PATENT CLAIM ANALYSIS

Application Number: 15918605
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["514", "04400A"]

Abstract:
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications.

Claim (Index 56):
A double-stranded ribonucleic acid (dsRNA) comprising a sense strand and an antisense strand, wherein the sense and/or antisense strand comprises at least 12 contiguous nucleotides of a sequence selected from the sequences within Tables 2, 3, 4, 5, 6, 7, 8, 9, 13, 14, 16, 17, 18, 19, 21, 22, 25, 26, and 27, wherein the dsRNA is an sd-rxRNA, wherein the antisense strand is 16-23 nucleotides long and the sense strand is 8-15 nucleotides long, wherein the sd-rxRNA includes a double-stranded region and a single-stranded region, wherein the double-stranded region is from 8-15 nucleotides long, wherein the single-stranded region is at the 3\u2032 end of the antisense strand and is 4-12 nucleotides long, wherein the single-stranded region contains 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 phosphorothioate modifications, and wherein at least 40% of the nucleotides of the double-stranded nucleic acid molecule are modified.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 90.0
- Lexical Diversity: 1.125
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13636755', '15099481', '13636748', '14728653', '14729006']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8928340440885361
- 35 USC 102 Novelty (BERT): 0.7675114002562147
- Combined Prediction Score: 0.8803017797053039
- Mean Citation Score: 845.7035699999999
- Max Citation Score: 1097.3495
- Similarity Product: 862.6927322303354

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test