PATENT CLAIM ANALYSIS

Application Number: 16081818
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-05
Patent Classification: ["514", "04400A"]

Abstract:
Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds the PSL2 motif to inhibit the influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided are methods for screening a candidate agent for the ability to inhibit influenza A virus in a cell, the method comprising: contacting a sample with a candidate agent; and determining whether the candidate agent specifically binds to the PSL2 motif of vRNA. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence complementary to a PB2 vRNA region that find use in the subject methods.

Claim (Index 5):
The compound of  claim 1 , wherein the oligonucleotide comprises a sequence selected from: (SEQ\u2003ID\u2003NO:\u200345) 5\u2032 ACCAAAAGAAT\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200346) 5\u2032 TGGCCATCAAT\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200347) 5\u2032 TAGCATACTTA\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200348) 5\u2032 CCAAAAGA\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200349) 5\u2032 CATACTTA\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200350) 5\u2032 CAGACACGACCAAAA\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200351) 5\u2032 TACTTACTGACAGCC\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200352) 5\u2032 AGACACGACCAAAAG\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200353) 5\u2032 ACCAAAAGAAT\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200354) 5\u2032 TGGCCATCAAT\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200355) 5\u2032 TAGCATACTTA\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200356) 5\u2032 CGACCAAAAGAATTC\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200357) 5\u2032 CGACCAAAAGAATTC\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200358) 5\u2032 GATGGCCATCAATTA\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200359) 5\u2032 GATGGCCATCAATTA\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200360) 5\u2032 TCTAGCATACTTACT\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200361) 5\u2032 TCTAGCATACTTACT\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200362) 5\u2032 GAATTCGGATGGCCA\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200363) 5\u2032 GGCCATCAATTAGTG\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200364) 5\u2032 TTCGGATGGCCATCA\u20033\u2032;   (SEQ\u2003ID\u2003NO:\u200365) 5\u2032 AGCCAGACAGCGA\u20033\u2032; and   (SEQ\u2003ID\u2003NO:\u200366) 5\u2032 GACAGCCAGACAGCA\u20033\u2032.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 96.0
- Lexical Diversity: 2.17188
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15203581', '15865364', '14699213', '13594611', '14332121']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6695205763911433
- 35 USC 102 Novelty (BERT): 0.5287670992888736
- Combined Prediction Score: 0.6554452286809164
- Mean Citation Score: 298.882436
- Max Citation Score: 305.1271700000001
- Similarity Product: 167.68199876834638

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test