PATENT CLAIM ANALYSIS

Application Number: 16000382
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["544", "328000"]

Abstract:
The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3 -yl]pyrimidin-5 -yl methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3 -yl]pyrimidin-5 -yl methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.

Claim (Index 8):
A process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the Formula I: comprising:\n cleaving 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine of the Formula III: \n by catalytic hydrogenation to form 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4,5,6-pyrimidinetriamine of the Formula VIII: and isolating the 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4,5,6-pyrimidinetriamine of the Formula VIII so formed by precipitation from a C 1 -C 4  alcohol and/or water without intermediate formation of salts;\n reacting 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4,5,6-pyrimidinetriamine of the Formula VIII: \n in a pyridine-free process with\n (a) methyl chloroformate of the formula (V): \n or\n (b) dimethyl dicarbonate of the Formula X: \n to produce methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinylcarbamate of the Formula VI: and\n methylating methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinylcarbamate of the Formula VI by reacting with a methylating agent of the Formula Me-X to form crude methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the Formula I, wherein Me-X is selected from the group consisting of methyl iodide, dimethyl sulphate, and methyl toluenesulphonate.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 94.0
- Lexical Diversity: 2.14545
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13945639', '14295922', '12955510', '12955864', '13111856']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8015112618185734
- 35 USC 102 Novelty (BERT): 0.5699585017351948
- Combined Prediction Score: 0.7783559858102356
- Mean Citation Score: 420.89559800000006
- Max Citation Score: 470.64746
- Similarity Product: 408.6355672748757

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test