PATENT CLAIM ANALYSIS

Application Number: 16068272
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "255050"]

Abstract:
Provided herein are compounds of the formula I: as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment or prevention of mGluR5 mediated disorders, such as acute and/or chronic neurological disorders, cognitive disorders and memory deficits, as well as acute and chronic pain.

Claim (Index 1):
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: one of A and B is CR, and the other is N; R is \u2014H, -halogen, -alkyl, -cycloalkyl, -haloalkyl, \u2014OR 2 , or \u2014N(CH 3 ) 2 , wherein R 2  is lower alkyl which may be optionally substituted with 1-3 substituents selected from the group consisting of -halogen, \u2014OH, -alkoxy, and \u2014N(CH 3 ) 2 ; R 1  is \u2014H, -halogen, -alkyl, -cycloalkyl, -haloalkyl, \u2014OR 2\u2032 , or \u2014N(CH 3 ) 2 , wherein R 2\u2032  is lower alkyl which may be optionally substituted with 1-3 substituents selected from the group consisting of -halogen, \u2014OH, -alkoxy, and \u2014N(CH 3 ) 2 ; Ar 1  is a 5- to 10-membered mono- or bicyclic heteroaryl ring that contains 1-3 heteroatoms selected from the group consisting of N, O and S, wherein the 5- to 10-membered mono- or bicyclic heteroaryl ring is optionally substituted with 1-3 substituents independently selected from the group consisting of -alkyl, -halogen, \u2014OH, \u2014CN, nitro, \u2014CF 3 , \u2014O\u2014CF 3 , \u2014O-alkyl, \u2014O-aryl, \u2014S-alkyl, \u2014S-aryl, \u2014S(O)-alkyl, \u2014S(O)-aryl, \u2014S(O 2 )-alkyl, \u2014S(O 2 )-aryl, \u2014CH 2 -aryl, aryl, heteroaryl, \u2014O\u2014CH 2 -aryl, \u2014N(CH 3 ) 2 , cycloalkyl, heterocycloalkyl, \u2014C(O)\u2014 alkyl, \u2014C(O)-cycloalkyl, \u2014C(O)-heterocycloalkyl, \u2014C(O)-aryl, \u2014C(O)-heteroaryl, \u2014C(O)O\u2014 alkyl, \u2014C(O)O-cycloalkyl, \u2014C(O)O-heterocycloalkyl, \u2014C(O)O-aryl, \u2014C(O)O-heteroaryl, \u2014C(O)NH 2 , \u2014C(O)NH-alkyl, \u2014C(O)N(alkyl) 2 , \u2014C(O)NH-cycloalkyl, \u2014C(O)N(cycloalkyl) 2 , \u2014C(O)NH-heterocycloalkyl, \u2014C(O)N(heterocycloalkyl) 2 , \u2014C(O)NH-aryl, \u2014C(O)N(aryl) 2 , \u2014C(O)NH-heteroaryl, \u2014C(O)N(heteroaryl) 2 , and substituted lower alkyl, wherein the substituents may combine to form an optionally substituted 5-7 membered fused carbacyclic or heterocyclic ring, or\n a 5- to 10-membered mono- or bicyclic aryl ring, wherein the 5- to 10-membered mono- or bicyclic aryl ring is optionally substituted with 1-3 substituents independently selected from the group consisting of -alkyl, -halogen, \u2014OH, \u2014CN, nitro, \u2014CF 3 , \u2014O\u2014CF 3 , \u2014O-alkyl, \u2014O-aryl, \u2014S-alkyl, \u2014S-aryl, \u2014S(O)-alkyl, \u2014S(O)-aryl, \u2014S(O 2 )-alkyl, \u2014S(O 2 )-aryl, \u2014CH 2 -aryl, aryl, heteroaryl, \u2014O\u2014CH 2 -aryl, \u2014N(CH 3 ) 2 , cycloalkyl, heterocycloalkyl, \u2014C(O)-alkyl, \u2014C(O)-cycloalkyl, \u2014C(O)-heterocycloalkyl, \u2014C(O)-aryl, \u2014C(O)-heteroaryl, \u2014C(O)O-alkyl, \u2014C(O)O-cycloalkyl, \u2014C(O)O-heterocycloalkyl, \u2014C(O)O-aryl, \u2014C(O)O-heteroaryl, \u2014C(O)NH 2 , \u2014C(O)NH-alkyl, \u2014C(O)N(alkyl) 2 , \u2014C(O)NH-cycloalkyl, \u2014C(O)N(cycloalkyl) 2 , \u2014C(O)NH-heterocycloalkyl, \u2014C(O)N(heterocycloalkyl) 2 , \u2014C(O)NH-aryl, \u2014C(O)N(aryl) 