PATENT CLAIM ANALYSIS

Application Number: 16098546
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-05
Patent Classification: ["514", "235500"]

Abstract:
This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein which exhibit strong inhibition effects on various cancer cell lines. The compounds disclosed herein are useful for the treatment of proliferative diseases, including neoplastic diseases such as cancer and non-neoplastic disorders such as rheumatoid arthritis. Also disclosed are pharmaceutical compositions containing compounds of Formula I and at least one carrier, diluent or excipient and optionally one or more additional therapeutically active agents, including anticancer agents. This application also discloses methods for treating a proliferative disease, including neoplastic diseases such as cancer and non-neoplastic disorders such as rheumatoid arthritis.

Claim (Index 52):
A compound having a structure represented by formula (I): wherein\n L 1  is a single bond, or substituted or unsubstituted alkylene, substituted or unsubstituted alkenylene, or substituted or unsubstituted alkynylene; \n L 2  is a single bond or carbonyl; \n R 1  is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; \n R 2  is hydroxyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted alkoxycarbonylamino, substituted or unsubstituted aryloxycarbonylamino, substituted or unsubstituted heteroaryloxycarbonylamino, substituted or unsubstituted alkylaminocarbonylamino, substituted or unsubstituted arylaminocarbonylamino, substituted or unsubstituted heteroarylaminocarbonylamino, or NR 5 R 6  wherein each R 5  and R 6  is independently H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocycloalkyl; \n Q 1 , Q 2 , Q 3  and Q 4  are each independently H, hydroxyl, halo, amino, nitro, thiol, carboxyl, cyano, azido, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted sulfanyl, substituted or unsubstituted alkylamino, substituted or unsubstituted dialkylamino, substituted or unsubstituted arylamino, substituted or unsubstituted heteroarylamino, substituted or unsubstituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted aminocarbonyl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, substituted sulfo, substituted sulfonyl, substituted sulfinyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted sulfonylamino, substituted or unsubstituted aminocarbonylamino, substituted or unsubstituted aminocarbonyloxy, substituted or unsubstituted alkoxycarbonylamino, substituted or unsubstituted aryloxycarbonylamino, or substituted or unsubstituted heteroaryloxycarbonylamino; \n R 3a  is halo, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, or substituted or unsubstituted aminocarbonyl; \n each R 3b  is independently H, hydroxyl, halo, azido, amino, nitro, thiol, cyano, carboxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocycloalkyl; \n R 3c  is H; \n W is optionally present and if present is H, hydroxyl, halo, azido, amino, nitro, thiol, cyano, carboxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted sulfanyl, substituted or unsubstituted alkylamino, substituted or unsubstituted dialkylamino, substituted or unsubstituted arylamino, substituted or unsubstituted heteroarylamino, substituted or unsubstituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted aminocarbonyl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, substituted sulfo, substituted sulfonyl, substituted sulfinyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted sulfonylamino, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted aminocarbonylamino, substituted or unsubstituted aminocarbonyloxy, substituted or unsubstituted alkoxycarbonylamino, substituted or unsubstituted aryloxycarbonylamino, or substituted or unsubstituted heteroaryloxycarbonylamino; \n m is 0, 1, 2, 3, or 4; \n if m is 0, then d is independently 0, 1 or 2; if m is 1, then d is independently 0, 1, 2 or 3; if m is 2, then d is independently 0, 1, 2, 3 or 4; if m is 3, then d is independently 0, 1, 2, 3, 4 or 5 or if m is 4 then d is independently 0, 1, 2, 3, 4, 5 or 6; or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, or an isotopic variant, tautomer, or stereoisomer thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 98.0
- Lexical Diversity: 1.62857
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15526983', '14777917', '14777459', '14410426', '14758194']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7611437550851419
- 35 USC 102 Novelty (BERT): 0.5292048936250474
- Combined Prediction Score: 0.7379498689391324
- Mean Citation Score: 295.124112
- Max Citation Score: 323.60352
- Similarity Product: 238.12181021421432

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test