PATENT CLAIM ANALYSIS

Application Number: 15882724
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["424", "093210"]

Abstract:
The present disclosure relates to nucleic acid vaccine compositions and methods for preventing or treating pathological conditions, such as cancer or infectious disease. Further, the disclosure provides methods for more efficient production of antigens via mRNA containing one or more non-conventional start codons to promote multiplex initiation of translation in eukaryotic cells.

Claim (Index 18):
The method of  claim 1 , wherein the encoded fusion protein comprises:\n (a) a VSVG signal amino acid sequence as encoded by the polynucleotide of SEQ ID NO.:43 that is operably linked in frame to and disposed between the MTI sequence and the nucleic acid molecule encoding the fusion protein, optionally comprising a nucleic acid molecule encoding an amino acid cleavage sequence operably linked in frame to and disposed between the MTI sequence and the nucleic acid molecule encoding the VSVG signal amino acid sequence; (b) a VSVG trafficking amino acid sequence as encoded by the polynucleotide of SEQ ID NO.:47 or 48 that is operably linked in frame to the MTI sequence; (c) a VSVG membrane localization amino acid sequence as encoded by nucleotides 457 to 516 of SEQ ID NO.:57 that is operably linked in frame to the MTI sequence; (d) a VSVG trafficking amino acid sequence and membrane localization amino acid sequence as encoded by the polynucleotide of SEQ ID NO.:57 that is operably linked in frame to the MTI sequence; (e) any one of (a)-(d) further comprising a dendritic cell targeting amino acid sequence as encoded by the polynucleotide of SEQ ID NO.:45; or any one of (a) or (c)-(e) further comprising an intracellular trafficking sequence.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 86.0
- Lexical Diversity: 1.21739
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15222619', '15180852', '15222627', '14660924', '10343448']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8294717632620126
- 35 USC 102 Novelty (BERT): 0.6943856196176647
- Combined Prediction Score: 0.8159631488975778
- Mean Citation Score: 666.5319900000002
- Max Citation Score: 761.4291400000003
- Similarity Product: 712.4604865400031

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test