2 , \u2014C(O)NH-heteroaryl, \u2014C(O)N(heteroaryl) 2 , and substituted lower alkyl, wherein the substituents may combine to form a 5-7 membered fused and optional substituted carbacyclic or heterocyclic ring; \n Ar 2  is a 5- to 10-membered mono- or bicyclic heteroaryl ring that contains 1-3 heteroatoms independently selected from the group consisting of N, O and S, wherein the 5- to 10-membered mono- or bicyclic heteroaryl ring is optionally substituted with 1-3 substituents independently selected from the group consisting of -alkyl, -halogen, \u2014OH, \u2014CN, nitro, \u2014CF 3 , \u2014O\u2014CF 3 , \u2014O-alkyl, \u2014O-aryl, \u2014S-alkyl, \u2014S-aryl, \u2014S(O)-alkyl, \u2014S(O)-aryl, \u2014S(O 2 )-alkyl, \u2014S(O 2 )-aryl, \u2014O-alkyl-OH, \u2014O-alkyl-O-alkyl, \u2014CH 2 -aryl, aryl, heteroaryl, \u2014O\u2014CH 2 -aryl, \u2014N(CH 3 ) 2 , cycloalkyl, heterocycloalkyl, \u2014C(O)-alkyl, \u2014C(O)-cycloalkyl, \u2014C(O)\u2014 heterocycloalkyl, \u2014C(O)-aryl, \u2014C(O)-heteroaryl, \u2014C(O)O-alkyl, \u2014C(O)O-cycloalkyl, \u2014C(O)O-heterocycloalkyl, \u2014C(O)O-aryl, \u2014C(O)O-heteroaryl, \u2014C(O)NH 2 , \u2014C(O)NH-alkyl, \u2014C(O)N(alkyl) 2 , \u2014C(O)NH-cycloalkyl, \u2014C(O)N(cycloalkyl) 2 , \u2014C(O)NH-heterocycloalkyl, \u2014C(O)N(heterocycloalkyl) 2 , \u2014C(O)NH-aryl, \u2014C(O)N(aryl) 2 , \u2014C(O)NH-heteroaryl, \u2014C(O)N(heteroaryl) 2 , and substituted lower alkyl wherein the substituents may combine to form an optionally substituted 5-7 membered fused carbacyclic or heterocyclic ring, or\n a 5- to 10-membered mono- or bicyclic aryl ring, wherein the 5- to 10-membered mono- or bicyclic aryl ring is optionally substituted with 1-3 substituents independently selected from the group consisting of -alkyl, -halogen, \u2014OH, \u2014CN, nitro, \u2014CF 3 , \u2014O\u2014CF 3 , \u2014O-alkyl, \u2014O-aryl, \u2014S-alkyl, \u2014S-aryl, \u2014S(O)-alkyl, \u2014S(O)-aryl, \u2014S(O 2 )-alkyl, \u2014S(O 2 )-aryl, \u2014O-alkyl-OH, \u2014O-alkyl-O-alkyl, \u2014CH 2 -aryl, aryl, heteroaryl, \u2014O\u2014CH 2 -aryl, \u2014N(CH 3 ) 2 , cycloalkyl, heterocycloalkyl, \u2014C(O)-alkyl, \u2014C(O)-cycloalkyl, \u2014C(O)-heterocycloalkyl, \u2014C(O)-aryl, \u2014C(O)-heteroaryl, \u2014C(O)O-alkyl, \u2014C(O)O-cycloalkyl, \u2014C(O)O-heterocycloalkyl, \u2014C(O)O-aryl, \u2014C(O)O-heteroaryl, \u2014C(O)NH 2 , \u2014C(O)NH-alkyl, \u2014C(O)N(alkyl) 2 , \u2014C(O)NH\u2014 cycloalkyl, \u2014C(O)N(cycloalkyl) 2 , \u2014C(O)NH-heterocycloalkyl, \u2014C(O)N(heterocycloalkyl) 2 , \u2014C(O)NH-aryl, \u2014C(O)N(aryl) 2 , \u2014C(O)NH-heteroaryl, \u2014C(O)N(heteroaryl) 2 , and substituted lower alkyl wherein the substituents may combine to form an optionally substituted 5-7 membered fused carbacyclic or heterocyclic ring.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 95.0
- Lexical Diversity: 1.56522
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16091781', '15771920', '11360085', '11726807', '14344957']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8434522186546258
- 35 USC 102 Novelty (BERT): 0.5595553445392712
- Combined Prediction Score: 0.8150625312430904
- Mean Citation Score: 373.213428
- Max Citation Score: 444.10822
- Similarity Product: 373.5794643374908

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test