PATENT CLAIM ANALYSIS

Application Number: 16192424
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["544", "277000"]

Abstract:
The present disclosure is directed, in part, to compounds, or pharmaceutically acceptable salts thereof, for the treatment and/or prevention of neurodegenerative disease, mitochondrial disease, fibrosis, and/or cardiomyopathy.

Claim (Index 28):
A method of treating a neurodegenerative disease comprising administering to a subject in need thereof an effective amount of a compound comprising the following formula or pharmaceutically acceptable salt thereof: wherein X is independently selected from a C\u2014H, C\u2014CH 3 , C\u2014CH 2 CH 3 , C\u2014CH 2 CH 2 CH 3 , or CR 3 , wherein R 3  is independently selected from a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl; L 1  is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; R 1  is hydrogen, oxo, halogen, \u2014CY 3 , \u2014CN, \u2014SO 2 Cl, \u2014SO n R 10 , \u2014SO v NR 7 R 8 , \u2014NHNH 2 , \u2014ONR 7 R 8 , NHC\u2550(O)NHNH 2 , \u2014NHC\u2550(O)NR 7 R 8 , \u2014N(O) m , \u2014NR 7 R 8 , \u2014C(O)R 9 , \u2014C(O)OR 9 , \u2014C(O)NR 7 R 8 , \u2014OR 10 , NR 7 SO 2 R 10 , \u2014N(R 7 )C\u2550(O)R 9 , \u2014NR 7 C(O)\u2014OR 9 , \u2014NR 7 OR 9 , \u2014OCY 3 , \u2014OCHY 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 4  is hydrogen, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 2  is N; R 5  is CH, CCH3, CCF3, or CC6H5; and R 6  is N, a saturated carbon, CH, CD, or C\u2014L 1 \u2014R 6  wherein R 6  is independently halogen, \u2014CF 3 , \u2014CN, \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 2 Cl, \u2014SO 3 H, \u2014SO 4 H, \u2014SO 2 NH 2 , SO n R 10 , \u2014SO v NR 7 R 8 , \u2014NHNH 2 , \u2014ONH 2 , \u2014NHC\u2550(O)NHNH 2 , \u2014NHC\u2550(O)NH 2 , \u2014NHSO 2 H, \u2014NHC\u2550(O)H, \u2014NHC(O)\u2014OH, \u2014NHOH, \u2014ONR 7 R 8 , \u2014NHC\u2550(O)NHNH 2 , \u2014NHC\u2550(O)NR 7 R 8 , \u2014N(O) m , \u2014NR 7 R 8 , \u2014C(O)R 9 , \u2014C(O)OR 9 , \u2014C(O)NR 7 R 8 , \u2014OR 10 , \u2014NR 7 SO 2 R 10 , \u2014N(R 7 )C\u2550(O)R 9 , \u2014NR 7 C(O)\u2014OR 9 , \u2014NR 7 OR 9 , \u2014OCY 3 , \u2014OCHY 2 , \u2014OCF 3 , \u2014OCHF 2 , substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; where R 7  and R 8  are bonded to the same nitrogen atom, they may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl, m and v are independently 1 or 2, n is independently an integer from 0 to 4, and Y is independently \u2014Cl, \u2014Br, \u2014I, or \u2014F; wherein the compound does not comprise kinetin or cytokinin

Metadata:
- Claim Count in Document: 53.0
- Percentile: 98.0
- Lexical Diversity: 1.2963
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15118465', '16301200', '14815480', '14670088', '15536869']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7495841390882846
- 35 USC 102 Novelty (BERT): 0.55130407624444
- Combined Prediction Score: 0.7297561328039002
- Mean Citation Score: 336.361582
- Max Citation Score: 415.25836
- Similarity Product: 337.5976557357359

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test