PATENT CLAIM ANALYSIS

Application Number: 15898258
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-02
Patent Classification: ["514", "263400"]

Abstract:
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that modulate (e.g., agonizes or partially agonizes) NLRP3 that are useful, e.g., for treating a condition, disease or disorder in which an increase in NLRP3 signaling may correct a deficiency in innate immune activity (e.g., a condition, disease or disorder associated with an insufficient immune response) that contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Claim (Index 12):
The compound of  claim 11 , wherein:\n R 1  and R 2 , together with the nitrogen atom to which each is attached forms a saturated or unsaturated ring including from 5 to 6 ring atoms, wherein the ring includes: (a) from 3 to 5 ring carbon atoms, each of which is optionally substituted with from 1 to 2 independently selected R f , and (b) from 0 to 1 ring heteroatom (in addition to the nitrogen atom attached to R 1  and R 2 ), which is independently selected from: N, N(R e ), O, and S; and provided that one of the ring atoms is \u2014C(O)\u2014; R 3  is: H, unsubstituted C 1-2  alkyl, X\u2014R 8 , wherein X is an unbranched C 1-6  alkylene, and R 8  is CO 2 R a , or \u2014CONR c R d ; R 4  is independently H or halo; R 5  is independently selected from: (i) H; (ii) halo; (iii) C 3-8  cycloalkyl optionally substituted with from 1 to 2 independently selected R f ; (iv) phenyl optionally substituted with from 1 to 3 R g ; and (v) heteroaryl including from 5 to 9 ring atoms, wherein from 1 to 3 ring atoms are each independently selected from: N, N(R e ), O, and S, wherein the heteroaryl is optionally substituted with from 1 to 3 R g ; (vi) C 1-6  alkyl optionally substituted with from 1 to 2 independently selected R h ; and (vii) C 5-6  cycloalkenyl optionally substituted with from 1 to 2 R f .

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 1.95588
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16093990', '16094000', '12813148', '15016841', '14982131']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7816696315323401
- 35 USC 102 Novelty (BERT): 0.5116854506114581
- Combined Prediction Score: 0.7546712134402519
- Mean Citation Score: 263.79211200000003
- Max Citation Score: 286.65015
- Similarity Product: 210.1016375715405

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test