PATENT CLAIM ANALYSIS

Application Number: 15771909
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "277000"]

Abstract:
The present invention relates to a cyclohexene derivative, a preparation method thereof, and a pharmaceutical composition for preventing or treating metabolic disease containing the cyclohexene derivative as an active ingredient. The cyclohexene derivative according to the present invention increases the intracellular activity of cyclic adenosine monophosphate (cAMP) by activating G protein-coupled receptor 119 (GPR-119) and simultaneously exhibits weight loss and hypoglycemic effects by inducing the release of glucagon-like peptide-1 (GLP-1), which is a neuroendocrine protein, and thus can be useful as a pharmaceutical composition for preventing or treating metabolic diseases such as obesity, type 1 diabetes, type 2 diabetes, inadequate glucose tolerance, insulin resistance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia and syndrome X.

Claim (Index 4):
The compound of Formula 1 or the isomer or pharmaceutically acceptable salt thereof according to  claim 1 , wherein the compound represented by Formula 1 is the compound selected from the group consisting of:\n (1) tert-butyl 4-((4-(4-((R)-1-hydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (2) tert-butyl 4-((4-(4-(cyclopropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (3) tert-butyl 4-((4-(4-(2,2-difluoroethylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (4) tert-butyl 4-((4-(4-((R)-2,3-dihydroxypropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (5) tert-butyl 4-((4-(4-((R)-3-hydroxypyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (6) tert-butyl 4-((4-(4-((3-hydroxypropyl)(methyl)carbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (7) tert-butyl 4-((4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (8) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N\u2014((R)-1-hydroxypropan-2-yl)cyclohex-3-enecarboxamide; (9) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(3-hydroxypropyl)cyclohex-3-enecarboxamide; (10) tert-butyl 4-((6-(4-((R)-2,3-dihydroxypropylcarbamoyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (11) tert-butyl 4-((6-(4-((S)-1-hydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (12) N\u2014((R)-2,3-dihydroxypropyl)-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (13) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(morpholino)methanone; (14) tert-butyl 4-((6-(4-(1,3-dihydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (15) N-(1,3-dihydroxypropan-2-yl)-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (16) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((R)-3-hydroxypyrrolidin-1-yl)methanone; (17) N\u2014((R)-2,3-dihydroxypropyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (18) N\u2014((S)-2,3-dihydroxypropyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (19) N\u2014((S)-1-hydroxypropan-2-yl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (20) N\u2014((R)-1-hydroxypropan-2-yl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (21) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-hydroxyethyl)-N-methylcyclohex-3-enecarboxamide; (22) N-(3-hydroxy-2,2-dimethylpropyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (23) N-(1,3-dihydroxypropan-2-yl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (24) tert-butyl 4-((5-(4-((S)-1-hydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (25) tert-butyl 4-((5-(4-((R)-1-hydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (26) tert-butyl 4-((5-(4-((S)-2-hydroxypropylcarbamoyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (27) tert-butyl 4-((5-(4-((R)-2-hydroxypropylcarbamoyl)cyclohex-1-enyl)pyridin-2-yl oxy)methyl)piperidine-1-carboxylate; (28) N\u2014((R)-2-hydroxypropyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (29) N\u2014((S)-2-hydroxypropyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (30) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N\u2014((R)-2-hydroxypropyl)cyclohex-3-enecarboxamide; (31) N-(2-hydroxyethyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (32) tert-butyl 4-((5-(4-((R)-2,3-dihydroxypropylcarbamoyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (33) tert-butyl 4-((5-(4-((S)-2,3-dihydroxypropylcarbamoyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidin-1-carboxylate; (34) N-(2-hydroxyethyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-methylcyclohex-3-enecarboxamide; (35) N-ethyl-N-(2-hydroxyethyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (36) N\u2014((R)-1-hydroxypropan-2-yl)-4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enecarboxamide; (37) N\u2014((S)-1-hydroxypropan-2-yl)-4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl) piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enecarboxamide; (38) N\u2014((R)-2-hydroxypropyl)-4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enecarboxamide; (39) N\u2014((S)-2-hydroxypropyl)-4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enecarboxamide; (40) N\u2014((R)-2,3-dihydroxypropyl)-4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enecarboxamide; (41) N\u2014((S)-2,3-dihydroxypropyl)-4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enecarboxamide; (42) tert-butyl 4-((5-(4-((S)-3-hydroxypyrrolidine-1-carbonyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (43) tert-butyl 4-((5-(4-((R)-3-hydroxypyrrolidine-1-carbonyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (44) tert-butyl 4-((2-fluoro-4-(4-((S)-3-hydroxypyrrolidine-1-carbonyl)cyclohex-1-en yl)phenoxy)methyl)piperidine-1-carboxylate; (45) tert-butyl 