PATENT CLAIM ANALYSIS

Application Number: 15971017
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["544", "183000"]

Abstract:
This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Claim (Index 1):
A compound of Formula (IIg1) or Formula (IIg2): or a pharmaceutically acceptable salt thereof, wherein: R 1  is Cy A3 -R A ; R A  is H, C 1-6  alkyl, C 1-6  haloalkyl, halo, C 3-6  cycloalkyl, CN, NO 2 , OR a1 , SR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 , OC(O)R b1 , OC(O)NR c1 R d1 , NR c1 R d1 , NR c1 OR d1 , NR c1 C(O)R b1 , NR c1 C(O)OR a1 , NR c1 C(O)NR c1 R d1 , C(NR e1 )R b1 , C(\u2550NR e1 )NR c1 R d1 , NR c1 C(\u2550NR e1 )NR c1 R d1 , NR c1 S(O)R b1 , NR c1 S(O) 2 R b1 , NR c1 S(O) 2 NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O) 2 R b1 , or S(O) 2 NR c1 R d1 ; wherein said C 1-6  alkyl or C 1-6  haloalkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from R 11 ; Cy A3  is piperidinyl optionally substituted with 1, 2, 3 or 4 substituents independently selected from R A3 ; each R A3  is independently selected from OH, NO 2 , CN, halo, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, cyano-C 1-3  alkyl, HO\u2014C 1-3  alkyl, H 2 N\u2014C 1-3  alkyl, amino, C 1-6  alkylamino, di(C 1-6  alkyl)amino, thio, C 1-6  alkylthio, C 1-6  alkylsulfinyl, C 1-6  alkylsulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, carboxy, C 1-6  alkylcarbonyl, C 1-6  alkoxycarbonyl, C 1-6  alkylcarbonylamino, C 1-6  alkylsulfonylamino, aminosulfonyl, C 1-6  alkylaminosulfonyl, di(C 1-6  alkyl)aminosulfonyl, aminosulfonylamino, C 1-6  alkylaminosulfonylamino, di(C 1-6  alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6  alkylaminocarbonylamino, and di(C 1-6  alkyl)aminocarbonylamino; each R B  is independently selected from halo, C 1-6  alkyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, CN, NO 2 , OR a2 , SR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 , OC(O)R b2 , OC(O)NR c2 R d2 , NR c2 R d2 , NR c2 OR d2 , NR c2 C(O)R b2 , NR c2 C(O)OR a2 , NR c2 C(O)NR c2 R d2  NR c2 S(O)R b2 , NR c2 S(O) 2 R b2 , NR c2 S(O) 2 NR c2 R d2  S(O)R b2 , S(O)NR c2 R d2 , S(O) 2 R b2 , and S(O) 2 NR c2 R d2 ; wherein said C 1-6  alkyl, C 2-6  alkynyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 12 ; each R 11  is independently selected from CN, NO 2 , OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , OC(O)R b3 , OC(O)NR c3 R d3 , NR c3 R d3  NR c3 OR d3 , NR c3 C(O)R b3  NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R d3 , NR c3 S(O)R b3 , NR c3 S(O) 2 R b3 , NR c3 S(O) 2 NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O) 2 R b3 , and S(O) 2 NR c3 R d3 ; each R 12  is independently selected from halo, CN, NO 2 , C 1-6  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , OC(O)R b4 , OC(O)NR c4 R d4 , NR c4 R d4 , NR c4 OR d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R d4 , NR c4 S(O)R b4 , NR c4 S(O) 2 R b4 , NR c4 S(O) 2 NR c4 R d4  S(O)R b4 , S(O)NR c4 R d4 , S(O) 2 R b4 , and S(O) 2 NR c4 R d4 ; wherein said C 1-6  alkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; R a1 , R c1  and R d1  are each independently selected from H, C 1-6  alkyl, and C 1-6  haloalkyl; wherein said C 1-6  alkyl is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; or alternatively, R c1  and R d1  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R g ; R b1  is selected from C 1-6  alkyl and C 1-6  haloalkyl, each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; R e1  is selected from H, CN, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkylthio, C 1-6  alkylsulfonyl, C 1-6  alkylcarbonyl, C 1-6  alkylaminosulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, aminosulfonyl, C 1-6  alkylaminosulfonyl, and di(C 1-6  alkyl)aminosulfonyl; each R a2 , R c2 , and R d2  is independently selected from H, C 1-6  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl; wherein said C 1-6  alkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 12 ; or alternatively, any R c2  and R d2  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R 12 ; each R b2  is independently selected from C 1-6  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl, each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R 12 ; each R a3 , R c3  and R d3  is independently selected from H, C 1-6  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-6  cycloalkyl-C 1-4  alkylene, phenyl-C 1-4  alkylene, 5-6 membered heteroaryl-C 1-4  alkylene, and 4-7 membered heterocycloalkyl-C 1-4  alkylene; wherein said C 1-6  alkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-6  cycloalkyl-C 1-4  alkylene, phenyl-C 1-4  alkylene, 5-6 membered heteroaryl-C 1-4  alkylene, and 4-7 membered heterocycloalkyl-C 1-4  alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; or alternatively, any R c3  and R d3  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R g ; each R b3  is independently selected from C 1-6  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-6  cycloalkyl-C 1-4  alkylene, phenyl-C 1-4  alkylene, 5-6 membered heteroaryl-C 1-4  alkylene, and 4-7 membered heterocycloalkyl-C 1-4  alkylene, each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; each R a4 , R c4  and R d4 , is independently selected from H, C 1-6  alkyl, and C 1-6  haloalkyl; wherein said C 1-6  alkyl is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; or alternatively, any R c4  and R d4  attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R g ; each R b4  is independently selected from C 1-6  alkyl and C 1-6  haloalkyl, each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R g ; and each R g  is independently selected from OH, NO 2 , CN, halo, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, cyano-C 1-3  alkyl, HO\u2014C 1-3  alkyl, H 2 N\u2014C 1-3  alkyl, amino, C 1-6  alkylamino, di(C 1-6  alkyl)amino, thio, C 1-6  alkylthio, C 1-6  alkylsulfinyl, C 1-6  alkylsulfonyl, carbamyl, C 1-6  alkylcarbamyl, di(C 1-6  alkyl)carbamyl, carboxy, C 1-6  alkylcarbonyl, C 1-6  alkoxycarbonyl, C 1-6  alkylcarbonylamino, C 1-6  alkylsulfonylamino, aminosulfonyl, C 1-6  alkylaminosulfonyl, di(C 1-6  alkyl)aminosulfonyl, aminosulfonylamino, C 1-6  alkylaminosulfonylamino, di(C 1-6  alkyl)aminosulfonylamino, aminocarbonylamino, C 1-6  alkylaminocarbonylamino, and di(C 1 -6 alkyl)aminocarbonylamino.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.13793
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15469975', '15234690', '15624850', '15247499', '15151259']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8406688196293539
- 35 USC 102 Novelty (BERT): 0.6398455470068005
- Combined Prediction Score: 0.8205864923670987
- Mean Citation Score: 531.0717219999998
- Max Citation Score: 638.51373
- Similarity Product: 577.0798864489602

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test