PATENT CLAIM ANALYSIS

Application Number: 16091567
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["546", "314000"]

Abstract:
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Claim (Index 42):
The compound according to  claim 31  which is:\n tert-Butyl 4-(3-(2-benzyl-6-(methylcarbamoyl)isonicotinamido)propyl)piperidine-1-carboxylate; \n 6-Benzyl-N 2 -methyl-N 4 -(2-(piperidin-4-yl)ethyl)pyridine-2,4-dicarboxamide; \n 6-Benzyl-N 2 -methyl-N 4 -(3-(piperidin-4-yl)propyl)pyridine-2,4-dicarboxamide; \n 6-Benzyl-N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-Benzyl-N 2 -methyl-N 4 -(oxetan-3-yl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-6-(3-Methoxybenzyl)-N 2 -methyl-N 4 -(2-(morpholin-2-yl)ethyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-6-(3-Methoxybenzyl)-N 2 -methyl-N 4 -(2-(4-methylmorpholin-2-yl)ethyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-tert-Butyl 2-(2-(2-(methylcarbamoyl)-6-(1-phenylethyl)isonicotinamido)ethyl)morpholine-4-carboxylate; \n 6-Benzyl-N 2 -methyl-N 4 -(3-morpholinopropyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-6-Benzyl-N 2 -methyl-N 4 -(tetrahydrofuran-3-yl)pyridine-2,4-dicarboxamide; \n 6-Benzyl-N 2 -methyl-N 4 -(3-(piperazin-1-yl)propyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-6-Benzyl-N 2 -methyl-N 4 -(2-(4-methylmorpholin-2-yl)ethyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-N 2 -Methyl-N 4 -(2-(morpholin-2-yl)ethyl)-6-(1-phenylethyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(3-methoxybenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-tert-Butyl 4-(2-(2-(methylcarbamoyl)-6-(1-phenylethyl)isonicotinamido)ethyl)piperidine-1-carboxylate; \n (+/\u2212)-N 2 -Methyl-6-(1-phenylethyl)-N4-(2-(piperidin-4-yl)ethyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6s)-3-Azabicyclo[3.1.0]hexan-6-yl)-6-(3-methoxybenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (1R,5S,6s)-tert-Butyl 6-(2-(3-methoxybenzyl)-6-(methylcarbamoyl)isonicotinamido)-3-azabicyclo[3.1.0]hexane-3-carboxylate; \n 6-(3-Methoxybenzyl)-N 2 -methyl-N 4 -((1R,5S,6s)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6s)-3-Acetyl-3-azabicyclo[3.1.0]hexan-6-yl)-6-(3-methoxybenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-Benzyl-N 2 -methyl-N 4 -(tetrahydro-2H-pyran-4-yl)pyridine-2,4-dicarboxamide; \n 6-Benzyl-N 4 -((1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6-yl)-N 2 -methylpyridine-2,4-dicarboxamide hydrochloride; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(3-(2-hydroxyethoxy)benzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-6-Benzyl-N 2 -methyl-N 4 -(2-(piperidin-3-yl)ethyl)pyridine-2,4-dicarboxamide hydrochloride; \n 6-Benzyl-N 2 -methyl-N 4 -(2-(tetrahydro-2H-pyran-4-yl)ethyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-6-(3-Methoxybenzyl)-N 2 -methyl-N 4 -(3-(morpholin-2-yl)propyl)pyridine-2,4-dicarboxamide; \n N 2 -Methyl-N 4 -(3-((S)-morpholin-2-yl)propyl)-6-(1-phenylethyl)pyridine-2,4-dicarboxamide; \n (R)-6-(3-Methoxybenzyl)-N 2 -methyl-N 4 -(3-(morpholin-2-yl)propyl)pyridine-2,4-dicarboxamide; \n (S)-6-(3-Methoxybenzyl)-N 2 -methyl-N 4 -(3-(morpholin-2-yl)propyl)pyridine-2,4-dicarboxamide; \n N 2 -Methyl-N 4 -(2-((S)-morpholin-2-yl)ethyl)-6-(1-phenylethyl)pyridine-2,4-dicarboxamide; \n N 2 -Methyl-N 4 -(2-((R)-morpholin-2-yl)ethyl)-6-(1-phenylethyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-(1-phenylethyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-6-Benzyl-N 4 -(3-(3-fluoropiperidin-3-yl)propyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-tert-Butyl 