PATENT CLAIM ANALYSIS

Application Number: 15889368
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "193000"]

Abstract:
Provided herein are engineered systems and methods for establishing DNA adenine methylation at specific genomic locations and using DNA adenine methylation as an artificial chemical “handle” on the genome. These systems and methods allow for placing the handle on specific genomic locations as well as molecular technologies to bind, spatially spread, and maintain the handle. The systems described herein comprise, in some embodiments, three functional modules that mediate m6A operations: (1) a synthetic initiator module to place m6A at specific genomic sites; (2) a synthetic readout module to program m6A recognition and m6A-dependent transcriptional logic; and (3) propagation module that implements “read-write,” a mechanism proposed to underlie chromatin spreading and epigenetic maintenance across cellular systems.

Claim (Index 19):
The engineered DNA methylation system of  claim 1 , wherein the writer fusion protein further comprises a linker sequence between the DNA binding protein or domain thereof and the mutant DNA adenine methyltransferase.

Metadata:
- Claim Count in Document: 55.0
- Percentile: 88.0
- Lexical Diversity: 1.61905
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15686419', '13353662', '14105017', '14775869', '14897048']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5268630024771946
- 35 USC 102 Novelty (BERT): 0.5149262589825508
- Combined Prediction Score: 0.5256693281277303
- Mean Citation Score: 276.62375000000003
- Max Citation Score: 290.01645
- Similarity Product: 221.0815319666952

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test