PATENT CLAIM ANALYSIS

Application Number: 15910677
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "064000"]

Abstract:
A method is disclosed for altering the redox equilibrium of a transmembrane receptor-like protein tyrosine phosphatase (RPTP), particularly a type IIa RPTP, by chemically modulating the activity through contact of such an enzyme with a diaryl boron compound that preferentially reacts with an RPTP in an oxidized state (CyS-OH). This redox modulation is most readily observed and put to use by assaying the inhibition of the phosphatase activity of the RPTP. Such an assay can be carried out on an enzyme in vitro or by contacting the enzyme in a living organism (in vivo). A useful diaryl boron compound corresponds in structure to Formula I in which Ar-1, Ar-2, R 1 , R 2 , R 3  and R 4  are defined within. A pharmaceutical composition containing a useful diaryl boron compound is also disclosed, as are particularly preferred diaryl boron compounds.

Claim (Index 21):
A method of inhibiting the phosphatase activity of a membrane-bound protein tyrosine phosphatase (PTP) that comprises the steps of contacting said PTP with an effective amount of a boron-containing compound of Formula IIIb, and maintaining said contact for as long a time period as desired to inhibit said phosphatase activity, wherein R 1  and R 2  are the same or different substituents that are selected from one or more of the group consisting of hydrogen, halogen, C 1 -C 6 -hydrocarbyl, trifluoromethyl, cyano, nitro, phenyl, optionally substituted phenyl, benzoyl, optionally substituted benzoyl, C 1 -C 6 -hydrocarbyloxycarbonyl, carbamoyl, mono- and di-C 1 -C 6 -hydrocarbyl carbamoyl, sulfamoyl, mono- and di-C 1 -C 6 -hydrocarbyl sulfamoyl, wherein said optional substituent is selected from said R 1  and R 2  substituents other than hydrogen, phenyl and benzoyl, and with the proviso that the sum of Hammett sigma functions for para and/or meta substituents, as appropriate, of the depicted R 1  and R 2  groups is greater than about zero.

Metadata:
- Claim Count in Document: 116.0
- Percentile: 90.0
- Lexical Diversity: 1.73626
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11280724', '10777186', '11219402', '12043872', '11508605']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7459105067648043
- 35 USC 102 Novelty (BERT): 0.5032365905810982
- Combined Prediction Score: 0.7216431151464338
- Mean Citation Score: 225.159968
- Max Citation Score: 234.57724
- Similarity Product: 165.076297638545

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test