PATENT CLAIM ANALYSIS

Application Number: 15745187
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "210210"]

Abstract:
The present disclosure relates to 2-arylamino pyridine, pyrimidine, or triazine derivatives, and the preparation method and use thereof. The 2-arylamino pyridine, pyrimidine, or triazine derivatives may act on certain mutated forms of epidermal growth factor receptor, for example the L858R activating mutant, the delE746_A750 mutant, the Exon19 deletion activating mutant, and the T790M resistance mutant, so as to be used for treatment and prevention of diseases and medical conditions. The 2-arylamino pyridine, pyrimidine, or triazine derivatives may be used for treatment and prevention of cancer. The present disclosure also relates to a pharmaceutical composition comprising 2-arylamino pyridine, pyrimidine, or triazine derivatives, intermediates useful in the manufacture of 2-arylamino pyridine, pyrimidine, or triazine derivatives, and to methods of treatment of diseases mediated by various different forms of EGFR using 2-arylamino pyridine, pyrimidine, or triazine derivatives.

Claim (Index 9):
The compound according to  claim 1 , or a pharmaceutically acceptable salt or a solvate thereof, wherein the compound represented by the formula (I) is selected from any one of the following compounds: N-(5-((4-(benzo[d]isoxazol-3-yl)pyrimidin-2-yl)amino)-4-(difluoromethoxy)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide, N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide, N-(4-(difluoromethoxy)-2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide, N-(4-(difluoromethoxy)-2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-thieno[3,2-c]pyrrol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide, N-(5-((4-(1H-indol-7-yl)-1,3,5-triazin-2-yl)amino)-4-(difluoromethoxy)-2-((2-(dimethylamino)ethyl)(methyl)amino)phenyl)acrylamide, N-(4-(difluoromethoxy)-2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,5-triazin-2-yl)amino)phenyl)acrylamide, N-(5-((4-(benzo[d]isoxazol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide, N-(2-((2-(dimethylamino)ethyl)methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-thieno[3,2-c]pyrrol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide, or N-(5-((4-(1H-indol-7-yl)-1,3,5-triazin-2-yl)amino)-2-((2-(dimethylamino)ethyl)methyl)amino)-4-methoxyphenyl)acrylamide.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 86.0
- Lexical Diversity: 2.39394
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15329044', '12223180', '13505235', '10628093', '14647940']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8296238434193509
- 35 USC 102 Novelty (BERT): 0.5621835393621496
- Combined Prediction Score: 0.8028798130136309
- Mean Citation Score: 427.42446
- Max Citation Score: 440.52466
- Similarity Product: 385.5346197977698

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test