PATENT CLAIM ANALYSIS

Application Number: 15752060
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "006110"]

Abstract:
The present invention relates to a method, in particular an in vitro method, for identifying monocytes, comprising analyzing the methylation status of at least one CpG position in the mammalian gene region for parkin RBR E3 ubiquitin protein ligase (PARK2), wherein a de-methylation or lack of methylation of said gene region is indicative for a monocyte, when compared to a non-monocyte cell. The analyses according to the invention can identify monocytes on an epigenetic level and distinguish them from all other cells in complex samples, such as, for example, other blood or immune cells. The present invention furthermore provides an improved method for quantifying monocytes, in particular in complex samples. The method can be performed without a step of purifying and/or enriching cells, preferably in whole blood and/or non-trypsinized tissue. Also claimed are kits and specific oligonucleotides for use as primers or probes.

Claim (Index 6):
The method according to  claim 1 , wherein said sample is selected from blood samples, or a tissue, organ or cell or a fraction thereof.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 88.0
- Lexical Diversity: 1.66667
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14443223', '14353671', '15661432', '13636556', '14771496']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6485705824997033
- 35 USC 102 Novelty (BERT): 0.522156326197129
- Combined Prediction Score: 0.6359291568694458
- Mean Citation Score: 287.894852
- Max Citation Score: 337.62347
- Similarity Product: 255.2771053128189

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test