PATENT CLAIM ANALYSIS

Application Number: 15979128
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "236200"]

Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).

Claim (Index 1):
A compound represented by Formula (I) or a pharmaceutically acceptable salt, or ester thereof: wherein; is selected from X 1 , X 2  and X 3  are each independently selected from N or C(R 5 ); R 3 , R 4  and R 5  are each independently selected from the group consisting of: 1) Hydrogen; 2) Halogen; 3) \u2014NO 2 ; 4) Cyano; 5) Optionally substituted \u2014C 1 \u2014C 8  alkyl; 6) Optionally substituted \u2014C 3 \u2014C 8  cycloalkyl; 7) Optionally substituted 3- to 8-membered heterocycloalkyl; and 8) Optionally substituted \u2014C 1 \u2014C 8  alkoxyl; R is selected from: each of which is optionally substituted when possible;\n R 1  is selected from the group consisting of: \n 1) Hydrogen; \n 2) Optionally substituted \u2014C 1 \u2014C 8  alkyl; \n 3) Optionally substituted \u2014C 2 \u2014C 8  alkenyl; \n 4) Optionally substituted \u2014C 2 \u2014C 8  alkynyl; \n 5) Optionally substituted \u2014C 3 \u2014C 8  cycloalkyl; \n 6) Optionally substituted aryl; \n 7) Optionally substituted arylalkyl; \n 8) Optionally substituted 3- to 8-membered heterocycloalkyl; \n 9) Optionally substituted heteroaryl; \n 10) Optionally substituted heteroarylalkyl; and \n 11) \u2014N(R 6 )(R 7 ); \n provided that when R is \n R 1  is not \u2014N(R 6 )(R 7 );\n R 2  is selected from the group consisting of: \n 1) Hydrogen; \n 2) Halogen; \n 3) \u2014NO 2 ; \n 4) Cyano; \n 5) Optionally substituted \u2014C 1 \u2014C 8  alkyl; \n 6) Optionally substituted \u2014C 2 \u2014C 8  alkenyl; \n 7) Optionally substituted \u2014C 2 \u2014C 8  alkynyl; \n 8) Optionally substituted \u2014C 3 \u2014C 8  cycloalkyl; \n 9) Optionally substituted aryl; \n 10) Optionally substituted arylalkyl; \n 11) Optionally substituted 3- to 8-membered heterocycloalkyl; \n 12) Optionally substituted heteroaryl; \n 13) Optionally substituted heteroarylalkyl; \n 14) \u2014N(R 6 )(R 7 ); \n 15) \u2014S(O) 2 N(R 6 )(R 7 ); \n 16) \u2014N(R 6 )C(O)(R 7 ); and \n 17) \u2014N(R 6 )S(O) 2 (R 7 ); \n wherein R 6  and R 7  are independently selected from the group consisting of hydrogen, \u2014C 1 \u2014C 15  alkyl, preferably C 1 \u2014C 8 -alkyl; cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, wherein each alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl is optionally substituted with 1-3 substituents independently selected from halo, alkyl, alkylamino, dialkylamino, alkylC(O)NH\u2014, arylC(O)NH\u2014, heteroarylC(O)\u2014NH, \u2014CN, alkoxy, \u2014CF 3 , aryl, and heteroaryl, alternatively, R 7  and R 8  are taken together with the nitrogen to which they are attached to form a heterocyclic.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 93.0
- Lexical Diversity: 1.84416
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12974622', '15724919', '16063542', '14670421', '15597417']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8093089653451202
- 35 USC 102 Novelty (BERT): 0.5136665454647319
- Combined Prediction Score: 0.7797447233570813
- Mean Citation Score: 304.51726799999994
- Max Citation Score: 310.5816700000001
- Similarity Product: 252.05578197116145

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test