PATENT CLAIM ANALYSIS

Application Number: 15901503
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["558", "413000"]

Abstract:
The invention relates to novel chemical entities that act as thromboxane (TX) A 2  receptor, or T prostanoid receptor (TP), antagonists and to their use in the treatment of human diseases in which thromboxane (TX) A and of all other agents that act as incidental ligands of TP, including the endoperoxide prostaglandin (PG)G 2 /PGH 2 , 20-hydroxyeicosatetraenoic acid (20-HETE) and the free-radical derived isoprostanes (e.g., 8-iso-prostaglandin (PG)F 2α ), play a role. Compounds of the invention preferably include a benzenesulfonyl urea in which the benzene is substituted by a substituted biphenylyloxy group (e.g., at the 2 position) and by a nitrile group (e.g., at the 5 position), which compounds show promising results as TP-isoform selective TP antagonists.

Claim (Index 2):
A method of treating pulmonary arterial hypertension, method comprising:\n administering to a patient affected by pulmonary arterial hypertension a compound represented by formula (I): wherein:\n R 1  is selected from the group consisting of: a cycloalkyl group, an aryl group, a heterocycloalkyl group, a difluoromethyl group, a halogenated cycloalkyl group, a halogenated aryl group, a halogenated heterocycloalkyl group, a halogenated methoxy group, an ethoxy group, an isopropoxy group, a tert-butoxy group, a halogenated ethoxy group, a halogenated isopropoxy group, a halogenated tert-butoxy group, a primary amide, a secondary amide, a tertiary amide, a nitrile group, an isopropyl ester group, a tert-butyl ester group, a halogenated methyl ester group, a halogenated ethyl ester group, a halogenated isopropyl ester group, and a halogenated tert-butyl ester group; and \n R 2  is selected from the group consisting of a halogen, an alkyl group, a halogenated alkyl group, an aryl group, and a halogenated aryl group, \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 33.0
- Percentile: 88.0
- Lexical Diversity: 1.86076
- Patent Class: 558.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15180805', '14391856', '15460910', '15349379', '15178931']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7881971430871996
- 35 USC 102 Novelty (BERT): 0.6647152389953569
- Combined Prediction Score: 0.7758489526780153
- Mean Citation Score: 586.388146
- Max Citation Score: 777.21484
- Similarity Product: 567.502582074542

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test