PATENT CLAIM ANALYSIS

Application Number: 16167337
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "345000"]

Abstract:
Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.

Claim (Index 9):
The method of  claim 8 , wherein the liquid nebulizer:\n (i) after administration of the inhaled dose, achieves lung deposition of at least 7% of the pirfenidone or pyridone analog compound administered to the mammal; (ii) provides a Geometric Standard Deviation (GSD) of emitted droplet size distribution of the aqueous solution of about 1.0 \u03bcm to about 2.5 \u03bcm; (iii) provides:\n a) a mass median aerodynamic diameter (MMAD) of droplet size of the aqueous solution emitted with the high efficiency liquid nebulizer of about 1 \u03bcm to about 5 \u03bcm; \n b) a volumetric mean diameter (VMD) of about 1 \u03bcm to about 5 \u03bcm; and/or \n c) a mass median diameter (MMD) of about 1 \u03bcm to about 5 \u03bcm; \n (iv) provides a fine particle fraction (FPF=%\u22645 \u03bcm) of droplets emitted from the liquid nebulizer of at least about 30%; (v) provides an output rate of at least 0.1 mL/min; and/or (vi) provides at least about 25% of the aqueous solution to the mammal.

Metadata:
- Claim Count in Document: 77.0
- Percentile: 97.0
- Lexical Diversity: 1.85484
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13950110', '16042366', '15495806', '14593935', '13363311']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.852985991932156
- 35 USC 102 Novelty (BERT): 0.6769816249207147
- Combined Prediction Score: 0.8353855552310119
- Mean Citation Score: 637.8292160000002
- Max Citation Score: 678.9841299999998
- Similarity Product: 656.3660785522578

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test