PATENT CLAIM ANALYSIS

Application Number: 16094243
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["544", "297000"]

Abstract:
The present invention relates to new polymorphic forms of Crystalline Rosuvastatin calcium along with novel processes for crystalline as well as amorphous Rosuvastatin calcium.

Claim (Index 11):
A novel process for the preparation of stable Rosuvastatin Calcium crystalline Form M2 for the compound 7-[4-(4-flurophenyl)-6-isopropyl-2-(N-methyl-N-methyl sulfonyl amino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid Calcium salt which comprises\n a) Stirring of new polymorphic form \u2018M\u2019 of Rosuvastatin calcium in water b) Heating the reaction mass to 35-40\u00b0 C. by adding aq caustic solution c) Stirring of reaction mass for 30-40 minutes d) Addition of aliphatic ether selected from Diisopropyl ether, methyl tert butyl ether, dimethyl ether, diethyl ether or mixture thereof, e) Layer separation f) Filtration of aq. layer containing product via hyflow bed. g) Adjusted pH of aq. layer to 8.5-9.5 with dilute hydrochloric acid. h) Addition of calcium chloride solution i) Stirring to ensure complete crystallization j) Isolation of product as wet cake k) Drying of wet cake for 10-15 hours at 50-60\u00b0 C. l) Slurry washing of dried material of step xi) with aliphatic ether selected from Diisopropyl ether, methyl tert butyl ether, dimethyl ether, diethyl ether or mixture thereof, containing anti-oxidant/stabilizer like butylated hydroxyanisole, butylated hydroxytoluene or propyl gallate etc. m) Filtation & drying of material at 50-60\u00b0 C. to get stable Crystalline Form M2 of Rosuvastatin calcium.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 97.0
- Lexical Diversity: 1.13636
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13885509', '12449426', '13574005', '14901721', '13143943']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8280035974534865
- 35 USC 102 Novelty (BERT): 0.5457128237181792
- Combined Prediction Score: 0.7997745200799559
- Mean Citation Score: 386.299474
- Max Citation Score: 421.883
- Similarity Product: 310.06681104362013

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test