PATENT CLAIM ANALYSIS

Application Number: 15762670
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "218000"]

Abstract:
A series of substituted pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a][1,3,5]-triazine derivatives of formula (I), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.

Claim (Index 1):
A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: wherein X represents N or CH; M represents the residue of an optionally substituted saturated four-, five-, six- or seven-membered monocyclic ring containing one nitrogen atom and 0, 1, 2 or 3 additional heteroatoms independently selected from N, O and S, but containing no more than one O or S atom; or M represents the residue of an optionally substituted saturated or unsaturated 5- to 10-membered fused bicyclic ring system containing one nitrogen atom and 0, 1, 2 or 3 additional heteroatoms independently selected from N, O and S, but containing no more than one O or S atom; or M represents the residue of an optionally substituted saturated 5- to 9-membered bridged bicyclic ring system containing one nitrogen atom and 0, 1, 2 or 3 additional heteroatoms independently selected from N, O and S, but containing no more than one O or S atom; or M represents the residue of an optionally substituted saturated 5- to 9-membered spirocyclic ring system containing one nitrogen atom and 0, 1, 2 or 3 additional heteroatoms independently selected from N, O and S, but containing no more than one O or S atom; R 1  and R 2  independently represent hydrogen, halogen, cyano, nitro, hydroxy, trifluoromethyl, trifluoromethoxy, \u2014OR a , \u2014SR a , \u2014SOR a , \u2014SO 2 R a , \u2014NR b R c , \u2014CH 2 NR b R c , \u2014NR c COR d , \u2014CH 2 NR c COR d , \u2014NR c CO 2 R d , \u2014NHCONR b R c , \u2014NR c SO 2 R e , \u2014N(SO 2 R e ) 2 , \u2014NHSO 2 NR b R c , \u2014COR d , \u2014CO 2 R d , \u2014CONR b R c , \u2014CON(OR a )R b  or \u2014SO 2 NR b R c ; or C 1-6  alkyl, C 3-7  cycloalkyl, C 3-7  cycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, C 3-7  heterocycloalkyl, C 3-7  heterocycloalkyl(C 1-6 )alkyl, C 3-7  heterocycloalkenyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents; R 3  represents hydrogen, halogen, cyano, trifluoromethyl or C 1-6  alkyl; R a  represents hydrogen; or R a  represents C 1-6  alkyl, aryl, aryl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents; R b  and R c  independently represent hydrogen or trifluoromethyl; or C 1-6  alkyl, C 3-7  cycloalkyl, C 3-7  cycloalkyl(C 1-6 )alkyl, aryl, aryl(C 1-6 )alkyl, C 3-7  heterocycloalkyl, C 3-7  heterocycloalkyl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-6 )alkyl, any of which groups may be optionally substituted by one or more substituents; or R b  and R c , when taken together with the nitrogen atom to which they are both attached, represent azetidin-1-yl, pyrrolidin-1-yl, oxazolidin-3-yl, isoxazolidin-2-yl, thiazolidin-3-yl, isothiazolidin-2-yl, piperidin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, piperazin-1-yl, homopiperidin-1-yl, homomorpholin-4-yl or homopiperazin-1-yl, any of which groups may be optionally substituted by one or more substituents; R d  represents hydrogen; or C 1-6  alkyl, C 3-7  cycloalkyl, aryl, C 3-7  heterocycloalkyl or heteroaryl, any of which groups may be optionally substituted by one or more sub stituents; and R e  represents C 1-6  alkyl, aryl or heteroaryl, any of which groups may be optionally substituted by one or more substituents.

Metadata:
- Claim Count in Document: 40.0
- Percentile: 90.0
- Lexical Diversity: 1.38462
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15318422', '15318507', '16060486', '14357340', '13508956']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7932696880633903
- 35 USC 102 Novelty (BERT): 0.548329958125445
- Combined Prediction Score: 0.7687757150695957
- Mean Citation Score: 379.267696
- Max Citation Score: 396.2881
- Similarity Product: 267.8466319199204

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test