PATENT CLAIM ANALYSIS

Application Number: 16093959
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["424", "187100"]

Abstract:
Increased viral particle maturation and production can be achieved in various methods for producing viral particles from viral proteins, in general, by inhibiting or preventing Heme Oxygenase 2 (HO-2) from binding to the group-specific antigen (Gag) of the viral proteins, thus allowing delivery of the viral proteins to plasma membranes where they can replicate and mature without interference from HO-2. The increase in viral particle maturation and production can also be achieved by minimizing or eliminating the presence of HO-2 to thus reduce or prevent binding of HO-2 to the group-specific antigen (Gag) of the viral proteins. The invention is particularly applicable to the production of lentiviruses from viral proteins wherein the Matrix domain (MA) of the Gag is myristoylated.

Claim (Index 14):
The method of  claim 2 , wherein the reduction or prevention of HO-2 binding is achieved by genetic knockdown comprising preparation of a suitable siRNA or construction of an shRNA expression plasmid, followed by the transfection of one of these constructs into cultured cells.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 97.0
- Lexical Diversity: 2.0303
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10478753', '14346961', '14069696', '12175809', '10545426']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6551967128837786
- 35 USC 102 Novelty (BERT): 0.5234451278862438
- Combined Prediction Score: 0.6420215543840251
- Mean Citation Score: 267.687762
- Max Citation Score: 295.00204
- Similarity Product: 191.42834538918007

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test