PATENT CLAIM ANALYSIS

Application Number: 16135593
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-02
Patent Classification: ["548", "240000"]

Abstract:
This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

Claim (Index 21):
A compound of formula (CC 1) or a stereoisomer, enantiomer or tautomer thereof, wherein,\n each dotted line individually represents an optional double bond, wherein maximally two dotted lines selected from the five dotted lines are a double bond; \n each of G 1 , G 2 , G 3  and G 4  is independently selected from N; NR c3 ; O; CHR c3 ; and CR c3 ; wherein two of G 1 , G 2 , G 3  and G 4  are selected from N; NR c3 ; and O; while the other two of G 1 , G 2 , G 3  and G 4  are selected from CHR c3 ; and CR c3 ; \n each R 3  is selected from hydrogen; and alkyl; \n R 5  is independently selected from halogen; \u2014OH; \u2014OR 10 ; \u2014SH; \u2014SR 10 ; \u2014S(O)R 11 ; \u2014S(O) 2 R 11 ; \u2014SO 2 NR 12 R 13 ; trifluoromethyl; trifluoromethoxy; nitro; \u2014NHC(O)R 10 ; \u2014NHS(O) 2 R 10 ; \u2014NHC(O)NR 12 R 13 ; \u2014NR 10 C(O)R 10 ; \u2014NR 10 S(O) 2 R 10 ; \u2014NR 10 C(O)NR 12 R 13 ; \u2014NR 12 R 13 ; -cyano; \u2014COOH; \u2014COOR 10 ; \u2014C(O)NR 12 R 13 ; \u2014C(O)R 11 ; alkyl; alkenyl; alkynyl; aryl; heterocycle; arylalkylene; arylalkenylene; arylalkynylene; heterocycle-alkylene; heterocycle-alkenylene; heterocycle-alkynylene;\n and wherein said alkyl, alkenyl, alkynyl, aryl, heterocycle, arylalkylene, arylalkenylene, arylalkynylene, heterocycle-alkylene, heterocycle-alkenylene or heterocycle-alkynylene, optionally includes one or more heteroatoms in the alkyl(ene), alkenyl(ene) or alkynyl(ene) moiety, said heteroatoms being selected from the atoms O, S and N; \n and wherein a carbon atom or heteroatom of said alkyl, alkenyl, alkynyl, aryl, heterocycle, arylalkylene, arylalkenylene, arylalkynylene, heterocycle-alkylene, heterocycle-alkenylene or heterocycle-alkynylene, can be oxidized to form a C\u2550O, C\u2550S, N\u2550O, N\u2550S, S\u2550O or S(O) 2 ; \n \n q is selected from 0; 1; 2; or 3; preferably q is 0 or 1; \n E is selected from hydrogen; halogen; \u2014OH; \u2014OR 10 ; \u2014SH; \u2014SR 10 ; trifluoromethoxy; \u2014NHC(O)R 10 ; \u2014NHS(O) 2 R 10 ; \u2014NHC(O)NR 12 R 13 ; \u2014NR 10 C(O)R 10 ; \u2014NR 10 S(O) 2 R 10 ; \u2014NR 10 C(O)NR 12 R 13 ; \u2014NR 12 R 13 ; \n each R 10  is independently selected from alkyl; alkenyl; alkynyl; aryl; heterocycle; arylalkylene; arylalkenylene; arylalkynylene; heterocycle-alkylene; heterocycle-alkenylene or heterocycle-alkynylene; \n and wherein said alkyl, alkenyl, alkynyl, aryl, heterocycle, arylalkylene, arylalkenylene, arylalkynylene, heterocycle-alkylene, heterocycle-alkenylene or heterocycle-alkynylene optionally include one or more heteroatoms in the alkyl(ene), alkenyl(ene) or alkynyl(ene) moiety, said heteroatom selected from O, S and N; \n and wherein a carbon atom or heteroatom of said alkyl, alkenyl, alkynyl, aryl, heterocycle, arylalkylene, arylalkenylene, arylalkynylene, heterocycle-alkylene, heterocycle-alkenylene or heterocycle-alkynylene, can be oxidized to form a C\u2550O, C\u2550S, N\u2550O, N\u2550S, S\u2550O or S(O) 2 ; \n each R 12  and R 13  is independently selected from hydrogen; alkyl; alkenyl; alkynyl; aryl; heterocycle; arylalkylene; arylalkenylene; arylalkynylene; heterocycle-alkylene; heterocycle-alkenylene or heterocycle-alkynylene; \n and wherein said alkyl, alkenyl, alkynyl, aryl, heterocycle, arylalkylene, arylalkenylene, arylalkynylene, heterocycle-alkylene, heterocycle-alkenylene or heterocycle-alkynylene optionally include one or more heteroatoms in the alkyl(ene), alkenyl(ene) or alkynyl(ene) moiety, said heteroatom selected from O, S and N; \n and wherein a carbon atom or heteroatom of said alkyl, alkenyl, alkynyl, aryl, heterocycle, arylalkylene, arylalkenylene, arylalkynylene, heterocycle-alkylene, heterocycle-alkenylene or heterocycle-alkynylene, can be oxidized to form a C\u2550O, C\u2550S, N\u2550O, N\u2550S, S\u2550O or S(O) 2 ; \n and wherein R 12  and R 13  can be taken together in order to form a (5-, 6-, or 7-membered) heterocycle which can be unsubstituted or substituted; \n each of R 1c  and R 2c  is independently selected from hydrogen; halogen; alkyl; alkenyl or alkynyl; \n and stereoisomers, enantiomers or tautomers, solvates, hydrates, or salts (in particular pharmaceutically acceptable salts) thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 97.0
- Lexical Diversity: 1.88235
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14060563', '15215750', '13993723', '13993756', '13377505']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8851946315059731
- 35 USC 102 Novelty (BERT): 0.6078394361142868
- Combined Prediction Score: 0.8574591119668045
- Mean Citation Score: 683.32623
- Max Citation Score: 725.93085
- Similarity Product: 464.6099690672725

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test