PATENT CLAIM ANALYSIS

Application Number: 15765980
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "263100"]

Abstract:
The disclosure provides methods of using inhibitors of chaperone proteins, such as HSP90 inhibitors, in combination with agents that increase proteotoxic stress on tumor cells or agents that induce a biochemical rewiring of the chaperome. The proteotoxic agents are administered prior to administration of the chaperone proteins to achieve synergistic activity.

Claim (Index 1):
A method of treating cancer by administering to a cancer patient an inhibitor of HSP90 following pretreatment with a proteotoxic stressor, wherein the proteotoxic stressor is administered at a sufficient time prior to administration of the HSP90 inhibitor to increase the formation of the epichaperome.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 91.0
- Lexical Diversity: 1.375
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14131423', '14048540', '15103187', '15940055', '14005186']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7375719600762615
- 35 USC 102 Novelty (BERT): 0.544778764960001
- Combined Prediction Score: 0.7182926405646355
- Mean Citation Score: 303.88358
- Max Citation Score: 395.372
- Similarity Product: 297.00173411273965

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test