PATENT CLAIM ANALYSIS

Application Number: 15933889
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "210200"]

Abstract:
The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Claim (Index 2):
The compound or salt according to  claim 20 , wherein\n Ring A is (1) a benzene ring optionally further substituted by 1 to 3 substituents selected from\n (a) an optionally halogenated C 1-6  alkoxy group, \n (b) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (i) a halogen atom, \n (ii) a hydroxy group, \n (iii) an amino group optionally mono- or di-substituted by substituent(s) selected from\n (I) a C 3-10  cycloalkyl group, and \n (II) a C 1-6  alkoxy-carbonyl group, \n \n (iv) a 5- to 14-membered aromatic heterocyclic group, and \n (v) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkyl groups, \n \n (c) a C 3-10  cycloalkyl group optionally substituted by 1 to 3 substituents selected from\n (i) a 3- to 14-membered non-aromatic heterocyclic group, \n \n (d) a halogen atom, \n (e) a cyano group, \n (f) a carboxy group, \n (g) a C 1-6  alkoxy-carbonyl group, \n (h) a C 1-6  alkylsulfanyl group, \n (i) a C 1-6  alkylsulfonyl group, \n (j) a carbamoyl group optionally mono- or di-substituted by substituent(s) selected from\n (i) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (I) a hydroxy group, \n (II) a halogen atom, \n (III) an optionally halogenated C 1-6  alkoxy group, \n (IV) a mono- or di-C 1-6  alkylamino group, \n (V) a C 3-10  cycloalkyl group, and \n (VI) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from a C 1-6  alkyl group and a C 1-6  alkyl-carbonyl group, \n \n (ii) a C 3-10  cycloalkyl group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, \n (II) an optionally halogenated C 1-6  alkyl group, \n (III) a carboxy group, and \n (IV) a C 1-6  alkoxy-carbonyl group, and \n \n (iii) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 optionally halogenated C 1-6  alkyl groups, \n \n (k) a sulfamoyl group optionally mono- or di-substituted by substituent(s) selected from\n (i) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkyl groups, \n \n (l) a 5- to 14-membered aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkyl groups, \n (m) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (i) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, \n (II) a hydroxy group, \n (III) a cyano group, \n (IV) a carbamoyl group, \n (V) a C 1-6  alkoxy group, \n (VI) a C 1-6  alkylsulfonyl group, \n (VII) a mono- or di-C 1-6  alkylamino group, and \n (VIII) a 3- to 14-membered non-aromatic heterocyclic group, \n \n (ii) a C 1-6  alkyl-carbonyl group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, \n (II) a hydroxy group, and \n (III) a mono- or di-C 1-6  alkylamino group, \n \n (iii) a C 1-6  alkoxy-carbonyl group, \n (iv) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, \n (II) a C 1-6  alkyl-carbonyl group, and \n (III) a C 1-6  alkoxy-carbonyl group, \n \n (v) an oxo group, and \n (vi) a mono- or di-C 1-6  alkyl-carbamoyl group, \n \n (n) a 3- to 14-membered non-aromatic heterocyclylcarbonyl group optionally substituted by 1 to 3 substituents selected from\n (i) a halogen atom, \n (ii) a hydroxy group, \n (iii) a cyano group, \n (iv) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (I) a hydroxy group, \n (II) a halogen atom, \n (III) a C 1-6  alkoxy group, \n (IV) a mono- or di-C 1-6  alkylamino group, and \n (V) a C 3-10  cycloalkyl group, \n \n (v) an optionally halogenated C 1-6  alkoxy group, \n (vi) a C 1-6  alkyl-carbonyl group optionally substituted by 1 to 3 substituents selected from\n (I) a hydroxy group, and \n (II) a C 1-6  alkoxy group, \n \n (vii) a C 1-6  alkoxy-carbonyl group, \n (viii) a C 3-10  cycloalkyl group, \n (ix) a C 3-10  cycloalkyl-carbonyl group, \n (x) a C 1-6  alkylsulfonyl