PATENT CLAIM ANALYSIS

Application Number: 15879999
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-10
Patent Classification: ["514", "210210"]

Abstract:
The present application is concerned with heterocyclic compounds that inhibit the activity of Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancers and other diseases.

Claim (Index 36):
A method of treating an immune disorder comprising administering to a patient in need thereof a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or a stereoisomer thereof, wherein: R 1  is selected from H, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  halaolkyl, C 1-6  haloalkoxy, C 6-10  aryl, C 3-10  cycloalkyl, 5-14 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-14 membered heteroaryl)-C 1-4  alkyl-, (4-10 membered heterocycloalkyl)-C 1-4  alkyl-, CN, NO 2 , OR a , SR a , NHOR a , C(O)R a , C(O)NR a R a , C(O)OR a , OC(O)R a , OC(O)NR a R a , NHR a , NR a R a , NR a C(O)R a , NR a C(O)OR a , NR a C(O)NR a R a , C(\u2550NR a )R a , C(\u2550NR a )NR a R a , NR a C(\u2550NR a )NR a R a , NR a S(O)R a , NR a S(O) 2 R a , NR a S(O) 2 NR a ,R a , S(O)R a , S(O)NR a R a , S(O) 2 R a , and S(O) 2 NR a R a , wherein the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-14 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-14 membered heteroaryl)-C 1-4  alkyl-, and (4-10 membered heterocycloalkyl)-C 1-4  alkyl- of R 1  are each optionally substituted with 1, 2, 3, or 4 R b  substituents, each R b  substituent is independently selected from halo, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  haloalkoxy, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl, C 3-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl-, (4-10 membered heterocycloalkyl)-C 1-4  alkyl-, CN, OH, NH 2 , NO 2 , NHOR c , OR c , SR c , C(O)R c , C(O)NR c R c , C(O)OR c , OC(O)NR c R c , OC(O)NR c R c , C(\u2550NR c )NR c R c , NR c C(\u2550NR c )NR c R c , NHR c , NR c R c , NR c C(O)R c , NR c C(O)OR c , NR c C(O)NR c R c , NR c S(O)R c , NR c S(O) 2 R c , NR c S(O) 2 NR c R c , S(O)R c , S(O)NR c R c , S(O) 2 R c  and S(O) 2 NR c R c ; wherein the C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  haloalkoxy, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl-, and (4-10 membered heterocycloalkyl)-C 1-4  alkyl- of R b  are each optionally substituted with 1-3 independently selected R d  substituents; or two adjacent R b  substituents on the C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl ring of R 1 , taken together with the atoms to which they are attached, form a fused phenyl ring, a fused 5- or 6-membered heterocycloalkyl ring, a fused 5- or 6-membered heteroaryl ring, or a fused C 5-6  cycloalkyl ring, wherein the fused 5- or 6-membered heterocycloalkyl ring and fused 5- or 6-membered heteroaryl ring each have 1-4 heteroatoms as ring members selected from N, O and S and wherein the fused phenyl ring, fused 5- or 6-membered heterocycloalkyl ring, fused 5- or 6-membered heteroaryl ring, and fused C 5-6  cycloalkyl are each optionally substituted with 1 or 2 independently selected R r  substituents; each R a  is independently selected from H, CN, C 1-6  alkyl, C 1-4  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl-, and (4-10 membered heterocycloalkyl)-C 1-4  alkyl-, wherein the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl,4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl-, and (4-10 membered heterocycloalkyl)-C 1-4  alkyl- of R a  are each optionally substituted with 1, 2, 3, 4, or 5 R d  substituents; each R d  is independently selected from C 1-4  alkyl, C 1-4  haloalkyl, halo, C 3-10  cycloalkyl, 4-10 membered heterocycloalkyl, CN, NH 2 , NHOR e , OR e , SR e , C(O)R e , C(O)NR e R e , C(O)OR e , OC(O)R e , OC(O)NR e R e , NHR e , NR e R e , NR e C(O)R e , NR e C(O)NR e R e , NR e C(O)OR e , C(\u2550NR e )NR e R e , NR e C(\u2550NR e )NR e R e , S(O)R e , S(O)NR e R e , S(O) 2 R e , NR e