PATENT CLAIM ANALYSIS

Application Number: 15887214
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["546", "160000"]

Abstract:
Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR 1  or N; B is CR 3  or N; D is CR 4  or N; L 1  is —(CR 7 R 7 ) m —; L 2  is —(CR 7 R 7 ) n —; and X, Z, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6  are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Claim (Index 2):
The compound according to  claim 1  or a salt thereof, wherein zero or one of A, B, and D is N; and wherein:\n X is a bond, \u2014O\u2014, \u2014S\u2014, or \u2014NR 8 \u2014; \n Z is a cyclic group selected from C 3-6  cycloalkyl, C 4-6  cycloalkenyl, 5- to 10-membered heterocyclyl, phenyl, and 5- to 10-membered heteroaryl, wherein said cyclic group is substituted with zero to 3 R a ; \n R 1  is H, F, Cl, \u2014CN, \u2014CH 3 , \u2014CH 2 F, \u2014CHF 2 , \u2014CF 3 , or \u2014OCH 3 ; \n R 2  is H, R 1a , C 1-3  fluoroalkyl, C 2-4  alkenyl substituted with zero to 6 R 1a , C 2-4  alkynyl substituted with zero to 4 R 1a , \u2014(CR g R g ) r (3- to 14-membered carbocyclyl substituted with zero to 3 R 1a ), \u2014(CR g R g ) r (phenyl substituted with zero to 3 R 1a ), \u2014(CR g R g ) r (5- to 7-membered heterocyclyl substituted with zero to 3 R 1a ), or \u2014(CR g R g ) r (mono- or bicyclic heteroaryl substituted with zero to 3 R 1a ); \n R 3  is H, F, Cl, \u2014CN, \u2014OH, C 1-2  alkyl, \u2014CF 3 , \u2014OCH 3 , \u2014OCF 3 , \u2014NH 2 , \u2014(CH 2 ) r (phenyl substituted with zero to 3 R 1a ), \u2014(CH 2 ) r (3- to 14-membered carbocyclyl substituted with zero to 3 R 1a ), \u2014(CH 2 ) r (phenyl substituted with zero to 3 R 1a ), \u2014(CH 2 ) r (5- to 7-membered heterocyclyl substituted with zero to 3 R 1a ), or \u2014(CH 2 ) r (monocyclic heteroaryl substituted with zero to 3 R 1a ); \n R 4  is H, F, Cl, \u2014CN, C 1-2  alkyl, C 1-2  fluoroalkyl, or C 1-2  alkoxy; \n R 5  is H, F, Cl, \u2014OH, C 1-3  alkyl substituted with zero to 6 R a , C 3-6  cycloalkyl substituted with zero to 6 R a , C 1-3  alkoxy substituted with zero to 6 R a , \u2014C(O)OR h , \u2014C(O)NR h R h , or \u2014NR h R h ; \n each R 7  is independently H, \u2014OH, C 1-3  alkyl, C 1-3  fluoroalkyl, C 1-3  hydroxyalkyl, C 1-2  aminoalkyl, \u2014CH 2 CH\u2550CH 2 , C 3-6  cycloalkyl, phenyl or \u2014NR h R h ; or two R 7  along with the carbon atom to which they are attached form a 3- to 7-membered spirocarbocyclyl group; \n m is zero, 1, or 2; \n n is zero, 1, 2, or 3; and \n each r is zero, 1, or 2.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 88.0
- Lexical Diversity: 2.06897
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15749611', '15558692', '15558708', '15558724', '14588470']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.842384830497874
- 35 USC 102 Novelty (BERT): 0.5629506083673931
- Combined Prediction Score: 0.8144414082848259
- Mean Citation Score: 430.14112400000016
- Max Citation Score: 456.6969
- Similarity Product: 386.1366538192928

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test