PATENT CLAIM ANALYSIS

Application Number: 15886578
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "047000"]

Abstract:
A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base 1 , Base 2 , Y, Y a , X a , X a1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3 , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , and R 8a  are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Claim (Index 15):
A compound of formula (I\u2033): or a pharmaceutically acceptable salts thereof, wherein\n Base 1  and Base 2  are each independently selected from the group consisting of \n Y is selected from the group consisting of \u2014O\u2014 and \u2014S\u2014; X c  and X c1  are each independently selected from the group consisting of OR 9  and SR 9 ; X d  and X d1  are each independently selected from the group consisting of O and S; R 2a  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N 3 , C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, C 2 -C 6  haloalkenyl, C 2 -C 6  haloalkynyl, \u2014O\u2014C 1 -C 6  alkyl, \u2014O\u2014C 2 -C 6  alkenyl, and \u2014O\u2014C 2 -C 6  alkynyl; R 3  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N 3 , C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, C 2 -C 6  haloalkenyl, C 2 -C 6  haloalkynyl, \u2014O\u2014C 1 -C 6  alkyl, \u2014O\u2014C 2 -C 6  alkenyl, and \u2014O\u2014C 2 -C 6  alkynyl; R 4  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N 3 , C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, C 2 -C 6  haloalkenyl, C 2 -C 6  haloalkynyl, \u2014O\u2014C 1 -C 6  alkyl, \u2014O\u2014C 2 -C 6  alkenyl, and \u2014O\u2014C 2 -C 6  alkynyl; R 5  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, NH 2 , N 3 , C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, C 2 -C 6  haloalkenyl, C 2 -C 6  haloalkynyl, \u2014O\u2014C 1 -C 6  alkyl, \u2014O\u2014C 2 -C 6  alkenyl, and \u2014O\u2014C 2 -C 6  alkynyl; R 6a  is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N 3 , C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, C 2 -C 6  haloalkenyl, C 2 -C 6  haloalkynyl, \u2014O\u2014C 1 -C 6  alkyl, \u2014O\u2014C 2 -C 6  alkenyl, and \u2014O\u2014C 2 -C 6  alkynyl; each R 9  is independently selected from the group consisting of H, C 1 -C 20  alkyl, where each R 9  C 1 -C 20  alkyl is optionally substituted by 0 to 3 substituents independently selected from the group consisting of OH, \u2014O\u2014C 1 -C 20  alkyl, \u2014S\u2014C(O)C 1 -C 6  alkyl, and C(O)OC 1 -C 6  alkyl; and\n optionally R 3  and R 6a  are connected to form \u2014O\u2014C 1 -C 6  alkylene, \u2014O\u2014C 2 -C 6  alkenylene, or \u2014O\u2014C 2 -C 6  alkynylene, such that where R 3  and R 6a  are connected to form \u2014O\u2014C 1 -C 6  alkylene, \u2014O\u2014C 2 -C 6  alkenylene, or \u2014O\u2014C 2 -C 6  alkynylene, said O is bound at the R 3  position; and \n with the provisos that\n (a) when Y and Y a  are each O, X a  and X a1  are each O, X b  and X b1  are each O, and X c  and X c1  are each OH or SH, X d  and X d1  are each O, R 1  and R 1a  are each H, R 2  is H, R 6  and R 6a  are each H, R 7  and R 7a  are each H, R 8  and R 8a  are each H, and Base 1  and Base 2  are each selected from the group consisting of \n \n then R 5  and R 3  are not both selected from the group consisting of H, F and OH, and\n (b) the compound is not selected from the group consisting of \n and pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 88.0
- Lexical Diversity: 2.15152
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15234182', '15586634', '15368921', '15287805', '14068774']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8066204261114199
- 35 USC 102 Novelty (BERT): 0.5720930196347326
- Combined Prediction Score: 0.7831676854637513
- Mean Citation Score: 316.1777600000001
- Max Citation Score: 501.73862
- Similarity Product: 367.5137981832445

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test