PATENT CLAIM ANALYSIS

Application Number: 16099112
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["424", "400000"]

Abstract:
The invention provides an agent delivery system comprising an agent preparation encapsulated within a membrane composition. The invention further provides a membrane composition comprising a ganglioside and lipid for encapsulating agents, and processes for preparing the membrane compositions. The invention further provides agent preparations encapsulated within the membrane compositions, including a plurality of individual particles wherein each particle contains agent preparation individually encapsulated within membrane composition. The invention also provides processes for preparing encapsulated agent preparations or individual particles of encapsulated agent preparations. The agents may be biologically active including hydrophilic, hydrophobic, small molecule or large molecule therapeutic agents. The invention further provides pharmaceutical compositions comprising encapsulated agent preparations or individual particles of encapsulated agent preparations. The invention further provides methods for delivery of the encapsulated agent preparations or individual particles of encapsulated agent preparations to a subject, including oral delivery of large molecule therapeutic agents to the lymphatic system, blood circulatory system, and/or targeted delivery to cells, tissues or organs.

Claim (Index 19):
The agent preparation encapsulated within the membrane composition of  claim 18 , wherein the membrane composition encapsulates the agent preparation with a first bilayer comprising a lipid and ganglioside, the ganglioside having a lipophilic domain and a hydrophilic domain, wherein the hydrophilic domain comprises (i) a mono-, di-, tri-, or tetra-saccharide residue, and (ii) one to four sialic acid residues linked to the saccharide residue, the bilayer having an outer surface, wherein at least a portion of the hydrophilic domain of the ganglioside is present on the outer surface.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 98.0
- Lexical Diversity: 2.79365
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15986186', '12428388', '12428395', '14366839', '15603992']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.723386048021112
- 35 USC 102 Novelty (BERT): 0.4945277324786693
- Combined Prediction Score: 0.7005002164668677
- Mean Citation Score: 212.53765
- Max Citation Score: 216.7301
- Similarity Product: 143.80568140202757

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test