PATENT CLAIM ANALYSIS

Application Number: 15916271
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-01
Patent Classification: ["435", "006100"]

Abstract:
The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of a nucleic acid.

Claim (Index 1):
An engineered, non-naturally occurring Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated (Cas) system comprising:\n an RNA guide or a nucleic acid encoding the RNA guide, wherein the RNA guide comprises a direct repeat sequence and a spacer sequence capable of hybridizing to a target nucleic acid, wherein the direct repeat sequence comprises 5\u2032-X 1 X 2 X 3 X 4 TX 5 TX6AAAC-3\u2032 (SEQ ID NO: 151) at the 3\u2032 terminal end of the RNA guide, and wherein X 1  is A or C or G, X 2  is G or T, X 3  is A or G, X 4  is C or G or T, X 5  is C or T, and X 6  is A or G; and a Type VI-D CRISPR-Cas effector protein or a nucleic acid encoding the effector protein, wherein the effector protein is capable of binding to the RNA guide and of targeting the target nucleic acid sequence complementary to the spacer sequence, and wherein the target nucleic acid is an RNA.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.59259
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15467922', '15897089', '15783770', '15507176', '13842859']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.2855645456340912
- 35 USC 102 Novelty (BERT): 0.5476315424409158
- Combined Prediction Score: 0.3117712453147737
- Mean Citation Score: 379.938508
- Max Citation Score: 389.89246
- Similarity Product: 300.77930140878203

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test