3-(3-(2-benzyl-6-(methylcarbamoyl)isonicotinamido)propyl)-3-fluoropiperidine-1-carboxylate; \n (S)-6-((1H-Indol-4-yl)methyl)-N 2 -methyl-N 4 -(3-(morpholin-2-yl)propyl)pyridine-2,4-dicarboxamide; \n (R)-6-Benzyl-N 2 -methyl-N 4 -(2-(morpholin-2-yl)ethyl)pyridine-2,4-dicarboxamide; \n (S)-6-Benzyl-N 2 -methyl-N 4 -(3-(morpholin-2-yl)propyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-((S*)-1-phenylethyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-((R*)-1-phenylethyl)pyridine-2,4-dicarboxamide; \n N 2 -Methyl-N 4 -(2-((S)-morpholin-2-yl)ethyl)-6-((R*)-1-phenylethyl)pyridine-2,4-dicarboxamide; \n N 2 -Methyl-N 4 -(2-((S)-morpholin-2-yl)ethyl)-6-((S*)-1-phenylethyl)pyridine-2,4-dicarboxamide; \n N 2 -Methyl-N 4 -(2-((S)-morpholin-2-yl)ethyl)-6-((S*)-1-phenylethyl)pyridine-2,4-dicarboxamide hydrochloride; \n (S)-6-Benzyl-N 2 -methyl-N 4 -(2-(morpholin-2-yl)ethyl)pyridine-2,4-dicarboxamide; \n (S)-6-Benzyl-N 4 -(3-(4-isopropylmorpholin-2-yl)propyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-Benzyl-N 4 -4R*)-2-hydroxy-2-((S)-morpholin-2-yl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-Benzyl-N 4 -((S*)-2-hydroxy-2-((S)-morpholin-2-yl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (S)-6-((1H-Indol-4-yl)methyl)-N 4 -(3-(4-isopropylmorpholin-2-yl)propyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (R)-6-Benzyl-N 4 -(3-(3-fluoropiperidin-3-yl)propyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (S)-6-Benzyl-N 4 -(3-(3-fluoro-1-isopropylpiperidin-3-yl)propyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (R)-6-Benzyl-N 4 -(2-(4-isopropylmorpholin-2-yl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (\u00b1)-6-Benzyl-N 4 -(3-(4,4-difluoropiperidin-3-yl)propyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-((1H-Indol-4-yl)methyl)-N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (S)-6-((1H-Indol-4-yl)methyl)-N 4 -(3-(3-fluoropiperidin-3-yl)propyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 2 -Methyl-N 4 -(2-((R)-morpholin-2-yl)ethyl)-6-((S*)-1-phenylethyl)pyridine-2,4-dicarboxamide; \n N 2 -Methyl-N 4 -(2-((R)-morpholin-2-yl)ethyl)-6-((R*)-1-phenylethyl)pyridine-2,4-dicarboxamide; \n 6-((1H-Indol-4-yl)methyl)-N 4 -((1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6-yl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (R)-6-Benzyl-N 4 -(2-(3-fluoropiperidin-3-yl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N2-Methyl-N 4 -(3-((S)-morpholin-2-yl)propyl)-6-((R*)-1-phenylethyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6s)-3-Acetyl-3-azabicyclo[3.1.0]hexan-6-yl)-6-benzyl-N 2 -methylpyridine-2,4-dicarboxamide; \n (R)-6-Benzyl-N 4 -(2-(4-(2,2-difluoroethyl)morpholin-2-yl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-Benzyl-N 2 -methyl-N 4 -(3-(4-methyl-3-oxopiperazin-1-yl)propyl)pyridine-2,4-dicarboxamide; \n 6-Benzyl-N 2 -methyl-N 4 -(3-(3-oxopiperazin-1-yl)propyl)pyridine-2,4-dicarboxamide; \n (\u00b1)-tert-Butyl 4-(2-(2-benzyl-6-(methylcarbamoyl)isonicotinamido)ethyl)-3,3-difluoropiperidine-1-carboxylate; \n N 4 -(3-((R)-3-Fluoropiperidin-3-yl)propyl)-N 2 -methyl-6-(1-phenylethyl)pyridine-2,4-dicarboxamide; \n 6-Benzyl-N 2 -methyl-N 4 -(3-(2-oxopiperazin-1-yl)propyl)pyridine-2,4-dicarboxamide, hydrochloride; \n 6-Benzyl-N 4 -((1R,5S,6s)-3-(2,2-difluoroethyl)-3-azabicyclo[3.1.0]hexan-6-yl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (\u00b1)-6-Benzyl-N 4 -(2-(4,4-difluoropiperidin-3-yl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide, hydrochloride; \n (\u00b1)-6-Benzyl-N 4 -(2-(3,3-difluoropiperidin-4-yl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide, hydrochloride; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(4-cyanobenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N2-methyl-6-(4-methylbenzyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((S)-hydroxy(phenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((R)-hydroxy(phenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-(3-methylbenzyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(3-cyanobenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (R)\u2014N 2 -Methyl-6-(3-methylbenzyl)-N 4 -(2-(morpholin-2-yl)ethyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(2-methoxybenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(hydroxy(phenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-tert-Butyl 2-(3-(2-(3-methoxybenzyl)-6-(methylcarbamoyl)isonicotinamido)propyl)morpholine-4-carboxylate; \n (\u00b1)-tert-Butyl 3-(2-(2-benzyl-6-(methylcarbamoyl)isonicotinamido)ethyl)-4,4-difluoropiperidine-1-carboxylate; \n 6-(3-Methoxybenzyl)-N 2 -methyl-N 4 -(tetrahydro-2H-pyran-4-yl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -(2-(4-Acetylmorpholin-2-yl)ethyl)-6-(3-methoxybenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-6-Benzyl-N 2 -methyl-N 4 -(tetrahydro-2H-pyran-3-yl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-6-Benzyl-N 2 -methyl-N 4 -((tetrahydrofuran-3-yl)methyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -(2-(4-Acetylmorpholin-2-yl)ethyl)-6-benzyl-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-6-Benzyl-N 2 -methyl-N 4 -((tetrahydrofuran-2-yl)methyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-6-Benzyl-N 2 -methyl-N 4 -((tetrahydro-2H-pyran-2-yl)methyl)pyridine-2,4-dicarboxamide; \n N 4 -(Azetidin-3-yl)-6-benzyl-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-Benzyl-N 2 -methyl-N 4 -((tetrahydro-2H-pyran-4-yl)methyl)pyridine-2,4-dicarboxamide; \n N 2 -Methyl-N 4 -(3-((S)-morpholin-2-yl)propyl)-6-((S*)-1-phenylethyl)pyridine-2,4-dicarboxamide; \n 6-41H-Pyrrolo[2,3-c]pyridin-4-yl)methyl)-N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6s)-3-Azabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-(3-methylbenzyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6s)-3-Azabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-(3-methylbenzyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(1-(3-methoxyphenyl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((2-cyano-1H-indol-4-yl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((3-cyano-1H-indol-4-yl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-(1-phenylpropyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-((R*)-1-phenylpropyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-((S*)-1-phenylpropyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-41-(2-hydroxyethyl)-1H-indol-4-yl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-43-(2,2,2-trifluoroacetyl)-1H-indol-4-yl)methyl)pyridine-2,4-dicarboxamide; \n (\u00b1)-6-Benzyl-N 4 -(3-(3,3-difluoropiperidin-4-yl)propyl)-N 2 -methylpyridine-2,4-dicarboxamide hydrochloride; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(methoxy(phenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4S*)-1-(3-methoxyphenyl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4R*)-1-(3-methoxyphenyl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4S*)-methoxy(phenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-6-4R*)-methoxy(phenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-6-(1-(1H-Indol-4-yl)ethyl)-N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N2-methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-6-Benzyl-N 