PATENT CLAIM ANALYSIS

Application Number: 16076479
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["424", "136100"]

Abstract:
The present invention relates to engineered cells, engineered chimaeric antigen ligands (CALs), novel uses of multi-specific binding agents for bridging cells, and methods of therapy. The invention also provides variation-matched engineered cells.

Claim (Index 83):
A method of targeting an immune cell to a target cell, the method comprising\n A. providing a bridging agent, wherein the agent is a multi-specific binding fragment comprising\n i. a first binding moiety; and \n ii. a second binding moiety; \n B. providing an immune cell, wherein the immune cell expresses a transmembrane protein comprising an engineered combination of\n iii. an extracellular part comprising a third binding moiety that is linked to a transmembrane domain; wherein the second and third moieties form a first specific binding pair wherein one moiety specifically binds to the other moiety; and \n iv. an intracellular part comprising a first signaling domain for intracellular signaling when the second and third moieties bind together; \n C. combining the immune cell and bridging agent with the target cell, the target cell comprising a fourth binding moiety, wherein the fourth moiety is extracellular, wherein\n v. the first and fourth moieties form a second specific binding pair, wherein one moiety specifically binds to the other moiety to target the immune cell to the target cell; and \n vi. the second and third moieties bind together thereby triggering intracellular signaling in the immune cell to regulate immune cell activity; and \n wherein the third binding moiety comprises a ligand, and the second binding moiety comprises a ligand binding site that specifically binds to the ligand.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 96.0
- Lexical Diversity: 1.34483
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15866222', '15934770', '15105074', '15637734', '15106783']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7389250972206381
- 35 USC 102 Novelty (BERT): 0.5198330162553563
- Combined Prediction Score: 0.71701588912411
- Mean Citation Score: 319.32395
- Max Citation Score: 322.89294
- Similarity Product: 224.75332231584903

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test