PATENT CLAIM ANALYSIS

Application Number: 16441209
Application Type: Utility
Filing Date: 2019-06
Publication Date: 2020-01
Patent Classification: ["435", "440000"]

Abstract:
Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.

Claim (Index 12):
The method of  claim 1  wherein the target nucleic acid is genomic DNA, mitochondrial DNA, viral DNA or exogenous DNA.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 100.0
- Lexical Diversity: 3.14894
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14319289', '15049451', '14903728', '14674895', '14213479']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7013919168890992
- 35 USC 102 Novelty (BERT): 0.6913897712525533
- Combined Prediction Score: 0.7003917023254446
- Mean Citation Score: 661.2157340000001
- Max Citation Score: 746.9967
- Similarity Product: 701.0594655213475

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test