PATENT CLAIM ANALYSIS

Application Number: 16017489
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["530", "387100"]

Abstract:
Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

Claim (Index 53):
The antibody of any one of  claims 1 - 52 , wherein the antibody comprises:\n (a1) heavy and light chain sequences comprising SEQ ID NOs: 301 (or 302) and 29, respectively; (a2) heavy and light chain sequences comprising SEQ ID NOs: 1 (or 8) and 29, respectively; (a3) heavy and light chain sequences comprising SEQ ID NOs: 15 (or 22) and 29, respectively; (a4) heavy and light chain sequences comprising SEQ ID NOs: 303 (or 304) and 29, respectively; (a5) heavy and light chain sequences comprising SEQ ID NOs: 72 (or 82) and 29, respectively; (a6) heavy and light chain sequences comprising SEQ ID NOs: 92 (or 102) and 29, respectively; (a7) heavy and light chain sequences comprising SEQ ID NOs: 305 (or 306) and 29, respectively; (a8) heavy and light chain sequences comprising SEQ ID NOs: 73 (or 83) and 29, respectively; (a9) heavy and light chain sequences comprising SEQ ID NOs: 93 (or 103) and 29, respectively; (a10) heavy and light chain sequences comprising SEQ ID NOs: 307 (or 308) and 29, respectively; (a11) heavy and light chain sequences comprising SEQ ID NOs: 74 (or 84) and 29, respectively; (a12) heavy and light chain sequences comprising SEQ ID NOs: 94 (or 104) and 29, respectively; (a13) heavy and light chain sequences comprising SEQ ID NOs: 309 (or 310) and 29, respectively; (a14) heavy and light chain sequences comprising SEQ ID NOs: 75 (or 85) and 29, respectively; (a15) heavy and light chain sequences comprising SEQ ID NOs: 95 (or 105) and 29, respectively; (a16) heavy and light chain sequences comprising SEQ ID NOs: 311 (or 312) and 29, respectively; (a17) heavy and light chain sequences comprising SEQ ID NOs: 76 (or 86) and 29, respectively; (a18) heavy and light chain sequences comprising SEQ ID NOs: 96 (or 106) and 29, respectively; (a19) heavy and light chain sequences comprising SEQ ID NOs: 313 (or 314) and 29, respectively; (a20) heavy and light chain sequences comprising SEQ ID NOs: 77 (or 87) and 29, respectively; (a21) heavy and light chain sequences comprising SEQ ID NOs: 97 (or 107) and 29, respectively; (a22) heavy and light chain sequences comprising SEQ ID NOs: 315 (or 316) and 29, respectively; (a23) heavy and light chain sequences comprising SEQ ID NOs: 78 (or 88) and 29, respectively; (a24) heavy and light chain sequences comprising SEQ ID NOs: 98 (or 108) and 29, respectively; (a25) heavy and light chain sequences comprising SEQ ID NOs: 317 (or 318) and 29, respectively; (a26) heavy and light chain sequences comprising SEQ ID NOs: 79 (or 89) and 29, respectively; (a27) heavy and light chain sequences comprising SEQ ID NOs: 99 (or 109) and 29, respectively; (a28) heavy and light chain sequences comprising SEQ ID NOs: 319 (or 320) and 29, respectively; (a29) heavy and light chain sequences comprising SEQ ID NOs: 349 (or 350) and 29, respectively; (a30) heavy and light chain sequences comprising SEQ ID NOs: 351 (or 352) and 29, respectively; (a31) heavy and light chain sequences comprising SEQ ID NOs: 353 (or 354) and 29, respectively; (b1) heavy and light chain sequences comprising SEQ ID NOs: 321 (or 322) and 30, respectively; (b2) heavy and light chain sequences comprising SEQ ID NOs: 2 (or 9) and 30, respectively; (b3) heavy and light chain sequences comprising SEQ ID NOs: 16 (or 23) and 30, respectively; (b4) heavy and light chain sequences comprising SEQ ID NOs: 323 (or 324) and 30, respectively; (b5) heavy and light chain sequences comprising SEQ ID NOs: 80 (or 90) and 30, respectively; (b6) heavy and light chain sequences comprising SEQ ID NOs: 100 (or 110) and 30, respectively; (b7) heavy and light chain sequences comprising SEQ ID NOs: 325 (or 326) and 30, respectively; (c1) heavy and light chain sequences comprising SEQ ID NOs: 327 (or 328) and 30, respectively; (c2) heavy and light chain sequences comprising SEQ ID NOs: 3 (or 10) and 30, respectively; (c3) heavy and light chain sequences comprising SEQ ID NOs: 17 (or 24) and 30, respectively; (c4) heavy and light chain sequences comprising SEQ ID NOs: 329 (or 330) and 30, respectively; (d1) heavy and light chain sequences comprising SEQ ID NOs: 331 (or 332) and 29, respectively; (d2) heavy and light chain sequences comprising SEQ ID NOs: 4 (or 11) and 29, respectively; (d3) heavy and light chain sequences comprising SEQ ID NOs: 18 (or 25) and 29, respectively; (d4) heavy and light chain sequences comprising SEQ ID NOs: 333 (or 334) and 29, respectively; (e1.1) heavy and light chain sequences comprising SEQ ID NOs: 335 (or 336) and 32, respectively; (e1.2) heavy and light chain sequences comprising SEQ ID NOs: 335 (or 336) and 33, respectively; (e1.3) heavy and light chain sequences comprising SEQ ID NOs: 335 (or 336) and 31, respectively; (e2) heavy and light chain sequences comprising SEQ ID NOs: 5 (or 12) and 33, respectively; (e3) heavy and light chain sequences comprising SEQ ID NOs: 19 (or 26) and 33, respectively; (e4) heavy and light chain sequences comprising SEQ ID NOs: 337 (or 338) and 33, respectively; (e5) heavy and light chain sequences comprising SEQ ID NOs: 81 (or 91) and 33, respectively; (e6) heavy and light chain sequences comprising SEQ ID NOs: 101 (or 111) and 33, respectively; (e7) heavy and light chain sequences comprising SEQ ID NOs: 339 (or 340) and 33, respectively; (f1) heavy and light chain sequences comprising SEQ ID NOs: 341 (or 342) and 29, respectively; (f2) heavy and light chain sequences comprising SEQ ID NOs: 6 (or 13) and 29, respectively; (f3) heavy and light chain sequences comprising SEQ ID NOs: 20 (or 27) and 29, respectively; (f4) heavy and light chain sequences comprising SEQ ID NOs: 343 (or 344) and 29, respectively; (g1) heavy and light chain sequences comprising SEQ ID NOs: 345 (or 346) and 29, respectively; (g2) heavy and light chain sequences comprising SEQ ID NOs: 7 (or 43) and 30, respectively; (g3) heavy and light chain sequences comprising SEQ ID NOs: 21 (or 28) and 30, respectively; or (g4) heavy and light chain sequences comprising SEQ ID NOs: 347 (or 348) and 30, respectively; wherein the antibody specifically binds to human TIM3.

Metadata:
- Claim Count in Document: 45.0
- Percentile: 94.0
- Lexical Diversity: 2.08511
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15649380', '15520638', '13478786', '14732082', '15474731']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7408836763187108
- 35 USC 102 Novelty (BERT): 0.6845680078353616
- Combined Prediction Score: 0.7352521094703759
- Mean Citation Score: 596.4244480000001
- Max Citation Score: 837.39594
- Similarity Product: 662.35598807397

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test