PATENT CLAIM ANALYSIS

Application Number: 15989985
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["514", "015200"]

Abstract:
The invention provides methods and materials for making and using variant serum albumin amino acid sequences which exhibit improved properties compared to wild type serum albumin sequences. The invention further provides methods and materials for making and using fusion proteins in which the variant serum albumin amino acid sequences are fused to a therapeutic or diagnostic agent, such as a therapeutic protein, or a functional fragment or variant thereof that maintains activity, and exhibits improved properties.

Claim (Index 2):
A method of making a variant serum albumin polypeptide (VSA) having an altered binding affinity to FcRn as compared with the binding affinity of a wild type serum albumin (HSA) to FcRn comprising:\n providing a nucleic acid encoding a variant serum albumin polypeptide (VSA) comprising a sequence that is at least 90% identical but less than 100% identical to amino acid residues 380 to 585 of SEQ ID NO: 2; introducing the nucleic acid encoding the VSA in a suitable host cell; culturing the host cell under conditions that allow expression of the polypeptide; and isolating the polypeptide from the host cell or from the host cell growth medium, wherein the VSA binds to FcRn with a higher affinity as compared to the binding affinity of HSA to FcRn.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 93.0
- Lexical Diversity: 1.7234
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13985227', '13578688', '14181339', '15915977', '15753947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7236748613373766
- 35 USC 102 Novelty (BERT): 0.5412854459873222
- Combined Prediction Score: 0.7054359198023711
- Mean Citation Score: 294.638252
- Max Citation Score: 307.64963
- Similarity Product: 235.27157162017704

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test