PATENT CLAIM ANALYSIS

Application Number: 16058909
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["424", "400000"]

Abstract:
The present invention relates to methods for treating microbial infections on the surfaces of an implant or other surfaces near an implant in a patient. In particular, the methods are useful for treating biofilm infections. The methods include the use of minimally invasive techniques, including the use of ultra sound for facilitating the detection of biofilm infections on the implant or other surface of a patient and destroying the infection by administering an anthocyanin or an anthocyanidin or metabolite thereof. In particular, the administration of protocatechuic acid (PCA) or 2,4,6 trihydroxybenzaldehyde (2,4,6 THBA) for the treatment of an infected implant or other surface of a patient is described herein.

Claim (Index 27):
A method of treating a biofilm bacterial infection on a surface of an implant or a surface of a patient suspected of having a biofilm bacterial infection, the method comprising:\n a) performing a needle aspiration to determine a presence of a biofilm-forming bacteria around or on the surface of the implant or surface of the patient; b) culturing the biofilm-forming bacteria obtained from the needle aspiration to determine a presence of the biofilm-forming bacteria around or on the surface of the implant or surface of the patient; c) if the culture is negative, then an ultrasound is applied to dislodge the biofilm colony and biofilm-forming bacteria from the surface of the implant or the surface of the patient; d) if the culture is identified as positive, then administering to a surrounding space in proximity of the surface of the implant or the surface of a patient a solution comprising protocatechuic acid or 2,4,6-trihydroxybenzaldehyde or a mixture or combination thereof in an amount of about 0.25% to about 50% by weight or administering crystals of protocatechuic acid or 2,4,6-trihydroxybenzaldehyde or a mixture or combination thereof, which is effective to inhibit or destroy the biofilm colony and all biofilm-forming bacteria on the surface of the implant or the surface of the patient; and e) optionally applying ultrasound prior to performing the needle aspiration to dislodge the biofilm colony and facilitate release of a biofilm forming bacteria from the surface; wherein the surface of the patient is a closed wound, intact skin or skin having minimal exposure with a fistula; and wherein the implant is a medical device, a medical or surgical implant, a dental implant, total joint prosthesis, a catheter, or a heart or vascular graft.

Metadata:
- Claim Count in Document: 10.0
- Percentile: 96.0
- Lexical Diversity: 1.90476
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15789759', '15881177', '15484827', '15728760', '15787343']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8114453844196257
- 35 USC 102 Novelty (BERT): 0.5893376015334022
- Combined Prediction Score: 0.7892346061310033
- Mean Citation Score: 588.428134
- Max Citation Score: 613.40643
- Similarity Product: 392.7461704494238

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test