PATENT CLAIM ANALYSIS

Application Number: 16069326
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["546", "156000"]

Abstract:
Compounds of the formula I in which X 1 , X 2 , X 3 , X 4 , R 1 , R 2 , R 3 , Q and Y have the meanings indicated in Claim  1,  are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.

Claim (Index 7):
Compounds according to  claim 1 , selected from the group No. Name \u201cA1\u201d 6-fluoro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA2\u201d 3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}- 1H-quinolin-2-one \u201cA3\u201d N,N-dimethyl-4-[4-(2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl)- [1,2,3]triazol-1-yl]-benzamide \u201cA4\u201d N,N-dimethyl-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl]-benzamide \u201cA5\u201d 3-[1-(4-dimethylaminomethyl-phenyl)-1H-[1,2,3]triazol-4-yl]-1H- [1,8]naphthyridin-2-one \u201cA6\u201d 3-(1-phenyl-1H-[1,2,3]triazol-4-yl)-1H-[1,8]naphthyridin-2-one \u201cA7\u201d 3-[1-(4-hydroxymethyl-phenyl)-1H-[1,2,3]triazol-4-yl]-1H- [1,8]naphthyridin-2-one \u201cA8\u201d N-(2-hydroxy-ethyl)-4-[4-(2-oxo-1,2-dihydro-[1,8]naphthyridin-3- yl)-[1,2,3]triazol-1-yl]-benzamide \u201cA9\u201d N-(2-methoxy-ethyl)-4-[4-(2-oxo-1,2-dihydro-[1,8]naphthyridin-3- yl)-[1,2,3]triazol-1-yl]-benzamide \u201cA10\u201d 3-[1-(4-methoxy-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA11\u201d 4-[4-(6-chloro-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl)- [1,2,3]triazol-1-yl]-N,N-dimethyl-benzamide \u201cA12\u201d 3-[1-(4-fluoro-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA13\u201d 3-[1-(2-fluoro-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA14\u201d 3-{1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl}- 1H-quinolin-2-one \u201cA15\u201d N-(1-methyl-piperidin-4-ylmethyl)-4-[4-(2-oxo-1,2-dihydro- quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide \u201cA16\u201d 4-[4-(6-methoxy-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl)- [1,2,3]triazol-1-yl]-N,N-dimethyl-benzamide \u201cA17\u201d 4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-pyridine- 2-carboxylic acid methyl ester \u201cA18\u201d 4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]- N,N-dimethyl-benzamide \u201cA19\u201d N-(2-hydroxy-ethyl)-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzamide \u201cA20\u201d 3-[1-(1H-indo1-5-yl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA21\u201d N-(2-morpholin-4-yl-ethyl)-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzamide \u201cA22\u201d 4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]- N-(1-methyl-piperidin-4-ylmethyl)-benzamide \u201cA23\u201d 3-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzoic acid methyl ester \u201cA24\u201d 3-[1-(3-methoxy-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA25\u201d 3-{1-[4-(3-oxo-morpholin-4-yl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H- quinolin-2-one \u201cA26\u201d 3-{1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl}- 1H-quinolin-2-one \u201cA27\u201d 3-(1-phenyl-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA28\u201d 3-[1-(3H-benzimidazol-5-yl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA29\u201d 3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}- 1H-[1,7]naphthyridin-2-one \u201cA30\u201d 7-methyl-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-[1,8]naphthyridin-2-one \u201cA31\u201d 6-fluoro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-[1,8]naphthyridin-2-one \u201cA32\u201d 3-{1-[3-fluoro-4-(3-oxo-morpholin-4-yl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA33\u201d 6-fluoro-3-{1-[3-fluoro-4-(3-oxo-morpholin-4-yl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA34\u201d 3-{1-[6-(3-oxo-morpholin-4-yl)-pyridin-3-yl]-1H-[1,2,3]triazol-4- yl}-1H-quinolin-2-one \u201cA35\u201d 3-{1-[2-methyl-4-(morpholine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA36\u201d 3-{1-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-1H-[1,2,3]triazol-4-yl}- 1H-quinolin-2-one \u201cA37\u201d 3-{1-[3-fluoro-4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA38\u201d 3-[1-(3,4,5-trimethoxy-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA39\u201d 2-fluoro-N-methyl-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzamide \u201cA40\u201d 3-{1-[3-methyl-4-(morpholine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA41\u201d 3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}- 1H-[1,6]naphthyridin-2-one \u201cA42\u201d N,N-dimethyl-4-[4-(2-oxo-1,2-dihydro-[1,7]naphthyridin-3-yl)- [1,2,3]triazol-1-yl]-benzamide \u201cA43\u201d 3-(1-phenyl-1H-pyrazol-4-yl)-1H-[1,8]naphthyridin-2-one \u201cA44\u201d 3-(1-phenyl-1H-pyrazol-4-yl)-1H-[1,7]naphthyridin-2-one \u201cA45\u201d 3-[1-(4-fluoro-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-[1,6]naphthyridin- 2-one \u201cA46\u201d 3-(1-phenyl-1H-pyrazol-4-yl)-1H-[1,6]naphthyridin-2-one \u201cA47\u201d 3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}- 1H-[1,8]naphthyridin-2-one \u201cA48\u201d 5-fluoro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA49\u201d 