PATENT CLAIM ANALYSIS

Application Number: 15870276
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["548", "400000"]

Abstract:
The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.

Claim (Index 1):
A method for treating a neurological disease, comprising:\n administering to a subject in need thereof an effective amount of a compound represented by formula I or a pharmaceutical acceptable salt thereof, wherein, X is selected from a group consisting of oxygen and sulfur; n is 1, 2 or 3; R 1  is H or halogen; R 2  and R 3  are each independently selected from a group consisting of H, D and C 1 -C 3  alkyl; or R 2  and R 3  together with the carbon atom to which they attached form C 3 -C 6  saturated ring; R 4  and R 5  are each independently selected from a group consisting of H; halogen; C 1 -C 6  alkyl; C 3 -C 6  cycloalkyl; cyano; C 1 -C 4  alkoxyl; C 1 -C 6  alkyl substituted by hydroxy, amino, C 1 -C 4  alkoxy, C 1 -C 4  alkylcarbonyl, or halogen; C 1 -C 4  alkoxy substituted by halogen; C 1 -C 6  alkylcarbonyl; C 1 -C 6  alkoxycarbonyl; C 1 -C 6  alkylaminocarbonyl; C 2 -C 6  alkenyl; and C 2 -C 6  alkynyl; provided that R 4  and R 5  are not simultaneously hydrogen; R 6  is selected from a group consisting of C 1 -C 6  alkoxy; C 1 -C 6  alkylamino; C 1 -C 6  alkyl; C 3 -C 6  cycloalkyl; C 2 -C 6  alkenyl; C 2 -C 6  alkynyl; C 6 -C 10  aryl; C 1 -C 6  alkyl substituted by halogen, cyano, hydroxy, C 1 -C 6  alkoxyl, di(C 1 -C 4  alkyl) amino, C 1 -C 6  alkylcarbonyl, C 1 -C 6  alkylcarbonylamino, or C 1 -C 6  alkoxycarbonyl; C 3 -C 6  cycloalkyl substituted by halogen; C 2 -C 6  alkenyl substituted by halogen; C 2 -C 6  alkynyl substituted by halogen; tetrahydrofuranyl; and wherein, R 7  and R 8  are each independently selected from a group consisting of C 1 -C 4  alkyl.

Metadata:
- Claim Count in Document: 47.0
- Percentile: 86.0
- Lexical Diversity: 1.5
- Patent Class: 548.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15306971', '14353842', '15513357', '13139830', '12663432']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6913033385931024
- 35 USC 102 Novelty (BERT): 0.5802153283857883
- Combined Prediction Score: 0.680194537572371
- Mean Citation Score: 299.658052
- Max Citation Score: 475.04092
- Similarity Product: 411.5435724283266

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test