PATENT CLAIM ANALYSIS

Application Number: 16090726
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-03
Patent Classification: ["514", "005200"]

Abstract:
Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.

Claim (Index 2):
The compound of  claim 1 , selected from Formula I: wherein: R 1  is selected from H, phenyl, benzyl, benzyloxy, C 2 -C 4  arylalkyl, C 1 -C 4  alkylcycloalkyl, benzamido, polycyclic heterocycle, or branched or unbranched C 1 -C 6  alkyl; R 2  is selected from H, benzyl, or C 2 -C 4  arylalkenyl; or R 1  and R 2  combine to form phenyl; provided that R 1  and R 2  are not both H; R 3  is H, benzyl or lysine side chain; R 4  is a five membered saturated ring substituted with one C(O)NH 2  group or a six membered saturated or aromatic ring substituted with one C(O)NH 2  group, a heterocycleoalkyl substituted with one C(O)NH 2  group, C 1 -C 3  amidoalkyl, a bridged bicyclic ring system substituted with one C(O)NH 2  group, a cyclic imide, or CH(Ph)-CH\u2014C(O)NH 2 , with the proviso that if R 1  is benzamido, R 4  is either not a five membered saturated ring substituted with one C(O)NH 2  group or a six membered saturated or aromatic ring substituted with one C(O)NH 2  group or R 5  is C 1 -Cr alkyl; and R 5  is H, C 1 -C 3  alkyl, or benzyl; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 97.0
- Lexical Diversity: 1.52239
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15475227', '11018049', '15465218', '10799324', '11933056']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7694971075912461
- 35 USC 102 Novelty (BERT): 0.49095978525477
- Combined Prediction Score: 0.7416433753575985
- Mean Citation Score: 204.930786
- Max Citation Score: 207.6844
- Similarity Product: 149.04655335183145

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test