PATENT CLAIM ANALYSIS

Application Number: 15958295
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-08
Patent Classification: ["424", "246100"]

Abstract:
The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.

Claim (Index 1):
A pharmaceutical composition comprising (i) a pharmaceutically acceptable excipient and (ii) a branched chimeric compound of formula (I):\n [D-L 1 -L 2 -(PEG)-L 3 ] x -F\u2003\u2003(I) wherein: D is a linear chimeric compound; L 1  is a first linker comprising an alkylthio group; L 2  is a second linker comprising a succinimide group; L 3  is a third linker comprising an amide group; PEG is of the formula \u2014(OCH 2 CH 2 ) n \u2014, where n is an integer from 2 to 80; x is an integer from 3 to 300; and F is a branched copolymer of sucrose and epichlorohydrin having a molecular weight of about 100,000 to about 700,000 daltons and is connected to L 3  via an ether group; and wherein the linear chimeric compound of D comprises three nucleic acid moieties and two hexaethylene glycol (HEG) spacers as 5\u2032-TCGGCGC-3\u2032-HEG-5\u2032-AACGTTC-3\u2032-HEG-5\u2032-TCGGCGC-3\u2032 (SEQ ID NO:2), wherein the linear chimeric compound contains less than 50 nucleotides, and wherein one or more linkages between the nucleotides, between the nucleotides and the HEG spacers and between the 3\u2032-terminal nucleotide and L 1  are phosphorothioate ester linkages.

Metadata:
- Claim Count in Document: 104.0
- Percentile: 91.0
- Lexical Diversity: 1.51515
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15004860', '15958292', '13349515', '11590150', '14030975']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7330999248491119
- 35 USC 102 Novelty (BERT): 0.6496868200457288
- Combined Prediction Score: 0.7247586143687735
- Mean Citation Score: 445.214108
- Max Citation Score: 722.6764
- Similarity Product: 563.7653645394803

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test