PATENT CLAIM ANALYSIS

Application Number: 15998791
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["546", "212000"]

Abstract:
The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.

Claim (Index 12):
A method for preparing a 2,3,5-substituted thiophene compound, the method comprising:\n (Step A) preparing a compound of Formula 7, in which an acetylene group is introduced into a C5 position of thiophene by allowing 2-(Boc protected carboxamido)-3-amino-5-bromo-thiophene compound of Formula 2 to react with an acetylene compound of Formula 11, wherein, R 1 , R 2 , A, and n are the same as those defined in  claim 1 , and Boc is a tert-butoxycarbonyl group; (Step B) preparing a compound of Formula 9 by allowing a compound of Formula 7 to react with the trichloroacetyl isocyanate of Formula 8, wherein, R 1 , R 2 , A, and n are the same as those defined in  claim 1 , and Boc is a tert-butoxycarbonyl group; (Step C) preparing a compound of Formula 10 by removing a trichloroacetyl (F 3 CC(O)\u2014) group from a compound of Formula 9, wherein, Z, R 1 , R 2 , A, and n are the same as those defined in  claim 1 , and Boc is a tert-butoxycarbonyl group; and (Step D) preparing a compound of Formula 1a by desorbing a tert-butoxycarbonyl (Boc) group from a compound of Formula 10. wherein, Z, R 1 , R 2 , A, and n are the same as those defined in  claim 1 , and Boc is a tert-butoxycarbonyl group.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.2069
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15370631', '14153891', '13834316', '13980182', '13080762']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.776305204537032
- 35 USC 102 Novelty (BERT): 0.5084571896020244
- Combined Prediction Score: 0.7495204030435312
- Mean Citation Score: 258.022286
- Max Citation Score: 262.91245
- Similarity Product: 161.65962960131168

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test