2 -methyl-N 4 -(3-(2-methylmorpholin-2-yl)propyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(chloro(pyridin-2-yl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -(2-((2r,5r)-5-Amino-1,3-dioxan-2-yl)ethyl)-6-benzyl-N2-methylpyridine-2,4-dicarboxamide; \n 6-((S*)-1-(1H-Indol-4-yl)ethyl)-N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-((R*)-1-(1H-Indol-4-yl)ethyl)-N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(1-(2-methoxyphenyl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -(3-((2r,5r)-5-Amino-1,3-dioxan-2-yl)propyl)-6-benzyl-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(2-methoxy-1-phenylethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N2-methyl-6-(1-(2-oxoindolin-4-yl)ethyl)pyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(hydroxy(2-methoxyphenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n tert-Butyl 3,3-difluoro-4-(3-(2-(methylcarbamoyl)-6-((S)-1-phenylethyl)isonicotinamido)propyl)piperidine-1-carboxylate; \n tert-Butyl 3,3-difluoro-4-(2-(2-(methylcarbamoyl)-6-((S)-1-phenylethyl)isonicotinamido)ethyl)piperidine-1-carboxylate; \n tert-Butyl 4,4-difluoro-3-(2-(2-(methylcarbamoyl)-6-((S)-1-phenylethyl)isonicotinamido)ethyl)piperidine-1-carboxylate; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((S*)-2-methoxy-1-phenylethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((R*)-2-methoxy-1-phenylethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4S*)-hydroxy(2-methoxyphenyl)methyl)-N2-methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4R*)-hydroxy(2-methoxyphenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -(2-4S*)-3,3-Difluoropiperidin-4-yl)ethyl)-N 2 -methyl-6-((S)-1-phenylethyl)pyridine-2,4-dicarboxamide, hydrochloride; \n N 4 -(2-4R*)-3,3-Difluoropiperidin-4-yl)ethyl)-N 2 -methyl-6-((S)-1-phenylethyl)pyridine-2,4-dicarboxamide, hydrochloride; \n (\u00b1)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(1-(1-formylindolin-4-yl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4S*)-1-(2-methoxyphenyl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4R*)-1-(2-methoxyphenyl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (\u00b1)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(1-(indolin-4-yl)ethyl)-N2-methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(hydroxy(m-tolyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(indolin-4-ylmethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-N4-((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(hydroxy(o-tolyl)methyl)-N2-methylpyridine-2,4-dicarboxamide; \n N 4 -(3-((2r,5S)-5-Amino-1,3-dioxan-2-yl)propyl)-N 2 -methyl-6-((S)-1-phenylethyl)pyridine-2,4-dicarboxamide; \n N 4 -(3-4S*)-3,3-Difluoropiperidin-4-yl)propyl)-N 2 -methyl-6-((S)-1-phenylethyl)pyridine-2,4-dicarboxamide hydrochloride; \n N 4 -(3-4R*)-3,3-Difluoropiperidin-4-yl)propyl)-N 2 -methyl-6-((S)-1-phenylethyl)pyridine-2,4-dicarboxamide hydrochloride; \n N 4 -(2-((S*)-4,4-Difluoropiperidin-3-yl)ethyl)-N 2 -methyl-6-((S)-1-phenylethyl)pyridine-2,4-dicarboxamide hydrochloride; \n N 4 -(2-4R*)-4,4-Difluoropiperidin-3-yl)ethyl)-N 2 -methyl-6-((S)-1-phenylethyl)pyridine-2,4-dicarboxamide hydrochloride; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(hydroxy(p-tolyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((2-chlorophenyl)(hydroxy)methyl)-N2-methylpyridine-2,4-dicarboxamide; \n (R*)-6-Benzyl-N 2 -methyl-N 4 -(3-(2-methylmorpholin-2-yl)propyl)pyridine-2,4-dicarboxamide; \n (S*)-6-Benzyl-N 2 -methyl-N 4 -(3-(2-methylmorpholin-2-yl)propyl)pyridine-2,4-dicarboxamide; \n 