PATENT CLAIM ANALYSIS

Application Number: 15886318
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["435", "135000"]

Abstract:
Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

Claim (Index 10):
The method of  claim 1 , wherein the mutant of BsteE esterase has a first mutation of T25H, a second mutation of L92H, and a third mutation selected from the group consisting of C115S, C115A, K121R, K121Y, K121H, K121D, K121L, K121T, K121A, K121N, E123T, M126F, M126V, M126I, M126Q, M126N, K164S, L166N, L166M, L166I, L166T, L166A, I170N, I170Q, I170V, I170T, I170A, D172N, M194A, M194L, I195G, I195A, I195V, and K215N.

Metadata:
- Claim Count in Document: 52.0
- Percentile: 88.0
- Lexical Diversity: 1.68085
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15010557', '14802372', '15789133', '15841828', '15182698']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6239814390352811
- 35 USC 102 Novelty (BERT): 0.4823352613421136
- Combined Prediction Score: 0.6098168212659645
- Mean Citation Score: 107.54121779999998
- Max Citation Score: 121.727425
- Similarity Product: 74.35092593626081

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test