PATENT CLAIM ANALYSIS

Application Number: 16078054
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "217100"]

Abstract:
Provided are a urea compound represented by general formula (I), a pharmaceutically acceptable salt thereof, a preparation method therefor, and use thereof as an FLT3 tyrosine protein kinase inhibitor, particularly in the prevention and/or treating of cancer.

Claim (Index 17):
The compound of general formula (I) or the pharmaceutically acceptable salt, solvate or prodrug thereof according to  claim 1 , wherein, the compound is selected from the group consisting of:\n 1-(4-benzimidazol-1-yl-phenyl)3-isoxazol-3-yl-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-methyl-isoxazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-hydroxy-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-methoxyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-ethoxyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-hexyloxyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-isopropoxy-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[5-(3-methyl-oxetan-3-ylmethoxy)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[5-(tetrahydrofuran-2-ylmethoxy)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[5-(2-hydroxy-ethoxyl)-benzimidazol-1-yl]-phenyl]urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[5-(2-methoxyl-ethoxyl)-benzimidazol-1-yl]-phenyl]urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[5-(2-ethoxyl-ethoxyl)-benzimidazol-1-yl]-phenyl]urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-{5-[2-(2-hydroxy-ethoxyl)-ethoxyl]-benzimidazol-1-yl}-phenyl)-urea; 1-{4-[3-(5-tert-butyl-isoxazol-3-yl)-carbamido]-phenyl}-1H-benzimidazol-5-yl morpholine-4-carboxylicate; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[5-(2-morpholin-4-yl-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[5-(2-piperidine-1-yl-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-{4-[5-(2-azacycloheptan-1-yl-ethoxyl)-benzimidazol-1-yl]-phenyl}-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-{5-[3-(4-methyl-piperazin-1-yl)-propoxyl]-benzimidazol-1-yl}-phenyl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[5-(2-dimethylamino-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-trifluoromethoxy-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-fluor-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-trifluoromethyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-methyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(6-methoxyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[6-(2-methoxyl-ethoxyl)-benzimidazol-1-yl]-phenyl]urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[6-(2-morpholin-4-yl-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-{6-[(2-dimethylamino-ethyl)-methyl-amino]-benzimidazol-1-yl}-phenyl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[6-(4-methyl-piperazin-1-yl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-{4-[7-(2-morpholin-4-yl-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5,6-dimethoxyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5,6-dimethyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-fluoro-7-methyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(4-fluor-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(2-methyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(2-chlorobenzimidazole-1-yl)-phenyl]-urea; 1-(4-benzimidazol-1-yl-3-methyl-phenyl)-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-3-chloro-phenyl)-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-3-fluoro-phenyl)-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-3,5-difluoro-phenyl)-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-2-chloro-phenyl)-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(6-benzimidazol-1-yl-pyridin-3-yl)-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(2-benzimidazol-1-yl-pyrimidin-5-yl)-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-indol-1-yl-phenyl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-indazol-1-yl-phenyl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(6-fluoro-indazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(7-fluoro-indazol-1-yl)-phenyl]-urea; 1-(4-benzotriazol-1-yl-phenyl)-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-pyrrolo[2,3-b]pyridin-1-yl-phenyl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-imidazo[4,5-b]pyridin-3-yl-phenyl)-urea; 1-[4-(6-bromo-imidazo[4,5-b]pyridin-3yl)-phenyl]-3-(5-tert-butyl-isoxazol-3-yl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(6-trifluoromethyl-imidazo[4,5-b]pyridin-3-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-chloroimidazo[4,5-b]pyridin-3-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(5-methylimidazo[4,5-b]pyridin-3-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(7-methylimidazo[4,5-b]pyridin-3-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-imidazo[4,5-b]pyridin-1-yl-phenyl)-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(6-methoxyl-purin-7-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(6-methoxyl-purin-9-yl)-phenyl]-urea; 1-(5-tert-butyl-isoxazol-3-yl)-3-[4-(6-dimethylamino-purine-7-yl)-phenyl]-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-thiazol-2-yl-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(4-methyl-thiazole-2-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-[1,3,4]thiadiazole-2-yl-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-tert-butyl-[1,3,4]thiadiazole-2-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-methyl-1H-pyrazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-phenyl-1H-pyrazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-cyclopropyl-2H-pyrazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-trifluoromethyl-2H-pyrazole-3-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-tert-butyl-2H-pyrazole-3-yl)-urea; 1-(5-tert-butyl-2H-pyrazole-3-yl)-3-[4-(5-fluor-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-2H-pyrazole-3-yl)-3-[4-(5-trifluoromethyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-2H-pyrazole-3-yl)-3-[4-(5-methoxyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-2H-pyrazole-3-yl)-3-[4-(5-ethoxyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-2H-pyrazole-3-yl)-3-[4-(5-hexyloxyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-2H-pyrazole-3-yl)-3-[4-(5-isopropoxy-benzimidazol-1-yl)-phenyl]-urea; 