PATENT CLAIM ANALYSIS

Application Number: 15990576
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "230500"]

Abstract:
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

Claim (Index 19):
A compound, or a pharmaceutically acceptable salt thereof, having the structure of Formula (XV): wherein, Ring B is an optionally substituted 5-membered heteroaryl ring containing at least one oxygen or sulfur atom; R 2  is selected from CH 3 , CH 2 CH 3 , CH 2 CF 3 , CH 2 F, CHF 2 , CF 3 , CH 2 D, CHD 2 , or CD 3 ; X1 is C\u2014H or N; R A  is X2 is N or C\u2014R 12 , wherein R 12  is hydrogen, halogen, alkyl, or alkoxy; R 13  is \u2014Y\u2014Z; Y is selected from a bond, \u2014CH 2 \u2014, or \u2014CH(C 1 -C 4  alkyl)-; Z is selected from \u2014SO 2 R 21 , \u2014N(R 22 )SO 2 R 21 , \u2014SO 2 N(R 22 ) 2 , \u2014N(R 22 )SO 2 N(R 22 ) 2 , \u2014CON(R 22 ) 2 , \u2014N(R 22 )CO 2 R 21 , \u2014N(R 22 )CON(R 22 ) 2 , \u2014N(R 22 )COR 21 , \u2014OC(O)N(R 22 ) 2 , \u2014OSO 2 N(R 22 ) 2 , or \u2014N(R 22 )SO 3 R 21 ; X3 is N or C\u2014R 14 , wherein R 14  is hydrogen, halogen, \u2014CN, alkyl, cycloalkyl, or alkoxy; or optionally when X4 is C\u2014R 15 , R 14  and R 15  connect to form a ring; X4 is N or C\u2014R 15 , wherein R 15  is hydrogen, halogen, \u2014CN, alkyl, or alkoxy; R 16  is hydrogen, halogen, or \u2014W\u2014X, wherein W is a bond, \u2014O\u2014, \u2014S\u2014, or \u2014NH\u2014, and X is selected from alkyl, alkynyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkynyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; or optionally when X4 is C\u2014R 15 , R 16  and R 15  connect to form a ring; each R 21  is independently selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and each R 22  is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.425
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14517705', '15870557', '14789881', '14658048', '15488674']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8427046287751276
- 35 USC 102 Novelty (BERT): 0.6061507845818592
- Combined Prediction Score: 0.8190492443558008
- Mean Citation Score: 497.6735259999999
- Max Citation Score: 580.4232
- Similarity Product: 468.8200530299663

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test