PATENT CLAIM ANALYSIS

Application Number: 15968524
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-08
Patent Classification: ["514", "230500"]

Abstract:
The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels and/or accumulations of alpha-synuclein as well as cancer by administering a compound hat modulates HAT to a subject.

Claim (Index 1):
A method for treating cancer, the method comprising administering to a subject in need thereof, a therapeutic amount of a compound of Formula (I) or a pharmaceutical composition comprising a compound of Formula (I): wherein, Ar is R a  is H, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, O\u2014(C 1 -C 6 -alkyl), O\u2014(C 1 -C 6 -haloalkyl), halogen, CN, or NO 2 ; R b  is H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 3 -C 8 -cycloalkyl, C 2 -C 6 -heteroalkyl, C 3 -C 8 -heterocycloalkyl, aryl, heteroaryl, O\u2014(C 1 -C 6 -alkyl), O\u2014(C 3 -C 8 -cycloalkyl), O\u2014(C 2 -C 6 -alkenyl), O\u2014(C 3 -C 8 -heterocycloalkyl), N(R 10 )\u2014(C 1 -C 6 -alkyl), N(R 10 )\u2014(C 3 -C 8 -cycloalkyl), S\u2014(C 1 -C 6 -alkyl), O\u2014(C 2 -C 6 -alkyl)-N(R 10 ) 2 , O\u2014(C 3 -C 8 -cycloalkyl)-N(R 10 ) 2 , N(R 10 )\u2014(C 2 -C 6 -alkyl)-N(R 10 ) 2 , \u2014(C 1 -C 6 -alkyl)-N(R 10 ) 2 , \u2014(C 1 -C 6 -alkyl)-R 3 , O\u2014(C 1 -C 6 -alkyl)-R 3 , O\u2014(C 3 -C 8 -cycloalkyl)-R 3 , N(R 10 )\u2014(C 1 -C 6 -alkyl)-R 3 , O-aryl, or O-heteroaryl; R c  is H, \u2014(C 1 -C 6 -alkyl), O\u2014(C 1 -C 6 -alkyl), C(\u2550O)NH-phenyl, wherein phenyl is substituted with one or more halo or haloalkyl; R d  is H, OH, \u2014(C 1 -C 6 -alkyl), O\u2014(C 3 -C 8 -cycloalkyl), O\u2014(C 3 -C 8 -heterocycloalkyl), O\u2014(C 2 -C 6 -alkenyl), O\u2014(C 1 -C 6 -alkyl), O\u2014(C 2 -C 6 -alkyl)-N(R 10 ) 2 , \u2014(C 1 -C 6 -alkyl)-R 3 , O\u2014(C 1 -C 6 -alkyl)-R 3 , N(R 10 )\u2014(C 1 -C 6 -alkyl)-R 3 , \u2014N(R 10 )\u2014(C 1 -C 6 -alkyl), \u2014N(R 10 )\u2014(C 2 -C 6 -alkenyl), \u2014N(R 10 )\u2014(C 3 -C 8 -cycloalkyl), \u2014N(R 10 )\u2014(C 3 -C 8 -heterocycloalkyl), N(R 10 )\u2014(C 2 -C 6 -alkyl)-N(R 10 ) 2 , \u2014(C 1 -C 6 -alkyl)-N(R 10 ) 2 , S\u2014(C 2 -C 6 -alkyl)-N(R 10 ) 2 , OCH 2 C(O)O-alkyl, O-aryl, N-aryl, O-heteroaryl, or N-heteroaryl; W and Z are independently N or CR 1 ; X is \u2014CO\u2014, \u2014CON(R 10 )\u2014, \u2014CON(R 10 )(CH 2 ) n , \u2014(CH 2 )CON(R 10 )\u2014, \u2014(CH 2 ) n CON(R 10 )(CH 2 ) n \u2014, \u2014SON(R 10 )\u2014, \u2014SON(R 10 )(CH 2 ) n \u2014, \u2014SO 2 N(R 10 )\u2014, \u2014SO 2 N(R 10 )(CH 2 ) n \u2014, \u2014N(R 10 )C(\u2550O)N(R 10 )\u2014, \u2014N(R 10 )CO\u2014, \u2014N(R 10 )CO(CH 2 ) n \u2014, or \u2014N(R 10 )CO(CH 2 ) n \u2014, \u2014(CH 2 )N(R 10 )\u2014, \u2014C\u2550N\u2014; or Ar and X together form Y is N or CR 2 ; R 1  is H, halogen, O\u2014(C 1 -C 6 -alkyl), O\u2014(C 2 -C 6 -alkyl)N(R 10 ) 2 ; R 2  is H, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, O\u2014(C 1 -C 6 -alkyl), O\u2014(C 1 -C 6 -haloalkyl), halogen, CN, or NO 2 ; R 3  is cycloalkylamino, optionally containing a heteroatom selected from N(R 10 ), O and S; R 10  is independently H, \u2014(C 1 -C 4 -alkyl), \u2014(C 1 -C 4 -haloalkyl), \u2014(C 3 -C 8 -cycloalkyl), \u2014(C 3 -C 8 -heterocycloalkyl), aryl or heteroaryl; and n is an integer from 1-3, or a pharmaceutically acceptable salt thereof; with the proviso that Ar is not or\n when \n Ar is not wherein\n W and Z are each CH, R b  is ethoxy, R c  is hydrogen, and R d  is \u2014OCH 2 CH 2 N(CH 3 ) 2  or OH; or \n W is C\u2014OCH 2 CH 2 N(CH 3 ) 2 , Z is CH, R b  is hydrogen, R c  is hydrogen, and R d  is hydrogen; or \n W and Z are each CH, R b  is cyclopentyloxy, R c  is hydrogen, and R d  is \u2014OCH 2 CH 2 N(CH 3 ) 2 ; or \n W and Z are each CH, R b  is \u2014OCH 2 CH 2 N(CH 3 ) 2 , R c  is \u2014C(O)NH-(3-CF 3 , 4-Cl-phenyl), and R d  is \u2014OCH 2 CH 2 N(CH 3 ) 2 ; or \n W is CH, Z is C-ethoxy, R b  is ethoxy, R c  is \u2014C(O)NH-(3-CF 3 , 4-Cl-phenyl), and R d  is hydrogen; or \n W and Z are each CH, R b  is \u2014CH 2 CH 2 CH 2 (CH 3 ) 2 , R c  is \u2014C(O)NH-(3-CF 3 , 4-Cl-phenyl), and R d  is \u2014CH 2 CH 2 CH 2 N(CH 3 ) 2  or hydrogen; or \n W and Z are each CH, R b  is ethoxy, R c  is \u2014C(O)NH-(3-CF 3 , 4-Cl-phenyl), and R d  is hydrogen or \u2014OCH 2 CH 2 N(CH 3 ) 2 ; or \n W and Z are nitrogen, R b  is ethoxy, R c  is hydrogen, and R d  is-OCH 2 CH 2 N(CH 3 ) 2 ; or \n when \n Ar is not wherein R b  is ethoxy, or Ar is not wherein\n W and Z are each CH, R b  is \u2014Sethyl, R c  is hydrogen, and R d  is n-pentyl; or \n when \n Ar is not wherein\n W is CH, Z is nitrogen, R b  is \u2014SCH 3 , R c  is hydrogen, and R d  is n-pentyl; or \n when \n Ar is not wherein\n W and Z are each CH, R b  is hydrogen, R c  is hydrogen, and R d  is \u2014OCH 2 CH 2 N(CH 3 ) 2 ; or \n when \n Ar is not wherein\n W and Z are each CH, R b  is ethoxy, R c  is hydrogen, and R d  is \u2014OCH 2 CH 2 N(CH 3 ) 2 ; or \n when \n Ar is not wherein\n W and Z are each CH, R b  is methoxy, R c  is hydrogen, and R d  is \u2014SCH 2 CH 2 N(CH 3 ) 2 ; or \n when \n Ar is not wherein\n W and Z are each CH, R b  is \u2014OCH 2 C(O)OR wherein R is H or alkyl, R c  is hydrogen, and R d  is \u2014Sethyl; or \n when \n Ar is not wherein W and Z are each CH, R b  is ethoxy, R c  is hydrogen, and R d  is \u2014SCH 2 CH 2 N(CH 3 ) 2 .

Metadata:
- Claim Count in Document: 49.0
- Percentile: 93.0
- Lexical Diversity: 1.1875
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13996483', '15222734', '15619671', '15331777', '14204076']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7293801234885664
- 35 USC 102 Novelty (BERT): 0.5133769911191639
- Combined Prediction Score: 0.7077798102516262
- Mean Citation Score: 251.510662
- Max Citation Score: 263.77826
- Similarity Product: 162.07793284687162

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test