PATENT CLAIM ANALYSIS

Application Number: 15980431
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "533000"]

Abstract:
The present disclosure provides methods for adjusting the dosage of PAA prodrugs (e.g., HPN-100, PBA) based on measurement of PAA and PAGN in plasma and calculating the PAA:PAGN ratio so as to determine whether PAA to PAGN conversion is saturated.

Claim (Index 18):
A method for treating a urea cycle disorder in a subject in need thereof while minimizing the risk of the subject suffering an adverse event related to PAA accumulation, comprising:\n administering to the subject glycerol triphenylbutyrate; determining the ratio of plasma PAA:PAGN following said administration; and comparing said ratio to a predetermined target level, wherein, when said ratio exceeds said target level, said subject is determined to have an enhanced risk of suffering an adverse event related to PAA accumulation and the method further comprises: administering to the subject a decreased amount of glycerol triphenylbutyrate.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 93.0
- Lexical Diversity: 1.27027
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13610580', '12350111', '14958259', '13417137', '13775000']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8209639456855341
- 35 USC 102 Novelty (BERT): 0.5959773510623902
- Combined Prediction Score: 0.7984652862232197
- Mean Citation Score: 452.6015100000001
- Max Citation Score: 534.13275
- Similarity Product: 355.9547960823924

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test