PATENT CLAIM ANALYSIS

Application Number: 15914050
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["536", "028520"]

Abstract:
Described herein are 5-position modified cytosine nucleotides and nucleosides as well as phosphoramidites and triphosphates derivatives thereof. Further provided are methods of making and using the same, and compositions and uses of the modified nucleosides as part of a nucleic acid molecule (e.g., aptamer).

Claim (Index 1):
A compound comprising the structure shown in Formula I: wherein\n R is independently a \u2014(CH 2 ) n \u2014, wherein n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; \n R X1  comprises \n * denotes the point of attachment of the R X1  group to the \u2014(CH 2 ) n \u2014 group; and R X4  is independently selected from the group consisting of a branched or linear lower alkyl (C1-C20); a hydroxyl group; a halogen (F, Cl, Br, I); nitrile (CN); boronic acid (BO 2 H 2 ); carboxylic acid (COOH); carboxylic acid ester (COOR X2 ); primary amide (CONH 2 ); secondary amide (CONHR X2 ); tertiary amide (CONR X2 R X3 ); sulfonamide (SO 2 NH 2 ); N-alkylsulfonamide (SONHR X2 ); R X2  and R X3  are independently, for each occurrence, selected from the group consisting of a branched or linear lower alkyl (C1-C20); phenyl (C 6 H 5 ); an R X4  substituted phenyl ring (R X4 C 6 H 4 ), wherein R X4  is defined above; a carboxylic acid (COOH); a carboxylic acid ester (COOR X5 ), wherein R X5  is a branched or linear lower alkyl (C1-C20); and cycloalkyl, wherein R X2 \u2550R X3 \u2550(CH 2 ) n ; X is independently selected from the group consisting of \u2014H, \u2014OH, \u2014OMe, \u2014O-allyl, \u2014F, \u2014OEt, \u2014OPr, \u2014OCH 2 CH 2 OCH 3  and -azido; R\u2032 is independently selected from the group consisting of a \u2014H, \u2014OAc; \u2014OBz; \u2014P(NiPr 2 )(OCH 2 CH 2 CN); and \u2014OSiMe 2 tBu; R\u2033 is independently selected from the group consisting of a hydrogen, 4,4\u2032-dimethoxytrityl (DMT) and triphosphate (\u2014P(O)(OH)\u2014O\u2014P(O)(OH)\u2014O\u2014P(O)(OH) 2 ) or a salt thereof; and salts thereof.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 90.0
- Lexical Diversity: 1.38889
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14917056', '15650281', '14069798', '14552853', '14216486']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.589050646588521
- 35 USC 102 Novelty (BERT): 0.6294015988912521
- Combined Prediction Score: 0.5930857418187943
- Mean Citation Score: 367.984386
- Max Citation Score: 565.87
- Similarity Product: 562.6427578157187

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test