PATENT CLAIM ANALYSIS

Application Number: 15969525
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["435", "006120"]

Abstract:
A nucleic acid patch method for amplifying target nucleic acid sequences in circulating free DNA or residual DNA samples where the defining ends of the target nucleic acid sequences are unknown.

Claim (Index 1):
A system for the capture and amplification of a targeted region of fragmented deoxyribonucleic acid (fgDNA), the system comprising:\n a sample of an fgDNA having a targeted region between two unknown sequences reduced to a single stranded fgDNA; a plurality of oligonucleotide patches, each of which comprises:\n a nucleotide sequence complementary to an end of said targeted region; \n a universal primer sequence; and \n a protecting group on at least one end; \n wherein one of said oligonucleotide patches binding to each of said ends of said targeted region creating double stranded DNA at both said ends of said targeted region and leaving single stranded DNA flanking regions outside said targeted region, said single stranded DNA flanking regions being of unknown length and sequence; enzymes for cleaving said single stranded DNA flanking regions from said double stranded DNA at both said ends of said single stranded fgDNA, resulting in said single stranded fgDNA being reduced to targeted region with said double stranded DNA at both said ends said protecting group preventing said oligonucleotide patch from degradation by said enzymes; and a complementary universal primer ligated to each of said ends of said targeted region.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 93.0
- Lexical Diversity: 1.33333
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13794267', '13556590', '12555627', '15223792', '15316778']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5980650636185232
- 35 USC 102 Novelty (BERT): 0.5373092059651582
- Combined Prediction Score: 0.5919894778531868
- Mean Citation Score: 285.175358
- Max Citation Score: 387.03326
- Similarity Product: 340.7854916981792

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test