PATENT CLAIM ANALYSIS

Application Number: 15942312
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "293000"]

Abstract:
Methods for treating a subject having a cancerous tumor are disclosed. The methods comprise administering to the subject an effective amount of a non-steroidal selective glucocorticoid receptor modulator (SGRM) and an effective amount of a chemotherapeutic agent. The tumor may be cervical cancer. The SGRM may be a fused azadecalin. In embodiments, the SGRM may be a heteroaryl ketone fused azadecalin or an octahydro fused azadecalin.

Claim (Index 10):
The method of  claim 9 , wherein the heteroaryl ketone fused azadecalin has the formula: wherein\n R 1  is a heteroaryl ring having from 5 to 6 ring members and from 1 to 4 heteroatoms each independently selected from the group consisting of N, O and S, optionally substituted with 1-4 groups each independently selected from R 1a ; \n each R 1a  is independently selected from the group consisting of hydrogen, C 1-6  alkyl, halogen, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, CN, N-oxide, C 3-8  cycloalkyl, and C 3-8  heterocycloalkyl; \n ring J is selected from the group consisting of a cycloalkyl ring, a heterocycloalkyl ring, an aryl ring and a heteroaryl ring, wherein the heterocycloalkyl and heteroaryl rings have from 5 to 6 ring members and from 1 to 4 heteroatoms each independently selected from the group consisting of N, O and S; \n each R 1  is independently selected from the group consisting of hydrogen, C 1-6  alkyl, halogen, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkyl-C 1-6  alkoxy, CN, OH, NR 2a R 2b , C(O)R 2a , C(O)OR 2a , C(O)NR 2a R 2b , SR 2a , S(O)R 2a , S(O) 2 R 2a , C 3-8  cycloalkyl, and C 3-8  heterocycloalkyl, wherein the heterocycloalkyl groups are optionally substituted with 1-4 R 2c  groups; \n alternatively, two R 2  groups linked to the same carbon are combined to form an oxo group (\u2550O); \n alternatively, two R 2  groups are combined to form a heterocycloalkyl ring having from 5 to 6 ring members and from 1 to 3 heteroatoms each independently selected from the group consisting of N, O and S, wherein the heterocycloalkyl ring is optionally substituted with from 1 to 3 R 2d  groups; \n R 2a  and R 2b  are each independently selected from the group consisting of hydrogen and C 1-6  alkyl; \n each R 2c  is independently selected from the group consisting of hydrogen, halogen, hydroxy, C 1-6  alkoxy, C 1-6  haloalkoxy, CN, and NR 2a R 2b ; \n each R 2d  is independently selected from the group consisting of hydrogen and C 1-6  alkyl, or two R 2d  groups attached to the same ring atom are combined to form (\u2550O); \n R 3  is selected from the group consisting of phenyl and pyridyl, each optionally substituted with 1-4 R 3a  groups; \n each R 3a  is independently selected from the group consisting of hydrogen, halogen, and C 1-6  haloalkyl; and \n subscript n is an integer from 0 to 3; \n or salts and isomers thereof.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 90.0
- Lexical Diversity: 1.64444
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15915477', '15697878', '15236015', '15796443', '13901946']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8108661313460961
- 35 USC 102 Novelty (BERT): 0.6288670085221474
- Combined Prediction Score: 0.7926662190637012
- Mean Citation Score: 434.382624
- Max Citation Score: 579.2803
- Similarity Product: 536.2489632416069

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test