PATENT CLAIM ANALYSIS

Application Number: 16105479
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "231500"]

Abstract:
Disclosed are methods for treating a meylodysplastic syndrome (MDS) in a subject that involves administering to the subject a therapeutically effective amount of a protein phosphatase 2A (PP2A) inhibitor.

Claim (Index 59):
A method for treating myelodysplastic syndrome (MDS) in a subject afflicted therewith, comprising administering to the subject a therapeutically effective amount of a protein phosphatase 2A (PP2A) inhibitor; wherein the PP2A inhibitor is a compound having the structure: wherein\n bond \u03b1 is present or absent; \n R 1  and R 2  together are\u2550O; \n R 3  is OH, O \u2212 , OR 9 , O(CH 2 ) 1-6 R 9 , SH, S \u2212 , or SR 9 ,\n wherein R 9  is H, alkyl, alkenyl, alkynyl or aryl; \n \n R 4  is \n where X is O, S, NR 10 , N + HR 10  or N + R 10 R 10 ,\n where each R 10  is independently H, alkyl, alkenyl, alkynyl, aryl, \n \u2014CH 2 CN, \u2014CH 2 CO 2 R 11 , or \u2014CH 2 COR 11 ,\n wherein each R 11  is independently H, alkyl, alkenyl or alkynyl; \n R 5  and R 6  taken together are =O; \n R 7  and R 8  are each H, \n or a pharmaceutically acceptable salt, zwitterion, or ester thereof; \n wherein the MDS is low risk MDS, intermediate-1 risk MDS or del(5q) MDS.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 96.0
- Lexical Diversity: 1.21429
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15328235', '15816372', '15048389', '14783360', '14408475']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7380812680376123
- 35 USC 102 Novelty (BERT): 0.6666102909717672
- Combined Prediction Score: 0.7309341703310278
- Mean Citation Score: 336.052712
- Max Citation Score: 643.62946
- Similarity Product: 636.8007149246

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test