PATENT CLAIM ANALYSIS

Application Number: 16091577
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["549", "467000"]

Abstract:
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Claim (Index 57):
The compound according to  claim 39  which is:\n (2R*,3R*)\u2014N 5 -Cyclobutyl-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R*,3S*)\u2014N 5 -cyclobutyl-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n N 5 -(2-Hydroxypropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n N 5 -Cyclopropyl-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n N 5 ,N 7 ,2-Trimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-Hydroxypropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -(2-hydroxypropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -Cyclopropyl-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -cyclopropyl-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)\u2014N 5 -Cyclopropyl-2-(hydroxymethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)\u2014N 5 -Cyclobutyl-2-(hydroxymethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)-2-(Hydroxymethyl)-N 7 -methyl-3-phenyl-N 5 -propyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)-2-(Hydroxymethyl)-N 7 -methyl-3-phenyl-N 5 -(2-(piperidin-4-yl)ethyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)-2-(Hydroxymethyl)-N 7 -methyl-N 5 -(3-(4-methylpiperazin-1-yl)propyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide;  15 \n (2S*,3S*)-2-(Hydroxymethyl)-N 7 -methyl-3-phenyl-N 5 -(3-(piperazin-1-yl)propyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -Cyclopropyl-2-(hydroxymethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R*,3S*)\u2014N 7 ,2-Dimethyl-3-phenyl-N 5 -(3-(piperidin-4-yl)propyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-Dimethyl-3-phenyl-N 5 -(3-(piperidin-4-yl)propyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -Ethyl-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 ,N 7 ,2-Trimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1S*,2S*)-2-(Hydroxymethyl)cyclopropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)\u2014N 5 -Cyclopropyl-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -Cyclopropyl-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 ,N 7 -dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-N 5 4(1S ,2S)-2-methylcyclopropyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1S ,25)-2-(Hydroxymethyl)cyclopropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1R,2R)-2-(hydroxymethyl)cyclopropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)\u2014N 5 -Cyclopropyl-2-(hydroxymethyl)-3-(3-methoxyphenyl)-N 7 -methyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)-2-(Hydroxymethyl)-3-(3-methoxyphenyl)-N 7 -methyl-N 5 4(1S,2S)-2-methylcyclopropyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide;  32 \n (2S*,3S*)-2-(Hydroxymethyl)-3-(3-methoxyphenyl)-N 5 ,N 7 -dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)\u2014N 5 -Ethyl-2-(hydroxymethyl)-3-(3-methoxyphenyl)-N 7 -methyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)-2-(Hydroxymethyl)-N 5 -(2-methoxyethyl)-3-(3-methoxyphenyl)-N 7 -methyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-Methoxyethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-Dimethyl-3-phenyl-N 5 -(tetrahydro-2H-pyran-4-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-hydroxyethyl)-N 7 ,2-Dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (1R,5S,6S)-tert-Butyl 6-((2R,3S)-2-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)-3-azabicyclo[3.1.0]hexane-3-carboxylate; \n (2R,3S)\u2014N 5 -((1R,5S,6s)-3-Azabicyclo[3.1.0]hexan-6-yl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1R,5S,6s)-3-Acetyl-3-azabicyclo[3.1.0]hexan-6-yl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1R,5S,6R)-3-Oxabicyclo[3.1.0]hexan-6-yl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-(Dimethylamino)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(3-(Dimethylamino)propyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R*,3S*)\u2014N 5 -Cyclopropyl-3-(3-methoxyphenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-Dimethyl-N 5 -(oxetan-3-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n tert-Butyl 2-(2-((2R,3S)-2-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)ethyl)morpholine-4-carboxylate;  47 \n (2R,3S)\u2014N 7 ,2-Dimethyl-N 5 -(2-(morpholin-2-yl)ethyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(3-hydroxypropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-dimethyl-N 5 -(3-morpholinopropyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(3-methoxypropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-dimethyl-3-phenyl-N 5 -(tetrahydrofuran-3-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2,2-difluoroethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n tert-Butyl 2-(3-((2R,3S)-2-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)propyl)morpholine-4-carboxylate; \n (2R,3S)\u2014N 7 ,2-Dimethyl-N 5 -(3-(morpholin-2-yl)propyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -ethyl-3-(3-methoxyphenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1R,2R)-2-(Hydroxymethyl)cyclopropyl)-3-(3-methoxyphenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 4(1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-3-(3-methoxyphenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (R)-tert-Butyl 2-(3-((2R,3S)-3-(3-methoxyphenyl)-2-methyl-7-(methylcarbamoyl)-2,3-dihydrobenzofuran-5-carboxamido)propyl)morpholine-4-carboxylate; \n (2R,3S)-3-(3-Methoxyphenyl)-N 7 ,2-dimethyl-N 5 -(34(R)-morpholin-2-yl)propyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)-3-(3-Methoxyphenyl)-N 7 ,2-dimethyl-N 5 -(34(S)-morpholin-2-yl)propyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n tert-Butyl 3-fluoro-3-(3-((2R,3S)-2-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)propyl)piperidine-1-carboxylate; \n (2R,3S)\u2014N 5 -(3-(3-Fluoropiperidin-3-yl)propyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1S*,2R*)-2-(2-Hydroxyethyl)cyclopropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-Dimethyl-N 5 -((1S*,2S*)-2-(2-morpholinoethyl)cyclopropyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-Dimethyl-N 5 -((1S,2S)-2-(2-morpholinoethyl)cyclopropyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-dimethyl-N 5 -((1R,2R)-2-(2-morpholinoethyl)cyclopropyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R*,3S*)-3-(3-(2-Hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-N 5 -((1S,2S)-2-methylcyclopropyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (S)-tert-Butyl 3-fluoro-3-(3-((2R*,3S*)-3-(3-(2-hydroxyethoxy)phenyl)-2-methyl-7-(methylcarbamoyl)-2,3-dihydrobenzofuran-5-carboxamido)propyl)piperidine-1-carboxylate; \n (2R*,3S*)\u2014N 5 -(3-((R)-3-Fluoropiperidin-3-yl)propyl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (R)-tert-Butyl 3-fluoro-3-(2-((2S,3S)-2-(fluoromethyl)-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)ethyl)piperidine-1-carboxylate; \n (2S,3S)-2-(Fluoromethyl)-N 5 -(2-((R)-3-fluoropiperidin-3-yl)ethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 -(3-((R)-3-fluoropiperidin-3-yl)propyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (R)-tert-Butyl 3-fluoro-3-(2-((2R,3S)-2-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)ethyl)piperidine-1-carboxylate; \n (2R,3S)\u2014N 5 -(2-((R)-3-Fluoropiperidin-3-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (R)-tert-Butyl 2-(3-((2S,3S)-2-(fluoromethyl)-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)propyl)morpholine-4-carboxylate; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-N 5 -(3-((R)-morpholin-2-yl)propyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide;  77 \n (2R*,3S*)\u2014N 5 -((1R,5S,6R)-3-Oxabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (R)-tert-Butyl 2-(2-((2S,3S)-2-(fluoromethyl)-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)ethyl)morpholine-4-carboxylate; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-N 5 -(2-((R)-morpholin-2-yl)ethyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-(4,4-Difluoropiperidin-3-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n tert-Butyl 4,4-difluoro-3-(2-((2R,3S)-2-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)ethyl)piperidine-1-carboxylate; \n (2R,3S)\u2014N 5 -(2-(3,3-Difluoropiperidin-4-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n tert-Butyl 3,3-difluoro-4-(2-((2R,3S)-2-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)ethyl)piperidine-1-carboxylate; \n (2S*,3S*)-2-(Fluoromethyl)-N 5 -((1R,4S)-4-hydroxycyclohexyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1R,5S,6R)-3-Oxabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S*,3S*)-2-(Fluoromethyl)-N 5 -((1R,3S)-3-hydroxycyclobutyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 -((1R,2R)-2-(hydroxymethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -((1R,5S,6S)-3-azabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (1R,5S,6S)-tert-butyl 6-((2S,3S)-2-(fluoromethyl)-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)-3-azabicyclo[3.1.0]hexane-3-carboxylate; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(tetrahydrofuran-3-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 -(2-hydroxyethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide;  92 \n (2S*,3S*)\u2014N 5 -((1R,5S,6S)-3-Acetyl-3-azabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)-3-(3-(2-Hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-N 5 -(2-(pyridin-3-yl)ethyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R*,3S*)\u2014N 5 -((1R,5S,6S)-3-Acetyl-3-azabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R*,3S*)\u2014N 5 -((1R,5S,6S)-3-azabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (1R,5S,6S)-tert-Butyl 6-((2R*,3S*)-3-(3-(2-hydroxyethoxy)phenyl)-2-methyl-7-(methylcarbamoyl)-2,3-dihydrobenzofuran-5-carboxamido)-3-azabicyclo[3.1.0]hexane-3-carboxylate; \n (R)-tert-Butyl 3-fluoro-3-(2-((2S,3S)-2-(fluoromethyl)-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)ethyl)piperidine-1-carboxylate; \n (2S,3S)-2-(Fluoromethyl)-N 5 -(2-((R)-3-fluoropiperidin-3-yl)ethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 7 ,2-dimethyl-3-phenyl-N 5 -(3-(piperidin-4-yl)propyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 ,N 7 ,2-trimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -ethyl-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -cyclopropyl-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)\u2014N 5 -cyclopropyl-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)\u2014N 5 -cyclopropyl-2-(hydroxymethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)\u2014N 5 -((1R,5S,6R)-3-oxabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)\u2014N 5 -cyclopropyl-2-(hydroxymethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -(2-hydroxypropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -(2-hydroxypropyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-N 5 -(2-(4,4-difluoropiperidin-3-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide (diastereomeric mixture); \n (2S,3S)-2-(Fluoromethyl)-N 5 -((1r,4S)-4-hydroxycyclohexyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamidedicarboxamide; \n (2R,3S)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 -((1r,3S)-3-hydroxycyclobutyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(tetrahydrofuran-3-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide (mix of diastereomers); \n (2S,3S)-2-(Fluoromethyl)-N 5 -(2-hydroxyethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-N 5 -((1R,5S,6s)-3-acetyl-3-azabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-N 5 -(2-(pyridin-3-yl)ethyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-N 5 -(1-methyl-1H-pyrazol-4-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-N 5 -(1-methyl-1H-pyrazol-4-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(1H-pyrazol-4-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(1H-pyrazol-4-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N 7 -trideuteromethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-N 5 -(2-(1H-pyrazol-4-yl)ethyl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-N 5 ((1-methyl-1H-pyrazol-4-yl)methyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-N 5 -(2(1-methyl-1H-pyrazol-4-yl)ethyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 -((1R,2R)-2-(hydroxymethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-((R*)-4,4-difluoropiperidin-3-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-((S*)-4,4-difluoropiperidin-3-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 -((1R,2R)-2-(hydroxymethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 -((trans)-2-(2-hydroxyethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-N 5 -(2-(4H-1,2,4-triazol-4-yl)ethyl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-N 5 -(oxetan-3-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(2-(pyridin-4-yl)ethyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-N 5 -(1-(methylsulfonyl)azetidin-3-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(2-(pyridin-3-yl)ethyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-N 5 -(2-(1H-imidazol-4-yl)ethyl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(2-(pyridin-3-yl)ethyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 5 -(2-methoxycyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide (mix of diastereomers); \n (Trans) tert-butyl 3,3-difluoro-4-(2-2-(fluoromethyl)-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)ethyl)piperidine-1-carboxylate (mix of diastereomers); \n (Trans) tert-butyl 3,3-difluoro-4-(3-2-(fluoromethyl)-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxamido)propyl)piperidine-1-carboxylate (mix of diastereomers); \n (Trans)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -((tetrahydrofuran-3-yl)methyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide (mix of diastereomers); \n (Trans)(2R,3S)\u2014N 5 -(2-(3,3-difluoropiperidin-4-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide (mix of diastereomers); \n (Trans) 2-(fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(2-(pyridin-2-yl)ethyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-((R*)-3,3-difluoropiperidin-4-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-((S*)-3,3-difluoropiperidin-4-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans) N 7 ,2-dimethyl-N 5 -(1-methyl-1H-pyrazol-4-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-N 7 ,2-dimethyl-N 5 -(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 5 -((trans)-2-(2-hydroxyethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 5 -((1R,2S)-2-(2-hydroxyethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 7 ,2-dimethyl-N 5 -(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1R,5S,6r)-3,3-difluorobicyclo[3.1.0]hexan-6-yl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 7 ,2-dimethyl-N 5 -(1-methyl-1H-pyrazol-4-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-((S*)-4,4-difluoropiperidin-3-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(2-((R*)-4,4-difluoropiperidin-3-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -(2-((S*)-4,4-difluoropiperidin-3-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -(2-((R*)-4,4-difluoropiperidin-3-yl)ethyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 -((1S,2S)-2-(hydroxymethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -((1R,5S,6s)-3-propionyl-3-azabicyclo[3.1.0]hexan-6-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-N 5 -((1R,5S,6r)-3-Oxabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-methoxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(3-((S*)-3,3-difluoropiperidin-4-yl)propyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -(3-((R*)-3,3-difluoropiperidin-4-yl)propyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(Fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -((1R,5S,6s)-3-propionyl-3-azabicyclo[3.1.0]hexan-6-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-N 5 -(1-methyl-1H-1,2,4-triazol-3-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -(3-((2r,5S)-5-Amino-1,3-dioxan-2-yl)propyl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-N 5 -(1-methyl-1H-1,2,3-triazol-4-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -(2-((2r,5S)-5-amino-1,3-dioxan-2-yl)ethyl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(pyridazin-4-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-methoxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-N 5 -(4-methyl-4H-1,2,4-triazol-3-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N 7 -ethyl-2-(fluoromethyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-N 5 -(2-methyl-2H-tetrazol-5-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)\u2014N 5 -((1R,5S,6 r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N 7 -cyclopropyl-2-(fluoromethyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3S)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-N 5 -((1R,5S,6r)-3,3-difluorobicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N7-methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-N 5 -((trans)-2-(2-morpholinoethyl)cyclopropyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (Trans)-2-(fluoromethyl)-N 7 -methyl-N 5 -(1S,2S)-2-methylcyclopropyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(pyrimidin-5-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide dicarboxamide; \n (2S,3R)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)-3-(3-(2-hydroxyethoxy)phenyl)-N 7 ,2-dimethyl-N 5 -(2-(pyridin-3-yl)ethyl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(fluoromethyl)-N 5 -((1R,2R)-2-(hydroxymethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(1H-pyrazol-4-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(fluoromethyl)-N 7 -methyl-N 5 -(1-methyl-1H-pyrazol-4-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 7 ,2-dimethyl-N 5 -(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -((1R,5S,6s)-3-acetyl-3-azabicyclo[3.1.0]hexan-6-yl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)\u2014N 5 -((1R,5S,6s)-3-acetyl-3-azabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R*,3R*)\u2014N 5 -((1R,5S,6r)-3,3-difluorobicyclo[3.1.0]hexan-6-yl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(fluoromethyl)-N 7 -methyl-N 5 -(1-methyl-1H-1,2,4-triazol-3-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(pyridazin-4-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(fluoromethyl)-N 7 -methyl-N 5 -(1-methyl-1H-1,2,3-triazol-4-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(fluoromethyl)-N 7 -methyl-N 5 -(4-methyl-4H-1,2,4-triazol-3-yl)-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(fluoromethyl)-N 5 -((trans)-2-(2-hydroxyethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide (diastereomeric mixture); \n (2R,3R)-2-(fluoromethyl)-N 5 -((trans)-2-(2-hydroxyethyl)cyclopropyl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide (diastereomeric mixture); \n (2S,3R)\u2014N 5 -(3-((S*)-3,3-difluoropiperidin-4-yl)propyl)-N7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -(3-((R*)-3,3-difluoropiperidin-4-yl)propyl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2R,3R)-2-(Fluoromethyl)-N 7 -methyl-3-phenyl-N 5 -(pyrimidin-5-yl)-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-3-(3-(2-methoxyethoxy)phenyl)-N 7 ,2-dimethyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3R)\u2014N 5 -((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-N 7 ,2-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n (2S,3S)-2-(Fluoromethyl)-N 5 -((1R,3R,5S,6r)-3-hydroxybicyclo[3.1.0]hexan-6-yl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; or (2S,3S)-2-(Fluoromethyl)-N 5 -((1R,3S,5S,6r)-3-hydroxybicyclo[3.1.0]hexan-6-yl)-N 7 -methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide; \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 97.0
- Lexical Diversity: 1.125
- Patent Class: 549.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15757199', '15762229', '15766222', '15045679', '14546896']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7474553014647964
- 35 USC 102 Novelty (BERT): 0.5670290257664808
- Combined Prediction Score: 0.7294126738949649
- Mean Citation Score: 375.658508
- Max Citation Score: 444.02606
- Similarity Product: 355.7328912965773

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test