PATENT CLAIM ANALYSIS

Application Number: 15897598
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-11
Patent Classification: ["514", "210210"]

Abstract:
The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Claim (Index 3):
The method of  claim 1 , wherein the compound of Formula I is a compound of Formula Ia: or a pharmaceutically acceptable salt thereof; wherein:\n X is N or CR 4 ; \n W is N or CR 6 ; \n Y is N or CH; \n R 1  is C 1-6  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-3  alkyl, 4-6 membered heterocycloalkyl, or 4-6 membered heterocycloalkyl-C 1-3  alkyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from fluoro, chloro, C 1-3  alkyl, \u2014OH, \u2014O(C 1-3  alkyl), \u2014CN, \u2014CF 3 , \u2014CHF 2 , \u2014CH 2 F, \u2014NH 2 , \u2014NH(C 1-3  alkyl), \u2014N(C 1-3  alkyl) 2 , \u2014C(\u2550O)N(C 1-3  alkyl) 2 , \u2014C(\u2550O)NH(C 1-3  alkyl), \u2014C(\u2550O)NH 2 , \u2014C(\u2550O)O(C 1-3  alkyl), \u2014S(\u2550O) 2 (C 1-3  alkyl), \u2014S(\u2550O) 2 (C 3-6  cycloalkyl), \u2014C(\u2550O)(C 3-6  cycloalkyl), and \u2014C(\u2550O)(C 1-3  alkyl); \n R 2  is H or C 1-3  alkyl; wherein said C 1-3  alkyl is optionally substituted by 1, 2, or 3 substituents independently selected from fluoro, chloro, \u2014OH, \u2014O(C 1-3  alkyl), \u2014CN, \u2014CF 3 , \u2014CHF 2 , \u2014CH 2 F, NH 2 , \u2014NH(C 1-3  alkyl), and \u2014N(C 1-3  alkyl) 2 ; or \n R 1  and R 2 , together with the nitrogen atom to which they are attached, form a 4-, 5- or 6-membered heterocycloalkyl ring, which is optionally substituted with 1, 2, or 3 substitutents independently selected from fluoro, \u2014OH, \u2014O(C 1-3  alkyl), \u2014CN, C 1-3  alkyl, C 1-3  haloalkyl, \u2014NH 2 , \u2014NH(C 1-3  alkyl), \u2014N(C 1-3  alkyl) 2 , and \u2014CH 2 CN; \n R 3  is H, F, Cl, \u2014CN, C 1-3  alkyl, \u2014OCF 3 , \u2014CF 3 , or \u2014O(C 1-3  alkyl); \n R 4  is H, F, Cl, \u2014CN, C 1-3  alkyl, or \u2014O(C 1-3  alkyl); \n R 5  is H, F, Cl, \u2014CN, C 1-3  alkyl, or \u2014O(C 1-3  alkyl); \n R 6  is H, F, Cl, \u2014CN, or C 1-3  alkyl; \n R 7  is H, F, Cl, C 1-3  alkyl, C 1-3  haloalkyl, \u2014NR 17 R 17a , \u2014NHC(\u2550O)R 17b , \u2014C(\u2550O)NR 17a R 17b , \u2014NHS(\u2550O) 2 R 17b , or \u2014S(\u2550O) 2 NR 17a R 17b , wherein said C 1-3  alkyl is optionally substituted with 1, 2, or 3 substituents selected from F, Cl, \u2014CN, \u2014CF 3 , \u2014CHF 2 , \u2014CH 2 F, \u2014NH 2 , and OH; \n R 8  is H, F, Cl, C 1-3  alkyl, or C 1-3  haloalkyl; \n R 9  is H, F, Cl, C 1-3  alkyl, C 1-3  haloalkyl, cyclopropyl, \u2014CN, \u2014NH 2 , \u2014NH(C 1-3  alkyl), or \u2014N(C 1-3  alkyl) 2 , wherein said C 1-3  alkyl is optionally substituted with 1, 2, or 3 substituents selected from F, chloro, \u2014CN, \u2014CF 3 , \u2014CHF 2 , \u2014CH 2 F, \u2014NH 2 , and OH; \n R 10  is H, F, Cl, C 1-3  alkyl, C 1-3  haloalkyl, cyclopropyl, \u2014CN, \u2014NH 2 , \u2014NH(C 1-3  alkyl), or \u2014N(C 1-3  alkyl) 2 , wherein said C 1-3  alkyl is optionally substituted with 1, 2, or 3 substituents selected from F, chloro, \u2014CN, \u2014CF 3 , \u2014CHF 2 , \u2014CH 2 F, \u2014NH 2 , and OH; \n R 17  is C 1-6  alkyl, phenyl or 5-6 membered heteroaryl, each of which is optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 27 ; \n R 17a  is H or C 1-3  alkyl; \n R 17b  is C 1-3  alkyl optionally substituted with 1, 2, or 3 substituents selected from F, chloro, \u2014CN, \u2014CF 3 , \u2014CHF 2 , \u2014CH 2 F, \u2014NH 2 , and OH and \n each R 27  is independently selected from halo, \u2014OH, NO 2 , \u2014CN, C 1-3  alkyl, C 2-3  alkenyl, C 2-3  alkynyl, C 1-3  haloalkyl, cyano-C 1-3  alkyl, HO\u2014C 1-3  alkyl, CF 3 \u2014C 1-3  hydroxyalkyl, C 1-3  alkoxy-C 1-3  alkyl, C 3-7  cycloalkyl, C 1-3  alkoxy, C 1-3  haloalkoxy, H 2 N\u2014, (C 1-3  alkyl)NH\u2014, (C 1-3  alkyl) 2 N\u2014, HS\u2014, C 1-3  alkyl-S\u2014, C 1-3  alkyl-S(\u2550O)\u2014, C 1-3  alkyl-S(\u2550O) 2 \u2014, carbamyl, C 1-3  alkylcarbamyl, di(C 1-3  alkyl)carbamyl, carboxy, C 1-3  alkyl-C(\u2550O)\u2014, C 1-4  alkoxy-C(\u2550O)\u2014, C 1-3  alkyl-C(\u2550O)O\u2014, C 1-3  alkyl-C(\u2550O)NH\u2014, C 1-3  alkyl-S(\u2550O) 2 NH\u2014, H 2 N\u2014SO 2 \u2014, C 1-3  alkyl-NH\u2014S(\u2550O) 2 \u2014, (C 1-3  alkyl) 2 N\u2014S(\u2550O) 2 \u2014, H 2 N\u2014S(\u2550O) 2 NH\u2014, C 1-3  alkyl-NHS(\u2550O) 2 NH\u2014, (C 1-3  alkyl) 2 N\u2014S(\u2550O) 2 NH\u2014, H 2 N\u2014C(\u2550O)NH\u2014, C 1-3  alkyl-NHC(\u2550O)NH\u2014, and (C 1-3  alkyl) 2 N\u2014C(\u2550O)NH\u2014.

Metadata:
- Claim Count in Document: 131.0
- Percentile: 88.0
- Lexical Diversity: 1.40426
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14279929', '14186338', '15187296', '14697236', '15435735']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7267135704285331
- 35 USC 102 Novelty (BERT): 0.6884595765919204
- Combined Prediction Score: 0.7228881710448718
- Mean Citation Score: 529.80984
- Max Citation Score: 691.5215
- Similarity Product: 677.6554709298609

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test