PATENT CLAIM ANALYSIS

Application Number: 16228535
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "261100"]

Abstract:
The invention relates to a compound of formula (I) wherein R 1  to R 4  are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Claim (Index 6):
The compound according to  claim 1  selected from the group consisting of:\n 5-tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-7-(1,2,5-triazaspiro[2.4]hept-1-en-5-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-[difluoro(phenyl)methyl]-7-(1,2,5-triazaspiro[2.4]hept-1-en-5-yl)-3-{[2-(trifluoromethyl)phenyl]methyl}-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-3-[(2-chlorophenyl)methyl]-7-(1,2,5-triazaspiro[2.4]hept-1-en-5-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({2-[3-(trifluoromethyl)-3H-diaziren-3-yl]phenyl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-3-[(2-ethynylphenyl)methyl]-7-(1,2,5-triazaspiro[2.4]hept-1-en-5-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 3-[(2-chlorophenyl)methyl]-5-[difluoro(phenyl)methyl]-7-(1,2,5-triazaspiro[2.4]hept-1-en-5-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-[difluoro(phenyl)methyl]-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-7-(1,2,5-triazaspiro[2.4]hept-1-en-5-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-3-({2-chloro-4-[3-(trifluoromethyl)-3H-diaziren-3-yl]phenyl}methyl)-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 4-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}-N-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethyl}-1,2,5-oxadiazole-3-carboxamide; \n 4-({5-tert-butyl-7-[(3 S)-3-hydroxypyrrolidin-1-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)-N-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethyl}-1,2,5-oxadiazole-3-carb oxamide; \n N-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethyl}-4-({5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)-1,2,5-oxadiazole-3-carb oxamide; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3 S)-1-[5-tert-butyl-3-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n (3 S)-1-{5-[difluoro(phenyl)methyl]-3-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}pyrrolidin-3-ol; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({4-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-3-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3 S)-1-[5-tert-butyl-3-({4-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-3-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3-({4-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-3-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3 S)-1-{5-[difluoro(phenyl)methyl]-3-({4-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-3-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}pyrrolidin-3-ol; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyrimidin-4-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3 S)-1-[5-tert-butyl-3-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyrimidin-4-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyrimidin-4-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3 S)-1-{5-[difluoro(phenyl)methyl]-3-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyrimidin-4-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}pyrrolidin-3-ol; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-4-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3 S)-1-[5-tert-butyl-3-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-4-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-4-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n (3 S)-1-{5-[difluoro(phenyl)methyl]-3-({3-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-4-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl}pyrrolidin-3-ol; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({4-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-2-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({5-[3-(trifluoromethyl)-3H-diaziren-3-yl]pyridin-3-yl}methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}-N-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethyl}-3-methyl-1,2-oxazole-4-carb oxamide; \n N-[(4-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}-1,2,5-oxadiazol-3-yl)methyl]-2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethan-1-amine; \n 5-tert-butyl-3-{[4-({2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethoxy}methyl)-1,2,5-oxadiazol-3-yl]methyl}-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]-N-{[4-({5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)-1,2,5-oxadiazol-3-yl]methyl)}ethan-1-amine; \n 3-{[4-({2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethoxy}methyl)-1,2,5-oxadiazol-3-yl]methyl})-5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-3-[(2-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethoxy}phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n 2-{[5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]methyl}-N-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethyl}aniline; \n 3-[(2-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethoxy}phenyl)methyl]-5[-difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; \n N-{2-[3-(but-3-yn-1-yl)-3H-diaziren-3-yl]ethyl}-2-({5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl}methyl)aniline; \n 5-[difluoro(phenyl)methyl]-3-[(2-ethynylphenyl)methyl]-7-(1,2,6-triazaspiro[2.4]hept-1-en-6-yl)triazolo[4,5-d]pyrimidine; \n 5-[difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2-ethynyl-6-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methyl]triazolo[4,5-d]pyrimidine; \n 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2-ethynyl-6-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methyl]triazolo[4,5-d]pyrimidine; \n (3S)-1-[5-tert-butyl-3-[[2-ethynyl-6-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; and \n (3S)-1-[5-[difluoro(phenyl)methyl]-3-[[2-ethynyl-6-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 98.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16228546', '16228539', '13669610', '16228543', '15332398']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8453236427197797
- 35 USC 102 Novelty (BERT): 0.6732454400089907
- Combined Prediction Score: 0.8281158224487007
- Mean Citation Score: 573.2305140000002
- Max Citation Score: 706.7309
- Similarity Product: 638.1366765982211

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test