PATENT CLAIM ANALYSIS

Application Number: 16153424
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-06
Patent Classification: ["514", "044000"]

Abstract:
The invention related to improved RNAi constructs and uses thereof. The construct has a double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and preferable blunt-ended. The construct has selective minimal modifications to confer an optimal balance of biological activity, toxicity, stability, and target gene specificity. For example, the sense strand may be modified (e.g., one or both ends of the sense strand it/are modified by four 2′—O-mehtyl groups), such that the construct is not cleaved by Dicer or other RNAse III, and the entire length of the antisense strand is loaded into RISC. In addition, the antisense strand may also be modified by 2′—O-methyl group at the 2nd 5′-end nucleotide to greatly reduce off-target silencing. The constructs of the invention largely avoids the interferon response and sequence-independent apoptosis in mammalian cells, exhibits better serum stability, and enhance target specificity.

Claim (Index 64):
The method of  claim 51 , wherein the 2\u2032-modified ribose sugars are 2\u2032\u2014O-alkyl nucleotides, 2\u2032-deoxy-2\u2032-fluoro nucleotides, 2\u2032-deoxy nucleotides, 2\u2032-H (deoxyribonucleotides), or a combination thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.61765
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12867181', '13491937', '14537578', '14463427', '13749110']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8212401103021657
- 35 USC 102 Novelty (BERT): 0.6291234847111937
- Combined Prediction Score: 0.8020284477430685
- Mean Citation Score: 463.96599
- Max Citation Score: 638.98047
- Similarity Product: 581.4797474401046

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test