PATENT CLAIM ANALYSIS

Application Number: 16039877
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["514", "219000"]

Abstract:
Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted fused quadracyclic compounds.

Claim (Index 39):
A method of treating or preventing a mitogen-activated protein kinase activated protein kinase-2 (MK2) related disorder, comprising administering to a subject a compound having a structure of Formula I or a pharmaceutically acceptable salt thereof: wherein\n X 1 , X 2 , and X 3  are, independently for each occurrence, CR 5  or N; \n X 5 , X 6 , and X 7  are, independently for each occurrence, CR 7  or N; \n R 1  is, independently for each occurrence, H, halo, \u2014OH, \u2014CN, or optionally substituted alkyl, alkoxy, \u2014O\u2014R 31 , \u2014O\u2014C(O)\u2014NR 31 R 32 , or \u2014C(O)\u2014OR 31 ; \n R 2  is H, halo, \u2014CN, alkyl, or \u2014C(O)\u2014OR 41 ; \n R 3  is H, alkyl, or cycloalkyl; \n R 5  is H, halo, \u2014CN or optionally substituted alkyl, alkoxy, aryl, heteroaryl, O\u2014C(O)\u2014NR 61 R 62 , or \u2014C(O)\u2014OR 61 ; \n R 7  is H, halo, \u2014OH, \u2014CN, or optionally substituted alkyl, alkoxy, \u2014O\u2014C(O)\u2014NR 71 2 , or \u2014C(O)\u2014OR 71 ; \n R 31  and R 32  are, independently for each occurrence, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, aryl, or aralkyl; \n R 41  is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, aryl, or aralkyl; \n R 61  and R 62  are, independently for each occurrence, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, aryl, or aralkyl; \n R 71  is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, aryl, or aralkyl; \n Z is halo or optionally substituted amino, alkylamino, heteroalkylamino, cycloalkylamino, or heterocycloalkylamino; and \n n is an integer from 0-5.

Metadata:
- Claim Count in Document: 110.0
- Percentile: 95.0
- Lexical Diversity: 1.65217
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15397212', '13249166', '14448160', '12598882', '14728562']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7389205387461176
- 35 USC 102 Novelty (BERT): 0.5673858374708717
- Combined Prediction Score: 0.7217670686185931
- Mean Citation Score: 328.424554
- Max Citation Score: 461.9091
- Similarity Product: 338.03122811847925

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test