PATENT CLAIM ANALYSIS

Application Number: 15767676
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "275000"]

Abstract:
Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Claim (Index 1):
A compound of Formula (I): wherein R 3a  and R 3b  are independently selected from hydrogen and substituted or unsubstituted C 1 -C 6  alkyl; L 1  is selected from a (CH 2 ) n , (CH 2 ) n C(O), (CH 2 ) n C(O)O, (CH 2 ) n C(O)(NR 3c ), (CH 2 ) n SO 2 , and (CH 2 ) n P(O)(N(R 3c )); Q 1  is selected from substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, and poly(ethylene oxide), or wherein, when substituted, one or more substituents on Q 1  forms a ring with R 3b ; R 5a , R 5b , R 5c , R 5d , and R 5e  are independently selected from hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 3 -C 10  cycloalkyl, halogen, hydroxy, carboxyl, amino, nitro, cyano, isocyano, -L 2 Q 2 ; wherein said C 1 -C 6  alkyl, C 1 -C 6  alkoxy and C 3 -C 10  cycloalkyl groups are optionally substituted one or more times with a group selected from halogen, hydroxy, carboxyl, amino, nitro, cyano, isocyano, and combinations thereof; or wherein any two of R 5a , R 5b , R 5c , R 5d , R 5e , and R 3a , together form a ring; L 2  is selected from (CH 2 ) n , (CH 2 ) n O, (CH 2 ) n S, (CH 2 ) n S(O), (CH 2 ) n SO 2 , (CH 2 ) n N(R 3c ), (CH 2 ) n C(O), (CH 2 ) n N(R 3c )C(O), (CH 2 ) n OC(O), (CH 2 ) n C(O)O, (CH 2 ) n C(O)N(R 3c ), (CH 2 ) n N(R 3c )C(O)N(R 3c ), (CH 2 ) n SO 2 N(R 3c ), (CH 2 ) n N(R 3c )SO 2 , (CH 2 ) n N(R 3c )P(O)(R 3c ), and (CH 2 ) n P(O)N(R 3c ); R 3c  is in each case independently selected from hydrogen and substituted or unsubstituted C 1 -C 6  alkyl; Q 2  is selected from substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted heterocyclyl or poly(ethylene oxide); or wherein two or more substituents on Q 2  form a ring may together with R 3a  form a ring; and n in each case is independently selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10; or a salt thereof.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 91.0
- Lexical Diversity: 1.43333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15501613', '15619671', '14204076', '14977508', '14633360']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7371612868423051
- 35 USC 102 Novelty (BERT): 0.5418179848472252
- Combined Prediction Score: 0.7176269566427971
- Mean Citation Score: 311.770436
- Max Citation Score: 366.1146
- Similarity Product: 292.61637636376616

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test