PATENT CLAIM ANALYSIS

Application Number: 15949769
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["530", "317000"]

Abstract:
Provided is a cyclic peptide, which is represented by Formula (I) or Formula (I′) and has excellent antibody binding properties and improved chemical resistance, an affinity chromatography support, a labeled antibody, an antibody drug conjugate, and a pharmaceutical preparation. R N -X g -[X i -X a -X m -X 2 -X 3 -X n -X b -X j ] k -X h -R C   (I) In Formula (I), X a  and X b  each independently represent an amino acid residue derived from an amino acid, other than L-cysteine and D-cysteine, having a thiol group on a side chain and are bonded to each other through a disulfide bond, or, one of X a  and X b  represents an amino acid residue derived from an amino acid, other than L-cysteine and D-cysteine, having a thiol group on a side chain and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and X a  and X b  are bonded to each other through a thioether bond. R N -X g -[X i -X a -X m -X 1 -X 2 -X 3 -X n -X b -X j ] k -X h -R C   (I′) In Formula (I′), one of X a  and X b  represents an amino acid residue derived from L-cysteine or D-cysteine and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and X a  and X b  are bonded to each other through a thioether bond, or, one of X a  and X b  represents an amino acid residue derived from L-penicillamine or D-penicillamine and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and X a  and X b  are bonded to each other through a thioether bond.

Claim (Index 1):
A cyclic peptide represented by Formula (I),\n R N -X g -[X i -X a -X m -X 2 -X 3 -X n -X b -X j ] k -X h -R C \u2003\u2003(I): in Formula (I), R N  represents an N-terminal group; R C  represents a C-terminal group; X 1  represents an L-leucine residue, an L-isoleucine residue, an L-methionine residue, an L-lysine residue, or an L-arginine residue; X 2  represents an L-valine residue or an L-isoleucine residue; X 3  represents an L-tryptophan residue; X a  and X b  each independently represent an amino acid residue derived from an amino acid, other than L-cysteine and D-cysteine, having a thiol group on a side chain, and are bonded to each other through a disulfide bond, or, one of X a  and X b  represents an amino acid residue derived from an amino acid, other than L-cysteine and D-cysteine, having a thiol group on a side chain, and the other represents an amino acid residue derived from an amino acid having a haloacetyl group on a side chain, and X a  and X b  are bonded to each other through a thioether bond; X g , X h , X i , X j , X m , and X n  each represent g consecutive X's, h consecutive X's, i consecutive X's, j consecutive X's, m consecutive X's, and n consecutive X's; X represents an amino acid residue, and in a case where there is a plurality of X's, the plurality of X's may be the same as or different from each other; g, h, i, and j each independently represent an integer equal to or greater than 0; m and n are integers satisfying 0\u2264m\u22649, 0\u2264n\u22649, and 3\u2264m+n\u22649 simultaneously; and k is an integer equal to or greater than 1, and in a case where k\u22642, X 1 , X 2 , X 3 , X a , X b , X i , X j , X m , and X n  in a repeating unit [X i -X a -X m -X 1 -X 2 -X 3 -X n -X b -X j ] each may be the same or different between the repeating units.

Metadata:
- Claim Count in Document: 31.0
- Percentile: 91.0
- Lexical Diversity: 4.04598
- Patent Class: 530.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14240083', '13258663', '11721910', '13990123', '14358816']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7171225701475246
- 35 USC 102 Novelty (BERT): 0.5072918212681394
- Combined Prediction Score: 0.6961394952595861
- Mean Citation Score: 253.962472
- Max Citation Score: 275.18484
- Similarity Product: 195.0020914546681

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test