PATENT CLAIM ANALYSIS

Application Number: 15945428
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "337000"]

Abstract:
The present invention relates to the use of enfumafungin derivative triterpenoid antifungal compounds in combination with other antifungal agents such azoles, polyenes, lipopeptides, and allylamides to treat fungal diseases. More particularly, the invention relates to antifungal combinations of enfumafungin derivative triterpenoids which are inhibitors of (1,3)-β-D-glucan synthesis, in combination with other antifungal agents such as mold-active agents that have activity against molds, including but not limited to voriconazole, isavuconazole, posaconazole, itraconazole and amphotericin B, for the treatment and/or prevention of infections caused by molds.

Claim (Index 15):
A method of treating invasive pulmonary aspergillosis in a subject in need thereof, the method comprising administering to the subject a pharmaceutical combination of:\n (a) a first therapeutic agent that is a compound of Formula (II): which is (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid,\n or a pharmaceutically acceptable salt thereof; and \n (b) a second therapeutic agent that is voriconazole, isavuconazole, posaconazole, itraconazole, or amphotericin B.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 91.0
- Lexical Diversity: 1.52308
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12461318', '13058227', '12680472', '11727927', '15528457']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7542274424701407
- 35 USC 102 Novelty (BERT): 0.5902027177139296
- Combined Prediction Score: 0.7378249699945196
- Mean Citation Score: 446.761362
- Max Citation Score: 581.1538
- Similarity Product: 386.582500333488

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test