PATENT CLAIM ANALYSIS

Application Number: 15753317
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["506", "004000"]

Abstract:
Systems, kits, and methods for detecting and quantifying proteomic activity using DNA-encoded probes are provided, where the proteomic activity may be enzymatic activity or ligand binding affinity. Such systems and methods encode quantitative proteomic activity information into DNA sequence populations and utilize DNA-linked substrates or ligands as activity probes. The systems, kits, and methods that are directed to detecting ligand affinity further include crosslinking steps to ensure the integrity of the DNA-linked ligands during purification and washing. Signal detection involves the chemical manipulation of a probe population downstream of sample exposure and application of purifying, selective pressure for desired products. Selection-induced changes in DNA abundance between the initial pool and the purified pool indicate sample activity.

Claim (Index 47):
The method of  claim 44 , wherein the reactive group is selected from a group consisting of: tosyl, N-hydroxysuccinimide ester, sulfonyl fluoride, diazirine, and phenyl azide.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 88.0
- Lexical Diversity: 1.60759
- Patent Class: 506.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14239369', '15080767', '14786185', '14900604', '14346913']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6240421954386469
- 35 USC 102 Novelty (BERT): 0.5041785717031447
- Combined Prediction Score: 0.6120558330650967
- Mean Citation Score: 231.68102
- Max Citation Score: 239.79802
- Similarity Product: 154.34163506430392

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test