PATENT CLAIM ANALYSIS

Application Number: 15753008
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "406000"]

Abstract:
Disclosed herein is a compound of formula (I) and/or a pharmaceutically acceptable salt thereof that can serve as Erk inhibitors. They are potentially useful in the treatment of diseases treatable by inhibition of Erk, such as cancers. Also disclosed herein is a pharmaceutical composition, comprising a compound of formula I and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

Claim (Index 1):
A compound of formula I: and/or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is H or alkyl, \n R 2  is aryl, heteroaryl, cycloalkyl, alkyl, alkoxy, or heterocycloalkyl, wherein each of the aryl, heteroaryl, cycloalkyl, alkyl, alkoxy, and heterocycloalkyl is optionally substituted with at least one group chosen from halo, hydroxyl, \u2014CN, \u2014CO 2 H, \u2014CONR 3 R 4 , \u2014SO 2 NR 3 R 4 , oxo, alkyl optionally substituted with at least one group chosen from halo and alkoxy, and alkoxy optionally substituted with at least one group chosen from halo and alkoxy, \n R 3  and R 4  are independently chosen from H and alkyl optionally substituted with at least one alkoxy, or R 3  and R 4 , together with the nitrogen to which they are attached form a heterocyclyl ring, \n B ring is an aryl or heteroaryl wherein each of the aryl and heteroaryl is optionally substituted with at least one group chosen from alkyl, alkoxy, halo, and \u2014CN, \n R 5  is independently chosen from H and alkyl optionally substituted with at least one alkoxy, \n L 1  is\n (CR\u2032R\u2033)n wherein n is 1, 2, or 3, R\u2032 and R\u2033 independently are chosen from H and alkyl optionally substituted with at least one group chosen from hydroxyl and halo, \n aryl optionally substituted with at least one group chosen from halo, \u2014SO 2 alkyl, and alkyl, wherein the alkyl is optionally substituted with at least one group chosen from halo, hydroxyl, and alkoxy, \n heteroaryl optionally substituted with at least one group chosen from halo, \u2014SO 2 alkyl, and alkyl, wherein the alkyl is optionally substituted with at least one group chosen from halo, hydroxyl, and alkoxy, \n cycloalkyl optionally substituted with at least one group chosen from halo, \u2014SO 2 alkyl and alkyl, wherein the alkyl is optionally substituted with at least one group chosen from halo, hydroxyl and alkoxy, or \n heterocycloalkyl optionally substituted with at least one group chosen from halo, \u2014SO 2 alkyl, and alkyl, wherein the alkyl is optionally substituted with at least one group chosen from halo, hydroxyl, and alkoxy, \n \n L 2  is\n aryl optionally substituted with at least one group chosen from halo, \u2014SO 2 alkyl, and alkyl, wherein the alkyl is optionally substituted with at least one group chosen from halo, hydroxyl, and alkoxy, \n heteroaryl optionally substituted with at least one group chosen from halo, \u2014SO 2 alkyl, and alkyl, wherein the alkyl is optionally substituted with at least one group chosen from halo, hydroxyl, and alkoxy, \n cycloalkyl optionally substituted with at least one group chosen from halo, \u2014SO 2 alkyl and alkyl, wherein the alkyl is optionally substituted with at least one group chosen from halo, hydroxyl and alkoxy, \n heterocycloalkyl optionally substituted with at least one group chosen from halo, \u2014SO 2 alkyl, and alkyl, wherein the alkyl is optionally substituted with at least one group chosen from halo, hydroxyl, and alkoxy, or \n \n with   indicating the point of attachment to the neighboring group,\n L 3  is \n H,\n aryl optionally substituted with at least one group chosen from halo; alkyl optionally substituted with at least one group chose from halo and alkoxy; aryl; heteroaryl; cycloalkyl; and heterocycloalkyl; wherein each of the last four groups: aryl, heteroaryl, cycloalyl, and heterocycloalkyl, is optionally substituted with at least one group chosen from alkyl, halo, aryl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, cycloalkyl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, heterocycloalkyl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, and heteroaryl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, \n heteroaryl optionally substituted with at least one group chosen from halo; alkyl optionally substituted with at least one group chose from halo and alkoxy; aryl; eteroaryl; cycloalkyl; and heterocycloalkyl; wherein each of the last four groups: aryl, heteroaryl, cycloalyl, and heterocycloalkyl, is optionally substituted with at least one group chosen from alkyl, halo, aryl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, cycloalkyl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, heterocycloalkyl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, and heteroaryl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, \n cycloalkyl optionally substituted with at least one group chosen from halo; alkyl optionally substituted with at least one group chose from halo and alkoxy; aryl; heteroaryl; cycloalkyl; and heterocycloalkyl; wherein each of the last four groups: aryl, heteroaryl, cycloalyl, and heterocycloalkyl, is optionally substituted with at least one group chosen from alkyl, halo, aryl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, cycloalkyl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, heterocycloalkyl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, and heteroaryl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, or \n heterocycloalkyl optionally substituted with at least one group chosen from halo; alkyl optionally substituted with at least one group chose from halo and alkoxy; aryl; heteroaryl; cycloalkyl; and heterocycloalkyl; wherein each of the last four groups: aryl, heteroaryl, cycloalyl, and heterocycloalkyl, is optionally substituted with at least one group chosen from alkyl, halo, aryl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, cycloalkyl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, heterocycloalkyl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, and heteroaryl optionally substituted with at least one group chosen from halo, alkyl and alkoxy, \n \n provided that (1) when B is aryl and L 1  is a heterocycloalkyl, the heterocycloalkyl is pyrrolidinyl.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 1.5814
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15352184', '14776280', '14135793', '14710631', '13855246']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8248721232945381
- 35 USC 102 Novelty (BERT): 0.5494068736708061
- Combined Prediction Score: 0.7973255983321649
- Mean Citation Score: 402.434838
- Max Citation Score: 408.44528
- Similarity Product: 355.1285805680276

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test