PATENT CLAIM ANALYSIS

Application Number: 15759484
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "571000"]

Abstract:
The invention relates to a method for the diagnosis of non-alcoholic steatohepatitis (NASH), for determining the activity, the stage, or the severity of NASH or for classifying a subject as a potential receiver or non receiver of a treatment of NASH using circulating miRNAs and other blood circulating markers of liver damage, e.g. alpha 2 macroglobulin, HbA1c, N-terminal pro-peptide of collagen type III, miR-34 and miR-200. It also relates to a kit for implementing the method of the invention, and the compounds for use in a method for the treatment of NASH, wherein the subject to be treated is identified, evaluated or classified according to the method of the invention.

Claim (Index 15):
The method according to  claim 14 , wherein the treatment comprises administering to the subject a compound of formula (I): wherein:\n X1 represents a halogen, a R1, or G1-R1 group; \n A represents a CH\u2550CH or a CH2-CH2 group; \n X2 represents a G2-R2 group; \n G1 and G2, identical or different, represent an atom of oxygen or sulfur; \n R1 represents a hydrogen atom, an unsubstituted alkyl group, an aryl group or an alkyl group that is substituted by one or more halogen atoms, an alkoxy or an alkylthio group, cycloalkyl groups, cycloalkylthio groups or heterocyclic groups; \n R2 represents an alkyl group substituted by at least a \u2014COOR3 group, wherein R3 represents a hydrogen atom, or an alkyl group that is substituted or not by one or more halogen atoms, cycloalkyl groups, or heterocyclic groups. \n R4 and R5, identical or different, representing an alkyl group that is substituted or not by one or more halogen atoms, cycloalkyl groups, heterocyclic groups; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 90.0
- Lexical Diversity: 1.92308
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15550416', '11855792', '15318646', '15320208', '13387314']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7684504561036319
- 35 USC 102 Novelty (BERT): 0.5100425598729795
- Combined Prediction Score: 0.7426096664805667
- Mean Citation Score: 223.135226
- Max Citation Score: 241.80423
- Similarity Product: 150.8807117278701

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test