PATENT CLAIM ANALYSIS

Application Number: 15956133
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-04
Patent Classification: ["514", "017700"]

Abstract:
Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and/or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

Claim (Index 53):
The method of  claim 1 , wherein the necrosis inhibitor is a compound of Formula IV: or a pharmaceutically acceptable salt, an ester, or a prodrug thereof, wherein:\n R 1  is \n R 2  and R 3  each represent independently for each occurrence hydrogen or methyl; R 4  represents independently for each occurrence halogen, hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 4 alkynyl; R 5  is C 1 -C 4 alkyl; R 6  is hydrogen, halogen, or \u2014CN; R 7  is hydrogen or C 1 -C 4 alkyl; R 8  is C 1 -C 6 alkyl, or R 8  taken together with R 9 , when present, forms a carbocyclic ring; R 9  is hydrogen or C 1 -C 6 alkyl, or R 9  taken together with R 8  forms a carbocyclic ring; R 10  is hydrogen or C 1 -C 6 alkyl; A is phenylene or a 5-6 membered heteroarylene; X is N or \u2014C(R 9 )\u2014; Y is N or \u2014C(R 10 )\u2014; Z is S or O; and m and n each represent independently 1, 2, or 3.

Metadata:
- Claim Count in Document: 73.0
- Percentile: 91.0
- Lexical Diversity: 1.66102
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15093480', '15288214', '14934810', '12086792', '15100967']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7804512802128687
- 35 USC 102 Novelty (BERT): 0.738267316186344
- Combined Prediction Score: 0.7762328838102163
- Mean Citation Score: 535.4984059999998
- Max Citation Score: 823.15753
- Similarity Product: 800.3368275955528

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test