PATENT CLAIM ANALYSIS

Application Number: 15575778
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2018-10
Patent Classification: ["544", "293000"]

Abstract:
The present invention relates to an improved process for the preparation of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1:2) represented by the following structural formula:

Claim (Index 5):
A process for the preparation of novel crystalline form-R of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1:2) compound of formula-1, comprising of:\n a) Adding a suitable solvent to N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-(2E)-2-butenamide, b) stirring the reaction mixture, c) optionally, treating the reaction mixture with charcoal, d) adding a suitable solvent to the maleic acid, e) stirring the reaction mixture, f) optionally, seeding the crystalline form-R of compound of formula-1 to the compound obtained in step-(e), g) adding the reaction mixture obtained in step-b) or step-c) to the reaction mixture obtained in step-e) or step-f), h) adding water to the reaction mixture obtained in step-g), i) filtering the solid and then drying to get crystalline form-R of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3 S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1:2) compound of formula-1.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 97.0
- Lexical Diversity: 1.46154
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15516382', '15565996', '15553843', '13138429', '11997719']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5259581040353148
- 35 USC 102 Novelty (BERT): 0.526242897688335
- Combined Prediction Score: 0.5259865834006169
- Mean Citation Score: 289.474582
- Max Citation Score: 317.6971
- Similarity Product: 222.4221082224488

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test