PATENT CLAIM ANALYSIS

Application Number: 16074750
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "025000"]

Abstract:
Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.

Claim (Index 5):
A method of treating cancer in a subject comprising administering to the subject an anti-proliferative effective amount of a compound of Formula 1:\n T&A-L 1 -Sugar\u2003\u2003 (I) \n wherein the T&A moiety is triptolide or one of its analogs, and can be selected from compounds 1 to 18: wherein L 1  can be selected from \u2014X\u2014Y\u2014Z\u2014, wherein X and Z can individually and independently be a direct bond, \u2014CH 2 \u2014, \u2014C(O)\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014OPO\u2014, \u2014OPO 2 \u2014, and wherein Y is a direct bond, a substituted or unsubstituted \u2014(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n O(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)O(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n NH(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)NH(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n S(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(CH 2 ) n S(C 1 -C 6 )alkyl-, substituted or unsubstituted \u2014(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n O(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)O(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n NH(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)NH(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n S(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(CH 2 ) n S(C 2 -C 6 )alkenyl-, substituted or unsubstituted \u2014(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n O(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)O(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n NH(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)NH(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n S(C 2 -C 6 )alkynyl-, substituted or unsubstituted \u2014(CH 2 ) n C(O)(CH 2 ) n S(C 2 -C 6 )alkynyl-, wherein each alkyl, alkenyl and alkynyl group may be optionally substituted with alkyl, alkoxy, amino, hydroxyl, oxo, aryl, heteroaryl, carboxyl, cyano, nitro, or trifluoromethyl; wherein the sugar can be selected from compounds 19 to 53: thereby treating the cancer.

Metadata:
- Claim Count in Document: 49.0
- Percentile: 96.0
- Lexical Diversity: 1.18519
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12575425', '14436387', '15114895', '15737683', '11617651']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7581851942585977
- 35 USC 102 Novelty (BERT): 0.5207230003217785
- Combined Prediction Score: 0.7344389748649158
- Mean Citation Score: 291.97641
- Max Citation Score: 319.12393
- Similarity Product: 216.0977020051944

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test