PATENT CLAIM ANALYSIS

Application Number: 16126370
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2018-12
Patent Classification: ["424", "204100"]

Abstract:
The present invention relates to variants of herpes simplex virus (HSV) that selectively infect and replicate in cancer cells, including HSV strains that selectively infect and replicate in bladder cancer cells. Preferred HSV of the invention have intact endogenous Us11 and Us12 genes and have genes encoding ICP34.5 replaced with a gene encoding Us11 fused to an HSV immediate early (IE) promoter. The variant HSV of the invention also comprise one or more additional heterologous genes encoding immunomodulatory polypeptides. Methods and compositions using these variant HSV, e.g. for example, for treating cancer in a subject, are also provided.

Claim (Index 19):
A variant herpes simplex virus (HSV) having an intact endogenous Us12 encoding gene and an intact endogenous Us11 encoding gene, lacking functional ICP34.5 encoding genes, wherein each ICP34.5 encoding gene is replaced with a polynucleotide cassette comprising a nucleic acid sequence set forth in one of SEQ ID NO: 21, SEQ ID NO: 22, SEQ ID NO: 23, SEQ ID NO: 24 and SEQ ID NO: 25.

Metadata:
- Claim Count in Document: 119.0
- Percentile: 97.0
- Lexical Diversity: 1.65672
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14343108', '15489514', '16068823', '16068816', '16068826']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7819492050655831
- 35 USC 102 Novelty (BERT): 0.698901333433484
- Combined Prediction Score: 0.7736444179023731
- Mean Citation Score: 616.6056699999998
- Max Citation Score: 862.1135
- Similarity Product: 696.0245934207438

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test