PATENT CLAIM ANALYSIS

Application Number: 16016912
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["424", "186100"]

Abstract:
The present invention relates to a compound inducing activation of HLA-E-restricted CD8 T cells and/or NK cells in a human subject, and reducing HIV viral load, such as glatiramer acetate and glatiramer acetate related active substances and products, for use in the treatment of HIV infection. Macaques chronically infected by SIV have been treated with glatiramer acetate. One of the animals had already progressed to the stage of AIDS. We injected 18 mg of glatiramer acetate three times per week for only 2 weeks. Surprisingly, a strong impact on viral load was observed in response to the treatment. Viremia decreased by 1 log during glatiramer acetate treatment. Even more surprising was the fact that this decrease persisted after stopping the treatment reaching almost a 2 logs decrease in one animal. This is a major result as compared to cART as stopping cART leads to a rebound of the viral load within days. This decrease was correlated with activation of HLA-E restricted CD8 T cells, but not to other classical CD8+ T cells.

Claim (Index 19):
The method of  claim 18 , wherein the plasma sample is subjected to ultracentrifugation prior to preparing RNA.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 94.0
- Lexical Diversity: 1.67568
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14009250', '13452344', '14617711', '14386940', '14735662']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7405301044853895
- 35 USC 102 Novelty (BERT): 0.5202062650854431
- Combined Prediction Score: 0.7184977205453948
- Mean Citation Score: 263.715556
- Max Citation Score: 281.1796
- Similarity Product: 163.4159700695753

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test