PATENT CLAIM ANALYSIS

Application Number: 16153193
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["514", "619000"]

Abstract:
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Claim (Index 2):
The method according to  claim 1 , wherein the compound is represented by the structure of formula III: wherein\n Z is NO 2  or CN; \n Y is CF 3 , F, I, Br, Cl, or CN; \n R 2  is hydrogen, C 1 -C 12 -alkyl, \u2014SO 2 -aryl, \u2014SO 2 -phenyl, \u2014CO-aryl, arylalkyl, benzyl, aryl, or C 3 -C 7 -cycloalkyl; \n Q 1  is substituted or unsubstituted aryl, substituted or unsubstituted phenyl, substituted or unsubstituted arylalkyl, F, Cl, Br, I, CF 3 , CN, NO 2 , or substituted or unsubstituted heterocycloalkyl; \n Q 2  is hydrogen, substituted aryl, substituted phenyl, F, Cl, Br, I, CF 3 , CN, NO 2 , substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted arylalkyl; \n Q 3  is hydrogen, substituted aryl, substituted phenyl, F, Cl, Br, I, CF 3 , CN, NO 2 , substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted arylalkyl; \n wherein at least one of Q 1 , Q 2  and Q 3  is a substituted aryl, substituted phenyl, or substituted or unsubstituted arylalkyl; or \n Q 1  and Q 2  are joined together to form a substituted or unsubstituted C 5 -C 8  carbocyclic or heterocyclic ring and Q 3  is as defined above; or \n Q 2  and Q 3  are joined together to form a substituted or unsubstituted C 5 -C 8  non-aromatic carbocyclic or a heterocyclic ring and Q 1  is as defined above; and \n wherein said formed carbocyclic or heterocyclic ring is not dihydropyridin-2(1H)-one, pyridin-2(1H)-one or 1H-pyrrole; \n or its optical isomer, its racemic mixture, pharmaceutically acceptable salt, pharmaceutical product, polymorph, hydrate, or any combination thereof.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.42647
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15135151', '15331751', '15981636', '15135334', '15222734']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8967688440374004
- 35 USC 102 Novelty (BERT): 0.727901905565824
- Combined Prediction Score: 0.8798821501902429
- Mean Citation Score: 793.601892
- Max Citation Score: 854.0647
- Similarity Product: 793.8311842213692

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test