PATENT CLAIM ANALYSIS

Application Number: 16018540
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["435", "252300"]

Abstract:
The present disclosure provides bacteria with improved membrane integrity related primarily to outer membrane protein content and increased fatty acid production. According to the invention, Applicants have successfully demonstrated that modulation of membrane protein FADL increased membrane integrity and final fatty acid titre by 34%, Surprisingly, applicants also showed that combining the FADL regulation with a decrease or inactivation of OmpF in bacterial membranes resulted in a synergistic increase of 53% fatty acid production. The invention also provides for an isolated or recombinant bacterium, and use of the same for fatty acid production.

Claim (Index 21):
A method for altering fatty acids content as compared to wild-type, in a microbe, the method comprising transforming the microbe with a nucleotide construct comprising a polynucleotide construct for increasing FADL abundance/activity in an outer membrane, and a polynucleotide construct for decreasing OmpF abundance/activity in an outer membrane.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 94.0
- Lexical Diversity: 1.61905
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14709232', '13494709', '12889066', '14040371', '15114502']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5509142283014657
- 35 USC 102 Novelty (BERT): 0.5090033921334284
- Combined Prediction Score: 0.546723144684662
- Mean Citation Score: 255.391078
- Max Citation Score: 257.3623
- Similarity Product: 174.85917865142827

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test