PATENT CLAIM ANALYSIS

Application Number: 16298762
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "293000"]

Abstract:
A novel class of fluorinated derivatives of Formula I have been prepared and found to be useful in the treatment of cancers and other disorders related mediated by Bromodomain-Containing Proteins.

Claim (Index 1):
A compound of Formula I or a pharmaceutically acceptable salt, solvate and/or prodrug thereof: wherein: R 1  is selected from H, optionally substituted C 1-20 alkyl, optionally substituted C 2-20 alkenyl, optionally substituted C 3-20 cycloalkyl, optionally substituted C 6-20 aryl, optionally substituted heterocycloalkyl, optionally substituted heteroaryl, optionally substituted C 1-6 alkyleneC 3-10 cycloalkyl, optionally substituted C 1-6 alkylenearyl, optionally substituted C 1-6 alkyleneheterocycloalkyl, optionally substituted C 1-6 alkyleneheteroaryl, OR 6 , CN, COOR 6 , CONR 6 R 7 , C 1-6 alkyleneOR 6 , C 1-6 alkyleneCOOR 6 , NR 6 R 7 , C 1-6 alkyleneNR 6 R 7 , C 1-6 alkyleneCONR 6 R 7 , C 1-6 alkyleneNCOR 6 , C 1-6 alkyleneCSNR 6 R 7  SR 6 , C 1-6 alkyleneSR 6 , SOR 6 , C 1-6 alkyleneSOR 6 , SO 2 R 6  and C 1-6 alkyleneSOR 6 ; R 2  and R 3  are independently selected from H, fluoro, and C 1-6 alkyl, C 1-6 alkylOR 6 , C 1-6 alkylCOOR 6 , C 1-6 alkylCONR 6 R 7 , C 1-6 alkylSR 6 , C 1-6 alkylSOR 6 , C 1-6 alkylSO 2 R 6 , C 1-6 alkylNR 6 R 7 , C 1-6 alkylNCOR 6  or R 2  and R 3  together form an oxo (\u2550O) group, or R 2  and R 3 , together with the carbon atom to which they are attached, form C 3-7 cycloalkyl or C 3-7 heterocycloalkyl; R 4  is selected from H, optionally substituted C 1-20 alkyl, optionally substituted C 2-20 alkenyl, optionally substituted C 3-20 cycloalkyl, optionally substituted C 6-20 aryl, optionally substituted heterocycloalkyl, optionally substituted heteroaryl, optionally substituted C 1-6 alkyleneC 3-10 cycloalkyl, optionally substituted C 1-6 alkylenearyl, optionally substituted C 1-6 alkyleneheterocycloalkyl, optionally substituted C 1-6 alkyleneheteroaryl, OR 6 , CN, COOH, COOR 6 , COONH 2 , COONR 6 R 7 , C 1-6 alkyleneOR 6 , NR 6 R 7 , C 1-6 alkyleneNR 6 R 7  C 1-6 alkyleneCONR 6 R 7 , SR 6 , CN, C 1-6 alkyleneOR 6 , NR 6 R 7 , C 1-6 alkyleneNCOR 6  and halogen; R 5  is selected from H, optionally substituted monocyclic rings having 0-3 heteroatoms independently selected from N, O and S and the optional substituents are selected from 1 to 3 C 1-6 alkyl and C 1-6 alkoxy, optionally substituted C 1-20 alkyl, optionally substituted C 2-20 alkenyl, optionally substituted C 3-20 cycloalkyl, optionally substituted C 6-20 aryl, optionally substituted heterocycloalkyl, optionally substituted heteroaryl, optionally substituted C 1-6 alkyleneC 3-10 cycloalkyl, optionally substituted C 1-6 alkylenearyl, optionally substituted C 1-6 alkyleneheterocycloalkyl, optionally substituted C 1-6 alkyleneheteroaryl, OR 6 , \u2014CN, COOR 6 , CONR 6 R 7 , C 1-6 alkyleneOR 6 , C 1-6 alkyleneCOOR 6 , NR 6 R 7  and C 1-6 alkyleneNR 6 R 7 , C 1-6 alkyleneCONR 6 R 7 , C 1-6 alkyleneNCOR 6  C 1-6 alkyleneCSNR 6 R 7  SR 6 , C 1-6 alkyleneSR 6 , SOR 6 , C 1-6 alkyleneSOR 6 , SO 2 R 6 , C 1-6 alkyleneSO 2 R 6 ; R 6  and R 7  are each independently selected from H, C 1-6 alkyl, C 3-10 cycloalkyl, heterocycloalkyl and haloC 1-6 alkyl; A is selected from C 0-6 alkylene, O, S, SO, SO 2  and NR 6 ; X 1 , X 2  and X 3  are the same or different and are selected from H, halogen, and C 1-6 alkyl, provided that at least one of X 1 , X 2  and X 3  is F; and one or more of the atoms in the compounds of Formula I are optionally replaced with a radioactive isotope thereof.

Metadata:
- Claim Count in Document: 28.0
- Percentile: 99.0
- Lexical Diversity: 1.10714
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15546324', '15619671', '15749950', '14204076', '15150492']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8140167611061135
- 35 USC 102 Novelty (BERT): 0.5463963513604008
- Combined Prediction Score: 0.7872547201315423
- Mean Citation Score: 341.494826
- Max Citation Score: 400.17456
- Similarity Product: 336.2552669606781

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test