PATENT CLAIM ANALYSIS

Application Number: 16042936
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["600", "485000"]

Abstract:
Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine a plurality of baseline values for a parameter related to endothelial function as a function of applied pressure (P m ); b) applying a stimulus to the subject; and applying external pressure P m  to the artery to determine a plurality of stimulus-effected values for the parameter related to endothelial function as a function of applied pressure (P m ); where the baseline values are determined from measurements made when said mammal is not substantially effected by said stimulus and differences in said baseline values and said stimulus-effected values provide a measure of endothelial function in said mammal.

Claim (Index 1):
A method of assessing cardiovascular function in a mammal, said method comprising:\n a) determining the systolic and diastolic blood pressure of said mammal wherein said the systolic and diastolic blood pressure comprises determining the pulse height as a function of applied external pressure P m  to an artery; b) applying a substantially constant external pressure P m  to an artery for a first period of time T m , to provide a reduced transmural pressure, and determining, over the course of one or more cardiac cycles in said first period of time T m , changes in pressure in said artery resulting from cardiac activity of said mammal, or an artificially induced arterial pulse, to establish a baseline value for a parameter related to endothelial function in said mammal; c) applying an arterial stimulus to said mammal; and d) applying said substantially constant external pressure P m  to said artery for a second period of time T m , to provide a reduced transmural pressure, and determining, over the course of one or more cardiac cycles in said second period of time T m , changes in pressure in said artery resulting from cardiac activity of said mammal, or an artificially induced arterial pulse, to provide a stimulus-affected parameter related to endothelial function in said mammal; e) determining the systolic and diastolic blood pressure of said mammal; f) fitting the data obtained in step (a) to determine a first model relating pulse height to transmural pressure and using said first non-linear model to convert said baseline value for a parameter related to endothelial function to a baseline value for a parameter related to endothelial function at a reference pressure; g) fitting the data obtained in step (e) to determine a second non-linear model relating pulse height to transmural pressure and using said second model to convert said stimulus-affected value for a parameter related to endothelial function to a stimulus-affected parameter related to endothelial function at said reference pressure; h) using said baseline value for a parameter related to endothelial function at a reference pressure to calculate baseline arterial lumen area (A b ) or a measure proportional to the area A b  at said reference pressure; i) using said stimulus-affected value for a parameter related to endothelial function at a reference pressure to calculate stimulus-affected arterial lumen area (A r ) or a measure proportional to the area A r  at said reference pressure; and j) determining the equivalent ultrasound-based FMD (uFMD) measure where uFMD is proportional to the square root of the ratio A r /A b , and where said baseline values are determined from measurements made when said mammal is not substantially affected by said stimulus and uFMD provides a measure of cardiovascular function in said mammal.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 95.0
- Lexical Diversity: 2.2623
- Patent Class: 600.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15680082', '15236250', '15741185', '12483930', '13252245']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6013876185270709
- 35 USC 102 Novelty (BERT): 0.6631701691026792
- Combined Prediction Score: 0.6075658735846318
- Mean Citation Score: 434.9785
- Max Citation Score: 589.7051
- Similarity Product: 495.49676674349314

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test