PATENT CLAIM ANALYSIS

Application Number: 15892331
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "093710"]

Abstract:
The present disclosure provides methods for re-stimulating TIL populations that lead to improved phenotype and increased metabolic health of the TILs and provides methods of assaying for TIL populations to determine suitability for more efficacious infusion after re-stimulation.

Claim (Index 1):
A method for treating a subject with head and neck cancer comprising administering expanded tumor infiltrating lymphocytes (TILs) comprising:\n (i) obtaining a first population of TILs from a tumor resected from a subject; (ii) performing a first expansion by culturing the first population of TILs in a cell culture medium comprising IL-2 to produce a second population of TILs; (iii) performing a second expansion by supplementing the cell culture medium of the second population of TILs with additional IL-2, OKT-3, and antigen presenting cells (APCs), to produce a third population of TILs, wherein the third population of TILs is at least 100-fold greater in number than the second population of TILs, and wherein the second expansion is performed for at least 14 days in order to obtain the third population of TILs, wherein the third population of TILs is a therapeutic population of TILs which comprises an increased subpopulation of effector T cells and/or central memory T cells relative to the second population of TILs; and (iv) administering a therapeutically effective dosage of the third population of TILs to the subject.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 88.0
- Lexical Diversity: 1.3
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15892311', '15874718', '15800967', '14917214', '15110111']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7489093032610366
- 35 USC 102 Novelty (BERT): 0.6002787222115877
- Combined Prediction Score: 0.7340462451560917
- Mean Citation Score: 395.835198
- Max Citation Score: 565.9608
- Similarity Product: 458.7718290438652

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test