PATENT CLAIM ANALYSIS

Application Number: 15921442
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "123000"]

Abstract:
Methods of producing peptide beta-lactones and beta-hydroxy acids are disclosed that include contacting a beta-hydroxy-alpha-amino acid, an aryl carrier protein (ObiD), and ATP with a non-ribosomal protein synthetase. A continuous flow reactor is disclosed that includes an elongate conduit with at least one region that includes a first region with a non-ribosomal protein synthetase immobilized to a substrate. The non-ribosomal protein synthetase of the continuous flow reactor is configured to contact a flow of a reaction mixture that includes a beta-hydroxy-alpha-amino acid and an aryl carrier protein. The non-ribosomal protein synthetase is further configured to release a peptide beta-lactone into the flow of the reaction mixture.

Claim (Index 2):
The method of  claim 1 , wherein the peptide beta-lactone is selected from the group consisting of an obafluorin and an obafluorin analog, the obafluorin analog comprising a compound with the structure: wherein n=0, 1, or 2; and\n R=

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 2.07273
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12842549', '12118362', '10925357', '11775216', '10017324']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5328293721962852
- 35 USC 102 Novelty (BERT): 0.5054335140960876
- Combined Prediction Score: 0.5300897863862655
- Mean Citation Score: 208.44705400000004
- Max Citation Score: 260.4539
- Similarity Product: 191.6127081144452

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test