PATENT CLAIM ANALYSIS

Application Number: 15942333
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "211080"]

Abstract:
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Claim (Index 14):
The compound of  claim 13 , wherein A is:\n i. C 3-7  cycloalkyl, C 2-9  heteroaryl, or C 2-9  heterocyclyl, wherein said cycloalkyl, heteroaryl, or heterocyclyl can be optionally substituted with one, two, three or four of R 5 , wherein R 5  is selected from the group consisting of hydrogen, C 1-6  alkyl, C 3-7  cycloalkyl, C 2-6  alkenyl, C 2-6  alkenylene, halogen, cyano, hydroxyl, C 1-6  alkoxy, optionally substituted C 2-9  heteroaryl, \u2014SO 2 R e , \u2014NR e R f , \u2014NR e C(O)R f , \u2014NR e SO 2 R f  and NR e R f \u2014C(O)\u2014; wherein the C 1-6  alkyl, C 3-7  cycloalkyl, C 2-6  alkenyl, C 2-6  alkenylene of R 5  can be optionally substituted with one to four substituents independently selected from the group consisting of C 1-6  alkoxy, hydroxyl, halogen, cyano, \u2014SO 2 R e , \u2014NR e R f \u2014NR e C(O)R f  and \u2014C(O)NR e R f , wherein R e  and R f  in each occurrence are independently selected from the group consisting of hydrogen, branched or linear C 1-6  alkyl and C 3-7  cycloalkyl;\n or, said cycloalkyl or heterocyclyl together with two of R 5  form a bicyclic or spiro ring, wherein two of R 5  attached to different atoms are taken together with the carbon to which each is attached to form a bicyclic, or two of R 5  attached to the same carbon are taken together with the carbon to which each is attached to form a spiro ring; \n ii. \u2014NHR g  or \u2014OR h , wherein R g  and R h  are independently selected from the group consisting of:\n a. branched or linear C 1-6  alkyl, C 1-6  alkenyl, C 1-6  alkenylene, C 2-9  heterocyclyl, and C 3-7  cycloalkyl, wherein said alkyl, alkenyl, alkenylene, heterocyclyl and cycloalkyl can be optionally substituted with one to four substituents independently selected from the group consisting of hydroxyl, halogen, \u2014CHF 2 , \u2014CF 3 , amino, di(C 1-6  alkyl)amino, mono(C 1-6  alkyl)amino, cyano, C 3-7  cycloalkyl, C 1-6  alkoxy, \u2014SO 2 R\u2032, \u2014SO 2 NR\u2032R\u2033, \u2014C(O)NR\u2032R\u2033, \u2014NR\u2032C(O)R\u2033, \u2014NR\u2032C(O)OR\u2033, \u2014NR\u2032C(O)NR\u2033R\u2033\u2032, \u2014NR\u2032SO 2 NR\u2033R\u2032\u2033 or \u2014NR\u2032S(O)R\u2033, wherein R\u2032 and R\u2032\u2033 are independently H or C 1-6  alkyl and R\u2033 is independently C 1-6  alkyl, halo(C 1-6  alkyl) or C 6-10  aryl optionally substituted with C 1-6  alkyl; or R\u2033 and R\u2032\u2033 are taken together with the nitrogen to which they are attached to form a substituted or unsubstituted heterocyclyl; and \n b. C 2-9  heteroaryl or C 6-10  aryl, wherein said heteroaryl has 1-4 heteroatoms selected from O, S and N; and wherein said aryl and heteroaryl can be optionally substituted with one, two, three or four substituents selected from the group consisting of branched or linear C 1-6  alkyl, C 1-6  alkenyl, C 1-6  alkenylene, C 2-9  heterocyclyl, C 3-7  cycloalkyl, hydroxyl, halogen, \u2014CHF 2 , \u2014CF 3 , amino, di(C 1-6  alkyl)amino, mono(C 1-6  alkyl)amino, cyano, C 3-7  cycloalkyl, C 1-6  alkoxy, \u2014SO 2 R\u2032, \u2014SO 2 NR\u2032R\u2033, \u2014C(O)NR\u2032R\u2033, and \u2014NR\u2032C(O)R\u2033, wherein R\u2032 and R\u2033 are independently H or C 1-6  alkyl; or \n iii. C 1-6  alkyl optionally substituted with one to four substituents independently selected from the group consisting of hydroxyl, halogen, cyano, C 1-6  alkoxy, amino, mono(C 1-6  alkyl)amino, di(C 1-6  alkyl)amino, C 3-7  cycloalkyl, C 6-10  aryl, 5-10 membered heteroaryl, 5-10 membered heterocyclyl, \u2014SO 2 R\u2032, \u2014SO 2 NR\u2032R\u2033, \u2014C(O)NR\u2032R\u2033, \u2014NR\u2032C(O)R\u2033, \u2014NR\u2032C(O)OR\u2033, \u2014NR\u2032C(O)NR\u2033R\u2032\u2033, \u2014NR\u2032SO 2 NR\u2033R\u2032\u2033 and \u2014NR\u2032S(O)R\u2033;\n wherein R\u2032 and R\u2032\u2033 are independently H or C 1-6  alkyl and R\u2033 is independently C 1-6  alkyl, halo(C 1-6  alkyl) or C 6-10  aryl optionally substituted with C 1-6  alkyl; or R\u2033 and R\u2032\u2033 are taken together with the nitrogen to which they are attached to form an optionally substituted C 3-7  heterocyclyl.

Metadata:
- Claim Count in Document: 104.0
- Percentile: 90.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15942321', '15698788', '13266976', '15852639', '14428546']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8064646313304608
- 35 USC 102 Novelty (BERT): 0.5299775052370255
- Combined Prediction Score: 0.7788159187211173
- Mean Citation Score: 281.45004400000005
- Max Citation Score: 362.283
- Similarity Product: 324.276705214262

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test