4-((2-fluoro-4-(4-((R)-3-hydroxypyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (46) N-(1,3-dihydroxypropan-2-yl)-4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enecarboxamide; (47) N-(3-hydroxy-2,2-dimethylpropyl)-4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enecarboxamide; (48) ((R)-3-hydroxypyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (49) ((S)-3-hydroxypyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (50) N-(2,2-difluoroethyl)-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (51) N-(2,2-difluoroethyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (52) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (53) ((S)-3-fluoropyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (54) ((R)-3-fluoropyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (55) (4-ethylpiperazin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (56) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(piperidin-1-yl)methanone; (57) tert-butyl 4-((2-fluoro-4-(4-((S)-3-fluoropyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (58) tert-butyl 4-((2-fluoro-4-(4-((R)-3-fluoropyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (59) tert-butyl 4-((2-fluoro-4-(4-((S)-1-hydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (60) tert-butyl 4-((2-fluoro-4-(4-((R)-1-hydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (61) tert-butyl 4-((2-fluoro-4-(4-((S)-2-hydroxypropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (62) tert-butyl 4-((2-fluoro-4-(4-((R)-2-hydroxypropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (63) tert-butyl 4-((4-(4-((S)-2,3-dihydroxypropylcarbamoyl)cyclohex-1-enyl)-2-fluorophenoxy)methyl)piperidine-1-carboxylate; (64) tert-butyl 4-((4-(4-((R)-2,3-dihydroxypropylcarbamoyl)cyclohex-1-enyl)-2-fluorophenoxy)methyl)piperidine-1-carboxylate; (65) azetidin-1-yl(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (66) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl) (morpholino)methanone; (67) tert-butyl 4-((4-(4-(1,3-dihydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)-2-fluorophenoxy)methyl)piperidine-1-carboxylate; (68) tert-butyl 4-((5-(4-(1,3-dihydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (69) tert-butyl 4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (70) tert-butyl 4-((5-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (71) tert-butyl 4-((2-fluoro-4-(4-(thiomorpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (72) tert-butyl 4-((5-(4-(thiomorpholine-4-carbonyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (73) tert-butyl 4-((2-fluoro-4-(4-(thiomorpholine-1,1-dioxide-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (74) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(thiomorpholino)methanone; (75) N-(2-fluoroethyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (76) tert-butyl 3-(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-methylcyclohex-3-enecarboxamido)propylcarbamate; (77) N-(3-aminopropyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-methylcyclohex-3-enecarboxamide; (78) 4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-(2,2,2-trifluoroethyl)cyclohex-3-enecarboxamide; (79) (4-ethylpiperazin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (80) N-(1,3-dihydroxypropan-2-yl)-4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (81) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-hydroxyethyl)-N-methylcyclohex-3-enecarboxamide; (82) tert-butyl 4-((2-fluoro-4-(4-(3-hydroxy-2,2-dimethylpropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (83) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N\u2014((S)-1-hydroxypropan-2-yl)cyclohex-3-enecarboxamide; (84) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N\u2014((R)-1-hydroxypropan-2-yl)cyclohex-3-enecarboxamide; (85) tert-butyl 4-((4-(4-(2,2-difluoroethylcarbamoyl)cyclohex-1-enyl)-2-fluorophenoxy)methyl)piperidine-1-carboxylate; (86) tert-butyl 4-((5-(4-(2,2,2-trifluoroethylcarbamoyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (87) tert-butyl 4-((5-(4-(2,2-difluoroethylcarbamoyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (88) tert-butyl 4-((5-(4-(2-fluoroethylcarbamoyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (89) (4-cyclopropylpiperazin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (90) tert-butyl 4-((5-(4-((R)-3-fluoropyrrolidine-1-carbonyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (91) tert-butyl 4-((5-(4-((S)-3-fluoropyrrolidine-1-carbonyl)cyclohex-1-enyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylate; (92) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-(2,2,2-trifluoroethyl)cyclohex-3-enecarboxamide; (93) N-(2,2-difluoroethyl)-4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (94) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-fluoroethyl)cyclohex-3-enecarboxamide; (95) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-3-fluoropyrrolidin-1-yl)methanone; (96) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl) ((R)-3-fluoropyrrolidin-1-yl)methanone; (97) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl) (morpholino)methanone; (98) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl) (thiomorpholino)methanone; (99) N-(2,2-difluoroethyl)-4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enecarboxamide; (100) (4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enyl)(morpholino)methanone; (101) ((R)-3-fluoropyrrolidin-1-yl)(4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enyl)methanone; (102) ((S)-3-fluoropyrrolidin-1-yl)(4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enyl)methanone; (103) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(2,2,2-trifluoroethyl)cyclohex-3-enecarboxamide; (104) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-fluoroethyl)cyclohex-3-enecarboxamide; (105) (2S)-1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)pyrrolidine-2-carboxamide; (106) (2S)-1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)pyrrolidine-2-carbonitrile; (107) tert-butyl 