PATENT CLAIM ANALYSIS

Application Number: 15762828
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "620000"]

Abstract:
The present disclosure relates to a pharmaceutical composition for inducing an exercise mimetic effect, which contains an α 1 -adrenergic receptor agonist as an active ingredient, and a method for screening a drug for inducing an exercise mimetic effect using the α 1 -adrenergic receptor agonist. The α 1 -adrenergic receptor agonist of the present disclosure increases the expression of p-AMPK, PPARδ and PGC-1α, which play key roles in maintaining and regulating energy metabolic activity in vivo, thereby increasing glucose uptake into skeletal muscle cells, suppressing adipocyte differentiation and lipid accumulation, reducing abdominal fat and body weight as well as regulating mitochondrial metabolic disorders and suppressing inflammatory responses. Accordingly, the α 1 -adrenergic receptor agonist can be usefully used to prevent and treat diseases requiring AMPK activation (metabolic diseases, cardiovascular diseases, inflammatory disease, etc.).

Claim (Index 9):
The screening method according to  claim 7 , wherein, in the step (b), the expression is measured by western blotting, antigen immunoprecipitation, ELISA, mass spectrometry, RT-PCR, competitive RT-PCR, real-time RT-PCR, RPA (RNase protection assay) or northern blotting.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 90.0
- Lexical Diversity: 1.73563
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12810123', '14992969', '12994590', '15284267', '14432028']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.738614678719224
- 35 USC 102 Novelty (BERT): 0.5302835974103636
- Combined Prediction Score: 0.717781570588338
- Mean Citation Score: 268.38238600000005
- Max Citation Score: 295.8875700000001
- Similarity Product: 173.9100232043839

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test