PATENT CLAIM ANALYSIS

Application Number: 15757269
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-12
Patent Classification: ["424", "450000"]

Abstract:
The present disclosure is directed to methods of producing monosized protocells from monosized mesoporous silica nanoparticles (mMSNPs) and their use for targeted drug delivery formulations and systems and for biomedical applications. The present disclosure is also directed in part to a multilamellar or unilamellar protocell vaccine to deliver full length viral protein and/or plasmid encoded viral protein to antigen presenting cells (APCs) in order to induce an immunogenic response to a virus.

Claim (Index 25):
The population of protocells of  claim 1 , which comprises a plurality of multilamellar comprising:\n a nanoporous silica or metal oxide core and a multilamellar lipid bi-layer coating said core, the multilamellar lipid bi-layer comprising at least an inner lipid bi-layer and an outer lipid bi-layer and optionally an inner aqueous layer and/or an outer aqueous layer, said inner aqueous layer separating said core from said inner lipid bi-layer and said outer aqueous layer separating said inner lipid bi-layer from said outer lipid bi-layer said outer lipid bi-layer comprising: at least one Toll-like receptor (TLR) agonist; a fusogenic peptide; and optionally at least one cell targeting species which selectively binds to a target on antigen presenting cells (APCs); said inner lipid bi-layer comprising an endosomolytic peptide.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 90.0
- Lexical Diversity: 1.36842
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14113371', '13143164', '12909572', '15320903', '14354706']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7313626390788472
- 35 USC 102 Novelty (BERT): 0.5595100208744044
- Combined Prediction Score: 0.7141773772584029
- Mean Citation Score: 348.0356040000001
- Max Citation Score: 464.6732
- Similarity Product: 333.6017036952496

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test