PATENT CLAIM ANALYSIS

Application Number: 16001770
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "210180"]

Abstract:
The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Claim (Index 1):
A compound of formula II: wherein:\n (1) A is \n B is B 1  and R 5  is R 5a ; or (2) A is B is B 2  and R 5  is R 5b ; or (3) A is B is B 3  and R 5  is R 5a ; or (4) A is B is B 4  and R 5  is R 5a ; or (5) A is B is B 1  and R 5  is R 5a ; or (6) A is B is B 5  and R 5  is R 5a ; or (7) A is B is B 3  and R 5  is R 5a ; B is a 5-membered heteroaryl comprising 2 or 3 nitrogen atoms in the ring that is optionally substituted with one or more groups independently selected from halogen, (C 1 -C 6 )alkyl, \u2014O(C 1 -C 6 )alkyl, \u2014CN, and NR 6 2  (C 3 -C 7 )cycloalkyl; R 1  is a phenyl or 5-membered heteroaryl, wherein R 1  is optionally substituted with one or more groups independently selected from halogen, \u2014CN, (C 1 -C 6 )alkyl and (C 1 -C 6 )haloalkyl; R 2  is halogen, (C 1 -C 6 )alkyl or CN, wherein any (C 1 -C 6 )alkyl of R 2  is optionally substituted with one or more groups independently selected from halogen, \u2014OH and \u2014O(C 1 -C 6 )alkyl; each R 3a  is independently selected from H, halogen and (C 1 -C 6 )alkyl; one R 3b  group is halogen, \u2014CN, or (C 1 -C 6 )alkyl and the remaining R 3b  groups are independently selected from H, (C 1 -C 6 )alkyl and (C 1 -C 6 )haloalkyl;\n one R 3b \u2032 group is halogen, (C 1 -C 6 )alkyl, \u2014CN, or (C 1 -C 6 )haloalkyl and the remaining R 3b \u2032 groups are independently selected from H, (C 1 -C 6 )alkyl and (C 1 -C 6 )haloalkyl; \n two R 3c  groups attached to different non-adjacent carbon atoms or adjacent carbon atoms are combined to form a (C 1 -C 4 )alkyl linker or a (C 1 -C 2 )alkyl-O-(C 1 -C 2 )alkyl linker, wherein the (C 1 -C 4 )alkyl linker or (C 1 -C 2 )alkyl-O-(C 1 -C 2 )alkyl linker is optionally substituted with one or more groups independently selected from halogen and (C 1 -C 6 )alkyl, and the remaining R 3c  groups are independently selected from H, halogen and (C 1 -C 6 )alkyl; each R 3d  group is independently selected from H, halogen, (C 1 -C 6 )alkyl, and \u2014CN, wherein any (C 1 -C 6 )alkyl of R 3d  is optionally substituted with one or more groups independently selected from halogen, \u2014OH and \u2014O(C 1 -C 6 )alkyl; one R 3e  group is halogen, \u2014CN or (C 1 -C 6 )alkyl and the remaining R 3e  groups are independently selected from H, (C 1 -C 6 )alkyl and (C 1 -C 6 )haloalkyl;\n two R 3f  groups attached to the same carbon atom are combined to form a (C 2 -C 4 )alkyl linker, wherein the (C 2 -C 4 )alkyl linker is optionally substituted with one or more groups independently selected from halogen and (C 1 -C 6 )alkyl, and the remaining R 3f  groups are independently selected from H, halogen and (C 1 -C 6 )alkyl; \n R 4  is H, (C 1 -C 6 )alkyl or (C 1 -C 6 )haloalkyl; R 5  is R 5a  or R 51 ); R 5 a is a phenyl, 5-membered heteroaryl, 6-membered heteroaryl, 4, 5, 6 or 7-membered heterocycle or (C 3 -C 8 )cycloalkyl, wherein any phenyl, 5-membered heteroaryl, 6-membered heteroaryl, 4, 5, 6 or 7-membered heterocycle or (C 3 -C 8 )cycloalkyl of R 5a  is optionally substituted with one or more groups independently selected from halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, \u2014CN, (C 3 -C 7 )cycloalkyl, \u2014O(C 1 -C 6 )alkyl, \u2014O(C 1 -C 6 )alkyl-O(C 1 -C 6 )alkyl, \u2014O(C 1 -C 6 )haloalkyl, \u2014S(C 1 -C 6 )alkyl, \u2014S(C 1 -C 6 )haloalkyl, oxo and \u2014O\u2014(C 1 -C2)alkyl-O- optionally substituted with one or more halogen, which \u2014O\u2014(C 1 -C 2 )alkyl-O- group is bonded to two adjacent carbon atoms of any phenyl, 5-membered heteroaryl, 6-membered heteroaryl, 4, 5, 6 or 7-membered heterocycle or (C 3 -C 8 )cycloalkyl of R 5a ; R 5b  is a phenyl, 5-membered heteroaryl, 6-membered heteroaryl or 4, 5, 6, 7 or 8-membered heterocycle, wherein any phenyl, 5-membered heteroaryl, 6-membered heteroaryl or 4, 6, 7 or 8-membered heterocycle of R 5b  is optionally substituted with one or more groups independently selected from halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, \u2014CN, (C 3 -C 7 )cycloalkyl optionally substituted with one or more halogen, \u2014O(C 1 -C 6 )alkyl, \u2014O(C 1 -C 6 )haloalkyl, \u2014OH, \u2014S(C 1 -C 6 )alkyl, \u2014S(C 1 -C 6 )haloalkyl, and NR 6 2 , and wherein any 5-membered heterocycle of R 5b  is substituted with one or more groups independently selected from halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, \u2014CN, (C 3 -C 7 )cycloalkyl, \u2014O(C 1 -C 6 )alkyl, \u2014O(C 1 -C 6 )haloalkyl, \u2014S(C 1 -C 6 )alkyl and \u2014S(C 1 -C 6 )haloalkyl; and each R 6  is independently H or (C 1 -C 6 )alkyl; or pharmaceutically acceptable a salt thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 94.0
- Lexical Diversity: 1.53488
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15885390', '15380836', '14527328', '15905524', '15287911']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7954871775192738
- 35 USC 102 Novelty (BERT): 0.5347621714233842
- Combined Prediction Score: 0.7694146769096848
- Mean Citation Score: 372.047722
- Max Citation Score: 380.59314
- Similarity Product: 227.38778293928863

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test