PATENT CLAIM ANALYSIS

Application Number: 16135540
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["435", "235100"]

Abstract:
The invention provides a targeted bacteriophage-polymer complex comprising a recombinant targeted-bacteriophage and a cationic polymer. The complex has a net positive charge. The invention provides methods of preparing bacteriophages and complexes thereof, and to their uses for the delivery of transgenes in a variety of gene therapy applications.

Claim (Index 45):
A targeted bacteriophage-polymer complex comprising a recombinant negatively charged targeted-bacteriophage and a cationic polymer selected from the group consisting of poly-D-lycine (PDL), diethylaminoethyl-dextran (DEAE.DEX) and polyethyleneimine (PEI), wherein the recombinant bacteriophage comprises a nucleic acid sequence, which encodes a protein ligand that is capable of being expressed on the capsid coat of the recombinant bacteriophage, and which is specific for a protein expressed on a mammalian target cell or tissue, so as to enable targeted delivery thereto, wherein the complex has a net positive charge and a \u03b6-potential of at least 5 mV at physiological pH, and wherein the complex comprises a weight:weight ratio of about 100 ng to 400 ng polymer:1 \u03bcg phage.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 97.0
- Lexical Diversity: 1.40541
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13403765', '12714147', '10530168', '14223944', '15380734']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.595016092727248
- 35 USC 102 Novelty (BERT): 0.5147976448889288
- Combined Prediction Score: 0.5869942479434161
- Mean Citation Score: 247.124258
- Max Citation Score: 314.16943
- Similarity Product: 225.323863548032

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test