PATENT CLAIM ANALYSIS

Application Number: 15756366
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "322000"]

Abstract:
The invention relates to antibacterial compounds of formula I wherein M is one of the groups M A , M B  and M C  represented below wherein R 1 , M A , M B  and M C  are as defined in the specification;and to salts thereof.

Claim (Index 1):
A compound of formula I wherein M is one of the groups M A , M B  and M C  represented below wherein R 1A  represents hydrogen or fluorine; R 3A  represents 3-fluoroazetidin-3-yl, 3-fluoro-1-methyl-azetidin-3-yl, 1-acetyl-3-hydroxyazetidin-3-yl, 3-fluoro-1-(oxetan-3-yl)azetidin-3-yl, (3-fluoroazetidin-1-yl)methyl, (3-hydroxyazetidin-1-yl)methyl, (5-(hydroxymethyl)-2-oxooxazolidin-3-yl)methyl, (4-hydroxy-3-fluoropiperidin-1-yl)methyl, (4-amino-3-fluoropiperidin-1-yl)methyl, (4-hydroxy-3,3-difluoropiperidin-1-yl)methyl, (4-amino-3,3-difluoropiperidin-1-yl)methyl, (6-amino-3-azabicyclo[3.1.0]hexan-3-yl)methyl, (2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl, 2-morpholino-1-hydroxyethyl, 2-(methylsulfonyl)ethoxy, (3-hydroxyazetidin-1-yl)carbonyloxymethyl, (4-hydroxypiperidin-1-yl)carbonyloxymethyl, (4-methylpiperazin-1-yl)carbonyloxymethyl, N-(2-hydroxyethyl)-N-(methyl)carbamoyloxymethyl, 1-hydroxy-2-[(2-methoxyethyl)(methyl)amino]ethyl, azetidin-3-yloxycarbonylaminomethyl or (N-methylazetidin-3-yl)oxycarbonylaminomethyl; R 1B  represents trans-2-(1,2-dihydroxyethyl)cycloprop-1-yl, 1-(methylamino)cycloprop-1-yl, 1-(dimethylamino)cycloprop-1-yl, 2-(dimethylaminomethyl)cycloprop-1-yl, 1-((3-hydroxyazetidinyl)-1-carbonyloxymethyl)cycloprop-1-yl, 2-(morpholinomethyl)cycloprop-1-yl, 1-((4-methylpiperazinyl)-1-carbonyloxymethyl)cycloprop-1-yl, 4-fluoropyrrolidin-2-yl, (2-oxooxazolidin-3-yl)methyl, 1-(3-hydroxyazetidine)-1-carbonyloxymethyl, (4-hydroxypiperidin-1-yl)carbonyloxymethyl, 1-(4-methylpiperazine)-1-carbonyloxymethyl or N-methylazetidin-3-yl)oxycarbonylaminomethyl, or R 1B  represents a group Q, Q being one of the groups Q A , Q B  and Q C  represented below wherein X A1  represents H, methyl-d, methyl-d2, (C 1 -C 4 )alkyl, acetyl, \u03c9-(C 2 -C 3 )haloalkyl, \u03c9-hydroxy(C 2 -C 3 )alkyl, 2,3-dihydroxyprop-1-yl, 3-hydroxy-2-(hydroxymethyl)prop-1-yl, oxetan-3-yl, thietan-3-yl, 1,1-dioxidothietan-3-yl, (C 3 -C 6 )cycloalkyl, 3-hydroxycyclobut-1-yl, tetrahydropyran-4-yl or (C 3 -C 6 )cycloalkyl(C 1 -C 3 )alkyl, X A21  and X A22  each independently represent H, (C 1 -C 4 )alkyl, (C 1 -C 3 )haloalkyl or hydroxy(C 1 -C 3 )alkyl, and X A3  represents H, (C 1 -C 3 )alkyl or halogen, provided that if X A1  represents oxetan-3-yl, at least one of X A21 , X A22  and X A3  does not represent H; X B1  represents H, (C 1 -C 4 )alkyl, \u03c9-hydroxy(C 2 -C 3 )alkyl, (C 3 -C 6 )cycloalkyl, oxetan-3-yl or tetrahydropyran-4-yl, X B21  and X B22  each independently represent H, (C 1 -C 4 )alkyl, (C 1 -C 3 )haloalkyl or hydroxy(C 1 -C 3 )alkyl, and X B4  represents H, halogen, hydroxy or (C 1 -C 3 )alkyl; X C1  represents H, (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, \u03c9-hydroxy(C 2 -C 3 )alkyl, oxetan-3-yl or tetrahydropyran-4-yl, X C2  represents H, (C 1 -C 4 )alkyl, (C 1 -C 3 )haloalkyl or hydroxy(C 1 -C 3 )alkyl, X C3  represents H, halogen, hydroxy, (C 1 -C 4 )alkyl, (C 1 -C 3 )haloalkyl, hydroxy(C 1 -C 3 )alkyl, and X C4  represents H, (C 1 -C 3 )alkyl, halogen or hydroxy; R 1C  represents hydrogen or fluorine; R 3C  represents a group Q as defined before; and R 1  represents H, PO 3 H 2 , SO 3 H, phosphonooxymethyl or the group L represented below wherein R 2  represents (C 1 -C 4 )alkylamino(C 1 -C 4 )alkyl, [di(C 1 -C 4 )alkylamino](C 1 -C 4 )alkyl, phosphonooxy(C 1 -C 4 )alkyl, phosphonooxymethoxy, 2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl, (2-(phosphonooxy)-phenyl)-(C 1 -C 4 )alkyl (especially 2-(2-(phosphonooxy)-phenyl)-ethyl) or [2-(phosphonooxy-(C 1 -C 4 )alkyl)-phenyl]-(C 1 -C 4 )alkyl; or a salt of this compound.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.51515
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15123184', '15021649', '15311758', '15106790', '15751596']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8308807731694237
- 35 USC 102 Novelty (BERT): 0.6450033627030735
- Combined Prediction Score: 0.8122930321227887
- Mean Citation Score: 564.289124
- Max Citation Score: 663.8811599999998
- Similarity Product: 552.9546032176136

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test