PATENT CLAIM ANALYSIS

Application Number: 15771043
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-02
Patent Classification: ["514", "021300"]

Abstract:
The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

Claim (Index 28):
A method of increasing the in vivo half-life of a polypeptide improving the blood-brain barrier permeability or oral bioavailability as compared to the corresponding non-chemically modified polypeptide, wherein the method comprises at least one the following chemical modifications:\n (i) chemically modifying at least one substituent selected from the group consisting of an N-terminus amino group, the NH group of the N-terminus first internal amide bond, other free primary amino group, thiol group and thioether group of the polypeptide, wherein each chemical modification independently comprises derivatizing the substituent with an optionally substituted C 1 -C 16  alkyl, optionally substituted C 3 -C 16  cycloalkyl, optionally substituted C 3 -C 16  aryl, optionally substituted C 2 -C 16  alkenyl or optionally substituted C 2 -C 16  alkynyl, and (ii) chemically modifying at least one substituent selected from the N-terminus amino group and the NH of the independently comprises derivatizing the substituent with the group X, wherein each occurrence of X is independently selected from the group consisting of optionally substituted phenyl, optionally substituted benzyl, optionally substituted \u2014(CR 2 ) 1-6 -phenyl, \u2192O, \u2014OH, alkoxy, NH 2 , NH(C 1 -C 16  alkyl) and N(C 1 -C 6  alkyl)(C 1 -C 16  alkyl), where R is independently selected at each occurrence from hydrogen or optionally substituted C 1 -C 16  alkyl.

Metadata:
- Claim Count in Document: 39.0
- Percentile: 91.0
- Lexical Diversity: 1.59524
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12845455', '13130962', '14182706', '13697021', '12066324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7936440414541134
- 35 USC 102 Novelty (BERT): 0.5080664477403026
- Combined Prediction Score: 0.7650862820827323
- Mean Citation Score: 258.376928
- Max Citation Score: 264.86304
- Similarity Product: 176.57432331590653

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test