PATENT CLAIM ANALYSIS

Application Number: 15978670
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "04400A"]

Abstract:
The invention relates to a saRNAs useful in upregulating the expression of a target gene and therapeutic compositions comprising the saRNA. Methods of using the saRNA and the therapeutic compositions are also provided.

Claim (Index 1):
A synthetic isolated saRNA which comprises a strand that targets a region between 2000 nucleotides upstream and 2000 nucleotides downstream of the transcription start site (TSS core) of a target gene,\n wherein the strand is 14-30 nucleotides in length, and wherein the target gene has a sequence selected from the group consisting of SEQ ID NO: 1 (APOA1), SEQ ID NO: 2 (APOA1), SEQ ID NO: 3 (APOA1), SEQ ID NO: 4 (LDLR), SEQ ID NO: 5 (LDLR), SEQ ID NO: 6 (LDLR), SEQ ID NO: 13 (DMD), SEQ ID NO: 14 (DMD), SEQ ID NO: 15 (DMD), SEQ ID NO: 16 (DMD), SEQ ID NO: 17 (DMD), SEQ ID NO: 18 (DMD), SEQ ID NO: 19 (DMD), SEQ ID NO: 20 (PAX5), SEQ ID NO: 21 (SCN1A), SEQ ID NO: 22 (SCN1A), SEQ ID NO: 23 (IDUA), SEQ ID NO: 24 (FNDC5), SEQ ID NO: 25 (FNDC5), SEQ ID NO: 26 (FOXA2), SEQ ID NO: 27 (FOXA2), SEQ ID NO: 28 (FOXP3), SEQ ID NO: 29 (HNF4A), SEQ ID NO: 30 (HNF4A), SEQ ID NO: 31 (IFNG), SEQ ID NO: 32 (IL10), SEQ ID NO: 33 (IL2), SEQ ID NO: 34 (IL19), SEQ ID NO: 35 (LMX1A), SEQ ID NO: 36 (LMX1A), SEQ ID NO: 37 (METRNL), SEQ ID NO: 38 (NR4A2), SEQ ID NO: 39 (SIRT1), SEQ ID NO: 40 (TH), SEQ ID NO: 41 (EPO), SEQ ID NO: 42 (CDKN1B), SEQ ID NO: 43 (MDM2), SEQ ID NO: 44 (MDM2), SEQ ID NO: 45 (C19orf80), SEQ ID NO: 46 (F7), SEQ ID NO: 47 (F8) and SEQ ID NO: 48 (F8).

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.4
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13877968', '13096817', '15038332', '11910722', '14504303']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7645494835787601
- 35 USC 102 Novelty (BERT): 0.5122073685882785
- Combined Prediction Score: 0.7393152720797119
- Mean Citation Score: 239.24641000000005
- Max Citation Score: 247.44456
- Similarity Product: 162.25298887561797

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test