PATENT CLAIM ANALYSIS

Application Number: 15946774
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["530", "391900"]

Abstract:
Provided are antibody drug conjugates that bind PRLR, in particular human PRLR, their methods of making, and uses thereof.

Claim (Index 12):
An antibody-drug conjugate (ADC) comprising the structure of Formula (IX) or a salt thereof, wherein D comprises a pyrrolobenzodiazepine (PBD) dimer; Ab is an anti-prolactin receptor (PRLR) antibody, Y is Val, Z is Ala, and q is 1, 2, 3, 4, 5, 6, 7, or 8, and wherein the anti-PRLR antibody comprises: i. a heavy chain variable region comprising a CDRH1 sequence comprising SEQ ID NO: 3, a CDRH2 sequence comprising SEQ ID NO: 4, and a CDRH3 sequence comprising SEQ ID NO: 5; ii. a light chain variable region comprising a CDRL1 sequence comprising SEQ ID NO: 8, a CDRL2 sequence comprising SEQ ID NO: 9, and a CDRL3 sequence comprising SEQ ID NO: 10; iii. a mutation comprising S239C in a heavy chain constant region, wherein the numbering is in accordance with Kabat; and iv. wherein n is about 2.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 91.0
- Lexical Diversity: 1.15
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15363786', '15363715', '14928738', '15819153', '15349692']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7308386257545602
- 35 USC 102 Novelty (BERT): 0.5559586237692544
- Combined Prediction Score: 0.7133506255560297
- Mean Citation Score: 419.718152
- Max Citation Score: 457.7913
- Similarity Product: 341.1865599974692

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test