PATENT CLAIM ANALYSIS

Application Number: 15896400
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["552", "553000"]

Abstract:
The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, prodrugs and esters thereof, The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.

Claim (Index 1):
A compound represented by Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: is Each R a , and R b  is independently selected from the group consisting of:\n 1) Hydrogen, \n 2) Optionally substituted \u2014C 1 -C 8  alkyl, \n 3) Optionally substituted \u2014C 2 -C 8  alkenyl, \n 4) Optionally substituted \u2014C 2 -C 8  alkynyl, \n 5) Optionally substituted \u2014C 3 -C 8  cycloalkyl, \n 6) Optionally substituted aryl, \n 7) Optionally substituted arylalkyl, \n 8) Optionally substituted 3- to 8-membered heterocycloalkyl, \n 9) Optionally substituted heteroaryl, and \n 10) Optionally substituted heteroarylalkyl; \n R b1 , R b2 , R b3 , and R b4  are independently selected from hydrogen, halogen or optionally substituted \u2014C 1 -C 8  alkyl; m is selected from 1, 2 or 3; X, Y and Z are independently selected from CR b1  and N, wherein R b1  is previously defined; R 1  is optionally substituted C 1 -C 6  alkyl, hydrogen, hydroxyl, \u2014OSO 3 H, \u2014OSO 3 \u2212 , \u2014OAc, \u2014OPO 3 H 2  or \u2014OPO 3 2\u2212 ; R 2  is optionally substituted C 1 -C 6  alkyl, hydrogen, halogen, CN, N 3 , hydroxyl, \u2014OSO 3 H, \u2014OSO 3 \u2212 , \u2014OAc, \u2014OPO 3 H 2 , \u2014OPO 3 2\u2212 , \u2014SR a  or \u2014NHR a , wherein R a  is previously defined; alternatively, R 1  and R 2  are taken together with the carbon atoms to which they attached to form \u2014CH\u2550CH\u2014 or cycloalkyl ring or heterocycloalkyl ring such as, but not limited to cyclopropyl, or epoxide; R 3a  and R 3b  are independently selected from hydrogen, hydroxyl, optionally substituted C 1 -C 6  alkyl, or optionally substituted \u2014O\u2014C 1 -C 6  alkyl; alternatively, R 3a  and R 3b  are taken together with the carbon atom to which they attached to form \u2014C(O); and R 4  is selected from the group consisting of:\n 1) Hydrogen, \n 2) Halogen, \n 3) Optionally substituted \u2014C 1 -C 8  alkyl, \n 4) Optionally substituted \u2014C 2 -C 8  alkenyl, \n 5) Optionally substituted \u2014C 2 -C 8  alkynyl, and \n 6) Optionally substituted \u2014C 3 -C 8  cycloalkyl; \n provided that the compound of Formula I is not

Metadata:
- Claim Count in Document: 13.0
- Percentile: 88.0
- Lexical Diversity: 1.29412
- Patent Class: 552.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15724919', '15793554', '15597423', '15597431', '15439303']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7514186760370443
- 35 USC 102 Novelty (BERT): 0.5903904969597109
- Combined Prediction Score: 0.7353158581293109
- Mean Citation Score: 318.1284100000001
- Max Citation Score: 336.9179
- Similarity Product: 271.1319172414124

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test