PATENT CLAIM ANALYSIS

Application Number: 16046696
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "241000"]

Abstract:
Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor.

Claim (Index 4):
The method of  claim 1  wherein the bacterial efflux pump inhibitor is a compound of formula IV: or a pharmaceutically acceptable salt thereof, wherein: one of A\u2032 or B\u2032 is \u2014C(\u2550O)N(R a1 )\u2014R 1C , \u2014(C 1 -C 3 )alkyl-C(\u2550O)N(R a1 )R 1C , \u2014(C 1 -C 3 )alkyl-O\u2014R 1C , \u2014O\u2014R 1C , \u2014(C 1 -C 3 )alkyl-N(R a1 )\u2014R 1C , \u2014N(R a1 )\u2014R 1C , or R 1C  and the other of A\u2032 or B\u2032 is H, halogen, or (C 1 -C 4 )alkyl; each R 1C  is independently: (a) (C 1 -C 14 )alkyl substituted with one or more groups selected from the group consisting of \u2014NR b2 R c2 , \u2014NHNH 2 , \u2014C(\u2550NR a2 )(NR b2 R c2 ), \u2014NR a2 C(\u2550NR a2 )(R d2 ), and \u2014NR a2 C(\u2550NR a2 )(NR b2 R c2 ); and wherein (C 1 -C 14 )alkyl is optionally substituted independently with one or more halo, (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; or (b) (C 3 -C 7 )carbocyclyl, (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl-, 4-7 membered monocyclic heterocyclyl, 4-7 membered monocyclic heterocyclyl-(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl-NR e \u2014(C 1 -C 4 )alkyl- or 4-7 membered monocyclic heterocyclyl-NR e \u2014(C 1 -C 4 )alkyl- wherein each (C 3 -C 7 )carbocyclyl, (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl- or \u2014(C 3 -C 7 )carbocyclyl-NR e \u2014(C 1 -C 4 )alkyl- is independently substituted with one or more Z 1  or Z 2 , and wherein each 4-7 membered monocyclic heterocyclyl, 4-7 membered monocyclic heterocyclyl-(C 1 -C 4 )alkyl- or 4-7 membered monocyclic heterocyclyl-NR e \u2014(C 1 -C 4 )alkyl- is independently optionally substituted with one or more Z 1  or Z 2 , and wherein any (C 3 -C 7 )carbocyclyl, (C 3 -C 7 )carbocyclyl-(C 1 -C 4 )alkyl-, 4-7 membered monocyclic heterocyclyl, 4-7 membered monocyclic heterocyclyl-(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl NR e \u2014(C 1 -C 4 )alkyl- or 4-7 membered monocyclic heterocyclyl-NR e \u2014(C 1 -C 4 )alkyl- of R 1  is independently optionally substituted with one or more halo, (C 1 -C 4 )alkyl, (C 3 -C 7 )carbocyclyl, \u2014C(\u2550O)NH 2 , \u2014C(\u2550O)NH(C 1 -C 4 )alkyl, \u2014C(\u2550O)N((C 1 -C 4 )alkyl) 2 , \u2014NHC(\u2550O)(C 1 -C 4 )alkyl-NH 2 , or 3-7 membered monocyclic heterocyclyl wherein (C 1 -C 4 )alkyl, (C 3 -C 7 )carbocyclyl or 3-7 membered monocyclic heterocyclyl is optionally substituted with one or more halogen, (C 1 -C 4 )alkyl, \u2014NH 2 , \u2014NH(C 1 -C 4 )alkyl or \u2014N((C 1 -C 4 )alkyl) 2 ; R 2C  is hydrogen, (C 1 -C 4 )alkyl or phenyl(C 1 -C 3 )alkyl-, wherein the phenyl is optionally substituted with one or more (C 1 -C 4 )alkyl, \u2014O(C 1 -C 4 )alkyl, halogen, or \u2014NO 2 ; R 3C  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl, or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, \u2014OH, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, and (C 1 -C 4 )haloalkoxy; R 4C  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl, heteroaryl, aryl(C 1 -C 4 )alkyl-, heteroaryl(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl(C 2 -C 4 )alkynyl-, phenoxy or heteroaryloxy, wherein the aryl, heteroaryl, aryl(C 1 -C 4 )alkyl-, heteroaryl(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl(C 2 -C 4 )alkynyl-, phenoxy or heteroaryloxy, is optionally substituted with one or more groups independently selected from the group consisting of halo, \u2014OH, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, methylenedioxy (\u2014OCH 2 O\u2014), and (C 3 -C 7 )carbocyclyl; R 5C  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl, heteroaryl aryl(C 1 -C 4 )alkyl-, heteroaryl(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl(C 2 -C 4 )alkynyl-, phenoxy or heteroaryloxy, wherein the aryl, heteroaryl, aryl(C 1 -C 4 )alkyl-, heteroaryl(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl(C 1 -C 4 )alkyl-, (C 3 -C 7 )carbocyclyl(C 2 -C 4 )alkynyl-, phenoxy or heteroaryloxy, is optionally substituted with one or more groups independently selected from the group consisting of halo, \u2014OH, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, methylenedioxy (\u2014OCH 2 O\u2014), and (C 3 -C 7 )carbocyclyl; R 6C  is hydrogen, halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, aryl, or heteroaryl wherein the aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, \u2014OH, \u2014NO 2 , \u2014CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )alkoxy, and (C 1 -C 4 )haloalkoxy; each Z 1  is independently selected from the group consisting of \u2014NR b3 R c3 , \u2014NHNH 2 , \u2014C(\u2550NR a3 )(NR b3 R c3 ), \u2014NR a3 C(\u2550NR a3 )(R d3 ), and \u2014NR a3 C(\u2550NR a3 )(NR b3 R c3 ); each Z 2  is independently \u2014(C 1 -C 6 )alkyl substituted with one or more Z 1  and optionally substituted with one or more Z 3 ; each Z 3  is independently halo or (C 3 -C 7 )carbocyclyl; each R a1  is independently hydrogen, (C 1 -C 4 )alkyl, (C 3 -C 7 )carbocyclyl or 3-7 membered monocyclic heterocyclyl optionally substituted with one or more halogen or (C 1 -C 4 )alkyl; each R a2  is independently hydrogen, (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; each R b2  and R c2  is independently hydrogen, (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; R d2  is (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; each R a3  is independently hydrogen (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; each R b3  and R 3  is independently hydrogen (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; R d3  is (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl; and each R e  is independently hydrogen, (C 1 -C 4 )alkyl or (C 3 -C 7 )carbocyclyl.

Metadata:
- Claim Count in Document: 25.0
- Percentile: 95.0
- Lexical Diversity: 1.75
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15066911', '15323081', '15296601', '11791928', '13066616']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8321052727768574
- 35 USC 102 Novelty (BERT): 0.5454524420160869
- Combined Prediction Score: 0.8034399897007803
- Mean Citation Score: 388.26477400000016
- Max Citation Score: 418.62888
- Similarity Product: 281.38704752231604

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test