PATENT CLAIM ANALYSIS

Application Number: 15756483
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "002400"]

Abstract:
Disclosed are synthetic peptides and peptide compositions, including peptide conjugates, that can ameliorate and/or block the cytotoxicity of  C. difficile  TcdB toxin, and methods of their use for inhibiting the activity of TcdB and protecting against damage during  C. difficile  disease, and/or for use as cell penetrating peptides for enhancing the delivery of particular heterogenous molecules into cells.

Claim (Index 10):
A pharmaceutical composition, comprising:\n a peptide disposed in a pharmaceutically-acceptable carrier or vehicle, the peptide comprising an amino acid sequence:\n X 1  X 2  X 3  X 4  X 5  X 6  X 7  X 8  X 9  X 10  X II  X 12  X 13  X 14  X 15  X 16  X 17  X 18  X 19  (SEQ ID NO:68), wherein \n each of X 1 , X 2 , X 3 , X 4 , X 7 , X 8 , X 9 , X 10 , X 11 , X 12 , X 13 , X 14 , X 15 , X 16 , X 17 , X 18 , and X 19  is independently selected from the group consisting of gly, L-ala, L-arg, L-asn, L-asp, L-cys, L-glu, L-gln, L-his, L-ile, L-leu, L-lys, L-met, L-phe, L-pro, L-ser, L-Thr, L-trp, L-tyr, L-val, D-ala, D-arg, D-asn, D-asp, D-cys, D-glu, D-gln, D-his, D-ile, D-leu, D-lys, D-met, D-phe, D-pro, D-ser, D-thr, D-trp, D-tyr, and D-val; \n X 5  is selected from gly, L-ala, and D-ala; and \n X 6  is selected from L-asn, L-gln, L-his, D-asn, D-gln, and D-his; and \n wherein the peptide has at least 73% identity with SEQ ID NO:6, and has inhibitory activity against TcdB toxins and/or cell penetrating activity.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 88.0
- Lexical Diversity: 1.43182
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['10196394', '13262186', '15119058', '14005135', '10202915']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7938158713447451
- 35 USC 102 Novelty (BERT): 0.5338968154851051
- Combined Prediction Score: 0.7678239657587811
- Mean Citation Score: 370.798698
- Max Citation Score: 375.74005
- Similarity Product: 237.82903481284973

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test