PATENT CLAIM ANALYSIS

Application Number: 16134831
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["424", "093100"]

Abstract:
The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.

Claim (Index 15):
A method for lowering blood glucose levels in a mammal comprising:\n (a) differentiating the pancreatic endoderm cells in a DMEM-high glucose medium comprising an exogenous retinoid to obtain a population of pancreatic endocrine precursor cells expressing NKX6.1 and PDX1, but not expressing CDX2; (b) differentiating the pancreatic endocrine precursor cells of step (a) in a DMEM-high glucose medium to obtain a population of cells expressing insulin; and (c) transplanting the population of insulin expressing cells of step (b) into the liver, natural pancreas, renal subcapsular space, omentum, peritoneum, subserosal space, intestine, or a subcutaneous pocket of the mammal, wherein the pancreatic endocrine precursor cells express insulin, lower the blood glucose levels in the mammal, and are protected from host immune response when transplanted.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 97.0
- Lexical Diversity: 1.125
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12838998', '12970330', '12839041', '13998883', '13998884']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7280120718050108
- 35 USC 102 Novelty (BERT): 0.7379518737604129
- Combined Prediction Score: 0.729006052000551
- Mean Citation Score: 649.751884
- Max Citation Score: 844.9823
- Similarity Product: 806.9468510318637

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test