PATENT CLAIM ANALYSIS

Application Number: 15755618
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "048000"]

Abstract:
Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application thereof in preparing medicine. Crystal forms I and II of the fludarabine phosphate have excellent properties in terms of solubleness, dissolution rate, chemical stability, and processing adaptability.

Claim (Index 3):
A preparation method of the crystal form I of 9-\u03b2-D-arabinofuranosyl-2-fluoroadenine-5\u2032-phosphate according to  claim 1 , wherein the method is selected from any one of the following methods;\n method 1), comprising the following steps of: (1) 9-\u03b2-D-arabinofuranosyl-2-fluoroadenine-5\u2032-phosphate is added to an acidic aqueous solution; (2) dissolved; (3) the pH is adjusted with an alkaline solution, wherein the pH is less than 1.2, preferably in the pH range of 0-1.0; (4) crystallized; (5) filtered to obtain crystal form I of 9-\u03b2-D-arabinofuranosyl-2-fluoroadenine-5\u2032-phosphate; method 2), comprising the following steps of: (1) 9-\u03b2-D-arabinofuranosyl-2-fluoroadenine-5\u2032-phosphate is added to an alkaline aqueous solution; (2) dissolved; (3) the DH is adjusted with an acidic solution, wherein the DH is less than 1.2, preferably in the pH range of 0-1.0; (4) crystallized; (5) filtered to obtain crystal form I of 9-\u03b2-D-arabinofuranosyl-2-fluoroadenine-5\u2032-phosphate; method 3), comprising the following steps of: (1) the fermentation broth containing 9-\u03b2-D-arabinofuranosyl-2-fluoroadenine-5\u2032-phosphate is filtered; (2) the filtrate is added to a crystallizer; (3) the pH is adjusted with an acidic solution, wherein the pH is less than 1.2, preferably in the pH range of 0-1.0; (4) crystallized; (5) filtered to obtain crystal form I of 9-\u03b2-D-arabinofuranosyl-2-fluoroadenine-5\u2032-phosphate.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 88.0
- Lexical Diversity: 1.36585
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15760090', '15762895', '15328795', '15123378', '16098103']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7696390059119697
- 35 USC 102 Novelty (BERT): 0.5018239117059641
- Combined Prediction Score: 0.7428574964913691
- Mean Citation Score: 231.988772
- Max Citation Score: 248.48439
- Similarity Product: 172.756396135903

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test