PATENT CLAIM ANALYSIS

Application Number: 16060754
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "009363"]

Abstract:
The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

Claim (Index 1):
A compound of formula (I) where: R is \u2014CH(R 1 )\u2014COOH, where:\n R 1  is H or a C 1 -C 3  alkyl chain that is optionally substituted by a C 1 -C 3  alkoxy or C 1 -C 3  hydroxyalkoxy group; \n n is 1 or 2; R 2  is selected from the group consisting of: an aryl ring; a cyclohexyl ring; a C 1 -C 5  alkyl substituted by one or more hydroxyalkoxy groups, or by a cycloalkyl ring; a group of formula \u2014(CH 2 ) s CH(R 3 )-G; and a C 5 -C 12  hydroxyalkyl comprising at least 2 hydroxyl groups; in which\n s is 0, 1 or 2; \n R 3  is H, or an arylalkylene or cycloalkyl-alkylene having from 1 up to 3 carbon atoms in the alkylene chain; \n G is a group selected from \u2014PO(OR 4 ) 2 , \u2014PO(R 5 )(OR 4 ) and \u2014COOH; in which \n R 4  independently of one another is H or C 1 -C 5 alkyl; \n R 5  is an aryl or a cyclohexyl ring, or C 1 -C 5  alkyl which is optionally substituted by an aryl or cyclohexyl ring; and \n L is a C 1 -C 6  alkylene, optionally interrupted by one or more \u2014N(R\u2032 2 )\u2014 groups, and optionally substituted by one or more substituent groups selected from hydroxyl, C 1 -C 3  alkoxy and C 1 -C 3  hydroxyalkoxy, where R\u2032 2  is, independently, as defined for R 2  as well as individual diastereoisomers and their racemic mixtures, geometric isomers and solved enantiomers of the same, and the physiologically acceptable salt thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 1.10526
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['11630605', '11630600', '14384414', '11165793', '09752867']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7424769615273218
- 35 USC 102 Novelty (BERT): 0.5085990433857366
- Combined Prediction Score: 0.7190891697131633
- Mean Citation Score: 276.48429400000003
- Max Citation Score: 293.58987
- Similarity Product: 223.02352997180165

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test