PATENT CLAIM ANALYSIS

Application Number: 16178517
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["548", "215000"]

Abstract:
The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R 1  is an aryl group which may have one or more substituents; R 2  is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by —Y 1 -A 1 - or —Y 2 —C(═O)— wherein Y 1  is a group such as —C(═O)—, A 1  is a group such as a lower alkylene group, and Y 2  is a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

Claim (Index 18):
A method for treating or preventing phosphodiesterase 4-mediated and/or tumor necrosis factor-\u03b1-mediated disease, the method comprising administering to human or animal in need thereof an oxazole compound represented by Formula (1) wherein R 1  is an aryl group which may have one or more substituents selected from the following (1-1) to (1-11): (1-1) hydroxy groups, (1-2) unsubstituted or halogen-substituted lower alkoxy groups, (1-3) lower alkenyloxy groups, (1-4) lower alkynyloxy groups, (1-5) cyclo C 3-8  alkyl lower alkoxy groups, (1-6) cyclo C 3-8  alkyloxy groups, (1-7) cyclo C 3-8  alkenyloxy groups, (1-8) dihydroindenyloxy groups, (1-9) hydroxy lower alkoxy groups, (1-10) oxiranyl lower alkoxy groups, and (1-11) protected hydroxy groups; R 2  is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents selected from the following (2-1) to (2-10): (2-1) hydroxy groups, (2-2) unsubstituted or halogen-substituted lower alkoxy groups, (2-3) unsubstituted or halogen-substituted lower alkyl groups, (2-4) lower alkenyloxy groups, (2-5) halogen atoms, (2-6) lower alkanoyl groups, (2-7) lower alkylthio groups, (2-8) lower alkylsulfonyl groups, (2-9) oxo groups, and (2-10) lower alkoxy lower alkoxy groups; and W is a divalent group represented by Formula (i) or (ii):\n \u2014Y 1 -A 1 -\u2003\u2003Formula (i) \n \u2014Y 2 \u2014C(\u2550O)\u2014\u2003\u2003Formula (ii) \n wherein A 1  is a lower alkenylene group, or a lower alkylene group which may have one or more substituents selected from the group consisting of hydroxy groups and lower alkoxycarbonyl groups, Y 1  is a direct bond, \u2014C(\u2550O)\u2014, \u2014C(\u2550O)\u2014N(R 3 )\u2014, \u2014N(R 4 )\u2014C(\u2550O)\u2014, S(O) m \u2014NH\u2014, or \u2014S(O) n \u2014 wherein R 3  and R 4  are each independently a hydrogen atom or a lower alkyl group, and m and n are each independently an integer from 0 to 2, and Y 2  is a piperazinediyl group, or a divalent group represented by Formula (iii) or (iv):\n \u2014C(\u2550O)-A 2 -N(R 5 )\u2014\u2003\u2003Formula (iii) \n -A 3 -N(R 6 )\u2014\u2003\u2003Formula (iv) \n wherein A 2  and A 3  are each independently a lower alkylene group, and R 5  and R 6  are each independently a hydrogen atom or a lower alkyl group; or a salt thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 98.0
- Lexical Diversity: 2.08197
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12090951', '13590227', '12599003', '14687051', '14147115']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7694676624383007
- 35 USC 102 Novelty (BERT): 0.5581472925960724
- Combined Prediction Score: 0.748335625454078
- Mean Citation Score: 372.00858200000016
- Max Citation Score: 479.36176
- Similarity Product: 325.3626699190235

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test