PATENT CLAIM ANALYSIS

Application Number: 15937475
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-08
Patent Classification: ["548", "373100"]

Abstract:
There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.

Claim (Index 1):
A compound with structure of the following formula: or pharmaceutically acceptable salt, ester, solvate, or prodrug thereof; wherein: L 1  is \u2014NR 5 \u2014; L 2  is a bond; L 3  is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, \u2014S\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014O\u2014, \u2014NHSO 2 \u2014, or \u2014NR 5 \u2014; L 4  is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, \u2014S\u2014, \u2014SO\u2014, \u2014SO 2 \u2014, \u2014O\u2014, \u2014NHSO 2 \u2014, or \u2014NR 5 \u2014; R 1  is substituted alkyl, wherein any substituent group of said R 1  substituted alkyl is selected from the group consisting of \u2014OH, \u2014NH 2 , \u2014SH, \u2014CN, \u2014CF 3 , \u2014NO 2 , halogen, \u2014COOH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; R 2  is substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, or substituted or unsubstituted aryl, wherein any substituent group of said R 2  substituted alkyl, substituted heteroalkyl, or substituted aryl is selected from the group consisting of \u2014OH, \u2014NH 2 , \u2014SH, \u2014CN, \u2014CF 3 , \u2014NO 2 , halogen, \u2014COOH, oxo, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted and unsubstituted heteroaryl; R 3  is substituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein when R 3  is substituted heteroaryl, any substituent group of said R 3  heteroaryl is selected from the group consisting of \u2014OH, \u2014NH 2 , \u2014SH, \u2014CN, \u2014CF 3 , \u2014NO 2 , halogen, \u2014COOH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted and unsubstituted heteroaryl; R 4  is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 5  is hydrogen or substituted or unsubstituted alkyl.

Metadata:
- Claim Count in Document: 9.0
- Percentile: 90.0
- Lexical Diversity: 1.60526
- Patent Class: 548.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13630201', '14776612', '15605566', '15811220', '14776641']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8357737805984794
- 35 USC 102 Novelty (BERT): 0.5849859537053584
- Combined Prediction Score: 0.8106949979091673
- Mean Citation Score: 464.241458
- Max Citation Score: 486.57462
- Similarity Product: 463.6566327089524

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test