PATENT CLAIM ANALYSIS

Application Number: 15890990
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "047000"]

Abstract:
2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

Claim (Index 1):
A compound of the Formula (XIII) or (XIV): or a pharmaceutically acceptable salt thereof, wherein:\n R 3  is selected from the group consisting of H; mono-, di-, and tri-phosphate or a stabilized phosphate prodrug; acyl; a sulfonate ester; optionally substituted alkyl sulfonyl; optionally substituted arylsulfonyl; a lipid; an amino acid; a carbohydrate; a peptide; cholesterol; and a pharmaceutically acceptable leaving group which when administered in vivo is capable of providing a compound wherein R 3  is independently H, or mono-, di- or triphosphate; \n B indicates a Spiro compound selected from the group consisting of optionally substituted carbocycle or optionally substituted heterocycle; \n Base is selected from the group consisting of: \n wherein\n each R\u2032, R\u2033, R\u2032\u2033 and R\u2033\u2033 are independently selected from the group consisting of H, OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, Br-vinyl, \u2014O-alkyl, O-alkenyl, O-alkynyl, O-aryl, O-aralkyl, \u2014O-acyl, O-cycloalkyl, NH 2 , NH-alkyl, N-dialkyl, NH-acyl, N-aryl, N-aralkyl, NH-cycloalkyl, SH, S-alkyl, S-acyl, S-aryl, S-cycloalkyl, S-aralkyl, F, Cl, Br, I, CN, COOH, CONH 2 , CO 2 -alkyl, CONH-alkyl, CON-dialkyl, OH, CF 3 , CH 2 OH, (CH 2 ) m OH, (CH 2 ) m NH 2 , (CH 2 ) m COOH, (CH 2 ) m CN, (CH 2 ) m NO 2  and (CH 2 ) m CONH 2 ; \n m is 0 or 1; \n W is C\u2014R\u2033 or N; \n T and V independently are CH or N; \n Q is CH, \u2014CCl, \u2014CBr, \u2014CF, \u2014CI, \u2014CCN, \u2014C\u2014COOH, \u2014C\u2014CONH 2 , or N; \n Q 1  and Q 2  independently are N or C\u2014R; \n R is H, alkyl, or acyl; and \n Q 3 , Q 4 , Q 5  and Q 6  independently are N or CH.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 88.0
- Lexical Diversity: 1.88333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13168895', '11005473', '10261244', '11005447', '10715729']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8091068589028981
- 35 USC 102 Novelty (BERT): 0.5737231407807853
- Combined Prediction Score: 0.7855684870906868
- Mean Citation Score: 378.14248
- Max Citation Score: 446.71884000000006
- Similarity Product: 440.0246937932897

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test