PATENT CLAIM ANALYSIS

Application Number: 15744054
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["514", "019300"]

Abstract:
The present invention refers to new binding proteins based on di-ubiquitin modified in 12, 13, or 14 positions selected from positions R42, I44, H68, V70, R72, L73, R74, K82, L84, Q138, K139, E140, S141, and T142 of di-ubiquitin and being able to bind specifically with high affinity to selected targets. Furthermore, the invention provides a method for the generation of said binding proteins. In addition, libraries encoding for said binding proteins based on di-ubiquitin muteins modified in 12, 13, or 14 positions selected from R42, I44, H68, V70, R72, L73, R74, K82, L84, Q138, K139, E140, S141, and T142 are provided.

Claim (Index 7):
A binding protein comprising an amino acid sequence that is between 85% and 92% identical to SEQ ID NO: 4, wherein the binding protein comprises substitutions of 12-14 amino acids at a position selected from the group consisting of R42, I44, H68, V70, R72, L73, R74, K82, L84, Q138, K139, E140, S141, and T142 of SEQ ID NO: 4 and has a specific binding affinity for a target that is at least 10-fold higher than does a di-ubiquitin comprising SEQ ID NO: 4.

Metadata:
- Claim Count in Document: 54.0
- Percentile: 86.0
- Lexical Diversity: 2.22951
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14126358', '13144809', '14442376', '12293715', '13514133']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7193175700337051
- 35 USC 102 Novelty (BERT): 0.5274138560932669
- Combined Prediction Score: 0.7001271986396613
- Mean Citation Score: 294.255452
- Max Citation Score: 307.40186
- Similarity Product: 195.72801501467228

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test