PATENT CLAIM ANALYSIS

Application Number: 15752417
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["250", "458100"]

Abstract:
The present disclosure discloses a total internal reflection fluorescence imaging system and a sequencing device. The total internal reflection fluorescence imaging system includes a first imaging system and a second imaging system. The first imaging system includes N separate laser light paths. The second imaging system determines the changes of the height of the sample by means of the differences of the positions at which the second receiving device acquires the second images, and performs automatic compensation according to the changes of the height of the sample, so as to ensure that the sample is always at a focused position. The embodiment can perform light path adjustment of the N separate laser light paths respectively by means of the second imaging system, so as to realize that the N separate laser light paths have the same penetration depth. Therefore no further light path adjustment is required when switching between different light sources, thus saving the time consuming for light path adjustment.

Claim (Index 1):
A total internal reflection fluorescence imaging system, comprising:\n a first imaging system, wherein the first imaging system comprises N separate laser light paths, an objective lens, and a first receiving device, N is an integer greater than one, each of the laser light path is configured to generate light to enter the objective lens, the light passing through the objective lens illuminates a sample to excite the sample to emit fluorescence, the fluorescence passes through the objective lens and enters the first receiving device to form a first image; and a second imaging system, wherein the second imaging system comprises a light emitting source, the objective lens, and a second receiving device, the light emitting source is configured to emit light to enter the objective lens, the light passing through the objective lens illuminates the sample and is reflected, the reflected light passes through the objective lens and enters the second receiving device to form a second image.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 88.0
- Lexical Diversity: 2.22078
- Patent Class: 250.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13884679', '12473745', '15568770', '15574650', '14962988']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6907495813580541
- 35 USC 102 Novelty (BERT): 0.4896058783156354
- Combined Prediction Score: 0.6706352110538122
- Mean Citation Score: 237.815384
- Max Citation Score: 247.02798
- Similarity Product: 192.46605161669967

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test