PATENT CLAIM ANALYSIS

Application Number: 16218658
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["424", "205100"]

Abstract:
Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy. Related methods of treating or preventing cancer using the T cells are also disclosed.

Claim (Index 32):
A method of treating or preventing head and neck squamous-cell carcinoma in a human, the method comprising:\n (a) dividing a head and neck squamous-cell carcinoma tumor sample into multiple fragments; (b) culturing the multiple fragments in the presence of at least one cytokine; (c) obtaining T-cells from the cultured fragments; (d) expanding the number of T-cells to produce an expanded population of HPV-specific T-cells using\n one or both of (i) irradiated allogenic feeder cells and (ii) irradiated autologous feeder cells; and \n one or both of (iii) OKT3 antibody and (iv) interleukin-2; \n (e) optionally, adding a second culturing step following (c); (f) administering to the human nonmyleoablative lymphodepleting chemotherapy, and (g) administering the population of head and neck squamous-cell carcinoma tumor-specific T-cells to the human in an amount effective to treat or prevent the head and neck squamous cell carcinoma in the human.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 98.0
- Lexical Diversity: 1.71186
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15786966', '14905108', '15313673', '14453286', '15331659']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7464434802701613
- 35 USC 102 Novelty (BERT): 0.5636026806640145
- Combined Prediction Score: 0.7281594003095466
- Mean Citation Score: 411.782994
- Max Citation Score: 447.90112
- Similarity Product: 348.28630477853767

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test