PATENT CLAIM ANALYSIS

Application Number: 16121475
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["424", "134100"]

Abstract:
The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

Claim (Index 11):
A method of treating a target antigen-associated disease in an individual in need thereof comprising administering to the individual an effective amount of a composition comprising an effector \u03b1\u03b2 T cell comprising an abTCR that specifically binds to the target antigen, wherein the abTCR comprises:\n a) a first polypeptide chain comprising a first antigen-binding domain comprising a V H  antibody domain and a first TCRD comprising a first transmembrane domain of a first TCR subunit; and \n b) a second polypeptide chain comprising a second antigen-binding domain comprising a V L  antibody domains and a second TCRD comprising a second transmembrane domain of a second TCR subunit, \n wherein the V H  domain of the first antigen-binding domain and the V L  domain of the second antigen-binding domain form an antigen-binding module that specifically binds to the target antigen, \n wherein the first TCRD and the second TCRD form a T cell receptor module (TCRM) that is capable of recruiting at least one TCR-associated signaling module, and \n wherein the first TCR subunit is a TCR \u03b3 chain and the second TCR subunit is a TCR \u03b4 chain, or the first TCR subunit is a TCR \u03b4 chain and the second TCR subunit is a TCR \u03b3 chain.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 97.0
- Lexical Diversity: 1.13158
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15829793', '15829783', '15419398', '15965738', '15965739']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6687227418371934
- 35 USC 102 Novelty (BERT): 0.6796518755699473
- Combined Prediction Score: 0.6698156552104688
- Mean Citation Score: 463.286966
- Max Citation Score: 780.8609
- Similarity Product: 631.5183001911045

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test