PATENT CLAIM ANALYSIS

Application Number: 16158074
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["435", "007800"]

Abstract:
Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy), e.g., amyotrophic lateral sclerosis (ALS), etc.

Claim (Index 1):
A method of detecting the presence of occluded amino acids in a protein of interest in a test sample, said method comprising:\n a. subjecting the test sample to a reaction adapted to covalently modify label-able amino acids with a first reactive moiety conjugated to a first detectable label; b. subjecting the sample to denaturing conditions; c. subjecting the test sample to a reaction adapted to covalently modify label-able amino acids with a first reactive moiety conjugated to a second detectable label or a second reactive moiety conjugated to a second detectable label, wherein the first detectable label and second detectable label are visually distinct; and d. making visible the first detectable label and second detectable label; wherein the presence of the second detectable label in addition to the first detectable label is indicative of the presence of occluded label-able amino acids in the protein of interest in the test sample.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 97.0
- Lexical Diversity: 2.24615
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13638237', '13056877', '12030024', '14482899', '12154664']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5966761429540014
- 35 USC 102 Novelty (BERT): 0.4881341888964461
- Combined Prediction Score: 0.5858219475482459
- Mean Citation Score: 212.087584
- Max Citation Score: 243.99301
- Similarity Product: 191.06095174023628

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test