PATENT CLAIM ANALYSIS

Application Number: 15743424
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["546", "276700"]

Abstract:
The invention provides compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D 1 , D 2 , D 3 , X, Y, A 1 , A 2 , R 1 , R 5  and the subscript a are as described herein. The compounds are CETP inhibitors and are useful for raising FIDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:

Claim (Index 5):
The compound of  claim 4  having Formula 1a, or a pharmaceutically acceptable salt thereof: wherein X is \u2014C(\u2550O)\u2014; Y is CH 2  or S; R 1  is CF 3 , F, or \u2014N(CH 3 ) 2 ; D 1  is N or CR 2 , wherein R 2  is H or C 1 -C 3 alkyl; D 2  is N or CR 3 , wherein R 3  is H or CH 3 ; D 3  is N or CR 4 , wherein R 4  is H or CH 3 ; A 1  is phenyl, pyridinyl, thienyl, furyl, cyclohexenyl, or cyclopentenyl, wherein A 1  is optionally substituted with 1-3 groups which are each independently F, C 1 , \u2014OCH 3 , isopropyl, \u2014CN, \u2014CH 3 , or CF 3 , and optionally one substituent group Z; Z is A 3 , \u2014CH 2 CH 2 CO 2 R 8 , \u2014CH 2 CH 2 -(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl), or \u2014CH 2 CH 2 -(5-amino-1,3,4-oxadiazol-2-yl); R 8  is H or \u2014CH 3 ; A 3  is phenyl, cyclobutyl, cyclopentyl, cyclohexyl, or HET(1), wherein HET(1) is pyridinyl, 6-oxopiperidinyl, 2-oxo-1,3-oxazolidinyl, 2-oxo-1,3-oxazinanyl, 5-oxopyrrolidinyl, -(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl), or -(5-amino-1,3,4-oxadiazol-2-yl) wherein A 3  is optionally substituted with 1-2 groups \u2014CH 3 , \u2014OCH 3 , or \u2014OH, and is optionally substituted with 1 group which is \u2014CO 2 R 8  or \u2014C(\u2550O)NHcyclopropyl which is optionally substituted with 1-3 groups independently selected from one \u2014CN and 1-3 halogens; and A 2  is phenyl or pyridinyl, wherein A 2  is substituted with 1 or 2 groups which are each independently CF 3 , CH 3 , F, or C 1 .

Metadata:
- Claim Count in Document: 16.0
- Percentile: 86.0
- Lexical Diversity: 1.63043
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14908180', '13660010', '15329284', '15104351', '15028306']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8423334044254082
- 35 USC 102 Novelty (BERT): 0.5670309184332045
- Combined Prediction Score: 0.8148031558261878
- Mean Citation Score: 434.067694
- Max Citation Score: 454.36414
- Similarity Product: 420.3739313139761

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test