PATENT CLAIM ANALYSIS

Application Number: 16161198
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "210000"]

Abstract:
The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

Claim (Index 1):
A method for treating a patient suffering from a disease or condition selected from cardiovascular disorders, respiratory disorders, metabolic disorders, skin disorders, bone disorders, neuroinflammatory and/or neurodegenerative disorders, kidney diseases, reproduction disorders, diseases affecting the eye and/or the lens and/or conditions affecting the inner ear, inflammatory disorders, liver diseases, pain, cancers, fibrotic disorders, psychotic disorders, infectious diseases, allergic disorders, traumatisms, septic, hemorrhagic and anaphylactic shock, diseases or disorders of the gastrointestinal system, angiogenesis and angiogenesis-dependent and other diseases and/or disorders associated with Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase), said method comprising administering an amido thiadiazole derivative according to Formula (I) to a patient in need thereof wherein X is selected from CR 1  and N; Y is selected from CH or N; A 1  is selected from \u2014OCHR 5 \u2014, \u2014NR 4 \u2014CHR 5 \u2014, \u2014CH 2 NR 4 \u2014 and \u2014CH 2 \u2014O\u2014; R 1  is selected from H, halogen and optionally substituted C 1 -C 6  alkyl; R 2  is selected from H, halogen, optionally substituted alkoxy, optionally substituted alkoxy C 1 -C 6  alkyl, optionally substituted C 1 -C 6  alkyl, optionally substituted amino, optionally substituted C 1 -C 6  alkyl amino, optionally substituted heterocycloalkyl, optionally substituted C 1 -C 6  alkyl heterocycloalkyl, optionally substituted amino C 1 -C 6  alkyl, optionally substituted alkoxy C 1 -C 6  alkyl, \u2014O\u2014R 8  and \u2014NR 9 R 10 ; R 3  is a group of formula \u2014(CHR 6 ) n A 2  or R 3  forms with the moiety CHR 5  from A 1  an optionally substituted ring selected from optionally substituted aryl and optionally substituted heteroaryl, or R 3  forms with the moiety NR 4  from A 1  an optionally substituted ring selected from optionally substituted aryl, optionally substituted heteroaryl; n is an integer from 0 to 4; R 4  is selected from H and optionally substituted alkyl; A 2  is an optionally substituted ring selected from optionally substituted aryl and optionally substituted heteroaryl; R 5  is selected from H, optionally substituted C 1 -C 6  alkyl, optionally substituted amino C 1 -C 6  alkyl, optionally substituted alkoxy C 1 -C 6  alkyl, optionally substituted heterocycloalkyl C 1 -C 6  alkyl, optionally substituted aminocarbonyl, optionally substituted C 2 -C 8  cycloalkyl and optionally substituted amino C 1 -C 6  alkyl; R 6  is selected from H, optionally substituted C 1 -C 6  alkyl, optionally substituted amino, optionally substituted C 1 -C 6  alkyl amino and hydroxy and wherein R 6  groups are independently selected for each repeating unit (CHR 6 ); R 7  is selected from H, halogen and optionally substituted C 1 -C 6  alkyl; R 8  is selected from H, optionally substituted C 1 -C 6  alkyl, optionally substituted amino C 1 -C 6  alkyl, optionally substituted heterocycloalkyl, optionally substituted C 2 -C 8  cycloalkyl, optionally substituted heterocycloalkyl C 1 -C 6  alkyl, optionally substituted C 2 -C 8  cycloalkyl C 1 -C 6  alkyl, optionally substituted alkoxy, optionally substituted amino C 1 -C 6  alkyl; optionally substituted aryl C 1 -C 6  alkyl and optionally substituted heteroaryl C 1 -C 6  alkyl; R 9  and R 10  are independently selected from H, optionally substituted C 1 -C 6  alkyl, optionally substituted amino C 1 -C 6  alkyl, optionally substituted heterocycloalkyl, optionally substituted C 2 -C 8  cycloalkyl, optionally substituted heterocycloalkyl C 1 -C 6  alkyl, optionally substituted C 2 -C 8  cycloalkyl C 1 -C 6  alkyl, optionally substituted alkoxy, optionally substituted alkoxy C 1 -C 6  alkyl, optionally substituted aryl C 1 -C 6  alkyl and optionally substituted heteroaryl C 1 -C 6  alkyl, optionally substituted amino C 1 -C 6  alkyl; as well as tautomers, geometrical isomers, optically active forms, pharmaceutically acceptable salts and a pharmaceutical formulation thereof.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 97.0
- Lexical Diversity: 1.16216
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15536800', '13120436', '13755387', '14750019', '13120440']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7259010795805781
- 35 USC 102 Novelty (BERT): 0.6151422829344497
- Combined Prediction Score: 0.7148251999159654
- Mean Citation Score: 405.248922
- Max Citation Score: 603.7789
- Similarity Product: 467.03274716420174

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test