PATENT CLAIM ANALYSIS

Application Number: 16138369
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["514", "252030"]

Abstract:
The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like). Specifically, the present invention provides a compound or an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or the like, the compound represented by formula (I):

Claim (Index 23):
A compound which is selected from:\n 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(1-methyl-1H-pyrazol-4-yl)-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(3-methyl-6-phenyl-5\u2032-(trifluoromethyl)-[2,3\u2032-bipyridin]-5-yl)urea, 1-(3,6\u2032-dimethyl-6-phenyl-[2,3\u2032-bipyridin]-5-yl)-3-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)urea, 1-(6\u2032-cyano-3-methyl-6-phenyl-[2,3\u2032-bipyridin]-5-yl)-3-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(3-methyl-6\u2032-(methylsulfonyl)-6-phenyl-[2,3\u2032-bipyridin]-5-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-2-phenyl-6-(2-(trifluoromethyl)pyrimidin-5-yl)pyridin-3-yl)urea, 1-(6-(4-cyanophenyl)-5-methyl-2-phenylpyridin-3-yl)-3-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(3-methyl-6-phenyl-2\u2032-(trifluoromethyl)-[2,4\u2032-bipyridin]-5-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-2-phenyl-6-(1H-pyrazol-4-yl)pyridin-3-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(6-(2-hydroxypyrimidin-5-yl)-5-methyl-2-phenylpyridin-3-yl)urea, 1-(6\u2032-hydroxy-3-methyl-6-phenyl-[2,3\u2032-bipyridin]-5-yl)-3-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-5-methyl-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(1-methyl-1H-pyrazol-4-yl)-2-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)urea, 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(1H-pyrazol-4-yl)-2-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)urea, 1-(6\u2032-hydroxy-3-methyl-6-(tetrahydro-2H-pyran-4-yl)-[2,3yl)-bipyridin]-5-yl)-3-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)urea, 1-((1R,2R)-7-fluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-6-fluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(6-(4-(hydroxymethyl)phenyl)-5-methyl-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(6-(3-(hydroxymethyl)phenyl)-5-methyl-2-phenylpyridin-3-yl)urea, 1-(6-(3-cyanophenyl)-5-methyl-2-phenylpyridin-3-yl)-3-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(1-methyl-1H-pyrazol-3-yl)-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(6-methylpyridazin-4-yl)-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylthiazol-5-yl)-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(1-methyl-1H-pyrazol-4-yl)-2-phenylpyridin-3-yl)urea, 1-(6-(4-cyanophenyl)-5-methyl-2-phenylpyridin-3-yl)-3-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-2-phenyl-6-(1H-pyrazol-4-yl)pyridin-3-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-5-methyl-2-phenylpyridin-3-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(6\u2032-(hydroxymethyl)-3-methyl-6-phenyl-[2,3\u2032-bipyridin]-5-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(2\u2032-(hydroxymethyl)-3-methyl-6-phenyl-[2,4\u2032-bipyridin]-5-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)urea, 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(1H-pyrazol-4-yl)-2-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)urea, and 1-((1R,2R)-6,7-difluoro-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(6-(2-hydroxypyrimidin-5-yl)-5-methyl-2-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)urea, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or optical isomers.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 97.0
- Lexical Diversity: 1.89706
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['11988659', '13392350', '13008456', '14442609', '14601775']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.767853116725249
- 35 USC 102 Novelty (BERT): 0.5243678619689882
- Combined Prediction Score: 0.743504591249623
- Mean Citation Score: 301.63904999999994
- Max Citation Score: 317.48358
- Similarity Product: 252.78503655323627

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test