PATENT CLAIM ANALYSIS

Application Number: 16060404
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["424", "204100"]

Abstract:
A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates

Claim (Index 12):
A method for separating AAVrh10 viral particles from AAVrh10 capsid intermediates, said method comprising:\n (a) mixing a suspension comprising recombinant AAVrh10 viral particles and AAV rh10 capsid intermediates and a Buffer A having a pH of about 10.0; (b) loading the suspension of (a) onto a strong anion exchange resin column; (c) washing the loaded anion exchange resin with Buffer 1% B which comprises a salt having and a pH of about 10.0; (d) applying an increasing salt concentration gradient to the loaded and washed anion exchange resin, wherein the salt gradient is sufficient to elute the rAAVrh10 particles; and\n (e) collecting rAAVrh10 particles which are at least about 90% purified from AAVrh10 intermediates.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 1.26923
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15544498', '13328306', '15081001', '10166347', '10016767']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7374811167212212
- 35 USC 102 Novelty (BERT): 0.5313600659370655
- Combined Prediction Score: 0.7168690116428056
- Mean Citation Score: 331.86248
- Max Citation Score: 367.2632
- Similarity Product: 259.60502491927144

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test