PATENT CLAIM ANALYSIS

Application Number: 15861399
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "233200"]

Abstract:
The present invention relates to novel fused Imidazobenzothiazole derivatives, their pharmaceutically acceptable salts, and their isomers, steroisomers, atropisomers, conformers, tautomers, polymorphs, hydrates, solvates and N-oxide. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

Claim (Index 3):
The method according to  claim 1 , wherein the compound of formula (I) is selected from the group consisting of:\n 7-[4-({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]-N-[2-(morpholin-4-yl)ethyl]imidazo[2,1-b][1,3]benzothiazole-2-carboxamide 7-[4-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]-N-[2-(morpholin-4-yl)ethyl]imidazo[2,1-b][1,3]benzothiazole-2-carboxamide 7-[4-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]-N-(2-hydroxy-1-phenylethyl)imidazo[2,1-b][1,3]benzothiazole-2-carboxamide 7-[4-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]-N-(2-hydroxyethyl)imidazo[2,1-b][1,3]benzothiazole-2-carboxamide ethyl 7-[4-({[3-tert-butyl-1-(3-chloro-4-methoxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate 7-[4-({[3-tert-butyl-1-(3-chloro-4-methoxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylic acid 7-[4-({[3-tert-butyl-1-(3-chloro-4-methoxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]-N-(2-hydroxyethyl)imidazo[2,1-b][1,3]benzothiazole-3-carboxamide 7-[4-({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylic acid 7-{[4-({[3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]sulfanyl}imidazo[2,1-b][1,3]benzothiazole-3-carboxylic acid 7-{[4-({[3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]sulfanyl}imidazo[2,1-b][1,3]benzothiazole-3-carboxylic acid 7-{[4-({[3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]sulfanyl}-N-(2-hydroxyethyl)imidazo[2,1-b][1,3]benzothiazole-3-carboxamide ethyl 7-{2-[({[3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}imidazo[2,1-b][1,3]benzothiazole-3-carboxylate 7-{2-[({[3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}imidazo[2,1-b][1,3]benzothiazole-3-carboxylic acid 7-{2-[({[3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}-N-(2-hydroxyethyl)imidazo[2,1-b][1,3]benzothiazole-3-carboxamide 1-[3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-3-(4-{[3-(hydroxymethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}phenyl)urea 1-[3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(hydroxymethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea ethyl 7-{2-[({[3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}imidazo[2,1-b][1,3]benzothiazole-3-carboxylate 1-[3-tert-butyl-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(4-{[3-(hydroxymethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]sulfanyl}phenyl)urea 7-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}imidazo[2,1-b][1,3]benzothiazole-3-carboxylic acid 7-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}-N-(2-hydroxyethyl)imidazo[2,1-b][1,3]benzothiazole-3-carboxamide 7-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}-N-(1,3-dihydroxypropan-2-yl)imidazo[2,1-b][1,3]benzothiazole-3-carboxamide 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(hydroxymethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2[(3-{[(2-hydroxyethyl)sulfanyl]methyl}imidazo[2,1-b][1,3]benzothiazol-7-yl)oxy]benzyl}urea 7-({2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenyl}sulfanyl)imidazo[2,1-b][1,3]benzothiazole-3-carboxylic acid ethyl 7-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[4-({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(4-{[3-(hydroxymethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}phenyl)urea 7-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}-N-(2-hydroxyethyl)-N-methylimidazo[2,1-b][1,3]benzothiazole-3-carboxamide 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(thiomorpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea ethyl{[7-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}imidazo[2,1-b][1,3]benzothiazol-2-yl)methyl]sulfanyl}acetate 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(methoxymethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2-[( 3 -{[(2-hydroxyethyl)(methyl)amino]methyl}imidazo[2,1-b][1,3]benzothiazol-7-yl)oxy]benzyl}urea N-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-4-{[3-(morpholin-4-ylcarbonyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzamide methyl{[(7-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}imidazo[2,1-b][1,3]benzothiazol-3-yl)methyl]sulfanyl}acetate 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(morpholin-4-ylcarbonyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(methoxymethyl)-2-methylimidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-{[3-(hydroxymethyl)-2-methylimidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 2-methoxyethyl(7-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}imidazo[2,1-b][1,3]benzothiazol-3-yl)carbamate 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[2-methyl-3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 7-(4{[(2-hydroxy-1-phenylethyl)carbamoyl]amino}phenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylic acid ethyl 