PATENT CLAIM ANALYSIS

Application Number: 16177149
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "300000"]

Abstract:
Diazanaphthalene compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a diazanaphthalene compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Claim (Index 14):
The compound of  claim 1 , wherein the compound of Formula I is selected from the group consisting of:\n N-(6-(1H-pyrazol-4-yl)cinnolin-3-yl)-1-isobutylpiperidine-4-carboxamide [1814]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)cyclopropanecarboxamide [1815]; 4,4-difluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [1816]; trans-4-methoxy-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [1817]; trans-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [1818]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) cyclohexane-1-carboxamide [1819]; trans-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [1820]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [1821]; (S)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1822]; (S)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)tetrahydrofuran-2-carboxamide [1823]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1824]; 1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1825]; 1-isopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1826]; 1-(tert-butyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1827]; 1-cyclopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1828]; 1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1829]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-neopentylpiperidine-4-carboxamide [1830]; 1-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1831]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1832]; 1-butyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1833]; 1-benzoyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1834]; 1-(2,2-difluoropropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1835]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)azetidine-3-carboxamide [1836]; 1-(2,2-difluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1837]; 1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1838]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [1839]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine-4-carboxamide [1840]; 1-(2-methoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1841]; 1-(2-isopropoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1842]; 1,1-diisobutyl-4-((6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)piperidin-1-ium [1843]; 4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1844]; 4-fluoro-1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1845]; 4-fluoro-1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1846]; (S)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [1847]; (R)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [1848]; (S)-1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [1849]; (R)-1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [1850]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [1851]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-1-yl)acetamide [1852]; 2-(4-fluoropiperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1853]; trans-4-amino-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [1854]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [1855]; (S)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-2-carboxamide [1856]; 2-(4-isobutylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1857]; 2-(3,3-dimethylazetidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1858]; (R)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1859]; (S)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [1860]; 2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1861]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1862]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [1863]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)acetamide [1864]; 2-(4-(difluoromethyl)piperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1865]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [1866]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [1867]; (R)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [1868]; 2-(cyclobutyl(methyl)amino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1869]; 2-(diethylamino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1870]; 7-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-7-azaspiro[3.5]nonane-2-carboxamide [1871]; 4-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperazine-1-carboxamide [1872]; (S)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [1873]; (R)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [1874]; (R)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)pyrrolidine-2-carboxamide [1875]; 2-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [1876]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [1877]; 2-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [1878]; trans-4-(dimethylamino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [1879]; 1-acetyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1880]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [1881]; (S)-1-(2-fluoropropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1882]; (R)-1-(2-fluoropropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1883]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-1-yl)propanamide [1884]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [1885]; 1\u2032-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [1886]; trans-4-(hydroxymethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [1887]; methyl 2-(4-((6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)piperidin-1-yl)acetate [1888]; 1-benzyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1889]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [1890]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-morpholinoacetamide [1891]; (S)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(3-methylmorpholino)acetamide [1892]; (R)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(3-methylmorpholino)acetamide [1893]; (S)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(2-methylmorpholino)acetamide [1894]; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1895]; 2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1896]; 2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1897]; 2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1898]; (S)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-morpholinopropanamide [1899]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(morpholin-2-yl)acetamide [1900]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylmorpholin-2-yl)acetamide [1901]; 2-(4-ethylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1902]; 2-(4-isopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1903]; 2-(4-cyclopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1904]; 2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1905]; (S)-2-(2,4-dimethylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1906]; 1-(2-hydroxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1907]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxamide [1908]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(oxazol-2-ylmethyl)piperidine-4-carboxamide [1909]; (R)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-oxotetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxamide [1910]; (R)-1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)pyrrolidine-2-carboxamide [1911]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)piperidine-4-carboxamide [1912]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(pyrimidin-2-ylmethyl)piperidine-4-carboxamide [1913]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(pyrazin-2-ylmethyl)piperidine-4-carboxamide [1914]; 1-((5-methyl-1,2,4-oxadiazol-3-yl)methyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) piperidine-4-carboxamide [1915]; 1-(2-hydroxy-2-methylpropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1916]; tert-butyl 2-(4-((6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)piperidin-1-yl)acetate [1917]; 2-(4-((6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)piperidin-1-yl)acetic acid [1918]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1919]; tert-butyl (6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)carbamate [1920]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)but-2-ynamide [1921]; trans-4-((6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)cyclohexane-1-carboxylic acid [1922]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-morpholinopropanamide [1923]; trans-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-morpholinocyclobutane-1-carboxamide [1924]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)quinuclidine-4-carboxamide [1925]; 1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)azepane-4-carboxamide [1926]; 2-(4-methoxypiperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1927]; 2-(4-hydroxypiperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1928]; 3-(hydroxymethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)bicyclo[1.1.1]pentane-1-carboxamide [1929]; 1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)azepane-4-carboxamide [1930]; trans-4-(dimethylamino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [1931]; trans-4-(bis(methyl-d3)amino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [1932]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-((4-methylpiperazin-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide [1933]; methyl trans-4-((6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)cyclohexane-1-carboxylate [1934]; 