PATENT CLAIM ANALYSIS

Application Number: 15744922
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-09
Patent Classification: ["514", "210160"]

Abstract:
The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.

Claim (Index 1):
A compound selected from the group consisting of:\n (i) a compound of Formula I): wherein: X is C, N, or CR 8 ; R 1  is a C 1 -C 3  alkyl or cyclopropyl, or R 1  forms a link to X or R 2 ; R 2  is H, SH or alkyl; R 3  is H or halo; R 8  is H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy or halo; A is absent or a linker; B is absent or a linker; and R 4  is a 5-membered aryl or heteroaryl, optionally substituted with 1 or 2 substituents; or R 4  is a 6-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R 4  is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R 4  is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents, or R 4  is where p is 0-10; M is CH, NH, or S; Y is NH, CH, O or S; L is a linker or Z; and Z is NH 2 , OH, SH, alkyl, \u2014COOH, or CONH 2 ,\n (ii) a compound of Formula II): \n wherein: X is O, S, or N; R 1  is H, C 1 -C 6 alkyl, \u2014COCHY 2 , \u2014COCH 2 Y, haloalkyl, CH 2 CN, amino, OCH 3 , COOCH 3 , SO 2 CH 3 , COCH 2 OH, or \u2014[NHC(R 7 )] n -M; R 2  and R 3  are independently H or halo; R 4  is a 5-membered aryl or heteroaryl, optionally substituted with 1 or 2 substituents; or R 4  is a 6-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R 4  is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R 4  is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R 4 , is where p is 0-10; M is CH, NH, or S; Y is NH, CH, O or S; L is a linker or Z; and Z is NH 2 , OH, SH, alkyl, \u2014COOH, or CONH 2 ; or R 4  is a carbohydrate,\n a compound of Formula III): \n wherein: (a) n is 1;\n X and Y are oxygen atom; \n W is carbon atom; \n Z is absent; \n R 1  is hydrogen atom, hydroxyl, methoxy, amino, \u2014NH\u2014(CH 2 ) p \u2014R, where p is 0, 1, 2, 3, 4 or 5; R is hydrogen atom, amine, guanidine, piperazine, morpholine, NHCOCH 3 , NHSO 2 CH 3 , NHSO 2 \u2014C 6 H 5  or \u2014Li\u2014B\u2014R 7 ; \n L 1  is \u2014(CH 2 ) q \u2014, \u2014(CH 2 ) q \u2014CH\u2550CH\u2014(CH 2 ) q \u2014, \u2014(CH 2 ) q \u2014O\u2014(CH 2 ) q \u2014, \u2014(CH 2 ) q \u2014NH\u2014(CH 2 ) q \u2014, where q is 0, 1, 2 or 3; \n A and B are independently a cyclyl, heterocyclyl, aryl or heteroaryl, where the cyclyl, heterocyclyl, aryl or heteroaryl can be optionally substituted with 1, 2 or 3 substituents; \n R 7  is hydrogen atom, hydroxyl, halo, nitro, carboxylic acid, methyl ester of carboxylic acid, OMe, nitrile, C(NH)\u2014NH 2 , amino, \u2014NHCOCH 3 , NHSO 2 CH 3 , NHSO 2 -benzene, where the benzene can be optionally and independently substituted at ortho, meta or para position; \n R 2  is -L 1 -A-R 7 ; \n R 3  is H; \n R 4  and R 5  independently are hydrogen, halogen, hydroxyl, or \u2014O\u2014(CH 2 ) t \u2014R 8 , where R 8  is C 1 -C 6 alkyl, amino, di(C 1 -C 6 alkyl)amino, aminocyclopropane, aminocyclopentane, piperazino, or morpholine, and t is 0-10; or \n (b) n is 1;\n X and W are carbon atom, or X is carbon atom and W is nitrogen atom; \n Y is \u2014NH(CH 2 ) q \u2014R 6  or (CH 2 ) q \u2014R 6 , where q=0 to 10; \n R 6  is \u2014COOH, amine, guanidine, piperazine, morpholine; \n Z is hydrogen, methyl, NHR, COCH 3 , SO 2 CH 3 , or \u2014NH\u2014(CH 2 ) l \u2014COOH, where l is 0-10; \n R 1  and R 3  independently hydrogen atom, hydroxyl, methoxy, amino, or -L 1 -A-R 6  \n R is CH 3 , \u2014(CH 2 ) p \u2014CH 3 , where p=0 to 10; \n is \u2014(CH 2 ) n \u2014, \u2014(CH 2 ) t \u2014CH\u2550CH\u2014(CH 2 ) t \u2014, \u2014(CH 2 ) t \u2014O\u2014(CH 2 ) t \u2014, \u2014(CH 2 ) t \u2014NH\u2014(CH 2 ) t \u2014 where t is 0, 1, 2, or 3; \n A is cyclyl, heterocyclyl, aryl or heteroaryl, where the cyclyl, heterocyclyl, aryl or heteroaryl can be optionally substituted with 1, 2 or 3 substituents; \n R 6  is hydrogen atom, hydroxyl, halo, nitro, carboxylic acid, methyl ester of carboxylic acid, OMe, nitrile, C(NH)\u2014NH 2> amino, \u2014NHCOCH 3> NHSO 2 CH 3  NHSO 2 -benzene, where the benzene can be optionally and independently substituted at ortho, meta or para position; \n R 2  is hydrogen atom; \n R 4  and R 5  are independently hydrogen, halogen, hydroxyl, or \u2014O(CH 2 ) x \u2014R 8 , where R 8  is C 1 -C 6 alkyl, amino, di(N(CH 3 ) 2 , N(C 2 H 5 ) 2 , N(i-Pr) 2 , aminocyclopropane, aminocyclopentane, piperazino