PATENT CLAIM ANALYSIS

Application Number: 15754009
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "049000"]

Abstract:
Provided is a preparation method of a composition enriched in compound S p -1. The method performs isomer separation on a reaction product from the first step, and then performs a two-step chemical synthesis, so as to prepare a composition comprising high-purity compound S p -1, wherein the HPLC purity of the single isomer S p -1 is 90% or more. Provided is a composition enriched in compound S p -1. The composition has an inhibitory effect on tumor cell proliferation in vitro significantly higher than that of NUC-1031 and compound R p -1. Also provided are the use of the composition, and a pharmaceutical composition comprising the composition and at least one pharmaceutically acceptable excipient.

Claim (Index 15):
The composition according to  claim 14 , wherein the purity of the compound S p -1 is not less than 97%, and the weight ratio of the compound S p -1 to the compound R p -1 in the composition is not less than 97:3.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 88.0
- Lexical Diversity: 1.8
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15754318', '14970588', '13302409', '12671287', '11110203']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7165378806093237
- 35 USC 102 Novelty (BERT): 0.5237899675828785
- Combined Prediction Score: 0.6972630893066791
- Mean Citation Score: 189.315704
- Max Citation Score: 264.45383
- Similarity Product: 161.2435751622212

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test