PATENT CLAIM ANALYSIS

Application Number: 15916950
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["423", "514000"]

Abstract:
Provided herein are pharmaceutically acceptable sodium thiosulfate and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-purgeable organic carbon in a sodium thiosulfate-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium thiosulfate. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium thiosulfate.

Claim (Index 21):
A pharmaceutical composition comprising sodium thiosulfate pentahydrate and one or more pharmaceutically acceptable carriers or excipients, wherein the sodium thiosulfate pentahydrate contains no greater than 8 ppm of non-purgeable organic carbon, contains no greater than 0.05 ppm of mercury, contains no greater than 2 ppm of aluminum, contains no greater than 0.003% by weight of selenium, contains no less than 98% by weight and no greater than about 102% by weight of sodium thiosulfate on an anhydrous basis measured by ion chromatography, has a water content between 32% and 37% by weight, has a heavy metal content of no greater than 10 ppm, contains no greater than 200 ppm of chloride, contains no greater than 0.001% by weight of sulfide, contains no greater than 0.002% by weight of iron, contains no greater than 0.01% by weight of calcium, contains no greater than 0.005% by weight of potassium, contains no greater than 0.1% of sulfite, contains no greater than 0.5% of sulfate, contains no greater than 3 ppm of arsenic, contains no greater than 0.001% by weight of lead, has total aerobic count of microbial load of no greater than 100 CFU/g, has total yeast and mold count of no greater than 20 CFU/g, contains no greater than 0.02 EU/mg of bacterial endotoxins, contains no greater than 0.002% by weight of nitrogen compounds, contains no greater than 0.005% by weight of insoluble matter, contains no greater than 0.01% by weight of residual anti-caking agent, and contains no greater than ICH Q3C (R3) limits of organic volatile impurities, wherein a 10% aqueous solution of the solid sodium thiosulfate pentahydrate at 25\u00b0 C. is colorless and has a pH between 6.0 and 8.0, and wherein the solid sodium thiosulfate pentahydrate is odorless crystals,\n wherein the pharmaceutical composition is formulated for parenteral administration; and \n wherein the pharmaceutically acceptable carrier or excipient is an aqueous vehicle; a water-miscible vehicle; a non-aqueous vehicle; an antimicrobial agent or preservative against the growth of microorganisms; a stabilizer; a solubility enhancer; an isotonic agent; a buffering agent; an antioxidant; a local anesthetic; a suspending or dispersing agent; a wetting or emulsifying agent; a complexing agent; a sequestering or chelating agent; a cryoprotectant; a lyoprotectant; a thickening agent; a pH adjusting agent; or an inert gas.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 90.0
- Lexical Diversity: 1.73529
- Patent Class: 423.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14310133', '15252324', '15409659', '15137082', '12831331']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7754299427489478
- 35 USC 102 Novelty (BERT): 0.5397250027728859
- Combined Prediction Score: 0.7518594487513417
- Mean Citation Score: 362.353396
- Max Citation Score: 373.2407
- Similarity Product: 370.5178599439144

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test