PATENT CLAIM ANALYSIS

Application Number: 15752900
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "449000"]

Abstract:
The present application is directed to transdermal formulations for the delivery of berberine compounds to a subject for the treatment of berberine-responsive diseases. In particular, the transdermal formulation comprises: (a) an aqueous phase comprising water and at least one water soluble emulsion stabilizer; (b) an oil phase comprising at least one emulsifier, at least one oil soluble emulsion stabilizer, at least one emollient comprising at least one flavonoid and at least one other emollient; wherein the oil and aqueous phases form an emulsion; (c) an external phase comprising at least one flavonoid containing-extract, at least one phospholipid-complexed flavonoid and at least one source of berberine or analog or derivative thereof; and optionally (d) at least one preservative phase.

Claim (Index 9):
The transdermal formulation of  claim 1 , wherein the berberine analog or derivative is selected from one or more of berberine, berberine sulfate, berberine bisulfate, berberine hemisulfate, berberine chloride, jatrorrhizine, palmatine, coptisine, 8-ethyl-12-bromoberberine, 8-ethylberberine, 8-methoxyberberine, 8-methylberberine, 8-n-butyl-12-bromoberberine, 8-n-butylberberine, 8-n-hexyl-12-bromoberberine, 8-n-propyl-12-bromoberberine, 8-n-propylberberine, 8-phenyl-12-bromoberberine, 8-phenylberberine, 9-O-acetylberberrubine, 9-O-benzoylberberrubine, 9-O-ethylberberrubine, 9-O-valerylberberrubine, 9-demethylberberine, 9-demethylpalmatine, 9-O-ethyl-berberrubine, 9-O-ethyl-13-ethylberberrubine, 9-lauroylberberrubine chloride, 12-bromoberrubine, 13-ethoxyberberine, 13-ethylberberine, 13-ethylpalmatine, 13-hydroxyberberine, 13-methoxyberberine, 13-methylberberine, 13-methylberberrubine, 13-methyldihydroberberine N-methyl salt, 13-methylpalmatine, 13-n-butylberberine, 13-n-butylpalmatine, 13-n-hexylberberine, 13-n-hexylpalmatine, 13-n-propylberberine, 13-n-propylpalmatine, palmatrubine, dihydroberberines and tetrahydroberberines.

Metadata:
- Claim Count in Document: 34.0
- Percentile: 88.0
- Lexical Diversity: 2.20968
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15681950', '14576476', '15022951', '12258341', '14857772']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7077701667967394
- 35 USC 102 Novelty (BERT): 0.5016868481495368
- Combined Prediction Score: 0.6871618349320192
- Mean Citation Score: 204.80555400000003
- Max Citation Score: 206.40686
- Similarity Product: 129.7835719370675

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test