PATENT CLAIM ANALYSIS

Application Number: 16267274
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-08
Patent Classification: ["514", "267000"]

Abstract:
The invention provides a compound of formula (I), (II) or (III): wherein R 1 , R 2 , R 3 , R 4  and R 5  have any of the values described in the specification, as well as compositions comprising a compound of formula (I), (II) or (III). The compounds and compositions are useful as chemotherapeutic sensitizing agents.

Claim (Index 1):
A compound of formula (I), (II) or (III): wherein:\n R 1  is phenyl, benzyl or (C 1 -C 3 )alkyl optionally substituted with halo, wherein the phenyl or benzyl is optionally substituted with one or more groups R x  that are independently selected from the group consisting of halo, carboxy, (C 1 -C 6 )alkoxycarbonyl, halo(C 1 -C 6 )alkoxycarbonyl, \u2014C(\u2550O)NR b R c , \u2014NHP(\u2550O)(OR d )(OR e ), \u2014NHC(\u2550O)OR f , \u2014B(OR g )(OR h ), \u2014S(O) 2 F, \u2014P(\u2550O)(F)(OR k ), \n and (C 1 -C 3 )alkyl substituted with halo, (C 1 -C 6 )alkoxycarbonyl, halo(C 1 -C 6 )alkoxycarbonyl, \u2014C(\u2550O)NR b R c , \u2014NHP(\u2550O)(OR d )(OR e ), \u2014NHC(\u2550O)OR f , \u2014B(OR g )(OR h ), \u2014S(O) 2 F, or \u2014P(\u2550O)(F)(OR k );\n R b  and R c  are each independently H or (C 1 -C 6 )alkyl; \n R d  and R e  are each independently H, (C 1 -C 6 )alkyl, or phenyl; \n R f  is H, (C 1 -C 6 )alkyl, or phenyl; \n R g  and R h  are each independently H or (C 1 -C 6 )alkyl, or R g  and R h  taken together with the boron to which they are attached form a 5- or 6-membered ring that is optionally substituted with one or more groups independently selected from (C 1 -C 6 )alkyl; \n R k  is (C 1 -C 6 )alkyl; and \n R mn  is H, (C 1 -C 6 )alkyl, or phenyl; \n R 2  and R 3  are each independently selected from H, halo or (C 1 -C 6 )alkyl that is optionally substituted with halo; \n R 4  is phenyl, wherein the phenyl is optionally substituted with one or more groups R xx  that are independently selected from the group consisting of halo, carboxy, \u2014OH, \u2014OR l , (C 1 -C 6 )alkoxycarbonyl, halo(C 1 -C 6 )alkoxycarbonyl, \u2014C(\u2550O)NR m R n , \u2014NHP(\u2550O)(OR p )(OR q ), \u2014NHC(\u2550O)NR m R n , \u2014NHS(O) 2 R ss , \u2014B(OR t )(OR tt ), \u2014S(O) 2 F, \u2014P(\u2550O)(F)(OR v ), \n and (C 1 -C 3 )alkyl optionally substituted with halo, (C 1 -C 6 )alkoxycarbonyl, halo(C 1 -C 6 )alkoxycarbonyl, \u2014C(\u2550O)NR m R n , \u2014N\u2014P(\u2550O)(OR p )(OR q ), \u2014NHC(\u2550O)OR s , \u2014B(OR t )(OR tt ) \u2014S(O) 2 F, or \u2014P(\u2550O)(F)(OR v );\n R m  and R n  are each independently H or (C 1 -C 6 )alkyl; \n R p  and R q  are each independently H, (C 1 -C 6 )alkyl, or phenyl; \n R s  is H, (C 1 -C 6 )alkyl, or phenyl; \n R ss  is (C 1 -C 6 )alkyl, or phenyl; \n R t  and R tt  are each independently H or (C 1 -C 6 )alkyl, or R t  and R tt  taken together with the boron and oxygens to which they are attached form a 5- or 6-membered ring that is optionally substituted with one or more groups independently selected from (C 1 -C 6 )alkyl; \n R v  is (C 1 -C 6 )alkyl; and \n R 5  is (C 1 -C 6 )alkyl or phenyl, wherein the alkyl or phenyl is optionally substituted with one or more groups that are independently selected from the group consisting of halo, (C 1 -C 6 )alkoxycarbonyl, \u2014NHP(\u2550O)(OR w )(OR y ), \u2014C(\u2550O)NR z R aa , \u2014NHC(\u2550O)OR bb , carboxy, or (C 1 -C 3 )alkyl substituted with \u2014NHP(\u2550O)(OR w )(OR y ); \n R z  and R aa  are each independently H or (C 1 -C 6 )alkyl; \n R w  and R y  are each independently H, (C 1 -C 6 )alkyl, or phenyl; and \n R bb  is H, (C 1 -C 6 )alkyl, or phenyl; \n or a salt thereof.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 99.0
- Lexical Diversity: 1.85366
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15192728', '14352096', '12990306', '14477566', '14342269']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7940646695325775
- 35 USC 102 Novelty (BERT): 0.5228961130140292
- Combined Prediction Score: 0.7669478138807226
- Mean Citation Score: 311.87255
- Max Citation Score: 326.97763
- Similarity Product: 275.54681779052373

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test