PATENT CLAIM ANALYSIS

Application Number: 16010822
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "064000"]

Abstract:
Novel CUR- and CUR-BF 2  compounds exhibiting anti-tumor properties are presented. CUR compounds bearing fluorinated moieties with selective fluorine introduction into the α-carbonyl moiety as well as CUR-BF 2  adducts and CURs with diverse substitution patterns in the phenyl rings including fluorinated substituents (SCF 3 , OCF 3 , and F) and/or bulky activating groups (OMe, OAc, and OBz) are presented. Fluorinated aryl-pyrazoles and isoxazoles as well as novel CUR and CUR-BF 2  compounds with monocyclic aromatic and bicyclic-heteroaromatic lateral rings, bearing fluorine(s), OCF3, CF3, and SCF3 groups, and their alpha-carbonyl-fluorinated analogs, as well as their pyrazole and isoxazole derivatives are presented. The CUR-pyrazoles embody analogs that are fluorinated at the phenyl-pyrazole moiety. The compounds and their derivatives exhibited exceptional cytotoxic and anti-proliferative activity against several cancer cell-lines. Deuterated CUR-BF2 and CUR compounds were also synthesized.

Claim (Index 8):
A method of treating a cancer in a patient, comprising:\n identifying a cancer or cancerous growth; administering a therapeutically effective amount of a composition comprising formula (I) or (II) to the patient: where * is a double bond or a single bond;\n wherein * is a double bond when at least one of R 6  and R 7  is unsubstituted or a single bond when R 6  is fluorine or hydrogen and R 7  is fluorine; \n where   is a double bond or a single bond;\n wherein   is a double bond when* is a single bond; \n where R 1  is o-OCH 3 , m-OCH 3 , o-F, H; where R 2  is o-OCH 3 , m-OCH 3 , H, m-OCF 3 , at a meta position, where R 3  is p-F, p-OCH 3 , m-CF 3 , p-CF 3 , p-SCF 3 , p-OH, at a para position, at a para position,\n where R 4  is O, a pyrazole formed with R 5 , O associated with a difluorobromide adduct, \n where R 5  is OH, O associated with a difluorobromide adduct, where R 6  is H, F, or unsubstituted forming a double bond at   ; where R 7  is H, or F; where R 8  is where R 9  is where R 10  is H, phenyl, 4-benzonitrile, and\n where R 11  is SCN.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 1.78409
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14512059', '13397195', '14849270', '14397842', '14035453']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7491838578650662
- 35 USC 102 Novelty (BERT): 0.5067795940024343
- Combined Prediction Score: 0.7249434314788031
- Mean Citation Score: 240.244364
- Max Citation Score: 248.71762
- Similarity Product: 161.13088904068948

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test