PATENT CLAIM ANALYSIS

Application Number: 15742027
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["427", "002100"]

Abstract:
An asymmetric immobilization process that immobilizes a one or more receptor biomolecules on one or more solid surfaces is provided. The asymmetric immobilization process includes the following steps: (i) activating the one or more solid surfaces using an oxidizing agent; (ii) treating the one or more solid surfaces with aminosilane to obtain a one or more amine functionalized solid surfaces; (iii) treating the one or more receptor biomolecules with a 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) to obtain a one or more site-specific EDC activated receptor biomolecules; and (iv) immobilizing the one or more site-specific EDC activated receptor biomolecules on a first layer of the one or more amine functionalized solid surfaces, wherein the immobilizing comprises treating the one or more site-specific EDC activated receptor biomolecules with amine groups of the first layer of the one or more amine functionalized solid surfaces to form a covalent amide bond.

Claim (Index 4):
The asymmetric immobilization process as claimed in  claim 1 , wherein the asymmetric immobilization process is performed using a micromanipulation injector, and wherein the asymmetric immobilization process comprises:\n positioning the one or more amine-functionalized solid surfaces on a microscopic stage; filling, a microneedle of the micromanipulation injector, with the one or more EDC activated receptor biomolecules; adjusting the position of the microneedle and the one or more solid surfaces; setting, using the micromanipulation injector, a desired injection pressure based on the volume of the one or more EDC activated receptor biomolecules to be dispensed on the first region of the one or more solid surfaces; setting, using the micromanipulation injector, an injection time; pressing an inject button of the micromanipulation injector to regulate a flow of nitrogen gas; releasing a measured amount of the one or more EDC activated receptor biomolecules on the first region of the one or more solid surfaces; and incubating the one or more amine-functionalized solid surfaces with the one or more EDC activated receptor biomolecules for 10-60 mins.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 86.0
- Lexical Diversity: 2.66129
- Patent Class: 427.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12317713', '10293260', '12119203', '11621209', '09845742']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8059633069771127
- 35 USC 102 Novelty (BERT): 0.5103717558666614
- Combined Prediction Score: 0.7764041518660676
- Mean Citation Score: 198.672414
- Max Citation Score: 231.09346
- Similarity Product: 144.2411791564131

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test