PATENT CLAIM ANALYSIS

Application Number: 16225920
Application Type: Utility
Filing Date: 2018-12
Publication Date: 2019-05
Patent Classification: ["514", "210200"]

Abstract:
The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.

Claim (Index 38):
The compound of  claim 1 , selected from the group consisting of:\n 4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[(2-oxo-1H-pyridin-3-yl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; methyl 2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]acetate; methyl 2,2-dimethyl-3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propanoate; ethyl 2-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethoxy]acetate; methyl (2R)-1-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethyl]pyrrolidine-2-carboxylate; 4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[2-methyl-4-(trifluoromethoxy)phenyl]phthalazin-1-one; 2-(6-tert-butyl-3-pyridyl)-4-[(1-methyl-2-oxo-3-pyridyl)amino]phthalazin-1-one; 2-(2-tert-butylpyrimidin-5-yl)-4-[(1-methyl-2-oxo-3-pyridyl)amino]phthalazin-1-one; 2-[4-(3-methyl oxetan-3-yl)phenyl]-4-[(1-methyl-2-oxo-3-pyridyl)amino]phthalazin-1-one; 4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(oxetan-3-yl)phenyl]phthalazin-1-one; 2-(4-cyclopropylphenyl)-4-[(1-methyl-2-oxo-3-pyridyl)amino]phthalazin-1-one; 2-[4-(2-methoxyethoxy)phenyl]-4-[(1-methyl-2-oxo-3-pyridyl)amino]phthalazin-1-one; 2-(4-tert-butylphenyl)-4-[(1-methyl-2-oxo-3-pyridyl)amino]phthalazin-1-one; 2-(4-tert-butylphenyl)-4-[(2-oxo-1H-pyridin-3-yl)amino]phthalazin-1-one; 7-methoxy-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 8-fluoro-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 5-fluoro-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 5-methoxy-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 2-(4-tert-butylphenyl)-7-ethyl-4-[(1-methyl-2-oxo-3-pyridyl)amino]phthalazin-1-one; 4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrophthalazin-1-one; 4-[(1-methyl-6-oxo-pyrimidin-5-yl)amino]-2-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrophthalazin-1-one; methyl 1-methyl-6-oxo-5-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrophthalazin-1-yl]amino]pyridine-3-carboxylate; methyl 2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrophthalazin-1-yl]amino]-1-pyridyl]acetate; 4-[[1-[2-(dimethylamino)ethyl]-6-oxo-pyrimidin-5-yl]amino]-2-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrophthalazin-1-one; 2-(6-tert-butyl-3-pyridyl)-4-[(1-methyl-2-oxo-3-pyridyl)amino]-5,6,7,8-tetrahydrophthalazin-1-one; 2-[4-(difluoromethoxy)phenyl]-4-[(1-methyl-2-oxo-3-pyridyl)amino]-5,6,7,8-tetrahydrophthalazin-1-one; 1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(2,6-dimethyl-3-oxo-pyridazin-4-yl)amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(1-methyl-6-oxo-pyrimidin-5-yl)amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(5-fluoro-1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(1,5-dimethyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(5-chloro-1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[1-methyl-2-oxo-5-(trifluoromethyl)-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(5-ethyl-1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(5-isopropyl-1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; methyl 4-[5-chloro-2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]butanoate; methyl 4-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]butanoate; ethyl 2-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethoxy]acetate; 1-[[1-(2-imidazol-1-ylethyl)-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; ethyl 4-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethyl]morpholine-2-carboxylate; 1-[[1-[2-(3-methoxypyrrolidin-1-yl)ethyl]-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 2-[tert-butoxycarbonyl-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethyl]amino]acetic acid; 1-[[1-(3-morpholinopropyl)-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; tert-butyl N-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethyl]carbamate; 1-[[1-[2-(3-hydroxyazetidin-1-yl)ethyl]-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[1-(2-hydroxyethyl)-6-oxo-pyrimidin-5-yl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[1-[3-(4-methylpiperazin-1-yl)propyl]-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[1-(3-hydroxypropyl)-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[1-[2-(dimethylamino)ethyl]-6-oxo-pyrimidin-5-yl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[1-[2-(diethylamino)ethyl]-6-oxo-pyrimidin-5-yl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[6-oxo-1-(2-pyrrolidin-1-ylethyl)pyrimidin-5-yl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 3-(4-tert-butyl-2-fluoro-phenyl)-1-[(1-methyl-2-oxo-3-pyridyl)amino]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 3-[2-fluoro-4-(trifluoromethyl)phenyl]-1-[(1-methyl-2-oxo-3-pyridyl)amino]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 3-(6-ethoxy-3-pyridyl)-1-[(1-methyl-2-oxo-3-pyridyl)amino]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 3-(6-methoxy-3-pyridyl)-1-[(1-methyl-2-oxo-3-pyridyl)amino]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(5-fluoro-1-methyl-2-oxo-3-pyridyl)amino]-3-(6-methoxy-3-pyridyl)-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 3-(6-tert-butyl-3-pyridyl)-1-[(1-methyl-2-oxo-3-pyridyl)amino]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 3-[4-(difluoromethoxy)phenyl]-1-[(1-methyl-2-oxo-3-pyridyl)amino]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 