PATENT CLAIM ANALYSIS

Application Number: 15864378
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["530", "412000"]

Abstract:
The present invention is directed to methods for purifying a protein of interest, e.g., an antibody, from a sample comprising the protein of interest and at least one impurity, e.g., an aggregate, by employing a hydrophobic interaction chromatography (HIC) method that allows for binding of both the protein of interest and the at least one impurity under strong binding conditions. The present invention is based, at least in part, on the finding that both flow through and bind-elute techniques can be combined to achieve greater purification and recovery of a protein of interest, e.g., an antibody, under isocratic wash conditions and strong binding conditions.

Claim (Index 17):
The method of  claim 1 , wherein the HIC media either (i) comprises at least one hydrophobic ligand, optionally selected from the group consisting of alkyl-, aryl-ligands, and butyl, hexyl, phenyl, octyl, or polypropylene glycol ligands; and/or (ii) is selected from the group consisting of CaptoPhenyl, Phenyl Sepharose\u2122 6 Fast Flow with low or high substitution, Phenyl Sepharose\u2122 High Performance, Octyl Sepharose\u2122 High Performance, Fractogel\u2122 EMD Propyl, Fractogel\u2122 EMD Phenyl, Macro-Prep\u2122 Methyl, Macro-Prep\u2122 t-Butyl, WP HI-Propyl (C3)\u2122, Toyopearl\u2122 ether, Toyopearl\u2122 phenyl, Toyopearl\u2122 butyl, ToyoScreen PPG, ToyoScreen Phenyl, ToyoScreen Butyl, ToyoScreen Hexyl, HiScreen Butyl FF, HiScreen Octyl FF, and Tosoh Hexyl.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 86.0
- Lexical Diversity: 1.91935
- Patent Class: 530.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14077574', '13831181', '14584492', '15545271', '14584619']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7254312214636104
- 35 USC 102 Novelty (BERT): 0.637585936399401
- Combined Prediction Score: 0.7166466929571894
- Mean Citation Score: 392.83938
- Max Citation Score: 616.52576
- Similarity Product: 472.3197902448082

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test