PATENT CLAIM ANALYSIS

Application Number: 15765980
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "263100"]

Abstract:
The disclosure provides methods of using inhibitors of chaperone proteins, such as HSP90 inhibitors, in combination with agents that increase proteotoxic stress on tumor cells or agents that induce a biochemical rewiring of the chaperome. The proteotoxic agents are administered prior to administration of the chaperone proteins to achieve synergistic activity.

Claim (Index 42):
The method of any one of  claims 26 - 41 , wherein the cancer is selected from breast cancer, lung cancer including small cell lung cancer and non-small cell lung cancer, cervical cancer, colon cancer, choriocarcinoma, bladder cancer, cervical cancer, basal cell carcinoma, choriocarcinoma, colon cancer, colorectal cancer, endometrial cancer esophageal cancer, gastric cancer, head and neck cancer, acute lymphocytic cancer (ACL), myelogenous leukemia including acute myeloid leukemia (AML) and chronic myeloid chronic myeloid leukemia (CML), multiple myeloma, T-cell leukemia lymphoma, liver cancer, lymphomas including Hodgkin's disease, lymphocytic lymphomas, neuroblastomas follicular lymphoma and a diffuse large B-cell lymphoma, oral cancer, ovarian cancer, pancreatic cancer, prostate cancer, rectal cancer, sarcomas, skin cancers such as melanoma, testicular cancer, thyroid cancer, renal cancer, myeloproliferative disorders, gastrointestinal cancers including gastrointestinal stromal tumors, esophageal cancer, stomach cancer, a gallbladder cancer, anal cancer, brain tumors including gliomas, lymphomas including follicular lymphoma and diffuse large B-cell lymphoma.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 91.0
- Lexical Diversity: 1.375
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14131423', '14048540', '15103187', '15940055', '14005186']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7382398801016927
- 35 USC 102 Novelty (BERT): 0.5437869873490463
- Combined Prediction Score: 0.7187945908264282
- Mean Citation Score: 303.88358
- Max Citation Score: 395.372
- Similarity Product: 275.317260112524

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test