PATENT CLAIM ANALYSIS

Application Number: 16119501
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["424", "186100"]

Abstract:
Described herein is the generation of optimized HIN1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2011. Provided herein are optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.

Claim (Index 13):
A fusion protein comprising an influenza hemagglutinin (HA) polypeptide and a heterologous protein, wherein the amino acid sequence of the HA polypeptide comprises:\n (i) no more than 5 amino acid substitutions relative to SEQ ID NO: 1; (ii) SEQ ID NO: 2; (iii) no more than 6 amino acid substitutions relative to SEQ ID NO: 3; (iv) no more than 8 amino acid substitutions relative to SEQ ID NO: 4; (v) no more than 10 amino acid substitutions relative to SEQ ID NO: 5; (vi) no more than 8 amino acid substitutions relative to SEQ ID NO: 6; (vii) no more than 10 amino acid substitutions relative to SEQ ID NO: 7; (viii) no more than 10 amino acid substitutions relative to SEQ ID NO: 8; (ix) SEQ ID NO: 9; (x) no more than 8 amino acid substitutions relative to SEQ ID NO: 10; or (xi) no more than 5 amino acid substitutions relative to SEQ ID NO: 11.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 96.0
- Lexical Diversity: 1.65625
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14126550', '15392710', '15051991', '14092371', '15407502']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7704918180765463
- 35 USC 102 Novelty (BERT): 0.6000358292401582
- Combined Prediction Score: 0.7534462191929076
- Mean Citation Score: 500.358418
- Max Citation Score: 510.4525
- Similarity Product: 482.7177945747972

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test