PATENT CLAIM ANALYSIS

Application Number: 16155220
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["435", "006140"]

Abstract:
The present invention relates to a gene for predicting or diagnosing the prognosis of early-stage breast cancer and to a use thereof, and more specifically relates to a genetic marker for predicting or diagnosing the prognosis of breast cancer, including TRBC1 (T cell receptor beta constant 1), BTN3A2 (butyrophilin, subfamily 3, member A2) or HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) for providing information necessary for predicting or diagnosing the prognosis of a breast cancer patient. The genetic marker of the present invention allows the prediction or diagnosis of the prognosis of a breast cancer patient, and can therefore advantageously be used for the purpose of providing a direction as to the future course of breast cancer treatment, including a decision on whether anticancer therapy is necessary.

Claim (Index 1):
A method for diagnosing a prognosis of breast cancer and treating breast cancer in a breast cancer patient, the method comprising the steps of:\n collecting a sample from the breast cancer patient; isolating mRNA from the sample of the breast cancer patient; measuring a first mRNA expression level for the mRNA of at least one i-gene selected from the group consisting of BTN3A2 (butyrophilin, subfamily 3, member A2), T cell receptor beta constant 1 (TRBC1), and major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), and a second mRNA expression level for the mRNA of at least one p-gene selected from the group consisting of the p-genes of the following Table 1; normalizing the first and second mRNA expression levels to determine a normalized value; diagnosing the prognosis of breast cancer patient by using the determined normalized value of the first and second mRNA expression levels, wherein an overexpression of the i-gene indicates a good prognosis of breast cancer, while an overexpression of the p-gene indicates a poor prognosis of breast cancer; and treating the diagnosed breast cancer patient by administering at least one of an anti-cancer agent, a surgery and a radiation therapy. TABLE 1 List of p-genes No. Gene ID Gene Name 1 APITD1 apoptosis-inducing, TAF9-like domain 1 2 BID BH3 interacting domain death agonist 3 BUB1B BUB1 mitotic checkpoint serine/threonine  kinase B 4 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 5 CKS1B CDC28 protein kinase regulatory subunit 1B 6 CKS2 CDC28 protein kinase regulatory subunit 2 7 DLGAP5 discs, large (Drosophila) homolog-associated  protein 5 8 POLA1 polymerase (DNA directed), alpha 1, catalytic  subunit 9 POLA2 polymerase (DNA directed), alpha 2, accessory  subunit 10 DSCC1 DNA replication and sister chromatid cohesion 1 11 DNA2 DNA replication helicase/nuclease 2 12 E2F8 E2F transcription factor 8 13 ERCC6L excision repair cross-complementation group 6-like 14 FBXO5 F-box protein 5 15 FANCI Fanconi anemia, complementation group I 16 GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 17 GINS1 GINS complex subunit 1 (Psf1 homolog) 18 GINS2 GINS complex subunit 2 (Psf2 homolog) 19 MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 20 MAD2L1BP MAD2L1 binding protein 21 MIS18A MIS18 kinetochore protein A 22 MYBL2 v-myb avian myeloblastosis viral oncogene  homolog-like 2 23 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic  subunit 24 NEK2 NIMA-related kinase 2 25 NSL1 NSL1, MIS12 kinetochore complex component 26 PBK PDZ binding kinase 27 RAB11A RAB11A, member RAS oncogene family 28 RAD51C RAD51 paralog C 29 RAD54B RAD54 homolog B (S. cerevisiae) 30 RANBP1 RAN binding protein 1 31 RALA v-ral simian leukemia viral oncogene homolog A  (ras related) 32 RACGAP1  Rac GTPase activating protein 1 33 SSNA1 Sjogren syndrome nuclear autoantigen 1 34 STAMBP STAM binding protein 35 SSSCA1 Sjogren syndrome/scleroderma autoantigen 1 36 TAF2 TAF2 RNA polymerase II, TATA box binding  protein (TBP)-associated factor, 150 kDa 37 TIPIN TIMELESS interacting protein 38 TIPRL TOR signaling pathway regulator 39 TRIAP1 TP53 regulated inhibitor of apoptosis 1 40 TTK TTK protein kinase 41 ZWINT ZW10 interacting kinetochore protein 42 ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 43 AURKA aurora kinase A 44 AURKB aurora kinase B 45 BRD7 bromodomain containing 7 46 CSNK2A1 casein kinase 2, alpha 1 polypeptide 47 CDC20 cell division cycle 20 48 CDC25C cell division cycle 25C 49 CENPA centromere protein A 50 CENPE centromere protein E, 312 kDa 51 CENPF centromere protein F, 350/400 kDa 52 CENPI centromere protein I 53 CENPM centromere protein M 54 CENPN centromere protein N 55 CENPU centromere protein U 56 CEP55 centrosomal protein 55 kDa 57 CHEK1 checkpoint kinase 1 58 CDT1 chromatin licensing and DNA replication factor 1 59 C11orf80 chromosome 11 open reading frame 80 60 CCNA2 cyclin A2 61 CCNB1 cyclin B1 62 CCNB2 cyclin B2 63 CCNE2 cyclin E2 64 CDK1 cyclin-dependent kinase 1 65 CDKN3 cyclin-dependent kinase inhibitor 3 66 CKAP5 cytoskeleton associated protein 5 67 DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 