PATENT CLAIM ANALYSIS

Application Number: 16024283
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "649000"]

Abstract:
Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

Claim (Index 29):
An isolated compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10  are independently H, amino, C 1-6  alkyl, alkenyl, alkynyl, halo, hydroxyl, carbocyclic, heterocyclic, or aryl; R 11  is H, acyl, amino, amido, azido, carboxyl, alkyl, aryl, aralkyl, halo, guanidinyl, oxo, sulfanyl, sulfenyl, sulfonyl, heterocyclyl, heteroaryl, or hydroxyl; R 12 , R 13  are independently H, acyl, alkyl, alkyenyl, alkynyl, aralkyl, aryl, carboxyl, cycloalkyl, heterocyclic, or other amino (in the case of hydrazide) or R 12  and R 13  together with the nitrogen atom to which they are attached, form a ring having 4-8 atoms. X is (CH 2 ) n , where n=1-6; Y is-CN or \u2014C(O)R 14 ; R 14  is alkyl, alkanyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkoxy, aryloxy, aralkyl, or amino; and * is a stereocenter selected from R or S configuration, wherein either the stereocenter * is in an R configuration, and the compound is present in greater than 90%, 95%, 97%, 99%, 99.5%, or 99.9% enantiomeric excess (e.e) compared to the S isomer, or the stereocenter * is in an S configuration, and the compound is present in greater than 90%, 95%, 97%, 99%, 99.5%, or 99.9% enantiomeric excess (e.e) compared to the R isomer.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 94.0
- Lexical Diversity: 1.39474
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15245935', '14190702', '13759382', '12530214', '14465470']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7563451371723167
- 35 USC 102 Novelty (BERT): 0.6479814151663476
- Combined Prediction Score: 0.7455087649717198
- Mean Citation Score: 303.701184
- Max Citation Score: 774.36896
- Similarity Product: 554.8944734738922

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test