PATENT CLAIM ANALYSIS

Application Number: 16061084
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "410000"]

Abstract:
Disclosed is to a laevorotatory enantiomer of the configurational stereoisomer of difethialone, named hetero-stereoisomer, the formula of which is 3-(4′-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which carbons 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group have different absolute configurations.

Claim (Index 15):
Chromatographic process for obtaining a laevorotatory enantiomer of a configurational stereoisomer of difethialone, named hetero-stereoisomer, the formula of which is 3-(4\u2032-bromobiphenyl-4-yl)-1-(4-hydroxythiocoumarin-3-yl)-1,2,3,4-tetrahydronaphthalene, in which carbons 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group of said hetero-stereoisomer have different absolute configurations, in which process:\n a high-pressure liquid chromatography column of dimensions 150\u00d72 mm, and comprising a chiral stationary phase constituted of particles of tris(4-methylbenzoate) cellulose, said particles having a mean size of 3 \u03bcm and having a mean pore size of 1000 \u212b, is chosen; a mixture formed from acetonitrile (A) and water comprising 0.1% by volume of formic acid (B), with an A/B volume ratio of 80/20 and with a flow rate of the liquid mobile phase in the chromatography column of 0.25 mL/minute, is chosen as liquid mobile phase; separation of the configurational stereoisomers of difethialone is performed at room temperature, during which: a liquid composition comprising said laevorotatory enantiomer of said hetero-stereoisomer of difethialone is introduced into the top of the chromatography column; and then the liquid composition is entrained with the mobile phase in the chromatography column under conditions suitable for separating the configurational stereoisomers of difethialone; and a fraction of the mobile phase comprising said laevorotatory enantiomer of said hetero-stereoisomer of difethialone is collected with a retention time t 2  having a value such that t 1 <t 2 <t 3 <t 4 ; t 1 , t 3  and t 4  representing the retention times of each of the configurational stereoisomers of difethialone different from the laevorotatory enantiomer of said hetero-stereoisomer of difethialone, separately from a dextrorotatory enantiomer of said hetero-stereoisomer of difethialone with a retention time t 3  and separately from the laevorotatory and dextrorotatory enantiomers of a configurational stereoisomer of difethialone, named homo-stereoisomer, in which carbons 1 and 3 of the 1,2,3,4-tetrahydronaphthalene group of said homo-stereoisomer have the same absolute configuration, and of retention times t 1  and t 4 ; and then the liquid mobile phase of said fraction is removed so as to obtain said laevorotatory enantiomer of said hetero-stereoisomer of difethialone.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 94.0
- Lexical Diversity: 1.31429
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15735677', '16061115', '15318195', '15318123', '13579945']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7531876657531175
- 35 USC 102 Novelty (BERT): 0.6357970612887064
- Combined Prediction Score: 0.7414486053066763
- Mean Citation Score: 408.28747
- Max Citation Score: 732.9718
- Similarity Product: 535.1403781429292

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test