PATENT CLAIM ANALYSIS

Application Number: 15757716
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-02
Patent Classification: ["546", "329000"]

Abstract:
The present invention includes novel compositions inhibiting CYP3A4. The present invention further includes a novel method of inhibiting CYP3A4 in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the invention. In one embodiment, the subject is further administered at least one additional therapeutic agent.

Claim (Index 12):
A method of inhibiting CYP3A4 in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a composition comprising at least one compound of Formula (I): wherein in Formula (I): R 1  and R 2  are each independently selected from the group consisting of H, C 1 -C 6  alkyl, substituted C 1 -C 6  alkyl, aryl, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, -(C 1 -C 6 )alkyl-aryl, substituted -(C 1 -C 6 )alkyl-aryl,-(C 1 -C 6 )alkyl-phenyl, substituted -(C 1 -C 6 )alkyl-phenyl, -(C 1 -C 6 )alkyl-carbocyclic, -(C 1 -C 6 )alkyl-heteroaryl, substitued -(C 1 -C 6 )alkyl-heteroaryl, and N(R 4 )(R 5 ); R 3  is selected from the group consisting of H, -C 1 -C 6  alkyl, aryl, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, -(C 1 -C 6 )alkyl-aryl, substituted -(C 1 -C 6 )alkyl-aryl, -(C 1 -C 6 )alkyl-phenyl, substituted -(C 1 -C 6 )alkyl-phenyl, -(C 1 -C 6 )alkyl-carbocyclic, -(C 1 -C 6 )alkyl-heteroaryl, and substituted -(C 1 -C 6 )alkyl-heteroaryl and -C(\u2550O)R 6 , wherein the alkyl group is optionally substituted; R 4  and R 5  are each independently selected from the group consisting of H, C 1 -C 6  alkyl, substituted C 1 -C 6  alkyl, aryl, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, -(C 1 -C 6 )alkyl-aryl, substituted -(C 1 -C 6 )alkyl-aryl, -(C 1 -C 6 )alkyl-phenyl, substituted -(C 1 -C 6 )alkyl-phenyl, -(C 1 -C 6 )alkyl-carbocyclic, -(C 1 -C 6 )alkyl-heteroaryl, and substitued-(C 1 -C 6 )alkyl-heteroaryl; R 6  is selected from the group consisting of phenyl, substituted phenyl, -(C 1 -C 6 )alkyl-phenyl, substitued -(C 1 -C 6 ) alkyl-phenyl, -(C 1 -C 6 )alkyl-heteroaryl, substitued -(C 1 -C 6 )alkyl-heteroarly, and OR 7 ; R 7  is selected from the group consisting of H, -C 1 -C 6  alkyl, substituted C 1 -C 6  alkyl,aryl, cycloalkyl phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, -(C 1 -C 6 )alkyl-phenyl, substituted -(C 1 -C 6 )alkyl-aryl, substituted -(C 1 -C 6 )alkyl-aryl, -(C 1 -C 6 )alkyl-carbocyclic, -(C 1 -C 6 )alkyl-heteroaryl, substitued -(C 1 -C 6 )alkyl-heteroaryl; each occurrence of X is independently selected from the group consisting of CH 2 , NH, S, and O; m is an integer from 0 to 3; n is an integer from 0 to 3; and p is an integer from 0 to 1; a salt or solvate, and any combinations thereof

Metadata:
- Claim Count in Document: 42.0
- Percentile: 90.0
- Lexical Diversity: 1.66667
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14185861', '14625449', '15278561', '11174302', '15127305']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.767673797278412
- 35 USC 102 Novelty (BERT): 0.5109375259857664
- Combined Prediction Score: 0.7420001701491474
- Mean Citation Score: 264.24001400000003
- Max Citation Score: 271.54553
- Similarity Product: 165.33577299422143

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test