4-((4-(4-((S)-2-carbamoylpyrrolidine-1-carbonyl)cyclohex-1-enyl)-2-fluorophenoxy)methyl)piperidine-1-carboxylate; (108) (2S)-1-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)pyrrolidine-2-carboxamide; (109) (methyl 2-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamido)acetate; (110) ethyl 3-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamido)propanoate; (111) 3-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamido)propanoic acid; (112) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-morpholino-2-oxoethyl)cyclohex-3-enecarboxamide; (113) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-(3-morpholino-3-oxopropyl)cyclohex-3-enecarboxamide; (114) tert-butyl 4-((4-(4-((S)-2-cyanopyrrolidine-1-carbonyl)cyclohex-1-enyl)-2-fluorophenoxy)methyl)piperidine-1-carboxylate; (115) (2S)-1-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)pyrrolidine-2-carbonitrile; (116) (2R)-1-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)pyrrolidine-2-carboxamide; (117) (2R)-1-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)pyrrolidine-2-carbonitrile; (118) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((R)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone; (119) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone; (120) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-hydroxyethyl)cyclohex-3-enecarboxamide; (121) (2R)-1-(2-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamido)acetyl)pyrrolidine-2-carboxamide; (122) N-(2-((R)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)-4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (123) (4-cyclopropylpiperazin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (124) (4-(cyclopropylmethyl)piperazin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (125) tert-butyl 4-((3-fluoro-4-(4-((S)-2-hydroxypropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (126) tert-butyl 4-((3-fluoro-4-(4-((R)-2-hydroxypropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (127) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N\u2014((S)-1-hydroxypropan-2-yl)cyclohex-3-enecarboxamide; (128) N\u2014((S)-2,3-dihydroxypropyl)-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (129) tert-butyl 4-((3-fluoro-4-(4-((R)-1-hydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (130) tert-butyl 4-((3-fluoro-4-(4-((S)-1-hydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (131) tert-butyl 4-((4-(4-((R)-2,3-dihydroxypropylcarbamoyl)cyclohex-1-enyl)-3-fluorophenoxy)methyl)piperidine-1-carboxylate; (132) tert-butyl 4-((4-(4-((S)-2,3-dihydroxypropylcarbamoyl)cyclohex-1-enyl)-3-fluorophenoxy)methyl)piperidine-1-carboxylate; (133) (2S)-1-(2-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamido)acetyl)pyrrolidine-2-carboxamide; (134) (2S)-1-(3-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamido)propanoyl)pyrrolidine-2-carboxamide; (135) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-3-hydroxypyrrolidin-1-yl)methanone; (136) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N\u2014((S)-2-hydroxypropyl)cyclohex-3-enecarboxamide; (137) tert-butyl 4-((4-(4-(cyclopropylcarbamoyl)cyclohex-1-enyl)-3-fluorophenoxy)methyl)piperidine-1-carboxylate; (138) tert-butyl 4-((3-fluoro-4-(4-(2-fluoroethylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (139) N-(2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)-4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (140) N-(3-((S)-2-cyanopyrrolidin-1-yl)-3-oxopropyl)-4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (141) tert-butyl 4-((4-(4-(2,2-difluoroethylcarbamoyl)cyclohex-1-enyl)-3-fluorophenoxy)methyl)piperidine-1-carboxylate; (142) tert-butyl 4-((3-fluoro-4-(4-(2,2,2-trifluoroethylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (143) ((R)-3-(dimethylamino)pyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (144) ((S)-3-(dimethylamino)pyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (145) ((R)-3-(dimethylamino)pyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone hydrochloride; (146) ((S)-3-(dimethylamino)pyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone hydrochloride; (147) ((R)-2-(hydroxymethyl)pyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (148) ((S)-2-(hydroxymethyl)pyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (149) ((R)-3-(hydroxymethyl)pyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (150) ((S)-3-(hydroxymethyl)pyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (151) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((R)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone hydrochloride; (152) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-3-(hydroxymethyl)pyrrolidin-1-yl)methanone; (153) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((R)-3-(hydroxymethyl)pyrrolidin-1-yl)methanone; (154) ((S)-3-(dimethylamino)pyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (155) ((R)-3-(dimethylamino)pyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (156) ((S)-3-(dimethylamino)pyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone hydrochloride; (157) ((R)-3-(dimethylamino)pyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone hydrochloride; (158) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-3-(hydroxymethyl)pyrrolidin-1-yl)methanone hydrochloride; (159) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((R)-3-(hydroxymethyl)pyrrolidin-1-yl)methanone hydrochloride; (160) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-3-fluoropyrrolidin-1-yl)methanone; (161) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-3-fluoropyrrolidin-1-yl)methanone hydrochloride; (162) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (163) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(piperidin-1-yl)methanone; (164) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-hydroxypiperidin-1-yl)methanone; (165) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(hydroxymethyl)piperidin-1-yl)methanone; (166) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone