PATENT CLAIM ANALYSIS

Application Number: 15953091
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "009100"]

Abstract:
Modified FGF-21 polypeptides and uses thereof are provided.

Claim (Index 112):
A composition comprising a pharmaceutically acceptable carrier and a modified FGF-21 polypeptide comprising a non-naturally encoded amino acid, wherein:\n (a) the modified FGF-21 polypeptide comprises a sequence at least 90% identical to SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO: 7; (b) the non-naturally encoded amino acid has the structure: wherein the R group is any substituent other than the side chain found in alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, pyrrolysine, or selenocysteine; (c) the modified FGF-21 polypeptide contains a substitution of an amino acid with the non-naturally encoded amino acid at position 108 of SEQ ID NO: 1 or the corresponding amino acid position in SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO: 7; (d) the modified FGF-21 polypeptide maintains the biological activity of human FGF-21 polypeptides; (e) the non-naturally encoded amino acid is linked to a linker, polymer, or biologically active molecule; and (f) the modified FGF-21 polypeptide has an in vivo half-life at least two-fold greater than the human FGF-21 polypeptide of SEQ ID NO: 1.

Metadata:
- Claim Count in Document: 79.0
- Percentile: 91.0
- Lexical Diversity: 1.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14680543', '15292700', '13212101', '15239277', '15386347']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7621586715054176
- 35 USC 102 Novelty (BERT): 0.6418065579560008
- Combined Prediction Score: 0.7501234601504759
- Mean Citation Score: 527.7908259999998
- Max Citation Score: 653.8277
- Similarity Product: 549.7465837545099

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test