PATENT CLAIM ANALYSIS

Application Number: 15751316
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["564", "134000"]

Abstract:
The present invention relates to processes, process steps and intermediates useful in the asymmetric bisamidation of malonic ester derivatives wherein the new processes, process steps and intermediates are, for example, useful in the preparation of asymmetric malonic acid bisanilides such as cabozantinib.

Claim (Index 10):
A process for preparing an asymmetric malonic acid diamide of formula (IV) or a pharmaceutically acceptable salt thereof, the process comprising (i) reacting a compound of formula (III) \u2003or a compound of formula (III\u2032) \u2003or a mixture of the compound of formula (III) and the compound of formula (III\u2032) with an M b  salt of a compound H 2 N\u2014X 2 , obtaining a reaction mixture comprising an M b  salt of the compound of formula (IV); (ii) converting the M b  salt of the compound of formula (IV) to the compound of formula (IV); wherein R 1  and R 1 \u2032 are alkyl or aryl, and R 1  and R 1 \u2032 are the same or different; R 2  and R 3  are alkyl, alkoxy, aryl or heteroaryl and R 2  and R 3  are the same or different, or R 2  and R 3 , together with the C atom at which R 2  and R 3  are attached, form a cycle; X 1  is a substituted aromatic or heteroaromatic residue; X 2  is a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aromatic or heteroaromatic residue wherein X 1  is different from X 2 ; M b  is an alkali or alkaline earth metal.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 88.0
- Lexical Diversity: 1.46875
- Patent Class: 564.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14494631', '10994983', '12067612', '15750339', '15453953']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7103882752793983
- 35 USC 102 Novelty (BERT): 0.5142418836552668
- Combined Prediction Score: 0.6907736361169852
- Mean Citation Score: 227.855124
- Max Citation Score: 238.50386
- Similarity Product: 175.8737972288716

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test