PATENT CLAIM ANALYSIS

Application Number: 15978815
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["536", "025310"]

Abstract:
The invention comprises GalNAc phosphoramidite derivatives of the formula I wherein R 1  is a hydroxy protecting group, n is an integer from 0 to 10 and m is an integer from 0 to 20 and its corresponding enantiomers and/or optical isomers thereof. The invention further comprises a process for the preparation of the GalNAc phosphoramidite derivatives of the formula I and its use in the preparation of therapeutically valuable GalNAc-cluster oligonucleotide conjugates.

Claim (Index 18):
The method of  claim 16 , wherein the GalNAc-cluster oligonucleotide conjugate comprises: (COMP\u2003NO\u20031) GalNAc-cluster-AM-C6-5\u2032-caG S m C S G S t S a S a S a S g S a S g S a S G S   G-3\u2032;   (COMP\u2003NO\u20032) GalNAc-cluster-AM-C6-5\u2032-caG S m C S G S t S a S a S a S g S a S g S a S G S   G S T-3\u2032;   (COMP\u2003NO\u20033) GalNAc-cluster-AM-C6-5\u2032-caG S m C S G S t S a S a S a S g S a S g S A S G S   G-3\u2032;   (COMP\u2003NO\u20034) GalNAc-cluster-AM-C6-5\u2032-caG S G S m C S G S t S a S a S a S g S a S g S a S   G S G-3\u2032;   (COMP\u2003NO\u20035) GalNAc-cluster-AM-C6-5\u2032-caA S G S m C S g S a S a S g S t S g S c S a S c S   A S m C S G-3\u2032;   (COMP\u2003NO\u20036) GalNAc-cluster-AM-C6-5\u2032-caA S G S m C S g S a S a S g S t S g S c S a S c S   a S C S G S G-3\u2032;   (COMP\u2003NO\u20037) GalNAc-cluster-AM-C6-5\u2032- (5-Br) caG S m C S G S t S a S a S a S g S a S g S   a S G S G-3\u2032;   (COMP\u2003NO\u20038) GalNAc-cluster-AM-C6-5\u2032-cagcgtaaagagagg-3\u2032;   (COMP\u2003NO\u20039) GalNAc-cluster-AM-C6 S -5\u2032-A S A S T S g S c S t S a S c S a S a S a S a S c S   C S C S A-3\u2032; wherein, AM-C6 is a 6-aminohexyl-1-phosphate or 1-thiophosphate linkage; uppercase letters denote beta-D-oxy-LNA units; lowercase letters denote DNA units; s is a phosphorothioate linkage; m is a DNA or beta-D-oxy-LNA unit containing a 5-methylcytosine base; and 5 Br is a DNA unit containing a 5-bromocytosine base.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 93.0
- Lexical Diversity: 1.58333
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15890181', '15363490', '14398317', '15534676', '15033715']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5909407027463585
- 35 USC 102 Novelty (BERT): 0.529665938588676
- Combined Prediction Score: 0.5848132263305902
- Mean Citation Score: 232.891198
- Max Citation Score: 331.60925
- Similarity Product: 218.88557528778907

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test