PATENT CLAIM ANALYSIS

Application Number: 15943538
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-04
Patent Classification: ["424", "450000"]

Abstract:
The disclosure provides compositions and methods of use of formulations effective for the delivery of biologically active molecules and materials, including therapeutic and diagnostic agents, and combinations thereof, to cells, tissues, and living organisms. More particularly, the present invention is related to the incorporation of hydrophobic nanoparticles, such as hydrophobic metal nanoparticles, into the membranes of vesicular delivery vehicles. These hydrophobic nanoparticles enhance the endosomal membrane fusogenicity of the formulations through the promotion of inverted hexagonal phase formation in the lipid bilayers of the vesicular delivery vehicles. As a result, the vesicular delivery vehicles more readily fuse with the endosomal membranes, leading to enhanced endosomal escape of the vesicular delivery vehicle and its contents, thereby facilitating the delivery of the biologically active molecules and materials incorporated within the vesicular delivery vehicles to their sites of action.

Claim (Index 16):
The method of  claim 15 , wherein said payload is selected from the group consisting of ribonucleic acid (RNA), deoxyribonucleic acid (DNA), messenger RNA (mRNA), interfering RNA (iRNA), small interfering RNA (siRNA), micro RNA (miRNA), plasmid DNA (pDNA), and mixtures thereof.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 91.0
- Lexical Diversity: 1.8875
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12004154', '09553639', '15112180', '14425830', '10130951']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7965545109921899
- 35 USC 102 Novelty (BERT): 0.5218248476296428
- Combined Prediction Score: 0.7690815446559351
- Mean Citation Score: 310.805856
- Max Citation Score: 338.25885
- Similarity Product: 256.40468970329755

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test