2-(1-isobutylpyrrolidin-3-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [1935]; trans-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-4-(4-methylpiperazine-1-carbonyl) cyclohexane-1-carboxamide [1936]; 1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1937]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(phenylsulfonyl)piperidine-4-carboxamide [1938]; 8-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3,8-diazabicyclo[3.2.1]octane-3-carboxamide [1939]; 3-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxamide [1940]; (1R,3s,5S)-3-amino-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1941]; (1R,3s,5S)\u2014N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-((3,3,3-trifluoropropyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxamide [1942]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [1943]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)morpholine-4-carboxamide [1944]; 4-(dimethylamino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-1-carboxamide [1945]; (S)-2,4-dimethyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperazine-1-carboxamide [1946]; 1-methyl-3-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)urea [1947]; 1-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(1-methylpiperidin-4-yl)urea [1948]; 4-isopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperazine-1-carboxamide [1949]; (R)-3,4-dimethyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)piperazine-1-carboxamide [1950]; N-(6-(1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1951]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(piperazin-1-yl)benzamide [1952]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(4-methylpiperazin-1-yl)benzamide [1953]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(pyrrolidin-1-ylmethyl)benzamide [1954]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(piperidin-4-yloxy)benzamide [1955]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [1956]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [1957]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)benzamide [1958]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(piperazin-1-yl)isonicotinamide [1959]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [1960]; 2-(4-isopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1961]; 2-(4-cyclopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1962]; 2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [1963]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [1964]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-5-(piperidin-4-yloxy)nicotinamide [1965]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-yloxy)isonicotinamide [1966]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-((1-methylpiperidin-4-yl)oxy)isonicotinamide [1967]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-5-(piperidin-4-ylamino)nicotinamide [1968]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-5-((1-methylpiperidin-4-yl)amino)nicotinamide [1969]; 2-(4-aminopiperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1970]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-(methylamino)piperidin-1-yl) isonicotinamide [1971]; 2-(4-(dimethylamino)piperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [1972]; 2-((1-isopropylpiperidin-4-yl)oxy)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [1973]; 2-(3-aminoazetidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1974]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [1975]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-morpholinoisonicotinamide [1976]; 2-((2-(dimethylamino)ethyl)amino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [1977]; 2-(2-(dimethylamino)ethoxy)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1978]; 2-(4-isobutylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1979]; 2-(azetidin-3-yloxy)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1980]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-((1-methylazetidin-3-yl)oxy)isonicotinamide [1981]; 2-(4-ethylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1982]; 4-((dimethylamino)methyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)benzamide [1983]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(1-methylpiperidin-4-yl)benzamide [1984]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-((4-methylpiperazin-1-yl)methyl)benzamide [1985]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1986]; 2-hydroxy-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1987]; 2-isopropoxy-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1988]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(1-methylpiperidin-4-yl)isonicotinamide [1989]; 1\u2032-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [1990]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-(6-(4-methylpiperazin-1-yl) nicotinoyl)piperazin-1-yl)isonicotinamide [1991]; 2-(4-hydroxy-4-methyl-4\u03bb 4 -piperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [1992]; 2-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-6-(4-methylpiperazin-1-yl) isonicotinamide [1993]; 3-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [1994]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1995]; 2-((2S,6R)-2,6-dimethylmorpholino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [1996]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [1997]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [1998]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide [1999]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl) isonicotinamide [2000]; 2-(methyl(1-methylpiperidin-4-yl)amino)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [2001]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-((1-methylpiperidin-4-yl)thio)isonicotinamide [2002]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)pyrimidine-4-carboxamide [2003]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-6-(4-methylpiperazin-1-yl)pyridazine-4-carboxamide [2004]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-6-(4-methylpiperazin-1-yl)pyrimidine-4-carboxamide [2005]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-phenylacetamide [2006]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-phenylpropanamide [2007]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyridin-3-yl)acetamide [2008]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(pyridin-3-yl)propanamide [2009]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyridin-4-yl)acetamide [2010]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(pyridin-4-yl)propanamide [2011]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isoindoline-5-carboxamide [2012]; 2-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)isoindoline-5-carboxamide [2013]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [2014]; 2-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [2015]; 2-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide [2016]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide [2017]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-indole-5-carboxamide [2018]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)benzofuran-5-carboxamide [2019]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)furo[2,3-c]pyridine-5-carboxamide [2020]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)benzo[b]thiophene-5-carboxamide [2021]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)benzofuran-6-carboxamide [2022]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)benzo[d]oxazole-6-carboxamide [2023]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)benzo[d]thiazole-6-carboxamide [2024]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)benzo[d]oxazole-5-carboxamide [2025]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)benzo[d]thiazole-5-carboxamide [2026]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)quinoline-3-carboxamide [2027]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)quinoline-6-carboxamide [2028]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)quinoxaline-6-carboxamide [2029]; 5-chloro-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2030]; 3-chloro-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2031]; 2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [2032]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)isonicotinamide [2033]; 3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2034]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-((4-methylpiperazin-1-yl)methyl) isonicotinamide [2035]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(morpholinomethyl)isonicotinamide [2036]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-ylmethyl)isonicotinamide [2037]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl) acetamide [2038]; 1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-indazole-5-carboxamide [2039]; 1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-benzo[d]imidazole-5-carboxamide [2040]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(piperidin-4-yl)-1H-pyrazole-4-carboxamide [2041]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [2042]; 1-(1-ethylpiperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-pyryrazole-4-carboxamide [2043]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2044]; 1-(1-isopropylpiperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2045]; 1-(1-cyclopropylpiperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2046]; isopropyl 4-(4-((6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)-1H-pyrazol-1-yl) piperidine-1-carboxylate [2047]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [2048]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [2049]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-1,2,3-triazole-4-carboxamide [2050]; 