PATENT CLAIM ANALYSIS

Application Number: 15942587
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-02
Patent Classification: ["514", "04400A"]

Abstract:
The present application relates to nucleic acid compounds, compositions comprising same and methods of use thereof for treatment of various diseases, disorders and conditions. The compounds are preferably chemically synthesized and modified double-stranded nucleic acid molecules which down regulate expression of a p53 gene.

Claim (Index 29):
A double-stranded nucleic acid molecule comprising a sense strand and an antisense strand, the molecule having the structure: (A) 5\u2032\u2003z\u2033-GGGCCUGACUCAGACUGAU-Z\u2032\u20033\u2032\u2003sense strand (SEQ ID NO: 19) \u2003\u2003\u2003\u2003\u2003|||||||||||||||||| 3\u2032\u2003Z-CCCGGACUGAGUCUGACUA 5\u2032\u2003antisense strand (SEQ ID NO: 32); wherein each one of A, C, G, U is independently an unmodified ribonucleotide, a modified ribonucleotide, an unmodified deoxyribonucleotide, a modified deoxyribonucleotide, or an unconventional moiety selected from the group consisting of a mirror nucleotide, an unmodified deoxyribonucleotide, a modified deoxyribonucleotide, a threose nucleic acid (TNA), a nucleotide analogue and a ribonucleotide joined to an adjacent ribonucleotide by a 2\u2032-5\u2032 internucleotide phosphate bond; wherein each \u201c|\u201d represents base pairing between the antisense and the corresponding sense strand; wherein each of Z and Z\u2032 is independently present or absent, but if present is independently 1-5 consecutive nucleotides, 1-5 consecutive nucleotide analogues or 1-5 consecutive non-nucleotide moieties or a combination thereof, or a conjugate moiety, covalently attached at the 3\u2032 terminus of the strand in which it is present; wherein z\u2033 is present or absent, but if present is a capping moiety, or a conjugate moiety covalently attached at the 5\u2032 terminus of the sense strand; and wherein the sequence of the sense strand is complementary to the sequence of the antisense strand; with the proviso that not each nucleotide is a deoxyribonucleotide; or a pharmaceutically acceptable salt of such molecule.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 91.0
- Lexical Diversity: 1.26316
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14421845', '14426513', '13700942', '15433400', '13521033']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8096964982613076
- 35 USC 102 Novelty (BERT): 0.5819924560847702
- Combined Prediction Score: 0.7869260940436539
- Mean Citation Score: 425.007888
- Max Citation Score: 516.79877
- Similarity Product: 411.8393600400889

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test