PATENT CLAIM ANALYSIS

Application Number: 15903503
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "006400"]

Abstract:
What is described is a method for treating cancer in a patient in need of such treatment through the use of an antagonist to CXCR1 and/or CXCR2 receptors by administering a therapeutically effective amount of an antagonist of CXCR1 and/or CXCR2, or pharmaceutical compositions thereof, either alone as monotherapy, or in combination with at least one other anticancer therapy.

Claim (Index 1):
A method of treating cancer in a patient in need of such treatment, comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I wherein R 1  and R 2  are independently selected from the group consisting of hydrogen, 2- or 3- or 4-halo-phenyl, heteroalkyl, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; wherein R 3  is selected from \u2014B(R 4 R 5 ), \u2014R 6 \u2014B(R 4 R 5 ), R 6 , \u2014C(O)\u2014R 6 , \u2014O\u2014R 6 , \u2014S(O) y \u2014R 6  (wherein y=0, 1, or 2), \u2014P(O)\u2014(R 4 R 5 ) and \u2014N(R 7 R 8 ); wherein R 4  and R 5  are independently hydrogen, hydroxyl, aryloxy, or alkoxy, or wherein R 4  and R 5  together form a cyclic ester, or an acid anhydride (either mixed or symmetrical); wherein R 6  is selected from alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl; wherein R 7  and R 8  are independently selected from hydrogen, alkyl, haloalkyl, aryl, cycloalkyl, arylalkyl, heteroalkyl, heterocyclyl and heterocyclylalkyl; R 7  and R 8  are both oxygen to form a nitro group; or R 7  and R 8  together with the nitrogen to which they are attached, form a heterocyclyl; and wherein R 9  is selected from the group consisting of hydrogen, heteroalkyl, alkyl, aminoalkyl, aryl, arylalkyl, carboxyalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl; or \u2014B(R 4 R 5 ), \u2014BF 3 \u2212 M + , \u2014R 6 \u2014B(R 4 R 5 ), \u2014R 6 \u2014BF 3 \u2212 M + , R 6 , \u2014C(O)\u2014R 6 , \u2014O\u2014R 6 , \u2014S(O) y \u2014R 6  (wherein y=0, 1, or 2), \u2014P(O)\u2014(R 4 R 5 ) and \u2014N(R 7 R 8 ); or an ionizing group selected from the group consisting of carboxylates, amines, phosphonates, and phosphates; wherein X 1  is carbon or nitrogen; X 2  is \u2014S(O) y \u2014 (wherein y=0, 1, or 2), \u2014N(R 9 )\u2014, or oxygen; and wherein n is an integer between 0 and 8; or a pharmaceutically suitable solvate or salt thereof.

Metadata:
- Claim Count in Document: 49.0
- Percentile: 88.0
- Lexical Diversity: 1.34043
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15354936', '15627766', '13957665', '15279361', '14610960']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7699635415398367
- 35 USC 102 Novelty (BERT): 0.5727930308667842
- Combined Prediction Score: 0.7502464904725314
- Mean Citation Score: 342.598746
- Max Citation Score: 541.30383
- Similarity Product: 350.05926432632083

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test