PATENT CLAIM ANALYSIS

Application Number: 15972972
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "093210"]

Abstract:
The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need thereof a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain and monitoring the levels of cytokines in the patient post T cell infusion to determine the type of second-line of therapy appropriate for treating the patient as a consequence of the presence of the CAR T cell in the patient.

Claim (Index 7):
The method of  claim 1  wherein the cancer is independently selected from the group consisting of:\n (i) a hematological malignancy selected from the group consisting of acute leukemia, acute lymphocytic leukemia, acute myelocytic leukemia, acute myelogenous leukemia, myeloblastic leukemia, promyelocytic leukemia, myelomonocytic leukemia, monocytic leukemia, erythroleukemia, chronic leukemia, chronic myelocytic leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia, polycythemia vera, lymphoma, Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, Waldenstrom's macroglobulinemia, heavy chain disease, myelodysplastic syndrome, hairy cell leukemia and myelodysplasia; \n (ii) pre-B ALL (pediatric indication), adult ALL, mantle cell lymphoma, diffuse large B cell lymphoma, further wherein the CAR is an anti-CD19 CAR; \n (iii) a solid tumor; \n (iv) a primary or metastatic cancer; and \n (v) a cancer that is refractory or resistant to conventional chemotherapy.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 93.0
- Lexical Diversity: 1.81034
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15094674', '14567426', '14568195', '14680860', '14568569']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.798474899989939
- 35 USC 102 Novelty (BERT): 0.5443229606525454
- Combined Prediction Score: 0.7730597060561997
- Mean Citation Score: 397.723566
- Max Citation Score: 411.00613
- Similarity Product: 318.81112353596933

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test