PATENT CLAIM ANALYSIS

Application Number: 15997267
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["564", "457000"]

Abstract:
The present invention is directed to processes for the preparation of esketamine. The present invention is further directed to processes for the resolution of S-ketamine from a racemic or enantiomerically enriched mixture of ketamine. The present invention is further directed to an (S)-CSA salt of S-ketamine, more particularly a monohydrate form of the (S)-CSA salt of S-ketamine; and to an (R)-CSA salt of R-ketamine.

Claim (Index 6):
A process for the preparation of a monohydrate form of (S)-camphorsulfonic acid salt of S-ketamine comprising reacting ketamine with (S)-camphorsulfonic acid, wherein the (S)-camphorsulfonic acid is present in an amount in the range of from about 0.5 to about 2.0 molar equivalents (relative to the molar amount of ketamine); in the presence of water, wherein the water is present in an amount in the range of from about 3.5% to about 15%; in an organic solvent; at a temperature in the range of from about 20\u00b0 C. to about solvent reflux temperature; to yield the corresponding monohydrate form of (S)-camphorsulfonic acid salt of S-ketamine; wherein the monohydrate form of (S)-camphorsulfonic acid salt of S-ketamine is present in an enantiomeric excess in the range of from about 50% to about 100%.

Metadata:
- Claim Count in Document: 37.0
- Percentile: 94.0
- Lexical Diversity: 2.0
- Patent Class: 564.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15182698', '12417671', '14689712', '13630309', '14261713']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6564401598425049
- 35 USC 102 Novelty (BERT): 0.5275880105920374
- Combined Prediction Score: 0.6435549449174581
- Mean Citation Score: 221.77484600000005
- Max Citation Score: 268.33234
- Similarity Product: 208.15207435246467

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test