6,6-dimethyl-1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-5,7-dihydrocyclopenta[d]pyridazin-4-one; 1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrano[3,4-d]pyridazin-4-one; 4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrano[3,4-d]pyridazin-1-one; 4-[(1,6-dimethyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[(2-methyl-6-oxo-1H-pyrimidin-5-yl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[(1-methyl-6-oxo-pyrimidin-5-yl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[(5-ethyl-1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[(6-methyl-2-oxo-1H-pyridin-3-yl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; methyl 3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propanoate; 4-[[1-[2-(dimethylamino)ethyl]-2-oxo-3-pyridyl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[[1-(2-methoxyethyl)-2-oxo-3-pyridyl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[[1-(2-methyl sulfonylethyl)-2-oxo-3-pyridyl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; methyl 4-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]butanoate; 3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propane-1-sulfonamide; N,N-dimethyl-3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propane-1-sulfonamide; 4-[[1-(2-morpholinoethyl)-2-oxo-3-pyridyl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[[1-[2-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]ethyl]-2-oxo-3-pyridyl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[[1-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-2-oxo-3-pyridyl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; methyl (2S)-1-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethyl]pyrrolidine-2-carboxylate; 4-[[1-[2-(dimethylamino)ethyl]-6-oxo-pyrimidin-5-yl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 6-ethyl-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 7-ethyl-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]-6-vinyl-phthalazin-1-one; 4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]-7-vinyl-phthalazin-1-one; 6-acetyl-1-[(1-ethyl-6-oxo-pyrimidin-5-yl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 6-acetyl-1-[(6-oxo-1-propyl-pyrimidin-5-yl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 6-acetyl-1-[(5-fluoro-1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 4-[[1-(2-morpholino-2-oxo-ethyl)-2-oxo-3-pyridyl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; N,N-dimethyl-2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]acetamide; N-isopropyl-2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]acetamide; N-methyl-2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]acetamide; N-(2-hydroxyethyl)-2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]acetamide; N-[2-(dimethylamino)ethyl]-2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]acetamide; N-(3-methoxypropyl)-2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]acetamide; N-methyl-3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propanamide; N,N-dimethyl-3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propanamide; N-methyl-4-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]butanamide; N,N-dimethyl-4-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]butanamide; N,2,2-trimethyl-3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propanamide; N,N,2,2-tetramethyl-3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propanamide; 2,2-dimethyl-3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propanamide; N-methyl-2-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethoxy]acetamide; N,N-dimethyl-2-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethoxy]acetamide; N-methyl-2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrophthalazin-1-yl]amino]-1-pyridyl]acetamide; N-methyl-4-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]butanamide; N,N-dimethyl-4-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]butanamide; N-methyl-2-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethoxy]acetamide; N,N-dimethyl-2-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethoxy]acetamide; 3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propanoic acid; 4-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]butanoic acid; 2,2-dimethyl-3-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]propanoic acid; 2-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethoxy]acetic acid; 2-[methyl-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethyl]amino]acetic acid; 1-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethyl]pyrrolidine-2-carboxylic acid; (2S)-1-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethyl]pyrrolidine-2-carboxylic acid; (2R)-1-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]-1-pyridyl]ethyl]pyrrolidine-2-carboxylic acid; 4-[5-chloro-2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]butanoic acid; 4-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]butanoic acid; 2-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethoxy]acetic acid; 1-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethyl]pyrrolidine-3-carboxylic acid; 1-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethyl]pyrrolidine-2-carboxylic acid; 4-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethyl]morpholine-2-carboxylic acid; 4-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethyl]morpholine-3-carboxylic acid; 4-[6-oxo-5-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]pyrimidin-1-yl]butanoic