PATENT CLAIM ANALYSIS

Application Number: 15769904
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["435", "006110"]

Abstract:
The present invention provides a plurality of pairs of proximity probes, each pair being capable of binding to a different target analyte, wherein the first and second proximity probes of each pair of probes comprise universal oligonucleotides conjugated to their analyte binding moieties, and hybridised to the universal oligonucleotides are different tag oligonucleotides comprising universal complement domains common to all tag oligonucleotides and unique domains unique to each tag oligonucleotide, as well as methods for their production.

Claim (Index 1):
A method of manufacturing a plurality of pairs of proximity probes, wherein each pair of proximity probes comprises a first and a second proximity probe and each pair is capable of binding to a different target analyte, wherein each proximity probe comprises an analyte binding domain and a partially double-stranded nucleic acid domain and each proximity probe of a pair can simultaneously bind to a target analyte, and wherein the nucleic acid domains of a pair of proximity probes are able to interact directly or indirectly upon binding of the pair of proximity probes to their target analyte, said method comprising:\n a. conjugating a first universal oligonucleotide to each of a plurality of first analyte binding moieties, to form a set of first universal conjugates; b. conjugating a second universal oligonucleotide to each of a plurality of second analyte binding moieties, to form a set of second universal conjugates; c. hybridising to each first universal oligonucleotide of the set of first universal conjugates one of a plurality of different first tag oligonucleotides, each different first tag oligonucleotide comprising a first universal complement domain which is common to all first tag oligonucleotides and which is complementary to the first universal oligonucleotide, and a first unique domain which is unique to each different first tag oligonucleotide and which is not capable of hybridising to a first or second universal oligonucleotide, thereby to form a plurality of first proximity probes; d. hybridising to each second universal oligonucleotide of the set of second universal conjugates one of a plurality of different second cognate tag oligonucleotides, each different second tag oligonucleotide comprising a second universal complement domain which is common to all second tag oligonucleotides and which is complementary to the second universal oligonucleotide and a second unique domain which is unique to each different second tag oligonucleotide, and which is not capable of hybridising to a first or second universal oligonucleotide, thereby to form a plurality of second proximity probes; e. selecting multiple first proximity probes from said plurality of first proximity probes and multiple cognate second proximity probes from said plurality of second proximity probes, thereby to provide a plurality of pairs of proximity probes.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 91.0
- Lexical Diversity: 1.74468
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14116706', '15374135', '14442701', '12294031', '09785657']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5875843435188682
- 35 USC 102 Novelty (BERT): 0.5123692944405417
- Combined Prediction Score: 0.5800628386110356
- Mean Citation Score: 285.23016799999994
- Max Citation Score: 306.63593
- Similarity Product: 257.5913534682947

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test