PATENT CLAIM ANALYSIS

Application Number: 15942345
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["540", "360000"]

Abstract:
A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA).

Claim (Index 7):
A compound selected from the group consisting of:\n n-(2-isothiocyanatoethyl)palmitamide; n-(2-isothiocyanatoethyl)-7-(naphthalene-2-yl)heptanamide; 1-isothiocyanato-2-(4-benzylpiperazino)ethane; 4-(4-(isothiocyanatomethyl)phenyl)morpholine; 4-benzyl-1-(2-isothiocyanatoethyl)piperidine; 4-(morpholinomethyl)benzylisothiocyanate; benzyl-4-(isothiocyanatomethyl)tetrahydro-1 (2h)-pyridinecarboxylate; 2-(4-(isothiocyanatomethyl)phenoxy)-6-methylpyrazine; 1-(isothiocyanatomethyl)-4-(phenoxymethyl)benzene; 2-(10-isothiocyanatodecyl)pyridine; 4-(10-isothiocyanatodecyl)pyridine; 2-(10-isothiocyanatodecyl)pyrimidine; ((2-(2-(2-isothiocyanatoethoxy)ethoxy)ethoxy)methyl)benzene; 3-((3-isothiocyanatopropoxy)methyl)-1,1\u2032-biphenyl; 4-((3-isothiocyanatopropoxy)methyl)-1,1\u2032-biphenyl; 1-((3-isothiocyanatopropoxy)methyl)-4-phenoxybenzene; 4-benzyl-1-(5-isothiocyanatopentyl)piperidine; 4-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)-4\u2032-methyl-1,1\u2032-biphenyl; 4-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-4\u2032-methyl-1,1\u2032-biphenyl; 4-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)-1,1\u2032-biphenyl; 4-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-1,1\u2032-biphenyl; 3,4\u2032-difluoro-4-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-1,1\u2032-biphenyl; 3,3\u2032-difluoro-4-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-4\u2032-methoxy-1,1\u2032-biphenyl; 4\u2032-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)-3-methoxy-1,1\u2032-biphenyl; 4\u2032-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-3-methoxy-1,1\u2032-biphenyl; 4-ethoxy-3,3\u2032-difluoro-4\u2032-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-1,1\u2032-biphenyl; 3,3\u2032-difluoro-4-isopropoxy-4\u2032-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-1,1\u2032-biphenyl; 6-(3-fluoro-4-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine; 5-(3-fluoro-4-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)phenyl)benzo[d][1,3]dioxole; 3-fluoro-4-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-3\u2032,4\u2032-dimethoxy-1,1\u2032-biphenyl; 3-(3-fluoro-4-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)phenyl)-2-methoxypyridine; 5-(3-fluoro-4-methoxyphenyl)-2-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)pyridine; 3,4\u2032-difluoro-3\u2032-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-4-methoxy-1,1\u2032-biphenyl; 4-bromo-2-fluoro-1-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)benzene; 4-(3-fluoro-4-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)phenyl)-3,5-dimethylisoxazole; 4-(3-fluoro-4-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)phenyl)-1-methyl-1h-pyrazole; 3-fluoro-4-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)-3\u2032-(trifluoromethyl)-1,1\u2032-biphenyl; 3\u2032-(benzyloxy)-3-fluoro-4-(((1R,3R)-3-isothiocyanatocyclobutoxy)methyl)-1,1\u2032-biphenyl; 2-bromo-1-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-4-phenoxybenzene; 4.2-(((1 S,3 S)-3-isothiocyanatocyclobutoxy)methyl)-5-phenoxy-1,1\u2032-biphenyl; 3-fluoro-4\u2032-((1R,3R)-3-isothiocyanatocyclobutoxy)-4-methoxy-1,1\u2032-biphenyl; 3-fluoro-4\u2032-((1 S,3 S)-3-isothiocyanatocyclobutoxy)-4-methoxy-1,1\u2032-biphenyl; (1R,3R)-n-([1,1\u2032-biphenyl]-4-ylmethyl)-3-isothiocyanato-n-methylcyclobutan-1-amine; (1 S,3 S)-n-([1,1\u2032-biphenyl]-4-ylmethyl)-3-isothiocyanato-n-methylcyclobutan-1-amine; (1R,3R)-n-(4-(benzo[d][1,3]dioxol-5-yl)benzyl)-3-isothiocyanato-n-methylcyclobutan-1-amine; (1R,3R)-n-(4-(benzo[d][1,3]dioxol-5-yl)benzyl)-n-ethyl-3-isothiocyanatocyclobutan-1-amine; 4-(((1 S,3 S)-3-(isothiocyanatomethyl)cyclobutoxy)methyl)-1,1\u2032-biphenyl; 4\u2032-(((3-isothiocyanatocyclohexyl)oxy)methyl)-3-(trifluoromethyl)-1,1\u2032-biphenyl; 3-fluoro-4\u2032-((((1R,4r)-4-isothiocyanatocyclohexyl)oxy)methyl)-4-methoxy-1,1\u2032-biphenyl; 1-bromo-4-((((1R,3R)-3-isothiocyanatocyclopentyl)oxy)methyl)benzene; (1R,2s)-1-isothiocyanato-2-((3\u2032-(trifluoromethyl)-[1,1\u2032-biphenyl]-4-yl)methoxy)-2,3-dihydro-1h-indene; (1 S,2R)-2-((3\u2032-fluoro-4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)-1-isothiocyanato-2,3-dihydro-1H-indene; 3-((4\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-([1,1\u2032-biphenyl]-4-ylmethoxy)azetidine-1-carbonitrile; 