PATENT CLAIM ANALYSIS

Application Number: 15771043
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-02
Patent Classification: ["514", "021300"]

Abstract:
The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

Claim (Index 44):
A method of derivatizing a polypeptide that comprises a free amino group, the method comprising contacting the derivatized amino acid of  claim 43  with the polypeptide under conditions under which the free carboxylic acid of the derivatized amino acid forms an amide bond with the free amino acid of the polypeptide.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 91.0
- Lexical Diversity: 1.59524
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12845455', '13130962', '14182706', '13697021', '12066324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7473946466397281
- 35 USC 102 Novelty (BERT): 0.5069425838304928
- Combined Prediction Score: 0.7233494403588047
- Mean Citation Score: 258.376928
- Max Citation Score: 264.86304
- Similarity Product: 181.91410942365647

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test