PATENT CLAIM ANALYSIS

Application Number: 15984009
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-01
Patent Classification: ["544", "277000"]

Abstract:
Purine scaffold Hsp90 inhibitors are useful in therapeutic applications and as radioimaging ligands.

Claim (Index 1):
A compound of the formula:\n left side-linker-right side wherein (a) the left side has the formula: in which:\n X 6  is NH 2  \n X 3  is hydrogen or halogen and \n X 1  is hydrogen,\n a C 1  to C 10  alkyl, alkenyl, or alkynyl group, \n a C 1  to C 10  saturated or unsaturated hydrocarbon including a heteroatom in place of a carbon atom, or \n \n a targeting or labeling moiety, \n (b) the linker is selected from the group consisting of CH 2 , O, NH and S, and (c) the right side has the formula:\n -six-membered aryl ring-(X 2 )(X 4 )(X 5 ) \n wherein\n X 2  is disposed at the two-position of the aryl ring and is halogen, alkyl, alkoxy, halogenated alkoxy, hydroxyalkyl, pyrollyl, optionally substituted aryloxy, alkylamino, dialkylamino, carbamyl, amido, alkylamido dialkylamido, acylamino, alkylsulfonylamido, trihalomethoxy, trihalocarbon, thioalkyl, SO 2 -alkyl, COO-alkyl, NH 2 , OH, CN, SO 2 X 7 , NO 2 , NO, C\u2550SR 2 , NSO 2 X 7 , C\u2550OR 2 , where X 7  is F, NH 2 , alkyl or H, and R 2  is alkyl, NH 2 , NH-alkyl or O-alkyl; and \n X 4  and X 5 , which may be the same or different, are disposed at the 4 and 5 positions of the aryl ring and \n wherein X 4  and X 5  are selected from halogen, alkyl, alkoxy, halogenated alkoxy, hydroxyalkyl, pyrollyl, optionally substituted aryloxy, alkylamino, dialkylamino, carbamyl, amido, alkylamido dialkylamido, acylamino, alkylsulfonylamido, trihalomethoxy, trihalocarbon, thioalkyl, SO 2 -alkyl, COO-alkyl, NH 2 , OH, CN, SO 2 X 7 , NO 2 , NO, C\u2550SR 2 , NSO 2 X 7 , C\u2550OR 2 , where X 5  is F, NH2, alkyl or H, and R 2  is alkyl, NH 2 , NH-alkyl or O-alkyl, C 1  to C 6  alkyl or alkoxy; or \n wherein X 4  and X 5  taken together have the formula \u2014O\u2014(CH 2 ) n \u2014O\u2014, wherein n is an integer from 0 to 2, or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 93.0
- Lexical Diversity: 1.0
- Patent Class: 544.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13176903', '15218524', '15620865', '14256510', '11814506']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8276028382003021
- 35 USC 102 Novelty (BERT): 0.5259606747043656
- Combined Prediction Score: 0.7974386218507085
- Mean Citation Score: 330.078242
- Max Citation Score: 364.29672
- Similarity Product: 317.0957033000278

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test