PATENT CLAIM ANALYSIS

Application Number: 15773553
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2019-03
Patent Classification: ["544", "287000"]

Abstract:
The applicant provides a compound for enhancing the space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 and anti-hypertension applications thereof. By finding the structural domains of the interacting sites of the endothelial cell ion channel complex TRPV4-KCa2.3, a compound with specificity which can act at the two interacting sites is prepared in the present invention. It is found that the compound can enhance the space coupling degree of the TRPV4-KCa2.3 complex and has great significance for the research and development of anti-hypertension drugs.

Claim (Index 2):
A preparation method of a compound for enhancing a space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 according to  claim 1  comprising\n providing propane diamine with t-butyloxycarboryl to protect a single amino first: \n an exposed amino reacting with diphenylacetyl chloride to generate an amide: removing a t-butyloxycarbonyl protection from the amide under an acidic condition: a compound obtained after removing the t-butyloxycarboryl protection performing an amino-ester exchange with 4-quinazolone-2-carboxylic acid ethyl ester to obtain a target compound:

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.69811
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12996069', '15505898', '15018595', '13703765', '14240798']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6338633094946817
- 35 USC 102 Novelty (BERT): 0.4888947147423315
- Combined Prediction Score: 0.6193664500194468
- Mean Citation Score: 152.962188
- Max Citation Score: 165.9608
- Similarity Product: 111.64304487018585

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test