PATENT CLAIM ANALYSIS

Application Number: 16127772
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "242000"]

Abstract:
The present invention relates to compounds capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds, and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Claim (Index 1):
A compound of Formula A1: or a pharmaceutically acceptable salt thereof, wherein:\n L is O, S, or absent; \n X 1  is N or CR X1 ; \n X 2  is N or CR X2 ; \n Y 1  is N or CR Y1 ; \n Y 2  is N or CR Y2 ; \n wherein not more than 3 of X 1 , X 2 , Y 1 , and Y 2  are simultaneously N; \n R 1  is C 6-10  aryl, C 3-14  cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from Cy 1 , halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 NR c1 R d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , and S(O) 2 NR c1 R d1 , wherein the C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with 1, 2, or 3 substituents independently selected from Cy 1 , halo, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 NR c1 R d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 NR c1 C(O)NR c1 R d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , and S(O) 2 NR c1 R d1 ; \n R 2a , R 2b , R 4a , R 4b , R 5a , R 5b , R 7a , and R 7b  are each independently selected from H, C 1-4  alkyl, C 1-4  alkoxy, amino, hydroxy, C 3 -s cycloalkyl and C 1-4  alkylamino; \n R 3  and R 6  are each independently selected from H, F, or C 1-4  alkyl; \n R 8  and R 9  are each independently selected from H, halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-4  haloalkyl, OR a2 , SR a2 , C(O)R b2 , C(O)NR 2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , NR c2 R d2 , NR c2 C(O)R b2  NR c2 C(O)OR a2  NR c2 C(O)NR c2 R d2  NR c2 S(O)R b2  NR c2 S(O) 2 R b2  NR c2 S(O) 2 NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 NR c2 R d2  wherein the alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR 2 R d2 , C(\u2550NR e2 )NR c2 R d2 , NR c2 C(\u2550NR e2 )NR c2 R d2  NR c2 R d2  NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2  NR c2 S(O)R b2 , NR c2 S(O) 2 R b2  NR c2 S(O) 2 NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 NR 2 R d2 ; \n wherein at least one of R 8  and R 9  is other than H; \n R X1 , R X2 , R Y1 , and R Y2  are each independently selected from H, Cy 2 , halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, CN, NO 2 , OR a3 , SR a3 , C(O)R b3 , C(O)NR 3 R d3 , C(O)OR a3  OC(O)R b3 , OC(O)NR 3 R d3 , C(\u2550NR e3 )NR c3 R d3  NR c3 C(\u2550NR e3 )NR 3 R d3 , NR c3 R d3 , NR c3 (O)R b3  NR c3 C(O)OR a3 , NR 3 C(O)NR c3 R d3 , NR 3 S(O)R b3 , NR c3 S(O) 2 R b3 , NR 3 S(O) 2 NR 3 R d3 , S(O)R b3 , S(O)NR 3 R d3 , S(O) 2 R b3 , and S(O) 2 NR 3 R d3 , wherein the C 1-6  alkyl, C 2-6  alkenyl, and C 2-6  alkynyl are optionally substituted with 1, 2, or 3 substituents independently selected from Cy 2 , halo, CN, NO 2 , OR a3 , SR a3 , C(O)R b3 , C(O)NR 3 R d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R d3 , C(\u2550NR e3 )NR c3 R d3 , NR 3 C(\u2550NR e3 )NR c3 R d3 , NR 3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R d3 , NR c3 S(O)R b3  NR c3 S(O) 2 R b3 , NR c3 S(O) 2 NR c3 R d3 , S(O)R b3 , S(O)NR 3 R d3  S(O) 2 R b3 , and S(O) 2 NR 3 R d3 ; \n each Cy 1  is independently selected from C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 substituents independently selected from halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, 4-10 membered heterocycloalkyl-C 1-4  alkyl, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , NR c1 R d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , and S(O) 2 NR c1 R d1 ; \n each Cy 2  is independently selected from C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 substituents independently selected from halo, C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 