PATENT CLAIM ANALYSIS

Application Number: 15865983
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["435", "006100"]

Abstract:
The present disclosure relates to chimeric antisense nucleotides and methods for modulating protein expression levels and/or RNA stability from at least two target mRNAs in a cell simultaneously.

Claim (Index 11):
A method for modulating protein expression levels or mRNA expression levels from at least two target mRNAs in a cell simultaneously, the method comprising:\n transforming the cell with a system for measuring the activity of a chimeric nucleic acid, the system comprising:\n a first plasmid comprising a chimeric nucleic acid, wherein the chimeric nucleic acid comprises a first nucleic acid sequence operably linked to a second nucleic acid sequence; \n a second plasmid comprising a first reporter gene operably linked to a first gene leader sequence; and \n a third plasmid comprising a second reporter gene operably linked to a second gene leader sequence; \n wherein the first nucleic acid sequence is present in a first fingerloop stem loop and the second nucleic acid sequence is present in a second fingerloop stem loop; \n wherein the first and second fingerloop stem loops inhibit the binding of the first and second nucleic acids to mismatched target sequences; \n wherein an sRNA of the first nucleic acid sequence binds to an mRNA of the first gene leader sequence and an sRNA of the second nucleic acid sequence binds to an mRNA of the second gene leader sequence; and \n measuring the protein expression levels or mRNA expression levels of the first reporter gene and the second reporter gene.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.0
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11107335', '14371557', '11104705', '13328447', '15317939']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6405168375590157
- 35 USC 102 Novelty (BERT): 0.5306432531024131
- Combined Prediction Score: 0.6295294791133554
- Mean Citation Score: 325.9496460000001
- Max Citation Score: 374.45648
- Similarity Product: 271.07706605203634

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test