PATENT CLAIM ANALYSIS

Application Number: 15910708
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-02
Patent Classification: ["514", "210180"]

Abstract:
The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I: or pharmaceutically acceptable salts thereof.

Claim (Index 1):
A method of treating a disease selected from autoimmune hemolytic anemia pemphigus, and myelofibrosis in a patient, comprising administering to said patient a therapeutically effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein:\n R 2  is C 1-6  alkyl or C 1-6  haloalkyl; \n R 4  is halo, OH, CN, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, or C 1-4  haloalkoxy; \n R 5  is halo, OH, CN, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, or C 1-4  haloalkoxy; \n Cy is selected from C 3-7  cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl, each of which is optionally substituted with 1, 2, 3, or 4 independently selected R 3  groups; \n each R 3  is independently selected from Cy 1 , \u2014(C 1-3  alkylene)-Cy 1 , halo, CN, NO 2 , C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, OR a1 , SR a1 , C(\u2550O)R b1 , C(\u2550O)NR c1 R d1 , C(\u2550O)OR a1 , OC(\u2550O)R b1 OC(\u2550O)NR c1 R d1 , NR c1 R d1 , NR c1 C(\u2550O)R b1 , NR c1 C(\u2550O)OR b1 , NR c1 C(\u2550O)NR c1 R d1 , C(\u2550NR e )R b1 , C(\u2550NR e )NR c1 R d1 , NR c1 C(\u2550NR e )NR c1 R d1 , NR c1 S(\u2550O)R b1 , NR c1 S(\u2550O) 2 NR c1 R d1 , S(\u2550O)R b1 , S(\u2550O) 2 R b1 , and S(\u2550O) 2 NR c1 R d1 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 11  groups; \n each Cy 1  is independently selected from C 3-7  cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl, each of which is optionally substituted with 1, 2, 3, or 4 independently selected R 11  groups; each R a1 , R c1 , and R d1  is independently selected from H, C 1-6  alkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, 4-7 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl are each optionally substituted with 1, 2, or 3 independently selected R 11  groups; each R b1  is independently selected from C 1-6  alkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally substituted with 1, 2, or 3 independently selected R 11  groups; or R c1  and R d1  together with the N atom to which they are attached form a 4-, 5-, 6-, or 7 membered heterocycloalkyl group, which is optionally substituted with \u2014OH or C 1-3  alkyl; each R e  is independently selected from H, CN, OH, C 1-4  alkyl, and C 1-4  alkoxy; and each R 11  is independently selected from OH, NO 2 , CN, halo, C 1-3  alkyl, C 2-3  alkenyl, C 2-3  alkynyl, C 1-3  haloalkyl, cyano-C 1-3  alkyl, HO\u2014C 1-3  alkyl, C 1-3  alkoxy-C 1-3  alkyl, C 3-7  cycloalkyl, C 1-3  alkoxy, C 1-3  haloalkoxy, amino, C 1-3  alkylamino, di(C 1-3  alkyl)amino, thio, C 1-3  alkylthio, C 1-3  alkylsulfinyl, C 1-3  alkylsulfonyl, carbamyl, C 1-3  alkylcarbamyl, di(C 1-3  alkyl)carbamyl, carboxy, C 1-3  alkylcarbonyl, C 1-4  alkoxycarbonyl, C 1-3  alkylcarbonylamino, C 1-3  alkylsulfonylamino, aminosulfonyl, C 1-3  alkylaminosulfonyl, di(C 1-3  alkyl)aminosulfonyl, aminosulfonylamino, C 1-3  alkylaminosulfonylamino, di(C 1-3  alkyl)aminosulfonylamino, aminocarbonylamino, C 1-3  alkylaminocarbonylamino, and di(C 1-3  alkyl)aminocarbonylamino.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 90.0
- Lexical Diversity: 1.04762
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13854789', '14872881', '14193481', '15902742', '15065409']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7681895136903102
- 35 USC 102 Novelty (BERT): 0.5761257470265256
- Combined Prediction Score: 0.7489831370239317
- Mean Citation Score: 455.550562
- Max Citation Score: 494.76465
- Similarity Product: 368.5494741676212

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test