PATENT CLAIM ANALYSIS

Application Number: 16146807
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["435", "006100"]

Abstract:
Provided herein is a method of sequencing hydroxymethyated cell-free DNA. In some embodiments, the method comprises adding an affinity tag to only hydroxymethyated DNA molecules in a sample of cfDNA, enriching for the DNA molecules that are tagged with the affinity tag; and sequencing the enriched DNA molecules.

Claim (Index 6):
The method of  claim 5 , further comprising, after step (a)(iii) and prior to step (a)(iv), washing the support and setting up an amplification reaction containing the support, without releasing the biotinylated DNA molecules from the support.

Metadata:
- Claim Count in Document: 54.0
- Percentile: 97.0
- Lexical Diversity: 1.47222
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14983379', '13555037', '13009718', '12958353', '13600043']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5449356241332681
- 35 USC 102 Novelty (BERT): 0.5236802396707795
- Combined Prediction Score: 0.5428100856870193
- Mean Citation Score: 238.7877
- Max Citation Score: 248.1314
- Similarity Product: 108.39976184901596

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test