1-[4-(5-sec-butoxyl-benzimidazol-1-yl)-phenyl]-3-(5-tert-butyl-2H-pyrazol-3-yl)-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-[4-(5-isobutoxy-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(2-methoxyl-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(2-ethoxyl-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(2-hydroxy-ethoxyl)-benzimidazol-1-yl]-phenyl]urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(2-hydroxy-3-methoxyl-propoxyl)-benzimidazol-1-yl]-phenyl]urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(3-dimethylamino-propoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(3-dibutylaminopropyloxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-[4-(5-cyanomethoxy-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-[4-(5-trifluoromethoxy-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(3-methyl-oxetan-3-ylmethoxy)-benzimidazole-1-yl]-phenyl]urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(tetrahydrofuran-2-ylmethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(tetrahydrofuran-2-ylmethoxyl)-benzimidazol-1-yl]-phenyl}-urea; Ethyl (1-{4-[3-(5-tert-butyl-2H-pyrazole-3-yl)-carbamido]-phenyl}-1H-benzimidazol-5-yloxy)-acetate; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(2-morpholin-4-yl-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(2-piperidine-1-yl-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-{4-[5-(2-azacycloheptan-1-yl-ethoxyl)-benzimidazol-1-yl]-phenyl}-3-(5-tert-butyl-2H-pyrazol-3-yl)-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-(4-{5-[3-(4-methyl-piperazin-1-yl)-propoxyl]-benzimidazol-1-yl}-phenyl)-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(3-fluoro-benzyloxy)-benzimidazol-1-yl]-phenyl]urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-(4-{5-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-benzimidazol-1-yl}-phenyl)-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[5-(4-morpholin-4-yl-[1,2,5]thiadiazol-3-yloxy)-benzimidazol-1-yl]-phenyl]urea; 4-(1-{4-[3-(5-tert-butyl-2H-pyrazol-3-yl)-carbamido]-phenyl}-1H-benzimidazol-5-yloxy)-pyridin-2-carboxylic acid methylamine; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-[4-(5-fluoro-7-methyl-benzimidazol-1-yl)-phenyl]-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-{4-[6-(2-methoxyl-ethoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(5-tert-butyl-2H-pyrazol-3-yl)-3-[4-(5,6-dimethoxyl-benzimidazol-1-yl)-phenyl]-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-urea; 1-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-3-{4-[5-(2-methoxyl-ethoxyl)-benzimidazol-1-yl]-phenyl]urea; 1-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-3-{4-[5-(2-morpholin-4-yl-methoxyl)-benzimidazol-1-yl]-phenyl}-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-[5-tert-butyl-2-(2-hydroxy-ethyl)-2H-pyrazol-3-yl]-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-tert-butyl-2-phenyl-2H-pyrazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-[5-tert-butyl-2-(4-methoxyl-phenyl)-2H-pyrazole-3-yl]-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-[5-tert-butyl-2-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-[5-tert-butyl-2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-[5-tert-butyl-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl]-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(5-tert-butyl-2-pyridin-2-yl-2H-pyrazol-3-yl)-urea; 4-{5-[3-(4-benzimidazol-1-yl-phenyl)-carbamido]-3-tert-butyl-pyrazol-1-yl}-benzoate; 1-(2-acryl-5-tert-butyl-2H-pyrazol-3-yl)-3-(4-imidazol-1-yl-phenyl)-urea; 3-amino-5-methylpyrazol-1-carboxylic acid (4-benzimidazol-1-yl-phenyl)-amide; 5-amino-3-cyclopropylpyrazol-1-carboxylic acid (4-benzimidazol-1-yl-phenyl)-amide; 5-amino-3-trifluoromethylpyrazol-1-carboxylic acid (4-benzimidazol-1-yl-phenyl)-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid (4-benzimidazol-1-yl-phenyl)-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid [4-(5-hexyloxyl-benzimidazol-1-yl)-phenyl]-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid (4-{5-[3-(4-methyl-piperazin-1-yl)-propoxyl]-benzimidazol-1-yl}phenyl)-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid {4-[5-(2-morpholin-4-yl-ethoxyl)-benzimidazol-1-yl]-phenyl}-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid {4-[5-(2-methoxyl-ethoxyl)-benzimidazol-1-yl]-phenyl}-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid {4-[5-(2-hydroxy-ethoxyl)-benzimidazol-1-yl]-phenyl}-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid {4-[5-(tetrahydrofuran-2-ylmethoxyl)-benzimidazol-1-yl]-phenyl}-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid {4-[5-(tetrahydrofuran-2-ylmethoxy)-benzimidazol-1-yl]-phenyl}-amide; (1-{4-[(5-amino-3-tert-butyl-pyrazol-1-carbonyl)-amino]-phenyl}-1H-benzimidazol-5-yloxyl)-acetic acid; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid [4-(5-fluoro-benzimidazol-1-yl)-phenyl]-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid [4-(5-trifluoromethyl-benzimidazol-1-yl)-phenyl]-amide; 4-(1-{4-[(5-amino-3-tert-butyl-pyrazol-1-carbonyl)-amino]-phenyl}-1H-benzimidazol-5-yloxyl)-pyridin-2-carboxylate acid methylamide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid {4-[6-(2-methoxyl-ethoxyl)-benzimidazol-1-yl]-phenyl}-amide; 5-amino-3-tert-butyl-pyrazol-1-carboxylic acid [4-(5,6-dimethoxyl-benzimidazol-1-yl)-phenyl]-amide; 3-tert-butyl-pyrazol-1-carboxylic acid (4-benzimidazol-1-yl-phenyl)-amide; 1-(4-benzimidazol-1-yl-phenyl)-3-(3,4-dimethyl-isoxazol-5-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(3-isopropyl-isoxazol-5-yl)-urea; 1-(4-benzimidazol-1-yl-phenyl)-3-(3-tert-butyl-isoxazol-5-yl)-urea.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 96.0
- Lexical Diversity: 1.15789
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14297790', '13389146', '10939324', '11201823', '12105408']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8272585812551534
- 35 USC 102 Novelty (BERT): 0.5246293419556531
- Combined Prediction Score: 0.7969956573252034
- Mean Citation Score: 335.0989120000001
- Max Citation Score: 349.75607
- Similarity Product: 275.07847130238537

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test