PATENT CLAIM ANALYSIS

Application Number: 16326976
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["546", "113000"]

Abstract:
Provided are a PDE4 inhibitor and a use thereof in the preparation of a medicament for treating PDE4 related diseases. Specifically disclosed are the compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.

Claim (Index 1):
A compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, wherein, X is selected from O, N(R 3 ), \u2014CH(R 3 )\u2014; R 3  is selected from H, F, Cl, Br, I, OH, CN, NH 2 , COOH, R 4 -L 1 -, or selected from the group consisting of C 1-6  alkyl, C 1-6  heteroalkyl, C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R; R 4  is selected from the group consisting of C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R; L 1  is selected from \u2014CH 2 \u2014, \u2014CH 2 CH 2 \u2014, O, S, NH, \u2014C(\u2550O)\u2014; R 1  and R 2  are each independently selected from H, F, Cl, Br, I, OH, CN, NH 2 , R 5 -L 2 -, or selected from the group consisting of C 1-6  alkyl, C 1-6  alkoxy, C 1-6  alkylthio, C 1-6  alkylamino, C 2-6  alkenyl, C 3-6  cycloalkenyl, 3-6 membered heterocycloalkenyl, C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R; R 5  is selected from the group consisting of C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl, 3-6 membered heterocycloalkenyl, phenyl and 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R; L 2  is selected from \u2014CH 2 \u2014, \u2014CH 2 CH 2 \u2014, O, S, NH; R 6  is selected from C 1-3  alkyl, which is optionally substituted by 1, 2 or 3 R; R is selected from H, halogen, OH, NH 2 , CN, or selected from the group consisting of C 1-6  alkyl and C 1-6  heteroalkyl, each of which is optionally substituted by 1, 2 or 3 R\u2032; R\u2032 is selected from H, F, Cl, Br, I, OH, NH 2 , Me, Et, CF 3 , CHF 2 , CH 2 F, NHCH 3 , N(CH 3 ) 2 ; the \u201chetero\u201d in the C 1-6  heteroalkyl, 3-6 membered heterocycloalkyl, 5-6 membered heteroaryl and 3-6 membered heterocycloalkenyl is selected from \u2014C(\u2550O)NH\u2014, \u2014NH\u2014, \u2014C(\u2550NH)\u2014, \u2014S(\u2550O) 2 NH\u2014, \u2014S(\u2550O)NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2550O, \u2550S, \u2014O\u2014N\u2550, \u2014C(\u2550O)O\u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, \u2014S(\u2550O)\u2014, \u2014S(\u2550O) 2 \u2014 and \u2014NHC(\u2550O)NH\u2014; in any of the above cases, the number of the heteroatom or the heteroatom group is independently selected from 1, 2, 3.

Metadata:
- Claim Count in Document: 31.0
- Percentile: 99.0
- Lexical Diversity: 1.33333
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16325626', '16317510', '16476797', '16087861', '15812142']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8213563741281786
- 35 USC 102 Novelty (BERT): 0.5407315136272552
- Combined Prediction Score: 0.7932938880780863
- Mean Citation Score: 372.804462
- Max Citation Score: 383.89105
- Similarity Product: 341.92637437478004

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test