PATENT CLAIM ANALYSIS

Application Number: 15770138
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "394000"]

Abstract:
The invention provides a pharmaceutical composition for injection comprising a NL-101 type compound and a preparation method thereof. The composition uses the NL-101 type compound as an active pharmaceutical ingredient, and the stability of the NL-101 type compound is improved by adding a chloride-containing stabilizing agent or using a co-solvent containing hydrochloric acid, so that the formulation can be stably produced and meet the requirements for clinical safe use.

Claim (Index 5):
The pharmaceutical composition according to  claim 1 , characterized in that the compound of the formula (I) or the compound of the formula (II) or NL-101 or a pharmaceutically acceptable salt thereof has a mass volume percentage concentration of 0.1-5.0%, preferably 0.2-2.0%, further preferably 0.5-1.0%, still further preferably 0.5%;\n preferably, the stabilizing agent has a mass volume percentage concentration of 0.4-10.0%, further preferably 0.9-8.0%, still further preferably 1.0-7.0%, still further preferably 2.0-6.0%, still further preferably 3.0-5.0%; preferably, the co-solvent has a mass volume percentage concentration of 0.5-25.0%, further preferably 1.0-20.0%, still further preferably 1.0-10.0%, still further preferably 1.25-5.0%; preferably, the lyophilizing protectant has a mass volume percentage concentration of 2.0-35.0%, further preferably 5.0-30.0%, still further preferably 10.0-20.0%; preferably, the pH of the composition is 3.0-7.0, further preferably 4.0-6.0, still further preferably 5.0.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 91.0
- Lexical Diversity: 1.43137
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14345562', '13746999', '12762025', '14538464', '14030692']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7717548681995162
- 35 USC 102 Novelty (BERT): 0.513880571638609
- Combined Prediction Score: 0.7459674385434255
- Mean Citation Score: 226.71752
- Max Citation Score: 266.564
- Similarity Product: 170.86017628979684

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test