PATENT CLAIM ANALYSIS

Application Number: 16045594
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "365000"]

Abstract:
[Problem] Provided is a novel 1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, or a solvate thereof, which is useful as an anti-HIV agent. [Solving Means] The present invention provides a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

Claim (Index 1):
A compound represented by the following formula [I]or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein\n R 1  is \n (1) a C 1-6  alkyl group optionally substituted by the same or different 1 to 5 substituents selected from\n (i) a C 3-8  cycloalkyl group, and \n (ii) a C 1-6  alkoxy group, \n \n (2) a C 3-8  cycloalkyl group, or \n (3) a saturated monocyclic heterocyclic group containing, besides carbon atom, 1 to 3 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, \n R 2 , R 3 , R 4  and R 5  are the same or different and each is \n (1) a hydrogen atom, \n (2) a carboxyl group, \n (3) \u2014CO\u2014NR a R b  wherein R a  and R b  are the same or different and each is\n (i) a hydrogen atom, \n (ii) a C 1-6  alkyl group optionally substituted by the same or different 1 to 5 substituents selected from the following group B, or \n (iii) a C 3-8  cycloalkyl group, or \n R a  and R b  optionally form, together with the nitrogen atom bonded thereto, a saturated monocyclic hetero ring optionally containing, besides carbon atom and one nitrogen atom, 1 to 5 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, and optionally substituted by the same or different 1 to 5 substituents selected from the following group B, \n \n (4) a C 1-6  alkyl group optionally substituted by the same or different 1 to 5 substituents selected from the following group A, or \n (5) a cyano group, or \n R 2  and R 3 , or R 4  and R 5  optionally form, together with the carbon atom bonded thereto, \n i) C 3-8  cycloalkane, or \n ii) a saturated monocyclic hetero ring containing, besides carbon atom, 1 to 6 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, \n wherein R 2 , R 3 , R 4  and R 5  are not hydrogen atoms at the same time, \n R 6  is \n (1) a C 1-6  alkyl group optionally substituted by the same or different 1 to 5 halogen atoms, \n (2) a C 1-6  alkoxy group, \n (3) a halogen atom, or \n (4) a C 3-8  cycloalkyl group, \n Y is \n a nitrogen atom, \n m is an integer of 1 to 5, and when m is an integer of 2 to 5, then each R 6  may be the same or different, and \n n is an integer of 1 to 3, \n and wherein group A is selected from \n (a) \u2014CO\u2014NR A1 R A2  \n wherein R A1  and R A2  are the same or different and each is\n (i) a hydrogen atom, \n (ii) a C 1-6  alkyl group optionally substituted by the same or different 1 to 5 substituents selected from the following group B, or \n (iii) a C 3-8  cycloalkyl group, or \n \n R A1  and R A2  optionally form, together with the nitrogen atom bonded thereto, a saturated monocyclic hetero ring optionally containing, besides carbon atom and one nitrogen atom, 1 to 3 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, and optionally substituted by the same or different 1 to 5 substituents selected from the following group B, \n \n (b) a hydroxyl group, \n (c) a C 1-6  alkoxy group, \n (d) a C 1-6  alkoxy-C 1-6  alkoxy group, \n (e) a cyano group, \n (f) \u2014NR A3 R A4  \n wherein R A3  and R A4  are the same or different and each is\n (i) a hydrogen atom, \n (ii) a C 1-6  alkyl group, \n (iii) a C 1-6  alkyl-carbonyl group, or \n (iv) a C 1-6  alkyl-sulfonyl group, or \n \n R A3  and R A4  optionally form, together with the nitrogen atom bonded thereto, a hetero ring optionally containing, besides carbon atom and one nitrogen atom, 1 to 5 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, and optionally substituted by 1 or 2 oxo groups, \n \n (g) a carboxyl group, \n (h) a C 1-6  alkyl-sulfonyl group, and \n (i) a C 1-6  alkyl-carbonyl group; \n and group B is selected from \n (a) a hydroxyl group, \n (b) a C 1-6  alkoxy group, \n (c) a C 1-6  alkoxy-C 1-6  alkyl group \n (d) a C 3-8  cycloalkyl group, and \n (e) an oxo group.

Metadata:
- Claim Count in Document: 99.0
- Percentile: 95.0
- Lexical Diversity: 1.65909
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13034866', '11767021', '12576605', '12837679', '11736064']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7938253462526744
- 35 USC 102 Novelty (BERT): 0.5752016845241049
- Combined Prediction Score: 0.7719629800798175
- Mean Citation Score: 390.11279
- Max Citation Score: 444.2332
- Similarity Product: 422.6765564255477

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test