PATENT CLAIM ANALYSIS

Application Number: 16025087
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "210210"]

Abstract:
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

Claim (Index 10):
A process for preparing the compound of formula (I) as defined in  claim 1 , comprising\n [A] reacting a compound of formula (II) in which A, R 1 , R 2 , R 4 , R 5  and R 6  each have the meanings given in  claim 1 , and T 1  represents (C 1 -C 4 )-alkyl or benzyl, in an inert solvent in the presence of a suitable base or acid to give a carboxylic acid of the formula (III) in which A, R 1 , R 2 , R 4 , R 5  and R 6  each have the meanings given above, reacting the compound of formula (III) in an inert solvent under amide coupling conditions with an amine of the formula (IV-A) or (IV-B) in which L 1A , L 1B , L 1C , L 2 , R 7 , R 8 , R 9 , and R 10  each have the meanings given in  claim 1 , and R 11A , R 12A  and R 13A  have the meanings given in  claim 1  for R 11 , R 12  and R 13 , respectively, or represent an amino protective group, for example tert-butoxycarbonyl, benzyloxycarbonyl or benzyl, or [B] reacting a compound of formula (III-B) in which R 2 , R 4 , R 5  and R 6  each have the meanings given above, in an inert solvent under amide coupling conditions with an amine of the formula (IV) to give a compound of the formula (I-A) and (I-B), in which R 2 , R 4 , R 5 , R 6 , L 1A , L 1B , L 1C , L 2 , R 7 , R 8 , R 9 , R 10 , R 11A , R 12A  and R 13A  each have the meanings given above, from this compound, the benzyl group is subsequently removed using methods known to the person skilled in the art and the resulting compound of formula (V-A) or (V-B) in which R 2 , R 4 , R 5 , R 6 , L 1A , L 1B , L 1C , L 2 , R 7 , R 8 , R 9 , R 10 , R 11A , R 12A  and R 13A  each have the meanings given above, is reacted in an inert solvent in the presence of a suitable base with a compound of formula (VI) in which A and R 1  have the meanings given in  claim 1 , and\n X 1  represents a leaving group selected from the group consisting of chlorine, bromine, iodine, mesylate, triflate or tosylate, \n removing any protective groups present, thereby producing a compound of formula (I), and optionally converting the compound of formula (I) with the appropriate (i) solvent and/or (ii) acid or base into a solvate, salt and/or solvate of the salt thereof.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 95.0
- Lexical Diversity: 1.68571
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15447205', '13789655', '14070180', '14909881', '13789414']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8581683039029632
- 35 USC 102 Novelty (BERT): 0.8098465818387366
- Combined Prediction Score: 0.8533361316965405
- Mean Citation Score: 850.3155519999997
- Max Citation Score: 1035.4594
- Similarity Product: 1023.201982367766

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test