PATENT CLAIM ANALYSIS

Application Number: 15946634
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "256000"]

Abstract:
Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial infections, such as bacterial infections.

Claim (Index 1):
A compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the following formula: wherein\n X of Formula VI is O, S, SO, SO 2 , NR 11 , or CR 12 R 13 ; and \n R 1 -R 13  of Formula VI are independently absent or selected from hydrogen, ethyl, n-propyl, isopropyl, n-, sec-, iso-, or t-butyl, pentyl, hexyl, heptyl, substituted or unsubstituted cyclopentanyl; substituted or unsubstituted, linear, branched, or hetero alkenyl or alkynyl; substituted or unsubstituted aryl or heteroaryl; halogen; substituted or unsubstituted alkoxy; hydroxy, cyano, formyl, acyl, carboxylic acid, carboxylate, \u2014CONH 2 , \u2014CONHR 14 , \u2014CONR 14 R 14 , \u2014OCONHR 14 , \u2014NHCOOR 14 , \u2014OCONR 14 R 14 , \u2014NR 14 COOR 14 , NHCONHR 14 , \u2014NR 14 CONHR 14 , \u2014NHCONR 14 R 14 , \u2014NR 14 CONR 14 R 14 , \u2014CH 2 OH; \u2014CHR 14 OH, \u2014CR 14 R 14 OH, \u2014COOR 14 ), thiol, \u2014NH 2 , \u2014NHR 14 , \u2014NR 14 R 14 , \u2014SR 14 , \u2014SOR 14 , and \u2014SOOR 14 , wherein R 14  of Formula VI is defined the same as R 1 -R 13  of Formula VI; \n wherein\n X of Formula VII is O, S, SO, SO 2 , NR 9 , CR 10 R 11 ; and \n R 1 -R 11  of Formula VII are independently absent or selected from hydrogen, substituted or unsubstituted, linear, branched, hetero, or cyclic alkyl, alkenyl, or alkynyl; substituted or unsubstituted aryl or heteroaryl; halogen; substituted or unsubstituted alkoxy; hydroxy, cyano, formyl, acyl, carboxylic acid, carboxylate, \u2014CONH 2 , CONHR 12 , \u2014CONR 12 R 12 , \u2014OCONHR 12 , \u2014NHCOOR 12 , \u2014OCONR 12 R 12 , \u2014NR 14 COOR 12 , NHCONHR 12 , \u2014NR 12 CONHR 12 , \u2014NHCONR 12 R 12 , \u2014NR 14 CONR 12 R 12 , \u2014CH 2 OH, \u2014CHR 12 OH, \u2014CR 12 R 12 OH, \u2014COOR 12 , thiol, \u2014NH 2 , \u2014NHR 12 , \u2014NR 12 R 12 , \u2014SR 12 , \u2014SOR 12 , and \u2014SOOR 12 , wherein R 12  of Formula VII is defined the same as R 1 -R 11  of Formula VII; and \n wherein the compound of Formula VII is not Rose Bengal; \n wherein\n A and B of Formula I are independently S, SO 2 , SO, O, NR 6 , or CR 7 R 8 ; \n W and Z of Formula I are independently N or CR 9 ; \n X and Y of Formula I are independently S, O, or CR 10 R 11 ; and \n R 1 -R 11  of Formula I are independently absent or selected from hydrogen, substituted or unsubstituted, linear, branched, hetero, or cyclic alkyl, alkenyl, or alkynyl; substituted or unsubstituted aryl or heteroaryl; halogen, substituted or unsubstituted alkoxy; hydroxy, cyano, formyl, acyl, carboxylic acid, carboxylate, \u2014CONH 2 , \u2014CONHR 12 , \u2014CONR 12 R 12 , \u2014OCONHR 