PATENT CLAIM ANALYSIS

Application Number: 16093565
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-03
Patent Classification: ["514", "259300"]

Abstract:
The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R 1 , R 2 , R 3  and R 4  are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Claim (Index 2):
The compound according to  claim 1 , wherein: o is 0, 1, 2, 3 or 4 R is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl and C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, n is 0 or 1, X, Y are independently selected from the group consisting of CR 5 R 6 , O, S, and N\u2014R 7 , wherein at least one of X and Y is CR 5 R 6 , R 1  is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -alkylcarbonyl, C 1 -C 4 -alkoxycarbonyl, C 3 -C 4 -alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, R 2  is selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkinyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, benzyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, \u2014NH 2 , \u2014NH(C 1 -C 4 -alkyl), \u2014N(C 1 -C 4 -alkyl) 2 , \u2014NH(C 3 -C 6 -cycloalkyl), \u2014N(C 1 -C 4 -alkyl)(C 3 -C 6 -cycloalkyl), \u2014NH(4- to 7-membered heterocycloalkyl), \u2014N(C 1 -C 4 -alkyl)(4- to 7-membered heterocycloalkyl), \u2014NH(C 1 -C 4 -alkoxy), \u2014N(C 1 -C 4 -alkyl)(C 1 -C 4 -alkoxy), \u2014NH\u2014SO 2 \u2014(C 1 -C 4 -alkyl), \u2014N(SO 2 \u2014[C 1 -C 4 -alkyl])(C 1 -C 4 -alkyl), (C 1 -C 4 -alkyl)-NH\u2014C 1 -C 4 -alkyl-, (C 1 -C 4 -alkyl) 2 -N\u2014C 1 -C 4 -alkyl-, \u2014S\u2014C 1 -C 4 -alkyl, \u2014S(O)\u2014C 1 -C 4 -alkyl, \u2014SO 2 \u2014C 1 -C 4 -alkyl, (C 1 -C 4 -alkoxyimino)-C 1 -C 4 -alkyl, and a monocyclic heterocycle selected from the group of 4- to 7-membered heterocycloalkyl, 5-membered heteroaryl having at least one nitrogen atom via which the heteroaryl ring is connected to the rest of the molecule, and 6-membered heteroaryl having at least one nitrogen atom, each of which in R 2  is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of hydrogen, halogen, cyano, nitro, \u2014OH, oxo, thiono, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, \u2014NH 2 , \u2014NH(C 1 -C 4 -alkyl), \u2014N(C 1 -C 4 -alkyl) 2 , \u2014S\u2014C 1 -C 4 -alkyl, \u2014S(O)\u2014C 1 -C 4 -alkyl, \u2014SO 2 \u2014C 1 -C 4 -alkyl, \u2014S\u2014C 1 -C 4 -halogenoalkyl, \u2014S(O)\u2014C 1 -C 4 -halogenoalkyl and \u2014SO 2 \u2014C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, and wherein each C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl and C 1 -C 4 -alkoxy in R 2  may be optionally substituted with halogen, OH, NH 2 , \u2014NH(C 1 -C 4 -alkyl), \u2014N(C 1 -C 4 -alkyl) 2 , cyano, carboxy, carbamoyl, alkoxycarbonyl, \u2014C(O)\u2014NH(C 1 -C 4 -alkyl), \u2014C(O)\u2014N(C 1 -C 4 -alkyl) 2 , C 1 -C 4 -alkoxy, \u2014S\u2014C 1 -C 4 -alkyl, \u2014S(O)\u2014C 1 -C 4 -alkyl, \u2014SO 2 \u2014C 1 -C 4 -alkyl, or optionally substituted by a monocyclic heterocycle selected from the group of azetidines, pyrrolidines, morpholines, piperidines, piperazines, pyrrolidinones, morpholinones, piperidinones, piperazinones, pyrazoles, triazoles, imidazoles and pyrroles, wherein a heteroaryl ring is connected to the C 1 -C 4 -alkyl or C 3 -C 6 -cycloalkyl via one of its nitrogen atoms, each of which as a substituent of C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl and C 1 -C 4 -alkoxy in R 2  is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of hydrogen, halogen, cyano, oxo, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, R 3  is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, R 4  is selected from the group consisting of hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, \u2014S\u2014C 1 -C 4 -alkyl, \u2014S(O)\u2014C 1 -C 4 -alkyl, \u2014SO 2 \u2014C 1 -C 4 -alkyl, R 5  is selected from the group consisting of hydrogen, fluorine or C 1 -C 4 -alkyl, R 6  is selected from the group consisting of hydrogen, fluorine or C 1 -C 4 -alkyl, R 7  is selected from the group consisting of hydrogen or C 1 -C 4 -alkyl, Q is selected from the group consisting of 6- or 10-membered aryl and 5- to 10-membered heteroaryl, each of which may be optionally substituted with 1, 2, 3, 4 or 5 substituents,\n or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of any of the foregoing.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 97.0
- Lexical Diversity: 1.67213
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15022583', '14914069', '15300057', '14767621', '14772471']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.795828447103549
- 35 USC 102 Novelty (BERT): 0.5157737785688379
- Combined Prediction Score: 0.7678229802500779
- Mean Citation Score: 295.60647
- Max Citation Score: 308.264
- Similarity Product: 262.2315921926498

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test