PATENT CLAIM ANALYSIS

Application Number: 16021540
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["435", "069700"]

Abstract:
The present invention provides a method for designing a re-targeted toxin conjugate for use in treating a medical condition or disease. Also provided, is the use of said conjugates in the manufacture of a medicament for treating medical conditions or diseases. The conjugates include a Targeting Moiety, which directs the conjugate to a desired target cell, and are characterised by a Targeting Moiety that increases exocytic fusion in the target cell. The present invention also provides methods for identifying agonists suitable for use as Targeting Moieties, and methods for preparing conjugates comprising said Targeting Moieties.

Claim (Index 1):
A method of preparing a fusion protein for the inhibition or reduction of secretion of an extracellular mediator from a target cell, said method comprising:\n (a) selecting a target cell that secretes a polypeptide extracellular mediator associated with a medical condition or disease; (b) identifying a polypeptide agonist that increases exocytic fusion and secretion of said extracellular mediator from said target cell upon binding of the polypeptide agonist to a receptor on said target cell to form a polypeptide agonist-receptor complex, wherein said polypeptide agonist-receptor complex undergoes endocytosis to be incorporated into an endosome within said target cell; and (c) preparing by recombinant expression said fusion protein, said fusion protein comprising:\n (i) the polypeptide agonist identified by step (b); \n (ii) a clostridial neurotoxin protease; and \n (iii) a clostridial neurotoxin translocation domain; \n wherein said fusion protein inhibits or reduces the secretion of said polypeptide extracellular mediator.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 94.0
- Lexical Diversity: 1.80702
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13944427', '11792210', '13212868', '13343892', '15258282']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6302469722211954
- 35 USC 102 Novelty (BERT): 0.5067172517912153
- Combined Prediction Score: 0.6178940001781974
- Mean Citation Score: 283.229752
- Max Citation Score: 292.6719
- Similarity Product: 213.28031807191368

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test