PATENT CLAIM ANALYSIS

Application Number: 15942321
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "210020"]

Abstract:
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Claim (Index 1):
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein,\n R 1  is C 2-9  heteroaryl, C 2-9  heterocyclyl, C 6-10  aryl, C 3-9  cycloalkyl, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, \u2014C\u2261C\u2014(C 2-9  heteroaryl), \u2014C\u2261C\u2014(C 6-10  aryl), \u2014CH(R\u2032)\u2014O\u2014(C 2-9  heteroaryl), \u2014CH(R j\u2032 )\u2014O\u2014(C 2-9  heterocyclyl), \u2014CH(R j\u2032 )\u2014O\u2014(C 6-10  aryl), \u2014CH(R j\u2032 )\u2014O\u2014(C 3-9  cycloalkyl), \u2014CH(R j\u2032 )\u2014O\u2014(C 1-6  alkyl), \u2014C(O)N(R j\u2032 )(C 2-9  heteroaryl), \u2014C(O)N(R j\u2032 )(C 2-9  heterocyclyl), \u2014C(O)NR 24 R 25 , \u2014C(O)OR 26 , \u2014C(\u2550NR 29 )R 27 , \u2014C(\u2550NR 29 )NR 24 R 25 , \u2014C(\u2550NOR 29 )R 27 , cyano, hydrogen, halogen, \u2014NR 24 R 25 , \u2014NR 28 C(O)R 27 , \u2014NR 28 C(O)NR 24 R 25 \u2014NR 28 C(O)OR 26 , \u2014NR 28 S(O)R 29 ; \u2014NR 28 SO 2 R 29 , \u2014NR 28 SO 2 NR 24 R 25 , \u2014OR 26 , \u2014OC(O)R 27 , \u2014OC(O)NR 24 R 25 , \u2014S(O)R 29 ; \u2014SO 2 R 29 , or \u2014SO 2 NR 24 R 25 ; \n wherein the C 2-9  heteroaryl and C 2-9  heterocyclyl of R 1  independently have 1-4 heteroatoms selected from O, S and N; and wherein the C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-9  cycloalkyl, C 6-10  aryl, C 2-9  heteroaryl and C 2-9  heterocyclyl of R 1  are optionally substituted independently with one, two, three, four or five substituents; \n wherein the C 3-9  cycloalkyl, C 6-10  aryl, C 2-9  heteroaryl or C 2-9  heterocyclyl of R 1  together with two of said substituents can form a bicyclic which is optionally substituted; \n wherein a carbon embedded in said cycloalkyl, aryl, heteroaryl or heterocyclyl taken together with an oxygen to which it is bound can form a carbonyl; \n each R j\u221d0  is independently hydrogen or optionally substituted C 1-6  alkyl; \n each R 24  and R 25  is independently hydrogen or optionally substituted C 1-6  alkyl; or R 24  and R 25  are taken together with the nitrogen atom to which they are attached to form a C 3-7  heterocyclyl optionally substituted with one to four substituents; \n each R 26 , R 27  and R 28  is independently hydrogen or optionally substituted C 1-6  alkyl; \n each R 29  is independently optionally substituted C 1-6  alkyl; \n R 1\u2032  is hydrogen, C 1-6  alkyl, C 2-6  alkenyl, C 3-6  cycloalkyl, C 6-10  aryl, C 2-9  heteroaryl, or halogen, wherein said alkyl, alkenyl, cycloalkyl, aryl and heteroaryl can be optionally substituted with one, two, three, four or five substituents; provided at least one of R 1  and R 1\u2032  is other than hydrogen; \n R 2  is A-C(O)\u2014 or D; \n A is C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, C 6-10  aryl, C 2-9  heteroaryl, C 2-9  heterocyclyl, (C 3-7  cycloalkyl)-(C 1-6  alkylene)-, (C 6-10  aryl)-(Cis alkylene)-, (C 2-9  heteroaryl)-(C 1-6  alkylene)-, (C 2-9  heterocyclyl)-(C 1-6  alkylene)-, \u2014NR g R h  or \u2014OR h ;\n wherein the C 1-6  alkyl, C 3-9  cycloalkyl, C 6-10  aryl, C 2-9  heteroaryl and C 2-9  heterocyclyl of A are optionally substituted independently with one, two, three, four or five substituents; \n R g  is H or C 1-6  alkyl optionally substituted with one to four substituents independently selected from the group consisting of hydroxyl, halogen, cyano, amino, di(C 1-6  alkyl)amino, mono(C 1-6  alkyl)amino; \u2014CHF 2 , and \u2014CF 3 ; \n R h  is C 1-6  alkyl, C 3-7  cycloalkyl, C 6-10  aryl, C 2-9  heteroaryl, C 2-9  heterocyclyl, (C 3-7  cycloalkyl)-(C 1-6  alkylene)-, (C 6-10  aryl)-(C 1-6  alkylene)-, (C 2-9  heteroaryl)-(C 1-6  alkylene)-, or (C 2-9  heterocyclyl)-(C 1-6  alkylene)-;\n wherein the C 1-6  alkyl, C 3-7  cycloalkyl, C 6-10  aryl, C 2-9  heteroaryl and C 2-9  heterocyclyl of R h  are optionally substituted independently with one, two, three, four or five substituents; \n \n \n D is H, C 1-6  alkyl, C 3-7  cycloalkyl, C 6-10  aryl, C 2-9  heteroaryl, C 2-9  heterocyclyl, (C 3-7  cycloalkyl)-(C 1-6  alkylene)-, (C 6-10  aryl)-(C 1-6  alkylene)-, (C 2-9  heteroaryl)-(C 1-6  alkylene)-, (C 2-9  heterocyclyl)-(C 1-6  alkylene)-, or (C 3-7  cycloalkyl)-S(O) 2 \u2014;\n wherein the C 2-9  heteroaryl and C 2-9  heterocyclyl of D independently have 1-4 heteroatoms selected from O, S and N; and wherein the C 1-6  alkyl, C 3-7  cycloalkyl, C 6-10  aryl, C 2-9  heteroaryl and C 2-9  heterocyclyl of D are optionally substituted independently with one, two, three, four or five substituents; \n wherein two of the substituents attached to different atoms are taken together with the atoms to which they attached to form a bicyclic or tricyclic, wherein said bicyclic or tricyclic is optionally substituted; and wherein a carbon embedded in said heteroaryl or heterocyclyl taken together with an oxygen to which it is bound can form a carbonyl; \n \n and R 2\u2032  is H or optionally substituted C 1-6  alkyl.

Metadata:
- Claim Count in Document: 140.0
- Percentile: 90.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12530648', '13102720', '15281923', '13266976', '15852639']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7851310626422204
- 35 USC 102 Novelty (BERT): 0.5109322269737905
- Combined Prediction Score: 0.7577111790753774
- Mean Citation Score: 269.39763800000003
- Max Citation Score: 276.27457000000004
- Similarity Product: 208.47123787149792

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test