PATENT CLAIM ANALYSIS

Application Number: 16098308
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["514", "340000"]

Abstract:
The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Claim (Index 4):
A method of preparing a compound of general formula (I) according to  claim 1  said method comprising the step of\n [A] of allowing an intermediate compound of formula (II): \n in which R 1  is as defined for the compound of general formula (I) according to  claim 1 , R 3  represents a (C 1 -C 4 )-alkyl group, in particular a methyl group, to react in a first step in the presence of a base, and optionally a copper salt, with a compound of general formula (III): in which R 4  represents a (C 1 -C 4 )-alkyl group, in particular a methyl group, to give an intermediate compound, which is then allowed to react in the presence of a base in a second step with a hydrazine compound of general formula (IV) or a respective salt thereof in which Ar is as defined for the compound of general formula (I) according to  claim 1 , thereby giving a compound of general formula (V): in which R 1  and Ar are as defined for the compound of general formula (I) according to  claim 1 , and R 4  represents a (C 1 -C 4 )-alkyl group, in particular a methyl group, followed by a subsequent step [B] of allowing the compound of formula (V) obtained in step [A] to react with ammonia thereby giving a compound of general formula (I): in which R 1  and Ar are as defined for the compound of general formula (I) according to  claim 1 , optionally followed by step [C] conversion of the alcohols of general formula (I-A): in which Ar is as defined for the compound of general formula (I) according to  claim 1 , to the ketones of general formula (I-B): in which Ar is as defined for the compound of general formula (I) according to  claim 1 , using known oxidation methods, each [A], [B] and [C] optionally followed, where appropriate, by (i) separating the compounds of formula (I) thus obtained into their respective enantiomers, and/or (ii) converting the compounds of formula (I) into their respective hydrates, solvates, salts and/or hydrates or solvates of the salts by treatment with the corresponding solvents and/or acids or bases.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 98.0
- Lexical Diversity: 1.68571
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15581064', '16098255', '15969222', '16098202', '13819885']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7810759481812802
- 35 USC 102 Novelty (BERT): 0.6131212984855313
- Combined Prediction Score: 0.7642804832117054
- Mean Citation Score: 454.47792
- Max Citation Score: 537.7928
- Similarity Product: 505.7788174178123

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test