PATENT CLAIM ANALYSIS

Application Number: 15867283
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["435", "006100"]

Abstract:
The invention relates to a kit for preparing a library of template polynucleotides suitable for use as templates in solid-phase nucleic acid amplification and sequencing reactions to determine the methylation status of the cytosine bases in the library. In particular, the invention relates to a kit for preparing a library of template polynucleotides suitable for methylation analysis.

Claim (Index 43):
The kit according to  claim 33 , wherein the forked universal adaptors are formed by annealing partially complementary first methylated and second methylated polynucleotide strands, wherein a sequence of 5 or more consecutive nucleotides at 3\u2032 end of the first strand is complementary to a sequence of 5 or more consecutive nucleotides at the 5\u2032 end of the second strand, wherein a duplex region of 5 or more consecutive base pairs is formed by annealing the first and second strands and wherein a sequence of at least 10 consecutive nucleotides at the 5\u2032 end of the first strand and a sequence of at least 10 consecutive nucleotides at the 3\u2032 end of the second strand are not complementary such that a mismatched single stranded region of at least 10 consecutive nucleotides on each strand remains single stranded when the duplex region is annealed.

Metadata:
- Claim Count in Document: 89.0
- Percentile: 86.0
- Lexical Diversity: 1.71429
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12069174', '12799172', '11486953', '15173447', '14022470']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7250491751977329
- 35 USC 102 Novelty (BERT): 0.6835592137208443
- Combined Prediction Score: 0.7209001790500441
- Mean Citation Score: 558.207276
- Max Citation Score: 749.13745
- Similarity Product: 680.512395598495

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test