PATENT CLAIM ANALYSIS

Application Number: 15870014
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-05
Patent Classification: ["548", "101000"]

Abstract:
The present invention relates to intermediates of Formula I and to methods of synthesizing and purifying calicheamicin derivatives.

Claim (Index 129):
A method of purifying a calicheamicin derivative of Formula VI wherein J is R 1  is or CH 3 ; R 2  is or H;\n R 3  is \n or H; R 4  is or H;\n R 5  is \u2014CH 3 , \u2014C 2 H 5 , or \u2014CH(CH 3 ) 2 ; \n X is an iodine or bromine atom; \n R 5\u2032  is a hydrogen or the group RCO, wherein R is hydrogen, branched or unbranched alkyl of 1 to 10 carbon atoms, alkylene of 2 to 10 carbon atoms, aryl of 6 to 11 carbon atoms, a (C 6 -C 11 ) aryl-alkyl (C 1 -C 5 ) group, or a heteroaryl or heteroaryl-alkyl (C 1 -C 5 ) group wherein heteroaryl is defined as 2- or 3-furyl, 2- or 3-thienyl, 2- or 3-(N-methylpyrrolyl), 2-, 3-, or 4-pyridinyl, 2-, 4-, or 5-(N-methylimidazolyl), 2-, 4-, or 5-oxazolyl, 2-, 3-, 5-, or 6-pyrimidinyl, 2-, 3-, 4-, 5-, 6-, 7-, or 8-quinolyl, or 1-, 3-, 4-, 5-, 6-, 7-, or 8-isoquinolyl, all aryl and heteroaryl groups optionally substituted by one or more hydroxy, amino, carboxy, halo, nitro, (C 1 -C 3 ) alkoxy, or thioalkoxy of 1 to 5 carbon atoms; \n R 6  and R 7  are each independently selected from H and \n R 8  and R 9  are each independently selected from hydrogen and straight and branched-chain C 1 -C 8  alkyl, wherein each said alkyl for R 8  and R 9  is independently optionally substituted by \u2014NH 2 , \u2014NHR 11 , \u2014NR 11 R 13 , \u2014OR 11 , \u2014OH, or \u2014SR 11 , wherein each R 11  and each R 13  are independently selected from straight and branched-chain C 1 -C 5  alkyl; r is an integer 0 or 1; G is oxygen or sulfur; Z 1  is H or straight or branched-chain C 1 -C 5  alkyl; Ar is 1,2-, 1,3-, or 1,4-phenylene optionally substituted with one, two or three groups independently selected from straight or branched-chain C 1 -C 6  alkyl, \u2014OR 14 , \u2014SR 14 , halogen, nitro, \u2014COOR 14 , \u2014C(\u2550O)NHR 14 , \u2014O(CH 2 ) n COOR 14 , \u2014S(CH 2 ) n COOR 14 , \u2014O(CH 2 ) n C(\u2550O)NHR 14 , and \u2014S(CH 2 ) n C(\u2550O)NHR 14 , or Ar is a 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, 1,7-, 1,8-, 2,3-, 2,6-, or 2,7-naphthylidene optionally substituted with one, two, three, or four groups independently selected from straight or branched-chain C 1 -C 6  alkyl, \u2014OR 14 , \u2014SR 14 , halogen, nitro, \u2014COOR 14 , \u2014C(\u2550O)NHR 14 , \u2014O(CH 2 ) n COOR 14 , \u2014S(CH 2 ) n COOR 14 , \u2014O(CH 2 ) n C(\u2550O)NHR 14 , and \u2014S(CH 2 ) n C(\u2550O)NHR 14 ; wherein each R 14  is independently selected from (C 1 -C 5 )alkyl and each R 14  is independently optionally substituted with one or two groups selected from \u2014OH, \u2014(C 1 -C 4 )alkyl, and \u2014S(C 1 -C 4 )alkyl; each n is an integer independently selected from 0, 1, 2, 3, 4, and 5; W is selected from \u2014O\u2014, \u2014S\u2014, \u2014C(\u2550O)NH\u2014, \u2014NHC(\u2550O)\u2014, and \u2014NR 15 \u2014, wherein R 15  is a (C 1 -C 5 )alkyl and R 15  is optionally substituted with one or two groups selected from \u2014OH, \u2014(C 1 -C 4 )alkyl, and \u2014S(C 1 -C 4 )alkyl; Y is a straight or branched-chain (C 1 -C 6 )alkylene group or a straight or branched-chain (C 2 -C 6 )alkenylene group; and Z is selected from the group consisting of which method comprises subjecting the calicheamicin derivative of Formula VI to a reversed phase high performance liquid chromatography purification protocol.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 86.0
- Lexical Diversity: 1.1875
- Patent Class: 548.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15030563', '12583237', '14711267', '14286708', '10355125']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8042886148345627
- 35 USC 102 Novelty (BERT): 0.5500326030355497
- Combined Prediction Score: 0.7788630136546614
- Mean Citation Score: 321.8862180000001
- Max Citation Score: 441.5852
- Similarity Product: 313.1457825734853

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test