PATENT CLAIM ANALYSIS

Application Number: 16046047
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["435", "006100"]

Abstract:
The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.

Claim (Index 73):
A method of determining the presence or absence of a fetal aneuploidy using a maternal blood sample comprising a mixture of fetal and maternal genomic nucleic acids, the method comprising:\n a. obtaining a mixture of fetal and maternal genomic nucleic acids from a maternal blood sample; b. hybridizing genomic nucleic acids with two or more oligonucleotides, wherein each oligonucleotide comprises a region of complementarity with a target region on the genomic nucleic acids and comprises a universal polymerase chain reaction (PCR) primer site to produce hybridization products; c. processing the hybridization products to provide a template for amplification; d. amplifying the amplification products using universal primers labeled with a unique label for each target region to produce single-stranded, labeled nucleic acids; e. hybridizing the single-stranded, labeled nucleic acids to complementary nucleic acids on an array or bead; f. detecting labels on the array or beads and analyzing the labels to determine genotypes of the nucleic acids; and g. generating a report on the presence or absence of aneuploidy in the maternal blood sample based on the genotype analysis.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 95.0
- Lexical Diversity: 1.55814
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14705239', '11763245', '13835926', '13837974', '12230628']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7670269526508336
- 35 USC 102 Novelty (BERT): 0.6571223195323673
- Combined Prediction Score: 0.756036489338987
- Mean Citation Score: 537.6750679999999
- Max Citation Score: 631.3265
- Similarity Product: 506.689156229943

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test