PATENT CLAIM ANALYSIS

Application Number: 15861386
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "456000"]

Abstract:
Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), or metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.

Claim (Index 32):
A method of modulating estrogenic hormone action to ameliorate or enhance at least one condition of the skin or hair of a subject, comprising administering a composition comprising racemic equol, wherein the racemic equol binds estrogen receptor subtypes, and wherein ameliorating or enhancing at least one condition of the skin or hair of the subject comprises at least one of:\n a) enhancing antioxidant content of the skin; b) reducing skin inflammation; c) improving skin thickness; d) reducing skin adipose tissue (fat) and cellulite formation; e) enhancing skin blood flow; f) enhancing collagen and elastin; g) improving skin abrasions and the appearance of scars; h) enhancing wound healing; i) diminishing skin pigmentation or dermal age spots; j) enhancing skin lightening; k) diminishing facial hair (hirsutism) or body hair; and l) reducing skin oil production.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 86.0
- Lexical Diversity: 1.70886
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15065344', '13442466', '12572791', '13903748', '11506443']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8761749856831182
- 35 USC 102 Novelty (BERT): 0.6870221119055788
- Combined Prediction Score: 0.8572596983053643
- Mean Citation Score: 794.0860099999999
- Max Citation Score: 838.1628
- Similarity Product: 672.033198375678

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test