PATENT CLAIM ANALYSIS

Application Number: 16228539
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "261100"]

Abstract:
The invention relates to a compound of formula (I) wherein R 1  to R 4  and n are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Claim (Index 8):
The compound according to  claim 1 , selected from the group consisting of:\n 2-({5-tert-butyl-7-[(3S)-3-hydroxypyrrolidin-1-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)benzene-1-sulfonyl fluoride; (2-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}phenyl)methanesulfonyl fluoride; [2-({5-tert-butyl-7-[(3S)-3-hydroxypyrrolidin-1-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)phenyl]methanesulfonyl fluoride; 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-{[2-(isothiocyanatomethyl)phenyl]methyl}-3H-[1,2,3]triazolo[4,5-d]pyrimidine; (3S)-1-(5-tert-butyl-3-{[2-(isothiocyanatomethyl)phenyl]methyl}-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol; 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[(2-isothiocyanatophenyl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 2-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}benzene-1-sulfonyl fluoride; 2-{[(2-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}phenyl)methyl]disulfanyl}ethan-1-amine; 2-{[(2-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}phenyl)methyl]disulfanyl}ethan-1-ol; 2-[(2-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}phenyl)disulfanyl]ethan-1-ol; 2-[(2-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}phenyl)disulfanyl]ethan-1-amine; 2-{[2-({5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)phenyl]disulfanyl}ethan-1-amine; 2-({[2-({5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)phenyl]methyl}disulfanyl)ethan-1-amine; 2-({5-[difluoro(phenyl)methyl]-7-[(3S)-3-hydroxypyrrolidin-1-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)benzene-1-sulfonyl fluoride; 2-({5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)benzene-1-sulfonyl fluoride; [2-({5-[difluoro(phenyl)methyl]-7-[(3S)-3-hydroxypyrrolidin-1-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)phenyl]methanesulfonyl fluoride; [2-({5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)phenyl]methanesulfonyl fluoride; (3S)-1-(5-[difluoro(phenyl)methyl]-3-{[2-(isothiocyanatomethyl)phenyl]methyl}-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol; 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3-{[2-(isothiocyanatomethyl)phenyl]methyl}-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3-[(2-isothiocyanatophenyl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 1-{5-tert-butyl-3-[(2-chlorophenyl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}pyrrolidine-3-thiol; 1-{5-tert-butyl-3-[(2-chlorophenyl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}azetidine-3-thiol; (3S)-1-{5-tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}pyrrolidine-3-thiol; (3R)-1-{5-tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}pyrrolidine-3-thiol; (3S)-1-{5-tert-butyl-3-[(2-chlorophenyl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}pyrrolidine-3-thiol; (3R)-1-{5-tert-butyl-3-[(2-chlorophenyl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}pyrrolidine-3-thiol 7-(3-azidopyrrolidin-1-yl)-5-tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(3-isothiocyanatopyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 5-tert-butyl-7-(3-isothiocyanatopyrrolidin-1-yl)-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 7-(3-azidopyrrolidin-1-yl)-5-tert-butyl-3-[(2-chlorophenyl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 5-[difluoro(phenyl)methyl]-7-[3-(methyldisulfanyl)pyrrolidin-1-yl]-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 3-[(2-chlorophenyl)methyl]-5-[difluoro(phenyl)methyl]-7-[3-(methyldisulfanyl)pyrrolidin-1-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 7-(3-azidopyrrolidin-1-yl)-5-[difluoro(phenyl)methyl]-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 7-(3-azidopyrrolidin-1-yl)-3-[(2-chlorophenyl)methyl]-5-[difluoro(phenyl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 3-[(2-chlorophenyl)methyl]-5-[difluoro(phenyl)methyl]-7-(3-isothiocyanatopyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 5-[difluoro(phenyl)methyl]-7-(3-isothiocyanatopyrrolidin-1-yl)-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 2-[[5-difluoro(phenyl)methyl]-7-[(3S)-3-hydroxypyrrolidin-1-yl]triazolo[4,5-d]pyrimidin-3-yl]methyl]benzenesulfonyl fluoride; 2-[[2-[[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]phenyl]methyldisulfanyl]ethanol; 2-[[5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]benzenesulfonyl fluoride; 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2-[2-(pyridin-2-yldisulfanyl)ethyl]phenyl]methyl]triazolo[4,5-d]pyrimidine; 2-[2-[2-[[5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]phenyl]ethyldisulfanyl]ethanol; 2-[2-[2-[[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]phenyl]ethyldisulfanyl]ethanol; 3-[[2-[2-(benzotriazol-1-ylsulfonyl)ethyl]phenyl]methyl]-5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidine; 2-[2-[[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]phenyl]ethanesulfonyl fluoride; 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2-[2-(pyridin-2-yldisulfanyl)ethyl]phenyl]methyl]triazolo[4,5-d]pyrimidine; 2-[2-[2-[[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]phenyl]ethyldisulfanyl]ethanamine; 2-[2-[2-[[5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]phenyl]ethyldisulfanyl]ethanamine; 3-[2-[2-[[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]phenyl]ethyldisulfanyl]propane-1,2-diol; 2-[[2-[[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]phenyl]disulfanyl]ethanol; 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2-(pyridin-2-yldisulfanyl)phenyl]methyl]triazolo[4,5-d]pyrimidine; and 2-[[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)triazolo[4,5-d]pyrimidin-3-yl]methyl]-3-ethynylbenzenesulfonyl fluoride; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 98.0
- Lexical Diversity: 1.51724
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16228535', '16228546', '16228543', '13669610', '14250781']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8462057809666547
- 35 USC 102 Novelty (BERT): 0.6506379854982479
- Combined Prediction Score: 0.826649001419814
- Mean Citation Score: 558.2777060000002
- Max Citation Score: 658.6241
- Similarity Product: 580.7610279667377

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test