PATENT CLAIM ANALYSIS

Application Number: 15758274
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "233200"]

Abstract:
The present invention provides methods for inhibiting Fyn kinase, using 5-3-pyridin-2-amine, 6-3-imidazo[1,2-a] pyrazine, 6-3-imidazo[1,2-b] pyridazine, N-(5-imidazo [2,1-b][1,3,4] thiadiazol-2-yl)-amine, 4-3-1H-pyrazolo[3,4-b] pyridine, and N-(3-imidazo [1,2-b] pyridazin-6-yl) amine compounds and methods of treatment, prevention, inhibition or amelioration of diseases and conditions associated with Fyn kinase using such compounds.

Claim (Index 19):
A method for inhibiting activity of Fyn kinase in a patient, the method comprising administering a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt or solvate of the compound to a patient in need thereof, the compound selected from the group consisting of N-[3-[6-(2-furylmethylamino)pyrazin-2-yl]phenyl]acetamide, 4-[6-[1-(hydroxymethyl)propylamino]pyrazin-2-yl]phenol, 2-[[6-(5-isopropyl-2-methoxy-phenyl)pyrazin-2-yl]amino]butan-1-ol, 6-(3-aminophenyl)-N-benzyl-pyrazin-2-amine, 2-[[6-(4-aminophenyl)pyrazin-2-yl]amino]butan-1-ol, N-[3-(dimethylamino)propyl]-3-[6-(4-methoxyphenyl)pyrazin-2-yl]benzamide, 2-methoxy-4-[6-(4-methoxyphenyl)pyrazin-2-yl]phenol, N-[3-[6-(4-methoxyphenyl)pyrazin-2-yl]phenyl]acetamide, N-[3-[6-(3-hydroxyphenyl)pyrazin-2-yl]phenyl]acetamide, 3-[5-(3-furylmethylamino)-3-pyridyl]phenol, N-[3-[5-(3,4,5-trimethoxyanilino)-3-pyridyl]phenyl] acetamide, 3-[(3-methoxyphenyl)methyl]-5-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-b]pyrazin-2-one, N,N-dimethyl-3-[2-oxo-3-[(1 S)-1-phenylethyl]-1H-imidazo[4,5-b]pyrazin-5-yl]benzamide, 5-[3-(dimethylamino)phenyl]-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine, 3-[5-[(6-methoxy-3-pyridyl)amino]pyrazolo [1,5-a]pyrimidin-3-yl]phenol, 3-(3-methoxyphenyl)-N-(6-methoxy-3-pyridyl)pyrazolo [1,5-a]pyrimidin-5-amine, 1-[3-[5-[(6-methoxy-3-pyridyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl]phenyl]ethanone, N-[5-[[3-(3-hydroxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methyl-phenyl]methanesulfonamide, 3-(3,4-dimethoxyphenyl)-N-(3-pyridylmethyl)pyrazolo[1,5-a]pyrimidin-5-amine, N-(3-pyridylmethyl)-3-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-amine, N-(4-isopropylphenyl)-3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-amine, 3-(5-methoxy-3-pyridyl)-N-(4-morpholinophenyl)pyrazolo[1,5-a]pyrimidin-5-amine, 3-(3-aminophenyl)-N-(3-pyridylmethyl)pyrazolo [1,5-a]pyrimidin-5-amine, 3-(2-methoxyphenyl)-N-(3-pyridylmethyl)pyrazolo[1,5-a]pyrimidin-5-amine, (E)-3-[3-[5-(3-pyridylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]phenyl]prop-2-enoic acid, N-[3-(dimethylamino)propyl]-4-[6-(2-fluoro-3-methoxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide, 6-(1H-indol-5-yl)-N-methyl-pyrazin-2-amine, N-ethyl-2-(3,4,5-trimethoxyanilino)-7,8-dihydro-5H-pyrido [4,3-d]pyrimidine-6-carboxamide, 6-propyl-N-(3,4,5-trimethoxyphenyl)-7,8-dihydro-5H-pyrido [4,3-d]pyrimidin-2-amine, [2-[3-(dimethylamino)anilino]-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl]-(2-methoxyphenyl)methanone, N-[3-(4-fluorophenyl)-6-[4-(morpholine-4-carbonyl)phenyl]imidazo[1,2-a]pyridin-8-yl]formamide, N-[3-(3-acetylphenyl)-6-[4-(morpholine-4-carbonyl)phenyl]imidazo[1,2-a]pyridin-8-yl]formamide, N-[3-(3-chloro-4-fluoro-phenyl)-6-[3-(methanesulfonamido)phenyl]imidazo[1,2-a]pyridin-8-yl]formamide, N-[3-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-8-yl] formamide, 1-methyl-N-[4-(4-methylpiperazin-1-yl)phenyl]-2-[3-(trifluoromethyl)phenyl]pyrrolo[3,2-c]pyridin-6-amine, 1-methyl-N-pyrimidin-4-yl-2-[3-(trifluoromethyl)phenyl]pyrrolo[3,2-c]pyridin-6-amine, 2-(3-fluorophenyl)-1-methyl-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[3,2-c]pyridin-6-amine, 2-(3-fluorophenyl)-1-methyl-N-pyrimidin-4-yl-pyrrolo[3,2-c]pyridin-6-amine, 1-benzyl-N-[4-(4-methylpiperazin-1-yl)phenyl]-2-(3-pyridyl)pyrrolo[3,2-c]pyridin-6-amine, 2-(1H-pyrazol-4-yl)-N-(2-pyridyl)-1H-pyrrolo[3,2-c]pyridin-6-amine, N-(4-methylsulfonylphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine, 1-benzyl-2-(3-pyridyl)-N-pyrimidin-4-yl-pyrrolo[3,2-c]pyridin-6-amine, N-(3-methoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine, N-(3,4-dimethoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine, 1-benzyl-N-[4-(4-methylpiperazin-1-yl)phenyl]-2-phenyl-pyrrolo[3,2-c]pyridin-6-amine, N-[3-[8-acetamido-3-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-6-yl]phenyl] acetamide, N-[3-(3-acetylphenyl)-6-(3-methoxyphenyl)imidazo[1,2-a]pyridin-8-yl]acetamide, N-[3-(3-acetylphenyl)-6-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-8-yl] acetamide, N-[3-(3-acetylphenyl)-6-(2-methoxyphenyl)imidazo[1,2-a]pyridin-8-yl]acetamide, N-[6-(4-aminophenyl)-3-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]acetamide, N-[3-(3-acetylphenyl)-6-[4-(morpholine-4-carbonyl)phenyl] imidazo[1,2-a]pyridin-8-yl] acetamide, N,N-dimethyl-4-[4-[4-(4-methylpiperazin-1-yl)anilino]-1H-pyrrolo[3,2-c]pyridin-2-yl]benzamide, 4-[2-(3,5-dimethoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]morpholine, N-[4-[[2-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]amino]phenyl] acetamide, 2-(2-methoxyphenyl)-1-methyl-N-[3-(trifluoromethyl)phenyl]pyrrolo[3,2-c]pyridin-4-amine, 6-(3-chlorophenyl)-3-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-amine, 5-amino-4-(1H-benzimidazol-2-yl)-1-(1,3-benzodioxol-5-yl)-2H-pyrrol-3-one, 8-(2,5-dimethoxyphenyl)-7-(4-fluorophenyl)-1-methyl-3H-imidazo[1,2-g]purine-2,4-dione, methyl 2-amino-1-(3-hydroxyphenyl)pyrrolo[3,2-b] quinoxaline-3-carboxylate, 2-(3,4-dimethoxyphenyl)-6-hydroxy-chromen-4-one, 2-amino-1-(3-methoxyphenyl)pyrrolo[3,2-b] quinoxaline-3-carboxamide.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.6383
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13056331', '13057325', '12598882', '13049225', '14554714']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.791686866224509
- 35 USC 102 Novelty (BERT): 0.5338306283095854
- Combined Prediction Score: 0.7659012424330166
- Mean Citation Score: 353.30427799999984
- Max Citation Score: 374.5595
- Similarity Product: 232.71090832132103

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test