PATENT CLAIM ANALYSIS

Application Number: 15980602
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-03
Patent Classification: ["800", "008000"]

Abstract:
The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.

Claim (Index 28):
A method of transplanting human cancer cells, comprising:\n transplanting human cancer cells into a genetically modified, immunodeficient mouse; and transplanting human hematopoietic cells into the genetically modified, immunodeficient mouse, wherein the genetically modified, immunodeficient mouse comprises in its genome a recombination activating gene 2 (Rag-2) gene knock-out, an IL2 receptor gamma chain (IL2rg) gene knock-out, a replacement of a mouse M-CSF gene with a nucleic acid encoding a human M-CSF polypeptide at a mouse M-CSF gene locus, a replacement of a mouse IL-3 gene with a nucleic acid encoding a human IL-3 polypeptide at a mouse IL-3 gene locus, a replacement of a mouse GM-CSF gene with a nucleic acid encoding a human GM-CSF polypeptide at a mouse GM-CSF gene locus, an insertion of a nucleic acid encoding a human SIRPA polypeptide, and a replacement of a mouse TPO gene with a nucleic acid encoding a human TPO polypeptide at a mouse TPO gene locus, wherein each of the nucleic acids encoding the human M-CSF polypeptide, the human IL-3 polypeptide, the human GM-CSF polypeptide, the human SIRPA polypeptide, and the human TPO polypeptide is operably linked to a promoter, and wherein the mouse expresses the human M-CSF polypeptide, the human IL-3 polypeptide, the human GM-CSF polypeptide, the human SIRPA polypeptide, and the human TPO polypeptide.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 93.0
- Lexical Diversity: 1.0
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14420318', '14072626', '15192903', '14715446', '14053182']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6610537446738134
- 35 USC 102 Novelty (BERT): 0.6838278667325208
- Combined Prediction Score: 0.6633311568796841
- Mean Citation Score: 588.717616
- Max Citation Score: 795.587
- Similarity Product: 695.9149890706539

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test