PATENT CLAIM ANALYSIS

Application Number: 16033446
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["514", "387000"]

Abstract:
The invention relates to 1,3-diaza-spiro-[3.4]-octane derivatives, their preparation and use in medicine, particularly in various neurological disorders, including but not limited to pain, neurodegenerative disorders, neuroinflammatory disorders, neuropsychiatric disorders, substance abuse/dependence.

Claim (Index 57):
The compound according to  claim 1 , which is selected from the group consisting of\n 2-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)acetamide 2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro-[3.4]-octan-6-one 5-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxy-pyrimidine-2-carbonitrile 5-(cyclobutylmethyl)-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one 2-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)acetamide 5-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxypyrimidine-2-carbonitrile 2-(dimethylamino)-7-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one 7-(6-(azetidin-1-yl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one 5-(2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-4-methylpicolino-nitrile 5-(5-(cyclopropyl methyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-4-methyl-picolinonitrile 6-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-5-methyl-nicotinonitrile 2-(dimethylamino)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]-octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one 2-(dimethylamino)-7-(4-methyl-6-morpholinopyridin-3-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one 2-(dimethylamino)-7-(6-(2-hydroxypropan-2-yl)-4-methylpyridin-3-yl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one 2-(dimethylamino)-7-(4-(2-hydroxypropan-2-yl)-2-methylphenyl)-2-phenyl-5,7-diazaspiro[3.4]-octan-6-one 7-(6-(difluoromethyl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-(3-fluorophenyl)-5,7-diazaspiro-[3.4]octan-6-one 2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropyl methyl)-7-(6-(difluoromethyl)-4-methyl pyridin-3-yl)-2-(dimethylamino)-2-(3-fluoro-phenyl)-5,7-diazaspiro[3.4]octan-6-one 2-(dimethylamino)-7-(2-morpholinopyrimidin-5-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one 2-(dimethylamino)-5-((1-fluorocyclopropyl)methyl)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one 2-(dimethylamino)-2-(3-fluorophenyl)-5-((1-hydroxycyclobutyl)methyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(4-(2-hydroxypropan-2-yl)phenyl)-5,7-diazaspiro[3.4]octan-6-one 2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-phenyl-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(2-(methylsulfonyl)ethyl)-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-7-((3-fluorooxetan-3-yl)methyl)-2-(3-fluorophenyl)-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-7-(6-cyclopropylpyridin-3-yl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one 7-(6-cyclopropyl-4-methylpyridin-3-yl)-5-(cyclopropyl methyl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one 7-(6-cyclopropyl-4-methylpyridin-3-yl)-2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(2-methoxy-2-methylpropyl)-5,7-diazaspiro[3.4]octan-6-one 2-(dimethylamino)-2-phenyl-7-(2-pyridin-4-ylpyrimidin-5-yl)-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-[5-(trifluoromethyl)pyridin-3-yl]-5,7-diazaspiro[3.4]octan-6-one 5-[5-(cyclopropylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile 2-(dimethylamino)-2-(3-fluorophenyl)-7-(4-morpholinobenzyl)-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-[(1-hydroxycyclobutyl)methyl]-5,7-diazaspiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-(2-pyridin-4-ylpyrimidin-5-yl)-5,7-diaza-spiro[3.4]octan-6-one 3-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)propanenitrile 3-[5-(cyclopropylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl]-propanenitrile 5-(cyclopropylmethyl)-2-(dimethylamino)-7-[(1-hydroxycyclobutyl)methyl]-2-phenyl-5,7-diaza-spiro[3.4]octan-6-one 5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-[2-(oxetan-3-yl)ethyl]-5,7-diaza-spiro[3.4]octan-6-one cis-2-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)acetamide cis-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one cis-5-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxy-pyrimidine-2-carbonitrile trans-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one trans-5-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxy-pyrimidine-2-carbonitrile