PATENT CLAIM ANALYSIS

Application Number: 15927579
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "021800"]

Abstract:
The present invention relates to the preparation and use of therapeutic compounds for the treatment of diseases at specific subcellular target areas such as specific cellular organelles. In particular, the therapeutic compounds of the invention are specific for modifying enzyme activity within targeted organelles or structures of cells and tissues. Subcellular organelles and structures that may be specifically targeted by compounds of the present invention include lysosomes, autophagasomes, the endoplasmic reticulum, the Golgi complex, peroxisomes, the nucleus, membranes and the mitochondria.

Claim (Index 11):
A method of treating disease in a subject, comprising:\n A. preparing a targeted peptide conjugate having the general formula:\n T-LINK-DRUG \n where T represents a targeting group that is a peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, and SEQ ID NO:25; where DRUG is selected from the group consisting of: a cyclin-dependent kinase inhibitor, a glycogen synthase kinase 3 inhibitor, a glucosylceramidase activity inducer and a glucosylceramidase expression inducer; where LINK represents an optional linking group having 1-20 non-hydrogen atoms selected from the group consisting of C, N, O and S composed of any combination of chemical bonds, including ether, thioether, succinylthioether, benzylthioether, amine, ester, carboxamide, sulfonamide, hydrazide bonds, and single, double, triple carbon-carbon bonds, and aromatic or heteroaromatic bonds; and B. administering a therapeutically effective amount of said targeted peptide conjugate to a subject.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 90.0
- Lexical Diversity: 1.65455
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15477569', '14689267', '15837410', '14689576', '12381560']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7639472079103585
- 35 USC 102 Novelty (BERT): 0.6050387313031724
- Combined Prediction Score: 0.74805636024964
- Mean Citation Score: 400.858082
- Max Citation Score: 540.6215
- Similarity Product: 463.71293508324027

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test