PATENT CLAIM ANALYSIS

Application Number: 15985479
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["424", "450000"]

Abstract:
A temsirolimus liposome and preparation method thereof is provided. The formulation of the present invention contains temsirolimus, a phospholipid, a PEGylated phospholipid, and can further contain cholesterol, a stabilizer and a lyoprotectant. In view of the unique physicochemical properties of temsirolimus, the present invention performed a matching study on the formulation composition and preparation process, and developed a temsirolimus liposome, preferably a lyophilized powder injection, which is safe, stable in quality, simple in preparation process, and can be industrially produced. The preparation overcomes the disadvantages of poor safety, stability and the like in the existing preparations, establishing a solid foundation for the further study and application of temsirolimus in the anti-tumor field.

Claim (Index 5):
The temsirolimus liposome composition according to  claim 1 , characterized in that, the PEGylated phospholipid is selected from 1,2-distearoyl-sn-glycero-\u03b2-phosphoethanolamine-N-[methoxy(polyethylene glycol)] (DSPE-PEG) and/or dipalmitoyl phosphoethanolamine-PEG (DPPE-PEG), preferably 1,2-distearoyl-sn-glycero-\u03b2-phosphoethanolamine-N-[methoxy(polyethylene glycol)] (DSPE-PEG); wherein the molecular weight of polyethylene glycol is selected from 1000-8000, preferably 2000-5000.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 93.0
- Lexical Diversity: 1.92537
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15138527', '13819407', '10398222', '15300688', '14653234']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7470183314575328
- 35 USC 102 Novelty (BERT): 0.4932140189016276
- Combined Prediction Score: 0.7216379002019423
- Mean Citation Score: 227.909042
- Max Citation Score: 236.55312
- Similarity Product: 180.26701887076385

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test