PATENT CLAIM ANALYSIS

Application Number: 15751943
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "469000"]

Abstract:
Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein.

Claim (Index 1):
A compound of Formula (II): or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is hydrogen, halogen, or optionally substituted alkyl; \n each instance of R 3  is independently halogen, \u2014CN, \u2014NO 2 , \u2014N 3 , optionally substituted alkyl, \u2014OR 3A , \u2014N(R 3B ) 2 , or optionally substituted acyl; \n n is 0, 1, 2, 3, 4, or 5; \n R 4  is hydrogen, optionally substituted alkyl, or a nitrogen protecting group; \n R 5  is halogen or optionally substituted C 1-6  alkyl; \n each of R 2  and R 3A  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or an oxygen protecting group; and \n each instance of R 3B  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group, or two R 3B  are taken together with the intervening atoms to form optionally substituted heterocyclyl; \n R 6  is hydrogen, halogen, \u2014CN, \u2014NO 2 , \u2014N 3 , optionally substituted alkyl, \u2014OR 6A , \u2014N(R 6B ) 2 , or optionally substituted acyl; \n R 6A  is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or an oxygen protecting group; and \n each instance of R 6B  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group, or two R 6B  are taken together with the intervening atoms to form optionally substituted heterocyclyl.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 88.0
- Lexical Diversity: 1.7971
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['16095188', '15327705', '15737683', '15737535', '15327690']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8359812650777867
- 35 USC 102 Novelty (BERT): 0.565268781309646
- Combined Prediction Score: 0.8089100167009726
- Mean Citation Score: 449.84217
- Max Citation Score: 452.49582
- Similarity Product: 349.5155487262129

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test