PATENT CLAIM ANALYSIS

Application Number: 15751495
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["514", "184000"]

Abstract:
Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal coordinated by a macrocycle comprising the pentaaza 15-membered macrocyclic ring corresponding to Formula A and two axial ligands having the formula —OC(O)X 1 . each of the two axial ligands has the formula —OC(═O)X 1  wherein each X 1  is independently substituted or unsubstituted phenyl or —C(—X 2 )(—X 3 )(—X 4 ); each X 2  is independently substituted or unsubstituted phenyl, or substituted or unsubstituted alkyl; each X 3  is independently hydrogen, hydroxyl, alkyl, amino, —X 5 C(═O)R 13  where X 5  is NH or O, and R 13  is C 1 -C 18  alkyl, substituted or unsubstituted aryl or C 1 -C 18  aralkyl, or —OR 14 , where R 14  is C 1 -C 18  alkyl, substituted or unsubstituted aryl or C 1 -C 18  aralkyl, or together with X 4  is (═O); and each X 4  is independently hydrogen or together with X 3  is (═O).

Claim (Index 1):
A pentaaza macrocyclic ring complex of Formula (I): wherein M is a transition metal (e.g., Mn 2+ , Mn 3+ , Mn 4+ , Mn 6+ , Mn 7+ , Fe 2+ , Fe 3+ , Fe 4+ , Fe 6+ , Ni 2+ , Ni 3+ , Cu 1+ , Cu 2+ , V 2+ , V 3+ , V 4+ , or V 5+ ); R 1A , R 1B , R 2A , R 2B , R 3A , R 3B , R 4A , R 4B , R 5A , R 5B , R 6A , R 6B , R 7A , R 7B , R 8A , R 8B , R 9A , R 9B , R 10A , and R 10B  are independently:\n (i) hydrogen; \n (ii) a moiety independently selected from the group consisting of alkenyl, alkenylcycloalkenyl, alkenylcycloalkyl, alkyl, alkylcycloalkenyl, alkylcycloalkyl, alkynyl, aralkyl, aryl, cycloalkenyl, cycloalkyl, cycloalkylalkyl, cycloalkylcycloalkyl, cycloalkenylalkyl, heterocyclyl, and aralkyl radicals and radicals attached to the \u03b1-carbon of amino acids (i.e., \u03b1-amino acids); or \n (iii) a moiety independently selected from the group consisting of \u2014OR 11 , \u2014NR 11 R 12 , \u2014COR 11 , \u2014CO 2 R 11 , \u2014CONR 11 R 12 , \u2014SR 11 , \u2014SOR 11 , \u2014SO 2 R 11 , \u2014SO 2 NR 11 R 12 , \u2014N(OR 11 )(R 12 ), \u2014P(\u2550O)(OR 11 )(OR 12 ), \u2014P(O)(OR 11 )(R 12 ), \u2014OP(\u2550O)(OR 11 )(OR 12 ), and substituents attached to the \u03b1-carbon of amino acids (i.e., \u03b1-amino acids), wherein R 11  and R 12  are independently hydrogen or alkyl; \n (iv) a member of a substituted or unsubstituted, saturated, partially saturated, or unsaturated cycle or heterocycle containing 3 to 20 carbon ring atoms comprising\n (a) R 1A  or R 1B  and R 2A  or R 2B ; R 3A  or R 3B  and R 4A  or R 4B ; R 5A  or R 5B  and R 6A  or R 6B ; R 7A  or R 7B  and R 8A  or R 8B ; or R 9A  or R 9B  and R 10A  or R 10B  together with the carbon atoms to which they are respectively attached; \n (b) R 10A  or R 10B  and R 1A  or R 1B ; R 2A  or R 2B  and R 3A  or R 3B ; R 4A  or R 4B  and R 5A  or R 5B ; R 6A  or R 6B  and R 7A  or R 7B ; or R 8A  or R 8B  and R 9A  or R 9B  together with the carbon atoms to which they are respectively attached; or \n (c) R 1A  and R 1B ; R 2A  and R 2B ; R 3A  and R 3B ; R 4A  and R 4B ; R 5A  and R 5B ; R 6A  and R 6B ; R 7A  and R 7B ; R 8A  and R 8B ; R 9A  and R 9B ; or R 10A  and R 10B  together with the carbon atoms to which they are respectively attached; or \n \n (v) a combination of any of (i) through (iv) above; \n each X 1  is independently substituted or unsubstituted phenyl or \u2014C(\u2014X 2 )(\u2014X 3 )(\u2014X 4 ); each X 2  is independently substituted or unsubstituted phenyl, methyl, ethyl or propyl; each X 3  is independently hydrogen, hydroxyl, methyl, ethyl, propyl, amino, \u2014X 5 C(\u2550O)R 13  where X 5  is NH or O, and R 13  is C 1 -C 18  alkyl, substituted or unsubstituted aryl or C 1 -C 18  aralkyl, or \u2014OR 14 , where R 14  is C 1 -C 18  alkyl, substituted or unsubstituted aryl or C 1 -C 18  aralkyl, or together with X 4  is (\u2550O); each X 4  is independently hydrogen or together with X 3  is (\u2550O); and\n the bonds between the transition metal M and the macrocyclic nitrogen atoms and the bonds between the transition metal M and the oxygen atoms of the axial ligands \u2014OC(O)X 1  are coordinate covalent bonds.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 88.0
- Lexical Diversity: 2.7013
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15246830', '15246788', '15301084', '11871848', '14302082']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7702456311119295
- 35 USC 102 Novelty (BERT): 0.613826709469317
- Combined Prediction Score: 0.7546037389476683
- Mean Citation Score: 462.228354
- Max Citation Score: 768.2074
- Similarity Product: 458.2154139416456

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test