PATENT CLAIM ANALYSIS

Application Number: 15881581
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["435", "005000"]

Abstract:
Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions.

Claim (Index 80):
A compound of formula (I): or a salt thereof, wherein F atom at the C3-position is axial or equatorial; R 1  is H or optionally substituted C 1-6  alkyl; R 2  is OR 2O , N 3 , N(R 2N ) 2 , or guanidine; each instance of R 2O  is independently hydrogen, optionally substituted C 1-6  alkyl, optionally substituted acyl, or an oxygen protecting group; each instance of R 2N  is independently hydrogen, optionally substituted C 1-6  alkyl, optionally substituted acyl, or a nitrogen protecting group; each instance of R 3a  and R 3b  is independently hydrogen, \u2014C(\u2550O)\u2014R 3r , or an oxygen protecting group; each instance of R 3r  is optionally substituted C 1-6  alkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycle, optionally substituted alkylaryl, optionally substituted alkylheteroaryl, or optionally substituted alkylheterocycle; X is selected from the group consisting of \u2014O\u2014, \u2014O(C\u2550O)\u2014, \u2014NH\u2014, \u2014NH(C\u2550O)\u2014, \u2014(C\u2550O)NH\u2014, \u2014O(C\u2550O)NH\u2014, \u2014O(C\u2550S)NH\u2014, \u2014NH(C\u2550O)NH\u2014, and \u2014NH(C\u2550S)NH\u2014; R 4  is H, optionally substituted C 1-6  alkyl, or -L-Z; Y is optionally substituted C 1-6  alkyl or -L-Z; each instance of L is independently selected from the group consisting of \u2014(CH 2 ) n \u2014, \u2014(CH 2 ) n C\u2550O\u2014, \u2014(CH 2 ) n NH\u2014, \u2014(C\u2550O)(CH 2 ) n \u2014, \u2014(CH 2 ) n NH(C\u2550O)\u2014, \u2014(C\u2550O)(CH 2 ) n NH(C\u2550O)\u2014, \u2014(CH 2 ) n SCH 2 (C\u2550O)\u2014, and \u2014(CH 2 CH 2 O) n \u2014; each instance of n is an integer from 1 to 8, inclusive; each instance of Z is a functional group for further ligation; and provided that the compound is not of the formula

Metadata:
- Claim Count in Document: 50.0
- Percentile: 86.0
- Lexical Diversity: 1.19565
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14422310', '13662002', '15721393', '15104132', '15847430']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6580382243708538
- 35 USC 102 Novelty (BERT): 0.6125725670387349
- Combined Prediction Score: 0.6534916586376419
- Mean Citation Score: 408.304482
- Max Citation Score: 581.6555
- Similarity Product: 459.23459351089593

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test