PATENT CLAIM ANALYSIS

Application Number: 15745714
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["549", "022000"]

Abstract:
The invention relates to Pro-drugs, comprising red-ox-sensitive cleavage sites. The compounds may be utilized in medical practice for targeting of si RNA, antisense oligonucleotides or protein-based therapeutics to the cytoplasmatic compartment of cells both in vitro or in vivo, in a subject in need.

Claim (Index 13):
A method for redox-dependent cleavage of a Pro-drug, said method comprising (A). Incorporation of a ROSS in the structure of the Pro-drug, wherein said ROSS has the following structural motifs: (i). a cyclic hydrocarbon disulfide moiety; (ii). A carbonyl group, positioned at 5-7 atoms from at least one of the sulfur atoms; and (iii). A leaving group, attached to the carbonyl group through carbamate, ester or amide bonds; (B). Maintaining the Pro-drug initially in an oxidative environment; and (C). Transferring the Pro-drug into an ambient reductive environment, thereby providing the required conditions for ring opening, cleavage of the pro-drug, and release of the active drug.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.28947
- Patent Class: 549.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15691821', '15222559', '14872179', '14830799', '10585928']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7312780960979762
- 35 USC 102 Novelty (BERT): 0.5194980272784432
- Combined Prediction Score: 0.710100089216023
- Mean Citation Score: 271.216316
- Max Citation Score: 300.4459
- Similarity Product: 185.07694770948888

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test