PATENT CLAIM ANALYSIS

Application Number: 16129696
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["514", "04400A"]

Abstract:
Disclosed herein are molecules and pharmaceutical compositions that induce an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that induces an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion.

Claim (Index 1):
A method of inducing exon skipping in a targeted pre-mRNA transcript of DMD gene, comprising:\n a) contacting a target cell with a polynucleic acid molecule conjugate, wherein the polynucleic acid molecule conjugate comprises an antibody or its binding fragments thereof, and a targeted pre-mRNA splice modulating polynucleic acid moiety conjugated to the antibody or its binding fragments thereof; b) hybridizing the targeted pre-mRNA splice modulating polynucleic acid moiety to a target region of the DMD pre-mRNA transcript to induce exon skipping in the targeted pre-mRNA transcript; and c) translating a mRNA transcript produced from the processed pre-mRNA transcript of step b) in the target cell to generate a truncated DMD protein.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 97.0
- Lexical Diversity: 1.94872
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16129694', '16128440', '15288415', '15619984', '12605276']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7256928433839333
- 35 USC 102 Novelty (BERT): 0.5213142899576005
- Combined Prediction Score: 0.7052549880413
- Mean Citation Score: 296.0966400000001
- Max Citation Score: 325.94104
- Similarity Product: 238.6797214164734

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test