PATENT CLAIM ANALYSIS

Application Number: 15741995
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "501000"]

Abstract:
A process for preparing poly(lactide-co-glycolide) copolymer particles with an average particle size in the range of 50-800 nm includes transferring a mixture of poly(lactide-co-glycolide) copolymer, ethanol and carbon dioxide from a first reactor into a second reactor under rapid reduction of the pressure and expansion with phase separation into a gas phase, an ethanol aerosol and an ethanolic suspension containing poly(lactide-co-glycolide) copolymer particles, removing the carbon dioxide gas and the ethanol aerosol from the second reactor, and obtaining the poly(glycolide-co-lactide) copolymer particles in the form of an ethanolic suspension or in dry form from the second reactor.

Claim (Index 1):
A process for preparing poly(lactide-co-glycolide) copolymer particles with an average particle size in the range of 50-800 nm, the process comprising the steps:\n a) transferring ethanol and a poly(lactide-co-glycolide) copolymer with a content of polymerized monomer units of 55-80 mol % lactide and 20 to 45 mol % of glycolide and a molecular weight M w  of 1,000-25,000 into a first reactor with a stirring equipment, b) feeding carbon dioxide into the first reactor so that carbon dioxide is from 65 to 85% by weight and the ethanol is 15 to 35% by weight whereby carbon dioxide and ethanol add up to 100%, c) mixing the poly(lactide-co-glycolide) copolymer, the ethanol, and the carbon dioxide by stirring and adjusting or maintaining the mixture in the first reactor to a temperature of at least 31 and up to 70\u00b0 C. and a pressure of from 7.38 MPa to 50 MPa, where carbon dioxide enters the supercritical stage with ethanol as a co-solvent, d) stirring the mixture from step c) for 1 to 5 hours, whereby at least a part of the poly(glycolide-co-lactide) copolymer becomes dissolved in the mixture of carbon dioxide and ethanol, e) transferring the mixture from step d) into a second reactor under rapid reduction of the pressure and expansion with phase separation into a gas phase, an ethanol aerosol and an ethanolic suspension containing poly(lactide-co-glycolide) copolymer particles, f) removing the carbon dioxide gas and the ethanol aerosol from the second reactor, and g) obtaining the poly(glycolide-co-lactide) copolymer particles with an average particle size in the range of 50-800 nm in the form of an ethanolic suspension or in dry form from the second reactor.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 86.0
- Lexical Diversity: 2.11111
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15314343', '15524412', '09308435', '12739588', '13462395']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7207017582416851
- 35 USC 102 Novelty (BERT): 0.5075381912594312
- Combined Prediction Score: 0.6993854015434597
- Mean Citation Score: 221.172008
- Max Citation Score: 237.96347000000003
- Similarity Product: 144.48688649993062

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test