PATENT CLAIM ANALYSIS

Application Number: 15754311
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "263220"]

Abstract:
The invention relates generally to compounds of formula (I) that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Claim (Index 2):
A compound according to  claim 1  of formula II wherein:\n R 1  is aryl or heteroaryl, substituted with 0-3 R 5 ; \n R 2  is hydrogen, halogen or NHCOR 6 ; \n R 3  is hydrogen, halogen, \u2014CONR 7 R 8  or \u2014OR 9 ; \n R x  is hydrogen, halogen, (C 1 -C 6 ) alkyl or \u2014NHCOR 6 ; \n R 4  is hydrogen, halogen, (C 1 -C 6 ) alkyl, (C 3 -C 8 ) cycloalkyl, \u2014CONHR 10  or \u2014NHR 11 R 12 ; \n R y  is hydrogen, benzyl or (C 3 -C 8 ) cycloalkyl; \n R 5  is hydrogen, halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, \u2014NH 2  or NHSO 2 (C 1 -C 6 )alkyl; \n R 6  is (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl or hydroxy (C 1 -C 6 )alkyl; \n R 7  is hydrogen or (C 1 -C 6 ) alkyl; \n R 8  is hydrogen or (C 1 -C 6 ) alkyl; or \n R 7  and R 8  are taken together with the nitrogen to which they are attached to form a 5-8 membered heterocyclic group optionally with one or more additional heteroatoms selected from \u2014N\u2014, \u2014O\u2014 or \u2014S\u2014; \n R 9  is (C 1 -C 6 )alkyl; \n R 10  is hydrogen or (C 1 -C 6 ) alkyl; \n R 11  is hydrogen or (C 1 -C 6 ) alkyl; \n R 12  is hydrogen or (C 1 -C 6 ) alkyl; \n or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 88.0
- Lexical Diversity: 1.41176
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15747843', '14977709', '15746597', '15755636', '12663504']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7996830523704392
- 35 USC 102 Novelty (BERT): 0.5312403293825115
- Combined Prediction Score: 0.7728387800716465
- Mean Citation Score: 308.121634
- Max Citation Score: 358.2882
- Similarity Product: 300.1711297319412

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test