PATENT CLAIM ANALYSIS

Application Number: 15998791
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["546", "212000"]

Abstract:
The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.

Claim (Index 11):
A method for preparing a 2,3,5-substituted thiophene compound, the method comprising:\n (Step 1) preparing a compound of Formula 4, in which an acetylene group is introduced into a C5 position of thiophene by allowing 2-(Boc protected carboxamido)-3-amino-5-bromo-thiophene represented by Formula 2 to react with trimethylsilylacetylene represented of Formula 3, wherein, R 2  and n are the same as those defined in  claim 1 , TMS is a trimethylsilyl group, and Boc is a tert-butoxycarbonyl group; (Step 2) preparing a compound of Formula 5 by desorbing a trimethylsilyl (TMS) protecting group from a compound of Formula 4, wherein, R 2  and n are the same as those defined in  claim 1 , TMS is a trimethylsilyl group, and Boc is a tert-butoxycarbonyl group;\n (Step 3) preparing a compound of Formula 7 by allowing a compound of Formula 5 to react with a halide compound of Formula 6, \n wherein, R 1 , R 2 , A, and n are the same as those defined in  claim 1 , X is a halogen atom, TMS is a trimethylsilyl group, and Boc is a tert-butoxycarbonyl group; (Step 4) preparing a compound of Formula 9 by allowing a compound of Formula 7 to react with trichloroacetyl isocyanate of Formula 8, wherein, Z, R 1 , R 2 , A, and n are the same as those defined in  claim 1 , and Boc is a tert-butoxycarbonyl group; (Step 5) preparing a compound of Formula 10 by removing a trichloroacetyl (F 3 CC(O)\u2014) group from a compound of Formula 9, wherein, Z, R 1 , R 2 , A, and n are the same as those defined in  claim 1 , and Boc is a tert-butoxycarbonyl group; and (Step 6) preparing a compound of Formula 1a by desorbing a tert-butoxycarbonyl (Boc) group from a compound of Formula 10, wherein, Z, R 1 , R 2 , A, and n are the same as those defined in  claim 1 , and Boc is a tert-butoxycarbonyl group.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.2069
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15370631', '14153891', '13834316', '13980182', '13080762']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.777298152242159
- 35 USC 102 Novelty (BERT): 0.5015911979993597
- Combined Prediction Score: 0.7497274568178791
- Mean Citation Score: 258.022286
- Max Citation Score: 262.91245
- Similarity Product: 182.9790521541804

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test