PATENT CLAIM ANALYSIS

Application Number: 15564214
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-12
Patent Classification: ["424", "009360"]

Abstract:
Provided is a probe for detecting in vivo hydrogen sulfide, specifically, a probe for detecting hydrogen sulfide including a complex compound into which a radioactive isotope Cu is introduced. According to specific embodiments of the present disclosure, as a result of real-time observing animal models, in which hydrogen sulfide involved in various diseases is generated in a large quantity, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present disclosure may selectively bind with hydrogen sulfide to provide images of a site where hydrogen sulfide has abnormally increased in a cell or a tissue, thereby detecting a disease in an unexpected site without affecting the anatomical properties of the body. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, thereby solving the existing problem of waiting a predetermined time for testing after an imaging agent is injected. Accordingly, the probe may be effectively used as a means for diagnosing diseases, such as a composition for imaging, an imaging method, etc.

Claim (Index 1):
A probe for detecting hydrogen sulfide (H 2 S), comprising a radioactive isotope Cu-introduced complex compound which is represented by any one of the following Chemical Formulae 1 to 4: (wherein X 1 , X 2  and X 3  are each independently one or more selected from N, O, and S; Y 1  and Y 2  are each independently C or N; A and B are each independently one or more selected from no bond, C(R 9 )(R 10 )\u2014C(R 11 )(R 12 )\u2014, \u2550C(R 9 )\u2014C(R 10 )(R 11 )\u2014C(R 12 )(R 13 )\u2014, and C(R 9 )(R 10 )\u2014C(R 11 )(R 12 )\u2014C(R 13 )(R 14 )\u2014, and \u2550C(R 9 )\u2014C(R 10 )\u2550; R 1  to R 14  are each independently one or more selected from no bond, hydrogen, hydroxy, substituted or unsubstituted C 1 -C 6  linear or branched alkyl, substituted or unsubstituted C 1 -C 6  linear or branched alkyloxycarbonyl, substituted or unsubstituted C 5 -C 12  aryl C 1 -C 6  alkyl, substituted or unsubstituted C 5 -C 12  heterocycloalkyl, substituted or unsubstituted C 5 -C 20  aryl, substituted or unsubstituted C 5 -C 20  arylsulfonyl, C 1 -C 6  alkylamine, C 1 -C 6  dialkylamine, and substituted or unsubstituted amine, the \u2018substituted\u2019 means being substituted with one or more substituents selected from hydroxy, hydroxy C 1 -C 6  alkyl, C 1 -C 6  dialkylamine, nitro, and  64 Cu-labeled 3-methyl-1,4,7,10-tetraazacyclotridecane, R 5  and R 8  or R 6  and R 7  bind to each other to form a C 4 -C 8  cycloalkyl ring; --- is a single bond or a double bond, Cu is any one selected from  60 Cu,  61 Cu,  62 Cu,  64 Cu, and  67 Cu); (wherein K, L and M, are each independently one or more selected from C(R 18 )(R 19 )\u2014C(R 20 )(R 21 )\u2014, \u2550C(R 18 )\u2014C(R 19 )(R 20 )\u2014C(R 21 )(R 22 )\u2014, C(R 18 )(R 19 )\u2014C(R 20 )(R 21 )\u2014C(R 22 )(R 23 )\u2014, and \u2550C(R 18 )\u2014C(R 19 )\u2550; R 15  to R 23  are each independently one or more selected from no bond, hydrogen, hydroxy, substituted or unsubstituted C 1 -C 20  linear or branched alkyl, substituted or unsubstituted C 1 -C 6  linear or branched alkyloxycarbonyl, substituted or unsubstituted C 5 -C 12  aryl C 1 -C 6  alkyl, substituted or unsubstituted C 5 -C 12  heterocycloalkyl, substituted or unsubstituted C 5 -C 20  aryl, substituted or unsubstituted C 5 -C 20  arylsulfonyl, C 1 -C 6  alkylamine, C 1 -C 6  dialkylamine, and substituted or unsubstituted amine, the \u2018substituted\u2019 means being substituted with one or more substituents selected from hydroxy, hydroxy C 1 -C 6  alkyl, C 1 -C 6  dialkylamine, nitro, and  64 Cu-labeled 3-methyl-1,4,7,10-tetraazacyclotridecane; Cu is any one selected from  60 Cu,  61 Cu,  62 Cu,  64 Cu, and  67 Cu); (wherein X is hydrogen or a compound represented by the following Chemical Formula)

Metadata:
- Claim Count in Document: 35.0
- Percentile: 88.0
- Lexical Diversity: 1.94792
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13520408', '14176260', '15313274', '13992080', '12418116']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7132859035304375
- 35 USC 102 Novelty (BERT): 0.4941643072515992
- Combined Prediction Score: 0.6913737439025537
- Mean Citation Score: 212.683218
- Max Citation Score: 224.69508
- Similarity Product: 158.0987639484215

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test