PATENT CLAIM ANALYSIS

Application Number: 15742947
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-03
Patent Classification: ["514", "415000"]

Abstract:
Indoline and tetrahydroquinoline sulfonyl compounds that can inhibit DapE and/or bacterial metallo-62 -lactamases (“MBLs”), such as NDM-1 are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the compounds disclosed herein.

Claim (Index 1):
A compound having a structure of Formula (I), or a pharmaceutically acceptable salt thereof: wherein m is 1 or 2; A is C\u2550O or SO 2 ; X is H, C 1-6 alkyl, halo, OH, C 1-6 alkoxy, aryl, or heteroaryl having 1, 2, 3, or 4 heteroatoms selected from N, O, and S; Z is n is 0 or 1; W is NR 3 R 4  or OR 7 ; Y is O, S, or NR 6 ; R 1  is C 1-6 alkyl, C 2-6 alkenyl, C 1-4 alkylene-OH, C 1-4 alkylene-CN, C 1-4 alkylene-halo, C 1-4 alkylene-NR 6 2 , C 0-4 alkylene-R 5 , C 1-4 alkylene-C(\u2550O)R 5 , C 1-4 alkylene-C(\u2550O)OR 5 , C 1-4 alkylene-NHC(O)R 5 , C 1-4 alkylene-NHC(O)OR 5 , C 1-4 alkylene-C(\u2550NOR 6 )R 5 , or C 1-4 alkylene-OSO 2 R 5 ; R 2  is C 1-6 alkyl, C 2-6 alkenyl, C 1-4 alkylene-CN, C 1-4 alkylene-halo, C 0-4 alkylene-R 5 , C 0-4 alkylene-OR 5 , or C 1-4 alkylene-SO 2 R 5 ; R 3  and R 4  are each independently H, C 1-4 alkyl, C 0-4 alkylene-C(O)C 1-4 alkyl, C 0-4 alkylene-CO 2 R 6 , C 0-4 alkylene-NR 6 2 , C 0-4 alkylene-C 3-6 cycloalkyl, C 0-4 alkylene-C 3-6 heterocycloalkyl having 1, 2, or 3 heteroatoms selected from N, O and S, or C 0-4 alkylene-C 6-10 aryl, or R 3  and R 4  are taken together with the nitrogen to which they are attached to form a 5-7 membered ring; R 5  is H, C 1-6 alkyl, C 2-6 alkenyl, C 0-4 alkylene-C 3-6 cycloalkyl, C 0-4 alkylene-C 3-6 heterocycloalkyl having 1, 2, or 3 heteroatoms selected from N, O and S, C 0-4 alkylene-C 6-10 aryl, C 2-4 alkenylene-C 6-10 aryl, C 0-4 alkylene-C 5-10 heteroaryl having 1, 2, 3, or 4 heteroatoms selected from N, O, and S, or NR 3 R 4 ; each R 6  independently is H or C 1-3 alkyl; and R 7  is H, C 1-6 alkyl, C 0-4 alkylene-C 6-10 aryl, or C 0-4 alkylene-C(O)\u2014C 1-4 alkylene-NR 6 2 .

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 1.15789
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15501489', '10851428', '15323081', '10888849', '14146643']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7606686313803921
- 35 USC 102 Novelty (BERT): 0.5047359721655131
- Combined Prediction Score: 0.7350753654589042
- Mean Citation Score: 231.8951
- Max Citation Score: 258.33267
- Similarity Product: 187.0143389791453

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test