3-{1-[4-(3-oxo-morpholin-4-yl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H- [1,7]naphthyridin-2-one \u201cA50\u201d 3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H- quinolin-2-one \u201cA51\u201d 4-[4-(2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl)-[1,2,3]triazol-1-yl]- N-piperidin-4-yl-benzamide \u201cA52\u201d 3-[1-(4-piperazin-1-yl-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA53\u201d 6-fluoro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA54\u201d 3-[1-(2-piperazin-1-yl-pyrimidin-5-yl)-1H-[1,2,3]triazol-4-yl]-1H- quinolin-2-one \u201cA55\u201d 3-[1-(4-[1,4]diazepan-1-yl-phenyl)-1H-[1,2,3]triazol-4-yl]-1H- quinolin-2-one \u201cA56\u201d 6-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA57\u201d 3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA58\u201d N-(1-Methyl-piperidin-4-yl)-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzamide \u201cA59\u201d N-methyl-N-(1-methyl-piperidin-4-yl)-4-[4-(2-oxo-1,2-dihydro- quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide \u201cA60\u201d 3-{1-[4-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA61\u201d 3-{1-[4-(4-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA62\u201d 3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-[1,6]naphthyridin-2-one \u201cA63\u201d 3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-[1,7]naphthyridin-2-one \u201cA64\u201d 3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-[1,8]naphthyridin-2-one \u201cA65\u201d 7-methyl-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-[1,8]naphthyridin-2-one \u201cA66\u201d 3-{1-[2-(4-methyl-piperazin-1-yl)-pyrimidin-5-yl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA67\u201d 6-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-[1,8]naphthyridin-2-one \u201cA68\u201d 3-{1-[4-(4-methyl-2-oxo-piperazin-1-yl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA69\u201d 3-{1-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-1H-[1,2,3]triazol-4- yl}-1H-quinolin-2-one \u201cA70\u201d 6-fluoro-3-{1-[4-(4-methyl-piperazin-1-yl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA71\u201d 6-fluoro-3-{1-[4-(4-methyl-2-oxo-piperazin-1-yl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA72\u201d 3-(1-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenyl}-1H- [1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA73\u201d 3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl}-1H- quinolin-2-one \u201cA74\u201d 3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl}- 1H-quinolin-2-one \u201cA75\u201d 3-(1-phenyl-1H-pyrazol-4-yl)-1H-quinolin-2-one \u201cA76\u201d 3-{1-[3-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}- 1H-quinolin-2-one \u201cA77\u201d 4-[4-(2-Oxo-1,2-dihydro-[1,8]naphthyridin-3-yl)-[1,2,3]triazol-1-yl]- benzoic acid \u201cA78\u201d 3-{1-[3-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H- quinolin-2-one \u201cA79\u201d 3-{1-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA80\u201d 3-[1-(4-isopropenyl-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA81\u201d 3-{1-[4-(1-methanesulfonyl-1-methyl-ethyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA82\u201d 7-chloro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA83\u201d 7-fluoro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA84\u201d 7-methyl-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA85\u201d 3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}- 1H-[1,5]naphthyridin-2-one \u201cA86\u201d 6-fluoro-3-(1-{4-[4-(3-methoxy-propyl)-piperazine-1-carbonyl]- phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA87\u201d 5-fluoro-3-(1-{4-[4-(3-methoxy-propyl)-piperazine-1-carbonyl]- phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA88\u201d 6-fluoro-3-(1-{4-[4-(3-methoxy-propyl)-piperazine-1-carbonyl]- phenyl}-1H-[1,2,3]triazol-4-yl)-1H-[1,8]naphthyridin-2-one \u201cA89\u201d 3-(1-{4-[4-(3-methoxy-propyl)-piperazine-1-carbonyl]-phenyl}-1H- [1,2,3]triazol-4-yl)-1H-[1,8]naphthyridin-2-one \u201cA90\u201d 5,7-difluoro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA91\u201d 7-bromo-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA92\u201d 6-fluoro-3-{1-[4-(4-methyl-3-oxo-piperazine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA93\u201d 7-methoxy-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA94\u201d 6-{1-[4-(Morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}- 8H-pyrido[2,3-d]pyrimidin-7-one \u201cA94a\u201d 6-fluoro-3-{1-[3-(2-morpholin-4-yl-ethoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA95\u201d 5,7-difluoro-3-{1-[4-(4-methyl-3-oxo-piperazine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA96\u201d 6-chloro-3-{1-[4-(4-methyl-3-oxo-piperazine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA97\u201d 7-chloro-3-{1-[4-(4-methyl-3-oxo-piperazine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA98\u201d 6-fluoro-3-{1-[4-(2-oxo-oxazolidin-3-yl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA99\u201d 3-{1-[4-(1,1-dioxo-1l6-isothiazolidin-2-yl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA100\u201d 