PATENT CLAIM ANALYSIS

Application Number: 15752854
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["514", "083000"]

Abstract:
Provided herein are optically active compounds of the formulae (ii); and (III) and pharmaceutical compositions thereof. Also provided herein are processes of making these compounds and resolving the racemic mixture or the enrichment of same with in one of its enantiomers to provide (R)- and (S)-1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-nitrophenyl)-1-ethyl-N,N′-bis(ethylene)phosphoramidate, and methods of treating cancer comprising administering such compounds.

Claim (Index 15):
A process for the resolution into one of the enantiomers of the racemate of the compound of  claim 1  or for the enrichment of a mixture with any enantiomeric excess of said compound of formula (I), comprising the following steps: a) subjecting the compound of formula (I): to an optical resolution process wherein a racemic enantiomerically enriched mixture of 1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-nitrophenyl)-1-ethyl-N,N\u2032-bis(ethylene)phosphoramidate is separated into its two enantiomers (S)-1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-nitrophenyl)-1-ethyl-N,N\u2032-bis(ethylene)phosphoramidate and (R)-1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-nitrophenyl)-1-ethyl-N,N\u2032-bis(ethylene)phosphoramidate by chiral chromatography comprising a stationary phase and a mobile phase, wherein the stationary phase comprises a silica gel impregnated with a functionalized polysaccharide, and wherein the mobile phase comprises an alcohol and another solvent.

Metadata:
- Claim Count in Document: 29.0
- Percentile: 88.0
- Lexical Diversity: 1.51786
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15557053', '15877103', '14423359', '15339041', '15553088']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6978305709749059
- 35 USC 102 Novelty (BERT): 0.5184986198881614
- Combined Prediction Score: 0.6798973758662314
- Mean Citation Score: 185.671668
- Max Citation Score: 196.10022
- Similarity Product: 103.77019690018416

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test