PATENT CLAIM ANALYSIS

Application Number: 15768470
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["525", "329900"]

Abstract:
Disclosed are the cation polymers capable of removing their positive charges in oxidative conditions, preparation methods, and applications as gene delivery carriers. The oxidation-responsive unit is the p-(boronic acid or ester)benzylammonium, which upon oxidation eliminates p-hydroxymethlphenol and thus converts in a tertiary amine. Compared with the prior art, different from a common quaternary amination carrier, the synthesized charge reversal type gene delivery carrier for oxidative response of the present invention has a large quantity of positive charges and can well coat a DNA, but the positive charges can be removed under the condition of intracellular oxidation when the charge reversal type gene delivery carrier enters a cell, a charge reverse is triggered, the positive charges turn to negative charges, and the DNA is quickly released for transfection. The carrier is efficient, low in toxicity, and good in application prospect.

Claim (Index 10):
The cationic polymer of  claim 1 , wherein the polymer is used for the delivery of taxol.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 91.0
- Lexical Diversity: 1.68085
- Patent Class: 525.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14547051', '15527285', '14293733', '14988538', '14543091']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7568729121652987
- 35 USC 102 Novelty (BERT): 0.5053766691817159
- Combined Prediction Score: 0.7317232878669405
- Mean Citation Score: 262.45788400000004
- Max Citation Score: 275.3442
- Similarity Product: 174.92096239099502

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test