PATENT CLAIM ANALYSIS

Application Number: 16145345
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["546", "117000"]

Abstract:
The present invention provides compounds of Formula (I): wherein A, X and Y are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

Claim (Index 1):
The compound according to the formula (I) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein: ring A is independently phenyl substituted with 0-1 R 2  and 0-4 R 3 , or (a 5- to 6-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR a , O, and S(O) p , wherein said heterocycle is substituted with 0-1 R 2  and 0-3 R 3 ); X is independently CH or N; Y is independently selected from: a hydrocarbon linker substituted with 0-1 R 1 , or a hydrocarbon-heteroatom linker substituted with 0-1 R 1 ; wherein said hydrocarbon linker has one to six carbon atoms and may be straight or branched; and said hydrocarbon-heteroatom linker has one to four carbon atoms and one group selected from O, S, NH, N(C 1-4  alkyl), CONH, and NHCO; R 1  is independently selected from: CN, OH, \u2014(C 1-4  alkyl substituted with 0-1 R 18 ), C 1-4  haloalkyl, Ph, Bn, COPh, CH(OH)Ph, CO 2 (C 1-4  alkyl), and CONHBn; R 2  is independently selected from: \u2014CH(NH 2 )CF 3 , \u2014(CH 2 ) t OH, \u2014O(CH 2 ) 2-3 N(C 1-4  alkyl) 2 , \u2014(CH 2 ) n R 4 , and \u2014(CH 2 ) n (X 1 ) n (CH 2 ) n R 5 ; X 1  is independently selected from: C(Me) 2 , O, S, CO and SO 2 ; R 3  is, at each occurrence, independently selected from: halogen, CN, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, NO 2 , CONH 2 , and SO 2 (C 1-4  alkyl); alternatively, R 2  and R 3 , together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic or heterocyclic ring comprising carbon atoms and 0-3 heteroatoms selected from N, NR a , O, and S(O) p ; wherein said heterocycle is substituted with 0-2 R 19 ; R 4  is independently selected from: halogen, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  alkylthio, C 1-4  haloalkyl, C 1-4  haloalkoxy, C 1-4  haloalkylthio, CN, CO 2 (C 1-4  alkyl), NO 2 , NR 6 R 7 , CONR 6 R 7 , COR 10 , \u2014CONH(CH 2 ) 1-2 NR 9 R 10 , SO 2 NR 9 R 10 , and S(O) p R 8 ; R 5  is independently selected from: C 3-10  carbocycle substituted with 0-2 R 11 , phenyl substituted with 0-3 R 11  and 0-1 R 12 , and 5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR a , O, and S(O) p ; wherein said heterocycle is substituted with 0-2 R 11  and 0-1 R 13 ; R 6  is, at each occurrence, independently selected from: H, C 1-4  haloalkyl, C 1-6  alkyl substituted with 0-2 R 15 , \u2014(CH 2 ) n \u2014(C 3-6  cycloalkyl substituted with 0-1 R 14 ), \u2014(CH 2 ) n -(phenyl substituted with 0-1 R 16 ), \u2014(CH 2 ) n -(a 5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR a , O, and S(O) p , wherein said heterocycle is substituted with 0-1 R 17 ); R 7  is, at each occurrence, independently selected from: H and C 1-4  alkyl substituted with R 11 ; alternatively, R 6  and R 7 , together with the nitrogen atom to which they are attached, combine to form a 4- to 10-membered heterocyclic ring comprising carbon atoms and 1-4 heteroatoms selected from N, NR a , O, and S(O) p ; wherein said heterocycle is substituted with 0-1 R 17 ; R 8  is, at each occurrence, independently selected from: C 1-4  alkyl, \u2014(CH 2 ) t \u2014C 3-6  cycloalkyl, and \u2014(CH 2 ) t -phenyl; R 9  is, at each occurrence, independently selected from: H and C 1-4  alkyl; R 10  is, at each occurrence, independently selected from: R 8  and H; R 11  is, at each occurrence, independently selected from: OH, halogen, C 1-4  alkoxy, C 1-4  haloalkyl, and C 1-4  haloalkoxy; R 12  is independently selected from: halogen, CN, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, C 1-4  alkylthio, OH, CH 2 OH, CO 2 H, CO 2 (C 1-4  alkyl), NH 2 , CH 2 NH 2 , N(C 1-4  alkyl) 2 , CH 2 N(C 1-4  alkyl) 2 , CONH 2 , CONH(C 1-4  alkyl), CONHCH 2 CH 2 (C 1-4  alkyl) 2 , CON(C 1-4  alkyl) 2 , SO 2 NH 2 , SO 2 NH(C 1-4  alkyl), SO 2 N(C 1-4  alkyl) 2 , CONHPh, NHCOPh, \u2014(CH 2 ) n \u2014(C 3-6  carbocycle substituted with 0-2 R c ), and (a 5- to 6-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR a , O, and S(O) p , wherein said heterocycle is substituted with 0-2 R c ); R 13  is independently selected from: R 12  and \u2550O; R 14  and R 16  are, at each occurrence, independently selected from: halogen, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, OH, CH 2 OH, N(C 1-4  alkyl) 2 , CONH 2 , CONH(C 1-4  alkyl), CON(C 1-4  alkyl) 2 , OCH 2 CONH 2 , NHCO(C 1-4  alkyl), NHCO 2 (C 1-4  alkyl), SO 2 (C 1-4  alkyl), \u2014(CH 2 ) n -phenyl, \u2014O\u2014(CH 2 ) n -phenyl, and pyridylmethyl; R 15  is, at each occurrence, independently selected from: OH, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, N(C 1-4  alkyl) 2 , CONH 2 , CONH(C 1-4  alkyl), and CON(C 1-4  alkyl) 2 ; R 17  is independently selected from: R 14  and \u2550O; R 18  is independently selected from: OH, CN, NH 2 , N(C 1-4  alkyl) 2 , NHBn, imidazolyl and morpholinyl; R 19  is independently selected from: halogen and CO 2 (C 1-4  alkyl); R a  is, at each occurrence, independently selected from: H, C 1-4  alkyl, CO(C 1-4  alkyl), CO 2 (C 1-4  alkyl), SO 2 (C 1-4  alkyl), \u2014(CH 2 ) n \u2014C 3-6  cycloalkyl, \u2014(CH 2 ) n -(phenyl substituted with 0-2 R c ), \u2014CO(\u2014(CH 2 ) n -phenyl), (a 5- to 6-membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR b , O, and S(O) p , wherein said heterocycle is substituted with 0-2 R c ); R b  is, at each occurrence, independently selected from: H and C 1-4  alkyl; R c  is, at each occurrence, independently selected from: OH, CN, C 1-4  alkyl, halogen, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, N(C 1-4  alkyl) 2 , \u2014CH 2 N(C 1-4  alkyl) 2 , CONHCH 2 CH 2 N(C 1-4  alkyl) 2 , pyrrolidinyl, piperazinyl, and n is, at each occurrence, independently selected from: 0, 1 and 2; p is, at each occurrence, independently selected from: 0, 1 and 2; and s is, at each occurrence, independently selected from: 1 and 2; provided that is excluded.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 97.0
- Lexical Diversity: 1.33333
- Patent Class: 546.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15756373', '15756367', '15756378', '16099010', '16067619']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8021755449049873
- 35 USC 102 Novelty (BERT): 0.5934262351671185
- Combined Prediction Score: 0.7813006139312004
- Mean Citation Score: 461.02643599999993
- Max Citation Score: 519.0335
- Similarity Product: 451.83098920151593

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test