PATENT CLAIM ANALYSIS

Application Number: 16376478
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["514", "291000"]

Abstract:
The present invention relates to a sterile pharmaceutical composition comprising tiotropium or a pharmaceutically acceptable salt thereof, for inhalation via nebulization to a subject (e.g. a human). The invention also relates to a process for preparing the pharmaceutical composition and its use in the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) in a subject.

Claim (Index 80):
A stable inhalation solution for the treatment of a respiratory disease, the inhalation solution being suitable for administration with a nebulizer, the inhalation solution comprising:\n (i) about 10 to about 80 micrograms of tiotropium bromide; (ii) water (iii) sodium chloride; and (iv) disodium EDTA, wherein\n the inhalation solution is free of preservative and has an osmolality of about 275 to about 325 mOsm/kg, \n the pH of the inhalation solution is between about 2.6 to about 3.0, \n the inhalation solution contains greater than 90% of the initial amount of tiotropium bromide after being stored for 2 years at 25\u00b0 C., \n the inhalation solution contains no more than 1% of 2-hydroxy-2,2-dithiophen-2-ylacetic acid after 1 month of storage at 40\u00b0 C. and 75% relative humidity, \n the inhalation solution is contained in a prefilled container, and \n the inhalation solution is prepared by (a) adding tiotropium bromide to a solution of sodium chloride and disodium EDTA, where the solution has a pH of 2.6 to 3.0, (b) filtering the solution from step (a), and (c) filling a container with the filtered solution.

Metadata:
- Claim Count in Document: 149.0
- Percentile: 100.0
- Lexical Diversity: 1.43478
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15663246', '15972738', '15157143', '15783146', '11506128']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8014869094970152
- 35 USC 102 Novelty (BERT): 0.5503728473938622
- Combined Prediction Score: 0.7763755032866999
- Mean Citation Score: 379.661482
- Max Citation Score: 460.86743
- Similarity Product: 277.3278899789983

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test