PATENT CLAIM ANALYSIS

Application Number: 15914788
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "122000"]

Abstract:
Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome P450, a globin, a protoglobin, a nitric oxide dioxygenase, a peroxidase, or a catalase, or a variant thereof, under conditions sufficient to form the organoboron product. Reaction mixtures for producing organoboron products are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming carbon-boron bonds.

Claim (Index 34):
The method of  claim 31 , wherein the boron-containing reagent is a compound according to Formula IIa: wherein Y is selected from the group consisting of NR 4 , C(R 4 ) 2 , O, and S Z is selected from the group consisting of N and CR 5 ; R 3 , R 4 , R 5 , and R 6  are independently selected from the group consisting of H, optionally substituted C 1-18  alkyl, optionally substituted C 1-18  alkoxy, C 1-18  haloalkyl, C 2-18  alkenyl, C 2-18  alkynyl, optionally substituted C 6-10  aryl, optionally substituted 6- to 10-membered heteroaryl, optionally substituted 6- to 10-membered heterocyclyl, cyano, halo, nitro, N(R 8 ) 2 , B(R 9 ) 3 , Si(R 9 ) 3 , C(O)OR 7 , C(O)SR 7 , C(O)N(R 7 ) 2 , C(O)R 7 , C(O)ON(R 7 ) 2 , C(O)NR 7 OR 8 , C(O)C(O)OR 7 , and P(O)(OR 7 ) 2 ; or any two of R 3 , R 4 , R 5 , and R 6  are taken together with the atoms to which they are attached to form a 5- or 6-membered ring; and each R 7 , R 8 , and R 9  is independently selected from the group consisting of H, optionally substituted C 1-18  alkyl, optionally substituted C 1-18  alkoxy, C 2-18  alkenyl, C 2-18  alkynyl, optionally substituted C 6-10  aryl, optionally substituted 6- to 10-membered heteroaryl, and optionally substituted 6- to 10-membered heterocyclyl.

Metadata:
- Claim Count in Document: 35.0
- Percentile: 90.0
- Lexical Diversity: 1.61667
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15422360', '14625449', '14185861', '15278561', '14625514']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6043555048756726
- 35 USC 102 Novelty (BERT): 0.5161470662068924
- Combined Prediction Score: 0.5955346610087946
- Mean Citation Score: 245.779136
- Max Citation Score: 310.30655
- Similarity Product: 250.9848470095217

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test