S(O) 2 R e , NR e S(O) 2 NR e R e , and S(O) 2 NR e R e , wherein the C 1-4  alk y l, C 3-10  cycloalkyl and 4-10 membered heterocycloalkyl of R d  are each further optionally substituted with 1-3 independently selected R r  substituents; each R c  is independently selected from H, C 1-6  alkyl, C 1-4  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl-, and (4-10 membered heterocycloalkyl)-C 1-4  alkyl-, wherein the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-10  cycloalkyl,5-10 membered heteroaryl,4-10 membered heteroacycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl-, and (4-10 membered heterocycloalkyl)-C 1-4  alkyl- of R c  are each optionally substituted with 1, 2, 3, 4, or 5 R f  substituents independently selected from C 1-4  alkyl, C 1-4  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl,4-10 membered heteroacycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl-, (4-10 membered heterocycloalkyl)-C 1-4 alkyl-, halo, CN, NHOR g , OR g , SR g , C(O)R g , C(O)NR g R g , C(O)OR g , OC(O)R g , OC(O)NR g R g , NHR g , NR g R g , NR g C(O)R g , NR g C(O)NR g R g , NR g C(O)OR g , C(\u2550NR g )NR g R g , NR g C(\u2550NR g )NR g R g , S(O)R g , S(O)NR g R g , S(O) 2 R g , NR g S(O) 2 R g , NR g S(O) 2 NR g R g , and S(O) 2 NR g R g ; wherein the C 1-4  alkyl, C 1-4  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl-, and (4-10 membered heterocycloalkyl)-C 1-4  alkyl- of R f  are each optionally substituted with 1, 2, 3, 4, or 5 R n  substituents independently selected from C 1-4  alkyl, C 1-4  haloalkyl, halo, CN, R o , NHOR o , OR o , SR o , C(O)R o , C(O)NR o R o , C(O)OR o , OC(O)R o , OC(O)NR o R o , NHR o , NR o R o , NR o C(O)R o , NR o C(O)NR o R o , NR o C(O)OR o , C(\u2550NR o )NR o R o , NR o C(\u2550NR o )NR o R o , S(O)R o , S(O)NR o R o , S(O) 2 R o , NR o S(O) 2 R o , NR o S(O) 2 NR o R o , and S(O) 2 NR o R o ; each R g  is independently selected from H, C 1-6  alkyl, C 1-4  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl-, and (4-10 membered heterocycloalkyl)-C 1-4  alkyl-, wherein the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-10  cycloalkyl, 5-10 membered heteroaryl,4-10 membered heteroacycloalkyl, C 6-10  aryl, C 1-4  alkyl-, C 3-10  cycloalkyl-C 1-4  alkyl-, (5-10 membered heteroaryl)-C 1-4  alkyl- and (4-10 membered heterocycloalkyl)-C 1-4  alkyl- of Rg are each optionally substituted with 1-3 independently selected R p  substituents; or any two R a  substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7-, 8-, 9- or 10-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 R h  substituents independently selected from C 1-6  alkyl, C 3-10  cycloalkyl, 4-7 membered heterocycloalkyl, C 6-10  aryl, 5-6 membered heteroaryl, C 1-6  halaolkyl, C 2-6  alkenyl, C 2-6  alkynyl, halo, CN, OR i , SR i , NHOR i , C(O)NR i R i , C(O)NRilti, C(O)OR i , OC(O)R i , OC(O)NR i R i , NHR i , NR i R i , NR i C(O)R i , NR i C(O)NR i R i , NR i C(O)OR i , C(\u2550NR i )NR i R i , NR i C(\u2550NR i )NR i R i , S(O)R i , S(O)NR i R i , S(O) 2 R i , NR i SO 2 R i , NR i S(O) 2 NR i R i , and S(O) 2 NR i R i , wherein the C 1-6  alkyl, C 3-10  cycloalkyl, 4-7 membered heterocycloalkyl, C 6-10  aryl, and 5-6 membered heteroaryl of R h  are each further optionally substituted by 1, 2, or 3 substituents independently selected from C 3-6  cycloalkyl, C 6-10  aryl, 5- or 6-membered heteroaryl, C 1-4  alkenyl, C 2-4  alkynyl, halo, C 1-4  alkyl, C 1-4  haloalkyl, CN, NHOR k , OR k , SR k , C(O)R k , C(O)NR k R k , C(O)OR k , OC(O)R k , OC(O)NR k R k , NHR k , NR k R k , NR k C(O)R k , NR k C(O)NR k R k , NR k C(O)OR k , C(\u2550NR k )NR k R k , NR k C(\u2550NR k )NR k R k , S(O)R k , S(O)NR k R k , S(O) 2 R k , NR k S(O) 2 R k , NR k S(O) 2 NR k R k , and S(O) 2 NR k R k ; or two R h  groups attached to the same carbon atom of the 4- to 10-membered heterocycloalkyl taken together with the carbon atom to which they attach form a C 3-6  