PATENT CLAIM ANALYSIS

Application Number: 15939850
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["424", "190100"]

Abstract:
Cold spot genes of  S. pneumoniae  are disclosed that encode surface proteins that are universally conserved among known strains and have exceptionally low incidence of allelic variation. Cold spot polypeptides encoded by the genes that are antigenic on the  S. pneumoniae  cells on which they are expressed are candidates for immunogenic compositions capable of eliciting antibodies able to react with all or nearly all strains of  S. pneumoniae,  thus providing an improvement over currently available  S. pneumoniae  vaccines that protect inoculated individuals against a maximum of about 23 of the 94 or so known serotypes of  S. pneumonia.

Claim (Index 6):
The immunogenic composition of  claim 1 , wherein said cold spot polypeptide is selected from the group set forth in the following table: Cold Spot Polypeptide (GenBank Designation in protein length TIGR4 Genomic Sequence) SEQ ID NO: (aa) SP_2207 SEQ ID NO: 274 220 SP_2223 SEQ ID NO: 276 276 SP_2226 SEQ ID NO: 277 122 SP_0005 SEQ ID NO: 278 189 SP_0007 SEQ ID NO: 279 88 SP_0008 SEQ ID NO: 280 122 SP_0010 SEQ ID NO: 281 422 SP_0016 SEQ ID NO: 283 112 SP_0020 SEQ ID NO: 284 155 SP_0021 SEQ ID NO: 285 147 SP_0024 SEQ ID NO: 286 165 SP_0030 SEQ ID NO: 287 108 SP_0037 SEQ ID NO: 288 330 SP_0048 SEQ ID NO: 291 181 SP_0050 SEQ ID NO: 292 515 SP_0053 SEQ ID NO: 293 162 SP_0057 SEQ ID NO: 294 1,312 SP_1847 SEQ ID NO: 297 193 SP_1850 SEQ ID NO: 298 254 SP_1855 SEQ ID NO: 299 345 SP_1865 SEQ ID NO: 300 354 SP_1897 SEQ ID NO: 301 419 SP_1923 SEQ ID NO: 305 471 SP_1937 SEQ ID NO: 306 318 SP_1948 SEQ ID NO: 308 74 SP_1949 SEQ ID NO: 309 62 SP_1954 SEQ ID NO: 310 467 SP_1955 SEQ ID NO: 311 103 SP_1980 SEQ ID NO: 312 308 SP_1990 SEQ ID NO: 313 186 SP_1991 SEQ ID NO: 314 257 SP_1994 SEQ ID NO: 315 404 SP_1997 SEQ ID NO: 316 462 SP_2010 SEQ ID NO: 318 731 and natural allelic variants thereof.

Metadata:
- Claim Count in Document: 18.0
- Percentile: 90.0
- Lexical Diversity: 1.44286
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['11513421', '12826084', '09590991', '10067385', '13355468']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7968399188563307
- 35 USC 102 Novelty (BERT): 0.5318628674820244
- Combined Prediction Score: 0.7703422137189001
- Mean Citation Score: 344.09956
- Max Citation Score: 359.8454
- Similarity Product: 217.7168334683537

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test