PATENT CLAIM ANALYSIS

Application Number: 15979128
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "236200"]

Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).

Claim (Index 11):
The compound of  claim 1 , which is selected from compounds of Formula (VIa-1), (VIa-2), (VIa-3), or (VIa-4), or a pharmaceutically acceptable salt thereof: wherein R 1  and R 2  are delineated for each compound in Table 5, TABLE 5 Entry R 1 R 2 401 Me   402 Me   403 Me   404 Me   405 Me   406 Me   407 Me   408 Me   409 Me   410 Me   411 CF 3   412 CF 3   413 CF 3   414 CF 3   415 CF 3   416 CF 3   417 CF 3   418 CF 3   419 CF 3   420   421   422   423   424   425   426   427   428   429   430   430   432   433   434   435   436   437   438   439   440   441   442   443   444   445   446   447   448   449   450   451   452   453   454   455   456   457   458   459   460   461   462   463   464   465   466   467   468   469   470   471   472   473   474   475   476   477   478   479   480   481   482   483   484   485   486   487   488   489   490   491   492   493   494   495   496   497   498   499   500

Metadata:
- Claim Count in Document: 44.0
- Percentile: 93.0
- Lexical Diversity: 1.84416
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12974622', '15724919', '16063542', '14670421', '15597417']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.785589647815195
- 35 USC 102 Novelty (BERT): 0.5211861616721665
- Combined Prediction Score: 0.7591492992008922
- Mean Citation Score: 304.51726799999994
- Max Citation Score: 310.5816700000001
- Similarity Product: 221.5595982051612

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test