PATENT CLAIM ANALYSIS

Application Number: 15761995
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-09
Patent Classification: ["514", "210180"]

Abstract:
Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

Claim (Index 1):
A method for treating, preventing, or ameliorating a condition, disorder, or disease mediated by a BMX, BTK, PIK3C, PIK3D, ITK, TEC, or TXK kinase in a subject, comprising administering to the subject a therapeutically effective amount of a compound of Formula II: or a single enantiomer, a racemic mixture, a mixture of diastereomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or prodrug thereof; wherein:\n R 1  is \u2014C(O)CR 1e \u2550CR 1f CR 1g , \n \u2014N 1a C(O)CR 1e \u2550CR 1f CR 1g , \u2014S(O)CR 1e \u2550CR 1f CR 1g , \u2014S(O 2 )CR 1e \u2550CR 1f CR 1g , \u2014NR 1a S(O)CR 1e \u2550CR 1f CR 1g , \u2014NR 1a S(O 2 )CR 1e \u2550CR 1f CR 1g , or R 2  is C 3-10  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, or heterocyclyl; R 2A  is hydrogen, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, or heterocyclyl; L 1  is a bond, \u2014O\u2014, \u2014S\u2014, \u2014N(R 1A )\u2014, or \u2014C(R 1A R 1B )\u2014, wherein each R 1A  and RIB is independently hydrogen, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, or heterocyclyl; L 2  is C 3-10  cycloalkylene, C 6-14  arylene, C 7-15  aralkylene, heteroarylene, or heterocyclylene; T is a bond, \u2014O\u2014, \u2014S\u2014, \u2014N\u2550, \u2014N(R 4 )\u2014, or \u2014C(R 4 )\u2550; U is a bond, \u2014O\u2014, \u2014S\u2014, \u2014N\u2550, \u2014N(R 5 )\u2014, or \u2014C(R 5 )\u2550; V is a bond, \u2014O\u2014, \u2014S\u2014, \u2014N\u2550, \u2014N(R 6 )\u2014, or \u2014C(R 6 )\u2550; W is a bond, \u2014O\u2014, \u2014S\u2014, \u2014N\u2550, \u2014N(R 7 )\u2014, or \u2014C(R 7 )\u2550; X and Y are each independently C or N; each R 4 , R 5 , R 6 , and R 7  is independently (a) hydrogen, cyano, halo, or nitro; (b) C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-10  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, or heterocyclyl; or (c) \u2014C(O)R 1a , \u2014C(O)OR 1a , \u2014C(O)NR 1b R 1c , \u2014C(NR 1a )NR 1b R 1c , \u2014OR 1a , \u2014OC(O)R 1a , \u2014OC(O)OR 1a , \u2014OC(O)NR 1b R 1c , \u2014OC(\u2550NR 1a )NR 1b R 1c , \u2014OS(O)R 1a , \u2014OS(O) 2 R 1a , \u2014OS(O)NR 1b R 1c , \u2014OS(O) 2 NR 1b R 1c , \u2014NR 1b R 1c , \u2014NR 1a C(O)R 1d , \u2014NR 1a C(O)OR 1d , \u2014NR 1a C(O)NR 1b R 1c , \u2014NR 1a C(\u2550NR 1d )NR 1b R 1c , \u2014NR 1a S(O)R 1d , \u2014NR 1a S(O) 2 R 1d , \u2014NR 1a S(O)NR 1b R 1c , \u2014NR 1a S(O) 2 NR 1b R 1c , \u2014SR 1a , \u2014S(O)R 1a , \u2014S(O) 2 R 1a , \u2014S(O)NR 1b R 1c , or \u2014S(O) 2 NR 1b R 1c ; or R 4  and R 5 , R 5  and R 6 , or R 6  and R 7  are linked together to form C 3-7  cycloalkyl, C 6-14  aryl, heteroaryl, or heterocyclyl; each R 1a , R 1b , R 1c , and R 1d  is independently hydrogen, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, or heterocyclyl; or R 1a  and R 1c  together with the C and N atoms to which they are attached form heterocyclyl; or R 1b  and R 1c  together with the N atom to which they are attached form heterocyclyl; and each R 1e , R 1f , and R 1g  is independently hydrogen, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, or heterocyclyl; with the