PATENT CLAIM ANALYSIS

Application Number: 15743546
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["546", "153000"]

Abstract:
Compounds that inhibit Myeloid Cell Leukemia-1 (Mcl-1) oncoprotein, and methods of using the same, are provided for treating disease.

Claim (Index 5):
The compound of  claim 4 , wherein the compound is selected from the group consisting of 4-(N-(4-(4-chloro-3,5-dimethyl phenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid,\n 4-(N-(4-(4-chloro-3,5-dimethylphenoxy)phenyl)-N-isobutylsulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(4-(4-chloro-3,5-dimethylphenoxy)phenyl)-N-cyclopentylsulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-benzyl-N-(4-(4-chloro-3,5-dimethylphenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-benzylsulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(4-chlorophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(3-chlorobenzyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-(trifluoromethyl)phenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(2-chlorobenzyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(p-tolyl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(4-isopropylphenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(3-cyanophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-([1,1\u2032-biphenyl]-2-yl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-([1,1\u2032-biphenyl]-4-yl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-([1,1\u2032-biphenyl]-3-yl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-((4-phenylpiperazin-1-yl)sulfonyl)-2-naphthoic acid, 1-hydroxy-4-(N-(naphthalen-1-yl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(naphthalen-2-yl)sulfamoyl)-2-naphthoic acid, 4-(N-(4-cyanophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-methoxyphenyl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(2-(trifluoromethyl)phenyl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(4-nitrophenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(2-bromophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(3-bromophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(cyclohexylmethyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, methyl 4-(N-(4-bromophenyl)-N-isobutylsulfamoyl)-1-methoxy-2-naphthoate, methyl 4-(N-(4-bromophenyl)-N-isobutylsulfamoyl)-1-hydroxy-2-naphthoate, 4-(N-(4-bromophenyl)-N-isobutylsulfamoyl)-1-methoxy-2-naphthoic acid, 1-hydroxy-4-(piperidin-1-ylsulfonyl)-2-naphthoic acid, 4-(N-(4-chlorobenzyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(2,4-dibromophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-isopropoxyphenyl)sulfamoyl)-2-naphthoic acid, 1-hydroxy-4-(N-(4-(naphthalen-1-yloxy)phenyl)sulfamoyl)-2-naphthoic acid, 4-(N,N-dimethylsulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-phenoxyphenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(4-(3-bromophenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-(4-(p-tolyloxy)phenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(4-(2,4-dichlorophenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-((4-benzylpiperazin-1-yl)sulfonyl)-1-hydroxy-2-naphthoic acid, 4-(N-(4-(4-chlorophenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 4-(N-(4-(3,5-dimethylphenoxy)phenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-(N-phenylsulfamoyl)-2-naphthoic acid, 4-(N-(4-bromophenyl)-N-isobutylsulfamoyl)-1-hydroxy-2-naphthoic acid, 1-hydroxy-4-sulfamoyl-2-naphthoic acid, 1-hydroxy-4-(N-isobutyl-N-(4-isopropoxyphenyl)sulfamoyl)-2-naphthoic acid, 4-(N-(4-bromophenyl)sulfamoyl)-1-hydroxy-2-naphthoic acid, methyl 1-hydroxy-4-(N-isobutyl-N-(4-isopropoxyphenyl)sulfamoyl)-2-naphthoate, acetoxymethyl 1-hydroxy-4-(N-isobutyl-N-(4-isopropoxyphenyl)sulfamoyl)-2-naphthoate, and the pharmaceutically acceptable salts, solvates, hydrates, cocrystals, or prodrugs thereof.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 86.0
- Lexical Diversity: 1.04348
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12104294', '12096393', '14763468', '13823810', '13526337']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7884681480315531
- 35 USC 102 Novelty (BERT): 0.5078988583167052
- Combined Prediction Score: 0.7604112190600684
- Mean Citation Score: 268.77087199999994
- Max Citation Score: 276.15472
- Similarity Product: 206.4315301155281

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test