PATENT CLAIM ANALYSIS

Application Number: 16005131
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["435", "006100"]

Abstract:
The present invention relates to a method for producing RNA. In particular, the present invention relates to a method for producing RNA, which is scalable and provides RNA at a high purity. The present invention provides a method for producing RNA under GMP and/or cGMP-compliant conditions. The invention further provides specific processes for use as a quality control in the manufacturing of a template DNA and/or in a method for producing RNA, in particular by in vitro transcription.

Claim (Index 1):
A method for producing purified RNA comprising the following steps:\n a) providing a template DNA comprising a nucleic acid sequence encoding an RNA sequence, wherein the following steps are used to control the quality of the template DNA provided in step a):\n I) determining the concentration of the template DNA in a sample; \n II) determining the integrity of the template DNA; \n III) determining the identity of the template DNA; and \n IV) determining the purity of the template DNA; \n and b) in vitro transcription of the template DNA in order to obtain a composition comprising the RNA; and c) purifying the RNA by at least one purification step selected from the group consisting of a precipitation step and a chromatographic step to obtain purified RNA, wherein the following steps are used to assess the quality of the RNA obtained in step b or the purified RNA obtained in step c:\n i) determining the concentration of the RNA or the purified RNA in a sample; \n ii) determining the integrity of the RNA or the purified RNA; \n iii) determining the identity of the RNA or the purified RNA; \n iv) determining the purity of the RNA or the purified RNA; \n v) determining the pH of a sample comprising the RNA or the purified RNA; \n vi) determining the osmolality of a sample comprising the RNA or the purified RNA; \n vii) determining the presence and/or the amount of the template DNA in a sample comprising the RNA or the purified RNA; and \n viii) determining the presence and/or the amount of an organic solvent in a sample comprising the RNA or the purified RNA.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 1.97674
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15044094', '15743988', '10764581', '12087951', '13921989']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.54958055952875
- 35 USC 102 Novelty (BERT): 0.6772253903429352
- Combined Prediction Score: 0.5623450426101685
- Mean Citation Score: 388.201716
- Max Citation Score: 701.8840299999997
- Similarity Product: 650.6579490443817

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test