PATENT CLAIM ANALYSIS

Application Number: 15992989
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "245000"]

Abstract:
The present invention relates to the use of substituted pyrimidine derivatives to modulate tropomyosin-related kinase (Trk) family protein kinase, and the use of the substituted pyrimidine derivatives for the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

Claim (Index 2):
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein:\n R 1  is selected from the group consisting of hydrogen, and C 1 -C 4  alkyl. \n R 2  is selected from the group consisting of hydrogen, NH 2 , and C 1 -C 4  alkyl. \n R 3  and R 4  are independently selected from the group consisting of hydrogen, F, CN, oxo, C 1 -C 4  alkyl, cycloalkyl, C 1 -C 6  alkoxy, C 2 -C 4  alkenyl, and C 2 -C 4  alkynyl; \n R 5  and R 6  are independently selected from the group consisting of hydrogen, F, Cl, Br, I, CN, C 1 -C 4  alkyl, C 1 -C 6  alkoxy, C 2 -C 6  alkenyl, CF 3 , CF 2 H, CFH 2 , C 2 -C 6  alkynyl, and CON(R 7 )R 8 ; \n R 7  and R 8  are independently selected from the group consisting of hydrogen, C 1 -C 4  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy, C 1 -C 6  alkylthio, C 2 -C 6  alkanoyl, C 1 -C 6  alkoxycarbonyl, and C 2 -C 6  alkanoyloxy; \n n=0-3; and \n X is selected from the group consisting of CH 2 , NR, O or S. R represents hydrogen, C 1 -C 4  alkyl, cycloalkyl, C 1 -C 6  alkoxy, C 2 -C 4  alkenyl, and C 2 -C 4  alkynyl; \n Het represents C 2 -C 8  heteroaryl, which is substituted with from 0 to 4 substituents independently chosen from the group consisting of:\n (1) halogen, hydroxy, amino, amide, cyano, \u2014COOH, \u2014SO 2 NH 2 , oxo, nitro and alkoxycarbonyl; \n (2) CON(R 7 )R 8 , N(R 7 )R 8 ; and \n (3) C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 10  aryl or heteroaryl, (C 3 -C 7  cycloalkyl)C 1 -C 4  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  alkylthio, C 2 -C 6  alkanoyl, C 1 -C 6  alkoxycarbonyl, C 2 -C 6  alkanoyloxy, mono- and di-(C 3 -C 8  cycloalkyl)aminoC 0 -C 4 alkyl, (4- to 7-membered heterocycle)C 0 -C 4 alkyl, C 1 -C 6  alkylsulfonyl, mono- and di-(C 1 -C 6  alkyl) sulfonamido, and mono- and di-(C 1 -C 6  alkyl)aminocarbonyl, each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxy, cyano, amino, \u2014COOH and oxo.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 93.0
- Lexical Diversity: 1.62
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15285234', '14440817', '14775434', '13377031', '13376814']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8154686687145241
- 35 USC 102 Novelty (BERT): 0.5174757499519397
- Combined Prediction Score: 0.7856693768382657
- Mean Citation Score: 314.521298
- Max Citation Score: 332.7134
- Similarity Product: 287.18529967801567

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test