PATENT CLAIM ANALYSIS

Application Number: 15983209
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["506", "009000"]

Abstract:
The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use. In some embodiments, a reference scorecard can be compared with the test stem cell line scorecard to accurately predict the utility and/or identify specific characteristics of the stem cell line, e.g., to determine its suitability for downstream applications, e.g., therapeutic use, drug screening, toxicity assays, differentiation into a desired cell lineage, etc.

Claim (Index 6):
The array of  claim 1 , wherein the level of expression of the set of at least 20 early developmental genes is measured and compared with a reference gene expression level for the same set of early developmental genes; and\n a pluripotent stem cell line is selected on the basis of there being no statistically significant difference in the level of gene expression of the measured early developmental genes as compared to the reference gene expression level for the early developmental genes; or on the basis of having a statistically significant difference in the expression level in at least one desired early developmental gene as compared to the reference expression level of the early developmental genes.

Metadata:
- Claim Count in Document: 30.0
- Percentile: 93.0
- Lexical Diversity: 2.01235
- Patent Class: 506.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14936774', '13114102', '12664763', '14439037', '13998974']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6047214951184475
- 35 USC 102 Novelty (BERT): 0.5362650812354629
- Combined Prediction Score: 0.5978758537301491
- Mean Citation Score: 351.49161200000015
- Max Citation Score: 374.56046
- Similarity Product: 247.05370159771203

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test