PATENT CLAIM ANALYSIS

Application Number: 15767842
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["530", "326000"]

Abstract:
The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. Previously, it has been demonstrated that superpositively charged proteins are efficiently endocytosed and can bring associated proteins and nucleic acids into cells. The vast majority of cargo delivered in this manner, however, remains in endosomes and does not reach the cytosol. The present invention provides endosomal escape peptides that enhance endosomal escape and cytosolic delivery of proteins and other agents of interest. In one aspect, described herein are novel fusion proteins comprising endosomal escape peptides fused to proteins and other agents of interest for delivery to a cell. Also provided herein are methods and compounds useful in preparing the fusion proteins, as well as pharmaceutical compositions and uses of the fusion proteins.

Claim (Index 12):
The protein of  claim 11 , wherein the protein is a supercharged protein, wherein the supercharged protein has an overall greater net charge than its corresponding wild-type protein.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 91.0
- Lexical Diversity: 1.72289
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15523325', '13318032', '14916679', '14462189', '14462163']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7158424248819477
- 35 USC 102 Novelty (BERT): 0.539071155472363
- Combined Prediction Score: 0.6981652979409892
- Mean Citation Score: 378.128936
- Max Citation Score: 429.6642
- Similarity Product: 234.98428752679823

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test