1-(1-isopropylpiperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-1,2,3-triazole-4-carboxamide [2051]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)oxazole-5-carboxamide [2052]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)oxazole-4-carboxamide [2053]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [2054]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [2055]; 2-(1-(2-fluoroethyl)piperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)oxazole-4-carboxamide [2056]; 2-(1-isopropylpiperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)oxazole-4-carboxamide [2057]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)oxazole-4-carboxamide [2058]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)thiazole-5-carboxamide [2059]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-yl)thiazole-4-carboxamide [2060]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)thiazole-4-carboxamide [2061]; 2-(1-(2-fluoroethyl)piperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)thiazole-4-carboxamide [2062]; 2-(1-isopropylpiperidin-4-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)thiazole-4-carboxamide [2063]; 1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl-4-d)piperidine-4-carboxamide [2064]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(2-(methyl-d3)propyl-1,1,2,3,3,3-d 6 )piperidine-4-carboxamide [2065]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d 4 )acetamide [2066]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-(methyl-d 3 )piperazin-1-yl)acetamide [2067]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(morpholino-d 8 )acetamide [2068]; (S)\u2014N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [2069]; 1-isobutyl-N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2070]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [2071]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2072]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-1-yl)acetamide [2073]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2074]; N-(6-(1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-(methyl-d 3 )piperazin-1-yl)isonicotinamide [2075]; N-(6-(1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-(methyl-d 3 )piperazin-1-yl)isonicotinamide [2076]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2077]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-(methyl-d 3 )piperazin-1-yl) isonicotinamide [2078]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(piperidin-4-yl)-1H-pyrazole-4-carboxamide [2079]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [2080]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [2081]; N-(6-(1-(methyl-d 3 )-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [2082]; N-(6-(1-ethyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2083]; N-(6-(1-cyclopropyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2084]; N-(6-(1-cyclopropyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2085]; N-(6-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)cinnolin-3-yl)cyclohexanecarboxamide [2086]; 2-(pyrrolidin-1-yl)-N-(6-(5-(trifluoromethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)acetamide [2087]; N-(6-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2088]; N-(6-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [2089]; N-(6-(5-(azetidin-1-ylmethyl)-1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-4,4-difluorocyclohexane-1-carboxamide [2090]; 4,4-difluoro-N-(6-(1-methyl-5-(pyrrolidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl) cyclohexane-1-carboxamide [2091]; 4,4-difluoro-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl) cyclohexane-1-carboxamide [2092]; 2-(2-fluoroethyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [2093]; tert-butyl 6-((6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)-2-azaspiro[3.3]heptane-2-carboxylate [2094]; 2-fluoro-2-methyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl) propanamide [2095]; 2-(diethylamino)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl) acetamide [2096]; trans-4-methoxy-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl) cyclohexane-1-carboxamide [2097]; trans-4-(hydroxymethyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2098]; (R)\u2014N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)pyrrolidine-2-carboxamide [2099]; 1-isobutyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2100]; N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)-1-(oxetan-3-yl) piperidine-4-carboxamide [2101]; 1-benzoyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2102]; N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [2103]; N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [2104]; N-(6-(1-(difluoromethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2105]; N-(6-(1-ethyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2106]; N-(6-(1-isopropyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(piperidin-4-yloxy)benzamide [2107]; N-(6-(1-isopropyl-1H-pyrazol-4-yl)cinnolin-3-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [2108]; N-(6-(1-isopropyl-1H-pyrazol-4-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [2109]; N-(6-(1-cyclopropyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2110]; 4-fluoro-N-(6-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)cinnolin-3-yl)benzamide [2111]; 4-(difluoromethoxy)-N-(6-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)cinnolin-3-yl)benzamide [2112]; 5-fluoro-N-(6-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)cinnolin-3-yl)nicotinamide [2113]; N 2 -methyl-N 5 -(6-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)cinnolin-3-yl)pyridine-2,5-dicarboxamide [2114]; 1-isopropyl-N-(6-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2115]; 2-methyl-N-(6-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)cinnolin-33-yl)thiazole-5-carboxamide [2116]; N-(6-(5-amino-1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2117]; 4-(difluoromethoxy)-N-(6-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl) benzamide [2118]; N-(6-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2119]; N-(6-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(7-methyl-2,7-diazaspiro [3.5]nonan-2-yl)isonicotinamide [2120]; 4-fluoro-N-(6-(1-methyl-5-(pyrrolidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)benzamide [2121]; 4-fluoro-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)benzamide [2122]; 4-(difluoromethoxy)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)benzamide [2123]; N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)-3-(pyrrolidin-1-ylmethyl)benzamide [2124]; N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [2125]; N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)-2-morpholinoisonicotinamide [2126]; N-(6-(1-methyl-5-(morpholinomethyl)-1H-pyrazol-4-yl)cinnolin-3-yl)-2-morpholinoisonicotinamide [2127]; N-(6-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)-1-((1-(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [2128]; 3,3-difluoro-N-(6-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)cyclobutane-1-carboxamide [2129]; N-((4,4-difluorocyclohexyl)methyl)-6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-amine [2130]; N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [2131]; N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2132]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)acetamide [2133]; (R)\u2014N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)-1-isobutylpiperidine-3-carboxamide [2134]; N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)piperidine-4-carboxamide [2135]; 4-fluoro-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)-1-isobutylpiperidine-4-carboxamide [2136]; N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [2137]; 4-fluoro-N-(6-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)benzamide [2138]; N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)-3-(4-methylpiperazin-1-yl)benzamide [2139]; N 5 -(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)-N 2 -methylpyridine-2,5-dicarboxamide [2140]; N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [2141]; 2-(azetidin-3-yloxy)-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cinnolin-3-yl)isonicotinamide [2142]; N-(6-(1-methyl-1H-pyrazol-5-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2143]; 1-methyl-N-(6-(1-methyl-1H-pyrazol-3-yl)cinnolin-3-yl)piperidine-4-carboxamide [2144]; N-(6-(1-methyl-1H-pyrazol-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2145]; 2-fluoro-2-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)propanamide [2146]; 2,2,3,3-tetramethyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)cyclopropane-1-carboxamide [2147]; trans-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-4-(pyrrolidin-1-yl)cyclohexane-1-carboxamide [2148]; trans-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [2149]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(piperidin-1-yl)acetamide [2150]; 1-ethyl-4-fluoro-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2151]; 4-fluoro-1-isobutyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2152]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2153]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)cyclopropanecarboxamide [2154]; 4,4-difluoro-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2155]; trans-4-(dimethylamino)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2156]; trans-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [2157]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2158]; 1-isobutyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2159]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [2160]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine-4-carboxamide [2161]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [2162]; 1\u2032-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [2163]; (R)\u2014N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [2164]; (R)-1-isobutyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [2165]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2166]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [2167]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)acetamide [2168]; 1-(2-hydroxy-2-methylpropyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2169]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-morpholinoacetamide [2170]; 2-(4-methoxypiperidin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)acetamide [2171]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)morpholine-4-carboxamide [2172]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1-(piperidin-4-yl)-1H-pyrazole-4-carboxamide [2173]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [2174]; 1-(1-ethylpiperidin-4-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2175]; 1-(1-isopropylpiperidin-4-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2176]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [2177]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1H-1,2,3-triazole-4-carboxamide [2178]; 1-(1-isopropylpiperidin-4-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1H-1,2,3-triazole-4-carboxamide [2179]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [2180]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [2181]; 2-(1-isopropylpiperidin-4-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)oxazole-4-carboxamide [2182]; 2-fluoro-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)benzamide [2183]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [2184]; N 2 -methyl-N 5 -(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)pyridine-2,5-dicarboxamide [2185]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [2186]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl) isonicotinamide [2187]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(1-methylpiperidin-4-yl)isonicotinamide [2188]; 2-(4-(dimethylamino)piperidin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl) isonicotinamide [2189]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-morpholinoisonicotinamide [2190]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2191]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl) isonicotinamide [2192]; 2-(4-isopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)isonicotinamide [2193]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-ylamino)isonicotinamide [2194]; 2-(methyl(1-methylpiperidin-4-yl)amino)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)isonicotinamide [2195]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-((1-methylpiperidin-4-yl)thio) isonicotinamide [2196]; 2-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide [2197]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(piperazin-1-yl)isonicotinamide [2198]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetamide [2199]; 1,1-bis(methyl-d 3 )-4-(4-((6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)carbamoyl)pyridin-2-yl)piperazin-1-ium [2200]; N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)cinnolin-3-yl)-2-(4-(methyl-d 3 )piperazin-1-yl) isonicotinamide [2201]; N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2202]; N-(6-(4-methyl-4H-1,2,4-triazol-3-yl)cinnolin-3-yl)-2-morpholinoacetamide [2203]; N-(6-(4-methyl-4H-1,2,4-triazol-3-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2204]; 4-fluoro-1-isobutyl-N-(6-(4-methyl-4H-1,2,4-triazol-3-yl)cinnolin-3-yl)piperidine-4-carboxamide [2205]; N-(6-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)cinnolin-3-yl)-2-morpholinoacetamide [2206]; N-(6-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2207]; N-(6-(1H-1,2,3-triazol-1-yl)cinnolin-3-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [2208]; N-(6-(2H-1,2,3-triazol-2-yl)cinnolin-3-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [2209]; N-(6-(1H-1,2,4-triazol-1-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2210]; 1-isobutyl-N-(6-(1-methyl-1H-tetrazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2211]; 2,2,3,3-tetramethyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)cyclopropane-1-carboxamide [2212]; 4,4-difluoro-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2213]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(piperidin-1-yl)acetamide [2214]; 2-fluoro-2-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)propanamide [2215]; 1-fluoro-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)cyclopropane-1-carboxamide [2216]; 2-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [2217]; 1-fluoro-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2218]; trans-4-methoxy-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2219]; trans-4-(hydroxymethyl)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2220]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)azetidine-3-carboxamide [2221]; (R)\u2014N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)tetrahydrofuran-2-carboxamide [2222]; 1-(2-methoxyethyl)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2223]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2224]; 1-isobutyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2225]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [2226]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [2227]; 2-isopropoxy-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)acetamide [2228]; 3-isopropoxy-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)propanamide [2229]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)cyclopropanecarboxamide [2230]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)cyclohexanecarboxamide [2231]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4,4-difluorocyclohexane-1-carboxamide [2232]; (S)\u2014N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)tetrahydrofuran-2-carboxamide [2233]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-3,3-difluorocyclobutane-1-carboxamide [2234]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-1-fluorocyclopropane-1-carboxamide [2235]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)morpholine-4-carboxamide [2236]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)morpholine-d 8 -4-carboxamide [2237]; 1-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2238]; 1-ethyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2239]; 1-isopropyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2240]; 1-cyclopropyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2241]; 1-isobutyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2242]; 1-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-pyrazole-3-carboxamide [2243]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)acetamide [2244]; 1-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-imidazole-4-carboxamide [2245]; 1-isopropyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-imidazole-4-carboxamide [2246]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazole-4-carboxamide [2247]; 1,2-dimethyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-imidazole-5-carboxamide [2248]; 1-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-1,2,4-triazole-3-carboxamide [2249]; 2-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)oxazole-4-carboxamide [2250]; 2-isopropyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)oxazole-4-carboxamide [2251]; 4-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)oxazole-2-carboxamide [2252]; 4-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)thiazole-2-carboxamide [2253]; 2-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)thiazole-4-carboxamide [2254]; 5-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1,3,4-oxadiazole-2-carboxamide [2255]; 5-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-1,3,4-thiadiazole-2-carboxamide [2256]; 1-isopropyl-N-(6-(1-isopropyl-1H-imidazol-5-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2257]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-1-methyl-1H-pyrazole-4-carboxamide [2258]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-1-isopropyl-1H-pyrazole-4-carboxamide [2259]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-methylthiazole-5-carboxamide [2260]; 4-fluoro-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide [2261]; 4-(difluoromethoxy)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide [2262]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-3-(pyrrolidin-1-ylmethyl)benzamide [2263]; 2-fluoro-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-3,4,5,6-d 4  [2264]; 4-fluoro-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-d 4  [2265]; 2-chloro-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-3,4,5,6-d 4  [2266]; 4-chloro-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-d 4  [2267]; 4-(methyl-d 3 )-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide [2268]; 4-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-d 4  [2269]; 4-(methyl-d 3 )-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-d 4  [2270]; 4-(methoxy-d 3 )-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide [2271]; 4-(methoxy-d 3 )-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-d 4  [2272]; 4-methoxy-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-d 4  [2273]; (E)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide [2274]; (E)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide-2,3-d 2  [2275]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(4-fluorophenyl)acetamide-2,2-d 2  [2276]; (E)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide [2277]; (E)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-3-(phenyl-2,3,4,5,6-d 5 )acrylamide-2,3-d 2  [2278]; 2-(4-fluorophenyl)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)acetamide-2,2-d 2  [2279]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2280]; 2-(dimethylamino)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2281]; 2-(3-aminoazetidin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2282]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)isonicotinamide [2283]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(piperidin-1-yl)isonicotinamide [2284]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-morpholinoisonicotinamide [2285]; 2-(4-isopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2286]; 2-(4-cyclopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2287]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [2288]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [2289]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isoindoline-5-carboxamide [2290]; 2-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isoindoline-5-carboxamide [2291]; 2-(azetidin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2292]; 2-methoxy-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2293]; 2-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2294]; 2-cyano-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2295]; 2-(3,3-difluoroazetidin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2296]; 2-(4,4-difluoropiperidin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2297]; 2-isopropoxy-N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2298]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d 4 )isonicotinamide [2299]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl-d 8 )isonicotinamide [2300]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(piperidin-1-yl-d 10 )isonicotinamide [2301]; N-(6-(1-methyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(morpholino-d 8 )isonicotinamide [2302]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4-isopropoxybenzamide [2303]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [2304]; 4-(benzyloxy)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide [2305]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-fluorobenzamide-3,4,5,6-d 4  [2206]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4-fluorobenzamide-2,3,5,6-d 4  [2307]; 2-chloro-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-3,4,5,6-d 4  [2308]; 4-chloro-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-d 4  [2309]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4-(methyl-d 3 )benzamide [2310]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4-methylbenzamide-2,3,5,6-d 4  [2311]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4-(methyl-d 3 )benzamide-2,3,5,6-d 4  [2312]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4-(methoxy-d 3 )benzamide [2313]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4-(methoxy-d 3 )benzamide-2,3,5,6-d 4  [2314]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-4-methoxybenzamide-2,3,5,6-d 4  [2315]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2316]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-morpholinoisonicotinamide [2317]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)isonicotinamide [2318]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(dimethylamino)isonicotinamide [2319]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d 4 ) isonicotinamide [2320]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl-d 8 )isonicotinamide [2321]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(piperidin-1-yl-d 10 )isonicotinamide [2322]; N-(6-(1,2-dimethyl-1H-imidazol-5-yl)cinnolin-3-yl)-2-(morpholino-d 8 )isonicotinamide [2323]; N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide [2324]; N-(6-(7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl) cyclopropanecarboxamide [2325]; 3,3-difluoro-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)cyclobutane-1-carboxamide [2326]; (R)\u2014N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)pyrrolidine-2-carboxamide [2327]; (R)\u2014N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)piperidine-3-carboxamide [2328]; 1-methyl-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)piperidine-4-carboxamide [2329]; N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)-1-((1-(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [2330]; 1-benzoyl-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)piperidine-4-carboxamide [2331]; 4-fluoro-1-isobutyl-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)piperidine-4-carboxamide [2332]; (R)-2-(2-methylpyrrolidin-1-yl)-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)acetamide [2333]; 2-(cyclobutyl(methyl)amino)-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)acetamide [2334]; 4-fluoro-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)benzamide [2335]; 4-isopropoxy-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)benzamide [2336]; 4-(difluoromethoxy)-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl) benzamide [2337]; 2-((2-(dimethylamino)ethyl)amino)-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)isonicotinamide [2338]; 2-((1-isopropylpiperidin-4-yl)oxy)-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)cinnolin-3-yl)isonicotinamide [2339]; N-(6-(oxazol-5-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2340]; N-(6-(oxazol-5-yl)cinnolin-3-yl)cyclopropanecarboxamide [2341]; (R)\u2014N-(6-(oxazol-5-yl)cinnolin-3-yl)tetrahydrofuran-2-carboxamide [2342]; (R)\u2014N-(6-(oxazol-5-yl)cinnolin-3-yl)piperidine-3-carboxamide [2343]; N-(6-(oxazol-5-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [2344]; N-(6-(oxazol-5-yl)cinnolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [2345]; 1\u2032-methyl-N-(6-(oxazol-5-yl)cinnolin-3-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [2346]; cis-4-morpholino-N-(6-(oxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2347]; 2-(cyclobutyl(methyl)amino)-N-(6-(oxazol-5-yl)cinnolin-3-yl)acetamide [2348]; N-(6-(oxazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2349]; (R)-2-(2-methylpyrrolidin-1-yl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)acetamide [2350]; 2-(4-methylpiperazin-1-yl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)acetamide [2351]; trans-4-((4-methylpiperazin-1-yl)methyl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2352]; 1-(2,2-difluoropropyl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2353]; trans-4-(hydroxymethyl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2354]; trans-4-(methylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2355]; trans-4-((1,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2356]; trans-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-4-((propan-2-yl-1,1,1,3,3,3-d 6 )amino) cyclohexane-1-carboxamide [2357]; trans-4-((2,2-difluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2358]; trans-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-4-((3,3,3-trifluoropropyl)amino)cyclohexane-1-carboxamide [2359]; trans-4-((2-methoxyethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2360]; trans-4-(dimethylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2361]; trans-4-(bis(methyl-d 3 )amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2362]; cis-4-(dimethylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2363]; trans-4-((2,2-difluoroethyl)(methyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl) cyclohexane-1-carboxamide [2364]; trans-4-(methyl(oxetan-3-yl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2365]; trans-4-((2-fluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2366]; trans-4-(2-(fluoromethyl)aziridin-1-yl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2367]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2368]; trans-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-3-morpholinocyclobutane-1-carboxamide [2369]; trans-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [2370]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-2-(piperidin-1-yl)acetamide [2371]; 2-(4-methoxypiperidin-1-yl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)acetamide [2372]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [2373]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)morpholine-4-carboxamide [2374]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-2-morpholinoacetamide [2375]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-3-morpholinopropanamide [2376]; 1-methyl-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2377]; 1-(2,2-difluoropropyl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2378]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-4-morpholinopiperidine-1-carboxamide [2379]; 4-((1,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2380]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2381]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2382]; 4-(dimethylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2383]; 4-((2,2-difluoroethyl)(methyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2384]; (3S,4S)-4-amino-3-fluoro-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2385]; (3S,4S)-3-fluoro-4-(methylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2386]; (3R,4R)-4-amino-3-fluoro-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2387]; (3R,4R)-3-fluoro-4-(methylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2388]; 4-((2-fluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2389]; 