PATENT CLAIM ANALYSIS

Application Number: 16106997
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["514", "04400A"]

Abstract:
The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides small interfering RNAs (siRNAs) having modification that enhance the stability of the siRNA without a concomitant loss in the ability of the siRNA to participate in RNA interference (RNAi). The invention also provides siRNAs having modification that increase targeting efficiency. Modifications include chemical crosslinking between the two complementary strands of an siRNA and chemical modification of a 3′ terminus of a strand of an siRNA. Preferred modifications are internal modifications, for example, sugar modification, nucleobase modification and/or backbone modifications. Such modifications are also useful, e.g., to improve uptake of the siRNA by a cell. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.

Claim (Index 69):
An siRNA derivative comprising an siRNA having two complementary strands of nucleic acid, wherein the two strands are crosslinked, a 3\u2032 OH terminus of one of the strands is modified, or the two strands are crosslinked and modified at the 3\u2032OH terminus, wherein the siRNA derivative\n (a) contains a single crosslink, \n (b) is psoralen crosslinked, \n (c) comprises a biotin at a 3\u2032 terminus, \n (d) comprises a photocleavable biotin having the structure depicted in  FIG. 20  at a 3\u2032 terminus, \n (e) comprises a peptide at a 3\u2032 terminus, \n (f) comprises a nanoparticle, peptidomimetic, or dendrimer at a 3\u2032 terminus, or \n (g) comprises a Tat peptide at the 3\u2032 terminus.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 96.0
- Lexical Diversity: 1.88158
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14661810', '13561357', '14294817', '13654199', '10912440']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8268394669841929
- 35 USC 102 Novelty (BERT): 0.6665384773169764
- Combined Prediction Score: 0.8108093680174713
- Mean Citation Score: 575.40515
- Max Citation Score: 810.7073
- Similarity Product: 618.0431152086676

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test