PATENT CLAIM ANALYSIS

Application Number: 15890269
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["424", "450000"]

Abstract:
A method is presented for screening cells that produce allogeneic autophagosome enriched compositions able to induce expression of a selective marker on a subpopulation of peripheral blood mononuclear cells, the method comprising contacting a cell with a proteasome inhibitor, contacting the cell with a lysosome inhibitor, harvesting the resulting autophagosomes, determining a molecular signature of the harvested autophagosomes, and selecting cells that divert one or more Toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes. By screening for cells that divert one or more Toll-like receptor agonist and/or one or more molecular chaperones to the harvested autophagosomes, enriched populations of autophagosomes may be generated which may illicit a specific immune response against numerous cancer types. In this way, an allogeneic, off-the-shelf cancer vaccine may be produced and made available to be administered in order to stimulate a targeted immune response in patients bearing different tumor types.

Claim (Index 11):
A method for detecting an anti-cancer immune response in a mammal, comprising:\n isolating peripheral blood mononuclear cells from a mammal following an administration of one or more immunotherapeutic compositions to the mammal; contacting a subpopulation of the isolated peripheral blood mononuclear cells with an enriched population of autophagosomes derived from a cell line, the cell line selected via a method of screening cells such that the enriched population of autophagosomes includes: one or more toll-like receptor agonists; one or more tumor antigens; one or more damage-associated molecular pattern molecules; and determining a level of IFN-\u03b3 production by the contacted subpopulation of the isolated peripheral blood mononuclear cells.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 88.0
- Lexical Diversity: 1.87209
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14061135', '14512322', '11997294', '12271576', '14974357']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6901195890450131
- 35 USC 102 Novelty (BERT): 0.6829453860394643
- Combined Prediction Score: 0.6894021687444583
- Mean Citation Score: 389.1265560000001
- Max Citation Score: 767.65857
- Similarity Product: 647.300937898432

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test