PATENT CLAIM ANALYSIS

Application Number: 16048677
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["544", "106000"]

Abstract:
The present invention provides MDM2 inhibitor compounds of Formula I, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Claim (Index 1):
A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein, X is O or \u2014S(\u2550O) 2 \u2014; R 1  is hydrogen, C 1-6 alkyl, \u2014(CR e R e ) n C 6-8 aryl, \u2014(CR e R e ) n C 3-8 cycloalkyl, \u2014(CR e R e ) n 3-8 membered heterocycloalkyl, \u2014S(\u2550O) 2 C 3-8 cycloalkyl, \u2014C(\u2550O)C 3-8 cycloalkyl, or wherein any heteroaryl or heterocycloalkyl group has one or more heteroatoms independently selected from O, N or S, and wherein any cycloalkyl, heterocycloalkyl, heteroaryl or aryl group can be unsubstituted or substituted with from 1 to 3 substituents independently selected from C 1-6 alkyl, halo, \u2014CN, \u2014CF 3 , \u2014SR e , \u2014S(\u2550O) 2 R e , \u2014CHF 2 , \u2014CH 2 F, \u2014NR e R e , \u2014OCF 3 , \u2014OCHF 2 , \u2014OCH 2 F, or \u2014OR e ; Q is \u2014(CR e R e ) n C 6-8 aryl, \u2014(CR e R e ) n 3-8 membered heterocycloalkyl, \u2014(CR e R e ) n 5-8 membered heteroaryl, \u2014(CR e R e ) n C 3-8 cycloalkyl, \u2014CN, \u2014(CR e R e ) n OH, \u2014C(\u2550O)OH, \u2014NR e R e , \u2014(CR e R e ) n OR e , \u2014C(\u2550O)N(R e )S(\u2550O) 2 R e , \u2014C(\u2550O)NR e R e , \u2014C(\u2550O)NR e (CR e R e ) n C(\u2550O)OR e , \u2014C(\u2550O)NR e (CR e R e ) n C(\u2550O)NR e R e , \u2014N(R e )(CR e R e ) n C(\u2550O)OR e , \u2014OC(\u2550O)NR e R e , \u2014S(\u2550O) 2 C 3-8 cycloalkyl, \u2014C(\u2550O)N(R e )(CR e R e ) n OH, \u2014C(\u2550O)N(R e )(CR e R e ) n 3-8 membered heterocycloalkyl, \u2014N(R e )C(\u2550O)(CR e R e ) n OH, \u2014N(R e )S(\u2550O) 2 R e , \u2014N(R e )C(\u2550O)(CR e R e ) n C(\u2550O)OR e , \u2014C(\u2550O)3-8 membered heterocycloalkyl, \u2014S(\u2550O) 2 3-8 membered heterocycloalkyl, \u2014C(\u2550O)N(R e )S(\u2550O) 2 C 3-8 cycloalkyl, \u2014O(CR e R e ) n C(\u2550O)R e , \u2014C(\u2550O)N(R e )(CR e R e ) n 5-8 membered heteroaryl, \u2014N(R e )C(\u2550O)(CR e R e ) n 5-8 membered heteroaryl, \u2014C(\u2550O)3-8 membered heterocycloalkyl(CR e R e ) n  C(\u2550O)OR e , or \u2014C(\u2550O)(CR e R e ) n C(\u2550O)OR e , wherein any heteroaryl or heterocycloalkyl group has one or more heteroatoms independently selected from O, N or S, and wherein any cycloalkyl, heterocycloalkyl, heteroaryl or aryl group can be unsubstituted or substituted with from 1 to 3 substituents independently selected from C 1-6 alkyl, halo, \u2014CN, \u2014SR e , \u2014C(\u2550O)OR e , \u2014CF 3 , \u2014S(\u2550O) 2 R e , \u2014CHF 2 , \u2014CH 2 F, \u2014NR e R e , \u2014OCF 3 , \u2014OCHF 2 , \u2014OCH 2 F, or \u2014OR e ; R 2  is hydrogen, C 1-6 alkyl, \u2014(CR e R e ) n C(\u2550O)OR e , \u2014(CR e R e ) n NR e R e , \u2014(CR e R e ) n C(\u2550O)NR e R e , \u2014(CR e R e ) n OH, \u2014(CR e R e ) n C(\u2550O)H, \u2014(CR e R e ) n C 6-8 aryl, \u2014(CR e R e ) n 3-8 membered heterocycloalkyl, \u2014(CR e R e ) n 5-8 membered heteroaryl, \u2014(CR e R e ) n CN, \u2014(CR e R e ) n C(\u2550O)5-8 membered heterocycloalkyl, \u2014(CR e R e ) n C(\u2550O)N(R