PATENT CLAIM ANALYSIS

Application Number: 15914351
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "345000"]

Abstract:
The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R 1 , R 2 , R 3 , R 4 , m and n are as described herein.

Claim (Index 37):
A process for preparing a compound of formula Ib\u2033 wherein ring B is a carbocycle or heterocycle; R 3  is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, alkylsulfinyl, alkylsulfonyl, a carbocycle or a heterocycle wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, alkylsulfinyl, alkylsulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; R 6  in each instance is independently hydroxyl, halogen, amino, carbonyl, nitro, cyano, acyl, alkyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, a carbocycle or a heterocycle; wherein said amino, alkyl, carbonyl, acyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, carbocycle and heterocycle substituent is optionally substituted with amino, halogen, hydroxyl, carbonyl, or a carbocycle or heterocycle that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl; o is 0-3; and m is 0-3; said process comprising\n reacting a compound of formula (a) \n wherein Q is Cl, Br or I; with a compound of formula (b) wherein L is Br, I or OTf; to yield a compound of formula (c); reducing said compound of formula (c) to give a compound of formula (d) and reacting said compound of formula (d) with a compound of formula (e) wherein Q\u2032 is halogen, OH, OR wherein R is an activating group; to yield said compound of formula Ib\u2033.

Metadata:
- Claim Count in Document: 66.0
- Percentile: 90.0
- Lexical Diversity: 1.2619
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14575018', '12960609', '15015586', '11217663', '12093530']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.802791151260903
- 35 USC 102 Novelty (BERT): 0.6065023533223172
- Combined Prediction Score: 0.7831622714670443
- Mean Citation Score: 493.964488
- Max Citation Score: 518.9480599999998
- Similarity Product: 500.0022300428544

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test