PATENT CLAIM ANALYSIS

Application Number: 15760284
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "210210"]

Abstract:
The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Claim (Index 1):
A compound represented by: wherein Y is S(O) y , wherein y is 2; R Z  is H; R m\u2032  and R m  are H; R c  is H; R 77  is selected from the group consisting of H, halogen, cyano, and C 1-6 alkyl; R 78  is selected from the group consisting of C 1-6  alkyl substituted with one, two, or three substituents each independently selected from the group consisting of halogen, hydroxyl, and cyano; phenyl substituted with one, two, three or four substituents each independently selected from the group consisting of R 73 ; and X 2 \u2014C 1-6 alkylene-R 79 ; X 2  is selected from the group consisting of S(O) w  (wherein w is 0, 1, or 2), O, \u2014C(O)\u2014 and NR\u2032; R 79  is selected from the group consisting of H, hydroxyl, halogen, C 1-6 alkyl, \u2014C(O)\u2014O\u2014C 1-6 alkyl, heterocycle (optionally substituted by one or more substituents selected from the group consisting of halogen, NR\u2032R\u2032, \u2014C(O)\u2014O\u2014C 1-6 alkyl, carboxy and C 1-6 alkyl), \u2014C(O)\u2014NR\u2032R\u2033, \u2014C (\u2550NH)\u2014NR\u2032R\u2033, heteroaryl, phenyl (optionally substituted by one or more substituents selected from the group consisting of halogen, NR\u2032R\u2032, \u2014C(O)\u2014O\u2014C 1-6 alkyl, carboxy, C 1-6 alkoxy, and C 1-6 alkyl), C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, carboxy, NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, C 3-6 cycloalkyl, \u2014NR\u2032\u2014C(O)\u2014 C 1-6 alkyl, NR\u2032\u2014C(O)\u2014 O\u2014C 1-6 alkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2), and \u2014NR\u2032\u2014S(O) w \u2014 C 1-6 alkyl (where w is 0, 1 or 2)); R 73  is selected from the group consisting of H, halogen, hydroxyl, nitro, cyano, carboxy, oxo, C 1-6 alkyl, \u2014C(O)\u2014O\u2014C 1-6 alkyl, heterocycle (optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxyl, oxo, NR\u2032R\u2032, \u2014C(O)\u2014O\u2014C 1-6 alkyl, carboxy and C 1-6 alkyl), \u2014C(O)\u2014NR\u2032\u2014C 1-6 alkyl, \u2014C(\u2550NH)\u2014NR\u2032R\u2033, heteroaryl, phenyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, carboxy, oxo, NR\u2032R\u2033, \u2014C(O)\u2014C 1-6 alkyl, \u2014C 3-6 cycloalkyl, NR\u2032\u2014C(O)\u2014 C 1-6 alkyl, NR\u2032\u2014C(O)\u2014 O\u2014C 1-6 alkyl, \u2014S(O) w \u2014C 1-6 alkyl (where w is 0, 1 or 2), \u2014S(O) w \u2014NR\u2032R\u2033 (where w is 1, 2 or 3), \u2014NR\u2032\u2014S(O) w \u2014 C 1-6 alkyl (where w is 0, 1 or 2), C(O)\u2014NR\u2032\u2014 C 1-6 alkyl, C(O)\u2014C 1-3 alkylene-NR\u2032\u2014 C(O)\u2014O\u2014 C 1-6 alkyl, X 2 \u2014 R 79 ; and X 2 \u2014C 1-6 alkylene-R 79 ; R\u2032 is selected, independently for each occurrence, from H, methyl, ethyl, cyclopropyl, cyclobutyl, and propyl; R\u2033 is selected, independently for each occurrence, from H, methyl, ethyl, propyl, (optionally substituted by hydroxyl), butyl (optionally substituted by hydroxyl), \u2014C(O)-methyl and \u2014C(O)-ethyl, or R\u2032 and R\u2033 taken together with the nitrogen to which they are attached may form a 4-7 membered heterocycle optionally substituted by one, two or more substituents selected from the group consisting of halogen, hydroxyl, NH 2 , \u2014C(O)\u2014O\u2014C 1-3 alkyl, \u2014C(O)\u2014C 1-3 alkyl, carboxy, oxo, and C 1-3 alkyl; each of moieties R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10  is independently selected for each occurrence from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkynyl, C 2-6 alkenyl, halogen, hydroxyl, nitro, cyano, and NR\u2032R\u2033; wherein for each occurrence, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 3-6 cycloalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-3 alkoxy, NR\u2032R\u2033, \u2014NR\u2032\u2014S(O) w \u2014 C 1-2 alkyl (where w is 0, 1 or 2), NR\u2032\u2014C(O)\u2014C 1-3 alkyl, NR\u2032\u2014C(O)\u2014 O\u2014C 1-3 alkyl, and S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2); C 1-6 alkoxy may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C 1-3 alkyl, NR\u2032R\u2033, \u2014NR\u2032\u2014S(O) w \u2014 C 1-2 alkyl (where w is 0, 1 or 2), and S(O) w \u2014NR\u2032R\u2033 (where w is 0, 1 or 2); C 1-6 alkylene may be optionally substituted by a substituent selected from the group consisting of C 3-6 cycloalkyl, hydroxyl, cyano, and halogen; and pharmaceutically acceptable salts and N-oxides thereof.

Metadata:
- Claim Count in Document: 25.0
- Percentile: 90.0
- Lexical Diversity: 1.17949
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15125911', '15760343', '15030378', '15566633', '12785665']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8339685704184299
- 35 USC 102 Novelty (BERT): 0.5528274768475483
- Combined Prediction Score: 0.8058544610613417
- Mean Citation Score: 360.872362
- Max Citation Score: 418.14563
- Similarity Product: 385.3341446659636

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test