PATENT CLAIM ANALYSIS

Application Number: 15876462
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["546", "118000"]

Abstract:
The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.

Claim (Index 53):
A method for treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound represented by a formula: or a pharmaceutically acceptable salt thereof, wherein n is an integer from 2 to 3; L 1  and L 2  are independently absent, \u2014O\u2014, \u2014NH\u2014, \u2014S\u2014, \u2014S(O)\u2014, S(O) 2 \u2014, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; X is absent, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene, wherein if X is substituted or unsubstituted phenylene and L 1  is absent, then R 1  is not substituted or unsubstituted pyridinyl, substituted or unsubstituted benzo-oxazolyl, substituted or unsubstituted phenyl, or substituted or unsubstituted quinazolinyl, and wherein if X is substituted or unsubstituted phenylene, then R 1  is not substituted or unsubstituted cyclohexyl; R 1  is substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein if R 1  is substituted or unsubstituted phenyl and X absent, then L 1  is not absent, and wherein if R 1  is substituted or unsubstituted phenyl, then X is not substituted or unsubstituted pyridinonyl, or substituted or unsubstituted imidazolyl; each R 2  is halogen; R 4 , R 5 , and R 6  are hydrogen; R 7 , and R 8  are independently hydrogen, halogen, \u2014OH, \u2014CF 3 , \u2014NO 2 , \u2014OR 10 , \u2014C(O)R 12 , \u2014NR 13 R 14 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3  is hydrogen, \u2014OH, \u2014CF 3 , \u2014OR 10 , \u2014C(O)R 12 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R 3  is optionally attached to X thereby forming a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; each instance of R 10  is independently \u2014C(O)R 15 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; each instance of R 12  and R 15  is independently hydrogen, \u2014NR 19 R 20 , \u2014OR 21 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; each instance of R 13  is independently hydrogen, \u2014C(O)R 15 , \u2014S(O) 2 R 16 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; each instance of R 14 , R 19 , R 20  and R 21  is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and each instance of R 16  is independently hydrogen, \u2014NR 19 R 20 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 86.0
- Lexical Diversity: 1.0
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14328256', '12307104', '11733758', '14966821', '12567258']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8021834461063327
- 35 USC 102 Novelty (BERT): 0.5358740178477187
- Combined Prediction Score: 0.7755525032804713
- Mean Citation Score: 341.392426
- Max Citation Score: 393.86432
- Similarity Product: 293.71119742012024

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test