hydrochloride; (167) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(piperidin-1-yl)methanone hydrochloride; (168) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-hydroxypiperidin-1-yl)methanone hydrochloride; (169) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(hydroxymethyl)piperidin-1-yl)methanone hydrochloride; (170) azetidin-1-yl(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (171) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(3-hydroxyazetidin-1-yl)methanone; (172) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone; (173) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(2-hydroxyethyl)piperidin-1-yl)methanone; (174) N-ethoxy-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (175) N-ethyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-hydroxyethyl)cyclohex-3-enecarboxamide; (176) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-hydroxyethyl)cyclohex-3-enecarboxamide; (177) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(3-hydroxy-2,2-dimethylpropyl)cyclohex-3-enecarboxamide; (178) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carboxamide; (179) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(3-methoxypropyl)cyclohex-3-enecarboxamide; (180) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(furan-2-ylmethyl)cyclohex-3-enecarboxamide; (181) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N,N-bis(2-hydroxyethyl)cyclohex-3-enecarboxamide; (182) (4-hydroxypiperidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (183) (4-(hydroxymethyl)piperidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (184) N-cyclopropyl-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (185) N-(3-hydroxypropyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (186) (4-(2-hydroxyethyl)piperidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (187) (4-(2-hydroxyethyl)piperazin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (188) 4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-(methoxymethyl)cyclohex-3-enecarboxamide; (189) N-cyclopropyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (190) tert-butyl 4-((4-(4-(2-hydroxyethylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (191) tert-butyl 4-((4-(4-(3-hydroxy-2,2-dimethylpropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (192) tert-butyl 4-((4-(4-(methoxymethylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (193) tert-butyl 4-((4-(4-(4-(pyrrolidin-1-yl)piperidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (194) tert-butyl 4-((4-(4-(cyclobutylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (195) tert-butyl 4-((4-(4-(cyclopentylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (196) tert-butyl 4-((4-(4-(4-morpholinopiperidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (197) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-methoxy-N-methylcyclohex-3-enecarboxamide; (198) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-methoxycyclohex-3-enecarboxamide; (199) tert-butyl 4-((4-(4-(ethyl(2-hydroxyethyl)carbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (200) tert-butyl 4-((4-(4-(4-(2-hydroxyethyl)piperidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (201) tert-butyl 4-((4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (202) tert-butyl 4-((4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (203) tert-butyl 4-((4-(4-(4-ethylpiperazine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (204) tert-butyl 4-((4-(4-(piperidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (205) tert-butyl 4-((4-(4-(3-ethoxypropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (206) tert-butyl 4-((4-(4-(bis(2-hydroxyethyl)carbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (207) 1-(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carboxamide; (208) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; (209) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-morpholinopiperidin-1-yl)methanone; (210) N-cyclopentyl-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (211) N-cyclobutyl-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (212) (3,4-dihydroisoquinolin-2(1H)-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (213) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone; (214) isoindolin-2-yl(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (215) 1,4\u2032-bipiperidin-V-yl(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (216) tert-butyl 4-((4-(4-(1,4\u2032-bipiperidine-1\u2032-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (217) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(3-(hydroxyimino)pyrrolidin-1-yl)methanone; (218) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; (219) 1,4\u2032-bipiperidin-1\u2032-yl(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (220) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-morpholinopiperidin-1-yl)methanone; (221) tert-butyl 4-((4-(4-(furan-2-ylmethylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (222) tert-butyl 4-((4-(4-(methoxycarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (223) tert-butyl 4-((4-(4-(methoxy(methyl)carbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (224) tert-butyl 4-((4-(4-(2,5-dihydro-1H-pyrrole-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (225) tert-butyl 4-((4-(4-(4-hydroxypiperidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (226) tert-butyl 4-((4-(4-(4-(hydroxymethyl)piperidine-1-carbon yl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (227) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carbonitrile; (228) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(spiro[indene-1,4\u2032-piperidin]-1-yl)methanone; (229) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone; (230) N-cyclopentyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (231) N-cyclobutyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (232) (3,4-dihydroisoquinolin-2(1H)-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (233) tert-butyl 