PATENT CLAIM ANALYSIS

Application Number: 15917050
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["424", "277100"]

Abstract:
The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of cancer, for example glioblastoma.

Claim (Index 10):
A biodiffusion chamber for implantation into a subject having brain cancer, the biodiffusion chamber comprising:\n (a) irradiated tumor cells,\n wherein the tumor cells comprise adherent cells obtained from the subject's tumor tissue; \n wherein the tumor cells are pre-incubated with insulin-like growth factor receptor-1 antisense oligodeoxynucleotide (IGF-1R AS ODN) prior to encapsulation within the chamber; and \n (b) irradiated IGF-1R AS ODN wherein the IGF-1R AS ODN has the sequence of SEQ ID NO:1; wherein the ratio of tumor cells to IGF-1R AS ODN in the chamber is in a range from about 3.75\u00d710 5  cells:\u03bcg AS ODN to about 6.25\u00d710 5  cells: \u03bcg AS ODN.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 90.0
- Lexical Diversity: 1.53947
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15867000', '15095877', '12286291', '12582013', '12286158']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7221669898467515
- 35 USC 102 Novelty (BERT): 0.579819067357533
- Combined Prediction Score: 0.7079321975978298
- Mean Citation Score: 338.293292
- Max Citation Score: 517.3965
- Similarity Product: 398.505391198933

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test