PATENT CLAIM ANALYSIS

Application Number: 16135729
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["546", "273400"]

Abstract:
Described are N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)benzamide and acetamide-containing compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

Claim (Index 18):
The compound of  claim 1 , selected from the group consisting of\n N-(cyclopropylmethyl)-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-3-methoxybenzamide; N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-4-methyl-3-(trifluoromethyl)benzamide; N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-3-methoxy-4-methylbenzamide; N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-3-ethoxybenzamide; N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-3-methoxy-5-methylbenzamide; 2-(3,4-dichlorophenyl)-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)acetamide; 1-acetyl-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)piperidine-3-carboxamide; N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-1-propionylpiperidine-3-carboxamide; N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-1-(3,3,3-trifluoropropanoyl)piperidine-3-carboxamide; N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-1-isobutyrylpiperidine-3-carboxamide; (R)-2-(3,4-dichlorophenyl)-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)acetamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-3-methoxy-4-methylbenzamide; 1-acetyl-N\u2014((R)-6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)piperidine-3-carboxamide; (R)\u2014N-(7-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)-3-methoxy-4-methylbenzamide; (R)-2-(4-chloro-3-fluorophenyl)-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)acetamide; N\u2014((R)-6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-1-propionylpiperidine-3-carboxamide; 1-acetyl-N\u2014((R)-7-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)piperidine-3-carboxamide; N\u2014((R)-7-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)-1-propionylpiperidine-3-carboxamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-6-methoxynicotinamide; (R)-2-chloro-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)isonicotinamide; (R)-2-chloro-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-5-methylnicotinamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-6-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide; (R)-6-chloro-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-4-methylpicolinamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-2-methylisonicotinamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-3-hydroxy-4-methylbenzamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-5-methoxynicotinamide; (R)-3-acetamido-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-4-methylbenzamide; (R)-2-chloro-N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-6-methylnicotinamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-3,5-dimethoxy-4-methylbenzamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-3-fluoroisonicotinamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-6-oxo-1,6-dihydropyridine-3-carboxamide; (R)\u2014N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)-5-fluoronicotinamide; and (R)\u2014N-(1-acetyl-6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1,2,3,4-tetrahydroquinolin-4-yl)-3-methoxy-4-methylbenzamide, or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 97.0
- Lexical Diversity: 1.28947
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15703289', '14206028', '13828285', '14392200', '13548785']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8021144895316469
- 35 USC 102 Novelty (BERT): 0.5577016438423651
- Combined Prediction Score: 0.7776732049627187
- Mean Citation Score: 349.4888620000001
- Max Citation Score: 432.6185
- Similarity Product: 349.20579160162805

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test