PATENT CLAIM ANALYSIS

Application Number: 15909521
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["544", "331000"]

Abstract:
The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a ubiquitin ligase binder. The methods of the present invention comprise administering to the subject an pharmaceutically effective amount of at least one compound of the invention.

Claim (Index 21):
A method of treating or preventing a disease or disorder associated with overexpression and/or uncontrolled activation of c-Abl and/or BCR-ABL, the method comprising administering to the subject a therapeutically effective amount of at least one compound of formula (I):\n TKI-L-(ULM) k \u2003\u2003(I), wherein:\n TKI is a tyrosine kinase inhibitor, \n L is a linker, \n each ULM is independently a ubiquitin ligase binder, and \n k is an integer ranging from 1 to 4, \n wherein TKI is covalently linked to L and wherein each ULM is covalently linked to L, wherein TKI is capable of binding to c-ABL and/or BCR-ABL or a salt, enantiomer, stereoisomer, solvate, polymorph or N-oxide thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 90.0
- Lexical Diversity: 1.58824
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15341275', '14822309', '13211026', '15881318', '15400766']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7413323021520334
- 35 USC 102 Novelty (BERT): 0.6742866975784683
- Combined Prediction Score: 0.7346277416946768
- Mean Citation Score: 345.960142
- Max Citation Score: 831.4325
- Similarity Product: 638.5165763047337

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test