PATENT CLAIM ANALYSIS

Application Number: 15765980
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "263100"]

Abstract:
The disclosure provides methods of using inhibitors of chaperone proteins, such as HSP90 inhibitors, in combination with agents that increase proteotoxic stress on tumor cells or agents that induce a biochemical rewiring of the chaperome. The proteotoxic agents are administered prior to administration of the chaperone proteins to achieve synergistic activity.

Claim (Index 25):
A method of treating cancer by administering a combination of a proteotoxic stressor and an HSP90 inhibitor over a cycle of between 7 and 31 days, wherein the proteotoxic stressor and the HSP90 inhibitor are administered at least once over said cycle, and wherein each administration of said proteotoxic stressor is followed by administration of said HSP90 inhibitor.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 91.0
- Lexical Diversity: 1.375
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14131423', '14048540', '15103187', '15940055', '14005186']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7387665140721635
- 35 USC 102 Novelty (BERT): 0.5430035651968936
- Combined Prediction Score: 0.7191902191846365
- Mean Citation Score: 303.88358
- Max Citation Score: 395.372
- Similarity Product: 258.19424611210826

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test