PATENT CLAIM ANALYSIS

Application Number: 15993090
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["536", "024500"]

Abstract:
The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the IKBKAP gene. Certain such compounds are useful for hybridizing to a portion of the IKBKAP gene, including but not limited to a portion of the IKBKAP gene in a cell. In certain embodiments, such hybridization results in modulation of splicing of the IKBKAP gene. In certain embodiments, the IKBKAP gene includes a mutation that results in defective splicing and a truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in a decrease in the amount of defective splicing and truncated IKAP protein. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the IKBKAP gene results in an increase in the amount of normal splicing and functional, full-length IKAP protein. In certain embodiments, oligonucleotides are used to treat Familial Dysautonomia.

Claim (Index 104):
A method of modulating splicing in an IKBKAP transcript in a cell comprising contacting the cell with a compound according to  claim 85 .

Metadata:
- Claim Count in Document: 60.0
- Percentile: 93.0
- Lexical Diversity: 2.85455
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14009782', '15315828', '15835698', '15835995', '15045999']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6771839359568893
- 35 USC 102 Novelty (BERT): 0.5315908748040588
- Combined Prediction Score: 0.6626246298416063
- Mean Citation Score: 377.0279
- Max Citation Score: 387.08127
- Similarity Product: 271.7967224916244

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test