4-((4-(4-(5-hydroxypentylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl) piperidine-1-carboxylate; (234) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(5-hydroxypentyl)cyclohex-3-enecarboxamide; (235) (2,5-dihydro-1H-pyrrol-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (236) tert-butyl 4-((4-(4-((2-hydroxyethyl)(methyl)carbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (237) tert-butyl 4-((4-(4-(1,3-dihydroxypropan-2-ylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (238) tert-butyl 4-((4-(4-(3-hydroxypropylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (239) tert-butyl 4-((4-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (240) tert-butyl 4-((4-(4-(isoindoline-2-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (241) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(isoindolin-2-yl)methanone; (242) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(3-hydroxypropyl)-N-methylcyclohex-3-enecarboxamide; (243) N-(3-hydroxypropyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-methylcyclohex-3-enecarboxamide; (244) N-(furan-2-ylmethyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (245) N-(3-ethoxypropyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (246) 4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-methoxycyclohex-3-enecarboxamide; (247) 4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-methoxy-N-methylcyclohex-3-enecarboxamide; (248) N,N-bis(2-hydroxyethyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (249) 1-(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carboxamide; (250) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)pyrrolidin-3-one; (251) 1-(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carboxamide; (252) 1-(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carboxamide; (253) (Z)-(3,3-bis(hydroxymethyl)-4-(methoxyimino)pyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (254) (Z)-tert-butyl 6-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)-8-(methoxyimino)-2,6-diazaspiro[3.4]octane-2-carboxylate; (255) (Z)-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(8-(methoxyimino)-2,6-diazaspiro[3.4]octan-6-yl)methanone hydrochloride; (256) tert-butyl 4-((4-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (257) tert-butyl 4-((4-(4-(3,3-difluoropyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (258) (3,3-difluoropyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (259) (3,3-difluoropyrrolidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (260) N-(5-hydroxypentyl)-4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (261) tert-butyl 4-((4-(4-(2,2,2-trifluoroethylcarbamoyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (262) tert-butyl 4-((4-(4-(4-cyanocyclohexanecarbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (263) tert-butyl 4-((4-(4-(1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (264) tert-butyl 4-((4-(4-(spiro[indene-1,4\u2032-piperidin]-1\u2032-ylcarbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (265) tert-butyl 4-((4-(4-(3-oxopyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (266) 1-(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carbonitrile; (267) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone; (268) (2,3-dihydrospiro[indene-1,4\u2032-piperidin]-1\u2032-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (269) (3-(ethoxyimino)pyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (270) tert-butyl 4-((4-(4-(4-(methoxyimino)piperidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (271) tert-butyl 4-((4-(4-(4-(hydroxyimino)piperidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (272) tert-butyl 4-((4-(4-(4-oxopiperidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (273) tert-butyl 4-((4-(4-(3-(methoxyimino)pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (274) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidin-4-one; (275) 1-(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidin-4-one; (276) (4-(hydroxyimino)piperidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (277) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(hydroxyimino)piperidin-1-yl)methanone; (278) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(methoxyimino)piperidin-1-yl)methanone; (279) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(methoxyimino)piperidin-1-yl)methanone; (280) tert-butyl 4-((4-(4-(3-oxoazetidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (281) tert-butyl 4-((4-(4-(3-(hydroxyimino)azetidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (282) tert-butyl 4-((4-(4-(3-(methoxyimino)azetidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (283) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)azetidin-3-one; (284) 1-(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)azetidin-3-one; (285) (3-(hydroxyimino)azetidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (286) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(3-(methoxyimino)azetidin-1-yl)methanone; (287) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(3-(methoxyimino)azetidin-1-yl)methanone; (288) tert-butyl 4-((4-(4-(3-hydroxyazetidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (289) (3-hydroxyazetidin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (290) (+)-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((R)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone; (291) (\u2212)-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((R)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone; (292) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(piperidin-1-yl)methanone; (293) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (294) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(4-hydroxypiperidin-1-yl)methanone; (295) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarbonyl)azetidin-3-one; (296) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(4-(2-hydroxyethyl)piperidin-1-yl)methanone; (297) 