PATENT CLAIM ANALYSIS

Application Number: 15895883
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-02
Patent Classification: ["514", "639000"]

Abstract:
A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a ribonucleotide reductase allosteric modulator (RRAmod), the amount being effective to inhibit neoplastic cell growth.

Claim (Index 14):
The method of  claim 10 , the RRAmod comprising a small molecule having the formula: wherein each of R 1  to R 20 , R 46  to R 63  can be independently selected from the group consisting of hydrogen, C 1 -C 24  alkyl, C 2 -C 24  alkenyl, C 2 -C 24  alkynyl, C 3 -C 20  aryl, C 6 -C 24  alkaryl, C 6 -C 24  aralkyl, halo, silyl, hydroxyl, sulfhydryl, C 1 -C 24  alkoxy, C 2 -C 24  alkenyloxy, C 2 -C 24  alkynyloxy, C 5 -C 20  aryloxy, acyl (including C 2 -C 24  alkylcarbonyl (\u2014CO-alkyl) and C 6 -C 20  arylcarbonyl (\u2014CO-aryl)), acyloxy (\u2014O-acyl), C 2 -C 24  alkoxycarbonyl (\u2014(CO)\u2014O-alkyl), C 6 -C 20  aryloxycarbonyl (\u2014(CO)\u2014O-aryl), C 2 -C 24  alkylcarbonato (\u2014O\u2014(CO)\u2014O-alkyl), C 6 -C 20  arylcarbonato (\u2014O\u2014(CO)\u2014O-aryl), carboxy (\u2014COOH), carboxylato (\u2014COO \u2212 ), carbamoyl (\u2014(CO)\u2014NH 2 ), C 1 -C 24  alkyl-carbamoyl (\u2014(CO)\u2014NH(C 1 -C 24  alkyl)), arylcarbamoyl (\u2014(CO)\u2014NH-aryl), thiocarbamoyl (\u2014(CS)\u2014NH 2 ), carbamide (\u2014NH\u2014(CO)\u2014NH 2 ), cyano(\u2014CN), isocyano (\u2014N + C \u2212 ), cyanato (\u2014O\u2014CN), isocyanato (\u2014O\u2014N + \u2550C \u2212 ), isothiocyanato (\u2014S\u2014CN), azido (\u2014N\u2550N + \u2550N \u2212 ), formyl (\u2014(CO)\u2014H), thioformyl (\u2014(CS)\u2014H), amino (\u2014NH 2 ), C 1 -C 24  alkyl amino, C 5 -C 20  aryl amino, C 2 -C 24  alkylamido (\u2014NH\u2014(CO)-alkyl), C 6 -C 20  arylamido (\u2014NH\u2014(CO)-aryl), imino (\u2014CR\u2550NH where R is hydrogen, C 1 -C 24  alkyl, C 5 -C 20  aryl, C 6 -C 24  alkaryl, C 6 -C 24  aralkyl, etc.), alkylimino (\u2014CR\u2550N(alkyl), where R=hydrogen, alkyl, aryl, alkaryl, aralkyl, etc.), arylimino (\u2014CR\u2550N(aryl), where R=hydrogen, alkyl, aryl, alkaryl, etc.), nitro (\u2014NO 2 ), nitroso (\u2014NO), sulfo (\u2014SO 2 \u2014OH), sulfonato (\u2014SO 2 \u2014O \u2212 ), C 1 -C 24  alkylsulfanyl (\u2014S-alkyl; also termed \u201calkylthio\u201d), arylsulfanyl (\u2014S-aryl; also termed \u201carylthio\u201d), C 1 -C 24  alkylsulfinyl (\u2014(SO)-alkyl), C 5 -C 20  arylsulfinyl (\u2014(SO)-aryl), C 1 -C 24  alkylsulfonyl (\u2014SO 2 -alkyl), C 5 -C 20  arylsulfonyl (\u2014SO 2 -aryl), phosphono (\u2014P(O)(OH) 2 ), phosphonato (\u2014P(O)(O \u2212 ) 2 ), phosphinato (\u2014P(O)(O \u2212 )), phospho (\u2014PO 2 ), phosphino (\u2014PH 2 ), combinations thereof, and wherein adjacent R groups may be linked to form a cyclic or polycyclic ring, wherein the cyclic ring is aromatic, alicyclic, heteroaromatic, or heterocyclic; X 1  is a C 1 -C 24  alkyl, C 2 -C 24  alkenyl, C 2 -C 24  alkynyl; Y 1  is a C 1 -C 24  alkyl, C 2 -C 24  alkenyl, C 2 -C 24  alkynyl; R 45  is hydrogen, a C 1 -C 24  alkyl, C 2 -C 24  alkenyl, C 2 -C 24  alkynyl, an amino (\u2014NH 2 ), or \u2014(C 1 -C 24  alkyl)-amino, and combinations thereof; and a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 88.0
- Lexical Diversity: 1.35714
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14387151', '13840549', '14029066', '13879101', '11223433']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7536322199337863
- 35 USC 102 Novelty (BERT): 0.5638391937791163
- Combined Prediction Score: 0.7346529173183193
- Mean Citation Score: 276.552862
- Max Citation Score: 472.33466
- Similarity Product: 341.76268030272723

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test