PATENT CLAIM ANALYSIS

Application Number: 16244796
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-07
Patent Classification: ["544", "343000"]

Abstract:
The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines

Claim (Index 190):
A method for preparing a Compound of Formula 2F: or a pharmaceutically acceptable salt thereof, wherein: (i) k is 1; (ii) m is 1; (iii) n is 1; (iv) B is benzyl or triphenylmethyl, or is a moiety of the formula: wherein: a) Z is C 1-6  alkyl, aryl, C 1-6  alkylaryl or \u2014OR wherein R is C 1-6  alkyl, aryl, arylC 1-6 alkyl or heteroarylC 1-6  alkyl; b) P is \u2014C(O)\u2014, \u2014C(O)O\u2014 or \u2014S(O) 2 \u2014; (v) R 5  is H; (vi) R 7 , R 8  and R 9  are H; and (vii) X\u2014Y\u2014 is a \u2014(R\u2032)N\u2014CH 2 \u2014 or \u2014(R\u2032)N\u2014C(O)\u2014, wherein R\u2032 is H or methyl; comprising the step of reacting a Compound of Formula 2E: wherein: (i) k is 1; (ii) m is 1; (iii) n is 1; (iv) A is Cl, Br, F or I; (v) B is benzyl or triphenylmethyl, or is a moiety of the formula: wherein: c) Z is C 1-6  alkyl, aryl, C 1-6  alkylaryl or \u2014OR wherein R is C 1-6  alkyl, aryl, arylC 1-6 alkyl or heteroarylC 1-6  alkyl; d) P is \u2014C(O)\u2014, \u2014C(O)O\u2014 or \u2014S(O) 2 \u2014; (vi) R 5  is H; (vii) R 7 , R 8  and R 9  are H; and (viii) X\u2014Y\u2014 is a H(R\u2032)N\u2014CH 2 \u2014 or H(R\u2032)N\u2014C(O)\u2014, wherein R\u2032 is H or methyl;\n with (a) a transition metal catalyst, and (b) a base, to form the compound of Formula 2F; \n wherein the transition metal catalyst is selected from the group consisting of palladium, copper, nickel, platinum, ruthenium and rhodium catalysts.

Metadata:
- Claim Count in Document: 31.0
- Percentile: 99.0
- Lexical Diversity: 1.42857
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15660762', '12531016', '15066962', '13593097', '14323545']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8211163135418111
- 35 USC 102 Novelty (BERT): 0.603957480467334
- Combined Prediction Score: 0.7994004302343635
- Mean Citation Score: 529.863172
- Max Citation Score: 548.28394
- Similarity Product: 481.9336790793025

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test