PATENT CLAIM ANALYSIS

Application Number: 15756051
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "006120"]

Abstract:
Described herein, among other things, is a method of sequencing, comprising: concatenating a plurality of fragments of genomic DNA to produce concatenated DNA; sequencing the concatenated DNA to produce a plurality of sequence reads, wherein at least some of the sequence reads comprise: at least the sequence of the 3′ and/or 5′ ends of a fragment that corresponds to the locus of interest and sequence of one or both of the fragments that flank the fragment in the concatenated DNA; and grouping the sequence reads that corresponds to the locus of interest using, for each of the grouped sequence reads: the 3′ and/or 5′ end sequences; and/or the flanking sequence.

Claim (Index 1):
A method of sequencing, comprising:\n (a) concatenating a plurality of fragments of genomic DNA to produce concatenated DNA; (b) sequencing fragments of the concatenated DNA, or amplification products thereof, to produce a plurality of sequence reads, wherein at least some of the sequence reads comprise:\n (i) at least the sequence of the 3\u2032 and/or 5\u2032 ends of a fragment that corresponds to the locus of interest; and \n (ii) sequence of one or both of the fragments that flank the fragment of (b)(i) in the concatenated DNA of (a); and \n (c) grouping the sequence reads that corresponds to the locus of interest using, for each of the grouped sequence reads:\n (i) the 3\u2032 and/or 5\u2032 end sequences of (b)(i); and/or \n (ii) the flanking sequence of (b)(ii), \n (d) determining which groups of sequence reads of (c) contain a potential sequence variation for the locus of interest; and (e) calculating a probability that the potential sequence variation is a genuine mutation or an artifact using:\n (i) the number of reads in the group that contain the potential sequence variation, \n (ii) the number of groups that contain the potential sequence variation, and \n (iii) the total number of groups corresponding to the locus of interest.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 88.0
- Lexical Diversity: 2.25926
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14782307', '14540917', '13608770', '13975215', '15382508']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5854684101924845
- 35 USC 102 Novelty (BERT): 0.4845973501354779
- Combined Prediction Score: 0.5753813041867839
- Mean Citation Score: 205.072138
- Max Citation Score: 211.8221
- Similarity Product: 154.24674864674807

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test