PATENT CLAIM ANALYSIS

Application Number: 15939231
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["435", "220000"]

Abstract:
The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.

Claim (Index 58):
A process for making a drug product consisting of isolated and purified collagenase I and collagenase II obtained or derived from  C. histolyticum  collagenase I and collagenase II, respectively, wherein the collagenase I and collagenase II have a mass ratio of about 1 to 1 and the drug product is at least 95% by area pure as determined by reverse phase high performance liquid chromatography, comprising the steps of:\n a. fermenting  C. histolyticum;  b. harvesting a crude fermentation comprising collagenase I and collagenase II; c. purifying collagenase I and collagenase II from the crude harvest via filtration and column chromatography comprising treating the collagenase I and collagenase II with an ammonium sulfate solution having a zinc level of less than about 80 ppm and a nickel level less than about 1.2 ppm.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 90.0
- Lexical Diversity: 1.3913
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12474488', '13515203', '11699302', '13422939', '14394481']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6295696334039613
- 35 USC 102 Novelty (BERT): 0.5153032946705352
- Combined Prediction Score: 0.6181429995306187
- Mean Citation Score: 300.109898
- Max Citation Score: 338.7013
- Similarity Product: 316.63968727839585

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test