PATENT CLAIM ANALYSIS

Application Number: 15994947
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "210200"]

Abstract:
This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.

Claim (Index 1):
A method for the treatment of cancer, which method comprises administering to a patient a compound of the formula (0): or a salt, N-oxide or tautomer thereof, wherein: T 1  is selected from N and CH; T 2  is selected from N, CH and CF; R 1  is selected from hydrogen, fluorine, C 1-4  hydrocarbyl and C 1-4  hydrocarbyloxy; R 2  is selected from hydrogen, fluorine, C 1-4  hydrocarbyl and C 1-4  hydrocarbyloxy; R 3  is selected from hydrogen, methyl, fluorine, chlorine and bromine; one of M 1  and M 2  is a group R 4  selected from hydrogen, methyl, fluorine, chlorine and bromine; and the other of M 1  and M 2  is a moiety -A-R 7 ; R 5  is selected from hydrogen, cyano, C 1-3  alkyl, cyclopropyl, chlorine, carboxy, and C 1-3 -alkoxy-carbonyl; R 6  is selected from hydrogen, fluorine, C 1-4  alkyl; and C 1-4  alkoxy optionally substituted with NR d R e  where R d  and R e  are the same or different and each is selected from hydrogen and C 1-4  alkyl, or NR d R e  forms a 4 to 7 membered saturated heterocyclic ring optionally containing a second heteroatom ring member selected from N, O and S and oxidized forms of S, the saturated heterocyclic ring being optionally substituted with one or more substituents selected from oxo, methyl, hydroxy and fluorine; A is selected from:\n (i) a bond; \n (ii) (CR p R q ) x  where R p  and R q  are each independently hydrogen or methyl and x is 1 to 4; \n (iii) an oxygen atom; \n (iv) a group NR r  wherein R r  is hydrogen or methyl; and \n (v) a saturated chain of 2 to 10 chain members in length containing at least one carbon atom chain member, at least one heteroatom chain member selected from nitrogen and oxygen, and optionally one or more further carbon atom chain members and/or heteroatom chain members selected from nitrogen, oxygen, sulphur, sulphinyl and sulphonyl; the saturated chain being optionally substituted with one or more substituents selected from \u2550O, C 1-4  hydrocarbyl, fluoro-C 1-4  hydrocarbyl, hydroxy-C 1-4  hydrocarbyl, C 1-2 -alkoxy-C 1-4  hydrocarbyl, and fluorine wherein two hydrocarbyl substituents on the same carbon atom may optionally link to form a ring of three to five ring members; \n R 7  is selected from hydrogen; R 11 SO 2 \u2014; amino; NH-Hyd 1 ; N(Hyd 1 ) 2 ; and a group Cyc 1  wherein Cyc 2  is a carbocyclic or heterocyclic aromatic or non-aromatic group of 3 to 10 ring members of which 0 to 3 are selected from O, N and S and oxidised forms thereof, the carbocyclic or heterocyclic aromatic or non-aromatic group being optionally substituted with one or more substituents R 8 ; provided that when A is a bond, (CR p R q ) x , an oxygen atom or NR r , then R 7  is other than hydrogen; and provided also that when R 7  is hydrogen, then A has a chain length of at least four chain members and contains at least two heteroatom chain members; R 8  is selected from:\n halogen; \n oxo; \n cyano; \n nitro; \n a carbocyclic or heterocyclic group having from 3 to 12 ring members, of which 0, 1, 2, 3 or 4 are heteroatom ring members selected from O, N and S and oxidised forms thereof, the carbocyclic or heterocyclic group being optionally substituted with one or more substituents R 9 ; and \n a group R a -R b ; \n R a  is a bond, O, CO, X 1 C(X 2 ), C(X 2 )X 1 , X 1 C(X 2 )X 1 , S, SO, SO 2 , NR c , SO 2 NR c  or NR c SO 2 ; R b  is:\n hydrogen; \n a carbocyclic and heterocyclic group having from 3 to 12 ring members, of which 0, 1, 2, 3 or 4 are heteroatom ring members selected from O, N and S and