PATENT CLAIM ANALYSIS

Application Number: 16090385
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "326000"]

Abstract:
The present invention relates to piperidinylalkylamide derivatives having dual pharmacological activity towards both the sigma (σ) receptor and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

Claim (Index 13):
A compound of Formula (I): wherein m is 0, 1, 2, 3, 4 or 5; n is 1, 2, 3, 4 or 5; X is a group selected from the group consisting of pyrimidine, pyrazine, oxadiazole, thiazole, thiadiazole, triazole and indazole; R 1  is selected from the group consisting of substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted C 2-6  alkenyl, and substituted or unsubstituted C 2-6  alkynyl;\n wherein the alkyl, alkenyl or alkynyl in R 1 , if substituted, is substituted with one or more substituent/s selected from the group consisting of \u2014OR 4 , \u2014C(O)R 4 , halogen, \u2014CN, C 1-4  haloalkyl, C 1-4  haloalkoxy and \u2014NR 4 R 4\u2032 ; \n wherein R 4  is selected from the group consisting of hydrogen, unsubstituted C 1-6  alkyl, unsubstituted C 2-6  alkenyl and unsubstituted C 2-6  alkynyl; \n and R 4\u2032  is selected from the group consisting of hydrogen, unsubstituted C 1-6  alkyl, unsubstituted C 2-6  alkenyl, unsubstituted C 2-6  alkynyl and -Boc; \n R 2  is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl;\n wherein the aryl or heterocyclyl in R 2 , if substituted, is substituted with one or more substituent/s selected from the group consisting of halogen, \u2014R 5 , \u2014OR 5 , \u2014NO 2 , \u2014NR 5 R 5\u2032\u2033 , NR 5 C(O)R 5\u2032 , \u2014NR 5 S(O) 2 R 5\u2032 , \u2014S(O) 2 NR 5 R 5\u2032 , \u2014NR 5 C(O)NR 5\u2032 R 5\u2033 , \u2014SR 5 , \u2014S(O)R 5 , S(O) 2 R 5 , \u2014CN, C 1-4  haloalkyl, C 1-4  haloalkoxy, \u2014C(O)OR 5 , \u2014C(O)NR 5 R 5\u2032 , \u2014OCH 2 CH 2 OH, \u2014NR 5 S(O) 2 NR 5\u2032 R 5\u2033  and \u2014C(CH 3 ) 2 OR 5 ; \n and wherein the non-aromatic heterocyclyl in R 2 , if substituted, may also be spirosubstituted or substituted with \u2550O; \n wherein R 5 , R 5\u2032  and R 5\u2033  are independently selected from the group consisting of hydrogen, unsubstituted C 1-6  alkyl, unsubstituted C 2-6  alkenyl and unsubstituted C 2-6  alkynyl; \n and wherein R 5\u2032\u2033  is selected from the group consisting of hydrogen, unsubstituted C 1-6  alkyl, unsubstituted C 2-6  alkenyl, unsubstituted C 2-6  alkynyl and -Boc; \n R 3  is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl;\n wherein the aryl or heterocyclyl in R 3 , if substituted, is substituted with one or more substituent/s selected from the group consisting of halogen, \u2014R 6 , \u2014OR 6 , \u2014NO 2 , \u2014NR 6 R 6\u2032\u2033 , NR 6 C(O)R 6\u2032 , \u2014NR 6 S(O) 2 R 6\u2032 , \u2014S(O) 2 NR 6 R 6\u2032 , \u2014NR 6 C(O)NR 6\u2032 R 6\u2033 , \u2014SR 6 , \u2014S(O)R 6 , S(O) 2 R 6 , \u2014CN, C 1-4  haloalkyl, C 1-4  haloalkoxy, \u2014C(O)OR 6 , \u2014C(O)NR 6 R 6\u2032 , \u2014OCH 2 CH 2 OH, \u2014NR 6 S(O) 2 NR 6\u2032 R 6\u2033  and \u2014C(CH 3 ) 2 OR 6 ; \n and wherein the non-aromatic heterocyclyl in R 3 , if substituted, may also be spirosubstituted or substituted with \u2550O; \n wherein R 6 , R 6\u2032  and R 6\u2033  are independently selected from the group consisting of hydrogen, unsubstituted C 1-6  alkyl, unsubstituted C 2-6  alkenyl and unsubstituted C 2-6  alkynyl; \n and wherein R 6\u2032\u2033  is selected from the group consisting of hydrogen, unsubstituted C 1-6  alkyl, unsubstituted C 2-6  alkenyl, unsubstituted C 2-6  alkynyl and -Boc; \n optionally as a stereoisomer, including enantiomers and diastereomers, a racemate or a mixture of at least two of stereoisomers, including enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.325
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16090403', '15746877', '15747220', '15531810', '15571352']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8316632547391332
- 35 USC 102 Novelty (BERT): 0.5763040323551833
- Combined Prediction Score: 0.8061273325007382
- Mean Citation Score: 445.959034
- Max Citation Score: 473.35364
- Similarity Product: 396.8066522933435

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test