group, and \n (xi) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkyl groups, and \n \n (o) a 3- to 14-membered non-aromatic heterocyclylsulfonyl group optionally substituted by 1 to 3 of 3- to 14-membered non-aromatic heterocyclic groups \n (the two substituents on the benzene ring are optionally bonded to each other to form a 5- or 6-membered monocyclic aromatic heterocycle, a 3- to 8-membered monocyclic non-aromatic heterocycle or a C 5-6  cycloalkene ring, each of which is optionally substituted by 1 to 3 substituents selected from\n (a) an oxo group, \n (b) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (i) a halogen atom, \n (ii) a hydroxy group, \n (iii) a carboxy group, \n (iv) a C 1-6  alkoxy group, \n (v) a C 1-6  alkyl-carbonyl group, \n (vi) a mono- or di-C 1-6  alkylamino group, and \n (vii) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkyl groups, \n \n (c) a C 3-10  cycloalkyl group, \n (d) a formyl group, \n (e) a C 1-6  alkyl-carbonyl group optionally substituted by 1 to 3 substituents selected from\n (i) a halogen atom, \n (ii) a hydroxy group, \n (iii) a C 1-6  alkoxy group, \n (iv) a C 1-6  alkyl-carbonyloxy group, \n (v) a mono- or di-C 1-6  alkylamino group, and \n (vi) a 3- to 14-membered non-aromatic heterocyclic group, \n \n (f) a C 1-6  alkoxy-carbonyl group, \n (g) a 5- to 14-membered aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkyl groups, \n (h) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkyl groups, and \n (i) a 3- to 14-membered non-aromatic heterocyclycarbonyl group optionally substituted by 1 to 3 C 1-6  alkyl groups), \n (2) a pyridine ring optionally further substituted by 1 to 3 substituents selected from\n (a) a C 1-6  alkyl group, \n (b) an optionally halogenated C 1-6  alkoxy group, \n (c) a C 3-10  cycloalkyl group optionally substituted by 1 to 3 halogen atoms, \n (d) an amino group, and \n (e) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (i) a hydroxy group, \n (ii) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, and \n (II) a 3- to 14-membered non-aromatic heterocyclic group, \n \n (iii) an optionally halogenated C 1-6  alkyl-carbonyl group, \n (iv) a C 1-6  alkoxy-carbonyl group, \n (v) a C 3-10  cycloalkyl group optionally substituted by 1 to 3 halogen atoms, and \n (vi) a 3- to 14-membered non-aromatic heterocyclic group, \n \n (3) a pyrimidine ring optionally further substituted by 1 to 3 substituents selected from\n (a) a C 1-6  alkoxy group, and \n (b) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 of 3- to 14-membered non-aromatic heterocyclic groups, \n (4) a pyridazine ring, (5) a pyrazine ring, (6) a pyrazole ring optionally further substituted by 1 to 3 substituents selected from\n (a) a halogen atom, \n (b) a cyano group, \n (c) a carboxy group, \n (d) a C 1-6  alkyl group optionally substituted by 1 to 5 substituents selected from\n (i) a C 3-10  cycloalkyl group optionally substituted by 1 to 3 substituents selected from\n (I) an amino group, \n (II) a hydroxy group, \n (III) an oxo group, \n (IV) a C 1-6  alkyl group, and \n (V) a 3- to 14-membered non-aromatic heterocyclic group, \n \n (ii) a hydroxy group, \n (iii) a cyano group, \n (iv) a halogen atom, \n (v) a carboxy group, \n (vi) a C 1-6  alkoxy group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, and \n (II) a hydroxy group, \n \n (vii) a C 1-6  alkoxy-carbonyl group, \n (viii) a C 1-6  alkylsulfonyl group, \n (ix) an amino group optionally mono- or di-substituted by substituent(s) selected from\n (I) a C 1-6  alkyl-carbonyl group, \n (II) a C 1-6  alkoxy-carbonyl group, \n (III) a C 1-6  alkylsulfonyl group, \n (IV) a C 6-14  aryl-carbonyl group, and \n (V) a carbamoyl group, \n \n (x) a carbamoyl group optionally mono- or di-substituted by substituent(s) selected