PATENT CLAIM ANALYSIS

Application Number: 16073809
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["544", "262000"]

Abstract:
The present invention relates to a process for the preparation of 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib of Formula (I). The present invention further relates to a process for the preparation highly pure 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib(I)

Claim (Index 1):
A process for the preparation of Ibrutinib (I) comprising the steps of:\n a) reacting 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (II) with an activated (S)-N-protected piperidin-3-yl (III) to yield (R)-1-(1-protected piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (IV) \n wherein Ac is activated group selected from O-Acyl, O-sulfonyl, O-Akyl, O-Aryl, orthomestylate, orthotosylate, orthobesylate; P is an amino protecting group selected from benzyl, benzoyl, acyl, tosyl, sulfonyl, trityl, carbamyl, Aryl oxy, Cbz. b) deprotecting (R)-1-(1-protected piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (IV) to yield (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (V); c) reacting the compound of Formula V with Acrylic acid to yield Ibrutinib

Metadata:
- Claim Count in Document: 4.0
- Percentile: 95.0
- Lexical Diversity: 2.33333
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16074505', '13859569', '14418484', '13908949', '14374788']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7174034093832818
- 35 USC 102 Novelty (BERT): 0.5637897930141287
- Combined Prediction Score: 0.7020420477463666
- Mean Citation Score: 379.26753
- Max Citation Score: 448.23163
- Similarity Product: 362.25134642821314

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test