PATENT CLAIM ANALYSIS

Application Number: 15860506
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "186100"]

Abstract:
Methods for determining the susceptibility or resistance of bacteria to antibiotic agents are provided. In one embodiment, the methods include culturing the bacteria in the presence or absence or the antimicrobial agent to generate a primary culture which is then cultured in the presence or absence of transforming phages. The recombinant phages are specific to the bacteria and comprise a heterologous marker (e.g., a nucleic acid that is expressible as a detectable product such as an RNA or a protein). The susceptibility or resistance of the bacteria to the antimicrobial agent may be determined by assaying the culture for the presence or absence of the heterologous marker, wherein a reduction in the level or activity of the marker in the culture compared to the level or activity of the marker in a comparative culture indicates that the bacteria is sensitive to the antibiotic agent.

Claim (Index 12):
A method for simultaneous identification of a bacteria species in a sample and determination of its susceptibility to an antimicrobial agent, comprising:\n (a) culturing a sample with an antimicrobial agent to generate a primary culture; (b) culturing the primary culture with a transforming phage specific to a bacteria species and which is engineered to express a heterologous marker; and (c) detecting presence or absence of the marker, where presence of the marker indicates presence of the bacteria species in the sample and its resistance to the antimicrobial agent.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 86.0
- Lexical Diversity: 2.15493
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12812212', '09600398', '14119716', '13224776', '15161857']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7306828450958173
- 35 USC 102 Novelty (BERT): 0.4805813221432972
- Combined Prediction Score: 0.7056726928005653
- Mean Citation Score: 216.71058
- Max Citation Score: 220.99445
- Similarity Product: 179.74802733491364

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test