PATENT CLAIM ANALYSIS

Application Number: 15753188
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "001890"]

Abstract:
Subject matter of the present invention is PSMA Binding molecules for use in diagnosis and/or imaging of pain. Diagnosis or imaging of pain may be the visualization of the location of the origin of pain and/or the determination of the etiology of pain and/or the determination of the pain intensity and/or the stratification of subjects suffering from pain.

Claim (Index 5):
The PSMA-binding molecule comprising a detectable unit according to  claim 4  for use in the diagnosis and/or imaging of pain in a patient suffering from pain or in a patient that is suspected to suffer from pain, wherein said molecule is selected from the group comprising compounds of formulae (III) to (XI): wherein AA 1  and AA 2  each independently a natural or unnatural amino acid; R\u2032 is \u2014CO\u2014NR x R y \u2014, \u2014CS x R y \u2014, COR x , CSR x , C(NR x )R x , \u2014S(O) p R x \u2014, \u2014CO 2 \u2014NR x R y \u2014, or optionally substituted alkyl; R x  is optionally substituted aryl or optionally substituted alkyl; R y  is H, optionally substituted aryl or optionally substituted alkyl; X and Z are each independently C 1 -C 8  alkyl, C 2 -C 8  alkenyl, C 2 -C 8  alkynyl, C 1 -C 8  heteroalkyl, C 2 -C 8  heteroalkenyl, C 2 -C 8  heteroalkynyl, C 1 -C 8  alkoxy, or a bond, each of which may be substituted with 0-5 R A ; Y and W are each independently \u2014O\u2014, \u2014S(O) p \u2014, \u2014NH\u2014, \u2014NR B \u2014, \u2014CH\u2550CH\u2014, \u2014CR B \u2550CH\u2014, \u2014CH\u2550CR B \u2014, \u2014NH\u2014CO\u2014, \u2014NH\u2014CO 2 \u2014, \u2014NR B \u2014CO\u2014, \u2014NR B \u2014CO 2 \u2014; \u2014CO\u2014NH\u2014, \u2014CO 2 \u2014NH\u2014, \u2014CO\u2014NR B \u2014, \u2014CO 2 \u2014NR B \u2014, or a bond; p is 0, 1, or 2; R A , for each occurrence, is halogen, hydroxy, amino, cyano, nitro, CO 2 H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclo, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted alkylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted mono- or dialkylcarboxamide, optionally substituted aryl, or optionally substituted heteroaryl; and R B , for each occurrence, is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted aryl, or optionally substituted heteroaryl; wherein R 1  and R 2  are each independently selected from optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclo, \u2014COOH, hydroxyl, optionally substituted alkoxy, amino, optionally substituted mono or dialkylamino, thiol, and optionally substituted alkylthiol; AA 1  and AA 2  are each independently a natural or unnatural amino acid; X and Z are each independently C 1 -C 8  alkyl, C 2 -C 8  alkenyl, C 2 -C 8  alkynyl, C 1 -C 8  heteroalkyl, C 2 -C 8  heteroalkenyl, C 2 -C 8  heteroalkynyl, C 1 -C 8  alkoxy, or a bond, each of which may be substituted with 0-5 R A ; Y is \u2014O\u2014, \u2014S(O) p \u2014, \u2014NH\u2014, \u2014NR B \u2014, \u2014CH\u2550CH\u2014, \u2014CR B \u2550CH\u2014, \u2014CH\u2550CR B \u2014, \u2014NH\u2014CO\u2014, \u2014NH\u2014CO 2 \u2014, \u2014NR B \u2014CO\u2014, \u2014NR B \u2014CO 2 \u2014; \u2014CO\u2014NH\u2014, \u2014CO 2 \u2014NH\u2014, \u2014CO\u2014NR B \u2014, \u2014CO 2 \u2014NR B \u2014, or a bond; p is 0, 1, or 2; R A , for each occurrence, is halogen, hydroxy, amino, cyano, nitro, CO 2 H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclo, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted alkylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted mono- or dialkylcarboxamide, optionally substituted aryl, or optionally substituted heteroaryl; and R B , for each occurrence, is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted aryl, or optionally substituted heteroaryl; wherein AA 1  and AA 2  are each independently a natural amino acid; R 1  is pyridyl, pyrimidinyl, pyrazinyl, pyridizinyl, quinolinyl, thienyl, thiazolyl, oxazolyl, isoxazolyl, pyrrolyl, furanyl, isoquinolinyl, imiazolyl, or triazolyl; R 2  is pyridyl, pyrimidinyl, pyrazinyl, pyridizinyl, quinolinyl, thienyl, thiazolyl, oxazolyl, isoxazolyl, pyrrolyl, furanyl, isoquinolinyl, or triazolyl, \u2014COOH, hydroxyl, alkoxy, amino, mono or dialkylamino; R A , for each occurrence, is halogen, hydroxy, amino, cyano, nitro, or CO 2 H; m is 0 or 1; each n is independently 1-8; and each q is independently 0 or 1; wherein each R D  is independently H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclo, or optionally substituted aralkyl; each R E  is independently H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclo, or optionally substituted aralkyl; R 1  is pyridyl, pyrimidinyl, pyrazinyl, pyridizinyl, isoquinolinyl, imiazolyl, or quinolinyl; R 2  is pyridyl, pyrimidinyl, pyrazinyl, pyridizinyl, isoquinolinyl, quinolinyl; \u2014COOH, hydroxyl, alkoxy, amino, mono or dialkylamino; R A , for each occurrence, is hydroxy, amino, or CO 2 H; each m is independently 0 or 1; and each n is independently 1-8; wherein AA 1  and AA 2  are each independently a natural amino acid; R\u2032 is \u2014CO\u2014NR x R y \u2014, \u2014CS\u2014NR x R y \u2014, COR x , CSR x , C(NR x )R x , \u2014S(O) p R x \u2014, \u2014CO 2 \u2014NR x R y \u2014, or optionally substituted alkyl; R\u2033 is H or optionally substituted alkyl; R\u2033 is optionally substituted aryl or optionally substituted alkyl; R y  is H, optionally substituted aryl or optionally substituted alkyl; R A , for each occurrence, is halogen, hydroxy, amino, cyano, nitro, or CO 2 H; each n is independently 0-8; and each q is independently 0 or 1; wherein R\u2033 is H or optionally substituted alkyl; R x  is optionally substituted aryl or optionally substituted alkyl; R y  is H, optionally substituted aryl or optionally substituted alkyl; AA 1  and AA 2  are each independently a natural or unnatural amino acid; X and Z are each independently C 1 -C 8  alkyl, C 2 -C 8  alkenyl, or C 2 -C 8  alkynyl, C 1 -C 8  heteroalkyl, C 2 -C 8  heteroalkenyl, or C 2 -C 8  heteroalkynyl, C 1 -C 8 alkoxy, or a bond, each of which may be substituted with 0-5 R A ; Y is \u2014O\u2014, \u2014S(O) p \u2014, \u2014NH\u2014, \u2014NR B \u2014, \u2014CH\u2550CH\u2014, \u2014CR B \u2550CH\u2014, \u2014CH\u2550CR B \u2014, \u2014NH\u2014CO\u2014, \u2014NH\u2014CO 2 \u2014, \u2014NR B \u2014CO\u2014, \u2014NR B \u2014CO 2 \u2014; \u2014CO\u2014NH\u2014, \u2014CO 2 \u2014NH\u2014, \u2014CO\u2014NR B \u2014, \u2014CO 2 \u2014NR B \u2014, or a bond; p is 0, 1, or 2; R A , for each occurrence, is halogen, hydroxy, amino, cyano, nitro, CO 2 H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclo, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted alkylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted mono- or dialkylcarboxamide, optionally substituted aryl, or optionally substituted heteroaryl; and R B , for each occurrence, is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted aryl, or optionally substituted heteroaryl; wherein R\u2033 is H or optionally substituted alkyl; R