PATENT CLAIM ANALYSIS

Application Number: 16239461
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["514", "653000"]

Abstract:
The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.

Claim (Index 1):
A sterile, ready-to-administer, packaged norepinephrine composition, comprising:\n a container filled with a sterile, ready-to-administer norepinephrine composition and packaged in a secondary container; wherein the sterile, ready-to-administer norepinephrine composition comprises norepinephrine or a salt thereof in an amount of between 10 \u03bcg/ml and 100 \u03bcg/ml, a chelating agent in an amount of between 1 \u03bcg/ml and 100 \u03bcg/ml, a tonicity adjusting agent in an amount of between 0.6 wt % and 1.2 wt %, and an aqueous acidic solution, wherein the norepinephrine comprises at least 95% of R-isomer of norepinephrine; wherein the sterile, ready-to-administer norepinephrine composition is substantially free of antioxidants; wherein the sterile, ready-to-administer norepinephrine composition has a pH of between 3.7 and 4.3; and wherein the sterile, ready-to-administer, packaged norepinephrine composition comprises at least about 90% R-isomer of norepinephrine after storage at 25\u00b12\u00b0 C. and 60\u00b15% relative humidity, over at least three months as determined by HPLC.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 99.0
- Lexical Diversity: 1.2973
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16239465', '16163476', '15883798', '16163480', '15949736']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8253224611645033
- 35 USC 102 Novelty (BERT): 0.5694693425955244
- Combined Prediction Score: 0.7997371493076054
- Mean Citation Score: 450.82184799999993
- Max Citation Score: 471.39062
- Similarity Product: 389.6074374334205

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test