PATENT CLAIM ANALYSIS

Application Number: 16389376
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["424", "139100"]

Abstract:
The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.

Claim (Index 1):
A method of treating or preventing a lung disease or condition in a human or animal subject, the method comprising selective targeting of pathogenic host cells, wherein the host cells are  E. coli, Actinobacillis, Diplococcus, Staphylococcus, Streptococcus, Mycobacterium, Chlamydia, Klebsiella, Legionella, Haemophilus  or  Pseudomonas  cells, wherein the host cells are comprised by a microbiota in the subject, wherein the method comprising:\n a. contacting the microbiota with an engineered nucleic acid sequence for producing a host modifying (HM) crRNA, and b. producing the HM-crRNA in a host cell, wherein the HM-crRNA is operable with a Cas nuclease in the host cell to form a HM-CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas system, and wherein the HM-crRNA comprises a sequence that is capable of hybridizing to a target sequence of the host cell to guide the Cas nuclease to the target sequence in the host cell, whereby the target sequence is modified by the HM-CRISPR/Cas system and the host cell is killed or growth of the host cell is reduced, thereby reducing the proportion of host cells in the microbiota; and wherein the microbiota is a lung microbiota.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 100.0
- Lexical Diversity: 1.67857
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16028311', '16192752', '16041595', '15820296', '15160405']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7554257595736765
- 35 USC 102 Novelty (BERT): 0.6019750185780598
- Combined Prediction Score: 0.7400806854741149
- Mean Citation Score: 408.900236
- Max Citation Score: 469.58035
- Similarity Product: 350.7923534680069

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test