PATENT CLAIM ANALYSIS

Application Number: 16129020
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["514", "510000"]

Abstract:
A method treats patient with treatment resistant depression, adjunct to standard antidepressant treatment or as monotherapy. These patients will be identified by non-response to at least one pharmacological antidepressant treatment with a sufficient dose and over a sufficient period of time. Further, one embodiment of the method includes a procedure to identify patients who would benefit from a combination of standard antidepressants with the described compounds from the start of the treatment in order to maximize the likelihood of response. Another embodiment of the method combines the described compounds with forms of Magnesium salts in order to overcome longer term tolerability issues with the compounds. An important downstream mechanism of the described interventions is the property to reduce the production and or increase the absorption of cerebrospinal fluid to treat a variety of symptoms, including cognitive dysfunction, memory loss, apathy, sleep disturbances, pain disorders, and somatoform pain and headache.

Claim (Index 16):
The method according to  claim 8 , further comprising a procedure for identifying patients suffering from depression susceptible to therapeutic benefit from treatment with the preparation, based on A) one or more clinical signs, comprising depression, anxiety, somatization, cognitive dysfunction, memory problems, gait disturbance, and bladder dysfunction, with B) one or more biomarker signs, comprising low systolic blood pressure, orthostatic hypotension, low plasma sodium concentration, high plasma potassium concentration, high plasma magnesium concentration, high plasma or saliva aldosterone concentration, high plasma or saliva aldosterone/cortisol ratio, high plasma or saliva vasopressin concentrations, high volume of cerebral ventricles, high volume of the choroid plexus, and increased intraocular pressure.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 97.0
- Lexical Diversity: 1.7234
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14765094', '15095248', '14904233', '13371227', '14178312']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7147539298305084
- 35 USC 102 Novelty (BERT): 0.4940171156461768
- Combined Prediction Score: 0.6926802484120753
- Mean Citation Score: 137.314865
- Max Citation Score: 184.37675
- Similarity Product: 118.59162748689948

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test