PATENT CLAIM ANALYSIS

Application Number: 16087411
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-02
Patent Classification: ["435", "004000"]

Abstract:
The present disclosure relates to compositions, methods and test devices for determining the presence of active leukocyte cells, for example, by using novel LE and/or FINE substrates in an electrochemical assay.

Claim (Index 1):
A composition comprising a leukocyte enzyme substrate as depicted in one of Formula I, Formula II, Formula III: wherein A comprises one of an amino group or an ether group, B is a moiety capable of participating in a redox reaction, and C is an alcohol or amine blocking group; wherein X 1  and X 2  are independently O or NR a , and R a  is an H, an alkyl or an aryl group; Y 1  and Y 2  are independently O or NR a ; R 1  and R 2  are independently an alkyl or an aryl group; R 3  and R 4  are independently an alkyl, a protecting group or a peptide moiety; each of the R 5  on the ring is independently selected from the group consisting of a halogen atom; a hydroxyl group; a C 1 -C 6  alkyl group; a C 3 -C 6  cycloalkyl group; a C 3 -C 6  cycloalkyl C 1 -C 6  alkyl group; a C 2 -C 6  alkenyl group; a C 2 -C 6  alkynyl group; a C 1 -C 6  haloalkyl group (including trifluoro C 1 -C 6 alkyl); a C 2 -C 6  haloalkenyl group; a C 2 -C 6  haloalkynyl group; a C 3 -C 6  halocycloalkyl group; a C 3 -C 6  halocycloalkyl C 1 -C 6  alkyl group; a C 1 -C 6  alkoxy group; a C 3 -C 6  cycloalkyloxy group; a C 2 -C 6  alkenyloxy group; a C 2 -C 6  alkynyloxy group; a C 1 -C 6  alkylcarbonyloxy group; a C 1 -C 6  haloalkoxy group; a C 1 -C 6  alkylthio group; a C 1 -C 6  alkylsulfinyl group; a C 1 -C 6  alkylsulfonyl group; a C 1 -C 6  haloalkylthio group; a C 1 -C 6  haloalkylsulfinyl group; a C 1 -C 6  haloalkylsulfonyl group; an amino group; a C 1 -C 6  alkylcarbonylamino group; a mono(C 1 -C 6  alkyl)amino group; a di(C 1 -C 6  alkyl)amino group; a hydroxy C 1 -C 6  alkyl group; a C 1 -C 6  alkoxy C 1 -C 6  alkyl group; a C 1 -C 6  alkylthio C 1 -C 6  alkyl group; a C 1 -C 6  alkylsulfinyl C 1 -C 6  alkyl group; a C 1 -C 6  alkylsulfonyl C 1 -C 6  alkyl group; a C 1 -C 6  haloalkylthio C 1 -C 6  alkyl group; a C 1 -C 6  haloalkylsulfinyl C 1 -C 6  alkyl group; a C 1 -C 6  haloalkylsulfonyl C 1 -C 6  alkyl group; a cyano C 1 -C 6  alkyl group; a C 1 -C 6  alkoxy C 1 -C 6  alkoxy group; a C 3 -C 6  cycloalkyl C 1 -C 6  alkyloxy group; a C 1 -C 6  haloalkoxy C 1 -C 6  alkoxy group; a cyano C 1 -C 6  alkoxy group; a C 1 -C 6  acyl group; a C 1 -C 6  alkoxyimino C 1 -C 6  alkyl group; a carboxyl group; a C 1 -C 6  alkoxycarbonyl group; a carbamoyl group; a mono(C 1 -C 6  alkyl)aminocarbonyl group; a di(C 1 -C 6  alkyl)aminocarbonyl group; a nitro group; and a cyano group; and n is 0, 1, 2, 3, or 4; and wherein A 1 -A 2 -As-A 4  represent a core tetrapeptide scaffold sequence which serves as the enzyme active site, B comprises a moiety capable of participating in a redox reaction, and C comprises an acyl group.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.09375
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15314817', '12121213', '11254086', '13372758', '10714988']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5574155402472519
- 35 USC 102 Novelty (BERT): 0.4629281391213285
- Combined Prediction Score: 0.5479668001346596
- Mean Citation Score: 145.48082200000005
- Max Citation Score: 152.79095
- Similarity Product: 116.18786611451809

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test