PATENT CLAIM ANALYSIS

Application Number: 16366806
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["435", "462000"]

Abstract:
The present invention provides for a process for transferring biomolecules such as polynucleotides and protein from cell to cell, eventually resulting in the transport of a biomolecular cargo throughout the entirety of one or more of a cell culture, tissue, organ, organ system, or organism. The method also includes translocation of an SIF construct complex into a cell.

Claim (Index 1):
A method for generating a Self-Iterating Factor (SIF) which functions as an intra-luminal vesicle translocation enabler within a viral vector complex involving a genetic construct of exosomal shuttle DNA, the method comprising:\n a. generating a Vaccinia viral construct containing genetic DNA loci that encode an intra-luminal vesicle translocation factor known as a SIF at one locus and allow said SIF to bind to another locus; b. transducing a cell with a virally packaged SIF construct for cytoplasmic unloading and cytoplasmic transcriptional activation; c. entering the genetic construct into cytoplasma of the cell; d. translocating the SIF-construct complex into an intra-luminal vesicle (ILV) of a multi-vesicular body (MVB) with the SIF; e. containing the SIF-construct complex within the ILV until it is released into the extracellular space as an exosome containing exosomal shuttle DNA (esDNA); and f. fusing the exosome with a target cell; and releasing the SIF-construct complex into the cytoplasm to transfect the target cell.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 99.0
- Lexical Diversity: 1.41304
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14750457', '10485360', '15476844', '11799148', '16201937']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5027653162404523
- 35 USC 102 Novelty (BERT): 0.4761408392061479
- Combined Prediction Score: 0.5001028685370219
- Mean Citation Score: 138.672676
- Max Citation Score: 148.8827
- Similarity Product: 107.03465194436907

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test