PATENT CLAIM ANALYSIS

Application Number: 16336363
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "234200"]

Abstract:
The present invention relates to a class of cyano-substituted-heterocycles of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction. (I)

Claim (Index 2):
A compound for use, according to  claim 1 , wherein:\n X is selected from O, N(R h ), and C(R i )(R j ); R a  is selected from hydrogen, fluoro, C 1 -C 3  alkyl, and C 1 -C 3  alkoxy; or R a  is linked to R b  or R i  to form a C 3 -C 4  cycloalkyl ring; R b , R c , R d  and R e , are each independently selected from hydrogen and C 1 -C 3  alkyl; or form one or more spirocyclic groups where R b  is linked to R c  or R d  is linked to R e , or R b  is linked to R a  to form a C 3 -C 4  cycloalkyl ring; R f  and R g , are each independently selected from hydrogen, fluoro, cyano, C 1 -C 3  alkyl, and C 1 -C 3  alkoxy; or form a spirocyclic group where R f  is linked to R g , or R g  is linked to R i  to form a C 3 -C 4  cycloalkyl ring; when X is O or N(R h ), none of R a , R f  and R, are fluoro or C 1 -C 3  alkoxy; R h  is selected from hydrogen, C 1 -C 3  alkyl, C(O)C 1 -C 3  alkyl, and S(O) 2 C 1 -C 3  alkyl; R i  and R j  are each independently selected from hydrogen, fluoro, cyano, C 1 -C 3  alkyl, and C 1 -C 3  alkoxy; or form a spirocyclic group where R i  is linked to R j , or R i  is linked to R a  or R g  to form a C 3 -C 4  cycloalkyl ring; ring A is a 5 to 10-membered monocyclic or bicyclic, heteroaryl or heterocyclyl ring, which is unsubstituted, or substituted with 1 to 6 Q 1 (R 1 ) n  groups, which may be the same or different; n is 0 or 1; Q 1  is selected from Q 1a  and Q 1b ; Q 1a  is selected from oxo, halo, cyano, nitro, hydroxyl, SR 4 , NR 2 R 3 , CONR 2 R 3 , C 0 -C 3 -alkylene-NR 4 COR 5 , NR 4 CONR 5 R 6 , COR 4 , C(O)OR 4 , SO 2 R 4 , SO 2 NR 4 R 5 , NR 4 SO 2 R 5 , NR 4 SO 2 NR 5 R 6 , NR 4 C(O)OR 5 , C 1 -C 6  alkyl, C 1 -C 6  alkoxy, and C 2 -C 6  alkenyl; Q 1b  is selected from a covalent bond, an oxygen atom, a sulfur atom, OR 7 , SO, SO 2 , CO, C(O)O, C 0 -C 3 -alkylene-C(O)NR 4 \u2014C 0 -C 3  alkylene, C 0 -C 3 -alkylene-NR 4 \u2014C 0 -C 3  alkylene, C 0 -C 3  alkylene-NR 4 C(O)\u2014C 0 -C 3  alkylene, NR 4 CONR 5 , SO 2 NR 4 , NR 4 SO 2 , NR 4 SO 2 NR 5 , NR 4 C(O)O, NR 4 C(O)OR 7 , C 1 -C 6  alkylene, and C 2 -C 6  alkenylene; R 1  is a 3 to 10-membered monocyclic or bicyclic, heterocyclyl, heteroaryl, cycloalkyl, or aryl ring; R 2 , R 3 , R 4 , R 5  and R 6 , are each independently selected from hydrogen and C 1 -C 6  alkyl; R 7  is C 1 -C 6  alkylene; R 1  is unsubstituted or substituted with 1 to 6 substituents, each independently selected from halo, cyano, oxo, nitro, hydroxyl, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, R 11 , and O\u2014R 11 ; and R 11  is a 5 to 6-membered aryl or heteroaryl ring, which may be unsubstituted or substituted with 1 to 5 substituents each independently selected from halo, cyano, oxo, nitro, amino, amido, hydroxyl, C 1 -C 6  alkyl, and C 1 -C 6  alkoxy, wherein the alkyl and alkoxy may be optionally substituted with halo.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 99.0
- Lexical Diversity: 1.32558
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16070936', '16080506', '15738900', '15894025', '16078518']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.844128406479696
- 35 USC 102 Novelty (BERT): 0.5591044725189465
- Combined Prediction Score: 0.815626013083621
- Mean Citation Score: 433.761262
- Max Citation Score: 448.00748
- Similarity Product: 348.2629710228061

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test