PATENT CLAIM ANALYSIS

Application Number: 16045855
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-05
Patent Classification: ["514", "054000"]

Abstract:
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.

Claim (Index 43):
A compound for use in the treatment of prostate cancer in a patient according to the chemical structure: wherein A is an antibody binding moiety comprising a hapten which is capable of binding to an endogenous pre-existing antibody in a patient which is not raised as part of a treatment regimen; B is a cell binding moiety according to the chemical formula: Where X 1  and X 2  are each independently CH 2 , O, NH or S; X 3  is O, CH 2 , NR 1 , S(O), S(O) 2 , \u2014S(O) 2 O, \u2014OS(O) 2 , or OS(O) 2 O; R 1  is H, a C 1 -C 3  alkyl group, or a \u2014C(O)(C 1 -C 3 ) group; k is an integer from 1 to 15; L is a linker according to the chemical formula: Or L is a polyethylene gycol, polypropylene glycol or polypropylene-co-polyethylene glycol linker having between 1 and 20 glycol units; Where R a  is H, C 1 -C 3  alkyl or alkanol or forms a proline side chain with R 3 ; R 3  forms a proline side chain with R a  or is a side chain derived from an amino acid selected from the group consisting of alanine, arginine, asparagine, aspartic acied, cysteine, glutamine, glutamic acid, glycine, histicine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan and valine; and m is an integer from 1 to 30; or L is a linker according to the chemical formula: Where Z and Z\u2032 are each independently a bond, \u2014(CH 2 ) i \u2014O, \u2014(CH 2 ) i \u2014S, \u2014(CH 2 ) i \u2014N\u2014R, wherein said \u2014(CH 2 ) i  group, if present in Z or Z\u2032, is bonded to [CON] if present, antibody binding terminus (ABT) or cell binding terminus (CBT); Each R is independently H, or a C 1 -C 3  alkyl or alkanol group; Each R 2  is independently H or a C 1 -C 3  alkyl group; Each Y is independently a bond, O, S or N\u2014R; Each i is independently 0 to 100; D is or a bond,\n with the proviso that Z, Z\u2032 and D are not each simultaneously bonds; \n j is 1 to 100; \n m\u2032 is 1 to 100; \n n\u2032 is 1 to 100; and \n X 1  is 0, S or N\u2014R, \n R is as defined above; and \n [CON] is a bond or a moiety according to the chemical structure: \n Where X 2  is O, S, NR 4 , S(O), S(O) 2 , \u2014S(O) 2 O, \u2014OS(O) 2 , or OS(O) 2 O; X 3  is NR 4 , O or S; and R 4  is H, a C 1 -C 3  alkyl or alkanol group, or a \u2014C(O)(C 1 -C 3 ) group; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 95.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14480204', '15083025', '13173480', '12991926', '14397995']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7722833380626745
- 35 USC 102 Novelty (BERT): 0.5629445014867881
- Combined Prediction Score: 0.7513494544050858
- Mean Citation Score: 397.042508
- Max Citation Score: 436.78046
- Similarity Product: 355.8791747740591

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test