PATENT CLAIM ANALYSIS

Application Number: 16042206
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "210000"]

Abstract:
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Claim (Index 66):
A method of sensitizing a cell to an agent that induces a DNA lesion comprising the step of contacting the cell with a compound having the formula: wherein\n X is N, CR A5 ; \n R A1  is F, C 1-4 alkyl, C 3-5 cycloalkyl, OC 1-4 alkyl, OC 1-4 alkyl-C 3-5 cycloalkyl, NH 2 , NHC 1-4 alkyl, NHC 1-4 alkyl-C 3-5 cycloalkyl, or C 0-4 alkyl-heterocyclyl, wherein said heterocyclic ring system is selected from oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or morpholinyl, and each of said alkyl, cycloalkyl, or heterocyclyl is optionally substituted with up to three F atoms, up to three  2 H atoms, up to two non-geminal OH groups, or up to two OC 1-2 alkyl; \n each R A4  is, independently, H or  2 H; \n R A5  is hydrogen, F, C 1-4 alkyl, or OC 1-4 alkyl, wherein each of said alkyl is optionally substituted with up to three F atoms or up to three  2 H atoms; \n R B3  is C(O)NHC 1-4  alkyl, wherein said alkyl is optionally substituted with up to three F atoms, up to three  2 H atoms, up to two non-geminal OH groups, or up to two OC 1-2 alkyl; and \n each R B4  is, independently, hydrogen, deuterium, F, or C 1-4 alkyl.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 95.0
- Lexical Diversity: 1.29032
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14515793', '15912074', '15426150', '14205508', '14205657']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8273891356874714
- 35 USC 102 Novelty (BERT): 0.5743795086407574
- Combined Prediction Score: 0.8020881729828001
- Mean Citation Score: 415.617586
- Max Citation Score: 484.16336
- Similarity Product: 359.58794499465944

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test