PATENT CLAIM ANALYSIS

Application Number: 16309080
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-04
Patent Classification: ["514", "210160"]

Abstract:
Fused aromatic bicyclic substituted 5-(2-amino-4-pyrimidinyl)-cyanoindoline derivatives (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-KB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

Claim (Index 2):
The compound according to  claim 1 , wherein R 3  represents a fused bicyclic ring system of formula (1a-1) or (1a-2): ring A1 represents phenyl or a 6-membered heteroaromatic ring containing 1 or 2 N-atoms; ring A2 represents 2-oxo-1,2-dihydropyridin-3-yl; ring B1 represents a 4- to 7-membered saturated heterocyclyl containing one or two heteroatoms each independently selected from O, S, S(\u2550O) p  and N; wherein (1a-1) and (1a-2) may optionally be substituted on the ring carbon atoms with in total one, two or three substituents each independently selected from the group consisting of halo; cyano; oxo; \u2014OH; C 1-6 alkyl; \u2014O\u2014C 1-4 alkyl; \u2014C(\u2550O)\u2014R 10 ; \u2014S(\u2550O) 2 \u2014C 1-4 alkyl; \u2014S(\u2550O)(\u2550N\u2014R 20a )\u2014C 1-4 alkyl; \u2014O\u2014C 1-4 alkyl substituted with one, two or three halo atoms; \u2014O\u2014C 1-4 alkyl-R 12 ; C 3-6 cycloalkyl; \u2014O\u2014C 3-6 cycloalkyl; Het 1a ; \u2014O-Het 1b ; R 18 ; \u2014P(\u2550O)\u2014(C 1-4 alkyl) 2 ; \u2014NH\u2014C(\u2550O)\u2014C 1-4 alkyl; \u2014NH\u2014C(\u2550O)-Het 1g ; \u2014NR 17a R 17b ; C 1-4 alkyl substituted with one, two or three halo atoms; C 1-4 alkyl substituted with one, two or three \u2014OH substituents; C 1-4 alkyl substituted with one R 13 ; C 1-4 alkyl substituted with one R 18 ; C 2-6 alkenyl; and C 2-6 alkenyl substituted with one R 13 ; wherein ring A2 may optionally be substituted, where possible, on the N-atom with a substituent selected from the group consisting of C 1-6 alkyl; C 3-6 cycloalkyl; Het 1a ; R 18 ; C 1-4 alkyl substituted with one, two or three halo atoms; C 1-4 alkyl substituted with one, two or three \u2014OH substituents; C 1-4 alkyl substituted with one R 13 ; C 1-4 alkyl substituted with one R 18 ; C 2-6 alkenyl; and C 2-6 alkenyl substituted with one R 13 ; provided that when Het 1a  or R 18  are directly attached to the N-atom of ring A2, said Het 1a  or R 18  are attached to the N-atom via a ring carbon atom; and wherein ring B1 may optionally be substituted, where possible, on one or two ring N-atoms with a substituent each independently selected from the group consisting of C 1-6 alkyl; C 3-6 cycloalkyl; Het 1a ; R 18 ; C 1-4 alkyl substituted with one, two or three halo atoms; C 1-4 alkyl substituted with one, two or three \u2014OH substituents; C 1-4 alkyl substituted with one R 13 ; C 1-4 alkyl substituted with one R 18 ; \u2014(C\u2550O)\u2014C 1-4 alkyl; \u2014C(\u2550O)NR 14g R 14h ; \u2014C(\u2550O)\u2014C 1-4 alkyl-NR 14i R 14j ; \u2014C(\u2550O)\u2014C(\u2550O)\u2014NR 14k R 14l ; C 2-6 alkenyl; and C 2-6 alkenyl substituted with one R 13 ; provided that when Het 1a  or R 18  are directly attached to the N-atom of ring B1, said Het 1a  or R 18  are attached to the N-atom via a ring carbon atom.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 98.0
- Lexical Diversity: 1.75439
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15024603', '15766887', '15520342', '15755475', '13321158']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7980101843750286
- 35 USC 102 Novelty (BERT): 0.5378065454970519
- Combined Prediction Score: 0.7719898204872309
- Mean Citation Score: 341.545594
- Max Citation Score: 364.57202
- Similarity Product: 276.3987925653195

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test