PATENT CLAIM ANALYSIS

Application Number: 15575903
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "230800"]

Abstract:
The present invention discloses a pyrido-azacyclic compound represented by formula I, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a preparation process thereof and a composition comprising the compound, and a use thereof as a multi-target protein kinase inhibitor in the preparation of a medicament for the treatment of diseases that are associated with protein kinase, especially c-Met, such as cancer and the like. The compound represented by formula I has potent inhibitory activity on tumor cells with overexpression of c-Met kinase, can effectively target c-Met-mediated signaling pathway, and can be used in the treatment of diseases such as cancer and the like that is caused by the overexpression of c-Met kinase.

Claim (Index 2):
The compound, the isomer thereof and the pharmaceutically acceptable salt or the pharmaceutically acceptable solvate thereof according to  claim 1 , wherein,\n R 1  and R 2  are each independently selected from hydrogen, F, Cl and Br; X is absent, or X and Y are each independently selected from C, N and O; n is 0, 1 or 2; m is 0 or 1; R 3  is absent, or is hydrogen, a substituted or unsubstituted C 1 -C 6  alkyl, a substituted or unsubstituted C 6 -C 10  aryl, a substituted or unsubstituted 5- or 6-membered saturated or unsaturated heterocyclic group containing 1 to 2 heteroatoms selected from N, O and S, a substituted or unsubstituted 5- or 6-membered saturated or unsaturated heterocyclic carbonyl group containing 1 to 2 heteroatoms selected from N, O and S, or a substituted or unsubstituted 5- or 6-membered heteroaromatic ring group containing 1 to 2 heteroatoms selected from N and O, wherein, the number of the substituents may be 1 or 2 and the substituents are each independently selected from halogen, \u2014CN, benzyl, \u2014NO 2 , C 1 -C 6  alkyl, amino substituted by C 1 -C 6  alkyl, C 1 -C 6  alkylsulfonyl and an unsubstituted or C 1 -C 6  alkyl-substituted 5- or 6-membered saturated or unsaturated heterocyclic group containing 1 to 2 heteroatoms selected from N and O;\n R 6  is absent, or is selected from hydrogen and C 1 -C 4  alkyl; \n R 7  is absent, or is selected from hydrogen, methyl, ethyl and propyl; \n R 4  is selected from hydrogen and C 1 -C 6  alkyl; R 5  and R 5\u2032  are each independently selected from hydrogen, F, Cl, Br and C 1 -C 4  alkoxy.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 91.0
- Lexical Diversity: 1.92424
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14916177', '14763468', '13509442', '13801753', '14383803']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.754835935154287
- 35 USC 102 Novelty (BERT): 0.5460229593570224
- Combined Prediction Score: 0.7339546375745606
- Mean Citation Score: 360.248268
- Max Citation Score: 382.27582
- Similarity Product: 277.2659563737536

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test