PATENT CLAIM ANALYSIS

Application Number: 15906268
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "233200"]

Abstract:
The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.

Claim (Index 20):
The pharmaceutical composition according to  claim 19  comprising a compound selected from formulae Id-1, Id-2, Id-3 and Id-4 or a pharmaceutically acceptable salt or solvate thereof and at least one pharmaceutically acceptable carrier, diluent, excipient and/or adjuvant, wherein a depicts the bond linking R 1  to the piperazine moiety; and Ar 2 , R 1 , X 1  and X 2  are as defined in claim  2 ; and R 4 , R 4\u2032 , R 5 , R 5\u2032  and R 6  are independently selected from H, halo, cyano, alkyl, haloalkyl, C3-C6 cycloalkyl, heteroalkyl, heterocyclyl, aryl, heteroaryl, hydroxyl, alkoxy, haloalkoxy, alkoxyalkoxy, alkylamino, carboxy, alkoxycarbonyl, alkylcarbonyloxy, alkylcarbonylamino, haloalkylcarbonylamino, carbamoyl, alkylcarbamoyl, carbamoylamino, alkylcarbamoylamino, alkylsulfonyl, haloalkylsulfonyl, sulfamoyl, alkylsulfamoyl, alkylsulfonylamino, haloalkylsulfonylamino, or R 5  together with R 4  or R 6 , or R 5\u2032  together with R 4\u2032  or R 6  forms an alkylenedioxy group or a haloalkylenedioxy group, or R 5  together with R 4  or R 6 , or R 5\u2032  together with R 4\u2032  or R 6  forms an aryl moiety fused to the phenyl group to which they are attached, each of said substituents being optionally substituted by one or more further substituent(s) selected from halo, cyano, alkyl, haloalkyl, cyclopropyl; and R 7  is H or methyl; and R 7\u2032  is H or methyl; and Ar 4  is a cycloalkyl or an aryl group, each of said cycloalkyl or aryl groups being optionally substituted by one or more group(s) selected from halo, alkyl, haloalkyl, cyclopropyl, haloalkoxy, aryloxy; and M 1  is N or C\u2014R 4\u2033  wherein R 4\u2033  is selected from H, halo, cyano, alkyl, haloalkyl, C3-C6 cycloalkyl, heteroalkyl, heterocyclyl, aryl, heteroaryl, hydroxyl, alkoxy, haloalkoxy, alkoxyalkoxy, alkylamino, carboxy, alkoxycarbonyl, alkylcarbonyloxy, alkylcarbonylamino, haloalkylcarbonylamino, carbamoyl, alkylcarbamoyl, carbamoylamino, alkylcarbamoylamino, alkylsulfonyl, haloalkylsulfonyl, sulfamoyl, alkylsulfamoyl, alkylsulfonylamino, haloalkylsulfonylamino, each of said substituents being optionally substituted by one or more further substituent(s) selected from halo, cyano, alkyl, haloalkyl, cyclopropyl; and M 2  is N or M 2  is C\u2014R 5\u2033  under the condition that M 1  is N, wherein R 5\u2033  is selected from H, halo, cyano, alkyl, haloalkyl, C3-C6 cycloalkyl, heteroalkyl, heterocyclyl, aryl, heteroaryl, hydroxyl, alkoxy, haloalkoxy, alkoxyalkoxy, alkylamino, carboxy, alkoxycarbonyl, alkylcarbonyloxy, alkylcarbonylamino, haloalkylcarbonylamino, carbamoyl, alkylcarbamoyl, carbamoylamino, alkylcarbamoylamino, alkylsulfonyl, haloalkylsulfonyl, sulfamoyl, alkylsulfamoyl, alkylsulfonylamino, haloalkylsulfonylamino, or R 5\u2033  together with R 6  forms an alkylenedioxy group or a haloalkylenedioxy group, or an aryl moiety fused to the pyridinyl group to which they are attached, each of said substituents being optionally substituted by one or more further substituent(s) selected from halo, cyano, alkyl, haloalkyl, cyclopropyl; and wherein, in formula Id-1 when: R 1  is H, and R 4 , R 4\u2032 , R 5 , R 5\u2032  and R 6  are independently selected from H, halo, cyano, C1-C3 alkyl, C1 haloalkyl, and Ar 2  is a 5- to 6-membered aryl or heteroaryl group optionally substituted by one or more group(s) selected from halo, C1-C3 alkyl, hydroxyl, alkoxy, or fused to an aryl group optionally substituted by one or more further halo, C1-C3 alkyl, hydroxyl, methoxy then, R 4 , R 4\u2032 , R 5 , R 5\u2032  and R 6  are H, or R 4 , R 4\u2032 , R 5\u2032 , R 6  are H and R 5  is halo, or R 4 , R 4\u2032 , R 5 , R 5\u2032  are H and R 6  is halo, cyano, C1-C3 alkyl, C1 haloalkyl, or R 4\u2032 , R 5\u2032 , R 6  are H and R 4 , R 5  are halo, or R 4 , R 4\u2032 , R 5\u2032  are H and R 5 , R 6  are independently halo, or R 4 , R 4\u2032  are H and R 5 , R 5\u2032 , R 6  are halo, and Ar 2  is, quinolin-2-yl, isoquinolin-3-yl, 8-haloquinolin-2-yl, benzothiazol-2-yl, 4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 88.0
- Lexical Diversity: 1.05882
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14349595', '14799208', '13627091', '15259922', '15205304']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8158399186282475
- 35 USC 102 Novelty (BERT): 0.6171872555393021
- Combined Prediction Score: 0.7959746523193529
- Mean Citation Score: 548.391766
- Max Citation Score: 607.86743
- Similarity Product: 484.3203731044448

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test