PATENT CLAIM ANALYSIS

Application Number: 16161967
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["562", "567000"]

Abstract:
Disclosed are salts, such as nitrates, of acetyl-L-carnitine and propionyl-L-carnitine and methods of making the compounds.

Claim (Index 4):
A method of producing acetyl-L-carnitine nitrate comprising:\n producing acetyl-L-carnitine free base, comprising the steps of:\n adding L-carnitine and acetic acid into a reactor, wherein the L-carnitine is dissolved by acetic acid; \n adding acetic anhydride into the reactor after L-carnitine is dissolved, wherein the reaction between acetic anhydride and L-carnitine is allowed to react for 3-12 hours at 30\u00b0 C. to 80\u00b0 C.; \n distilling the contents of the reactor at reduced pressure, wherein acetic acid produced from the reaction of acetic anhydride and L-carnitine is distilled away before adding stirring in acetone into the reactor; \n crystallizing the contents of the reactor at a temperature of less than 5\u00b0 C., wherein the reactor is maintained at between 0\u00b0 C. and 5\u00b0 C. for at least two hours; and \n filtering the crystallized contents of the reactor before drying the contents to isolate acetyl-L-carnitine free base crystal; and \n producing acetyl-L-carnitine nitrate from the isolated acetyl-L-carnitine free base crystal, comprising the steps of:\n dissolving the isolated acetyl-L-carnitine free base crystal with acetic acid; \n reacting nitric acid with the dissolved acetyl-L-carnitine free base for 2-5 hours at between 30\u00b0 C. to 80\u00b0 C.; \n distilling the products of the reaction between nitric acid and acetyl-L-carnitine free base at reduced pressure, wherein the acetic acid and water produced from the reaction are distilled away before stirring acetone into the remaining products of the reaction; \n crystallizing the remaining products of the reaction at a temperature of less than 5\u00b0 C., wherein the remaining products are maintained at between 0\u00b0 C. and 5\u00b0 C. for at least two hours; and \n filtering the crystallized products of the reaction before drying to isolate acetyl-L-carnitine nitrate crystal.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.1875
- Patent Class: 562.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14570748', '15438516', '14136226', '15058406', '13127555']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7082106664437299
- 35 USC 102 Novelty (BERT): 0.5488898095934373
- Combined Prediction Score: 0.6922785807587006
- Mean Citation Score: 276.21439
- Max Citation Score: 403.36154
- Similarity Product: 313.94467220105173

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test