7-[2-({[(2-hydroxy-1-phenylethyl)carbamoyl]amino}methyl) phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-(4-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbamoyl]amino}phenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[2-({[(3-chloro-4-methoxyphenyl)carbamoyl]amino}methyl)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[2-({[(3,5-dimethoxyphenyl)carbamoyl]amino}methyl) phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-(2-{[(cyclohexylcarbamoyl)amino]methyl}phenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino) phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate 1-(3-chloro-4-methoxyphenyl)-3-(2-{[3-(methoxymethyl)-2-methylimidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-(2-{[3-(methoxymethyl)-2-methylimidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-(3-tert-butyl-1,2-oxazol-5-yl)-3-(2-{[3-(methoxymethyl)-2-methylimidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea ethyl 7-(2-formylphenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[2-(hydroxymethyl)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[2-(chloromethyl)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[2-(azidomethyl)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[2-(aminomethyl)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate hydrochloride 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[(cyclopropylmethoxy)methyl]imidazo[2,1-b][1,3]benzothiazol-7-yl}oxy)benzyl]urea 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(chloromethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea ethyl 7-[(4-nitrophenyl)sulfanyl]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[(4-aminophenyl)sulfanyl]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-{[4-({[3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]sulfanyl}imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-(4-nitrophenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-(4-aminophenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylate 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(ethoxymethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(5-methyl-1,3-oxazol-2-yl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[(4-hydroxypiperidin-1-yl)methyl]imidazo[2,1-b][1,3]benzothiazol-7-yl}oxy)benzyl]urea methyl 7-(2-{[({5-tert-butyl-2-methoxy-3-[methyl(methyl sulfonyl)amino]phenyl}carbamoyl)amino]methyl}phenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[2-({[(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)carbamoyl]amino}methyl)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-(2-{[(propylcarbamoyl)amino]methyl}phenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-(2-{[(piperidin-4-ylcarbamoyl)amino]methyl}phenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-[2-({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenoxy]imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]-5-methylphenoxy}-5-methylimidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-{[3-({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 7-{[4-({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}imidazo[2,1-b][1,3]benzothiazole-3-carboxylate N-(5-tert-butyl-2-methoxy-3-{[(2-{[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl) carbamoyl]amino}phenyl) methanesulfonamide N-(5-tert-butyl-2-methoxy-3-{[(2-{[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)carbamoyl]amino}phenyl) ethanesulfonamide N-(5-tert-butyl-2-methoxy-3-{[(2-{[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)carbamoyl]amino}phenyl)-N-methylethanesulfonamide N-(5-tert-butyl-2-methoxy-3-{[(2-{[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)carbamoyl]amino}phenyl)-N-methylmethanesulfonamide methyl 7-{4-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]phenoxy}imidazo[2,1-b][1,3]benzothiazole-3-carboxylate ethyl 6-{2-[({[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)methyl]-4-fluorophenoxy}pyrrolo[2,1-b][1,3]benzothiazole-1-carboxylate ethyl 7-(2-{[(phenoxycarbonyl)amino]methyl}phenoxy) imidazo[2,1-b][1,3]benzothiazole-3-carboxylate 4-(3-tert-butyl-5-{[(2-{[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)carbamoyl]amino}-1H-pyrazol-1-yl)-2-chlorophenyl beta-D-glucopyranosiduronic acid 4-(3-tert-butyl-5-{[(2-{[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)carbamoyl]amino}-1H-pyrazol-1-yl)-2-chlorophenyl hydrogen sulfate 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-({3-[(4-oxidomorpholin-4-yl)methyl]imidazo[2,1-b][1,3]benzothiazol-7-yl}oxy)benzyl]urea 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(morpholin-4-ylmethyl)-1-oxidoimidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea: Dihydrochloride 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]oxy}benzyl)urea: Dimethanesulfonate ethyl 6,8-bis(acetylamino)-7-(4-nitrophenoxy)imidazo[2,1-b][1,3]benzothiazole-3-carboxylate and 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-[2-(imidazo[2,1-b][1,3]benzothiazol-7-yloxy)benzyl]urea and pharmaceutically acceptable salts thereof.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 86.0
- Lexical Diversity: 1.7619
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15128886', '15505902', '13639959', '15689075', '14424361']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7989737927642019
- 35 USC 102 Novelty (BERT): 0.6295857882418375
- Combined Prediction Score: 0.7820349923119655
- Mean Citation Score: 399.13778
- Max Citation Score: 583.3345
- Similarity Product: 534.1956769186258

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test