PATENT CLAIM ANALYSIS

Application Number: 15946066
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "466000"]

Abstract:
Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, The method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of PCSK9, and to stimulate secretion of glucagon-like peptide 1 in mammals.

Claim (Index 13):
A method to inhibit activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) in mammals, the method comprising administering to the mammal a PCSK9 inhibitory-effective amount of a compound selected from the group consisting of wherein each R 1  and R 1 \u2032 is independently hydrogen or alkyl; and each R, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 3 \u2032, R 4 \u2032, R 5 \u2032, R 6 \u2032, and R 7 \u2032 is independently selected from hydrogen, halogen, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heterocyclylallkyl; R 3 \u2032 may additionally be selected from acyl (\u2014C(\u2550O)H); or a pharmaceutically suitable salt thereof.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 91.0
- Lexical Diversity: 1.66129
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14818960', '14239541', '14111991', '14977011', '15541875']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7644603752673577
- 35 USC 102 Novelty (BERT): 0.5795193030975415
- Combined Prediction Score: 0.745966268050376
- Mean Citation Score: 344.059252
- Max Citation Score: 563.0151
- Similarity Product: 370.2196940876841

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test