PATENT CLAIM ANALYSIS

Application Number: 15886216
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-12
Patent Classification: ["435", "070100"]

Abstract:
Disclosed is a conjugate of a protein having substantial L-asparagine aminohydrolase activity and polyethylene glycol. In particular, the polyethylene glycol has a molecular weight less than or equal to about 5000 Da and the protein is an L-asparaginase from  Erwinia . The conjugate of the invention has shown superior properties such as maintenance of a high level of in vitro activity and an unexpected increase in half-life in vivo. Also disclosed are methods of producing the conjugate and use of the conjugate in therapy. In particular, a method is disclosed for use of the conjugate in the treatment of cancer, particularly Acute Lymphoblastic Leukemia (ALL). More specifically, a method is disclosed for use of the conjugate as a second line therapy for patients who have developed hypersensitivity or have had a disease relapse after treatment with other L-asparaginase preparations.

Claim (Index 53):
The method of  claim 52 , wherein said cancer is ALL.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.78571
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15671086', '15522445', '15109304', '14706132', '14348637']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5999053014723263
- 35 USC 102 Novelty (BERT): 0.541007506007223
- Combined Prediction Score: 0.594015521925816
- Mean Citation Score: 294.1230240000001
- Max Citation Score: 411.79953
- Similarity Product: 155.39099506825627

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test