PATENT CLAIM ANALYSIS

Application Number: 16274123
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "001100"]

Abstract:
Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

Claim (Index 68):
The method of  claim 66  or  claim 67 , wherein contacting a macrophage with an rcHC-HA/PTX3 or isolated nHC-HA/PTX3 complex:\n (i) reduces the level of IL-12p40 expressed by the macrophage: \n (ii) reduces the level of IL-12p70 expressed by the macrophage; \n (iii) reduces the level of IL-23 expressed by the macrophage; or \n (iv) increases the level of IL-10 expressed by the macrophage. \n (v) induces apoptosis of LPS-stimulated neutrophils; \n (vi) promotes phagocytosis of apoptotic neutrophils; or \n any combination of (i)-(vi) thereof.

Metadata:
- Claim Count in Document: 87.0
- Percentile: 99.0
- Lexical Diversity: 1.63158
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14414047', '15214706', '15160487', '13262725', '13782968']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8336787338308627
- 35 USC 102 Novelty (BERT): 0.630477366869546
- Combined Prediction Score: 0.813358597134731
- Mean Citation Score: 614.755842
- Max Citation Score: 879.9582
- Similarity Product: 517.4079208881857

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test