PATENT CLAIM ANALYSIS

Application Number: 15911571
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["424", "181100"]

Abstract:
Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.

Claim (Index 1):
A method of making a compound of formula (IV): comprising the step of reacting a cytotoxic drug with a cross linker represented by formula (I): wherein:\n Y\u2032 represents a functional group that enables reaction with a cell-binding agent; \n Q represents a functional group that enables linkage of a cytotoxic drug via a disulfide, thioether, thioester, peptide, hydrazone, ether, ester, carbamate or amide bond; \n D represents a cytotoxic drug linked to the cell-binding agent by a disulfide, thioether, thioester, peptide, hydrazone, ester, ether, carbamate, or amide bond; \n one of R 1 , R 2 , R 3 , R 4 , R 9 , and R 10  is a charged substituent selected from SO 3 \u2212 , X\u2014SO 3 , OPO 3 2\u2212 , X\u2014OPO 3 2\u2212 , N + R 11 R 12 R 13  and X\u2014N + R 11 R 12 R 13 , and the rest are H; \n R 11 , R 12 , and R 13  are the same or different and are linear alkyl having from 1 to 6 carbon atoms, or branched or cyclic alkyl having from 3 to 6 carbon atoms and X represents phenyl or a linear alkyl having from 1 to 6 carbon atoms, or branched or cyclic alkyl having from 3 to 6 carbon atoms; \n l and m are each 0; \n n is 1; and \n Z is absent; or a polyethyleneoxy unit of formula (OCH 2 CH 2 ) p , wherein p is an integer from 2 to about 1000.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.42105
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13542126', '14080377', '14713419', '12433604', '15118726']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8303102628580349
- 35 USC 102 Novelty (BERT): 0.6292146506114723
- Combined Prediction Score: 0.8102007016333787
- Mean Citation Score: 621.5679200000002
- Max Citation Score: 675.3445
- Similarity Product: 534.8596378982961

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test