PATENT CLAIM ANALYSIS

Application Number: 16266782
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "278000"]

Abstract:
The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R 1  to R 5  are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.

Claim (Index 21):
The compound of formula (I) according to  claim 1  which compound is selected from the group consisting of:\n 2-[1-(4-Fluorophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide; \n 2-[1-(3-Fluorophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide; \n 2-[1-(2-Fluorophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide; \n 2-(4-Oxo-1-phenyl-8-(1H-pyrazolo [3,4-b] pyridine -5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2,2,2-trifluoroethyl)acetamide; \n 2-(4-Oxo-1-phenyl-8-(1H-pyrazolo [3,4-b] pyridine -5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl)-N-phenylacetamide; \n N-Methyl-2-(4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine -5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2,2,2-trifluoroethyl)acetamide; \n N-(Adamantan-1-yl)-2-(4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl)acetamide; \n (RS)-3-(2-Oxo-1-phenylpyrrolidin-3-yl)-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one; \n 2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-propan-2-yl-N-(2,2,2-trifluoroethyl)acetamide; \n N,N-Dimethyl-2-[4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide; \n 1-Phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(trifluoromethyl)phenyl]-1,3,8-triazaspiro[4.5]decan-4-one; \n 3-[2-Fluoro-4-(trifluoromethyl)phenyl]-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one; \n 3-(2-Fluoro-4-methylphenyl)-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one; \n 4-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]benzonitrile; \n 3-(3-Chlorophenyl)-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one; \n 3-(4-Chloro-2-fluorophenyl)-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one; \n 3-(5-Chloro-2-fluoro-4-methyl-phenyl)-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one; \n N-(2-fluoroethyl)-2-[4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide; \n N-(2,2-difluoroethyl)-2-[4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide; \n 2-(1-(3-Chlorophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2,2,2-trifluoroethyl)acetamide; \n N-[2-(dimethylamino)ethyl]-2-[4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide; \n N-[2-(dimethylamino)ethyl]-2-[4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide; \n N-(1-hydroxy-2-methylpropan-2-yl)-2-[4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide; \n 2-[1-(3-Bromophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide; \n 2-[4-Oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1-[3-(trifluoromethyl)phenyl]-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide; \n 2-[1-(3-Chloro-5-fluorophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide; \n 2-[1-(3-Cyanophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide; or, \n a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 54.0
- Percentile: 99.0
- Lexical Diversity: 1.25
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15850826', '16057436', '15300762', '13822840', '11524978']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8047415293500119
- 35 USC 102 Novelty (BERT): 0.6632463044437646
- Combined Prediction Score: 0.7905920068593871
- Mean Citation Score: 435.21528
- Max Citation Score: 646.1227
- Similarity Product: 621.3553029779314

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test