PATENT CLAIM ANALYSIS

Application Number: 15762897
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "292000"]

Abstract:
The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.

Claim (Index 45):
A method of treating cancer in a subject, comprising administering to the subject a compound of Formula 1: wherein,\n J and K are both hydrogen, or J and K taken together form a bond resulting in a six-membered ring, or J and K taken together represent \u2014CH2- resulting in a seven-membered ring; \n R1 is H, optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkenyl; optionally substituted C3-C8 cycloalkyl; or an optionally substituted C4-C8 cycloalkylalkyl; \n R2 is H, C1-C6 alkoxy such as but not limited to methoxy or ethoxy; trifluoromethyl, halogen, methylcarboxy, ethylcarboxy; optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n Z1 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH 2 ) n \u2014, \u2014C3-C7 cycloalkyl-CH2-, \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-CH 2 NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)NH\u2014, \u2014(CH 2 ) n N(CH 2 CH 2 C 6 H 5 ); or an optionally substituted C6-C12 aryl; \n R3 is H, optionally substituted C1-C9 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C3-C7 cycloalkyl; \u2014(CH 2 ) p \u2014NH(CO)O\u2014(C1-C6 alkyl); \u2014CH 2 O(CH 2 ) p \u2014NH(CO)O\u2014(C1-C6) alkyl; \u2014(CH 2 ) p \u2014NHCO\u2014(CH 2 ) p \u2014NH(CO)O-C1-C6 alkyl); \u2014NH(CO)O-tert-butyl; \u2014O-tert-butyl; or -tert-butyl; \u2014CONH-aryl; \n m=1-5; n=1-8; p=1-9; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n a compound of Formula 2: \n wherein,\n R1 is H, optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkenyl; an optionally substituted unsubstituted C3-C8 cycloalkyl; or optionally substituted C4-C8 cycloalkylalkyl; \n R2 is H, C1-C6 alkoxy such as but not limited to methoxy or ethoxy; trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n Z1 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH 2 ) n \u2014, \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH2) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-CH 2 NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)NH\u2014, \u2014(CH 2 ) n N(CH 2 CH 2 C 6 H 5 )\u2014, optionally substituted C6-C12 aryl; \n R3 is H, optionally substituted C1-C9 alkyl; C2-C6 alkenyl; optionally substituted C6-C12 aryl such as but not limited to phenyl or naphthyl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C3-C7 cycloalkyl; \u2014(CH2) p \u2014NH(CO)O\u2014(C1-C6 alkyl); \u2014CH 2 O(CH 2 ) p \u2014NH(CO)O\u2014(C1-C6) alkyl; \u2014(CH 2 ) p \u2014NHCO\u2014(CH 2 ) p \u2014NH(CO)O-C1-C6 alkyl); \u2014NH(CO)O-tert-butyl; \u2014O-tert-butyl; -tert-butyl; CONH-aryl; \n m=1-5; n=1-8; p=1-9; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH2, \u2014N3, \u2014CN, \u2014NO2, \u2014CHO, \u2014COOH, \u2014CONH2, \u2014C(\u2550NH)NH2, or \u2014SO 3H ; \n a compound of Formula 3: \n wherein,\n R1 is H, optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkenyl; optionally substituted C3-C8 cycloalkyl; or an optionally substituted C4-C8 cycloalkylalkyl; \n R2 is H, C1-C6 alkoxy such as but not limited to methoxy or ethoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n Z1 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH 2 ) n \u2014, \u2014C3-C7 cycloalkly-CH2-, \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-CH 2 NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)NH\u2014, \u2014(CH 2 ) n N(CH 2 CH 2 C 6 H 5 )\u2014, optionally substituted C6-C12 aryl; \n R3 is H, optionally substituted C1-C9 alkyl, C2-C6 alkenyl; optionally substituted C6-C12 aryl, optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; or an optionally substituted C3-C7 cycloalkyl; \u2014(CH 2 ) n \u2014NH(CO)O\u2014(C1-C6 alkyl); \u2014CH 2 O(CH 2 ) p \u2014NH(CO)O\u2014(C1-C6) alkyl; \u2014(CH 2 ) p \u2014NHCO\u2014(CH 2 ) m-NH(CO)O-C1-C6 alkyl); \u2014NH(CO)O-tert-butyl; \u2014O-tert-butyl; or -tert-butyl; CONH-aryl; \n