PATENT CLAIM ANALYSIS

Application Number: 16201836
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["435", "440000"]

Abstract:
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Claim (Index 1):
A single-molecule DNA-targeting RNA having the structure: wherein the linker is GAAA and the nucleotide sequence of the single-molecule DNA-targeting RNA is GAUUUCUUCUUGCGCUUUUUGUUUUAGAGCUAGAAAUAGCAAGUUAAAAUAAGGCUAG UCCG (SEQ ID NO: 321).

Metadata:
- Claim Count in Document: 2.0
- Percentile: 98.0
- Lexical Diversity: 2.25424
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15435233', '16033005', '16033002', '15138604', '16201853']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.4154150177180519
- 35 USC 102 Novelty (BERT): 0.6114413157120183
- Combined Prediction Score: 0.4350176475174486
- Mean Citation Score: 600.3878139999998
- Max Citation Score: 600.44037
- Similarity Product: 456.3432648421455

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test