PATENT CLAIM ANALYSIS

Application Number: 16073809
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-02
Patent Classification: ["544", "262000"]

Abstract:
The present invention relates to a process for the preparation of 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib of Formula (I). The present invention further relates to a process for the preparation highly pure 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib(I)

Claim (Index 7):
A process for the preparation of Ibrutinib (1) according to  claim 6 , wherein the reaction is carried out in presence of a solvent selected from solvent selected from alcohols, such as C2-C6 alcohols like ethanol, 1-propanol, 2-propanol (isopropyl alcohol), 1-butanol, 2-butanol, t-butyl alcohol; or nitriles, such as acetonitrile or propionitrile; amides such as N,N-dimethylformamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone; sulfoxides such as dimethylsulfoxide; halogenated hydrocarbons such as dichloromethane; aromatic hydrocarbons such as toluene, xylene; esters such as ethyl acetate, n-propyl acetate, n-butyl acetate, isopropyl acetate, isobutyl acetate, t-butyl acetate; ethers such as diethyl ether, diisopropyl ether, methyl t-butyl ether, tetrahydrofuran, 1,4-dioxane, 2-methoxyethanol, anisole; ketones such as acetone, ethyl methyl ketone, diethyl ketone, methyl isobutyl ketone; organic solvents such as formamide, dimethyl formamide, N-methyl-2-pyrrolidone, N-methyl formamide, N-vinyl acetamide, N-vinyl pyrrolidone, 2-pyrrolidone, n-hexane, n-heptane, cyclohexane, cycloheptane; hetero aromatic solvents such as pyridine, dimethyl amino pyridine; water or mixtures thereof;

Metadata:
- Claim Count in Document: 4.0
- Percentile: 95.0
- Lexical Diversity: 2.33333
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['16074505', '13859569', '14418484', '13908949', '14374788']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7428700948964121
- 35 USC 102 Novelty (BERT): 0.5608115585121106
- Combined Prediction Score: 0.724664241257982
- Mean Citation Score: 379.26753
- Max Citation Score: 448.23163
- Similarity Product: 322.01051204330804

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test