PATENT CLAIM ANALYSIS

Application Number: 16045901
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["546", "310000"]

Abstract:
Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.

Claim (Index 2):
The method of  claim 1 , wherein Ar is: wherein\n W 1  represents H or F; \n W 2  represents H, F, Cl, C 1-4  alkyl, C 1-3  haloalkyl, C 1-3  alkoxy, or C 1-3  haloalkoxy \n Y represents halogen, C 1-4  alkyl, C 1-4  haloalkyl, C 1-3  alkoxy, C 1-3  haloalkoxy, \u2014CN, or \u2014NO 2 ; and \n Z represents H, F, Cl, C 1-4  alkyl, C 1-3  alkoxy, C 1 -C 4  haloalkyl, C 1-3  haloalkoxy, C 1 -C 3  alkoxy-substituted C 1 -C 3  alkyl, or \u2014NR 1 R 2 , wherein R 1  and R 2  are independently hydrogen, C 1 -C 3  alkyl, or C 1 -C 3  haloalkyl; or \n Y and Z or Z and W 2  taken together are a 5-membered aromatic or non-aromatic, carbocyclic or heterocyclic ring.

Metadata:
- Claim Count in Document: 60.0
- Percentile: 95.0
- Lexical Diversity: 1.47826
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16045896', '15599716', '14049664', '13356691', '11906972']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7703013681321915
- 35 USC 102 Novelty (BERT): 0.5740117981761971
- Combined Prediction Score: 0.7506724111365921
- Mean Citation Score: 318.482256
- Max Citation Score: 443.61133
- Similarity Product: 431.9670328568155

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test