PATENT CLAIM ANALYSIS

Application Number: 15925670
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["554", "037000"]

Abstract:
What is described is a method of synthesis of the compound of formula 1A, or a salt thereof, wherein R 3  is a linear or branched alkene of 1, 2, 3, 4, 5 or 6 carbons; R 4  and R 5  are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; and L 3  is a bond or an alkane of 1, 2, 3, 4, 5 or 6 carbons.

Claim (Index 1):
A method of synthesis of the compound of formula 1A, or a salt thereof, comprising the steps reacting 8-bromooctanoic acid with methanol in the presence of H 2 SO 4  to produce methyl 8-bromooctanoate; reacting 8-bromooctanoate with benzyl amine to produce dimethyl 8,8\u2032-(benzanediyl)dioctanoate; hydrogenating dimethyl 8,8\u2032-(benzanediyl)dioctanoate to produce dimethyl 8,8\u2032-azanediyldioctanoate; protecting dimethyl 8,8\u2032-azanediyldioctanoate by reacting with di-t-butyl dicarbonate (BOC) anhydride to produce dimethyl 8,8\u2032-(BOC-azanediyl) dioctanoate; reacting dimethyl 8,8\u2032-(BOC-azanediyl) dioctanoate with sodium hydroxide to produce 8,8\u2032-(BOC-azanediyl) dioctanoic acid; reacting 8,8\u2032-(BOC-azanediyl) dioctanoic acid with 1-]bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate and di-isopropyl ethyl amine, and then with 4-dimethylaminopyridine and cis-2-nonene-1-ol to produce di((Z)-non-2-en-1-yl) 8,8\u2032(BOC-azanediyl) dioctanoate; and reacting di((Z)-non-2-en-1-yl) 8,8\u2032(BOC-azanediyl) dioctanoate with a compound of formula 1B, to produce the compound of formula 1A; wherein\n R 3  is a linear or branched alkene of 1, 2, 3, 4, 5 or 6 carbons; \n R 4  and R 5  are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; and \n L3 is a bond and X is H, or \n L3 is an alkane of 1, 2., 3, 4, 5 or 6 carbons and X is \u2014(CH 2 ) q \u2014COOH, wherein q is 1, 2, 3, 4, 5 or 6.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 90.0
- Lexical Diversity: 2.525
- Patent Class: 554.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14546105', '15423008', '15818424', '15899314', '15400691']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6752943654441979
- 35 USC 102 Novelty (BERT): 0.5355937806145301
- Combined Prediction Score: 0.6613243069612311
- Mean Citation Score: 352.778876
- Max Citation Score: 355.45257999999984
- Similarity Product: 180.3487704134607

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test