PATENT CLAIM ANALYSIS

Application Number: 15761725
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["514", "017800"]

Abstract:
The present invention relates to an agent which inhibits Kallikrein-8 for use in the treatment or prevention of Alzheimer's disease and/or its precursor stages, as well as to methods, kits and uses relating thereto, including diagnostic tools.

Claim (Index 13):
An in vitro method of predicting and/or diagnosing Alzheimer's disease and/or a precursor stage of Alzheimer's disease,\n comprising the steps of: (1) detecting the level of Kallikrein-8 protein and/or kallikrein-8 mRNA in a bodily sample of an individual exhibiting cognitive impairment, and (2) comparing the level determined in step (1) with the level(s) determined in one or more reference samples from healthy individuals and/or from patients known to exhibit Alzheimer's disease and/or a precursor stage of Alzheimer's disease, wherein an increased level determined in step (1) compared to the level(s) determined in one or more reference samples from healthy individuals, and/or a level determined in step (1) which is identical or similar to the level(s) determined in one or more reference samples from patients known to have Alzheimer's disease and/or a precursor stage of Alzheimer's disease indicates that (i) the individual has Alzheimer's disease and/or a precursor stage of Alzheimer's disease, and/or (ii) the individual has a high risk of developing Alzheimer's disease and/or for a precursor stage of Alzheimer's disease. preferably wherein the individual was not yet diagnosed to exhibit Alzheimer's disease and/or a precursor stage of Alzheimer's disease, more preferably wherein the bodily sample is selected from a bodily fluid sample, in particular selected from cerebrospinal fluid sample, blood sample, such as plasma sample, whole blood sample and serum sample, urine sample and saliva sample, and a biopsy, in particular a brain tissue biopsy, even more preferably the bodily fluid sample is a cerebrospinal fluid sample.

Metadata:
- Claim Count in Document: 21.0
- Percentile: 90.0
- Lexical Diversity: 1.10526
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12157664', '13393220', '14324289', '13701758', '11185907']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7566286639252039
- 35 USC 102 Novelty (BERT): 0.5221262623003475
- Combined Prediction Score: 0.7331784237627182
- Mean Citation Score: 308.592442
- Max Citation Score: 328.3323
- Similarity Product: 235.03792800296543

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test