PATENT CLAIM ANALYSIS

Application Number: 15979319
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "015200"]

Abstract:
The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.

Claim (Index 1):
A Method for preparing a variant of albumin, fragments thereof or fusion polypeptide comprising said variant albumin or fragment thereof, comprising following steps:\n a. Providing a nucleic acid encoding a parent albumin having at least 80% sequence identity to SEQ ID NO: 2; b. Modifying the sequence of step a., to encode a variant albumin, fragments thereof or fusion polypeptide comprising said variant albumin or fragment thereof having one or more substitutions corresponding to the substitutions in SEQ ID NO: 2 selected among:\n Q417A,C,D,E,F,G,H,I,K,L,M,N,P,R,S,T,V,W,Y; \n H440A,C,D,E,F,G,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n A490C,D,E,F,G,H,I,K,L,M,N,P,R,S,T,V,W,Y \n E492A,C,D,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n V493A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T.W,Y; \n D494A,C,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n E495A,C,D,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n T496A,C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,V,W,Y; \n P499A,C,D,E,F,G,H,I,K,L,M,N,Q,R,S,T,V,W,Y; \n K500A,C,D,E,F,G,H,I,L,M,N,Q,R,S,T,V,W,Y; \n E501A,C,D,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n N503A,C,D,E,F,G,H,I,K,L,M,P,Q,R,S,T,V,W,Y; \n A504C,D,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n E505A,C,D,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n T506A,C,D,F,G,H,I,K,L,M,N,P,Q,R,S,V,W,Y; \n H510A,C,D,F,G,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n H535A,C,D,F,G,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n K536A,C,D,E,F,G,H,I,L,M,N,P,Q,R,S,T,V,W,Y; \n P537A,C,D,E,F,G,H,I,K,L,M,N,Q,R,S,T,V,W,Y; \n K538A,C,D,E,F,G,H,I,L,M,N,P,Q,R,S,T,V,W,Y; \n T540A,C,D,E,F,G,H,I,L,M,N,P,Q,R,S,V,W,Y; \n K541A,C,D,E,F,G,H,I,L,M,N,P,Q,R,S,T,V,W,Y; \n E542A,C,D,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n D550A,C,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n K573A,C,D,E,F,G,H,I,L,M,N,P,Q,R,S,T,V,W,Y; \n K574A,C,D,E,F,G,H,I,L,M,N,P,Q,R,S,T,V,W,Y; \n Q580A,C,D,E,F,G,H,I,K,L,M,N,P,R,S,T,V,W,Y; \n A581C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n A582C,D,E,F,G,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; or \n G584A,C,D,E,F,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y; \n c. Introducing the modified sequence of step b., in a suitable host cell; d. Growing the cells in a suitable growth medium under condition leading to expression of the variant of albumin, fragments thereof or fusion polypeptide comprising said variant albumin or fragment thereof; and e. Recovering the variant of albumin, fragments thereof or fusion polypeptide comprising said variant albumin or fragment thereof from the growth medium; wherein the variant of albumin, fragments thereof or fusion polypeptide comprising said variant albumin or fragment thereof, has an altered plasma half-life compared with the parent albumin, fragments thereof or fusion polypeptide comprising said variant albumin or fragment thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.34615
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13504326', '13463944', '13640235', '14685112', '14385631']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7790924141897917
- 35 USC 102 Novelty (BERT): 0.6587237134129974
- Combined Prediction Score: 0.7670555441121123
- Mean Citation Score: 602.7781160000002
- Max Citation Score: 713.5717
- Similarity Product: 590.2539600462079

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test