PATENT CLAIM ANALYSIS

Application Number: 16176352
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-08
Patent Classification: ["424", "001730"]

Abstract:
The present invention provides an in vivo imaging method that facilitates the diagnosis of Acute Lymphoblastic Leukemia (ALL) at an early stage. Early diagnosis is particularly advantageous as a tool to select more aggressive therapy, to estimate the success rate for visualizing ALL at the time of diagnosis.

Claim (Index 30):
The method of  claim 21 , further comprising producing the in vivo imaging agent comprising said radiolabeled 3\u2032 substituted nucleoside analog, wherein producing comprises the steps of:\n (i) labelling a protected precursor compound with 18F; \n (ii) deprotecting the 18F-labelled compound obtained in step (i) by hydrolysis; \n (iii) diluting the deprotected 18F-labelled compound obtained in step (ii) with water; \n (iv) trapping the deprotected 18F-labelled compound on a solid-phase extraction (SPE) column by passing the diluted solution obtained in step (iii) through said column; \n (v) eluting the deprotected 18F-labelled compound from the SPE column; with the proviso that no neutralising step is carried out following the deprotection step;\n wherein producing said in vivo imaging agent comprises producing at least a detectable quantity of said in vivo imaging agent that when administered to said mammalian subject enters the cells and becomes phosphorylated to produce a detectable species; and \n wherein producing said in vivo imaging agent is carried out in temporal proximity to administering said in vivo imaging agent to said mammalian subject.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 97.0
- Lexical Diversity: 1.23256
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12234478', '11629607', '12448102', '14119539', '13596632']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6805241986364164
- 35 USC 102 Novelty (BERT): 0.4665716662482073
- Combined Prediction Score: 0.6591289453975956
- Mean Citation Score: 129.044966
- Max Citation Score: 130.87474
- Similarity Product: 95.20493274505496

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test