PATENT CLAIM ANALYSIS

Application Number: 16221006
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["514", "277000"]

Abstract:
The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the CIC-1 ion channel.

Claim (Index 10):
The compound according to  claim 1 , wherein the compound is selected from the group consisting of:\n (2S)-2-[4-bromo-2-(1,2-oxazol-5-yl)phenoxy]butanoic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-3-yl)phenoxy]butanoic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-3-yl)phenoxy]-3-methylbutanoic acid; (2S)-2-{4-bromo-2-[3-(propan-2-yl)-1,2-oxazol-5-yl]phenoxy}propanoic acid; (2S)-2-[4-bromo-2-(4-methyl-1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-chloro-6-(1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(pyridin-2-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(5-methyl-1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(5-cyclopropyl-1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[2-(1,3-benzothiazol-2-yl)-4-bromophenoxy]propanoic acid; (2S)-2-[4-chloro-2-(1,3-thiazol-2-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(3-methyl-1,2-oxazol-5-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1H-imidazol-2-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1H-imidazol-4-yl)phenoxy]propanoic acid; (2R)-2-[4-bromo-2-(1,2-oxazol-5-yl)phenoxy]-3-fluoropropanoic acid; (2S)-2-[4-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(1H-pyrazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(thiophen-2-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(1,2-oxazol-5-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(1-methyl-1H-pyrazol-4-yl)phenoxy]propanoic acid; (2S)-2-[2-(1,3-benzothiazol-2-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1,3,4-oxadiazol-2-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-5-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(1H-pyrazol-1-yl)phenoxy]propanoic acid; (2S)-2-[4,5-dichloro-2-(1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-5-fluoro-2-(1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-5-fluoro-2-(1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1,3-oxazol-4-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(1,2-oxazol-3-yl)phenoxy]-3-cyclopropylpropanoic acid; (2S)-2-[4-fluoro-2-(1,2-oxazol-3-yl)phenoxy]propanoic acid; (2R)-2-[4-chloro-2-(1,2-oxazol-3-yl)phenoxy]-3-fluoropropanoic acid; (2S)-2-[4-chloro-2-(4-methyl-1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(5-cyclopropyl-1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(1,2-oxazol-3-yl)phenoxy]-3-methylbutanoic acid; (2S)-2-[4-chloro-2-(1,2-oxazol-3-yl)phenoxy]butanoic acid; (2S)-2-[4-chloro-2-(1,2-oxazol-3-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-3-yl)phenoxy]-3-cyclopropylpropanoic acid; (2S)-2-[4-chloro-2-(1,3-oxazol-2-yl)phenoxy]propanoic acid; (2R)-2-[4-bromo-2-(1,2-oxazol-3-yl)phenoxy]-3-fluoropropanoic acid; (2S)-2-[4-bromo-2-(2H-1,2,3-triazol-4-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-5-fluoro-2-(1,2-oxazol-3-yl)phenoxy]-4-fluorobutanoic acid; (2S)-2-[4-bromo-2-(1,2,3-thiadiazol-4-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-3-yl)phenoxy]-4-fluorobutanoic acid; (2R)-2-[4-chloro-5-fluoro-2-(1,2-oxazol-5-yl)phenoxy]-3-fluoropropanoic acid; (2S)-2-[4-bromo-2-(1,3-thiazol-4-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-5-fluoro-2-(1,3-oxazol-4-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(1,2-oxazol-5-yl)phenoxy]-3-methyl butanoic acid; (2S)-2-[4-chloro-2-(1,2-oxazol-5-yl)phenoxy]-3-cyclopropylpropanoic acid; (2R)-2-[4-chloro-2-(1,2-oxazol-5-yl)phenoxy]-3-fluoropropanoic acid; (2S)-2-[4-chloro-5-fluoro-2-(1,2-oxazol-5-yl)phenoxy]propanoic acid; (2S)-2-[4-chloro-2-(1,2-oxazol-5-yl)phenoxy]butanoic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-4-yl)phenoxy]propanoic acid; (2R)-2-[4-chloro-5-fluoro-2-(1,2-oxazol-3-yl)phenoxy]-3-fluoropropanoic acid; (2S)-2-[4-chloro-2-(1,3-oxazol-4-yl)phenoxy]propanoic acid; 2-[4-bromo-2-(1,2,3-thiadiazol-4-yl)phenoxy]acetic acid; 2-[4-chloro-2-(1,2-oxazol-5-yl)phenoxy]acetic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-5-yl)phenoxy]-2-cyclopropylacetic acid; (2S)-2-[4-bromo-5-fluoro-2-(1,2-oxazol-3-yl)phenoxy]-2-cyclopropylacetic acid; (2S)-2-[4-bromo-2-(1,2,3-thiadiazol-4-yl)phenoxy]-3-cyclopropylpropanoic acid; 2-[4-bromo-2-(4-methyl-1,2-oxazol-3-yl)phenoxy]acetic acid; 2-[4-bromo-5-fluoro-2-(1,2-oxazol-5-yl)phenoxy]acetic acid; (2S)-2-[4-bromo-5-fluoro-2-(1,2-oxazol-5-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-3-yl)phenoxy]-3-cyclobutylpropanoic acid; (2S)-2-[4-bromo-5-fluoro-2-(1,2,3-thiadiazol-4-yl)phenoxy]propanoic acid; 2-[4-bromo-2-(1,2-oxazol-5-yl)phenoxy]acetic acid; 2-[4-bromo-5-fluoro-2-(1,2-oxazol-3-yl)phenoxy]acetic acid; (2S)-2-[4-bromo-2-(1,2,3-thiadiazol-4-yl)phenoxy]butanoic acid; (2R)-2-[4-bromo-2-(1,2,3-thiadiazol-4-yl)phenoxy]-3-fluoropropanoic acid; (2S)-2-[4-bromo-2-(1,3,4-thiadiazol-2-yl)phenoxy]propanoic acid; 2-[4-bromo-2-(1,2-oxazol-3-yl)phenoxy]acetic acid; (2R)-2-[4-bromo-5-fluoro-2-(1,2-oxazol-3-yl)phenoxy]-3-fluoropropanoic acid; (2S)-2-[4-chloro-2-(1,2,3-thiadiazol-4-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1,3-oxazol-5-yl)phenoxy]propanoic acid; (2S)-2-[4-bromo-2-(1,2-oxazol-3-yl)phenoxy]-3-ethoxypropanoic acid; 2-[4-bromo-2-(1,3-oxazol-4-yl)phenoxy]acetic acid; and (2S)-2-[4-chloro-2-(1,2-thiazol-3-yl)phenoxy]propanoic acid.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 98.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15842823', '14580045', '13651312', '15232892', '11698781']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7655306117593595
- 35 USC 102 Novelty (BERT): 0.6942479126803642
- Combined Prediction Score: 0.75840234185146
- Mean Citation Score: 419.942236
- Max Citation Score: 793.0178
- Similarity Product: 676.2756156147838

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test