PATENT CLAIM ANALYSIS

Application Number: 16061369
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-02
Patent Classification: ["514", "081000"]

Abstract:
The present invention relates to spirocyclic quinolizine derivatives and pharmaceutically acceptable salts or prodrug thereof, compositions comprising at least one spirocyclic quinolizine derivative, and methods of using the spirocyclic quinolizine derivatives for treating or preventing HIV infection in a subject.

Claim (Index 1):
A compound having the formula (I): or a pharmaceutically acceptable salt or prodrug thereof, wherein:\n A is \u2014NHC(O)\u2014 or 5 or 6-membered monocyclic heteroaryl; \n B is 3 to 8-membered monocyclic heterocycloalkyl, which may be optionally substituted with one or more groups, each independently selected from R 6 ; \n X is C 1 -C 3  alkylene; \n Y is \u2014CH 2 \u2014, \u2014CH(R 6 )\u2014 or \u2014N(R 3 )\u2014; \n R is H or benzyl; \n each occurrence of R 1  is independently selected from H, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, \u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 , \u2014N(R 11 ) 2  and \u2014OR 7 , or both R 1  groups and the common carbon atom to which they are attached, join to form an exocyclic olefin group having the formula: \n R 2  represents up to 3 optional substitutents, each independently selected from halo, C 1 -C 6  alkyl, \u2014O\u2014(C 1 -C 6  alkyl) and C 1 -C 6  haloalkyl; R 3  is selected from H, C 1 -C 6  alkyl, \u2014SO 2 R 4 , \u2014C(O)R 4 , \u2014(C 1 -C 6  alkylene) m -C(O)N(R 5 ) 2 , \u2014(C 2 -C 4  alkylene)-O\u2014(C 1 -C 6  alkyl), \u2014(C 2 -C 4  alkylene)-S\u2014(C 1 -C 6  alkyl), \u2014(C 2 -C 4  alkylene)-SO 2 \u2014(C 1 -C 6  alkyl), \u2014(C 2 -C 4  alkylene)-N\u2014(C 1 -C 6  alkyl) 2 , \u2014(C 1 -C 6  alkylene)-Z\u2014(C 1 -C 3  alkylene) m -R 11 , C 3 -C 7  cycloalkyl, phenyl, 4 to 8-membered monocyclic heterocycloalkyl, 6-membered monocyclic heteroaryl and 8 to 10-membered bicyclic heteroaryl; each occurrence of R 4  is independently selected from H, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 7  cycloalkyl, phenyl, 3 to 8-membered monocyclic heterocycloalkyl, 6-membered monocyclic heteroaryl and 8 to 10-membered bicyclic heteroaryl, wherein said C 3 -C 7  cycloalkyl group, said phenyl group, said 3 to 8-membered monocyclic heteroaryl group, said 6-membered monocyclic heteroaryl group and said 8 to 10-membered bicyclic heteroaryl group may be optionally substituted with one or more groups, each independently selected from R 6 ; each occurrence of R 5  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, \u2014(C 1 -C 6  alkylene)-N(R 7 ) 2 , C 1 -C 6  haloalkyl, \u2014C(O)O(C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 , \u2014(C 1 -C 6  alkylene) m -R 8  and \u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkyl); each occurrence of R 6  is independently selected from halo, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 , \u2014N(R 20 ) 2 , 3 to 8-membered monocyclic heterocycloalkyl, 6 to 10-membered bicyclic heterocycloalkyl, \u2014O\u2014(C 1 -C 6  alkyl), \u2014O\u2014(C 6 -C 10  aryl), \u2014O\u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkyl), \u2014O\u2014(C 1 -C 6  haloalkyl), \u2014O\u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkyl), \u2014S(O) 2 (C 1 -C 6  alkyl), \u2014NHS(O) 2 \u2014(C 1 -C 6  alkyl), \u2014S(O) 2 NH\u2014(C 1 -C 6  alkyl), \u2014OC(O)\u2014(C 1 -C 6  haloalkyl), \u2014(C 1 -C 6  alkylene) m -C(O)O\u2014(C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkylene) m -C(O)\u2014(C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkylene) m -C(O)N(R 7 ) 2 , C 1 -C 6  hydroxyalkyl, \u2014P(O)(OR 9 ) 2  and \u2014CN; each occurrence of R 7  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, C 1 -C 6  haloalkyl, \u2014C(O)O(C 1 -C 6  alkyl), \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 , \u2014(C 1 -C 6  alkylene) m -R 8  and \u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 6  alkyl); each occurrence of R 8  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, 5 or 6-membered monocyclic heteroaryl and 3 to 8-membered monocyclic heterocycloalkyl; each occurrence of R 9  is independently selected from H, C 1 -C 6  alkyl and \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 ; R 10  is selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl and \u2014(C 1 -C 4  alkylene)-O\u2014(C 1 -C 6  alkyl); each occurrence of R 11  is independently selected from \u2014P(O)(\u2014OR 18 ) 2 , each occurrence of R 12  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, phenyl or benzyl, wherein said C 1 -C 6  alkyl may be optionally substituted with a group selected from halo, \u2014OR 16 , \u2014SR 16 , guanidino, \u2014N(R 