PATENT CLAIM ANALYSIS

Application Number: 15746617
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "365000"]

Abstract:
Provided is an EP2 agonist having excellent safety. A compound represented by general formula (I) (wherein all symbols are as defined in the description), a salt or N-oxide of the compound, or a solvate or prodrug of the compound or the salt or N-oxide has an EP2 agonist activity and is highly safe, and is therefore useful as a medicine, particularly a therapeutic agent for diseases associated with EP2 receptors, such as immune diseases, allergic diseases, neuronal death, dysmenorrhea, premature birth, miscarriage, baldness, ocular diseases, erectile dysfunction, arthritis, lung injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, bone diseases and cartilage injury.

Claim (Index 1):
A compound represented by general formula (I): wherein ring 1 represents a 5- or 6-membered monocyclic aromatic ring; R 1  represents \u2014(CH 2 ) p \u2014COOH, \u2014(CH 2 ) q \u2014COOR 11 , \u2014(CH 2 ) r \u2014OH, \u2014(CH 2 ) s \u2014OR 12 , \u2014CH 2 NR 13 R 14  or \u2014CONR 13 R 14 ; p represents an integer of 0 to 4; q represents an integer of 0 to 4; r represents an integer of 1 to 4; s represents an integer of 1 to 4; R 11  represents a C1-4 alkyl group; R 12  represents a C1-4 alkyl group or a C1-4 acyl group; R 13  represents a hydrogen atom or a C1-4 alkyl group and R 14  represents a hydrogen atom, a C1-4 alkyl group, a C1-4 acyl group, or a R 15 O(C\u2550O)\u2014C1-4 alkylene group, or R 13 , R 14  and a nitrogen atom to which R 13  and R 14  are bound together represent a saturated 5- to 8-membered cyclic amine group; R 15  represents a hydrogen atom or a C1-4 alkyl group; X represents \u2014O\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, or \u2014NR 16 \u2014; R 16  represents a hydrogen atom, a C1-4 alkyl group, or a C1-4 acyl group; R 2  represents a hydrogen atom, or a C1-4 alkyl group; R 3  represents a hydrogen atom, a halogen atom, or \u2014OR 31 ; R 31  represents a hydrogen atom, a C1-4 alkyl group, or a C1-4 acyl group; n represents an integer of 1 or 2; R 3 's may be the same as or different from each other when n represents 2; E represents \u2014O\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014CH 2 \u2014, \u2550CH\u2014, or \u2014NR 17 \u2014; R 17  represents a hydrogen atom, a C1-4 alkyl group, or a C1-4 acyl group; J represents \u2014(CR 7 R 8 ) m \u2014; m represents an integer of 0 to 4; R 7  and R 8  independently represent a hydrogen atom, a halogen atom, a hydroxy group or a C1-4 alkyl group which may be substituted by a halogen atom, wherein two or more R 7 's and R 8 's may be the same as or different from each other, or R 7  and R 8  on the same carbon atom and the carbon atom to which R 7  and R 8  are bound may together form a C3-6 saturated carbon ring; Q represents a bond, \u2014CH 2 \u2014, \u2014O\u2014, \u2014O\u2014CH 2 \u2014, \u2014S\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, or \u2014NR 18 \u2014; R 18  represents a hydrogen atom, a C1-4 alkyl group, or a C1-4 acyl group; R 4  represents a C1-4 alkyl group, a C2-4 alkenyl group, a C2-4 alkynyl group, or a 3- to 15-membered ring, wherein the 3- to 15-membered ring may be substituted by 0 to 5 R 5 's; R 5  represents (1) a C1-8 alkyl group, (2) a C2-8 alkenyl group, (3) a C2-8 alkynyl group, (4) a C3-8 cycloalkyl group, (5) a C1-8 alkoxy group, (6) a C3-8 cycloalkyloxy group, (7) a C1-8 acyl group, (8) a C1-8 acyloxy group, (9) a C1-8 alkylthio group, (10) a C3-8 cycloalkylthio group, (11) a C1-8 alkylsulfinyl group, (12) a C3-8 cycloalkylsulfinyl group, (13) a C1-8 alkylsulfonyl group, (14) a C3-8 cycloalkylsulfonyl group, (15) a C1-8 alkoxycarbonyl group, (16) a 5- or 6-membered cyclic group, (17) a (5- or 6-membered cyclic group)-C1-4 alkyl group, (18) a (5- or 6-membered cyclic group)-C1-4 alkoxy group, (19) a (5- or 6-membered cyclic group)-C1-4 acyl group, (20) a halogen atom, (21) a hydroxy group, (22) a nitro group, (23) a cyano group, (24) \u2014NR 51 R 52 , (25) \u2014CONR 53 R 54 , or (26) \u2014SO 2 NR 55 R 56 ; R 51 , R 52 , R 53 , R 54 , R 55  and R 56  independently represent a hydrogen atom, a C1-8 alkyl group, a C1-8 acyl group, or a C1-8 alkylsulfonyl group; R 5 's may be the same as or different from each other when the 3- to 15-membered ring is substituted by multiple R 5 's, wherein each of the groups (1) to (19) for R 5  may be substituted by 1 to 3 R 6 's; R 6  represents a C1-4 alkyl group, a C1-4 alkoxy group, a C1-4 acyl group, a C3-8 cycloalkyl group, OH, \u2014NR 61 R 62 , or a halogen atom, wherein R 6 's may be the same as or different from each other when each of the groups (1) to (19) is substituted by multiple R 6 's; R 61  and R 62  independently represent a hydrogen atom or a C1-4 alkyl group; and the following bond independently represents a single bond or a double bond; salt or N-oxide of the compound, or a solvate or prodrug of the compound, the salt or the N-oxide.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 86.0
- Lexical Diversity: 1.71053
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13982052', '15121882', '12944326', '13982001', '15581834']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7610380329959878
- 35 USC 102 Novelty (BERT): 0.603817677811941
- Combined Prediction Score: 0.7453159974775831
- Mean Citation Score: 407.633602
- Max Citation Score: 555.88837
- Similarity Product: 437.56423119424704

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test