PATENT CLAIM ANALYSIS

Application Number: 15896536
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["424", "094630"]

Abstract:
Disclosed herein are compositions and methods for treating celiac sprue.

Claim (Index 1):
A method of degrading gliadin in a meal ingested by an individual in need of such treatment, said method comprising the step of orally administering to said individual a therapeutically effective dose of a pharmaceutical composition comprising a polypeptide comprising an amino acid sequence at least 85% identical to the amino acid sequence of SEQ ID NO:35 residues 1-378, and a pharmaceutically acceptable carrier; wherein\n (a) the polypeptide degrades a PQPQLP (SEQ ID NO:34) peptide at pH 4; (b) residue 278 is Ser, residue 78 is Glu, and residue 82 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 67 residues 1-378 at one or more residues selected from the group consisting of amino acid residues 73, 102, 103, 104, 130, 165, 168, 169, 172, and 179; wherein said treatment reduces exposure of said individual to immunogenic gliadin peptides.

Metadata:
- Claim Count in Document: 104.0
- Percentile: 88.0
- Lexical Diversity: 1.0
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15633065', '14131601', '15006341', '14911630', '14459060']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7760039436768793
- 35 USC 102 Novelty (BERT): 0.6369911617134927
- Combined Prediction Score: 0.7621026654805406
- Mean Citation Score: 526.893194
- Max Citation Score: 677.80835
- Similarity Product: 524.7800863026947

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test