1,4\u2032-bipiperidin-1\u2032-yl(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)methanone; (298) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; (299) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(morpholino)methanone; (300) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(thiomorpholino)methanone; (301) azetidin-1-yl(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)methanone; (302) N-cyclopropyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarboxamide; (303) N-cyclobutyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarboxamide; (304) N-cyclopentyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarboxamide; (305) N-cyclohexyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarboxamide; (306) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone; (307) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-N-(2,2,2-trifluoroethyl)cyclohex-3-enecarboxamide; (308) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarbonyl)piperidin-4-one; (309) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(3-hydroxyazetidin-1-yl)methanone; (310) tert-butyl 4-((6-(4-(4-hydroxypiperidine-1-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (311) tert-butyl 4-((6-(4-(piperidine-1-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (312) tert-butyl 4-((6-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (313) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-N-(2-hydroxyethyl)cyclohex-3-enecarboxamide; (314) N-(2,2-difluoroethyl)-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarboxamide; (315) (4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (316) (4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(piperidin-1-yl)methanone; (317) (4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(morpholino)methanone; (318) (4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(thiomorpholino)methanone; (319) 1-(4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enecarbonyl)piperidine-4-carbonitrile; (320) (4-(2-hydroxyethyl)piperidin-1-yl)(4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)methanone; (321) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarbonyl)piperidine-4-carbonitrile; (322) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-N-(2-fluoroethyl)cyclohex-3-enecarboxamide; (323) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-N,N-bis(2-hydroxyethyl)cyclohex-3-enecarboxamide; (324) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarbonyl)piperidine-4-carboxamide; (325) tert-butyl 4-((6-(4-(4-(hydroxymethyl)piperidine-1-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (326) tert-butyl 4-((6-(4-(4-(2-hydroxyethyl)piperidine-1-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (327) tert-butyl 4-((6-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (328) tert-butyl 4-((6-(4-(thiomorpholine-4-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (329) (4-(hydroxymethyl)piperidin-1-yl)(4-(5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-2-yl)cyclohex-3-enyl)methanone; (330) azetidin-1-yl(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (331) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (332) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(piperidin-1-yl)methanone; (333) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(hydroxymethyl)piperidin-1-yl)methanone; (334) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(3-hydroxyazetidin-1-yl)methanone; (335) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(2-hydroxyethyl)piperidin-1-yl)methanone; (336) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; (337) (3-(hydroxyimino)azetidin-1-yl)(4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)methanone; (338) 1-(4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enecarbonyl)piperidine-4-carbonitrile; (339) azetidin-1-yl(4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)methanone; (340) tert-butyl 4-((6-(4-(4-cyanopiperadine-1-carbon yl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (341) tert-butyl 4-((6-(4-((2-hydroxyethyl)(methyl)carbamoyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (342) tert-butyl 4-((6-(4-(4-oxopiperidine-1-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (343) tert-butyl 4-((6-(4-(4-cyanopiperazine-1-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (344) tert-butyl 4-((6-(4-(4-(hydroxyimino)piperidine-1-carbonyl)cyclohex-1-enyl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate; (345) 1-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidin-4-one; (346) (4-ethylpiperazin-1-yl)(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (347) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(3-hydroxypropyl)piperazin-1-yl)methanone; (348) (4-cyclopropylpiperazin-1-yl)(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (349) (4-(6-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (350) (4-(6-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(piperidin-1-yl)methanone; (351) (4-(6-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(morpholino)methanone; (352) (4-(6-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(thiomorpholino)methanone; (353) (4-(6-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(4-hydroxypiperidin-1-yl)methanone; (354) (4-(6-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)(4-(hydroxymethyl)piperidin-1-yl)methanone; (355) (4-cyclopropylpiperazin-1-yl)(4-(6-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)pyridin-3-yl)cyclohex-3-enyl)methanone; (356) 4-(4-((1-(5-bromopyridin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-hydroxyethyl)cyclohex-3-enecarboxamide; (357) 