PATENT CLAIM ANALYSIS

Application Number: 15899721
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["436", "053000"]

Abstract:
Disclosed is a method and apparatus for determining a concentration of a glycopeptide antibiotic containing a phenol moiety such as Vancomycin in a complex sample matrix by extracting the glycopeptide antibiotic from a metered portion of the complex sample matrix by exposing said metered portion to an extraction material having an affinity with the glycopeptide antibiotic; and exposing the extraction material to a metered portion of an eluent for releasing the glycopeptide antibiotic from the extraction material; and by determining a concentration of the glycopeptide antibiotic by adding a Gibbs reagent ( 2,6  dichloroquinone- 4 -chloroimide) to the metered portion of the complex sample matrix or the eluent; activating the Gibbs reagent and, after the reaction between the activated Gibbs reagent and the antibiotic has stabilized; detecting the reaction product of the activated Gibbs reagent and the antibiotic in said eluent; and determining the concentration of the antibiotic in the complex sample matrix from the detected reaction product. A method of designing a personalized drug administration regime using the thus obtained concentration is also disclosed.

Claim (Index 1):
An apparatus for automatically extracting of a glycopeptide antibiotic containing a phenol moiety from a complex sample matrix comprising cellular material, the apparatus comprising:\n a sample reception stage having on output for providing a defined quantity of the complex sample matrix; a mixing stage having a first input in fluidic connection with the output of the 30 sample reception stage, a second input for receiving a lysing agent and an output for providing a mixture of the defined quantity of the complex sample matrix and the lysing agent; a delay stage having an input in fluidic connection with the output of the mixing stage and an output for providing the delayed mixture of the defined quantity of the complex sample matrix and the lysing agent; a filtering stage comprising a sorbent material for mechanically lysing the cellular material, said sorbent material having an affinity for binding of the glycopeptides antibiotic, said filtering stage having an input in fluidic connection with the output of the delay stage; and a controller for controlling the flow rate of the mixture of the defined quantity of the complex sample matrix and the lysing agent through said delay stage, wherein the apparatus further comprises a colorimetric measurement stage in fluid connection with the filtering stage and arranged to determine the colorimetric spectrum of an eluent received from the filtering stage including a reaction product of the glycopeptide antibiotic and the activated Gibbs reagent; and a processor coupled to the colorimetric measurement stage adapted to derive a concentration of the glycopeptide antibiotic in the complex sample matrix from a specific wavelength in the colorimetric spectrum.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 88.0
- Lexical Diversity: 2.52055
- Patent Class: 436.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14768421', '13878820', '13878815', '14236876', '14648203']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5650884533510083
- 35 USC 102 Novelty (BERT): 0.5774058771582626
- Combined Prediction Score: 0.5663201957317338
- Mean Citation Score: 280.48415800000004
- Max Citation Score: 514.65076
- Similarity Product: 405.028952017951

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test