PATENT CLAIM ANALYSIS

Application Number: 15957376
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["424", "186100"]

Abstract:
This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the minicircle DNA vector includes: a eukaryotic translation initiation nucleotide sequence, a mutant nucleotide sequence that encodes a foot-and-mouth disease virus (FMDV) capsid polyprotein precursor that contains at least one mutation to eliminate a restriction enzyme recognition site, a nucleotide sequence that encodes a protease that cleaves the FMDV capsid polyprotein precursor into a plurality of FMDV capsid proteins and a translational regulatory element to regulate the expression of the protease. The minicircle DNA vectors can be transfected directly into the cell of a mammalian host. When transfected into the mammalian host cell, virus-like particles can be produced intrinsically to stimulate the mammalian host's immune system to develop adaptive immunity toward foot-and-mouth disease.

Claim (Index 15):
The vector of  claim 14 , wherein said one of one through twenty-two (1-22) silent mutations, one through fifteen (1-15) silent mutations, or one through ten (1-10) silent mutations are selected from the group consisting of C99, C285, T345, G354, A369, C408, C468, G498, C528, A588, C597, C627, C957, G1170, T1338, T1518, C1578, T1593, C1665, C1836, C2010, A2190 or combinations thereof.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 91.0
- Lexical Diversity: 1.79268
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14962272', '15259409', '15407982', '14863181', '13502014']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7855670668838411
- 35 USC 102 Novelty (BERT): 0.59767563506574
- Combined Prediction Score: 0.766777923702031
- Mean Citation Score: 381.105392
- Max Citation Score: 751.46625
- Similarity Product: 431.0387522935866

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test