m=1-5; n=1-8; p=1-9; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n a compound of Formula 4: \n wherein,\n R1 is optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkenyl; optionally substituted C3-C8 cycloalkyl; or an optionally substituted C4-C8 cycloalkylalkyl; \n R2 is H, C1-C6 alkoxy such as but not limited to methoxy or ethoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n G1 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH 2 ) n \u2014, \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH2NH(CO)O\u2014, \u2014CH2NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-NH(CO)NH\u2014, \u2014N(CH 2 CH 2 C 6 H 5 )\u2014; \n R4 is H, optionally substituted with halogen, ethylcarboxy, methylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n m=1-5; n=1-8; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n a compound of Formula 5: \n wherein,\n R1 is H, optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkenyl; an optionally substituted unsubstituted C3-C8 cycloalkyl; or optionally substituted C4-C8 cycloalkylalkyl; \n R2 is hydrogen, C1-C6 alkoxy such as but not limited to methoxy or ethoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n G1 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH 2 ) n \u2014, \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH2) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-NH(CO)NH\u2014, \u2014N(CH 2 CH 2 C 6 H5)-, \u2014C3-C7 cycloalkyl-CH 2 \u2014 such as but not limited to -cyclohexyl-CH 2 \u2014; \n Z2 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH 2 ) n \u2014, \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) n NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-NH(CO)NH\u2014, \u2014N(CH 2 CH 2 C 6 H5)-; optionally substituted C6-C12 aryl; \n R5 is H, methyl, C1-C6 alkyl, C1-C3 arylalkyl, 2-phenylethyl; \n R4 is H, optionally substituted C1-C9 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C6-C12 aryl such as but not limited to phenyl or naphthyl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; or an optionally substituted C3-C7 cycloalkyl; \u2014(CH 2 ) p \u2014NH(CO)O\u2014(C1-C6 alkyl); \u2014CH 2 O(CH 2 ) p \u2014NH(CO)O\u2014(C1-C6) alkyl; \u2014(CH 2 ) p \u2014NHCO\u2014(CH 2 ) n \u2014NH(CO)O-C1-C6 alkyl); \u2014NH(CO)O-tert-butyl; \u2014O-tert-butyl; -tert-butyl; \n m=1-5; n=1-8; p=1-9; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n a compound of Formula 6: \n wherein,\n R1 is H, optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkenyl; optionally substituted C3-C8 cycloalkyl; or an optionally substituted C4-C8 cycloalkylalkyl; \n R2 is hydrogen, C1-C6 alkoxy such as but not limited to methoxy or ethoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n G1 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH2) n \u2014, \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-NH(CO)NH\u2014, \u2014N(CH 2 CH 2 C6H 5 )\u2014, \u2014C3-C7 cycloalkyl-CH 2 \u2014 such as but not limited to -cyclohexyl-CH2-; \n Z2 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH2) n \u2014; \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) p NH(CO)O\u2014, \u2014(CH 2 ) n NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-NH(CO)NH\u2014, \u2014N(CH 2 CH 2 C 6 H 5 )\u2014; \n R5 is H, methyl, C1-C6 alkyl, C1-C3 arylalkyl, 2-phenylethyl; \n X is H, C1-C3 alkyl, C1-C3 arylalkyl; \n m=1-5; n=1-8; p=1-9; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n a compound of Formula 7: \n wherein,\n R1 is H, optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted arylalkenyl; an optionally substituted C3-C8 cycloalkyl; or optionally substituted C4-C8 cycloalkylalkyl; \n R2 is hydrogen, C1-C6 alkoxy such as but not limited to methoxy or ethoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n G2 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH 2 ) n \u2014, \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl- such as but not limited to -cyclohexyl-, \u2014N(CH 2 CH 2 C 6 H 5 ); \n Z2 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH 2 ) n \u2014, \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH 2 ) p NH(CO)\u2014, \u2014(CH 2 ) p NH(CO)O\u2014, \u2014(CH 2 ) n NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-NH(CO)NH\u2014, \u2014N(CH 2 CH2C 6 H 5 )\u2014; \n R5 can be H, methyl, C1-C6 alkyl, C1-C3 arylalkyl, 2-phenylethyl; \n X is H, C1-C3 alkyl, C1-C3 arylalkyl; \n m==; n=1-8; p=1-9; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n a compound of Formula 8: \n wherein,\n R1 is H, optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted arylalkenyl; an optionally substituted C3-C8 cycloalkyl; or optionally substituted C4-C8 cycloalkylalkyl; \n R2 is hydrogen, C1-C6 alkoxy such as but not limited to methoxy or ethoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n Z2 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH2) n \u2014; \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-NH(CO)NH\u2014, \u2014N(CH 2 CH 2 C 6 H 5 )\u2014; \n R5 is H, methyl, C1-C6 alkyl, C1-C3 arylalkyl, 2-phenylethyl; \n X is H, C1-C3 alkyl, C1-C3 arylalkyl; \n R6 is H, C1-C3 alkyl; \n m=1-5; n=1-8; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n a compound of Formula 9: \n wherein,\n R1 is H, optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkenyl; optionally substituted C3-C8 cycloalkyl; or an optionally substituted C4-C8 cycloalkylalkyl; \n R2 is hydrogen, C1-C6 alkoxy such as but not limited to methoxy or ethoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n R5 is H, methyl, C1-C6 alkyl, C1-C3 arylalkyl, 2-phenylethyl; \n X can be H, C1-C3 alkyl, C1-C3 arylalkyl; \n Z2 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH 2 ) n \u2014; \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH2NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-NH(CO)NH\u2014, \u2014N(CH 2 CH 2 C 6 H 5 )\u2014; \n m=1-5; n=1-8; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; or \n a compound is of Formula 10: \n wherein,\n R1 is H, optionally substituted C1-C6 alkyl; optionally substituted C2-C6 alkenyl; optionally substituted C1-C6 alkoxy; optionally substituted C6-C12 aryl; optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkyl such as but not limited to benzyl or alpha-methylbenzyl; optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O; optionally substituted C7-C15 arylalkenyl; optionally substituted C3-C8 cycloalkyl; or an optionally substituted C4-C8 cycloalkylalkyl; \n R2 is hydrogen, C1-C6 alkoxy such as but not limited to methoxy or ethoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; \n Z3 is a bond, \u2014NH\u2014, \u2014O\u2014, \u2014S\u2014, \u2014CH(CH 3 )\u2014, \u2014(CH2) n \u2014; \u2014CH\u2550CH\u2014, \u2014CO\u2014, \u2014SO\u2014, \u2014SO 2 \u2014 or \u2014C(\u2550NH)\u2014, \u2014CH 2 NH(CO)\u2014, \u2014CH 2 NH(CO)O\u2014, \u2014CH 2 NH(CO)NH\u2014; \u2014(CH 2 ) n NH(CO)\u2014, \u2014(CH 2 ) n NH(CO)O\u2014, \u2014(CH 2 ) m NH(CO)NH\u2014; \u2014C3-C7 cycloalkyl-NH(CO)\u2014, \u2014C3-C7 cycloalkyl-CH 2 NH(CO)O\u2014, \u2014C3-C7 cycloalkyl-NH(CO)NH\u2014, \u2014N(CH 2 CH 2 C 6 H 5 )\u2014; \n R7 is H, methyl, C1-C6 alkyl, C1-C3 arylalkyl, 2-phenylethyl; \n m=1-5; n=1-8; \n where \u201csubstituted\u201d means substituted with one or more independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, methoxy, ethoxy, C1-C6 alkoxy, C1-C6 alkyl, \u2014OH, \u2014SH, \u2014NH 2 , \u2014N 3 , \u2014CN, \u2014NO 2 , \u2014CHO, \u2014COOH, \u2014CONH 2 , \u2014C(\u2550NH)NH 2 , or \u2014SO 3 H; or \n as set forth in  FIGS. 18-27 .

Metadata:
- Claim Count in Document: 14.0
- Percentile: 90.0
- Lexical Diversity: 1.575
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12432615', '14089655', '13190324', '14452183', '14784957']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7494920396142566
- 35 USC 102 Novelty (BERT): 0.5067799262731377
- Combined Prediction Score: 0.7252208282801447
- Mean Citation Score: 261.19196400000004
- Max Citation Score: 269.17386
- Similarity Product: 189.83435803091527

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test