PATENT CLAIM ANALYSIS

Application Number: 16021024
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-11
Patent Classification: ["435", "069500"]

Abstract:
Provided are methods for identifying T-cell receptors that bind to an antigen in primates. In certain embodiments, the methods comprise: sequencing the cDNA prepared from a combined population of T-cells to obtain a plurality of T-cell receptor alpha chain sequences and a plurality of T-cell receptor beta chain sequences; grouping the obtained alpha chain sequences into alpha chain groups based on their CDR3 sequences; grouping the obtained beta chain sequences into beta chain groups based on their CDR3 sequences; pairing the alpha chain groups with the beta chain groups based on the number of alpha chain or beta chain sequences in each group; pairing one alpha chain sequence and one beta chain sequence in each paired alpha chain group and beta chain group; and testing candidate T-cell receptor comprising the paired alpha chain and beta chain sequences for binding to the antigen.

Claim (Index 2):
The method of  claim 1 , wherein the antigen is a human antigen.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 94.0
- Lexical Diversity: 2.47541
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15208850', '13802172', '10287941', '14383602', '15995584']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.556687799913676
- 35 USC 102 Novelty (BERT): 0.6200501826242231
- Combined Prediction Score: 0.5630240381847308
- Mean Citation Score: 339.87637399999994
- Max Citation Score: 538.49335
- Similarity Product: 530.7368924049109

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test