from\n (I) a C 1-6  alkyl group, and \n (II) a C 6-14  aryl group, \n \n (xi) a 5- to 14-membered aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (I) a C 1-6  alkyl group, and \n (II) a C 1-6  alkoxy group, \n \n (xii) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (I) an oxo group, \n (II) a hydroxy group, \n (III) a carbamoyl group, \n (IV) a C 1-6  alkyl group optionally substituted by 1 to 3 hydroxy groups, \n (V) a C 1-6  alkoxy-carbonyl group, \n (VI) a C 3-10  cycloalkyl group, \n (VII) a C 7-16  aralkyl group, and \n (VIII) a 3- to 14-membered non-aromatic heterocyclic group, and \n \n (xiii) a 3- to 14-membered non-aromatic heterocyclylcarbonyl group, \n \n (e) a C 2-6  alkynyl group, \n (f) a C 1-6  alkoxy group optionally substituted by 1 to 5 substituents selected from\n (i) a halogen atom, and \n (ii) a C 3-10  cycloalkyl group optionally substituted by 1 to 3 halogen atoms, \n \n (g) a C 3-10  cycloalkyl group (the C 3-10  cycloalkyl group is optionally fused with a benzene ring, or optionally bridged or may be a spiro group) optionally substituted by 1 to 3 substituents selected from\n (i) an oxo group, \n (ii) a hydroxy group, \n (iii) a carbamoyl group, \n (iv) a carboxy group, \n (v) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (I) a hydroxy group, \n (II) a carboxy group, \n (III) a carbamoyl group, and \n (IV) a 3- to 14-membered non-aromatic heterocyclic group, \n \n (vi) a C 1-6  alkoxy-carbonyl group, \n (vii) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, \n (II) a hydroxy group, and \n (III) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from a halogen atom and a hydroxy group, and \n \n (viii) an amino group optionally mono- or di-substituted by substituent(s) selected from\n (I) a C 1-6  alkoxy-carbonyl group, and \n (II) a 3- to 14-membered non-aromatic heterocyclic group, \n \n \n (h) an optionally halogenated C 1-6  alkyl-carbonyl group, \n (i) a C 1-6  alkoxy-carbonyl group, \n (j) a C 6-14  aryl group, \n (k) a C 7-16  aralkyl group, \n (l) a 5- to 14-membered aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkoxy groups, \n (m) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (i) an oxo group, \n (ii) a hydroxy group, \n (iii) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, \n (II) a hydroxy group, \n (III) a cyano group, \n (IV) a C 1-6  alkoxy group optionally substituted by 1 to 3 substituents selected from \n \u2003(A) a halogen atom, \n \u2003(B) a C 1-6  alkyl-carbonyloxy group, and \n \u2003(C) a C 1-6  alkoxy-carbonyloxy group, \n (V) a C 1-6  alkyl-carbonyloxy group, \n (VI) a C 3-10  cycloalkyl group, \n (VII) a 5- to 14-membered aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkyl groups, and \n (VIII) a 3- to 14-membered non-aromatic heterocyclic group, \n \n (iv) a C 3-10  cycloalkyl group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, \n (II) a hydroxy group, \n (III) a C 1-6  alkyl group optionally substituted by 1 to 3 C 1-6  alkoxy groups, and \n (IV) a C 1-6  alkoxy group, \n \n (v) a C 6-14  aryl group optionally substituted by 1 to 3 halogen atoms, \n (vi) a C 7-16  aralkyl group, \n (vii) a C 1-6  alkyl-carbonyl group, \n (viii) a C 1-6  alkoxy-carbonyl group, \n (ix) a 5- to 14-membered aromatic heterocyclic group optionally substituted by 1 to 3 C 1-6  alkyl groups, and \n (x) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (I) a halogen atom, \n (II) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from a halogen atom and a C 1-6  alkoxy group, \n (III) a C 3-10  cycloalkyl group, \n (VI) a cyano group, and \n (V) a deuterium atom, \n \n \n (n) a 3- to 14-membered non-aromatic heterocyclyloxy group, and \n (o) a 3- to 14-membered non-aromatic heterocyclylcarbonyl group optionally substituted by 1 to 3 of 3- to 