PATENT CLAIM ANALYSIS

Application Number: 16324576
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["435", "006110"]

Abstract:
A method of diagnosing a disease associated with a DNA repeat sequence is disclosed. The method comprises: (a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject; and (b) determining the CpG methylation status of the DNA molecules, wherein the number of repeats of the DNA sequence and the CpG methylation status of the DNA molecules is indicative of the disease.

Claim (Index 35):
A method of analyzing the methylation status of a CpG site along a DNA molecule comprising:\n (a) contacting the DNA with a methyltransferase enzyme in the presence of a co-factor which is labeled with a detectable moiety under conditions which brings about transfer of said detectable moiety from said co-factor to said DNA; (b) extending the DNA molecule; and (c) detecting said detectable moiety, wherein the presence of the detectable moiety is indicative of a non-methylated CpG site and wherein the method further comprises attaching to the DNA molecule an additional detectable moiety which labels a sequence of said DNA which is not a CpG site using a DNA labeling agent and wherein said DNA labeling agent is a sequence-specific DNA labeling agent.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 99.0
- Lexical Diversity: 2.19444
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11570672', '11330370', '11719033', '14578125', '14773826']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.612269444999288
- 35 USC 102 Novelty (BERT): 0.5055805211276205
- Combined Prediction Score: 0.6016005526121213
- Mean Citation Score: 273.681804
- Max Citation Score: 294.7531
- Similarity Product: 227.2664543872237

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test