PATENT CLAIM ANALYSIS

Application Number: 15751163
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["546", "115000"]

Abstract:
The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases.

Claim (Index 5):
The compound of  claim 1 , wherein\n R 1  is one of the following sub-formulae: \u2003wherein each R is independently and optionally substituted with 1, 2, 3, 4 or 5 R 1a  which are the same or different: each R 1a  is independently H, ethyl, methyl, n-propyl, i-propyl, n-butyl, t-butyl, cyano, trifluoromethyl, 2,2-difluoroethyl, 3,3,3-trifluoropropyl, F, Cl, Br, oxo (\u2550O), methoxy, n-propoxy, ethoxy, t-butoxy, 2-methylpropoxy, i-propoxy, \u2014SR 14 , \u2014OR 14 , \u2014SO 2 \u2014N(R 13 )(R 13a ), \u2014N(R 13a )\u2014SO 2 \u2014R 14 , \u2014N(R 13 )(R 13a ), \u2014C(\u2550O)\u2014C(\u2550O)\u2014N(R 13 )(R 13a ), \u2014C(\u2550O)\u2014N(R 13 )(R 13a ), \u2014C(\u2550N\u2014OH)(R 14a ), \u2014N(R 13 )\u2014C(\u2550O)R 14a , \u2014C(\u2550O)\u2014OR 14 , \u2014C(\u2550O)\u2014R 14a , \u2014SO 2 R 14 , or one of the following sub-formulae: wherein each R 1a  is independently and optionally substituted with 1, 2, 3, 4 or 5 R 1b  which are the same or different; each R 1b  is independently H, methyl, ethyl, n-propyl, i-propyl, n-butyl, t-butyl, cyclobutyl, cyclopropyl, cyclohexyl, cyclopentyl, C 1-4  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, methoxy, F, Cl, Br, nitro, cyano, hydroxy, oxo (\u2550O), \u2014OR 15 , \u2014SO 2 R 15 , \u2014N(R 16 )(R 16a ), \u2014C(\u2550O)\u2014N(R 16 )(R 16a ), or one of the following sub-formulae: wherein each R 1b  is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from hydroxy, nitro, cyano, methyl, ethyl, n-propyl, i-propyl, n-butyl, t-butyl, C 1-4  haloalkyl, F, Cl, Br, oxo (\u2550O), C 1-4  alkoxy, phenyl, pyridyl, thiazolyl, thienyl, diazolyl, triazolyl, tetrazolyl, epoxypropyl, tetrahydrofuryl, tetrahydropyranyl, morpholinyl, piperdyl, cyclobutyl, cyclopentyl, dioxanyl, cyclohexyl and amino; each R 16  and R 16a  is independently H, C 1-4  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, phenyl, \u2014SO 2 R 17 , \u2014N(R 18 )(R 18a ), C 1-4  haloalkyl, cyclopropyl, cyclohexyl, each R 15 , R 13 , R 13a , R 14 , R 14a , R 17 , R 18  and R 18a  is independently H, methyl, ethyl, n-propyl, i-propyl, n-butyl, 2-methylpropyl, t-butyl, trifluoromethyl, difluoromethyl, 2,2-difluoroethyl, 3,3,3-trifluoropropyl, phenyl, cyclopropyl, cyclohexyl, \u2003wherein each sub-formula is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from F, Cl, Br, cyano, hydroxy, trifluoromethyl, C 1-4  alkyl, C 1-4  alkoxy and 2,2-difluoroethyl.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.42222
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12734224', '14647445', '14397200', '15580978', '14894817']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8211150288062288
- 35 USC 102 Novelty (BERT): 0.5302208921050034
- Combined Prediction Score: 0.7920256151361063
- Mean Citation Score: 341.089354
- Max Citation Score: 366.94565
- Similarity Product: 287.2189250741303

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test