PATENT CLAIM ANALYSIS

Application Number: 16043641
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["424", "452000"]

Abstract:
Provided herein are methods of treating multiple sclerosis with a fumarate, wherein the fumarate is a dialkyl fumarate, a monoalkyl fumarate, a combination of a dialkyl fumarate and a monoalkyl fumarate, a prodrug of monoalkyl fumarate, a deuterated form of any of the foregoing, or a pharmaceutically acceptable salt, clathrate, solvate, tautomer, or stereoisomer of any of the foregoing, or a combination of any of the foregoing. The methods provided herein improve the safety of treatment by informing and monitoring patients undergoing treatment regarding progressive multifocal leukoencephalopathy, and/or by monitoring lymphocyte count.

Claim (Index 328):
A method of treating a patient with multiple sclerosis, comprising the steps of:\n (a) administering a pharmaceutical composition comprising a fumarate to the patient; wherein the fumarate is dimethyl fumarate, monomethyl fumarate, a combination of dimethyl fumarate and monomethyl fumarate, or a pharmaceutically acceptable salt, clathrate, solvate, tautomer, or stereoisomer of any of the foregoing; with the proviso that ethyl hydrogen fumarate calcium salt, ethyl hydrogen fumarate magnesium salt, ethyl hydrogen fumarate zinc salt, and ethyl hydrogen fumarate copper salt are not present in the pharmaceutical composition; (b) obtaining a complete blood count including lymphocyte count after 6 months of repeated administering of said pharmaceutical composition to said patient, and every 6 to 12 months thereafter; and (c) interrupting administering of said pharmaceutical composition to said patient when the patient has a lymphocyte count less than 0.5\u00d710 9 /L persisting for more than six months.

Metadata:
- Claim Count in Document: 255.0
- Percentile: 95.0
- Lexical Diversity: 2.12
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15125612', '15386175', '15248506', '15582913', '15249820']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6823361562609352
- 35 USC 102 Novelty (BERT): 0.4952646246515182
- Combined Prediction Score: 0.6636290030999935
- Mean Citation Score: 216.669098
- Max Citation Score: 243.98125
- Similarity Product: 182.5723366539925

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test