PATENT CLAIM ANALYSIS

Application Number: 15881695
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-09
Patent Classification: ["514", "267000"]

Abstract:
Novel antiviral compounds of Formulae (I)-(III) are provided: The inventive compounds, pharmaceutical compositions thereof, and kits including the inventive compounds are useful for the prevention and treatment of infectious diseases caused by viruses, for example, by Flaviviridae virus (e.g., Dengue virus (DENV)), Kunjin virus, Japanese encephalitis virus, vesicular stomatitis virus (VSV), herpes simplex virus 1 (HSV-1), human cytomegalovirus (HCMV), poliovirus, Junin virus, Ebola virus, Marburg virus (MARV), Lassa fever virus (LASV), Venezuelan equine encephalitis virus (VEEV), or Rift Valley Fever virus (RVFV).

Claim (Index 3):
A compound of Formula (III): or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, co-crystal, tautomer, stereoisomer, isotopically labeled derivative, or prodrug thereof; wherein:\n Ring A is aryl, arylalkenyl, or heteroaryl; \n each instance of R A  is independently selected from the group consisting of hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, \u2014OR A1 , \u2014N(R A1 ) 2 , \u2014SR A1 , \u2014CN, \u2014C(\u2550NR A1 )R A1 , \u2014C(\u2550NR A1 )OR A1 , \u2014C(\u2550NR A1 )SR A1 , \u2014C(\u2550NR A1 )N(R A1 ) 2 , \u2014C(\u2550O)NR A1 \u2014, \u2014NR A1 C(\u2550O)\u2014, \u2014C(\u2550O)R A1 , \u2014C(\u2550S)R A1 , \u2014C(\u2550S)OR A1 , \u2014C(\u2550S)SR A1 , \u2014C(\u2550S)N(R A1 ) 2 , \u2014NO 2 , \u2014N 3 , \u2014N(R A1 ) 3 +F\u2014, \u2014N(R A1 ) 3 + Cl \u2212 , \u2014N(R A1 ) 3 + Br \u2212 , \u2014N(R A1 ) 3 + I \u2212 , \u2014N(OR A1 )R A1 , \u2014NR A1 C(\u2550O)R A1 , \u2014NR A1 C(\u2550O)OR A1 , \u2014NR A1 C(\u2550O)SR A1 , \u2014NR A1 C(\u2550O)N(R A1 ) 2 , \u2014NR A1 C(\u2550S)R A1 , \u2014NR A1 C(\u2550S)OR A1 , \u2014NR A1 C(\u2550S)SR A1 , \u2014NR A1 C(\u2550S)N(R A1 ) 2 , \u2014NR A1 C(\u2550NR A1 )R A1 , \u2014NR A1 C(\u2550NR A1 )OR A1 , \u2014NR A1 C(\u2550NR A1 )SR A1 , \u2014NR A1 C(\u2550NR A1 )N(R A1 ) 2 , \u2014NR A1 S(\u2550O) 2 R A1 , \u2014NR A1 S(\u2550O) 2 OR A1 , \u2014NR A1 S(\u2550O) 2 SR A1 , \u2014NR A1 S(\u2550O) 2 N(R A1 ) 2 , \u2014NR A1 S(\u2550O)R A1 , \u2014NR A1 S(\u2550O)OR A1 , \u2014NR A1 S(\u2550O)SR A1 , \u2014NR A1 S(\u2550O)N(R A1 ) 2 , \u2014NR A1 P(\u2550O), \u2014NR A1 P(\u2550O) 2 , \u2014NR A1 P(\u2550O)(R A1 ) 2 , \u2014NR A1 P(\u2550O)R A1 (OR A1 ), \u2014NR A1 P(\u2550O)(OR A1 ) 2 , \u2014OC(\u2550O)R A1 , \u2014OC(\u2550O)OR A1 , \u2014OC(\u2550O)SR A1 , \u2014OC(\u2550O)N(R A1 ) 2 , \u2014OC(\u2550NR A1 )R A1 , \u2014OC(\u2550NR A1 )OR A1 , \u2014OC(\u2550NR A1 )N(R A1 ) 2 , \u2014OC(\u2550S)R A1 , \u2014OC(\u2550S)OR A1 , \u2014OC(\u2550S)SR A1 , \u2014OC(\u2550S)N(R A1 ) 2 , \u2014ON(R A1 ) 2 , \u2014OS(\u2550O)R A1 , \u2014OS(\u2550O)OR A1 , \u2014OS(\u2550O)SR A1 , \u2014OS(\u2550O)N(R A1 ) 2 , \u2014OS(\u2550O) 2 R A1 , \u2014OS(\u2550O) 2 OR A1 , \u2014OS(\u2550O) 2 SR A1 , \u2014OS(\u2550O) 2 N(R A1 ) 2 , \u2014OP(\u2550O) 2 , \u2014OP(\u2550O)(R A1 ) 2 , \u2014OP(\u2550O)R A1 (OR A1 ), \u2014OP(\u2550O)(OR A1 ) 2 , \u2014OP(\u2550O), \u2014OP(R A1 ) 2 , \u2014OPR A1 (OR A1 ), \u2014OP(OR A1 ) 2 , \u2014OSi(R A1 ) 3 , \u2014OSi(R A1 ) 2 OR A1 , \u2014OSi(R A1 )(OR A1 ) 2 , \u2014OSi(OR A1 ) 3 , \u2014SSR A1 , \u2014S(\u2550O)R A1 , \u2014S(\u2550O)OR A1 , \u2014S(\u2550O)N(R A1 ) 2 , \u2014S(\u2550O) 2 R A1 , \u2014S(\u2550O) 2 OR A , \u2014S(\u2550O) 2 N(R A1 ) 2 , \u2014SC(\u2550O)R A1 , \u2014SC(\u2550O)OR A1 , \u2014SC(\u2550O)SR A1 , \u2014SC(\u2550O)N(R A1 ) 2 , \u2014SC(\u2550S)R A1 , \u2014SC(\u2550S)OR A1 , \u2014SC(\u2550S)SR A1 , \u2014SC(\u2550S)N(R A1 ) 2 , \u2014P(R A1 ) 2 , \u2014PR A1 (OR A1 ), \u2014P(OR A1 ) 2 , \u2014P(\u2550O), \u2014P(\u2550O)(R A1 ) 2 , \u2014P(\u2550O)(OR A1 ) 2 , \u2014P(\u2550O)R A1 (OR A1 ), \u2014P(\u2550O) 2 , \u2014B(R A1 ) 2 , \u2014B(OR A1 ) 2 , \u2014BR A1 (OR A1 ), \u2014Si(R A1 ) 3 , \u2014Si(R A1 ) 2 OR A1 , \u2014SiR A1 (OR A1 ) 2 , and \u2014Si(OR A1 ) 3 , wherein each occurrence of R A1  is independently selected from the group consisting of hydrogen, optionally substituted acyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, or two R A1  groups are joined to form an optionally substituted heterocyclic ring; \n k is 0, 1, 2, 3, 4, or 5; \n Ring C is a carbocyclic, heterocyclic, aryl, or heteroaryl ring; \n each instance of R C  is independently selected from the group consisting of hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, \u2014OR C1 , \u2014N(R C1 ) 2 , \u2014SR C1 , \u2014CN, \u2014C(\u2550NR C1 )R C1 , \u2014C(\u2550NR C1 )OR q , \u2014C(\u2550NR C1 )SR C1 , \u2014C(\u2550NR C1 )N(R C1 ) 2 , \u2014C(\u2550O)R C1 , \u2014C(\u2550S)R C1 , \u2014C(\u2550S)OR C1 , \u2014C(\u2550S)SR C1 , \u2014C(\u2550S)N(R C1 ) 2 , \u2014NO 2 , \u2014N 3 , \u2014N(R C1 ) 3 + F \u2212 , \u2014N(R C1 ) 3 + Cl \u2212 , \u2014N(R C1 ) 3 + Br \u2212 , \u2014N(R C1 ) 3 + I \u2212 , \u2014N(OR C1 )R C1 , \u2014NR C1 C(\u2550O)R C1 , \u2014NR C1 C(\u2550O)OR C1 , \u2014NR C1 C(\u2550O)SR C1 , \u2014NR C1 C(\u2550O)N(R C1 ) 2 , \u2014NR C1 C(\u2550S)R C1 , \u2014NR C1 C(\u2550S)OR C1 , \u2014NR C1 C(\u2550S)SR C1 , \u2014NR C1 C(\u2550S)N(R C1 ) 2 , \u2014NR C1 C(\u2550NR)R C1 , \u2014NR C1 C(\u2550NR C1 )OR C1 , \u2014NR C1 C(\u2550NR C1 )SR C1 , \u2014NR C1 C(\u2550NR C1 )N(R C1 ) 2 , \u2014NR C1 S(\u2550O) 2 R C1 , \u2014NR C1 S(\u2550O) 2 OR C1 , \u2014NR C1 S(\u2550O) 2 SR C1 , \u2014NR C1 S(\u2550O) 2 N(R C1 ) 2 , \u2014NR C1 S(\u2550O)R C1 , \u2014NR C1 S(\u2550O)OR C1 , \u2014NR C1 S(\u2550O)SR C1 , \u2014NR C1 S(\u2550O)N(R C1 ) 2 , \u2014NR C1 P(\u2550O), \u2014NR C1 P(\u2550O) 2 , \u2014NR C1 P(\u2550O)(R C1 ) 2 , \u2014NR C1 P(\u2550O)R C1 (OR C1 ), \u2014NR C1 P(\u2550O)(OR C1 ) 2 , \u2014OC(\u2550O)R C1 , \u2014OC(\u2550O)OR C1 , \u2014OC(\u2550O)SR C1 , \u2014OC(\u2550O)N(R C1 ) 2 , \u2014OC(\u2550NR C1 )R C1 , \u2014OC(\u2550NR C1 )OR C1 , \u2014OC(\u2550NR C1 )N(R C1 ) 2 , \u2014OC(\u2550S)R C1 , \u2014OC(\u2550S)OR C1 , \u2014OC(\u2550S)SR C1 , \u2014OC(\u2550S)N(R C1 ) 2 , \u2014ON(R C1 ) 2 , \u2014OS(\u2550O)R C1 , \u2014OS(\u2550O)OR C1 , \u2014OS(\u2550O)SR C1 , \u2014OS(\u2550O)N(R C1 ) 2 , \u2014OS(\u2550O) 2 R C1 , \u2014OS(\u2550O) 2 OR C1 , \u2014OS(\u2550O) 2 SR C1 , \u2014OS(\u2550O) 2 N(R C1 ) 2 , \u2014OP(\u2550O) 2 , \u2014OP(\u2550O)(R C1 ) 2 , \u2014OP(\u2550O)R C1 (OR C1 ), \u2014OP(\u2550O)(OR C1 ) 2 , \u2014OP(\u2550O), \u2014OP(R C1 ) 2 , \u2014OPR C1 (OR C1 ), \u2014OP(OR C1 ) 2 , \u2014OSi(R C1 ) 3 , \u2014OSi(R C1 ) 2 OR C1 , \u2014OSi(R C1 )(OR C1 ) 2 , \u2014OSi(OR C1 ) 3 , \u2014SSR C1 , \u2014S(\u2550O)R C1 , \u2014S(\u2550O)OR C1 , \u2014S(\u2550O)N(R C1 ) 2 , \u2014S(\u2550O) 2 R C1 , \u2014S(\u2550O) 2 OR C1 , \u2014S(\u2550O) 2 N(R C1 ) 2 , \u2014SC(\u2550O)R C1 , \u2014SC(\u2550O)OR C1 , \u2014SC(\u2550O)SR C1 , \u2014SC(\u2550O)N(R C1 ) 2 , \u2014SC(\u2550S)R C1 , \u2014SC(\u2550S)OR C1 , \u2014SC(\u2550S)SR C1 , \u2014SC(\u2550S)N(R C1 ) 2 , \u2014P(R C1 ) 2 , \u2014PR C1 (OR C1 ), \u2014P(OR C1 ) 2 , \u2014P(\u2550O), \u2014P(\u2550O)(R C1 ) 2 , \u2014P(\u2550O)(OR C1 ) 2 , \u2014P(\u2550O)R C1 (OR C1 ), \u2014P(\u2550O) 2 , \u2014B(R C1 ) 2 , \u2014B(OR C1 ) 2 , \u2014BR C1 (OR C1 ), \u2014Si(R C1 ) 3 , \u2014Si(R C1 ) 2 OR C1 , \u2014SiR C1 (OR C1 ) 2 , and \u2014Si(OR C1 ) 3 , wherein each occurrence of R C1  is independently selected from the group consisting of hydrogen, optionally substituted acyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, or two R C1  groups are joined to form an optionally substituted heterocyclic ring or optionally substituted heteroaryl ring; \n R q  is independently hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group; \n n is 0, 1, 2, 3, or 4; \n L is a bond or an optionally substituted, branched or unbranched C 1-6  hydrocarbon chain;\n R D  is any one of Formulae (i-1)-(i-43): \n \n wherein: each instance of R D1  is independently hydrogen, halogen, acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014CN, \u2014NO 2 , \u2014OR D1a , \u2014N(R D1a ) 2 , \u2014SR D1a , \u2014CH 2 OR D1a , \u2014CH 2 N(R D1a ) 2 , \u2014CH 2 SR D1a , \u2014C(\u2550O)R D1a , \u2014C(\u2550O)OR D1a , \u2014C(\u2550O)SR D1a , \u2014C(\u2550O)N(R D1a ) 2 , \u2014C(\u2550S)R D1a , \u2014C(\u2550S)OR D1a , \u2014C(\u2550S)SR D1a , \u2014C(\u2550S)N(R D1a ) 2 , \u2014C(\u2550NR D1a )R D1a , \u2014C(\u2550NR D1a )OR D1a  C(\u2550NR D1a )SR D1a , or \u2014C(\u2550NR D1a )N(R D1a ) 2 , wherein each occurrence of R D1a  is independently hydrogen, acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or two R D1a  groups are joined to form an substituted or unsubstituted heterocyclic ring; each instance of R D2  is independently