PATENT CLAIM ANALYSIS

Application Number: 16087918
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-10
Patent Classification: ["544", "280000"]

Abstract:
The present invention belongs to the field of pharmaceutical chemistry, and relates to a substituted pyrrolopyrimidine CDK inhibitor, in particular to a compound as shown in formula I or a pharmaceutically acceptable salt or solvate thereof, as well as a preparation method thereof and a pharmaceutical composition thereof. The present invention also relates to the use of the compound and the pharmaceutical composition thereof in the preparation of a drug for treating diseases associated with CDK inhibition. The compound according to the present invention has a marked inhibitory effect on CDK, excellent drug absorption and significantly superior oral absorption effect.

Claim (Index 1):
A compound of Formula III or a pharmaceutically acceptable salt or solvate thereof, wherein R 1  is selected from the group consisting of \u2014S(O) 2 R 4  and \u2014C(O)NR 5 R 6 ; R 4  is selected from the group consisting of hydrogen, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, 3- to 6-membered heterocycloalkyl, 5- to 10-membered aryl, and 5- to 10-membered heteroaryl, which are optionally substituted by one or more R a ; R 5  and R 6  are independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, 3- to 6-membered heterocycloalkyl, 5- to 10-membered aryl, and 5- to 10-membered heteroaryl, which are optionally substituted by one or more R a ; the group is when the group is Y is selected from the group consisting of CH and N; and when the group is Y is C;\n W is selected from the group consisting of O, S, CR 7 R 8  and NR 9 ; \n R 7  and R 8  are independently selected from the group consisting of hydrogen, \u2014NR 10 R 11 , C 1-6  alkyl, C 3-6  cycloalkyl, 5- to 10-membered aryl, and 5- to 10-membered heteroaryl, which are optionally substituted by one or more R a ; \n R 10  and R 11  are independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-6  cycloalkyl, 5- to 10-membered aryl, and 5- to 10-membered heteroaryl, which are optionally substituted by one or more R a ; \n R 9  is selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-6  cycloalkyl, 5- to 10-membered aryl, and 5- to 10-membered heteroaryl, which are optionally substituted by one or more R a ; \n R a  is selected from the group consisting of halogen, cyano, \u2014R, \u2014OR, \u2550O, \u2014SR, \u2014NR 2 , \u2550NR, \u2014C(halogen) 3 , \u2014CR(halogen) 2 , \u2014CR 2 (halogen), \u2014OCN, \u2014SCN, \u2014N\u2550C\u2550O, \u2014NCS, \u2014NO, \u2014NO 2 , \u2014NRC(\u2550O)R, \u2014NRC(\u2550O)OR, \u2014NRC(\u2550O)NRR, \u2014C(\u2550O)NRR, \u2014C(\u2550O)OR, \u2014OC(\u2550O)NRR, \u2014OC(\u2550O)OR, \u2014C(\u2550O)R, \u2014S(\u2550O) 2 OR, \u2014S(\u2550O) 2 R, \u2014OS(\u2550O) 2 OR, \u2014S(\u2550O) 2 NRR, \u2014S(\u2550O)R, \u2014NRS(\u2550O) 2 R, \u2014NRS(\u2550O) 2 NRR, \u2014NRS(\u2550O) 2 OR, \u2014OP(\u2550O)(OR) 2 , \u2014P(\u2550O)(OR) 2 , \u2014C(\u2550O)R, \u2014C(\u2550S)R, \u2014C(\u2550O)OR, \u2014C(\u2550S)OR, \u2014C(\u2550O)SR, \u2014C(\u2550S)SR, \u2014C(\u2550O)NRR, \u2014C(\u2550S)NRR, \u2014C(\u2550NR)NRR and \u2014NRC(\u2550NR)NRR; and R is independently selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-6  cycloalkyl, 3- to 6-membered heterocycloalkyl, 5- to 10-membered aryl and 5- to 10-membered heteroaryl, wherein when R a  is \u2014R, R is not hydrogen; and \n provided that: when R 1  is selected from \u2014C(O)NR 5 R 6 , the group \n is and Y is C.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.91071
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15566872', '13497067', '14158358', '13060154', '15546165']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8076848125962107
- 35 USC 102 Novelty (BERT): 0.534437375263993
- Combined Prediction Score: 0.7803600688629889
- Mean Citation Score: 350.99347400000005
- Max Citation Score: 367.805
- Similarity Product: 284.3215306296945

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test