PATENT CLAIM ANALYSIS

Application Number: 16013619
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["424", "186100"]

Abstract:
The present disclosure provides a method to enhance the production of virus in cultured fibroblasts by supplementing the cells with a TCA cycle intermediate, aketoglutarate, or a derivative thereof, wherein virus production is enhanced compared to the same method canied out in the absence of a-ketoglutarate or the derivative thereof. In view of the art, the method provides an unexpected improvement on methods routinely practiced.

Claim (Index 108):
The method of any one of  claims 14 - 107  wherein the scavenging compound is present at a concentration of at least 1 \u03bcM, at least 2 \u03bcM, at least 3 \u03bcM, at least 4 \u03bcM, at least 5 \u03bcM, at least 6 \u03bcM, at least 7 \u03bcM, at least 8 \u03bcM, at least 9 \u03bcM, at least 10 \u03bcM, at least 15 \u03bcM, at least 20 \u03bcM, at least 25 \u03bcM, at least 30 \u03bcM, at least 35 \u03bcM, at least 40 \u03bcM, at least 45 \u03bcM, at least 50 \u03bcM, at least 55 \u03bcM, at least 60 \u03bcM, at least 65 \u03bcM, at least 70 \u03bcM, at least 75 \u03bcM, at least 80 \u03bcM, at least 85 \u03bcM, at least 90 \u03bcM, at least 95 \u03bcM, at least 100 \u03bcM, at least 110 \u03bcM, at least 120 \u03bcM, at least 130 \u03bcM, at least 140 \u03bcM, at least 150 \u03bcM or more, and wherein the scavenging compound is present at a concentration of 500 \u03bcM or less, or at a concentration that is not toxic to the host cell.

Metadata:
- Claim Count in Document: 25.0
- Percentile: 94.0
- Lexical Diversity: 1.51064
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14112824', '13438616', '14543321', '13055587', '12156517']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7073798815963878
- 35 USC 102 Novelty (BERT): 0.5183343862220576
- Combined Prediction Score: 0.6884753320589548
- Mean Citation Score: 164.851584
- Max Citation Score: 300.48376
- Similarity Product: 209.93016776330472

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test