PATENT CLAIM ANALYSIS

Application Number: 15987365
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "256000"]

Abstract:
This invention provides for an improved method for differentially diagnosing ACTH-dependent Cushing's syndrome. Current practice for differentially diagnosing ectopic ACTH syndrome and Cushing's Disease measures relative ACTH concentrations from the inferior petrosal venous sinus compared to fluid obtained from a periphery venous sample. This is performed before and after administration of exogenous corticotropin releasing factor, or after administration of metyrapone. This invention uses glucocorticoid receptor antagonists to induce release of endogenous CRH which stimulates ACTH to increase in patients with ectopic ACTH syndrome but not in those with Cushing's Disease.

Claim (Index 13):
The method of  claim 12 , wherein the cyclohexyl pyrimidine has the following formula: wherein the dashed line is absent or a bond; Xis selected from the group consisting of O and S; R 1  is selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl and heteroaryl, optionally substituted with from 1 to 3 R 1a  groups; each R 1a  is independently selected from the group consisting of H, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  alkoxy, C 1-6  alkyl OR 1b , halogen, C 1-6  haloalkyl, C 1-6  haloaloxy, OR 1b , NR 1b R 1c , C(O)R 1b , C(O)OR 1b , OC(O)R 1b , C(O)NR 1b R 1c , NR 1b C(O)R 1c , SO 2 NR 1b R 1c , cycloalkyl, heterocycloalkyl, aryl and heteroaryl; R 1b  and R 1c  are each independently selected from the group consisting of H and C 1-6  alkyl; R 2  is selected from the group consisting of H, C 1-6  alkyl, C 1-6  alkyl-OR 1b , C 1-6  alkyl NR 1b R 1c  and C 1-6  alkylene heterocycloalkyl; R 3  is selected from the group consisting of H and C 1-6  alkyl; Ar is aryl, optionally substituted with 1-4 R 4  groups; each R 4  is independently selected from the group consisting of H, C 1-6  alkyl, C 1-6  alkoxy, halogen, C 1-6  haloalkyl and C 1-6  haloalkoxy; L 1  is a bond or C 1-6  alkylene; and subscript n is an integer from 0 to 3, or salts and isomers thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.48485
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15236015', '15796443', '15627414', '15697878', '15915477']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8203151146970646
- 35 USC 102 Novelty (BERT): 0.6962335923134763
- Combined Prediction Score: 0.8079069624587059
- Mean Citation Score: 512.1089400000002
- Max Citation Score: 713.4526
- Similarity Product: 704.8772032206416

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test