PATENT CLAIM ANALYSIS

Application Number: 15922759
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["506", "014000"]

Abstract:
Methods and compositions are provided for producing libraries of soluble random polypeptides. In the methods, the fraction of hydrophilic residues in the polypeptide is controlled so as to maintain the solubility of the polypeptide constructs.

Claim (Index 2):
A library of soluble polypeptides linked to polynucleotides encoding the polypeptides, comprising:\n a plurality of polynucleotides, each of the plurality of polynucleotides comprising a plurality of codons, wherein a proportion of hydrophilic or surface compatible amino acid residues encoded by said codons of said each of the plurality of polynucleotides satisfies the following formula:\n c \u2265(8/0.41 N )\u03021/3\u22120.05 \n where N=the number of amino acids in said each of the plurality of polynucleotides, and c=a fraction of amino acids that are hydrophilic or surface compatible in said each of the plurality of polynucleotides; and an encoded polypeptide linked to each of said each of the plurality of polynucleotides, wherein an amino acid sequence of the encoded polypeptide is encoded by the each of said each of the plurality of polynucleotides that is linked to the encoded polypeptide.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 90.0
- Lexical Diversity: 1.26667
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12525437', '11557466', '12112890', '13384362', '14481564']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5326516778785587
- 35 USC 102 Novelty (BERT): 0.4995498886782691
- Combined Prediction Score: 0.5293414989585298
- Mean Citation Score: 192.92072
- Max Citation Score: 278.70016
- Similarity Product: 251.3288243128204

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test