PATENT CLAIM ANALYSIS

Application Number: 15915983
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["536", "004100"]

Abstract:
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.

Claim (Index 61):
A deoxyribonucleic acid having attached by a phosphodiester bond at its 3\u2032 end, a deoxyribonucleotide analog having any one of the following structures: wherein the O \u03b1  is the O atom at the 3\u2032 end of the deoxyribonucleic acid, and the wavy line represents the remainder of the deoxyribonucleic acid that is 5\u2032 relative to the O \u03b1  atom; wherein R (a) represents a small, chemically cleavable, chemical group capping the oxygen at the 3\u2032 position of the deoxyribose of the deoxyribonucleotide analogue, and (b) does not contain a ketone group; wherein OR is not a methoxy group or an ester group; wherein tag represents a detectable fluorescent moiety; wherein Y represents a chemically cleavable, chemical linker; wherein the deoxyribonucleic acid: i) produces a 3\u2032-OH group on the deoxyribose of the deoxyribonucleotide analog upon cleavage of R, and ii) no longer includes a tag on the base upon cleavage of Y and wherein if the deoxyribonucleotide analogue is: (A), it is capable of forming hydrogen bonds with cytosine or a cytosine nucleotide analogue; (B), it is capable of forming hydrogen bonds with thymine or a thymine nucleotide analogue; (C), it is capable of forming hydrogen bonds with guanine or a guanine nucleotide analogue; or (D), it is capable of forming hydrogen bonds with adenine or an adenine nucleotide analogue.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.53846
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['10702203', '14670748', '11894690', '15647657', '15167917']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5856610364112064
- 35 USC 102 Novelty (BERT): 0.5521042456524686
- Combined Prediction Score: 0.5823053573353326
- Mean Citation Score: 450.836768
- Max Citation Score: 451.2284
- Similarity Product: 319.33759938113684

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test