PATENT CLAIM ANALYSIS

Application Number: 15990711
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["546", "113000"]

Abstract:
The present invention relates to a process for the preparation substantially pure propane-1-sulfonicacid-{3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide or Vemurafenib of Formula (I). The present invention further relates to a process for the preparation substantially pure propane-1-sulfonic acid-{3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3 -b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide trifluoro methane sulfonic acid salt or Vemurafenib triflate of Formula (VII)

Claim (Index 1):
A process for the preparation of substantially pure Vemurafenib Formula (1) comprising the steps of\u2014 a) reacting 2,6-difluoro-3-(((propan-1-yl)sulphony)amino)benzoic acid (U) with a halogenating agent in the ratio between 2-10 v/w times, to provide a compound of Formula (III); b) reacting compound. of Formula (III) with 5-bromo-1H-pyrrolo[2,3-b]pyridine (IV) to provide a compound of Formula (V); c) reacting compound of Formula (V) with 4-Chlorophenylboronic acid (VI) to form Vemurafenib(I); d) optionally purifying Venzurafenib using alkaline solution; e) reacting Vemurafenib obtained in step (C) with trifluoro methane sulfonic acid salt to provide Venturafenib trifluoromethane sultbnic acid salt(VII); treating compound of Formula (VII) with an alkaline solution to obtain substantially pure Vemurafenib (I) having a purity of greater than 99.5%; and/or g) optionally, repeating the steps d) and e) to get the desired purity.

Metadata:
- Claim Count in Document: 6.0
- Percentile: 93.0
- Lexical Diversity: 1.82222
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15527721', '13816376', '14373163', '16068575', '15366229']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7287781423187003
- 35 USC 102 Novelty (BERT): 0.52347264679871
- Combined Prediction Score: 0.7082475927667014
- Mean Citation Score: 257.726786
- Max Citation Score: 326.7036700000001
- Similarity Product: 253.0525405396837

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test