PATENT CLAIM ANALYSIS

Application Number: 15890181
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["536", "017900"]

Abstract:
The invention comprises a new process for the preparation of GalNAc derivatives of the formula I wherein n is an integer between 0 and 10 and its salts, corresponding enantiomers and/or optical isomers thereof. The GalNAc acid derivative of formula I can be used for the preparation of therapeutically valuable GalNAc oligonucleotide conjugates.

Claim (Index 9):
Process of  claim 1  wherein the process for producing the triamine of formula II comprises the steps\n a1) transforming the carboxylic acid of formula X \n wherein R 3\u2032  and R 4  are different and independent of each other are amino protecting groups into an ester of formula XI wherein R 1  is an ester protecting group and R 3\u2032  and R 4  are as above; b1) removing the amino protecting group R 4  and subsequent forming an amine salt of formula XII wherein R 1  and R 3\u2032  are as above and X \u2212  is an acid anion; c1) coupling the amine salt of formula XII with a hexanoic acid derivative of formula XIII wherein R 3\u2033  and R 3\u2032\u2033  are amino protecting groups to form the protected triamine of formula XIV wherein R 3\u2032 , R 3\u2032 , R 3\u2032\u2033  and R 1  are as above; d1) converting the protected triamine of formula XIV with an acid into the triamine salt of formula II.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 88.0
- Lexical Diversity: 1.33333
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['10542176', '15534676', '13810062', '14354478', '12341281']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6310890047039978
- 35 USC 102 Novelty (BERT): 0.5036322332419196
- Combined Prediction Score: 0.61834332755779
- Mean Citation Score: 249.75634800000003
- Max Citation Score: 267.39838
- Similarity Product: 186.4799893184161

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test