PATENT CLAIM ANALYSIS

Application Number: 16059708
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-03
Patent Classification: ["514", "04400A"]

Abstract:
The application relates to methods of treatment and treatment regimens for Alpha-1 Antitrypsin deficiency (AATD) and the conditions, manifestations, and diseases caused by AATD, by the administration of one or more expression-inhibiting oligomeric compounds having a nucleobase sequence complementary to a coding sequence in the Alpha-1 Antitrypsin (A1AT or AAT) gene that inhibits the expression of the AAT gene, in combination with one or more autophagy enhancing agents that enhance and/or induce the endogenous autophagy mechanism to facilitate and encourage clearance of polymerized mutant AAT protein accumulated in the endoplasmic reticulum of hepatocytes. When used in combination, delivery of the expression-inhibiting oligomeric compounds to liver cells in vivo provides for inhibition of AAT gene expression and the use of autophagy enhancing agents increases the rate of the intracellular autophagy mechanism to clear polymerized mutant Z-AAT protein accumulated in cells, leading to an improved treatment of AATD and prevention and treatment of conditions and diseases associated with AATD.

Claim (Index 20):
The method of  claim 18 , wherein the count, size, and/or area percentage of Z-AAT globules retained in the liver cell, cell, tissue, or organism, is reduced compared to pre-treatment levels.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 96.0
- Lexical Diversity: 2.03614
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14740307', '15867107', '15399820', '14284745', '14113118']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8091449466989674
- 35 USC 102 Novelty (BERT): 0.5887660422320208
- Combined Prediction Score: 0.7871070562522727
- Mean Citation Score: 412.38412199999993
- Max Citation Score: 607.01807
- Similarity Product: 391.9467784638477

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test