3-{1-[4-([1,3\u2032]bipyrrolidinyl-1\u2032-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-6-fluoro-1H-quinolin-2-one \u201cA100a\u201d 3-(1-{4-[2-(4-acetyl-piperazin-1-yl)-ethoxy]-phenyl}-1H- [1,2,3]triazol-4-yl)-6-fluoro-1H-quinolin-2-one \u201cA101\u201d 3-(1-{4-[2-(4-acetyl-piperazin-1-yl)-ethoxy]-phenyl}-1H- [1,2,3]triazol-4-yl)-6,7-difluoro-1H-quinolin-2-one \u201cA102\u201d acetic acid 1-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzoyl}-piperidin-4-yl ester \u201cA103\u201d acetic acid 1-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzoyl}-piperidin-3-yl ester \u201cA104\u201d 3-{1-[4-([1,3\u2032]bipyrrolidinyl-1\u2032-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA105\u201d 3-{1-[4-([1,3\u2032]bipyrrolidinyl-1\u2032-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-5,7-difluoro-1H-quinolin-2-one \u201cA106\u201d 6-fluoro-3-{1-[4-(3-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA107\u201d 3-{1-[3-([1,3\u2032]bipyrrolidinyl-1\u2032-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-6-fluoro-1H-quinolin-2-one \u201cA108\u201d 3-{1-[3-([1,3\u2032]bipyrrolidinyl-1\u2032-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA109\u201d 6,7-difluoro-3-{1-[4-(3-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA110\u201d 6-fluoro-3-{1-[4-(4-methyl-5-oxo-[1,4]diazepane-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA111\u201d 6-fluoro-3-{1-[4-((R)-3-methoxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA112\u201d 6-fluoro-3-{1-[4-((S)-3-methoxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA113\u201d 6,7-difluoro-3-{1-[4-((R)-3-methoxy-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA114\u201d 6,7-difluoro-3-{1-[4-((S)-3-methoxy-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA115\u201d 3-{1-[4-(2-dimethylamino-ethyl)-phenyl]-1H-[1,2,3]triazol-4-yl}- 6,7-difluoro-1H-quinolin-2-one \u201cA116\u201d 3-{1-[4-(2-diethylamino-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl}- 6,7-difluoro-1H-quinolin-2-one \u201cA117\u201d 7-fluoro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA118\u201d 7-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA119\u201d 5-fluoro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA120\u201d 8-fluoro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA121\u201d 3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H- [1,8]naphthyridin-2-one \u201cA122\u201d 6-fluoro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-[1,8]naphthyridin-2-one \u201cA123\u201d 6-chloro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA124\u201d 3-[1-(4-[1,4]diazepan-1-yl-phenyl)-1H-[1,2,3]triazol-4-yl]-6-fluoro- 1H-[1,8]naphthyridin-2-one \u201cA125\u201d 6-fluoro-3-{1-[3-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA126\u201d 7-chloro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA127\u201d 5,6-difluoro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA128\u201d 6,7-difluoro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA129\u201d 6-fluoro-3-{1-[4-(piperazine-1-sulfonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA130\u201d 6,7-difluoro-3-{1-[4-(2-piperazin-1-yl-ethoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA131\u201d 6-fluoro-3-{1-[4-(3-piperazin-1-yl-propoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA132\u201d 6-fluoro-3-{1-[4-(piperidine-4-carbonyl)-phenyl]1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA133\u201d 6-fluoro-3-{1-[4-(2-piperidin-4-yl-ethoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA134\u201d 6,7-difluoro-3-{1-[4-(2-piperidin-4-yl-ethoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA135\u201d 6,7-difluoro-3-{1-[4-(3-piperazin-1-yl-propoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA136\u201d 6,7-difluoro-3-{1-[4-(piperidine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA137\u201d 6-methyl-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA138\u201d 5,7-difluoro-3-{1-[1-(2-oxo-2-piperazin-1-yl-ethyl)-1H-indol-5-yl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA139\u201d 6,7-difluoro-3-{1-[1-(2-oxo-2-piperazin-1-yl-ethyl)-1H-indol-5-yl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA140\u201d 6,7-difluoro-3-{1-[4-(2-oxo-2-piperazin-1-yl-ethoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA141\u201d 6-fluoro-3-{1-[4-(2-oxo-2-piperazin-1-yl-ethoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA142\u201d 3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-7- trifluoromethyl-1H-quinolin-2-one \u201cA143\u201d 3-{1-[4-(4-amino-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA144\u201d 3-{1-[4-(4-amino-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-6-fluoro-1H-quinolin-2-one \u201cA145\u201d 6,7-difluoro-3-{1-[4-(2-oxo-piperazin-1-yl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA146\u201d 6,7-difluoro-3-{1-[1-(2-oxo-2-piperazin-1-yl-ethyl)-1H-indazol-5- yl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA147\u201d 6-fluoro-7-methoxy-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA148\u201d 