PATENT CLAIM ANALYSIS

Application Number: 15766395
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "211150"]

Abstract:
The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by  Mycobacterium tuberculosis  comprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

Claim (Index 1):
A compound of formula I or a pharmaceutically acceptable salt thereof, wherein: R 1  is \u2014CH 2 N(R 2 ) 2 , \u2014CH 2 NR 2 COR 3 , \u2014CH 2 NR 2 COOR 3 , \u2014CH 2 NR 2 CON(R 2 ) 2 , \u2014CH 2 NR 2 CONR 2 N(R 2 ) 2 , \u2014CH 2 NR 2 SO 2 R 3 , \u2014CON(R 2 ) 2 , \u2014C\u2550NOR 3 , \u2014CH 2 OR 4 , \u2014CH 2 NR 2 R 4 , or \u2014CH 2 R 6 . each occurrence of R 2  is independently selected from H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 3 -C 6  cycloalkyl, wherein said C 1 -C 6  alkyl, said C 2 -C 6  alkenyl, and said C 3 -C 6  cycloalkyl can be optionally substituted with up to four substituents, which are independently selected from halogen, \u2014OCH 3 , \u2014OH, \u2014NH 2 , \u2014NHCH 3 , and \u2014N(CH 3 ) 2 ; R 3  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 3 -C 6  cycloalkyl, wherein said C 1 -C 6  alkyl, said C 2 -C 6  alkenyl and said C 3 -C 6  cycloalkyl can be optionally substituted with up to four substituents, which are independently selected from halogen, \u2014OCH 3 , \u2014OH, \u2014NH 2 , \u2014NHCH 3 , and \u2014N(CH 3 ) 2 ; R 4  is a 5- or 6-membered heterocycle, which is optionally substituted with R 5 ; R 5  is selected from H, halogen, C 1 -C 6  alkyl, C 3 -C 6  alkenyl, and C 3 -C 6  cycloalkyl, wherein said C 1 -C 6  alkyl, said C 3 -C 6  alkenyl, and said C 3 -C 6  cycloalkyl can be optionally substituted with up to four substitutents, which are independently selected from halogen, \u2014OCH 3 , \u2014OH, \u2014NH 2 , \u2014NHCH 3 , and \u2014N(CH 3 ) 2 ; R 6  is H, C 1 -C 6  alkyl, or a 5-membered heterocycle, wherein said 5-membered heterocycle is optionally substituted with up to two R 7 ; each occurrence of R 7  is H, halogen, oxo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, or C 3 -C 6  cycloalkyl, wherein said C 1 -C 6  alkyl and said C 3 -C 6  cycloalkyl can be optionally substituted with from one to four substituents which are independently selected from halogen, \u2014OCH 3 , \u2014OH, \u2014NH 2 , \u2014NHCH 3 , and \u2014N(CH 3 ) 2 ; E is a 6-membered aryl or a 5- or 6-membered heteroaryl containing from one to three heteroatoms independently selected from S, O, and N, wherein said aryl and said heteroaryl are optionally substituted with up to four substituents, which are independently selected from halogen, \u2014CN, \u2014CF 3 , \u2014CHF 2 , \u2014CH 2 NH 2 , \u2014CH 2 NHCOCH 3 , \u2014OCF 3 , \u2014OCHF 2 , \u2014OH, \u2014O\u2014(C 1 -C 6 )alkyl, C 1 -C 6  alkyl, and C 3 -C 6  cycloalkyl; A is a heterocycle optionally substituted with up to four R 8 , or an aryl optionally substituted with up to four R 8 ; each occurrence of R 8  is independently selected from H, halogen, C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  heterocycloalkyl, benzyl, \u2014OCF 3 , \u2014OCHF 2 , \u2014OR 3 , \u2550O, \u2014CN, \u2014NO 2 , \u2014SR 3 , \u2014SF 5 , \u2014SCF 3 , \u2014SOR 3 , \u2014SO 2 R 3 , \u2014S(\u2550O)(\u2550NH)R 2 , \u2014N(R 2 ) 2 , \u2014NR 2 COR 3 , \u2014SO 2 N(R 2 ) 2 , \u2014NR 2 SO 2 R 3 , \u2014COOH, \u2014COOR 3 , \u2014CON(R 2 ) 2 , and \u2014C(R 9 ) 2 N(R 2 ) 2 , wherein said C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  heterocycloalkyl, and benzyl are optionally substituted with up to four F, \u2014OCH 3 , \u2014OH, \u2550O, NH 2 , NHCH 3 , and N(CH 3 ) 2 ; and each occurrence of R 9  is independently selected from H, C 1 -C 6  alkyl, and C 3 -C 6  cycloalkyl.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 91.0
- Lexical Diversity: 1.5873
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15517570', '15910571', '15309533', '15738503', '11655840']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8143341141286227
- 35 USC 102 Novelty (BERT): 0.5246450711752616
- Combined Prediction Score: 0.7853652098332866
- Mean Citation Score: 330.851608
- Max Citation Score: 338.07108
- Similarity Product: 259.00237659366843

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test