PATENT CLAIM ANALYSIS

Application Number: 16072596
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["544", "398000"]

Abstract:
The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.

Claim (Index 1):
A method for preparing 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine, said method comprising the steps of\n a. providing piperazine; b. providing an electrophile selected from the group consisting of 1, 2-di-fluorobenzene, 2-chloro-fluorobenzene, 1, 2-di-chlorobenzene, 2-(2,4-di-methyl-thiophenol-yl)-chlorobenzene, and 2-(2,4-di-methyl-thiophenol-yl)-fluorobenzene; c. providing a base having a pKa above 29 in DMSO and/or a pKa above 25 in THF; d. providing an organic solvent that only contain protons with a pKa above 32 in DMSO; e. reacting said piperazine with said electrophile in said organic solvent in the presence of the base and in the absence of a transition metal catalyst, thereby obtaining i. 1-[2-fluoro-phenyl]piperazine or 1-[2-chloro-phenyl]piperazine; or ii. 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine, f. if obtaining 1-[2-fluoro-phenyl]piperazine or 1-[2-chloro-phenyl]piperazine in step e. reacting said 1-[2-fluoro-phenyl]piperazine or 1-[2-chloro-phenyl]piperazine with 1-sulfanyl-2,4-dimethyl-benzene, thereby obtaining 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine; g. optionally purifying the 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine; wherein steps a., b., c. and d. is performed in any order.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 95.0
- Lexical Diversity: 1.08333
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14767350', '15315182', '14370322', '14264373', '10497615']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7355618054328685
- 35 USC 102 Novelty (BERT): 0.4880476969320173
- Combined Prediction Score: 0.7108103945827834
- Mean Citation Score: 205.31431000000003
- Max Citation Score: 243.30994
- Similarity Product: 191.891048176862

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test