PATENT CLAIM ANALYSIS

Application Number: 15940055
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["514", "092000"]

Abstract:
A pharmaceutical combination comprising a platinum-containing anticancer agent, and an Hsp90 inhibitor according to the following formulae (I) & (Ia), a tautomer, or a pharmaceutically acceptable salt thereof, wherein the variables structural formulae are defined herein. Also provided is a method of treating a proliferative disorder such as cancer in a subject in need thereof, using the pharmaceutical combination described herein.

Claim (Index 1):
A pharmaceutical composition comprising a platinum-containing anti-cancer agent and an Hsp90 inhibitor according to the following formulae: or a tautomer, or a pharmaceutically acceptable salt thereof, wherein: Z is OH, SH, or NH 2 ; X is CR 4  or N; R 1  is \u2014H, \u2014OH, \u2014SH, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, halo, cyano, nitro, guanidino, a haloalkyl, a heteroalkyl, an alkoxy or cycloalkoxy, a haloalkoxy, \u2014NR 10 R 11 , \u2014OR 7 , \u2014C(O)R 7 , \u2014C(O)OR 7 , \u2014C(S)R 7 , \u2014C(O)SR 7 , \u2014C(S)SR 7 , \u2014C(S)OR 7 , \u2014C(S)NR 10 R 11 , \u2014C(NR 8 )OR 7 , \u2014C(NR 8 )R 7 , \u2014C(NR 8 )NR 10 R 11 , \u2014C(NR 8 )SR 7 , \u2014OC(O)R 7 , \u2014OC(O)OR 7 , \u2014OC(S)OR 7 , \u2014OC(NR 8 )OR 7 , \u2014SC(O)R 7 , \u2014SC(O)OR 7 , \u2014SC(NR 8 )OR 7 , \u2014OC(S)R 7 , \u2014SC(S)R 7 , \u2014SC(S)OR 7 , \u2014OC(O)NR 10 R 11 , \u2014OC(S)NR 10 R 11 , \u2014OC(NR 8 )NR 10 R 11 , \u2014SC(O)NR 10 R 11 , \u2014SC(NR 8 )NR 10 R 11 , \u2014SC(S)NR 10 R 11 , \u2014OC(NR 8 )R 7 , \u2014SC(NR 8 )R 7 , \u2014C(O)NR 10 R 11 , \u2014NR 8 C(O)R 7 , \u2014NR 7 C(S)R 7 , \u2014NR 7 C(S)OR 7 , \u2014NR 7 C(NR 8 )R 7 , \u2014NR 7 C(O)OR 7 , \u2014NR 7 C(NR 8 )OR 7 , \u2014NR 7 C(O)NR 10 R 11 , \u2014NR 7 C(S)NR 10 R 11 , \u2014NR 7 C(NR 8 )NR 10 R 11 , \u2014SR 7 , \u2014S(O) p R 7 , \u2014OS(O) p R 7 , \u2014OS(O) p OR 7 , \u2014OS(O) p NR 10 R 11 , \u2014S(O) p OR 7 , \u2014NR 8 S(O) p R 7 , \u2014NR 7 S(O) p NR 10 R 11 , \u2014NR 7 S(O) p OR 7 , \u2014S(O) p NR 10 R 11 , \u2014SS(O) p R 7 , \u2014SS(O) p OR 7 , \u2014SS(O) p NR 10 R 11 , \u2014OP(O)(OR 7 ) 2 , or \u2014SP(O)(OR 7 ) 2 ; R 2  is \u2014H, \u2014OH, \u2014SH, \u2014NR 7 H, \u2014OR 15 , \u2014SR 15 , \u2014NHR 15 , \u2014O(CH 2 ) m OH, \u2014O(CH 2 ) m SH, \u2014O(CH 2 ) m NR 7 H, \u2014S(CH 2 ) m OH, \u2014S(CH 2 ) m SH, \u2014S(CH 2 ) m NR 7 H, \u2014OC(O)NR 10 R 11 , \u2014SC(O)NR 10 R 11 , \u2014NR 7 C(O)NR 10 R 11 , \u2014OC(O)R 7 , \u2014SC(O)R 7 , \u2014NR 7 C(O)R 7 , \u2014OC(O)OR 7 , \u2014SC(O)OR 7 , \u2014NR 7 C(O)OR 7 , \u2014OCH 2 C(O)R 7 , \u2014SCH 2 C(O)R 7 , \u2014NR 7 CH 2 C(O)R 7 , \u2014OCH 2 C(O)OR 7 , \u2014SCH 2 C(O)OR 7 , \u2014NR 7 CH 2 C(O)OR 7 , \u2014OCH 2 C(O)NR 10 R 11 , \u2014SCH 2 C(O)NR 10 R 11 , \u2014NR 7 CH 2 C(O)NR 10 R 11 , \u2014OS(O) p R 7 , \u2014SS(O) p R 7 , \u2014NR 7 S(O) p R 7 , \u2014OS(O) p NR 10 R 11 , \u2014SS(O) p NR 10 R 11 , \u2014NR 7 S(O) p NR 10 R 11 , \u2014OS(O) p OR 7 , \u2014SS(O) p OR 7 , \u2014NR 7 S(O) p OR 7 , \u2014OC(S)R 7 , \u2014SC(S)R 7 , \u2014NR 7 C(S)R 7 , \u2014OC(S)OR 7 , \u2014SC(S)OR 7 , \u2014NR 7 C(S)OR 7 , \u2014OC(S)NR 10 R 11 , \u2014SC(S)NR 10 R 11 , \u2014NR 7 C(S)NR 10 R 11 , \u2014OC(NR 8 )R 7 , \u2014SC(NR 8 )R 7 , \u2014NR 7 C(NR 8 )R 7 , \u2014OC(NR 8 )OR 7 , \u2014SC(NR 8 )OR 7 , \u2014NR 7 C(NR 8 )OR 7 , \u2014OC(NR 8 )NR 10 R 11 , \u2014SC(NR 8 )NR 10 R 11 , or \u2014NR 7 C(NR 8 )NR 10 R 11 ; R 3  is \u2014H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, hydroxyalkyl, alkoxyalkyl, a haloalkyl, a heteroalkyl, \u2014C(O)R 7 , \u2014(CH 2 ) m C(O)OR 7 , \u2014C(O)OR 7 , \u2014OC(O)R 7 , \u2014C(O)NR 10 R 11 , \u2014S(O) p R 7 , \u2014S(O) p OR 7 , or \u2014S(O) p NR 10 R 11 ; R 4  is \u2014H, \u2014OH, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, hydroxyalkyl, alkoxyalkyl, halo, cyano, nitro, guanidino, a haloalkyl, a heteroalkyl, \u2014C(O)R 7 , \u2014C(O)OR 7 , \u2014OC(O)R 7 , \u2014C(O)NR 10 R 11 , \u2014NR 8 C(O)R 7 , \u2014SR 7 , \u2014S(O) p R 7 , \u2014OS(O) p R 7 , \u2014S(O) p OR 7 , \u2014NR 8 S(O) p R 7 , \u2014S(O) p NR 10 R 11 , or R 3  and R 4  taken together with the carbon atoms to which they are attached form an optionally substituted cycloalkenyl, an optionally substituted aryl, an optionally substituted heterocyclyl, or an optionally substituted heteroaryl; R 7  and R 8 , for each occurrence, are, independently, \u2014H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; R 10  and R 11 , for each occurrence, are independently \u2014H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; or R 10  and R 11 , taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl; R 15 , for each occurrence, is independently, a lower alkyl; p, for each occurrence, is, independently, 1 or 2; and m, for each occurrence, is independently, 1, 2, 3, or 4.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 90.0
- Lexical Diversity: 1.38462
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14356232', '14131183', '14355684', '12604970', '12601729']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7645113190697631
- 35 USC 102 Novelty (BERT): 0.5514771785285492
- Combined Prediction Score: 0.7432079050156417
- Mean Citation Score: 369.691532
- Max Citation Score: 430.3388
- Similarity Product: 377.6378656401157

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test