PATENT CLAIM ANALYSIS

Application Number: 15974494
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "447000"]

Abstract:
A novel α-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R 1  is the same or different, and represents a halogen atom, or a C 1 -C 3  alkyl group; R 2  represents a hydrogen atom, or a C 1 -C 6  alkyl group; p represents an integer of 0 to 5; V represents CR 3  wherein R 3  represents a hydrogen atom, an amino group, a nitro group, or a C 1 -C 3  alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.

Claim (Index 26):
The method of treating non-alcoholic steatohepatitis (NASH) according to  claim 23  wherein the compound is selected from a group consisting of:\n (R)-1-[4\u2032-(5-chloro-3-{[(1-phenylethoxy)carbonyl]amino}thiophen-2-yl)-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl]cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(2-fluorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(3-fluorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(4-fluorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(4-chlorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(o-tolyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(3,4-difluorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(2,5-difluorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(2,4-difluorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (RS)-1-{4\u2032-[5-chloro-3-({[1-(2-chloro-5-fluorophenyl)ethoxy]carbonyl}-amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-chloro-3-({[1-(2-chloro-4-fluorophenyl)ethoxy]carbonyl}amino)-thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (RS)-1-{4\u2032-[5-chloro-3-({[1-(5-fluoro-2-methylphenyl)ethoxy]carbonyl}-amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (RS)-1-{4\u2032-[5-chloro-3-({[1-(4-fluoro-2-methylphenyl)ethoxy]carbonyl}-amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-[4\u2032-(5-fluoro-3-({[(1-phenylethoxy)carbonyl]amino}thiophen-2-yl)-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl]cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-fluoro-3-({[1-(2-fluorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-fluoro-3-({[1-(3-fluorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-fluoro-3-({[1-(4-fluorophenyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[3-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-5-fluorothiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[3-({[1-(4-chlorophenyl)ethoxy]carbonyl}amino)-5-fluorothiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[5-fluoro-3-({[1-(o-tolyl)ethoxy]carbonyl}amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[3-({[1-(3,4-difluorophenyl)ethoxy]carbonyl}amino)-5-fluorothiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[3-({[1-(2,5-difluorophenyl)ethoxy]carbonyl}amino)-5-fluorothiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[3-({[1-(2,4-difluorophenyl)ethoxy]carbonyl}amino)-5-fluorothiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (RS)-1-{4\u2032-[3-({[1-(2-chloro-5-fluorophenyl)ethoxy]carbonyl}amino)-5-fluorothiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (R)-1-{4\u2032-[3-({[1-(2-chloro-4-fluorophenyl)ethoxy]carbonyl}amino)-5-fluorothiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n (RS)-1-{4\u2032-[5-fluoro-3-({[1-(5-fluoro-2-methylphenyl)ethoxy]carbonyl}-amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, and \n (RS)-1-{4\u2032-[5-fluoro-3-({[1-(4-fluoro-2-methylphenyl)ethoxy]carbonyl}-amino)thiophen-2-yl]-2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl}cyclopropanecarboxylic acid, \n or a pharmacologically acceptable salt thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 2.25373
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14752623', '11011773', '11577822', '13634678', '13260946']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8074465219401922
- 35 USC 102 Novelty (BERT): 0.6314051697437192
- Combined Prediction Score: 0.789842386720545
- Mean Citation Score: 401.994594
- Max Citation Score: 689.0333
- Similarity Product: 508.0515487104536

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test