PATENT CLAIM ANALYSIS

Application Number: 15860356
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["435", "377000"]

Abstract:
The disclosure provides methods and compositions useful for obtaining induced stem cells, methods of making and use thereof.

Claim (Index 1):
A method comprising:\n contacting a somatic cell with an ectopic self-replicating RNA replicon comprising a plurality of non-structural replicase domains from an alphavirus and comprising polynucleotides encoding at least four de-differentiation factors selected from the group consisting of a (i) KLF4, (ii) OCT4, (iii) SOX2, (iv) c-MYC or n-MYC or L-MYC, (v) GLIS1 and (vi) NANOG, culturing the somatic cell to express the de-differentiation factor; selecting cells that display a stem cell morphology and/or stem cell markers; and subculturing the cells to obtain a population of induced stem cells.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.11111
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14402924', '13088009', '12743776', '13590880', '14311545']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6366647427262653
- 35 USC 102 Novelty (BERT): 0.7653678697745433
- Combined Prediction Score: 0.6495350554310931
- Mean Citation Score: 540.3153980000002
- Max Citation Score: 1017.5787
- Similarity Product: 898.0820359649421

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test