PATENT CLAIM ANALYSIS

Application Number: 16023167
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-11
Patent Classification: ["548", "462000"]

Abstract:
A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20≤n≤2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.

Claim (Index 1):
A polyethylene glycol bonded substance, comprising a bio functional molecule bonded to an end of a branched hetero polyethylene glycol represented by the formula [1]: wherein X represents an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and Y represents an atomic group consisting essentially of a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and a bonding moiety to be bonded to a branching linker moiety E selected from the group consisting of an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a saturated hydrocarbon group containing a secondary amino group, a single bond, and a saturated hydrocarbon group, and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; wherein as a combination of the functional group X and the functional group Y: Y is a group selected from a maleimide group, a vinylsulfone group, an iodoacetamide group, an active carbonate group, an amino group, and an aminoxy group when X is an acetal group, Y is a group selected from a maleimide group, a vinylsulfone group, an acetylene group, and an azide group when X is an aldehyde group, Y is a group selected from an acetal group, an active ester group, an active carbonate group, an acetylene group, and an azide group when X is a maleimide group, a vinylsulfone group, or an iodoacetamide group, Y is a group selected from an acetal group, a maleimide group, a vinylsulfone group, an iodoacetamide group, an acetylene group, and an azide group when X is an active ester group or an active carbonate group, Y is a group selected from an acetal group, an acetylene group, and an azide group when X is an amino group or an aminoxy group, Y is a group selected from an acetal group, an aldehyde group, a maleimide group, a vinylsulfone group, an iodoacetamide group, an active ester group, an active carbonate group, an amino group, and an aminoxy group when X is an acetylene group or an azide group, wherein the active ester group is a group represented by the following formula [9] which is reactive with nucleophilic groups: wherein R2 is a phenyl group, a 3-pyridyl group, a succinimide group, a 2-benzothiazole group, or a 1-benzotriazole group and W and W\u2032 are each independently a linker comprising a covalent bond selected from the group consisting of an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a saturated hydrocarbon group containing a secondary amino group, a single bond, and a saturated hydrocarbon group; s is an integer of 2 or 4, which represents a number of polyethylene glycol chains; n is a number of average added moles for the polyethylene glycol chain and 20\u2264n\u22642000; and E is a branching linker moiety represented by the formula [A] or [B]: wherein each D is \u2014(CH2)a-O\u2014(CH2)b-, \u2014(CH2)a-O\u2014C(O)\u2014NH\u2014(CH2)b-, \u2014O\u2014C(O)\u2014NH\u2014(CH2)b, \u2014(CH2)a-NH\u2014C(O)\u2014O\u2014(CH2)b-, \u2014(CH2)a-C(O)\u2014NH(CH2)b, or \u2014(CH2)a-NH\u2014C(O)\u2014(CH2)b, or a single bond, a=1-12, b=1-12, v=0 or 2, and w=0 or 1.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 94.0
- Lexical Diversity: 1.87671
- Patent Class: 548.0
- Transitional Phrase Type: half
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13167777', '16010972', '15738761', '13324872', '10960674']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7217357266206559
- 35 USC 102 Novelty (BERT): 0.5669372728053846
- Combined Prediction Score: 0.7062558812391287
- Mean Citation Score: 284.627842
- Max Citation Score: 423.42548
- Similarity Product: 404.01988543818464

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test