PATENT CLAIM ANALYSIS

Application Number: 15870014
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["548", "101000"]

Abstract:
The present invention relates to intermediates of Formula I and to methods of synthesizing and purifying calicheamicin derivatives.

Claim (Index 137):
A method of synthesizing a compound of Formula II wherein R 12  is selected from straight and branched-chain C 1 -C 8  alkyl; each R 10  is independently selected from hydrogen, R 12  and \u2014OR 12 ; R 8  and R 9  are each independently selected from hydrogen and straight and branched-chain C 1 -C 8  alkyl, wherein each said alkyl for R 8  and R 9  is independently optionally substituted by \u2014NH 2 , \u2014NHR 11 , \u2014NR 11 R 13 , \u2014OR 11 , \u2014OH, or \u2014SR 11 , wherein each R 11  and each R 13  are independently selected from straight and branched-chain C 1 -C 5  alkyl; r is an integer selected from 0 and 1; and G is oxygen or sulfur; which method comprises treating a compound of Formula VII wherein R 16  is \u2014C(\u2550O)OH or \u2014C(\u2550V)SH, wherein V is oxygen or sulfur, or R 16  is \u2014NH 2 ; with an azole activating agent of Formula IX wherein V\u2032 is oxygen or sulfur; and wherein E is wherein m is an integer 0, 1, 2, or 3; q is an integer 0, 1 or 2; and p is an integer 0, 1, 2, 3, or 4; and wherein each R 17  attached to E is independently selected from straight and branched-chain (C 1 -C 6 )alkyl groups; in an organic solvent to form a compound of Formula VIII wherein when R 16  is \u2014C(\u2550O)OH, r is 0 and G is oxygen; when R 16  is \u2014C(\u2550V)SH, r is 0 and G is V; and when R 16  is \u2014NH 2 , r is 1 and G is V\u2032; followed by combining the compound of Formula VIII with hydrazine, thereby forming a compound of Formula II.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 86.0
- Lexical Diversity: 1.1875
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15030563', '12583237', '14711267', '14286708', '10355125']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7755368320761492
- 35 USC 102 Novelty (BERT): 0.56682870920076
- Combined Prediction Score: 0.7546660197886103
- Mean Citation Score: 321.8862180000001
- Max Citation Score: 441.5852
- Similarity Product: 428.825033869052

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test