PATENT CLAIM ANALYSIS

Application Number: 16036375
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "179000"]

Abstract:
The invention provides inhibitors of α-crystallin aggregation and methods of using α-crystallin aggregation inhibitors to, e.g., treat or prevent cataracts in a subject having or at risk of developing cataracts. The invention further provides high throughput methods of screening compounds for modulation of protein thermal stability, the method comprising contacting a protein with each of a plurality of test compounds; and (b) measuring the melting transition (T m ) of the protein in the presence of each of the plurality of test compounds, wherein a compound that decreases or increases the apparent T m  by at least 2 standard deviations is identified as a pharmacological protein chaperone.

Claim (Index 1):
A method of treating or preventing cataract, the method comprising administering to an individual in need thereof an effective amount of a composition comprising a compound of formula I: wherein:\n both R 1  are H or both R 1  are Me; \n R 2  is H or OH; \n dashed line between carbons 5 and 6 indicates an optional double bond; \n R 3  is H or Me; \n R 4  is H or Me; \n n is 0 or 1; \n (a) R 6  is \n and each R 5  is independently H or Me or (b) R 6  and one R 5  taken together form an optionally substituted 6-membered ring and the other R 5  is Me;\n the dashed line between carbons 12 and 13 is an optional double bond, with the proviso that R 7  is not present when the double bond between carbons 12 and 13 is present, and R 7  is H or Me when the double bond between carbons 12 and 13 is not present; R 8  is H or OH; both R 9  together form an oxo (\u2550O) or both R 9  are hydrogen; and R 10  is CO 2 H or linear or branched C 1 -C 6  alkyl; or a prodrug or pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 95.0
- Lexical Diversity: 1.69565
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13944477', '15423359', '15139192', '15221550', '13833008']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7370198412613647
- 35 USC 102 Novelty (BERT): 0.5538735419115578
- Combined Prediction Score: 0.718705211326384
- Mean Citation Score: 250.22456
- Max Citation Score: 442.4466
- Similarity Product: 262.14907040405274

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test