e )(CR e R e ) n 3-8 membered heterocycloalkyl, \u2014(CR e R e ) n \u2014CH(OH)CH 2 OH, \u2014CH\u2550CH5-8 membered heteroaryl, \u2014(CR e R e ) n CH\u2550CR e R e , \u2014(CR e R e ) n OS(\u2550O) 2 C 1-6 alkyl, \u2014(CR e R e ) n OS(\u2550O)OR e , or \u2014(CR e R e ) n OC(\u2550O)NR e R e , wherein any heteroaryl or heterocycloalkyl group has one or two heteroatoms independently selected from O, N or S, and wherein any cycloalkyl, heterocycloalkyl, heteroaryl or aryl group can be unsubstituted or substituted with from 1 to 3 substituents independently selected from C 1-6 alkyl, halo, \u2014(CR e R e ) n halo, \u2014OC 1-6 alkyl, \u2014OCF 3 , \u2014OCF 2 H, \u2014OCFH 2 , \u2014CN, \u2014S(\u2550O) 2 CF 3 , \u2014C(\u2550O)NR e R e , \u2014C(\u2550O)OR e , C 6-8 aryl, 5-8 membered heteroaryl, \u2014CF 3 , \u2014SR e , \u2014S(\u2550O) 2 R e , \u2014CHF 2 , \u2014CH 2 F, \u2014NR e R e , or \u2014OR e ; R 3  is hydrogen or C 1-6 alkyl; R 4  is C 6-8 aryl or 5-9 membered heteroaryl, wherein any heteroaryl group has one or more heteroatom independently selected from O, N or S, and wherein the aryl or heteroaryl group is substituted with from 1 to 3 substituents independently selected from C 1-6 alkyl, halo, \u2014CF 3 , \u2014CN, C 3-8 cycloalkyl, \u2014SR e , \u2014S(\u2550O) 2 R e , \u2014CHF 2 , \u2014CH 2 F, \u2014NR e R e , \u2014OCF 3 , \u2014OCHF 2 , \u2014OCH 2 F, or \u2014OR e ; R 5  is C 6-8 aryl or 5-9 membered heteroaryl, wherein any heteroaryl group has one or more heteroatom independently selected from O, N or S, and wherein the aryl or heteroaryl group is substituted with from 1 to 3 substituents independently selected from C 1-6 alkyl, halo, \u2014CF 3 , \u2014CN, C 3-8 cycloalkyl, \u2014SR e , \u2014S(\u2550O) 2 R e , \u2014CHF 2 , \u2014CH 2 F, \u2014NR e R e , \u2014OCF 3 , \u2014OCHF 2 , \u2014OCH 2 F, or \u2014OR e ; R 6  is hydrogen or C 1-6 alkyl; R 7  is hydrogen or C 1-6 alkyl; each R a  is independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, \u2014(CR e R e ) n C 3-8 cycloalkyl, or \u2014(CR e R e ) n C 6-8 aryl, wherein any cycloalkyl or aryl group can be unsubstituted or substituted with from 1 to 3 substituents independently selected from C 1-6 alkyl, halo, \u2014CN, \u2014SR e , \u2014C(\u2550O)OR e \u2014CF 3 , \u2014S(\u2550O) 2 R e , \u2014CHF 2 , \u2014CH 2 F, \u2014NR e R e , \u2014OCF 3 , \u2014OCHF 2 , \u2014OCH 2 F, or \u2014OR e ; each R e  is independently hydrogen, C 1-6 alkyl, or \u2014OH; each R f  is independently hydrogen, C 1-6 alkyl, or \u2014OH; each n is independently 0, 1, 2, 3 or 4; and each m is independently 0, 1, 2, 3 or 4, provided that R 2  and R 3  are not both hydrogen.

Metadata:
- Claim Count in Document: 55.0
- Percentile: 95.0
- Lexical Diversity: 1.35
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14347628', '15047523', '13308287', '12228421', '10131938']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8332458874665157
- 35 USC 102 Novelty (BERT): 0.5468445045918816
- Combined Prediction Score: 0.8046057491790523
- Mean Citation Score: 412.642012
- Max Citation Score: 422.45053
- Similarity Product: 326.2222620141262

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test