PATENT CLAIM ANALYSIS

Application Number: 15744039
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["424", "204100"]

Abstract:
The invention relates to the improvement of endonuclease-based antimicrobials by blocking DNA repair of double-strand break(s) (DSB(s)) in prokaryotic cells. In this respect, the invention especially concerns a method involving blocking DNA repair after a nucleic acid has been submitted to DSB, in particular by a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated programmable double-strand endonuclease. The invention particularly relates to the use of an exogenous molecule that inhibits DNA repair, preferably a protein that binds to the ends of the double-stranded break to block DSB repair. The invention also relates to vectors, particularly phagemids and plasmids, comprising nucleic acids encoding nucleases and Gam proteins, and a pharmaceutical composition and a product containing these vectors and their application.

Claim (Index 36):
The method of  claim 28 , wherein the bacterium is selected from the group consisting of  Enterobacter, Streptococci, Staphylococci, Enterococci, Salmonella, Pseudomonas , and  Mycobacterium.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 86.0
- Lexical Diversity: 1.7375
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13842859', '15503383', '14685504', '14577997', '15261727']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.500593118751861
- 35 USC 102 Novelty (BERT): 0.5253430096981564
- Combined Prediction Score: 0.5030681078464905
- Mean Citation Score: 327.660292
- Max Citation Score: 331.9505
- Similarity Product: 251.183849896878

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test