PATENT CLAIM ANALYSIS

Application Number: 16073027
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["514", "265100"]

Abstract:
A pyrrolopyrimidine five-membered azacyclic derivative as a novel JAK kinase (Janus kinase) inhibitor, and use thereof in a preparation of a pharmaceutical product for preventing and/or treating an indication related to a JAK kinase function. The pyrrolopyrimidine five-membered azacyclic derivative is an ideal JAK kinase inhibitor with a high potency, and can be used to treat or prevent diseases such as rheumatoid arthritis, polycythemia vera, psoriasis, primary thrombocytosis, myelofibrosis, and the like.

Claim (Index 10):
A method for preparing the pyrrolopyrimidine five-membered azacyclic derivative according to  claim 1 , comprising the following steps:\n (a) reacting with a first amino protective reagent PG 1  to obtain wherein, Z is Cl, Br, or I,\n (b) reacting the product obtained in step (a) with \n to obtain wherein, R 5  is an alkoxy group or a silane group which are as amino protecting groups; when R 5  being an alkoxy group, first of all, placing the product obtained in step (a) and in a mixed solvent of alcohol and water, carrying out the reaction under a catalyst and a basic condition to make the group replace Z, and then removing R 5  under an acidic reaction condition;\n (c) using \n wherein PG 2  is a second amino protecting group, and subjecting the product obtained in step (b) to an addition reaction with followed by deprotection of the second amino protecting group PG 2  under an acidic condition to obtain wherein R 6  is CHCN or CH(CO)CN, m, n and R 1  are defined as before;\n (d) carrying out a substitution reaction in a polar solvent between the product obtained in step (c) and R 3 \u2014Cl to obtain \n then removing the first amino protecting group PG 1  to obtain i.e. a compound of formula (I).

Metadata:
- Claim Count in Document: 24.0
- Percentile: 95.0
- Lexical Diversity: 1.45614
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15536648', '10524204', '14000312', '15719867', '16311979']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7736417983661483
- 35 USC 102 Novelty (BERT): 0.4961668112570953
- Combined Prediction Score: 0.745894299655243
- Mean Citation Score: 236.689044
- Max Citation Score: 238.28767
- Similarity Product: 173.3413460577953

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test