PATENT CLAIM ANALYSIS

Application Number: 15880513
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["800", "018000"]

Abstract:
The present invention provides a transgenic mouse which comprises a deficiency for murine T lymphocytes, B lymphocytes and NK cells, a deficiency for murine MHC class I and MHC class II molecules, and a functional xenogenic SIRPα transgene. This mouse is useful for in vivo screening of various compounds, including immuno-therapeutic agents and vaccines. The said mouse is also useful for testing the in vivo metabolism of xenobiotic compounds.

Claim (Index 27):
A method for screening the in vivo metabolism of xenobiotic compounds in the multichimeric mouse of  claim 21 , wherein said multichimeric mouse comprises settled human hepatocytes, said method comprising the steps of:\n administering the xenobiotic compound to be tested to the said multichimeric mouse in conditions allowing the said compound to interact with the settled human hepatocytes, and observing the biotransformation of the said compound by the said settled hepatocytes.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 86.0
- Lexical Diversity: 1.58333
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14388108', '15223879', '13847636', '12918676', '13551137']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6195862393376801
- 35 USC 102 Novelty (BERT): 0.6206686852048376
- Combined Prediction Score: 0.6196944839243959
- Mean Citation Score: 386.186864
- Max Citation Score: 670.8642
- Similarity Product: 524.3223061108947

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test