PATENT CLAIM ANALYSIS

Application Number: 15765232
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["548", "400000"]

Abstract:
Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.

Claim (Index 1):
A compound having the structure of Formula I: or pharmaceutically acceptable salts or solvates thereof, wherein: R 1  is selected from the group consisting of hydrogen, deuterium, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 3 -C 7  cycloalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl; R 2  is selected from the group consisting of hydrogen, deuterium, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 3 -C 7  cycloalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl; R 3  is selected from the group consisting of hydrogen, deuterium, and optionally substituted C 1 -C 6  alkyl, an optionally substituted hydroxyl, an optionally substituted C 1 -C 6  alkoxy, an optionally substituted C 3 -C 7  cycloalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl; R 4  is an optionally substituted C 1 -C 6  alkyl; R 5  is hydrogen, deuterium or an optionally substituted C 1 -C 6  alkyl; R 6  is hydrogen, deuterium or an optionally substituted C 1 -C 6  alkyl; X 1  and X 2  are each independently selected from the group consisting of hydrogen, deuterium, an optionally substituted C 1 -C 6  alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, halogen, \u2014CN, \u2014N 3 , \u2014COOR B , \u2014NR A R B , \u2014OR B , and \u2014SR B , where at least one of X 1  and X 2  is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl, halogen, \u2014CN, \u2014N 3 , \u2014COOR B , \u2014NR A R B , \u2014OR B , and \u2014SR B  when R 5  is methyl; R A  is selected from the group consisting of hydrogen, deuterium, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 3 -C 7  cycloalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl; R B  is selected from the group consisting of hydrogen, deuterium, an optionally substituted C 1 -C 6  alkyl, an optionally substituted C 3 -C 7  cycloalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl; R 7  is an optionally substituted C 1 -C 6  alkyl, an optionally substituted heteroaryl, or \u2014C(\u2550O)R C ; R C  is selected from the group consisting of an optionally substituted C 1 -C 6  alkyl, optionally substituted C 1 -C 6  alkoxy, an optionally substituted C 3 -C 7  cycloalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl, and hydroxyl; and R 8  is hydrogen, deuterium or hydroxyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 90.0
- Lexical Diversity: 1.77778
- Patent Class: 548.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14401318', '14843520', '15581749', '15557703', '13513982']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7975887736464187
- 35 USC 102 Novelty (BERT): 0.5070229046734386
- Combined Prediction Score: 0.7685321867491207
- Mean Citation Score: 295.580128
- Max Citation Score: 303.1212
- Similarity Product: 244.56834042692185

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test