PATENT CLAIM ANALYSIS

Application Number: 16165987
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "044000"]

Abstract:
A genetically modified mouse is provided, wherein the mouse is incapable of rearranging and expressing an endogenous mouse immunoglobulin light chain variable sequence, wherein the mouse expresses only one or two human light chain variable domains encoded by human immunoglobulin sequences operably linked to the mouse kappa (κ) constant gene at the endogenous mouse κ locus, wherein the mouse expresses a reverse chimeric antibody having a light chain variable domain derived from one of only two human light chain variable region gene segments and a mouse κ constant domain, and a human heavy chain variable domain and a mouse heavy chain constant domain, from an endogenous mouse heavy chain locus. Bispecific epitope-binding proteins that are fully human are provided, comprising two different heavy chains that associate with an identical light chain that comprises a variable domain derived from one of two different human light chain variable region gene segments.

Claim (Index 26):
The genetically modified mouse of  claim 22 , wherein the single rearranged human immunoglobulin kappa light chain variable region sequence is a V\u03ba3-20/J\u03ba sequence.

Metadata:
- Claim Count in Document: 125.0
- Percentile: 97.0
- Lexical Diversity: 2.37313
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13022759', '16128360', '15700973', '14473970', '13832247']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8142895331081598
- 35 USC 102 Novelty (BERT): 0.6010082778028337
- Combined Prediction Score: 0.7929614075776271
- Mean Citation Score: 520.5982019999999
- Max Citation Score: 545.11975
- Similarity Product: 468.0140625815838

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test