6-Benzyl-N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N2-ethylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((R*)-hydroxy(p-tolyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4S *)-hydroxy(p-tolyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((R*)-hydroxy(o-tolyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4S *)-hydroxy(o-tolyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((S*)-1-(indolin-4-yl)ethyl)-N2-methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((R*)-1-(indolin-4-yl)ethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-6-((S*)-(2-chlorophenyl)(hydroxy)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-6-4R*)-(2-chlorophenyl)(hydroxy)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-((1H-Indol-4-yl)methyl)-N 4 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N2-ethylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-((R*)-1-(2-oxoindolin-4-yl)ethyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 2 -methyl-6-((S*)-1-(2-oxoindolin-4-yl)ethyl)pyridine-2,4-dicarboxamide; \n N 4 -(3-((2r,5r)-5-Amino-1,3-dioxan-2-yl)propyl)-6-(3-chlorobenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -(3-((2r,5r)-5-Amino-1,3-dioxan-2-yl)propyl)-6-(2-chlorobenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -(3-((2r,5r)-5-Amino-1,3-dioxan-2-yl)propyl)-N 2 -methyl-6-(3-methylbenzyl)pyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4S*)-hydroxy(m-tolyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((R*)-hydroxy(m-tolyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -(3-((2r,5r)-5-Amino-1,3-dioxan-2-yl)propyl)-6-(methoxy(phenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4S*)-(3-fluorophenyl)(hydroxy)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-4R*)-(3-fluorophenyl)(hydroxy)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -(3-((2r,5r)-5-Amino-1,3-dioxan-2-yl)propyl)-6-(2-methoxybenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(4-fluorobenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -(3-((2r,5S)-5-Amino-1,3-dioxan-2-yl)propyl)-6-((S*)-methoxy(phenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -(3-((2r,5S)-5-Amino-1,3-dioxan-2-yl)propyl)-6-((R*)-methoxy(phenyl)methyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n 6-Benzyl-N 4 -(3-((2r,5r)-5-(dimethylamino)-1,3-dioxan-2-yl)propyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(2-cyano-1-phenylethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n (+/\u2212)-tert-Butyl 4-(3-(2-benzyl-6-(methylcarbamoyl)isonicotinamido)propyl)-3,3-difluoropiperidine-1-carboxylate; \n (+/\u2212)-N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-(2-fluoro-1-phenylethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((S*)-2-fluoro-1-phenylethyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n N 4 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-6-((R*)-2-fluoro-1-phenylethyl)-N 2 -methylpyridine-2,4-dicarboxamide; or \n N 4 -(3-((2r,5r)-5-Amino-1,3-dioxan-2-yl)propyl)-6-(3-methoxybenzyl)-N 2 -methylpyridine-2,4-dicarboxamide; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 97.0
- Lexical Diversity: 1.125
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16091577', '15762229', '15757199', '15766222', '15374047']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.81480554330815
- 35 USC 102 Novelty (BERT): 0.5658030620682698
- Combined Prediction Score: 0.789905295184162
- Mean Citation Score: 431.95859800000005
- Max Citation Score: 523.9435
- Similarity Product: 308.532635582447

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test