PATENT CLAIM ANALYSIS

Application Number: 15743546
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["546", "153000"]

Abstract:
Compounds that inhibit Myeloid Cell Leukemia-1 (Mcl-1) oncoprotein, and methods of using the same, are provided for treating disease.

Claim (Index 1):
A compound comprising formula (I): wherein X 1  is a substituent selected from the group consisting of H, C, CH, CH 2 , and CH 3 ; X 2  is a substituent selected from the group consisting of C, CH, and CH 2 , and n=0 or 1; X 3  is a substituent selected from the group consisting of N, CH, and CH 2 , and m=0 or 1; X 4  is a substituent selected from the group consisting of C, CH, N, and NR 2 , wherein the dashed lines can independently represent a single bond, a double bond, or no bond; A is a substituent selected from the group consisting of S(\u2550O), S(\u2550O) 2 , C(\u2550O), C(\u2550O)O, and CH 2 ; L is a bond or an NR 3  substituent; each Z can independently represent a substituent selected from the group consisting of H, halo, cyano, hydroxy, nitro, and optionally substituted acylsulfonamide, alkyl, alkylaryl, alkylhetaryl, alkylheterocycloalkyl, alkenyl, alkynyl, alkenyl-cycloalkyl, alkynyl-cycloalkyl, carbonyl, carboxaldehyde, carboxyl, cycloalkyl, cycloalkyl-alkenyl, cycloalkyl-heterocycloalkyl, cycloalkyl-heteroaryl, alkoxy, alkoxycarbonyl, acyl, acyloxy, amino, amido, aryl, aralkyl, ester, fluoroalkyl, heteroalkyl, heteroalkenyl, heteroalkynyl, heteroalkylaryl, heteroalkylheteroaryl, heteroalkylheterocycloalkyl, heteroalkylcycloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, hydroxamate, and heterocycloalkyl; Y 1  and Y 2  each can independently represent a substituent selected from the group consisting of H, OR 4 , CONR 4 R 4 , CONR 4 OR 4 , CONR 4 \u2014SO 2 R 4 , COOR 4 , and optionally substituted alkyl, aryl, and heteroaryl, and q=0 or 1, and t=0 or 1; each R 1 , R 2 , R 3 , and R 4  can independently represent a substituent selected from the group consisting of H and optionally substituted alkyl, cycloalkyl, sulfinyl, sulfonyl, and aryl; and R 1  and R 3  can, taken together, comprise an optionally substituted cycloalkyl or heterocycloalkyl ring; and pharmaceutically acceptable salts, solvates, hydrates, cocrystals, or prodrugs thereof; with the proviso that if (1) X 1 , X 2 , X 3 , and X 4  together form part of a benzene ring, (2) Y 1  is OH or O-alkyl and q=1, (3) A is S(\u2550O) 2  or C(\u2550O), and (4) L is NR 3 , then Y 2  is COOR 4  and t=1.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 86.0
- Lexical Diversity: 1.04348
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12104294', '12096393', '14763468', '13823810', '13526337']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7405267719958342
- 35 USC 102 Novelty (BERT): 0.512809100487315
- Combined Prediction Score: 0.7177550048449822
- Mean Citation Score: 268.77087199999994
- Max Citation Score: 276.15472
- Similarity Product: 190.24752791118613

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test