PATENT CLAIM ANALYSIS

Application Number: 16250042
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-08
Patent Classification: ["435", "006140"]

Abstract:
The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based upon the values, predicting the expected benefit including disease-free survival and/or overall survival for the patient without treatment (beyond the surgical removal of tumor tissue) or with a particular treatment and using that information to select a treatment regimen for the subject. High risk subject is identified by high levels of both uPA and PAI-1, high level of uPA and low level of PAI-1 or, low level of uPA and high level of PAI-1. Treatment options for high risk subjects include, but are not limited to, adjuvant CMF chemotherapy, adjuvant non-CMF chemotherapy, adjuvant endocrine therapy, adjuvant anthracyclin-containing chemotherapy, radiation therapy, and gene therapy. Treatment options for low risk subjects include, but are not limited to, no treatment, radiation, and adjuvant endocrine therapy.

Claim (Index 99):
The method of  claim 98  wherein said comparable population is defined by nodal status, number of nodes affected, tumor size, tumor grade, patient's age, hormone receptor status, and menopausal status.

Metadata:
- Claim Count in Document: 73.0
- Percentile: 99.0
- Lexical Diversity: 2.24719
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11965323', '13841887', '13682377', '11450896', '13256910']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5697462151913959
- 35 USC 102 Novelty (BERT): 0.5242545757026085
- Combined Prediction Score: 0.5651970512425172
- Mean Citation Score: 265.043356
- Max Citation Score: 321.6257
- Similarity Product: 193.73240868430733

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test