PATENT CLAIM ANALYSIS

Application Number: 15756908
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "006100"]

Abstract:
The invention relates to the use of certain micro-RNAs circulating in the blood serum or blood plasma in the form of diagnostic profiles as a marker in an in vitro method for distinguishing between patients for which a myocardial biopsy is necessary for the diagnostic identification of a heart muscle disease and patients for which myocardial biopsy is not necessary, and for the optional differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases affecting the heart.

Claim (Index 4):
The in-vitro or in-vivo method as claimed in  claim 1 , wherein:\n the diagnostic profile for identifying amyloidosis of the heart additionally comprises at least 3 microRNAs or synthetic nucleic acids having identical or complementary sequences, selected from the group consisting of the following microRNAs:\n hsa-miR-103a-3p (SEQ ID NO: 72), hsa-miR-106b-5p (SEQ ID NO: 73), hsa-miR-126-3p (SEQ ID NO: 74), hsa-miR-126-5p (SEQ ID NO: 75), hsa-miR-1274A (SEQ ID NO: 76), hsa-miR-1274B (SEQ ID NO: 77), hsa-miR-132-3p (SEQ ID NO: 78), hsa-miR-140-3p (SEQ ID NO: 79), hsa-miR-142-3p (SEQ ID NO: 80), hsa-miR-146b-5p (SEQ ID NO: 81), hsa-miR-150-5p (SEQ ID NO: 82), hsa-miR-15b-5p (SEQ ID NO: 83), hsa-miR-181b-5p (SEQ ID NO: 84), hsa-miR-186-5p (SEQ ID NO: 85), hsa-miR-21-5p (SEQ ID NO: 86), hsa-miR-222-3p (SEQ ID NO: 87), hsa-miR-223-5p (SEQ ID NO: 88), hsa-miR-24-3p (SEQ ID NO: 89), hsa-miR-26b-5p (SEQ ID NO: 90), hsa-miR-30a-3p (SEQ ID NO: 91), hsa-miR-30d-5p (SEQ ID NO: 92), hsa-miR-320a (SEQ ID NO: 93), hsa-miR-320c (SEQ ID NO: 94), hsa-miR-328-3p (SEQ ID NO: 95), hsa-miR-375 (SEQ ID NO: 96), hsa-miR-378-5p (SEQ ID NO: 97), hsa-mir-423 (SEQ ID NO: 98), hsa-miR-4286 (SEQ ID NO: 99), hsa-miR-451a (SEQ ID NO: 100), hsa-miR-4535 (SEQ ID NO: 101), hsa-miR-483-5p (SEQ ID NO: 102), hsa-miR-518d-3p (SEQ ID NO: 103), hsa-miR-532-5p (SEQ ID NO: 104), hsa-miR-590-5p (SEQ ID NO: 105), hsa-miR-601 (SEQ ID NO: 106), hsa-miR-660-5p (SEQ ID NO: 107), hsa-miR-885-5p (SEQ ID NO: 108), hsa-miR-92a-3p (SEQ ID NO: 109), hsa-miR-99b-5p (SEQ ID NO: 110).

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.56
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13899555', '14788843', '15320208', '13642321', '15237364']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6975407214024861
- 35 USC 102 Novelty (BERT): 0.5221351630252244
- Combined Prediction Score: 0.68000016556476
- Mean Citation Score: 338.831186
- Max Citation Score: 342.94568
- Similarity Product: 230.10132392743583

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test