PATENT CLAIM ANALYSIS

Application Number: 15902301
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["435", "189000"]

Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

Claim (Index 2):
The engineered ketoreductase polypeptide of  claim 1 , in which the ketoreductase polypeptide amino acid sequence further comprises one or more additional substitutions selected from:\n the residue corresponding to X3 is asparagine, aspartic acid, or tyrosine; the residue corresponding to X7 is glycine, histidine, serine or asparagine; the residue corresponding to X11 is isoleucine or threonine; the residue corresponding to X16 is threonine, alanine, valine, or glycine; the residue corresponding to X19 is isoleucine or valine; the residue corresponding to X23 is isoleucine or phenylalanine; the residue corresponding to X41 is serine, alanine, or valine; the residue corresponding to X45 is glutamic acid or glycine; the residue corresponding to X49 is lysine or arginine; the residue corresponding to X57 is isoleucine or valine; the residue corresponding to X60 is phenylalanine, valine, or threonine; the residue corresponding to X64 is alanine, serine, or threonine; the residue corresponding to X72 is lysine or arginine, particularly arginine; the residue corresponding to X82 is glycine or serine; the residue corresponding to X94 is alanine, valine, threonine, serine, or arginine; the residue corresponding to X95 is valine or alanine; the residue corresponding to X96 is asparagine, serine, proline, alanine, or glutamic acid; the residue corresponding to X97 is lysine, arginine or leucine; the residue corresponding to X106 is glutamic acid or aspartic acid; the residue corresponding to X108 is arginine or histidine; the residue corresponding to X111 is leucine or methionine; the residue corresponding to X117 is glycine or serine; the residue corresponding to X126 is isoleucine or valine; the residue corresponding to X127 is glutamine or arginine; the residue corresponding to X145 is aspartic acid or serine; the residue corresponding to X147 is phenylalanine, leucine or serine; the residue corresponding to X152 is threonine, serine, or methionine; the residue corresponding to X157 is asparagine, glutamine, threonine, serine, or aspartic acid; the residue corresponding to X163 is valine or isoleucine; the residue corresponding to X173 is aspartic acid or glycine; the residue corresponding to X177 is lysine or arginine; the residue corresponding to X192 is lysine, arginine or glutamic acid; the residue corresponding to X194 is proline, glycine, aspartic acid, arginine, or leucine; the residue corresponding to X198 is aspartic acid or glycine; the residue corresponding to X200 is proline, glutamic acid, or lysine; the residue corresponding to X206 is methionine or glutamine; the residue corresponding to X208 is glutamine, histidine or arginine; the residue corresponding to X210 is threonine or alanine; the residue corresponding to X211 is lysine or glutamic acid; the residue corresponding to X214 is methionine, valine or threonine, or serine; the residue corresponding to X217 is isoleucine or phenylalanine; the residue corresponding to X223 is isoleucine or valine; and the residue corresponding to X226 is isoleucine or valine.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 88.0
- Lexical Diversity: 1.43243
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15184018', '12197286', '13110789', '15711070', '15211505']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7653705385187761
- 35 USC 102 Novelty (BERT): 0.6519117920336853
- Combined Prediction Score: 0.754024663870267
- Mean Citation Score: 613.561448
- Max Citation Score: 670.1730299999998
- Similarity Product: 608.9320592059491

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test