6 -10 aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, 4-10 membered heterocycloalkyl-C 1-4  alkyl, CN, NO 2 , OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R d3 , C(\u2550NR e3 )NR 3 R d3 , NR c3 C(\u2550NR e3 )NR c3 R d3  NR c3 R d3  NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R d3  NR c3 S(O)R b3  NR c3 S(O) 2 R b3 , NR c3 S(O) 2 NR c3 R d3 S(O)R b3 , S(O)NR 3 R d3 , S(O) 2 R b3 , and S(O) 2 NR 3 R d3 ; \n each R a1 , R b1 , R e1 , R d1 , R a3 , R b3 , R c3 , and R d3  is independently selected from H, C 1-6  alkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl, wherein said C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl of said R a1 , R b1 , R d1 , R d1 , R a3 , R b3 , R c3 , and R d3  are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, C 1-4  alkyl, C 1-4  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, CN, OR a4 , SR a4 , C(O)R b4 , C(O)NR 4 R d4 , C(O)OR a4 , OC(O)R b4 , OC(O)NR c4 R d4 , NR c4 R d4  NR c4 C(O)R b4 , NR c4 C(O)NR c7 R d4  NR c4 C(O)OR a4 , C(\u2550NR e4 )NR 4 R d4 , NR c4 C(\u2550NR e4 )NR c3 R d4 S(O)R b4 , S(O)NR 4 R d4 , S(O) 2 R b4 , NR c4 S(O) 2 R b4  NR c4 S(O) 2 NR 4 R d4 , and S(O) 2 NR 4 R d4 ; \n or R c1  and R d2  together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from CN, halo, C 1-4  alkyl, C 1-4  haloalkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, CN, OR a4 , SR a4 , C(O)R b4 , C(O)NR 4 R d4 , C(O)OR a4 , OC(O)R b4 , OC(O)NR c4 R d4 , NR c4 R d4  NR c4 C(O)R b4  NR c4 C(O)NR c7 R d4  NR c4 C(O)OR a4 , C(\u2550NR e4 )NR 4 R d4 , NR c4 C(\u2550NR e4 )NR c3 R d4 S(O)R b4 , S(O)NR 4 R d4 , S(O) 2 R b4 , NR c4 S(O) 2 R b4  NR c4 S(O) 2 NR c4 R d4 , and S(O) 2 NR 4 R d4 ; \n or R c3  and R d3  together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from CN, halo, C 1-4  alkyl, C 1-4  haloalkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, CN, OR a4 , SR a4 , C(O)R b4 , C(O)NR 4 R d4 , C(O)OR a4 , OC(O)R b4 , OC(O)NR c4 R d4 , NR c4 R d4  NR c4 C(O)R b4  NR c4 C(O)NR c7 R d4  NR c4 C(O)OR a4 , C(\u2550NR e4 )NR 4 R d4 , NR c4 C(\u2550NR e4 )NR c3 R d4 S(O)R b4 , S(O)NR 4 R d4 , S(O) 2 R b4 , NR c4 S(O) 2 R b4  NR c4 S(O) 2 NR 4 R d4 , and S(O) 2 NR 4 R d4 ; \n each R a2 , R b2 , R c2 , and R d2  is independently selected from H and C 1-4  alkyl; \n each R a4 , R b4 , R c4 , and R d4  is independently selected from H, C 1-6  alkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl, wherein said C 1-6  alkyl, C 1-6  haloalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 6-10  aryl, C 3-7  cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10  aryl-C 1-4  alkyl, C 3-7  cycloalkyl-C 1-4  alkyl, 5-10 membered heteroaryl-C 1-4  alkyl, and 4-10 membered heterocycloalkyl-C 1-4  alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, and C 1-6  haloalkoxy; and \n each R e1 , R e2 , R 3 , and R e4  is independently selected from H, C 1-4  alkyl, and CN, \n wherein any aforementioned heteroaryl or heterocycloalkyl group comprises 1, 2, 3, or 4 ring-forming heteroatoms independently selected from O, N, and S; and \n wherein one or more ring-forming C or N atoms of any aforementioned heterocycloalkyl group is optionally substituted by an oxo (\u2550O) group.

Metadata:
- Claim Count in Document: 128.0
- Percentile: 97.0
- Lexical Diversity: 1.61111
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14554263', '14155134', '15358371', '14554306', '15398907']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7533095389725273
- 35 USC 102 Novelty (BERT): 0.5223338816416117
- Combined Prediction Score: 0.7302119732394357
- Mean Citation Score: 305.715376
- Max Citation Score: 310.1815200000001
- Similarity Product: 239.5145674605132

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test