PATENT CLAIM ANALYSIS

Application Number: 16124974
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["544", "364000"]

Abstract:
A compound having formula IA is useful for treating a neurodegenerative disease: or a pharmaceutically acceptable salt or ester thereof, where R 0 , R 1 , R 2 , R 7 , R 8  are delineated substituents; A 1  is a C 6-12  aryl group, C 5-12  heteroaryl group, substituted 3-hydroxypyridin-4(1H)-one, with i hydrogen atoms replaced with R 7  and j hydrogen atoms replaced with R 8 ; p is an integer from 1 to 6; X 1 , Y 1  are each independently CH or N; M is absent or a divalent linking moiety in which Z is repeated m times; m is an integer from 0 to 5; i, j are each independently 0, 1, 2, or 3; and o is 0, 1, 2, 3, or 4.

Claim (Index 1):
A compound having formula I for treating a neurodegenerative and other related CNS diseases: or a pharmaceutically acceptable salt or ester thereof, wherein\n R 0  is an optionally substituted C 1-8  alkyl, C 1-8  alkoxyl, C 2-8  alkenyl, C 2-8  alkynyl, C 4-8  cycloalkyl, C 4-8  cycloalkenyl, C 6-10  aryl, \n R 1  is an optionally substituted C 1-8  alkyl, C 1-8  alkoxyl, C 2-8  alkenyl, C 2-8  alkynyl, C 4-8  cycloalkyl, C 4-8  cycloalkenyl, or C 6-10  aryl; R 2  are hydroxyl, C 1-4  alkyl, C 1-4  alkoxyl, C 1-8  alkyl, C 2-8  alkenyl, C 2-8  alkynyl, C 4-8  cycloalkyl, C 4-8  cycloalkenyl; C 6-10  aryl, \u2014NR 3 q  or C 1-10  hydrocarbon groups optionally containing one or more O, N, S, or Se heteroatoms where R 3  individually are H or organyl groups and q is 2 or 3, with the proviso that when q is 3, the group bears a positive formal charge; R 7 , R 8  are each independently, H, hydroxyl, oxo, C 1-8  alkyl, C 1-8  alkoxyl, C 2-8  alkenyl, C 2-10  alkynyl, C 5-7  cycloalkyl, C 5-7  cycloalkenyl, halo, C 1-4  aldehyde, or \u2014NR 4 q  where R 4  is H, C 1-8  alkyl, C 2-8  alkenyl, C 4-8  cycloalkyl, C 4-8  cycloalkenyl, or C 6-10  aryl; A 1  is a C 6-12  aryl group, C 5-12  heteroaryl group, substituted 3-hydroxypyridin-4(1H)-one, with i hydrogen atoms replaced with R 7  and j hydrogen atoms replaced with R 8 ;\n p is an integer from 1 to 6; \n X 1 , Y 1  are each independently CH or N; \n Z m  is absent or a divalent linking moiety in which Z is repeated m times; \n m is an integer from 0 to 5; \n i, j are each independently 0, 1, 2, or 3; and \n o is 0, 1, 2, 3, or 4.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 97.0
- Lexical Diversity: 1.97436
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14648413', '13264505', '15187656', '14580045', '12588883']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8200459085908819
- 35 USC 102 Novelty (BERT): 0.5784057371875022
- Combined Prediction Score: 0.7958818914505439
- Mean Citation Score: 378.093878
- Max Citation Score: 488.865
- Similarity Product: 428.87492402851575

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test