PATENT CLAIM ANALYSIS

Application Number: 15746357
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "401000"]

Abstract:
A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.

Claim (Index 68):
The composition according to  claim 67 , wherein the molecule presenting anticancerous properties is chosen among the following list: doxorubicin, paclitaxel, docetaxel, any mitotic inhibitor, cisplatin, 5-FU, temozolomide, or any other.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 86.0
- Lexical Diversity: 2.09677
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15746298', '15798287', '12909572', '14113371', '15304127']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7221964544127873
- 35 USC 102 Novelty (BERT): 0.5664502339112847
- Combined Prediction Score: 0.7066218323626371
- Mean Citation Score: 348.739548
- Max Citation Score: 512.3136
- Similarity Product: 292.2669166030884

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test