PATENT CLAIM ANALYSIS

Application Number: 15755893
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "418000"]

Abstract:
The invention relates to antibacterial compounds of formula I wherein X represents sulphur or CH═CH; R 1  represents H, PO 3 H 2 , SO 3 H, phosphonooxymethyl or the group —CO—R 2  wherein R 2  is as defined in the claims M is one of the groups M A  and M B  represented below   wherein A represents a bond or C≡C and R 1A , R 2A , R 3A  and R 1B  are as defined in the claims; and to salts thereof.

Claim (Index 20):
A compound according to  claim 1 , which is selected from the group consisting of:\n (2R)-4-(2-(((1S,2S)-2-((2R)-1,2-dihydroxyethyl)cyclopropyl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(2-((1-(2-fluoroethyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (R)\u2014N-hydroxy-4-(2-((1-isopropylazetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(2-((1-(2-hydroxy-2-methylpropyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(2-((4-(1-(oxetan-3-yl)azetidin-3-yl)phenyl)ethynyl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(6-oxo-2-((1-(tetrahydro-2H-pyran-4-yl)azetidin-3-yl)buta-1,3-diyn-1-yl)-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(2-((1-(oxetan-3-ylmethyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(2-((4-(1-(oxetan-3-yl)azetidin-3-yl)phenyl)ethynyl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)butanamide; (2R)-4-(2-(((1S,2S)-2-((3-fluoroazetidin-1-yl)methyl)cyclopropyl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(2-((1-((1s,3s)-3-hydroxycyclobutyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(2-((1-((1r,3r)-3-hydroxycyclobutyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(5-((4-(2-hydroxyethyl)phenyl)ethynyl)-1-oxoisoindolin-2-yl)-2-methyl-2-(methylsulfonyl)butanamide; 3-hydroxypropyl (2R)-3-((5-(4-(hydroxyamino)-3-methyl-3-(methylsulfonyl)-4-oxobutyl)-6-oxo-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)buta-1,3-diyn-1-yl)azetidine-1-carboxylate; (2R)\u2014N-hydroxy-4-(2-(((2R,3R)-2-(hydroxymethyl)-1-methylazetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(2-(((3R,5R)-5-(hydroxymethyl)-1-methylpyrrolidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(6-oxo-2-((1-((3R)-tetrahydrofuran-3-yl)azetidin-3-yl)buta-1,3-diyn-1-yl)-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(6-oxo-2-((1-((3S)-tetrahydrofuran-3-yl)azetidin-3-yl)buta-1,3-diyn-1-yl)-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)butanamide; (2R)\u2014N-hydroxy-4-(2-((1-((3-hydroxyoxetan-3-yl)methyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(2-(((2R,4R)-4-(hydroxymethyl)-1-methylazetidin-2-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(2-(((2S,3S)-2-(fluoromethyl)-1-methylazetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; and (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(6-oxo-2-(phenylethynyl)-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)butanamide;\n or a salt of such compound.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.71154
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15756366', '15123184', '15021649', '15311758', '15106790']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8448845740569532
- 35 USC 102 Novelty (BERT): 0.6004491636865655
- Combined Prediction Score: 0.8204410330199143
- Mean Citation Score: 514.21681
- Max Citation Score: 555.8367
- Similarity Product: 444.89839742041823

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test