PATENT CLAIM ANALYSIS

Application Number: 16000969
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["544", "277000"]

Abstract:
Provided herein are Aminopurine compounds of Formula I: or pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein R 1 , R 2 , and R 3  are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing animal and human protozoal infections.

Claim (Index 22):
A method for the treatment or prevention of trypanosomosis, trypanosomiasis, or leishmaniasis, the method comprising administering to a subject having trypanosomosis, trypanosomiasis, or leishmaniasis an effective amount of a compound, wherein the compound is:\n 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-(tetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1r,4r)-4-aminocyclohexyl)-N8-(3-chlorophenyl)-N2-cyclopropyl-9H-purine-2,8-diamine, 9-((1r,4r)-4-aminocyclohexyl)-N8-(3-chlorophenyl)-N2-(cyclopropylmethyl)-9H-purine-2,8-diamine, 9-((1r,4r)-4-aminocyclohexyl)-N8-(3-chlorophenyl)-N2-(2,2,2-trifluoroethyl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-methyl-N2-(tetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, ((1s,4s)-4-(8-(3-chlorophenylamino)-2-(tetrahydro-2H-pyran-4-ylamino)-9H-purin-9-yl)cyclohexyl)methanol, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2,N2-dimethyl-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-methyl-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chlorophenyl)-N2-(2,2,2-trifluoroethyl)-9H-purine-2,8-diamine, 4-(9-((1s,4s)-4-(aminomethyl)cyclohexyl)-8-(3-chlorophenylamino)-9H-purin-2-ylamino)-1-methylcyclohexanol, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chloro-5-(trifluoromethyl)phenyl)-N2-(tetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(3-chloro-2-fluorophenyl)-N2-(tetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(2-fluoro-5-(trifluoromethyl)phenyl)-N2,N2-dimethyl-9H-purine-2,8-diamine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N-(2-fluoro-5-(trifluoromethyl)phenyl)-2-(pyrrolidin-1-yl)-9H-purin-8-amine, 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(2-fluoro-5-(trifluoromethyl)phenyl)-N2-(tetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, or 9-((1s,4s)-4-(aminomethyl)cyclohexyl)-N8-(5-chloro-2-fluorophenyl)-N2-(tetrahydro-2H-pyran-4-yl)-9H-purine-2,8-diamine, or a pharmaceutically acceptable salt, tautomer, isotopologue, or stereoisomer thereof.

Metadata:
- Claim Count in Document: 95.0
- Percentile: 94.0
- Lexical Diversity: 1.43902
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15611061', '15611108', '16000968', '15335619', '14874513']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7909380958369094
- 35 USC 102 Novelty (BERT): 0.6196376852666704
- Combined Prediction Score: 0.7738080547798856
- Mean Citation Score: 476.6811080000001
- Max Citation Score: 714.4842
- Similarity Product: 483.4941808191061

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test