PATENT CLAIM ANALYSIS

Application Number: 16150916
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-01
Patent Classification: ["514", "405000"]

Abstract:
Methods and compositions for treating a subject hosting a non-ACTH-secreting pancreatic tumor are disclosed. The methods include administering to the subject a chemotherapeutic agent and a glucocorticoid receptor modulator (GRM), preferably a selective glucocorticoid receptor modulator (SGRM), to reduce the tumor load in the subject. The GRM may be a nonsteroidal GRM, and may be a nonsteroidal SGRM. The non-ACTH-secreting pancreatic tumor may be an exocrine pancreatic tumor. The nonsteroidal SGRM may be a nonsteroidal compound comprising: a fused azadecalin structure; a heteroaryl ketone fused azadecalin structure; or an octahydro fused azadecalin structure. Pharmaceutical compositions comprising a chemotherapeutic agent and a GRM are disclosed. The GRM in such pharmaceutical compositions may be a nonsteroidal GRM, and may be a SGRM, such as a nonsteroidal SGRM. The nonsteroidal SGRM may comprise: a fused azadecalin structure; a heteroaryl ketone fused azadecalin structure; or an octahydro fused azadecalin structure.

Claim (Index 1):
A method of treating a subject hosting a non-ACTH-secreting pancreatic tumor, the method comprising administering to the subject an effective amount of a chemotherapeutic agent and orally administering an effective amount of a nonsteroidal selective glucocorticoid receptor modulator to reduce the tumor load of the pancreatic tumor, wherein the nonsteroidal selective glucocorticoid receptor modulator is a compound comprising a fused azadecalin structure having the formula: wherein\n L 1  and L 2  are members independently selected from a bond and unsubstituted alkylene; \n R 1  is a member selected from unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted heterocycloalkyl, \u2014OR 1A , NRCR 1D , \u2014C(O)NR 1C R 1D , and \u2014C(O)OR 1A , wherein \n R 1A  is a member selected from hydrogen, unsubstituted alkyl and unsubstituted heteroalkyl, \n R 1C  and R 1D  are members independently selected from unsubstituted alkyl and unsubstituted heteroalkyl, \n wherein R 1C  and R 1D  are optionally joined to form an unsubstituted ring with the nitrogen to which they are attached, wherein said ring optionally comprises an additional ring nitrogen; \n R 2  has the formula: \n wherein R 2G  is a member selected from hydrogen, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, \u2014CN, and \u2014CF 3 ; J is phenyl; t is an integer from 0 to 5; X is \u2014S(O 2 )\u2014; and R 5  is phenyl optionally substituted with 1-5 R 5A  groups, wherein R 5A  is a member selected from hydrogen, halogen, \u2014OR 5A1 , S(O 2 )NR 5A2 R 5A3 , \u2014CN, and unsubstituted alkyl, wherein R 5A1  is a member selected from hydrogen and unsubstituted alkyl, and R 5A2  and R 5A3  are members independently selected from hydrogen and unsubstituted alkyl, or salts and isomers thereof.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 3.01786
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15697878', '15915477', '15942312', '15796443', '15236015']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7877159777549619
- 35 USC 102 Novelty (BERT): 0.7196495608671728
- Combined Prediction Score: 0.7809093360661831
- Mean Citation Score: 554.6482619999998
- Max Citation Score: 776.2292
- Similarity Product: 760.1215294965982

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test