PATENT CLAIM ANALYSIS

Application Number: 16056339
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-11
Patent Classification: ["210", "656000"]

Abstract:
A chromatography system with a main column comprising a chromatography resin, a first guard column and a second guard column, wherein the first guard column is connected to a first end of the main column, the second guard column is connected to a second end of the main column and the bed volumes of said first and second guard columns are each less than about 50% of the bed volume of the main column.

Claim (Index 10):
A method for use with a chromatography apparatus, the method comprising:\n generating, by a first detector disposed between a main column and a first guard column of the chromatography apparatus, in response to a feed stream passing through the first guard column, a first signal including a first signal's first plateau and a first signal's second plateau, the first signal being a time-varying signal and the first signal's first plateau occurring before the first signal's second plateau, wherein the first signal is indicative of species of the feed stream binding and passing through the first column, and wherein the first signal's first plateau is indicative of non-adsorbing species breaking through the first column and the first signal's second plateau is indicative of all the substance in the feed stream; generating, by a second detector disposed between the main column and a second guard column of the chromatography apparatus, a second signal including a second signal's plateau, wherein the second signal is indicative of all of the substances included in an effluent stream of the main column; determining, by a programmable logic controller of the chromatography apparatus, (i) a first breakthrough point based on a first difference between the first signal and the second signal reaching a first threshold and (ii) a second breakthrough point based on a second difference between the first signal and the second signal reaching a second threshold; wherein the determining includes conducting a first comparison between the first signal and the second signal, wherein the first difference corresponds to the first comparison reaching the first threshold; wherein the second difference is based on a second comparison between the first signal and the second signal, wherein the second difference corresponds to the second comparison reaching the second threshold; wherein the first threshold and second thresholds are each a percentage of a difference between the first signal's second plateau and the second signal's plateau; and wherein the second threshold is different than the first threshold.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 96.0
- Lexical Diversity: 2.32353
- Patent Class: 210.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14169320', '14627559', '14645138', '15323778', '13866060']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.752044087668073
- 35 USC 102 Novelty (BERT): 0.4788543962614588
- Combined Prediction Score: 0.7247251185274116
- Mean Citation Score: 139.29720000000003
- Max Citation Score: 160.94658
- Similarity Product: 108.13446771763088

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test