PATENT CLAIM ANALYSIS

Application Number: 15933800
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["530", "391900"]

Abstract:
The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is derived from o-hydroxy p-amino benzylic alcohol, wherein the peptide chain is connected to the phenyl ring via the p-amino group, the drug is connected to the phenyl ring via the benzylic alcohol moiety, and the protein is connected to the phenyl ring via the o-hydroxy group; further to a process for the preparation of said protein-drug-conjugates via various intermediates, to the pharmaceutical use of such protein drug conjugates, such as methods of controlling the growth of undesirable cells, to pharmaceutical compositions comprising such protein drug conjugates, and to intermediates of the preparation of the protein drug conjugates.

Claim (Index 18):
A compound of formula (VI): wherein AA 1  represents one alpha amino acid structure in which carboxyl terminal is amide bonded to NH; (3) denotes the alpha amino group of said alpha amino acid structure, R1 and R2 are identical or different and independently from each other selected from the group consisting of hydrogen and PGN; PGN is a protecting group selected from the group consisting of Boc, Fmoc and benzyloxycarbonyl; and AA 1  is selected from the group consisting of alanine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophan, lysine, lysine with side chain amino group protected with acetyl or formyl groups, arginine, histidine, ornithine, omithine with side chain amino group protected with acetyl or formyl groups, and citrulline.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 2.50847
- Patent Class: 530.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14001237', '14110596', '14655357', '13355030', '15312614']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6861074748081923
- 35 USC 102 Novelty (BERT): 0.5328609416822979
- Combined Prediction Score: 0.670782821495603
- Mean Citation Score: 218.73406400000005
- Max Citation Score: 366.81186
- Similarity Product: 265.9956277505994

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test