PATENT CLAIM ANALYSIS

Application Number: 16454319
Application Type: Utility
Filing Date: 2019-06
Publication Date: 2019-10
Patent Classification: ["514", "226500"]

Abstract:
Disclosed herein are compositions comprising an NSAID such as meloxicam and/or rizatriptan in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a T max  of meloxicam of 3 hours or less.

Claim (Index 1):
A method of treating migraine comprising: orally administering a solid dosage form once daily to a human being suffering from a migraine, wherein the solid dosage form comprises: 1) a complex of meloxicam and a sulfobutyl ether \u03b2-cyclodextrin (SBE\u03b2CD), and 2) a bicarbonate, wherein orally administering the solid dosage form to the human being results in a T max  of meloxicam that is shorter than a T max  of a reference solid dosage form that: 1) contains the same amount of meloxicam, 2) does not contain an SBE\u03b2CD, and 3) does not contain a bicarbonate, wherein the solid dosage form has been shown to have a median T max  of meloxicam that is less than 2 hours in human subjects, wherein the human being is selected for having a history of inadequate response to prior migraine treatments, and wherein the human being is free of migraine pain two hours after the dosage form is orally administered to the human being.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 100.0
- Lexical Diversity: 2.09722
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16248449', '16440695', '16247406', '15986215', '15902770']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7864705410628504
- 35 USC 102 Novelty (BERT): 0.5804443165191466
- Combined Prediction Score: 0.76586791860848
- Mean Citation Score: 444.79049
- Max Citation Score: 457.075
- Similarity Product: 451.93913636058574

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test