PATENT CLAIM ANALYSIS

Application Number: 16002472
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "04400R"]

Abstract:
The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.

Claim (Index 16):
A messenger RNA (mRNA) comprising:\n (i) a 5\u2032-terminal cap; (ii) a 5\u2032 untranslated region (UTR); (iii) an open reading frame (ORF) encoding the human methylmalonyl-CoA mutase (MCM) polypeptide of SEQ ID NO:213, wherein the ORF is at least 98% identical to the nucleotide sequence of SEQ ID NO:732; (iv) a 3\u2032 UTR; and (v) a poly-A tail.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 94.0
- Lexical Diversity: 1.33333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16002376', '15996146', '15995889', '15674569', '15674585']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8013610273179692
- 35 USC 102 Novelty (BERT): 0.6957055964545414
- Combined Prediction Score: 0.7907954842316264
- Mean Citation Score: 592.8691540000002
- Max Citation Score: 903.5448
- Similarity Product: 686.0240773756027

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test