PATENT CLAIM ANALYSIS

Application Number: 16263512
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["546", "187000"]

Abstract:
This present disclosure is directed to compounds of formula (I): where R 1a , R 3 , Y, and Z are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A 4  hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions including the compounds described herein and methods of preparing the compounds described herein are also provided.

Claim (Index 1):
A compound having the following formula (I): wherein\n R 1a  is hydrogen, halo, haloalkyl, haloalkenyl, haloalkynyl, hydroxyalkyl, cyano, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted amidinyl, optionally substituted guanidinyl, \u2014R 13 \u2014OR 10 , \u2014R 13 \u2014C(\u2550O)OR 10 , or \u2014R 13 \u2014C(\u2550O)R 10 ; \n R 3  is a direct bond, \u2014O\u2014, \u2014R 12 \u2014O\u2014, \u2014O\u2014R 12 \u2014, \u2014O\u2014R 12 \u2014O\u2014, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain, or an optionally substituted straight or branched alkynylene chain, \u2014R 13 \u2014C(\u2550O)R 13 , \u2014O\u2014R 13 \u2014C(\u2550O)R 13 , \u2014R 13 \u2014O\u2014R 13 \u2014C(OH)\u2014R 13 , or \u2014NR 13 \u2014; Y is hydrogen, halo, haloalkyl, haloalkenyl, haloalkynyl, hydroxyalkyl, cyano, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heterocyclyl, or optionally substituted heterocyclylalkyl; and Z is each R 10  is independently hydrogen, haloalkyl, haloalkenyl, haloalkynyl, hydroxyalkyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heterocyclyl, or optionally substituted heterocyclylalkyl;\n each R 12  is independently an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain, or an optionally substituted straight or branched alkynylene chain; \n each R 13  is independently a direct bond, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain, or an optionally substituted straight or branched alkynylene chain; \n as a single stereoisomer or as a mixture of stereoisomers; or a pharmaceutically acceptable salt, ammonium ion, or N-oxide thereof.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 99.0
- Lexical Diversity: 1.45161
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15837515', '14313672', '11644244', '14849810', '15704199']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.79303165610362
- 35 USC 102 Novelty (BERT): 0.5831895698081437
- Combined Prediction Score: 0.7720474474740724
- Mean Citation Score: 384.863876
- Max Citation Score: 466.39145
- Similarity Product: 451.95104242277154

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test