PATENT CLAIM ANALYSIS

Application Number: 16078054
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "217100"]

Abstract:
Provided are a urea compound represented by general formula (I), a pharmaceutically acceptable salt thereof, a preparation method therefor, and use thereof as an FLT3 tyrosine protein kinase inhibitor, particularly in the prevention and/or treating of cancer.

Claim (Index 1):
A compound of general formula (I) or the pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein: X and Y are each independently selected from N and C\u2014BR 1 ; A and A1 are each independently selected from N and C\u2014BR 1 ; W and Z are each independently selected from N and C\u2014BR 1 ; in the absence of R 1 , B is identical or different and each is independently selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, alkynyl, cyano, cycloalkyl, heterocyclyl, aryl, or heteroaryl, said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl are optionally further substituted by one or more of Q groups; in the presence of R 1 , B is identical or different and each is independently selected from the group consisting of \u2014O\u2014 and \u2014NR 4 \u2014; and R 1  is identical or different and each is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, \u2014R u OR x , \u2014R u C(O) OR x , \u2014R u N(R y )(R z ), \u2014C(O)N(R y )(R z ), \u2014R u S(O) n N(R y )(R z ), \u2014R u S(O) n R x ; the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl groups are optionally further substituted by one or more groups selected from the group consisting of halogen, cyano, hydroxy, alkyl, alkoxy, hydroxyalkyl, hydroxyalkoxy, amido, cycloalkyl, heterocyclyl, aryl, haloaryl, heteroaryl, cycloalkyl-heteroaryl; R 4  is selected from the group consisting of hydrogen, alkyl, alkenyl, and alkynyl, or R4 and R 1  together with the nitrogen atom attached them form a heterocyclyl group or heteroaryl group, and the heterocyclyl group or heteroaryl group is optionally further substituted by one or more groups selected from the group consisting of halogen, alkyl, haloalkyl, alkoxy, and haloalkoxy; when R 2  is hydrogen, G is selected from the group consisting of aryl, heteroaryl, and heterocyclyl, and the aryl, heteroaryl, or heterocyclyl is optionally further substituted by one or more groups selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxy, amino, acyl, cycloalkyl, heterocyclic, aryl, and heteroaryl, wherein said alkyl, alkenyl, alkynyl, alkoxy, acyl, cycloalkyl, heterocyclic, aryl, or heteroaryl is optionally further substituted by one or more groups selected from the group consisting of halogen, alkyl, haloalkyl, alkenyl, alkynyl, aryl, hydroxy, alkoxy, halo alkoxy, cycloalkyl, ester, and cyano; or, when R 2  is not hydrogen, G and R 2  together with the nitrogen atom attached them form a heterocyclyl or heteroaryl group, the heterocyclyl or heteroaryl group is optionally further substituted by one or more groups selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxy, amino, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein said alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally further substituted by one or more groups selected from the group consisting of halogen, alkyl, haloalkyl, alkenyl, alkynyl, aryl, hydroxy, alkoxy, haloalkoxy, cycloalkyl, ester, and cyano; R 3  is selected from the Q group; R u  is selected from a bond, alkylene, alkenylene, or alkynylene; R x  is selected from hydrogen, alkyl, hydroxyalkyl, haloalkyl, alkenyl, or alkynyl; or the oxygen in \u2014R u OR x \u2014 together with R u  and R x  attached to them form an oxygen-containing 3-7 membered heterocyclic ring, which is optionally substituted by one or more of Q groups; R y  and R z  are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, and haloalkyl; or, R y  and R z  together with the nitrogen atom attached to them form a heterocyclyl or heteroaryl group, and the heterocyclyl or heteroaryl group is optionally further substituted by one or more groups selected from the group consisting of halogen, haloalkyl, alkyl, alkenyl and alkynyl groups; Q is selected from the group consisting of hydrogen, halogen, hydroxy, amino, alkyl, alkoxy, cycloalkyl, alkenyl, alkynyl, cyano, aryl, heterocyclyl and heteroaryl, and the amino, alkyl, alkoxy, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, or heteroaryl is optionally further substituted by one or more groups selected from the group consisting of hydroxy, halogen and alkyl; n is an integer from 0 to 2.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 96.0
- Lexical Diversity: 1.15789
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14297790', '13389146', '10939324', '11201823', '12105408']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8274292800770462
- 35 USC 102 Novelty (BERT): 0.5258389579083487
- Combined Prediction Score: 0.7972702478601765
- Mean Citation Score: 335.0989120000001
- Max Citation Score: 349.75607
- Similarity Product: 250.43717358933569

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test