PATENT CLAIM ANALYSIS

Application Number: 16093990
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["514", "232800"]

Abstract:
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that modulate (e.g., agonizes or partially agonizes) NLRP3 that are useful, e.g., for treating a condition, disease or disorder in which a decrease in NLRP3 activity (e.g., a condition, disease or disorder associated with repressed or impaired NLRP3 signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Claim (Index 211):
A compound having formula (I), or a pharmaceutically acceptable salt thereof: wherein: R 1  is: (i) H; or (ii) X\u2014R 5 , wherein X is an unbranched C 1-6  alkylene, and R 5  is hydrogen; R 2  is: (i) Y\u2014R 6 , wherein:\n Y is C 2-8  alkylene, which is optionally substituted with from 1-4 R e ; and \n R 6  is \u2014OH, CO 2 R a ; \u2014CONR b R c , or heteroaryl including from 5-6 ring atoms, wherein from 1-4 ring atoms are each independently selected from the group consisting of nitrogen, oxygen and sulfur; \n R 3  is independently selected from the group consisting of: (i) C 1-4  alkyl; (ii) \u2014(C 1-3  alkylene) y -C 5-8  cycloalkyl, wherein the cycloalkyl is optionally substituted with from 1-4 independently selected R g , wherein y is 0 or 1; (iii) \u2014(C 1-3  alkylene) y -heterocyclyl including from 5-8 ring atoms, wherein from 1-3 ring atoms are each independently selected from the group consisting of N(R f ), O, and S, wherein the heterocyclyl is optionally substituted with from 1-4 substituents independently selected from oxo and R g , wherein y is 0 or 1; (iv) \u2014(C 1-3  alkylene) y -phenyl optionally substituted with from 1-4 R d , wherein y is 0 or 1; and (v) \u2014(C 1-3  alkylene) y -heteroaryl including from 5-10 ring atoms, wherein from 1-4 ring atoms are each independently selected from the group consisting of N, N(R f ), O, and S, wherein the heteroaryl is optionally substituted with from 1-3 R d , wherein y is 0 or 1; R 4  is independently selected from: hydrogen, halo, cyano, C 1-4  alkyl, C 1-4  haloalkyl, and C 1-4  alkoxy; R a  is: (i) H; or (ii) C 1-6  alkyl; each occurrence of R b  and R is independently R a ; each occurrence of R d  is independently selected from the group consisting of: (i) halo; (ii) cyano; (iii) C 1-6  alkyl optionally substituted with from 1-2 substituents independently selected from \u2014OH, C 1-4  alkoxy, C 1-4  haloalkoxy, \u2014CO 2 R a ; \u2014CONR b R c , cyano, and \u2014NR b R c ; (iv) C 2-6  alkenyl; (v) C 2-6  alkynyl; (vi) C 1-4  haloalkyl; (vii) C 1-4  alkoxy; (viii) C 1-4  haloalkoxy; (ix) \u2014NR b R c ; (x) \u2014OH; (xi) \u2014S(O) 1-2 (NR b R c ); and (xii) \u2014C 1-4  thioalkoxy; each occurrence of R e  is independently selected from the group consisting of: F, \u2014OH, C 1-4  alkoxy, C 1-4  haloalkoxy, CO 2 R a , \u2014CONR b R c , and \u2014NR b R c ; each occurrence of R f  is independently selected from the group consisting of: H, C 1-4  alkyl, \u2014C(O)(C 1-4  alkyl), \u2014C(O)O(C 1-4  alkyl), \u2014OH, and C 1-4  alkoxy; and each occurrence of R g  is independently selected from the group consisting of: C 1 -6 alkyl, C 1-4  haloalkyl, F, \u2014OH, C 1-4  alkoxy, C 1-4  haloalkoxy, and CO 2 R a .

Metadata:
- Claim Count in Document: 35.0
- Percentile: 97.0
- Lexical Diversity: 2.01613
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15898258', '16094000', '15620396', '12813148', '13035640']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8049036838818966
- 35 USC 102 Novelty (BERT): 0.5398212321705453
- Combined Prediction Score: 0.7783954387107614
- Mean Citation Score: 280.91243
- Max Citation Score: 390.9892
- Similarity Product: 289.01758373985285

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test