6-chloro-7-fluoro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA149\u201d 5-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA150\u201d 8-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA151\u201d 6-chloro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA152\u201d 5,7-difluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA153\u201d 6-Fluoro-3-{1-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA154\u201d 7-chloro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA155\u201d 6-fluoro-3-{1-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-[1,8]naphthyridin-2-one \u201cA156\u201d 5,6-difluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA157\u201d 6,7-difluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA158\u201d 6-fluoro-3-{1-[4-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA159\u201d 6,7-difluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenyl}- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA160\u201d 6-fluoro-3-(1-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-phenyl}-1H- [1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA161\u201d 6-fluoro-3-{1-[4-(1-methyl-piperidine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA162\u201d 6,7-difluoro-3-(1-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-phenyl}- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA163\u201d 6-fluoro-3-(1-{4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-phenyl}-1H- [1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA164\u201d 6,7-difluoro-3-{1-[4-(1-methyl-piperidine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA165\u201d 6-fluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxy]- phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA166\u201d 6,7-difluoro-3-(1-{4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-phenyl}- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA167\u201d 6,7-difluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxy]- phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA168\u201d 6-methyl-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA169\u201d 6,7-difluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]- phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA170\u201d 3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-7-trifluoromethyl-1H-quinolin-2-one \u201cA171\u201d 3-{1-[4-(4-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA172\u201d 3-{1-[4-(4-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA173\u201d 6,7-difluoro-3-(1-{1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H- indazol-5-yl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA174\u201d 6,7-difluoro-3-{1-[4-(4-methyl-2-oxo-piperazin-1-yl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA175\u201d 6-Fluoro-3-(1-{4-[4-(2-methoxy-ethyl)-piperazine-1-carbonyl]- phenyl}-1H-[1,2,3]triazol-4-yl)-1H-[1,8]naphthyridin-2-one \u201cA176\u201d 6-fluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenyl}-1H- [1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA177\u201d 3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-2- oxo-1,2-dihydro-quinoline-7-carbonitrile \u201cA178\u201d 6-fluoro-3-(1-{1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H- indol-5-yl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA179\u201d acetic acid (R)-1-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzoyl}-pyrrolidin-3-yl ester \u201cA180\u201d acetic acid (S)-1-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzoyl}-pyrrolidin-3-yl ester \u201cA181\u201d 6-fluoro-3-{1-[4-((R)-3-hydroxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA182\u201d 6-fluoro-3-{1-[4-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA183\u201d 6-fluoro-3-{1-[4-(4-hydroxy-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA184\u201d 6-fluoro-3-{1-[4-(3-hydroxy-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA185\u201d 4-methyl-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA186\u201d 6,7-Difluoro-3-{1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA187\u201d N-(2-diethylamino-ethyl)-4-[4-(6,7-difluoro-2-oxo-1,2-dihydro- quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide \u201cA188\u201d 4-[4-(7-chloro-6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-N-(2-diethylamino-ethyl)-benzamide \u201cA189\u201d 3-(1-{4-[4-(2-diethylamino-ethyl)-piperazine-1-carbonyl]-phenyl}- 1H-[1,2,3]triazol-4-yl)-6,7-difluoro-1H-quinolin-2-one \u201cA190\u201d 6-fluoro-3-{1-[4-(4-methoxy-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA191\u201d 6,7-difluoro-3-{1-[4-(4-methoxy-piperidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA192\u201d 6,7-difluoro-3-{1-[4-((R)-3-methoxy-piperidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA193\u201d 6,7-difluoro-3-{1-[4-((S)-3-methoxy-piperidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA194\u201d 6-fluoro-3-{1-[4-((R)-3-methoxy-piperidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-on \u201cA195\u201d 6-fluoro-3-{1-[4-((S)-3-methoxy-piperidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA196\u201d