PATENT CLAIM ANALYSIS

Application Number: 16353693
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "064000"]

Abstract:
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.

Claim (Index 1):
A compound of the formula (III-2) or (IV-2)\u2032: or a pharmaceutically acceptable salt thereof, wherein: J, L, and M are each independently CR 5 ; R 1 , R 2 , R 3  and R 4  is independently selected from \u2014H, halogen, C 1-4 alkyl, O\u2014C 1-4 alkyl, C 3-7  carbocyclyl, 4-10 membered heterocyclyl, C 6-10 aryl, and 5-10 membered heteroaryl; each R 5  is independently selected from the group consisting of H, OH, halogen, \u2014C(O)OR 1 ; \u2014C(O)NR 1 R 2 ; \u2014C(O)NR 1 OR 2 ; \u2014C(\u2550NR 1 )R 2 ; \u2014C(\u2550NR 1 )NR 2 R 3 ; \u2014NR 1 C(O)R 2 ; \u2014NR 1 C(O)NR 2 R 3 ; \u2014NR 1 C(O)OR 2 ; \u2014NR 1 S(O) 2 R 2 ; \u2014NR 1 S(O) 2 NR 2 R 3 ; \u2014NR 1 CR 2 (\u2550NR 3 ); \u2014NR 1 C(\u2550NR 2 )NR 3 R 4 ; \u2014S(O)(CH 2 ) 1-3 R 4 , \u2014S(O) 2 NR 1 R 2 , \u2014S(O) 2 NR 1 OR 3 , \u2014NR 1 S(O) 2NR 1 OR 3 , C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 2 -C 6  alkynyl C 1 -C 6  heteroalkyl, C 3 -C 7  carbocyclyl, 5-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, cyano, C 1 -C 6  alkoxy(C 1 -C 6 )alkyl, aryloxy, sulfhydryl, and \u2014(CH 2 ) p \u2014Y 3 \u2014(CH 2 ) q M\u2032; p and q are each independently 0, 1, or 2; Y 3  is selected from the group consisting of \u2014S\u2014, \u2014S(O)\u2014, \u2014S(O) 2 \u2014, \u2014O\u2014, \u2014CR 1 R 2 \u2014, and \u2014NR 1 \u2014; M\u2032 is selected from the group consisting of halogen, cyano, \u2014OH, \u2014C(O)NR 1 R 2 ; \u2014C(O)NR 1 OR 2 ; \u2014NR 1 C(O)R 2 ; \u2014NR 1 C(O)NR 2 R 3 ; \u2014NR 1 C(O)OR 2 ; \u2014NR 1 S(O) 2 R 2 ; \u2014NR 1 S(O) 2 NR 2 R 3 ; \u2014C(\u2550NR 1 )R 2 ; \u2014C(\u2550NR 1 )NR 2 R 3 ; \u2014NR 1 CR 2 (\u2550NR 3 ); \u2014NR 1 C(\u2550NR 2 )NR 3 R 4 ; \u2014S(O) 2 R 1 , \u2014S(O) 2 NR 1 R 2 , \u2014S(O) 2 NR 1 OR 3 , C 1-4  alkyl substituted with 0-2 substituents selected from the group consisting of \u2014OR 1 , \u2014CN, \u2014NR 1 R 2 , -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; C 2-4  alkenyl substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; C 2-4  alkynyl substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; C 6-10  aryl substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; C 3-7  carbocyclyl substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; 5-10 membered heteroaryl substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; and 3-10 membered heterocyclyl substituted with 0-2 substituents selected from the group consisting of C 1-4  alkyl, \u2014(CH 2 ) 0-4 OR 1 , \u2014(CH 2 ) 0-4 CN, \u2014(CH 2 ) 0-4 NR 1 R 2 , \u2014(CH 2 ) 0-4 -heterocyclyl, halogen, \u2014C(O)NR 1 R 2 , and \u2014NR 1 C(O)R 2 ; R 6  is selected from the group consisting of H, halogen, substituted \u2014C 1-6  alkyl, \u2014OH, \u2014C(O)OR, \u2014P(O)(OR) 2 , \u2014P(O)(OR)R 1 , \u2014O\u2014C 1-6  alkyl, \u2014NR 1 R 2 , \u2014N(OR 1 )R 2 , \u2014S\u2014C 1-6  alkyl, \u2014C(O)NR 1 R 2 , \u2014S(O) 2 NR 1 R 2 , CN, \u2014S(O)\u2014C 1-6  alkyl, and \u2014S(O) 2 \u2014C 1-6  alkyl; R is selected from \u2014H, alkali metal, NH 4 + , \u2014C 1-9 alkyl, \u2014CR 10 R 11 OC(O)C 1-9 alkyl, \u2014CR 10 R 11 OC(O)OC 1-9alkyl, \u2014CR 10 R 11 OC(O)C 6-10 aryl, \u2014CR 10 R 11 OC(O)OC 6-10 aryl, \u2014CR 10 R 11 OC(O)NR 10 C 1-9 alkyl, \u2014CR 10 R 11 OC(O) NR 10 C 6-10 aryl, and and\n R 10  and R 11  are independently selected from the group consisting of \u2014H, C 1-4 alkyl, C 3-7  carbocyclyl, 5-10 membered heterocyclyl, C 6-10 aryl, and 5-10 membered heteroaryl.

Metadata:
- Claim Count in Document: 74.0
- Percentile: 99.0
- Lexical Diversity: 1.2
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15636424', '15323081', '14146671', '14146643', '15312173']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7936912767735723
- 35 USC 102 Novelty (BERT): 0.557778337505751
- Combined Prediction Score: 0.7700999828467902
- Mean Citation Score: 400.040456
- Max Citation Score: 424.56717
- Similarity Product: 338.9913266152435

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test