PATENT CLAIM ANALYSIS

Application Number: 15932315
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "488000"]

Abstract:
A device for delivery of a first therapeutic agent and a second therapeutic agent to a site in epithelial tissue includes a first layer having a first, freeze-dried polymeric matrix having first and second opposed surfaces, formed by a composition including chitosan, a hydration promoter, a particle adhesion inhibitor, and a particle aggregation inhibitor, and a plurality of first particles embedded within the first matrix so as to be directly surrounded by, and in contact with, the first matrix, the first particles containing the first therapeutic agent and having a coating around the first therapeutic agent, the coating including chitosan. The device further includes a second layer, adjacent to the first layer, having a second, freeze-dried polymeric matrix containing the second therapeutic agent, the first layer and/or the second layer is configured to be attached to the site in the epithelial tissue.

Claim (Index 20):
A method for manufacturing a multi-layer device for delivery of a first therapeutic agent and a second therapeutic agent to a site in epithelial tissue, the method comprising:\n forming a first precursor mixture comprising a first polymeric matrix precursor and the first therapeutic agent, the first polymeric matrix precursor comprising a plurality of particles, chitosan, a hydration promoter, a particle adhesion inhibitor, and a particle aggregation inhibitor, the plurality of particles containing the first therapeutic agent and having a coating around the first therapeutic agent, the coating comprising chitosan; forming a second precursor mixture comprising a second polymeric matrix precursor and the second therapeutic agent; freezing the first precursor mixture in a first mold containing a first aqueous alcoholic solution at a temperature above the freezing temperature of the first aqueous alcoholic solution and at most \u221240\u00b0 C., to form a frozen first layer precursor; freezing the second precursor mixture in a second mold containing a second aqueous alcoholic solution at a temperature above the freezing temperature of the second aqueous alcoholic solution and at most \u221240\u00b0 C., to form a frozen second layer precursor; applying a salt solution to a portion of the frozen first layer precursor, the frozen second layer precursor, or both, to form a coating on the portion; combining the frozen second layer precursor with the frozen first layer precursor, to form a combined solid; and drying the combined solid to form the multi-layer delivery device, the multi-layer device comprising a first layer comprising a first polymeric matrix with the plurality of particles embedded within the first polymeric matrix and a second layer comprising a second polymeric matrix, the first layer or the second layer configured to be attached to the site in the epithelial tissue.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 88.0
- Lexical Diversity: 2.67797
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15897729', '15436651', '12322443', '12290685', '12290683']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6637863610766288
- 35 USC 102 Novelty (BERT): 0.5539929643812256
- Combined Prediction Score: 0.6528070214070886
- Mean Citation Score: 264.2955
- Max Citation Score: 415.27493
- Similarity Product: 306.2930131702268

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test