PATENT CLAIM ANALYSIS

Application Number: 15749951
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "171000"]

Abstract:
The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent. The matrix forming agent forms a gel at a suitable gelation temperature and rheological properties for use in drug delivery, and in some cases, the gelation temperature and rheological properties are not significantly changed from those of the composition without the permeation enhancer. The invention also provides a matrix forming agent and compositions thereof. Such compositions are particularly useful in the treatment of otitis media. Methods of treatment, methods of delivery, and kits for the compositions described herein are also provided.

Claim (Index 65):
A matrix forming agent or a combination of matrix forming agents, wherein the matrix forming agent or combination of matrix forming agents comprises a polymer of Formula (I\u2032): wherein:\n each occurrence of Y is independently \u2014R 1  or -L2R2; \n each occurrence of R 1  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, or optionally substituted heteroaryl; \n each occurrence of L 2  is independently a bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted alkynylene, optionally substituted heteroalkylene, optionally substituted heteroalkenylene, or optionally substituted heteroalkynylene; \n each occurrence of R 2  is independently optionally substituted acyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, \u2014O b , \u2014N(R b ) 2 , or an oxygen protecting group; \n each occurrence of R 3A  is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteryaryl, optionally substituted acyl, \u2014O b , or \u2014N(R b ) 2 ; \n each occurrence of R b  is independently optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, an oxygen protecting group, or a nitrogen protecting group, or two R b  taken together with the nitrogen to which they are attached form an optionally substituted heterocyclic or optionally substituted heteroaryl ring; \n each of G 1A  and G 2A  is independently hydrogen, halogen, optionally substituted amine, optionally substituted alkyl, optionally substituted aryl, or optionally substituted heteroaryl, optionally substituted acyl, optionally substituted phosphate, or an oxygen protecting group; and \n each of p, q, r, s, and t is independently an integer between 0 and 200, inclusive, wherein the sum of p and t is at least 1, and the sum of q, r, and s is at least 1.

Metadata:
- Claim Count in Document: 43.0
- Percentile: 88.0
- Lexical Diversity: 2.10145
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12993358', '10224173', '11899172', '14795819', '11547898']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7649877714420297
- 35 USC 102 Novelty (BERT): 0.5241207263270776
- Combined Prediction Score: 0.7409010669305345
- Mean Citation Score: 211.810478
- Max Citation Score: 302.94693
- Similarity Product: 181.5625857751876

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test