PATENT CLAIM ANALYSIS

Application Number: 16321020
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-06
Patent Classification: ["424", "133100"]

Abstract:
The present invention relates to an antigen-binding protein, preferably a monoclonal antibody, against annexin A2 (ANXA2), comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence GYSITSGYSWH, a VHCDR2 of sequence YIHYSGSTKYNPSLKS and a VHCDR3 of sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSNDQKNYLA, a VLCDR2 of sequence WASIRES, and a VLCDR3 of sequence QQYYIYPLT. Also provided is an ANXA2 binding protein comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence VYSITSGYSWH; a VHCDR2 of sequence YIHYSGSTKYNPSLKS, and a VHCDR3 of sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSSNQKNYLA, a VLCDR2 of sequence WASSRES, and a VLCDR3 of sequence QQYYIYPLT. The antibodies preferably bind to an N-linked glycan on ANXA2, and are internalised upon binding. They may be conjugated with cytotoxins and may be used in the treatment or detection of cancer.

Claim (Index 70):
The antigen-binding protein, or antigen-binding fragment thereof, as claimed in  claim 67 , wherein the light chain variable region of (a) comprises the nucleic acid sequence set forth in SEQ ID NO:4, or wherein the light chain variable region of (b) comprises the nucleic acid sequence set forth in SEQ ID NO: 8; optionally wherein the light chain variable region comprises a nucleic acid sequence having about 60%, 65%, 70%, 75%, 80%, about 85%, about 90%, about 95%, about 96%, about 97%, about 98% or about 99% identity to the amino acid sequence set forth in SEQ ID NO:4 or SEQ ID NO: 8,

Metadata:
- Claim Count in Document: 32.0
- Percentile: 99.0
- Lexical Diversity: 2.43836
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13571151', '14789612', '14080249', '14800429', '15317355']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7715786156590341
- 35 USC 102 Novelty (BERT): 0.5608665820099846
- Combined Prediction Score: 0.7505074122941291
- Mean Citation Score: 446.56904
- Max Citation Score: 456.6566
- Similarity Product: 303.0479749180794

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test