PATENT CLAIM ANALYSIS

Application Number: 15886578
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "047000"]

Abstract:
A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base 1 , Base 2 , Y, Y a , X a , X a1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3 , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , and R 8a  are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Claim (Index 14):
The compound selected from a compound according to  claim 11  pharmaceutically acceptable salts thereof, wherein the compound of formula (I\u2032) is a compound of formula (I\u2032c): or a pharmaceutically acceptable salt thereof, wherein\n Base 1  and Base 2  are each independently selected from the group consisting of \n where Base 1  and Base 2  each may be independently substituted by 0-3 substituents R 10 , where each R 10  is independently selected from the group consisting of F, Cl, I, Br, OH, SH, NH 2 , C 1-3  alkyl, C 3-6  cycloalkyl, O(C 1-3  alkyl), O(C 3-6  cycloalkyl), S(C 1-3  alkyl), S(C 3-6  cycloalkyl), NH(C 1-3  alkyl), NH(C 3-6  cycloalkyl), N(C 1-3  alkyl) 2 , and N(C 3-6  cycloalkyl) 2 ;\n X c  and X c1  are each independently selected from the group consisting of OR 9 , SR 9 , and NR 9 R 9 ; \n R 3  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N 3 , C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl, where said R 3  C 1 -C 6  alkyl or C 1 -C 6  haloalkyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, and OH; \n R 4  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N 3 , C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl, where said R 4  C 1 -C 6  alkyl or C 1 -C 6  haloalkyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, and OH; \n R 5  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, NH 2 , N 3 , C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl, where said R 5  C 1 -C 6  alkyl or C 1 -C 6  haloalkyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, and OH; \n R 6a  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N 3 , C 1 -C 6  alkyl, and C 1 -C 6  haloalkyl, where said R 6a  C 1 -C 6  alkyl or C 1 -C 6  haloalkyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, and OH; \n each R 9  is independently selected from the group consisting of H, C 2 -C 3  alkyl, \n where each R 9  C 2 -C 3  alkyl is optionally substituted by 1 to 2 substituents independently selected from the group consisting of OH, \u2014O\u2014C 1 -C 20  alkyl, \u2014S\u2014C(O)C 1 -C 6  alkyl, and C(O)OC 1 -C 6  alkyl; and\n optionally R 4  and R 5  are connected by C 1 -C 6  alkylene, \u2014O\u2014C 1 -C 6  alkylene, \u2014O\u2014C 2 -C 6  alkenylene, or \u2014O\u2014C 2 -C 6  alkynylene, such that where R 4  and R 5  are connected to form \u2014O\u2014C 1 -C 6  alkylene, \u2014O\u2014C 2 -C 6  alkenylene, or \u2014O\u2014C 2 -C 6  alkynylene, said O is bound at the R 5  position.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 88.0
- Lexical Diversity: 2.15152
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15234182', '15586634', '15368921', '15287805', '14068774']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8070597411909934
- 35 USC 102 Novelty (BERT): 0.5704570914799572
- Combined Prediction Score: 0.7833994762198898
- Mean Citation Score: 316.1777600000001
- Max Citation Score: 501.73862
- Similarity Product: 359.2071807078564

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test