PATENT CLAIM ANALYSIS

Application Number: 15743489
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["546", "065000"]

Abstract:
The present invention relates to the compounds of formula I, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with cancers associated with protein kinases, to their use as medicaments for use in the production of inhibition of mTor, pi3k reducing effects in warm¬blooded animals such as humans.

Claim (Index 2):
A compound according to  claim 1 , wherein\n Q1 and Q2 are independently selected from an aryl, a 5-6 membered heterocyclyl or a 9-11 membered bicycloheterocyclyl; preferably Q1 is independently selected from pyridinyl, pyrimidinyl, quinolinyl or quinazolinyl and Q2 is phenyl; Q1 is a halogen when R and R 1  are not presented; preferably a Br or I; Z is N or C\u2014R; preferably is N; R and R 1  are independently selected from H, halogen, halogenC 1 -C 6 alkyl, \u2014C 1 -C 6 alkyl, \u2014OR 7 , or \u2014NR 7 R 8 ; preferably is H, or \u2014NR 7 R 8  R 2  and R 3  are independently selected from H, \u2014OH, \u2014C 1 -C 6 alkyl, \u2014C 1 -C 6 alkoxyl, \u2014C 1 -C 6 alkenyl or \u2014C 1 -C 6 alkynyl; R 2  is not \u2014CF3; preferably are independently selected from H, halogen or \u2014C 1 -C 6 alkyl, and R 2  is not \u2014CF3; R 4  and R 5  are independently selected from H, halogen, halogenC 1 -C 6 alkyl, \u2014C 1 -C 6 alkyl, \u2014OH, \u2014C 1 -C 6 alkoxyl, cycloalkyl; or both R 4  and R 5  can be combined together to form a 3-8 membered saturated or unsaturated ring that can be aliphatic cyclyl or heterocyclyl; preferably are H, halogenC 1 -C 6 alkyl, \u2014C 1 -C 6 alkyl or both combined together to form a saturated aliphatic cyclyl or heterocyclyl ring; R 6  is selected from H, \u2014CH 3  or \u2014CN; preferably is \u2014CH 3  or \u2014CN; R 7  and R 8  are independently selected from H, halogen, \u2014C 1 -C 6 alkyl, \u2014C 1 -C 6 alkylOH, \u2014C 1 -C 6 alkoxyl, \u2014C 1 -C 6 alkylNR 4 R 5 , \u2014C(\u2550O)C 1 -C 6 alkyl, \u2014C(\u2550O)C 1 -C 6 alkyl-R 4 R 5 , \u2014C(\u2550O)C 1 -C 6 alkylOH, \u2014C(\u2550O)C 1 -C 6 alkoxyl, \u2014C(\u2550O)C 1 -C 6 alkylNR 4 R 5 , \u2014C(\u2550O)OC 1 -C 6 alkyl, \u2014C(\u2550O)OC 1 -C 6 alkylOH, \u2014C(\u2550O)OC 1 -C 6 alkoxyl, \u2014C(\u2550O)OC 1 -C 6 alkylNR 4 R 5 , \u2014C(\u2550O)NR 4 C 1 -C 6 alkyl, \u2014C(\u2550O)NR 4 C 1 -C 6 alkylOH, \u2014C(\u2550O)N\u2014R 4 C 1 -C 6 alkoxyl, \u2014C(\u2550O)NR 4 C 1 -C 6 alkylNR 4 R 5 ; preferably are independently selected from H, \u2014C(\u2550O)C 1 -C 6 alkyl, \u2014C 1 -C 6 alkylNR 4 R 5  or \u2014C(\u2550O)C 1 -C 6 alkylNR 4 R 5 ; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 86.0
- Lexical Diversity: 1.42222
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15325593', '14123934', '11294316', '12159742', '11378947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7891120965454126
- 35 USC 102 Novelty (BERT): 0.5904567282842519
- Combined Prediction Score: 0.7692465597192966
- Mean Citation Score: 292.0053919999998
- Max Citation Score: 508.21484
- Similarity Product: 445.8217526663112

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test