PATENT CLAIM ANALYSIS

Application Number: 15990495
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-10
Patent Classification: ["514", "006200"]

Abstract:
An insulin analog with an improved in vitro effect compared with native insulin, a nucleic acid encoding the same, an expression vector including the nucleic acid, a transformant introduced with the expression vector, a method of producing the insulin analog from the transformant, a pharmaceutical composition for treating diabetes containing the insulin analog as an active ingredient, and a method for treating diabetes using the insulin analog or the pharmaceutical composition.

Claim (Index 1):
An insulin analog peptide comprising an A-chain of SEQ ID NO: 3 indicated in the following General Formula 1 and a B-chain of SEQ ID NO: 4 indicated in the following General Formula 2: (General\u2003Formula\u20031) (SEQ\u2003ID\u2003NO:\u20033) Xaa1 -Ile-Val-Glu- Xaa2 -Cys-Cys-Thr-Ser-Ile-Cys-   Xaa3 -Leu- Xaa4 -Gln- Xaa5 -Glu-Asn- Xaa6 -Cys- Xaa7 wherein Xaa1 is alanine, glycine, glutamine, histidine, glutamic acid, or asparagine; Xaa2 is alanine, glutamic acid, glutamine, histidine, or asparagine; Xaa3 is alanine, serine, glutamine, glutamic acid, histidine, or asparagine; Xaa4 is histidine, lysine, or aspartic acid; Xaa5 is alanine, leucine, tyrosine, histidine, glutamic acid, or asparagine; Xaa6 is alanine, tyrosine, serine, glutamic acid, histidine, or asparagine; and Xaa7 is asparagine, glycine, histidine, or alanine; and (General\u2003Formula\u20032) (SEQ\u2003ID\u2003NO:\u20034) Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-   Glu-Ala-Leu- Xaa8 -Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-   Xaa9 -Tyr- Xaa10 - Xaa11 -Lys-Thr wherein Xaa8 is tyrosine, glutamic acid, or aspartic acid, or is absent; Xaa9 is phenylalanine, or is absent; Xaa10 is threonine, or is absent; and Xaa11 is proline, glutamic acid, or aspartic acid, or is absent.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 93.0
- Lexical Diversity: 1.95
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15250459', '15113027', '15513748', '15846485', '13130976']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7865993704260508
- 35 USC 102 Novelty (BERT): 0.6469934665232319
- Combined Prediction Score: 0.7726387800357688
- Mean Citation Score: 452.294464
- Max Citation Score: 639.04944
- Similarity Product: 589.6710603246116

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test