PATENT CLAIM ANALYSIS

Application Number: 15906170
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["506", "007000"]

Abstract:
Disclosed herein are biomarkers related to gastric cancer. The presently identified salivary biomarkers create the basis for a gastric cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed gastric cancer assay in clinical, diagnostic and therapeutic uses is also included.

Claim (Index 17):
A kit selected from the group consisting of:\n a) a kit comprising a solid support, wherein the solid support comprises a capture binding probe selective for at least two biomarkers selected from the group consisting of Annexin 1 (ANXA1), Cystatin/Stefin B (CSTB), Semaphorin 4B (SEMA4B), S100 calcium binding protein A10 (S100A10), Periplakin (PPL), Serine peptidase inhibitor, Kazal type 7 (SPINK7), EROL-like, RAN binding protein 9 (RANBP9), CD24, Keratin 6A (KRT6A), Keratin 4 (KRT4), eukaryotic translation initiation factor 3 subunit G (EIF3G), triophosphate isomerase 1 (TPL1), Cystatin-B (CSTB), deleted in malignant brain tumors 1 protein (DMBT1),  Neisseria  sp strain (B33KA_ot020_Y56,  Eikenella corrodens  and  Kingella dentriflicans  and sp clone (DE012_0t012_577_582_AD98,  Streptococcus australis  and sp clone (FN04_ot65_073_Ab83),  Fusobacterium  all species (AD99), miR-140-5p, miR-374a, miR-454, miR-15b, miR-28-5p, or miR-301a; and b) a kit comprising one or more primers for the selective amplification of at least two biomarkers selected from the group consisting of Annexin 1 (ANXA1), Cystatin/Stefin B (CSTB), Semaphorin 4B (SEMA4B), S100 calcium binding protein A10 (S100A10), Periplakin (PPL), Serine peptidase inhibitor, Kazal type 7 (SPINK7), EROL-like, RAN binding protein 9 (RANBP9), CD24, Keratin 6A (KRT6A), Keratin 4 (KRT4), eukaryotic translation initiation factor 3 subunit G (EIF3G),  Neisseria  sp strain (B33KA_ot020_Y56,  Eikenella corrodens  and  Kingella dentriflicans  and sp clone (DE012_0t012_577_582_AD98,  Streptococcus australis  and sp clone (FN04_ot65_073_Ab83),  Fusobacterium  all species (AD99), miR-140-5p, miR-374a, miR-454, miR-15b, miR-28-5p, or miR-301a, wherein each of the primers optionally comprises a detectable label.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 88.0
- Lexical Diversity: 1.33333
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13607236', '13639756', '14265337', '13009393', '14112684']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5904431787637535
- 35 USC 102 Novelty (BERT): 0.6271135293376464
- Combined Prediction Score: 0.5941102138211428
- Mean Citation Score: 339.451742
- Max Citation Score: 810.4442
- Similarity Product: 508.20993806726926

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test