PATENT CLAIM ANALYSIS

Application Number: 15987277
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "210180"]

Abstract:
Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Claim (Index 8):
A compound or pharmaceutically acceptable salt according to  claim 1 , which is selected from the group consisting of\n 4-(tert-Butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)-6-(3-((1S,4R)-4-((3-(tert-pentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-(tert-pentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)-6-(3-((1S,4R)-4-((3-(tert-pentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-Butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-Butyl)-N-(2-(3-methoxyazetidin-1-yl)ethyl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)-2-methylpropyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-Butyl)-6-(3-((1S,4R)-4-((3-((S)-sec-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)-2-methylpropyl)pyrimidine-2-carboxamide; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy]-1,2,3,4-tetrahydronaphthalen-1-yl}ureido)-N-(2-(4-hydroxypiperidin-1-yl)ethyl)picolinamide; 6-(tert-Butyl)-4-(3-((1S,4R)-4-((3-(diethylamino)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)picolinamide; 4-(tert-Butyl)-6-(3-((1S,4R)-4-((3-(diethylamino)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(ethyl(methyl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy]-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 1-(6-(tert-butyl)-2-(hydroxymethyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridine-6-yl)oxy)-1,2,3,4-tetrahydronaphthalene-1-yl)urea; 1-(6-(tert-Butyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(6-(tert-Butyl)-2-((dimethylamino)methyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-2-methylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-hydroxyethyl)pyrimidine-2-carboxamide; 4-(tert-Butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-Butyl)-6-(3-((1S,4R)-4-((3-((2R,6S)-2,6-dimethylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 4-(tert-Butyl)-6-(3-((1S,4R)-4-((3-((2R,6S)-2,6-dimethylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-hydroxyethyl)pyrimidine-2-carboxamide; 4-(tert-Butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-((2R,6S)-2,6-dimethylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 1-(6-(tert-Butyl)-2-(morpholinomethyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-Butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-(2-(4-methylpiperazin-1-yl)propan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 1-(6-(tert-Butyl)-2-(hydroxymethyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(2-(4-methylpiperazin-1-yl)propan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; N-((4-(tert-Butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidin-2-yl)methyl)-2-(dimethylamino)acetamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(1-methylcyclopentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; (4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidin-2-yl)methyl acetate; 1-(6-(tert-butyl)-2-(hydroxymethyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-hydroxyethyl)pyrimidine-2-carboxamide; N-(4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidin-2-yl)methanesulfonamide; 1-(6-(tert-butyl)-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-(1-methylcyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-hydroxyethyl)-6-(3-((1S,4R)-4-((3-(morpholine-4-carbonyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-((S)-2-methylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 1-(5-(tert-butyl)-2-methoxypyridin-3-yl)-3-((1S,4R)-4-((3-((S)-1-methylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea hydrochloride salt; Ethyl 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxylate; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-((S)-2-methylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-methylpyrimidine-2-carboxamide; 1-(4-(tert-butyl)-6-cyanopyridin-2-yl)-3-((1S,4R)-4-((3-((R)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(6-(tert-Butyl)-2-methylpyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(6-(tert-Butyl)-2-ethylpyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(6-(tert-Butyl)-2-isopropylpyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(6-(tert-Butyl)-2-(methoxymethyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(4-(tert-butyl)pyridin-2-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(6-(tert-butyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-2-methylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(6-(tert-butyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1-methylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridine-6-yl)oxy)-1,2,3,4-tetrahydronaphthalene-1-yl)urea hydrochloride; 1-(6-(tert-butyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1-isopropylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridine-6-yl)oxy)-1,2,3,4-tetrahydronaphthalene-1-yl)urea hydrochloride; 1-(6-(tert-butyl)-2-(methylthio)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1-[1,2,4]triazolo[4,3-a]pyridine-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(6-(tert-butyl)-2-(methylthio)pyrimidin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridine-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(2-(tert-Butyl)-5-methylpyridin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(2-(tert-Butyl)-6-(hydroxymethyl)pyridin-4-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(5-(tert-butyl)-2-methoxypyridin-3-yl)-3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 