PATENT CLAIM ANALYSIS

Application Number: 15756367
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "300000"]

Abstract:
The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

Claim (Index 8):
A compound according to  claim 1 or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, or a solvate thereof, wherein: R 1  is independently selected from: \u2014(CH 2 ) 0-1 \u2014C 3-6  cycloalkyl, \u2014X 2 -(phenyl substituted with 0-1 R 6  and 0-2 R T ), \u2014CH((CH 2 )OSi(C 1-4  alkyl) 3 )-Ph, \u2014(CH 2 ) 0-1 -(naphthyl substituted with 0-1 R 6  and 0-1 R 7 ), \u2014(CH 2 ) 0-1 -(heterocycle substituted with 0-1 R 6  and 0-1 R 7 , wherein said heterocycle is selected from: pyrrolidinyl, oxazolyl, imidazolyl, pyrazolyl, 1-R b -pyrazolyl, thiazolyl, triazolyl, 1-R b -triazolyl, oxadiazolyl, pyridyl, benzothiazolyl, quinolinyl, and isoquinolinyl), X 2  is independently selected from: a bond, CH 2 , CH 2 CH 2 , and CH(C 1-4  alkyl substituted 0-1 OH); R 6  is, independently at each occurrence, selected from: OH, halogen, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, C 1-4  haloalkoxy, \u2014CH 2 OH, \u2014O(CH 2 ) 1-3 N(C 1-4  alkyl) 2 , CN, CO 2 H, NH 2 , \u2014CH 2 NH 2 , \u2014CH 2 N(C 1-4  alkyl) 2 , \u2014CH 2 NHCOCH 2 N(C 1-4  alkyl) 2 , CONR 8 R 9 , SO 2 (C 1-4  alkyl), C 3-6  cycloalkyl, \u2014O\u2014C 3-6  cycloalkyl, \u2014(CH 2 ) 0-1 \u2014(O) 0-1 \u2014(CH 2 ) 0-2 \u2014R 10 , \u2014CO\u2014R 10 , R 7  is, independently at each occurrence, selected from: halogen, CN, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, and C 1-4  haloalkoxy; R 8  is independently selected from: H, C 1-4  alkyl substituted with 0-1 OH, \u2014(CH 2 ) 1-3 N(C 1-4  alkyl) 2 , \u2014(CH 2 ) 1-3 CONH 2 , \u2014(CH 2 ) 0-2 \u2014R 10 , R 9  is independently selected from: H and C 1-4  alkyl; R 10  is independently selected from: phenyl substituted with 0-1 R 11  and 0-2 R a  and a heterocycle selected from: pyrrolidinyl, 1-R b -pyrrolidinyl, pyrazolyl, 1-R b -pyrazolyl, oxazolyl, isoxazolyl, imidazolyl, oxadiazolyl, thiazolyl, triazolyl, 1-R b -triazolyl, piperidinyl, 1-R b -piperidinyl, morpholinyl, 1-R b -morpholinyl, piperazinyl, 1-R b -piperazinyl, pyridyl, pyrazinyl, and pyrimidinyl; wherein said heterocycle is substituted with substituted with 0-1 R 11  and 0-2 R a ; R 11  is, independently at each occurrence, selected from: halogen, \u2550O, OH, CN, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  alkoxy, C 1-4  haloalkoxy, \u2014CH 2 OH, \u2014CH 2 OBn, CO 2 (C 1-4  alkyl), CON(C 1-4  alkyl) 2 , \u2014CH 2 NHCH 2 CO 2 (C 1-4  alkyl), and \u2014(CH 2 ) 0-1 -(phenyl substituted with 0-2 R a );\n R 12  is, independently at each occurrence, selected from: \u2014CO 2 CH 2 OCOCH 2 O(C 1-4  alkyl), \u2014CO 2 CH(C 1-4  alkyl)OCO(C 1-4  alkyl), and \n R a  is, independently at each occurrence, selected from: halogen, C 1-4  alkyl, and C 1-4  alkoxy; R b  is, independently at each occurrence, selected from: H, C 1-4  alkyl, \u2014(CH 2 ) 0-1 -(phenyl substituted with 0-1 R e ), \u2014(CH 2 ) 1-2 \u2014NH 2 , CO 2 (C 1-4  alkyl), CO 2 Bn, and pyridyl; and R e  is, independently at each occurrence, selected from: halogen, C 1-4  alkyl, and C 1-4  alkoxy.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.26829
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15756373', '15756378', '16099010', '13944921', '13936311']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7978892711262814
- 35 USC 102 Novelty (BERT): 0.6136078306489886
- Combined Prediction Score: 0.7794611270785522
- Mean Citation Score: 444.768054
- Max Citation Score: 554.2722
- Similarity Product: 483.51854830241206

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test