PATENT CLAIM ANALYSIS

Application Number: 15947983
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "183000"]

Abstract:
The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

Claim (Index 29):
A compound having a chemical structure selected from: including stereoisomers and/or a pharmaceutically acceptable salt thereof; wherein\n W is \n HA is selected from nothing, hydrochloride, hydrobromide, hydroiodide, nitric acid, sulfic acid, bisulfic acid, phosphoric acid, phosphorous acid, phosphonic acid, isonicotinic acid, acetic acid, lactic acid, salicylic acid, citric acid, tartaric acid, pantothenic acid, bitartaric acid, ascorbic acid, succinic acid, maleic acid, gentisinic acid, fumaric acid, gluconic acid, glucaronic acid, saccharic acid, formic acid, benzoic acid, glutamic acid, methanesulfonic acid, ethanesulfonic acid, benzensulfonic acid, p-toluenesulfonic acid, and pamoic acid; R is selected from nothing and substituted and unsubstituted alkyl; R 1  and R 2  are independently selected from H, substituted and unsubstituted alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted heterocycloalkyl, substituted and unsubstituted alkyloxyl, substituted and unsubstituted alkenyl, substituted and unsubstituted alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heteroaryl residues; R 5  is selected from H and substituted and unsubstituted alkyl; R 6  is selected from H, F, Cl, Br, I, Na + , K + , C(\u2550O)R 5 , 2-oxo-1-imidazolidinyl, phenyl, 5-indanyl, 2,3-dihydro-1H-inden-5-yl, 4-hydroxy-1,5-naphthyridin-3-yl, substituted and unsubstituted alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted heterocycloalkyl, substituted and unsubstituted alkenyl, substituted and unsubstituted alkynyl, substituted and unsubstituted alkyloxyl, substituted and unsubstituted cycloalkyloxyl, substituted and unsubstituted aryl, and substituted and unsubstituted heteroaryl; R 11 -R 13  are independently substituted and unsubstituted alkyl; X is selected from nothing, C(\u2550O), OC(\u2550O), CH 2 , CH, S, NH, NR 6 , and O; X 5  is selected from nothing, C(\u2550O), OC(\u2550O), CH 2 , CH, S, O and NR 5 ; X 6  is selected from nothing, C(\u2550O), OC(\u2550O), CH 2 , CH, S, O and NR 5 ; Y 1 -Y 4  are independently selected from H, OH, OC(\u2550O)CH 3 , CH 3 , C 2 H 5 , C 3 H 7 , C 4 H 9 , OCH 3 , OC 2 H 5 , CH 3 SO 2 , CH 3 SO 3 , NO 2 , CN, CF 3 , OCF 3 , CH 2 C(\u2550O)NH 2 , F, Br, I, Cl, substituted and unsubstituted perfluoroalkyl, substituted and unsubstituted alkoxyl, substituted and unsubstituted alkylthio, substituted and unsubstituted alkylamino, substituted and unsubstituted perfluoroalkyl, substituted and unsubstituted alkyl halide, and substituted and unsubstituted alkylcarbonyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 91.0
- Lexical Diversity: 1.8642
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13323556', '13550361', '12503739', '15402618', '13732256']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8057549880818101
- 35 USC 102 Novelty (BERT): 0.6791685760166835
- Combined Prediction Score: 0.7930963468752974
- Mean Citation Score: 491.28663200000005
- Max Citation Score: 764.9432
- Similarity Product: 650.5634823642731

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test