PATENT CLAIM ANALYSIS

Application Number: 16004077
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["436", "501000"]

Abstract:
The present invention relates to a compound selectively binding to a sensory receptor or selectively altering the expression of a sensory receptor for use in a method for treating or preventing a disease associated with a pathologic cellular cytotoxic T cell (CTL) response. Further, the invention relates to means for detecting a sensory receptor for use in a method for diagnosing cellular resistance against CTL response in a patient. The invention further embraces a method for determining the resistance of a cell against a CTL response in vitro and to a method for identifying agents that influence the response of cells to CTLs.

Claim (Index 19):
The method according to  claim 16 , wherein the compound enhances an immune response to an activated CTL, in particular in a patient suffering from a neoplasia, in particular cancer, preferably\n wherein the local surface concentration and/or T cell-binding activity of the surface receptor that prevents CTL response is reduced; and/or wherein said compound is selected from the group consisting of:\n (i) a compound reducing the expression of a sensory receptor and/or of a polypeptide involved in cell signaling of a sensory receptor, preferably an interfering RNA, in particular a small interfering ribonucleic acid (siRNA) or a small hairpin RNA (shRNA), complementary to mRNA encoding for said sensory receptor, and \n (ii) a compound preventing the T cell-binding activity to said sensory receptor, in particular wherein said compound is an antibody or a sensory receptor-binding fragment.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 94.0
- Lexical Diversity: 2.01852
- Patent Class: 436.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14914585', '13819940', '13126039', '13321812', '15981142']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7075240309298718
- 35 USC 102 Novelty (BERT): 0.6042748921320419
- Combined Prediction Score: 0.6971991170500889
- Mean Citation Score: 353.8247340000001
- Max Citation Score: 727.0481599999997
- Similarity Product: 475.98571940660463

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test