PATENT CLAIM ANALYSIS

Application Number: 16227132
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-06
Patent Classification: ["544", "283000"]

Abstract:
The present invention relates to quinazolinones and related compounds which are inhibitors of PARP14 and are useful, for example, in the treatment of cancer and inflammatory diseases.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein:\n W is CR W  or N; \n X is CR X  or N; \n Y is CR Y  or N; \n Z is CR Z  or N; \n wherein no more than two of W, X, Y, and Z are simultaneously N; \n Ring A is monocyclic or polycyclic C 3-14  cycloalkyl or Ring A is monocyclic or polycyclic 4-18 membered heterocycloalkyl, wherein Ring A is optionally substituted by 1, 2, 3, or 4 R A , and Ring A is attached to the -(L) m -moiety of Formula I through a non-aromatic ring when Ring A is polycyclic; \n L is (CR 5 R 6 ) t \u2014, \u2014(CR 5 R 6 ) p \u2014O\u2014(CR 5 R 6 ) q \u2014, \u2014(CR 5 R 6 ) p \u2014S\u2014(CR 5 R 6 ) q \u2014, \u2014(CR 5 R 6 ) p \u2014NR 3 \u2014(CR 5 R 6 ) q \u2014, \u2014(CR 5 R 6 ) p \u2014CO\u2014(CR 5 R 6 ) q \u2014, \u2014(CR 5 R 6 ) r \u2014C(O)O\u2014(CR 5 R 6 ) s \u2014, \u2014(CR 5 R 6 ) r \u2014CONR 3 \u2014(CR 5 R 6 ) s \u2014, \u2014(CR 5 R 6 ) p \u2014SO\u2014(CR 5 R 6 ) q \u2014, \u2014(CR 5 R 6 ) p \u2014SO 2 \u2014(CR 5 R 6 ) q \u2014, \u2014(CR 5 R 6 ) r \u2014SONR 3 \u2014(CR 5 R 6 ) s \u2014, or \u2014NR 3 CONR 4 \u2014; \n R 1  and R 2  are each, independently, selected from H and methyl; \n R 3  and R 4  are each, independently, selected from H and C 1-4  alkyl; \n R 5  and R 6  are each, independently, selected from H, halo, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, amino, C 1-4  alkylamino, and C 2-8  dialkylamino; \n each R A  is independently selected from halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, 4-10 membered heterocycloalkyl-C 1-4  alkyl, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , NR c1 R d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R d1 , C(\u2550NR e1 )R b1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , and S(O) 2 NR c1 R d1 ; \n wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl of R A  are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from Cy 1 , Cy 1 -C 1-4  alkyl, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , NR c1 R d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , and S(O) 2 NR c1 R d1 ;\n R W , R X , R Y , and R Z  are each, independently, selected from H, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, 4-10 membered heterocycloalkyl-C 1-4  alkyl, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , NR c2 R d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2 , C(\u2550NR e2 )R b2 , C(\u2550NR e2 )NR c2 R d2 , NR c2 C(\u2550NR e2 )NR c2 R d2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R b2 , NR c2 S(O) 2 NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 NR c2 R d2 ; wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl of R W , R X , R Y , or R Z  are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from Cy 2 , Cy 2 -C 1-4  alkyl, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , C(\u2550NR e2 )NR c2 R d2 , NR c2 C(\u2550NR e2 )NR c2 R d2 , NR c2 R d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R b2 , NR c2 S(O) 2 NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 NR c2 R d2 ; \n wherein when W is CR W , X is CR X , Y is CR Y , and Z is CR Z , then at least one of R W , R X , R Y , and R Z  is other than H; \n each Cy 1  is independently selected from C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 substituents independently selected from halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, 4-10 membered heterocycloalkyl-C 1-4  alkyl, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , NR c1 R d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , and S(O) 2 NR c1 R d1 ; \n each Cy 2  is independently selected from C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 substituents independently selected from halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, 4-10 membered heterocycloalkyl-C 1-4  alkyl, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , C(\u2550NR