PATENT CLAIM ANALYSIS

Application Number: 16241177
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["514", "256000"]

Abstract:
The present invention relates to a novel heterocyclic compound inhibiting a cyclin-dependent kinase (CDK) and a pharmaceutical composition comprising the same as an effective ingredient. The heterocyclic compound according to the present invention or pharmaceutically acceptable salt thereof can be effectively used in treating or preventing cancers, degenerative brain diseases, etc.

Claim (Index 2):
The method according to  claim 1 , wherein the compound of formula (I) or a pharmaceutically acceptable salt thereof is selected from the group consisting of the following compounds:\n 2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol; 2\u2032-amino-6-(2-aminopyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2-(2-aminopyrimidin-4-yl)-6-(4-hydroxyphenyl)pyridin-3-ol; 2\u2032-amino-6-(2-aminopyrimidin-4-yl)-[2,4\u2032-bipyridin]-5-ol; 6-(2-aminopyrimidin-4-yl)-[2,3\u2032-bipyridin]-5-ol; 6-(2-aminopyrimidin-4-yl)-[2,4\u2032-bipyridin]-5-ol; 2-(2-aminopyrimidin-4-yl)-6-(3-hydroxyphenyl)pyridin-3-ol; 6-(2-aminopyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 6-(4-amino-2-fluorophenyl)-2-(2-aminopyrimidin-4-yl)pyridin-3-ol; 6-(3-aminophenyl)-2-(2-aminopyrimidin-4-yl)pyridin-3-ol; 2-(2-aminopyrimidin-4-yl)-6-(2-fluoro-4-hydroxyphenyl)pyridin-3-ol; 6-(3-amino-2-fluorophenyl)-2-(2-aminopyrimidin-4-yl)pyridin-3-ol; 2-(2-aminopyrimidin-4-yl)-6-(3-fluoro-4-hydroxyphenyl)pyridin-3-ol; 2-(2-aminopyrimidin-4-yl)-6-(2,3-difluoro-4-hydroxyphenyl)pyridin-3-ol; 2\u2032-amino-6-(2-aminopyrimidin-4-yl)-[2,4\u2032-bipyridin]-3\u2032,5-diol; 2\u2032-amino-6-(2-amino-6-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 6-(2-amino-6-methylpyrimidin-4-yl)-[2,4\u2032-bipyridin]-5-ol; 6-(2-amino-6-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2-(2-amino-6-methylpyrimidin-4-yl)-6-(4-hydroxyphenyl)pyridin-3-ol; 2-(2-amino-6-methylpyrimidin-4-yl)-6-(2,3-difluoro-4-hydroxyphenyl)pyridin-3-ol; 2-(2-amino-6-methylpyrimidin-4-yl)-6-(2-fluoro-4-hydroxyphenyl)pyridin-3-ol; 2-(2-amino-6-methylpyrimidin-4-yl)-6-(3-aminophenyl)pyridin-3-ol; 2\u2032-amino-6-(2-amino-6-isopropylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(piperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-methylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-ethylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-propylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-methylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-ethylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-propylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5-methyl-6-(1-methylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-ethylpiperidin-4-yl)-5-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5-methyl-6-(1-propylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-4-yl)-5-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5-methyl-6-(1-methylpiperidin-3-yl)pyrimidin-3-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5-methyl-6-(1-propylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-3-yl)-5-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5-ethyl-6-(1-isopropylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-4-yl)-5-propylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-morpholinopyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(dimethylamino)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 6-(2-amino-6-chloropyrimidin-4-yl)-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5-ethylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5-propylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5-isopropylpyrimidin-5-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-3\u2032-fluoro-6-(2-(methylamino)-6-(1-methylpiperidin-4-yl)pyrimidin-4-yl)-[2,4\u2032-bipyridin]-5-ol; 2\u2032-amino-6-(2-amino-5,6-dimethylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol; 2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol 3hydrochloride; 2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol oxalate; 2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol malonate; 2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol sulfate; 2\u2032-amino-4-(2-aminopyrimidin-4-yl)-[2,4\u2032-bipyridin]-5-ol oxalate; 2\u2032-amino-6-(2-aminopyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 3hydrochloride; 2\u2032-amino-6-(2-aminopyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol acetate; 2\u2032-amino-6-(2-aminopyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol oxalate; 2\u2032-amino-6-(2-aminopyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 2malonate; 2-(2-aminopyrimidin-4-yl)-6-(2-fluoro-4-hydroxyphenyl)pyridin-3-ol 2hydrochloride; 2\u2032-amino-6-(2-amino-6-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 3hydrochloride; 2\u2032-amino-6-(2-amino-6-morpholinopyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-morpholinopyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol acetate; 2\u2032-amino-6-(2-amino-6-(dimethylamino)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 5hydrochloride; 2\u2032-amino-6-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol acetate; 2\u2032-amino-6-(2-amino-(6-(1-methylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-methylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 2acetate; 2\u2032-amino-6-(2-amino-6-(1-methylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol oxalate; 2\u2032-amino-6-(2-amino-6-(1-methylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol malonate; 2\u2032-amino-6-(2-amino-6-isopropylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 3hydrochloride; 2\u2032-amino-6-(2-amino-6-isopropylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 2acetate; 2\u2032-amino-6-(2-amino-6-(piperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(piperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol acetate; 2\u2032-amino-6-(2-amino-6-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 3hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-ethylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-propylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-methylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-ethylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-propylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-5-methyl-6-(1-methylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-ethylpiperidin-4-yl)-5-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-5-methyl-6-(1-propylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-4-yl)-5-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-5-methyl-6-(1-methylpiperidin-3-yl)pyrimidin-3-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-5-methyl-6-(1-propylpiperidin-3-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-3-yl)-5-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; 2\u2032-amino-6-(2-amino-5-methylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 3hydrochloride; 2\u2032-amino-6-(2-amino-5,6-dimethylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 3hydrochloride; 2\u2032-amino-6-(2-amino-5-ethylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 3hydrochloride; 2\u2032-amino-6-(2-amino-5-propylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 3hydrochloride; 2\u2032-amino-6-(2-amino-5-isopropylpyrimidin-5-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 3hydrochloride; 2\u2032-amino-6-(2-amino-5-ethyl-6-(1-isopropylpiperidin-4-yl)pyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride; and 2\u2032-amino-6-(2-amino-6-(1-isopropylpiperidin-4-yl)-5-propylpyrimidin-4-yl)-3\u2032-fluoro-[2,4\u2032-bipyridin]-5-ol 4hydrochloride.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 99.0
- Lexical Diversity: 1.26667
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15546714', '12992027', '12865339', '14235477', '14435473']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7778704760096723
- 35 USC 102 Novelty (BERT): 0.6631995390736272
- Combined Prediction Score: 0.7664033823160677
- Mean Citation Score: 385.610898
- Max Citation Score: 642.3304400000002
- Similarity Product: 619.3589899489832

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test