PATENT CLAIM ANALYSIS

Application Number: 16228546
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "261100"]

Abstract:
The invention relates to a compound of formula (I) wherein R 1  to R 4  are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Claim (Index 9):
The compound according to  claim 1  selected from the group consisting of:\n 5-tert-butyl-2-({2-chloro-4-[3-(trifluoromethyl)-3H-diaziren-3-yl]phenyl}methyl)-7-(3,3-difluoropyrrolidin-1-yl)-2H-[1,2,3]triazolo[4, 5-d]pyrimidine; \n 4-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-2H-[1,2,3]triazolo[4, 5-d]pyrimidin-2-yl]methyl}-N-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethyl}-1,2,5-oxadiazole-3-carboxamide; \n 4-({5-tert-butyl-7-[(3S)-3-hydroxypyrrolidin-1-yl]-2H-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl}methyl)-N-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethyl}-1,2, 5-oxadiazole-3-carboxamide; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-2-({2-[3-(trifluoromethyl)-3H-diaziren-3-yl]phenyl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-2-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3S)-1-[5-tert-butyl-2-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-2-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3S)-1-{5-[difluoro(phenyl)methyl]-2-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-2H-[1,2,3]triazolo[4, 5-d]pyrimidin-7-yl}pyrrolidin-3-ol; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-2-({4-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-3-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3S)-1-[5-tert-butyl-2-({4-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-3-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-2-({4-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-3-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3S)-1-{5-[difluoro(phenyl)methyl]-2-({4-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-3-yl}methyl)-2H-[1,2,3]triazolo[4, 5-d]pyrimidin-7-yl}pyrrolidin-3-ol; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-2-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyrimidin-4-yl}methyl)-2H-[1,2,3]triazolo[4, 5-d]pyrimidine; \n (3S)-1-[5-tert-butyl-2-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyrimidin-4-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-2-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyrimidin-4-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3S)-1-{5-[difluoro(phenyl)methyl]-2-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyrimidin-4-yl}methyl)-2H-[1,2,3]triazolo[4, 5-d]pyrimidin-7-yl}pyrrolidin-3-ol; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-2-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-4-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3S)-1-[5-tert-butyl-2-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-4-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-2-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-4-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3S)-1-{5-[difluoro(phenyl)methyl]-2-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-4-yl}methyl)-2H-[1,2,3]triazolo[4, 5-d]pyrimidin-7-yl}pyrrolidin-3-ol; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-2-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-2-phenyl-]methyl]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-2-[[2-ethynyl-6-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methyl]triazolo[4,5-d]pyrimidine; \n (3S)-1-[5-tert-butyl-2-[[2-ethynyl-6-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; and \n (3S)-1-[5-[difluoro(phenyl)methyl]-2-[[2-ethynyl-6-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 98.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16228535', '16228539', '13669610', '16228543', '14250781']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8377100390250368
- 35 USC 102 Novelty (BERT): 0.6716337428307488
- Combined Prediction Score: 0.821102409405608
- Mean Citation Score: 548.20635
- Max Citation Score: 693.279
- Similarity Product: 635.74382355237

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test