PATENT CLAIM ANALYSIS

Application Number: 15748268
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2019-01
Patent Classification: ["424", "130100"]

Abstract:
An antibody production process in mammalian cells in which engineered unpaired cysteine residues are post-translationally modified and capped with particular chemical entities, which capped antibodies are well suited to further site-specific conjugation steps to form antibody-drug conjugates (ADCs) or protein drug conjugates; ADCs produced using these capped antibodies including in particular ADCs formed by the selective reduction of the capped antibodies' cysteine residues, and ADCs formed using chemical handles such as aldehyde/azide/alkyne biorthogonal groups, which permit additional drug conjugation chemistry; and uncapped antibodies produced by cells in low cysteine, cysteine and glutathione media, and ADCs produced via direct conjugation to these uncapped antibodies.

Claim (Index 2):
The method of  claim 1 , wherein said predetermined capping moiety is selected from the group consisting of 5-thio-2-nitrobenzoic acid (TNB), 2-mercaptopyridine, dithiodipyridine (DTDP), 4-thiobenzoic acid, 2-thiobenzoic acid, 4-thiobenzenesulfonic acid, 2-thiobenzenesulfonic acid, methyl sulfonate (Ms), p-toluenesulfonate (Ts) and trifluoromethanesulfonate (Tf).

Metadata:
- Claim Count in Document: 9.0
- Percentile: 86.0
- Lexical Diversity: 1.70149
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15356750', '14908492', '15117254', '15512030', '11255528']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7809894756544375
- 35 USC 102 Novelty (BERT): 0.5302877695990165
- Combined Prediction Score: 0.7559193050488954
- Mean Citation Score: 288.46417600000007
- Max Citation Score: 361.83197
- Similarity Product: 241.9004827007616

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test