PATENT CLAIM ANALYSIS

Application Number: 16188982
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "640000"]

Abstract:
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.

Claim (Index 1):
A sterile container comprising:\n an antibacterial agent in solid form; and a compound of Formula (I) in dolid form having the structure: or a pharmaceutically acceptable salt thereof, wherein: Y is a 1-4 atom alkylene or 2-4 atom alkenylene linker, optionally substituted by one or more substituents selected from the group consisting of Cl, F, CN, CF 3 , \u2014R 9 , \u2014OR 9 , \u2014C(\u2550O)NR 9 R 10 , and \u2014C(\u2550O)OR 9 , wherein said alkylene or alkenylene linker is optionally fused to an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, or optionally substituted heterocyclyl; R 1  is selected from a group consisting of \u2014C 1-9 alkyl, \u2014C 2-9 alkenyl, \u2014C 2-9 alkynyl, \u2014NR 9 R 10 , \u2014C 1-9 alkylR 11 , \u2014C 2-9 alkenylR 11 , \u2014C 2-9 alkynylR 11 , -carbocyclyl-R 11 , \u2014CH(OH)C 1-9 alkylR 9 , \u2014CH(OH)C 2-9 alkenylR 9 , \u2014CH(OH)C 2-9 alkynylR 9 , \u2014CH(OH)carbocyclyl-R 9 , \u2014C(\u2550O)R 9 , \u2014C(\u2550O)C 1-9 alkylR 9 , \u2014C(\u2550O)C 2-9 alkenylR 9 , \u2014C(\u2550O)C 2-9 alkynylR 9 , \u2014C(\u2550O)C 2-9 carbocyclyl-R 9 , \u2014C(\u2550O)NR 9 R 10 , \u2014N(R 9 )C(\u2550O)R 9 , \u2014N(R 9 )C(\u2550O)NR 9 R 10 , \u2014N(R 9 )C(\u2550O)OR 9 , \u2014N(R 9 )C(\u2550O)C(\u2550NR 10 )R 9 , \u2014N(R 9 )C(\u2550O)C(\u2550CR 9 R 10 )R 9 , \u2014N(R 9 )C(\u2550O)C 1-4 alkylN(R 9 )C(\u2550O)R 9 , \u2014N(R 9 )C(\u2550NR 10 )R 9 , \u2014C(\u2550NR 10 )NR 9 R 10 , \u2014N\u2550C(R 9 )NR 9 R 10 , \u2014N(R 9 )SO 2 R 9 , \u2014N(R 9 )SO 2 NR 9 R 10 , \u2014N\u2550CHR 9 , optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, and optionally substituted heterocyclyl; R 6  is selected from a group consisting of H, \u2014C 1-9 alkyl, C 2-9 alkenyl, \u2014C 2-9 alkynyl, carbocyclyl, \u2014C 1-9 alkylR 11 , \u2014C 2-9 alkenylR 11 , \u2014C 2-9 alkynylR 11 , carbocyclyl-R 11 , \u2014C(\u2550O)OR 9 , \u2014C 1-9 alkylCO 2 R 9 , \u2014C 2-9 alkenylCO 2 R 9 , \u2014C 2-9 alkynylCO 2 R 9 , and -carbocyclyl-CO 2 R 9 , or alternatively:\n (i) R 6  and an R 7  are taken together with the atoms to which they are attached to form an optionally substituted carbocyclyl or optionally substituted heterocyclyl, or \n (ii) R 6  is absent when the carbon to which it is attached is a ring atom in an aryl or heteroaryl ring; \n each R 7  is independently selected from a group consisting of H, halo, \u2014C 1-9 alkyl, \u2014C 2-9 alkenyl, \u2014C 2-9 alkynyl, \u2014NR 9 R 10 , \u2014OR 9 , \u2014C 1-9 alkylCO 2 R 9 , \u2014C 2-9 alkenylCO 2 R 9 , \u2014C 2-9 alkynylCO 2 R 9 , and -carbocyclyl-CO 2 R 9 , or independently:\n (i) R 6  and an R 7  are taken together with the atoms to which they are attached to form an optionally substituted carbocyclyl or optionally substituted heterocyclyl, or \n (ii) R 7  and an R 8  are taken together with the atoms to which they are attached to form an optionally substituted carbocyclyl or optionally substituted heterocyclyl; \n each R 8  is independently selected from a group consisting of H, halo, \u2014C 1-9 alkyl, \u2014C 2-9 alkenyl, \u2014C 2-9 alkynyl, \u2014NR 9 R 10 , \u2014OR 9 , \u2014C 1-9 alkylCO 2 R 9 , \u2014C 2-9 alkenylCO 2 R 9 , \u2014C 2-9 alkynylCO 2 R 9 , -carbocyclyl-CO 2 R 9 , or independently:\n (i) an R 7  and an R 8  are taken together with the atoms to which they are attached to form an optionally substituted carbocyclyl or optionally substituted heterocyclyl, \n (ii) a geminal R 7  and R 8  together form \u2014C 2-9 alkenylenylCO 2 R 9 , or \n (iii) each R 8  attached to a ring atom forming part of an optionally substituted aryl is absent; \n each R 9  is independently selected from a group consisting of H, \u2014C 1-9 alkyl, C 2-9 alkenyl, \u2014C 2-9 alkynyl, carbocyclyl, \u2014C 1-9 alkylR 11 , \u2014C 2-9 alkenylR 11 , \u2014C 2-9 alkynylR 11 , -carbocyclyl-R 11 , optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, and optionally substituted heterocyclyl; each R 10  is independently selected from a group consisting of H, \u2014C 1-9 alkyl, \u2014OR 9 , \u2014CH(\u2550NH), \u2014C(\u2550O)OR 9 , optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, and optionally substituted heterocyclyl; each R 11  is independently selected from a group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, and optionally substituted heterocyclyl; X is selected from a group consisting of \u2014CO 2 R 12 , and a carboxylic acid isostere; R 12  is selected from a group consisting of H, C 1-9 alkyl, \u2014(CH 2 ) 0-3 \u2014R 11 , \u2014C(R 13 ) 2 OC(O)C 1-9 alkyl, \u2014C(R 13 ) 2 OC(O)R 11 , \u2014C(R 13 ) 2 OC(O)OC 1-9 alkyl and \u2014C(R 13 ) 2 OC(O)OR 11 ; each R 13  is independently selected from a group consisting of H and C 1-4 alkyl; and m is independently zero or an integer from 1 to 2, wherein each C 1-9 alkyl, C 2-9 alkenyl, and C 2-9 alkynyl is independently optionally substituted.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 98.0
- Lexical Diversity: 1.18519
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15935862', '15935782', '13205112', '13953647', '15015002']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8411041057068284
- 35 USC 102 Novelty (BERT): 0.6474984059605526
- Combined Prediction Score: 0.8217435357322008
- Mean Citation Score: 618.95506
- Max Citation Score: 640.4164
- Similarity Product: 574.8612713490725

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test