PATENT CLAIM ANALYSIS

Application Number: 15914958
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["514", "094000"]

Abstract:
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

Claim (Index 1):
A compound of Formula (I): or a tautomer thereof, or a prodrug of each thereof, or a deuterium isotope of each of the above wherein up to 10, preferably up to 6, more preferably up to 3 hydrogen atoms that are attached to one or more carbon atoms are replaced with deuterium(s), or a pharmaceutically acceptable salt of each of the foregoing, or a pharmaceutically acceptable solvate of each of the above mentioned, wherein A is an optionally substituted 5-membered heterocyclyl containing a \u2014C(O)NZC(O)-moiety, a \u2014C(O)OC(O) moiety, a \u2014C(O)CR 10 C(O) moiety, or a \u2014C(O)NR 10 C(O) moiety; or A is a 5-membered heteroaryl or a 5-membered substantially planar heterocyclyl (i.e., a heterocyclyl wherein at least 3 or at least 4 atoms can stably be in a same plane) substituted at 1,3 positions with substituents selected from halo, optionally substituted hydroxy, and optionally substituted \u2014SH groups, preferably two fluoros, wherein the 5-membered heteroaryl or substantially planar heterocyclyl is further optionally substituted; or A is preferably: each R 10  independently is hydrogen, an optionally substituted C 1 -C 10  alkoxy, or an optionally substituted C 1 -C 10  alkyl, preferably R 10  is hydrogen; each R 30  independently is hydrogen; an optionally substituted C 1 -C 10  alkoxy; optionally substituted amino, such as \u2014NH 2  or a mono or di-substituted form thereof; an optionally substituted C 1 -C 10  alkyl; optionally substituted hydroxy; a prodrug moiety, or Z; or R 30  and L 1  together with the atoms they are attached to form a 5-7 membered ring; L 1  is a linker having 2-8 chain atoms selected from C, N, O, S, and/or P, wherein the linker is optionally substituted; L 2  is \u2014SO 2 NR 50 \u2014, wherein the sulfur is attached to L 1 ; \u2014NR 50 SO 2 \u2014, wherein the nitrogen is attached to L 1 ; \u2014C(O)NR 50 \u2014, wherein the carbon is attached to L 1 ; \u2014NR 50 C(O)\u2014, wherein the nitrogen is attached to L 1 ; \u2014NR 50 SO 2 NR 50 \u2014; or \u2014NR 50 CONR 50 \u2014; each R 50  independently is hydrogen, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 2 -C 6  heteroalkyl, an optionally substituted C 2 -C 6  alkenyl, an optionally substituted C 3 -C 6  heteroalkenyl, an optionally substituted C 2 -C 6  alkynyl, an optionally substituted C 3 -C 6  heteroalkynyl, or Z; Z is each R 51  and R 52  independently is hydrogen or an optionally substituted C 1 -C 10  alkyl; X is an optionally substituted hydroxy group, an optionally substituted NH 2  group, or an optionally substituted SH group; L 3  is a bond or a linker, preferably a linker, having 2-8 chain atoms selected from C, N, O, S, and/or P, wherein the linker is optionally substituted, preferably L 3  is an optionally substituted C 1 -C 6  alkylene, an optionally substituted C 2 -C 6  heteroalkylene, an optionally substituted C 2 -C 6  alkenylene, an optionally substituted C 3 -C 6  heteroalkenylene, an optionally substituted C 2 -C 6  alkynylene, or an optionally substituted C 3 -C 6  heteroalkynylene; and B is an optionally substituted 6-10 membered aryl; an optionally substituted 5-15 membered heteroaryl; an optionally substituted 4-15 membered heterocyclyl; or an optionally substituted 3-15 membered cycloalkyl, if cycloalkyl, then preferably at least a 4 membered, or more preferably a 5-10 membered cycloalkyl; provided that A is not

Metadata:
- Claim Count in Document: 17.0
- Percentile: 90.0
- Lexical Diversity: 1.26667
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15741202', '15740783', '15740787', '15741205', '15109616']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8301843813278973
- 35 USC 102 Novelty (BERT): 0.584355986486488
- Combined Prediction Score: 0.8056015418437563
- Mean Citation Score: 447.784362
- Max Citation Score: 508.83127
- Similarity Product: 421.0250529850292

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test