PATENT CLAIM ANALYSIS

Application Number: 15754562
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["530", "300000"]

Abstract:
A connector of a helical coiled coil-type structure connecting a first and a second molecule, wherein the first molecule comprises a peptidic first alpha-helix and the second molecule comprises a peptidic second alpha-helix, which second alpha-helix is coiled to the first alpha-helix. The first alpha-helix comprises a C-terminal region consisting of a repeat of an amino acid motif a-x 1  and the C-terminal motif a-x 1 -x 2 , or an N-terminal region consisting of a repeat of an amino acid motif x 1 -a and the N-terminal motif x 2 -x 1 -a, where a is a motif sequence of 4-8 amino acids, x 1  is Lysin, and x 2  is an extension of the motif. The extension consists of 1-10 amino acids and does not comprise more than 4 consecutive amino acids incorporated in said motif a-x 1  or x 1 -a. In a multimeric protein, two polypeptide chains can be connected to each other by such connector.

Claim (Index 11):
A multimeric protein comprising at least two polypeptide chains connected to each other by the connector of  claim 1 , wherein a first polypeptide chain incorporates the first alpha-helix, and the second polypeptide chain incorporates the second alpha-helix; and wherein the first and second polypeptide chains are connected by the helical coiled-coil type structure of the first and second alpha-helices, preferably wherein the protein is selected from the group consisting of:\n a) a vaccine component comprising a vaccine antigen and an adjuvant; b) an antibody or antibody format wherein each of the two polypeptide chains incorporates at least one antibody domain; c) an antibody derivative comprising an antibody and a non-antibody component, wherein at least one polypeptide chain of the antibody is connected to another polypeptide chain incorporating the component, preferably wherein the component is any of an organic and inorganic molecule, in particular a label, tag, enzyme, receptor, ligand, toxin, lipid, carbohydrate, or nucleic acid; and d) an affinity material, wherein a receptor or ligand is connected to a carrier.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 88.0
- Lexical Diversity: 2.39437
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14892973', '14414337', '11628483', '16080738', '14735024']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6323153612991259
- 35 USC 102 Novelty (BERT): 0.5359356986581788
- Combined Prediction Score: 0.6226773950350312
- Mean Citation Score: 310.62773
- Max Citation Score: 384.76822
- Similarity Product: 300.4287404262722

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test