PATENT CLAIM ANALYSIS

Application Number: 16274132
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["424", "181100"]

Abstract:
Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein.

Claim (Index 1):
A compound represented by the structure of Formula (IIB): or a pharmaceutically acceptable salt thereof, wherein:\n L 10  is selected from \u2014C(O)\u2014, and \u2014C(O)N(R 10 )\u2014*, wherein * represents where L 10  is bound to R 5 \u2014; \n L 2  is selected from \u2014C(O)\u2014 and \u2014C(O)N(R 10 )\u2014; \n R 1  and R 2  are independently selected from hydrogen; and C 1-10  alkyl, C 2-10  alkenyl, and C 2-10  alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), and \u2014CN; \n R 4  is selected from: \n \u2014OR 10 , \u2014N(R 10 ) 2 , \u2014C(O)N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014S(O)R 10 , and \u2014S(O) 2 R 10 ; and \n C 1-10  alkyl, C 2-10  alkenyl, C 2-10  alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 )C(O)R 10 , \u2014N(R 10 )C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), \u2014CN, C 3-12  carbocycle, and 3- to 12-membered heterocycle; and \n C 3-12  carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 )C(O)R 10 , \u2014N(R 10 )C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), \u2014CN, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl; \n R 5  is selected from unsaturated C 4-8  carbocycle; bicyclic carbocycle; and fused 5-5, fused 5-6, and fused 6-6 bicyclic heterocycle, wherein R 5  is optionally substituted and wherein substituents are independently selected at each occurrence from: \n halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 )C(O)R 10 , \u2014N(R 10 )C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), and \u2014CN; and \n C 1-10  alkyl, C 2-10  alkenyl, C 2-10  alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 )C(O)R 10 , \u2014N(R 10 )C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), \u2014CN, C 3-12  carbocycle, and 3- to 12-membered heterocycle; and \n C 3-12  carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OR 10 , \u2014SR 10 , \u2014C(O)N(R 10 ) 2 , \u2014N(R 10 )C(O)R 10 , \u2014N(R 10 )C(O)N(R 10 ) 2 , \u2014N(R 10 ) 2 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), \u2014CN, C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl; \n R 10  is independently selected at each occurrence from: \n hydrogen, \u2014NH 2 , \u2014C(O)OCH 2 C 6 H 5 ; and \n C 1-10  alkyl, C 2-10  alkenyl, C 2-10  alkynyl, C 3-12  carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, \u2014OH, \u2014CN, \u2014NO 2 , \u2014NH 2 , \u2550O, \u2550S, \u2014C(O)OCH 2 C 6 H 5 , \u2014NHC(O)OCH 2 C 6 H 5 , C 1-10  alkyl, \u2014C 1-10  haloalkyl, \u2014O\u2014C 1-10  alkyl, C 2-10  alkenyl, C 2-10  alkynyl, C 3-12  carbocycle, 3- to 12-membered heterocycle, and haloalkyl; \n R 20 , R 21 , R 22 , and R 23  are independently selected from hydrogen, halogen, \u2014OR 10 , \u2014SR 10 , \u2014N(R 10 ) 2 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), \u2014CN, C 1-10  alkyl, C 2-10  alkenyl, and C 2-10  alkynyl; and \n R 24  and R 25  are independently selected from hydrogen, halogen, \u2014OR 10 , \u2014SR 10 , \u2014N(R 10 ) 2 , \u2014S(O)R 10 , \u2014S(O) 2 R 10 , \u2014C(O)R 10 , \u2014C(O)OR 10 , \u2014OC(O)R 10 , \u2014NO 2 , \u2550O, \u2550S, \u2550N(R 10 ), \u2014CN, C 1-10  alkyl, C 2-10  alkenyl, and C 2-10  alkynyl; or R 24  and R 25  taken together form an optionally substituted saturated C 3-7  carbocycle.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 99.0
- Lexical Diversity: 1.5
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16274130', '15774262', '15973506', '15509989', '10493279']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8146789289347729
- 35 USC 102 Novelty (BERT): 0.6091232614398788
- Combined Prediction Score: 0.7941233621852836
- Mean Citation Score: 477.541558
- Max Citation Score: 547.21844
- Similarity Product: 505.52701148198855

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test