PATENT CLAIM ANALYSIS

Application Number: 16315800
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-06
Patent Classification: ["546", "255000"]

Abstract:
The present disclosure generally relates to compounds of formula (I), wherein R 2  is a phenyl or pyridinyl moiety, useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Claim (Index 7):
A compound selected from\n (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinolin-7-yl)benzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinolin-3-yl)benzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinolin-3-yl)benzyl)oxy)benzyl) piperidine-2-carboxylic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinolin-2-yl)benzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinolin-6-yl)benzyl)oxy)benzyl) amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinoxalin-2-yl)benzyl)oxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(isoquinolin-3-yl)-2-methylbenzyl)oxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(isoquinolin-7-yl)-2-methylbenzyl)oxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(isoquinolin-6-yl)-2-methylbenzyl)oxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((4-((3-(7-bromoquinoxalin-2-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl) methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((4-((3-(benzo[d]thiazol-6-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((4-((3-(benzo[d]oxazol-5-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((4-((3-(benzofuran-5-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (S)-2-((4-((3-(benzofuran-5-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)amino)-5-guanidinopentanoic acid; 2-((4-((3-(benzofuran-5-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy)benzyl) amino)-2-methylpropanoic acid; 2-((4-((3-(benzo[d]oxazol-6-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)amino)-2-methylpropanoic acid; (R)-2-((4-((3-(benzo[d]oxazol-6-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; 2-((4-((3-(benzofuran-6-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy)benzyl) amino)-2-methylpropanoic acid; (R)-2-((4-((3-(benzofuran-6-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (S)-1-(4-((3-(benzofuran-6-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)-2-methylpyrrolidine-2-carboxylic acid; (R)-2-((4-((3-(benzo[d]thiazol-5-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)amino)-3-hydroxy-2-methylpropanoic acid; 2-((4-((3-(benzo[d]thiazol-5-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)amino)-2-methylpropanoic acid; (S)-1-(4-((3-(benzo[d]thiazol-5-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy) benzyl)-2-methylpyrrolidine-2-carboxylic acid; (R)-2-((4-((3-(1H-benzo[d]imidazol-5-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl) methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(1-(2-(dimethylamino)ethyl)-1H-benzo[d]imidazol-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(1-(2-(dimethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid; 2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(1-(2-(dimethylamino)ethyl)-1H-benzo[d]imidazol-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-2-methylpropanoic acid; 2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(1-(2-(dimethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-2-methylbenzyl)oxy)benzyl)amino)-2-methylpropanoic acid; (R)-5-((4-chloro-2-formyl-5-((3-(2-(2-(3-hydroxypyrrolidin-1-yl)ethyl)benzo[d]oxazol-5-yl)-2-methylbenzyl)oxy) phenoxy)methyl)nicotinonitrile; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)benzo[d]oxazol-5-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)benzo[d]oxazol-5-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid; (S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(6-(3-((R)-3-hydroxypyrrolidin-1-yl) propoxy)pyridin-2-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid; (R)-5-((4-chloro-2-(hydroxymethyl)-5-((3-(6-(3-(3-hydroxypyrrolidin-1-yl)propoxy)pyridin-2-yl)-2-methylbenzyl)oxy)phenoxy)methyl)nicotinonitrile; (S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinoxalin-6-yl)benzyl)oxy)benzyl)piperidine-2-carboxylic