PATENT CLAIM ANALYSIS

Application Number: 15957730
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["514", "002800"]

Abstract:
Some embodiments include compounds that can inhibit the growth of bacterial and/or inhibit or reduce microbial infections caused by one or more microorganisms (e.g.,  Pseudomonas aeruginosa  and  Cryptococcus neoformans ) and methods of using these compounds to treat microbial infection and outbreaks and/or to reduce the formation of biofilms. Other embodiments include synthesis of the compounds that can inhibit the growth of one or more microorganisms and/or inhibit or reduce microbial infections.

Claim (Index 1):
A compound, comprising formula: wherein:\n R 1  is selected from the group consisting of: biphenyl, \u2014(CH 2 ) n -biphenyl, biphenyl ketone, naphthalene, anthracene, benzyl optionally substituted with 1 to 3 halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, \u2014OH, \u2014NH 2 , \u2014NO 2 , \u2014CN, or \u2014CF 3 , and phenyl optionally substituted with 1 to 3 halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, \u2014OH, \u2014NH 2 , \u2014NO 2 , \u2014CN, or \u2014CF 3 ; \n R 2  is selected from the group consisting of: \u2014OH, \u2014NHR 4 , and \u2014NR 4 R 5 ; \n R 3  is selected from the group consisting of: \u2014NH 2  and NH\u2014C(O)CR 6 R 7 ; \n R 4  and R 5  are independently selected from the group consisting of: H, halogen, C 1 -C 6  alkyl being unbranched, branched or cyclic, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, hydroxyl, acyl, acyl amides, carboxyl, tetrazolyl, and \u2014(CH 2 ) n \u2014R 8 ; \n alternatively, R 4  and R 5  are taken together to form a pyridine, a piperidine, a pyrrole, or a pyrrolidine ring optionally substituted with C 1 -C 6  alkyl, C 1 -C 6  alkoxy, or carboxyl; \n R 6  and R 7  are independently selected from the group consisting of: H, \u2014NH 2 , NHR 12 , benzyl optionally substituted with 1 to 3 halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, \u2014OH, \u2014NH 2 , \u2014NO 2 , \u2014CN, or \u2014CF 3 , and phenyl optionally substituted with 1 to 3 halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, \u2014OH, \u2014NH 2 , \u2014NO 2 , \u2014CN, or \u2014CF 3 , C 1 -C 6  alkyl being unbranched, branched or cyclic, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, hydroxyl, acyl, acyl amides, carboxyl, tetrazolyl, and \u2014(CH 2 ) n \u2014R 9 ; alternatively, R 6  and R 7  are taken together to form a pyridine, a piperidine, a pyrrole, or a pyrrolidine ring optionally substituted with C 1 -C 6  alkyl, C 1 -C 6  alkoxy, or carboxyl; \n R 8  is \u2014OH, \u2014CF 3 , morpholinyl, pyridinyl, benzyl optionally substituted with 1 to 3 halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, \u2014OH, \u2014NH 2 , \u2014NO 2 , \u2014CN, or \u2014CF 3 , or phenyl optionally substituted with 1 to 3 halogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, \u2014OH, \u2014NH 2 , \u2014NO 2 , \u2014CN, or \u2014CF 3 ; \n R 9  is indole, pyrrole, morpholinyl, pyridinyl, imidazole, guanidyl, C(O)NH 2 , benzyl optionally substituted with 1 to 3 halogens, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, \u2014OH, \u2014NH 2 , \u2014NO 2 , \u2014CN, or \u2014CF 3 , or phenyl optionally substituted with 1 to 3 halogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, \u2014OH, \u2014NH 2 , \u2014NO 2 , \u2014CN, or \u2014CF 3 , SR 14 , or \u2014NHCR 10 R 11 ; \n R 10  and R 11  are independently selected from the group consisting of: H, NH, and NH 2 ; \n R 12  is C 1 -C 6  alkyl or C(O)R 13 ; \n R 13  is C 1 -C 6  alkyl or aryl; and \n R 14  is hydrogen, C 1 -C 6  alkyl, or aryl; and \n n is 1, 2, 3, or 4; \n or a pharmaceutically acceptable salt thereof, or a metabolite thereof.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 91.0
- Lexical Diversity: 1.80952
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12099135', '12862955', '16091685', '13722912', '13983747']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7731026989064073
- 35 USC 102 Novelty (BERT): 0.5077470007249318
- Combined Prediction Score: 0.7465671290882597
- Mean Citation Score: 286.423948
- Max Citation Score: 294.3814
- Similarity Product: 233.544898852098

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test