PATENT CLAIM ANALYSIS

Application Number: 16191369
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["524", "555000"]

Abstract:
Micro-nano materials, products obtained by covalently modifying the surfaces of micro/nano materials with hydrophilic materials, and methods for making the same. The micro/nano materials on the surfaces have carboxyl groups or/and pro-carboxyl groups which are converted into their active esters. The products are covalently modified by forming amide bonds between the active esters on the surfaces and the modification agents; where the modification agents are hydrophilic compounds and/or hydrophilic polymers bearing primary and/or secondary aliphatic amines. Monomers bearing carboxyl groups and/or pro-carboxyl groups are used to produce an adequate number of carboxyl groups and/or pro-carboxyl groups on the surface of a polymer material to be modified. The carboxyl groups and/or pro-carboxyl groups are converted into active esters. A reasonably-sized modification agent bearing primary and/or secondary amines, zwitterions and hydrophilic linear spacer arms is used to form amide bonds and obtain a covalently modified surface layer.

Claim (Index 1):
A method for preparing a product obtained by covalently modifying the surface of a micro/nano material with a hydrophilic material, wherein the micro/nano material to be modified on the surface comprises a functional group selected from one or more of a carboxyl group, a pro-carboxyl group, an active ester, a cation, an anion, a neutral hydrophilic group, a metal ion chelating group or a protein-disulfide-selective modification group; wherein the functional group on the surface of the micro/nano material to be modified is derived from organic monomers used in making the micro/nano material through polymerization reaction, or produced through derivatization of the carboxyl group and/or the pro-carboxyl group of the organic monomers used in the polymerization reaction;\n wherein the covalently-modified product comprises a product of mono-layer covalent modification and a product bearing multilayer covalent modification; the carboxyl group and the pro-carboxyl group on the surface of the micro/nano material to be modified are converted into active esters to form amide bonds with a hydrophilic compound and/or a hydrophilic polymer containing a primary aliphatic amine or/and a secondary aliphatic amine as a modification agent for covalent modification to obtain the product of mono-layer covalent modification; and the active esters are formed repeatedly on the surface of the covalently-modified product, and a hydrophilic compound and/or a hydrophilic polymer containing primary aliphatic amine or/and secondary aliphatic amine is used as the modification agent to repeatedly form the amide bonds for covalent modification to obtain the product bearing multilayer covalent modification; the method comprises the following steps: a. when a micro/nano material having a carboxyl group or/and a pro-carboxyl group on the surface is used as a micro/nano material to be modified, forming an active ester of the carboxyl group or/and the pro-carboxyl group on the surface of the micro/nano material; wherein in step a, the active ester on the micro/nano material to be modified is derived from the carboxyl group or/and the pro-carboxyl group on the surface of the micro/nano material, through one of the following ways: directly converting the carboxyl group on the surface of the micro/nano material into the active ester, or converting the pro-carboxyl group on the surface of the micro/nano material into the carboxyl group which is then converted into the active ester, or converting the pro-carboxyl group on the surface of the micro/nano material into an aliphatic hydroxyl group and/or an aliphatic amine group which is then converted into the active ester using CDI or TPG, or directly converting the pro-carboxyl group on the surface of the micro/nano material into the active ester; reacting the active ester with a long linear amino acid to obtain a carboxyl group, reacting the active ester with a long linear polyamine to re-obtain a aliphatic amine group or further with cyclic acid anhydride to re-obtain a carboxyl group, so as to insert a linking arm between the carboxyl group or the pro-carboxyl group and the micro/nano material, and then converting a surface carboxyl group and/or a surface pro-carboxyl group obtained by derivation into the active ester; and b. forming an amide bond by covalently modifying the micro/nano material on the surface having active esters obtained in step a with a hydrophilic compound and/or a hydrophilic polymer containing a primary aliphatic amine or/and a secondary aliphatic