PATENT CLAIM ANALYSIS

Application Number: 15942321
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "210020"]

Abstract:
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Claim (Index 5):
The compound of  claim 4 , wherein R 1  is: wherein R 6 , R 7 , and R 8  are each independently selected from the group consisting of:\n i. branched or linear C 1-6  alkyl, C 1-6  alkenyl, C 1-6  alkenylene, and C 3-9  cycloalkyl, wherein said alkyl, alkenyl, alkenylene, and cycloalkyl are optionally substituted with one to four substituents independently selected from the group consisting of hydroxyl, halogen, \u2014CHF 2 , \u2014CF 3 , amino, di(C 1-6  alkyl)amino, mono(C 1-6  alkyl)amino, cyano, C 3-7  cycloalkyl, C 1-6  alkoxy, \u2014S(O)R\u2032, \u2014SO 2 R\u2032, \u2014SO 2 NR\u2032R\u2033, \u2014C(O)NR\u2032R\u2033, and \u2014NR\u2032C(O)R\u2033, wherein R\u2032 and R\u2033 are independently H or C 1-6  alkyl; \n ii. NR a R b \u2014C(O)\u2014, wherein, R a  and R b  are each independently hydrogen or C 1-6  alkyl, wherein said alkyl can optionally be substituted with hydroxyl, halogen, \u2014CHF 2 , or \u2014CF 3 ; \n iii. C 1-6  alkoxy; \n iv. halogen; \n v. cyano; \n vi. hydroxyl; \n vii. amino; \n viii. di(C 1-6  alkyl)amino; \n ix. mono(C 1-6  alkyl)amino; \n x. \u2014NR c C(O)R d , wherein R c  and R d  are independently H or C 1-6  alkyl; \n xi. \u2014CF 3 ; \n xii. \u2014CHF 2 ; \n xiii. \u2014SO 2 R\u2032, wherein R\u2032 is H or C 1-6  alkyl; \n xiv. \u2014SO 2 NR\u2032R\u2033, wherein R\u2032 and R\u2033 are independently H or C 1-6  alkyl; \n xv. \u2014C(O)NR c R d ; wherein R c  and R d  are independently H or C 1-6  alkyl; \n xvi. \u2014C(O)OR e ; wherein R e  is H, C 1-6  alkyl, or CH 2 -aryl; \n xvii. C 3-5  heterocyclyl, C 6-10  aryl, \u2014(C 1-6  alkyl)(C 6-10  aryl), or C 2-9  heteroaryl, wherein said heterocyclyl, aryl, or heteroaryl can be optionally substituted with C 1-6  alkyl, C 6-10  aryl, or \u2014C(O)OR e ; wherein R e  is H, C 1-6  alkyl, or CH 2 -aryl; \n xviii. \u2014O\u2014(C 2-9  heteroaryl); \n xix. \u2014NR'S(O) k\u2032 R\u2033, wherein k\u2032 is 1 or 2 and R\u2032 and R\u2033 are independently H or C 1-6  alkyl; \n wherein the C 6-10  aryl, C 2-9  heteroaryl or C 2-9  heterocyclyl of R 1  together with two of R 6 , R 7 , and R 8  can form a bicyclic; and \n wherein a carbon embedded in said aryl, heteroaryl or heterocyclyl taken together with an oxygen to which it is bound can form a carbonyl.

Metadata:
- Claim Count in Document: 140.0
- Percentile: 90.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12530648', '13102720', '15281923', '13266976', '15852639']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7844712151315855
- 35 USC 102 Novelty (BERT): 0.5160074438377069
- Combined Prediction Score: 0.7576248380021976
- Mean Citation Score: 269.39763800000003
- Max Citation Score: 276.27457000000004
- Similarity Product: 189.5860713657892

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test