PATENT CLAIM ANALYSIS

Application Number: 15946505
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["435", "188000"]

Abstract:
The present disclosure relates to compositions and methods for treating Sanfilippo syndrome (also known as Sanfilippo disease type D, Sanfilippo D, mucopolysaccharidosis type IIID, MPS IIID). The method can entail injecting to the spinal fluid of a MPS IIID patient an effective amount of a composition comprising a recombinant human acetylglucosamine-6-sulfatase (GNS) protein comprising the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and having the enzymatic activity of the human GNS protein. The composition can be provided in an artificial cerebrospinal fluid. About 1 mg to about 100 mg of the recombinant polypeptide may be administered to the patient once every 2 weeks to 6 months.

Claim (Index 1):
A method of treating mucopolysaccharidosis type IIID (MPS IIID) in a human patient in need thereof, comprising injecting to the spinal fluid of the patient an effective amount of a composition comprising a recombinant polypeptide comprising the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence (a) having at least 95% sequence identity to SEQ ID NO: 1 and (b) having the enzymatic activity of human acetylglucosamine-6-sulfatase (GNS), wherein the composition is provided in an artificial cerebrospinal fluid.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 91.0
- Lexical Diversity: 1.7125
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14573907', '13188907', '14281538', '12629029', '14924405']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6020982807381435
- 35 USC 102 Novelty (BERT): 0.5027427814501351
- Combined Prediction Score: 0.5921627308093427
- Mean Citation Score: 239.725566
- Max Citation Score: 242.75977000000003
- Similarity Product: 153.75611455128015

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test