PATENT CLAIM ANALYSIS

Application Number: 16149589
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["424", "131100"]

Abstract:
Described herein are methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring based on the level of TIGIT, Flg2 and/or IL-33 expression and/or activity. In some embodiments, the methods and compositions described herein are directed to treatment and/or therapy monitoring of cancer and/or infections (e.g., chronic viral infection, intracellular and/or extracellular bacterial infection, and/or fungal infection). In some embodiments, the methods and compositions described herein are directed to treatment and/or therapy monitoring of autoimmune diseases and/or inflammation (e.g., caused by parasitic infection). In some embodiments, the methods and compositions described herein are directed to treatment and/or therapy monitoring of asthma, allergy, and/or atopy. Methods for identifying patients who are more likely to be responsive to and benefit from an immunotherapy that targets TIGIT, Fg12 and/or IL-33 are also described herein.

Claim (Index 157):
A method of treating cancer in a subject in need thereof, comprising:\n a. receiving results of an assay measuring the level of Fgl2 in a sample from the subject; b. comparing the results received in step (a) to a reference; and\n i) when the level of Fgl2 is greater than the Fgl2 reference, administering an TIGIT antagonist antibody to the subject; or \n ii) when the level of Fgl2 is the same as or less than the Fgl2 reference, administering a suppressor of an anti-inflammatory T cell response pathway; \n whereby the subject's cancer is treated.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 97.0
- Lexical Diversity: 2.23188
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14004438', '15311712', '15239524', '15239569', '14333375']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6674415279539518
- 35 USC 102 Novelty (BERT): 0.5216091916185635
- Combined Prediction Score: 0.6528582943204131
- Mean Citation Score: 271.37580799999995
- Max Citation Score: 280.50778
- Similarity Product: 175.77287037200455

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test