PATENT CLAIM ANALYSIS

Application Number: 16030703
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "321000"]

Abstract:
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the MTP inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the MTP inhibitor to the subject. In some embodiments, the method further comprises the administration of one or more other lipid modifying compounds.

Claim (Index 13):
A method of treating a subject suffering from hyperlipidemia or hypercholesterolemia, the method comprising administering to the subject an effective amount of an MTP inhibitor, wherein said administration comprises three step-wise, increasing dose levels of the MTP inhibitor, wherein each dose level is no more than 50% of the immediately following dose level, and wherein the first dose level is about 0.02 to about 0.059 mg/kg/day, the second dose level is about 0.06 mg/kg/day to about 0.19 mg/kg/day, and the third dose level is about 0.2 to about 0.59 mg/kg/day;\n wherein the MTP inhibitor is N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4\u2032-(trifluoromethyl)[1,1\u2032-biphenyl]-2-yl] carbonyl] amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide, methanesulfonate; and wherein each dose level is administered for a period of about 7 to about 35 days.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 95.0
- Lexical Diversity: 1.69231
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15218670', '15155647', '14075483', '13046118', '15605548']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7620236708619953
- 35 USC 102 Novelty (BERT): 0.6262177681043192
- Combined Prediction Score: 0.7484430805862277
- Mean Citation Score: 550.093734
- Max Citation Score: 563.5453
- Similarity Product: 539.872335438466

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test