PATENT CLAIM ANALYSIS

Application Number: 15876810
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "253040"]

Abstract:
The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R 1 -R 4  are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X 3  or P2X 2/3  receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

Claim (Index 7):
The method according to  claim 1 , wherein R 5  and R 6  are joined to form an optionally substituted heteroaryl or an optionally substituted 5 or 6-membered heterocyclic ring, optionally substituted pyrrolidine, piperazine or piperidine, an optionally substituted imidazole, pyrazole, tetrazole, or triazole, pyrrolidine optionally substituted with one or more C 1  to C 6  alkyl or C 1  to C 6  alkoxy, imidazole substituted with one or more C 1  to C 6  alkyl, a pyrazole substituted with one or more C 1  to C 6  alkyl, tetrazole substituted with one or more C 3  to C 6  cycloalkyl, C 1  to C 6  alkyl, C 1  to C 6  hydroxyalkyl, C 1  to C 6  alkyl containing 1-3 fluorine atoms, and C 3  to C 6  cycloalkyl-C 1  to C 6  alkyl, triazole substituted with one or more C 3  to C 6  cycloalkyl, C 1  to C 6  alkyl containing 1-3 fluorine atoms, and C 1  to C 6  alkyl, a piperidine substituted with one or more C 1  to C 6  alkoxy, halogen, C 1  to C 6  alkyl containing 1-3 fluorine atoms, C 1  to C 6  alkyl, or CONH 2 , a piperazine substituted with one CONH 2 , form 3-methoxy-pyrrolidine, 3-methyl-3-methoxy-pyrrolidine, 2,5-dimethyl-imidazole, 5-ethyl-pyrazole, 5-propyl-tetrazole, 5-cyclopropyl-tetrazole, 5-propyl-tetrazole, 5-isopropyl-tetrazole, 5-ethyl-tetrazole, 5-cyclobutyl-tetrazole, 5-cyclopropylmethyl-tetrazole, 5-methyl-tetrazole, 5-hydroxymethyl-tetrazole, 5-difluoromethyl-tetrazole, 5-(2,2,2-trifluoroethyl)-tetrazole, 5-(1,1-difluoroethyl)-tetrazole, 5-cyclopropyl-triazole, 5-difluoromethyl-triazole, 5-trifluoromethyl-triazole, 5-methyl-triazole, 5-isopropyl-triazole, 5-propyl-triazole, 5-ethyl-triazole, 5-tert-butyl-triazole, 5-cyclobutyl-triazole, 5-(1,1-difluoroethyl)-triazole, 5-(2,2,2-trifluoroethyl)-triazole, 3,5-dimethyl-1,2,4-triazole, 4-methyl-piperidine, 4,4-dimethyl-piperidine, 4,4-difluoro-piperidine, 4-methyl-4-carboxamido-piperidine, 4-fluoro-piperidine, 4-trifluoromethyl-piperidine, 4-fluoromethyl-piperidine, 4-methyl-4-methoxy-piperidine, 4-methoxy-piperidine, or 3-methoxy-piperidine, or 4-carboxamido-piperazine.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 86.0
- Lexical Diversity: 2.10909
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15184800', '15105526', '12337683', '12142846', '12868815']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8218879950665825
- 35 USC 102 Novelty (BERT): 0.653698782014053
- Combined Prediction Score: 0.8050690737613295
- Mean Citation Score: 464.4129620000001
- Max Citation Score: 650.9054
- Similarity Product: 601.4041714599608

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test