PATENT CLAIM ANALYSIS

Application Number: 16316714
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-09
Patent Classification: ["548", "364100"]

Abstract:
The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Claim (Index 19):
A compound as defined in  claim 1  of the formula or a pharmaceutically acceptable salt thereof, wherein each R 4  is independently hydrogen, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, \u2014NO 2 , or \u2014CN; each R Z  is independently halogen, \u2014CN, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  alkenyl, C 3 -C 6  cycloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  alkanol, \u2014COO C 1 -C 6  alkyl, \u2014CONR z1 R z2 , \u2014NHC(O) C 1 -C 6  haloalkyl, \u2014NHC(O) C 1 -C 6  alkyl, or \u2014NH C 1 -C 6  alkyl; each R z1  and R z2  is independently hydrogen, C 1 -C 6  alkyl or C 3 -C 6  cycloalkyl; R 1  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkenyl, C 1 -C 6  alkanol, C 1 -C 6  haloalkyl, C 1 -C 6  alkyloxy, CONR 1a R 1b , \u2014NHC(O) C 1 -C 6  alkyl, \u2014COOH or \u2014COO C 1 -C 6  alkyl; each R 1a  and R 1b  is independently hydrogen, C 1 -C 6  alkyl or C 3 -C 6  cycloalkyl R 2  is hydrogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkyloxy or C 3 -C 8  cycloalkyl; or R 1  and R 2  combined with the atoms to which they are attached form a five- to eight-membered ring.

Metadata:
- Claim Count in Document: 22.0
- Percentile: 99.0
- Lexical Diversity: 1.43333
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14977709', '14072563', '14819541', '14339123', '14820611']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7638381370791878
- 35 USC 102 Novelty (BERT): 0.5024004787823189
- Combined Prediction Score: 0.7376943712495009
- Mean Citation Score: 280.301294
- Max Citation Score: 286.54965
- Similarity Product: 239.525847220087

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test