PATENT CLAIM ANALYSIS

Application Number: 15919866
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "186100"]

Abstract:
Methods for generating antibodies to immuno-subdominant epitopes of elusive pathogens and vaccines and methods of vaccinating subjects against elusive pathogens are disclosed. The methods include targeting immunodominant B cells to undergo apoptosis, for example, while simultaneously targeting the germinal center (GC) reaction toward preferential selection and differentiation of B cells that produce broadly neutralizing antibody against a targeted pathogen.

Claim (Index 14):
The method of  claim 12 , wherein the inhibitory construct is conjugated to an inhibitory molecule that inhibits B cell differentiation into germinal center (GC) B cells, plasma cells or memory B cells to form a peptide-inhibitory-conjugate.

Metadata:
- Claim Count in Document: 45.0
- Percentile: 90.0
- Lexical Diversity: 1.3
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13989176', '13262285', '14777605', '11962007', '15512820']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7762310581661714
- 35 USC 102 Novelty (BERT): 0.5275515965748186
- Combined Prediction Score: 0.7513631120070362
- Mean Citation Score: 315.343366
- Max Citation Score: 333.24872
- Similarity Product: 198.8341214929104

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test