PATENT CLAIM ANALYSIS

Application Number: 16133322
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-08
Patent Classification: ["424", "451000"]

Abstract:
The present invention is directed to a System characterization of NASH that combines Modeling and Biomarkers, enabling pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and/or prevention of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH). Said conditions are Liver related complications among the array of manifestations of metabolic syndromes, including Type 2 diabetes, hyperlipidemia, weight gain, abdominal obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory states that lead to these manifestations, among others. In additional aspects, the present invention relates to compositions and methods which may be used to treat, inhibit or reduce the likelihood of NASH and NAFLD complications in patients with hepatitis viral infections, including Hepatitis B and Hepatitis C viral infections, as well as the secondary disease states and/or conditions which are often associated with such viral infections, including hepatic steatosis (steatohepatitis), cirrhosis, fatty liver and hepatocellular cancer, metabolic syndrome complications including cardiovascular diseases, neurodegenerative diseases and premature ageing, among other disease states or conditions.

Claim (Index 77):
The method of  claim 71  comprising determining a higher second wCombLiver signal, wCombBiopsy Predict signal, FS index and CV index relative to the first wCombLiver signal, wCombBiopsy Predict signal, FS index and CV index value, wherein the higher second value in said patient justifies the addition of a composition comprising an ileal brake hormone releasing substance to said patient, said ileal brake hormone releasing substance being released in the ileum of said patient which stimulates the release of ileal brake hormones and produces a GLP-1 Area under the curve or AUC value of approximately or at least an AUC value of 250.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 97.0
- Lexical Diversity: 1.78571
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14002642', '15162941', '15624275', '14677044', '13754855']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7233251475843951
- 35 USC 102 Novelty (BERT): 0.564972296429852
- Combined Prediction Score: 0.7074898624689409
- Mean Citation Score: 399.312976
- Max Citation Score: 502.13965
- Similarity Product: 304.17290099020903

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test