PATENT CLAIM ANALYSIS

Application Number: 16129618
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["424", "133100"]

Abstract:
The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

Claim (Index 60):
A method of humanizing an antibody, the method comprising:\n (a) selecting one or more acceptor antibodies; (b) identifying the amino acid residues of the mouse antibody to be retained; (c) synthesizing a nucleic acid encoding a humanized heavy chain comprising CDRs of the mouse antibody heavy chain and a nucleic acid encoding a humanized light chain comprising CDRs of the mouse antibody light chain; and (d) expressing the nucleic acids in a host cell to produce a humanized antibody; wherein the mouse antibody is characterized by a mature heavy chain variable region of SEQ ID NO: 1 and a mature light chain variable region of SEQ ID NO: 16.

Metadata:
- Claim Count in Document: 273.0
- Percentile: 97.0
- Lexical Diversity: 1.64103
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15201423', '15201416', '15201429', '15861600', '15199236']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8441690234122078
- 35 USC 102 Novelty (BERT): 0.7232561261026006
- Combined Prediction Score: 0.832077733681247
- Mean Citation Score: 697.8904719999997
- Max Citation Score: 812.8804
- Similarity Product: 783.0749106610775

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test