PATENT CLAIM ANALYSIS

Application Number: 15741963
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "394000"]

Abstract:
The present invention relates to a novel Ledipasvir (LDV) crystal form and a preparation method thereof. Specifically, disclosed is an LDV solvate. The solvate is a solvate formed by LDV and a solvent A and/or a solvent B, wherein the solvent A is acetonitrile or acetone; and the solvent B is methyl tertiary butyl ether (MTBE). Also disclosed are a preparation method and an application of the solvate. The solvate has a high purity, a good crystallization property, and better optical stability. The preparation method is simple and the process is stable. The solvate can significantly improve quality control and industrial applications of LDV-containing drugs.

Claim (Index 8):
A method for preparing a pharmaceutical composition, wherein comprising the steps of:\n 1) preparing a solid dispersion of Ledipasvir using the Ledipasvir solvate of  claim 1  as a raw material of the active ingredient Ledipasvir; 2) mixing the solid dispersion with a pharmaceutically acceptable carrier to prepare a pharmaceutical composition.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 86.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12257338', '14524686', '15753993', '15280321', '16096119']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7495254559178457
- 35 USC 102 Novelty (BERT): 0.4977658377573683
- Combined Prediction Score: 0.7243494941017979
- Mean Citation Score: 219.35183
- Max Citation Score: 228.48338
- Similarity Product: 156.36799723433973

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test