PATENT CLAIM ANALYSIS

Application Number: 15768352
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["424", "450000"]

Abstract:
Irinotecan phospholipid liposomes with improved storage stability are provided, with related methods of treatment and manufacture. The irinotecan liposomes can have reduced formation of lyso-phosphatidylcholine (lyso-PC) during storage, and prior to administration to a patient.

Claim (Index 19):
The liposomal irinotecan composition of  claim 2 , made by a process comprising steps of:\n (a) forming a lipid dispersion in a solution of TEA 8 SOS having a sulfate concentration of about 0.45 M and a pH of about 6.5, the lipids in said dispersion consisting of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol and methoxy-terminated polyethylene glycol (MW 2000)-distearoylphosphatidyl ethanolamine (MPEG-2000-DSPE) in a molar ratio of 3:2:0.015, respectively; (b) extruding the lipid dispersion at a temperature ranging from 60-70\u00b0 C. through at least one 0.1 \u03bcm membrane to form liposomes; (c) removing ions derived from TEA 8 SOS that are outside the liposomes; (d) contacting the liposomes at a temperature ranging from 60-70\u00b0 C. with a solution made using irinotecan hydrochloride trihydrate, to form a preparation of liposomes encapsulating about 500 g (\u00b110%) irinotecan per mol total liposome phospholipid; (e) removing substances derived from the TEA 8 SOS and irinotecan ingredients that are outside the liposomes; and (f) adjusting the pH of the composition to be about 7.3.

Metadata:
- Claim Count in Document: 77.0
- Percentile: 91.0
- Lexical Diversity: 1.24242
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15798287', '14395345', '15340761', '15241128', '14965140']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7273808270494659
- 35 USC 102 Novelty (BERT): 0.5520113871499488
- Combined Prediction Score: 0.7098438830595143
- Mean Citation Score: 395.737634
- Max Citation Score: 416.47427000000016
- Similarity Product: 301.5732363317633

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test