PATENT CLAIM ANALYSIS

Application Number: 16147871
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["435", "285200"]

Abstract:
In an illustrative embodiment, automated instruments comprising one or more flow-through electroporation devices or modules are provided to automate transformation of nucleic acids in live cells.

Claim (Index 11):
An automated instrument comprising an FTEP module, wherein the automated instrument comprises:\n a housing configured to house all of some of the modules; a receptacle configured to receive cells; a growth module for growing the cells; one or more receptacles configured to receive nucleic acids; the flow-through electroporation (FTEP) module, wherein the FTEP module is configured to introduce the nucleic acids into the cells; and wherein the FTEP module comprises:\n a. at least one inlet and at least one inlet channel for introducing a fluid comprising cells and nucleic acid to the FTEP module; \n b. an outlet and an outlet channel for removing transformed cells and nucleic acid from the FTEP module; \n c. a flow channel positioned between a first inlet channel and the outlet channel, wherein the flow channel intersects with the first inlet channel and the outlet channel and wherein a portion of the flow channel narrows between the inlet channel intersection and the outlet channel intersection; and \n d. an electrode positioned on either side of the flow channel and in direct contact with the fluid in the flow channel, the electrodes defining the narrowed portion of the flow channel; and wherein the electrodes apply one or more electric pulses to the cells in the fluid as they pass through the flow channel, thereby introducing the nucleic acid into the cells in the fluid; \n a processor configured to operate the automated instrument based on user input and/or selection of a pre-programmed script; and an automated liquid handling system to move liquids from the cell receptacle to the growth module, and from the growth module to the FTEP module, as well as from the one or more nucleic acid receptacles to the FTEP module, all without user intervention.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 97.0
- Lexical Diversity: 1.03704
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16147865', '16147120', '16147353', '16024816', '15283922']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.563486896324163
- 35 USC 102 Novelty (BERT): 0.5834700874438861
- Combined Prediction Score: 0.5654852154361354
- Mean Citation Score: 336.25913
- Max Citation Score: 479.35696
- Similarity Product: 440.4923169465638

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test