PATENT CLAIM ANALYSIS

Application Number: 16168242
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-07
Patent Classification: ["514", "017500"]

Abstract:
The disclosure relates, at least in part, to methods of treating autism in a patient in need thereof by administering an effective amount of a disclosed compound, e.g., a NMDA receptor glycine site partial agonist.

Claim (Index 12):
A method of treating attention deficit disorder, ADHD, schizophrenia, anxiety, amelioration of opiate, nicotine and/or ethanol addiction, traumatic brain injury, spinal cord injury, post-traumatic stress syndrome and/or Huntington's chorea, in a patient in need thereof, comprising administering to the patient:\n a pharmaceutically effective amount of GLYX-13: \u2003or pharmaceutically acceptable salt thereof,\n or \n a pharmaceutically effective amount of a compound represented by Formula I: and pharmaceutically acceptable salts, stereoisomers, and N-oxides thereof; wherein T is, independently for each occurrence, CR 4 R 4 \u2032, and n is 0, 1, 2 or 3; A is optionally present and is selected from phenyl or pyridine, wherein A is optionally substituted by one or more substituents selected from R a ; R 1  is selected from the group consisting of H, hydroxyl, \u2014S(O) 2 \u2014C 1-4 alkyl; \u2014SO 2 , C 1-4 alkyl, C 2 -C 4 alkenyl, phenyl, R 7 , or \u2003wherein C 1-4 alkyl, C 2-4 alkenyl, or phenyl is optionally substituted by one or more substituents selected from R a ; X is CH or N; R 3  and R 3 \u2032 are independently selected from the group consisting of H, halogen, hydroxyl, phenyl, amido, amine, or C 2-4 alkenyl, wherein C 1-4 alkyl, C 2-4 alkenyl and phenyl are optionally substituted by one or more substituents selected from R a ; R 4  and R 4 \u2032 are independently selected from the group consisting of H, halogen, hydroxyl, phenyl, amido, amine, C 1-4 alkoxy or C 2-4 alkenyl, wherein C 1-4 alkyl, C 2-4 alkenyl, C 1-4 alkoxy, and phenyl are optionally substituted by one or more substituents selected from R a ; R 2  is selected from the group consisting of H, R 7 , \u2014S(O) 2 , S(O) 2 \u2014C 1 -C 4 alkyl, C 1-4 alkyl, hydroxyl, or phenyl wherein C 1-4 alkyl, C 2-4  alkenyl and phenyl are optionally substituted by one or more substituents selected from R a ; R 5  and R 5 \u2032 are each independently selected from group consisting of H, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 2-4 alkenyl, cyano, amino, phenyl, and hydroxyl, wherein C 1-4 alkyl, C 2-4 alkenyl and phenyl are optionally substituted by one or more substituents selected from R a ; R 7  is selected from group consisting of \u2014C(O)\u2014R 9 , \u2014C(O)\u2014O\u2014R 9 , or \u2014C(O)\u2014NR d \u2014R 9 , R 9  is selected from the group consisting of H, C 1-4 alkyl, phenyl, or heterocyclic, wherein C 1-4 alkyl, phenyl or heterocyclic is optionally substituted by 1, 2 or 3 substituents selected from R b  R 8  is selected from group consisting of H, \u2014C(O)\u2014C 1-4 alkyl or C(O)\u2014O\u2014C 1-4  alkyl, wherein C 1-4 alkyl is optionally substituted by 1, 2 or 3 substituents selected from R a ; R a  is selected, independently for each occurrence, from carboxy, hydroxyl, halogen, amino, phenyl, C 1-4 alkyl, and C 1-4 alkoxy; R b  is selected, independently for each occurrence, from the group consisting of carboxy, hydroxyl, halogen, amino, phenyl, C 1-4 alkyl, C 1-4 alkoxy, and \u2014NH\u2014R e ; R c  is selected, independently for each occurrence from the group consisting of: \u2014C(O)\u2014O\u2014C 1-4 alkyl; and \u2014C(O)\u2014C 1-4 alkyl; and R d  is selected, independently for each occurrence, H and C 1-4 alkyl; and pharmaceutically acceptable salts, N-oxides or stereoisomers thereof.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 97.0
- Lexical Diversity: 1.25
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14050641', '14580803', '15328341', '14764419', '15653738']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7690837631804125
- 35 USC 102 Novelty (BERT): 0.5358416310778374
- Combined Prediction Score: 0.745759549970155
- Mean Citation Score: 318.149788
- Max Citation Score: 376.27896
- Similarity Product: 323.17718853352545

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test