PATENT CLAIM ANALYSIS

Application Number: 15751495
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "184000"]

Abstract:
Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal coordinated by a macrocycle comprising the pentaaza 15-membered macrocyclic ring corresponding to Formula A and two axial ligands having the formula —OC(O)X 1 . each of the two axial ligands has the formula —OC(═O)X 1  wherein each X 1  is independently substituted or unsubstituted phenyl or —C(—X 2 )(—X 3 )(—X 4 ); each X 2  is independently substituted or unsubstituted phenyl, or substituted or unsubstituted alkyl; each X 3  is independently hydrogen, hydroxyl, alkyl, amino, —X 5 C(═O)R 13  where X 5  is NH or O, and R 13  is C 1 -C 18  alkyl, substituted or unsubstituted aryl or C 1 -C 18  aralkyl, or —OR 14 , where R 14  is C 1 -C 18  alkyl, substituted or unsubstituted aryl or C 1 -C 18  aralkyl, or together with X 4  is (═O); and each X 4  is independently hydrogen or together with X 3  is (═O).

Claim (Index 2):
A pentaaza macrocyclic ring complex of Formula (IA): wherein M is a transition metal (e.g., Mn 2+ , Mn 3+ , Mn 4+ , Mn 6+ , Mn 7+ , Fe 2+ , Fe 3+ , Fe 4+ , Fe 6+ , Ni 2+ , Ni 3+ , Cu 1+ , Cu 2+ , V 2+ , V 3+ , V 4+ , or V 5+ ); R 1A , R 1B , R 2 , R 3 , R 4A , R 4B , R 5 , R 6 , R 7A , R 7B , R 8 , R 9 , R 10A , and R 10B  are independently hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclyl, an amino acid side chain moiety, or a moiety independently selected from the group consisting of \u2014OR 11 , \u2014NR 11 R 12 , \u2014COR 11 , \u2014CO 2 R 11 , \u2014C(\u2550O)NR 11 R 12 , \u2014SR 11 , \u2014SOR 11 , \u2014SO 2 R 11 , \u2014SO 2 NR 11 R 12 , \u2014N(OR 11 )(R 12 ), \u2014P(\u2550O)(OR 11 )(OR 12 ), \u2014P(\u2550O)(OR 11 )(R 12 ), and \u2014OP(\u2550O)(OR 11 )(OR 12 ),\n wherein R 11  and R 12  are independently hydrogen or alkyl; \n U, together with the adjacent carbon atoms of the macrocycle, forms a fused substituted or unsubstituted, saturated, partially saturated or unsaturated, cycle or heterocycle having 3 to 20 ring carbon atoms; \n V, together with the adjacent carbon atoms of the macrocycle, forms a fused substituted or unsubstituted, saturated, partially saturated or unsaturated, cycle or heterocycle having 3 to 20 ring carbon atoms; \n W, together with the nitrogen of the macrocycle and the carbon atoms of the macrocycle to which it is attached, forms an aromatic or alicyclic, substituted or unsubstituted, saturated, partially saturated or unsaturated nitrogen-containing fused heterocycle having 2 to 20 ring carbon atoms, provided that when W is a fused aromatic heterocycle the hydrogen attached to the nitrogen which is both part of the heterocycle and the macrocycle and R 5  and R 6  attached to the carbon atoms which are both part of the heterocycle and the macrocycle are absent; wherein \n each X 1  is independently substituted or unsubstituted phenyl or \u2014C(\u2014X 2 )(\u2014X 3 )(\u2014X 4 ); \n each X 2  is independently substituted or unsubstituted phenyl, methyl, ethyl or propyl; \n each X 3  is independently hydrogen, hydroxyl, methyl, ethyl, propyl, amino, \u2014X 5 C(\u2550O)R 13  where X 5  is NH or O, and R 13  is C 1 -C 18  alkyl, substituted or unsubstituted aryl or C 1 -C 18  aralkyl, or \u2014OR 14 , where R 14  is C 1 -C 18  alkyl, substituted or unsubstituted aryl or C 1 -C 18  aralkyl, or together with X 4  is (\u2550O); \n each X 4  is independently hydrogen or together with X 3  is (\u2550O); and \n the bonds between the transition metal M and the macrocyclic nitrogen atoms and the bonds between the transition metal M and the oxygen atoms of the axial ligands \u2014OC(O)X 1  are coordinate covalent bonds.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 88.0
- Lexical Diversity: 2.7013
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15246830', '15246788', '15301084', '11871848', '14302082']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8140370666361513
- 35 USC 102 Novelty (BERT): 0.6112329055341709
- Combined Prediction Score: 0.7937566505259532
- Mean Citation Score: 462.228354
- Max Citation Score: 768.2074
- Similarity Product: 452.7769949981928

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test