PATENT CLAIM ANALYSIS

Application Number: 15779038
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["536", "103000"]

Abstract:
The present application provides an improved process for the preparation of sugammadex which comprises the halogenation of γ-cyclodextrin in a suitable organic solvent to give 6-per-deoxy-6-per-halo-γ-cyclodextrin, wherein halo is bromo or chloro, reacting the halogenated γ-cyclodextrin with 3-mercaptopropionic acid in the presence of alkoxide base to obtain sugammadex of formula I. This application also provides isolation of 6-per-deoxy-6-per-chloro-γ-cyclodextrin as a crystalline compound and its use for the preparation of sugammadex of formula (I).

Claim (Index 1):
A process for preparing sugammadex of formula I, comprising,\n a) reacting \u03b3-cyclodextrin of formula II, \n with a halogenating agent, selected from oxalyl chloride, oxalyl bromide, thionyl chloride and thionyl bromide, in an organic solvent,\n b) mixing the reaction mixture of step a) with an aqueous solution of base and alcoholic solvent, \n c) isolating 6-per-deoxy-6-per-halo-\u03b3-cyclodextrin of compound of formula III, wherein X is bromide or chloride, \n d) optionally, drying the 6-per-deoxy-6-per-halo-\u03b3-cyclodextrin, e) optionally, purifying the compound of step c) or d), and f) reacting the 6-per-deoxy-6-per-halo-\u03b3-cyclodextrin with 3-mercaptopropionic acid in presence of alkali metal alkoxide base in an organic solvent to obtain sugammadex.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 93.0
- Lexical Diversity: 1.43636
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16087065', '15779040', '15580408', '13818658', '15873505']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6091671395168171
- 35 USC 102 Novelty (BERT): 0.5723574192718525
- Combined Prediction Score: 0.6054861674923206
- Mean Citation Score: 354.402894
- Max Citation Score: 460.62976
- Similarity Product: 412.6024843330383

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test