PATENT CLAIM ANALYSIS

Application Number: 16193407
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["424", "009600"]

Abstract:
The teachings provide active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Methods of making and using the systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

Claim (Index 1):
An enhanced active agent, comprising:\n a drug conjugated to a delivery system to form a conjugated drug, the delivery system including\n a ligand that is selective for transthyretin in the serum of a subject; and, \n a linker configured for operatively attaching the ligand covalently to the drug, the linker selected to cause release of the drug from the transthyretin in the subject as the conjugated drug, wherein the linker ranges from 14-20 angstroms in length; \n wherein, the delivery system has a structure comprising: where,\n n is 1 to 8; \n R 1  and R 3  are independently selected from a short chain alkyl having 1 to 4 carbon atoms; \n R 2  is selected from the group consisting of a hydrogen, a short chain alkyl having 1 to 4 carbon atoms, and an aryl; \n X a  is C(R 4 )(R 5 ), O, N\u2014R 5 , or S; where R 4  and R 5  are independently selected from hydrogen, an alkyl having 1 to 4 carbon atoms, a substituted alkyl, an alkoxy, hydroxyl, an alkoxycarbonyl, an amino; \n R a  is CHO, COOH, COOCH 3 , COOR 6 , CONR 7 R 8 , tetrazolyl, CONHOH, B(OH) 2 , CONHSO 2 Ar, CONHCH(R 9 )COOH, halogen, acyl, substituted acyl, carboxyl, heterocyclic group, sulfonamide, sulfonyl fluoride, thioester, alkoxycarbonyl or substituted alkoxycarbonyl; \n R b  is the linker and is positioned ortho or meta to R a , the linker including a CHO, COOH, COOCH 3 , COOR 6 , CONR 7 R 8 , tetrazolyl, CONHOH, B(OH) 2 , CONHSO 2 Ar, CONHCH(R 9 )COOH, CF 3 , hydrogen, halogen, alkyl, substituted alkyl, acyl, substituted acyl, carboxyl, heterocyclic group, sulfonamide, sulfonyl fluoride, ester, thioester, ether, thioether, triazolyl, alkoxycarbonyl or substituted alkoxycarbonyl; \n R 6  is alkyl, haloalkyl, cycloalkyl, or heterocyclyl; \n R 7  and R 8  are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, or heteroaryl; and, \n R 9  is the side chain of a naturally occurring \u03b1-amino carboxylic acid; \n or, a pharmaceutically acceptable salt, ester, enol ether, enol ester, amide, acetal, ketal, orthoester, hemiacetal, hemiketal, hydrate, solvate or prodrug thereof.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 98.0
- Lexical Diversity: 1.82
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15446212', '14000594', '14166719', '13415790', '11178736']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6443403126526699
- 35 USC 102 Novelty (BERT): 0.6692846705668183
- Combined Prediction Score: 0.6468347484440848
- Mean Citation Score: 331.6680760000001
- Max Citation Score: 680.1484
- Similarity Product: 621.4176100488663

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test