PATENT CLAIM ANALYSIS

Application Number: 15916075
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "210180"]

Abstract:
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein R, R 1 , R 2a , R 2b , R 2c , A, B, L 1  and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Claim (Index 31):
The compound of  claim 30 , wherein the compound has the following structure (IE): wherein:\n G 1  is CH; \n G 2  is N or CH; \n R 3a  and R 3b  are, at each occurrence, independently H, \u2014OH, \u2014NH 2 , \u2014CO 2 H, halo, cyano, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 2 -C 6  alkynyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl; or R 3a  and R 3b  join to form oxo, a carbocyclic or heterocyclic ring; or R 3a  is H, \u2014OH, \u2014NH 2 , \u2014CO 2 H, halo, cyano, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 2 -C 6  alkynyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl, and R 3b  joins with R 4b  to form a carbocyclic or heterocyclic ring; \n R 4a  and R 4b  are, at each occurrence, independently H, \u2014OH, \u2014NH 2 , \u2014CO 2 H, halo, cyano, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 2 -C 6  alkynyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl; or R 4a  and R 4b  join to form oxo, a carbocyclic or heterocyclic ring; or R 4a  is H, \u2014OH, \u2014NH 2 , \u2014CO 2 H, halo, cyano, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  haloalkoxy, C 2 -C 6  alkynyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl, and R 4b  joins with R 3b  to form a carbocyclic or heterocyclic ring; and \n m 1  and m 2  are each independently 1, 2 or 3.

Metadata:
- Claim Count in Document: 92.0
- Percentile: 90.0
- Lexical Diversity: 1.62903
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15217304', '15093951', '15566648', '15353402', '15727422']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8574248165508513
- 35 USC 102 Novelty (BERT): 0.6470971343644204
- Combined Prediction Score: 0.8363920483322083
- Mean Citation Score: 659.8305280000002
- Max Citation Score: 683.0086
- Similarity Product: 560.7531002076506

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test