PATENT CLAIM ANALYSIS

Application Number: 16034876
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["548", "953000"]

Abstract:
The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be prepared by an acid-catalyzed reaction of a suitably selected and substituted di-halo-olivetol or derivative thereof with a suitably selected and substituted cyclic alkene to produce a dihalo-cannabidiol compound or derivative thereof. The dihalo-cannabidiol compound or derivative thereof can be produced in high yield, high stereospecificity, or both. It can then be converted under reducing conditions to a cannabidiol compound or derivatives thereof.

Claim (Index 12):
A process for the preparation of a compound of formula (VI) wherein a is an integer from 0 to 3; R 1  and R 2  are each independently selected from the group consisting of H, OH, protected hydroxyl, alkyl, alkenyl, alkynyl, acyl, aryl, heteroaryl, cycloalkyl or heterocycle; wherein the alkyl, alkenyl, alkynyl or acyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, \u2014OH, alkyl, \u2014O-alkyl, NR A R B , \u2014S-alkyl, \u2014SO-alkyl, \u2014SO 2 -alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycle; wherein R A  and R B  are each independently selected from hydrogen and C 1-4  alkyl; wherein the aryl or heteroaryl, whether alone or as part of a sub stituent group, is optionally substituted with one or more substituents independently selected from the group consisting of halogen, \u2014OH, alkyl, \u2014O-alkyl, \u2014COOH, \u2014C(O)\u2014C 1-4  alkyl, \u2014C(O)O\u2014C 1-4  alkyl, NR C R D , \u2014S-alkyl, \u2014SO-alkyl and \u2014SO 2 -alkyl; wherein R C  and R D  are each independently selected from hydrogen and C 1-4  alkyl; R 3  is selected from the group consisting of H, alkyl, acyl, \u2014SO 2 -alkyl, \u2014SO 2 -aryl and \u2014SO 2 -heteroaryl; wherein the alkyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, \u2014OH, alkyl, \u2014O-alkyl, NR E R F , \u2014S-alkyl, \u2014SO-alkyl, \u2014SO 2 -alkyl, aryl and heteroaryl; and wherein R E  and R F  are each independently selected from hydrogen and C 1-4  alkyl; wherein the aryl or heteroaryl, whether alone or as part of a substituent group, is optionally substituted with one or more substituents independently selected from the group consisting of halogen, \u2014OH, alkyl, \u2014O-alkyl, NR G R H , \u2014S-alkyl, \u2014SO-alkyl and \u2014SO 2 -alkyl; wherein R G  and R H  are each independently selected from hydrogen and C 1-4  alkyl; each   represents a single or double bond; provided that both   groups are not double bonds, and wherein denoted, dash marks indicate the points of attachment; or a pharmaceutically acceptable salt or ester thereof; the process comprises reacting a compound of formula (II), wherein each X is independently selected from the group consisting of Br, F and Cl, with a compound of formula (III) wherein R 0  is H or OH, in the presence of a protic or first Lewis acid catalyst to form a compound of formula (IV); reacting the compound of formula (IV) with a reducing agent to form the compound of formula (VI); and

Metadata:
- Claim Count in Document: 20.0
- Percentile: 95.0
- Lexical Diversity: 1.97826
- Patent Class: 548.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15199528', '11529147', '13108651', '14138893', '12397212']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7418319364875897
- 35 USC 102 Novelty (BERT): 0.6025862660947419
- Combined Prediction Score: 0.727907369448305
- Mean Citation Score: 339.3039320000001
- Max Citation Score: 520.15515
- Similarity Product: 481.2670075402379

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test