PATENT CLAIM ANALYSIS

Application Number: 15892140
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "001100"]

Abstract:
Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

Claim (Index 10):
A unimolecular nanoparticle comprising:\n a dendritic polymer core having a molecular weight of 500 to 120,000 Da and terminating in hydroxyl, amino or carboxylic acid groups; anionic polymers attached to at least a majority of the terminating groups of the dendritic polymer, wherein each anionic polymer comprises a polymeric backbone attached to weakly basic groups by a C 2 -C 12  heteroalkyl group comprising 1 to 4 nitrogen atoms and anionic functional groups, wherein the anionic functional groups are each conjugated to the polymeric backbone via a pH sensitive linker and optionally the C 2 -C 12  heteroalkyl group, the number of anionic groups per repeat unit of the anionic polymer ranges from 1-2 and the number of cationic groups per repeat unit of the anionic polymer ranges from 0 to 2, and each anionic polymer segment has a molecular weight from about 1,000 to about 10,000 Da; and poly(ethylene glycol) attached to a plurality of anionic polymers and having a terminal group selected from a targeting ligand, OH, O-alkyl, NH 2 , biotin, or a dye, wherein the terminal group of at least one poly(ethylene glycol) is having a molecular weight of about 1,000 to about 15,000 Da.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 88.0
- Lexical Diversity: 1.24138
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15555482', '15551995', '13516511', '15563533', '15383454']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7165972699152032
- 35 USC 102 Novelty (BERT): 0.5006261799874856
- Combined Prediction Score: 0.6950001609224314
- Mean Citation Score: 200.830826
- Max Citation Score: 225.31363
- Similarity Product: 149.58000188492775

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test