PATENT CLAIM ANALYSIS

Application Number: 16121481
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-06
Patent Classification: ["435", "005000"]

Abstract:
The invention provides diagnostic tests to distinguish between different pre-symptomatic neurodegenerative diseases.

Claim (Index 2):
A method of distinguishing between different neurodegenerative diseases in a biological fluid sample from a patient, comprising:\n (a) contacting the sample to a solid support, wherein the solid support comprises two or more locations, wherein each location is coated with a different capture agent specific for a target oligomer, and wherein the solid support is blocked with a blocking agent to form a bound sample; (b) incubating the bound sample; (c) contacting the bound sample with two or more labelled phages, wherein each labelled phage is specific for a single target oligomer to form labeled bound samples; (d) contacting the labeled bound samples with labeled detection agent to form a visualizable samples; and (e) comparing the quantity of the visualizable samples to quantities of controls to determine the quantity of each target oligomer; wherein an increase in toxic oligomeric A\u03b2 is indicative of the patient having early AD, wherein an increase in oligomeric A\u03b2 and tau aggregates is indicative of later stage AD, wherein an increase in oligomeric tau but not oligomeric A\u03b2 is indicative a tauopathy; wherein an increase in oligomeric a-syn is indicative of Parkinson's disease; and wherein an increase oligomeric A\u03b2 and a-syn is indicative of Dementia with Lewy Bodies (DLB).

Metadata:
- Claim Count in Document: 42.0
- Percentile: 97.0
- Lexical Diversity: 1.0
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15424444', '15479110', '14434742', '15114356', '13821172']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6295038175132052
- 35 USC 102 Novelty (BERT): 0.55705759419241
- Combined Prediction Score: 0.6222591951811256
- Mean Citation Score: 401.09184
- Max Citation Score: 474.53005999999993
- Similarity Product: 330.2567902649831

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test