PATENT CLAIM ANALYSIS

Application Number: 16114635
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["424", "093210"]

Abstract:
Embodiments of the present invention describe a method of changing the phenotype of monocytes and macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype. The method can comprises providing a composition comprising a recombinant adeno-associated virus (rAAV) vector comprising an exogenous gene encoding ApoA-I Milano or a fragment thereof, and administering the composition to a mammal in need thereof to change the phenotype of monocytes or macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype. By changing the phenotype of monocytes or macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype, atherosclerosis can be treated. The present invention also describes a method of monitoring macrophage phenotypic switching and a method of assessing the efficacy of the treatment of atherosclerosis.

Claim (Index 22):
The method of  claim 21 , comprising monitoring the monocyte or macrophage phenotypic switching in the human subject comprising:\n measuring the expression level of MCP-1, IL-6, TNF-a, Arg-1, Ym-1 and CD206 to monitor monocyte or macrophage phenotypic switching in a mammal in need thereof; and determining the presence of a phenotypic switch from a proinflammatory M1 macrophage to an anti-inflammatory M2 macrophage when MCP-1, IL-6 and/or TNF-a is down-regulated, and/or Arg-1, Ym-1 and/or CD206 is up-regulated, or determining the absence of a phenotypic switch from the proinflammatory M1 macrophage to the anti-inflammatory M2 macrophage when MCP-1, IL-6 and/or TNF-a is not down-regulated, and/or Arg-1, Ym-1 and/or CD206 is not up-regulated, or determining the presence of a phenotypic switch from an anti-inflammatory M2 macrophage to a proinflammatory M1 macrophage when MCP-1, IL-6 and/or TNF is up-regulated, and/or Arg-1 and/or CD206 is down-regulated, or determining the presence of a phenotypic switch from a proinflammatory M1 macrophage to an anti-inflammatory M2 macrophage when MCP-1, IL-6 and/or TNF-a is down-regulated, and/or when, Arg-1, Ym-1 and/or CD206 is not up-regulated.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 96.0
- Lexical Diversity: 2.18033
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10599692', '15458560', '14114471', '15036249', '15317673']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.691707491233977
- 35 USC 102 Novelty (BERT): 0.5284508580149645
- Combined Prediction Score: 0.6753818279120758
- Mean Citation Score: 262.89997800000003
- Max Citation Score: 347.70877
- Similarity Product: 235.44484210992755

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test