PATENT CLAIM ANALYSIS

Application Number: 16017157
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["800", "023000"]

Abstract:
The present invention provides methods and compostions to improve the efficiency of somatic cell nuclear transfer (SCNT) and the consequent production of nuclear transfer ESC (ntESC) and transgenic cells and/or non-human animals. More specifically, the present invention relates to the discovery that trimethylation of Histone H3-Lysine 9 (H3K9me3) in reprogramming resistant regions (RRRs) in the nuclear genetic material of donor somatic cells prevents efficient somatic cell nuclear reprogramming or SCNT. The present invention provide methods and compositions to decrease H3K9me3 in methods to improve efficacy of SCNT by exogenous or overexpression of the demethylase Kdm4 family and/or inhibiting methylation of H3K9me3 by inhibiting the histone methyltransferases Suv39h1 and/or Suv39h2.

Claim (Index 16):
The method of  claim 15 , wherein the non-human mammalian SCNT embryo is implanted into the non-human mammalian surrogate at any one of: a one-celled embryo stage, 2-celled embryo stage, four-celled embryo stage, morula stage, or blastocyst stage.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 94.0
- Lexical Diversity: 1.80597
- Patent Class: 800.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14276810', '12122557', '12528212', '14775594', '10865369']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.624308276606132
- 35 USC 102 Novelty (BERT): 0.5491856781166814
- Combined Prediction Score: 0.616796016757187
- Mean Citation Score: 354.94936399999995
- Max Citation Score: 431.14233
- Similarity Product: 316.3171681665624

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test