x  is optionally substituted aryl or optionally substituted alkyl; AA 1  and AA 2  are each independently a natural or unnatural amino acid; X and Z are each independently C 1 -C 8  alkyl, C 2 -C 8  alkenyl, or C 2 -C 8  alkynyl, C 1 -C 8  heteroalkyl, C 2 -C 8  heteroalkenyl, or C 2 -C 8  heteroalkynyl, C 1 -C 8 alkoxy, or a bond, each of which may be substituted with 0-5 R A ; Y is \u2014O\u2014, \u2014S(O) p \u2014, \u2014NH\u2014, \u2014NR B \u2014, \u2014CH\u2550CH\u2014, \u2014CR B \u2550CH\u2014, \u2014CH\u2550CR B \u2014, \u2014NH\u2014CO\u2014, \u2014NH\u2014CO 2 \u2014, \u2014NR B \u2014CO\u2014, \u2014NR B \u2014CO 2 \u2014; \u2014CO\u2014NH\u2014, \u2014CO 2 \u2014NH\u2014, \u2014CO\u2014NR B \u2014, \u2014CO 2 \u2014NR B \u2014, or a bond; p is 0, 1, or 2; R A , for each occurrence, is halogen, hydroxy, amino, cyano, nitro, CO 2 H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclo, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted alkylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted mono- or dialkylcarboxamide, optionally substituted aryl, or optionally substituted heteroaryl; and R B , for each occurrence, is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted aryl, or optionally substituted heteroaryl; wherein M is a metal or Al\u2014F; R L  is a metal ligand; R\u2032 is \u2014CO\u2014NR x R y \u2014, \u2014CS\u2014NR x R y \u2014, COR x , CSR x , C(NR x )R x , \u2014S(O) p R x \u2014, \u2014CO 2 \u2014NR x R y \u2014, or optionally substituted alkyl; R\u2033 is H or optionally substituted alkyl; R x  is optionally substituted aryl or optionally substituted alkyl; R y  is H, optionally substituted aryl or optionally substituted alkyl; X and Z are each independently C 1 -C 8 alkyl, C 2 -C 8  alkenyl, C 2 -C 8  alkynyl, C 1 -C 8  heteroalkyl, C 2 -C 8  heteroalkenyl, C 2 -C 8  heteroalkynyl, C 1 -C 8  alkoxy, or a bond, each of which may be substituted with 0-5 R A ; Y and W are each independently \u2014O\u2014, \u2014S(O) p \u2014, \u2014NH\u2014, \u2014NR B \u2014, \u2014CH\u2550CH\u2014, \u2014CR B \u2550CH\u2014, \u2014CH\u2550CR B \u2014, \u2014NH\u2014CO\u2014, \u2014NH\u2014CO 2 \u2014, \u2014NR B \u2014CO\u2014, \u2014NR B \u2014CO 2 \u2014; \u2014CO\u2014NH\u2014, \u2014CO 2 \u2014NH\u2014, \u2014CO\u2014NR B \u2014, \u2014CO 2 \u2014NR B \u2014, or a bond; p is 0, 1, or 2; R A , for each occurrence, is halogen, hydroxy, amino, cyano, nitro, CO 2 H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclo, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted alkylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted mono- or dialkylcarboxamide, optionally substituted aryl, or optionally substituted heteroaryl; and R B , for each occurrence, is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted mono or dialkylamino, optionally substituted alkylthio, optionally substituted aryl, or optionally substituted heteroaryl and r is 1-5; and wherein the definitions of the residues are the same as in Formula X.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 88.0
- Lexical Diversity: 1.875
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15639445', '14715115', '15764316', '14211683', '15385490']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7217192721166132
- 35 USC 102 Novelty (BERT): 0.5240293884397959
- Combined Prediction Score: 0.7019502837489315
- Mean Citation Score: 279.99895000000004
- Max Citation Score: 326.13727
- Similarity Product: 206.0390630122584

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test