PATENT CLAIM ANALYSIS

Application Number: 15755893
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2019-01
Patent Classification: ["514", "418000"]

Abstract:
The invention relates to antibacterial compounds of formula I wherein X represents sulphur or CH═CH; R 1  represents H, PO 3 H 2 , SO 3 H, phosphonooxymethyl or the group —CO—R 2  wherein R 2  is as defined in the claims M is one of the groups M A  and M B  represented below   wherein A represents a bond or C≡C and R 1A , R 2A , R 3A  and R 1B  are as defined in the claims; and to salts thereof.

Claim (Index 19):
A compound according to  claim 1 , which is selected from the group consisting of:\n (2R)\u2014N-hydroxy-4-(2-((4-(1-hydroxy-2-methylpropan-2-yl)phenyl)ethynyl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(2-((1-(hydroxymethyl)cyclopropyl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(2-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(2-(2-fluoro-4-methoxyphenyl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(2-((1-aminocyclopropyl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(2-(((1R,2R)-2-fluoro-2-(hydroxymethyl)cyclopropyl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-4-(2-((1-(methylamino)cyclopropyl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-(methylsulfonyl)butanamide; (3R)-5-(5-(4-(hydroxyamino)-3-methyl-3-(methylsulfonyl)-4-oxobutyl)-6-oxo-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)penta-2,4-diyn-1-yl 3-hydroxyazetidine-1-carboxylate; (2R)\u2014N-hydroxy-2-methyl-4-(5-((1-(methylamino)cyclopropyl)buta-1,3-diyn-1-yl)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-4-(5-((1-methylazetidin-3-yl)buta-1,3-diyn-1-yl)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)butanamide; (3R)-5-(2-(4-(hydroxyamino)-3-methyl-3-(methylsulfonyl)-4-oxobutyl)-1-oxoisoindolin-5-yl)penta-2,4-diyn-1-yl 3-hydroxyazetidine-1-carboxylate; (2R)-4-(5-(2-fluoro-4-methoxyphenyl)-1-oxoisoindolin-2-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-4-(2-((1-methylazetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(5-((1-(hydroxymethyl)cyclopropyl)buta-1,3-diyn-1-yl)-1-oxoisoindolin-2-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(5-((1-aminocyclopropyl)buta-1,3-diyn-1-yl)-1-oxoisoindolin-2-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(2-((4-((3-fluoroazetidin-1-yl)methyl)phenyl)ethynyl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(2-((1-(oxetan-3-yl)azetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)butanamide; ((1R,2R)-1-fluoro-2-((5-((3R)-4-(hydroxyamino)-3-methyl-3-(methylsulfonyl)-4-oxobutyl)-6-oxo-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)buta-1,3-diyn-1-yl)cyclopropyl)methyl dihydrogen phosphate; (2R)\u2014N-hydroxy-4-(2-((1-(2-hydroxyethyl)azetidin-3-yl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; (2R)-4-(5-(((1R,2R)-2-fluoro-2-(hydroxymethyl)cyclopropyl)buta-1,3-diyn-1-yl)-1-oxoisoindolin-2-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide; (2R)\u2014N-hydroxy-4-(2-(((1S,2S)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-thieno[2,3-c]pyrrol-5-yl)-2-methyl-2-(methylsulfonyl)butanamide; ((1S,2S)-2-((5-((3R)-4-(hydroxyamino)-3-methyl-3-(m ethylsulfonyl)-4-oxobutyl)-6-oxo-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)buta-1,3-diyn-1-yl)cyclopropyl)methyl dimethylglycinate; and (2R)-4-(2-(((1S,3R,4S)-3,4-dihydroxycyclopentyl)buta-1,3-diyn-1-yl)-6-oxo-4,6-dihydro-5H-th ieno[2,3-c]pyrrol-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide;\n or a salt of such compound.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.71154
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15756366', '15123184', '15021649', '15311758', '15106790']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8427238416287353
- 35 USC 102 Novelty (BERT): 0.6104060145018753
- Combined Prediction Score: 0.8194920589160493
- Mean Citation Score: 514.21681
- Max Citation Score: 555.8367
- Similarity Product: 485.4336343629956

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test