PATENT CLAIM ANALYSIS

Application Number: 16182845
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-07
Patent Classification: ["514", "063000"]

Abstract:
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Claim (Index 107):
A method for treating relapsing-remitting multiple sclerosis in a mammal comprising administering to said mammal an effective amount of a compound of formula (IIa), (IIIa) or (IIIb): or a pharmaceutically acceptable salt thereof, wherein:\n each of X 1 , X 2 , X 3 , X 4 , X 5 , and X 6 , independently, is hydrogen, halo, hydroxy, nitro, cyano, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy, cycloalkoxy, halocycloalkoxy, acyl, aminoacyl, \u2014N(R f R g ), \u2014N(R)SO 2 R g , \u2014SO 2 R f , \u2014S(O) 2 N(R f R g ), \u2014CO 2 R f , trialkylamino, aryl, or heteroaryl; \n W is \u2014O\u2014; \n Cy has the formula: \n wherein: Z 1  is \u2014CH 2 CH 2 \u2014; Z 2  is \u2014CH 2 \u2014; Z 3  is a bond; R 1a  and R 1b , independently, are hydrogen, halo, hydroxy, nitro, cyano, \u2014NR f R g , alkyl, haloalkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, alkoxy, cycloalkylalkoxy, cycloalkenylalkoxy, heterocyclylalkoxy, arylalkoxy, heteroarylalkoxy, acyl, cycloalkylacyl, cycloalkenylacyl, heterocyclylacyl, arylacyl, heteroarylacyl, thioalkyl, alkenyl, alkynyl, cycloalkenyl, heterocyclyl, aryl, or heteroaryl; or R 1a  and R 1b , when taken together, are C 2 -C 5  alkylene or C 2 -C 5  alkenylene; R 2a  and R 2b , independently, are hydrogen, halo, hydroxy, nitro, cyano, \u2014NR f R g , alkyl, haloalkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, alkoxy, cycloalkylalkoxy, cycloalkenylalkoxy, heterocyclylalkoxy, arylalkoxy, heteroarylalkoxy, acyl, cycloalkylacyl, cycloalkenylacyl, heterocyclylacyl, arylacyl, heteroarylacyl, thioalkyl, alkenyl, alkynyl, cycloalkenyl, heterocyclyl, aryl, or heteroaryl; or R 1a  and R 2a , when taken together, are C 1 -C 5  alkylene or C 2 -C 5  alkenylene; wherein R 1a , R 1b , R 2a , and R 2b  are each, independently, substituted with 0-5 substituents selected from halo, hydroxy, nitro, cyano, \u2014NR f R g , or \u2014CO 2 R f ;\n R 3  is -L 1 -J-L 2 -T 1 ; \n L 1  is \u2014C(R f R g )\u2014; \n J is \u2014N(R f )\u2014; or J is \n wherein each of D 1  and D 3 , independently, is D 2  is \u2014[C(R f R g )] k \u2014, [C(R f R g )] k \u2014N(R f )\u2014, \u2014[C(R f R g )] k \u2014O\u2014, \u2014N(R f )\u2014, or \u2014N(R f )\u2014[(CR f R g )] k \u2014; and D 4  is \u2014[C(R f R g )] m \u2014; wherein k is 1 or 2; and m is 0, 1, 2, or 3; provided that no more than 2 ring atoms of D 1 -D 4  are N or O; L 2  is \u2014C(R f R g )\u2014, \u2014C(R f R g )\u2014, \u2014C(G) 2 -, \u2014C(R f R g )\u2014C(R f R g )\u2014, \u2014C(R f R g )\u2014C(R f R g )\u2014, \u2014C(R f R g )\u2014C(G) 2 -, or a bond; T 1  is \u2014C(O)(OR f ), \u2014C(O)N(R f )S(O) 2 R f , tetrazolyl, \u2014S(O) 2 OR f , \u2014C(O)NHC(O)\u2014R f , \u2014Si(O)OH, \u2014B(OH) 2 , \u2014N(R f )S(O) 2 R f , \u2014S(O) 2 NR f , \u2014O\u2014P(O)(OR f )OR f , or \u2014P(O) 2 (OR f ); each G, independently, is hydrogen, hydroxy, a halogen, or trifluoromethyl; each R f , independently, is hydrogen, hydroxy, halo, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl or NH 2 ; wherein each of alkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl and heterocycle are optionally substituted with 1 to 5 substituents independently selected from the group consisting of halo, oxo, \u2014CN, \u2014CHO, -CG 3 , \u2014OH, \u2014NO 2 , alkyl, \u2014OCG 3 , alkoxy, cycloalkoxy, cycloalkenoxy, amino, alkylamino, dialkylamino, acylamino, aminoacyl, alkylsulfonyl, alkylaminosulfonyl, and dialkylaminosulfonyl; and each R g , independently, is hydrogen, hydroxy, halo, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, or heterocyclyl; wherein each of alkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl and heterocycle are optionally substituted with 1 to 5 substituents independently selected from the group consisting of halo, oxo, \u2014CN, \u2014CHO, -CG 3 , \u2014OH, \u2014NO 2 , alkyl, \u2014OCG 3 , alkoxy, cycloalkoxy, cycloalkenoxy, amino, alkylamino, dialkylamino, acylamino, aminoacyl, alkylsulfonyl, alkylaminosulfonyl, and dialkylaminosulfonyl.

Metadata:
- Claim Count in Document: 43.0
- Percentile: 98.0
- Lexical Diversity: 1.25926
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15783809', '15397421', '13389054', '14306231', '14874600']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8453548947273455
- 35 USC 102 Novelty (BERT): 0.6099373445531988
- Combined Prediction Score: 0.8218131397099309
- Mean Citation Score: 540.187412
- Max Citation Score: 542.35815
- Similarity Product: 535.5724404668927

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test