PATENT CLAIM ANALYSIS

Application Number: 15747742
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-12
Patent Classification: ["424", "093200"]

Abstract:
A recombinant Herpes Simplex Virus type 1 (HSV-1) strain H129-derived anterograde multi-synaptic transneuronal viral tracer for multi-synaptic neural circuit mapping comprises two or more fluorescence expression cassettes being integrated into the H129 genome at different locations; wherein each fluorescence expression cassette contains at least two copies of fluorescent protein-encoding sequence that are arranged in tandem, and at least one linker-encoding sequence, where at least one linker-encoding sequence is disposed between two fluorescent protein-encoding sequences, allowing transcription of fluorescent protein-encoding sequences and linker-encoding sequence as a single transcript; and wherein the linker-encoding sequence encodes a linker peptide containing at least two adjacent amino acids that are highly inefficient in forming a peptide bond between them; thereby, when the single transcript is translated, at least two fluorescent proteins are stoichiometrically generated due to the impedence of peptide bond formation by the linker peptide.

Claim (Index 2):
The recombinant H129-derived anterograde multi-synaptic transneuronal viral tracer of  claim 1 , wherein the fluorescence expression cassette further comprises a promoter, wherein the promoter controls transcription of the fluorescent protein-encoding constructs and linker-encoding sequence.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 86.0
- Lexical Diversity: 1.65217
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14478870', '14388268', '15737712', '10893584', '10817961']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7335710552385383
- 35 USC 102 Novelty (BERT): 0.5037492601981133
- Combined Prediction Score: 0.7105888757344958
- Mean Citation Score: 226.40245
- Max Citation Score: 249.27774
- Similarity Product: 173.3593147694886

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test