N-(2-diethylamino-ethyl)-4-[4-(6-fluoro-2-oxo-1,2-dihydro- quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide \u201cA197\u201d 6-fluoro-3-{1-[4-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA198\u201d 6-fluoro-3-{1-[4-((R)-2-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA199\u201d 6-fluoro-3-{1-[4-((R)-3-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA200\u201d 6,7-difluoro-3-{1-[4-((R)-3-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA201\u201d 6,7-difluoro-3-{1-[4-((S)-3-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA202\u201d 6-fluoro-3-{1-[4-((S)-3-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA203\u201d 3-(1-{4-[3-(2-diethylamino-ethoxy)-pyrrolidine-1-carbonyl]- phenyl}-1H-[1,2,3]triazol-4-yl)-6-fluoro-1H-quinolin-2-one \u201cA204\u201d 6-fluoro-3-{1-[4-(2-oxa-7-aza-spiro[4.4]nonane-7-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA205\u201d 6-fluoro-3-{1-[4-(2-oxa-6-aza-spiro[3.4]octane-6-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA206\u201d 6-fluoro-3-{1-[4-(3-hydroxymethyl-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA207\u201d 3-{1-[4-(3-dimethylamino-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA208\u201d 6-fluoro-3-(1-{4-[3-(4-hydroxy-piperidin-1-yl)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA209\u201d 6-fluoro-3-(1-{4-[3-(2-morpholin-4-yl-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA210\u201d 6-fluoro-3-(1-{4-[(R)-3-(2-methoxy-ethoxymethyl)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA211\u201d 4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]- N-(2-methoxy-ethyl)-N-methyl-benzamide \u201cA212\u201d 4-[4-(6,7-difluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1- yl]-N-(2-methoxy-ethyl)-N-methyl-benzamide \u201cA213\u201d 6-fluoro-3-{1-[4-((R)-3-hydroxymethyl-morpholine-4-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA214\u201d 6-fluoro-3-{1-[4-(2-hydroxymethyl-piperidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA215\u201d 6-fluoro-3-{1-[4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA216\u201d 6-fluoro-3-{1-[4-((S)-3-hydroxymethyl-morpholine-4-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA217\u201d 3-{1-[4-((2S,5S)-2,5-bis-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA218\u201d 3-{1-[4-((2R,5R)-2,5-bis-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA219\u201d 3-{1-[4-((2S,5S)-2,5-bis-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA220\u201d 3-{1-[4-((2R,5R)-2,5-bis-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA221\u201d 6,7-difluoro-3-(1-{4-[3-(2-morpholin-4-yl-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA222\u201d 6-fluoro-7-methyl-3-{1-[4-(4-methyl-piperazine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA223\u201d 6,7-difluoro-3-(1-{4-[(R)-3-(2-methoxy-ethoxymethyl)-pyrrolidine- 1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA224\u201d 6-fluoro-3-(1-{4-[3-(2-pyrrolidin-1-yl-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA225\u201d 6,7-difluoro-3-(1-{4-[3-(2-pyrrolidin-1-yl-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA226\u201d (R)-1-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzoyl}-pyrrolidine-3-carboxylic acid amide \u201cA227\u201d 6-fluoro-3-{1-[4-((2S,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA228\u201d 6-fluoro-3-{1-[4-(2-oxa-6-aza-spiro[3.5]nonane-6-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA229\u201d 6-fluoro-3-{1-[4-(2-oxa-7-aza-spiro[3.5]nonane-7-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA230\u201d 6-fluoro-3-{1-[4-(4-oxetan-3-yl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA231\u201d 3-{1-[4-(2,5-dioxa-8-aza-spiro[3.5]nonane-8-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA232\u201d 4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]- N-oxetan-3-yl-benzamide \u201cA233\u201d 6,7-difluoro-3-(1-{4-[(S)-3-(2-methoxy-ethoxymethyl)-pyrrolidine- 1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA234\u201d 6-fluoro-3-{1-[4-(2-oxa-5-aza-spiro[3.4]octane-5-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA235\u201d 6-fluoro-3-{1-[4-(2-oxa-6-aza-spiro[3.3]heptane-6-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA236\u201d 6-fluoro-3-(1-{4-[(S)-3-(2-methoxy-ethoxymethyl)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA237\u201d 3-{1-[4-((3R,4S)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA238\u201d 4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]- N,N-bis-(2-methoxy-ethyl)-benzamide \u201cA239\u201d 3-{1-[4-(3-diethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA240\u201d N-(3-acetyl-3-aza-bicyclo[3.1.0]hex-6-yl)-4-[4-(6-fluoro-2-oxo-1,2- dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide \u201cA241\u201d 6-fluoro-3-{1-[4-((2S,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA242\u201d (S)-1-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzoyl}-pyrrolidine-2-carboxylic acid amide \u201cA243\u201d (S)-1-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzoyl}-pyrrolidine-3-carboxylic acid amide \u201cA244\u201d 