PATENT CLAIM ANALYSIS

Application Number: 16093160
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-06
Patent Classification: ["514", "267000"]

Abstract:
The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein B, R 1 , R 5 , Q 1 , Q″, L, X, Y, and Z are as defined as set forth in the specification. The present disclosure also provids compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.

Claim (Index 1):
A compound having Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: B is selected from the group consisting of: R 1  is selected from the group consisting of optionally substituted aryl, optionally substituted heteroaryl, and \u2014N(H)R 3 ; Q 1  is \u2550CH\u2014 and Q 2  is \u2014N\u2550; or Q 1  is \u2550N\u2014 and Q 2  is \u2014CH\u2550; or Q 1  is \u2550N\u2014 and Q 2  is \u2014N\u2550; R 3  is selected from the group consisting of optionally substituted aryl and optionally substituted heteroaryl; X is selected from the group consisting of \u2014C(\u2550O)N(R 2a )\u2014, \u2014CH 2 N(R 2b )\u2014, \u2014CH 2 O\u2014, \u2014N(R 2c )\u2014, \u2014O\u2014, and \u2014CH 2 \u2014; wherein the nitrogen atom of \u2014C(\u2550O)N(R 2a )\u2014 and \u2014CH 2 N(R 2b )\u2014 is attached to L, and the oxygen atom of \u2014CH 2 O\u2014 is attached to L; L is selected from the group consisting of alkylenyl, heteroalkylenyl, and \u2014(CH 2 ) m \u2014W\u2014(CH 2 ) n \u2014; W is selected from the group consisting of optionally substituted phenylenyl, optionally substituted 5-membered heteroarylenyl, and optionally substituted 6-membered heteroarylenyl; m is 0, 1, 2, 3, 4, 5, 6, or 7; n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; Y is selected from the group consisting of \u2014C\u2261C\u2014, \u2014CH 2 \u2014, \u2014O\u2014, \u2014N(R 2d )\u2014, \u2014C(\u2550O)N(R 2e )\u2014, \u2014N(R 2f )C(\u2550O)CH 2 O\u2014, and \u2014N(R 2g )C(\u2550O)CH 2 N(R 2h )\u2014; or Y is absent; wherein the carboxamide nitrogen atom of \u2014N(R 2f )C(\u2550O)CH 2 O\u2014 and \u2014N(R 2g )C(\u2550O)CH 2 N(R 2h )\u2014, and the carbon atom of \u2014C(\u2550O)N(R 2e )\u2014 is attached to L; R 2a , R 2b , R 2c , R 2d , R 2e , R 2f , R 2g , and R 2h  are each independently selected from the group consisting of hydrogen and C 1-4  alkyl; Z is selected from the group consisting of \u2014CH 2  and \u2014C(\u2550O)\u2014; and R 5  is selected from the group consisting of hydrogen and fluoro, with the proviso that Y is absent when B is B-2.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 97.0
- Lexical Diversity: 1.47273
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14204076', '15619671', '14633360', '15443336', '15553593']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8398678780180069
- 35 USC 102 Novelty (BERT): 0.5540640952203083
- Combined Prediction Score: 0.811287499738237
- Mean Citation Score: 383.15725
- Max Citation Score: 427.83923
- Similarity Product: 365.3918018962139

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test