PATENT CLAIM ANALYSIS

Application Number: 15991998
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["424", "001490"]

Abstract:
The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin α4. The antibodies can preferentially stain cancer or tumor cells or tissue. The antibodies can be used for detecting cancer, evaluating the efficacy of a cancer therapy, treating cancer, and treating obesity or obesity-related diseases, among other applications.

Claim (Index 63):
A method for detecting the presence of a cancer in a biological sample, the method comprising:\n (a) contacting the biological sample with a monoclonal antibody that specifically binds to an epitope within the LG4-5 modules of the G domain of laminin \u03b14, wherein the antibody comprises three heavy chain CDRs and three light chain CDRs of\n (i) an antibody characterized by a mature heavy chain variable region of SEQ ID NO:16 and mature light chain variable region of SEQ ID NO:17; \n (ii) an antibody characterized by a mature heavy chain variable region of SEQ ID NO:26 and mature light chain variable region of SEQ ID NO:27; \n (iii) an antibody characterized by a mature heavy chain variable region of SEQ ID NO:36 and mature light chain variable region of SEQ ID NO:38; or \n (iv) an antibody characterized by a mature heavy chain variable region of SEQ ID NO:37 and mature light chain variable region of SEQ ID NO:38. \n (b) detecting binding of the antibody to the biological sample; (c) contacting a control sample with the antibody of any one of claims  1 - 48  or  88 - 92 ; (d) detecting binding of the antibody to the control sample; and (e) comparing binding of the antibody to the biological sample with binding of the antibody to the control sample, whereby increased binding of the antibody to the biological sample compared to the control sample indicates the presence of cancer in the biological sample.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 93.0
- Lexical Diversity: 1.47619
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14656619', '15201423', '15201416', '15125570', '15201429']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6615854108325075
- 35 USC 102 Novelty (BERT): 0.6363364238963805
- Combined Prediction Score: 0.6590605121388949
- Mean Citation Score: 401.37045
- Max Citation Score: 611.8948
- Similarity Product: 540.2384538682222

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test