PATENT CLAIM ANALYSIS

Application Number: 15764309
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-02
Patent Classification: ["548", "178000"]

Abstract:
Provided is a method for producing flutemetamol including the steps of: reacting a precursor compound represented by a predetermined general formula with a radioactive fluoride to obtain a  18 F labeling compound represented by a predetermined general formula; allowing a strong base to act on the reaction mixture of the above step containing the precursor compound and the  18 F labeling compound; after the above step, purifying the  18 F labeling compound using a reverse phase solid phase extraction cartridge; and removing a protective group to obtain [ 18 F]flutemetamol.

Claim (Index 9):
A method for producing flutemetamol comprising the steps of:\n (a) reacting a compound represented by the following general formula (1) with a radioactive fluoride to obtain a compound represented by the following general formula (2), wherein the group \u2014OR 1  is an ethoxymethoxy group or a methoxymethoxy group, and the group R 2  is hydrogen or an alkyl having 1 to 10 carbon atoms; (b) allowing a strong base to act on the reaction mixture of the step (a) containing the compound represented by the general formula (1) and the compound represented by the general formula (2) to form a decomposition mixture; (c) purifying the decomposition mixture of step (b) to obtain the compound represented by the general formula (2) using a reverse phase solid phase extraction cartridge; (d) removing a protective group of the compound represented by the general formula (2) to obtain [ 18 F]flutemetamol; (e) purifying the [ 18 F]flutemetamol of step (d) using a reverse phase solid phase extraction cartridge to obtain [ 18 F]flutemetamol purified after the first purification; and (f) further purifying the [ 18 F]flutemetamol after the first purification of step (e) using a hydrophilic interaction solid phase extraction cartridge.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 90.0
- Lexical Diversity: 1.78182
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13517276', '14619871', '15524705', '15254090', '12227240']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7133451508564881
- 35 USC 102 Novelty (BERT): 0.4869298030895403
- Combined Prediction Score: 0.6907036160797934
- Mean Citation Score: 197.81632800000003
- Max Citation Score: 228.03844
- Similarity Product: 175.03932984135628

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test