PATENT CLAIM ANALYSIS

Application Number: 16260744
Application Type: Utility
Filing Date: 2019-01
Publication Date: 2019-08
Patent Classification: ["544", "265000"]

Abstract:
The present invention relates to compounds of formula (I), wherein R 1 , R 2  and R 3  are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Claim (Index 13):
A compound selected from:\n 6-Amino-9-benzyl-N-methyl-8-oxo-N-propyl-2-(propylsulfonimidoyl)purine-7-carb oxamide; 6-Amino-9-benzyl-N-(2-methoxyethyl)-N-methyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carboxamide; 6-Amino-9-benzyl-N-ethyl-8-oxo-N-propyl-2-(propyl sulfonimidoyl)purine-7-carb oxamide; 6-Amino-9-benzyl-7-[4-(1-piperidyl)piperidine-1-carbonyl]-2-(propylsulfonimidoyl)purin-8-one; 6-Amino-9-benzyl-N-ethyl-N-(2-methoxyethyl)-8-oxo-2-(propyl sulfonimidoyl)purine-7-carb oxamide; 6-Amino-9-benzyl-N-butyl-N-ethyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carboxamide; 6-Amino-9-benzyl-N-(2-methoxyethyl)-8-oxo-N-propyl-2-(propylsulfonimidoyl)purine-7-carboxamide; 6-Amino-9-benzyl-N,N-bis(2-methoxyethyl)-8-oxo-2-(propyl sulfonimidoyl)purine-7-carb oxamide; 6-Amino-7-(azetidine-1-carbonyl)-9-benzyl-2-(propylsulfonimidoyl)purin-8-one; 6-Amino-9-benzyl-N-isopropyl-N-methyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carb oxamide; 6-Amino-9-benzyl-7-(4-methylpiperazine-1-carbonyl)-2-(propyl sulfonimidoyl)purin-8-one; 6-Amino-9-benzyl-N-(3-methoxypropyl)-N-methyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carboxamide; 6-Amino-9-benzyl-N-isobutyl-N-methyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carb oxamide; Ethyl 2-[[6-amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]acetate; Ethyl 3-[[6-amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]propanoate; tert-Butyl 3-[[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]-methyl-amino]propanoate; Ethyl (2S)-2-[[6-amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]propanoate; tert-Butyl (2S)-2-[[6-amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]-4-methyl-pentanoate; Isopropyl (2S)-2-[[6-amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]-4-methyl-pentanoate; Ethyl (2S)-2-[[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]-methyl-amino]-3-methyl-butanoate; Ethyl (2S)-2-[[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]-methyl-amino]-4-methyl-pentanoate; Ethyl (2S)-2-[[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]-methyl-amino]-3-phenyl-propanoate; Isopropyl (2S)-2-[[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]-methyl-amino]-3-phenyl-propanoate; tert-Butyl (2S)-2-[[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]-methyl-amino]-3-phenyl-propanoate; N-[2-[Acetyl(methyl)amino]ethyl]-6-amino-9-benzyl-N-methyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carboxamide; Methyl N-[2-[[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]-methyl-amino]ethyl]-N-methyl-carbamate; tert-Butyl N-[2-[[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]-methyl-amino]ethyl]-N-methyl-carbamate; Ethyl N-[2-[[6-amino-9-benzyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carbonyl]-methyl-amino]ethyl]-N-methyl-carbamate; 2-[[6-Amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]ethyl N-butyl-N-methyl-carbamate; 2-[[6-Amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]ethyl pyrrolidine-1-carboxylate; 2-[[6-Amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]ethyl N-methyl-N-propyl-carbamate; 2-[[6-Amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]ethyl N,N-diethylcarbamate; 2-[[6-Amino-9-benzyl-8-oxo-2-(propyl sulfonimidoyl)purine-7-carbonyl]-methyl-amino]ethyl ethyl carbonate; 