PATENT CLAIM ANALYSIS

Application Number: 15936210
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["424", "093210"]

Abstract:
Disclosed herein are methods and compositions for modifying TCR genes, using nucleases (zinc finger nucleases or TAL nucleases) to modify TCR genes.

Claim (Index 1):
An isolated T-lymphocyte comprising a stably integrated exogenous sequence encoding a T-cell receptor (TCR), wherein at least one endogenous TCR gene within the cell is inactivated by a pair of zinc finger nucleases, each zinc finger nuclease comprising a zinc finger protein that binds to a target sequence in an exon of the TCR gene and an engineered cleavage half-domain.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 90.0
- Lexical Diversity: 1.18182
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14221074', '14591625', '12927292', '14589632', '15380723']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7634018046953325
- 35 USC 102 Novelty (BERT): 0.65214989273594
- Combined Prediction Score: 0.7522766134993932
- Mean Citation Score: 547.839648
- Max Citation Score: 741.4657599999997
- Similarity Product: 562.4016757209395

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test