PATENT CLAIM ANALYSIS

Application Number: 16095315
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["424", "489000"]

Abstract:
In the present invention, the whole preparation process of the sustained-release microparticles is at normal or low temperature, which is highly advantageous for the preparation of a polymer-based composition from a high-temperature-sensitive drug, particularly a protein, nucleic acid and peptide drug, and the bioactivity of the active substance can be maintained to the greatest extent throughout the process compared to the disclosed technology; at the same time, the prepared sustained-release microparticles have an excellent sustained-release effect close to zero order, and the drug concentration is stabilized during the release, which overcomes the defects that the microparticles obtained by the conventional S/O/W process of pre-preparing the drug microparticles have no drug release in the earlier stage and a rapid release of the drug in the later stage; and in addition, the sustained-release microparticles have higher drug loading rate and drug encapsulation rate.

Claim (Index 8):
The preparation method of sustained-release microparticles according to  claim 1 , characterized in that the method further comprises the step of adding an additive which is added during the process of preparing the solid dispersion in step 1) or during the process of preparing the solid dispersion emulsion in step 2); and the additive is 0.01-10% of the sum of the mass of the water-soluble drug and the poorly water-soluble polymer.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 97.0
- Lexical Diversity: 1.88889
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14898415', '15444712', '13995727', '13472219', '12221096']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.753520063088343
- 35 USC 102 Novelty (BERT): 0.5062811917019233
- Combined Prediction Score: 0.728796175949701
- Mean Citation Score: 254.79315000000005
- Max Citation Score: 275.04373
- Similarity Product: 205.4753331461156

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test