PATENT CLAIM ANALYSIS

Application Number: 16215029
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["514", "265100"]

Abstract:
The present invention relates to a liquid pharmaceutical composition suitable for parenteral administration comprising: a) pemetrexed diacid; b) at least one organic amine; c) at least one antioxidant; d) 10-200 mg/ml of propylene glycol; and e) one or more parenteral solvents, wherein the preparation thereof is conducted in an atmosphere of inert gas and wherein the organic amine(s) is present in an amount sufficient to reach a pH of the composition in the range from 8.3 to 9.1

Claim (Index 25):
A ready to use liquid pemetrexed pharmaceutical composition that was made by a process, which comprises:\n a) dissolving pemetrexed diacid into an aqueous solution that contains one or more amines, wherein at least one amine is arginine, to form a pemetrexed solution; b) dissolving at least one monothiolic antioxidant and optionally a chelating agent into said pemetrexed solution to form an antioxidant solution; c) dissolving propylene glycol into said antioxidant solution to form a liquid composition; and d) optionally adding water to said liquid composition;\n wherein said dissolving steps (a)-(c) are carried out under an atmosphere of inert gas; \n wherein said liquid composition has a pH in the range of 8.3 to 9.1; said propylene glycol is present in said liquid composition in a concentration of 10 to 200 mg/ml; and said liquid composition is free from pemetrexed disodium.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 98.0
- Lexical Diversity: 1.53333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15990035', '15200433', '14403310', '15561118', '13806624']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7790051629633543
- 35 USC 102 Novelty (BERT): 0.5419927605636666
- Combined Prediction Score: 0.7553039227233855
- Mean Citation Score: 239.714058
- Max Citation Score: 385.4432
- Similarity Product: 299.66675409660337

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test