PATENT CLAIM ANALYSIS

Application Number: 16128982
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["424", "009100"]

Abstract:
A macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells.

Claim (Index 1):
A method of identification, visualization, quantification or isolation of proteins and/or cells in vitro or in an immunochemical method, comprising the steps of:\n providing a synthetic macromolecular conjugate adapted for selective interaction with proteins, characterized in that it contains a copolymer to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds, wherein said copolymer is a copolymer obtainable by copolymerization of at least one monomer of Formula 1: wherein: R 1  is selected from H, CH 3 ; R 2  is selected from NH 2 , NH\u2014CH 2 \u2014CH(OH)\u2014CH 3 , NH\u2014CH 3 , NH\u2014CH 2 CH 3 , NH\u2014CH 2 CH 2 \u2014OH, NH\u2014CH 2 CH 2 CH 2 \u2014OH, NHC(CH 2 OH) 3 , NH\u2014CH 2 CH 2 \u2014N + (CH 3 ) 3 Cl \u2212 , O\u2014CH 2 CH 2 \u2014OH, O\u2014(CH 2 CH 2 O) 2 \u2014H O\u2014(CH 2 CH 2 O) 3 \u2014H, O\u2014CH 2 CH 2 \u2014N + (CH 3 ) 3 Cl \u2212 , NH\u2014(CH 2 ) 3 N + (CH 3 ) 2 \u2014(CH 2 ) 2 \u2014COO \u2212 ; and at least one monomer of Formula 2: wherein: R 1  is selected from H, CH 3 , and X is selected from NH\u2014(CH 2 ) 2 \u2014CO, NH\u2014(CH 2 ) 3 \u2014CO, NH\u2014(CH 2 ) 4 \u2014CO, NH\u2014(CH 2 ) 5 \u2014CO, Gly, GlyGly, GlyPheLeuGly, and R 3  is selected from whereas at least one reactive group R 3  is replaced by the targeting ligand, at least one reactive group R 3  is replaced by the affinity tag, and at least one reactive group R 3  is replaced by the imaging probe; and binding to a target protein and/or cells a synthetic macromolecular conjugate, which contains a copolymer to which at least one affinity tag, wherein at least one imaging probe and at least one targeting ligand are bound via covalent bonds; and a step of identification, visualization, quantification or isolation of the target protein and/or cell using the affinity tag and/or the imaging probe of the macromolecular conjugate.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 97.0
- Lexical Diversity: 1.2381
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15542792', '14018985', '15239713', '15799927', '14821386']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.673573590959953
- 35 USC 102 Novelty (BERT): 0.593091260641572
- Combined Prediction Score: 0.6655253579281148
- Mean Citation Score: 288.630298
- Max Citation Score: 496.05722
- Similarity Product: 446.8452340987575

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test