PATENT CLAIM ANALYSIS

Application Number: 15996723
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["546", "256000"]

Abstract:
Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

Claim (Index 29):
A method for treating a cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of (a) a compound of formula (I) or a pharmaceutically acceptable salt thereof or (b) a composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein: X is \u2014S(O)\u2014 or \u2014SO 2 \u2014; each W, Y and Z is independently \u2014S\u2014, \u2014CH\u2550, \u2014O\u2014, \u2014N\u2550, or \u2014NH\u2014, provided that (1) at least one of W, Y and Z is not \u2014CH\u2550 and (2) when one of W is \u2014S\u2014 and the Y in the same ring is N, then the Z in the same ring is not \u2014CH\u2550; each R 1  and R 2  is independently C 1-6  alkylene-R 4 , N(R 3 )\u2014C(O)\u2014R 4 , \u2014C(O)\u2014N(R 3 )\u2014R 4 , N(R 3 )\u2014C(O)\u2014O\u2014R 4 , \u2014N(R 3 )\u2014C(O)\u2014N(R 3 )\u2014R 4 , \u2014O\u2014C(O)\u2014N(R 3 )\u2014R 4 , \u2014N(R 3 )\u2014C(O)\u2014C 1-6  alkylene-C(O)\u2014R 4 , \u2014N(R 3 )\u2014C(O)\u2014C 1-6  alkylene-N(R 3 )\u2014C(O)\u2014R 4  or \u2014N(R 3a )\u2014C(O)\u2014CH2-N(R 3 )\u2014C(O)\u2014R 4 ; each R 3  is independently hydrogen, C 1-6  alkyl or aryl; each R 4  is independently C 1-6  alkyl, C 1-6  alkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl, heterocyclyl, cycloalkyl or cycloalkylalkyl, each of which is substituted with 0-3 occurrences of R 5 , or two adjacent R 5  moieties, taken together with the atoms to which they are attached form a heterocyclyl, heteroaryl, cycloalkyl or aryl; each R 5  is independently oxo (\u2550O), C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, cyano, halo, \u2014OH, \u2014SH, \u2014OCF 3 , \u2014SO 2 \u2014C 1-6  alkyl, \u2014NO 2 , \u2014N(R 7 )\u2014C(O)\u2014C 1-6  alkyl, \u2014N(R 6 ) 2 , \u2014O\u2014C(O)\u2014C 1-6  alkyl, C 3-7  cycloalkyl, (C 3-7  cycloalkyl)alkyl, aryl, aryloxy, \u2014C(O)-aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl or heterocyclyl, wherein each aryl, heteroaryl or heterocyclyl is further substituted with 0-3 occurrences of R 7 ; each R 6  is independently hydrogen, fluoro, \u2014OH or C 1-6  alkyl; each R 7  is independently hydrogen, C 1-6  alkyl, \u2014OH, \u2014SH, cyano, halo, \u2014CF 3 , \u2014OCF 3 , \u2014SOO 2 \u2014C 1-6  alkyl, \u2014NO 2 , \u2014N(R 7 )\u2014C(O)\u2014C 1-6  alkyl, \u2014N(R 6 ) 2  or C 1-6  alkoxy; m is 1, 2 or 3; n is 1, 2 or 3; provided that when X is \u2014S(O)\u2014 or \u2014SO 2 \u2014, the sum of m and n is from 2 to 4; o is 1, 2 or 3; and p is 1, 2 or 3.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 94.0
- Lexical Diversity: 1.5
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14085947', '14646239', '14086003', '15127742', '14646634']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7855704498850967
- 35 USC 102 Novelty (BERT): 0.5710003942582023
- Combined Prediction Score: 0.7641134443224072
- Mean Citation Score: 416.439832
- Max Citation Score: 501.6011
- Similarity Product: 352.4845800300658

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test