PATENT CLAIM ANALYSIS

Application Number: 16001883
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "001890"]

Abstract:
The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders, including inflammatory and renal disorders.

Claim (Index 11):
A compound of Formula (I): or pharmaceutically acceptable salt thereof,\n wherein: \n Z is CH; \n R 1  is a member selected from the group consisting of: \u2014H, \u2014C 1-3 alkyl and \u2014C 1-3 haloalkyl; \n Y is \u2014C(R a ) 2 \u2014, where each R a  is independently selected from the group consisting of: \u2014H, \u2014F, \u2014CH 3 , \u2014OH and \u2014N(R b ) 2 ; \n R 2  is a member selected from the group consisting of:\n A) six-membered monocyclic heteroaromatic ring containing one or two nitrogen members unsubstituted or substituted with one or two members each independently selected from the group consisting of: halo, \u2014C 1-3 alkyl, \u2014C 1-3 haloalkyl, \u2014CN, \u2014OH, \u2014C(R b ) 2 OH, \u2014CH 2 NH 2 , \u2014C(R b ) 2 CN, \u2014C(R b ) 2 CONH 2 , \u2014OCH 2 CONH 2 , \u2014OC 1-3 alkyl, \u2014OCH 2 C(R b ) 2 OH, \u2014OCH 2 cyclopropyl, \u2014OC 1-3 haloalkyl, \u2014CO 2 H, \u2014CON(R b ) 2 , \u2014N(R b ) 2 , \u2014NHCH 2 CF 3 , \u2014NHCH(CH 3 ) 2 , \u2014NHCH 2 CH 2 N(CH 3 ) 2 , \u2014NHCH 2 CH 2 OH, \u2014NHcyclopropyl, \u2014NHCOCH 3 , morpholinyl, pyrrolidin-3-ol, and azetidin-3-ol; \n B) five-membered monocyclic heteroaromatic ring containing two, three, or four nitrogen members unsubstituted or substituted with one or two members each independently selected from the group consisting of halo, \u2014C 1-3 alkyl, \u2014C 1-3 haloalkyl, \u2014C(R b ) 2 OH, \u2014N(R b ) 2 , \u2014NO 2 , \u2014CN, \u2014CH 2 CN, \u2014OC 1-3 alkyl, \u2014CH 2 OCH 3 , \u2014CH 2 CH 2 OH, \u2014CH 2 NH 2 , \u2014CH 2 CONH 2 , \u2014CO 2 C 1-3 alkyl, \u2014CO 2 H, \u2014CONH 2 , \u2014NHCOCH 3 , and cyclopropyl; and \n C) five or six-membered ring selected from: 1,2-dihydro-pyridin-2-one, thiazole or 1,2-oxazole unsubstituted or substituted with one or two members each independently selected from the group consisting of \u2014CH 3 , and \u2014NH 2 ; \n \n R 3  is phenyl or pyridine, each substituted with one or two members each independently selected from the group consisting of: -halo, \u2014C 1-3 alkyl, \u2014OC 1-3 alkyl, -Ocyclopropyl, \u2014O-oxetane, \u2014C 1-3 haloalkyl, \u2014OC 1-3 haloalkyl, \u2014CN, \u2014CH 2 OH, \u2014SO 2 CH 3 , or \u2014N(CH 3 ) 2 ; \n R 4  is a member selected from the group consisting of \u2014C 1-3 alkyl and \u2014C 1-3 haloalkyl; and \n each R b  is independently selected from \u2014H or \u2014CH 3 ;

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 1.71212
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14720321', '14204934', '15306069', '14408942', '15579878']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.813107328671581
- 35 USC 102 Novelty (BERT): 0.6174867394181494
- Combined Prediction Score: 0.7935452697462378
- Mean Citation Score: 433.971856
- Max Citation Score: 566.7744
- Similarity Product: 457.0365393442154

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test