PATENT CLAIM ANALYSIS

Application Number: 16178257
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "171000"]

Abstract:
Provided herein is a pharmaceutical composition comprising (i) a phosphodiesterase inhibitor or an adenosine receptor antagonist, (ii) a calcium channel blocker, (iii) a histamine H 1 -receptor agonist, a histamine H 2 -receptor agonist, or a histamine H 3 -receptor antagonist, and (iv) a β 2 -adrenoreceptor agonist; wherein at least one of two or more active pharmaceutical compounds is deuterium enriched. Also provided herein is a pharmaceutical composition comprising at least one of two or more deuterated compounds which increase pharmacokinetic half-life (increasing the duration of action) and reduce side effects by allowing for reduction of the dose levels. A method of use thereof pharmaceutical composition for treating, preventing, or ameliorating a cardiovascular disease.

Claim (Index 1):
The pharmaceutical composition, comprising (i) a phosphodiesterase inhibitor or an adenosine receptor antagonist, (ii) a calcium channel blocker, (iii) a histamine H 1 -receptor agonist, a histamine H 2 -receptor agonist, or a histamine H 3 -receptor antagonist, (iv) a \u03b2 2 -adrenoreceptor agonist; and (v) a pharmaceutically acceptable excipient; wherein at least one compound is deuterium-enriched.

Metadata:
- Claim Count in Document: 45.0
- Percentile: 98.0
- Lexical Diversity: 1.78947
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['11521926', '13438105', '12075107', '12132147', '11077345']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7179075839831535
- 35 USC 102 Novelty (BERT): 0.4899882344658918
- Combined Prediction Score: 0.6951156490314274
- Mean Citation Score: 217.81704
- Max Citation Score: 222.36911
- Similarity Product: 178.0746336614752

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test