PATENT CLAIM ANALYSIS

Application Number: 16165267
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["435", "061000"]

Abstract:
The present disclosure describes compositions and methods for rapid selection of both binding and functional oligonucleotides (DNA, RNA, or any natural or synthetic analog of these). In certain embodiments, provided herein are flow cells (e.g., flow cells for an Illumina sequencing instrument or a Polonator sequencing instrument) comprising within its flow chamber a plurality of immobilized aptamer clusters (e.g., from an aptamer library described herein) and, optionally, one or more target cells (e.g., cancer cells, immune cells, etc.) and/or a detectable indicator of cellular function (e.g., a fluorescent indicator of apoptosis, cell proliferation, gene or protein expression, etc.). In certain embodiments, provided herein are methods of using such an aptamer cluster-containing flow cell to identify functional aptamers from an aptamer library (e.g., in a sequencing instrument, such as an Illumina sequencing instrument).

Claim (Index 15):
The method of  claim 13 , further comprising the steps of:\n (a) immobilizing a plurality of aptamers from an aptamer library on a surface; and (b) amplifying the plurality of immobilized aptamers locally on the flow cell surface to form the plurality of immobilized aptamer clusters.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 97.0
- Lexical Diversity: 2.03704
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14647775', '14652728', '12792492', '14801710', '15565667']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5758279265211635
- 35 USC 102 Novelty (BERT): 0.4981057249202017
- Combined Prediction Score: 0.5680557063610674
- Mean Citation Score: 207.20529
- Max Citation Score: 214.5707
- Similarity Product: 133.90201856612563

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test