acid; 7-hydroxy-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 6-hydroxy-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 1-[[1-(morpholin-3-ylmethyl)-6-oxo-pyrimidin-5-yl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[1-[2-(methylamino)ethyl]-6-oxo-pyrimidin-5-yl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 2-[2-[2-oxo-3-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl]amino]-1-pyridyl]ethylamino]acetic acid; 1-[[1-(2-aminoethyl)-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[2-oxo-1-(pyrrolidin-2-ylmethyl)-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 6-methyl-1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 6-methyl-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-1-one; 1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyridazin-4-one; 1-[[1-[[(2S)-Morpholin-2-yl]methyl]-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 6-(2-methoxyethoxy)-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 7-(2-methoxyethoxy)-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 5-(2-methoxyethoxy)-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 1-[(1-methyl-2-oxo-3-pyridyl)amino]-4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazine-6-carboxamide; 7-(1-hydroxyethyl)-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 7-(hydroxymethyl)-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 7-amino-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 7-(aminomethyl)-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 7-[(dimethylamino)methyl]-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 6-(2-hydroxypropyl)-1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 6-(2-hydroxy-2-methyl-propyl)-1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 6-(2-hydroxyethyl)-1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 6-acetyl-1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 6-acetyl-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-1-one; 6-acetyl-1-[(1-methyl-6-oxo-pyrimidin-5-yl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 6-acetyl-4-[(1-methyl-6-oxo-pyrimidin-5-yl)amino]-2-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-1-one; methyl 4-[(1-methyl-2-oxo-3-pyridyl)amino]-1-oxo-2-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazine-6-carboxylate; methyl 1-[(1-methyl-2-oxo-3-pyridyl)amino]-4-oxo-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazine-6-carboxylate; 4-[(1-methyl-2-oxo-3-pyridyl)amino]-1-oxo-2-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazine-6-carbaldehyde; 1-[(1-methyl-2-oxo-3-pyridyl)amino]-4-oxo-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazine-6-carbaldehyde; 1-[(1-methyl-2-oxo-3-pyridyl)amino]-6-methylsulfonyl-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 4-[(1-methyl-2-oxo-3-pyridyl)amino]-6-methylsulfonyl-2-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-1-one; 6-ethyl-1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; 6-isopropyl-1-[(1-methyl-2-oxo-3-pyridyl)amino]-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazin-4-one; N-methyl-4-[(1-methyl-2-oxo-3-pyridyl)amino]-1-oxo-2-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazine-6-carboxamide; N-methyl-1-[(1-methyl-2-oxo-3-pyridyl)amino]-4-oxo-3-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-pyrido[3,4-d]pyridazine-6-carboxamide; 2-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-4-[(1-methyl-2-oxo-3-pyridyl)amino]phthalazin-1-one; 4-[[1-(2-hydroxyethyl)-2-oxo-3-pyridyl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; 7-hydroxy-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrophthalazin-1-one; 6-hydroxy-4-[(1-methyl-2-oxo-3-pyridyl)amino]-2-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrophthalazin-1-one; 1-[[1-(3-amino-2-hydroxy-2-methyl-propyl)-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[2-Oxo-1-(2-oxo-2-piperazin-1-yl-ethyl)-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[1-[2-(Oxetan-3-yl amino)ethyl]-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[[1-[2-(3-Hydroxyazetidin-1-yl)ethyl]-6-oxo-pyrimidin-5-yl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; trans-1-[[1-[(5-Amino-1,3-dioxan-2-yl)methyl]-2-oxo-3-pyridyl]amino]-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 1-[(1-Methyl-2-oxo-3-pyridyl)amino]-3-[2-methyl-4-(trifluoromethoxy)phenyl]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 3-(3,4-Dimethoxyphenyl)-1-[(1-methyl-2-oxo-3-pyridyl)amino]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; 3-[3-Methoxy-4-(trifluoromethyl)phenyl]-1-[(1-methyl-2-oxo-3-pyridyl)amino]-6,7-dihydro-5H-cyclopenta[d]pyridazin-4-one; N, 1-Dimethyl-6-oxo-5-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrophthalazin-1-yl]amino]pyridine-3-carboxamide; N, 1-Dimethyl-6-oxo-5-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]pyridine-3-carboxamide; 4-[[1-methyl-2-oxo-5-(trifluoromethyl)-3-pyridyl]amino]-2-[4-(trifluoromethoxy)phenyl]phthalazin-1-one; and pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 99.0
- Percentile: 98.0
- Lexical Diversity: 1.15625
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12845045', '14458062', '13272079', '13519872', '12815800']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7901751858106019
- 35 USC 102 Novelty (BERT): 0.5096225012249233
- Combined Prediction Score: 0.762119917352034
- Mean Citation Score: 282.042748
- Max Citation Score: 286.458
- Similarity Product: 232.87103266775608

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test