PATENT CLAIM ANALYSIS

Application Number: 15742459
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-09
Patent Classification: ["424", "200100"]

Abstract:
Disclosed is the attenuated  Salmonella typhi  vaccine Ty21a utilized as a vector for  Shigella  and/or enterotoxogenic  E. coli  genes stably integrated in the Ty21a chromosome. These genes include a heterologous  Shigella sonnei  O-antigen biosynthetic gene region that comprises the wzz gene and expresses  Shigella sonnei  form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.

Claim (Index 16):
A transgenic  Salmonella typhi  Ty21a comprising a heterologous enterotoxogenic  E. coli  (ETEC) antigen biosynthetic gene region and a heterologous acid resistance biosynthetic gene system, wherein said ETEC antigen biosynthetic gene region and said acid resistance biosynthetic gene system are both integrated into the  Salmonella typhi  Ty21a chromosome, and wherein:\n a. an ETEC antigen is stably expressed; b. one or more heterologous  Shigella  acid resistance enzymes comprising a YbaS gene, are stably expressed; c. said transgenic  Salmonella typhi  Ty21a is more acid stable at pH 2.5 than  Salmonella typhi  Ty21a without the integrated acid resistance biosynthetic gene system; d. an immune response is elicited against virulent Enterotoxogenic  E. coli  challenge; and/or e. an immune response is elicited against virulent  Salmonella typhi  challenge.

Metadata:
- Claim Count in Document: 23.0
- Percentile: 86.0
- Lexical Diversity: 1.54386
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14428870', '10346706', '14660498', '13686299', '13295811']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7561433334033664
- 35 USC 102 Novelty (BERT): 0.6043869532448687
- Combined Prediction Score: 0.7409676953875166
- Mean Citation Score: 466.43767
- Max Citation Score: 575.4499
- Similarity Product: 448.539843489772

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test