PATENT CLAIM ANALYSIS

Application Number: 16147865
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["435", "285200"]

Abstract:
In an illustrative embodiment, automated multi-module cell editing instruments comprising one or more flow-through electroporation devices or modules are provided to automate genome editing in live cells.

Claim (Index 12):
An automated multi-module cell editing instrument comprising an FTEP module, wherein the multi-module cell editing instrument comprises:\n a housing configured to house all of some of the modules; a receptacle configured to receive cells; a growth module in which to grow the cells; one or more receptacles configured to receive nucleic acids; the FTEP module configured to introduce the nucleic acids into the cells; wherein the FTEP module comprises:\n a. at least one inlet and at least one inlet channel for introducing a fluid comprising cells and nucleic acids to the FTEP module; \n b. an outlet and an outlet channel for removing transformed cells and exogenous material from the FTEP module; \n c. a flow channel positioned between a first inlet channel and the outlet channel, wherein the flow channel intersects with the first inlet channel and the outlet channel and wherein a portion of the flow channel narrows between the inlet channel intersection and the outlet channel intersection; and \n d. an electrode positioned on either side of the flow channel and in direct contact with the fluid in the flow channel, the electrodes defining the narrowed portion of the flow channel; and wherein the electrodes apply one or more electric pulses to the cells in the fluid as they pass through the flow channel, thereby introducing the exogenous material into the cells in the fluid; \n an editing module configured to allow the introduced nucleic acids to edit nucleic acids in the cells; a processor configured to operate the automated multi-module cell editing instrument based on user input and/or selection of a pre-programmed script; and an automated liquid handling system to move liquids from the cell receptacle to the growth module, from the growth module to the FTEP module, and from the FTEP module to the editing module, as well as from the one or more nucleic acid receptacles to the FTEP module, all without user intervention.

Metadata:
- Claim Count in Document: 48.0
- Percentile: 97.0
- Lexical Diversity: 1.07407
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16147871', '16147120', '16147353', '16024816', '15802174']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6077096376925791
- 35 USC 102 Novelty (BERT): 0.5641312507867686
- Combined Prediction Score: 0.6033517990019981
- Mean Citation Score: 345.5263280000001
- Max Citation Score: 442.04102
- Similarity Product: 426.7521886016655

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test