PATENT CLAIM ANALYSIS

Application Number: 15880385
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "300000"]

Abstract:
Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I): wherein R 1 , R 2 , and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Claim (Index 1):
A compound, of Formula (I): wherein: R 1  is chosen from aryl and heteroaryl, and may be optionally substituted with one or more R 3  substituents; R 2  is chosen from aryl or heteroaryl, and may be optionally substituted with one or more R 4  substituents; each R 3  is independently chosen from hydrogen, \u2014C 1-4 alkyl, \u2014OC 1-4 alkyl, \u2014NHC 1-4 alkyl, \u2014N(C 1-4 alkyl) 2 , cyano, \u2014C(O)N(R 6 ) 2 , \u2014C(O)C 1-4 alkyl, haloalkyl, oxo, and halo; each R 4  is independently chosen from hydrogen, \u2014C 1-4 alkyl, \u2014OC 1-4 alkyl, \u2014OC 1-6 cycloalkyl, \u2014OC 1-6 heterocycloalkyl, aryl, heteroaryl, haloalkyl, haloalkoxy, halo, \u2014NR 5 R 6 , \u2014(CH 2 ) m CR 7 \u2550CR 9 C(O)Me, \u2014(CH 2 ) m CR 7 \u2550CR 9 C(O)NR 7 2 , and \u2014(CH 2 ) m CR 7 \u2550CR 9 CN; R 5  is chosen from hydrogen, cyano, \u2014C(O)CF 3 , \u2014C(O)CH\u2550CH 2 , \u2014C(O)CR 7 \u2550CH 2 , \u2014C(O)CH\u2550CHR 7 , \u2014C(O)CR 7 \u2550CHR 7 , \u2014C(O)CH\u2550CR 7 2 , \u2014C(O)CH\u2550CHCH 2 R 8 , \u2014C(O)CH\u2550CHC(O)CH 2 R 8 , \u2014COC(CN)\u2550CHR 6 , \u2014C(O)(C(O)NH 2 )\u2550CHR 6 , \u2014S(O) 2 CH\u2550CH 2 , \u2014(CH 2 ) m CR 7 \u2550CR 9 C(O)Me, \u2014(CH 2 ) m CR 7 \u2550CR 9 C(O)NR 7 2 , and \u2014(CH 2 ) m CR 7 \u2550CR 9 CN; R 6  is chosen from hydrogen, \u2014C 1-4 alkyl, and \u2014(CH 2 ) n C 3-7 cycloalkyl; each R 7  is independently chosen from hydrogen, \u2014CN, \u2014C 1-4 alkyl, \u2014C 3-7 cycloalkyl, \u2014C 3-7  heterocycle, aryl, and heteroaryl where aryl and heteroaryl may be optionally substituted with one or more R 9 ; R 8  is chosen from hydrogen, \u2014C 1-4 alkyl, \u2014C 1-4 alkylaryl, \u2014C 1-4 alkylheteroaryl, \u2014C 3-7  cycloalkyl, \u2014C 3-7 heterocycle, \u2014OH, \u2014OC 1-4 alkyl, \u2014C 1-4 alkylOC 1-4 alkyl, \u2014NH 2 , \u2014NHC 1-4 alkyl, \u2014N(C 1-4 alkyl) 2 , heterocycle, aryl and heteroaryl; R 9  is chosen from hydrogen, \u2014C 1-4  alkyl, \u2014CN, \u2014CF 3 , \u2014C(O)Me, \u2014C(O)NH 2 , and aryl; R 10  is chosen from H and \u2014C 1-4 alkyl; R 11  is chosen from hydrogen and \u2014C 1-4 alkyl, optionally substituted with \u2014OPO(OR 12 ) 2 , \u2014OC(O)R 13 , or an amino acid; R 12  is chosen from hydrogen and \u2014C 1-6 alkyl; R 13  is \u2014C 1-6  alkyl; m is chosen from 1, 2 and 3; and n is chosen from 0, 1, 2, and 3 a salt thereof, an ester thereof, a free acid form thereof, a free base form thereof, a solvate thereof, a deuterated derivative thereof, a hydrate thereof, an N-oxide thereof, a clathrate thereof, a prodrug thereof, a polymorph thereof, a stereoisomer thereof, a geometric isomer thereof, a tautomer thereof, a mixture of tautomers thereof, an enantiomer thereof, a diastereomer thereof, a racemate thereof, a mixture of stereoisomers thereof, an isotope thereof (e.g., tritium, deuterium), or a combination thereof.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.37778
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15005627', '15609876', '14604016', '14603937', '15737535']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8008976871416937
- 35 USC 102 Novelty (BERT): 0.5351825355751785
- Combined Prediction Score: 0.7743261719850422
- Mean Citation Score: 333.2663320000001
- Max Citation Score: 369.8901
- Similarity Product: 334.9918582184673

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test