PATENT CLAIM ANALYSIS

Application Number: 15962782
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["435", "052000"]

Abstract:
The subject of the present invention is a process for preparing a genetically modified yeast by multicopy integration of at least four expression cassettes, allowing the production of a molecule of interest at high titre. The subject of the present invention is also yeasts transformed according to said process, and the use thereof for producing hydrocortisone.

Claim (Index 46):
A yeast isolate comprising:\n 5-20 copies of two integration plasmids stably integrated into the chromosomes of the yeast isolate, wherein each integration plasmid comprising at least two expression cassettes, such that the two integration plasmids together comprise at least four expression cassettes, wherein the four expression cassettes of the two integration plasmids are P450scc, adrenodoxin (ADX), P450c11, and 3\u03b2-hydroxysteroid dehydrogenase (3\u03b2-HSD); and wherein the yeast isolate produces at least 100 mg/L hydrocortisone.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 91.0
- Lexical Diversity: 1.46341
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14127396', '10470673', '12683642', '12744959', '14178203']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6385994091875854
- 35 USC 102 Novelty (BERT): 0.6684226511304668
- Combined Prediction Score: 0.6415817333818735
- Mean Citation Score: 428.520356
- Max Citation Score: 711.5908
- Similarity Product: 636.0918905972958

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test