PATENT CLAIM ANALYSIS

Application Number: 15981177
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["424", "094640"]

Abstract:
The present invention relates to variants of factor IX (F.IX) or activated factor IX (F.IXa), wherein the variant is characterized in that it has clotting activity in absence of its cofactor. The present invention furthermore relates to variants of factor IX (F.IX) or activated factor IX (F.IXa), wherein the variant is characterized in that it has increased F.IX clotting activity compared to wildtype. The present invention furthermore relates to the use of these variants for the treatment and/or prophylaxis of bleeding disorders, in particular hemophilia A and/or hemophilia B or hemophilia caused or complicated by inhibitory antibodies to F.VIII. The present invention also relates to further variants of factor IX (F.IX) which have desired properties and can, thus be tailored for respective specific therapeutic applications.

Claim (Index 10):
The variant factor IX of  claim 6  selected from\n variant V10K/R338L \n variant R338L/S377W \n variant V10K/R338L/S377W \n variant V10K/R338L/S377W/L6F \n variant V10K/R338L/S377W/E243D \n variant V10K/R338L/S377W/E224G \n variant V10K/R338L/S377W/L6F/E224G \n variant V10K/R338L/S377W/E243D/E224G \n variant V10K/R338L/S377W/K265T \n variant K5A/R338L \n variant K5A/R338L/S377W \n variant K5A/V10K/R338L/S377W \n variant G4Y/V86A/R338L/S377W and \n variant G4Y/V86A/R338L/S377W/K265T.

Metadata:
- Claim Count in Document: 31.0
- Percentile: 93.0
- Lexical Diversity: 2.10294
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15103183', '13001187', '10485696', '11734489', '14438571']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7935961348917819
- 35 USC 102 Novelty (BERT): 0.6121755163843016
- Combined Prediction Score: 0.7754540730410339
- Mean Citation Score: 487.13627
- Max Citation Score: 954.09717
- Similarity Product: 501.80946775336326

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test