PATENT CLAIM ANALYSIS

Application Number: 16381557
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-10
Patent Classification: ["424", "093200"]

Abstract:
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a transglutaminase (TGM) polypeptide (e.g., a Transglutaminase-1 (TGM1) polypeptide); viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.

Claim (Index 17):
The method of  claim 15 , wherein the one or more signs or symptoms of ARCI are selected from the group consisting of an abnormal stratum corneum, incomplete thickening of the cornified cell envelope, defects in the intercellular lipid layers in the stratum corneum, generalized scaling with variable redness of the skin, formation of large plate-like scales, accelerated epidermal turnover, palmoplantar hyperkeratosis, defective barrier function, recurrent skin infections, exposure keratitis, hypohidrosis, heat intolerance, corneal perforation, rickets, nail abnormalities, dehydration, respiratory problems, ectropion, eclabium, hypoplasia of joint and nasal cartilage, hypotrichosis, scarring alopecia, renal insufficiency, sepsis, and any combinations thereof.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 100.0
- Lexical Diversity: 1.55263
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15393151', '16177153', '15851488', '11166438', '10766897']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8019979258809794
- 35 USC 102 Novelty (BERT): 0.5672988959174032
- Combined Prediction Score: 0.7785280228846218
- Mean Citation Score: 443.620332
- Max Citation Score: 520.2533
- Similarity Product: 318.4213717323422

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test