PATENT CLAIM ANALYSIS

Application Number: 16306083
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["514", "169000"]

Abstract:
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoid compounds that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt thereof: wherein; R 1  is isopropenyl or isopropyl; X is a phenyl or heteroaryl ring substituted with A, wherein A is at least one member selected from \u2014H, -halo, -hydroxyl, \u2014C 1-6  alkyl, \u2014C 1-6  alkoxy, and \u2014COOR 2 ; R 2  is \u2014H, \u2014C 1-6  alkyl, -alkylsubstituted C 1-6  alkyl or -arylsubstituted C 1-6  alkyl; Y is selected from \u2014COOR 2 , \u2014C(O)NR 2 SO 2 R 3 , \u2014C(O)NHSO 2 NR 2 R 2 , \u2014NR 2 SO 2 R 2 , \u2014SO 2 NR 2 R 2 , \u2014C 3-6  cycloalkyl-COOR 2 , \u2014C 2-6  alkenyl-COOR 2 , \u2014C 2-6  alkynyl-COOR 2 , \u2014C 1-6  alkyl-COOR 2 , \u2014NHC(O)(CH 2 ) n \u2014COOR 2 , \u2014SO 2 NR 2 C(O)R 2 , -tetrazole, and \u2014CONHOH, wherein n=1-6; R 3  is \u2014C 1-6  alkyl or -alkylsubstituted C 1-6  alkyl; W is selected from \u2014CH 2 OR 2 , \u2014COOR 2 , \u2014NR 4 R 5 , \u2014CONR 26 R 27 , \u2014CH 2 NR 26 R 27 , \u2014NR 4 COR 6 , \u2014NR 4 C(O)NR 4 R 5 , and \u2014NR 4 COOR 6 ; R 4  is selected from \u2014H, \u2014C 1-6  alkyl, \u2014C 1-6  alkyl-C(OR 3 ) 2 \u2014C 3-6  cycloalkyl, \u2014C 1-6  substituted alkyl, \u2014C 1-6  alkyl-C 3-6  cycloalkyl, \u2014C 1-6  alkyl-Q 1 , \u2014C 1-6  alkyl-C 3-6  cycloalkyl-Q 1 , aryl, heteroaryl, substituted heteroaryl, \u2014COR 6 , \u2014COCOR 6 , \u2014SO 2 R 7 , \u2014SO 2 NR 2 R 2 , wherein Q 1  is selected from C 3-10  carbocycle, substituted C 3-10  carbocycle, C 3-10  heterocycle, substituted C 3-10  heterocycle, aryl, heteroaryl, substituted heteroaryl, halogen, \u2014CF 3 , \u2014OR 2 , \u2014COOR 2 , \u2014NR 8 R 9 , \u2014CONR 10 R 11  and \u2014SO 2 R 7 ; R 5  is selected from \u2014H, \u2014C 1-6  alkyl, \u2014C 3-6  cycloalkyl, \u2014C 1-6  alkylsubstituted alkyl, \u2014C 1-6  alkyl-NR 8 R 9 , \u2014COR 6 , \u2014COCOR 6 , \u2014SO 2 R 7  and \u2014SO 2 NR 2 R 2 ; with the proviso that only one of R 4  or R 5  can be selected from \u2014COR 6 , \u2014COCOR 6 , \u2014SO 2 R 7  and \u2014SO 2 NR 2 R 2 ; R 6  is selected from \u2014H, \u2014C 1-6  alkyl, \u2014C 1-6  alkyl-substitutedalkyl, \u2014C 3-6  cycloalkyl, \u2014C 3-6  substitutedcycloalkyl-Q 2 , \u2014C 1-6  alkyl-Q 2 , \u2014C 1-6  alkyl-substitutedalkyl-Q 2 , \u2014C 3-6  cycloalkyl-Q 2 , aryl-Q 2 , \u2014NR 13 R 14 , and \u2014OR 15 ; wherein Q 2  is selected from C 3-10  carbocycle, substituted C 3-10  carbocycle, C 3-10  heterocycle, substituted C 3-10  heterocycle, aryl, heteroaryl, substituted heteroaryl, \u2014OR 2 , \u2014COOR 2 , \u2014NR 8 R 9 , SO 2 R 7 , \u2014CONHSO 2 R 3 , and \u2014CONHSO 2 NR 2 R 2 ; R 7  is selected from \u2014C 1-6  alkyl, \u2014C 1-6  substituted alkyl, \u2014C 3-6  cycloalkyl, aryl, and heteroaryl; R 8  and R 9  are independently selected from \u2014H, \u2014C 1-6  alkyl, \u2014C 1-6  substituted alkyl, aryl, heteroaryl, substituted aryl, substituted heteroaryl, \u2014C 1-6  alkyl-Q 2 , and \u2014COOR 3 , or R 8  and R 9  are taken together with the adjacent N to form a cycle selected from: V is selected from \u2014CR 24 R 25 , \u2014SO 2 , \u2014O and \u2014NR 12 ; M is selected