PATENT CLAIM ANALYSIS

Application Number: 15900680
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-11
Patent Classification: ["424", "009100"]

Abstract:
In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde-acetaldheyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.

Claim (Index 39):
A method of monitoring the progression of atherosclerosis in a mammal, said method comprising:\n determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde acetaldehyde adduct (MAA adduct) in a biological sample from said mammal; and comparing the level(s) of said antibodies to levels that have been measured for said mammal at a previous point in time, wherein:\n an increase in the total level(s) of antibodies that bind said MAA adduct in said biological sample, as compared to the previous determination, is an indicator that atherosclerotic lesions have worsened in said mammal; and \n a decrease in the total level(s) of antibodies that bind said MAA adduct in said biological sample, as compared to the previous determination, is an indicator that atherosclerotic lesions decreased in said mammal, or the risk of progression has decreased.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 88.0
- Lexical Diversity: 1.73846
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10557427', '14193391', '13865139', '14416555', '14155903']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6753176508644773
- 35 USC 102 Novelty (BERT): 0.5173341955480321
- Combined Prediction Score: 0.6595193053328328
- Mean Citation Score: 257.698636
- Max Citation Score: 276.2188
- Similarity Product: 185.84565700383183

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test