PATENT CLAIM ANALYSIS

Application Number: 15887228
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "04400A"]

Abstract:
Methods for modulating T-type calcium channel activity without directly targeting the T-type calcium channels are provided that include modulating kelch-like protein 1 (KLHL1) levels in a subject by providing a small hairpin RNA (shRNA) that targets a KLHL1 gene, and then administering the shRNA to the subject in an amount sufficient to modulate KLHL1 gene expression. The KLHL1 level directly effects current activity in T-type calcium channels and therefore modulation of KLHL1 gene expression indirectly modulates current activity in T-type calcium channels. The methods may be implemented with, for example, an shRNA molecule suitable for modulating a KLHL1 level in the subject which may be provided as a plasmid encoding the shRNA molecule or an adeno-associated virus vector encoding the shRNA molecule. Methods of identifying compounds that modulate current activity in T-type calcium channels by determining an effect of the compound on KLHL1 gene expression are also provided.

Claim (Index 2):
The method of  claim 1 , wherein the KLHL1 level directly effects current activity in T-type calcium channels and the shRNA is administered to the subject in an amount sufficient to modulate the current activity in the T-type calcium channels.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 88.0
- Lexical Diversity: 2.06494
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15273079', '14427332', '14690038', '15335466', '15442521']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7537062966224275
- 35 USC 102 Novelty (BERT): 0.6636669851783413
- Combined Prediction Score: 0.7447023654780189
- Mean Citation Score: 319.080718
- Max Citation Score: 635.87775
- Similarity Product: 633.3879020400793

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test