PATENT CLAIM ANALYSIS

Application Number: 16008376
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["435", "440000"]

Abstract:
Described herein are modified guide RNAs such as a single guide RNA including, from 5′ to 3′, a single-stranded protospacer sequence, a first complementary strand of a binding region for the Cas9 polypeptide, an aptamer that binds a biotin-binding molecule, and a second complementary strand of the binding region for the Cas9 polypeptide. Also described is an RNP complex including the modified guide RNA and a Cas9 polypeptide or active fragment thereof. Also included are methods of modifying target genes in cells using the modified guide RNAs.

Claim (Index 30):
A kit comprising the modified guide RNA of  claim 1 , and a Cas9 polypeptide.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 94.0
- Lexical Diversity: 1.69643
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14971356', '14319380', '14836753', '14775930', '14213723']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5798596421109474
- 35 USC 102 Novelty (BERT): 0.5431638306049801
- Combined Prediction Score: 0.5761900609603507
- Mean Citation Score: 391.502056
- Max Citation Score: 417.08105
- Similarity Product: 299.1689298744321

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test