12 , \u2014NHCOOR 12 , \u2014OCONR 12 R 12 , \u2014NR 12 COOR 12 , NHCONHR 12 , \u2014NR 12 CONHR 12 , \u2014NHCONR 12 R 12 , \u2014NR 12 CONR 12 R 12 , \u2014CH 2 OH, \u2014CHR 12 OH, \u2014CR 12 R 12 OH, \u2014COOR 12 , thiol, \u2014NH 2 , \u2014NHR 12 , \u2014NR 12 R 12 , \u2014SR 12 , \u2014SOR 12 , and \u2014SOOR 12 , wherein R 12  of Formula I is defined the same as R 1 -R 11  of Formula I; \n wherein\n X of Formula II is S, SO, SO 2 , NHR 4 , O, or CR 5 R 6 ; \n Y of Formula II is N or CR 7 ; \n Z of Formula II is S, O, NR 8 , or CR 9 R 10 ; and \n R 1 -R 10  of Formula II is independently absent or selected from hydrogen, substituted or unsubstituted, linear, branched, hetero, or cyclic alkyl, alkenyl, or alkynyl; substituted or unsubstituted aryl or heteroaryl; halogen; substituted or unsubstituted alkoxy; hydroxy, cyano, formyl, acyl, carboxylic acid, carboxylate, \u2014CONH 2 , \u2014CONHR 11 , \u2014CONR 11 R 11 , \u2014OCONHR 11 , \u2014NHCOOR 11 , \u2014OCONR 11 R 11 , \u2014NR 11 COOR 11 , NHCONHR 11 , \u2014NR 10 CONHR 11 , \u2014NHCONR 11 R 11 , \u2014NR 11 CONR 11 R 11 , \u2014CH 2 OH, \u2014CHR 11 OH, \u2014CR 11 R 11 OH, \u2014COOR 11 , thiol, \u2014NH 2 , \u2014NHR 11 , \u2014NR 11 R 11 , \u2014SR 11 , \u2014SOR 11 , and \u2014SOOR 11 , wherein R 11  of Formula II is defined the same as R 1 -R 10  of Formula II; \n wherein\n X of Formula IV is O, S, NR 10 , or CR 11 R 12 ; \n R 1 -R 12  of Formula IV are independently absent or selected from hydrogen, substituted or unsubstituted, linear, branched, hetero, or cyclic alkyl, alkenyl, or alkynyl; substituted or unsubstituted aryl or heteroaryl; halogen; substituted or unsubstituted alkoxy; hydroxy, cyano, formyl, acyl, carboxylic acid, carboxylate, \u2014CONH 2 , \u2014CONHR 13 , \u2014CONR 13 R 13 , \u2014OCONHR 13 , \u2014NHCOOR 13 , \u2014OCONR 13 R 13 , \u2014NR 14 COOR 13 , NHCONHR 13 , \u2014NR 14 CONHR 13 , \u2014NHCONR 13 R 13 , \u2014NR 17 CONR 13 R 13 , \u2014CH 2 OH, \u2014CHR 13 OH, \u2014CR 13 R 13 OH, \u2014COOR 13 , thiol, \u2014NH 2 , \u2014NHR 13 , \u2014NR 13 R 13 , \u2014SR 13 , \u2014SOR 13 , and \u2014SOOR 13 , wherein R 13  of Formula IV is defined the same as R 1 -R 12  of Formula IV; and \n the dotted lines represent optional double bonds; \n wherein\n X and Y of Formula V are independently O, S, NR 13 , or CR 14 R 15 ; and \n R 1 -R 15  of Formula V are independently absent or selected from hydrogen, substituted or unsubstituted, linear, branched, hetero, or cyclic alkyl, alkenyl, or alkynyl; substituted or unsubstituted aryl or heteroaryl; halogen; substituted or unsubstituted alkoxy; hydroxy, cyano, formyl, acyl, carboxylic acid, carboxylate, \u2014CONH 2 , \u2014CONHR 16 , \u2014CONR 16 R 16 , \u2014OCONHR 16 , \u2014NHCOOR 16 , \u2014OCONR 16 R 16 , \u2014NR 16 COOR 16 , NHCONHR 16 , \u2014NR 16 CONHR 16 , \u2014NHCONR 16 R 16 , \u2014NR 16 CONR 16 R 16 , \u2014CH 2 OH, \u2014CHR 16 OH, \u2014CR 16 R 16 OH, \u2014COOR 16 , thiol, \u2014NH 2 , \u2014NHR 16 , \u2014NR 16 R 16 , \u2014SR 16 , \u2014SOR 16 , and \u2014SOOR 16 , wherein R 16  of Formula V is defined the same as R 1 -R 15  of Formula V; \n wherein\n Z of Formula VIII is O, S, SO, SO 2 , NR 6 , or CR 7 R 8 ; \n X and Y of Formula VIII are independently N, NR 9 , or CR 10 R 11 ; \n R 1 -R 11  of Formula VIII are independently absent or selected from hydrogen, substituted or unsubstituted, linear, branched, hetero, or cyclic alkyl, alkenyl, or alkynyl; substituted or unsubstituted aryl or heteroaryl; halogen; substituted or unsubstituted alkoxy; hydroxy, cyano, formyl, acyl, carboxylic acid, carboxylate, \u2014CONH 2 , \u2014CONHR 12 , \u2014CONR 12 R 12 , \u2014OCONHR 12 , \u2014NHCOOR 12 , \u2014OCONR 12 R 12 , \u2014NR 14 COOR 12 , NHCONHR 12 , \u2014NR 12 CONHR 12 , \u2014NHCONR 12 R 12 , \u2014NR 14 CONR 12 R 12 , \u2014CH 2 OH, \u2014CHR 12 OH, \u2014CR 12 R 12 OH, \u2014COOR 12 , thiol, \u2014NH 2 , \u2014NHR 12 , \u2014NR 12 R 12 , \u2014SR 12 , \u2014SOR 12 , and \u2014SOOR 12 , wherein R 12  of Formula VIII is defined the same as R 1 -R 11  of Formula VIII; and \n the dotted lines represent optional double bonds; or \n wherein\n Z of Formulas IX and IXa is O, S, SO, SO 2 , NR 7 , or CR 8 R 9 ; \n X and Y of Formulas IX and IXa are independently N, NR 10 , or CR 11 R 12 ; \n R 1 -R 12  of Formulas IX and IXa are independently absent or selected from hydrogen, substituted or unsubstituted, linear, branched, hetero, or cyclic alkyl, alkenyl, or alkynyl; substituted or unsubstituted aryl or heteroaryl; halogen; substituted or unsubstituted alkoxy; hydroxy, cyano, formyl, acyl, carboxylic acid, carboxylate, \u2014CONH 2 , \u2014CONHR 13 , \u2014CONR 13 R 13 , \u2014OCONHR 13 , \u2014NHCOOR 13 , \u2014OCONR 13 R 13 , \u2014NR 13 COOR 13 , NHCONHR 13 , \u2014NR 13 CONHR 13 , \u2014NHCONR 13 R 13 , \u2014NR 13 CONR 13 R 13 , \u2014CH 2 OH, \u2014CHR 13 OH, \u2014CR 13 R 13 OH, \u2014COOR 13 , thiol, \u2014NH 2 , \u2014NHR 13 , \u2014NR 13 R 13 , \u2014SR 13 , \u2014SOR 13 , and \u2014SOOR 13 , wherein R 13  of Formulas IX and IXa is defined the same as R 1 -R 12  of Formulas IX and IXa.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 91.0
- Lexical Diversity: 1.2963
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14406085', '10536899', '15222734', '15135334', '15620761']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7640719151430482
- 35 USC 102 Novelty (BERT): 0.553102060508699
- Combined Prediction Score: 0.7429749296796133
- Mean Citation Score: 247.46465
- Max Citation Score: 416.0576
- Similarity Product: 333.7326231758118

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test