68 DCTN2 dynactin 2 (p50) 69 DYNLT1 dynein, light chain, Tctex-type 1 70 ECD ecdysoneless homolog (Drosophila) 71 ECT2 epithelial cell transforming 2 72 EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 73 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 74 EZR ezrin 75 FEN1 flap structure-specific endonuclease 1 76 FOXM1 forkhead box M1 77 GSK3B glycogen synthase kinase 3 beta 78 HMGN5 high mobility group nucleosome binding domain 5 79 INTS7 integrator complex subunit 7 80 KIF11 kinesin family member 11 81 KIF14 kinesin family member 14 82 KIF20A kinesin family member 20A 83 KIF23 kinesin family member 23 84 KIF2C kinesin family member 2C 85 KIF4A kinesin family member 4A 86 KIFC1 kinesin family member C1 87 MIF macrophage migration inhibitory factor  (glycosylation-inhibiting factor) 88 MELK maternal embryonic leucine zipper kinase 89 MED 1 mediator complex subunit 1 90 MCM10 minichromosome maintenance complex  component 10 91 MCM2 minichromosome maintenance complex  component 2 92 MCM6 minichromosome maintenance complex  component 6 93 MAP2K1 mitogen-activated protein kinase kinase 1 94 MSH6 mutS homolog 6 95 MLF1 myeloid leukemia factor 1 96 NCAPG non-SMC condensin I complex, subunit G 97 NUSAP1 nucleolar and spindle associated protein 1 98 NUP155 nucleoporin 155 kDa 99 NUP93 nucleoporin 93 kDa 100 ORC4 origin recognition complex, subunit 4 101 ORC5 origin recognition complex, subunit 5 102 PIN1 peptidylprolyl cis/trans isomerase,  NIMA-interacting 1 103 PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 104 PTTG1 pituitary tumor-transforming 1 105 PTTG3P pituitary tumor-transforming 3, pseudogene 106 PLK1 polo-like kinase 1 107 PLK4 polo-like kinase 4 108 PRIM1 primase, DNA, polypeptide 1 (49 kDa) 109 PA2G4 proliferation-associated 2G4, 38 kDa 110 LEPREL4 leprecan-like 4 111 PSMC3 proteasome (prosome, macropain) 26S subunit,  ATPase, 3 112 PSMC6 proteasome (prosome, macropain) 26S subunit,  ATPase, 6 113 PSMD10 proteasome (prosome, macropain) 26S subunit,  non-ATPase, 10 114 PSMD12 proteasome (prosome, macropain) 26S subunit,  non-ATPase, 12 115 PSMD14 proteasome (prosome, macropain) 26S subunit,  non-ATPase, 14 116 PSMD2 proteasome (prosome, macropain) 26S subunit,  non-ATPase, 2 117 PSMD3 proteasome (prosome, macropain) 26S subunit,  non-ATPase, 3 118 PSMD4 proteasome (prosome, macropain) 26S subunit,  non-ATPase, 4 119 PSMD6 proteasome (prosome, macropain) 26S subunit,  non-ATPase, 6 120 PSMD7 proteasome (prosome, macropain) 26S subunit,  non-ATPase, 7 121 PSMA1 proteasome (prosome, macropain) subunit,  alpha type, 1 122 PSMA2 proteasome (prosome, macropain) subunit,  alpha type, 2 123 PSMA3 proteasome (prosome, macropain) subunit,  alpha type, 3 124 PSMA4 proteasome (prosome, macropain) subunit,  alpha type, 4 125 PSMA6 proteasome (prosome, macropain) subunit,  alpha type, 6 126 PSMA7 proteasome (prosome, macropain) subunit,  alpha type, 7 127 PSMB3 proteasome (prosome, macropain) subunit,  beta type, 3 128 PSMB5 proteasome (prosome, macropain) subunit,  beta type, 5 129 PSMB7 proteasome (prosome, macropain) subunit,  beta type, 7 130 PRMT1 protein arginine methyltransferase 1 131 PPP2R3B protein phosphatase 2, regulatory subunit B\u2033, beta 132 PPP3CA protein phosphatase 3, catalytic subunit, alpha  isozyme 133 PRC1 protein regulator of cytokinesis 1 134 RRM2 ribonucleotide reductase M2 135 RPS6KB1 ribosomal protein S6 kinase, 70 kDa,  polypeptide 1 136 SPAG5 sperm associated antigen 5 137 SKA1 spindle and kinetochore associated complex  subunit 1 138 STMN1 stathmin 1 139 SLBP stem-loop binding protein 140 SMC2 structural maintenance of chromosomes 2 141 SMC4 structural maintenance of chromosomes 4 142 SMC5 structural maintenance of chromosomes 5 143 TERF1 telomeric repeat binding factor (NIMA- interacting) 1 144 TXNL4A thioredoxin-like 4A 145 TRIP13 thyroid hormone receptor interactor 13 146 TOP2A topoisomerase (DNA) II alpha 170 kDa 147 TFDP2 transcription factor Dp-2 (E2F dimerization  partner 2) 148 TACC3 transforming, acidic coiled-coil containing  protein 3 149 TUBB3 tubulin, beta 3 class III 150 TUBB4B tubulin, beta 4B class IVb 151 TUBB tubulin, beta class I 152 TSG101 tumor susceptibility 101 153 UBE2C ubiquitin-conjugating enzyme E2C 154 UBE2L3 ubiquitin-conjugating enzyme E2L 3 155 UBE2S ubiquitin-conjugating enzyme E2S 156 USP9X ubiquitin specific peptidase 9, X-linked 157 VRK1 vaccinia related kinase 1 158 ZFHX3 zinc finger homeobox 3 159 ZWILCH zwilch kinetochore protein 160 MMP11 Matrix Metallopeptidase 11

Metadata:
- Claim Count in Document: 9.0
- Percentile: 97.0
- Lexical Diversity: 1.97297
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13737349', '12214782', '12757931', '13584369', '10268730']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6431096082450007
- 35 USC 102 Novelty (BERT): 0.5376377342659456
- Combined Prediction Score: 0.6325624208470952
- Mean Citation Score: 357.28054000000014
- Max Citation Score: 401.77496
- Similarity Product: 283.2268416448498

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test