PATENT CLAIM ANALYSIS

Application Number: 16107502
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "001000"]

Abstract:
Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene amplification of a CHDIL gene or an RTEL1 gene in a tumor sample from the subject. Further provided are methods of treating a tumor with a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a subject by administering an effective dose of a PARP inhibitor.

Claim (Index 13):
The method of  claim 2 , wherein the PARP inhibitor is selected from the group consisting of isoindolinone derivatives, ABT472, ABT767, ABT888 (veliparib), AZD2281 (olaparib), AZD2461, BeiGene290, BMN673, BSI101, BS1201 (iniparib), BS1401, CEP8983, CEP9722, CO338 (rucaparib phosphate), CPH101 with CPH102, E7016, E7449, IMP04149, IMP4297, INO1001, IN01003, JP1283, JP1289, KU0687, MK4827 (niraparib), NT125, SOMCL9112, and 4-methoxy-carbazole derivatives.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 96.0
- Lexical Diversity: 2.24444
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14793878', '15524242', '15746806', '15494426', '13783785']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.802854842245636
- 35 USC 102 Novelty (BERT): 0.485447870361061
- Combined Prediction Score: 0.7711141450571785
- Mean Citation Score: 240.39025
- Max Citation Score: 245.8771
- Similarity Product: 209.64049646247628

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test