PATENT CLAIM ANALYSIS

Application Number: 16067643
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["424", "450000"]

Abstract:
Described herein is a method for loading a hydrophilic compound into liposomes after addition of an alkylester group to form an esterified compound. After loading, the alkylester is hydrolyzed to reform the hydrophilic compound inside the liposomes. Also described is a method for loading drugs under a glucuronide methylester form into liposomes. The glucuronide methylester form of the drug is saponified to a glucuronide form of the drug inside the liposomes for better drug retention. The glucuronide residue conjugated to drugs can be removed inside cells to regenerate the parental drug upon cell uptake, liposomal degradation and enzyme hydrolysis. In case of cancer, this method can be used to safely deliver drugs to tumors.

Claim (Index 39):
A method for loading a glucuronide alkylester into liposomes comprising:\n (a) preparing a liposome suspension with an external pH lower than 7 and an internal pH sufficiently high to convert the glucuronide alkylester to a glucuronide, (b) preparing the glucuronide alkylester by conjugating an alkylester group to the glucuronide, and (c) adding the glucuronide alkylester to the liposome suspension, wherein the glucuronide alkylester is loaded into the liposomes;\n wherein the glucuronide alkylester inside the liposomes is saponified to generate a glucuronide.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 95.0
- Lexical Diversity: 1.98387
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15216416', '11601451', '15129317', '11576595', '14632422']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7280242653122864
- 35 USC 102 Novelty (BERT): 0.5026016323613247
- Combined Prediction Score: 0.7054820020171902
- Mean Citation Score: 252.217818
- Max Citation Score: 256.7327
- Similarity Product: 179.5929768520892

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test