hydrogen, halogen, acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014CN, \u2014NO 2 , \u2014OR D2a , \u2014N(R D2a ) 2 , \u2014SR D2a , \u2014CH 2 OR D2a CH 2 N(R D2a ) 2 , \u2014CH 2 SR D2a , \u2014C(\u2550O)R D2a , \u2014C(\u2550O)OR D2a , \u2014C(\u2550O)SR D2a , \u2014C(\u2550O)N(R D2a ) 2 , \u2014C(\u2550S)R D2a , \u2014C(\u2550S)OR D2a , \u2014C(\u2550S)SR D2a , \u2014C(\u2550S)N(R D2a ) 2 , \u2014C(\u2550NR D2a )R D2a , \u2014C(\u2550NR D2a )OR D2a , \u2014C(\u2550NR D2a )SR D2a , and \u2014C(\u2550NR D2a )N(R D2a ) 2 , wherein each occurrence of R D2a  is independently hydrogen, acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, or two R D2a  groups are joined to form an substituted or unsubstituted heterocyclic ring; each instance of R D3  is independently hydrogen, halogen, acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, \u2014OR D3a , \u2014N(R D3a ) 2 , \u2014SR D3a , \u2014CH 2 OR D3a , \u2014CH 2 N(R D3a ) 2 , \u2014CH 2 SR D3a , \u2014C(\u2550O)R D3a , \u2014C(\u2550O)OR D3a , \u2014C(\u2550O)SR D3a , \u2014C(\u2550O)N(R D3a ) 2 , \u2014C(\u2550S)R D3a , \u2014C(\u2550S)OR D3a , \u2014C(\u2550S)SR D3a , \u2014C(\u2550S)N(R D3a ) 2 , \u2014C(\u2550NR D3a )R D3a , \u2014C(\u2550NR D3a )OR D3a , \u2014C(\u2550NR D3a )SR D3a , or \u2014C(\u2550NR D3a )N(R D3a ) 2  wherein each occurrence of R D3a  is independently hydrogen, acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or two R D3a  groups are joined to form an substituted or unsubstituted heterocyclic ring; optionally R D1  and R D3 , or R D2  and R D3 , or R D1  and R D2  are joined to form an substituted or unsubstituted carbocyclic or substituted or unsubstituted heterocyclic ring; R D4  is a leaving group selected from the group consisting of \u2014Br, \u2014Cl, \u2014I, and \u2014OS(\u2550O) w R D4a , wherein w is 1 or 2, and R D4a  is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;\n each instance of X 1  is independently a bond, \u2014C(\u2550O)\u2014, \u2014SO 2 \u2014, \u2014NR D5 \u2014, optionally substituted alkylene, or optionally substituted heteroarylene, wherein R D5  is hydrogen, C 1-6  alkyl, or a nitrogen protecting group; \n each instance of Y is independently O, S, or NR D6 , wherein R D6  is hydrogen, C 1-6  alkyl, or a nitrogen protecting group; and \n each instance of z and z 1  is independently 0, 1, 2, 3, 4, 5, or 6, as valency permits.

Metadata:
- Claim Count in Document: 25.0
- Percentile: 86.0
- Lexical Diversity: 1.83824
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14391638', '14436387', '15104132', '15847430', '15114895']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8463007102210994
- 35 USC 102 Novelty (BERT): 0.6842391703675951
- Combined Prediction Score: 0.830094556235749
- Mean Citation Score: 556.130642
- Max Citation Score: 762.80365
- Similarity Product: 676.3005473427236

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test