PATENT CLAIM ANALYSIS

Application Number: 16060681
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["536", "026800"]

Abstract:
Disclosed is a method for the preparation of intermediates useful in the synthesis of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. Also disclosed is a method of preparing gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate.

Claim (Index 1):
A process for the preparation of gemcitabine-[phenyl (benzoxy-L-alaninyl)] phosphate (Formula I) in substantially diastereoisomerically pure form: the process comprising step a) and optionally step b): a) reacting a compound of Formula II; wherein R 1  represents an electron withdrawing group and a is an integer from 1 to 5, with a compound of Formula III in presence of a base (B1) to provide a compound of Formula IV in substantially diastereomerically pure form; wherein P 1 , P 2  and P 3  independently represents hydrogen or a protecting group; and wherein the compound of formula II is in substantially diastereomerically pure form: and\n b) where any one or more of P 1 , P 2  and P 3  are protecting groups, optionally removing the protecting groups P 1 , P 2  and P 3  from the compound of formula IV to provide gemcitabine-[phenyl (benzoxy-L-alaninyl)] phosphate in substantially diastereomerically pure form.

Metadata:
- Claim Count in Document: 63.0
- Percentile: 94.0
- Lexical Diversity: 1.59091
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15411409', '11125359', '12143433', '11126161', '12528687']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6062151344626675
- 35 USC 102 Novelty (BERT): 0.4978780294775584
- Combined Prediction Score: 0.5953814239641566
- Mean Citation Score: 220.860986
- Max Citation Score: 258.98752
- Similarity Product: 190.67944921966549

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test