6-fluoro-3-{1-[4-((2R,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA245\u201d 6-fluoro-3-{1-[4-(2-oxa-5-aza-spiro[3.5]nonane-5-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA246\u201d 6-chloro-3-{1-[4-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA247\u201d 6-chloro-3-{1-[4-((2R,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA248\u201d 6-chloro-3-{1-[4-((2S,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA249\u201d 6-chloro-3-(1-{4-[3-(4-hydroxy-piperidin-1-yl)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA250\u201d 6-chloro-3-{1-[4-(4-oxetan-3-yl-piperazine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA251\u201d 6-fluoro-3-(1-{4-[(S)-3-(2-methoxy-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA252\u201d 6-fluoro-3-(1-{4-[(R)-3-(2-methoxy-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA253\u201d 6-chloro-3-{1-[4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA254\u201d 6-chloro-3-{1-[4-(3-dimethylamino-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA255\u201d 6-chloro-3-{1-[4-(2-hydroxymethyl-piperidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA256\u201d 6-chloro-3-{1-[4-(2-oxa-7-aza-spiro[3.5]nonane-7-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA257\u201d 6-chloro-3-{1-[4-(2-oxa-6-aza-spiro[3.4]octane-6-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA258\u201d 6-chloro-3-{1-[4-(2-oxa-6-aza-spiro[3.3]heptane-6-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA259\u201d 6-chloro-3-(1-{4-[(S)-3-(2-methoxy-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA260\u201d 6-chloro-3-(1-{4-[(R)-3-(2-methoxy-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA261\u201d 6-fluoro-3-(1-{4-[(R)-3-(2-methoxy-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-pyrazol-4-yl)-1H-quinolin-2-one \u201cA262\u201d (R)-1-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-benzoyl}-pyrrolidine-2-carboxylic acid amide \u201cA263\u201d 3-{1-[4-((3R,4R)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA264\u201d 3-{1-[4-((3S,4S)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA265\u201d 6-fluoro-3-{1-[4-((S)-3-fluoro-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA266\u201d 6-chloro-3-{1-[4-((S)-3-fluoro-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA267\u201d 3-{1-[4-(3,3-difluoro-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA268\u201d 6-chloro-3-{1-[4-(3,3-difluoro-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA269\u201d 6-fluoro-3-{1-[4-((R)-3-fluoro-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA270\u201d 6-chloro-3-{1-[4-((R)-3-fluoro-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA271\u201d 6-chloro-3-{1-[4-((3R,4R)-3,4-dimethoxy-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA272\u201d 6-chloro-3-{1-[4-((3S,4S)-3,4-dimethoxy-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA273\u201d 6-fluoro-3-{1-[4-(pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol- 4-yl}-1H-quinolin-2-one \u201cA274\u201d 6-fluoro-3-{1-[4-((R)-4-hydroxy-isoxazolidine-2-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA275\u201d 6-chloro-3-{1-[4-((R)-4-hydroxy-isoxazolidine-2-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA276\u201d 6-fluoro-3-{1-[4-((S)-4-hydroxy-isoxazolidine-2-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA277\u201d 6-chloro-3-{1-[4-((S)-4-hydroxy-isoxazolidine-2-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA278\u201d 6-fluoro-3-{1-[4-((R)-2-pyrrolidin-1-ylmethyl-pyrrolidine-1- carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA279\u201d 6-fluoro-3-{1-[4-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidine-1- carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA280\u201d 3-{1-[4-(azetidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-6- fluoro-1H-quinolin-2-one \u201cA281\u201d 6-fluoro-3-(1-{4-[2-(4-methyl-piperazine-1-carbonyl)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA282\u201d 6-fluoro-3-{1-[4-((R)-3-methanesulfonyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA283\u201d 6-fluoro-3-{1-[4-((S)-3-methanesulfonyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA284\u201d 6-fluoro-3-{1-[4-(3-methanesulfonylmethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA285\u201d 6-fluoro-3-(1-{4-[2-(1-methyl-1H-pyrazol-4-yl)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA286\u201d 6-fluoro-3-{1-[4-(2-pyridin-3-yl-pyrrolidine-1-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA287\u201d 6-fluoro-3-(1-{4-[2-(4-methyl-piperazin-1-ylmethyl)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA288\u201d 6-fluoro-3-{1-[4-(2-methyl-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA289\u201d 6-fluoro-3-{1-[4-(2-methyl-2,6-diaza-spiro[3.4]octane-6-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA290\u201d 6-chloro-3-{1-[4-(2-methyl-2,6-diaza-spiro[3.4]octane-6-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA291\u201d 6-fluoro-3-{1-[4-((3aR,6aR)-5-methyl-hexahydro-pyrrolo[3,4- b]pyrrole-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA292\u201d 