PATENT CLAIM ANALYSIS

Application Number: 15869633
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-04
Patent Classification: ["424", "093700"]

Abstract:
The present invention discloses a method for remolding bone marrow microenvironment in a subject having an impaired bone marrow microenvironment, which comprises implanting a composition comprising isolated mesenchymal stromal cells (MSCs) into the bone marrow cavity of the subject. The method of the present invention successfully remolds the bone marrow microenvironment, recovers the normal hematopoiesis of bone marrow, inhibits/delays the pathological process of leukemia and significantly prolongs the survival period. In addition, the method according to the present invention can be used for the treatment of hematologic tumors such as leukemia and aplastic anemia (AA), which is safe and effective but has no side effects.

Claim (Index 15):
The method according to  claim 13 , wherein the hematologic tumor is juvenile myelomonocytic leukemia or chronic myelomonocytic leukemia.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.64789
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13821288', '11999055', '13762887', '09914508', '15868721']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7797057701651182
- 35 USC 102 Novelty (BERT): 0.5348896519786066
- Combined Prediction Score: 0.7552241583464671
- Mean Citation Score: 350.51610199999993
- Max Citation Score: 372.63153
- Similarity Product: 234.6068746684456

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test