6-(tert-Butyl)-4-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-methylpicolinamide; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-(methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-(3-methyloxetan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-((S)-1-methoxyethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalene-1-yl)ureido)pyrimidin-2-carboxamide; 1-(2-(tert-butyl)-6-((2-morpholinoethoxy)methyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)picolinamide; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-neopentyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-hydroxyethyl)-6-(3-((1S,4R)-4-((3-isobutyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 6-(tert-Butyl)-4-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-hydroxyethyl)picolinamide; 6-(tert-Butyl)-N-(2-(dimethylamino)ethyl)-4-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide; 1-(6-(tert-Butyl)-2-((2-morpholinoethoxy)methyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-cyclopentyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-hydroxyethyl)-6-(3-((1S,4R)-4-((3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-methoxyethyl)(methyl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-morpholinoethyl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-methoxyethyl)(methyl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-(morpholine-4-carbonyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-hydroxyethyl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-((2-methoxyethyl)(methyl)amino)ethyl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-cyclopentyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-cyclopentyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-cyclopentyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-methoxyethyl)(methyl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(3-hydroxyazetidin-1-yl)ethyl)pyrimidine-2-carboxamide; 1-(6-(tert-butyl)-2-(3,3-difluoroazetidine-1-carbonyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(3-morpholinopropyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(1-methylazetidin-3-yl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-hydroxyethyl)-N-methylpyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-((1S,3R)-3-(hydroxymethyl)cyclobutyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(1-methylazetidin-3-yl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; N-(2-(bis(2-methoxyethyl)amino)ethyl)-4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[l 1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 1-(2-((bis(2-methoxyethyl)amino)methyl)-6-(tert-butyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(2-((bis(2-hydroxyethyl)amino)methyl)-6-(tert-butyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 1-(6-(tert-butyl)-2-(((2-hydroxyethyl)(methyl)amino)methyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; N-(2-(1,4-oxazepan-4-yl)ethyl)-4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-isobutyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-isobutyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; N-(2-(bis(2-methoxyethyl)amino)ethyl)-4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((S)-3-hydroxypyrrolidin-1-yl)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(3-methyloxetan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-morpholinoethyl)-6-(3-((1S,4R)-4-((3-neopentyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-sec-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-1-methoxyethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-sec-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; N-((4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidin-2-yl)methyl)-3-morpholinopropanamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(3-methoxyazetidin-1-yl)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-sec-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-methoxyethyl)(methyl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-((2-methoxyethyl)(methyl)amino)ethyl)-6-(3-((1S,4R)-4-((3-((S)-1-methoxyethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(methyl(oxetan-3-yl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(4-hydroxypiperidin-1-yl)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(1-methylcyclobutyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-morpholinoethyl)pyrimidine-2-carboxamide; (S)\u2014N-((4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidin-2-yl)methyl)-1-methylpyrrolidine-2-carboxamide; N-(3-(1,4-Oxazepan-4-yl)propyl)-4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide partial formate salt; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(1-(dimethylamino)-2-methylpropan-2-yl)pyrimidine-2-carboxamide; 1-(6-(tert-Butyl)-2-((3-oxopiperazin-1-yl)methyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea partial formate salt; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(ethyl(methyl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)-N-methylpyrimidine-2-carboxamide; 