PATENT CLAIM ANALYSIS

Application Number: 15926985
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["422", "500000"]

Abstract:
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

Claim (Index 16):
A method of forming a plurality of plugs and conducting a reaction in at least one thereof, the method comprising the steps of:\n providing a microfluidic device comprising a substrate having at least a first channel and a second channel intersecting each other at a junction; providing an aqueous fluid containing at least one biological molecule and one or more reagents for conducting a reaction with the at least one biological molecule; introducing to the first channel of the microfluidic device the aqueous fluid containing the at least one biological molecule and the one or more reagents for conducting the reaction with the at least one biological molecule; continuously flowing the aqueous fluid containing the at least one biological molecule and at the one or more reagents for conducting the reaction with the at least one biological molecule through the first channel; continuously flowing a carrier fluid immiscible with the aqueous fluid through the second channel of the; forming a plurality of plugs of the aqueous fluid containing the at least one biological molecule and the one or more reagents by partitioning the flowing aqueous fluid with the flowing immiscible carrier fluid at the junction of the first and second channels, each of the plurality of plugs being substantially surrounded by the immiscible carrier fluid, wherein at least one of the plurality of plugs comprises the at least one biological molecule and the one or more reagents for conducting the reaction with the at least one biological molecule; and providing conditions suitable for the reaction in the at least one plug involving the at least one biological molecule and the one or more reagents to form a reaction product.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 90.0
- Lexical Diversity: 1.27273
- Patent Class: 422.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13024171', '13024155', '13024145', '14517602', '13024165']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.851470915043586
- 35 USC 102 Novelty (BERT): 0.5620355841942313
- Combined Prediction Score: 0.8225273819586505
- Mean Citation Score: 451.509806
- Max Citation Score: 470.97363
- Similarity Product: 437.754934741627

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test