PATENT CLAIM ANALYSIS

Application Number: 15769754
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-01
Patent Classification: ["514", "210160"]

Abstract:
The present invention relates to oxa-diazaspiro compounds having pharmacological activity towards the sigma (σ) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

Claim (Index 18):
A compound of general Formula (I): wherein R 1  is m is 1, 2, 3, 4 or 5; n is 0, 1, 2, 3, 4 or 5; p is 0 or 1; q is 0, 1 or 2; r is 0, 1 or 2; X is a bond, \u2014C(R x R x\u2032 )\u2014, \u2014C(O)\u2014, \u2014O\u2014, \u2014C(O)NR 7 \u2014, \u2014NR 7 C(O)\u2014 or \u2014C(O)O\u2014;\n wherein R x  is selected from the group consisting of halogen or substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl substituted or unsubstituted C 2-6  alkynyl, and \u2014OR 7 ; \n R x\u2032  is selected from the group consisting of hydrogen, halogen or substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl and substituted or unsubstituted C 2-6  alkynyl; \n R 7  is selected from the group consisting of hydrogen, substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl and substituted or unsubstituted C 2-6  alkynyl; \n Y is \u2014CH 2 \u2014 or \u2014C(O)\u2014; R 1\u2032  is selected from the group consisting of substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl, substituted or unsubstituted C 2-6  alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl; R 2  is selected from the group consisting of hydrogen, substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl, substituted or unsubstituted C 2-6  alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl, R 3  is selected from the group consisting of substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl and substituted or unsubstituted C 2-6  alkynyl; R 3\u2032  is selected from the group consisting of hydrogen, substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl and substituted or unsubstituted C 2-6  alkynyl; or R 3  and R 3\u2032 , together with the carbon atom to which they are attached, form a substituted or unsubstituted cycloalkyl; R 4  and R 4\u2032  are independently selected from the group consisting of hydrogen, substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl, substituted or unsubstituted C 2-6  alkynyl, \u2014CHOR 9  and \u2014C(O)OR 9 ;\n wherein R 9  is selected from the group consisting of hydrogen, substituted or unsubstituted C 1-9  alkyl, substituted or unsubstituted C 2-9  alkenyl and substituted or unsubstituted C 2-9  alkynyl; \n R 5  and R 5\u2032  are independently selected from the group consisting of hydrogen, substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl, substituted or unsubstituted C 2-6  alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, \u2014CHOR 8  and \u2014C(O)OR 8 ; wherein R 8  is selected from hydrogen, substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl and substituted or unsubstituted C 2-6  alkynyl; or R 5  and R 5\u2032 , together with the carbon atom to which they are attached, form a substituted or unsubstituted cycloalkyl or a substituted or unsubstituted heterocyclyl; R 6  and R 6\u2032  are independently selected from the group consisting of hydrogen, substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl, substituted or unsubstituted C 2-6  alkynyl, \u2014CHOR 10  and \u2014C(O)OR 10 ;\n wherein R 10  is selected from the group consisting of hydrogen, substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl and substituted or unsubstituted C 2-6  alkynyl; \n optionally as a stereoisomer, including enantiomers and diastereomers, a racemate or a mixture of at least two stereoisomers, including enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof; with the following provisos applying:\n q is not 1 when r is 1; \n when Y is \u2014C(O)\u2014, then R 1  is not

Metadata:
- Claim Count in Document: 29.0
- Percentile: 91.0
- Lexical Diversity: 1.30556
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15769502', '15769520', '15315486', '15315095', '15569939']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.827997144592147
- 35 USC 102 Novelty (BERT): 0.5862540413652846
- Combined Prediction Score: 0.8038228342694609
- Mean Citation Score: 443.37464400000016
- Max Citation Score: 477.3474
- Similarity Product: 450.5651897453785

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test