PATENT CLAIM ANALYSIS

Application Number: 16037678
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "254070"]

Abstract:
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.

Claim (Index 51):
A method of synthesizing compound 9 according to the chemical structure: Where n and n\u2032 are each independently an integer from 1 to 6, or a pharmaceutically acceptable salt thereof, comprising reacting compound 3 with compound 4 in the presence of tetrakis(triphenylphosphine)palladium (Pd(PPh 3 ) 4  in dimethylformamide/water to produce compound 5 according to the chemical structure: where Boc is a tertiarybuyloxycarbonyl group; removing the Boc protecting group with trifluoroacetic acid to produce compound 6 according to the chemical structure: reacting compound 6 with compound 2 to produce compound 7 which is reacted with alkyne compound 8 where DNP is a dinitrophenyl group, in the presence of copper sulfate (CuSO 4 ) and ascorbate to produce compound 9 or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.64935
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13988251', '15379969', '13501592', '14883959', '15890040']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.725050817418937
- 35 USC 102 Novelty (BERT): 0.5282306375209534
- Combined Prediction Score: 0.7053687994291387
- Mean Citation Score: 274.790116
- Max Citation Score: 310.8083
- Similarity Product: 198.13886107226608

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test