PATENT CLAIM ANALYSIS

Application Number: 15762488
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "186000"]

Abstract:
The present invention relates to highly efficient Nrf2 activators-CO-releasing molecules of formula (I) and (II) capable of increasing HO-1 protein expression and simultaneously releasing CO, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory or cardiovascular diseases, wherein CORM represents a carbonyl metal complex chosen from among: Mn(CO) 5 , formula (III), (IV), (V), (VI), (VII), (VIII) and (IX).

Claim (Index 3):
A compound of following general formula (II): wherein: A represents:\n a single bond, or \n -Q-Z\u2014, where:\n Q represents O, S or NR 6 , where R 6  represents H, (C 1 -C 6 )alkyl, aryl, heteroaryl, (C 1 -C 6 )alkyl-aryl, (C 1 -C 6 )alkyl-heteroaryl, (C 1 -C 6 )alkyl-(C 3 -C 8 )heterocyclyl, \u2014(C 3 -C 14 )cycloalkyl, or R 6  and Z are connected to form a (C 3 -C 8 )heterocyclyl, \n \n Z represents \u2014(C 1 -C 6 )alkyl-, \u2014(C 2 -C 6 )alkenyl-, -aryl-, -heteroaryl-, \u2014(C 2 -C 6 )alkynyl-, \u2014(C 3 -C 8 )heterocyclyl-, \u2014(C 3 -C 14 )cycloalkyl, \u2014(C 1 -C 6 )alkyl-R 7 \u2014(C 1 -C 6 )alkyl-, \u2014(C 2 -C 6 )alkenyl-R 7 \u2014(C 1 -C 6 )alkyl-, \u2014(C 1 -C 6 )alkyl-R 7 \u2014(C 2 -C 6 )alkenyl-, \u2014(C 2 -C 6 )alkenyl-R 7 \u2014(C 2 -C 6 )alkenyl-, \u2014(C 1 -C 6 )alkyl-R 7 \u2014(C 2 -C 6 )alkynyl-, \u2014(C 2 -C 6 )alkenyl-R 7 \u2014(C 2 -C 6 )alkynyl-, \u2014(C 2 -C 6 )alkynyl-R 7 \u2014(C 2 -C 6 )alkynyl-, \u2014(C 2 -C 6 )alkynyl-R 7 \u2014(C 1 -C 6 )alkyl-, \u2014(C 2 -C 6 )alkynyl-R 7 \u2014(C 2 -C 6 )alkenyl-, \u2014(C 1 -C 6 )alkyl-OCO\u2014, or \u2014CH 2 \u2014(CHOR 7 )CH 2 O\u2014(C 1 -C 6 )alkyl-, where R 7  represents aryl, heteroaryl, (C 3 -C 8 )heterocyclyl, or (C 3 -C 14 )cycloalkyl, \n CORM represents a carbonyl metal complex selected from the group consisting of: where W represents O or NR 8 , where R 8  represents \u2014(C 1 -C 6 )alkyl-, L represents an ionic ligand, or a counter-ion, M represents Rh, Co, Ru, Mn, Mo, V or Fe, and n is an integer chosen so that the metal M has no free valency, X represent CR 10 R 11 , O, S, or NR 12  Y represent CR 10 R 11  if X represent O, S, or NR 12  otherwise Y represent O, S, or NR 12  \n where R 12  represent H, (C 1 -C 6 )alkyl, aryl, heteroaryl, (C 1 -C 6 )alkyl-aryl, (C 1 -C 6 )alkyl-heteroaryl, (C 1 -C 6 )alkyl-(C 3 -C 8 )heterocyclyl, or \u2014(C 3 -C 14 )cycloalkyl, R 9  and the atom representing CR 10 R 11  selected from X and Y, form together with the carbon atom bound to R 9 , a ring selected from an aryl, an heteroaryl, an (C 3 -C 8 )heterocyclyl, or an (C 3 -C 14 )cycloalkyl. \n where R 10  and R 11  are selected in order to fulfill the requirement for said ring and, if not involved in said ring, can independently represent single bond, H, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl.

Metadata:
- Claim Count in Document: 48.0
- Percentile: 90.0
- Lexical Diversity: 1.63333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15127674', '13940641', '12922122', '15510427', '12604970']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7912130024825695
- 35 USC 102 Novelty (BERT): 0.6144232013082361
- Combined Prediction Score: 0.7735340223651362
- Mean Citation Score: 389.86244
- Max Citation Score: 584.03534
- Similarity Product: 475.7507615921867

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test