from \u2014CHR 24 R 25 , \u2014NR 26 R 27 , \u2014SO 2 R 7 , \u2014SO 2 NR 3 R 3  and \u2014OH; with the proviso that only one of R 8  or R 9  can be \u2014COOR 3 ; R 10  and R 11  are independently selected from \u2014H, \u2014C 1-6  alkyl, \u2014C 1-6  substituted alkyl and \u2014C 3-6  cycloalkyl, or R 10  and R 11  are taken together with the adjacent N to form a cycle such as R 12  is selected from \u2014C 1-6  alkyl, \u2014C 1-6  alkyl-OH; \u2014C 1-6  alkyl, \u2014C 1-6  substituted alkyl, \u2014C 3-6  cycloalkyl, \u2014COR 7 , \u2014COONR 22 R 23 , \u2014SOR 7 , and \u2014SONR 24 R 25 ; R 13  and R 14  are independently selected from \u2014H, \u2014C 1-6  alkyl, \u2014C 3-6  cycloalkyl, \u2014C 1-6  substituted alkyl, \u2014C 1-6  alkyl-Q 3 , \u2014C 1-6  alkyl-C 3-6  cycloalkyl-Q 3  and C 1-6  substituted alkyl-Q 3 , or R 13  and R 14  are taken together with the adjacent N to form a cycle selected from: Q 3  is selected from heteroaryl, substituted heteroaryl, \u2014NR 20 R 21 ,  \u2212 CONR 2 R 2 , \u2014COOR 2 , \u2014OR 2 , and \u2014SO 2 R 3 ; R 15  is selected from \u2014C 1-6  alkyl, \u2014C 3-6  cycloalkyl, \u2014C 1-6  substituted alkyl, \u2014C 1-6  alkyl-Q 3 , \u2014C 1-6  alkyl-C 3-6  cycloalkyl-Q 3  and \u2014C 1-6  substituted alkyl-Q 3 ; R 16  is selected from \u2014H, \u2014C 1-6  alkyl, \u2014NR 2 R 2 , and \u2014COOR 3 ; R 17  is selected from \u2014H, \u2014C 1-6  alkyl, \u2014COOR 3 , and aryl; R 18  is selected from \u2014COOR 2  and \u2014C 1-6  alkyl-COOR 2 ; R 19  is selected from \u2014H, \u2014C 1-6  alkyl, \u2014C 1-6  alkyl-Q 4 , \u2014COR 3 , \u2014COOR 3 , wherein Q 4  is selected from \u2014NR 2 R 2  and \u2014OR 2 ; R 20  and R 21  are independently selected from \u2014H, \u2014C 1-6  alkyl, \u2014C 1-6  substituted alkyl, \u2014C 1-6  substituted alkyl-OR 2 , and \u2014COR 3 , or R 20  and R 21  are taken together with the adjacent N to form a cycle selected from with the proviso that only one of R 20  or R 21  can be \u2014COR 3 ; R 22  and R 23  are independently selected from H, \u2014C 1-6  alkyl, \u2014C 1-6  substituted alkyl, and \u2014C 1-6  cycloalkyl, or R 22  and R 23  are taken together with the adjacent N to form a cycle selected from R 24  and R 25  are independently from the group of H, \u2014C 1-6  alkyl, \u2014C 1-6  substituted alkyl, \u2014C 1-6  alkyl-Q 5 , \u2014C 1-6  cycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl, and Q 5  is selected from halogen and SO 2 R 3 , R 26  and R 27  are independently selected from \u2014H, \u2014C 1-6  alkyl, \u2014C 1-6  substituted alkyl, aryl, heteroaryl, substituted aryl, substituted heteroaryl, \u2014C 1-6  alkyl-Q 2 , or R 26  and R 27  are taken together with the adjacent N to form a cycle selected from:

Metadata:
- Claim Count in Document: 1.0
- Percentile: 98.0
- Lexical Diversity: 1.30952
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13359727', '14186533', '14682179', '13760726', '13151722']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8649353978061642
- 35 USC 102 Novelty (BERT): 0.6077510593237514
- Combined Prediction Score: 0.839216963957923
- Mean Citation Score: 563.4809799999998
- Max Citation Score: 580.354
- Similarity Product: 479.5268765618802

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test