proviso that no more than one of T, U, V, and W is a bond; wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylene, aryl, arylene, aralkyl, aralkylene, heteroaryl, heteroarylene, heterocyclyl, and heterocyclylene is optionally substituted with one or more, in one embodiment, one, two, three, or four, substituents Q, where each Q is independently selected from (a) oxo, cyano, halo, and nitro; (b) C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, and heterocyclyl, each of which is further optionally substituted with one or more, in one embodiment, one, two, three, or four, substituents Q a ; and (c) \u2014C(O)R a , \u2014C(O)OR a , \u2014C(O)NR b R c , \u2014C(NR a )NR b R c , \u2014OR a , \u2014OC(O)R a , \u2014OC(O)OR a , \u2014OC(O)NR b R c , \u2014OC(\u2550NR a )NR b R c , \u2014OP(O)(OR a ) 2 , \u2014OS(O)R a , \u2014OS(O) 2 R a , \u2014OS(O)NR b R c , \u2014OS(O) 2 NR b R c , \u2014NR b R c , \u2014NR a C(O)R d , \u2014NR a C(O)OR d , \u2014NR a C(O)NR b R c , \u2014NR a C(\u2550NR d )NR b R c , \u2014NR a S(O)R d , \u2014NR a S(O) 2 R d , \u2014NR a S(O)NR b R c , \u2014NR a S(O) 2 NR b R c , \u2014SR a , \u2014S(O)R a , \u2014S(O) 2 R a , \u2014S(O)NR b R c , and \u2014S(O) 2 NR b R c , wherein each R a , R b , R c , and R d  is independently (i) hydrogen; (ii) C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, or heterocyclyl, each of which is optionally substituted with one or more, in one embodiment, one, two, three, or four, substituents Q a ; or (iii) R b  and R c  together with the N atom to which they are attached form heterocyclyl, optionally substituted with one or more, in one embodiment, one, two, three, or four, substituents Q a ; wherein each Q a  is independently selected from the group consisting of (a) oxo, cyano, halo, and nitro; (b) C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, and heterocyclyl; and (c) \u2014C(O)R f , \u2014C(O)OR f , \u2014C(O)NR g R h , \u2014C(NR f )NR g R h , \u2014OR f , \u2014OC(O)R f , \u2014OC(O)OR f , \u2014OC(O)NR g R h , \u2014OC(\u2550NR f )NR g R h , \u2014OP(O)(OR f ) 2 , \u2014OS(O)R f , \u2014OS(O) 2 R f , \u2014OS(O)NR g R h , \u2014OS(O) 2 NR g R h , \u2014NR g R h , \u2014NR f C(O)R k , \u2014NR f C(O)OR k , \u2014NR f C(O)NR g R h , \u2014NR f C(\u2550NR k )NR g R h , \u2014NR f S(O)R k , \u2014NR f S(O) 2 R k , \u2014NR f S(O)NR g R h , \u2014NR f S(O) 2 NR g R h , \u2014SR f , \u2014S(O)R f , \u2014S(O) 2 R f , \u2014S(O)NR g R h , and \u2014S(O) 2 NR g R h ; wherein each R f , R g , R h , and R k  is independently (i) hydrogen; (ii) C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-7  cycloalkyl, C 6-14  aryl, C 7-15  aralkyl, heteroaryl, or heterocyclyl; or (iii) R g  and R h  together with the N atom to which they are attached form heterocyclyl.

Metadata:
- Claim Count in Document: 86.0
- Percentile: 96.0
- Lexical Diversity: 2.025
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15127000', '16005490', '14489231', '13431716', '13830712']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.79010656684211
- 35 USC 102 Novelty (BERT): 0.5742901604488322
- Combined Prediction Score: 0.7685249262027822
- Mean Citation Score: 435.272624
- Max Citation Score: 474.12836
- Similarity Product: 382.1648355022882

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test