PATENT CLAIM ANALYSIS

Application Number: 15767676
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "275000"]

Abstract:
Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Claim (Index 15):
A compound of Formula (II) wherein Z is selected from CR 2  and N; R 1  and R 2  are independently selected from hydrogen, halogen, hydroxyl, carboxyl, amino, nitro, cyano, isocyano, substituted or unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 1 -C 6  alkoxy, and substituted or unsubstituted C 1 -C 6  alkenyl; or wherein R 1  and R 2  together form a ring; R 3a  and R 3b  are independently selected from hydrogen and substituted or unsubstituted C 1 -C 6  alkyl; R 4  is selected from hydrogen, halogen, hydroxyl, carboxyl, amino, nitro, cyano, isocyano, substituted or unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 1 -C 6  alkoxy, substituted or unsubstituted C 1 -C 6  alkylamino, substituted or unsubstituted C 2 -C 6  alkenyl, and substituted or unsubstituted C 2 -C 6  alkynyl; or R 4  forms a ring with any of R 3a , R 3b  and R 3e , L 1  and L 3  are independently selected from (CR 3e 2 ) n , (CR 3e 2 ) n C(O), (CR 3e 2 ) n C(O)O, (CR 3e 2 ) n C(O)(NR 3c ), SO 2 , (CR 3e 2 ) n N(R 3c )P(O)(R 3c ), and (CR 3e 2 ) n P(O)N(R 3c ); R 3c  is in each case independently selected from hydrogen and substituted or unsubstituted C 1 -C 6  alkyl; R 3e  is in each case independently selected from hydrogen, halogen, hydroxyl, carboxyl, amino, nitro, cyano, isocyano, substituted or unsubstituted C 1 -C 6  alkyl, substituted or unsubstituted C 1 -C 6  alkoxy, substituted or unsubstituted C 1 -C 6  alkylamino substituted or unsubstituted C 2 -C 6  alkenyl, and substituted or unsubstituted C 2 -C 6  alkynyl; or two geminal R 3e  groups together form a carbonyl; or R 3e  groups on adjacent carbon atoms form a double or triple bond; or any two or more R 3e  groups together form a ring; or R 3e  forms a ring with any, some or all of R 3a , R 3b , R 3c  and R 4 ; n in each case is independently selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10; Q 1  and Q 3  are independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, and poly(ethylene oxide); or one or more substituents on Q 3  form a ring with R 3a , R 3c , R 3e  or R 4 ; or one or more substituents on Q 1  form a ring with R 3b , R 3c , R 3e  or R 4  groups; or a salt thereof.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 91.0
- Lexical Diversity: 1.43333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15501613', '15619671', '14204076', '14977508', '14633360']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7371609133673882
- 35 USC 102 Novelty (BERT): 0.5418177587831927
- Combined Prediction Score: 0.7176265979089687
- Mean Citation Score: 311.770436
- Max Citation Score: 366.1146
- Similarity Product: 292.63614721416235

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test