PATENT CLAIM ANALYSIS

Application Number: 16034558
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-03
Patent Classification: ["546", "158000"]

Abstract:
The invention relates generally to novel EPAC1 activators, such as Formula I and the preparation thereof as well as the use of EPAC1 activators as human immunodeficiency virus (HIV) latency reversal agents (LRAs).

Claim (Index 1):
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein: is a group chosen from: (i) a substituted or unsubstituted indole of the following structure (Formula Ia): wherein said structure of Formula Ia is attached to the \u2014(C\u2550O)\u2014 group of Formula I via the 2-, 3-, 4, 5-, 6-, or 7-position ring carbon atom; (ii) a classical bioisostere of the indole ring; and (iii) a non-classical bioisostere of the indole ring chosen from: wherein said ring is attached to the \u2014(C\u2550O)\u2014 group of Formula I at any available site. R 2  is independently one or more substituents chosen from H, COR 4 , SO 2 R 4 , \u2014(O\u2550C)OR 4 , \u2014(O\u2550C)NHR 4 , C 1 -C 6  alkyl, \u2014CH 2 Ph, and C 1 -C 6  alkylamine; R 3  is independently one or more substituents chosen from H; C 1 -C 6 -alkoxy OH; halide; NO 2 ; C 1 -C 6  alkyl; \u2014(CH 2 ) n OH, wherein n is 1-8; and a 1,1-dioxidothiomorpholino group; an optionally fused substituted or unsubstituted group chosen from aryl, heteroaryl, cycloalkyl, \u03b2-lactam, \u03b3-lactam, \u03b4-lactam, \u03b5-lactam, and heterocycle; \u2014(C\u2550O)OR 4 ; \u2014(C\u2550O)NR 5 R 6 ; and \u2014NR 5 R 6 ; wherein R 4 , R 5 , and R 6  are independently chosen from H, C1-C6 alkyl, aryl, heteroaryl, cycloalkyl, heterocycle; R 4 , R 5  and R 6  are independently chosen from H, C 1 -C 6  alkyl, C 1 -C 7  cycloalkyl, cycloaryl and cycloheteroaryl.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 95.0
- Lexical Diversity: 1.25806
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13640732', '15847628', '14371075', '15313286', '15110000']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7624390831940144
- 35 USC 102 Novelty (BERT): 0.5177204620722589
- Combined Prediction Score: 0.7379672210818389
- Mean Citation Score: 261.35323200000005
- Max Citation Score: 266.34564
- Similarity Product: 166.4585794199252

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test