PATENT CLAIM ANALYSIS

Application Number: 16269628
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "158000"]

Abstract:
This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

Claim (Index 9):
A method for slowing progression of calcification of a heart valve, wherein said method comprises administering, as the sole active ingredient for slowing said progression, a sGC agonist to a mammal identified as having heart valve calcification, wherein said sGC agonist slows progression of calcification of a heart valve within said mammal, and wherein the sGC agonist is BAY 58-2667 (4-[((4-Carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid hydrochloride), BAY 41-2272 (3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine), BAY-41-8543 (2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine), or BAY 63-2521 (methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate).

Metadata:
- Claim Count in Document: 34.0
- Percentile: 99.0
- Lexical Diversity: 1.39535
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15702461', '14652903', '14861428', '12908467', '12227872']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7851140870478182
- 35 USC 102 Novelty (BERT): 0.6677308500383916
- Combined Prediction Score: 0.7733757633468755
- Mean Citation Score: 387.797056
- Max Citation Score: 640.1366
- Similarity Product: 590.9504983077169

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test