PATENT CLAIM ANALYSIS

Application Number: 15537087
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-01
Patent Classification: ["536", "028500"]

Abstract:
This disclosure relates to N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment and prophylaxis of viral infections.

Claim (Index 19):
A method of treating or preventing a human coronavirus, SARS coronavirus, MERS coronavirus, Eastern equine encephalitis virus, Western equine encephalitis virus, Venezuelan equine encephalitis virus, Chikungunya virus, and Ross River infection infection, orthomyxoviridae virus or paramyxoviridae virus or RSV virus, or influenza virus, or filoviridae virus or ebola virus infection in a patient comprising administering in effective amount of a compound with the formula: or salts thereof, wherein V is absent, O, NH, NR 15 , S, CH 2 , or CHR 15 ; X is CH 2 , CHMe, CMe 2 , CHF, CF 2 , or CD 2 ; Y is H, D, F, Cl, Br, I, CH 3 , CD 3 , CF 3 , alkyl, acyl, alkenyl, alkynyl, hydroxyl, formyl or SCH 3 ; R 1  is hydrogen, monophosphate, diphosphate, triphosphate, alkyl,\n halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, carbanoyl, esteryl, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl, phosphoramidyl, or phosphate wherein R 1  is optionally substituted with one or more, the same or different, R 20 ; \n Y 1  is O or S; \n Y 2  is OH, OR 12 , OAlkyl, or BH 3 \u2212 M + ; \n Y 3  is OH or BH 3 \u2212 M + ; \n R 4  is hydrogen, hydroxy, alkyl, fluoromethyl, difluoromethyl, trifluoromethyl, hydroxymethyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 4  is optionally substituted with one or more, the same or different, R 20 ; \n R 5  is hydrogen, hydroxy, alkoxy, alkyl, alkenyl, alkynyl, ethynyl, fluoromethyl, difluoromethyl, trifluoromethyl, hydroxymethyl, allenyl, halogen, nitro, cyano, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 5  is optionally substituted with one or more, the same or different, R 20 ; \n R 8  is hydrogen, deuterium, alkyl, alkenyl, alkynyl, halogen, nitro, cyano, hydroxy, benzyloxy, amino, amido, mercapto, formyl, carboxy, carbamoyl, azido, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, aryl sulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 8  is optionally substituted with one or more, the same or different, R 20 ; \n R 9  is hydrogen, methyl, ethyl, tert-butyl, alkyl, higher alkyl, (C 6 -C 16 )alkyl, (C 6 -C 22 )alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, cycloalkyl, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 9  is optionally substituted with one or more, the same or different, R 20 ; \n R 10  is hydrogen, alkyl, branched alkyl, cycloalkyl, lipid methyl, ethyl, isopropyl, cyclopentyl, cyclohexyl, butyl, pentyl, hexyl, neopentyl, benzyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, aryl sulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 10  is optionally substituted with one or more, the same or different, R 20 ; \n R 11  is hydrogen, deuterium, alkyl, methyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 11  is optionally substituted with one or more, the same or different, R 20 ; \n R 12  is hydrogen, alkyl, aryl, phenyl, 1-naphthyl, 2-naphthyl, aromatic, heteroaromatic, 4-substituted phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, naphthyl, or heterocyclyl, wherein R 12  is optionally substituted with one or more, the same or different, R 20 ; \n R 13  is hydrogen, deuterium, alkyl, alkenyl, alkynyl, halogen, nitro, cyano, hydroxy, amino, amido, mercapto, formyl, carboxy, carbamoyl, lipid, azido, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, aryl sulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 13  is optionally substituted with one or more, the same or different, R 20 ; \n R 14  is hydrogen, deuterium, alkyl, alkenyl, alkynyl, halogen, nitro, cyano, hydroxy, amino, amido, mercapto, formyl, carboxy, carbamoyl, lipid, azido, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, aryl sulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 14  is optionally substituted with one or more, the same or different, R 20 ; \n R 15  is hydrogen, Lipid, \u2014(C\u2550O)Oalkyl, \u2014(C\u2550O)alkyl, \u2014(C\u2550O)NHalkyl, \u2014(C\u2550O)N-dialkyl, \u2014(C\u2550O)Salkyl, hydroxy, alkoxy, alkyl, higher alkyl, (C 6 -C 16 )alkyl, (C 6 -C 22 )alkyl, halogen, nitro, cyano, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, aryl sulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 15  is optionally substituted with one or more, the same or different, R 20 ; \n R 20  is deuterium, alkyl, alkenyl, alkynyl, halogen, nitro, cyano, hydroxy, amino, amido, mercapto, formyl, carboxy, carbamoyl, azido, alkoxy, alkylthio, alkylamino, (alkyl) 2 amino, alkylsulfinyl, alkyl sulfonyl, aryl sulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R 13  is optionally substituted with one or more, the same or different, R 21 ; and \n R 21  is halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl, ethyl sulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl; \n Lipid as described herein.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 91.0
- Lexical Diversity: 1.36364
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15204285', '14352176', '15311573', '14234127', '15694982']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6580375379838561
- 35 USC 102 Novelty (BERT): 0.546105468444323
- Combined Prediction Score: 0.6468443310299029
- Mean Citation Score: 419.61694400000016
- Max Citation Score: 435.66403
- Similarity Product: 260.7094300628847

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test