PATENT CLAIM ANALYSIS

Application Number: 16153178
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["540", "095000"]

Abstract:
Reactions that directly install nitrogen into C—H bonds of complex molecules are significant because of their potential to change the chemical and biological properties of a given compound. Selective intramolecular C—H amination reactions that achieve high levels of reactivity, while maintaining excellent site-selectivity and functional-group tolerance is a challenging problem. Herein is reported a manganese perchlorophthalocyanine catalyst [Mn III (ClPc)] for intermolecular benzylic C—H amination of bioactive molecules and natural products that proceeds with unprecedented levels of reactivity and site-selectivity. In the presence of Brønsted or Lewis acid, the [Mn III (ClPc)]-catalyzed C—H amination demonstrates unique tolerance for tertiary amine, pyridine and benzimidazole functionalities. Mechanistic studies indicate that C—H amination proceeds through an electrophilic metallonitrene intermediate via a stepwise pathway where C—H cleavage is the rate-determining step of the reaction. Collectively these mechanistic features contrast previous base-metal catalyzed C—H aminations.

Claim (Index 11):
A method for forming a C\u2014N bond comprising contacting an organic substrate, a nitrogen-containing oxidant, and a compound of  claim 1 , in a solvent to form a mixture, wherein a C\u2014H moiety of the organic substrate is aminated, thereby forming a C\u2014N bond.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 97.0
- Lexical Diversity: 1.50476
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15076434', '15604377', '14916966', '15109396', '10527899']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6853645050128926
- 35 USC 102 Novelty (BERT): 0.516029096826037
- Combined Prediction Score: 0.6684309641942071
- Mean Citation Score: 247.061686
- Max Citation Score: 285.6052200000001
- Similarity Product: 203.318899169823

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test