PATENT CLAIM ANALYSIS

Application Number: 15563888
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "256000"]

Abstract:
A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis, eczema, itch or psoriasis, is disclosed. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

Claim (Index 48):
The compound of  claim 1 , or the pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:\n 4,6-dimethoxy-N-[5-methyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-iodo-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(4-chlorophenyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(4-chlorophenyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-diethoxypyrimidine-5-carboxamide; N-[5-ethyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-cyano-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-diethoxypyrimidine-5-carboxamide; N-[5-(6-fluoropyridin-3-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-(4,5-dimethyl-1,3-thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{4-(trifluoromethyl)-5-[(trimethylsilyl)ethynyl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[5-ethynyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(3-hydroxyprop-1-yn-1-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(3-hydroxypropyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(cyclopropylethynyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(3-methoxyprop-1-yn-1-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(3-methoxypropyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[(1Z)-3-methoxyprop-1-en-1-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[(1E)-3-methoxyprop-1-en-1-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[5-(3-hydroxy-3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(3-hydroxy-3-methylbutyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; ethyl 2-{[(4,6-dimethoxypyrimidin-5-yl)carbonyl]amino}-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate; N-[5-(2-hydroxyethyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[6-(morpholin-4-yl)pyridin-3-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[5-(3-cyanopyridin-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(2-cyano-3-fluorophenyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-(5-ethyl-4-phenyl-1,3-thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(5-fluoropyridin-3-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(pyrazin-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[5-(morpholin-4-yl)pyrazin-2-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{4-(trifluoromethyl)-5-[6-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[5-(6-cyanopyridin-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(morpholin-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-{5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-propyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(2,2-dimethyl-1,3-dioxolan-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[2-(morpholin-4-yl)pyrimidin-5-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[5-cyclopropyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(3,6-dihydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(tetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(3-cyanophenyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(4-cyanophenyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(2-cyanopyridin-3-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(4-cyano-2-methoxyphenyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(6-cyano-1H-indol-3-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(pyridin-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(5-chloropyridin-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-formyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[(4-methoxypiperidin-1-yl)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(pyrrolidin-1-ylmethyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(morpholin-4-ylmethyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-{5-[(cyclopentylamino)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-{[(2-methylpropyl)amino]methyl}-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-{5-[(4-fluoropiperidin-1-yl)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-{[methyl(2-methylpropyl)amino]methyl}-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-{[tert-butyl(methyl)amino]methyl}-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[(tert-butylamino)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-{[(3 S)-3-fluoropyrrolidin-1-yl]methyl}-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-{[(3S)-3-methoxypyrrolidin-1-yl]methyl}-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-{[(3R)-3-methoxypyrrolidin-1-yl]methyl}-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(2-oxa-7-azaspiro[3.5]non-7-ylmethyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(2-oxa-6-azaspiro[3.5]non-6-ylmethyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-chloro-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(2-methylpyridin-3-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[5-(2-cyanopyridin-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(1,3-dimethyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; {[(4,6-dimethoxypyrimidin-5-yl)carbonyl][5-(1,3-dimethyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}methyl dihydrogen phosphate; N-[5-ethyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-2-methylpyrimidine-5-carboxamide; 4-ethoxy-N-[5-ethyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-6-methoxypyrimidine-5-carboxamide; 4,6-diethoxy-N-[5-ethyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-(5-(pyridin-4-yloxy)-4-(trifluoromethyl)thiazol-2-yl)pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; ([(4,6-dimethoxypyrimidin-5-yl)carbonyl]{4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}amino)methyl dihydrogen phosphate; ethyl 2-{[(4,6-dimethoxypyrimidin-5-yl)carbonyl]amino}-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxylate; N-{5-formyl-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-(morpholin-4-ylmethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-(pyrrolidin-1-ylmethy)-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-{5-(dimethylcarbamoyl)-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4-hydroxy-6-methoxypyrimidine-5-carboxamide; N-{5-(hydroxymethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; ([(4,6-dimethoxypyrimidin-5-yl)carbonyl]{5-(hydroxymethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}amino)methyl dihydrogen phosphate; N-{5-(1-hydroxyethyl)-4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[(1R*)-1-hydroxyethyl]-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[(1S*)-1-hydroxyethyl]-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-(2-hydroxypropan-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-(methoxymethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-{5-acetyl-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[(1E)-N-hydroxyethanimidoyl]-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[(1E)-N-methoxyethanimidoyl]-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-(2-methyl-1,3-dioxolan-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[4-(5-fluoropyridin-2-yl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{4-[5-(trifluoromethoxy)pyridin-2-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-{4-[5-(difluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-{5-(3-hydroxypropyl)-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-cyano-4-[5-(trifluoromethyl)pyridin-2-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-(4-cyclopentyl-1,3-thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; N-[4-(4,4-difluorocyclohexyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-(4-tert-butyl-5-fluoro-1,3-thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; N-(4-cyclobutyl-5-fluoro-1,3-thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; N-(5-cyano-4-cyclobutyl-1,3-thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; N-{4-[(E)-2-cyclopropylethenyl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{4-[(1E)-3,3-dimethylbut-1-en-1-yl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-[4-(2-cyclopropylethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-{4-[(E)-2-(4-fluorophenyl)ethenyl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{4-[2-(4-fluorophenyl)ethyl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-[4-(4-fluoro-2-methoxyphenyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(p-tolylsulfonyl)-4-[5-(trifluoromethyl)-2-pyridyl]-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(p-tolylsulfonyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-benzylsulfonyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide; N-(5-(benzylsulfinyl)-4-(trifluoromethyl)thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-methylsulfinyl-4-[5-(trifluoromethyl)-2-pyridyl]-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-methylsulfonyl-4-[5-(trifluoromethyl)-2-pyridyl]-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-phenylsulfanyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(2-hydroxypropan-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(4-hydroxytetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(4-fluorotetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(1-hydroxycyclobutyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[hydroxy(phenyl)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-benzoyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(1-hydroxy-1-phenylethyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(1-hydroxy-2,2-dimethylpropyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(2,2-dimethylpropanoyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[(E)-(methoxyimino)(phenyl)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-{5-[(E)-(hydroxyimino)(phenyl)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(pyridin-2-ylcarbonyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-{5-[(E)-(hydroxyimino)(pyridin-2-yl)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[1-hydroxy-1-(pyridin-2-yl)ethyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[(5-fluoropyridin-2-yl)(hydroxy)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[(5-fluoropyridin-2-yl)carbonyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[(E)-(5-fluoropyridin-2-yl)(hydroxyimino)methyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-acetyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[(1E)-N-hydroxyethanimidoyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[(1E)-N-methoxyethanimidoyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[(1Z)\u2014N-methoxyethanimidoyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(2-methyl-1,3-dioxolan-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(1,3-dioxolan-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(1,3-dioxan-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(1,3-oxazol-5-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(4-methyl-1,3-oxazol-5-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(1-ethyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(4,5-dihydrofuran-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(tetrahydrofuran-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-(5-(4,5-dihydrofuran-3-yl)-4-(trifluoromethyl)thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(tetrahydrofuran-3-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(3,4-dihydro-2H-pyran-5-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(tetrahydro-2H-pyran-3-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[(3S*)-tetrahydro-2H-pyran-3-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[(3R)-tetrahydro-2H-pyran-3-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-{5-[2-(1-cyanocyclopropyl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[2-(cyanomethyl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(6-fluoropyridin-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[6-(3-cyanooxetan-3-yl)pyridin-2-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[6-(cyanomethyl)pyridin-2-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[5-(propan-2-yloxy)pyridin-3-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-{5-[5-(1-cyanocyclopropyl)pyridin-2-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[5-(2-cyanopropan-2-yl)pyridin-2-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(2-cyanophenyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4-methoxy-6-(methylsulfanyl)pyrimidine-5-carboxamide; N-[5-(2-cyanophenyl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4-(ethylsulfanyl)-6-methoxypyrimidine-5-carboxamide; 2-cyano-N-[5-iodo-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4-methoxy-6-(trifluoromethyl)pyrimidine-5-carboxamide; N-[5-(2-cyanopyrimidin-5-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[4,5-bis(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(4-cyanocyclohex-1-en-1-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 310 4,6-dimethoxy-N-{5-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{4-(trifluoromethyl)-5-[2-(trifluoromethyl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(quinolin-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(1-cyclopropyl-H-pyrazol-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(1,2-oxazol-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[3-(propan-2-yl)-4,5-dihydro-1,2-oxazol-5-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[3-(propan-2-yl)-1,2-oxazol-5-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(1,2-oxazol-3-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-{5-[4-(2-cyanopropan-2-yl)phenyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[1-(propan-2-yl)-1H-pyrazol-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-{5-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(1-ethyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-{4-[2-(4-fluorophenoxy)ethyl]-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{4-[(2-methylphenoxy)methyl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[1-(propan-2-yl)-1H-pyrazol-5-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[1-methyl-3-(propan-2-yl)-1H-pyrazol-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[2-(morpholin-4-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-(2-methoxypyrimidin-5-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; N-[5-(5-cyano-6-methoxypyridin-3-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[2-(morpholin-4-yl)pyridin-3-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[5-(furo[3,2-b]pyridin-2-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[1-(cyclopropylmethyl)-1H-pyrazol-5-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-(4-tert-butyl-5-cyano-1,3-thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; N-[4-cyclopropyl-5-(4-fluorobenzyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[4-(2,2-dimethylpropyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-(5-bromo-4-tert-butyl-1,3-thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; ethyl 4-tert-butyl-2-{[(4,6-dimethoxypyrimidin-5-yl)carbonyl]amino}-1,3-thiazole-5-carboxylate; 365 4,6-dimethoxy-N-{5-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[3-(morpholin-4-ylsulfonyl)phenyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{4-(trifluoromethyl)-5-[5-(trifluoromethyl)pyridin-3-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; 4,6-dimethoxy-N-[5-{3-[(2-methoxyethyl)(methyl)sulfamoyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-yl]pyrimidine-5-carboxamide; 4,6-dimethoxy-N-{5-[4-(morpholin-4-ylmethyl)phenyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[5-(2,1,3-benzoxadiazol-5-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-[5-{3-[(dimethylsulfamoyl)amino]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; 4,6-dimethoxy-N-{4-(trifluoromethyl)-5-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-thiazol-2-yl}pyrimidine-5-carboxamide; N-[5-(2-cyclopropylpyrimidin-5-yl)-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide; N-{5-[5-cyano-6-(morpholin-4-yl)pyridin-3-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxypyrimidine-5-carboxamide; N-(5-(6-cyano-5-(oxetan-3-yl-methoxy)pyridine-3-yl)-4-(trifluoromethyl)thiazol-2-yl)-4,6-dimethoxypyrimidine-5-carboxamide; and 4,6-dimethoxy-N-(5-(methoxymethyl)-4-(trifluoromethyl)thiazol-2-yl)pyrimidine-5-carboxamide.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.37209
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13428259', '12636213', '15094687', '13503231', '14138941']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8269243128353895
- 35 USC 102 Novelty (BERT): 0.5344592919189052
- Combined Prediction Score: 0.797677810743741
- Mean Citation Score: 349.872878
- Max Citation Score: 364.68573
- Similarity Product: 314.5003201376564

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test