PATENT CLAIM ANALYSIS

Application Number: 15575778
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2018-10
Patent Classification: ["544", "293000"]

Abstract:
The present invention relates to an improved process for the preparation of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1:2) represented by the following structural formula:

Claim (Index 12):
A process for the preparation of crystalline form-M of 4-[(3-Chloro-4-fluorophenyl)amino]-6-amino-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline dihydrochloride compound of formula-8a, comprising of;\n a) Treating the (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl) oxy)quinazolin-4-amine compound of formula-7 with iron in presence of acetic acid, b) adding ethylacetate and stirring the reaction mixture, c) basifying the reaction mixture with aqueous sodium carbonate, d) filtering the reaction mixture, e) separating both the aqueous and organic layers, f) treating the organic layer with isopropanolic-HCl at 0-5\u00b0 C., g) filtering the precipitated solid provides crystalline form-M of 4-[(3-Chloro-4-fluorophenyl)amino]-6-amino-7-((S)tetrahydrofuran-3-yloxy)-quinazoline dihydrochloride compound of formula-8a.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 97.0
- Lexical Diversity: 1.46154
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15516382', '15565996', '15553843', '13138429', '11997719']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5261060633502918
- 35 USC 102 Novelty (BERT): 0.5246219309360992
- Combined Prediction Score: 0.5259576501088725
- Mean Citation Score: 289.474582
- Max Citation Score: 317.6971
- Similarity Product: 234.680434174192

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test