PATENT CLAIM ANALYSIS

Application Number: 16161198
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "210000"]

Abstract:
The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

Claim (Index 11):
The method according to  claim 1  selected from the following group:\n 4-(1-phenylethoxy)-3-(piperidin-4-ylmethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-(2-hydroxyethoxy)-4-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 5-chloro-6-(2-(dimethylamino)-1-(pyridin-2-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 3-methoxy-4-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(1-(pyridin-2-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 4-(2-(dimethylamino)-1-phenylethoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(2-hydroxy-1-phenylethoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 4-(3-hydroxy-1-phenylpropoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(1-phenyl-3-(pyrrolidin-1-yl)propoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(1-phenyl-2-(pyrrolidin-1-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(3-(dimethylamino)-1-phenylpropoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(2-(methylamino)-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(1-(pyridin-3-yl)ethoxy)-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n N-(5-(3-fluoropyridin-4-yl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-(1-(pyridin-3-yl)ethoxy)benzamide; \n 3-methoxy-N-(5-(3-methylpyridin-4-yl)-1,3,4-thiadiazol-2-yl)-4-(1-phenylethoxy)benzamide; \n 3-methoxy-N-(5-(2-methylpyridin-4-yl)-1,3,4-thiadiazol-2-yl)-4-(1-phenylethoxy)benzamide; \n 4-((1H-imidazol-4-yl)methoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-4-(pyrimidin-2-ylmethoxy) benzamide; \n 3-methoxy-4-((1-methyl-1H-imidazol-2-yl)methoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 5-methyl-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-chloro-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-((2-methoxyethyl)amino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(benzyloxy)-5-chloro-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(benzyloxy)-5-(4-methylpiperazin-1-yl)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 5-methoxy-6-((1-phenylethyl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(3-(dimethylamino)-1-phenylpropoxy)-5-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2-hydroxy-1-phenylethoxy)-5-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2-hydroxy-2-phenylethoxy)-5-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-chloro-6-(2-hydroxy-2-methyl-1-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-chloro-6-(2-(dimethylamino)-1-(pyridin-2-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2-(dimethylamino)-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-((1-(dimethylamino)-2,3-dihydro-1H-inden-2-yl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-((1-(dimethylamino)-3-phenylpropan-2-yl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-((1-phenylpropan-2-yl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(1-(pyridin-3-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-((1-(pyridin-3-yl)ethyl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-5-((tetrahydro-2H-pyran-4-yl)methoxy)nicotinamide; \n 6-(3-morpholino-1-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-(2-morpholino-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 4-(isoindolin-2-ylmethyl)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 6-(benzyloxy)-5-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-methoxy-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 2-methyl-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 2-methyl-6-(1-(pyridin-2-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-(benzyloxy)-2-methyl-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-methoxy-6-(1-(pyridin-2-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 5-chloro-6-(1-(pyridin-2-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-(benzyloxy)-5-((2-(dimethylamino)ethyl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(benzyloxy)-5-methyl-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-((2-(dimethylamino)ethyl)amino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-5-(((tetrahydro-2H-pyran-4-yl)methyl)amino)nicotinamide; \n 5-(((1-methylpiperidin-4-yl)methyl)amino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-(methylamino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-(benzyloxy)-5-(methylamino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(3-(dimethylamino)-1-phenylpropoxy)-5-methyl-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-chloro-6-(3-(dimethylamino)-1-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2-(dimethylamino)-1-phenylethoxy)-5-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-chloro-6-(2-(dimethylamino)-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2-(dimethylamino)-1-phenylethoxy)-5-methyl-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-((3-(dimethylamino)propyl)amino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-((2-hydroxyethyl)amino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-(((1-methyl-1H-imidazol-4-yl)methyl)amino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-((1-methylpiperidin-4-yl)amino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-((2-morpholinoethyl)amino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-(4-methylpiperazin-1-yl)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-(dimethylamino)-6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-methoxy-6-((1-(pyridin-3-yl)ethyl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2-(dimethylamino)-1-(pyridin-2-yl)ethoxy)-5-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-(dimethylamino)-6-(3-(dimethylamino)-1-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(3-(dimethylamino)-1-phenylpropoxy)-5-(methylamino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-4-(pyridin-4-ylmethoxy)benzamide; \n 3-methoxy-4-(1-(pyridin-3-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-((2,3-dihydro-1H-inden-1-yl)oxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-4-((1,2,3,4-tetrahydronaphthalen-1-yl)oxy)benzamide; \n 3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-4-(thiazol-4-ylmethoxy) benzamide; \n 3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-4-(thiazol-2-ylmethoxy) benzamide; \n 3-(2-(dimethylamino)ethoxy)-4-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-(2-methoxyethoxy)-4-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 3-((1-methylpiperidin-4-yl)methoxy)-4-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((2-methylpyridin-3-yl)methoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((5-methylpyridin-2-yl)methoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((5-methylisoxazol-3-yl)methoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((4-methoxybenzyl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 4-((2-fluorobenzyl)oxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 3-methoxy-4-(pyridin-2-ylmethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 4-((4-fluorobenzyl)oxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 