PATENT CLAIM ANALYSIS

Application Number: 15868331
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["546", "185000"]

Abstract:
The present disclosure is related to an improved and efficient process for preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine which comprises: (a) N-acylation of 3-Amino-4-methyl pyridine; (b) Quarternization of 3-Acetylamino-4-methyl pyridine using benzyl halide; (c) Partial reduction of quarternized 3-Acetylamino-4-methyl pyridine by Sodium borohydride in Methanol or water; (d) Hydrolysis of partially reduced product to 1-Benzyl-4-methylpiperidin-3-one in presence of acid; (e) Reductive amination of 1-Benzyl-4-methylpiperidin-3-one using Methanolic methylamine in presence of Titanium(IV) isopropoxide in Methanol; (f) Resolution of 1-Benzyl-4-methylpiperidin-3-yl)-methylamine using Ditoluoyl (L) tartaric acid to get (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine. The disclosure is also related to novel intermediates: wherein R, R′ and X are as described in the specification.

Claim (Index 5):
The process of  claim 1 , wherein the first organic solvent comprises one or more of an aromatic solvent, a polar aprotic solvent, a non-polar solvents solvent, an ether solvent, an ester solvent, or a ketone solvent, and the first solvent optionally comprises water.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.76829
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14891028', '16306941', '10310078', '10720600', '11032990']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8147251337987168
- 35 USC 102 Novelty (BERT): 0.5980355482535655
- Combined Prediction Score: 0.7930561752442017
- Mean Citation Score: 373.796776
- Max Citation Score: 579.4216299999998
- Similarity Product: 445.37312391626887

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test