PATENT CLAIM ANALYSIS

Application Number: 16018496
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["514", "210210"]

Abstract:
The present inventions include a method of inhibiting COMT enzyme in a subject as well as compounds of formula I, or a pharmaceutically acceptable salt thereof, that are useful in the treatment of various disorders mediated by COMT, including Parkinson's disease and/or schizophrenia.

Claim (Index 1):
A method of treating or preventing a neurological or psychiatric disorder, or treating symptoms associated with a neurological or psychiatric disorder, comprising administering to a subject in need thereof an effective amount of a COMT-inhibiting compound in accordance with formula I, or a pharmaceutically acceptable salt thereof, wherein: X is selected from hydrogen, halogen, C\u2261N, CF 3 , and C 1 -C 4  alkyl; Z is selected from SO 2 R 1  and SO 2 NR 2 R 3 ; R 1  is selected from C 1 -C 10  alkyl, C 3 -C 10  cycloalkyl, aryl, aralkyl, heterocyclyl, heteroaryl and heteroarylalkyl, any of which may be substituted with one or more groups selected from halogen, C\u2261N, CF 3 , OH, C 1 -C 4  alkyl or C 2 -C 4  alkenyl, alkoxy, nitro, amino, C 1 -C 4  alkylamino, oxo, C 3 -C 10  cycloalkyl, acyl, aryl, aralkyl, heterocyclyl, heteroaryl, CON(R) 2 , SO 2 R, or SO 2 N(R) 2 , where each R is independently C 1 -C 4  alkyl or (R) 2  forms a carbocyclic ring; R 2  and R 3  are independently selected from hydrogen and any of the groups as defined for R 1 , with the proviso that at least one of R 2  or R 3  is different from hydrogen; or R 2  and R 3  may together form a 3-10 membered monocyclic, bicyclic or spirocyclic nitrogen-containing ring system that contains 0-3 (preferably 0-1) additional heteroatoms selected from oxygen (O), nitrogen (N), and sulfur (S), and which may be further substituted with one or more groups selected from halogen, C\u2261N, CF 3 , OH, C 1 -C 4  alkyl or C 2 -C 4  alkenyl, C 3 -C 6  cycloalkyl, alkoxy, nitro, amino, C 1 -C 4  alkoxycarbonyl, acyl, C 1 -C 4  alkylamino, oxo, SO 2 CH 3 , aryl, aralkyl, heterocyclyl, heteroaryl or heteroarylalkyl; with the proviso that when X is hydrogen and Z is SO 2 R 1 , R 1  is not C 4  alkyl, C 8  alkyl, tetrahydropyran or propylcyclopropane; or when X is H and Z is SO 2 NR 2 R 3 , R 2  and R 3  do not together form a 1-piperidinyl ring substituted with a \u03b1-methyl group; or when X is Cl and Z is SO 2 R 1 , R 1  is not C 3  alkyl, C 4  alkyl or C 5 -C 6  cycloalkyl; or when X is Cl and Z is SO 2 NR 2 R 3 , R 2  and R 3  do not together form an unsubstituted, 1-pyrrolidinyl ring.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 94.0
- Lexical Diversity: 1.23077
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15011353', '15011365', '15458534', '11015348', '14097808']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7840694085792886
- 35 USC 102 Novelty (BERT): 0.587697968324311
- Combined Prediction Score: 0.7644322645537909
- Mean Citation Score: 363.848216
- Max Citation Score: 524.0887
- Similarity Product: 404.6007012933612

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test