PATENT CLAIM ANALYSIS

Application Number: 15882924
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-09
Patent Classification: ["514", "252160"]

Abstract:
The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

Claim (Index 3):
A compound of Formula (IIa): wherein R 1  is H, or\n NR c R d  wherein R c  is H, C 1-4  alkyl or 3-7 member cyclic ring, said 3-7 member cyclic ring optionally substituted with C 1-4  alkyl optionally substituted with OZ or NR 10 R 11  wherein Z, R 10  and R 11  are independently H or C 1-4  alkyl, or said 3-7 member cyclic ring being optionally substituted with R 8 CO, wherein R 8  is C 1-4  alkyl, or said 3-7 member cyclic ring being optionally substituted with SO 2 (CH 2 ) q H, wherein q is 1-4, and R d  is H, C 1-4  alkyl, optionally substituted with OZ or NR 10 R 11  wherein Z, R 10  and R 11  are H or C 1-4  alkyl; or \n NR e R f  wherein R e  is C 1-4  alkyl, and R f  is 3-7 member cyclic ring optionally substituted with C 1-4  alkyl optionally substituted with halo; or \n OR g  wherein R g  is C 1-4  alkyl substituted with CH 3 O\u2014, CH 3 CH 2 O\u2014, CH 3 (O) 2 S\u2014, CF 3 O\u2014, \n or\n 3-7 member cyclic ring substituted with R a  wherein R a  is C 1-8  alkyl optionally substituted with halo, C 1-4  alkoxy or SO 2 (CH 2 ) q H, wherein q is 1-4, or said 3-7 member cyclic ring being optionally substituted with R 8 CO, wherein R 8  is C 1-4  alkyl; \n R 2  is absent, H, halo, C 1-4  alkyl, C 1-4  alkoxy, or alkylamine (NR 10 R 11 ), wherein R 10  and R 11  are independently H or C 1-4  alkyl; \n R 3  is absent, H, halo, C 1-4  alkyl, or C 1-4 alkoxy, or alkylamine (NR 10 R 11 ), wherein R 10  and R 11  are independently H or C 1-4  alkyl; \n R 5  is absent, H, halo, C 1-4  alkyl, or C 1-4 alkoxy, or alkylamine (NR 10 R 11 ), wherein R 10  and R 11  are independently H or C 1-4  alkyl; \n R 6  is H, halo, C 1-4  alkyl, or C 1-4 alkoxy, or alkylamine (NR 10 R 11 ), wherein R 10  and R 11  are independently H or C 1-4  alkyl; \n R 7  is H, halo, C 1-4  alkyl, C 1-4  alkoxy, or alkylamine (NR 10 R 11 ), wherein R 10  and R 11  are independently H or C 1-4  alkyl; \n R 9  is H, halo, C 1-4  alkyl, or C 1-4 alkoxy, or alkylamine (NR 10 R 11 ), wherein R 10  and R 11  are independently H or C 1-4  alkyl; or \n R 1  and R 5  are part of 3-7 member cyclic ring, optionally substituted with C 1-4  alkyl optionally substituted with OZ or NR 10 R 11  wherein Z, R 10  and R 11  are independently H or C 1-4  alkyl; or \n R 1  and R 2  are part of 3-7 member cyclic ring, optionally substituted with C 1-4  alkyl optionally substituted with OZ or R 10  and R 11  wherein Z, R 10  and R 11  are independently are H or C 1-4  alkyl; or \n R 2  and R 6  are part of 3-7 member cyclic ring, optionally substituted with C 1-4  alkyl optionally substituted with OZ or R 10  and R 11  wherein Z, R 10  and R 11  are independently H or C 1-4  alkyl; \n R 4  is C 2  alkenyl optionally substituted with C 1-4  alkyl, \u2014CH 2 OCH 3 , or \u2014CH 2 N(CH 3 ) 2 ; \n X is O, C 1-4  alkyl optionally substituted with halo, or NR b , wherein R b  is H, or C 1-8  alkyl optionally substituted with halo; \n Y is C, CH optionally substituted with halo, or N; \n A is C, CH optionally substituted with halo, or N; and \n B is C, CH optionally substituted with halo, or N, \n or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 66.0
- Percentile: 86.0
- Lexical Diversity: 1.68182
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14329890', '16068559', '13436910', '14712794', '13436963']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7785083446627168
- 35 USC 102 Novelty (BERT): 0.5604657962467278
- Combined Prediction Score: 0.7567040898211179
- Mean Citation Score: 306.409536
- Max Citation Score: 426.96307
- Similarity Product: 391.49976072250007

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test