PATENT CLAIM ANALYSIS

Application Number: 15748205
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "217000"]

Abstract:
Provided in some embodiments are compounds of Formula A, as defined herein, that modulate the activity of 5-HT2C receptor. Also provided in some embodiments are methods, such as, for weight management, inducing satiety, and decreasing food intake, and for preventing and treating obesity, antipsychotic-induced weight gain, type 2 diabetes, Prader-Willi syndrome, tobacco/nicotine dependence, drug addiction, alcohol addiction, pathological gambling, reward deficiency syndrome, and sex addiction), obsessive-compulsive spectrum disorders and impulse control disorders (including nail-biting and onychophagia), sleep disorders (including insomnia, fragmented sleep architecture, and disturbances of slow-wave sleep), urinary incontinence, psychiatric disorders (including schizophrenia, anorexia nervosa, and bulimia nervosa), Alzheimer disease, sexual dysfunction, erectile dysfunction, epilepsy, movement disorders (including parkinsonism and antipsychotic-induced movement disorder), hypertension, dyslipidemia, nonalcoholic fatty liver disease, obesity-related renal disease, and sleep apnea.

Claim (Index 37):
The compound of  claim 1 , wherein the compound is selected from the following compounds, and pharmaceutically acceptable salts, solvates, and hydrates thereof:\n 8\u2032-ethyl-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclopropane-1,6\u2032-cyclopropane-7\u2032,1\u2033-naphtho[1,8-cd]-azepine] (Compound 101); 6\u2032,6\u2032-dimethyl-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,7\u2032-naphtho[1,8-cd]azepine] (Compound 102); (S)-6\u2032,6\u2032-dimethyl-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,7\u2032-naphtho[1,8-cd]azepine] (Compound 103); (R)-6\u2032,6\u2032-dimethyl-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,7\u2032-naphtho[1,8-cd]azepine] (Compound 104); 8\u2032-fluoro-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclopropane-1,6\u2032-cyclopropane-7\u2032,1\u2033-naphtho[1,8-cd]-azepine] (Compound 105); 8-bromo-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 106); 1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 107); 2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclobutane-1,6\u2032-cyclopropane-7\u2032,1\u2033-naphtho[1,8-cd]-azepine] (Compound 108); 8-bromo-7,7-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 109); (S)-7,7-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 110); 8-chloro-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 111); (R)-7\u2032,7\u2032-dimethyl-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,7\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,6\u2032-naphtho[1,8-cd]azepine] (Compound 112); (R)-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclopropane-1,6\u2032-cyclopropane-7\u2032,1\u2033-naphtho[1,8-cd]-azepine] (Compound 113); (S)-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclopropane-1,6\u2032-cyclopropane-7\u2032,1\u2033-naphtho[1,8-cd]-azepine] (Compound 114); (S)-7\u2032,7\u2032-dimethyl-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,7\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,6\u2032-naphtho[1,8-cd]azepine] (Compound 115); 8\u2032-methyl-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclopropane-1,6\u2032-cyclopropane-7\u2032,1\u2033-naphtho[1,8-cd]-azepine (Compound 116); 2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclohexane-1,7\u2032-naphtho[1,8-cd]azepine](Compound 117); (7aR)-5,6,7,7a,8,8a,9,10,11,11a-decahydro-4H-cyclopenta[5,6]naphtho[1,8-cd]azepine (Compound 118); 8\u2032-fluoro-6\u2032,6\u2032-dimethyl-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,7\u2032-naphtho[1,8-cd]azepine] (Compound 119); 7-cyclopropyl-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 120); 7\u2032,7\u2032-dimethyl-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,7\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,6\u2032-naphtho[1,8-cd]azepine] (Compound 121); (R)-7,7-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 122); (S)-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,7\u2032-naphtho[1,8-cd]azepine](Compound 123); (S)-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclobutane-1,7\u2032-naphtho[1,8-cd]azepine](Compound 124); (R)-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclobutane-1,7\u2032-naphtho[1,8-cd]azepine](Compound 125); 8-methoxy-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 126); 8-cyclopropyl-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 127); 2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,7\u2032-naphtho[1,8-cd]azepine](Compound 128); 2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclopentane-1,6\u2032-cyclopropane-7\u2032,1 naphtho[1,8-cd]-azepine] (Compound 129); 2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclopropane-1,6\u2032-cyclopropane-7\u2032,1\u2033-naphtho[1,8-cd]-azepine] (Compound 130); 2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclobutane-1,7\u2032-naphtho[1,8-cd]azepine](Compound 131); (7aS)-5,6,7,7a,8,8a,9,10,11,11a-decahydro-4H-cyclopenta[5,6]naphtho[1,8-cd]azepine (Compound 132); (R)-8\u2032-fluoro-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclopropane-1,6\u2032-cyclopropane-7\u2032,1\u2033-naphtho[1,8-cd]-azepine] (Compound 133); (S)-8\u2032-fluoro-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032-pentahydro-1\u2032H-dispiro[cyclopropane-1,6\u2032-cyclopropane-7\u2032,1\u2033-naphtho[1,8-cd]-azepine] (Compound 134); 7,7-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 135); (R)-2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclopropane-1,7\u2032-naphtho[1,8-cd]azepine](Compound 136); 2\u2032,3\u2032,4\u2032,4a\u2032,5\u2032,6\u2032-hexahydro-1\u2032H-spiro[cyclopentane-1,7\u2032-naphtho[1,8-cd]azepine](Compound 137); 8-fluoro-1,2,3,4,4a,5,6,7-octahydronaphtho[1,8-cd]azepine (Compound 138); 1,1-dimethyl-3,3a,4,5,6,7-hexahydro-1H-isochromeno[5,4-cd]azepine (Compound 139); and 5,6,7,7a,8,8a,9,10,11,11a-decahydro-4H-cyclopenta[5,6]naphtho[1,8-cd]azepine (Compound 140).

Metadata:
- Claim Count in Document: 140.0
- Percentile: 86.0
- Lexical Diversity: 1.83871
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15567116', '13060477', '12909319', '14887171', '14486959']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7276925315402931
- 35 USC 102 Novelty (BERT): 0.5339148911017415
- Combined Prediction Score: 0.708314767496438
- Mean Citation Score: 242.303694
- Max Citation Score: 341.7862
- Similarity Product: 276.0146858911276

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test