PATENT CLAIM ANALYSIS

Application Number: 15961531
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "001100"]

Abstract:
Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

Claim (Index 9):
The immunoconjugate of  claim 8 , wherein:\n L 1  is selected from \u2014*C(\u2550O)(CH 2 ) m \u2014, \u2014(CH 2 ) m \u2014, \u2014*(CH 2 ) m X 3 (CH 2 ) m \u2014, \u2014*C(\u2550O)X 1 X 2 C(\u2550O)(CH 2 ) m \u2014, \u2014*((CH 2 ) m O) n (CH 2 ) m X 3 (CH 2 ) m \u2014, \u2014*(CH 2 ) m NHC(\u2550O)X 1 X 2 C(\u2550O)(CH 2 ) m \u2014, \u2014*X 4  X 1 X 2 C(\u2550O)(CH 2 ) m \u2014, \u2014*X 1 C(\u2550O)(CH 2 ) m NHC(\u2550O)(CH 2 ) m \u2014, \u2014*(CH 2 ) m C(\u2550O)NH(CH 2 ) m NHC(\u2550O)(CH 2 ) m \u2014, \u2014*S(\u2550O) 2 (CH 2 ) m X 3 (CH 2 ) m \u2014, \u2003\u2014*NHS(\u2550O) 2 (CH 2 ) m X 3 (CH 2 ) m \u2014, \u2014*C(\u2550O)((CH 2 ) m O) n (CH 2 ) m \u2014 and \u2014*C(\u2550O)NH(CH 2 ) m \u2014, wherein the * indicates the point of attachment to R 3 ;\n L 2  is \n \u2003wherein the * indicates the point of attachment to L 1 , and L 3 , L 4 , L 5  and L 6  are a bond.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 91.0
- Lexical Diversity: 1.75862
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15104727', '15822930', '15524197', '16098289', '14305643']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8046651825612549
- 35 USC 102 Novelty (BERT): 0.6507603899919653
- Combined Prediction Score: 0.7892747033043259
- Mean Citation Score: 488.761508
- Max Citation Score: 729.10266
- Similarity Product: 555.5217918957925

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test