PATENT CLAIM ANALYSIS

Application Number: 16087317
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["514", "260100"]

Abstract:
The invention describes a polymorph of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothiophene[3,2-d]pyrimidine-6-carboxylic acid maleate and a preparation method therefor. The polymorph is a crystal having high stability and low hygroscopicity, and the crystal form is selected from crystal form A, crystal form B and crystal form C. Furthermore, the crystal form has a strong in-vivo hypoglycemic activity and can be used for the preparation of a novel drug for the treatment or prevention of diabetes mellitus type H and/or complications of diabetes mellitus type H.

Claim (Index 4):
4. The crystal form of  claim 1 , wherein the crystal form B has one or more characteristics selected from the group consisting of:\n (1) the X-ray powder diffraction pattern of the crystal form B includes 3 or more 2\u03b8 values selected from the group consisting of: 5.37\u00b10.2\u00b0, 12.01\u00b10.2\u00b0, 14.93\u00b10.2\u00b0, 16.04\u00b10.2\u00b0, 20.09\u00b10.2\u00b0; and/or \n (2) the differential scanning calorimetry analysis spectrum (DSC spectrum) of the crystal form B has a characteristic peak within the range of 137\u00b15\u00b0 C.; and/or \n (3) the starting value of the endothermic transition temperature of the crystal form B is 127\u00b12\u00b0 C.; and/or \n (4) the thermogravimetric analysis pattern of the crystal form B includes 3 or more characteristic absorption peaks selected from the group consisting of: 119\u00b15\u00b0 C., 202\u00b15\u00b0 C., 284\u00b15\u00b0 C., 318\u00b15\u00b0 C.; and/or \n (5) the thermal weight loss of the crystal form B is 51-52 wt% at 400\u00b0 C.; and/or \n (6) the Raman spectrum of the crystal form B includes the following characteristic absorption peaks expressed by the wavelength \u03bb: 2234\u00b12 cm \u22121 , 1718\u00b12 cm \u22121 , 1693\u00b12 cm \u22121 , 1607\u00b12 cm \u22121 , 1565\u00b12 cm \u22121 , 1536\u00b12 cm \u22121 , 1476\u00b12 cm \u22121 , 1386\u00b12 cm \u22121 , 1349\u00b12 cm \u22121 , 1216\u00b12 cm \u22121 , 1174\u00b12 cm \u22121 , 1047\u00b12 cm \u22121 , 813\u00b12 cm \u22121 , 730\u00b12 cm \u22121 , 690\u00b12 cm \u22121 , 641\u00b12 cm \u22121 ; and/or \n (7) the IR pattern of the crystal form B includes the following characteristic absorption peaks expressed by the wavelength \u03bb: 3404\u00b12 cm \u22121 , 2954\u00b12 cm \u22121 , 2222\u00b12 cm \u22121 , 1718\u00b12 cm \u22121 , 1678\u00b12 cm \u22121 , 1558\u00b12 cm \u22121 , 1531\u00b12 cm \u22121 , 1369\u00b12 cm \u22121 , 1290\u00b12 cm \u22121 , 1219\u00b12 cm \u22121 , 1063\u00b12 cm \u22121 , 862\u00b12 cm \u22121 , 775\u00b12 cm \u22121 .

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 1.63934
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16087318', '15549918', '15329813', '12870507', '15772946']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7351850064844605
- 35 USC 102 Novelty (BERT): 0.534267647192995
- Combined Prediction Score: 0.715093270555314
- Mean Citation Score: 247.14044600000005
- Max Citation Score: 348.92108
- Similarity Product: 282.4506294654441

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test