PATENT CLAIM ANALYSIS

Application Number: 16003598
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["424", "194100"]

Abstract:
The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease. In particular, the methods encompass techniques for improved diagnosis and/or treatment of an ASM disorder, for example using enzyme replacement therapy.

Claim (Index 16):
A method of treating Niemann-Pick Disease type A or type B in a human subject, wherein the method comprises:\n administering to the subject intravenously a starting dose of recombinant human acid sphingomyelinase (rhASM) or a modified rhASM at 0.03 or 0.1 mg/kg and subsequent doses that increase in dose concentration until reaching 3 mg/kg; administering maintenance doses to the subject at 3 mg/kg or less; and measuring the level of lyso-sphingomyelin (lyso-SPM) in a biological sample collected from the subject (a) within 24 hours, (b) within 48 hours, or (c) 72 or more hours after administration of a dose; wherein each dose is administered two weeks after the previous dose.

Metadata:
- Claim Count in Document: 33.0
- Percentile: 94.0
- Lexical Diversity: 1.23077
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15485604', '14793838', '12870790', '14156894', '13679583']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7227880446219855
- 35 USC 102 Novelty (BERT): 0.5089393809396655
- Combined Prediction Score: 0.7014031782537535
- Mean Citation Score: 282.728848
- Max Citation Score: 285.02713
- Similarity Product: 242.14136902622343

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test