PATENT CLAIM ANALYSIS

Application Number: 15987365
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "256000"]

Abstract:
This invention provides for an improved method for differentially diagnosing ACTH-dependent Cushing's syndrome. Current practice for differentially diagnosing ectopic ACTH syndrome and Cushing's Disease measures relative ACTH concentrations from the inferior petrosal venous sinus compared to fluid obtained from a periphery venous sample. This is performed before and after administration of exogenous corticotropin releasing factor, or after administration of metyrapone. This invention uses glucocorticoid receptor antagonists to induce release of endogenous CRH which stimulates ACTH to increase in patients with ectopic ACTH syndrome but not in those with Cushing's Disease.

Claim (Index 18):
The method of  claim 16 , wherein the octahydro fused azadecalin has the formula: wherein R 1  is a heteroaryl ring having from 5 to 6 ring members and from 1 to 4 heteroatoms each independently selected from the group consisting of N, O and S, optionally substituted with 1-4 groups each independently selected from R 1a ; each R 1a  is independently selected from the group consisting of hydrogen, C 1-6  alkyl, halogen, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, N-oxide, and C 3-8  cycloalkyl; ring J is selected from the group consisting of an aryl ring and a heteroaryl ring having from 5 to 6 ring members and from 1 to 4 heteroatoms each independently selected from the group consisting of N, O and S; each R 2  is independently selected from the group consisting of hydrogen, C 1-6  alkyl, halogen, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkyl-C 1-6  alkoxy, CN, OH, NR 2a R 2b , C(O)R 2a , C(O)OR 2a , C(O)NR 2a R 2b , SR 2a , S(O)R 2a , S(O) 2 R 2a , C 3-8  cycloalkyl, and C 3-8  heterocycloalkyl having from 1 to 3 heteroatoms each independently selected from the group consisting of N, O and S; alternatively, two R 2  groups on adjacent ring atoms are combined to form a heterocycloalkyl ring having from 5 to 6 ring members and from 1 to 3 heteroatoms each independently selected from the group consisting of N, O and S, wherein the heterocycloalkyl ring is optionally substituted with from 1 to 3 R 2c  groups; R 2a , R 2b  and R 2c  are each independently selected from the group consisting of hydrogen and C 1-6  alkyl; each R 3a  is independently halogen; and subscript n is an integer from 0 to 3, or salts and isomers thereof.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 93.0
- Lexical Diversity: 1.48485
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15236015', '15796443', '15627414', '15697878', '15915477']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8201389175166337
- 35 USC 102 Novelty (BERT): 0.6969318683193075
- Combined Prediction Score: 0.807818212596901
- Mean Citation Score: 512.1089400000002
- Max Citation Score: 713.4526
- Similarity Product: 707.0982886079905

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test