PATENT CLAIM ANALYSIS

Application Number: 16036375
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "179000"]

Abstract:
The invention provides inhibitors of α-crystallin aggregation and methods of using α-crystallin aggregation inhibitors to, e.g., treat or prevent cataracts in a subject having or at risk of developing cataracts. The invention further provides high throughput methods of screening compounds for modulation of protein thermal stability, the method comprising contacting a protein with each of a plurality of test compounds; and (b) measuring the melting transition (T m ) of the protein in the presence of each of the plurality of test compounds, wherein a compound that decreases or increases the apparent T m  by at least 2 standard deviations is identified as a pharmacological protein chaperone.

Claim (Index 20):
The method of any one of  claims 15 - 19 , wherein the measuring step comprises:\n (b1) heating the protein in the presence of each of a plurality of test compounds from 50\u00b0 C. to 80\u00b0 C., (b2) cooling the protein to 25\u00b0 C., (b3) maintaining the protein at 25\u00b0 C. for 10 seconds, and (b4) measuring the fluorescence of the protein.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 95.0
- Lexical Diversity: 1.69565
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13944477', '15423359', '15139192', '15221550', '13833008']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7609928090223248
- 35 USC 102 Novelty (BERT): 0.5518717997375617
- Combined Prediction Score: 0.7400807080938485
- Mean Citation Score: 250.22456
- Max Citation Score: 442.4466
- Similarity Product: 227.25096064896584

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test