4-(4-((1-(5-bromopyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-N-(2-hydroxyethyl)cyclohex-3-enecarboxamide; (358) N-(2-hydroxyethyl)-4-(4-((1-(pyridin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (359) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-N-(2-hydroxyethyl)-N-methylcyclohex-3-enecarboxamide; (360) N-ethyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-N-(2-hydroxyethyl)cyclohex-3-enecarboxamide; (361) 1-(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carboxamide; (362) 1,4\u2032-bipiperidin-1\u2032-yl(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (363) N-cyclopropyl-4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (364) N-cyclobutyl-4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (365) N-cyclopentyl-4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (366) N-cyclohexyl-4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarboxamide; (367) (4-ethylpiperazin-1-yl)(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (368) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(3-hydroxypropyl)piperazin-1-yl)methanone; (369) (4-cyclopropylpiperazin-1-yl)(4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (370) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone; (371) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N-(3-hydroxy-2,2-dimethylpropyl)cyclohex-3-enecarboxamide; (372) 4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)-N,N-bis(2-hydroxyethyl)cyclohex-3-enecarboxamide; (373) azetidin-1-yl(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)-3-(trifluoromethyl)phenyl)cyclohex-3-enyl)methanone; (374) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)-3-(trifluoromethyl)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (375) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-(trifluoromethyl)phenyl)cyclohex-3-enyl)(piperidin-1-yl)methanone; (376) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-N-(3-hydroxypropyl)-N-methylcyclohex-3-enecarboxamide; (377) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(4-(hydroxyimino)piperidin-1-yl)methanone; (378) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-N-(3-hydroxy-2,2-dimethylpropyl)cyclohex-3-enecarboxamide; (379) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(4-methylpiperazin-1-yl)methanone; (380) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(3-hydroxypropyl)piperazin-1-yl)methanone; (381) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(piperazin-1-yl)methanone; (382) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-methylpiperazin-1-yl)methanone; (383) tert-butyl 4-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enecarbonyl)piperazine-1-carboxylate; (384) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(4-methylpiperazin-1-yl)methanone; (385) 2-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-5-(4-(piperidine-1-carbonyl)cyclohex-1-enyl)benzonitrile; (386) 2-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-5-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)benzonitrile; (387) 5-(4-(azetidine-1-carbonyl)cyclohex-1-enyl)-2-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)benzonitrile; (388) 2-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-5-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)benzonitrile; (389) 2-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-5-(4-(thiomorpholine-4-carbonyl)cyclohex-1-enyl)benzonitrile; (390) 2-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-5-(4-(4-hydroxypiperidine-1-carbonyl)cyclohex-1-enyl)benzonitrile; (391) 2-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-5-(4-(4-(hydroxymethyl)piperidine-1-carbonyl)cyclohex-1-enyl)benzonitrile; (392) tert-butyl 4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (393) (4-(3-amino-4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (394) 2-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-5-(4-(4-(2-hydroxyethyl)piperidine-1-carbonyl)cyclohex-1-enyl)benzonitrile; (395) (4-cyclopropylpiperazin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (396) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-(trifluoromethyl)phenyl)cyclohex-3-enyl)(4-hydroxypiperidin-1-yl)methanone; (397) (4-cyclopropylpiperazin-1-yl)(4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)methanone; (398) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-(trifluoromethyl)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carbonitrile; (399) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-(trifluoromethyl)phenyl)cyclohex-3-enecarbonyl)piperidine-4-carboxamide; (400) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-(trifluoromethyl)phenyl)cyclohex-3-enyl)(morpholino)methanone; (401) isopropyl 4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (402) trichloromethyl 4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (403) phenyl 4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (404) 4-nitrophenyl 4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (405) 1,1,1,3,3,3-hexafluoropropan-2-yl 4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (406) 1,1,1-trifluoropropan-2-yl 4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (407) 1,3-difluoropropan-2-yl 4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (408) 1-methylcyclopropyl 4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (409) (4-(3-fluoro-4-((1-(1-(trifluoromethyl)cyclopentanecarbonyl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (410) (4-(4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(methoxyimino)piperidin-1-yl)methanone; (411) (4-(3-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(4-(hydroxyimino)piperidin-1-yl)methanone; (412) 4-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)-N-propylpiperazine-1-carboxamide; (413) 4-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)-N-isopropylpiperazine-1-carboxamide; (414) 