PATENT CLAIM ANALYSIS

Application Number: 16109288
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-05
Patent Classification: ["435", "006120"]

Abstract:
This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

Claim (Index 1):
A method of detecting at least one genetic variation in a polynucleotide analyte in a sample, comprising:\n a) combining the sample comprising the polynucleotide analyte with a first primer and a second primer, wherein a fluorophore is attached to the first primer, a quencher is attached to the second primer, the first primer and the second primer are specific for the first polynucleotide analyte and the fluorophore is different from the quencher; b) measuring a first signal generated by the fluorophore and quencher; c) performing at least one polymerization reaction with the first primer and the second primer using the polynucleotide analyte as a template; d) measuring a second signal generated by the fluorophore and quencher; e) comparing the first and second signals to determine a change between the first and second signals; and f) determining the presence or absence of the at least one genetic variation based i) on the change in signal as determined in step e); and ii) by further comparing said change to the change in signal observed for an analyte without the at least one genetic variation.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 96.0
- Lexical Diversity: 1.71739
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15675048', '14633094', '14210199', '11988946', '14566596']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5960976441408145
- 35 USC 102 Novelty (BERT): 0.6530077405122752
- Combined Prediction Score: 0.6017886537779605
- Mean Citation Score: 357.072692
- Max Citation Score: 656.3939999999999
- Similarity Product: 608.5859157596825

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test