PATENT CLAIM ANALYSIS

Application Number: 15993059
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "475000"]

Abstract:
The present invention relates to modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of preventing, inducing, causing or increasing weight loss, treating obesity and/or treating metabolic syndrome utilizing the modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of improving insulin sensitivity and glycemic control, reducing insulin levels and/or improving leptin sensitivity utilizing the modified or polymer conjugated MetAP2 inhibitors.

Claim (Index 2):
A method for lowering or decreasing blood glucose levels in a subject in need thereof comprising administering at least one compound, or a pharmaceutically acceptable salt, prodrug, metabolite, analog or derivative thereof, of the Formula wherein, independently for each occurrence,\n R 4  is H or C 1 -C 6  alkyl; \n R 5  is H or C 1 -C 6  alkyl; \n R 6  is C 2 -C 6  hydroxyalkyl; \n Z is \u2014NH-AA 1 -AA 2 -AA 3 -AA 4 -AA 5 -AA 6 -C(O)-L or \u2014NH-AA 1 -AA 2 -AA 3 -AA 4 -AA 5 -AA 6 -C(O)-Q-X\u2014Y\u2014C(O)\u2014W; \n AA 1  is glycine, alanine, or H 2 N(CH 2 ) m CO 2 H, wherein m is 2, 3, 4 or 5; \n AA 2  is a bond, or alanine, cysteine, aspartic acid, glutamic acid, phenylalanine, glycine, histidine, isoleucine, lysine, leucine, methionine, asparagine, proline, glutamine, arginine, serine, threonine, valine, tryptophan, or tyrosine; \n AA 3  is a bond, or alanine, cysteine, aspartic acid, glutamic acid, phenylalanine, glycine, histidine, isoleucine, lysine, leucine, methionine, asparagine, proline, glutamine, arginine, serine, threonine, valine, tryptophan, or tyrosine; \n AA 4  is a bond, or alanine, cysteine, aspartic acid, glutamic acid, phenylalanine, glycine, histidine, isoleucine, lysine, leucine, methionine, asparagine, proline, glutamine, arginine, serine, threonine, valine, tryptophan, or tyrosine; \n AA 5  is a bond, or glycine, valine, tyrosine, tryptophan, phenylalanine, methionine, leucine, isoleucine, or asparagine; \n AA 6  is a bond, or alanine, asparagine, citrulline, glutamine, glycine, leucine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine, or H 2 N(CH 2 ) m CO 2 H, wherein m is 2, 3, 4 or 5; \n L is \u2014OH, \u2014O-succinimide, \u2014O-sulfosuccinimide, alkoxy, aryloxy, acyloxy, aroyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, \u2014NH 2 , \u2014NH(C 2 -C 6  hydroxyalkyl), halide or perfluoroalkyloxy; \n Q is NR, O, or S; \n X is M-(C(R) 2 ) p -M-J-M-(C(R) 2 ) p -M-V; \n M is a bond, or C(O); \n J is a bond, or ((CH 2 ) q Q) r , C 5 -C 8  cycloalkyl, aryl, heteroaryl, NR, O, or S; \n Y is NR, O, or S; \n R is H or alkyl; \n V is a bond or \n R 9  is alkyl, aryl, aralkyl, or a bond; or R 9  taken together with Y forms a heterocyclic ring; R 10  is amido or a bond; R 11  is H or alkyl; W is a methionine aminopeptidase-2 inhibitor moiety or alkyl; x is in the range of 1 to about 450; y is in the range of 1 to about 30; n is in the range of 1 to about 50; p is 0 to 20; q is 2 or 3; and r is 1, 2, 3, 4, 5, or 6; in a therapeutically effective amount to the subject.

Metadata:
- Claim Count in Document: 143.0
- Percentile: 93.0
- Lexical Diversity: 2.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15665755', '15226258', '14851668', '14248787', '15226267']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8502157764761171
- 35 USC 102 Novelty (BERT): 0.6178664268705482
- Combined Prediction Score: 0.8269808415155603
- Mean Citation Score: 579.961532
- Max Citation Score: 581.8517
- Similarity Product: 520.0713383204342

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test