1-(4-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enecarbonyl)piperazin-1-yl)-3-methylbut-2-en-1-one; (415) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-methylphenyl)cyclohex-3-enyl)(piperidin-1-yl)methanone; (416) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-methylphenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (417) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-methylphenyl)cyclohex-3-enyl)(morpholino)methanone; (418) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-methylphenyl)cyclohex-3-enyl)(thiomorpholino)methanone; (419) (4-(3-fluoro-4-((1-(2-fluoro-2-methylpropyl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (420) (4-(3-fluoro-4-((1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (421) (4-(3-fluoro-4-((1-(1-(trifluoromethyl)cyclopropanecarbonyl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (422) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(morpholino)methanone; (423) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(thiomorpholino)methanone; (424) 1-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enecarbonyl)piperidine-4-carbonitrile; (425) azetidin-1-yl(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)methanone; (426) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(piperidin-1-yl)methanone; (427) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)((R)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone; (428) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(4-methylpiperazin-1-yl)methanone; (429) (\u2212)-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (430) (\u2212)-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(4-(2-hydroxyethyl)piperidin-1-yl)methanone; (431) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(4-hydroxypiperidin-1-yl)methanone; (432) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(4-(hydroxymethyl)piperidin-1-yl)methanone; (433) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(4-hydroxypiperidin-1-yl)methanone; (434) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(piperazin-1-yl)methanone; (435) (4-(3-fluoro-4-((1-(3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(pyrrolidin-1-yl)methanone; (436) 2,2-difluoro-1-(4-((2-fluoro-4-(4-(pyrrolidine-1-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidin-1-yl)butan-1-one; (437) 4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)-N,N-bis(2-hydroxyethyl)cyclohex-3-enecarboxamide; (438) N-ethyl-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)-N-(2-hydroxyethyl)cyclohex-3-enecarboxamide; (439) 2,2-difluoro-1-(4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidin-1-yl)butan-1-one; (440) 1,1,1-trifluoropropan-2-yl 4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (441) (\u2212)-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-N-(2-hydroxyethyl)cyclohex-3-enecarboxamide; (442) (+)-tert-butyl 4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (443) (\u2212)-tert-butyl 4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (444) isopropyl 4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (445) phenyl 4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (446) 1,1,1,3,3,3-hexafluoropropan-2-yl 4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (447) 1,3-difluoropropan-2-yl 4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidine-1-carboxylate; (448) (4-(2-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl) (morpholino)methanone; (449) (4-(2-fluoro-4-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl) (thiomorpholino)methanone; (450) (4-(3-fluoro-4-((1-(1-(trifluoromethyl)cyclopentanecarbonyl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)(morpholino)methanone; (451) 1-(4-((2-fluoro-4-(4-(morpholine-4-carbonyl)cyclohex-1-enyl)phenoxy)methyl)piperidin-1-yl)-3-methylbut-2-en-1-one; (452) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(4-(trifluoromethyl)piperidin-1-yl)methanone; (453) (4,4-difluoropiperidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)methanone; (454) (3,3-difluoropyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)methanone; (455) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(3,3,4,4-tetrafluoropyrrolidin-1-yl)methanone; (456) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(4-(trifluoromethyl)piperidin-1-yl)methanone; (457) (4,4-difluoropiperidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)methanone; (458) ((\u2212)-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-3-fluoropyrrolidin-1-yl)methanone; (459) (3,3-difluoropyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)methanone; (460) (4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)cyclohex-3-enyl)(3,3,4,4-tetrafluoropyrrolidin-1-yl)methanone; (461) (\u2212)-(3,3-difluoropyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)methanone; (462) (+)-(3,3-difluoropyrrolidin-1-yl)(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)methanone; (463) (\u2212)-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(3,3,4,4-tetrafluoropyrrolidin-1-yl)methanone; (464) (+)-(4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)-2-fluorophenyl)cyclohex-3-enyl)(3,3,4,4-tetrafluoropyrrolidin-1-yl)methanone; (465) ((\u2212)-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone; and (466) ((+)-4-(4-((1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)cyclohex-3-enyl)((S)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 91.0
- Lexical Diversity: 1.58333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15307719', '13989611', '13997415', '14126685', '13377995']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7997644680344711
- 35 USC 102 Novelty (BERT): 0.6933148742536402
- Combined Prediction Score: 0.789119508656388
- Mean Citation Score: 452.684838
- Max Citation Score: 705.6704
- Similarity Product: 695.4419912937162

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test