acid; (R)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinoxalin-6-yl)benzyl)oxy)benzyl)piperidine-2-carboxylic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinoxalin-6-yl)benzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinoxalin-6-yl)benzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-3-(quinoxalin-6-yl)benzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(1-(3-((R)-3-hydroxypyrrolidin-1-yl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(1-(3-((R)-3-hydroxypyrrolidin-1-yl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(1-(3-((R)-3-hydroxypyrrolidin-1-yl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid; (S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(1-(3-((R)-3-hydroxypyrrolidin-1-yl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid; 5-((4-chloro-5-((3-(3-chloro-2-(3-(piperidin-1-yl)propoxy)pyridin-4-yl)-2-methylbenzyl)oxy)-2-(((1,3-dihydroxy-2-methylpropan-2-yl)amino)methyl)phenoxy)methyl)nicotinonitrile; (R)-5-((4-chloro-5-((3-(3-chloro-4-(3-(3-hydroxypyrrolidin-1-yl)propoxy)pyridin-2-yl)-2-methylbenzyl)oxy)-2-(((1,3-dihydroxy-2-methylpropan-2-yl)amino)methyl)phenoxy)methyl)nicotinonitrile; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(1-(4-((S)-3-hydroxypyrrolidin-1-yl)butyl)-3,5-dimethyl-1H-pyrazol-4-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; 5-((4-chloro-5-((3-(3-chloro-4-(3-hydroxypropoxy)pyridin-2-yl)-2-methylbenzyl)oxy)-2-(((1,3-dihydroxy-2-methylpropan-2-yl)amino)methyl)phenoxy)methyl)nicotinonitrile; (S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((5-(3-(3-((R)-3-hydroxypyrrolidin-1-yl)propoxy)-2-methylphenyl)-4-methylpyridin-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid; 5-((4-chloro-2-(((2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)amino)methyl)-5-((3-(4-(((2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)amino)methyl)-3,5-dimethyl-1H-pyrazol-1-yl)-2-methylbenzyl)oxy)phenoxy)methyl)nicotinonitrile; 5-((4-chloro-2-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-5-((3-(4-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-3,5-dimethyl-1H-pyrazol-1-yl)-2-methylbenzyl)oxy)phenoxy)methyl)nicotinonitrile; (R)-5-((4-chloro-2-(((1,3-dihydroxy-2-methylpropan-2-yl)amino)methyl)-5-((5-(3-(3-(3-hydroxypyrrolidin-1-yl)propoxy)-2-methylphenyl)-4-methylpyridin-3-yl)methoxy)phenoxy)methyl)nicotinonitrile; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(4-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-3,5-dimethyl-1H-pyrazol-1-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(4-formyl-3,5-dimethyl-1H-pyrazol-1-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid (S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((4-(3-(3-((R)-3-hydroxypyrrolidin-1-yl)propoxy)-2-methylphenyl)-3-methylpyridin-2-yl)methoxy)benzyl)piperidine-2-carboxylic acid; (S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((4-(3-(3-((R)-3-hydroxypyrrolidin-1-yl)propoxy)-2-methylphenyl)-3-methylpyridin-2-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; (R)-5-((4-chloro-2-(((1-hydroxy-2-(hydroxymethyl)butan-2-yl)amino)methyl)-5-((4-(3-(3-(3-hydroxypyrrolidin-1-yl)propoxy)-2-methylphenyl)-3-methylpyridin-2-yl)methoxy)phenoxy)methyl)nicotinonitrile; (S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-methyl-4-(2-methyl-3-(3-(piperidin-1-yl)propoxy)phenyl)pyridin-2-yl)methoxy)benzyl)piperidine-2-carboxylic acid; (S)-1-(4-((3-(benzo[d]oxazol-5-yl)-2-methylbenzyl)oxy)-5-chloro-2-((5-cyanopyridin-3-yl) methoxy)benzyl)piperidine-2-carboxylic acid; (S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-methyl-4-(2-methyl-3-(3-(piperidin-1-yl)propoxy)phenyl)pyridin-2-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid; and 5-((4-chloro-2-(((1-hydroxy-2-(hydroxymethyl)butan-2-yl)amino)methyl)-5-((3-methyl-4-(2-methyl-3-(3-(piperidin-1-yl)propoxy)phenyl)pyridin-2-yl)methoxy)phenoxy)methyl)nicotinonitrile; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 13.0
- Percentile: 99.0
- Lexical Diversity: 1.41509
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14681772', '15689115', '14915782', '15465218', '15563697']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8182412850453348
- 35 USC 102 Novelty (BERT): 0.5747584857184965
- Combined Prediction Score: 0.7938930051126509
- Mean Citation Score: 371.860384
- Max Citation Score: 468.0484
- Similarity Product: 436.2212116873026

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test