14-membered non-aromatic heterocyclic groups, \n (7) a thiazole ring (the two substituents on the thiazole ring are optionally bonded to each other to form a benzene ring), (8) an isothiazole ring optionally further substituted by 1 to 3 substituents selected from\n (a) a C 1-6  alkyl group optionally substituted by 1 to 3 hydroxy groups, \n (9) an imidazole ring optionally further substituted by 1 to 3 substituents selected from\n (a) a C 1-6  alkyl group optionally substituted by 1 to 3 hydroxy groups \n (the two substituents on the imidazole ring are optionally bonded to each other to form a benzene ring), (10) an isoxazole ring optionally further substituted by 1 to 3 C 1-6  alkyl groups, (11) a thiadiazole ring optionally further substituted by 1 to 3 substituents selected from\n (a) a C 6-14  aryl group optionally substituted by 1 to 3 halogen atoms, or \n (12) a thiophene ring optionally further substituted by 1 to 3 cyano groups (the two substituents on the thiophene ring are optionally bonded to each other to form a C 5-6  cycloalkene ring); Ring B is (1) a pyrimidine ring (X 1  is a carbon atom, X 2  is a carbon atom and X 3  is a nitrogen atom), (2) a pyrazine ring (X 1  is a carbon atom, X 2  is a nitrogen atom and X 3  is a carbon atom), or (3) a pyridine ring (X 1  is a carbon atom, X 2  is a carbon atom and X 3  is a carbon atom); Ring C is (1) a benzene ring optionally further substituted by 1 to 3 halogen atoms, or (2) a pyridine ring (Y 1  is a carbon atom, Y 2  is a carbon atom and Y 3  is a nitrogen atom, or Y 1  is a nitrogen atom, Y 2  is a carbon atom and Y 3  is a carbon atom); Z is (1) \u2014O\u2014, or (2) \u2014NH\u2014; R 1  is (1) a hydrogen atom, (2) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (a) a halogen atom, and \n (b) a hydroxy group, or \n (3) a C 3-10  cycloalkyl group; R 2  is (1) a C 1-6  alkyl group optionally substituted by 1 to 3 substituents selected from\n (a) a 5- to 14-membered aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (i) a cyano group, \n (ii) a halogen atom, \n (iii) a C 1-6  alkyl group, and \n (iv) a C 7-16  aralkyl group, \n \n (b) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (i) an oxo group, and \n (ii) a C 1-6  alkyl group, \n (c) a halogen atom, \n (d) a hydroxy group, \n (e) a cyano group, \n (f) an optionally halogenated C 1-6  alkoxy group, \n (g) a 5- to 14-membered aromatic heterocyclyloxy group, \n (h) a 3- to 14-membered non-aromatic heterocyclyloxy group, \n (i) an amino group optionally mono- or di-substituted by substituent(s) selected from\n (i) a C 1-6  alkyl group, \n (ii) a C 1-6  alkyl-carbonyl group optionally substituted by 1 to 3 C 1-6  alkoxy groups, and \n (iii) a C 1-6  alkylsulfonyl group, and \n \n (j) a mono- or di-C 1-6  alkyl-carbamoyl group, \n (2) a 3- to 14-membered non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from\n (a) an oxo group, and \n (b) a C 1-6  alkyl group, or \n (3) a mono- or di-C 1-6  alkyl-carbamoyl group optionally substituted by 1 to 3 halogen atoms; and R 3  is (1) a cyano group, (2) a halogen atom, (3) an optionally halogenated C 1-6  alkyl group, (4) a carbamoyl group, (5) a mono- or di-C 1-6  alkyl-carbamoyl group, or (6) a 3- to 14-membered non-aromatic heterocyclylcarbonyl group.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 90.0
- Lexical Diversity: 1.35593
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15830634', '13201536', '14404126', '15563161', '15506380']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8412702777726322
- 35 USC 102 Novelty (BERT): 0.5654748830900272
- Combined Prediction Score: 0.8136907383043717
- Mean Citation Score: 428.920974
- Max Citation Score: 449.30573
- Similarity Product: 394.32065067534927

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test