6-chloro-3-{1-[4-((R)-2-methyl-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA293\u201d 3-{1-[4-(2,2-dimethyl-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA294\u201d 6-fluoro-3-(1-{4-[3-(4-methyl-piperazine-1-carbonyl)-pyrrolidine-1- carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one \u201cA295\u201d 6-fluoro-3-{1-[4-((R)-2-methyl-pyrrolidine-1-carbonyl)-phenyl]-1H- pyrazol-4-yl}-1H-quinolin-2-one \u201cA296\u201d 6-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- pyrazol-4-yl}-1H-quinolin-2-one \u201cA297\u201d 6-fluoro-3-{1-[4-((S)-3-methoxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-pyrazol-4-yl}-1H-quinolin-2-one \u201cA298\u201d 6-fluoro-3-{1-[4-((R)-3-methoxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-pyrazol-4-yl}-1H-quinolin-2-one \u201cA299\u201d 6-fluoro-3-(1-{4-[(S)-3-(2-methoxy-ethoxy)-pyrrolidine-1- carbonyl]-phenyl}-1H-pyrazol-4-yl)-1H-quinolin-2-one \u201cA300\u201d 3-{1-[4-((3R,4R)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-pyrazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA301\u201d 6-fluoro-3-{1-[4-((2S,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine- 1-carbonyl)-phenyl]-1H-pyrazol-4-yl}-1H-quinolin-2-one \u201cA302\u201d 6-fluoro-3-{1-[4-((2R,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine- 1-carbonyl)-phenyl]-1H-pyrazol-4-yl}-1H-quinolin-2-one \u201cA303\u201d 3-{1-[4-(3S,4S)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl]- 1H-pyrazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA304\u201d 6,7-difluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- pyrazol-4-yl}-1H-quinolin-2-one \u201cA305\u201d 6-chloro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H- pyrazol-4-yl}-1H-quinolin-2-one \u201cA306\u201d 3-{1-[4-((S)-3-amino-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA307\u201d 6,7-difluoro-3-{1-[4-((cis)-hexahydro-pyrrolo[3,4-c]pyrrole-2- carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA308\u201d 6-fluoro-3-{1-[4-((cis)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA309\u201d 3-{1-[4-((R)-3-amino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA310\u201d 3-{1-[4-((S)-3-amino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA311\u201d 6-Fluoro-3-{1-[4-((R)-3-methylamino-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA312\u201d 6-fluoro-3-{1-[4-((S)-3-methylamino-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA313\u201d 3-{1-[4-((R)-3-amino-pyrrolidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA314\u201d 6-fluoro-3-{1-[4-((R)-3-hydroxymethyl-piperazine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA315\u201d 6-fluoro-3-{1-[4-((S)-2-hydroxymethyl-piperazine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA316\u201d 6-fluoro-3-{1-[4-((R)-2-hydroxymethyl-piperazine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA317\u201d 3-{1-[4-(6-amino-3-aza-bicyclo[3.1.0]hexane-3-carbonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA318\u201d 6-chloro-3-{1-[4-((S)-2-dimethylaminomethyl-pyrrolidine-1- carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA319\u201d 3-{1-[4-((S)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA320\u201d 3-{1-[4-((R)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA321\u201d 3-{1-[4-((R)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA322\u201d 6-chloro-3-{1-[4-((R)-2-dimethylaminomethyl-pyrrolidine-1- carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA323\u201d 3-{1-[4-((S)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA324\u201d 3-{1-[4-((S)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-pyrazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA325\u201d 3-{1-[4-((R)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-pyrazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA326\u201d 3-{1-[4-((S)-3-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA327\u201d 6-fluoro-3-{1-[4-((cis)-5-methyl-hexahydro-pyrrolo[3,4-c]pyrrole-2- carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA328\u201d 3-{1-[4-((R)-3-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA329\u201d 3-{1-[4-((S)-3-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA330\u201d 3-{1-[4-(6-dimethylamino-3-aza-bicyclo[3.1.0]hexane-3-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA331\u201d 3-{1-[4-((R)-3-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA332\u201d 3-{1-[4-((S)-3-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA333\u201d 3-{1-[4-((R)-3-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-7-fluoro-1H-quinolin-2-one \u201cA334\u201d 3-{1-[4-((R)-3-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA335\u201d 3-{1-[4-((R)-3-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one \u201cA336\u201d 3-{1-[4-((S)-3-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-7-fluoro-1H-quinolin-2-one \u201cA337\u201d 3-{1-[4-((S)-3-diethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA338\u201d 3-{1-[4-((R)-3-diethylamino-piperidine-1-carbonyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA339\u201d 3-{1-[4-(4-dimethylamino-3,3-difluoro-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA340\u201d 