PATENT CLAIM ANALYSIS

Application Number: 15892921
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["424", "181100"]

Abstract:
Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the antibody-drug conjugates provided herein.

Claim (Index 212):
A composition comprising multiple copies of an antibody-drug conjugate of Formula (I):\n Ab-(L-D) p \u2003\u2003(I) wherein\n Ab is an internalizing anti-folate receptor alpha antibody or internalizing antigen-binding fragment thereof comprising three heavy chain complementarity determining regions (HCDRs) comprising amino acid sequences of SEQ ID NO:2 (HCDR1), SEQ ID NO:3 (HCDR2), and SEQ ID NO:4 (HCDR3); and three light chain complementarity determining regions (LCDRs) comprising amino acid sequences of SEQ ID NO:7 (LCDR1), SEQ ID NO:8 (LCDR2), and SEQ ID NO:9 (LCDR3), as defined by the Kabat numbering system; or three heavy chain complementarity determining regions (HCDRs) comprising amino acid sequences of SEQ ID NO:13 (HCDR1), SEQ ID NO:14 (HCDR2), and SEQ ID NO:15 (HCDR3); and three light chain complementarity determining regions (LCDRs) comprising amino acid sequences of SEQ ID NO:16 (LCDR1), SEQ ID NO:17 (LCDR2), and SEQ ID NO:18 (LCDR3), as defined by the IMGT numbering system; \n D is eribulin; \n L is a cleavable linker comprising Mal-(PEG) 2 -Val-Cit-pAB; and \n p is the average number of -L-D moieties per Ab, wherein the average p of the antibody-drug conjugates in the composition is from about 3.6 to about 4.4; and the average p is determined by hydrophobic interaction chromatography-high performance liquid chromatography (HIC-HPLC).

Metadata:
- Claim Count in Document: 31.0
- Percentile: 88.0
- Lexical Diversity: 1.25926
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15448497', '14205915', '15284444', '14204023', '14774512']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7425747052948647
- 35 USC 102 Novelty (BERT): 0.7623677834631163
- Combined Prediction Score: 0.7445540131116898
- Mean Citation Score: 509.29023000000007
- Max Citation Score: 1018.4353
- Similarity Product: 911.2045551898718

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test