PATENT CLAIM ANALYSIS

Application Number: 16325626
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-07
Patent Classification: ["514", "256000"]

Abstract:
Provided are a phosphodiesterase-4 (PDE4) inhibitor and application thereof in preparation of a medication for treating a disease related to PDE4. Specifically disclosed is a compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.

Claim (Index 1):
A compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, wherein, X is O or N(R 2 ); R 2  is H, F, Cl, Br, I, OH, NH 2  or R 3 -L 1 -, or selected from the group consisting of C 1-6  alkyl, C 1-6  heteroalkyl, C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R; R 3  is selected from the group consisting of C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R; L 1  is selected from the group consisting of \u2014CH 2 \u2014, \u2014CH 2 CH 2 \u2014, O, S, NH and \u2014C(\u2550O)\u2014; n is selected from the group consisting of 1, 2 and 3; R 1  is selected from H, F, Cl, Br, I, OH, NH 2 , COOH, R 4 -L 2 -, or selected from the group consisting of C 1-6  alkyl, C 1-6  heteroalkyl, C 2-6  alkenyl, C 3-6  cycloalkenyl, 3-6 membered heterocycloalkenyl, C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R; R 4  is selected from the group consisting of C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl, 3-6 membered heterocycloalkenyl, phenyl and 5-6 membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R; L 2  is selected from the group consisting of \u2014CH 2 \u2014, \u2014CH 2 CH 2 \u2014, O, S, NH, \u2014C(\u2550O)NH\u2014, \u2014C(\u2550O)O\u2014 and \u2014C(\u2550O)\u2014; R is selected from H, halogen, OH, NH 2 , CN, or selected from the group consisting of C 1-6  alkyl, C 1-6  heteroalkyl, C 3-6  cycloalkyl, 3-6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2 or 3 R; R\u2032 is selected from the group consisting of H, F, Cl, Br, I, OH, CN, NH 2 , Me, Et, CF 3 , CHF 2 , CH 2 F, NHCH 3  and N(CH 3 ) 2 ; the \u201chetero\u201d in the C 1-6  heteroalkyl, 3-6 membered heterocycloalkyl, 5-6 membered heteroaryl and 3-6 membered heterocycloalkenyl is selected from \u2014C(\u2550O)NH\u2014, \u2014NH\u2014, \u2014C(\u2550NH)\u2014, \u2014S(\u2550O) 2 NH\u2014, \u2014S(\u2550O)NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2550O, \u2550S, \u2014O\u2014N\u2550, \u2014C(\u2550O)O\u2014, \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, \u2014S(\u2550O\u2014, \u2014S(\u2550O) 2 \u2014 and \u2014NHC(\u2550O)NH\u2014; in any of the above cases, the number of the heteroatom or the heteroatom group is independently selected from 1, 2 or 3.

Metadata:
- Claim Count in Document: 62.0
- Percentile: 99.0
- Lexical Diversity: 1.34375
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16326976', '15314599', '16317510', '15128064', '15812142']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8133849349533183
- 35 USC 102 Novelty (BERT): 0.547543580977248
- Combined Prediction Score: 0.7868007995557112
- Mean Citation Score: 379.939528
- Max Citation Score: 390.95236
- Similarity Product: 355.67789833908563

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test