PATENT CLAIM ANALYSIS

Application Number: 15979105
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-05
Patent Classification: ["514", "259300"]

Abstract:
Pharmaceutical compositions comprising a molecular inhibitor of Npr1 are disclosed. Also disclosed are methods of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising a molecular inhibitor of Npr1.

Claim (Index 5):
A method of treating, reducing, or preventing acute and/or chronic pruritus in a mammal comprising administering a pharmaceutical composition comprising (a) a pharmaceutically acceptable carrier and (b) one or more compounds selected from the group consisting of:\n (a) 4-(cyclohexylmethyl)-4,5-dihydrospiro[benzo[e][1,4]diazepine-3,4\u2032-piperidin]-2(1H)-one hydrochloride; (b) 2-(4-chlorophenyl)-1-(1\u2032-(pyrrolidin-3-ylmethyl)-1,5-dihydrospiro[benzo[c]azepine-4,2\u2032-pyrrolidin]-2(3H)-yl)ethan-1-one; (c) N-4(2R,4S,5R)-5-(6-(pentan-3-yl)-2-(pyridin-4-yl)pyrimidin-4-yl)quinuclidin-2-yl)methyl)thiophene-2-sulfonamide; (d) N-(1-(3-methoxy-5-(pyridin-4-yl(benzyl)-4-methylpiperidin-4-yl)acetamide; (e) 3,5-dimethyl-4-(6-(2-phenoxyphenyl)imidazo[1,5-a]pyridin-8-yl)isoxazole; (f) 3-(2-methoxyphenyl)-N-(pyridin-3-ylmethyl)-1H-pyrazolo[3,4-b]pyrazine-5-carboxamide; (g) 3-phenyl-N-(pyridin-3-ylmethyl)-1H-pyrazolo [3,4-b]pyrazine-5-carboxamide; (h) 2-(benzo[d][1,3]dioxo1-5-yl)-1-(3-(2-(benzyloxy)phenyl)-2-methyl-6,7-dihydropyrazolo[1,5-a]pyrimidin-4(5H)-yl)ethan-1-one; (i) 1-(3-(2-(benzyloxy)phenyl)-2-methyl-6,7-dihydropyrazolo[1,5-a]pyrimidin-4(5H)-yl)-2-(pyridin-2-yl)ethan-1-one; (j) 2-(benzo[d][1,3]dioxo1-5-yl)-1-(2-methyl-3-(2-phenoxyphenyl)-6,7-dihydropyrazolo[1,5-a]pyrimidin-4(5H)-yl)ethan-1-one; (k) 1-cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl(methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide; (l) (1-(4-methoxyphenyl)cyclopropyl)(5-methyl-5,6-dihydrospiro[benzo[f]imidazo[1,2-a][1,4]diazepine-4,4\u2032-piperidin]-1\u2032-yl)methanone; (m) N-benzyl-1-(2-cyanobenzyl)-4-oxo-1,5-diazacycloundecane-8-carboxamide; or (n) N-benzyl-N-methyl-8-phenylimidazo[1,2-a]pyrazine-2-carboxamide.

Metadata:
- Claim Count in Document: 33.0
- Percentile: 93.0
- Lexical Diversity: 1.51852
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14774597', '14443602', '15105224', '15463051', '14380078']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6783780057581132
- 35 USC 102 Novelty (BERT): 0.5105629238327167
- Combined Prediction Score: 0.6615964975655736
- Mean Citation Score: 208.8756
- Max Citation Score: 234.87299
- Similarity Product: 154.41992595507386

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test