PATENT CLAIM ANALYSIS

Application Number: 15981854
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["435", "006100"]

Abstract:
The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c).

Claim (Index 14):
A method for identifying molecules with desired characteristics comprising:\n a) Adding linker molecules L to at least 100 reaction wells; b) Contacting the linker molecules L of said reaction wells with a molecule fragment different from the molecule fragment added to the other wells, under conditions sufficient to allow the molecule fragment to attach to the linker molecules of the same well; c) Contacting the linker molecules L of said reaction wells with an oligonucleotide identifier different from the oligonucleotide identifier added to any of the other wells, under conditions sufficient to allow the oligonucleotide identifier to attach to the linker molecules of the same well; wherein steps b) and c) may be performed in any order to form bi-functional molecules comprising a molecule fragment, a linker molecule L, and an oligonucleotide identifier; d) Combining the resulting bifunctional molecules of steps a) to c) into an admixture, and aliquoting said admixture into at least 100 different reaction wells; e) Contacting the bi-functional molecules of each of said reaction wells with a molecule fragment different from the molecule fragment added to any of the other wells in this step e), under conditions sufficient to allow said molecule fragment to attach to said bi-functional molecules; f) Contacting the bi-functional molecules of each of said reaction wells with an oligonucleotide identifier different from the oligonucleotide identifier added to any of the other wells in this step f), under conditions sufficient to allow said oligonucleotide identifier to attach to said bi-functional molecules; wherein steps e) and f) may be performed in any order to form bi-functional molecules each comprising an encoded molecule comprising at least two molecule fragments, a linker molecule L, and at least two oligonucleotide identifiers; g) Combining the resulting bi-functional molecules of steps d) to f) into an admixture; wherein in step b) at least one reactive group of the linker molecule L reacts with a reactive group in the molecule fragment; wherein in step c) at least one reactive group of the linker molecule L reacts with a reactive group in the oligonucleotide identifier; wherein in step e) at least one reactive group of the molecule fragment reacts with a reactive group in a molecule fragment attached to Linker L, wherein in step f) at least one reactive group of the oligonucleotide identifier reacts with a reactive group in an oligonucleotide identifier attached to Linker L; wherein at least one of said encoded molecules comprise a tricyclic heterocycle, or at least two of said encoded molecules comprise a polycyclic heterocycle, of which one is a bridged polycyclic heterocycle, or at least one of said encoded molecules comprise a trifunctional aromatic heterocycle; h) Contacting the admixture of bifunctional molecules of step g) with target molecules, under conditions allowing the binding of some of the bifunctional molecules to said target molecules, under conditions where the target molecules are immobilized on a solid support, during or after the binding of some of the bifunctional molecules to said target molecules; i) Washing the solid support; j) Releasing the bifunctional molecules from the solid support; k) Contacting the released bifunctional molecules of step j) with target molecules, under conditions allowing the binding of some of the bifunctional molecules to said target molecules, under conditions where the target molecules are immobilized on a solid support, during or after the binding of some of the bifunctional molecules to said target molecules; l) Washing the solid support; m) Optionally releasing the bifunctional molecules from the solid support; n) Sequencing the oligonucleotide identifiers of the bifunctional molecules that were recovered in step k), l) or m) to identify the encoded molecules that bound the target molecules; o) Producing said encoded molecules in their free form by organic chemistry; and p) Analysing the characteristics of said encoded molecules in their free form.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 93.0
- Lexical Diversity: 2.46377
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14067789', '11719846', '14571941', '10175539', '12834072']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6353878733756136
- 35 USC 102 Novelty (BERT): 0.6237462055797924
- Combined Prediction Score: 0.6342237065960316
- Mean Citation Score: 422.12705000000005
- Max Citation Score: 652.50995
- Similarity Product: 521.8870117185621

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test