PATENT CLAIM ANALYSIS

Application Number: 16111842
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["544", "358000"]

Abstract:
Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC 50  value below 5 μM against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo, and led to 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.

Claim (Index 19):
A compound of structural Formula III: or a salt thereof, wherein: each of Z 1  and Z 3  is independently chosen from a bond, C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 5 -C 10  aryl, C 5 -C 10  heteroaryl, arylalkyl, heteroarylalkyl, alkylaryl, alkylheteroaryl, heterocycloalkylalkyl, alkylheterocycloalkyl, cycloalkylalkyl, alkylcycloalkyl, \u2014(CH 2 ) a (OCH 2 CH 2 ) b (CH 2 ) c \u2014, \u2014(CH 2 ) a N(R 1 )(CH 2 ) c \u2014, \u2014(CH 2 ) a N(R 1 )C(O)(CH 2 ) c \u2014, \u2014(CH 2 ) a (C(O)N(R 1 )(CH 2 ) c \u2014, \u2014(CH 2 ) a N(R\u2032)C(O)N(R 1 )(CH 2 ) c \u2014; Z 2  is chosen from C 1 -C 10  alkyl, C 1 -C 10  alkenyl, C 1 -C 10  alkynyl, C 5 -C 10  aryl, C 5 -C 10  heteroaryl, arylalkyl, heteroarylalkyl, alkylaryl, alkylheteroaryl, heterocycloalkylalkyl, alkylheterocycloalkyl, cycloalkylalkyl, alkylcycloalkyl, \u2014(CH 2 ) a (OCH 2 CH 2 ) b (CH 2 ) c \u2014, and \u2014(CH 2 ) a (CH 2 CH 2 O) b (CH 2 ) c \u2014, \u2014(CH 2 ) a O(CH 2 ) c \u2014, \u2014(CH 2 ) a S(CH 2 ) c \u2014, \u2014(CH 2 ) a N(R 1 ) (CH 2 ) c \u2014, \u2014(CH 2 ) a N(R 1 )C(O)(CH 2 ) c \u2014, \u2014(CH 2 ) a C(O)N(R\u2032)(CH 2 ) c \u2014, \u2014(CH 2 ) a N(R\u2032)C(O)N(R\u2032)(CH 2 ) c \u2014; wherein each of Z 1 , Z 2 , and Z 3  can be optionally substituted with one or more groups chosen from halo, oxo, and C 1 -C 10  alkyl; each R 1  is independently chosen from hydrogen, C 1 -C 10  alkyl, and C 1 -C 10  acyl; each a and c is an integer independently chosen from 0, 1, 2, 3, and 4; each b is an integer independently chosen from 1, 2, 3, 4, 5, and 6; and Y is chosen from

Metadata:
- Claim Count in Document: 50.0
- Percentile: 96.0
- Lexical Diversity: 1.45833
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15301188', '13302409', '14414669', '11883092', '15100967']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7170268944534242
- 35 USC 102 Novelty (BERT): 0.5641458105315893
- Combined Prediction Score: 0.7017387860612406
- Mean Citation Score: 256.96285
- Max Citation Score: 439.8415
- Similarity Product: 348.78528344047066

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test