3-{1-[4-((S)-3-dimethylaminomethyl-pyrrolidine-1-carbonyl)- phenyl]-1H-pyrazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA341\u201d 3-{1-[4-((trans)-3-dimethylamino-4-fluoro-pyrrolidine-1-carbonyl)- phenyl]-1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one \u201cA342\u201d 6-fluoro-3-[1-(4-methylamino-phenyl)-1H-[1,2,3]triazol-4-yl]-1H- quinolin-2-one \u201cA343\u201d (R)-tetrahydro-furan-2-carboxylic acid {4-[4-(6-fluoro-2-oxo-1,2- dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-phenyl}-methyl-amide \u201cA344\u201d (S)-tetrahydro-furan-2-carboxylic acid {4-[4-(6-fluoro-2-oxo-1,2- dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-phenyl}-methyl-amide \u201cA345\u201d tetrahydro-pyran-4-carboxylic acid {4-[4-(6-fluoro-2-oxo-1,2- dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-phenyl}-methyl-amide \u201cA346\u201d (R)\u2014N-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-phenyl}-2-methoxy-N-methyl-propionamide \u201cA347\u201d (2S,4S)-4-methoxy-pyrrolidine-2-carboxylic acid {4-[4-(6-fluoro-2- oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-phenyl}-methyl- amide \u201cA348\u201d (S)\u2014N-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-phenyl}-2-methoxy-N-methyl-propionamide \u201cA349\u201d 1-methyl-piperidine-4-carboxylic acid {4-[4-(6-fluoro-2-oxo-1,2- dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-phenyl}-methyl-amide \u201cA350\u201d 6-fluoro-3-{1-[5-((S)-3-methoxy-pyrrolidine-1-carbonyl)-thiophen- 3-yl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA351\u201d 6-fluoro-3-{1-[5-((R)-3-methoxy-pyrrolidine-1-carbonyl)-thiophen- 3-yl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA352\u201d N-{4-[4-(6,7-difluoro-2-oxo-1,2-dihydro-quinolin-3-yl)- [1,2,3]triazol-1-yl]-phenyl}-N-methyl-acetamide \u201cA353\u201d N-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1- yl]-phenyl}-N-methyl-acetamide \u201cA354\u201d 6-fluoro-3-[1-(2-methyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)-1H- [1,2,3]triazol-4-yl]-1H-quinolin-2-one \u201cA355\u201d 6-Fluoro-3-{1-[4-((trans)-3-methoxy-cyclopentyloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA356\u201d 6-chloro-3-{1-[4-((1S,3R)-3-methoxy-cyclopentyloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA357\u201d 6-fluoro-3-[1-(4-methoxy-phenyl)-1H-[1,2,3]triazol-4-yl]-1H- quinolin-2-one \u201cA358\u201d 6-fluoro-3-{1-[4-((R)-3-methoxy-pyrrolidine-1-sulfonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA359\u201d 6-chloro-3-{1-[4-((R)-3-methoxy-pyrrolidine-1-sulfonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA360\u201d 6-fluoro-3-{1-[4-((S)-3-methoxy-pyrrolidine-1-sulfonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA361\u201d 6-chloro-3-{1-[4-((S)-3-methoxy-pyrrolidine-1-sulfonyl)-phenyl]- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA362\u201d 6-fluoro-3-{1-[4-(1S,2S)-2-methoxy-cyclopentyloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA363\u201d 6-chloro-3-[1-(4-cyclopentyloxy-phenyl)-1H-[1,2,3]triazol-4-yl]-1H- quinolin-2-one \u201cA364\u201d 3-[1-(4-cyclopentyloxy-phenyl)-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H- quinolin-2-one \u201cA365\u201d 6-fluoro-3-{1-[4-(tetrahydro-furan-3-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA366\u201d 6-chloro-3-{1-[4-(tetrahydro-furan-3-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA367\u201d 6-fluoro-3-{1-[4-((R)-1-methyl-pyrrolidin-3-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA368\u201d 6-chloro-3-{1-[4-((S)-1-methyl-pyrrolidin-3-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA369\u201d 6-chloro-3-{1-[4-((R)-1-methyl-pyrrolidin-3-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA370\u201d 6-fluoro-3-{1-[4-((S)-1-methyl-pyrrolidin-3-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA371\u201d 6-fluoro-3-{1-[4-(1-methyl-piperidin-4-ylmethyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA372\u201d 6,7-difluoro-3-{1-[4-((S)-1-methyl-pyrrolidin-3-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA373\u201d 6,7-difluoro-3-{1-[4-((R)-1-methyl-pyrrolidin-3-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA374\u201d 6-chloro-3-{1-[4-(1-methyl-piperidin-4-ylmethyl)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA375\u201d 6-fluoro-3-{1-[4-(1-methyl-piperidin-4-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one \u201cA376\u201d 6-chloro-3-{1-[4-(1-methyl-piperidin-4-yloxy)-phenyl]-1H- [1,2,3]triazol-4-yl}-1H-quinolin-2-one and pharmaceutically acceptable solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 95.0
- Lexical Diversity: 1.71875
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14909365', '15566933', '13546039', '14772865', '14908217']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7853481158512835
- 35 USC 102 Novelty (BERT): 0.5307038889811299
- Combined Prediction Score: 0.7598836931642682
- Mean Citation Score: 331.6542
- Max Citation Score: 348.71225
- Similarity Product: 288.736344268024

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test