PATENT CLAIM ANALYSIS

Application Number: 16023363
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["540", "578000"]

Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Claim (Index 1):
A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein:  is selected from the group consisting of: 1) optionally substituted aryl; 2) optionally substituted heteroaryl; 3) optionally substituted-C 3 -C 12  cycloalkyl; 4) optionally substituted-C 3 -C 12  cycloalkenyl; 5) optionally substituted 3- to 12-membered heterocycloalkyl; 6) optionally substituted arylalkyl; 7) optionally substituted heteroarylalkyl; 8) optionally substituted-C 3 -C 12  cycloalkyl-C 1 -C 6  alkyl; 9) optionally substituted-C 3 -C 12  cycloalkenyl-C 1 -C 6  alkyl; and 10) optionally substituted 3- to 12-membered heterocycloalkyl-C 1 -C 6  alkyl;  is heteroaryl, which, when possible, is optionally substituted with one or more substituents which are not R 1 ;  is aryl or heteroaryl, which, when possible, is optionally substituted with one or more substituents which are not R 3 ; L is absent, \u2014CONH\u2014, or \u2014NHCO\u2014; One of X and Y is selected from O, S, and NR 4 , and the other is N or CR 5 ; Each R 1  and R 2  is independently selected from the group consisting of: halogen, cyano, nitro, hydroxyl, protected hydroxyl, amino, protected amino, optionally substituted-C 1 -C 8  alkyl, and optionally substituted-C 1 -C 8  alkoxy; Each R 3  is independently selected from the group consisting of:\n 1) halogen; \n 2) optionally substituted-C 1 -C 8  alkoxy; \n 3) optionally substituted-C 1 -C 8  alkyl; \n 4) optionally substituted-C 2 -C 8  alkenyl; \n 5) optionally substituted-C 2 -C 8  alkynyl; \n 6) optionally substituted-C 3 -C 12  cycloalkyl; \n 7) optionally substituted-C 3 -C 12  cycloalkenyl; \n 8) optionally substituted 3- to 12-membered heterocycloalkyl; \n 9) optionally substituted aryl; \n 10) optionally substituted heteroaryl; \n 11) optionally substituted arylalkyl; \n 12) optionally substituted aryloxy; \n 13) \u2014C(O)R 12 ; \n 14) \u2014C(O)NR 13 R 14 ; \n 15) \u2014C(O)NR 11 S(O) 2 R 12 ; \n 16) \u2014S(O) 2 NR 13 R 14 ; \n 17) \u2014NR 13 R 14 ; \n 18) \u2014NR 11 S(O) 2 R 12 ; \n 19) \u2014NR 11 C(O)R 12 ; \n 20) \u2014NR 11 C(O)NR 13 R 14 ; and \n 21) \u2014NR 11 C(O)NHS(O) 2 R 12 ; \n n is 0, 1, 2, 3 or 4; m is 0, 1, 2, 3 or 4; v is 0, 1, 2, or 3; R 4  is hydrogen or optionally substituted-C 1 -C 8  alkyl; R 5  is hydrogen, halogen, optionally substituted-C 1 -C 8  alkyl, or optionally substituted-C 1 -C 8  alkoxy; R 12  at each occurrence is independently selected from the group consisting of:\n 1) Hydrogen; \n 2) Halogen; \n 3) Hydroxyl; \n 4) optionally substituted-C 1 -C 8  alkoxy; \n 5) optionally substituted-C 1 -C 8  alkyl; \n 6) optionally substituted-C 2 -C 8  alkenyl; \n 7) optionally substituted-C 2 -C 8  alkynyl; \n 8) optionally substituted-C 3 -C 8  cycloalkyl; \n 9) optionally substituted-C 3 -C 8  cycloalkenyl; \n 10) optionally substituted 3- to 8-membered heterocycloalkyl; \n 11) optionally substituted aryl; \n 12) optionally substituted arylalkyl; \n 13) optionally substituted heteroaryl; and \n 14) optionally substituted heteroarylalkyl; \n R 11 , R 13  and R 14  are each independently selected from hydrogen, optionally substituted-C 1 -C 8 -alkyl, optionally substituted-C 2 -C 8 -alkenyl, optionally substituted-C 2 -C 8 -alkynyl; optionally substituted-C 3 -C 8 -cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, and optionally substituted heteroarylalkyl; alternatively R 13  and R 14  are taken together with the nitrogen atom they attached to form a heterocyclic ring.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 94.0
- Lexical Diversity: 1.63265
- Patent Class: 540.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15216119', '15159548', '15914016', '11997048', '15501079']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7857871679082072
- 35 USC 102 Novelty (BERT): 0.55465684383339
- Combined Prediction Score: 0.7626741355007255
- Mean Citation Score: 410.19655
- Max Citation Score: 430.20917
- Similarity Product: 331.5838913257015

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test