cycloalkyl or 4- to 6-membered heterocycloalkyl having 1-2 heteroatoms as ring members selected from O, N or S; or any two R c  substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected R h  substituents; or any two R e  substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected R h  substituents; or any two R g  substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected R h  substituents; or any two R i  substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected R h  substituents; or any two R k  substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected R h  substituents; or any two R o  substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected R h  substituents; and each R e , R i , R k , R o  or R p  is independently selected from H, C 1-4  alkyl, C 3-6  cycloalkyl, C 6-10  aryl, 5- or 6-membered heteroaryl, C 1-4  haloalkyl, C 1-4  alkenyl, and C 2-4  alkynyl, wherein the C 1-4  alkyl, C 3-6  cycloalkyl, C 6-10  aryl, 5- or 6-membered heteroaryl, C 1-4  alkenyl, and C 2-4  alkynyl of R e , R i , R k , R o  or R p  are each optionally substituted with 1, 2 or 3 R r  substituents; each R r  is independently selected from OH, CN, amino, halo, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  alkylthio, C 3-6  cycloalkyl, NHR 9 , NR 9 R 9 , and C 1-4  haloalkoxy, wherein the C 1-4  alkyl of R r  is optionally substituted with OH, CN, NH 2 , C 1-4  alkoxy, C 3-10  cycloalkyl, and 4-10 membered heterocycloalkyl, wherein each R 9  is independently H or C 1-6  alkyl; R 2  is H, OH, OR a , NHR a  or NR a R a ; R 3  is H, halo or CN; each R 4  is independently selected from H, halo, CN, OH, NH 2 , NHCH 3 , N(CH 3 ) 2 , C 1-4  alkyl, C 1-4 alkoxy, C 1-2 haloalkyl, C 1-2  halaolkoxy, ethenyl, C 2-4  alkynyl and cyclopropyl, wherein the C 1-4  alkyl and C 1-4  alkoxy are each optionally substituted with CN or CH 3 O\u2014; each R 5  is independently selected from H, halo, CN, OH, NH 2 , NHCH 3 , N(CH 3 ) 2 , C 1-4  alkyl, C 1-4 alkoxy, C 1-2  haloalkyl, C 1-2  haloalkoxy, ethenyl, C 2-4  alkynyl, C 3-6  cycloalkyl, C 6-10  aryl, and 5- or 6-membered heteroaryl, wherein the C 1-4  alkyl and C 1-4  alkoxy are each optionally substituted with CN or CH 3 O\u2014; each R 6  is independently selected from H, halo, CN, OH, NH 2 , NHCH 3 , N(CH 3 ) 2 , C 1-4  alkyl, C 1-4 alkoxy, C 1-2  qhaloalkoxy, ethenyl, C 2-4  alkynyl, C 3-6  cycloalkyl, C 6-10  aryl, and 5- or 6-membered heteroaryl, wherein the C 1-4  alkyl, C 1-4  alkoxy, C 3-6  cycloalkyl, C 6-10  aryl, and 5- or 6-membered heteroaryl are each optionally substituted with OH, CN or CH 3 O\u2014; or any two R 6  substituents attached to the same carbon atom, taken together with the carbon atom to which they are attached, form C 3-10  cycloalkyl or a 4-, 5-, or 6-membered heterocycloalkyl, wherein the C 3-10  cycloalkyl and 4-, 5-, or 6-membered heterocycloalkyl are each optionally substituted with 1-3 independently selected R p  substituents; R 8  is H, C 1-4  alkyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-4  alkyl-, wherein the C 1-4  alkyl, C 3-6  cycloalkyl and C 3-6  cycloalkyl-Ch4 alkyl are each optionally substituted with OH, CN or CH 3 O\u2014; X is N or CR 7 , wherein R 7  is H, halo, NH 2 , C 1-4  alkoxy, C 1-4  alkyl-NH\u2014 or (C 1-4  alkyl) 2 N\u2014; the subscript m is an integer of 1 or 2; the subscript n is an integer of 1, 2 or 3; and the subscript p is an integer of 1, 2 or 3.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 1.34483
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14465910', '15001826', '14155134', '14798137', '15166380']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8113328447428042
- 35 USC 102 Novelty (BERT): 0.5426208482236378
- Combined Prediction Score: 0.7844616450908877
- Mean Citation Score: 403.687508
- Max Citation Score: 408.53394
- Similarity Product: 293.4456372546029

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test