6-Amino-N-butyl-9-[(4-chlorophenyl)methyl]-N-methyl-8-oxo-2-[S(S)-propylsulfonimidoyl]purine-7-carboxamide; 6-amino-N-butyl-9-[(4-chlorophenyl)methyl]-N-methyl-8-oxo-2-[S(S)-propylsulfonimidoyl]purine-7-carboxamide; 6-Amino-9-[(4-chlorophenyl)methyl]-N-ethyl-N-methyl-8-oxo-2-(propylsulfonimidoyl)purine-7-carboxamide; 6-Amino-N-methyl-8-oxo-N-propyl-2[S(S)-propylsulfonimidoyl]-9-(p-tolylmethyl)purine-7-carboxamide; 6-Amino-N-methyl-8-oxo-N-propyl-2[S(R)-propylsulfonimidoyl]-9-(p-tolylmethyl)purine-7-carboxamide; 6-Amino-2-[S(S)-propylsulfonimidoyl]-9-(p-tolylmethyl)-7-(pyrrolidine-1-carbonyl)purin-8-one; 6-Amino-2-[S(R)-propylsulfonimidoyl]-9-(p-tolylmethyl)-7-(pyrrolidine-1-carbonyl)purin-8-one; 6-Amino-N-(2-methoxyethyl)-N-methyl-8-oxo-2-[S(S)-propylsulfonimidoyl]-9-(p-tolylmethyl)purine-7-carboxamide; 6-Amino-N-(2-methoxyethyl)-N-methyl-8-oxo-2-[S(R)-propylsulfonimidoyl]-9-(p-tolylmethyl)purine-7-carboxamide; 6-Amino-N-ethyl-N-methyl-8-oxo-2-(propyl sulfonimidoyl)-9-(p-tolylmethyl)purine-7-carb oxamide; 6-Amino-N-butyl-N-methyl-8-oxo-2-(propylsulfonimidoyl)-9-(p-tolylmethyl)purine-7-carb oxamide; 6-Amino-9-[(4-chlorophenyl)methyl]-2-[S(R)-ethylsulfonimidoyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide; 6-Amino-9-[(4-chlorophenyl)methyl]-2-[S(S)-ethyl sulfonimidoyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide; 6-Amino-9-[(4-chlorophenyl)methyl]-N-ethyl-2[S(S)-ethylsulfonimidoyl]-N-methyl-8-oxo-purine-7-carb oxamide; 6-Amino-9-[(4-chlorophenyl)methyl]-N-ethyl-2-[S(R)-ethyl sulfonimidoyl]-N-methyl-8-oxo-purine-7-carboxamide; 6-Amino-2-[S(S)-ethyl sulfonimidoyl]-N-methyl-8-oxo-N-propyl-9-(p-tolylmethyl)purine-7-carboxamide; 6-Amino-2-[S(R)-ethylsulfonimidoyl]-N-methyl-8-oxo-N-propyl-9-(p-tolylmethyl)purine-7-carboxamide; 6-Amino-N-ethyl-2[S(S)-ethylsulfonimidoyl]-N-methyl-8-oxo-9-(p-tolylmethyl)purine-7-carb oxamide; 6-Amino-N-ethyl-2-[S(R)-ethyl sulfonimidoyl]-N-methyl-8-oxo-9-(p-tolylmethyl)purine-7-carboxamide; 6-Amino-2-[S(S)ethylsulfonimidoyl]-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide; 6-Amino-2-[S(R)ethylsulfonimidoyl]-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide; 6-Amino-N-ethyl-2-(ethylsulfonimidoyl)-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-purine-7-carb oxamide; 6-Amino-N-ethyl-2-[S(S)-(ethylsulfonimidoyl)]-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-purine-7-carboxamide; 6-Amino-N-ethyl-2-[S(R)-(ethylsulfonimidoyl)]-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-purine-7-carboxamide; 6-Amino-9-[(4-bromophenyl)methyl]-2-(ethylsulfonimidoyl)-N-methyl-8-oxo-N-propyl-purine-7-carb oxamide; 6-Amino-2-[S(R)-ethyl sulfonimidoyl]-9-[(4-bromophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide; 6-Amino-2-[S(S)-ethylsulfonimidoyl]-9-[(4-bromophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide; 6-Amino-9-[(4-bromophenyl)methyl]-N-ethyl-2-(ethylsulfonimidoyl)-N-methyl-8-oxo-purine-7-carb oxamide; 6-Amino-9-[(4-bromophenyl)methyl]-N-ethyl-2-[S(S)-(ethylsulfonimidoyl)]-N-methyl-8-oxo-purine-7-carboxamide; and 6-Amino-9-[(4-bromophenyl)methyl]-N-ethyl-2-[S(R)-(ethyl sulfonimidoyl)]-N-methyl-8-oxo-purine-7-carboxamide; or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 99.0
- Lexical Diversity: 1.37838
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15689136', '15148309', '15621080', '14958619', '13395429']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7766110724337612
- 35 USC 102 Novelty (BERT): 0.6852809087286299
- Combined Prediction Score: 0.7674780560632481
- Mean Citation Score: 438.6716619999999
- Max Citation Score: 698.61176
- Similarity Product: 675.0982408306073

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test