PATENT CLAIM ANALYSIS

Application Number: 15747141
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["530", "308000"]

Abstract:
Provided is a method of preparing a physiologically active polypeptide conjugate, in which a physiologically active polypeptide and a non-peptidyl polymer are linked to each other via a covalent bond. The method is to improve an overall yield of the physiologically active polypeptide conjugate by improving a reaction of the non-peptidyl polymer and the physiologically active polypeptide, and particularly, the method is to prepare a physiologically active polypeptide conjugate in a high yield by performing a two-step reaction through selective precipitation. The preparation method of the present invention is used to produce a non-peptidyl polymer-physiologically active polypeptide conjugate and a physiologically active polypeptide-physiologically active carrier conjugate in a high yield, and therefore, the method may be used in the development of long-acting formulations of various peptide drugs which maintain in vivo activity at a relatively high level and have remarkably increased blood half-life.

Claim (Index 12):
The method of  claim 11 , wherein the exendin derivative is selected from the group consisting of des-amino-histidyl(DA)-exendin-4, beta-hydroxy-imidazo-propionyl(HY)-exendin-4, imidazo-acetyl(CA)-exendin-4, and dimethyl-histidyl(DM)-exendin-4.

Metadata:
- Claim Count in Document: 57.0
- Percentile: 86.0
- Lexical Diversity: 2.15714
- Patent Class: 530.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13255199', '14772493', '14873321', '13055406', '12523050']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.750594490914366
- 35 USC 102 Novelty (BERT): 0.5738135636209085
- Combined Prediction Score: 0.7329163981850203
- Mean Citation Score: 423.79347
- Max Citation Score: 567.0242
- Similarity Product: 340.05413164691925

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test