PATENT CLAIM ANALYSIS

Application Number: 16150623
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-03
Patent Classification: ["514", "001000"]

Abstract:
This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

Claim (Index 66):
The compound of  claim 26  wherein D is the dimer drug moiety having the formula: wherein R 11  is selected from H, P(O) 3 H 2 , C(O)NR aa R bb , or a bond to Sp; R 22  is selected from H, P(O) 3 H 2 , C(O)NR aa R bb , or a bond to Sp; R aa  and R bb  are independently selected from H and C 1 -C 6 alkyl optionally substituted with one or more F, or R aa  and R bb  form a five or six membered heterocycloalkyl group; T is a tether group selected from C 3 -C 12 alkylene, Y 1 , (C 1 -C 6 alkylene)-Y 1 \u2014(C 1 -C 6  alkylene), (C 1 -C 6 alkylene)-Y 1 \u2014(C 1 -C 6 alkylene)-Y 1 \u2014(C 1 -C 6 alkylene), (C 2 -C 6 alkenylene)-Y 1 \u2014(C 2 -C 6 alkenylene), or (C 2 -C 6 alkynylene)-Y 1 \u2014(C 2 -C 6 alkynylene); where Y 1  is independently selected from O, S, NR 11 , aryl, or heteroaryl; where alkylene, alkenylene, aryl, and heteroaryl are independently and optionally substituted with F, OH, O(C 1 -C 6 alkyl), NH 2 , NHCH 3 , N(CH 3 ) 2 , NHC(O)(C 1 -C 6 alkylene) m , OP(O) 3 H 2 , or C 1 -C 6 alkyl, where alkyl is optionally substituted with one or more F, m is 0 or 1; or alkylene, alkenylene, aryl, and heteroaryl are independently and optionally substituted with a bond to Sp, wherein the bond to Sp may connect through one of the optional substituents; D\u2032 is a drug moiety selected from: where the wavy line indicates the site of attachment to T; X 1  and X 2  are independently selected from O or NR 33 , where R 33  is selected from H, C(O), or C 1 -C 6 alkyl, optionally substituted with one or more F, or X 1  and X 2  are each independently absent; R 44  is H, CO 2 R, C(O), or a bond to Sp, where R is C 1 -C 6 alkyl or benzyl; and R 55  is H or C 1 -C 6 alkyl.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 97.0
- Lexical Diversity: 1.14286
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15182429', '15181825', '14305643', '15182444', '15104388']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7793432868723206
- 35 USC 102 Novelty (BERT): 0.5406892938317585
- Combined Prediction Score: 0.7554778875682644
- Mean Citation Score: 337.9627200000001
- Max Citation Score: 363.85858
- Similarity Product: 251.1660212910461

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test