PATENT CLAIM ANALYSIS

Application Number: 15948709
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["800", "018000"]

Abstract:
The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

Claim (Index 2):
A method of obtaining an antigen specific antibody or antigen binding fragment thereof, said antigen-specific antibody comprising a human immunoglobulin light (IgL) chain comprising a human IgL chain lambda (\u03bb) variable region and a human IgL chain constant region, said antigen-binding fragment thereof comprising said human IgL chain \u03bb variable region, the method comprising:\n expressing said antibody from a cell comprising nucleic acid encoding said human IgL chain \u03bb variable region and said human IgL chain constant region of said antibody, or expressing said antigen binding fragment thereof, from a cell comprising nucleic acid encoding said human IgL chain \u03bb variable region, \n wherein said nucleic acid encoding said human IgL chain \u03bb variable region is of a transgenic mouse contacted with said antigen, \n wherein the germline of said transgenic mouse comprises a immunoglobulin light chain (IgL) locus, \n said IgL locus comprising human IgL chain \u03bb variable region gene segments consisting of one human V\u03bb gene segment and one human J\u03bb gene segment, said human V\u03bb gene segment is selected from the group consisting of functional V\u03bb gene segments from V\u03bb2-18 to V\u03bb3-1 of a human \u03bb light chain locus, \n said human J\u03bb gene segment is selected from the group consisting of functional J gene segments from J\u03bb1 to J\u03bb7 of a human \u03bb light chain locus, \n wherein said human \u03bb V region light chain gene segments are positioned\n (i) at an endogenous mouse immunoglobulin light chain locus comprising a light chain locus enhancer and \n (ii) upstream of a constant region, \n \n said homozygous IgL locus being functional to express an immunoglobulin light chain comprising a human \u03bb variable region, \n wherein said transgenic mouse comprises splenic B cells expressing immunoglobulin light chains comprising human \u03bb variable regions, \n wherein said transgenic mouse comprises immunoglobulin gamma antibody comprising human \u03bb variable regions.

Metadata:
- Claim Count in Document: 51.0
- Percentile: 91.0
- Lexical Diversity: 1.61111
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15383202', '15383196', '15018670', '13434361', '15095315']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7012812645644344
- 35 USC 102 Novelty (BERT): 0.7254464633959994
- Combined Prediction Score: 0.7036977844475909
- Mean Citation Score: 820.79571
- Max Citation Score: 852.8303
- Similarity Product: 814.1984032029035

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test