PATENT CLAIM ANALYSIS

Application Number: 15876698
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "278000"]

Abstract:
The present invention provides, in part, heterocyclic spiro compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein:\n ring A 1  is C 4-7  cycloalkyl or 4- to 7-membered heterocycloalkyl; \n R 1  is R 1A  or R 1B ; \n R 1A  is 1,1,1,3,3,3-hexafluoropropan-2-yl-; \n R 1B  is 2,5-dioxopyrrolidin-1-yl-, which is optionally substituted with 1, 2, 3, or 4 substituents each independently selected from the group consisting of the group consisting of halogen, C 1-4  alkyl, C 1-4  haloalkyl, C 3-4  cycloalkyl, C 3-4  cycloalkyl-C 1-2  alkyl-, C 1-4  alkoxy, and C 1-4  haloalkoxy; \n each R 2  is independently selected from the group consisting of halogen, C 1-4  alkyl, C 1-4  haloalkyl, C 3-4  cycloalkyl, C 3-4  cycloalkyl-C 1-2  alkyl-, C 1-4  alkoxy, and C 1-4  haloalkoxy; \n each R 3  is independently selected from the group consisting of \u2014OH, oxo, halogen, \u2014CN, C 1-4  alkyl, C 1-4  haloalkyl, C 3-4  cycloalkyl, C 3-4  cycloalkyl-C 1-2  alkyl-, C 1-4  alkoxy, and C 1-4  haloalkoxy; \n R 4  is selected from the group consisting of R 6 , \u2014N(R 5 )(C(\u2550O)R 6 ), \u2014N(R 5 )(S(\u2550O) 2 R 6 ), \u2014C(\u2550O)\u2014R 6 , \u2014S(\u2550O) 2 R 6 , \u2014NR 5 R 6 , \u2014SO 2 NR 5 R 6 , and \u2014OR 6 ; \n R 5  is selected from the group consisting of H, C 1-4  alkyl, C 3-4  cycloalkyl, and C 3-4  cycloalkyl-C 1-2  alkyl-; \n R 6  is selected from the group consisting of C 1-6  alkyl, C 3-10  cycloalkyl, 4- to 10-membered heterocycloalkyl, C 6-10  aryl, 5- to 10-membered heteroaryl, (C 3-10  cycloalkyl)-C 1-4  alkyl-, (4- to 10-membered heterocycloalkyl)-C 1-4  alkyl-, (C 6-10  aryl)-C 1-4  alkyl-, and (5- to 10-membered heteroaryl)-C 1-4  alkyl-, wherein each of the selections is optionally substituted with one or more substituents each independently selected from the group consisting of halogen, \u2014CN, oxo, \u2014OH, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  hydroxylalkyl, C 3-4  cycloalkyl, C 3-4  cycloalkyl-C 1-2  alkyl-, C 1-4  alkoxy, C 1-4  haloalkoxy, \u2014C(\u2550O)C 1-4  alkyl, \u2014C(\u2550O)OH, \u2014C(\u2550O)O\u2014C 1-4  alkyl, \u2014C(\u2550O)NHC 1-4  alkyl, \u2014C(\u2550O)N(C 1-4  alkyl) 2 , \u2014OC(\u2550O)\u2014C 1-4  alkyl, \u2014OC(\u2550O)O\u2014C 1-4  alkyl, \u2014NH 2 , \u2014NH(C 1-4  alkyl), \u2014N(C 1-4  alkyl) 2 , \u2014NHC(\u2550O)C 1-4  alkyl, \u2014NHC(\u2550O)OC 1-4  alkyl, and \u2014NHC(\u2550O)NHC 1-4  alkyl; \n t1 is 0, 1, or 2; \n t2 is 0, 1, 2, 3, or 4; and \n t3 is 0 or 1.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 86.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15874987', '15221658', '14902324', '15808242', '11127878']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8123828821439751
- 35 USC 102 Novelty (BERT): 0.550343783127943
- Combined Prediction Score: 0.786178972242372
- Mean Citation Score: 371.852396
- Max Citation Score: 404.64084
- Similarity Product: 317.1091111266518

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test