PATENT CLAIM ANALYSIS

Application Number: 15770138
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["514", "394000"]

Abstract:
The invention provides a pharmaceutical composition for injection comprising a NL-101 type compound and a preparation method thereof. The composition uses the NL-101 type compound as an active pharmaceutical ingredient, and the stability of the NL-101 type compound is improved by adding a chloride-containing stabilizing agent or using a co-solvent containing hydrochloric acid, so that the formulation can be stably produced and meet the requirements for clinical safe use.

Claim (Index 9):
The pharmaceutical composition according to  claim 8 , characterized in further comprising a lyophilizing protectant, a pH controlling agent, and water for injection;\n preferably, the lyophilizing protectant is a pharmaceutically acceptable cyclic polysaccharide or a mixture thereof, preferably the cyclic polysaccharide is cyclodextrin, cyclomannin, cycloaltrin, cyclofructin or an analog thereof, further preferably the cyclic polysaccharide is cyclodextrin or a derivative thereof, further preferably the cyclic polysaccharide is \u03b1-cyclodextrin or a derivative thereof, \u03b2-cyclodextrin or a derivative thereof, or \u03b3-cyclodextrin or a derivative thereof, further preferably the cyclic polysaccharide is \u03b2-cyclodextrin or a derivative thereof, most preferably the cyclic polysaccharide is \u03b2-cyclodextrin, sulfobutylether-\u03b2-cyclodextrin and/or hydroxypropyl-\u03b2-cyclodextrin; preferably, the pH controlling agent is a mixture selected from one or more of sodium hydroxide, sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, sodium citrate, and potassium citrate, and further preferably is sodium hydroxide; preferably, the pharmaceutical composition further comprises a stabilizing agent, further preferably, the stabilizing agent is a mixture selected from one or more of sodium chloride, potassium chloride, and hydrochloric acid, and still further preferably is sodium chloride.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 91.0
- Lexical Diversity: 1.43137
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14345562', '13746999', '12762025', '14538464', '14030692']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7505795930025215
- 35 USC 102 Novelty (BERT): 0.5087228037211643
- Combined Prediction Score: 0.7263939140743858
- Mean Citation Score: 226.71752
- Max Citation Score: 266.564
- Similarity Product: 180.18344079208373

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test