PATENT CLAIM ANALYSIS

Application Number: 15771920
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "252050"]

Abstract:
Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment or prevention of mGluR5 mediated disorders, such as acute and/or chronic neurological disorders, cognitive disorders and memory deficits, as well as acute and chronic pain.

Claim (Index 1):
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein: R 1  is a 5- to 10-membered mono- or bicyclic heteroaryl ring that contains 1-3 heteroatoms selected from the group consisting of N, O and S, wherein the 5- to 10-membered ring system is optionally substituted with 0-3 substituents independently selected from alkyl, halogen, \u2014OH, \u2014CN, nitro, \u2014CF 3 , \u2014O\u2014CF 3 , \u2014O-alkyl, \u2014O-aryl, \u2014S-alkyl, \u2014S-aryl, \u2014S(O)-alkyl, \u2014S(O)-aryl, \u2014S(O 2 )-alkyl, \u2014S(O 2 )-aryl, \u2014CH 2 -aryl, aryl, heteroaryl, \u2014O\u2014CH 2 -aryl, \u2014N(CH 3 ) 2 , cycloalkyl, heterocycloalkyl, \u2014C(O)-alkyl, \u2014C(O)cycloalkyl, \u2014C(O)heterocycloalkyl, \u2014C(O)-aryl, \u2014C(O)-heteroaryl, \u2014C(O)O-alkyl, \u2014C(O)O-cycloalkyl, \u2014C(O)O-heterocycloalkyl, \u2014C(O)O-aryl, \u2014C(O)O-heteroaryl, \u2014C(O)N-alkyl, \u2014C(O)N-cycloalkyl, \u2014C(O)N-heteroalkyl, \u2014C(O)N-aryl, \u2014C(O)N-heteroaryl or substituted lower alkyl, wherein the substituents may combine to form an optionally substituted 5-7 membered fused and optionally substituted carbocyclic or heterocyclic ring; R 2  is alkanoyl, arylalkanoyl, herteroaryl acyl, aryl sulfonyl, heteroaryl sulfonyl, alkoxycarbonyl, \u2014C(O)O-aryl, arylalkoxycarbonyl, acylamino, wherein the aryl or heteroaryl are optionally substituted with 0-3 substituents independently selected from alkyl, halogen, \u2014OH, \u2014CN, nitro, \u2014CF 3 , \u2014OCF 3 , \u2014O-alkyl, \u2014O-aryl, \u2014S-alkyl, \u2014S-aryl, \u2014S(O)-alkyl, S(O)-aryl, \u2014S(O 2 )-alkyl, \u2014S(O 2 )aryl, \u2014CH 2 -aryl, heteroaryl, \u2014O\u2014CH 2 -aryl, \u2014N(CH 3 ) 2 , cycloalkyl, heterocycloalkyl, \u2014C(O)-alkyl, \u2014C(O)cycloalkyl, \u2014C(O)-heterocycloalkyl, \u2014C(O)-aryl, \u2014C(O)-heteroaryl, \u2014C(O)O-alkyl, \u2014C(O)O-cycloalkyl, \u2014C(O)O-heterocycloalkyl, \u2014C(O)O-aryl, \u2014C(O)O-heteroaryl, \u2014C(O)N-alkyl, \u2014C(O)N-cycloalkyl, \u2014C(O)N-heteroalkyl, \u2014C(O)N-aryl, \u2014C(O)N-heteroaryl or substituted lower alkyl, wherein the substituents may combine to form an optionally substituted 5-7 membered fused carbacyclic or heterocyclic ring; or a 5- to 10-membered mono- or bicyclic heteroaryl ring that contains 1-3 heteroatoms selected from the group consisting of N, O and S, wherein the 5- to 10-membered ring system is optionally substituted with 0-3 substituents independently selected from alkyl, halogen, \u2014OH, \u2014CN, nitro, \u2014CF 3 , \u2014O\u2014CF 3 , \u2014O-alkyl, \u2014O-aryl, \u2014S-alkyl, \u2014S-aryl, \u2014S(O)-alkyl, \u2014S(O)-aryl, \u2014S(O 2 )-alkyl, \u2014S(O 2 )-aryl, \u2014CH 2 -aryl, aryl, heteroaryl, \u2014O\u2014CH 2 -aryl, \u2014N(CH 3 ) 2 , cycloalkyl, heterocycloalkyl, \u2014C(O)-alkyl, \u2014C(O)cycloalkyl, \u2014C(O)heterocycloalkyl, \u2014C(O)-aryl, \u2014C(O)-heteroaryl, \u2014C(O)O-alkyl, \u2014C(O)O-cycloalkyl, \u2014C(O)O-heterocycloalkyl, \u2014C(O)O-aryl, \u2014C(O)O-heteroaryl, \u2014C(O)N-alkyl, \u2014C(O)N-cycloalkyl, \u2014C(O)N-heteroalkyl, \u2014C(O)N-aryl, \u2014C(O)N-heteroaryl or substituted lower alkyl, wherein the substituents may combine to form an optionally substituted 5-7 membered fused and optionally substituted carbocyclic or heterocyclic ring; or a 5- to 10-membered mono- or bicyclic aryl ring, wherein the 5- to 10-membered ring system is optionally substituted with 0-3 substituents independently selected from alkyl, halogen, \u2014OH, \u2014CN, nitro, \u2014CF 3 , \u2014OCF 3 , \u2014O-alkyl, \u2014O-aryl, \u2014S-alkyl, \u2014S-aryl, \u2014S(O)-alkyl, S(O)-aryl, \u2014S(O 2 )-alkyl, \u2014S(O 2 )aryl, \u2014CH 2 -aryl, aryl, heteroaryl, \u2014O\u2014CH 2 -aryl, \u2014N(CH 3 ) 2 , cycloalkyl, heterocycloalkyl, \u2014C(O)-alkyl, \u2014C(O)cycloalkyl, \u2014C(O)-heterocycloalkyl, \u2014C(O)-aryl, \u2014C(O)-heteroaryl, \u2014C(O)O-alkyl, \u2014C(O)O-cycloalkyl, \u2014C(O)O-heterocycloalkyl, \u2014C(O)O-aryl, \u2014C(O)O-heteroaryl, \u2014C(O)N-alkyl, \u2014C(O)N-cycloalkyl, \u2014C(O)N-heteroalkyl, \u2014C(O)N-aryl, \u2014C(O)N-heteroaryl or substituted lower alkyl, wherein the substituents may combine to form an optionally substituted 5-7 membered fused carbacyclic or heterocyclic ring.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 91.0
- Lexical Diversity: 1.57447
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16091781', '14267011', '14122519', '15041375', '14379134']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7850115159383788
- 35 USC 102 Novelty (BERT): 0.5315926174976044
- Combined Prediction Score: 0.7596696260943014
- Mean Citation Score: 329.751104
- Max Citation Score: 353.16312
- Similarity Product: 340.5614824302292

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test