PATENT CLAIM ANALYSIS

Application Number: 16000717
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-11
Patent Classification: ["424", "001650"]

Abstract:
A molecular probe for labeling myelin includes a fluorescent trans-stilbene derivative.

Claim (Index 20):
A method of detecting a myelin related disorder in an animal, the method comprising the steps of:\n (i) administering to an animal's brain a molecular probe including the general formula: wherein R 1  and R 2  are each independently a hydrophilic or lipophilic group; wherein X 1  is a double or triple bond; each R 4 -R 13  is independently selected from the group consisting of H, F, Cl, Br, I, a lower alkyl group, an alkylene group, an alkenyl group, an alkynyl group, an alkoxy group, an aryl group, an aryloxy group, an alkaryl group, an aralkyl group, O, (CH 2 ) n OR\u2032 (wherein n=1, 2, or 3), CF 3 , CH 2 \u2014CH 2 X, O\u2014CH 2 \u2014CH 2 X, CH 2 \u2014CH 2 \u2014CH 2 X, O\u2014CH 2 \u2014CH 2 X (wherein X=F, Cl, Br, or I), CN, C\u2550O, (C\u2550O)\u2014R\u2032, N(R\u2032) 2 , NO 2 , (C\u2550O)N(R\u2032) 2 , O(CO)R\u2032, OR\u2032, SR\u2032, COOR\u2032, R ph , CR\u2032\u2550CR\u2032\u2014R ph , CR 2 \u2032\u2014CR 2 \u2032\u2014R ph  (wherein R ph  represents an unsubstituted or substituted phenyl group, wherein R\u2032 is H or a lower alkyl group); wherein R 10  and R 11  and/or R 12  and R 13  may be linked to form a cyclic ring, wherein the cyclic ring is aromatic, alicyclic, heteroaromatic, or heteroalicyclic; or a pharmaceutically acceptable salt thereof; (ii) visualizing a distribution of the molecular probe in the animal's tissue; and (iii) correlating the distribution of the molecular probe with a myelin related disorder in the animal.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 94.0
- Lexical Diversity: 1.0
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13121742', '13284288', '13806795', '10859600', '14595949']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7636798743391808
- 35 USC 102 Novelty (BERT): 0.5962419852386128
- Combined Prediction Score: 0.746936085429124
- Mean Citation Score: 375.933968
- Max Citation Score: 540.7916
- Similarity Product: 455.5323907894612

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test