PATENT CLAIM ANALYSIS

Application Number: 15902301
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["435", "189000"]

Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

Claim (Index 3):
The engineered ketoreductase polypeptide of  claim 1 , wherein the ketoreductase polypeptide amino acid sequence further comprises at least one additional substitution selected from:\n the residue corresponding to X7 is a non-polar, polar, or constrained residue; the residue corresponding to X94 is a polar, basic, aliphatic, or non-polar residue; the residue corresponding to X96 is a constrained, aliphatic, non-polar, acidic, or polar residue; the residue corresponding to X108 is a basic, constrained, or aromatic residue; the residue corresponding to X117 is a non-polar or polar residue; the residue corresponding to X147 is a non-polar or alphatic residue; the residue corresponding to X157 is a polar or acidic residue; the residue corresponding to X173 is an acidic or non-polar residue; the residue corresponding to X206 is a polar or non-polar residue; and the residue corresponding to X223 is an aliphatic or non-polar residue.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.43243
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15184018', '12197286', '13110789', '15711070', '15211505']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7654855542699788
- 35 USC 102 Novelty (BERT): 0.6515155519717777
- Combined Prediction Score: 0.7540885540401586
- Mean Citation Score: 613.561448
- Max Citation Score: 670.1730299999998
- Similarity Product: 607.6696639273111

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test