PATENT CLAIM ANALYSIS

Application Number: 16394571
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["514", "254010"]

Abstract:
Phenyldifluoromethyl-substituted prolinamide compounds that have a cathepsin S inhibitory effect, and are usable as active ingredients of pharmaceutical compositions for preventing and/or treating autoimmune diseases including systemic lupus erythematosus (SLE) and lupus nephritis, allergies, or graft rejection of an organ, bone marrow or tissue. Such compounds include (4R)—N-(1-cyanocyclopropyl)-4-(difluoro{4-[(4-methylpiperazin-1-yl)methyl]-2-(trifluoromethyl)phenyl}methyl)-1-[(1-methylcyclopropyl)carbonyl]-L-prolinamide, (4R)—N-(1-cyanocyclopropyl)-4-(difluoro{4-[(4-methylpiperazin-1-yl)methyl]-2-(trifluoromethyl)phenyl}methyl)-1-{[1-(trifluoromethyl)cyclopropyl]carbonyl}-L-prolinamide, (4R)—N-(1-cyanocyclopropyl)-4-[{4-[(4-ethylpiperazin-1-yl)methyl]-2-(trifluoromethyl)phenyl}(difluoro)methyl]-1-{[1-(trifluoromethyl)cyclopropyl]carbonyl}-L-prolinamide, (4R)—N-(1-cyanocyclopropyl)-4-[{4-[(4-ethylpiperazin-1-yl)methyl]-2-(trifluoromethyl)phenyl}(difluoro)methyl]-1-[(1-methylcyclopropyl)carbonyl]-L-prolinamide, and salts thereof.

Claim (Index 14):
A method for preventing or treating an autoimmune disease selected from the group consisting of systemic lupus erythematosus, lupus nephritis, an allergy, and graft rejection of an organ, bone marrow or tissue, the method comprising administering to a subject in need thereof an effective amount of the compound or salt thereof according to  claim 7 .

Metadata:
- Claim Count in Document: 29.0
- Percentile: 100.0
- Lexical Diversity: 3.0
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['16180862', '15017914', '13649670', '14506760', '13115462']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7799537720808567
- 35 USC 102 Novelty (BERT): 0.5752635031456025
- Combined Prediction Score: 0.7594847451873312
- Mean Citation Score: 355.23736999999994
- Max Citation Score: 550.89105
- Similarity Product: 351.92911491791006

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test