PATENT CLAIM ANALYSIS

Application Number: 15747850
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-08
Patent Classification: ["514", "254030"]

Abstract:
The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.

Claim (Index 2):
The 1,3,4-oxadiazole sulfamide derivative compound represented by formula I, stereoisomer thereof or pharmaceutically acceptable salt thereof according to  claim 1 , wherein L 1  or L 3  are each independently \u2014(C 0  alkyl)-;\n L 2  is \u2014(C 1  alkyl)-; Z 1  to Z 4  are each independently N or CR Z , wherein R Z  is \u2014H or \u2014X; R 1  is \u2014CX 2 H or \u2014CX 3 ; R 2  is wherein Y is \u2014N\u2014, \u2014O\u2014 or \u2014S(\u2550O) 2 \u2014, a to d are each independently an integer of 1 or 2, Ra to Rd are each independently \u2014H or \u2014(C 1 -C 4  alkyl), when Y is \u2014N\u2014, R 6  and R 7  are each independently \u2014H, \u2014(C 1 -C 4  alkyl), \u2014C(\u2550O)\u2014(C 1 -C 4  alkyl), \u2014S(\u2550O) 2 \u2014(C 1 -C 4  alkyl), \u2014(C 3 -C 7  cycloalkyl) or \u2014(C 2 -C 6  heterocycloalkyl), wherein at least one H of \u2014(C 1 -C 4  alkyl) may be substituted with \u2014X or \u2014OH, and \u2014(C 2 -C 6  heterocycloalkyl) may contain an N, O or S atom, and when Y is \u2014O\u2014 or \u2014S(\u2550O) 2 \u2014, R 6  and R 7  are null, R 8  and R 9  are each independently \u2014H, \u2014(C 1 -C 4  alkyl) or \u2014(C 1 -C 4  alkyl)-(C 2 -C 6  heterocycloalkyl), wherein at least one H of the \u2014(C 1 -C 4  alkyl)-(C 2 -C 6  heterocycloalkyl) may be substituted with \u2014(C 1 -C 4  alkyl), \u2014C(\u2550O)\u2014(C 1 -C 4  alkyl), \u2014S(\u2550O) 2 \u2014(C 1 -C 4  alkyl) or \u2014(C 2 -C 6  heterocycloalkyl); R 3  is -aryl or -heteroaryl, wherein at least one H of the -aryl or -heteroaryl may be substituted with \u2014X; and X is F, Cl, Br or I.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 86.0
- Lexical Diversity: 1.98734
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15747952', '15748081', '15763972', '11252232', '13522044']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8040776135547094
- 35 USC 102 Novelty (BERT): 0.5775862111153773
- Combined Prediction Score: 0.7814284733107763
- Mean Citation Score: 389.701144
- Max Citation Score: 467.68665
- Similarity Product: 400.6853019959808

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test