PATENT CLAIM ANALYSIS

Application Number: 15771136
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "229800"]

Abstract:
The present invention provides a compound of Formula (I) and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds and said stereoisomers, and pharmaceutical compositions thereof, and methods for using said compounds and compositions for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

Claim (Index 1):
A compound of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n Y 1  is CR 3  or N; \n Y 2  is CR 3  or N; \n Y 3  is CR 3  or N; \n Y 4  is CR 3  or N, \n such that three of Y 1 , Y 2 , Y 3  and Y 4  are not simultaneously N, and all four of Y 1 , Y 2 , Y 3  and Y 4  are not simultaneously N; \n each R 3  is independently hydrogen, C 1-3  alkyl, C 3-6  cycloalkyl, halo, cyano or hydroxy, wherein said C 1-3  alkyl and said C 3-6  cycloalkyl groups are optionally independently substituted with one to three groups independently selected from halo or hydroxyl; \n U is a bond or NH; \n \u2014Z 1 \u2014X 1 \u2014 is selected from the group consisting of: \u2014C(O)O\u2014, \u2014C(O)CH 2 \u2014, \u2014C(O)NH\u2014, \u2014S(O) 2 O\u2014, \u2014S(O) 2 CH 2 \u2014, \u2014S(O) 2 NH\u2014, \u2014S(O)CH 2 \u2014, \u2014S(O)NH\u2014, \u2014C(O)\u2014, and \u2014S(O) 2 \u2014; \n n is 1, 2, or 3; \n {circle around (A)} is aryl or heteroaryl, each of which is optionally substituted with one to three groups independently selected from the group consisting of halo, cyano, R 6 , OR 6 , C(O)OR 6 , NR 6 R 7 , NHC(O)O(C 1 -C 6 )alkyl, NHC(O)OC 3-6 cycloalkyl, \u2014NHSO 2 (C 1 -C 6 )alkyl, CONR 7 R 8 , and \u2014CH 2 CONR 7 R 8 ; \n {circle around (B)} is aryl or heteroaryl, which is optionally substituted with one to three groups independently selected from the group consisting of halo, cyano, oxo, R 6 , OR 6 , C(O)OR 6 , C 1-3  alkyl-C(O)OR 6 , C(O)NR 6 R 7  and NR 6 R 7 ; \n \u2014Y\u2014X\u2014 is selected from the group consisting of \u2014C(O)\u2014NR 6 \u2014, \u2014CH(R 5 )C(O)\u2014NR 6 \u2014, \u2014CH(C(O)OR 7 )\u2014NR 6 \u2014, \u2014C(O)\u2014O\u2014, \u2014NR 6 \u2014C(O)\u2014, \u2014CH(C(O)N(R 6 R 7 ))\u2014NR 6 \u2014, \u2014CH(CR 6 R 7 OR 8 )\u2014NR 6 \u2014, \u2014CH(CR 6 R 7 NR 6 R 7 )\u2014NR 6 \u2014, \u2014OC(O)\u2014NR 6 \u2014, \u2014NR 6 \u2014C(O)O\u2014, \u2014NR 6 \u2014C(O)NR 6 \u2014, and \u2014S(O) 2 \u2014NR 6 \u2014; \n R 5  is fluoro or C 1-6  alkyl; \n Z is C 3-8  alkylene or C 3-8  alkenylene, wherein one of the carbon atoms in said alkylene and alkenylene, where chemically permitted, may be replaced with O, NR 6 , C(O), C(O)NR 6 , NR 6 C(O), S, SO or SO 2 ; \n each R 6  is independently hydrogen or C 1-6  alkyl, which is optionally substituted with one to three groups independently selected from the group consisting of halo, hydroxyl, (C 1 -C 3 )alkoxyl, C(O)OH, and C(O)O(C 1 -C 3 )alkyl; \n each R 7  is independently hydrogen, C 1-6  alkyl, heteroaryl or heterocyclyl, wherein said alkyl group is optionally substituted with one to three groups independently selected from the group consisting of halo and hydroxy; and \n each R 8  is independently hydrogen or C 1-6  alkyl.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.64286
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15771538', '15305421', '15116659', '15329635', '15329609']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8240603463803587
- 35 USC 102 Novelty (BERT): 0.5628116093569395
- Combined Prediction Score: 0.7979354726780168
- Mean Citation Score: 411.63498
- Max Citation Score: 453.12164
- Similarity Product: 332.06812111698633

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test