PATENT CLAIM ANALYSIS

Application Number: 15870557
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["514", "230500"]

Abstract:
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

Claim (Index 33):
A compound of Formula II, or a pharmaceutically acceptable salt thereof, wherein,\n Ring B is an optionally substituted 5- or 6-membered heteroaryl ring containing at least one S or N atom, or an optionally substituted 5- or 6-membered heterocyclyl ring containing at least one S or N atom; \n X2 is N or C\u2014R 12 , wherein R 12  is hydrogen, halogen, alkyl, or alkoxy; \n X3 is N or C\u2014R 13 , wherein R 13  is \u2014Y\u2014Z, in which \n Y is a bond, \u2014CH 2 \u2014, or \u2014CH(C 1 -C 4  alkyl)-; Z is \u2014SO 2 R b , \u2014N(R a )SO 2 R b , \u2014SO 2 N(R a ) 2 , \u2014N(R a )SO 2 N(R a ) 2 , \u2014CON(R a ) 2 , \u2014N(R a )CO 2 R a , \u2014N(R a )CON(R a ) 2 , \u2014N(R a )COR a , \u2014OC(O)N(R a ) 2 , \u2014OSO 2 N(R a ) 2 , or \u2014N(R a )SO 3 R b ; each R a  is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; and R b  is selected from alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl;\n X6 is N or C\u2014R 16 , wherein R 16  is hydrogen, halogen, or \u2014W\u2014X, wherein W is a bond, \u2014O\u2014, \u2014S\u2014, or \u2014NH\u2014, and X is alkyl, alkynyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkynyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; \n and\n G is described by: \n wherein,\n R 22  is alkyl; \n R 23  is hydrogen, halogen, or alkyl; or, optionally, when R 23  is alkyl, then R 22  and R 23  join to form an optionally substituted ring; \n R 25  is hydrogen, halogen, alkyl, alkoxy, or alkenyl; \n R 26  is hydrogen, halogen, alkyl, alkoxy, aminoalkyl, or alkenyl; or, optionally, when R 23  is hydrogen, R 25  is not hydrogen and R 26  is not hydrogen or halogen, then R 25  and R 26  join to form an optionally substituted ring.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 86.0
- Lexical Diversity: 1.425
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15130503', '14517705', '15488674', '14658048', '14789881']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.851104884231835
- 35 USC 102 Novelty (BERT): 0.5974761369781834
- Combined Prediction Score: 0.8257420095064698
- Mean Citation Score: 490.161302
- Max Citation Score: 508.7241
- Similarity Product: 491.42291236066825

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test