PATENT CLAIM ANALYSIS

Application Number: 15767364
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "210180"]

Abstract:
The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, O and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

Claim (Index 1):
A compound of Formula (I): or a stereoisomer, an enantiomer, a diastereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein: alk is C 1-6  alkyl substituted with 0-5 R e ; ring B is independently selected from: C 3-6  cycloalkyl, C 3-6  cycloalkenyl, aryl, bicyclic carbocyclyl, and 6-membered heteroaryl; R 1  is independently selected from: halogen, NO 2 , \u2014(CH 2 ) n OR b , (CH 2 ) n S(O) p R c , \u2014(CH 2 ) n C(\u2550O)R b , \u2014(CH 2 ) n NR a R a , \u2014(CH 2 ) n CN, \u2014(CH 2 ) n C(\u2550O)NR a R a , \u2014(CH 2 ) n NR a C(\u2550O)R b , \u2014(CH 2 ) n NR a C(\u2550O)NR a R a , \u2014(CH 2 ) n NR a C(\u2550O)OR b , \u2014(CH 2 ) n OC(\u2550O)NR a R a , \u2014(CH 2 ) n C(\u2550O)OR b , \u2014(CH 2 ) n S(O) p NR a R a , \u2014(CH 2 ) n NR a S(O) p NR a R a , \u2014(CH 2 ) n NR a S(O) p R c , C 1-4  alkyl substituted with 0-3 R e , \u2014(CH 2 ) n \u2014C 3-6  carbocyclyl substituted with 0-3 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-3 R e ; R 2  is independently selected from: C 1-5  alkyl substituted with 0-3 R e ; C 1-5  alkenyl substituted with 0-3 R e , aryl substituted with 0-3 R e , heterocyclyl substituted with 0-3 R e , and C 3-6  cycloalkyl substituted with 0-3 R e ; provided when R 2  is C 1-5  alkyl, the methylene unit except the one attached to the pyridine ring may be replaced by O, N, and S; R 3  and R 4  are independently selected from: H, C 1-5  alkyl substituted with 0-3 R 6 ; \u2014(CH 2 ) n \u2014C 3-6  carbocyclyl substituted with 0-3 R 6 , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-3 R 6 ; provided R 3  and R 4  are not both H; alternatively, R 3  and R 4  together with the nitrogen atom to which they are both attached form a heterocyclic ring or a spiro heterocyclic ring comprising carbon atoms and 0 to 4 heteroatoms selected from N, NR a , O, and S and substituted with 0-5 R 5 ; R 5  is independently at each occurrence, selected from: OH, halogen, \u2014(CR 7 R 7 ) n \u2014C 3-10  carbocycle, \u2014(CR 7 R 7 ) n -heterocycle, and each substituted with 0-3 R 6 ; R 5a  is independently at each occurrence, selected from: \u2014C(\u2550O)OR b , C(\u2550O)NR a R a , \u2014S(O) p R c , \u2014(CR 7 R 7 ) n \u2014C 3-10  carbocycle, \u2014C(\u2550O)\u2014C 3-10  carbocycle, \u2014(CR 7 R 7 ) n -heterocycle, \u2014C(\u2550O)-heterocycle, each substituted with 0-3 R 6 ; R 6  is independently selected from: H, halogen, \u2550O, \u2014(CH 2 ) n OR b , (CH 2 ) n S(O) p R c , \u2014(CH 2 ) n C(\u2550O)R b , \u2014(CH 2 ) n NR a R a , \u2014(CH 2 ) n CN, \u2014(CH 2 ) n C(\u2550O)NR a R a , \u2014(CH 2 ) n NR a C(\u2550O)R b , \u2014(CH 2 ) n NR a C(\u2550O)NR a R a , \u2014(CH 2 ) n NR a C(\u2550O)OR b , \u2014(CH 2 ) n OC(\u2550O)NR a R a , \u2014(CH 2 ) n C(\u2550O)OR b , \u2014(CH 2 ) n S(O) p NR a R a , \u2014(CH 2 ) n NR a S(O) p NR a R a , \u2014(CH 2 ) n NR a S(O) p R, C 1-5  alkyl substituted with 0-3 R e , (CH 2 ) n \u2014C 3-6  carbocyclyl substituted with 0-3 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-3 R e ; R 7  is, independently at each occurrence, selected from: H, C 1-4  alkyl, and (CH 2 ) n \u2014C 3-12  carbocyclyl substituted with 0-3 R e ; R a , at each occurrence, is independently selected from H, C 1-6  alkyl substituted with 0-5 R e , C 2-6  alkenyl substituted with 0-5 R e , C 2-6  alkynyl substituted with 0-5 R e , \u2014(CH 2 ) n \u2014C 3-10 carbocyclyl substituted with 0-5 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-5 R e ; or R a  and R a  together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 R e ; R b , at each occurrence, is independently selected from H, C 1-6  alkyl substituted with 0-5 R e , C 2-6  alkenyl substituted with 0-5 R e , C 2-6  alkynyl substituted with 0-5 R e , \u2014(CH 2 ) n \u2014C 3-10 carbocyclyl substituted with 0-5 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-5 R e ; R c , at each occurrence, is independently selected from C 1-6  alkyl substituted with 0-5 R e , C 2-6 alkenyl substituted with 0-5 R e , C 2-6 alkynyl substituted with 0-5 R e , C 3-6 carbocyclyl substituted with 0-5 R e , and heterocyclyl substituted with 0-5 R e ; R d , at each occurrence, is independently selected from H and C 1-4 alkyl substituted with 0-5 R e ; R e , at each occurrence, is independently selected from C 1-6  alkyl substituted with 0-5 R g , C 2-6  alkenyl, C 2-6  alkynyl, \u2014(CH 2 ) n \u2014C 3-6  cycloalkyl, \u2014(CH 2 ) n \u2014C 4-6  heterocyclyl, \u2014(CH 2 ) n -aryl, \u2014(CH 2 ) n -heteroaryl, F, Cl, Br, CN, NO 2 , \u2550O, CO 2 R f , \u2014(CH 2 ) n OR f , S(O) p R f , C(\u2550O)NR f R f , NR f C(\u2550O)R, S(O) p NR f R f , NR f S(O) p R f , NR f C(\u2550O)OR f , OC(\u2550O)NR f R f  and \u2014(CH 2 ) n NR f R f ; R f , at each occurrence, is independently selected from H, C 1-5 alkyl (optimally substituted with halogen and OH), C 3-6  cycloalkyl, and phenyl, or R f  and R f  together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C 1-4 alkyl; R g , at each occurrence, is independently selected from H, F, Cl, Br, CN, OH, C 1-5 alkyl (optimally substituted with halogen and OH), C 3-6  cycloalkyl, and phenyl, or R f  and R f  together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C 1-4 alkyl; n is independently selected from zero, 1, 2, 3, and 4; and p, at each occurrence, is independently selected from zero, 1, and 2.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 91.0
- Lexical Diversity: 1.16216
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15468230', '15171276', '16309161', '16061365', '16340172']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7758001084183872
- 35 USC 102 Novelty (BERT): 0.5648421913170205
- Combined Prediction Score: 0.7547043167082506
- Mean Citation Score: 401.784548
- Max Citation Score: 425.81107
- Similarity Product: 409.58596596494857

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test