PATENT CLAIM ANALYSIS

Application Number: 15945285
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["549", "200000"]

Abstract:
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.

Claim (Index 41):
A compound of formula (I)\n A 1 -X 1 \u2014X 2 -A 2 \u2003\u2003(I) wherein:\n A 1  is a carboxylic acid group, a carboxylate anion group, or a carboxylate ester group of the formula \u2014COOR a , wherein R a  is an alkyl group or an alkoxylate group; \n A 2  is a cytotoxic drug moiety, which has a molecular weight of no more than 1600 Da; \n X 1  is C 12-22  alkylene or C 12-22  alkenylene; and \n X 2  is a direct bond, or an organic group that comprises one or more moieties selected from the group consisting of: \u2014C(\u2550O)\u2014, \u2014O\u2014C(\u2550O)\u2014, \u2014NH\u2014C(\u2550O)\u2014, one or more units formed from a alkylene glycols, one or more units formed from alkanol amines, and one or more units formed from amino acids; \n wherein when \u2014X 2 \u2014X 1 -A 1  connects to an oxygen atom or an NH group on the cytotoxic drug moiety, then \u2014X 2 \u2014X 1 -A 1  is selected from the group consisting of: \u2014C(\u2550O)\u2014(CH 2 ) n1 \u2014C(\u2550O)\u2014OH; \u2014C(\u2550O)\u2014(CH 2 ) n1 \u2014C(\u2550O)\u2014OCH 3 ; \u2014C(\u2550O)\u2014(C 1-6  alkylene)-C(\u2550O)\u2014O\u2014(CH 2 ) n2 \u2014C(\u2550O)\u2014OH; \u2014C(\u2550O)\u2014(C 1-6  alkylene)-N H\u2014C(\u2550O)\u2014(CH 2 ) n1 \u2014C(\u2550O)\u2014OH; \u2014C(\u2550O)\u2014(C 1-6  alkylene)-C(\u2550O)\u2014O\u2014[(CH 2 ) 2 \u2014O\u2014] n3 (CH 2 ) n2 \u2014C(\u2550O)\u2014OH; and \u2014C(\u2550O)\u2014NH\u2014(CH 2 ) n2 \u2014C(\u2550O)\u2014OH; wherein n1 is an integer 12 to 24, n2 is an integer from 13 to 25, and n3 is an integer from 1 to 25.

Metadata:
- Claim Count in Document: 152.0
- Percentile: 91.0
- Lexical Diversity: 2.06
- Patent Class: 549.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15466819', '15737247', '14298952', '11978122', '15335164']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7306948655719242
- 35 USC 102 Novelty (BERT): 0.5354500466861661
- Combined Prediction Score: 0.7111703836833485
- Mean Citation Score: 224.077398
- Max Citation Score: 372.22952
- Similarity Product: 320.41651237808225

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test