PATENT CLAIM ANALYSIS

Application Number: 15969328
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["546", "192000"]

Abstract:
Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

Claim (Index 2):
A method for monitoring the response of a patient having a disease or condition characterized by amyloid deposit to a treatment, comprising:\n (i) forming a detectable complex following the treatment by contacting an effective amount of a compound of Formula Ic, or a salt or solvate thereof, or a pharmaceutical composition thereof, with a sample, a body part, or a body area of the patient; and (ii) detecting the formation of the detectable complex, wherein a decrease of detectable complex as compared to before the treatment indicates that the patient is responsive to the treatment; wherein the compound of Formula Ic has the structure: wherein\n EDG is heterocycloalkyl of no more than 10 carbons optionally substituted with one or more R 17 ; each R 17  is independently halogen, \u2014OR 18 , \u2014NR 19 R 20 , C 1 -C 10  alkyl, or C 1 -C 10  heteroalkyl; each of R 18 , R 19  and R 20  is independently hydrogen, C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl, or cycloalkyl of no more than 10 carbon atoms, each of which except for hydrogen is optionally substituted with one or more R 21 ; \n each R 21  is independently halogen, \u2014OR 22 , \u2014NR 23 R 24 , C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl, cycloalkyl of no more than 10 carbon atoms, heterocycloalkyl of no more than 10 carbon atoms, aryl of no more than 10 carbon atoms, or heteroaryl of no more than 10 carbon atoms; \n each of R 22 , R 23  and R 24  is independently hydrogen or C 1 -C 10  alkyl; \n Ar is arylene of no more than 14 carbon atoms optionally substituted with one or more R 1 ;\n each R 1  is independently halogen, \u2014OR 2 , \u2014NR 3 R 4 , C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl; \n each of R 2 , R 3  and R 4  is independently hydrogen, C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl; \n R 84  is hydrogen or C 1 -C 10  alkyl; EWG is halogen, \u2014CN, \u2014NO 2 , or methyl; WSG is: wherein n is an integer from 2-50, and R 81  is hydrogen, a C 1 -C 10  alkyl, a C 2 -C 10  alkenyl, or a C 2 -C 10  alkynyl, wherein the alkyl, alkenyl, or alkynyl is optionally substituted with one or more C 1 -C 10  alkyl, C 1 -C 10  heteroalkyl, cycloalkyl of no more than 10 carbon atoms, heterocycloalkyl of no more than 10 carbon atoms, aryl of no more than 10 carbon atoms, or heteroaryl of no more than 10 carbon atoms; each R 82  is independently hydrogen or C 1 -C 10  alkyl; X is C\u2550O or SO 2 ; and Y is NH or S.

Metadata:
- Claim Count in Document: 48.0
- Percentile: 93.0
- Lexical Diversity: 1.4878
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14915883', '14572465', '14670088', '14507509', '16066285']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7575036309617462
- 35 USC 102 Novelty (BERT): 0.5822075357400366
- Combined Prediction Score: 0.7399740214395754
- Mean Citation Score: 368.946308
- Max Citation Score: 654.9379
- Similarity Product: 367.6794800848901

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test