PATENT CLAIM ANALYSIS

Application Number: 16030466
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["435", "129000"]

Abstract:
The invention relates to amino acid sequence variants of a lipase with improved activity for catalyzing synthesis reactions and methods of preparing the variants. The methods include predicting amino acid sites for change based on computational models of the protein structure in non-aqueous conditions, and expressing the protein in a prokaryotic host for subsequent purification and use. The enzyme sequence variants described have a three to nine-fold improvement in synthesis activity over the parent protein sequence.

Claim (Index 49):
The nucleic acid of  claim 48 , wherein the CALB variant comprises an amino acid sequence of SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 12, SEQ ID NO: 14, SEQ ID NO: 16, SEQ ID NO: 18, SEQ ID NO: 20 or SEQ ID NO: 22.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 95.0
- Lexical Diversity: 1.56863
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14961237', '13410486', '10527438', '12264006', '15108074']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6270536699197286
- 35 USC 102 Novelty (BERT): 0.5543020569189993
- Combined Prediction Score: 0.6197785086196557
- Mean Citation Score: 275.40042000000005
- Max Citation Score: 434.7149
- Similarity Product: 344.49420615330934

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test