3-methoxy-4-((5-methyl-1,2,4-oxadiazol-3-yl)methoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-((5-cyclopropylisoxazol-3-yl)methoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((1-methyl-1H-imidazol-5-yl)methoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(2-(1-methyl-1H-imidazol-2-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(1-(pyridin-2-yl)ethoxy)-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n N-(5-(3-fluoropyridin-4-yl)-1,3,4-thiadiazol-2-yl)-3-methoxy-4-(1-(pyridin-2-yl) ethoxy)benzamide; \n N-(5-(3-fluoropyridin-4-yl)-1,3,4-thiadiazol-2-yl)-4-(3-hydroxy-1-phenylpropoxy)-3-methoxybenzamide; \n N-(5-(3-fluoropyridin-4-yl)-1,3,4-thiadiazol-2-yl)-4-(2-hydroxy-1-phenylethoxy)-3-methoxybenzamide; \n 4-(2-(dimethylamino)-1-phenylethoxy)-N-(5-(3-fluoropyridin-4-yl)-1,3,4-thiadiazol-2-yl)-3-methoxybenzamide; \n 6-(3-(dimethylamino)-1-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-5-((tetrahydro-2H-pyran-4-yl)methoxy)nicotinamide; \n 5-chloro-6-(2-hydroxy-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 4-(3-hydroxy-1-phenylpropoxy)-3-methoxy-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(2-hydroxy-1-phenylethoxy)-3-methoxy-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(benzyloxy)-3-methoxy-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(benzyloxy)-N-(5-(3-fluoropyridin-4-yl)-1,3,4-thiadiazol-2-yl)-3-methoxybenzamide; \n 4-(2-(dimethylamino)-1-phenylethoxy)-3-methoxy-N-(5-(3-methylpyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 6-(2-(dimethylamino)-1-phenylethoxy)-5-methoxy-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 4-(2-(dimethylamino)-1-phenylethoxy)-3-methoxy-N-(5-(2-methylpyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((1-phenylpropan-2-yl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 4-(2-(dimethylamino)-1-phenylethoxy)-3-methoxy-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(benzyloxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((methyl(pyridin-2-yl)amino)methyl)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-((1H-indol-1-yl)methyl)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 3-methoxy-4-(phenoxymethyl)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((methyl(phenyl)amino)methyl)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 6-(2-hydroxy-2-methyl-1-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-((1-phenylpropan-2-yl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)-6-(thiophen-3-ylmethoxy)nicotinamide; \n 6-(3-(dimethylamino)-1-phenylpropoxy)-N-(5-(3-fluoropyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(1-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(1-(4-chlorophenyl)propoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2,3-dihydro-1H-inden-1-yl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-((6,7-dihydro-5H-cyclopenta[b]pyridin-5-yl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(3-(dimethylamino)-1-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-(3-hydroxy-3-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(benzyloxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(methyl(1-phenylethyl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-((2-(dimethylamino)-2-phenylethyl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2,3-dihydro-1H-inden-2-yl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-((1-(pyridin-2-yl)ethyl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-((1-(pyridin-3-yl)propan-2-yl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 6-((1-phenylethyl)amino)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 4-((6,7-dihydro-5H-cyclopenta[b]pyridin-5-yl)oxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-((2,3-dihydrobenzofuran-3-yl)oxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(cyclopropyl(phenyl)methoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 3-methoxy-4-(1-phenylethoxy)-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-((2,3-dihydro-1H-inden-2-yl)oxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(1-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-phenethoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-((1-methyl-1H-pyrazol-3-yl)methoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(pyridin-3-ylmethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 4-(benzyloxy)-3-chloro-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(benzyloxy)-2-chloro-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(pyridin-3-ylmethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(benzyloxy)-2-fluoro-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(benzyloxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-phenoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 6-phenoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-((1-(dimethylamino)-1-oxo-3-phenylpropan-2-yl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-((4-phenylbutan-2-yl)oxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2-phenylpropoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(3-(4-methoxyphenyl)propoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 5-methyl-6-(2-morpholino-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 3-methoxy-4-(2-methoxy-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) benzamide; \n 3-methoxy-4-(2-morpholino-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-methoxy-4-(2-morpholino-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 6-(3-(dimethylamino)-1-phenylpropoxy)-5-methoxy-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2-(3,3-difluoropyrrolidin-1-yl)-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(2-(4-methylpiperazin-1-yl)-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 6-(1-phenyl-3-(pyrrolidin-1-yl)propoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 5-methoxy-6-(1-phenyl-2-(pyrrolidin-1-yl)ethoxy)-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-methoxy-6-(1-phenyl-2-(pyrrolidin-1-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-methyl-6-(1-phenyl-2-(pyrrolidin-1-yl)ethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)nicotinamide; \n 5-methoxy-6-(1-phenylethoxy)-N-(5-(pyrimidin-4-yl)-1,3,4-thiadiazol-2-yl) nicotinamide; \n 4-(2-(dimethylamino)-1-phenylethoxy)-3-fluoro-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 3-chloro-4-(2-(dimethylamino)-1-phenylethoxy)-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; \n 4-(1-(4-fluorophenyl)-2-hydroxyethoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide; and \n 4-(2-(dimethylamino)-1-(4-fluorophenyl)ethoxy)-3-methoxy-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)benzamide.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 97.0
- Lexical Diversity: 1.16216
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15536800', '13120436', '13755387', '14750019', '13120440']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7428956883149689
- 35 USC 102 Novelty (BERT): 0.6368874805495754
- Combined Prediction Score: 0.7322948675384295
- Mean Citation Score: 405.248922
- Max Citation Score: 603.7789
- Similarity Product: 537.1757867190004

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test