PATENT CLAIM ANALYSIS

Application Number: 15910745
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "451000"]

Abstract:
Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain pharmacokinetic parameters and methods for treating, prophylaxis, or amelioration of neurodegenerative diseases including multiple sclerosis using such compositions in a subject, wherein if the compositions contain dimethyl fumarate, the total amount of dimethyl fumarate in the compositions ranges from about 43% w/w to about 95% w/w.

Claim (Index 31):
The method of  claim 30 , wherein the compound that metabolizes to monomethyl fumarate is a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein\n R 1  and R 2  are independently chosen from hydrogen, C 1-6  alkyl, and substituted C 1-6  alkyl; \n R 3  and R 4  are independently chosen from hydrogen, C 1-6  alkyl, substituted C 1-6  alkyl, C 1-6  heteroalkyl, substituted C 1-6  heteroalkyl, C 4-12  cycloalkylalkyl, substituted C 4-12  cycloalkylalkyl, C 7-12  arylalkyl, and substituted C 7-12  arylalkyl; or R 3  and R 4  together with the nitrogen to which they are bonded form a ring chosen from a C 5-10  heteroaryl, substituted C 5-10  heteroaryl, C 5-10  heterocycloalkyl, and substituted C 5-10  heterocycloalkyl; and \n R 5  is chosen from methyl, ethyl, and C 3-6  alkyl; \n wherein each substituent group is independently chosen from halogen, \u2014OH, \u2014CN, \u2014CF 3 , \u2550O, \u2014NO 2 , benzyl, \u2014C(O)NR 11 2 , \u2014R 11 , \u2014OR 11 , \u2014C(O)R 11 , \u2014COOR 11 , and \u2014NR 11 2  wherein each R 11  is independently chosen from hydrogen and C 1-4  alkyl; \n with the proviso that when R 5  is ethyl; then R 3  and R 4  are independently chosen from hydrogen, C 1-6  alkyl, and substituted C 1-6  alkyl.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.38462
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15686352', '15125612', '15248506', '15299535', '15582913']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.733256526764602
- 35 USC 102 Novelty (BERT): 0.5168296950581278
- Combined Prediction Score: 0.7116138435939545
- Mean Citation Score: 226.95391400000003
- Max Citation Score: 236.01488
- Similarity Product: 128.07805697275165

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test