PATENT CLAIM ANALYSIS

Application Number: 16014878
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-05
Patent Classification: ["435", "007100"]

Abstract:
The present invention relates to a piezoelectric mechanical system (PEMS) microcantilever sensor that both detects the presence of viral RNA in an aqueous solution, such as a blood sample. The method provides for the formation of the sensor by attaching RNA, DNA, or an antibody to the microcantilever sensor surface via a hydrazone or an oxime chemical bond. The method provides for the detection of viral RNA viruses and viral DNA viruses upon the chemical binding/bonding of single-stranded viral nucleic acid to the microcantilever sensor surface. The method provides for the detection of DNA cancer mutations or variants that have been identified in a cancer cell upon the chemical binding/bonding of single-stranded DNA to the microcantilever sensor surface.

Claim (Index 5):
A method of attaching a cfDNA sequence to a piezoelectric microcantilever sensor, the method comprising:\n oxidizing a cfDNA sequence that is an anti-sense compliment to a cfDNA sequence to be detected in an aqueous sample to result in the formation of at least one aldehyde functional group or at least one ketone functional group at the 3\u2032 terminus of the cfDNA sequence, creating a hydrazide functional group on a surface of the piezoelectric microcantilever sensor; bonding the 3\u2032 terminus of the cfDNA sequence to the hydrazide functional group on the surface of the piezoelectric microcantilever sensor; wherein a hydrazone bond is formed between an oxidized carbon atom of the at least one aldehyde functional group or at least one ketone functional group at the 3\u2032 terminus of the cfDNA sequence and a nitrogen atom of the hydrazide functional group on the surface of the piezoelectric microcantilever sensor; and\n wherein the surface of the piezoelectric microcantilever sensor is composed of silicon or silicon nitride, wherein the silicon or silicon nitride surface of the piezoelectric microcantilever sensor has been modified prior to creating the hydrazide functional group on the surface of the piezoelectric microcantilever sensor so that the piezoelectric microcantilever sensor surface includes at least one nitrogen atom that has been bonded to the silicon or silicon nitride surface of the piezoelectric microcantilever sensor.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 94.0
- Lexical Diversity: 2.04839
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12514941', '14551710', '11946534', '13160304', '12900160']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5728799607671653
- 35 USC 102 Novelty (BERT): 0.498270795722997
- Combined Prediction Score: 0.5654190442627485
- Mean Citation Score: 210.6505
- Max Citation Score: 230.83936
- Similarity Product: 150.16078342435836

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test