or morpholine, and x is 0-10, or \n n is 2;\n X and W are carbon atom; \n Y is \u2014NH(CH 2 ) q \u2014R 6  or (CH 2 ) q \u2014R 6 , where q=0 to 10; \n R 6  is \u2014COOH, amine, guanidine, piperazine, morpholine; \n Z is hydrogen, methyl, NHR, COCH 3 , SO 2 CH 3 , or \u2014NH\u2014(CH 2 ) l \u2014COOH, where l is 0-10; \n R 1  and R 3  independently hydrogen atom, hydroxyl, methoxy, amino, or -L 1 -A-R 6  \n R is CH 3 , \u2014(CH 2 ) p \u2014CH 3 , where p=0 to 10; \n L 1  is \u2014(CH 2 ) n \u2014, \u2014(CH 2 ) t \u2014CH\u2550CH\u2014(CH 2 ) t \u2014, \u2014(CH 2 ) t \u2014O\u2014(CH 2 ) t \u2014, \u2014(CH 2 ) t \u2014NH\u2014(CH 2 ) t \u2014 where t is 0, 1, 2, or 3; \n A is cyclyl, heterocyclyl, aryl or heteroaryl, where the cyclyl, heterocyclyl, aryl or heteroaryl can be optionally substituted with 1, 2 or 3 substituents; \n R 6  is hydrogen atom, hydroxyl, halo, nitro, carboxylic acid, methyl ester of carboxylic acid, OMe, nitrile, C(NH)\u2014NH 2 , amino, \u2014NHCOCH 3 , \n NHSO 2 CH 3  NHSO 2 -benzene, where the benzene can be optionally and independently substituted at ortho, meta or para position; \n R 2  is hydrogen atom; \n R 4  and R 5  are independently hydrogen, halogen, hydroxyl, or \u2014O(CH 2 ) x \u2014R 8  where R 8  is Ci-C 6 alkyl, amino, di(N(CH 3 ) 2 , N(C 2 H 5 ) 2 , N(7-Pr) 2 , aminocyclopropane, aminocyclopentane, piperazino or morpholine, and x is 0-10, and \n a compound of Formula IV) wherein: B is absent or a linker; and R 1  is a 5-membered aryl or heteroaryl, optionally substituted with 1 or 2 substituents; or R 1  is a 6-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents; or R 1  is a fused ring 9-10-membered aryl or heteroaryl, optionally substituted with 1, 2 or 3 substituents, a compound of Formula (V): wherein: X and Z are independently C or N; Y is C, N or O; R 1  is H or -L A; R 2  and R 3  are independently O or S; R 4  is hydrogen, oxygen, sulphur, hydroxyl, methoxy or -L 2 -B; R 5 , R 6 , R 7  and R 8  are independently, hydrogen, hydroxyl, fluoro, chloro, bromo, cycloalkyl, heterocyclyl, aryl, heteroaryl, hydroxyl, amino substituted hexose, or guanidine; L 1  is absent, a bond or a linker; L 2  is absent, a bond or a linker; A and B are independently a cyclyl, heterocyclyl, aryl or heteroaryl, where cyclyl, heterocyclyl, aryl and heteroaryl can be optionally substituted with 1, 2 or 3 substituents, a compound of Formula (VI): wherein: X and Z are independently C or N; Y is CH 2 , NH or O; R 1  can be H, OH or -L 1 -A; R 3  is hydrogen, OH, oxygen, sulphur, hydroxyl, methoxy or -L 2 -B; R 4  is O or S; R 5 , R 6 , R 7  and R 8  are independently hydrogen, hydroxyl, halo, cycloalkyl, heterocyclyl, aryl, heteroaryl, hydroxyl, amino substituted hexose, or guanidine; L 1  is absent, a bond or a linker; L 2  is absent, a bond or a linker; and A and B are independently cyclyl, heterocyclyl, aryl or heteroaryl, where cyclyl, heterocyclyl, aryl and heteroaryl can be optionally substituted with 1, 2 or 3 substituents, and a compound of Formula VII): wherein: X is CHR 12 , C\u2550R 13 , NH, S or O; Y is O or S; R 1  can be H, alkylamino, \u2014OH, \u2014NH(CH 2 ) 2 NH 2  or -L 1 -A; R 2  and R 3  are independently hydrogen, hydroxyl of or -L 2 -B; R 4  and R 5  are independently H, halo, hydroxyl, or \u2014(CH 2 ) n \u2014O\u2014(CH 2 ) n -D-R 8 , \u2014(CH 2 ) n \u2014NH\u2014(CH 2 ) n -D-R 8 ; R 8  is H, hydroxyl, halo, trifluoromethyl, alkyl, alkoxy, acyloxy, amino, dialkylamino, \u2014CO 2 H, nitro, nitrile or \u2014NHSO 2 CH 3 ; R 12  is H, amino, hydroxyl, or thiol; R 13  is O, S or NH; L 1  is absent, a bond or a linker; L 2  is absent, a bond or a linker; A, B and D are independently cyclyl, heterocyclyl, aryl or heteroaryl, where cyclyl, heterocyclyl, aryl and heteroaryl can be optionally substituted with 1, 2 or 3 substituents; and n is 0, 1, 2 or 3.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 86.0
- Lexical Diversity: 1.19231
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15326262', '15401791', '15847628', '09815310', '13177981']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7784759794429477
- 35 USC 102 Novelty (BERT): 0.5290985095453864
- Combined Prediction Score: 0.7535382324531915
- Mean Citation Score: 315.793146
- Max Citation Score: 320.35663
- Similarity Product: 203.21857252635647

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test