PATENT CLAIM ANALYSIS

Application Number: 16242139
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["514", "471000"]

Abstract:
The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Claim (Index 1):
A method of treating a cardiovascular disease responsive to nitroxyl therapy, comprising intravenously administering an effective amount of a compound of formula (3), or a pharmaceutical composition comprising the compound of formula (3), to a patient in need thereof, wherein the compound of formula (3) is represented by formula: wherein R is hydrogen, \u2014(C 1 -C 6 )alkyl, \u2014(C 2 -C 4 )alkenyl, phenyl, benzyl, cyclopentyl, cyclohexyl, \u2014(C 5 -C 7 )heterocycloalkyl, benzyloxy, \u2014O\u2014(C 1 -C 6 )alkyl, \u2014NH 2 , \u2014NH\u2014(C 1 -C 4 )alkyl, or \u2014N((C 1 -C 4 )alkyl) 2 , wherein said \u2014(C 1 -C 6 )alkyl, \u2014(C 2 -C 4 )alkenyl, phenyl, benzyl, cyclopentyl, cyclohexyl, \u2014(C 5 -C 7 )heterocycloalkyl, benzyloxy, \u2014O\u2014(C 1 -C 6 )alkyl, \u2014NH\u2014(C 1 -C 4 )alkyl, or \u2014N((C 1 -C 4 )alkyl) 2  can be unsubstituted or substituted with one or more substituents selected from halo, \u2014(C 1 -C 6 )alkyl, \u2014(C 2 -C 4 )alkenyl, \u2014(C 2 -C 3 )alkynyl, -(5- or 6-membered)heteroaryl, \u2014O\u2014(C 1 -C 6 )alkyl, \u2014S\u2014(C 1 -C 6 )alkyl, \u2014C(halo) 3 , \u2014CH(halo) 2 , \u2014CH2(halo), \u2014CN, \u2014NO 2 , \u2014NH 2 , \u2014NH\u2014(C 1 -C 4 )alkyl, \u2014N(\u2014(C 1 -C 4 )alkyl) 2 , \u2014C(\u2550O )(C 1 -C 4 )alkyl, \u2014C(\u2550O )O(C 1 -C 4 )alkyl, \u2014OC(\u2550O)(C 1 -C 4 )alkyl, \u2014OC(\u2550O)NH 2 , \u2014S(\u2550O)(C 1 -C 4 )alkyl, or \u2014S(\u2550O) 2 (C 1 -C 4 )alkyl; and wherein the compound or the pharmaceutical composition is administered at a dose of at least 1 \u03bcg/kg/min.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 99.0
- Lexical Diversity: 1.75
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14641377', '14880173', '15430946', '15960993', '14158456']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7893037276072065
- 35 USC 102 Novelty (BERT): 0.53508773905924
- Combined Prediction Score: 0.7638821287524098
- Mean Citation Score: 372.280226
- Max Citation Score: 388.42148
- Similarity Product: 277.0012830828643

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test