PATENT CLAIM ANALYSIS

Application Number: 16060377
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "278000"]

Abstract:
Disclosed a method of treating a disease or a disorder characterized by protease activity. A pharmaceutical composition for treating a disease or a disorder characterized by protease activity is further disclosed. A method of detecting a cysteine protease from a biological sample is also disclosed.

Claim (Index 14):
A method of detecting a cysteine protease in a sample comprising the steps of:\n a) contacting a sample comprising said cysteine protease with one or more compounds of selected from compound IV: and compound V or a compound represented by Formula I: b) subjecting the sample to a condition that allows for selective binding of the cysteine protease with said compound, wherein: R1 is CH 2 , C 2 -C 4  alkyl or is represented by the structure of Formula II: such that Formula I is in the form of Formula Ia: wherein: R2, R3, R4, R7, R9, R10, R11 are independently selected at each occurrence from hydrogen or C1-C8-alkyl optionally substituted by hydroxyl; R6 and R12 are independently C1-C8 alkyl; each R5 and R8 represents 0, 1, 2, 3, 4, or 5 substituents independently selected at each occurrence from the group consisting of: hydroxy, halogen, cyano, C 1 -C 4  alkyl, C 1 -C 4  alkoxy, C 1 -C 4  haloalkyl, C 1 -C 4  haloalkoxy, \u2014SO 2 \u2014R 13 , \u2014P(O)(OR 14 )(OR 15 ), \u2014C(O)\u2014NR 14 R 15 , \u2014N(CH 3 )\u2014CO\u2014O\u2014(C 1 -C 4 ) alkyl, \u2014NH\u2014CO\u2014O\u2014(C 1 -C 4 ) alkyl, \u2014NH\u2014CO\u2014(C 1 -C 4 )alkyl, \u2014N(CH 3 )\u2014CO\u2014(C 1 -C 4 ) alkyl, \u2014NH\u2014(CH 2 ) 2 \u2014OH; R 13  is selected from: C 1 -C 4  alkyl, NH 2 , or \u2014(CH 2 ) 2 \u2014OH; R 14  is selected from: hydrogen or C 1 -C 4  alkyl; and R 15  is selected from: hydrogen, C 1 -C 4  alkyl, \u2014(CH 2 ) 2 \u2014OH, \u2014(CH 2 ) 2 \u2014O\u2014CH 3 , \u2014(CH 2 ) 3 \u2014OH, \u2014(CH 2 ) 3 \u2014O\u2014CH 3 , 3-oxetany.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 94.0
- Lexical Diversity: 1.84615
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14376361', '15192113', '11338147', '12138806', '14206051']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7099374925405778
- 35 USC 102 Novelty (BERT): 0.515087570687385
- Combined Prediction Score: 0.6904525003552585
- Mean Citation Score: 221.762612
- Max Citation Score: 224.95668
- Similarity Product: 132.63080400313854

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test