PATENT CLAIM ANALYSIS

Application Number: 16037812
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["544", "400000"]

Abstract:
The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

Claim (Index 1):
A method of treating cancer comprising exposing the cancer to an effective amount of a procaspase activator compound that activates procaspase-3 upon contacting procaspase-3, wherein the procaspase activator compound is a compound Formula I: wherein\n R 1  is a substituted (aryl)methylene, or (aryl)methine wherein the methine carbon is optionally substituted with phenyl; \n n is 1, 2, 3, or 4; and \n each R 2  is alkyl; or two R 2  groups form an ortho-fused benzo group; and \n when R 1  is substituted (aryl)methylene, the (aryl)methylene substitution comprises one or more methoxy, nitro, sulfonamide, azidomethylene, halo, phenoxy, phenyl, methyl, ethyl, iso-propyl, trifluoromethyl, trifluoromethoxy, fused benzo, phenylsulfonylmethylene, benzyloxy, benzoyl, or a combination thereof; \n or a pharmaceutically acceptable salt or solvate thereof; \n thereby killing the cancer cell or inhibiting the cancer cell from proliferating.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 95.0
- Lexical Diversity: 2.0303
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13652164', '14417524', '15013667', '14321514', '13676650']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7133210219112278
- 35 USC 102 Novelty (BERT): 0.5495119039842148
- Combined Prediction Score: 0.6969401101185265
- Mean Citation Score: 319.372486
- Max Citation Score: 403.87213
- Similarity Product: 334.99732762934093

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test