PATENT CLAIM ANALYSIS

Application Number: 15745230
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-10
Patent Classification: ["424", "178100"]

Abstract:
The present invention belongs to the field of tumor therapy and molecular immunology, and relates to a PDL-1 antibody, a pharmaceutical composition thereof and use thereof. In particular, the present invention relates to a PDL-1 monoclonal antibody or an antigen-binding fragment thereof, wherein the monoclonal antibody has a heavy chain variable region comprising CDRs as set forth in SEQ ID NOs: 15-17; and/or has a light chain variable region comprising CDRs as set forth in SEQ ID NOs: 18-20. The monoclonal antibody of the present invention can bind to PDL-1 specifically, and specifically remove immunosuppressive function of PDL-1 and activate T lymphocytes.

Claim (Index 24):
Use of the monoclonal antibody or an antigen-binding fragment thereof of  claim 1  or  8 , or the conjugate of  claim 18  or  19 , or the multispecific antibody of  claim 20  in the manufacture of a medicament for prophylaxis and/or treatment and/or adjuvant treatment and/or diagnosis of a tumor or anemia;\n preferably, said tumor is selected from breast cancer, lung cancer such as non-small cell lung cancer, liver cancer, gastric cancer, colorectal cancer such as colon cancer or rectal cancer, esophageal cancer, ovarian cancer, cervical cancer, kidney cancer, prostate cancer, bladder cancer, pancreatic cancer, glioma, melanoma and leukemia.

Metadata:
- Claim Count in Document: 132.0
- Percentile: 86.0
- Lexical Diversity: 1.88333
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15500744', '15761262', '14603808', '13297783', '12738883']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7530575756744416
- 35 USC 102 Novelty (BERT): 0.556162590681196
- Combined Prediction Score: 0.7333680771751171
- Mean Citation Score: 370.982902
- Max Citation Score: 441.19925
- Similarity Product: 312.8934172358513

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test