PATENT CLAIM ANALYSIS

Application Number: 15903783
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["435", "029000"]

Abstract:
The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.

Claim (Index 66):
A dye, having the formula: wherein: G is -L-TL, where TL is a targeting ligand comprising at least one binding moiety that binds to a biological target; L has the formula: E is absent or S; Q is (CH 2 ) q  or a non-ionic oligomeric or polymeric solubilizing moiety; J is C(o), C(O)O, or C(O)NH; R 17 , R 18 , R 19 , and R 12  are independently selected from H, an ionic group, a non-ionic oligomeric or polymeric solubilizing group, halo, cyano, nitro, C 1-4  alkyl, C 1-4  alkoxy, and C 1-4  haloalkyl; q is 0, 1, 2, 3, 4, 5, 6, 7, or 8; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8  are independently selected from H, an ionic group, a non-ionic oligomeric or polymeric solubilizing group, halo, C 1-6  alkyl, aryl, and heteroaryl, wherein said alkyl, aryl, and heteroaryl groups are optionally substituted with 1, 2, 3, 4, or 5 groups independently selected from halo, cyano, nitro, and C 1-4  haloalkyl; or two adjacent R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8  groups, together with the atoms to which they are attached, form a fused 5-7 membered aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group, each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, cyano, nitro, and C 1-4  haloalkyl; R 9 , and R 10 , are independently selected from an ionic group, a non-ionic oligomeric or polymeric solubilizing group, C 1-6  alkyl, aryl, and heteroaryl, wherein said alkyl, aryl, and heteroaryl groups are optionally substituted with 1, 2, 3, 4, or 5 groups independently selected from halo, cyano, nitro, and C 1-4  haloalkyl; R 11  and R 12  are independently selected from C 1-4  alkyl optionally substituted with 1, 2, or 3 halo; R 13  and R 14  are independently selected from C 1-4  alkyl optionally substituted with 1, 2, or 3 halo; R 15  and R 16  are independently selected from H and C 1-6  alkyl; R 22 , R 23 , R 24 , R 25 , R 26 , and R 27  are independently selected from independently an ionic group, a non-ionic oligomeric or polymeric solubilizing group, halo, C 1-6  alkyl, aryl, and heteroaryl; and v is 0, 1, 2, 3, 4, or 5, wherein at least one of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10  is an ionic group, or an ester thereof, which permits covalent conjugation of the fluorophore to targeting ligands.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 88.0
- Lexical Diversity: 1.07143
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14681068', '15633233', '13148137', '15633349', '14215979']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5688736150173959
- 35 USC 102 Novelty (BERT): 0.5524589100685063
- Combined Prediction Score: 0.5672321445225069
- Mean Citation Score: 305.764818
- Max Citation Score: 410.91003
- Similarity Product: 347.3758103194553

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test