PATENT CLAIM ANALYSIS

Application Number: 16000954
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "265100"]

Abstract:
Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula I: These compounds are useful in methods for treating cancer, selectively targeting cancerous cells via the proton coupled folate transporter, folate receptor alpha, and/or folate receptor beta pathways, inhibiting GARFTase in cancerous cells, and selectively targeting activated macrophages in a patient having an autoimmune disease, such as rheumatoid arthritis.

Claim (Index 19):
A pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula II or a pharmaceutically acceptable salt of a compound of Formula II: wherein R 1  is one of a hydrogen (H) or an alkyl group having from 1 to 6 carbon atoms; R 2  is one of (a) a hydrogen (H), (b) a CH 3 , (c) an OH, and (d) NHR wherein R is either a H or an alkyl group having from 1 to 6 carbon atoms; A is one of (a) CR\u2032R\u2033, (b) NR\u2032, wherein R\u2032 and R\u2033 are the same or different and are either a H or an alkyl group having from 1 to 6 carbon atoms, and (c) an oxygen (O); wherein the five membered ring has a side chain attached at position 6, and optionally includes wherein the carbon atom at position 5 has attached thereto either (a) one hydrogen atom, or (b) an alkyl group having from one to six carbon atoms, and R 3  is one of (a) a hydrogen (H), (b) CH 3 , (c) trifluoromethyl, (d) difluoromethyl, (e) monofluoromethyl, (f) methyl ketone, (g) trifluoromethyl ketone, (h) difluoromethyl ketone, (i) monofluoromethyl ketone, (j) formyl, (k) methyl alcohol, (l) methylamine, or (m) a bond; B is one of (a) a sulfur (S) atom, (b) an oxygen (O) atom, or (c) a nitrogen (N) atom; and y is an integer ranging from zero up to and including 7.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 94.0
- Lexical Diversity: 1.44828
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13558873', '15342359', '12242988', '12260502', '15769223']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7619367416531685
- 35 USC 102 Novelty (BERT): 0.5970114697192134
- Combined Prediction Score: 0.7454442144597729
- Mean Citation Score: 389.297826
- Max Citation Score: 496.8058
- Similarity Product: 471.7781197641252

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test