PATENT CLAIM ANALYSIS

Application Number: 15876454
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["536", "024500"]

Abstract:
Provided herein are compositions and methods for non-parenteral delivery of conjugated oligomeric compounds. In certain embodiments, compositions and methods are provided for oral delivery of conjugated oligomeric compounds. In certain embodiments, the oligomeric compounds are conjugated to one or more N-acetylgalactosamines or N-acetylgalactosamine analogues.

Claim (Index 1):
A composition comprising a single stranded antisense oligomeric compound for non-parenteral administration comprising:\n a 5\u2032-region consisting of 2-5 linked 5\u2032-region nucleosides; a 3\u2032-region consisting of 2-5 linked 3\u2032-region nucleosides; a central region located between the 5\u2032-region and the 3\u2032-region consisting of 10 linked central region deoxynucleosides; and a conjugate group comprising 3 moieties having the formula: wherein each 5\u2032 and 3\u2032-region nucleoside is a modified nucleoside and each central region nucleoside is a deoxynucleoside;\n each R 1  is selected from Q 1 , CH 2 Q 1 , CH 2 NJ 1 J 2 , CH 2 N 3  and CH 2 SJ 3 ; \n each Q 1  is selected from aryl, substituted aryl, heterocyclic, substituted heterocyclic, heteroaryl and substituted heteroaryl; \n each R 2  is selected from N 3 , CN, halogen, N(H)C(\u2550O)-Q 2 , substituted thiol, aryl, substituted aryl, heterocyclic, substituted heterocyclic, heteroaryl and substituted heteroaryl; \n each Q 2  is selected from H, C 1 -C 6  alkyl, substituted C 1 -C 6  alkyl, C 1 -C 6  alkoxy, substituted C 1 -C 6  alkoxy, aryl, substituted aryl, heterocyclic, substituted heterocyclic, heteroaryl and substituted heteroaryl; \n J 1 , J 2  and J 3  are each, independently, H or a substituent group; and \n each substituent group is, independently, mono or poly substituted with optionally protected substituent groups independently selected from halogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, aryl, heterocyclic and heteroaryl wherein each substituent group can include a linear or branched alkylene group optionally including one or more groups independently selected from O, S, NH and C(\u2550O), and wherein each substituent group may be further substituted with one or more groups independently selected from C 1 -C 6  alkyl, halogen or C 1 -C 6  alkoxy wherein each cyclic group is mono or polycyclic; and \n an excipient comprising sodium caprate (C10); \n wherein said oligomeric compound is at least 95% complementary to a target nucleic acid.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 86.0
- Lexical Diversity: 1.75
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14586751', '15311436', '14267842', '14839521', '14839580']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.681761095519869
- 35 USC 102 Novelty (BERT): 0.5649853287947254
- Combined Prediction Score: 0.6700835188473546
- Mean Citation Score: 449.5283539999999
- Max Citation Score: 508.3952
- Similarity Product: 363.9935192601204

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test