PATENT CLAIM ANALYSIS

Application Number: 15984281
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["540", "494000"]

Abstract:
This disclosure provides novel isoquinolidinobenzodiazepines. These compounds can also be incorporated into antibody-drug conjugates.

Claim (Index 66):
The antibody-drug conjugate of  claim 65 , having a structure of Formula III: wherein: is an antibody or antibody fragment;\n W\u2014R M  is a linking moiety formed by W and R x , wherein W is a moiety attached a natural or unnatural amino acid residue of the antibody/antibody fragment and R x  is a succinimidyl, maleimidyl, cylooctynyl, aminooxy, bisulfonyl, sulfonyl, or isothiocyanate moiety, such that W\u2014R M  is a disulfide, a thiolated succinimidyl, an amino substituted succinimidyl, a (cyclooctyl)-1, 4 triazolyl, oxime substituted N-glycan, oxime, a substituted bis-sulfopropyl, a sulfonamidyl, an amide, or a thiocarbamate moiety; \n L is a linker, wherein L is a bond or is a moiety having 1-200 nonhydrogen atoms selected from C, N, O, S, or halogen, and optionally incorporates ether, oxo, carboxamidyl, urethanyl, branched, cyclic, unsaturated, heterocyclic, aromatic or heteroaromatic moieties; \n j is a number of 1 to 10; and, \n IQB is a compound having a structure of Formula (I) or (II): \n wherein: the dotted bond shown between \u2014C(R a )\u2014 and \u2014N(R b )\u2014 or \u2014C(R a\u2032 )\u2014 and \u2014N(R b\u2032 )\u2014 is independently a single bond or a double bond; each of R a  and R a\u2032  is independently H, OH, or \u2014O\u2014P, where P is a protecting group; each of R b  and R b\u2032  is not present, or is independently H, or a bond linked to linker L; R 2 , R 2\u2032 , R 3 , R 3\u2032 , R 4 , R 4\u2032 , R 6\u2032  and R 6  are each independently selected from H, OH, C 1 -C 10  alkyl, C 2 -C 10  alkenyl or C 2 -C 10  alkynyl; each of R 5  or R 5\u2032  is independently NH 2 , CO 2 H, H, OH C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, or a bond linked to linker L; each of R 7  and R 7\u2032  is H; R 8  is: H, NH 2 , CO 2 H, or a bond linked to linker L, wherein the carbon to which R 8  is attached also has a hydrogen substituent; or an exo olefin having the structure wherein the carbon to which R 8  is attached has no other substituent;\n X is: \n C 1 -C 12  alkylene, optionally wherein the alkylene chain is interrupted by one or more hetero atoms selected from the group consisting of O, S, and NH; or \n \u2014(CH 2 ) m -Q-(CH 2 ) p \u2014, wherein m and p are each independently 0, 1 or 2; \n Q has a structure of formula: \n wherein each of R 9 , R 10  and R 11  is H, NH 2 , CO 2 H, or a bond linked to linker L; and J is CH or N; each of Y and Y\u2032 is independently O, S, or NH; each of Z and Z\u2032 is independently H, R, OH, OR, SH, SR, NH 2 , or NHR, where each R is independently unsubstituted C 1- C 12  alkyl, substituted C 1- C 12  alkyl, unsubstituted C 3- C20 heterocyclyl, substituted C 3- C 20  heterocyclyl, unsubstituted C 6- C 20  aryl groups, and unsubstituted C 6- C 20  aryl groups; and wherein only one of R b , R b\u2032 , R 5 , R 5\u2032 , R 8 , R 9 , R 10 , and R 11  is a bond linked to linker L.

Metadata:
- Claim Count in Document: 64.0
- Percentile: 93.0
- Lexical Diversity: 1.06667
- Patent Class: 540.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15335164', '15048865', '15904265', '13397195', '14849270']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7393461395982366
- 35 USC 102 Novelty (BERT): 0.6058158130961054
- Combined Prediction Score: 0.7259931069480235
- Mean Citation Score: 415.354686
- Max Citation Score: 569.9697
- Similarity Product: 439.84746604743

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test