PATENT CLAIM ANALYSIS

Application Number: 16209112
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-09
Patent Classification: ["514", "380000"]

Abstract:
In one aspect, the invention relates to compounds having the formula: where X, R a , R b , R 2 , and R 7  are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

Claim (Index 42):
A method of inhibiting activity of a neprilysin enzyme, comprising contacting the neprilysin enzyme with a compound of formula V: or a pharmaceutically acceptable salt thereof, wherein:\n R a  is selected from Cl and F and R b  is H; or R a  is H and R b  is selected from Cl, F, \u2014CH 3 , and \u2014CN; or R a  is F and R b  is Cl; \n R 2  is selected from H, \u2014C 1-6 alkyl, \u2014(CH 2 ) 2-3 OR e , and \u2014(CH 2 ) 2-3 NR e R e ; \n R 3  is selected from \u2014OH, \u2014OCH 3 , \u2014OCH 2 CH 3 , and \u2014C 1-4 alkyl; \n R 7  is selected from H, \u2014C 1-6 alkyl, \u2014[(CH 2 ) 2 O] 1-3 CH 3 , \u2014CHR c OC(O)\u2014C 1-4 alkyl, \u2014CH 2 OC(O)CHR d \u2014NH 2 , \u2014CH 2 OC(O)CHR d \u2014NHC(O)O\u2014C 1-6 alkyl, \u2014CHR c OC(O)O\u2014C 2-4 alkyl, \u2014CHR c OC(O)O-cyclohexyl, \u2014CH 2 CH(NH 2 )C(O)OCH 3 , \u2014C 2-4 alkylene-N(CH 3 ) 2 , \u2014C 0-6 alkylenemorpholinyl, and \n R c  is selected from H and \u2014C 1-3 alkyl; R d  is selected from H, \u2014CH 3 , \u2014CH(CH 3 ) 2 , phenyl, and benzyl; and each R e  is independently selected from H and \u2014CH 3 .

Metadata:
- Claim Count in Document: 59.0
- Percentile: 98.0
- Lexical Diversity: 1.67347
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13961269', '13911819', '13911552', '14812095', '14838842']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7838649148020198
- 35 USC 102 Novelty (BERT): 0.563713079182309
- Combined Prediction Score: 0.7618497312400487
- Mean Citation Score: 414.121838
- Max Citation Score: 497.09735
- Similarity Product: 299.1395679305285

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test