PATENT CLAIM ANALYSIS

Application Number: 15889578
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["546", "112000"]

Abstract:
The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a  Plasmodium  parasite, such as malaria.

Claim (Index 1):
A compound of Formula I, or a pharmaceutical acceptable salt, tautomer or stereoisomer thereof, wherein\n n is 0, 1, 2 or 3; \n p is 0, 1, 2 or 3; \n L is selected from the group consisting of *\u2014(CHR 3 ) 1-3 \u2014, *\u2014CHR 3 N(R 2 )\u2014, *\u2014CHR 3 O\u2014, *\u2014CHR 3 S\u2014, *\u2014CHR 3 S(O)\u2014, *\u2014CHR 3 N(R 2 )CHR 3 \u2014, *\u2014C(O)\u2014, *\u2014C(O)N(R 2 )\u2014, *\u2014C(O)N(R 2 )CHR 3 \u2014, *\u2014N(R 2 )\u2014, *\u2014N(R 2 )CHR 3 \u2014, *\u2014N(R 2 )C(O)\u2014, *\u2014N(R 2 )C(O)N(R 2 )\u2014, *\u2014N(R 2 )S(O) 2 \u2014, wherein\n represents the point of attachment of L to the pyrazolo[1,5-a]pyridine fused ring depicted in Formula I; \n each R 2  is independently selected from the group consisting of hydrogen, C 1-6 alkyl, haloC 1-6 alkyl, R\u2014C 0-4 alkylene, and R\u2014C 0-4 alkylene-C(O)\u2014, wherein R is selected from the group consisting of hydroxyl, C 1-4 alkoxy, amino, C 1-4 alkylamino, C 3-6 cycloalkyl, C 4-6 heterocycloalkyl, and C 5-6 heteroaryl, wherein the C 3-6 cycloalkyl, C 4-6 heterocycloalkyl, and C 5-6 heteroaryl of R are each unsubstituted or substituted with 1-2 substituents independently selected from the group consisting of halo, amino, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, oxo, and C 5-6  heteroaryl; and \n each R 3  is independently selected from the group consisting of hydrogen and C 1-4 alkyl; \n \n Ring A is selected from the group consisting of C 6-10 aryl and C 5-10 heteroaryl; \n Ring C is selected from the group consisting of C 6-10 aryl, C 5-10 heteroaryl, C 5-7  cycloalkyl, C 5-7 heterocycloalkyl, and fused bicyclyl comprising a C 5-6 heterocycloalky fused to a phenyl; \n each R 1  is independently selected from the group consisting of halo, cyano, amino, C 1-4 alkyl, C 1-4 alkoxyl, \u2014C(O)NR 7 R 8 , \u2014NHC(O)R 11 , phenyl, and C 5-6  heteroaryl; wherein\n the phenyl and C 5-6 heteroaryl of R 1  are each unsubstituted or substituted with 1-2 substituents independently selected from the group consisting of C 1 -Alkyl, amino, halo, and C 1-4 alkylamino; \n R 7  and R 8  are each independently selected from hydrogen, C 1-4 alkyl and haloC 1-4 alkyl; \n R 11  is C 1-6 alkyl, unsubstituted or substituted with 1-2 substituents independently selected from the group consisting of amino, C 3-6 cycloalkyl and C 4-6 heterocycloalkyl; \n \n R 17  is selected from the group consisting of cyano, halo, C 1-4 alkyl, oxo, C 3-6 cycloalkyl, and \u2014SO 2 \u2014C 1-4 alkyl.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 88.0
- Lexical Diversity: 1.5102
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14443609', '14083203', '15220149', '15150038', '14382210']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7711413318740477
- 35 USC 102 Novelty (BERT): 0.6583094228568402
- Combined Prediction Score: 0.7598581409723268
- Mean Citation Score: 451.795378
- Max Citation Score: 627.8209
- Similarity Product: 624.5247423815547

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test