PATENT CLAIM ANALYSIS

Application Number: 15756367
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "300000"]

Abstract:
The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

Claim (Index 9):
A compound according to 8\n or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, or a solvate thereof, wherein: R 1  is independently selected from: cyclobutyl, cyclopentyl, cyclohexylmethyl, Ph, Bn, phenethyl, 2-F-Ph, 3-F-Ph, 4-F-Ph, 3-Cl-Ph, 3-Br-Ph, 4-Br-Ph, 2-Me-Ph, 3-Me-Ph, 4-Me-Ph, 2-OMe-Ph, 3-OMe-Ph, 4-OMe-Ph, 3-CF 3 -Ph, 3-cyclopropyl-Ph, 3-Me-4-F-Ph, 3-biphenyl, 3-Bn-Ph, 3-OBn-Ph, 4-OBn-Ph, 3-CH 2 OPh-Ph, 2-Me-Bn, 2-t-Bu-Bn, 3-t-Bu-Bn, 4-t-Bu-Bn, 2-Cl\u2014Bn, 4-Cl\u2014Bn, 3-Br-Bn, 3-OMe-Bn, 4-OMe-Bn, 3-CF 3 \u2014Bn, 4-CF 3 \u2014Bn, 3-OCHF 2 \u2014Bn, 4-OCHF 2 \u2014Bn, 3-OCF 3 \u2014Bn, 4-CH 2 OH-Bn, 4-CO 2 H-Bn, 3-CN-Bn, 4-CN-Bn, 3-NH 2 \u2014Bn, 3-CH 2 NH 2 \u2014Bn, 4-CH 2 NH 2 \u2014Bn, 3-CH 2 N(Me) 2 -Bn, 4-CONH 2 \u2014Bn, 4-(CONH(Pr))-Bn, 4-(CONH(CH 2 ) 2 OH)-Bn, 4-(CONHCH(Me)CH 2 OH)-Bn, 4-(CONH(CH 2 ) 2-3 N(Me) 2 )-Bn, 4-(CON(Me)(CH 2 ) 2 N(Me) 2 )-Bn, 4-(CONHCH 2 CONH 2 )-Bn, 3-SO 2 Me-Bn, 4-SO 2 Me-Bn, 3-Ph-Bn, 4-Ph-Bn, 4-(3-CN-Ph)-Bn, 3-(4-OCF 3 -Ph)-Bn, 3-Bn-Bn, 3-OPh-Bn, 2-OBn-Bn, 3-OBn-Bn, 4-(1H-pyrazol-1-yl)-Bn, 3-(1-Me-1H-pyrazol-3-yl)-Bn, 3-(5-Me-1,2,4-oxadiazol-3-yl)-Bn, 3-(pyrid-2-yl)-Bn, 3-(pyrid-3-yl)-Bn, 4-(6-OMe-pyrid-3-yl)-Bn, 3-(2-OMe-pyrimidin-5-yl)-Bn, 2-Cl-4-Cl-Ph, 3-Br-4-F-Ph, 3-F-4-CN-Bn, 3-Br-5-CN-Bn, 3-Cl-5-Ph-Bn, \u2014CH(Me)-Ph, \u2014CH((CH 2 ) 1-3H)-Ph, \u2014CH((CH 2 )O(Si(Me) 2 (t-Bu))-Ph, 1H-pyrrolidin-3-yl, 5-Ph-1,2-oxazol-3-ylmethyl, 4-Ph-imidazol-2-ylmethyl, 1-(pyrid-2-yl)-1H-pyrazol-4-ylmethyl, 2-(4-Cl \u2212  Ph)-4-Me-thiazol-5-ylmethyl, 1-Ph-1H-1,2,3-triazol-4-ylmethyl, 1-Bn-1H-1,2,3-triazol-4-ylmethyl, 3-Ph-1,2,4-oxadiazol-5-ylmethyl, 2-Ph-5-Me-2H-1,2,3-triazol-4-ylmethyl, pyrid-2-yl, pyrid-3-yl, 5-F-pyrid-2-yl, 5-F-pyrid-3-yl, 4-Me-pyrid-2-yl, 6-Me-pyrid-2-yl, 2-OMe-pyrid-4-yl, pyrid-3-ylmethyl, 6-OMe-pyrid-3-ylmethyl, 5-Ph-pyrid-3-ylmethyl, 6-Ph-pyrid-2-ylmethyl, naphth-1-yl, naphth-2-yl, 4-Me-naphth-1-yl, 7-OMe-naphth-1-yl, naphth-1-ylmethyl, naphth-2-ylmethyl, 6-OH-naphth-2-ylmethyl, 6-O(CH 2 ) 2 N(Me) 2 -naphth-2-ylmethyl, quinolin-8-yl, quinolin-6-ylmethyl, isoquinolin-4-yl, isoquinolin-6-yl, isoquinolin-6-ylmethyl, 3-OMe-isoquinolin-6-ylmethyl, 1-OMe-isoquinolin-7-ylmethyl, 3-OMe-isoquinolin-7-ylmethyl, and\n R 3  is independently selected from: Me and CF 3 .

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.26829
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15756373', '15756378', '16099010', '13944921', '13936311']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8020915531323982
- 35 USC 102 Novelty (BERT): 0.5976846480674092
- Combined Prediction Score: 0.7816508626258993
- Mean Citation Score: 444.768054
- Max Citation Score: 554.2722
- Similarity Product: 418.3051024918557

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test