PATENT CLAIM ANALYSIS

Application Number: 16105203
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["435", "194000"]

Abstract:
The present invention relates to the construction of a new class of Targeted Secretion Inhibitors (TSIs), which comprise a non-cytotoxic protease, translocation peptide and a targeting moiety peptide, wherein the targeting moiety peptide has a free N-terminal domain and a free C-terminal domain; to a single-chain fusion protein precursor thereof, and to a method of activating said single-chain fusion protein precursor.

Claim (Index 10):
The nucleic acid of  claim 1 , wherein the targeting moiety of the fusion protein comprises a peptide selected from the group consisting of: a gonadotropin-releasing hormone (GnRH) peptide, an opioid peptide, a beta-endorphin peptide, a bradykinin peptide, a BAM peptide, a nociceptin peptide, a dynorphin peptide, a galanin peptide, an enkephalin peptide, a substance P peptide, a corticotropin-releasing factor (CRF) peptide, a gastrin-releasing peptide (GRP), a Neuromedin B peptide, a bombesin peptide, a gastrin peptide, a CCK peptide, a somatostatin (SST) peptide, a cortistatin (CST) peptide, a growth hormone releasing hormone (GHRH) peptide, a PAR peptide, a parathyroid hormone (PTH) peptide, a vasointestinal peptide (VIP), a beta, adrenoreceptor agonist peptide, a gastrin-releasing peptide, a calcitonin gene related peptide, a thyroid stimulating hormone (TSH) peptide, an insulin peptide, an insulin-like growth factor peptide, a gonadorelin peptide, a corticotrophin releasing hormone (CRH) peptide, an adrenocorticotropic hormone (ACTH) peptide, and a pituitary adenyl cyclase activating peptide (PACAP).

Metadata:
- Claim Count in Document: 1.0
- Percentile: 96.0
- Lexical Diversity: 1.60465
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14117286', '13774587', '12862948', '13738235', '13239573']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6863643037778245
- 35 USC 102 Novelty (BERT): 0.5776026673702136
- Combined Prediction Score: 0.6754881401370635
- Mean Citation Score: 420.549464
- Max Citation Score: 466.78696
- Similarity Product: 437.3313486834764

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test