oxidised forms thereof, the carbocyclic or heterocyclic group being optionally substituted with one or more substituents R 9 ; \n an acyclic C 1-12  hydrocarbyl group optionally substituted with one or more substituents selected from hydroxy; oxo; halogen; cyano; nitro; carboxy; amino; mono- or di-C 1-8  non-aromatic hydrocarbylamino; and carbocyclic and heterocyclic groups having from 3 to 12 ring members, of which 0, 1, 2, 3 or 4 are heteroatom ring members selected from O, N and S and oxidised forms thereof, the carbocyclic or heterocyclic group being optionally substituted with one or more substituents R 9 ; wherein one or more but not all of the carbon atoms of the acyclic C 1-12  hydrocarbyl group may optionally be replaced by O, S, SO, SO 2 , NR c , X 1 C(X 2 ), C(X 2 )X 1  or X 1 C(X 2 )X 1 ; \n R c  is:\n hydrogen; \n a carbocyclic and heterocyclic group having from 3 to 12 ring members, of which 0, 1, 2, 3 or 4 are heteroatom ring members selected from O, N and S and oxidised forms thereof, the carbocyclic or heterocyclic group being optionally substituted with one or more substituents R 9 ; \n an acyclic C 1-12  hydrocarbyl group optionally substituted with one or more substituents selected from hydroxy; oxo; halogen; cyano; nitro; carboxy; amino; mono- or di-C 1-8  non-aromatic hydrocarbylamino; and carbocyclic and heterocyclic groups having from 3 to 12 ring members, of which 0, 1, 2, 3 or 4 are heteroatom ring members selected from O, N and S and oxidised forms thereof, the carbocyclic or heterocyclic group being optionally substituted with one or more substituents R 9 ; wherein one or more but not all of the carbon atoms of the acyclic C 1-12  hydrocarbyl group may optionally be replaced by O, S, SO, SO 2 , NH, N\u2014C 1-4  alkyl, C(O)O, OC(O), NH(CO), C(O)NH, NH(CO)NH, N(C 1-4  alkyl)C(O), C(O)N(C 1-4  alkyl) \n X 1  is O, S or NR c ; and X 2  is \u2550O, \u2550S or \u2550NR c ; wherein R 9  is selected from R 8  provided that when the substituents R 9  contain a carbocyclic or heterocyclic group, the said carbocyclic or heterocyclic group is unsubstituted or substituted with one or more substituents R 10 ; R 10  is selected from halogen, oxo, cyano, and an acyclic C 1-6  hydrocarbyl group optionally substituted with one or more substituents selected from hydroxy; oxo; halogen; cyano; carboxy; amino; mono- or di-C 1-2  alkylamino; wherein one but not all of the carbon atoms of the acyclic C 1-6  hydrocarbyl group may optionally be replaced by O, S, SO, SO 2 , NH or NMe; R 11  is selected from amino, Hyd 1 , NH-Hyd 1 , N(Hyd 1 ) 2 ; and Cyc 1 ; Hyd 1  is a non-aromatic C 1-6  hydrocarbyl group optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, amino and Cyc 1 , wherein one or two of the carbon atoms of the non-aromatic C 1-6  hydrocarbyl group may optionally be replaced by O, NH, N-Hyd 2 , C(\u2550O), S, SO or SO 2 , provided that at least one carbon atom of the hydrocarbyl group remains; Hyd 2  is a C 1-4  hydrocarbyl group; and wherein in any group consisting of or containing a hydrocarbyl moiety, the hydrocarbyl moiety is a hydrocarbon group optionally containing one or more single, double or triple carbon-carbon bonds or combinations thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.29167
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15118072', '15764960', '11993831', '10564166', '12877499']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8461333175675325
- 35 USC 102 Novelty (BERT): 0.5660426241011822
- Combined Prediction Score: 0.8181242482208975
- Mean Citation Score: 392.32361
- Max Citation Score: 478.39017
- Similarity Product: 367.9213019227696

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test