PATENT CLAIM ANALYSIS

Application Number: 16016955
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "496000"]

Abstract:
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

Claim (Index 1):
A compound of formula (I) or a salt thereof wherein: R 1  is C 1-4 alkyl; R 2  is C 1-4 alkyl, C 3-7 cycloalkyl, \u2014CH 2 CF 3 , \u2014CH 2 OCH 3  or heterocyclyl; R 3  is C 1-4 alkyl, \u2014CH 2 F, \u2014CH 2 OH or \u2014CH 2 OC(O)CH 3 ; R 4  when present is H, hydroxy, halo, cyano, \u2014CO 2 H, \u2014CONH 2 , \u2014OSO 2 CF 3 , \u2014C(O)N(R 8 )C 1-4 alkyleneOH, \u2014C(O)N(R 8 )C 1-4 alkyleneOCH 3 , \u2014C(O)N(R 8 )C 1-4 alkyleneNR 6 R 7 , \u2014C(O)N(R 8 )C 1-4 alkyleneSO 2 CH 3 , \u2014C(O)N(R 8 )C 1-4 alkyleneCN, \u2014C(O)NHOH, \u2014C(O)NHCH(CH 2 OH) 2 , \u2014OCH 2 CH 2 OH, \u2014B\u2014C 1-6 alkyl, \u2014B\u2014C 3-7 cycloalkyl, \u2014B-phenyl, \u2014B-heterocyclyl or \u2014B-heteroaromatic, wherein the C 3-7 cycloalkyl, phenyl, heterocyclyl or heteroaromatic ring is optionally substituted by 1 or 2 substituents independently selected from \u2550O, C 1-6 alkyl, C 1-6 alkoxy, halo, \u2014NH 2 , \u2014CO 2 H, \u2014C(O)C 1-6 alkyl, \u2014C(O)NHC 1-6 alkyl, cyano, \u2014CH 2 CH 2 NHCH 3 , \u2014CH 2 CH 2 OH, \u2014CH 2 CH 2 OCH 3 , C 3-7 cycloalkyl, phenyl, heterocyclyl and heteroaromatic; R 5  when present is H, halo, hydroxy or C 1-6 alkoxy; A is \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014N(C 1-4 alkyl)- or \u2014NC(O)(CH 3 )\u2014; B is a bond, \u2014O\u2014, \u2014N(R 8 )\u2014, S, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014SO 2 N(R 8 )\u2014, \u2014CH 2 \u2014, \u2014C(O)\u2014, \u2014CO 2 \u2014, \u2014N(R 8 )C(O)\u2014, \u2014C(O)N(R 8 )\u2014, \u2014C(O)N(R 8 )CH 2 \u2014 or \u2014C(O)N(R 8 )CH 2 CH 2 \u2014; V is phenyl, heteroaromatic or pyridone any of which may be optionally substituted by 1, 2 or 3 substituents independently selected from C 1-6 alkyl, fluorine, chlorine, C 1-6 alkoxy, hydroxy, cyclopropyl, cyano, \u2014CO 2 CH 3 , heterocyclyl, \u2014CO 2 H, \u2014CH 2 NR 6 R 7 , \u2014NR 6 R 7 , \u2014C(O)NR 6 R 7 , \u2014NR 6 C(O)R 7 , \u2014CF 3 , \u2014NO 2 , \u2014CH 2 OCH 3 , \u2014CH 2 OH, \u2014CH(OH)CH 3 , \u2014SO 2 CH 3 , \u2014CH 2 heterocyclyl, \u2014OCH 2 CH 2 NHC(O)CH 3 , \u2014OCH 2 CH 2 OH, \u2014OCH 2 CH 2 NH 2 , \u2014C(O)NHheteroaromatic, \u2014C(O)NHCH 2 heterocyclyl, \u2014C(O)NHCH 2 CH 2 OH, \u2014C(O)NHCH 2 CH 2 NH 2 , \u2014C(O)NHCH 2 CH 2 SO 2 Me, \u2014C(O)NHCH 2 CH(OH)CH 3 , \u2014C(O)heterocyclyl and \u2014C(O)NHheterocyclyl, wherein the heterocyclyl ring is optionally substituted by \u2014OH; R 6 , R 7 , R 8 , R 9  and R 10  are each independently selected from H and C 1-4 alkyl; W is CH or N; X is C or N; Y is C or N; and Z is CH or N; subject to the proviso that no more than 2 of W, X, Y and Z are N; and that the compound of formula (I) is not 1-(2-ethyl-3-methyl-4-(phenylamino)-3,4-dihydroquinolin-1(2H)-yl)ethanone or 1-(2-ethyl-3-methyl-4-(phenylamino)-3,4-dihydroquinolin-1(2H)-yl)propan-1-one.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 94.0
- Lexical Diversity: 1.11111
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14770499', '15466925', '14111625', '14111580', '13503947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7891769013278508
- 35 USC 102 Novelty (BERT): 0.5422045954048965
- Combined Prediction Score: 0.7644796707355554
- Mean Citation Score: 359.96987
- Max Citation Score: 371.13324
- Similarity Product: 270.03465711743115

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test