PATENT CLAIM ANALYSIS

Application Number: 16254127
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-08
Patent Classification: ["536", "026140"]

Abstract:
The present disclosure relates to the field of nucleic acid chemistry, specifically to 5-position modified uridines as well as phosphoramidite and triphosphate derivatives thereof. The present disclosure also relates to methods of making and using the same.

Claim (Index 5):
An aptamer comprising at least one modified nucleotide having the following structure: wherein R is selected from the group consisting of \u2014(CH 2 ) n \u2014R X1 ; R X1  is selected from the group consisting of: *Denotes point of attachment of the R X1  group to (CH 2 ) n  connecting group wherein R X4  is selected from the group consisting of a branched or linear lower alkyl (C1-C20); halogen (F, Cl, Br, I); nitrile (CN); boronic acid (BO 2 H 2 ); carboxylic acid (COOH); carboxylic acid ester (COOR X2 ); primary amide (CONH 2 ); secondary amide (CONHR X2 ); tertiary amide (CONR X2 R X3 ); sulfonamide (SO 2 NH 2 ); N-alkylsulfonamide (SONHR X2 ); wherein R X2  and R X3  are independently selected from the group consisting of a branched or linear lower alkyl (C1-C20); phenyl (C 6 H 5 ); an R X4  substituted phenyl ring (R X4 C 6 H 4 ), wherein R X4  is defined above; a carboxylic acid (COOH); a carboxylic acid ester (COOR X5 ), wherein R X5  is a branched or linear lower alkyl (C1-C20); and cycloalkyl; wherein n=2-10; wherein X is selected from the group consisting of \u2014H, \u2014OH, \u2014OMe, \u2014O-allyl, \u2014F, \u2014OEt, \u2014OPr, \u2014OCH 2 CH 2 OCH 3  and -azido.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 99.0
- Lexical Diversity: 1.37931
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15914050', '14917056', '15650281', '14069798', '14216486']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.648845497843023
- 35 USC 102 Novelty (BERT): 0.5339336356533463
- Combined Prediction Score: 0.6373543116240554
- Mean Citation Score: 379.661352
- Max Citation Score: 450.5075
- Similarity Product: 366.8764256548882

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test