PATENT CLAIM ANALYSIS

Application Number: 16205205
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-04
Patent Classification: ["424", "191100"]

Abstract:
Disclosed herein are non-myeloablative antibody-toxin conjugates and compositions that target cell surface markers, such as the CD34, CD45 or CD117 receptors, and related methods of their use to effectively conditioning a subject's tissues (e.g., bone marrow tissue) prior to engraftment or transplant. The compositions and methods disclosed herein may be used to condition a subject's tissues in advance of, for example, hematopoietic stem cell transplant and advantageously such compositions and methods do not cause the toxicities that are commonly associated with traditional conditioning methods.

Claim (Index 1):
A method of conditioning a subject for engraftment, the method comprising selectively depleting or ablating an endogenous hematopoietic stem cell (HSC) or progenitor cell population in a target tissue of an immunocompetent subject comprising administering to the subject an effective amount of an antibody coupled to a toxin,\n wherein:\n the antibody binds to CD117; \n the method does not induce anemia in the subject; and \n the toxin is internalized by an endogenous HSC or progenitor cell population, thereby depleting or ablating the endogenous hematopoietic stem cell or progenitor cell population in the target tissue.

Metadata:
- Claim Count in Document: 43.0
- Percentile: 98.0
- Lexical Diversity: 1.47692
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15148837', '15504264', '15211679', '14800474', '14799328']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6889081573953398
- 35 USC 102 Novelty (BERT): 0.6767928679206344
- Combined Prediction Score: 0.6876966284478694
- Mean Citation Score: 398.897926
- Max Citation Score: 704.1681
- Similarity Product: 641.3752207437694

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test