PATENT CLAIM ANALYSIS

Application Number: 15973506
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "181100"]

Abstract:
Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.

Claim (Index 1):
A compound represented by the structure of Formula (IIIA): or a pharmaceutically acceptable salt thereof, wherein:\n  represents an optional double bond; \n L 11  is selected from \u2014C(O)\u2014 and \u2014C(O)N(R 10 )\u2014*, wherein * represents where L 11  is bound to R 6 ; \n L 2  is selected from a bond and \u2014C(O)\u2014; \n R 1  and R 2  are independently selected from hydrogen, C 1-10  alkyl, C 2-10  alkenyl and C 2-10  alkynyl; \n R 4  is selected from: \u2014OR 10 , \u2014N(R 10 ) 2 , \u2014C(O)N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , C 1-10  alkyl, C 2-10  alkenyl, and C 2-10  alkynyl; \n R 6  is selected from phenyl and 5- or 6-membered heteroaryl, any one of which is substituted with one or more substituents selected from R 7  and R 6  is further optionally substituted by one or more additional substituents independently selected from R 12 ; \n R 7  is selected from \u2014C(O)NHNH 2 , \u2014C(O)NH\u2014C 1-3  alkylene-NH(R 10 ), \u2014C(O)CH 3 , \u2014C 1-3  alkylene-NHC(O)OR 11 , \u2014C 1-3 alkylene-NHC(O)R 10 , \u2014C 1-3 alkylene-NHC(O)NHR 10 , \u2014C 1-3 alkylene-NHC(O)\u2014C 1-3 alkylene-R 10 , and a 3- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from R 12 ; \n R 10  is independently selected at each occurrence from hydrogen, \u2014NH 2 , and \u2014C(O)OCH 2 C 6 H 5 ; and C 1-10  alkyl, C 2-10  alkenyl, C 2-10  alkynyl, C 3-12  carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OH, \u2014CN, \u2014NO 2 , \u2014NH 2 , \u2550O, \u2550S, \u2014C(O)OCH 2 C 6 H 5 , \u2014NHC(O)OCH 2 C 6 H 5 , \u2014C 1-10  alkyl, \u2014C 1-10  haloalkyl, \u2014O\u2014C 1-10  alkyl, C 2-10  alkenyl, C 2-10  alkynyl, C 3-12  carbocycle, and 3- to 12-membered heterocycle; \n R 11  is selected from C 3-12  carbocycle and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R 12 ; and \n R 12  is independently selected at each occurrence from halogen, \u2014OR 10 , \u2014SR 10 , \u2014N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 )C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014P(O)(OR 10 ) 2 , \u2014OP(O)(OR 10 ) 2 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), and \u2014CN; C 1-10  alkyl, C 2-10  alkenyl, C 2-10  alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 )C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014P(O)(OR 10 ) 2 , \u2014OP(O)(OR 10 ) 2 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), \u2014CN, C 3-10  carbocycle and 3- to 10-membered heterocycle; and C 3-10  carbocycle and 3- to 10-membered heterocycle, wherein each C 3-10  carbocycle and 3- to 10-membered heterocycle in R 12  is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 )C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014P(O)(OR 10 ) 2 , \u2014OP(O)(OR 10 ) 2 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), \u2014CN, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 93.0
- Lexical Diversity: 1.5
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15774262', '15509989', '15829604', '13397195', '14112027']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7507922629825639
- 35 USC 102 Novelty (BERT): 0.6015906816880776
- Combined Prediction Score: 0.7358721048531153
- Mean Citation Score: 398.972402
- Max Citation Score: 534.74475
- Similarity Product: 447.3575482715964

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test