PATENT CLAIM ANALYSIS

Application Number: 15865847
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-02
Patent Classification: ["514", "507000"]

Abstract:
The present invention relates to the treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC), which involves administering multiple boluses of the diastereomerically pure folate adjuvant [6R]-5,10-methylenetetrahydrofolate in 5-fluorouracil (5-FU) based chemotherapy.

Claim (Index 1):
A method of treating a human diagnosed with a solid tumor, which method comprises:\n a) on Day 1, administering an IV bolus containing 10-1000 mg/m 2  5 fluorouracil (5-FU) or a fluorinated pyrimidine base, followed, either simultaneously or after a period of 10 min-4 hours, by b) administering two or more IV boluses, interspaced by a period of 10-60 minutes, each containing 5-1000 mg/m 2  [6R]-5,10-methylenetetrahydrofolate (6R-MTHF) on Day 1, followed by c) administering a continuous infusion of 5-FU or a fluorinated pyrimidine base over a period of 46 hours, or until the end of Day 2, followed by d) optionally administering one IV bolus containing 5-1000 mg/m 2  6R-MTHF before the end of Day 1, followed by e) on Day 2, optionally administering one or more IV boluses each containing 5-1000 mg/m 2  6R-MTHF, wherein step (b) is optionally repeated up to 4 times on Day 1 with an interval of 10 min-4 hours between each repetition, and wherein step (e) is optionally repeated up to 4 times on Day 2 with an interval of between 10 min-60 min between each bolus being administered, and wherein all steps (a)-(e) are optionally repeated every 2 weeks for up to eight (8) cycles.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 86.0
- Lexical Diversity: 1.17949
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15114690', '14372701', '12805287', '14811905', '13002758']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7469990520512528
- 35 USC 102 Novelty (BERT): 0.5329661444554464
- Combined Prediction Score: 0.7255957612916722
- Mean Citation Score: 265.23253
- Max Citation Score: 315.36057
- Similarity Product: 191.51288626244187

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test