PATENT CLAIM ANALYSIS

Application Number: 15920446
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-09
Patent Classification: ["435", "006100"]

Abstract:
The present invention relates to methods of depleting or isolating target RNA from a nucleic acid sample.

Claim (Index 17):
A method of depleting or isolating target RNA from a nucleic acid sample comprising target and non-target RNA molecules, comprising:\n (a) contacting the nucleic acid sample with reverse transcriptase, dNTPs, at least one modified dNTP, and at least one DNA primer complementary to part of the target RNA, and reverse transcribing the target RNA to form a modified DNA-RNA hybrid, thereby generating a treated sample, wherein the at least one DNA primer specifically hybridizes to the target RNA, the at least one modified dNTP is dNTP with affinitive moiety or dNTP with reactive moiety; and (b) contacting the treated sample with a matrix that specifically interacts with the modified dNTPs on the modified DNA-RNA hybrid, such that the modified DNA-RNA hybrid bind to the matrix and are removed from the treated sample,\n wherein the modified dNTPs are dNTPs with affinitive moiety and the matrix is affinitive matrix, or the modified dNTPs are dNTPs with reactive moiety and the matrix is reactive matrix.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 90.0
- Lexical Diversity: 1.0
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12940981', '14223788', '14644455', '15688600', '14390012']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.595057269856201
- 35 USC 102 Novelty (BERT): 0.5257306182406742
- Combined Prediction Score: 0.5881246046946483
- Mean Citation Score: 333.703962
- Max Citation Score: 361.99994
- Similarity Product: 324.3385785874152

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test