PATENT CLAIM ANALYSIS

Application Number: 16135240
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "018800"]

Abstract:
The present disclosure provides oleanoyl tripeptide to prevent skin aging. More specifically the invention discloses the anti-collagenase, anti-elastase, enhancement of TGF-β secretion in fibroblasts, UV protection, oxidative stress protection, and other properties of the oleanoyl-KVK tripeptide which aids in preventing skin aging.

Claim (Index 1):
A process for preparing a compound of structure 1 with SEQ ID #1 attached to oleanolic acid comprising the steps of:\n a. Treating Boc-Lys(Cbz)-OH, wherein both the amino groups of L-Lysine is protected, with Benzyl bromide in Acetone and potassium carbonate to get Boc-Lys(Cbz)-OBzl; b. Hydrolyzing the Boc-Lys(Cbz)-OBzl from step (a) to obtain H-Lys(Cbz)-OBzl-HCl; c. Coupling the H-Lys(Cbz)-OBzl-HCl of step (b) with Boc-Val-OH in the presence of N, N\u2032-Dicyclohexylcarbodiimide, Hydroxy benzotriazole and triethylamine to obtain Boc-Val-Lys(Cbz)-OBzl; d. Treating Boc-Val-Lys(Cbz)-OBzl obtained from step c) with trifluoroacetic acid to obtain H-Val-Lys(Cbz)-OBzl; e. Coupling H-Val-Lys(Cbz)-OBzl of step d) with Boc-Lys(Cbz)-OH in the presence of N, N\u2032-Dicyclohexylcarbodiimide, Hydroxy benzotriazole and triethylamine to obtain Boc-Lys(Bzl)-Val-Lys(Cbz)-OBzl; f. Treating Boc-Lys(Bzl)-Val-Lys(Cbz)-OBzl of step e) with trifluoroacetic acid to obtain H-Lys(Bzl)-Val-Lys(Cbz)-OBzl; g. Coupling the H-Lys(Bzl)-Val-Lys(Cbz)-OBzl of above step with 3-O-acetyl Oleanoyl chloride (synthesized from 3-O-acetyl oleanolic acid and thionyl chloride) in the presence of triethylamine to get (3-O-Acetyl Oleanoyl)-Lys(Bzl)-Val-Lys(Cbz)-OBzl; h. Hydrogenating the (3-O-Acetyl Oleanoyl)-Lys(Bzl)-Val-Lys(Cbz)-OBzl of step g) in the presence of palladium and carbon catalyst in alcohol medium to get 3-O-Acetyl Oleanoyl-Lys-Val-Lys; i. Hydrolyzing the acetyl group using a base in alcohol medium to obtain a tripeptide of SEQ ID#1, linked to oleanolic acid,\n wherein SEQ ID #1 is K\u2014V\u2014K, and structure 1 is represented as below

Metadata:
- Claim Count in Document: 3.0
- Percentile: 97.0
- Lexical Diversity: 1.36111
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14800627', '13166836', '12979667', '15442229', '13522663']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7333214760062011
- 35 USC 102 Novelty (BERT): 0.5037634325730459
- Combined Prediction Score: 0.7103656716628856
- Mean Citation Score: 210.246738
- Max Citation Score: 214.83693
- Similarity Product: 131.43120570432544

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test