PATENT CLAIM ANALYSIS

Application Number: 15902437
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "043000"]

Abstract:
The present invention relates to a prodrug of 5-azacytidine or 2′-deoxy-5-azacytidine having remarkable stability against cytidine deaminase, a metabolic hydrolyzing enzyme in replacement of current injections (5-azacytidine or 2′-deoxy-5-azacytidine) which are clinically used as therapeutic agents for various myelomas including myelodysplastic syndrome. The present invention provides a compound represented by formula (1), or salt thereof, wherein, R is OR 3  or a hydrogen atom, R 1 , R 2 , and R 3  are each independently hydrogen atom or silyl group represented by formula (2): wherein, R 4 , R 5 , and R 6  are each independently alkyl group which may have a substituent, aryl group which may have a substituent, or arylalkyl group which may have a substituent, with the provision that R 1 , R 2 , and R 3  are not hydrogen atom simultaneously.

Claim (Index 12):
A method for treatment of a symptom, which is selected from the group consisting of hematological abnormality, benign tumors, primary and metastatic tumors, restenosis, abnormal stimulation to endothelial cells, damage in body tissue caused by surgery, abnormal wound healing, abnormal angiogenesis, repetitive dyskinesia, high level angiodysplasia, and productive response followed by organ transplantation, the method comprising administering to a patient in need thereof the compound or salt thereof of  claim 1 .

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 2.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15355315', '15355326', '11815149', '11887159', '14057004']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7672883005033198
- 35 USC 102 Novelty (BERT): 0.5844602778029375
- Combined Prediction Score: 0.7490054982332816
- Mean Citation Score: 316.272016
- Max Citation Score: 485.39816
- Similarity Product: 450.0542686047172

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test