PATENT CLAIM ANALYSIS

Application Number: 16137324
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-07
Patent Classification: ["506", "009000"]

Abstract:
Provided herein are methods for determining a diagnosis and/or prognosis for prostate cancer using the ratio of FOXC1:FOXA1 in a sample obtained from a subject.

Claim (Index 54):
A method for determining the prognosis of a prostate cancer in a subject diagnosed as having prostate cancer, comprising:\n (i) obtaining a tissue sample from said subject, wherein said tissue sample comprises prostate cancer cells; (ii) determining the level of FOXA1 protein or nucleic acid in said tissue sample, (iii) determining the level of FOXC1 protein or nucleic acid in said tissue sample, (iv) calculating the ratio of said FOXC1 protein or nucleic acid to said FOXA1 protein or nucleic acid; (v) comparing said ratio to a comparable FOXC1:FOXA1 ratio in a reference population of samples comprising prostate cancer cells in which a prognostic outcome is associated with each of the reference population samples; and (vi) identifying said subject as having a poor prognosis relative to the prognostic outcome when the FOXC1:FOXA1 ratio of the subject is equal to or greater than a FOXC1:FOXA1 cutoff ratio, and identifying said subject as having a good prognosis relative to the prognostic outcome when the FOXC1:FOXA1 ratio of the subject is less than the FOXC1:FOXA1 cutoff ratio, wherein the FOXC1:FOXA1 cutoff ratio corresponds to at least the 50th percentile of FOXC1:FOXA1 ratios of the reference population.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 97.0
- Lexical Diversity: 1.12
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15617333', '14909916', '15271988', '13483176', '13320283']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5484858455662631
- 35 USC 102 Novelty (BERT): 0.5260816984648786
- Combined Prediction Score: 0.5462454308561246
- Mean Citation Score: 270.179616
- Max Citation Score: 342.38446
- Similarity Product: 251.5222798070752

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test