3-((2\u2032,4\u2032-dimethoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-([1,1\u2032-biphenyl]-3-ylmethoxy)azetidine-1-carbonitrile; 3-((3\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((2\u2032,5\u2032-dimethoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((2\u2032,3\u2032-dimethoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((3\u2032-(trifluoromethyl)-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((3\u2032,5\u2032-bis(trifluoromethyl)-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((4-(pyridin-3-yl)benzyl)oxy)azetidine-1-carbonitrile; 3-((4-(6-methoxypyridin-3-yl)benzyl)oxy)azetidine-1-carbonitrile; 3-((4-(2-methoxypyridin-3-yl)benzyl)oxy)azetidine-1-carbonitrile; 3-((2\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((4\u2032-methyl-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((4\u2032-fluoro-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((3-fluoro-3\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((3\u2032-methoxy-3-(trifluoromethyl)-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((3,3\u2032-dimethoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((4-phenoxybenzyl)oxy)azetidine-1-carbonitrile; 3-((1-(3\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)cyclopropyl)methoxy)azetidine-1-carbonitrile; 3-((2\u2032,6\u2032-dimethoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)azetidine-1-carbonitrile; 3-((3\u2032-(benzyloxy)-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile; 3-(([1,1\u2032-biphenyl]-4-ylmethoxy)methyl)azetidine-1-carbonitrile; 3-((5-phenoxy-[1,1\u2032-biphenyl]-2-yl)methoxy)azetidine-1-carbonitrile; 3-((2\u2032-methoxy-5-phenoxy-[1,1\u2032-biphenyl]-2-yl)methoxy)azetidine-1-carbonitrile; 3-((3\u2032-methoxy-5-phenoxy-[1,1\u2032-biphenyl]-2-yl)methoxy)azetidine-1-carbonitrile; 3-((4\u2032-methoxy-5-phenoxy-[1,1\u2032-biphenyl]-2-yl)methoxy)azetidine-1-carbonitrile; 3-((2-(2-methoxypyridin-3-yl)-4-phenoxybenzyl)oxy)azetidine-1-carbonitrile; 3-((4\u2032-cyano-5-phenoxy-[1,1\u2032-biphenyl]-2-yl)methoxy)azetidine-1-carbonitrile; 3-((2\u2032-cyano-5-phenoxy-[1,1\u2032-biphenyl]-2-yl)methoxy)azetidine-1-carbonitrile; 3-((4-(bis(4-fluorophenyl)methoxy)-2-bromobenzyl)oxy)azetidine-1-carbonitrile; 3-((3\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)-3-methylazetidine-1-carbonitrile; 3-((3\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)-3-phenylazetidine-1-carbonitrile; 3-((4-(benzo[d][1,3]dioxol-5-yl)benzyl)oxy)-3-phenylazetidine-1-carbonitrile; 3-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)-3-phenylazetidine-1-carbonitrile; 3-((4-bromophenyl)(phenyl)methoxy)azetidine-1-carbonitrile; 3-((3\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)(phenyl)methoxy)azetidine-1-carbonitrile; 3-((4-(3,5-dimethylisoxazol-4-yl)phenyl)(phenyl)methoxy)azetidine-1-carbo nitrile; 3-((4-(1-methyl-h-pyrazol-4-yl)phenyl)(phenyl)methoxy)azetidine-1-carbonitrile; 3-((4-(1-methyl-h-pyrazol-4-yl)phenyl)(phenyl)methoxy)azetidine-1-carbonitrile; 3-(([1,1\u2032-biphenyl]-4-ylmethyl)(methyl)amino)azetidine-1-carbonitrile; (S)-3-([1,1\u2032-biphenyl]-4-ylmethoxy)pyrrolidine-1-carbonitrile; (R)-3-([1,1\u2032-biphenyl]-4-ylmethoxy)pyrrolidine-1-carbonitrile; (1R,3R)-3-([1,1\u2032-biphenyl]-4-ylmethoxy)cyclobutane-1-carbonitrile; (1 S,3 S)-3-([1,1\u2032-biphenyl]-4-ylmethoxy)cyclobutane-1-carbonitrile; 2-(3-((3\u2032-methoxy-[1,1\u2032-biphenyl]-4-yl)methoxy)azetidin-1-yl)acetonitrile; 5-((2-bromo-4-phenoxybenzyl)oxy)picolinonitrile; 5-([1,1\u2032-biphenyl]-4-ylmethoxy)picolinonitrile; 5-([1,1\u2032-biphenyl]-4-ylmethoxy)-3-fluoropicolinonitrile; 3-([1,1\u2032-biphenyl]-4-ylmethoxy)-5-fluoropicolinonitrile; 5-phenylpentyl6-cyanopicolinate; 5-((6-phenylhexyl)oxy)pyrimidine-2-carbonitrile; 5-((5-phenylpentyl)oxy)pyrimidine-2-carbonitrile; 5-(2-(2-(benzyloxy)ethoxy)ethoxy)pyrimidine-2-carbonitrile; a tautomer thereof; a stereoisomer thereof; and a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.31034
- Patent Class: 540.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15311817', '15253773', '14770331', '15763724', '14169770']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7592322999820242
- 35 USC 102 Novelty (BERT): 0.6234728758042167
- Combined Prediction Score: 0.7456563575642434
- Mean Citation Score: 384.380926
- Max Citation Score: 623.34186
- Similarity Product: 505.3804367100835

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test