PATENT CLAIM ANALYSIS

Application Number: 15749191
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["536", "024500"]

Abstract:
Double-stranded modified siRNA targeting a RecQL1 helicase gene includes a sense strand including the nucleotide sequence shown in SEQ ID NO: 1, and an antisense strand including the nucleotide sequence shown in SEQ ID NO: 2, wherein the sense strand includes 2′-substituted nucleotides at positions 2, 3, 4 and 13 in the nucleotide sequence shown in SEQ ID NO: 1, the sense strand further includes a 2′-substituted nucleotide(s) at one or more positions selected from the group consisting of positions 12, 14, 17, 18 and 19 in the nucleotide sequence shown in SEQ ID NO: 1, wherein the position 2′ of the 2′-substituted nucleotides is —R 1 , —OR 1 , —R 2 OR 1 , —OR 2 OR 1  or —R 3 OR 2 OR 1 , wherein R 1  represents a C 1-4  alkyl group, and R 2  and R 3  independently represent a C 1-3  alkylene group.

Claim (Index 20):
The modified siRNA according to  claim 17 , wherein the sense strand comprises the 2\u2032-substituted nucleotides at the following positions in the nucleotide sequence shown in SEQ ID NO: 1:\n (a) positions 2, 3, 4, 11, 12, 13, 14, 17, 18 and 19, (b) positions 2, 3, 4, 11, 12, 13 and 14, (c) positions 2, 3, 4, 12, 13, 14, 17, 18 and 19, (d) positions 2, 3, 4, 13, 17, 18 and 19, (e) positions 2, 3, 4, 11, 12, 13, 14 and 17, (f) positions 2, 3, 4, 11, 12, 13, 14 and 18, (g) positions 2, 3, 4, 11, 12, 13, 14 and 19, (h) positions 2, 3, 4, 11, 12, 13, 14, 17 and 18, (i) positions 2, 3, 4, 11, 12, 13, 14, 17 and 19, (j) positions 2, 3, 4, 11, 12, 13, 14, 18 and 19, (k) positions 2, 3, 4, 12, 13, 17, 18 and 19, or (l) positions 2, 3, 4, 13, 14, 17, 18 and 19.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 2.47059
- Patent Class: 536.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12343342', '12673003', '15376633', '13764825', '11980102']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6961562844234874
- 35 USC 102 Novelty (BERT): 0.5244592275917181
- Combined Prediction Score: 0.6789865787403105
- Mean Citation Score: 348.36243
- Max Citation Score: 353.0999
- Similarity Product: 259.59523280603884

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test