PATENT CLAIM ANALYSIS

Application Number: 16203108
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-09
Patent Classification: ["514", "081000"]

Abstract:
The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, compositions comprising the prodrugs, intermediates and methods for synthesizing the prodrugs and methods of using the prodrugs in a variety of applications.

Claim (Index 1):
A method of inhibiting the release and/or synthesis of cytokines in a cell, the method comprising contacting the cell with a metabolite of the compound of formula (I): or a salt, solvate, hydrate or N-oxide thereof, wherein:\n Y is O; \n Z 1  and Z 2  are each, independently of one another, CH or N; \n R 2  is lower alkyl, lower cycloalkyl, lower heteroalkyl, lower cycloheteroalkyl, aryl, or a heteroaryl group, each of which is optionally substituted; \n R 5  is halo, cyano, nitro, or trihalomethyl; \n R 17  is hydrogen, halogen, fluoro, or lower alkyl or, alternatively, R 17  taken together with R 18  are an oxo (\u2550O) group; \n R 18  is hydrogen, halogen, fluoro, or lower alkyl, or, alternatively, R 18  taken together with R 17  are an oxo (\u2550O) group; \n R 19  hydrogen or lower alkyl, or, alternatively, R 19  taken together with R 20  are an oxo (\u2550O) group; \n R 20  is hydrogen or lower alkyl, or, alternatively, R 20  taken together with R 19  are an oxo (\u2550O) group; \n R 21 , R 22  and R 23  are each, independently of one another, hydrogen or R P ; \n R 24  is hydrogen, lower alkyl or R P , with the proviso that at least one of R 21 , R 22 , R 23  and R 24  is R P ; and \n each R P  is, independently of the others, \u2014(CR d R d ) y \u2014O\u2014P(O)(OR i )(OR i ), \u2014(CR d R d ) y \u2014O\u2014P(O)(OR i )(OH), \u2014(CR d R d ) y \u2014O\u2014P(OR i )(OR i ) or \u2014(CR d R d ) y \u2014O\u2014P(OR i )(OH), where each R i  is, independently of the others, lower unsubstituted alkanyl, substituted or unsubstituted phenyl, or substituted or unsubstituted benzyl; \n each R d  is, independently of the other, hydrogen, cyano, optionally substituted (C 1 -C 20 ) alkyl, (C 1 -C 20 ) perfluoroalkyl, optionally substituted (C 7 -C 30 ) arylalkyl or optionally substituted 6-30 membered heteroarylalkyl, where each optional substituent is, independently of the others, selected from hydrogen, alkyl, aryl, arylalkyl, heteroaryl and heteroalkyl, or, alternatively, two R d  taken together with the carbon atom to which they are bonded are a (C 3 -C 5 ) cycloalkyl; and \n y is 1, 2, or 3, and \n wherein the metabolite is the product of cleavage of the R p  group from the compound of formula (I).

Metadata:
- Claim Count in Document: 62.0
- Percentile: 98.0
- Lexical Diversity: 1.4
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14310312', '14995027', '12268218', '11453731', '13909858']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.833357219729843
- 35 USC 102 Novelty (BERT): 0.6014660177352227
- Combined Prediction Score: 0.8101680995303809
- Mean Citation Score: 551.374864
- Max Citation Score: 559.08997
- Similarity Product: 452.9892430025274

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test