PATENT CLAIM ANALYSIS

Application Number: 15749951
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "171000"]

Abstract:
The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent. The matrix forming agent forms a gel at a suitable gelation temperature and rheological properties for use in drug delivery, and in some cases, the gelation temperature and rheological properties are not significantly changed from those of the composition without the permeation enhancer. The invention also provides a matrix forming agent and compositions thereof. Such compositions are particularly useful in the treatment of otitis media. Methods of treatment, methods of delivery, and kits for the compositions described herein are also provided.

Claim (Index 1):
A composition comprising:\n (a) a therapeutic agent or a combination of therapeutic agents; (b) a permeation enhancer or a combination of permeation enhancers, wherein the permeation enhancer or combination of permeation enhancers increases the flux of the therapeutic agent or combination of therapeutic agents across a barrier; and (c) a matrix forming agent or a combination of matrix forming agents, wherein the matrix forming agent or combination of matrix forming agents comprises a polymer; wherein: the composition forms a gel at temperatures above a phase transition temperature; and the phase transition temperature is less than about 37\u00b0 C.; and at least one of conditions (i), (ii), and (iii) are met: (i) the phase transition temperature of the composition is less than the phase transition temperature of a reference composition plus about 5\u00b0 C.; (ii) the storage modulus of the composition is greater than about 15% of the storage modulus of the reference composition or greater than about 500 Pa, whichever is smaller, at a temperature of about 37\u00b0 C.; and (iii) the loss modulus of the composition is between about 15% and about 150% of the loss modulus of the reference composition at a temperature of about 37\u00b0 C.; wherein the reference composition is the composition in the absence of the permeation enhancer or combination of permeation enhancers.

Metadata:
- Claim Count in Document: 43.0
- Percentile: 88.0
- Lexical Diversity: 2.10145
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12993358', '10224173', '11899172', '14795819', '11547898']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7431821910840435
- 35 USC 102 Novelty (BERT): 0.5196448506951438
- Combined Prediction Score: 0.7208284570451535
- Mean Citation Score: 211.810478
- Max Citation Score: 302.94693
- Similarity Product: 193.9263522458929

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test