PATENT CLAIM ANALYSIS

Application Number: 15763007
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["424", "423000"]

Abstract:
A composite material for bone repair based on a decellularized biological tissue matrix material and a preparation method thereof. The composite material for bone repair comprises an organic phase of a microfibrillar decellularized animal tissue matrix material and an inorganic phase of a calcium salt bioceramic or other inorganic bioglass. A preparation process for the composite material for bone repair does not need physical or chemical crosslinking. The composite material for bone repair has a three-dimensional porous network structure, and protein components in the biological tissue matrix material maintain a natural triplex structure. The composite material for bone repair has excellent biocompatibility, biodegradability, osteoconductivity, osteoinductivity, and osteogenecity, also has certain mechanical strength and shape memory function, and can be used as a bone filling material or a repair material for large-area bone defect.

Claim (Index 9):
A preparation method of the composite material for bone repair according to  claim 1 , characterized in that it comprises the following steps:\n 9.1) preparing a microfibrillar decellularized biological tissue matrix material according to the step 8.1) defined in  claim 8 ; 9.2) preparing the composite material for bone repair, comprising the following steps:\n (a) transferring the decellularized biological tissue matrix material in step 9.1) into a mold, placing the mold filled with the material at a temperature of \u221220\u00b0 C. to \u2212196\u00b0 C. for 1-24 hours to obtain a frozen biological tissue matrix material; \n (b) removing the solvent from the biological tissue matrix material at a frozen state obtained in (a) of step 9.2) at a low temperature of \u221220\u00b0 C. to 10\u00b0 C. and under a vacuum environment of 10-2000 millitorr for 12-96 hours, obtaining a three-dimensional porous biological tissue matrix material; \n (c) soaking the three-dimensional porous biological tissue matrix material obtained in (b) of step 9.2) in a solution containing calcium ion at 20-37\u00b0 C. for 1-4 hours, then taking out the biological tissue matrix material, and washing with deionized water three times, each time for 5 minutes; soaking the biological tissue matrix material in a solution containing phosphate ion at 20-37\u00b0 C. for 1-4 hours, then taking out the biological tissue matrix material, and washing with deionized water three times, each time for 5 minutes; the molar ratio of the addition amount of the calcium ion to that of the phosphate ion is Ca/P=1/1 to 2/1; repeating the above steps 5 times to obtain a three-dimensional porous composite material for bone repair; \n (d) terminally sterilizing the composite material for bone repair obtained in (c) of step 9.2).

Metadata:
- Claim Count in Document: 13.0
- Percentile: 90.0
- Lexical Diversity: 1.9863
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['09284297', '10534794', '12188127', '09993739', '14728336']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7343993973663266
- 35 USC 102 Novelty (BERT): 0.5101303652454701
- Combined Prediction Score: 0.711972494154241
- Mean Citation Score: 257.50511800000004
- Max Citation Score: 277.0647
- Similarity Product: 184.58289277864696

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test