PATENT CLAIM ANALYSIS

Application Number: 16126300
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-02
Patent Classification: ["530", "321000"]

Abstract:
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.

Claim (Index 32):
The method of  claim 25 , wherein the peptidomimetic macrocycle has the formula: wherein:\n each A, C, D, and E is independently a natural or non-natural amino acid, and each D and E independently optionally includes a capping group; \n each B is independently a natural or non-natural amino acid, amino acid analog, or \n each R 1  and R 2  is independently \u2014H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, or heterocycloalkyl, unsubstituted or substituted with halo-; each R 3  is independently hydrogen, alkyl, alkenyl, alkynyl, arylalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, cycloaryl, or heterocycloaryl, optionally substituted with R 5 ; each L is independently a macrocycle-forming linker of the formula \u2014L 1 \u2014L 2 \u2014; each L 1  and L 2  is independently alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, cycloarylene, heterocycloarylene, or [\u2014R 4 \u2014K\u2014R 4 \u2014] n , each optionally substituted with R 5 ; each R 4  is independently alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, arylene, or heteroarylene; each K is independently O, S, SO, SO 2 , CO, CO 2 , or CONR 3 ; each R 5  is independently halogen, alkyl, \u2014OR 6 , \u2014N(R 6 ) 2 , \u2014SR 6 , \u2014SOR 6 , \u2014SO 2 R 6 , \u2014CO 2 R 6 , a fluorescent moiety, a radioisotope or a therapeutic agent; each R 6  is independently \u2014H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkylalkyl, heterocycloalkyl, a fluorescent moiety, a radioisotope or a therapeutic agent; each R 7  is independently \u2014H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, cycloaryl, or heterocycloaryl, each optionally substituted with R 5 , or forms part of a cyclic structure with a D residue; each R 8  is independently \u2014H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, cycloaryl, or heterocycloaryl, each optionally substituted with R 5 , or forms part of a cyclic structure with an E residue; each v and w is independently an integer from 1-1000; u is an integer from 1-10; each x, y and z is independently an integer from 0-10; and each n is independently an integer from 1-5.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 97.0
- Lexical Diversity: 1.11765
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13816880', '15135098', '14498063', '13767852', '15229517']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6642329005011101
- 35 USC 102 Novelty (BERT): 0.6999467663368631
- Combined Prediction Score: 0.6678042870846854
- Mean Citation Score: 711.03794
- Max Citation Score: 775.3979
- Similarity Product: 704.992288905525

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test