PATENT CLAIM ANALYSIS

Application Number: 16012468
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["514", "210210"]

Abstract:
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1)-mediated diseases or disorders: wherein R 1 , R 2 , R 3 , R 4 , and R 5  are as defined herein.

Claim (Index 1):
A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is selected from:\n C 1 -C 6  alkyl substituted with one to two R a , C 3 -C 6  cycloalkyl substituted with at least one group selected from \u2014C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, halo, OH, CN, \u2014C(O)R, \u2014C(O)OR, \u2014CONR 2 , \u2014NR\u2014C(O)R, \u2014NH 2 , \u2014NR\u2032 2 , \u2014NR\u2014C(O)OR\u2032, \u2014NR\u2014C(O)NR 2 , \u2014OC(O)NR 2 , \u2014NRSO 2 R\u2032, \u2014SO 2 R\u2032, and \u2014SO 2 NR 2 , and optionally further substituted with one to two R d ; \n 7-11 membered spiro cyclyl optionally substituted with one or two R b ; \n 7-11 membered spiro heterocyclyl comprising 1-2 heteroatoms selected from nitrogen, oxygen and sulfur, wherein the 7-11 membered spiroheterocyclyl is optionally substituted with one or two R b ; \n phenyl substituted with at least one group selected from \u2014NR\u2014C(O)OR\u2032, \u2014NR\u2014C(O)NR 2 , \u2014NR\u2014SO 2 R\u2032, \u2014NR\u2014SO 2 OR\u2032, \u2014NR\u2014SO 2 NR 2 , \u2014C(O)OH, \u2014SO 2 R\u2032, and \u2014SO 2 NR 2 , wherein the phenyl is further optionally substituted with one or two R b ; \n bicyclic heteroaryl comprising one to three heteroatoms selected from nitrogen, oxygen and sulfur, wherein the bicyclic heteroaryl is optionally substituted with one or two R b ; \n 2-pyridone optionally substituted with one or two R b ; \n 6-membered heteroaryl comprising one to two nitrogen atoms, wherein the 6-membered heteroaryl is substituted with at least one group selected from \u2014NR\u2014C(O)OR\u2032, \u2014NR\u2014C(O)NR 2 , \u2014NR\u2014SO 2 R\u2032, \u2014NR\u2014SO 2 OR\u2032, \u2014NR\u2014SO 2 NR 2 , \u2014C(O)OH, \u2014SO 2 R\u2032, and \u2014SO 2 NR 2 , and optionally further substituted with up to three R b ; \n \n optionally substituted with one or two R d ; and optionally substituted with one or two R d ; R 2  is selected from: H, halogen, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, \u2014C(O)OR, and \u2014C(O)NR 2 ; R 3  is selected from: R 4  is selected from: H, halogen and C 1 -C 4  alkyl; R 5  is selected from: H, halogen, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, and C 3 -C 6  cycloalkyl; R 6  is independently at each occurrence selected from: halogen, CN, OH, C 1 -C 4  alkyl, C 1 -C 4  alkoxyl, and C 1 -C 4  haloalkyl; R 7  is independently at each occurrence selected from: oxo, halogen, CN, OH, C 1 -C 4  alkyl, C 1 -C 4  alkoxyl, and C 1 -C 4  haloalkyl; U is selected from: CR 2 , NH, N\u2014(C 1-4  alkyl), N\u2014C(O)\u2014(C 1-4  alkyl), N\u2014C(O)\u2014NR 2 , and N\u2014C(O)\u2014O\u2014(C 1-4  alkyl); W is selected from: O, NH, N\u2014(C 1-4  alkyl), N\u2014SO 2 \u2014(C 1-4  alkyl), N\u2014C(O)\u2014(C 1-4  alkyl), N\u2014C(O)\u2014NR 2 , N\u2014SO 2 \u2014O\u2014(C 1-4  alkyl), N\u2014SO 2 \u2014NR 2 , and N\u2014C(O)\u2014O\u2014(C 1-4  alkyl); X is independently at each occurrence selected from: CR e R f , NR f  and 0; Y is independently at each occurrence selected from: CR e  and N; Z is selected from: CH, CR h  and N; R is independently at each occurrence selected from H and C 1 -C 4  alkyl; R\u2032 is independently at each occurrence C 1 -C 4  alkyl; R a  is independently selected from: halogen, \u2014OH, CN, \u2014SO 2 R\u2032, \u2014SO 2 NR 2 , \u2014NRSO 2 R\u2032, \u2014NR\u2014SO 2 OR\u2032, \u2014NR\u2014SO 2 NR 2 , \u2014NR 2 , \u2014NRC(O)R\u2032, \u2014NR\u2014C(O)NR 2 , \u2014NR\u2014C(O)OR\u2032, and \u2014C 1 -C 4  alkoxy, wherein the \u2014C 1 -C 4  alkoxy is substituted with at least one group selected from \u2014OH, halogen, and CN; R b  is independently selected from: halogen, C 1 -C 4  haloalkoxy, OH, CN, \u2014CO 2 R, \u2014C(O)NR 2 , \u2014CONRC(O)R\u2032, \u2014CONRSO 2 R\u2032, \u2014NR 2 , \u2014NRC(O)R, \u2014NR\u2014C(O)OR\u2032, \u2014NR\u2014C(O)NR 2 , \u2014SO 2 R\u2032, \u2014SO 2 NR 2 , \u2014NRSO 2 R\u2032, \u2014NR\u2014SO 2 OR\u2032, \u2014NR\u2014SO 2 NR 2 , C 1 -C 4  alkyl substituted with zero to one R c , and C 1 -C 4  alkoxy substituted with zero to one R c ; R c  is independently selected from: OH, C 1 -C 4  alkoxy, \u2014CO 2 R, \u2014C(O)NR 2 , \u2014NR 2 , and \u2014NRC(O)R; R d  is independently selected from: OH, \u2550O, \u2014C(O)R, and \u2014NH(C 1 -C 4  alkyl); R e  is independently at each occurrence selected from: H, halogen, CN, OH, C 1 -C 4  alkyl, and C 1 -C 4  haloalkyl; R f  is independently at each occurrence selected from: H, halogen, C 1 -C 4  alkyl, and C 1 -C 4  haloalkyl; R h  is independently at each occurrence selected from: halogen, CN, OH, C 1 -C 4  alkyl, and C 1 -C 4  haloalkyl; m is independently selected from: 0, 1, and 2; n, at each occurrence, is independently selected from: 0, 1, and 2; and p, at each occurrence, is independently selected from: 0, 1, and 2; provided that: when R 1  is C 1 -C 6  alkyl substituted with OH, R 2  is C 1 -C 4  alkyl substituted with one or two halogen; and when R 1  is C 3 -C 6  cycloalkyl substituted with OH, R 3  is selected from:

Metadata:
- Claim Count in Document: 5.0
- Percentile: 94.0
- Lexical Diversity: 1.30612
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16081543', '14977273', '15538348', '16311621', '16311575']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7518114130166437
- 35 USC 102 Novelty (BERT): 0.5575724154434728
- Combined Prediction Score: 0.7323875132593266
- Mean Citation Score: 363.655234
- Max Citation Score: 415.89038
- Similarity Product: 355.9305772307765

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test