PATENT CLAIM ANALYSIS

Application Number: 15973861
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["546", "184000"]

Abstract:
A process for preparing a diazabicyclooctane compound represented by the following formula (I): wherein A represents RcO—; B represents NH or NC 1-6  alkyl; C represents a benzyl group; Rc represents a C 1-6  alkyl group; A is substituted with one substituent Fn1, wherein Fn1 represents an azetidine group; the process including: (a) silylating the compound represented by the following formula (IV-c): wherein in the formula (IV-c), OBn represents benzyloxy, and (b) carrying out an intramolecular urea formation reaction.

Claim (Index 3):
A process for preparing (2S,5R)\u2014N-(2-aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide represented by the following formula (III-059): which comprises: among the compounds represented by the following formulae (IV-a2), (IV-a3) and (IV-a4): wherein in the formula (IV-a2), (IV-a3) or (IV-a4), TFA represents trifluoroacetyl, Boc represents tert-butoxycarbonyl, Teoc represents 2-trimethylsilylethoxycarbonyl, and OBn represents benzyloxy, subjecting to coupling the compound represented by the formula (IV-a2) or (IV-a4) with tert-butyl 2-(aminooxy)ethylcarbamate in the presence of an active ester, an active amide or a dehydration condensing agent, or subjecting to coupling the compound represented by the formula (IV-a3) with benzyl 2-(aminooxy)ethylcarbamate in the presence of an active ester, an active amide or a dehydration condensing agent, to prepare a compound represented by the following formula (IV-b2-Boc-059), (IV-b3-Cbz-059) or (IV-b4-Boc-059): wherein in the formula (IV-b2-Boc-059), (IV-b3-Cbz-059) or (IV-b4-Boc-059), TFA represents trifluoroacetyl, Boc represents tert-butoxycarbonyl, Cbz represents benzyloxycarbonyl, Teoc represents 2-trimethylsilylethoxycarbonyl, and OBn represents benzyloxy, deprotecting the trifluoroacetyl group of the compound represented by the formula (IV-b2-Boc-059) by a treatment with a base to prepare a compound represented by the following formula (IV-c-Boc-059): wherein in the formula (IV-c-Boc-059) or (IV-c-Cbz-059), Boc represents tert-butoxycarbonyl, Cbz represents benzyloxycarbonyl, and OBn represents a benzyloxy, removing the tert-butoxycarbonyl of the compound represented by the formula (IV-b3-Cbz-059) by an acid treatment to prepare a compound represented by the formula (IV-c-Cbz-059), or removing the 2-trimethylsilylethoxycarbonyl of the compound represented by the formula (IV-b4-Boc-059) by a fluoride to prepare a compound represented by the formula (IV-c-Boc-059), then, after silylating the compound (IV-c-Boc-059) or (IV-c-Cbz-059), carrying out an intramolecular urea formation reaction to prepare a compound represented by the following formula (IIa-Boc-059) or (IIa-Cbz-059): wherein in the above formula (IIa-Boc-059) or (IIa-Cbz-059), Boc represents tert-butoxycarbonyl, Cbz represents benzyloxycarbonyl, and OBn represents benzyloxy, removing the benzyl of the benzyloxy at the 6-position of the compound represented by the formula (IIa-Boc-059) in the presence of a hydrogenolysis catalyst under a hydrogen atmosphere, or removing the benzyl of the benzyloxy at the 6-position of the compound represented by the formula (IIa-Cbz-059) in the presence of a hydrogenolysis catalyst under a hydrogen atmosphere, and simultaneously carrying out a tert-butoxycarbonylation in the presence of di-tert-butoxydicarbonate to prepare a compound represented by the following formula (IIb-Boc-059): wherein in the formula (IIb-Boc-059), Boc represents tert-butoxycarbonyl, sulfating the hydroxyl group at the 6-position of the formula (IIb-Buc-059) to prepare a compound represented by the following formula (III-Boc-059): wherein in the formula (III-Boc-059), Boc represents tert-butoxycarbonyl, and M represents H, pyridinium, sodium or tetrabutylammonium, and deprotecting the tert-butoxycarbonyl group by an acid treatment.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 93.0
- Lexical Diversity: 1.87037
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14872988', '14404288', '15023976', '15027956', '15613620']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8344786226720867
- 35 USC 102 Novelty (BERT): 0.6135644189929749
- Combined Prediction Score: 0.8123872023041755
- Mean Citation Score: 524.63413
- Max Citation Score: 619.3584
- Similarity Product: 471.8202094656944

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test