PATENT CLAIM ANALYSIS

Application Number: 16024407
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-11
Patent Classification: ["544", "330000"]

Abstract:
Novel, antimitotic heteroaryl amides and pharmaceutically acceptable salts of Formula I where Ar, R 5 , R 6 , R 8 , R 9 , R 11 , X 1 , and X 2  are as defined herein, as compounds for treatment and prevention of cancer and proliferative diseases and disorders.

Claim (Index 1):
A compound or salt of formula III wherein\n X 1  is selected from N and CR 7 ; \n X 2  is selected from N and CR 10 ; \n each of D 1 , D 2 , D 3 , and D 4  is selected from CR 1 , CR 2 , CR 3 , CR 4 , N, O, and S; \n B is C; \n each of R 1 , R 2 , R 3 , and R 4  is independently selected from \u2014H, halogen, substituted or unsubstituted C 1-8  alkyl, substituted or unsubstituted C 3-6  cycloalkyl, substituted or unsubstituted C 2-8  alkenyl, substituted or unsubstituted C 2-8  alkynyl, \u2014CN, \u2014NO 2 , \u2014C(O)R A , \u2014CO 2 R A , \u2014C(O)NR A R B , \u2014OR A , \u2014OC(O)R A , \u2014OC(O)NR A R B , \u2014NR C C(O)R A , \u2014NR C C(O)NR A R B , \u2014NR A R B , \n \u2014NR C CO 2 R A , \u2014NR C S(O) 2 R A , \u2014SR A , \u2014S(O)R A , \u2014S(O) 2 R A , \u2014S(O) 2 NR A R B , substituted or unsubstituted C 6-10  aryl, substituted or unsubstituted 5- to 10-membered heteroaryl, and substituted or unsubstituted 3- to 10-membered heterocyclyl; \n each of R 5 , R 6 , R 7 , R 10 , and R 11  is independently selected from \u2014H, halogen, substituted or unsubstituted C 1-8  alkyl, substituted or unsubstituted C 2-8  alkenyl, substituted or unsubstituted C 2-8  alkynyl, \u2014CN, \u2014NO 2 , \u2014C(O)R A , \n \u2014CO 2 R A , \u2014C(O)NR A R B , \u2014OR A , \u2014OC(O)R A , \u2014OC(O)NR A R B , \u2014NR C C(O)R A , \n \u2014NR C C(O)NR A R B , \u2014NR A R B , \u2014NR C CO 2 R A , \u2014NR C S(O) 2 R A , \u2014SR A , \u2014S(O)R A , \n \u2014S(O) 2 R A , \u2014S(O) 2 NR A R B , substituted or unsubstituted C 6-10  aryl, substituted or unsubstituted 5- to 10-membered heteroaryl, and substituted or unsubstituted 3- to 10-membered heterocyclyl; \n each of R 8  and R 9  is independently selected from \u2014H, halogen, \u2014OR A , \n \u2014NH 2 , \u2014NO 2 , \u2014O(CO)R A , \u2014O(CO)NR A R B , \u2014SH, and \u2014SR A ; \n each of R A , R B , and R C , when present, is independently selected from \u2014H, halogen, substituted or unsubstituted C 1-8  alkyl, substituted or unsubstituted C 3-6  cycloalkyl, substituted or unsubstituted C 2-8  alkenyl, substituted or unsubstituted C 2-8  alkynyl, \u2014CN, \u2550O, \u2014NO 2 , \u2014OR\u2032, \u2014OC(O)R\u2032, \n \u2014CO 2 R\u2032, \u2014C(O)R\u2032, \u2014C(O)NR\u2032R\u2033, \u2014OC(O)NR\u2032R\u2033, \u2014NR\u2032\u2033C(O)R\u2032, \u2014NR\u2032\u2033C(O)NR\u2032R\u2033, \u2014NR\u2032R\u2033, \u2014NR\u2032\u2033CO 2 R\u2032, \u2014SR\u2032, \u2014S(O)R\u2032, \u2014S(O) 2 R\u2032, \u2014S(O) 2 NR\u2032R\u2033, \u2014NR'S(O) 2 R\u2033, substituted or unsubstituted C 6-10  aryl, substituted or unsubstituted 5- to 10-membered heteroaryl and substituted or unsubstituted 3- to 10-membered heterocyclyl; \n R\u2032, R\u2033, and R\u2032\u2033 are each independently selected from \u2014H, unsubstituted C 1-4  alkyl, and substituted or unsubstituted C 3-6  cycloalkyl or R\u2032 and R\u2033 together with the atoms which they substitute form a substituted or unsubstituted 5-, 6-, or 7-membered ring; \n provided that when B and D 1  are N, then D 2  and D 4  cannot be C-pyridin-3-yl or C-trifluoromethyl.

Metadata:
- Claim Count in Document: 19.0
- Percentile: 94.0
- Lexical Diversity: 1.52778
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15120470', '15518541', '15380836', '15304947', '15737535']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.797490954219587
- 35 USC 102 Novelty (BERT): 0.5312610699635615
- Combined Prediction Score: 0.7708679657939844
- Mean Citation Score: 317.320912
- Max Citation Score: 369.75244
- Similarity Product: 353.1653876307296

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test