PATENT CLAIM ANALYSIS

Application Number: 15907480
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "006000"]

Abstract:
Provided herein are opto-genetic systems, cells, and methods thereof for modulating and regulating genetic expression in transiently active cells. The technologies described herein provide a transformative genetic regulatory tool for in vivo applications, which broadly spans a variety of disciplines, including behavioral, cognitive, and systems neuroscience.

Claim (Index 28):
A method of expressing a gene of interest in a neuron in an activation-specific manner, the method comprising:\n introducing a system of  claim 1  to a neuron, wherein the physiological response element comprises a downstream responsive element (DRE) that binds the downstream responsive element antagonist modulator (DREAM) repressor, and wherein intranuclear calcium binds the DREAM repressor and causes dissociation of the repressor from the DRE; and irradiating the neuron with light within the defined range of wavelengths, wherein the gene of interest is expressed in a neuronal activation-specific manner.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.38462
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15036020', '14105017', '12771457', '14004879', '11115922']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5945938458606171
- 35 USC 102 Novelty (BERT): 0.5100712287326522
- Combined Prediction Score: 0.5861415841478207
- Mean Citation Score: 255.01408
- Max Citation Score: 261.08667
- Similarity Product: 152.69795855050208

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test