PATENT CLAIM ANALYSIS

Application Number: 15925517
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "210180"]

Abstract:
This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.

Claim (Index 27):
A compound represented by: wherein:\n p is 0, 1, or 2; \n R d  is selected from the group consisting of: H, C 1-6 alkyl (optionally substituted by one, two or three halogens, or hydroxyl) or R a R b N\u2014C(O)\u2014. \n L 3  is selected from the group consisting of: a bond, C 1 -C 6 alkylene, \u2014C(O)\u2014, C 1 -C 6 alkylene-C(O)\u2014, C 1 -C 6 alkylene-O\u2014C(O)\u2014, NR a \u2014C(O)\u2014C 1 -C 6 alkylene-, \u2014S(O) w \u2014, and C 1 -C 6 alkylene-S(O) w \u2014, wherein w is 0, 1, or 2, and wherein C 1 -C 6 alkylene is optionally substituted by one or two substituents selected from the group consisting of: halogen, hydroxyl, cyano, and an additional R 7 ; \n R 7  is selected from the group consisting of: H, phenyl, naphthyl, mono or bicyclic heteroaryl or mono or bicyclic heterocycle, wherein the heteroaryl or heterocycle has 1, 2 or 3 heteroatoms independently selected from O, S, or N; wherein R 7  is optionally substituted by one, two, three or four moieties independently selected from the group consisting of halogen, phenyl (optionally substituted by one, two, or three moieties each independently selected from R c ), phenyloxy (optionally substituted by one, two, or three moieties each independently selected from R c ), hydroxyl, cyano, C 1-6 alkyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl), C 2-6 alkenyl (optionally substituted by one, two or three halogens, cyano, or hydroxyl), C 1-6 alkoxy (optionally substituted by one, two or three halogens, cyano, or hydroxyl), R a R b N\u2014, R a \u2014C(O)NR a \u2014, R a R b N\u2014SO w \u2014 (wherein w is 0, 1 or 2); R a R b N\u2014C(O)\u2014, R a \u2014S(O) w \u2014 (wherein w is 0, 1 or 2), R a \u2014S(O) w \u2014NR b \u2014 (wherein w is 0, 1 or 2), heteroaryl (optionally substituted by one, two or three moieties each independently selected from R c ) or heteroaryloxy (optionally substituted by one, two, or three moieties each independently selected from R c );\n R a  and R b  may be independently selected, for each occurrence, from the group consisting of hydrogen and C 1-3 alkyl; wherein C 1-3 alkyl may optionally be substituted by one or more substituents selected from halogen, cyano, oxo, hydroxyl, heterocycle, and phenyl; \n \n or R a  and R b , when they occur together with the nitrogen to which they are attached, form a 4-6 membered heterocyclic ring or a 9-10 membered bicyclic heterocycle or spirocyclic ring, which may have an additional heteroatom selected from O, S, or N; wherein the 4-6 membered heterocyclic ring or 9-10 membered bicyclic heterocycle or spirocycle may optionally be substituted by one or more substituents selected from the group consisting of halogen, cyano, oxo, C 1-6 alkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), hydroxyl, \u2014NH 2 , and NH\u2014C(O)\u2014C 1-6 alkyl; \n R c  is selected from the group consisting of halogen, cyano, hydroxyl, nitro, C 1-6 alkyl (optionally substituted by one, two, or three halogens, cyano, or hydroxyl), C 2-6 alkenyl (optionally substituted by one, two, or three halogens), C 3-6 cycloalkyl, C 1-6 alkoxy (optionally substituted by one, two, or three halogens), R a R b N\u2014, R a R b N\u2014SO 2 \u2014, R a R b N\u2014C(O)\u2014, R a \u2014C(O) w \u2014NR a \u2014, R a \u2014C(O)\u2014, R a \u2014S(O) w \u2014NR b \u2014 (wherein w is 0, 1 or 2), or R a \u2014S(O) w \u2014 (wherein w is 0, 1 or 2); \n T is CX 3  or X is independently for each occurrence halogen or H; V is O or NR a ; R V  is selected from the group consisting of hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3-6 cycloalkyl, phenyl, heteroaryl, and heterocyclyl, or when R a  and R v  occur together with the nitrogen to which they are attached, form a 4-6 membered heterocyclic ring which may have an additional heteroatom selected from O, S, or N; wherein C 1 -C 6 alkyl, C 2 -C 6 alkenyl, phenyl, heterocyclic ring and heterocyclyl are optionally substituted by one, two, or three moieties independently selected from the group consisting of halogen, hydroxyl, C 1 -C 6 alkyl, cyano, phenyl; or pharmaceutically acceptably salts or stereoisomers thereof.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 90.0
- Lexical Diversity: 1.32203
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14599105', '14369982', '15272313', '14902324', '14383076']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8421920836235024
- 35 USC 102 Novelty (BERT): 0.5520678506290617
- Combined Prediction Score: 0.8131796603240584
- Mean Citation Score: 391.818716
- Max Citation Score: 428.7739
- Similarity Product: 344.1045528907538

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test