PATENT CLAIM ANALYSIS

Application Number: 15746241
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-11
Patent Classification: ["435", "199000"]

Abstract:
A non-naturally occurring microorganism having a 1,3-BDO pathway is provided. The microorganism expresses at least one of the following 1,3-BDO pathway enzymes: an aldolase that catalyzes condensation of two acetaldehydes to produce 3-hydroxybutanal; and an aldo-ketoreductase, oxidoreductase, aldehyde reductase or alcohol dehydrogenase that reduces 3-hydroxybutanal to 1,3-BDO. The organism may further express one or more enzymes for producing acetaldehyde. A biosynthetic process involves condensing two acetaldehyde molecules to 3-hydroxybutanal using an enzyme from class aldolases; and selectively reducing 3-hydroxybutanal to 1,3-BDO using an enzyme belonging to the class aldo-ketoreductase, oxidoreductase, aldehyde reductase or alcohol dehydrogenase. The process can further include producing acetaldehyde by a biosynthetic method.

Claim (Index 7):
The non-naturally occurring microorganism of claim wherein the aldolase enzyme comprises the following conserved amino acid residues in the active site of the enzyme: lysine167, lysine 201, aspartic acid 16 and aspartic acid 102, where the number associated with each residue refers to the residue number in the amino acid sequence of  E. coli  DERA of the SEQ ID NO. 20.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 86.0
- Lexical Diversity: 1.76119
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14692630', '12878980', '14673600', '13597095', '13011818']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.2210775838418081
- 35 USC 102 Novelty (BERT): 0.55361702091009
- Combined Prediction Score: 0.2543315275486363
- Mean Citation Score: 378.396708
- Max Citation Score: 416.0313
- Similarity Product: 313.7796019184768

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test