PATENT CLAIM ANALYSIS

Application Number: 16195005
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["435", "325000"]

Abstract:
A method of obtaining a neural multipotent, unipotent or somatic cell, including: i) providing a cell of a first type which is not a neural multipotent, unipotent or somatic cell; ii) increasing expression of at least one neural multipotent or unipotent gene regulator in the cell of a first type, to a level at which the at least one neural multipotent or unipotent gene regulator is capable of driving transformation of the cell of a first type into the neural multipotent, unipotent or somatic cell, wherein the at least one multipotent or unipotent gene regulator is Musashi1 (Msi1), Neurogenin 2 (Ngn2), or both Msi1 and Ngn2; and iii) placing or maintaining the cell in a neural cell culture medium and maintaining sufficient intracellular levels of the at least one multipotent or unipotent gene regulator for a sufficient period of time to allow a stable neural multipotent, unipotent or somatic cell to be obtained.

Claim (Index 5):
The method of  claim 1 , wherein the neural multipotent, unipotent or somatic cell so obtained possesses one or more of the following characteristics:\n i) expression of one or more neural lineage cell marker selected from the group consisting of Sox2, Nestin, Glial Fibrillary acidic protein (GFAP), \u03b2III tubulin, Msi1 and Ngn2; ii) form neurospheres in a neurosphere colony formation assay; iii) is capable of differentiation into at least one cell expressing a marker specific for a neuronal, astrocyte or oligodendrocyte cell; iv) has one or more morphological neurite processes selected from the group consisting of axons and dendrites, wherein the neurite processes are greater than one cell diameter in length upon neuronal differentiation; v) expression of at least one neural-specific antigen selected from the group consisting of neural-specific microtubule associated protein 2 (Map2), neural cell adhesion molecule (NCAM), and a marker for a neurotransmitter upon neuronal differentiation; vi) expression of one or more functional neural markers upon neuronal differentiation; vii) capable of releasing one or more neurotrophic factors; viii) capable of significantly improving one or more neurological functional measures after placement of an adequate number of the said neural multipotent or unipotent cells into the void in a brain ablation model; ix) capable of significantly improving or maintaining one or more neurological functional measures after injecting an adequate number of the said neural multipotent or unipotent cells into an Experimental Allergic Encephalomyelitis (EAE) mouse model; and x) capable of improving one or more neurological functional measures more significantly than human fetal neuroprogenitor cells (hNPCs) in central nervous system injury or neurodegenerative models.

Metadata:
- Claim Count in Document: 33.0
- Percentile: 98.0
- Lexical Diversity: 2.70312
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15297972', '15298006', '13504988', '15298034', '15275921']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8674505863361596
- 35 USC 102 Novelty (BERT): 0.8100377922578224
- Combined Prediction Score: 0.8617093069283259
- Mean Citation Score: 982.044498
- Max Citation Score: 1064.8004
- Similarity Product: 1046.2585014597416

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test