PATENT CLAIM ANALYSIS

Application Number: 16129618
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["424", "133100"]

Abstract:
The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.

Claim (Index 18):
The humanized antibody of  claim 11  comprising a humanized mature heavy chain variable region having an amino acid sequence at least 90% identical to any one of SEQ ID NOS: 5-12 and a humanized mature light chain variable region having an amino acid sequence at least 90% identical to any one of SEQ ID NOS: 19-23, except that position H19 can be R or K, position H40 can be A or T, position H44 can be G or R, position H49 can be S or A, position H77 can be S or T, position H82a can be N or S, position H83 can be R or K, position H84 can be A or S, and position H89 can be V or M.

Metadata:
- Claim Count in Document: 273.0
- Percentile: 97.0
- Lexical Diversity: 1.64103
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15201423', '15201416', '15201429', '15861600', '15199236']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8478221897044496
- 35 USC 102 Novelty (BERT): 0.7070889736938868
- Combined Prediction Score: 0.8337488681033933
- Mean Citation Score: 697.8904719999997
- Max Citation Score: 812.8804
- Similarity Product: 735.9855302659512

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test