PATENT CLAIM ANALYSIS

Application Number: 16204642
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-06
Patent Classification: ["435", "006120"]

Abstract:
The invention provides methods for determining the MSI status of a patient by liquid biopsy with sample preparation using hybrid capture and non-unique barcodes. In certain aspects, the invention provides a method of detecting microsatellite instability (MSI). The method includes obtaining cell-free DNA (cfDNA) from a sample of blood or plasma from a patient and sequencing portions of the cfDNA to obtain sequences of a plurality of tracts of nucleotide repeats in the cfDNA. A report is provided describing an MSI status in the patient when a distribution of lengths of the plurality of tracts has peaks that deviate significantly from peaks in a reference distribution.

Claim (Index 6):
The method of  claim 5 , wherein the use of the non-unique barcodes to identify groups of sequence reads that originated from a unique cfDNA fragment which allows for the lengths of the plurality of tracts to be determined correctly by correcting for errors introduced by sequencing artifacts or polymerase slippage during the amplifying step.

Metadata:
- Claim Count in Document: 80.0
- Percentile: 98.0
- Lexical Diversity: 1.66667
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13860422', '14852664', '11576597', '10505725', '11612567']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6641738921911734
- 35 USC 102 Novelty (BERT): 0.5240352293398451
- Combined Prediction Score: 0.6501600259060406
- Mean Citation Score: 295.75576999999987
- Max Citation Score: 323.45447
- Similarity Product: 187.9444660748852

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test