PATENT CLAIM ANALYSIS

Application Number: 16165343
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "04400A"]

Abstract:
One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene. The dsRNA duplex comprises one or more motifs of three identical modifications on three consecutive nucleotides in one or both strand, particularly at or near the cleavage site of the strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.

Claim (Index 14):
The double-stranded RNAi agent of  claim 1 , wherein the modifications on the nucleotides are selected from the group consisting of 2\u2032-O-methyl nucleotide, 2\u2032-deoxyfluoro nucleotide, 2\u2032-O\u2014N-methylacetamido (2\u2032-O-NMA) nucleotide, a 2\u2032-O-dimethylaminoethoxyethyl (2\u2032-O-DMAEOE) nucleotide, 2\u2032-O-aminopropyl (2\u2032-O-AP) nucleotide, 2\u2032-ara-F, and combinations thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.61905
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14358009', '14419211', '15110658', '14358972', '14650128']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8319651348975046
- 35 USC 102 Novelty (BERT): 0.5987681592267206
- Combined Prediction Score: 0.8086454373304262
- Mean Citation Score: 443.76519400000006
- Max Citation Score: 499.7528400000001
- Similarity Product: 488.70605248652464

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test