PATENT CLAIM ANALYSIS

Application Number: 16153108
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-03
Patent Classification: ["435", "006120"]

Abstract:
Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g., translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5′ and 3′ regions of the gene. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5′ portion of a target gene relative to the 3′ region of the target gene.

Claim (Index 22):
The method of  claim 21 , wherein the amplifying is performed by real time RT-PCR and the relative expression is determined as an IDE Score using a formula selected from the group consisting of\n ( Ct 3\u2032-target gene )\u2212( Ct 5\u2032-target gene ) IDE Score=2, and (3\u2032 Target)/(5\u2032 Target) \n wherein Ct denotes threshold cycle, 3\u2032 Target denotes the expression level of the 3\u2032 region of the target gene, and 5\u2032 Target denotes the expression level of the 5\u2032 region of the target gene.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 97.0
- Lexical Diversity: 1.62069
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13848974', '15372752', '12786266', '14454124', '14699380']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7411554653853902
- 35 USC 102 Novelty (BERT): 0.6181597186773101
- Combined Prediction Score: 0.7288558907145822
- Mean Citation Score: 565.607158
- Max Citation Score: 586.93024
- Similarity Product: 513.4395577193451

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test