PATENT CLAIM ANALYSIS

Application Number: 15762238
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "001100"]

Abstract:
The present invention provides 75 kD transmembrane neurotrophin receptor (p75 NTR ) antagonists and their use in prevention and treatment of loss of function, and adverse remodeling, in cardiac tissues subject to acute or chronic hemodynamic stress. Uses of the antagonists with or without additional cardiotropic agents for improving contractility and for treatment of congestive heart failure are also provided.

Claim (Index 9):
A method for identifying a target molecule as having p75 NTR  antagonist activity in vitro comprising:\n a) contacting one or more isolated cardiac myocytes with a solution comprising a target molecule or a control solution; b) contacting the isolated cardiac myocytes of a) contacted with the solution comprising the target molecule, or contacted with the control solution with a solution comprising an effective amount of proBDNF; c) generating images of the isolated cardiac myocytes using fluorescence microscopy; d) measuring contractility from the images of c); and e) identifying the target molecule as having p75 NTR  antagonist when the amount of contractility and/or relaxation is increased in the isolated cardiac myocytes contacted with the solution comprising the target molecule relative to the isolated cardiac myocytes contacted with the control solution.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 90.0
- Lexical Diversity: 1.25
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13879226', '15135774', '15804339', '11722915', '12915352']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7172046643832699
- 35 USC 102 Novelty (BERT): 0.4965346095705648
- Combined Prediction Score: 0.6951376589019994
- Mean Citation Score: 190.191454
- Max Citation Score: 194.68834
- Similarity Product: 124.40599983777764

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test