PATENT CLAIM ANALYSIS

Application Number: 15904927
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-02
Patent Classification: ["544", "179000"]

Abstract:
The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.

Claim (Index 82):
A method of preparing a peptide, polypeptide or protein comprising incorporated therein a tetrazine-substituted amino acid unit comprising reacting a peptide, polypeptide or protein under peptide coupling conditions with a compound according the following formula (I-1): or a salt thereof, wherein: R N  is hydrogen or an amine protecting group; R C  is hydrogen or a carboxyl protecting group; provided that R N  is hydrogen or R C  is hydrogen; R 1  is hydrogen, (C 1 -C 6 )alkyl or substituted (C 1 -C 6 )alkyl; A is absent or is a group selected from groups of formulae (A1), (A2), (A3), (A4) and (A5): n1 is 1, 2, 3, 4, 5, or 6; n2 is 0, 1, 2, 3, 4, 5 or 6; a and b denote bonds attaching A to the remainder of the molecule or together form a single bond when A is absent.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 88.0
- Lexical Diversity: 1.21053
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14437905', '13982446', '13126660', '14889647', '15111138']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7518760339077716
- 35 USC 102 Novelty (BERT): 0.5580994882814847
- Combined Prediction Score: 0.732498379345143
- Mean Citation Score: 285.1857540000001
- Max Citation Score: 463.31192
- Similarity Product: 340.0620144369459

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test