PATENT CLAIM ANALYSIS

Application Number: 16073934
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-05
Patent Classification: ["514", "403000"]

Abstract:
Disclosed are compounds of formula I, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising a compound of formula I, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by aberrant complement system activity.

Claim (Index 1):
A compound represented by Formula (I), or a pharmaceutically acceptable salt thereof: wherein, independently for each occurrence: R 1  represents optionally substituted aryl, heteroaryl, cycloalkyl, heterocycloalkyl, alkyl, or alkenyl; R 2  and R 3  each independently represent H, F, or optionally substituted alkyl, alkenyl, alkynyl, alkoxyalkyl, haloalkyl, hydroxyalkyl, (alkylthio)alkyl, aralkyl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, or (heterocycloalkyl)alkyl; or R 2  and R 3 , taken together with the carbon atom to which they are bonded, form an optionally substituted cycloalkyl or heterocycloalkyl ring; R 4  represents H or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, aralkyl, heteroaralkyl, hydroxyalkyl, or haloalkyl; X represents NH, CH 2 , CHF, CF 2 , CH(C 1 -C 6 )alkyl, or C((C 1 -C 6 )alkyl) 2 ; Y is absent or represents CH 2 , C(O), CR 15 R 16 , S(O) 2 , or optionally substituted (C 3 -C 7 )cycloalkylene, arylene, or heteroarylene; R a  represents H or optionally substituted (C 1 -C 6 )alkyl, (heterocycloalkyl)alkyl, or (C 3 -C 7 )cycloalkyl; m is an integer from 1-6; n is 0 or 1; R 15  and R 16  are each independently selected from the group consisting of H, hydroxy, halogen, \u2014C(O)OR 17 , \u2014OR 17 , \u2014C(O)NR 17 R 18 , \u2014NR 17 R 18 , alkyl, hydroxyalkyl, haloalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, and (heterocycloalkyl)alkyl, wherein alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, and (heterocycloalkyl)alkyl are optionally substituted with one or more substituents selected from the group consisting of \u2014CN, \u2014OR 17 , \u2014NR 17 R 18 , halo, and alkyl; or R 15  and R 16  may be taken together with the intervening atom to form an optionally substituted carbocyclic or heterocyclic ring; R 17  and R 18  are each independently selected from the group consisting of H, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, and (heterocycloalkyl)alkyl; or R 17  and R 18 , when attached to the same atom, may be taken together with the intervening atom to form an optionally substituted heterocyclic ring; represents Z 1  and Z 3  each independently represent C or N; Z 2  represents N, CH, or CF; Z 4  represents N or CR 8 ; Z 5  represents N or CR 5 ; Z 6  represents N or CR 6 ; Z 7  represents N or CR 9 ; Z 8  and Z 9  each independently represent N or CR 19 ; R 5  and R 6  each independently represent H, halogen, \u2014CN, \u2014NO 2 , \u2014OR 13 , \u2014NR 13 R 14 , \u2014C(O)R 13 , \u2014C(O)OR 13 , \u2014C(O)NR 13 R 14 , \u2014OC(O)R 13 , \u2014NR 13 C(O)R 14 , \u2014OC(O)NR 13 R 14 , \u2014OC(O)OR 13 , \u2014NR 13 C(O)OR 14 , \u2014NR 13 C(O)NR 13 R 14 , \u2014OS(O) p (R 13 ), \u2014NR 13 S(O) p (R 14 ), or optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, aralkyl, heteroaralkyl, heteroaryl, aryl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, or (heterocycloalkyl)alkyl; L represents \u2014H, \u2014CN, \u2014C(O)R 7 , \u2014CH(OH)R 7 , or \u2014S(O) p (alkyl); R 7 , independently for each occurrence, represents H, NH 2 , CH 3 , OH, CF 3 , CH 2 OH, (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, NH(C 1 -C 6 )alkyl, N((C 1 -C 6 )alkyl) 2 ; R 8  and R 9  each independently represent H, halogen, \u2014OR 13 , \u2014NR 13 R 14 , \u2014C(O)R 13 , \u2014C(O)OR 13 , \u2014C(O)NR 13 R 14 , \u2014OC(O)R 13 , \u2014NR 13 C(O)R 14 , \u2014OC(O)NR 13 R 14 , \u2014OC(O)OR 13 , \u2014NR 13 C(O)OR 14 , \u2014NR 13 C(O)NR 13 R 14 , \u2014OS(O) p (R 13 ), \u2014NR 13 S(O) p (R 14 ), or optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, aralkyl, heteroaralkyl, heteroaryl, or aryl; or R 5  and R 8 , or R 5  and R 6 , or R 6  and R 9  may be taken together with the intervening atoms to form an optionally substituted heterocyclic or carbocyclic ring; R 13  and R 14 , independently for each occurrence, represent H or optionally substituted alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, or (heterocycloalkyl)alkyl; or, when R 13  and R 14  are attached to the same atom, R 13  and R 14  taken together with the atom may form an optionally substituted heterocyclic ring; R 19 , independently for each occurrence, represents H, F, CN, \u2014C(O)R 7 , \u2014CH(OH)R 7 , or \u2014S(O) p (alkyl); J represents H or NH 2 ; and p is 0, 1, or 2; wherein, if Z 1  is N, or if represents then X represents CH 2 .

Metadata:
- Claim Count in Document: 29.0
- Percentile: 95.0
- Lexical Diversity: 1.59459
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15764071', '15247429', '14631828', '15905524', '15700550']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8099935188601405
- 35 USC 102 Novelty (BERT): 0.5636692665921227
- Combined Prediction Score: 0.7853610936333387
- Mean Citation Score: 398.325606
- Max Citation Score: 429.99738
- Similarity Product: 385.9944797678304

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test