PATENT CLAIM ANALYSIS

Application Number: 16112015
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-12
Patent Classification: ["536", "053000"]

Abstract:
The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.

Claim (Index 3):
A method for obtaining anti-inflammatory effect, the method comprising:\n administering a pharmaceutical composition to a living body, wherein the pharmaceutical composition comprises: a group derived from glycosaminoglycan, a group derived from a physiologically active substance, and a spacer which couples the group derived from glycosaminoglycan to the group derived from the physiologically active substance by a covalent bond, wherein the glycosaminoglycan is at least one selected from the group consisting of a chondroitin sulfate, and a derivative thereof, wherein the physiologically active substance is selected from a group consisting of a nonsteroidal anti-inflammatory drug and a steroid, and the group derived from the physiologically active substance and the spacer are covalently bonded through an ester bond, wherein the glycosaminoglycan has a carboxy group, a molecule for forming the spacer has an amino group corresponding to the carboxy group of the glycosaminoglycan, and the group derived from glycosaminoglycan and the spacer are covalently bonded through an amide bond, wherein the molecule for forming the spacer has a coupling group which may have one or more substituent and couples the carboxy group and the amino group and the length of the coupling group between the carboxy group and the amino group is 2 to 12 atoms, and wherein a dissociation rate of the physiologically active substance from the glycosaminoglycan derivative is 0.1 to 20%/day in a phosphate buffered saline with pH of 7.5 at 36\u00b0 C.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 96.0
- Lexical Diversity: 1.775
- Patent Class: 536.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14903817', '10952496', '10989606', '12820161', '10989607']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6011889955989617
- 35 USC 102 Novelty (BERT): 0.5888955152467341
- Combined Prediction Score: 0.599959647563739
- Mean Citation Score: 279.74787200000003
- Max Citation Score: 564.139
- Similarity Product: 424.53904175150393

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test