PATENT CLAIM ANALYSIS

Application Number: 15979128
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "236200"]

Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).

Claim (Index 12):
The compound of  claim 1 , which is selected from compounds of Formula (VIb-1), (VIb-2), (VIb-3), or (VIb-4), or a pharmaceutically acceptable salt thereof: wherein R 1  and R 2  are delineated for each compound in Table 6, TABLE 6 Entry R 1 R 2 501 Me   502 Me   503 Me   504 Me   505 Me   506 Me   507 Me   508 Me   509 Me   510 Me   511 CF 3   512 CF 3   513 CF 3   514 CF 3   515 CF 3   516 CF 3   517 CF 3   518 CF 3   519 CF 3   520 CF 3   521   522   523   524   525   526   527   528   529   530   531   532   533   534   535   536   537   538   539   540   541   542   543   544   545   546   547   548   549   550   551   552   553   554   555   556   557   558   559   560   561   562   563   564   565   566   567   568   569   570   571   572   573   574   575   576   577   578   579   580   581   582   583   584   585   586   587   588   589   590   591   592   593   594   595   596   597   598   599   600

Metadata:
- Claim Count in Document: 44.0
- Percentile: 93.0
- Lexical Diversity: 1.84416
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12974622', '15724919', '16063542', '14670421', '15597417']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7854739405701497
- 35 USC 102 Novelty (BERT): 0.5226347180972727
- Combined Prediction Score: 0.759190018322862
- Mean Citation Score: 304.51726799999994
- Max Citation Score: 310.5816700000001
- Similarity Product: 212.09926201300328

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test