PATENT CLAIM ANALYSIS

Application Number: 16027029
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["548", "400000"]

Abstract:
Provided herein are Mcl-1 antagonist compositions and methods of treating cancer using the compositions described herein.

Claim (Index 86):
A method of treating cancer in a subject in need thereof, said method comprising administering to the subject an effective amount of a compound having the formula: wherein,\n L 1 , L 2 , L 3 , L 4 , L 5 , and L 6  are independently a bond, \u2014C(O)\u2014, \u2014C(O)O\u2014, \u2014C(O)NR 7 \u2014, \u2014O\u2014, \u2014S(O) n \u2014, \u2014S(O)NR 7 \u2014, \u2014C(O)NR 7 S(O) 2 \u2014, \u2014NR 7 \u2014, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; \n R 7  is independently hydrogen, halogen, \u2014N 3 , \u2014NO 2 , \u2014CF 3 , \u2014CCl 3 , \u2014CBr 3 , \u2014CI 3 , \u2014CN, \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 2 Cl, \u2014SO 3 H, \u2014SO 2 Ph, \u2014SO 2 NH 2 , \u2014NHNH 2 , \u2014ONH 2 , \u2014OCH 3 , \u2014NHCNHNH 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n n is 0, 1, or 2; \n R 1  is halogen, \u2014N 3 , \u2014CF 3 , \u2014CCl 3 , \u2014CBr 3 , \u2014CI 3 , \u2014CN, \u2014CHO, \u2550O, \u2014OR 1A , \u2014NR 1B R 1C , \u2014COOR 1A , \u2014CONR 1B R 1C , \u2014NO 2 , \u2014SR 1D , \u2014SO n1 R 1B , \u2014S(O) n1 OR 1B , \u2014S(O) n1 NR 1B R 1C , \u2014NHNR 1B R 1C , \u2014ONR 1B R 1C , \u2014NHC(O)NHNR 1B R 1C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R 1  and R 2  are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 2  is hydrogen, halogen, \u2014N 3 , \u2014CF 3 , \u2014CCl 3 , \u2014CBr 3 , \u2014CI 3 , \u2014CN, \u2014CHO, \u2550O, \u2014OR 2A , \u2014NR 2B R 2C , \u2014COOR 2A , \u2014CONR 2B R 2C , NO 2 , SR 2D , \u2014SO n2 R 2B , \u2014SO n2 OR 2B , \u2014SO n2 NR 2B R 2C , \u2014NHNR 2B R 2C , \u2014ONR 2B R 2C , \u2014NHC(O)NHNR 2B R 2C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R 2  and R 3  are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 3  is hydrogen, halogen, \u2014N 3 , \u2014CF 3 , \u2014CCl 3 , \u2014CBr 3 , \u2014CI 3 , \u2014CN, \u2014CHO, \u2550O, \u2014OR 3A , \u2014NR 3B R 3C , \u2014COOR 3A , \u2014CONR 3B R 3C , NO 2 , SR 3D , \u2014SO n3 R 3B , \u2014SO n3 OR 3B , \u2014SO n3 NR 3B R 3C , \u2014NHNR 3B R 3C , \u2014ONR 3B R 3C , \u2014NHC(O)NHNR 3B R 3C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R 3  and R 4  are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 4  is hydrogen, halogen, \u2014N 3 , \u2014CF 3 , \u2014CCl 3 , \u2014CBr 3 , \u2014CI 3 , \u2014CN, \u2014CHO, \u2550O, \u2014OR 4A , \u2014NR 4B R 4C , \u2014COOR 4A , \u2014CONR 4B R 4C , NO 2 , SR 4D , \u2014SO n4 R 4B , \u2014SO n4 OR 4B , \u2014SO n4 NR 4B R 4C , \u2014NHNR 4B R 4C , \u2014ONR 4B R 4C , \u2014NHC(O)NHNR 4B R 4C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 5  is independently hydrogen, halogen, \u2014N 3 , \u2014CF 3 , \u2014CCl 3 , \u2014CBr 3 , \u2014CI 3 , \u2014CN, \u2014CHO, \u2550O, \u2014OR 5A , \u2014NR 5B R 5C , \u2014COOR 5A , \u2014CONR 5B R 5C , NO 2 , SR 5D , \u2014SO n5 R 5B , \u2014SO n5 OR 5B , \u2014SO n5 NR 5B R 5C , \u2014NHNR 5B R 5C , \u2014ONR 5B R 5C , \u2014NHC(O)NHNR 5B R 5C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R 5  and R 6  are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 6  is hydrogen, halogen, \u2014N 3 , \u2014CF 3 , \u2014CCl 3 , \u2014CBr 3 , \u2014CI 3 , \u2014CN, \u2014CHO, \u2550O, \u2014OR 6A , \u2014NR 6B R 6C , \u2014COOR 6A , \u2014CONR 6B R 6C , NO 2 , SR 6D , \u2014SO n6 R 6B , \u2014SO n6 OR 6B , \u2014SO n6 NR 6B R 6C , \u2014NHNR 6B R 6C , \u2014ONR 6B R 6C , \u2014NHC(O)NHNR 6B R 6C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n R 1A , R 2A , R 3A , R 4A , R 5A , R 6A , R 1B , R 2B , R 3B , R 4B , R 5B , R 6B , R 1C , R 2C , R 3C , R 4C , R 5C , R 6C , R 1D , R 2D , R 3D , R 4D , R 5D , and R 6D  are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R 6B  and R 6C , are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; \n n1, n2, n3, n4, n5, and n6 are independently 1 or 2; and \n z is 1 or 2.

Metadata:
- Claim Count in Document: 245.0
- Percentile: 95.0
- Lexical Diversity: 1.13333
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15123232', '15662861', '15700040', '15214282', '15421258']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8083749547219371
- 35 USC 102 Novelty (BERT): 0.6302414313126347
- Combined Prediction Score: 0.7905616023810069
- Mean Citation Score: 615.5831919999998
- Max Citation Score: 733.3489
- Similarity Product: 514.588629736185

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test