PATENT CLAIM ANALYSIS

Application Number: 15890374
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["424", "001110"]

Abstract:
The present disclosure provides methods of treating a biological tissue using a proton beam. A method includes the steps of: irradiating a proton beam to a biological tissue containing a reactant. The reactant includes a composite. The composite reacts with at least one proton from the proton beam and releases at least one α particle or γ rays. The α particle or γ rays reacts with the biological tissue. Another method includes the steps of: providing a reactant, the reactant comprising a composite; introducing the reactant into a biological tissue, the reactant being distributed in the biological tissue; and irradiating the biological tissue with the proton beam. The composite reacts with at least one proton from the proton beam to release at least one α particle or γ rays, and the α particle or the γ rays reacts with the biological tissue.

Claim (Index 8):
The method of treating a biological tissue using a proton beam according to  claim 7 , wherein the composite is selected from a group consisting of (L)-4-dihydroxy-borylphenylalanine (BPA), sodium mercaptoun decahydro-closo-dodecaborate (BSH), carbohydrate derivatives of BSH, sodium salt of closo-B 10 H 102 -(GB-10), \u03b2-5-o-carboranyl-2V-deoxyuridine (D-CDU), 3-(dihydroxypropyl-carboranyl-pentyl) thymidine derivative (N5-2OH), boron-containing porphyrins (H2DCP), dequalinium derivatives (DEQ-B), derivatives of trimethoxyindoles, aziridines, derivatives of acridines, phenanthridines, carboranyl polyamines, Pt(II)-amine complexes, dibenzimidazoles, tribenzimidazoles, glucose molecules, mannose molecules, ribose molecules, gulose molecules, fucose molecules, galactose molecules, maltose molecules, lactose molecules, phosphates, phosphonates, phenylureas, thioureas, nitroimidazoles , amines, benzamides, isocyanates, nicotinamides, or azulenes.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 88.0
- Lexical Diversity: 3.18367
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14488293', '13663212', '13658843', '13311025', '11885707']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6897827399589562
- 35 USC 102 Novelty (BERT): 0.5444753073778614
- Combined Prediction Score: 0.6752519967008468
- Mean Citation Score: 167.5734188
- Max Citation Score: 390.17535
- Similarity Product: 366.37772756983634

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test