PATENT CLAIM ANALYSIS

Application Number: 16238589
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-05
Patent Classification: ["800", "003000"]

Abstract:
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.

Claim (Index 54):
A rodent whose genome comprises a humanized SIRP\u03b1 gene at an endogenous rodent SIRP\u03b1 locus, wherein the humanized SIRP\u03b1 gene\n (i) comprises exon 1 of a rodent SIRP\u03b1 gene, exons 2, 3 and 4 of a human SIRP\u03b1 gene, and exons 5, 6, 7 and 8 of the rodent SIRP\u03b1 gene, \n (ii) is operably linked to a rodent SIRP\u03b1 promoter at the endogenous rodent SIRP\u03b1 locus, and \n (iii) expresses in the rodent a humanized SIRP\u03b1 protein comprising an extracellular portion of the human SIRP\u03b1 protein encoded by the human SIRP\u03b1 gene and an intracellular portion of the rodent SIRP\u03b1 protein encoded by the rodent SIRP\u03b1 gene; and \n wherein the rodent is a rat.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 99.0
- Lexical Diversity: 1.5122
- Patent Class: 800.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14882531', '15263916', '15866632', '14493745', '14516606']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7199487904460445
- 35 USC 102 Novelty (BERT): 0.5803600785056131
- Combined Prediction Score: 0.7059899192520014
- Mean Citation Score: 500.145858
- Max Citation Score: 513.80457
- Similarity Product: 457.56952623542907

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test