PATENT CLAIM ANALYSIS

Application Number: 15767676
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "275000"]

Abstract:
Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Claim (Index 26):
The compound according to  claim 25 , wherein Q 1  is selected from: wherein R 6a , R 6b , R 6c , R 6d , R 6e  are independently selected from hydrogen, halogen, hydroxyl, amino, (CH 2 ) n R 3d , (CH 2 ) n OR 3d , (CH 2 ) n SR 3d , (CH 2 ) n S(O)R 3d , (CH 2 ) n SO 2 R 3d , (CH 2 ) n N(R 3c )R 3d , (CH 2 ) n C(O)R 3d , (CH 2 ) n N(R 3c )C(O)R 3d , (CH 2 ) n OC(O)R 3d , (CH 2 ) n C(O)OR 3d , (CH 2 ) n C(O)N(R 3c )R 3d , (CH 2 ) n N(R 3c )C(O)N(R 3c )R 3d , (CH 2 ) n SO 2 N(R 3c )R 3d , (CH 2 ) n N(R 3c )SO 2 R 3d , (CH 2 ) n SO 2 N(R 3c )R 3d , (CH 2 ) n N(R 3c )SO 2 R 3d , (CH 2 ) n N(R 3c )P(O)(R 3d ) 2 , (CH 2 ) n P(O)(N(R 3c R 3d )) 2 , and poly(ethylene oxide); R 3d  is independently selected from hydrogen, substituted or unsubstituted C 1 -C 6  alkyl, and substituted or unsubstituted C 3 -C 10  cycloalkyl; or two of R 3b , R 6a , R 6b , R 6c , R 6d , R 6e , R 3c  and R 3d  together form a ring; wherein A, B and C are independently selected from a bond, O, \u2014C(R 6 ) 2 \u2014, \u2014C(R 6 ) 2 \u2014C(R 6 ) 2 \u2014, \u2014C(R 6 ) 2 \u2014N(R 6 )\u2014, \u2014C(R 6 ) 2 \u2014O\u2014, NR 6 , S, SO, and SO 2 ; wherein A is O, NR 6 , S, SO, SO 2 , \u2014C(R 6 )\u2550C(R 6 )\u2014, or \u2014C(R 6 )\u2550N\u2014; and B and C are either N or CR 6 , wherein B is O, NR 6 , S, SO, SO 2 , \u2014C(R 6 )\u2550C(R 6 )\u2014, or \u2014C(R 6 )\u2550N\u2014; and A and C are either N or CR 6 , wherein C is O, NR 6 , S, SO, SO 2 , \u2014C(R 6 )\u2550C(R 6 )\u2014, or \u2014C(R 6 )\u2550N\u2014; A and B are either N or CR 6 , one R 6  group represents a bond to L 1 , and the remaining R 6  groups are independently selected from hydrogen, halogen, hydroxyl, amino, nitro, cyano, isocyano, carboxyl, (CH 2 ) n OR 3d , (CH 2 ) n SR 3d , (CH 2 ) n S(O)R 3d , (CH 2 ) n SO 2 R 3d , (CH 2 ) n N(R 3c )R 3d , (CH 2 ) n C(O)R 3d , (CH 2 ) n N(R 3c )C(O)R 3d , (CH 2 ) n OC(O)R 3d , (CH 2 ) n C(O)OR 3d , (CH 2 ) n C(O)N(R 3c )R 3d , (CH 2 ) n N(R 3c )C(O)N(R 3c )R 3d , (CH 2 ) n SO 2 N(R 3c )R 3d , (CH 2 ) n N(R 3c )SO 2 R 3d , (CH 2 ) n N(R 3c )P(O)(R 3d ) 2 , (CH 2 ) n P(O)(N(R 3c R 3d )) 2 , and poly(ethylene oxide), wherein two geminal R 6  groups may together form a carbonyl; or any two or more R 6  groups together form a ring, or R 3b  and one or more R 6  groups together for a ring; and n in each case is independently selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10; wherein m is independently selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; R 7  is in each case independently selected from hydrogen, halogen, hydroxyl, amino, nitro, cyano, isocyano, (CH 2 ) n OR 3d , (CH 2 ) n SR 3d , (CH 2 ) n S(O)R 3d , (CH 2 ) n SO 2 R 3d (CH 2 ) n N(R 3c )R 3d , (CH 2 ) n C(O)R 3d , (CH 2 ) n N(R 3c )C(O)R 3d , (CH 2 ) n OC(O)R 3d , (CH 2 ) n C(O)OR 3d , (CH 2 ) n C(O)N(R 3c )R 3d , (CH 2 ) n N(R 3c )C(O)N(R 3c )R 3d , (CH 2 ) n SO 2 N(R 3c )R 3d , (CH 2 ) n  N(R 3c )SO 2 R 3d , (CH 2 ) n N(R 3c )P(O)(R 3d ) 2 , (CH 2 ) n P(O)(N(R 3c R 3d )) 2 , and poly(ethylene oxide); or two geminal R 7  groups together form a carbonyl; or R 7  groups on adjacent carbon atoms form a double or triple bond; or any two or more R 7  groups together form a ring, or R 3b  and one or more R 7  groups together form a ring.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 91.0
- Lexical Diversity: 1.43333
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15501613', '15619671', '14204076', '14977508', '14633360']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7379162244878101
- 35 USC 102 Novelty (BERT): 0.5423392808708645
- Combined Prediction Score: 0.7183585301261156
- Mean Citation Score: 311.770436
- Max Citation Score: 366.1146
- Similarity Product: 249.9394682345152

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test