cis-5-(cyclobutylmethyl)-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxo-ethyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one trans-5-(cyclobutylmethyl)-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one cis-2-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl-)acetamide trans-2-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]-octan-7-yl)-acetamide cis-5-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxypyrimidine-2-carbonitrile trans-5-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]-octan-7-yl)-4-methoxypyrimidine-2-carbonitrile cis-2-(dimethylamino)-7-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one cis-7-(6-(azetidin-1-yl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one cis-5-(2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-4-methyl-picolinonitrile cis-5-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-4-methylpicolinonitrile cis-6-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-5-methylnicotinonitrile cis-2-(dimethylamino)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]-octan-6-one cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one cis-2-(dimethylamino)-7-(4-methyl-6-morpholinopyridin-3-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one cis-2-(dimethylamino)-7-(6-(2-hydroxypropan-2-yl)-4-methylpyridin-3-yl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one cis-2-(dimethylamino)-7-(4-(2-hydroxypropan-2-yl)-2-methylphenyl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one cis-7-(6-(difluoromethyl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-(3-fluorophenyl)-5,7-diaza-spiro[3.4]octan-6-one cis-2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropylmethyl)-7-(6-(difluoromethyl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-(3-fluorophenyl)-5,7-diazaspiro[3.4]octan-6-one cis-2-(dimethylamino)-7-(2-morpholinopyrimidin-5-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one cis-2-(dimethylamino)-5-((1-fluorocyclopropyl)methyl)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one cis-2-(dimethylamino)-2-(3-fluorophenyl)-5-((1-hydroxycyclobutyl)methyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(4-(2-hydroxypropan-2-yl)-phenyl)-5,7-diazaspiro[3.4]octan-6-one cis-2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-phenyl-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(2-(methylsulfonyl)ethyl)-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropyl methyl)-2-(dimethylamino)-7-((3-fluorooxetan-3-yl)methyl)-2-(3-fluorophenyl)-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropyl methyl)-7-(6-cyclopropyl pyridin-3-yl)-2-(dimethylamino)-2-phenyl-5,7-diaza-spiro[3.4]octan-6-one cis-7-(6-cyclopropyl-4-methylpyridin-3-yl)-5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one cis-7-(6-cyclopropyl-4-methyl pyridin-3-yl)-2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropyl methyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(2-methoxy-2-methylpropyl)-5,7-diazaspiro[3.4]octan-6-one cis-2-(dimethylamino)-2-phenyl-7-(2-pyridin-4-ylpyrimidin-5-yl)-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropyl methyl)-2-(dimethylamino)-2-phenyl-7-[5-(trifluoromethyl)pyridin-3-yl]-5,7-diazaspiro[3.4]octan-6-one cis-5-[5-(cyclopropylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile cis-2-(dimethylamino)-2-(3-fluorophenyl)-7-(4-morpholinobenzyl)-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-[(1-hydroxycyclobutyl)methyl]-5,7-diazaspiro[3.4]octan-6-one cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-(2-pyridin-4-ylpyrimidin-5-yl)-5,7-diazaspiro[3.4]octan-6-one cis-3-(5-(cyclopropyl methyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)propane nitrile cis-3-[5-(cyclopropylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl]-pro pane nitrile cis-5-(cyclopropylmethyl)-2-(dimethylamino)-7-[(1-hydroxycyclobutyl)methyl]-2-phenyl-5,7-diaza-spiro[3.4]octan-6-one cis-5-(cyclopropyl methyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-[2-(oxetan-3-yl)ethyl]-5,7-diaza-spiro[3.4]octan-6-one and the physiologically acceptable salts thereof.

Metadata:
- Claim Count in Document: 57.0
- Percentile: 95.0
- Lexical Diversity: 1.34375
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15417953', '15969907', '15403741', '13483170', '12281317']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7578740704121273
- 35 USC 102 Novelty (BERT): 0.5341742862998341
- Combined Prediction Score: 0.7355040920008981
- Mean Citation Score: 333.198664
- Max Citation Score: 350.52203
- Similarity Product: 270.3993707940531

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test