  is N, CH or CO\u2014CH 3 ; Z 2  is N or CH; R 6  is C 1-7  alkyl, hydroxy-C 1-7  alkyl, halo-C 1-7  alkyl, C 1-7  alkoxy-C 1-7  alkyl, C 1-7  alkoxy, halo-C 1-7  alkoxy, C 1-7  alkoxy-C 1-7  alkoxy, S-halo-C 1-7  alkyl, SF 5 , C 3-7  cycloalkyl, heterocycloalkyl or heterocycloalkyl substituted by C 1-7  alkyl; R 7  is H, halogen or C 1-7  alkyl; R 8  is H, halogen or C 1-7  alkyl; R 9  is H, C 1-7  alkyl, hydroxy, or C 1-7  alkoxy; R 10  is H or C 1-7  alkyl;\n wherein C 1-7  alkyl is optionally substituted with one or more hydroxy, C 1-7  alkoxy, COOH, or CO\u2014C 1-7  alkoxy; \n R 11  is H, C 1-7  alkyl, CO\u2014C 1-7  alkoxy or heterocycloalkyl;\n wherein C 1-7  alkyl is optionally substituted with one or more hydroxy, C 1-7  alkoxy, NH 2 , N(C 1-7  alkyl) 2 , COOH, or CO\u2014C 1-7  alkoxy; \n or R 10  and R 11  together with the interconnecting nitrogen form a heterocycloalkyl which is optionally substituted with one ore more halo, C 1-7  alkyl, halo-C 1-7  alkyl, hydroxy, C 1-7  alkoxy, oxo, COOH, CO\u2014C 1-7  alkoxy or NH 2 ; R 12  is H or C 1-7  alkyl;\n wherein C 1-7  alkyl is optionally substituted with one or more hydroxy, C 1-7  alkoxy, COOH, or CO\u2014C 1-7  alkoxy; \n R 13  is H, C 1-7  alkyl, CO\u2014C 1-7  alkoxy or heterocycloalkyl,\n wherein C 1-7  alkyl is optionally substituted with one or more hydroxy, C 1-7  alkoxy, NH 2 , N(C 1-7  alkyl) 2 , COOH, or CO\u2014C 1-7  alkoxy; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 99.0
- Percentile: 98.0
- Lexical Diversity: 1.15625
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12845045', '14458062', '13272079', '13519872', '12815800']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.764689922588929
- 35 USC 102 Novelty (BERT): 0.5162161069511111
- Combined Prediction Score: 0.7398425410251471
- Mean Citation Score: 282.042748
- Max Citation Score: 286.458
- Similarity Product: 216.7004588162899

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test