PATENT CLAIM ANALYSIS

Application Number: 15987365
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "256000"]

Abstract:
This invention provides for an improved method for differentially diagnosing ACTH-dependent Cushing's syndrome. Current practice for differentially diagnosing ectopic ACTH syndrome and Cushing's Disease measures relative ACTH concentrations from the inferior petrosal venous sinus compared to fluid obtained from a periphery venous sample. This is performed before and after administration of exogenous corticotropin releasing factor, or after administration of metyrapone. This invention uses glucocorticoid receptor antagonists to induce release of endogenous CRH which stimulates ACTH to increase in patients with ectopic ACTH syndrome but not in those with Cushing's Disease.

Claim (Index 1):
A method of concurrently treating Cushing's syndrome and obtaining a measurement indicative of differential diagnosis of adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome in a patient where the differential diagnosis is between ectopic ACTH syndrome and Cushing Disease, the method comprising the steps of:\n administering a dose of glucocorticoid receptor antagonist (GRA) to a patient with Cushing's syndrome and an elevated ACTH level, wherein the amount of GRA administered to said patient is sufficient to increase ACTH from the pituitary gland by at least two-fold in persons with normal Hypothalamus Pituitary Adrenal (HPA) function; then, at least two hours following said administration, removing from the patient a venous sample from an inferior petrosal sinus and a venous sample from a peripheral vein, and determining the ACTH concentration ratio from the patient, wherein the ACTH concentration ratio is derived from the ACTH concentrations in fluid obtained from either the left or right inferior petrosal venous sinus and from fluid obtained from a periphery venous sample; and wherein an ACTH concentration ratio of greater than 3 for the ACTH concentration from the inferior venous sinus sample divided by the ACTH concentration from the periphery venous sinus sample is indicative of Cushing's disease.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.48485
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15236015', '15796443', '15627414', '15697878', '15915477']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.778010718665562
- 35 USC 102 Novelty (BERT): 0.697121962231854
- Combined Prediction Score: 0.7699218430221912
- Mean Citation Score: 512.1089400000002
- Max Citation Score: 713.4526
- Similarity Product: 706.217636544299

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test