PATENT CLAIM ANALYSIS

Application Number: 15973645
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-01
Patent Classification: ["514", "179000"]

Abstract:
The present invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as medicament for the treatment of neuropathologies, in particular neuropathies induced by the chemotherapy of a cancer. These molecules according to the invention have both preventative and curative effects. The neurosteroids according to the invention may also be of use in the treatment of neurodegenerative disorders, in particular for preventing neuronal cell death. They may thus be used as neuroprotectants and/or as an agent that stimulates neuronal proliferation.

Claim (Index 1):
A derivative of allopregnanolone or 1-((3R,5S,10S,13S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone or epiallopregnanolone or 1-((3S,5S,10S,13S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H cyclopenta[a]phenanthren-17-yl)ethanone according to the following formula (I): wherein\n R 1  is a group chosen among the 3-alpha or 3-beta hydroxy groups, 3-alpha or 3-beta O-allyl groups, 3-alpha or 3-beta O-propargyl groups, 3-alpha or 3-beta O-glycol groups, 3-alpha or 3-beta O-PEG groups, 3-alpha or 3-beta O-glycol-allyl groups and 3-alpha or 3-beta O-PEG-allyl groups, \n A is a carbon atom substituted by an atom chosen among 5-H alpha and 5-H beta and B is a methylene group; or \n A and B are carbon atoms forming a 5,6-double bond; \n C is a carbon atom substituted by an atom chosen among 14-H alpha, 14-H beta, 14-alpha OH group and 14-beta OH and D is a methylene group; or \n C and D are carbon atoms forming a 14,15-double bond; \n F is a carbon atom substituted by an atom chosen among 17-H alpha and 17-H beta and E is a methylene group or a carbon atom substituted by a group chosen among 16-alkyl-alpha, 16-alkyl-beta, 16-OR 2 -alpha and 16-OR 2 -beta, with R 2  a group chosen among allyl, propargyl, glycol, PEG, glycol-allyl, PEG-allyl, or \n F is a carbon atom substituted by a group chosen among 17-alkyl-alpha, 17-alkyl-beta, 17-OR 2 -alpha and 17-OR 2 -beta, with R 2  a group chosen among allyl, propargyl, glycol, PEG, glycol-allyl, PEG-allyl, and E is a methylene group or a carbon atom substituted by group chosen among 16-alkyl-alpha, 16-alkyl-beta, 16-OR 2 -alpha and 16-OR 2 -beta, with R 2  a group chosen among allyl, propargyl, glycol, PEG, glycol-allyl, PEG-allyl, or \n E and F are involved in an epoxy cycle or a cyclopropyl and are chosen among 16,17-epoxy-alpha, 16,17-epoxy-beta, 16,17-methylene-alpha and 16,17-methylene-beta; or \n E and F are carbon atoms forming a 16,17-double bond; \n G is a carbonyl, a methylene or a carbon atom substituted by a 12-OR 3 -alpha or 12-OR 3 -beta group with R 3  a H atom or a group chosen among the acetyl, alkyl and aryl groups, R 3  being able to be chosen among ci-c6-alkyl, benzyl, p-methoxybenzyl, benzoyl, tigloyl, angeloyl, 2,2,2-trichloroethoxycarbonyl, o-aminobenzoyl, nicotinoyl, 2-methylbutyryl, isovaleryl, cinnamoyl, coumaroyl, o-hydroxybenzoyl and anthraniloyl, \n excluding (i) the molecule with formula (BR053) below: \n and\n (ii) the molecule with formula (BR338) below:

Metadata:
- Claim Count in Document: 27.0
- Percentile: 93.0
- Lexical Diversity: 1.55556
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15769223', '12070297', '11884537', '13708383', '14492530']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7688603667707621
- 35 USC 102 Novelty (BERT): 0.4869816704494637
- Combined Prediction Score: 0.7406724971386323
- Mean Citation Score: 196.493056
- Max Citation Score: 202.77733
- Similarity Product: 149.56812927722157

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test