PATENT CLAIM ANALYSIS

Application Number: 16084979
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["544", "155000"]

Abstract:
An octahydroanthracene compound having the structure shown in formula (I) and (II), preparation method and application thereof are disclosed. The octahydroanthracene compound has a good therapeutic effect on tumors and neurodegenerative diseases. The preparation of the octahydroanthracene compound is mainly carried out by using benzene as a starting material, and being subjected to Friedel-Crafts reaction, nitration, reduction, (sulfo-) amide formation, reduction, urea formation or amide formation, thus obtaining a target compound.

Claim (Index 6):
An octahydroanthracene compound and pharmaceutically acceptable salts of the octahydroanthracene compound, selecting from:\n 4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] methyl benzoate; 4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] benzoic acid; N-hydroxy-4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] benzamide; N-(2-aminophenyl)-4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4 5,6,7,8-octahydro-9-anthryl) carbamoyl] benzamide; N[2-(N,N-diethylamino)]ethyl-4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] benzamide; N-(2-amino) ethyl -4[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] benzamide; N-[2(N,N-dimethylamino)]ethyl-4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] benzamide; N-(2-hydroxyphenyl)-4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] benzamide; 4-[(1,1,4,4,5,5,8,8-octamethyl-1,23,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] aniline; 4-[(1,1,4,4,5,5,8,8-octamethyl-1,23,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] ethyl phenylcarbamate; 4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl carbamoyl-1-morpholine; 1-(2-aminophenyl)-3-{4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl} urea; 1-(2-amino) ethyl-3-{4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl} urea; 1-(2-hydroxy) ethyl-3-{4[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl} urea; 1-(3-hydroxy)propyl-3-{4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl} urea; N,N-dimethylsulfonyl-4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,5,6,7,8-octahydro-9-anthryl) carbamoyl] aniline; 1-(4-carboxypropyl)-3-{4-[(1,1,4,4,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl} urea; N-{4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenylcarbamoyl}-4-piperidinyl formic acid; 4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] methyl phenylcarbamate; 1-(2-hydroxyphenyl)-3-{4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl} urea; 1-[2-(N,N-diethylamino)]ethyl-3-{4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl} urea; 1-[2-(N,N-dimethylamino)]ethyl-3-{4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl} urea; 1-hydroxy-3-{(4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl} urea; 4-[(1,1,4,4,5,5,8,8-octamethyl-1,2,3,4,5,6,7,8-octahydro-9-anthryl) carbamoyl] phenyl carbamic acid-O-amino ester.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 97.0
- Lexical Diversity: 1.51724
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14291860', '14342953', '14009418', '13407520', '15527975']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.751484494949084
- 35 USC 102 Novelty (BERT): 0.5039742336551828
- Combined Prediction Score: 0.7267334688196938
- Mean Citation Score: 237.793098
- Max Citation Score: 256.24344
- Similarity Product: 193.36934589577683

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test