PATENT CLAIM ANALYSIS

Application Number: 16265864
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-05
Patent Classification: ["514", "04400R"]

Abstract:
Disclosed are materials and methods for treating diseases of the mammalian eye, and in particular, Usher syndrome 1B (USH1B). The invention provides AAV-based, dual-vector systems that facilitate the expression of full-length proteins whose coding sequences exceed that of the polynucleotide packaging capacity of an individual AAV vector. In one embodiment, vector systems are provided that include i) a first AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a suitable promoter followed by a partial coding sequence that encodes an N-terminal portion of a full-length polypeptide; and ii) a second AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a partial coding sequence that encodes a C-terminal portion of a full-length polypeptide, optionally followed by a polyadenylation (pA) signal sequence. In another embodiment, the vector system includes i) a first AAV vector polynucleotide comprising an inverted terminal repeat at each end, a suitable promoter followed by a partial coding sequence that encodes an N-terminal portion of a full-length polypeptide followed by a splice donor site and intron and ii) a second AAV vector polynucleotide comprising an inverted terminal repeat at each end, followed by an intron and a splice-acceptor site for the intron, followed by a partial coding sequence that encodes a C-terminal portion of a full-length polypeptide, optionally followed by a polyadenylation (pA) signal sequence. The coding sequence or the intron sequence in the first and second AAV vectors preferably includes a sequence region that overlaps.

Claim (Index 33):
An isolated host cell comprising the polynucleotide vector system of  claim 26 .

Metadata:
- Claim Count in Document: 8.0
- Percentile: 99.0
- Lexical Diversity: 3.07778
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14279142', '14785229', '15127757', '14354471', '10415834']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7831188629108911
- 35 USC 102 Novelty (BERT): 0.6790105137576762
- Combined Prediction Score: 0.7727080279955696
- Mean Citation Score: 438.366416
- Max Citation Score: 742.43445
- Similarity Product: 658.0331703809737

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test