PATENT CLAIM ANALYSIS

Application Number: 16145345
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["546", "117000"]

Abstract:
The present invention provides compounds of Formula (I): wherein A, X and Y are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

Claim (Index 5):
A compound according to  claim 4 or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein: Y is independently selected from: CH 2 , CHR 1 , \u2014CH 2 CH 2 \u2014, \u2014CH(C 1-4  alkyl)CH 2 \u2014, \u2014CH 2 CH(C 1-4  alkyl)-, \u2014(CH 2 ) 1-3 O(CH 2 ) 0-1 \u2014, \u2014CH 2 CH 2 NH(CH 2 ) 1-3 \u2014, \u2014CH 2 CH 2 N(C 1-4  alkyl)CH 2 \u2014, \u2014CH 2 CH 2 NHCHBn-, \u2014CH 2 CH 2 NHCH 2 CH(C 1-4  alkyl)-, \u2014CH 2 CH 2 NHCH(C 1-4  alkyl)CH 2 \u2014, \u2014CH 2 CH 2 NHCH 2 C(OH)(C 1-4  alkyl)-, and \u2014(CH 2 ) 1-2 CONH\u2014; R 1  is independently selected from: \u2014(C 1-4  alkyl substituted with 0-1 R 18 ), C 1-4  haloalkyl, COPh, CH(OH)Ph, CO 2 (C 1-4  alkyl), and CONHBn; R 2  is independently selected from: halogen, CN, \u2014CH 2 CN, CH 2 OH, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, \u2014CH(NH 2 )CF 3 , \u2014CH 2 NHCF 3 , CO 2 (C 1-4  alkyl), SO 2 (C 1-4  alkyl), SO 2 Bn, SO 2 NH 2 , SO 2 NH(C 1-4  alkyl), \u2014CH 2 SO 2 Ph, NH 2 , \u2014CH 2 N(C 1-4  alkyl) 2 , \u2014O(CH 2 ) 3 N(C 1-4  alkyl) 2 , CONH 2 , \u2014CONHCH 2 CH 2 N(C 1-4  alkyl) 2 , CONH(1-C 1-4  alkyl-cyclopropyl), C 3-6  cycloalkyl substituted with 0-1 CN, \u2014O\u2014C 3-6  cycloalkyl, phenoxy, benzoxy, \u2014(CH 2 ) 0-1 -(phenyl substituted with 0-2 R 11  and 0-1 R 12 ), pyrrolidinyl, pyrrolidinylmethyl, pyrazolyl, imidazolyl, oxadiazolyl, triazolyl, 1-C 1-4  alkyl-3-C 1-4  haloalkyl-pyrazo-5-yl, morpholinylmethyl, pyridyl, \u2014O-pyridyl, 2-CN-pyrid-4-yl, 2-CONH 2 -pyrid-4-yl, 4-(pyrrolidinyl)-pyrid-3-yl, 4-(piperazinyl)-pyrid-3-yl, pyrimidinyl, R 3  is, at each occurrence, independently selected from: halogen, CN, C 1-4  alkyl, C 1-4  alkoxy, and C 1-4  haloalkyl; alternatively, R 2  and R 3 , together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic or heterocyclic ring comprising carbon atoms and 0-3 heteroatoms selected from N, NR a , O, and S(O) p ; wherein said heterocycle is substituted with 0-2 R 19 ; R 18  is independently selected from: OH, CN, N(C 1-4  alkyl) 2 , NHBn, imidazolyl and morpholinyl; R 19  is independently selected from: halogen and CO 2 (C 1-4  alkyl); and R a  is, at each occurrence, independently selected from: H, C 1-4  alkyl, \u2014(CH 2 ) n \u2014C 3-6  cycloalkyl, \u2014(CH 2 ) n -(phenyl substituted with 0-1 R c ), (pyridyl substituted with 0-1 R c ), pyrazinyl, pyridazinyl, pyrimidinyl, and

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.33333
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15756373', '15756367', '15756378', '16099010', '16067619']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8044348431042947
- 35 USC 102 Novelty (BERT): 0.584995751661682
- Combined Prediction Score: 0.7824909339600334
- Mean Citation Score: 461.02643599999993
- Max Citation Score: 519.0335
- Similarity Product: 412.28833541065455

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test