PATENT CLAIM ANALYSIS

Application Number: 16052510
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-07
Patent Classification: ["424", "450000"]

Abstract:
The invention discloses a method for the formation of liposomes by using high shear mixing of aqueous solution of lipid powder; the lipid powder can be produced by any known technique. Components of the liposomes include but are not limited to cationic lipids, immunostimulators/immunopotentiators and macromolecules as components for the liposome formation. The disclosed method describes the formulation of stable liposomes solitary or complexing high concentrations of macromolecules such as proteins, DNA and RNA having opposite charge of the liposomes by high shear mixing where aggregation is avoided due to the formulation method.

Claim (Index 1):
A method of producing liposomes using high shear mixing of a lipid powder where one lipid component is a quaternary ammonium compounds having the general formula NR 1 R 2 R 3 R 4 \u2014X wherein R 1  and R 2  independently each is a short chain alkyl group containing from 1 to 3 carbon atoms, R 3  is independently hydrogen or a methyl or an alkyl group containing from 12 to 20 carbon atoms, preferably 14 to 18 carbon atoms, and R 4  is independently a hydrocarbon group containing from 12 to 20 carbon atoms, preferably from 14 to 18 carbon atoms, and X is a pharmaceutical acceptable anion, which itself is nontoxic, is hydrated in an aqueous solution.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 96.0
- Lexical Diversity: 1.57143
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12784821', '11174955', '12666102', '13083385', '14216605']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7454092139848576
- 35 USC 102 Novelty (BERT): 0.5399682958464415
- Combined Prediction Score: 0.724865122171016
- Mean Citation Score: 283.39983399999994
- Max Citation Score: 370.0224
- Similarity Product: 265.69282104492186

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test