PATENT CLAIM ANALYSIS

Application Number: 16371304
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-07
Patent Classification: ["514", "04400R"]

Abstract:
The invention relates to an RNA comprising at least one open reading frame (ORF) and comprising at least one modification, which increases the expression of the encoded peptide or protein. Furthermore, the invention relates to the medical use of such a modified RNA administered to a subject by jet injection. The invention relates further to a pharmaceutical composition and to a kit of parts comprising said modified RNA for administration by jet injection, preferably for use in the field of gene therapy and/or genetic vaccination. Additionally, the invention relates to a method for enhancing the (localized) expression of RNA-encoded peptides or proteins in the dermis or muscle (of a mammal) comprising administering the modified RNA by jet injection. And finally, the invention relates to a method of treatment comprising administering the modified RNA by jet injection to a subject in need thereof.

Claim (Index 15):
The modified RNA for use according to  claim 8 , wherein the modified RNA comprises the following modifications: a modification of the G/C content, at least one UTR modification, a poly(A) tail with more than 30 adenosine nucleotides, and a histone stem-loop sequence.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 100.0
- Lexical Diversity: 2.19444
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15048031', '15482117', '16233031', '16286400', '14714871']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7390295754748906
- 35 USC 102 Novelty (BERT): 0.5388623434842603
- Combined Prediction Score: 0.7190128522758276
- Mean Citation Score: 277.088188
- Max Citation Score: 370.94574
- Similarity Product: 261.9655974272561

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test