PATENT CLAIM ANALYSIS

Application Number: 15747867
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-01
Patent Classification: ["514", "250000"]

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Claim (Index 8):
The compound of  claim 3 , or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein:\n L is independently selected from ring A is R 1  and R 2  are independently selected from H, C 1-4  alkyl, and OH; R 3  is independently selected from \u2014(CH 2 ) n \u2014NR a R a , \u2014(CH 2 ) n \u2014C(\u2550O)R b , \u2014(CH 2 ) n \u2014C(\u2550O)OR b , \u2014(CH 2 ) n \u2014NR a C(\u2550O)OR b , \u2014(CH 2 ) n \u2014NR a C(\u2550O)R b , \u2014NR a C(\u2550O)NR a R a , \u2014C(\u2550O)NR a R a ; R 3a  is H; alternatively, R 3a  and R 3  are taken together to form a heterocyclic ring selected from R 3b  is independently selected from H, C 1-4  alkyl, \u2014C(\u2550O)C 1-4 alkyl, \u2014(CH 2 ) n \u2014C(\u2550O)OH, \u2014(CH 2 ) n \u2014C(\u2550O)OC 1-4 alkyl, \u2014C(\u2550O)NR a R a , and \u22124- to 6-membered heterocyclyl substituted with 1-5 R 5 ; R 3c  is independently selected from H and \u2550O; is independently selected from R 5 , at each occurrence, is independently selected from H, \u2014C(\u2550O)OC 1-4 alkyl, OC 1-4 alkyl; R 7  is independently selected from H and C 1-3  alkyl; R a , at each occurrence, is independently selected from H, C 1-6  alkyl substituted with 0-5 R e , C 2-6  alkenyl substituted with 0-5 R e , C 2-6  alkynyl substituted with 0-5 R e , \u2014(CH 2 ) n \u2014C 3-10 carbocyclyl substituted with 0-5 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-5 R e ; R b , at each occurrence, is independently selected from H, C 1-6  alkyl substituted with 0-5 R e , \u2014(CH 2 ) n \u2014C 3-10 carbocyclyl substituted with 0-5 R e , and \u2014(CH 2 ) n -heterocyclyl substituted with 0-5 R e ; R e , at each occurrence, is independently selected from F, Cl, Br, CN, NO 2 , \u2550O, C 1-6  alkyl, haloalkyl, \u2014(CH 2 ) n \u2014C 3-6  cycloalkyl, \u2014(CH 2 ) n -aryl, \u2014(CH 2 ) n -heterocyclyl, and CO 2 H; and n, at each occurrence, is an integer independently selected from 0, 1, 2, and 3.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 86.0
- Lexical Diversity: 1.27778
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15115314', '15747818', '15750212', '15735322', '14942013']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7858774154419054
- 35 USC 102 Novelty (BERT): 0.5936894534680184
- Combined Prediction Score: 0.7666586192445166
- Mean Citation Score: 394.471142
- Max Citation Score: 496.5713
- Similarity Product: 443.740606128788

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test