PATENT CLAIM ANALYSIS

Application Number: 16132411
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["514", "261100"]

Abstract:
Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Claim (Index 25):
A method for forming a compound of formula comprising the step of reacting a compound of formula and an appropriate phenyl- or heteroaryl-boronic acid derivative, a phenyl- or heteroaryl-trialkylstannane derivative, or a phenyl- or heteroaryl-zinc halide derivative, in the presence of a palladium catalyst and a base, wherein:\n R is \u2014(CR a R b )\u2014O\u2014R 2 ; \n R a  is H or alkyl; \n R b  is H or alkyl; or R a  and R b  together with the atom to which they are attached form a 3 to 8 membered saturated hydrocarbon ring or form a 4 or 8 membered saturated heterocyclic ring comprising a ring member selected from O, N(R 3 ) and S; \n R 1  is phenyl or heteroaryl, wherein the phenyl or the heteroaryl group may be optionally substituted with alkyl, alkoxy, halo or \u2014CN; \n R 2  is H, alkyl, cycloalkyl or heterocycloalkyl, wherein the alkyl or cycloalkyl may \n optionally be substituted with halo, alkoxy or heterocycloalkyl; and\n R3 is H or alkyl; \n wherein:\n heteroaryl is a 5 or 6 membered aromatic ring, comprising one or two ring members selected from N, N(R 4 ), S and O; \n alkyl (or the alkyl group of the alkoxy group) is a linear or branched saturated hydrocarbon containing up to 10 carbon atoms; \n heterocycloalkyl is a C-linked or N-linked 3 to 10 membered non-aromatic, monocyclic ring, wherein the heterocycloalkyl ring comprises 1, 2 or 3 ring members independently selected from N, N(R 4 ), S(O) q  and O; \n R 4  is H or alkyl; and \n q is 0, 1 or 2.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 97.0
- Lexical Diversity: 1.35135
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15172126', '12997721', '14618829', '13889921', '15682346']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7760706208741993
- 35 USC 102 Novelty (BERT): 0.5582305024939587
- Combined Prediction Score: 0.7542866090361752
- Mean Citation Score: 421.637286
- Max Citation Score: 441.61008
- Similarity Product: 308.6290119475365

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test