PATENT CLAIM ANALYSIS

Application Number: 15974927
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-11
Patent Classification: ["530", "328000"]

Abstract:
The present disclosure provides light-sensitive protein hydrogels, and methods of their use thereof. The hydrogels can be used for cell encapsulation, culturing, and selective release under appropriate light conditions.

Claim (Index 1):
A light-responsive hydrogel biopolymer matrix comprising:\n (a) one or a plurality of light-responsive gelation initiator complexes comprising the protein photoreceptor CarHc and the multi-dentate ligand adenosylcobalamin, connected to one or a plurality of a first extracellular matrix protein fragments, and (b) two or more cross-linkable proteins connected to one or a plurality of a second extracellular matrix protein fragments, wherein the first extracellular matrix protein fragments and second extracellular matrix protein fragments are independently selected from elastin fragments which comprise a repeating polypeptide having the sequence of (VPGXG) n  (SEQ ID NO: 23), wherein X represents valine or glutamate, the ratio of valine to glutamate ranges from 10:1 to 1:10, n is an integer selected from 2 to 25, the two or more cross-linkable proteins are SpyTag and SpyCatcher, and the matrix is responsive to light comprising a wavelength from about 300 nm to about 600 nm.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.21429
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15542623', '15795585', '13515298', '12814826', '14901216']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6200905049723913
- 35 USC 102 Novelty (BERT): 0.5037919887174441
- Combined Prediction Score: 0.6084606533468966
- Mean Citation Score: 244.22181
- Max Citation Score: 258.73102
- Similarity Product: 195.94158663670183

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test