PATENT CLAIM ANALYSIS

Application Number: 15917555
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "275000"]

Abstract:
Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt thereof; wherein\n A is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, or alkyl, wherein each A is optionally substituted with 1-3 independent substituents R 5 ; \n X is NR 4  or O; \n each of R 1  and R 2  is, independently, hydrogen, cyano, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, heteroarylalkyl, heterocycloalkylalkyl, \u2014(CR h R i ) n -E-NR a C(O)R b , \u2014C(O)NR a R b , \u2014(CR h R i ) n -E-NR d SO 2 R d , \u2014(CR h R i ) n -G-SO 2 R d , \u2014CO 2 R e , \u2014COR f , or \u2014CH 2 OR f , wherein each R 1  and R 2  is optionally substituted with 1-3 independent substituents R 5 ; \n or R 1  and A together with the atoms to which they are attached form a heterocycloalkyl ring or fused bicyclic ring; \n R 3  is haloalkyl or \u2014OR g ; \n R 4  is hydrogen, alkyl, \u2014(CR h R i ) n C(O)NR a R b , \u2014C(O)(CR h R i ) n NR a R b , \u2014C(O)O(CR h R i ) n C(O)NR a R b , or \u2014(CR h R i ) n OP(O)(OR a ) 2 ; \n each occurrence of R 5  is, independently, halogen, cyano, alkyl, haloalkyl, \u2014NR a R b , \u2014NHSO 2 R c , \u2014(CH 2 ) n NR a R b , \u2014(CH 2 ) n C(O)NR a R b , \u2014(CH 2 ) n NR d SO 2 R d , \u2014S(O)R d , \u2014S(O) 2 R d , \u2014CO 2 R e , \u2014COR f , \u2014(CR e R f ) n OR f , \u2014OR f , or aryl substituted with 0-3 independent halogen, \u2014NR a R b , \u2014NHSO 2 R c , \u2014(CH 2 ) n NR a R b , \u2014(CH 2 ) n C(O)NR a R b , \u2014(CH 2 ) n NR d SO 2 R d , \u2014S(O)R d , \u2014S(O) 2 R d , \u2014CO 2 R e , \u2014COR f , \u2014(CR e R f ) n OR f , or \u2014OR f ; or two occurrences of R 5 , together with the atoms to which they are attached, form a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl ring; \n each n is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; \n each E is independently a bond, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; \n each G is independently heteroaryl or heterocycloalkyl; \n each occurrence of R a , R b , R c , R d , R e , and R f  is, independently, hydrogen, acyl, alkoxyalkyl, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, a nitrogen protecting group when attached to a nitrogen atom, or an oxygen protecting group when attached to an oxygen atom; or R a  and R b  together with the atoms to which they are attached form a heterocycloalkyl ring; or R e  and R f  together with the atoms to which they are attached form a cycloalkyl ring; or 2 instances of R d  together with the atoms to which they are attached form a heterocycloalkyl ring; \n R g  is haloalkyl; and \n each occurrence of R h  and R i  is, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, or heterocycloalkylalkyl.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 90.0
- Lexical Diversity: 1.1
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15763972', '15858015', '15815809', '15857950', '12843702']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7803952971804309
- 35 USC 102 Novelty (BERT): 0.5560890028304467
- Combined Prediction Score: 0.7579646677454325
- Mean Citation Score: 381.424428
- Max Citation Score: 410.94333
- Similarity Product: 332.0777876797432

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test