e2 )NR c2 R d2 , NR c2 C(\u2550NR e2 )NR c2 R d2 , NR c2 R d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2 , NR c2 S(O)R b2 , NR c2 S(O) 2 R b2 , NR c2 S(O) 2 NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 NR c2 R d2 ; \n each R a1 , R b1 , R c1 , R d1 , R a2 , R b2 , R c2 , and R d2  is independently selected from H, C 1-6  alkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl, wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl of R a1 , R b1 , R c1 , R d1 , R a2 , R b2 , R c2 , or R d2  is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from Cy 3 , Cy 3 -C 1-4  alkyl, halo, C 1-4  alkyl, C 1-4  haloalkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, CN, OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R d3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)NR c3 R d3  NR c3 C(O)OR a3 , C(\u2550NR e3 )NR c3 R d3  NR c3 C(\u2550NR e3 )NR c3 R d3  S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , NR c3 S(O) 2 R b3  NR c3 S(O) 2 NR c3 R d3 , and S(O) 2 NR c3 R d3 ; \n each Cy 3  is C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, or 4-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 substituents independently selected from halo, C 1-4  alkyl, C 1-4  haloalkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, CN, OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R d3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)NR c3 R d3  NR c3 C(O)OR a3 , C(\u2550NR e3 )NR c3 R d3  NR c3 C(\u2550NR e3 )NR c3 R d3  S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , NR c3 S(O) 2 R b3 , NR 3 S(O) 2 NR c3 R d3 , and S(O) 2 NR c3 R d3 ; \n R a3 , R b3 , R c3 , and R d3  are independently selected from H, C 1-6  alkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl, wherein said C 1-6  alkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, and C 1-6  haloalkoxy; \n or R c1  and R d1  together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from halo, C 1-4  alkyl, C 1-4  haloalkyl, CN, OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R d3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)NR c3 R d3  NR c3 C(O)OR a3 , C(\u2550NR e3 )NR c3 R d3 , NR c3 C(\u2550NR e3 )NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , NR c3 S(O) 2 R b3 , NR c3 S(O) 2 NR c3 R d3 , and S(O) 2 NR c3 R d3 ; \n or R c2  and R d2 , together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from halo, C 1-4  alkyl, C 1-4  haloalkyl, CN, OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R d3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)NR c3 R d3  NR c3 C(O)OR a3 , C(\u2550NR e3 )NR c3 R d3 , NR c3 C(\u2550NR e3 )NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , NR c3 S(O) 2 R b3 , NR c3 S(O) 2 NR c3 R d3  and S(O) 2 NR c3 R d3 ; \n each R e1 , R e2 , and R e3  is independently selected from H, C 1-4  alkyl, and CN; \n m is 0 or 1, \n n is 0, 1, or 2; \n p is 0, 1, or 2; \n q is 0, 1, or 2, wherein p+q is 0, 1, or 2; \n r is 0 or 1; \n s is 0 or 1, where r+s is 0 or 1; and \n t is 1, 2, or 3; \n wherein any aforementioned heteroaryl or heterocycloalkyl group comprises 1, 2, 3, or 4 ring-forming heteroatoms independently selected from O, N, and S; \n wherein one or more ring-forming C or N atoms of any aforementioned heterocycloalkyl group is optionally substituted by an oxo (\u2550O) group; \n wherein one or more ring-forming S atoms of any aforementioned heterocycloalkyl group is optionally substituted by one or two oxo (\u2550O) groups; \n wherein when W is CR W , X is CR X , Y is CR Y , and Z is CR Z  and when m is 1 or 2, then R X  and R Y  are not both methoxy; \n wherein the compound is other than:

Metadata:
- Claim Count in Document: 87.0
- Percentile: 98.0
- Lexical Diversity: 1.2
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15166380', '12270135', '14465910', '16308739', '15521202']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8169314194001163
- 35 USC 102 Novelty (BERT): 0.5207619848929023
- Combined Prediction Score: 0.7873144759493949
- Mean Citation Score: 326.669524
- Max Citation Score: 338.04504
- Similarity Product: 252.9029131027508

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test