PATENT CLAIM ANALYSIS

Application Number: 16000108
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "412000"]

Abstract:
The present invention provides compounds that modulate protein function, specifically phosphodiesterase 4 (PDE4). The invention provides methods of treating, ameliorating, and/or preventing diseases, disorders, and conditions associated with PDE4. Compositions, including in combination with other inflammatory mediators, are also provided.

Claim (Index 2):
The compound of Formula (I) or Formula (II) of  claim 1 , or a pharmaceutically acceptable salt of any of the foregoing, wherein: Y is H, deuterium, halogen, or an optionally substituted C 1 -C 6  alkyl; X and X 1  are each independently CH 2 , C\u2550O, SO, SO 2 , or CH 2 CO; R 1  is H, deuterium, hydroxy, halogen, nitro, cyano, optionally substituted C 1 -C 6  alkoxy, \u2014NH 2 , \u2014NHR 1A , \u2014NR 1A R 1B , \u2014NHC(O)R 1C , \u2014NR 1A C(O)R 1C , \u2014NHSO 2 R 1C , \u2014NR 1A SO 2 R 1C , an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 3 -C 6  cycloalkyl, an optionally substituted 3 to 10 membered heterocyclyl, an optionally substituted C 6 -C 10  aryl, or an optionally substituted 5 to 10 membered heteroaryl; R 1A , R 1B , and R 1C  are independently selected from an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 3 -C 6  cycloalkyl, an optionally substituted 3 to 10 membered heterocyclyl, an optionally substituted C 6 -C 10  aryl, or an optionally substituted 5 to 10 membered heteroaryl; R 2  is hydroxy, \u2014NH 2 , \u2014NHR 1A , \u2014NR 1A R 1B , an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 3 -C 6  cycloalkyl, an optionally substituted 3 to 10 membered heterocyclyl, an optionally substituted C 6 -C 10  aryl, or an optionally substituted 5 to 10 membered heteroaryl; R 3 , R 6 , and R 7  are independently selected from a hydrogen, a deuterium, a halogen, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 1 -C 6  alkoxy, an optionally substituted C 3 -C 6  cycloalkyl, an optionally substituted 3 to 10 membered heterocyclyl, an optionally substituted C 6 -C 10  aryl, and an optionally substituted 5 to 10 membered heteroaryl; R 4  and R 5  are independently selected from an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 3 -C 6  cycloalkyl, an optionally substituted 3 to 10 membered heterocyclyl, an optionally substituted C 6 -C 10  aryl, and an optionally substituted 5 to 10 membered heteroaryl; or R 4  and R 5 , together with the atoms to which they are attached, form an optionally substituted 5 or 6 membered heterocyclyl; when R 2  is an optionally substituted C 1 -C 4  alkyl or NH(C 1 -C 6  alkyl), at least one of R 4  and R 5  is an optionally substituted cyclopropyl, an optionally substituted 3 to 10 membered heterocyclyl, an optionally substituted C 6 -C 10  aryl, an optionally substituted 5 to 10 membered heteroaryl, or R 4  and R 5 , together with the atoms to which they are attached, form an optionally substituted 5 or 6 membered heterocyclyl; wherein, when a C 1 -C 6  alkyl, a C 1 -C 6  alkoxy, a C 3 -C 6  cycloalkyl, a C 6 -C 10  aryl, a 3 to 10 membered heterocyclyl, or a 5 to 10 membered heteroaryl is substituted, the substituted substituents are independently selected from a deuterium, an oxo, a halogen, cyano, a nitro, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 1 -C 6  haloalkyl, an optionally substituted C 1 -C 6  alkoxy, an optionally substituted C 3 -C 6  cycloalkyl, an optionally substituted C 6 -C 10  aryl, an optionally substituted 3 to 10 membered heterocyclyl, an optionally substituted 5 to 10 membered heteroaryl, \u2014C(O)R A , \u2014C(O)OR A , \u2014C(O)NR B R C , \u2014OR A , \u2014OC(O)R A , \u2014OC(O)NR B R C , \u2014OS(O)R A , \u2014OS(O) 2 R A , \u2014OS(O)NR B R C , \u2014OS(O) 2 NR B R C , \u2014NR B R C , \u2014NR A C(O)R A , \u2014NR A C(O)OR A , \u2014NR A C(O)NR B R C , \u2014NR A S(O)R A , \u2014NR A S(O) 2 R A , \u2014NR A S(O)NR B R C , \u2014NR A S(O) 2 NR B R C , \u2014SR A , \u2014S(O)R A , \u2014S(O) 2 R A , \u2014S(O)NR B R C , and \u2014S(O) 2 NR B R C ; and each R A , R B , and R C  are independently selected from a hydrogen, a deuterium, an unsubstituted C 1 -C 6  alkyl, an unsubstituted C 2 -C 6  alkenyl, an unsubstituted C 3 -C 6  cycloalkyl, an unsubstituted 3 to 10 membered heterocyclyl, an unsubstituted C 6 -C 10  aryl, and an unsubstituted 5 to 10 membered heteroaryl; or R B  and R C , together with the nitrogen atom to which they are attached, form an optionally substituted 3 to 10 membered heterocyclyl.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 94.0
- Lexical Diversity: 1.33333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12657801', '13830486', '14574007', '14552226', '13830712']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8043111346534728
- 35 USC 102 Novelty (BERT): 0.5149469151106615
- Combined Prediction Score: 0.7753747126991917
- Mean Citation Score: 306.77598
- Max Citation Score: 310.447
- Similarity Product: 244.34623304188253

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test