PATENT CLAIM ANALYSIS

Application Number: 15755558
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "468000"]

Abstract:
A derivative of  inula lineariifolia  lactone A, and in particular, a dimethylamine 4-O-acetyl  inula lineariifolia  lactone A or a salt thereof, preparation of same, and an application of same in preparation of medicine for treating multiple sclerosis. The dimethylamine 4-O-acetyl  inula lineariifolia  lactone A compound is represented by formula I:

Claim (Index 7):
The preparation method of the dimethylamine 4-O-acetyl  inula lineariifolia  lactone A compound and its pharmaceutically acceptable salt of  claim 6 , wherein:\n a ratio of the  inula lineariifolia  lactone A:the base:acetic anhydride (Ac 2 O) are 1.0eq:1.0-2.0eq:1.0-2.0eq in the step (I) of preparation of the compound I; the organic reagent is a reagent insoluble in water comprising one of ethyl acetate, dichloromethane, chloroform, tetrachloromethane, ethyl ether, petroleum ether, n-butyl alcohol, benzene, methylbenzene and tetrahydrofuran, or a mixture thereof, and preferably is dichloromethane; the base is a low molecular weight trialkyl-substituted amine comprising trimethylamine, triethylamine, tripropylamine or tributylamine, pyridine or substituted pyridine, and preferably is dimethylpyridine; a ratio of the 4-O-acetyl  inula lineariifolia  lactone A:dimethylamine hydrochloride:the base is 1.0eq:1.0-2.0eq:1.0-2.0eq in the step (4); the organic solvent is a low molecular weight fatty alcohol comprising one of methanol, ethanol, propanol, isopropanol, dichloromethane, chloroform, tetrachloromethane, ethyl ether, petroleum ether and ethyl acetate, or a mixture thereof, and preferably is ethanol; the organic reagent is a reagent insoluble in water comprising one of ethyl acetate, dichloromethane, chloroform, tetrachloromethane, ethyl ether, petroleum ether, n-butyl alcohol, benzene, methylbenzene and tetrahydrofuran, or a mixture thereof, and preferably is dichloromethane; the base is a low molecular weight trialkyl-substituted amine, pyridine or substituted pyridine, the alkyl group is methyl, ethyl, propyl or butyl, and preferably is triethylamine.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 88.0
- Lexical Diversity: 1.64706
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15504018', '11404267', '13119692', '15101582', '10530776']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7143916435016453
- 35 USC 102 Novelty (BERT): 0.506058808023429
- Combined Prediction Score: 0.6935583599538236
- Mean Citation Score: 227.362856
- Max Citation Score: 233.85928
- Similarity Product: 160.81750750366209

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test