PATENT CLAIM ANALYSIS

Application Number: 16198134
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["548", "400000"]

Abstract:
The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R 1 —H which comprises a first functional moiety of formula F 1  to a second functional moiety of formula F 2 wherein X, X′, Y, R 1 , F 1  and F 2  are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.

Claim (Index 57):
A compound of formula (III) wherein:\n R 1  is a group of formula \u2014F 1  or \u2014S-L-F 1 , wherein R 1 \u2014H comprises at least a first thiol group SH, said first thiol group being attached to the 2-position in the compound of formula (III) by loss of its hydrogen atom; \n R 2a  represents a group of formula Y, Nu, -L(Z) n , IG, F 2  or -L(F 2 ) m (Z) n-m ; \n each R 33a\u2032  is the same or different and represents a hydrogen atom or a group of formula Y, Nu, -L(Z) n , IG, F 2  or -L(F 2 ) m (Z) n-m ; \n F 1  is a first functional moiety and F 2  is a second functional moiety, wherein the compound of formula (III) comprises at least one group of formula F 2 ; \n each group of formula Y is the same or different and represents an electrophilic leaving group; \n each group of formula Nu is the same or different and represents a nucleophile selected from \u2014OH, \u2014SH, \u2014NH 2  and \u2014NH(C 1-6  alkyl); \n each group of formula L is the same or different and represents a linker group; \n each group of formula Z is the same or different and represents a reactive group attached to a group of formula L which is capable of reacting with a compound containing a second functional moiety such that said second functional moiety becomes linked to said group of formula L; \n n is 1, 2 or 3; \n each group of formula IG is the same or different and represents a moiety which is a C 1-20  alkyl group, a C 2-20  alkenyl group or a C 2-20  alkynyl group, which is unsubstituted or substituted by one or more substituents selected from halogen atoms and sulfonic acid groups, and in which (a) 0, 1 or 2 carbon atoms are replaced by groups selected from C 6-10  arylene, 5- to 10-membered heteroarylene, C 3-7  carbocyclylene and 5- to 10-membered heterocyclylene groups, and (b) 0, 1 or 2 \u2014CH 2 \u2014 groups are replaced by groups selected from \u2014O\u2014, \u2014S\u2014, \u2014S\u2014S\u2014, \u2014C(O)\u2014 and \u2014N(C 1-6  alkyl)- groups, wherein: \n (i) said arylene, heteroarylene, carbocyclylene and heterocyclylene groups are unsubstituted or substituted by one or more substituents selected from halogen atoms and C 1-6  alkyl, C 1-6  alkoxy, C 1-6  alkylthiol, \u2014N(C 1-6  alkyl)(C 1-6  alkyl), nitro and sulfonic acid groups; and \n (ii) 0, 1 or 2 carbon atoms in said carbocyclylene and heterocyclylene groups are replaced by \u2014C(O)\u2014 groups; and \n m is an integer having a value of from zero to n.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 98.0
- Lexical Diversity: 1.7541
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['13389625', '15045906', '14378138', '12280683', '13725382']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7254112020503167
- 35 USC 102 Novelty (BERT): 0.6637006891390662
- Combined Prediction Score: 0.7192401507591917
- Mean Citation Score: 426.989938
- Max Citation Score: 752.02435
- Similarity Product: 592.5316178400398

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test