PATENT CLAIM ANALYSIS

Application Number: 16060146
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-09
Patent Classification: ["514", "255050"]

Abstract:
The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt signaling pathway, and provides a method for preparing such a compound, and the use of such a compound in preparing a medicament that antagonizes the Wnt signaling pathway. The five-membered heterocyclic amide WNT pathway inhibitor provided by the invention has a remarkable anti-tumor activity based on a target-based rational drug design of, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

Claim (Index 4):
The five-membered heterocyclic amide Wnt pathway inhibitor according to  claim 2  having the following general structural formula, or a pharmaceutically acceptable salt thereof: wherein X, Y and Z are each independently selected from one of a group consisting of CR 4 , NR 5 , S atom and O atom, and the S atom and O atom are not present simultaneously; n is selected from 1 or 2; R 1  and R 2  is selected from one of a group consisting of hydrogen, halogen, C 1-6  alkyl, C 1-6  alkoxy, halogenated C 1-6  alkyl, halogenated C 1-6  alkoxy, amido, C 1-6  alkylamido, and heterocyclyl; R 3  is selected from one of a group consisting of R 4  and R 5  are each independently selected from one of a group consisting of hydrogen, C 1-6  alkyl, halogenated C 1-6  alkyl, C 1-6  alkoxy, and halogenated C 1-6  alkoxy; R 6  is selected from one of a group consisting of hydrogen, halogen, C 1-6  alkyl, halogenated C 1-6  alkyl, C 1-6  alkoxy, halogenated C 1-6  alkoxy, and amido group; and the heterocyclyl is a 3-6 membered heterocyclic ring containing one or more atom(s) selected from a group consisting of N and O atoms.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 94.0
- Lexical Diversity: 1.83051
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15699112', '13948038', '13132294', '12263949', '14214185']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.803838674253604
- 35 USC 102 Novelty (BERT): 0.5347104419215972
- Combined Prediction Score: 0.7769258510204033
- Mean Citation Score: 331.698596
- Max Citation Score: 350.51352
- Similarity Product: 234.41537650348664

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test