PATENT CLAIM ANALYSIS

Application Number: 16204166
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-07
Patent Classification: ["544", "242000"]

Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Claim (Index 1):
A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n A is selected from the group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted \u2014C 3 -C 8  cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, \u2014C(O)R 1 , \u2014CO 2 R 1 , \u2014C(O)NR 1 R 2 , \u2014OR 1 , and \u2014NR 1 R 2 ; \n B is selected from the group consisting of hydrogen, CN, optionally substituted \u2014C 1 -C 6  alkyl, and optionally substituted \u2014C 3 -C 6  cycloalkyl; \n X is selected from the group consisting of optionally substituted \u2014C 3 -C 8  cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, optionally substituted aryl, and optionally substituted heteroaryl; \n Y is selected from the group consisting of hydrogen, optionally substituted \u2014C 1 -C 8  alkyl, optionally substituted \u2014C 2 -C 8  alkenyl, optionally substituted \u2014C 2 -C 8  alkynyl, optionally substituted \u2014C 3 -C 8  cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, optionally substituted aryl, optionally substituted heteroaryl, \u2014CN, \u2014C(O)R 1 , \u2014C(O)NR 1 R 2 , \u2014C(O)N(R 1 )S(O) 2 R 3 , \u2014S(O) 2 R 3 , \u2014S(O) 2 NR 1 R 2 , \u2014NR 1 R 2 , \u2014N(R 1 )C(O)R 3 , \u2014N(R 1 )C(O)NR 1 R 2 , \u2014N(R 1 )C(O)OR 3  and \u2014P(O)(OR 3 ) 2 ; \n Z is selected from the group consisting of hydrogen, C 1 -C 12  alkyl, optionally substituted \u2014C 2 -C 12  alkenyl, optionally substituted \u2014C 2 -C 12  alkynyl, optionally substituted \u2014C 3 -C 8  cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, optionally substituted aryl, optionally substituted heteroaryl, \u2014C(O)NR 1 R 2 , and \u2014C(O)OR 1 ; \n R 1  and R 2  at each occurrence are independently selected from the group consisting of hydrogen, optionally substituted \u2014C 1 -C 8  alkyl, optionally substituted \u2014C 2 -C 8  alkenyl, optionally substituted \u2014C 2 -C 8  alkynyl, optionally substituted \u2014C 3 -C 8  cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, optionally substituted aryl and optionally substituted heteroaryl; \n alternatively, R 1  and R 2  are taken together with the atom to which they are attached to form an optionally substituted 3- to 10-membered heterocyclic; and \n R 3  at each occurrence is selected from the group consisting of optionally substituted \u2014C 1 -C 8  alkyl, optionally substituted \u2014C 2 -C 8  alkenyl, optionally substituted \u2014C 2 -C 8  alkynyl, optionally substituted \u2014C 3 -C 8  cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, optionally substituted aryl and optionally substituted heteroaryl.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 98.0
- Lexical Diversity: 1.73016
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15209150', '15088517', '15216124', '16194608', '15421777']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8485426703329987
- 35 USC 102 Novelty (BERT): 0.5527238224516877
- Combined Prediction Score: 0.8189607855448675
- Mean Citation Score: 392.076462
- Max Citation Score: 423.04852
- Similarity Product: 419.7075967735911

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test