PATENT CLAIM ANALYSIS

Application Number: 16075932
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-02
Patent Classification: ["514", "394000"]

Abstract:
The present invention is related to diagnostic, treatment and compound screening methods related to dry age-related macular degeneration (dry AM D). In select embodiments, the methods comprise determining expression or activity levels of NAD-dependent deacetylase sirtuin-1 (SI RT-1), AM P-activated protein kinase (AM PK), poly(adenosine diphosphate ribose) poly-merase-2 (PARP2), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-Iα) and/or mRNA levels of RAC-gamma serine/threonine-protein kinase (AKT3). In general, higher levels of PARP2, lower levels of PGC-Iα or AKT3 and/or higher acetylation levels of PGC-Iα in the samples are indicative that the subject or cells from which the samples are obtained are susceptible or are suffering from dry AMD.

Claim (Index 4):
A method of determining if a subject is at risk of developing dry age-related macular degeneration (dry AMD), the method comprising\n a) determining mRNA levels of RAC-gamma serine/threonine-protein kinase (AKT3) in a sample obtained from the subject, b) comparing the determined mRNA levels of AKT3 in the subject with the mRNA levels obtained from subjects determined to define normal mRNA levels of AKT3 to determine if the subject's mRNA levels of AKT3 are altered compared to normal mRNA levels of AKT3, wherein a reduction in the mRNA levels of AKT3 in the sample compared to normal mRNA levels is indicative that the subject is at risk of developing dry AMD.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 96.0
- Lexical Diversity: 1.71053
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12583073', '15485997', '14746221', '10773446', '11660986']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7615408714143466
- 35 USC 102 Novelty (BERT): 0.5090364019991781
- Combined Prediction Score: 0.7362904244728297
- Mean Citation Score: 258.177182
- Max Citation Score: 271.42883
- Similarity Product: 184.5498949031204

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test