PATENT CLAIM ANALYSIS

Application Number: 15869549
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "195000"]

Abstract:
This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.

Claim (Index 28):
A method of treating a subject suffering from Mucopolysaccharidosis type IVa (MPS IVa) or Morquio A syndrome, or Multiple Sulfatase Deficiency (MSD), comprising administering to the subject a therapeutically effective amount of a purified, recombinant human N-acetylgalactosamine-6-sulfatase (GALNS) enzyme or biologically active mutant, variant or derivative thereof, wherein said GALNS or biologically active mutant, variant or derivative thereof:\n (a) has a purity of at least about 90% as determined by Coomassie Blue staining when subjected to SDS-PAGE under non-reducing conditions; (b) has at least about 90% conversion of the cysteine residue at position 53 to C-formylglycine (FGly); and (c) is N-linked glycosylated at the asparagine residues at positions 178 and 397, wherein at least about 50% of the oligomannose chains attached to the asparagine residue at position 178 are bis-phosphorylated.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.58537
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12355453', '14281538', '13188907', '14573907', '14924405']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7428478674178773
- 35 USC 102 Novelty (BERT): 0.6643653666232586
- Combined Prediction Score: 0.7349996173384155
- Mean Citation Score: 709.8492980000003
- Max Citation Score: 756.8287
- Similarity Product: 618.4488852218033

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test