PATENT CLAIM ANALYSIS

Application Number: 15914945
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["540", "460000"]

Abstract:
The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.

Claim (Index 1):
A compound of the structure: wherein\n A b1  and A b2  are members independently selected from: \n wherein each R 7 , and R 8  is independently selected from a bond to L 1  or L 2 , alkanediyl attached to L 1  or L 2 , H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, halogen, CN, \u2014CF 3 , \u2014C(O)R 17 , \u2014SO 2 NR 17 R 18 , \u2014NR 17 R 18 , \u2014OR 17 , \u2014S(O) 2 R 17 , \u2014COOR 17 , \u2014S(O) 2 OR 17 , \u2014OC(O)R 17 , \u2014C(O)NR 17 R 18 , \u2014NR 17 C(O)R 8 , \u2014NR 17 SO 2 R 18 , and \u2014NO 2 , wherein at least two of, R 7 , and R 8 , are optionally joined to form a ring system selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; 17 R 17  and R 18  are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl; and R 17  and R 18 , together with the atoms to which they are attached, are optionally joined to form a 5-, 6- or 7-membered ring; L 1a  is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted biaryl, substituted or unsubstituted heteroaryl, and a substituted or unsubstituted polycyclic ring system; L x6  is independently selected from H, a linker to a reactive functional group, and a linker to a targeting moiety; L 2a , L 2b  and L 2c  are independently selected from substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl; wherein A p1 , and A p2  are independently selected from: wherein\n A and G are independently selected from carbon, nitrogen and oxygen; \n J is selected from carbon and nitrogen; \n each R 1\u2032  and R 2\u2032  is independently selected from H, an enzymatically labile group, a hydrolytically labile group, a metabolically labile group, a photolytically labile group and a single negative charge; \n each R 6\u2032 , R 7\u2032 , R 8\u2032 , R 9\u2032 , and R 10\u2032  moiety is independently selected from a bond linking the moiety to the remainder of the compound, alkanediyl linking the moiety to the remainder of the molecule, H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, halogen, CN, \u2014CF 3 , \u2014C(O)R 17\u2032 , \u2014SO 2 NR 17\u2032 R 18\u2032 , \u2014N R 17\u2032 R 18\u2032 , \u2014OR 17\u2032 , \u2014S(O) 2 R 17\u2032 , \u2014COOR 17\u2032 , \u2014S(O) 2 OR 17\u2032 , \u2014OC(O)R 17\u2032 , \u2014C(O)N R 17\u2032 R 18\u2032 , \u2014NR 17\u2032 C(O)R 18\u2032 , \u2014NR 17\u2032 SO 2 R 18\u2032 , and \u2014NO 2 , \n wherein\n at least two of R 6\u2032 , R 7\u2032 , R 8\u2032 , R 9\u2032 , and R 10\u2032  are optionally joined to form a ring system selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; \n R 17\u2032  and R 18\u2032  are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl; and \n R 17\u2032  and R 18\u2032 , together with the atoms to which they are attached, are optionally joined to form a 5-, 6- or 7-membered ring; \n when A is oxygen, R 9\u2032  is not present; and \n when G is oxygen, R 7\u2032  is not present; and \n A p1  and A p2  are attached to C1 and C2, respectively, through a member selected from R 6 , R 7 , R 8 , R 9  and R 10 .

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.14286
- Patent Class: 540.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11839509', '13460120', '12521910', '15053713', '15538610']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7099988527716025
- 35 USC 102 Novelty (BERT): 0.525267237985049
- Combined Prediction Score: 0.691525691292947
- Mean Citation Score: 296.704412
- Max Citation Score: 324.36057
- Similarity Product: 259.8509610520667

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test