PATENT CLAIM ANALYSIS

Application Number: 15877386
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["536", "023200"]

Abstract:
Provided are isolated nucleic acids for expressing lysosomal polypeptides such as lysosomal acid α-glucosidase (GAA) and vectors comprising the same. In one embodiment, the invention provides an isolated nucleic acid encoding a chimeric polypeptide comprising a secretory signal sequence operably linked to a lysosomal polypeptide. In another representative embodiment, an isolated nucleic acid is provided comprising a coding region encoding a GAA and a GAA 3′ untranslated region (UTR), wherein the GAA 3′ UTR comprises a deletion therein. In another representative embodiment, the invention provides an isolated nucleic acid comprising a coding region encoding a GAA and a 3′ UTR, wherein the 3′ UTR is less than about 200 nucleotides in length and comprises a segment that is heterologous to the GAA coding region. Also provided are methods of making and using delivery vectors encoding lysosomal polypeptides, for example, to produce the lysosomal polypeptide or to treat subjects afflicted with a deficiency in the lysosomal polypeptide.

Claim (Index 12):
The vector of  claim 10 , wherein the secretory signal sequence is derived from SP38, erythropoietin albumin, albumin, or coagulation factor IX.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 86.0
- Lexical Diversity: 2.26316
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13403783', '10511980', '12801404', '14936568', '13253005']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7026382838247164
- 35 USC 102 Novelty (BERT): 0.605520112892547
- Combined Prediction Score: 0.6929264667314995
- Mean Citation Score: 528.7380059999998
- Max Citation Score: 829.1637599999997
- Similarity Product: 467.2436030651091

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test