PATENT CLAIM ANALYSIS

Application Number: 16019449
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["530", "337000"]

Abstract:
Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing and using the formulations, substrates, and arrays including one-step coupling, e.g., for synthesis of peptides in a C→N orientation are disclosed. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

Claim (Index 25):
A method of attaching a coupling molecule to a substrate, comprising:\n obtaining a substrate comprising a plurality of amine groups for linking to a coupling molecule; contacting said substrate with a carboxylic acid activating formulation comprising: a carboxylic acid activating compound, wherein said compound is 1-(3-(diethylamino)-propyl)-4-(2-methoxyphenyl)-1,4-dihydro-5H-tetrazole-5-thione, a coupling molecule comprising an amino acid with an Fmoc protecting group attached to an amine group, and a solvent; selectively exposing said photoactive coupling formulation to light, thereby activating a carboxylic group of said coupling molecule at a selectively exposed area; coupling the activated carboxylic group of said coupling molecule to at least one of said plurality of amine groups at said selectively exposed area, wherein said coupling is performed multiple times at different selectively exposed areas on said substrate and wherein said coupling step has a coupling efficiency of at least 90%; and optionally repeating said method to produce a desired polymer at said at least one carboxylic acid group.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 94.0
- Lexical Diversity: 1.775
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15120452', '14442389', '14454554', '14941404', '14449943']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6258895018591475
- 35 USC 102 Novelty (BERT): 0.5593759390212768
- Combined Prediction Score: 0.6192381455753605
- Mean Citation Score: 295.671822
- Max Citation Score: 423.08432
- Similarity Product: 366.947450257473

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test