PATENT CLAIM ANALYSIS

Application Number: 16080068
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "359000"]

Abstract:
The present invention provides the use of compounds which selectively block the Nav1.1 subtype of voltage-gated sodium (Nav) channels, whose role in nociception and pain has been unexplored. The present invention demonstrates that Nav1.1-expressing fibers are modality specific nociceptors: their activation elicits robust pain behaviors without neurogenic inflammation and produces profound hypersensitivity to mechanical, but not thermal, stimuli. In the gut, high-threshold mechanosensitive fibers also express Nav1.1 and show enhanced toxin sensitivity in a model of irritable bowel syndrome. The present invention provides an unexpected role for Nav1.1 in regulating the excitability of sensory nerve fibers that underlie mechanical pain, and provides methods of screening for other peptides and small molecules that can modulate Nav1.1 channels and their use in treatment of neurological disorders.

Claim (Index 22):
A method for inhibition of splanchnic colonic afferent neurons of a subject suffering from Irritable Bowel Syndrome (IBS), comprising administering to the subject, an effective amount of a composition comprising one or more Na v 1.1 channel blockers of formula I: or a salt, solvate, or stereoisomer thereof, wherein X is H, or one or more electron withdrawing groups such as a halogen, NH 2 , NO 2 , SO 2 , CN, or a C 1 -C 6  alkyl group; Alk is C 1 -C 3  alkyl; R 1  is H, C 1 -C 6  alkyl, which may be substituted with OH, NH 2 , alkylamino, amido, acyl, sulfonyl, sulfonylamino, and cyano groups; and R 2 , is C 1 -C 6  alkyl, alkenyl, and phenyl, which may be substituted with one or more OH, NH 2 , alkylamino, amido, acyl, carboxyl, methoxyl, sulfonyl, and cyano groups.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 96.0
- Lexical Diversity: 1.51111
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12930978', '13507928', '11155262', '11749814', '10071380']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7316011295335038
- 35 USC 102 Novelty (BERT): 0.5000678337344266
- Combined Prediction Score: 0.7084477999535961
- Mean Citation Score: 174.12164
- Max Citation Score: 185.72151
- Similarity Product: 110.97636707084656

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test