PATENT CLAIM ANALYSIS

Application Number: 15990176
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["800", "008000"]

Abstract:
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.

Claim (Index 1):
A method of generating a non-human homozygous knockout organism, the method comprising,\n (a) introducing an exogenous sequence into a cell using a nuclease that mediates targeted integration of the exogenous sequence into a selected locus of the genome of the organism, the locus comprising at least first and second alleles; (b) identifying cells comprising (i) the exogenous sequence in the first allele of the target locus and (ii) a non-homologous end joining (NHEJ) modification in the second allele of the selected target locus; (c) allowing the cells identified in step (b) to develop into reproductively mature organisms; (d) crossing the reproductively mature organisms to each other; and (e) identifying progeny that exhibit NHEJ modifications at the first and second alleles of the selected target locus, thereby generating a homozygous organism lacking exogenous sequences at the selected target locus.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 93.0
- Lexical Diversity: 1.15385
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13234007', '13794199', '12284887', '14807183', '15935908']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.634131367082553
- 35 USC 102 Novelty (BERT): 0.5073482163121127
- Combined Prediction Score: 0.6214530520055089
- Mean Citation Score: 316.629834
- Max Citation Score: 327.7687
- Similarity Product: 262.03259033504725

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test