1-(6-(tert-butyl)-2-(4-(2-hydroxyethyl)piperazine-1-carbonyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)-2-methylpropyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(3-(dimethylamino)propyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(4-methylpiperazin-1-yl)ethyl)pyrimidine-2-carboxamide; N-(2-(bis(2-hydroxyethyl)amino)ethyl)-4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(3-morpholinopropyl)pyrimidine-2-carboxamide; N-(2-(1,4-oxazepan-4-yl)ethyl)-4-(tert-butyl)-6(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(3-morpholinopropyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; N-((4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidin-2-yl)methyl)-1-methylazetidine-3-carboxamide; N-((4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidin-2-yl)methyl)-3-(dimethylamino)propanamide; 1-(6-(tert-butyl)-2-(4-methylpiperazine-1-carbonyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N\u2014((R)-1-methylpyrrolidin-3-yl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(2-(dimethylamino)ethoxy)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-morpholinoethyl)-6-(3-((1S,4R)-4-((3-(tert-pentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(3-morpholinopropyl)-6-(3-((1S,4R)-4-((3-(tert-pentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 1-(6-(tert-butyl)-2-(4-methyl-1,4-diazepane-1-carbonyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(1-methylpiperidin-4-yl)pyrimidine-2-carboxamide; 1-(6-(tert-Butyl)-2-((4-methyl-2-oxopiperazin-1-yl)methyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea formate salt; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N\u2014((S)-1-methylpyrrolidin-3-yl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-((2-methoxyethyl)(methyl)amino)ethyl)-6-((1S,4R)-4-((3-(1-methylcyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(3-methoxyazetidin-1-yl)ethyl)-6-(3-((1S,4R)-4-((3-(1-methylcyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-hydroxyethyl)-6-(3-((1S,4R)-4-((3-(2-(4-methylpiperazin-1-yl)propan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; N-(2-(azetidin-1-yl)ethyl)-4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)-2-methylpropyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(diethylamino)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(diethylamino)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)-2-methylpropyl)pyrimidine-2-carboxamide; 1-(6-(tert-butyl)-2-((2-morpholinoethoxy)methyl)pyrimidin-4-yl)-3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 4-(tert-butyl)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)-6-(3-((1S,4R)-4-((3-(1-methylcyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-sec-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(ethyl(methyl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)-2-ethylbutyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(ethyl(methyl)amino)-2-methylpropyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-((1-(dimethylamino)cyclopropyl)methyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-((4-(dimethylamino)tetrahydro-2H-pyran-4-yl)methyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-methyl-2-(4-methylpiperazin-1-yl)propyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(ethyl(methyl)amino)-2-methylpropyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-((1-(dimethylamino)cyclohexyl)methyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-((1-(dimethylamino)cyclopentyl)methyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-methyl-2-(4-methylpiperazin-1-yl)propyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(ethyl(methyl)amino)-2-methylpropyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-methyl-2-(4-methylpiperazin-1-yl)propyl)pyrimidine-2-carboxamide; 4-(tert-Butyl)-N-((1-(dimethylamino)cyclobutyl)methyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide formate salt; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-((1-(dimethylamino)cyclopropyl)methyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-((4-(dimethylamino)tetrahydro-2H-pyran-4-yl)methyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-((1-(dimethylamino)cyclohexyl)methyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-((1-(dimethylamino)cyclobutyl)methyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-((1-(dimethylamino)cyclopentyl)methyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(cyclopropyl(methyl)amino)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-((1 S,2S)-2-(dimethylamino)cyclohexyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(3-methoxyazetidin-1-yl)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(3-methoxyazetidin-1-yl)ethyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)-2-ethylbutyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-((S)-sec-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(3-methoxyazetidin-1-yl)ethyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(3-methoxyazetidin-1-yl)-2-methylpropyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(3-methoxyazetidin-1-yl)-2-methylpropyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(3-methoxyazetidin-1-yl)-2-methylpropyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-methyl-2-(4-methylpiperazin-1-yl)propyl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide formate salt; 4-(tert-butyl)-N-(2-(3-methoxyazetidin-1-yl)-2-methylpropyl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide