PATENT CLAIM ANALYSIS

Application Number: 16114463
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-07
Patent Classification: ["435", "007210"]

Abstract:
Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.

Claim (Index 19):
An isolated polypeptide selected from the group consisting of:\n (i) a G protein-coupled receptor polypeptide active in taste signaling encoded by a nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs 1,3,5, and 7; (ii) a G protein-coupled receptor polypeptide active in taste signaling comprising an amino acid sequence selected from the group consisting of SEQ ID NOs 2, 4, and 6; (iii) a G protein-coupled receptor polypeptide active in taste signaling encoded by a nucleic acid molecule comprising a nucleic acid sequence having at least about 50% identify to a nucleic acid sequence selected from the group consisting of SEQ ID NOs 1,3,5, and 7; (iv) a G protein-coupled receptor polypeptide active in taste signaling comprising an amino acid sequence that is at least about 40% identical to an amino acid sequence selected from the group consisting of SEQ ID NOs 2, 4, and 6; (v) a variant of a G protein-coupled receptor polypeptide active in taste signaling encoded by a nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs 1, 3, 5, and 7, wherein said variant protein contains at least one conservative substitution relative to the G protein-coupled receptor encoded by said nucleotide sequence; and (vi) a variant of a G protein-coupled receptor polypeptide active in taste signaling comprising an amino acid sequence selected from the group consisting of SEQ ID NOs 2, 4, and 6, containing at least one conservative substitution.

Metadata:
- Claim Count in Document: 27.0
- Percentile: 96.0
- Lexical Diversity: 1.74194
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15264785', '12185392', '09897427', '13016887', '13357110']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6942808315691669
- 35 USC 102 Novelty (BERT): 0.5969367821972341
- Combined Prediction Score: 0.6845464266319736
- Mean Citation Score: 536.3366219999998
- Max Citation Score: 582.6402
- Similarity Product: 436.54535466184615

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test