4-((2,2-difluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2390]; (1R,3s,5S)-3-amino-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2391]; (1R,3r,5S)-3-amino-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2392]; (1R,3r,5S)-3-((2-fluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2393]; (1R,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2394]; (1R,3s,5S)\u2014N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-3-((3,3,3-trifluoropropyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxamide [2395]; (3S,4S)-3-fluoro-4-(isopropylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2396]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [2397]; 2-methyl-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [2398]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-2-(morpholino-d 8 )acetamide [2399]; trans-N-(6-(2-methyloxazol-4-yl)cinnolin-3-yl)-4-(4-methylpiperazin-1-yl)cyclohexane-1-carboxamide [2400]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [2401]; 2-(1H-imidazol-1-yl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)acetamide [2402]; 4-(difluoromethoxy)-N-(6-(oxazol-5-yl)cinnolin-3-yl)benzamide [2403]; 3-((1-methylpiperidin-4-yl)oxy)-N-(6-(oxazol-5-yl)cinnolin-3-yl)benzamide [2404]; N-(6-(oxazol-5-yl)cinnolin-3-yl)isonicotinamide [2405]; 2-(3-aminoazetidin-1-yl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)isonicotinamide [2406]; 2-(1-methylpiperidin-4-yl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)isonicotinamide [2407]; 1\u2032-methyl-N-(6-(oxazol-5-yl)cinnolin-3-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [2408]; 2-(4-methylpiperazin-1-yl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)isonicotinamide [2409]; 2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)isonicotinamide [2410]; N-(6-(oxazol-5-yl)cinnolin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide [2411]; N-(6-(oxazol-5-yl)cinnolin-3-yl)-2-(piperidin-4-ylamino)isonicotinamide [2412]; 2-methyl-N-(6-(oxazol-5-yl)cinnolin-3-yl)isoindoline-5-carboxamide [2413]; N-(6-(oxazol-5-yl)cinnolin-3-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [2414]; N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2415]; N-(6-(3-methylisoxazol-5-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2416]; 4-fluoro-1-isobutyl-N-(6-(5-methyl-1,3,4-oxadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2417]; 1-isobutyl-N-(6-(5-methyl-1,3,4-oxadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2418]; N-(6-(5-(dimethylamino)-1,3,4-oxadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2419]; N-(6-(5-(dimethylamino)-1,3,4-oxadiazol-2-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2420]; N-(6-(5-methyl-1,3,4-oxadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2421]; 3,3-difluoro-N-(6-(thiazol-5-yl)cinnolin-3-yl)cyclobutane-1-carboxamide [2422]; 2-methyl-N-(6-(thiazol-5-yl)cinnolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [2423]; 1-fluoro-N-(6-(thiazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2424]; trans-4-(dimethylamino)-N-(6-(thiazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2425]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2426]; N-(6-(thiazol-5-yl)cinnolin-3-yl)azetidine-3-carboxamide [2427]; 1-methyl-N-(6-(thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2428]; 1-(2,2-difluoropropyl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2429]; 1-(oxetan-3-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2430]; 1-(2-(pyrrolidin-1-yl)acetyl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2431]; 1\u2032-methyl-N-(6-(thiazol-5-yl)cinnolin-3-yl)-[1,4\u2032-bipiperidine]-4-carboxamide [2432]; 2-(pyrrolidin-1-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)propanamide [2433]; 2-(piperidin-1-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)acetamide [2434]; 2-(4-methylpiperazin-1-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)acetamide [2435]; 2-morpholino-N-(6-(thiazol-5-yl)cinnolin-3-yl)acetamide [2436]; 4-(piperidin-4-yloxy)-N-(6-(thiazol-5-yl)cinnolin-3-yl)benzamide [2437]; N-(6-(thiazol-5-yl)cinnolin-3-yl)isonicotinamide [2438]; 6-(4-methylpiperazin-1-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)nicotinamide [2439]; 1\u2032-methyl-N-(6-(thiazol-5-yl)cinnolin-3-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [2440]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)isonicotinamide [2441]; 2-(4-(dimethylamino)piperidin-1-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)isonicotinamide [2442]; 2-(4-methylpiperazin-1-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)isonicotinamide [2443]; 2-((1-methylpiperidin-4-yl)thio)-N-(6-(thiazol-5-yl)cinnolin-3-yl)isonicotinamide [2444]; N-(6-(thiazol-5-yl)cinnolin-3-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide [2445]; trans-4-((1,3-difluoropropan-2-yl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) cyclohexane-1-carboxamide [2446]; N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)morpholine-4-carboxamide [2447]; N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2448]; 2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)acetamide [2449]; N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)-2-morpholinoacetamide [2450]; N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)-2-(morpholino-d 8 )acetamide [2451]; 2-(4-methylpiperazin-1-yl)-N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)acetamide [2452]; 1-methyl-N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2453]; N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)isonicotinamide [2454]; N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)nicotinamide [2455]; 2-(4-methylpiperazin-1-yl)-N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)isonicotinamide [2456]; trans-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [2457]; trans-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(4-methylpiperazin-1-yl) cyclohexane-1-carboxamide [2458]; 4-isopropyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperazine-1-carboxamide [2459]; 4-((2-methoxyethyl)(methyl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) piperidine-1-carboxamide [2460]; 4-((1,3-difluoropropan-2-yl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) piperidine-1-carboxamide [2461]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-((3,3,3-trifluoropropyl)amino)piperidine-1-carboxamide [2462]; 4-((2-fluoroethyl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-1-carboxamide [2463]; (3R,4S)-4-amino-3-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-1-carboxamide [2464]; (3R,4R)-4-amino-3-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-1-carboxamide [2465]; (3S,4S)-3-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(methylamino)piperidine-1-carboxamide [2466]; (3R,4R)-3-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(methylamino) piperidine-1-carboxamide [2467]; 4-amino-3,3-difluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-1-carboxamide [2468]; (3R,4R)-3-fluoro-4-(isopropylamino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) piperidine-1-carboxamide [2469]; (3R,4S)-3-fluoro-4-(isopropylamino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) piperidine-1-carboxamide [2470]; 3,3-difluoro-4-(isopropylamino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-1-carboxamide [2471]; (3S,4S)-3-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-((propan-2-yl-1,1,1,3,3,3-d 6 )amino)piperidine-1-carboxamide [2472]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2473]; (1R,3s,5S)-3-((1,3-difluoropropan-2-yl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2474]; 4-(dimethylamino)-N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)piperidine-1-carboxamide [2475]; 4-((2,2-difluoroethyl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-1-carboxamide [2476]; 4-((2,2-difluoroethyl)(methyl-d 3 )amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-1-carboxamide [2477]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-morpholinopiperidine-1-carboxamide [2478]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(4-methylpiperazin-1-yl)piperidine-1-carboxamide [2479]; (R)-3,4-dimethyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperazine-1-carboxamide [2480]; (S)-3,4-dimethyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperazine-1-carboxamide [2481]; (1R,3r,5S)-3-((2-fluoroethyl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2482]; (1R,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2483]; (1R,3r,5S)-3-amino-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [2484]; (1S,4S)-5-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxamide [2485]; (1R,4R)-5-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxamide [2486]; 8-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-3,8-diazabicyclo[3.2.1]octane-3-carboxamide [2487]; 3-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxamide [2488]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [2489]; 2-(4-methylpiperazin-1-yl)-N-(6-(5-methylthiazol-2-yl)cinnolin-3-yl)isonicotinamide [2490]; 2-(4-methylpiperazin-1-yl)-N-(6-(4-methylthiazol-2-yl)cinnolin-3-yl)isonicotinamide [2491]; N-(6-(2-(methylamino)thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2492]; 1-methyl-N-(6-(2-(methylamino)thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2493]; N-(6-(2-(diethylamino)thiazol-5-yl)cinnolin-3-yl)-2-(4-fluoropiperidin-1-yl)acetamide [2494]; N-(6-(2-(diethylamino)thiazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [2495]; N-(6-(2-aminothiazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2496]; N-(6-(2-(methylamino)thiazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2497]; N-(6-(2-(dimethylamino)thiazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2498]; 2-(4-isopropylpiperazin-1-yl)-N-(6-(2-(methylamino)thiazol-5-yl)cinnolin-3-yl)isonicotinamide [2499]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(6-(2-(methylamino)thiazol-5-yl)cinnolin-3-yl) isonicotinamide [2500]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(6-(2-(dimethylamino)thiazol-5-yl)cinnolin-3-yl) isonicotinamide [2501]; 2-(3-aminoazetidin-1-yl)-N-(6-(2-(dimethylamino)thiazol-5-yl)cinnolin-3-yl)isonicotinamide [2502]; N-(6-(5-chlorothiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2503]; 2-(3-(2-(4-methylpiperazin-1-yl)isonicotinamido)cinnolin-6-yl)thiazole-5-carboxamide [2504]; N-(6-(isothiazol-4-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2505]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(difluoromethoxy)benzamide [2506]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [2507]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-((1-methylpiperidin-4-yl)oxy)benzamide [2508]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [2509]; N 5 -(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-N 2 -methylpyridine-2,5-dicarboxamide [2510]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-6-(4-methylpiperazin-1-yl)nicotinamide [2511]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-1\u2032-methyl-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [2512]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(3-(dimethylamino)azetidin-1-yl)isonicotinamide [2513]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2514]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(4-isopropylpiperazin-1-yl)isonicotinamide [2515]; N-(6-(1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-morpholinoisonicotinamide [2516]; 1-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2517]; trans-4-methoxy-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2518]; cis-4-methoxy-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2519]; trans-4-amino-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2520]; trans-4-(dimethylamino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2521]; trans-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [2522]; trans-4-(hydroxymethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2523]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2524]; 4-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2525]; 1-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2526]; 4-fluoro-1-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2527]; 1-(2-fluoroethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2528]; 1-(2,2-difluoroethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2529]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2530]; 1-(2,2-difluoropropyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2531]; 1-benzoyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2532]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2533]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(piperidin-1-yl)acetamide [2534]; 2-(4-methoxypiperidin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)acetamide [2535]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [2536]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-morpholinoacetamide [2537]; (R)\u2014N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(3-methylmorpholino)acetamide [2538]; 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)acetamide [2539]; 2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)acetamide [2540]; 2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)acetamide [2541]; 2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)acetamide [2542]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(1,4-oxazepan-4-yl)acetamide [2543]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-morpholinoacetamide-2,2-d 2  [2544]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(morpholino-d 8 )acetamide [2545]; 1-methyl-3-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)urea [2546]; (3S,4S)-4-amino-3-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-1-carboxamide [2547]; (3S,4S)-4-(dimethylamino)-3-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) piperidine-1-carboxamide [2548]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)morpholine-4-carboxamide [2549]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(methylamino)piperidine-1-carboxamide [2550]; 4-(dimethylamino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-1-carboxamide [2551]; 4-((2,2-difluoroethyl)(methyl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) piperidine-1-carboxamide [2552]; (3S,4S)-3-fluoro-4-(isopropylamino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) piperidine-1-carboxamide [2553]; 2-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxamide [2554]; 4-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperazine-1-carboxamide [2555]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [2556]; 1-(1-isopropylpiperidin-4-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2557]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [2558]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [2559]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [2560]; 2-(3-(dimethylamino)azetidin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)isonicotinamide [2561]; 1\u2032-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [2562]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2563]; 2-(methyl(1-methylpiperidin-4-yl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) isonicotinamide [2564]; 2-(azetidin-3-yloxy)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)isonicotinamide [2565]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-3-((1-methylpiperidin-4-yl)oxy)benzamide [2566]; N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-((1-methylpiperidin-4-yl)thio) isonicotinamide [2567]; 6-(4-methylpiperazin-1-yl)-N-(6-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) nicotinamide [2568]; 2-(4-methylpiperazin-1-yl)-N-(6-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)cinnolin-3-yl) isonicotinamide [2569]; N-(6-(5-amino-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2570]; N-(6-(5-(dimethylamino)-1,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2571]; N-(6-(3-amino-5-fluorophenyl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2572]; N-(6-(3-fluoro-5-(isopropylamino)phenyl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2573]; 1-methyl-N-(6-(pyridin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2574]; 2-(4-methylpiperazin-1-yl)-N-(6-(pyridin-2-yl)cinnolin-3-yl)isonicotinamide [2575]; 2-(4-methylpiperazin-1-yl)-N-(6-(pyridin-4-yl)cinnolin-3-yl)isonicotinamide [2576]; N-(6-(pyridin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide [2577]; N-(6-(pyridin-3-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2578]; 1-methyl-N-(6-(pyridin-3-yl)cinnolin-3-yl)piperidine-4-carboxamide [2579]; N-(6-(pyridin-3-yl)cinnolin-3-yl)quinuclidine-4-carboxamide [2580]; 2-morpholino-N-(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2581]; 2-(morpholino-d 8 )-N-(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2582]; 2-(4-methylpiperazin-1-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2583]; 2-(4-methyl-1,4-diazepan-1-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2584]; 2-(4-methylpiperazin-1-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)isonicotinamide [2585]; 2-(2-methyl-1H-imidazol-1-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2586]; 2-(1H-imidazol-1-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2587]; 2-(piperidin-4-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)oxazole-4-carboxamide [2588]; 2-(1-methylpiperidin-4-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)oxazole-4-carboxamide [2589]; 2-(1-isopropylpiperidin-4-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)oxazole-4-carboxamide [2590]; trans-N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-3-morpholinocyclobutane-1-carboxamide [2591]; trans-N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)cyclohexane-1-carboxamide [2592]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2593]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2594]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [2595]; N-(6-(6-fluoropyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [2596]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-morpholinoacetamide [2597]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-3-morpholinopropanamide [2598]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2599]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [2600]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(1-methylpiperidin-4-yl)oxazole-4-carboxamide [2601]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(1-isopropylpiperidin-4-yl)oxazole-4-carboxamide [2602]; N-(6-(5-chloropyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2603]; N-(6-(5-methylpyridin-3-yl)cinnolin-3-yl)-2-morpholinoacetamide [2604]; N-(6-(5-(difluoromethyl)pyridin-3-yl)cinnolin-3-yl)-3-(piperidin-4-yl)benzamide [2605]; N-(6-(5-(difluoromethyl)pyridin-3-yl)cinnolin-3-yl)-3-(1-methylpiperidin-4-yl)benzamide [2606]; N-(6-(5-(difluoromethyl)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2607]; 2-(4-methylpiperazin-1-yl)-N-(6-(5-(trifluoromethyl)pyridin-3-yl)cinnolin-3-yl)acetamide [2608]; 2-(4-methylpiperazin-1-yl)-N-(6-(6-(trifluoromethyl)pyridin-3-yl)cinnolin-3-yl)acetamide [2609]; N-(6-(5-(hydroxymethyl)pyridin-3-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2610]; N-(6-(5-cyanopyridin-3-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2611]; N-(6-(5-methoxypyridin-3-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2612]; N-(6-(5-methoxypyridin-3-yl)cinnolin-3-yl)-2-morpholinoacetamide [2613]; N-(6-(5-methoxypyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2614]; 4-fluoro-N-(6-(5-(piperidin-4-yloxy)pyridin-3-yl)cinnolin-3-yl)benzamide [2615]; N-(6-(5-aminopyridin-3-yl)cinnolin-3-yl)-4-fluorobenzamide [2616]; N-(6-(5-aminopyridin-3-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [2617]; N-(6-(5-aminopyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2618]; N-(6-(5-aminopyridin-3-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [2619]; N-(6-(6-aminopyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2620]; N-(6-(6-(methylamino)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2621]; N-(6-(5-(isopropylamino)pyridin-3-yl)cinnolin-3-yl)-3-(piperidin-4-yl)benzamide [2622]; N-(6-(5-(isopropylamino)pyridin-3-yl)cinnolin-3-yl)-3-(1-methylpiperidin-4-yl)benzamide [2623]; N-(6-(5-(isopropylamino)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2624]; N-(6-(5-(piperidin-4-ylamino)pyridin-3-yl)cinnolin-3-yl)cyclohexanecarboxamide [2625]; 4-fluoro-N-(6-(5-(piperidin-4-ylamino)pyridin-3-yl)cinnolin-3-yl)benzamide [2626]; 4-fluoro-N-(6-(5-((1-methylpiperidin-4-yl)amino)pyridin-3-yl)cinnolin-3-yl)benzamide [2627]; N-(6-(5-acetamidopyridin-3-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2628]; N-(6-(5-(dimethylamino)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2629]; N-(6-(6-(dimethylamino)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2630]; 1-methyl-N-(6-(5-(pyrrolidin-1-yl)pyridin-3-yl)cinnolin-3-yl)piperidine-4-carboxamide [2631]; N-(6-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide [2632]; 4-fluoro-N-(6-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)cinnolin-3-yl)benzamide [2633]; N-(6-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide [2634]; 4-fluoro-N-(6-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)cinnolin-3-yl)benzamide [2635]; N-(6-(5-(piperazin-1-ylmethyl)pyridin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide [2636]; N-(6-(5-((4-methylpiperazin-1-yl)methyl)pyridin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide [2637]; N-(6-(5-(morpholinomethyl)pyridin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide [2638]; N-methyl-5-(3-(1-methylpiperidine-4-carboxamido)cinnolin-6-yl)nicotinamide [2639]; N-methyl-5-(3-(2-(4-methylpiperazin-1-yl)isonicotinamido)cinnolin-6-yl)nicotinamide [2640]; N-(6-(pyridin-3-yl-d 4 )cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2641]; 2-(4-methylpiperazin-1-yl)-N-(6-(pyridin-3-yl-d 4 )cinnolin-3-yl)acetamide [2642]; 2-morpholino-N-(6-(pyridin-3-yl-d 4 )cinnolin-3-yl)acetamide [2643]; 1-methyl-N-(6-(2-methylpyrimidin-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2644]; 2-(4-methylpiperazin-1-yl)-N-(6-(2-methylpyrimidin-5-yl)cinnolin-3-yl)isonicotinamide [2645]; N-(6-(2-aminopyrimidin-5-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2646]; 2-morpholino-N-(6-(pyridazin-3-yl)cinnolin-3-yl)acetamide [2647]; 2-morpholino-N-(6-(pyridazin-4-yl)cinnolin-3-yl)acetamide [2648]; N-(6-(pyridazin-4-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2649]; trans-3-morpholino-N-(6-(pyrazin-2-yl)cinnolin-3-yl)cyclobutane-1-carboxamide [2650]; trans-4-(dimethylamino)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2651]; trans-4-morpholino-N-(6-(pyrazin-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2652]; trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2653]; trans-4-((4-methylpiperazin-1-yl)methyl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2654]; N-(6-(pyrazin-2-yl)cinnolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [2655]; 1-methyl-N-(6-(pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2656]; 4-fluoro-1-methyl-N-(6-(pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2657]; 1-(2-fluoroethyl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2658]; 1-(oxetan-3-yl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2659]; 2-morpholino-N-(6-(pyrazin-2-yl)cinnolin-3-yl)acetamide [2660]; 1-methyl-N-(6-(pyrazin-2-yl)cinnolin-3-yl)azepane-4-carboxamide [2661]; 1-isobutyl-N-(6-(pyrazin-2-yl)cinnolin-3-yl)azepane-4-carboxamide [2662]; 1-(2-hydroxy-2-methylpropyl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)azepane-4-carboxamide [2663]; 4-(morpholinomethyl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)benzamide [2664]; 2-(4-methylpiperazin-1-yl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)isonicotinamide [2665]; N-(6-(6-(methylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2666]; N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)azetidine-3-carboxamide [2667]; N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2668]; N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-1-methylpiperidine-4-carboxamide [2669]; 1-(2-fluoroethyl)-N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2670]; 1-isopropyl-N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2671]; 1-isopentyl-N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2672]; N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-3-(piperidin-4-yl)benzamide [2673]; N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-3-(1-methylpiperidin-4-yl)benzamide [2674]; N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [2675]; 1-(1-(2-fluoroethyl)piperidin-4-yl)-N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-1H-1,2,3-triazole-4-carboxamide [2676]; N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-1-(1-isopropylpiperidin-4-yl)-1H-1,2,3-triazole-4-carboxamide [2677]; N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2678]; N-(6-(6-(tert-butylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(3-(dimethylamino)azetidin-1-yl) isonicotinamide [2679]; N-(6-(6-(tert-butylamino)pyrazin-2-yl)cinnolin-3-yl)-1\u2032-methyl-1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-[2,4\u2032-bipyridine]-4-carboxamide [2680]; N-(6-(6-(tert-butylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2681]; N-(6-(6-(tert-butylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-isopropylpiperazin-1-yl) isonicotinamide [2682]; N-(6-(6-(tert-butylamino)pyrazin-2-yl)cinnolin-3-yl)-2-morpholinoisonicotinamide [2683]; N-(6-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)cinnolin-3-yl) cyclopropanecarboxamide [2684]; 4-fluoro-N-(6-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)cinnolin-3-yl)benzamide [2685]; N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)cyclobutanecarboxamide [2686]; 3,3-difluoro-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)cyclobutane-1-carboxamide [2687]; N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)cyclopentanecarboxamide [2688]; 4,4-difluoro-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)cyclohexane-1-carboxamide [2689]; N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [2690]; 4-fluoro-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)benzamide [2691]; N-(6-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl) cyclopropanecarboxamide [2692]; 4-fluoro-N-(6-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)benzamide [2693]; N-(6-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)cyclobutanecarboxamide [2694]; N-(6-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)cyclopentanecarboxamide [2695]; 4-fluoro-N-(6-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)benzamide [2696]; N-(6-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)cyclopropanecarboxamide [2697]; 3,3-difluoro-N-(6-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)cyclobutane-1-carboxamide [2698]; N-(6-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)cyclopentanecarboxamide [2699]; 4-fluoro-N-(6-(6-((1-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)benzamide [2700]; N-(6-(6-(dimethylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2701]; N-(6-(6-(diethylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2702]; N-(6-(6-(3-aminoazetidin-1-yl)pyrazin-2-yl)cinnolin-3-yl)-4-fluorobenzamide [2703]; 2-(4-methylpiperazin-1-yl)-N-(6-(6-(pyrrolidin-1-yl)pyrazin-2-yl)cinnolin-3-yl)isonicotinamide [2704]; N-(6-(6-(azetidin-3-ylmethoxy)pyrazin-2-yl)cinnolin-3-yl)-4-fluorobenzamide [2705]; N-(6-(6-(azetidin-3-yloxy)pyrazin-2-yl)cinnolin-3-yl)-4-fluorobenzamide [2706]; N-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [2707]; N-(6-(1H-pyrrolo[3,2-b]pyridin-6-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [2708]; N-(6-(1H-pyrrolo[2,3-c]pyridin-4-yl)cinnolin-3-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide [2709]; N-(6-(1H-pyrrolo[2,3-b]pyridin-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2710]; N-(6-(1H-pyrrolo[3,2-b]pyridin-6-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2711]; N-(6-(1H-pyrrolo[2,3-c]pyridin-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2712]; 2-(4-methylpiperazin-1-yl)-N-(6-(oxazolo[5,4-b]pyridin-6-yl)cinnolin-3-yl)isonicotinamide [2713]; N-(6-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2714]; N-(6-(3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2715]; N-(6-(2-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl) isonicotinamide [2716]; N-(6-(5H-pyrrolo[2,3-b]pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2717]; N-(6-(5H-pyrrolo[2,3-b]pyrazin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-1-yl)isonicotinamide [2718]; 1-isopropyl-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2719]; 1-isopropyl-N-(6-(6-((1-methylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)-1H-pyrazole-4-carboxamide [2720]; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 97.0
- Lexical Diversity: 1.45902
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15498990', '15749587', '15749923', '15749910', '15749922']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8237153045242501
- 35 USC 102 Novelty (BERT): 0.5991256949046567
- Combined Prediction Score: 0.8012563435622908
- Mean Citation Score: 444.7209820000001
- Max Citation Score: 527.2941
- Similarity Product: 477.65545417508486

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test