PATENT CLAIM ANALYSIS

Application Number: 16160724
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "002900"]

Abstract:
In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Claim (Index 1):
A compound having a structure represented by a formula: wherein Y is R 80  or \u2014NH-(L) q -Ar 1 ;\n wherein R 80  is selected from (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, \u2014(C1-C8) alkyl-(C3-C8 cycloalkyl), \u2014(C1-C8) alkyl-(C3-C8 cycloalkenyl), \u2014(C2-C8) alkenyl-(C3-C8 cycloalkyl), and \u2014(C1-C8) alkenyl-(C3-C8 cycloalkenyl); \n wherein q is an integer selected from 0 and 1; \n wherein L is moiety selected from \u2014CH 2 \u2014, \u2014(CH 2 ) 2 \u2014, \u2014CH\u2550CH\u2014, and -(cyclopropyl)-; \n wherein each of R 1a  and R 1b  is independently selected from hydrogen, halogen, hydroxyl, cyano, and C1-C3 alkyl; or wherein R 1a  and R 1b  are optionally covalently bonded, and together with the intermediate carbon comprise an optionally substituted 3- to 7-membered spirocycloalkyl; wherein R 2  is selected from hydrogen, halogen, \u2014NH 2 , \u2014OH, \u2014NO 2 , C1-C3 alkyl, \u2014C1-C3 hydroxyalkyl, \u2014C1-C3 alkylamino, C1-C3 dialkylamino, and C1-C3 aminoalkyl; or wherein R 2  is \u2014(C0-C6)-G; wherein R 3  is selected from C1-C6 alkyl and C1-C6 hydroxyalkyl; wherein R 4  is selected from hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, and C1-C6 alkylamino; or wherein R 4  is \u2014(C0-C6)-G, provided at least one of R 2  and R 4  is \u2014(C0-C6)-G; or wherein R 3  and R 4  are covalently bonded and, together with the intermediate atoms, comprise a 3- to 10-membered heterocycle having 1, 2, or 3 heteroatoms selected from O, N, and S; and wherein the heterocycle is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014NH 2 , \u2014OH, \u2014NO 2 , C1-C3 alkyl, C1-C3 alkoxy, C1-C3 aminoalkyl, C1-C3 alkylamino, C1-C3 dialkylamino, C1-C3 hydroxyalkyl, \u2014(C\u2550O)OR 30 , \u2014(C\u2550O)NR 32a R 32b , \u2014(C1-C3 alkyl)-(C\u2550O)OR 30 , \u2014(C1-C3 alkyl)-(C\u2550O)NR 32a R 32b , and \u2014(C0-C6)-G; provided that the heterocycle is substituted with at least one group that is \u2014(C0-C6)-G when R 2  is not \u2014(C0-C6)-G;\n wherein R 30 , when present, is selected from hydrogen and C1-C3 alkyl; \n wherein each of R 32a  and R 32b , when present, is independently selected from hydrogen and C1-C3 alkyl; \n wherein G has a structure represented by a formula selected from: wherein each of R 5a , R 5b , and R 5c  is independently selected from hydrogen, halogen, difluoromethoxy, and trifluoromethoxy; wherein each of R 70a  and R 70b  is independently selected from hydrogen, methyl, and ethyl; wherein Ar 1  is selected from aryl and heteroaryl; and wherein Ar 1  is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014NH 2 , \u2014OH, \u2014NO 2 , difluoromethoxy, trifluoromethoxy, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, C1-C6 dialkylamino, \u2014S(O) n R 40 , \u2014S(O) n NR 41a R 41b , \u2014(C\u2550O)NR 42a R 42b , \u2014NR 43  (C\u2550O)NR 44a R 44b , \u2014NR 43 (C\u2550O)R 45 , \u2014(C\u2550O)OR 46 , Ar 2 , \u2014(C1-C3 alkyl)-S(O) n R 40 , \u2014(C1-C3 alkyl)-S(O) n NR 41a R 41b , \u2014(C1-C3 alkyl)-(C\u2550O)NR 42a R 42b , \u2014(C1-C3 alkyl)-NR 43 (C\u2550O)NR 44a R 44b , \u2014NR 43 (C\u2550O)R 45 , \u2014(C1-C3 alkyl)-(C\u2550O)OR 46 , and \u2014(C1-C3 alkyl)-Ar 2 ;\n wherein each n is an integer independently selected from 0, 1, and 2; \n wherein each occurrence of R 40 , when present, is independently selected from hydrogen, C1-C6 alkyl, phenyl, benzyl, naphthyl, and monocyclic heteroaryl; \n wherein each occurrence of R 41a  and R 41b , when present, is independently selected from hydrogen, C1-C6 alkyl, phenyl, benzyl, naphthyl, and monocyclic heteroaryl; \n wherein each occurrence of R 42 , when present, is independently selected from hydrogen and C1-C6 alkyl; \n wherein each occurrence of R 43 , when present, is independently selected from hydrogen and C1-C6 alkyl; \n wherein each occurrence of R 44a  and R 44b , when present, is independently selected from hydrogen and C1-C6 alkyl; \n wherein each occurrence of R 45 , when present, is independently selected from hydrogen and C1-C6 alkyl; \n wherein each occurrence of R 46 , when present, is independently selected from hydrogen and C1-C6 alkyl; \n wherein each Ar 2 , when present, is independently selected from phenyl, naphthyl, and heteroaryl, and wherein each Ar 2  is independently substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014NH 2 , \u2014OH, \u2014CN, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, and C1-C6 dialkylamino; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 46.0
- Percentile: 97.0
- Lexical Diversity: 1.51852
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15554707', '14914449', '16329168', '15863673', '14380659']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8802376970063784
- 35 USC 102 Novelty (BERT): 0.6487766807441482
- Combined Prediction Score: 0.8570915953801554
- Mean Citation Score: 654.553988
- Max Citation Score: 800.62445
- Similarity Product: 568.2041172685922

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test