PATENT CLAIM ANALYSIS

Application Number: 16016101
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["435", "325000"]

Abstract:
A 3D decellularized bone scaffold seeded with cancer cells, such as prostate cancer cells or Ewing's sarcoma is provided. The three-dimensional includes Ewing's sarcoma (ES) tumor cells; and an engineered human bone scaffold. The engineered human bone scaffold further includes osteoblasts that secrete substance of the human bone, and osteoclasts that absorb bone tissue during growth and healing. The engineered human bone scaffold includes the tissue engineered three-dimensional model which recapitulates the osteolytic process. The engineered human bone scaffold is engineered by co-culturing of osteoblasts and osteoclasts. The osteoblast is produced by cell differentiation process from mesenchymal stem cells. The osteoclast is produced by cell differentiation from human monocytes, wherein the human monocytes are isolated from buffy coats. The scaffold can be used with cancer cell lines to identify therapeutic targets to slow, stop, and reverse tumor growth and progression as well as to predict the efficacy of potential therapeutics.

Claim (Index 3):
The three-dimensional model of  claim 1 , wherein the osteoblast is produced by cell differentiation process from mesenchymal stem cells.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 2.0241
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14105599', '14678392', '14942543', '15585653', '13827170']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5605937906427799
- 35 USC 102 Novelty (BERT): 0.5208329778298728
- Combined Prediction Score: 0.5566177093614892
- Mean Citation Score: 262.66348200000004
- Max Citation Score: 303.0057700000001
- Similarity Product: 218.9523977693797

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test