PATENT CLAIM ANALYSIS

Application Number: 15769844
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "227800"]

Abstract:
A compound represented by general formula [I] wherein X represents N or the like, Y represents CH or the like; R A  represents a cycloalkyl group which may be substituted or the like, R 1  represents an alkyl group or the like, R 2  represents an alkyl group which may be substituted or the like, R 3  represents a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof has an inhibitory activity on aldosterone synthetase, and is useful as a prophylactic and/or therapeutic agent for various diseases or symptoms associated with aldosterone.

Claim (Index 3):
The compound according to  claim 1  or  2 ,\n wherein \n substituents of the cycloalkyl group which may be substituted, the cycloalkenyl group which may be substituted, the aryl group which may be substituted, and the 6- to 10-membered monocyclic or bicyclic heteroaryl group which may be partially hydrogenated and may be substituted, represented by R A , are 1-3 groups each independently selected from the group consisting of a halogen atom, a cyano group, an alkyl group, a haloalkyl group, an alkoxyalkyl group, and an alkoxy group, \n in the aryl group which may be substituted, represented by R A , the aryl moiety is phenyl or naphthyl, \n in the 6- to 10-membered heteroaryl group which may be partially hydrogenated and may be substituted, represented by R A , the heteroaryl moiety is pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, thiazinyl, triazinyl, indolyl, isoindolyl, indazolyl, benzimidazolyl, benzothiazolyl, benzofuranyl, quinolyl, isoquinolyl, imidazopyridyl, or benzopyranyl; \n a substituent of (i) the alkyl group which may be substituted, represented by R 2 , is 1-3 groups independently selected from the group consisting of a halogen atom; a hydroxyl group; an oxo group; a carbamoyl group which may be substituted with 1-2 alkyl groups; an alkylsulfonyl group; an alkoxy group which may be substituted with a carbamoyl group which may be substituted with 1-2 alkyl groups; an aliphatic heterocyclic group which may be substituted with 1-3 groups independently selected from the group consisting of a hydroxyl group, an oxo group, an alkyl group, an alkylsulfonyl group, and an alkoxycarbonyl group; an alkoxycarbonyl group; an amino group which may be substituted with 1-2 groups independently selected from the group consisting of an alkyl group and an alkanoyl group; and a heteroaryl group, \n substituents of (ii) the cycloalkyl group which may be substituted, (iii) the aliphatic heterocyclic group which may be substituted, and (iv) the heteroaryl group which may be partially hydrogenated and may be substituted, represented by R 2 , are 1-3 groups each independently selected from the group consisting of a halogen atom; a hydroxyl group; an oxo group; an alkyl group which may be substituted with 1-3 groups independently selected from the group consisting of a hydroxyl group, a carbamoyl group which may be substituted with 1-2 alkyl groups, and an alkylsulfonyl group; an alkoxy group which may be substituted with a carbamoyl group which may be substituted with 1-2 alkyl groups; an aliphatic heterocyclic group which may be substituted with 1-3 groups independently selected from the group consisting of a hydroxyl group, an oxo group, an alkyl group, an alkylsulfonyl group, and alkoxycarbonyl group; an alkoxycarbonyl group; an amino group which may be substituted with 1-2 groups independently selected from the group consisting of an alkyl group and an alkanoyl group; and a heteroaryl group, \n in the respective substituents of the above (i) to (iv), the aliphatic heterocyclic group is a group independently selected from the group consisting of azetidinyl, oxetanyl, pyrrolidinyl, tetrahydrothienyl, tetrahydrofuranyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homomorpholinyl, tetrahydrothiopyranyl, tetrahydropyranyl, 1-azabicyclo[2.2.2]octyl(quinuclidinyl), 8-azabicyclo[3.2.1]octyl, 3-oxabicyclo[3.3.1]nonyl, and 3-oxo-9-azabicyclo[3.3.1]nonyl, \n in the respective substituents of the above (i) to (iv), the heteroaryl group is a group independently selected from the group consisting of pyrrolyl, furanyl, thienyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, thiazinyl, triazinyl, indolyl, isoindolyl, indazolyl, benzimidazolyl, benzothiazolyl, benzofuranyl, quinolyl, isoquinolyl, imidazopyridyl, and benzopyranyl, \n in the aliphatic heterocyclic group which may be substituted, represented by R 2 , the aliphatic heterocyclic moiety is azetidinyl, oxetanyl, pyrrolidinyl, tetrahydrothienyl, tetrahydrofuranyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homomorpholinyl, tetrahydrothiopyranyl, tetrahydropyranyl, 1-azabicyclo[2.2.2]octyl(quinuclidinyl), 8-azabicyclo[3.2.1]octyl, 3-oxabicyclo[3.3.1]nonyl, or 3-oxo-9-azabicyclo[3.3.1]nonyl, and \n in the heteroaryl group which may be partially hydrogenated and may be substituted, represented by R 2 , the heteroaryl moiety is pyrrolyl, furanyl, thienyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, thiazinyl, triazinyl, indolyl, isoindolyl, indazolyl, benzimidazolyl, benzothiazolyl, benzofuranyl, quinolyl, isoquinolyl, imidazopyridyl, or benzopyranyl, \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 91.0
- Lexical Diversity: 1.75
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15305587', '15313407', '15779435', '10583796', '13508905']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8160482547706926
- 35 USC 102 Novelty (BERT): 0.5621340826224563
- Combined Prediction Score: 0.790656837555869
- Mean Citation Score: 322.9079480000001
- Max Citation Score: 436.3854
- Similarity Product: 404.00366363697054

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test