PATENT CLAIM ANALYSIS

Application Number: 15953622
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["424", "133100"]

Abstract:
The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions. The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.

Claim (Index 15):
A method for the production of soluble, antigen-specific heavy chain only antibodies comprising:\n (a) immunising a transgenic rodent expressing a heterologous V H  heavy chain locus with an antigen wherein:\n (i) the V H  heavy chain locus comprises a variable region comprising at least one V H  gene segment, at least five D gene segments, at least one J gene segment and at least one heavy chain constant region; \n (ii) said at least one heavy chain constant region does not encode a functional C H 1 domain; \n (iii) a V H  gene segment, a D gene segment and a J gene segment are capable of recombining to form a VDJ coding sequence; \n (iv) the recombined V H  heavy chain locus, when expressed upon antigen challenge, is capable of forming a soluble, heavy chain-only antibody comprising a soluble, antigen-specific V H  binding domain and a constant effector region devoid of a functional C H 1 domain; \n (b) cloning said recombined V H  heavy chain locus from an antibody-producing cell of said immunised transgenic rodent after affinity maturation via somatic mutation; and (c) producing said soluble, antigen specific heavy chain only antibody from the clone of step (b).

Metadata:
- Claim Count in Document: 83.0
- Percentile: 91.0
- Lexical Diversity: 2.14706
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13837520', '13837402', '14962335', '13259472', '13815812']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7773693424385512
- 35 USC 102 Novelty (BERT): 0.6730370445526479
- Combined Prediction Score: 0.7669361126499609
- Mean Citation Score: 522.33159
- Max Citation Score: 673.39166
- Similarity Product: 661.7521725983523

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test