PATENT CLAIM ANALYSIS

Application Number: 15868331
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["546", "185000"]

Abstract:
The present disclosure is related to an improved and efficient process for preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine which comprises: (a) N-acylation of 3-Amino-4-methyl pyridine; (b) Quarternization of 3-Acetylamino-4-methyl pyridine using benzyl halide; (c) Partial reduction of quarternized 3-Acetylamino-4-methyl pyridine by Sodium borohydride in Methanol or water; (d) Hydrolysis of partially reduced product to 1-Benzyl-4-methylpiperidin-3-one in presence of acid; (e) Reductive amination of 1-Benzyl-4-methylpiperidin-3-one using Methanolic methylamine in presence of Titanium(IV) isopropoxide in Methanol; (f) Resolution of 1-Benzyl-4-methylpiperidin-3-yl)-methylamine using Ditoluoyl (L) tartaric acid to get (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine. The disclosure is also related to novel intermediates: wherein R, R′ and X are as described in the specification.

Claim (Index 10):
The process of  claim 1 , wherein the acid or mixture of acids of part (iv) is selected from hydrochloric acid, sulfuric acid, phosphoric acid, trifluoroacetic acid, trichloroacetic acid, substituted halo acetic acid, acetic acid, HI, HBr, mineral acids, organic acids, aqueous solutions thereof, or a mixture of two or more thereof.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 86.0
- Lexical Diversity: 1.76829
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14891028', '16306941', '10310078', '10720600', '11032990']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8104353473294579
- 35 USC 102 Novelty (BERT): 0.6154683241572922
- Combined Prediction Score: 0.7909386450122413
- Mean Citation Score: 373.796776
- Max Citation Score: 579.4216299999998
- Similarity Product: 511.0290346365349

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test