PATENT CLAIM ANALYSIS

Application Number: 15753318
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["435", "440000"]

Abstract:
Chromatin 3D structure modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs, such as CTCF motifs. In certain example embodiments, the present invention may block formation of an loop anchor or chromatin domain or induce formation of a loop anchor or chromatin domain at a targeted genomic location. For instance, a loop anchor motif can be altered, such as by mutating (including inverting) a binding motif so as to remove such a motif, or by adding new binding motifs in new locations within a loop domain, so as to reduce the size of an existing loop, so as to modify the size of an existing loop, or combinations thereof. Alternatively, the chromatin 3D structure modulating agent may bind a target region and mask a loop anchor motif, thereby preventing a loop anchor or chromatin domain from forming. The chromatin 3D structure modulating agent may bind a target region and cause a loop anchor of chromatin domain to form.

Claim (Index 11):
The method of  claim 2 , wherein said targeted removal, modification or introduction comprises:\n i. genome editing; and/or ii. the use of a CRISPR-Cas system, an inactivated CRISPR-Cas system, a Cas protein, a zinc finger protein (ZFP), a zinc finger nuclease (ZFN), a transcription activator-like effector (TALE), a transcription activator-like effector nuclease (TALEN), or a meganuclease.

Metadata:
- Claim Count in Document: 72.0
- Percentile: 88.0
- Lexical Diversity: 2.30864
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14892911', '14916338', '15179912', '14105017', '15527790']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5350267936416635
- 35 USC 102 Novelty (BERT): 0.5043676303507956
- Combined Prediction Score: 0.5319608773125767
- Mean Citation Score: 257.984156
- Max Citation Score: 263.11386
- Similarity Product: 187.2931283535576

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test