PATENT CLAIM ANALYSIS

Application Number: 15959809
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "04400A"]

Abstract:
This invention is intended to enhance and improve the resistance of a single- or double-stranded nucleic acid fragment comprising a base sequence of a functional nucleic acid to degradation by nucleolytic enzymes in a simple and cost-effective manner. The single- or double-stranded nucleic acid fragment comprises, ligated to at least one end thereof, hairpin-shaped DNA comprising: (A) a nucleic acid region comprising 2 to 5 arbitrary nucleotides; (B) a nucleic acid region comprising a “gna” or “gnna” base sequence, wherein each “n” represents “g”, “t”, “a”, or “c”, a base analogue, or a modified base; and (C) a nucleic acid region comprising a base sequence complementary to the nucleic acid region (A), sequentially from the 5′ end toward the 3′ end.

Claim (Index 1):
A nucleic acid comprising:\n a hairpin-shaped DNA comprising nucleic acid regions (A) to (C) below sequentially ligated from the 5\u2032 end toward the 3\u2032 end:\n (A) a first nucleic acid region comprising 2 to 5 arbitrary nucleotides; \n (B) a second nucleic acid region comprising a \u201cgna\u201d or \u201cgnna\u201d base sequence, \n wherein each \u201cn\u201d independently represents \u201cg\u201d, \u201ct\u201d, \u201ca\u201d, or \u201cc\u201d, a base analogue, or a modified base; and \n (C) a third nucleic acid region comprising a base sequence complementary to the first nucleic acid region, \n wherein the first nucleic acid region and the third nucleic acid region form a stem portion by base pairing with each other and the second nucleic acid region forms a loop portion, and \n a nucleic acid fragment (1) or (2) below: \n (1) a single-stranded nucleic acid fragment comprising a DNA aptamer; or \n (2) a double-stranded nucleic acid fragment made by complete or partial base pairing and comprising an siRNA base sequence; \n wherein at least one end of the nucleic acid fragment is ligated to the hairpin-shaped DNA, \n wherein the nucleic acid comprises two hairpin-shaped DNAs when the nucleic acid fragment is the double-stranded nucleic acid fragment (2).

Metadata:
- Claim Count in Document: 15.0
- Percentile: 91.0
- Lexical Diversity: 2.15068
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14355711', '12735222', '10567168', '12996362', '14514112']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7175649770277871
- 35 USC 102 Novelty (BERT): 0.5415297329645418
- Combined Prediction Score: 0.6999614526214626
- Mean Citation Score: 358.255958
- Max Citation Score: 375.12192000000016
- Similarity Product: 273.4875698547364

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test