PATENT CLAIM ANALYSIS

Application Number: 16118760
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["546", "119000"]

Abstract:
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

Claim (Index 1):
A compound having the structure of Formula I: or a pharmaceutically acceptable salt thereof, wherein W 1  and W are each independently selected from N, NR a , and CR a , wherein one of W 1  and W is NR a ; X is N or CR b ; Y is selected from a bond, \u2014C(O)\u2014, and \u2014SO 2 \u2014; Z is selected from \u2014(CR 5 R 6 ) m \u2014, \u2014(CR 5 R 6 ) m O\u2014, \u2014(CR 5 R 6 ) m CR 5 \u2550CR 5 \u2014, \u2014(CR 5 R 6 ) m \u2014C 3 -C 6 -cycloalkylene-, and \u2014(CR 5 R 6 ) m \u2014NR 7 \u2014; R 1  is selected from C 3 -C 8 -cycloalkyl, C 2 -C 8 -heterocyclyl, \u2014OR c , C 1 -C 6 -alkyl, halo, and C 2 -C 8 -alkenyl, wherein alkyl, cycloalkyl, heterocyclyl, and alkenyl are optionally substituted with 1, 2, 3, or 4 groups each independently selected from \u2014OH, halo, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, \u2014O\u2014C 1 -C 6 -alkyl, and C 1 -C 6 -alkyl-OH; R 2  is, at each occurrence, independently selected from H, \u2014OH, halo, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, \u2014O\u2014C 1 -C 6 -alkyl, and C 1 -C 6 -alkyl-OH; R 3  is, at each occurrence, selected from H, \u2014OH, halo, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, \u2014O\u2014C 1 -C 6 -alkyl, and C 1 -C 6 -alkyl-OH; R 4  is selected from C 1 -C 6 -alkyl, (CR 8 R 9 ) p \u2014C 3 -C 8 -cycloalkyl, (CR 8 R 9 ) p \u2014C 2 -C 8 -heterocyclyl, (CR 8 R 9 ) p \u2014C 1 -C 9 -heteroaryl, and (CR 8 R 9 ) p \u2014C 6 -C 12 -aryl, wherein alkyl, cycloalkyl, heterocyclyl, heteroaryl, and aryl are optionally substituted with 1, 2, 3, or 4 groups, each independently selected from \u2014OH, halo, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, \u2014O\u2014C 1 -C 6 -alkyl, C(O)N(R f ) 2 , C(O)OR f , \u2014OCH 2 C(O)OR f , \u2014SO 2 R f , and C 1 -C 6 -alkyl-OH; R 5  is, at each occurrence, independently selected from H, \u2014OH, halo, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, \u2014O\u2014C 1 -C 6 -alkyl, and C 1 -C 6 -alkyl-OH; alternatively, R 4  and R 5  are optionally joined to form a heterocyclic ring; R 6  is, at each occurrence, independently selected from H, \u2014OH, halo, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, \u2014O\u2014C 1 -C 6 -alkyl, and C 1 -C 6 -alkyl-OH; R 7  is selected from H, C 1 -C 6 -alkyl, and C 1 -C 6 -alkyl-OH; R 8  is, at each occurrence, independently selected from H, \u2014OH, halo, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, \u2014O\u2014C 1 -C 6 -alkyl, and C 1 -C 6 -alkyl-OH; R 9  is, at each occurrence, independently selected from H, \u2014OH, halo, C 1 -C 6 -haloalkyl, \u2014O\u2014C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-OH, and C 1 -C 6 -alkyl; R a  is selected from H, C 1 -C 6 -alkyl, and C 1 -C 6 -alkyl-OH; R b  is selected from H and C 1 -C 6 -alkyl; R c  is selected from H, C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-OH, C 3 -C 8 -cycloalkyl, C 2 -C 8 -heterocyclyl, C 6 -C 12 -aryl, and C 1 -C 9 -heteroaryl; R f  is, at each occurrence, independently selected from H and C 1 -C 6 -alkyl; m is 0, 1, 2, 3, or 4; n is 0, 1, 2, or 3; and p is 0, 1, 2, 3, or 4.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 96.0
- Lexical Diversity: 1.42308
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14984325', '15843598', '14984293', '15347468', '14984654']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8782567573866841
- 35 USC 102 Novelty (BERT): 0.6311898608183633
- Combined Prediction Score: 0.853550067729852
- Mean Citation Score: 697.37725
- Max Citation Score: 724.7858
- Similarity Product: 537.181145776558

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test