PATENT CLAIM ANALYSIS

Application Number: 15969328
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["546", "192000"]

Abstract:
Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

Claim (Index 20):
A method of detecting an amyloid or amyloid like protein comprising\n (i) contacting a compound of Formula Ic, or a salt or solvate thereof, with a sample potentially comprising the amyloid or amyloid like protein, wherein in presence of an amyloid or amyloid like protein the compound forms a detectable complex; and (ii) detecting the formation of the detectable complex such that the presence or absence of the detectable complex correlates with the presence or absence of the amyloid or amyloid like protein; wherein the compound of Formula Ic has the structure: wherein EDG is heterocycloalkyl of no more than 10 carbons optionally substituted with one or more R 17 ;\n wherein each R 17  is independently halogen, \u2014OR 18 , \u2014NR 19 R 20 , C 1 -C 10  alkyl, or C 1 -C 10  heteroalkyl; \n each of R 18 , R 19  and R 20  is independently hydrogen, C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl, or cycloalkyl of no more than 10 carbon atoms, each of which except for hydrogen is optionally substituted with one or more R 21 ; \n each R 21  is independently halogen, \u2014OR 22 , \u2014NR 23 R 24 , C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl, cycloalkyl of no more than 10 carbon atoms, heterocycloalkyl of no more than 10 carbon atoms, aryl of no more than 10 carbon atoms, or heteroaryl of no more than 10 carbon atoms; \n each of R 22 , R 23  and R 24  is independently hydrogen or C 1 -C 10  alkyl; \n Ar is aryl of no more than 14 carbon atoms optionally substituted with one or more R 1 ;\n each R 1  is independently halogen, \u2014OR 2 , \u2014NR 3 R 4 , C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl, \n each of R 2 , R 3  and R 4  is independently hydrogen, C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl; \n R 84  is hydrogen or C 1 -C 10  alkyl; EWG is halogen, \u2014CN, \u2014NO 2 , or methyl; WSG is: wherein n is an integer from 2 to 50, and R 81  is hydrogen, a C 1 -C 10  alkyl, a C 2 -C 10  alkenyl, or a C 2 -C 10  alkynyl, wherein the alkyl, alkenyl, or alkynyl is optionally substituted with one or more C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl, cycloalkyl of no more than 10 carbon atoms, heterocycloalkyl of no more than 10 carbon atoms, aryl of no more than 10 carbon atoms, or heteroaryl of no more than 10 carbon atoms; each R 82  is independently hydrogen or C 1 -C 10  alkyl; X is C\u2550O or SO 2 ; and Y is NH or S.

Metadata:
- Claim Count in Document: 48.0
- Percentile: 93.0
- Lexical Diversity: 1.4878
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14915883', '14572465', '14670088', '14507509', '16066285']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.746578813429544
- 35 USC 102 Novelty (BERT): 0.6202312656707792
- Combined Prediction Score: 0.7339440586536676
- Mean Citation Score: 368.946308
- Max Citation Score: 654.9379
- Similarity Product: 485.8450815162063

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test