PATENT CLAIM ANALYSIS

Application Number: 16091764
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-04
Patent Classification: ["564", "415000"]

Abstract:
A process for preparation of 4-aminoindane derivatives of a first formula, salts and enantiomers thereof comprising the steps of: a) hydrogenating a 1,2-dihydroquinoline of a second formula to give a corresponding tetrahydroquinoline of a third formula; b) acylating the tetrahydroquinoline of the third formula with a carboxylic acid derivative of a fourth formula to obtain a corresponding acyl derivative compound of a fifth formula; c) rearranging the acyl derivative compound of the fifth formula under acidic conditions so as to give an acyl indane compound of a sixth formula; and d) hydrolysing the acyl group of the acyl indane compound of the sixth formula so as to obtain the 4-aminoindane derivatives of the first formula.

Claim (Index 13):
A process for preparation of aminoindane amides of Formula (II), comprising the steps of:\n preparing at least one 4-aminoindane derivative of Formula (I) by carrying out the steps (a)-(d) of the process of  claim 1 ; and \n condensing the 4-aminoindane derivative of Formula (I) with at least one compound of Formula AC(O)X; \n wherein in the formulae:\n A represents a C 6 -C 10  aryl group or a heterocyclic ring with 5 or 6 atoms containing from 1 to 3 heteroatoms selected from N, O, S, these groups being optionally substituted by one or more R 1  and R 2  groups; \n R 1  represents a C 1 -C 6  alkyl group or a C 1 -C 6  haloalkyl group, the groups being optionally substituted with one or more groups selected from R\u2032, OR\u2032, S(O) m R\u2032; or R 1  represents a C 3 -C 6  cycloalkyl group, a C 4 -C 9  cycloalkylalkyl group, a C 2 -C 6  alkenyl group, a C 2 -C 6  alkinyl group, a C 6 -C 10  aryl group, a C 7 -C 12  arylalkyl group, a heterocyclic ring with 5 or 6 atoms containing from 1 to 3 heteroatoms selected from N, O, S, these groups being optionally substituted by one or more groups selected from halogen atoms, R\u2032, OR\u2032, NR\u2032R\u2033, S(O) m R\u2032, CONR\u2032R\u2033, COR\u2032, CO 2 R\u2032, CN, NO 2 ; \n R 2  represents a C 1 -C 6  alkyl group or a C 1 -C 6  haloalkyl group, the groups being optionally substituted with one or more groups selected from R\u2032, OR\u2032, S(O) m R\u2032; or R 2  represents a C 3 -C 6  cycloalkyl group, a C 4 -C 9  cycloalkylalkyl group, a C 6 -C 10  aryl group, a C 7 -C 12  arylalkyl group, these groups being optionally substituted by one or more groups selected from halogen atoms, R\u2032, OR\u2032, S(O) m R\u2032, NR\u2032R\u2033, CONR\u2032R\u2033, COR\u2032, CO 2 R\u2032, NO 2 , CN; \n R\u2032 and R\u2033 represent a hydrogen atom, a C 1 -C 4  alkyl group, a C 1 -C 4  haloalkyl group; \n X represents a hydroxyl group, a halogen, a C 1 -C 6  alkoxy group, a C 1 -C 6  alkylsulfonyloxy group, a C 6 -C 10  arylsulfonyloxy group, these groups being optionally substituted by one or more halogen atoms; \n n is an integer selected within the range from 0 to 3, inclusive; and \n m is an integer selected within the range from 0 to 2, inclusive.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 97.0
- Lexical Diversity: 2.31481
- Patent Class: 564.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15117058', '12295618', '13933961', '14768082', '11874218']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.68999000749611
- 35 USC 102 Novelty (BERT): 0.5056976993800713
- Combined Prediction Score: 0.6715607766845061
- Mean Citation Score: 174.69682
- Max Citation Score: 177.10905
- Similarity Product: 119.81449798121452

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test