PATENT CLAIM ANALYSIS

Application Number: 15866060
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-07
Patent Classification: ["435", "032000"]

Abstract:
Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.

Claim (Index 1):
A method for determining a minimum inhibitory concentration of one or more bacteria in a sample comprising the steps of:\n a. preparing a plurality of bacterial suspensions in a plurality of receptacles, b. adding to step a. varying concentrations of an antimicrobial agent, thereby creating a plurality of suspensions comprising a combination of bacteria and antimicrobial agent, c. incubating the plurality of suspensions comprising a combination of bacteria and antimicrobial agent of step b. at a suitable temperature for a suitable period of time, thereby creating a plurality of incubated suspensions comprising a combination of bacteria and antimicrobial agent, d. adding to the suspensions of step c. a single membrane-associated dye, e. illuminating the suspensions of step d. with an incident light at a one or more excitation wavelength, f. measuring intensity of emitted light at two emission wavelengths of each suspension, g. determining the spectral intensity ratios based upon step f. of each suspension, and h. determining the minimum inhibitory concentration based upon step g. by determining the spectral intensity ratio (SIR) as a function of the antimicrobial concentration.

Metadata:
- Claim Count in Document: 14.0
- Percentile: 86.0
- Lexical Diversity: 1.31148
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14382043', '14289745', '13402445', '15318261', '15060703']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5824297073715733
- 35 USC 102 Novelty (BERT): 0.4921816783073636
- Combined Prediction Score: 0.5734049044651524
- Mean Citation Score: 201.985182
- Max Citation Score: 214.2875
- Similarity Product: 144.01428990215064

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test