amine as a modification agent; wherein in step b, the modification agent comprises an A type modification agent and a B type modification agent; and the molecular weight of the A type modification agent and the B type modification agent is 3000 Daltons or less; wherein the A type modification agent is a hydrophilic compound or a hydrophilic polymer containing a primary aliphatic amine or/and a secondary aliphatic amine; the hydrophilic compound or the hydrophilic polymer comprises one or more of N, N-dimethyl substituted aliphatic tertiary amine, N, N-diethyl substituted aliphatic tertiary amine and N, N-di-n-propyl substituted aliphatic tertiary amine; the A type modification agent is classified into an A1 subtype modification agent and an A2 subtype modification agent; the A1 subtype modification agent contains at least two primary aliphatic amines and/or secondary aliphatic amines and at least one N,N-dialkyl substituted aliphatic tertiary amine functional group per molecule; and the A2 subtype modification agent contains only one primary or secondary aliphatic amine, but contains at least one N,N-dialkyl substituted aliphatic tertiary amine functional group; in step b, the A1 subtype modification agent is used alone; or a mixture of the A1 subtype modification agent and the A2 subtype modification agent in any ratio is used; the sum of the molar amount of the primary aliphatic amine and the secondary aliphatic amine from the modification agent is in more than 10% excess to the molar amount of the active ester on the surface of the micro/nano material during modification; unless the last layer of covalent modification is to be realized, the A2 subtype modification agent is not used alone in step b; wherein the B type modification agent is a hydrophilic compound or polymer containing a primary aliphatic amine or/and a secondary aliphatic amine, without any one of N, N-dimethyl substituted aliphatic tertiary amine, N, N-diethyl substituted aliphatic tertiary amine and N, N-di-n-propyl substituted aliphatic tertiary amine, and is classified into a B1 subtype modification agent, a B2 subtype modification agent, a B3 subtype modification agent and a B4 subtype modification agent; wherein the B1 subtype modification agent has a linear structure, with a primary aliphatic amine or a secondary aliphatic amine at one end, and a carboxyl group or a pro-carboxyl group at the other end; the B2 subtype modification agent has a linear structure, with primary aliphatic amines and/or secondary aliphatic amines at both ends; the B3 subtype modification agent has a linear structure, with a primary aliphatic amine or a secondary aliphatic amine at one end, and a methoxy or ethoxy group at the other end; the B4 subtype modification agent has a non-linear structure containing at least two primary aliphatic amines and/or secondary aliphatic amines; in step b, one of the B1 subtype modification agent, the B2 subtype modification agent and the B4 subtype modification agent, or a mixture thereof in any ratio, is used, and the sum of molar amount of the primary aliphatic amine and the secondary aliphatic amine from the modification agent is in more than 10% excess to the molar amount of the active ester on the surface of the micro/nano material; the B3 subtype modification agent regulates the ratio of the molar amount of the primary aliphatic amine and the secondary aliphatic amine from the B1 subtype modification agent, the B2 subtype modification agent or the B4 subtype modification agent; unless the last layer of covalent modification is to be realized, the B3 subtype modification agent is not used alone in step b; wherein the A type modification agent and the B type modification agent are mixed in any ratio; the sum of the molar amount of the primary aliphatic amine and the secondary aliphatic amine from the modification agents is in more than 10% excess to the molar amount of the active ester on the surface of the micro/nano material; unless the last layer of covalent modification is to be realized, a mixture consisting of the A2 subtype modification agent and the B3 subtype modification agent in any ratio is not used in step b.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 98.0
- Lexical Diversity: 2.09459
- Patent Class: 524.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13751295', '14639035', '14114813', '15398288', '15398254']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8394114546419017
- 35 USC 102 Novelty (BERT): 0.4649067765359319
- Combined Prediction Score: 0.8019609868313047
- Mean Citation Score: 181.042228
- Max Citation Score: 186.06807
- Similarity Product: 142.16301442323626

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test