PATENT CLAIM ANALYSIS

Application Number: 15880513
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["800", "018000"]

Abstract:
The present invention provides a transgenic mouse which comprises a deficiency for murine T lymphocytes, B lymphocytes and NK cells, a deficiency for murine MHC class I and MHC class II molecules, and a functional xenogenic SIRPα transgene. This mouse is useful for in vivo screening of various compounds, including immuno-therapeutic agents and vaccines. The said mouse is also useful for testing the in vivo metabolism of xenobiotic compounds.

Claim (Index 13):
A method of producing a multichimeric mouse, the said method comprising the step of transplanting, by any appropriate means, precursor cells of a xenogenic species into the transgenic mouse of any one of  claims 1  to  12 , wherein: the precursor cells comprise hematopoietic and non-hematopoietic precursors, and the functional MHC class I transgene and the functional MHC class II transgene and the functional xenogenic SIRP\u03b1 transgene are from the same species as the precursor cells.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 86.0
- Lexical Diversity: 1.58333
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14388108', '15223879', '13847636', '12918676', '13551137']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6225687146096949
- 35 USC 102 Novelty (BERT): 0.6125020843492381
- Combined Prediction Score: 0.6215620515836492
- Mean Citation Score: 386.186864
- Max Citation Score: 670.8642
- Similarity Product: 499.37661178150177

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test