formate salt; 4-(tert-butyl)-N-(2-(dimethylamino)-2-methylpropyl)-6-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide formate salt; 4-(tert-butyl)-N-(2-(ethyl(methyl)amino)-2-methylpropyl)-6-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-methoxyethyl)(methyl)amino)-2-methylpropyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-methoxyethyl)(methyl)amino)-2-methylpropyl)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-((2-methoxyethyl)(methyl)amino)-2-methylpropyl)-6-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-Butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-(2-ethoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide formate salt; 4-(tert-butyl)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)-6-(3-((1S,4R)-4-((3-(1-methylcyclopentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; N-(2-(1,4-oxazepan-4-yl)ethyl)-4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(1-methylcyclopentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-butyl)-N-(2-(dimethylamino)-2-methylpropyl)-6-(3-((1S,4R)-4-((3-(1-methylcyclopentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; 4-(tert-Butyl)-6-(3-((1S,4R)-4-((3-(1-methylcyclopentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(3-morpholinopropyl)pyrimidine-2-carboxamide formate salt; 6-(tert-butyl)-N-(2-(dimethylamino)ethyl)-4-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)picolinamide; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(3-morpholinopropyl)picolinamide; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)picolinamide; N-(2-(1,4-oxazepan-4-yl)ethyl)-6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide; 6-(tert-butyl)-N-(2-(dimethylamino)ethyl)-4-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(ethyl(methyl)amino)ethyl)picolinamide; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-methoxyethyl)(methyl)amino)ethyl)picolinamide; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(3-methoxyazetidin-1-yl)ethyl)picolinamide; 6-(tert-butyl)-N-(2-(dimethylamino)-2-methylpropyl)-4-(3-((1S,4R)-4-((3-(2-methoxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((S)-3-hydroxypyrrolidin-1-yl)ethyl)picolinamide; 6-(tert-butyl)-N-(2-(dimethylamino)-2-methylpropyl)-4-(3-((1S,4R)-4-((3-(1-methoxy-2-methylpropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(3-hydroxyazetidin-1-yl)ethyl)picolinamide; 1-(2-(tert-butyl)-6-(hydroxymethyl)pyridin-4-yl)-3-((1S,4R)-4-((3-(2-(4-methylpiperazin-1-yl)propan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)urea; 6-(tert-Butyl)-N-(2-(dimethylamino)ethyl)-4-(3-((1S,4R)-4-((3-(2-(4-methylpiperazin-1-yl)propan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide formate salt; 6-(tert-Butyl)-N-(2-hydroxyethyl)-4-(3-((1S,4R)-4-((3-(2-(4-methylpiperazin-1-yl)propan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide formate salt; 6-(tert-Butyl)-4-(3-((1S,4R)-4-((3-((S)-sec-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)ethyl)picolinamide formate salt; 6-(tert-Butyl)-4-(3-((1S,4R)-4-((3-((S)-sec-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)-2-methylpropyl)picolinamide formate salt; 6-(tert-butyl)-4-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(4-methoxypiperidin-1-yl)ethyl)picolinamide; 6-(tert-Butyl)-4-(3-((1S,4R)-4-((3-(diethylamino)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(dimethylamino)-2-methylpropyl)picolinamide formate salt; 6-(tert-Butyl)-4-(3-((1S,4R)-4-((3-(diethylamino)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(ethyl(methyl)amino)ethyl)picolinamide formate salt; 6-(tert-butyl)-N-(2-(dimethylamino)ethyl)-4-(3-((1S,4R)-4-((3-(tert-pentyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide; 6-(tert-butyl)-N-(2-(dimethylamino)ethyl)-4-(3-((1S,4R)-4-((3-(pentan-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)picolinamide formate salt; N-(2-(1,4-oxazepan-4-yl)ethyl)-4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)picolinamide formate salt; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N-(2-(3-methoxyazetidin-1-yl)ethyl)picolinamide formate salt; 4-(tert-butyl)-6-(3-((1S,4R)-4-((3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)-N\u2014(\u2212(2-(4-hydroxypiperidin-1-yl)ethyl)picolinamide formate salt; N-(6-(tert-Butyl)-4-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyridin-2-yl)methanesulfonamide; N-(6-(tert-Butyl)-4-(3-((1S,4R)-4-((3-((S)-1,2-dimethylpyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyridin-2-yl)ethanesulfonamide; 4-(tert-Butyl)-N-(2-(dimethylamino)ethyl)-6-(3-((1S,4R)-4-((3-((R)-4-methylmorpholin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide; and 4-(tert-Butyl)-N-(2-((2-hydroxyethyl)(methyl)amino)ethyl)-6-(3-((1S,4R)-4-((3-((R)-4-methylmorpholin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido)pyrimidine-2-carboxamide.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 1.18519
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15388350', '14296730', '14895718', '14868516', '14296794']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8504068621865363
- 35 USC 102 Novelty (BERT): 0.5921512810089768
- Combined Prediction Score: 0.8245813040687804
- Mean Citation Score: 514.875808
- Max Citation Score: 525.1804
- Similarity Product: 430.60175203661913

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test