PATENT CLAIM ANALYSIS

Application Number: 15877215
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "006100"]

Abstract:
Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors and their use in assays that may be used to discover compounds that modulate (blocking, enhancing, masking or mimicking compounds) their activity. Orphan mouse odorant receptors are identified from olfactory sensory neurons that respond to target compounds. The resulting receptors as well as their human counterparts can be screened in assays against test compounds to confirm their identity as odorant or aroma receptors, particularly malodor receptors and subsequently discover for example modulators that inhibit the perception of the malodor in humans.

Claim (Index 1):
A method of identifying olfactory receptors that are activated by an odor and/or aroma compound comprising:\n a) dissociating an isolated olfactory epithelium containing native olfactory neurons into a single cell from a non-human mammal species wherein each neuron expresses the olfactory receptor; b) loading the olfactory cells with an indicator dye that allows for the measurement of malodor receptor binding activity of the olfactory receptors; c) contacting the olfactory receptors with malodor compounds; d) measuring changes of odorant-induced neuronal activity; e) isolating one or more olfactory neurons that were activated by the malodor compound; f) isolating or isolating and amplifying the mRNA of the isolated olfactory receptors; g) sequencing at least a portion of the entire transcriptome of the mRNA by Next-Generation Sequencing; and h) identifying a group of malodor olfactory receptors by comparing the sequence of the transcriptome to a reference genome sequence of the same species.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 86.0
- Lexical Diversity: 1.57746
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14318641', '10300846', '14118414', '13024325', '15506266']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6271453582609481
- 35 USC 102 Novelty (BERT): 0.5633504511558933
- Combined Prediction Score: 0.6207658675504426
- Mean Citation Score: 335.762694
- Max Citation Score: 500.6953
- Similarity Product: 342.20192551039463

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test