16 ) 2 , \u2014C(O)OR 16 , \u2014C(O)N(R 16 ) 2 , \u2014NHC(O)R 16 , 5- or 6-membered monocyclic heteroaryl and 9- or 10-membered bicyclic heteroaryl, and wherein said phenyl group and said benzyl group may be optionally substituted with up to 2 groups, each independently selected from C 1 -C 6  alkyl, halo and \u2014OR 16 ; each occurrence of R 13  is independently selected from H, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, phenyl or benzyl, wherein said C 1 -C 6  alkyl may be optionally substituted with a group selected from halo, \u2014OR 16 , \u2014SR 16 , guanidino, \u2014N(R 16 ) 2 , \u2014C(O)OR 16 , \u2014C(O)N(R 16 ) 2 , \u2014NHC(O)R 16 , 5- or 6-membered monocyclic heteroaryl and 9- or 10-membered bicyclic heteroaryl, and wherein said phenyl group and said benzyl group may be optionally substituted with up to 2 groups, each independently selected from C 1 -C 6  alkyl, halo and \u2014OR 16 ; each occurrence of R 14  is independently selected from H, C 1 -C 20  alkyl, C 2 -C 20  alkenyl, \u2014(C 1 -C 3  alkylene) m -(C 3 -C 7  cycloalkyl), \u2014(C 1 -C 3  alkylene) m -(C 6 -C 10  aryl) or \u2014(C 1 -C 3  alkylene) m -adamantyl, wherein said C 1 -C 20  alkyl group, said C 2 -C 20  alkenyl group, said C 6 -C 10  aryl group and said adamantyl group may be optionally substituted with up to three groups, each independently selected from halo, \u2014OR 16 , \u2014C(O)OR 16 , CN, NO 2 , C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, C 3 -C 7  cycloalkyl, C 6 -C 10  aryl, 5- or 6-membered monocyclic heteroaryl, 9- or 10-membered bicyclic heteroaryl, \u2014N(R 16 ) 2 , \u2014C(O)N(R 16 ) 2 \u2014SR 16 , \u2014S(O)R 16 , \u2014S(O) 2 R 16 , \u2014S(O) 2 N(R 16 ) 2 , \u2014NHC(O)R 16 , \u2014NHC(O)OR 16  and \u2014NHC(O)N(R 16 ) 2 ; R 15  is selected from H, C 6 -C 10  aryl, 5- or 6-membered monocyclic heteroaryl and 9- or 10-membered bicyclic heteroaryl, wherein said C 6 -C 10  aryl group, said 5- or 6-membered monocyclic heteroaryl group and said 9- or 10-membered bicyclic heteroaryl group may be optionally substituted with R 17 ; each occurrence of R 16  is independently selected from H, C 1 -C 10  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, \u2014(C 1 -C 3  alkylene) m -(C 3 -C 7  cycloalkyl), \u2014(C 1 -C 3  alkylene) m -(C 6 -C 10  aryl), \u2014(C 1 -C 3  alkylene) m -(4 to 7-membered heterocycloalkyl), \u2014(C 1 -C 3  alkylene) m -(5- or 6-membered monocyclic heteroaryl) and \u2014(C 1 -C 3  alkylene) m -(9- or 10-membered bicyclic heteroaryl), wherein said C 3 -C 7  cycloalkyl group, said C 6 -C 10  aryl group, said 4 to 7-membered heterocycloalkyl group, said -5- or 6-membered monocyclic heteroaryl group or said 9- or 10-membered bicyclic heteroaryl group may be optionally substituted with R 17 ; R 17  represents from one to five substituent groups, each independently selected from C 1 -C 6  alkyl, halo, \u2014OR 19 , \u2014SR 19 , C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, \u2014O\u2014(C 1 -C 6  haloalkyl), \u2014CN, \u2014NO 2 , \u2014N(R 19 ) 2 , \u2014C(O)OR 19 , \u2014C(O)N(R 19 ) 2  and \u2014NHC(O)R 19 ; each occurrence of R 18  is independently selected from H, C 1 -C 6  alkyl, C 6 -C 10  aryl, \u2014(C 1 -C 6  alkylene)-O\u2014(C 1 -C 20  alkyl), \u2014(C 1 -C 6  alkylene)-O\u2014C(O)\u2014R 16 , and \u2014(C 1 -C 6  alkylene)-O\u2014C(O)\u2014O\u2014R 16 ; each occurrence of R 19  is independently selected from H, C 1 -C 10  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  hydroxyalkyl, \u2014(C 1 -C 3  alkylene) m -(C 3 -C 7  cycloalkyl), \u2014(C 1 -C 3  alkylene) m -(C 6 -C 10  aryl), \u2014(C 1 -C 3  alkylene) m -(4 to 7-membered heterocycloalkyl), \u2014(C 1 -C 3  alkylene) m -(5- or 6-membered monocyclic heteroaryl) and \u2014(C 1 -C 3  alkylene) m -(9- or 10-membered bicyclic heteroaryl); each occurrence of R 20  is independently selected from H, C 1 -C 6  alkyl and \u2014(C 1 -C 6  alkylene) m -Z\u2014(C 1 -C 3  alkylene) m -R 11 ; each occurrence of R 21  is independently selected from H and C 1 -C 6  alkyl; each occurrence of Z is independently selected from a bond, \u2014O\u2014 or \u2014N(R 9 )\u2014; each occurrence of m is independently 0 or 1; and n is 1 or 2.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 94.0
- Lexical Diversity: 1.22857
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15560896', '15775871', '15575433', '15775966', '14652580']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8098931884613071
- 35 USC 102 Novelty (BERT): 0.577497293481889
- Combined Prediction Score: 0.7866535989633653
- Mean Citation Score: 442.889044
- Max Citation Score: 454.46243
- Similarity Product: 420.7026204115594

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test