PATENT CLAIM ANALYSIS

Application Number: 15983519
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-09
Patent Classification: ["514", "210200"]

Abstract:
This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

Claim (Index 21):
A compound represented by the Formula IV: or a pharmaceutically acceptable salt, a prodrug, or a salt of a prodrug, wherein R 1  is represented by the formula: wherein is a monocyclic aryl or heteroaryl group;\n each A is independently C 1-8  alkoxy,\n halogen, \n fluoro substituted C 1 -C 3  alkoxy, or \n fluoro substituted C 1 -C 3  alkyl; \n \n n is 1 or 2; \n R 2  is optionally substituted C 3-8  alkyl, C 1-8  alkyl (C 3-8  cycloalkyl), C 3-8  cycloalkyl, or heteroaryl; \n R 3  is absent; \n R 4  is optionally substituted C 1-8  alkyl, C 2-8  alkenyl, C 3-8  cycloalkyl, C 1-8  alkyl(aryl), C 1-8  alkyl(C 3-8  cycloalkyl), C 1-8  alkyl(heteroaryl), or (CH 2 ) x (NR 7 R 8 ; \n R 5  is optionally substituted adamantanyl, aryl, C 1-8  alkyl, C 1-8  alkyl alcohol, C 1-8  alkyl amino, C 1-8  alkyl amido, C 2-8  alkyl(aryl), C 1-8  alkyl(C 3-8  cycloalkyl), C 1-8  alkyl(C 3-8  cycloalkyl)-CO 2 R 7 , C 1-8  alkyl(guanidinyl), C 1-8  alkyl(heteroaryl), C 1-8  alkyl(tetrazol-5-one), C 2-4  alkyl(heterocycloalkyl), C 1-8  alkyl(thioether), C 1-8  alkyl(thiol), C 2-8  alkenyl, C 2-8  alkenyl(aryl), C 2-8  alkenyl(heteroaryl), C 3-8  alkynyl, C 3-8  cycloalkyl, C 3-8  cycloalkyl-CO 2 R 7 , (CH 2 ) x NR 7 R 8 , (CH 2 ) x OR 7 , (CH 2 ) x NR 9 COR 7 , (CH 2 ) x NR 9 SO 2 R 7 , (CH 2 ) x NR 9 CO 2 R 7 , (CH 2 ) x NHCOR 7 , (CH 2 ) x NHSO 2 R 7 , (CH 2 ) x NHCO 2 R 7 , (CH 2 ) x CONR 7 R 8 , (CH 2 ) x CONR 7 (CH 2 ) y CO 2 R 9 , (CH 2 ) x CONR 7 (CH 2 ) y CONR 7 R 8 , (CH 2 ) x CONR 7 (CH 2 ) y R 9 , (CH 2 ) x COR 7 , (CH 2 ) x CO 2 R 7 , (CH 2 ) x SO 2 NR 7 (CH 2 ) y R 9 , CHR 7 COR 9 , CHR 7 CONHCHR 8 COR 9 , CONR 7 R 8 , CONR 7 (CH 2 ) x CO 2 R 8 , CONR 7 CHR 8 CO 2 R 9 , CO 2 R 9 , NHCO 2 R 7 , or (CH 2 ) x  SO 2 NR 7 R 8 ; \n R 6  is H; or \n R 4  and R 5  together make a 4-8 member ring which may be substituted with one or more heteroatoms; or \n R 4  and R 5  together make a 5-8 member nitrogen-containing ring with one or more carbonyl groups; \n R 7  and R 5  each are independently H, C 1-8  alkoxy, aryl, C 1-8  alkyl, C 1-8  alkyl alcohol, C 1-8  alkyl amino, C 1-8  alkyl amido, C 1-8  alkyl(aryl), C 1-8  alkyl (C 3-8  cycloalkyl), C 1-8  alkyl tetrazol-5-one, C 1-8  alkyl guanidinyl, C 1-8  alkyl heteroaryl, C 1-8  alkyl thioether, C 1-8  alkyl thiol, C 2-8  alkenyl, C 3-8  alkynyl, C 3-8  cycloalkyl, (CH 2 ) x CONHR 9 , (CH 2 ) x COR 9 , (CH 2 ) x CO 2 R 9 , or heteroaryl; or \n R 7  and R 8  together make a 3-9 member ring which may contain one or more heteroatoms; or R 7  and R 5  together make a 5-8 member nitrogen-containing ring with one or more carbonyl groups; \n R 9  is H, C 1-8  alkoxy, C 1-8  alkyl, C 1-8  alkyl(aryl), C 3-8  cycloalkyl, aryl, heteroaryl, or hydroxyl; \n each x is independently 0, 1, 2, 3, 4, 5, 6, 7, or 8; and \n each y is independently 1, 2, 3, 4, 5, 6, 7, or 8; and \n Z is O.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 93.0
- Lexical Diversity: 1.11765
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15374386', '15023510', '10475585', '15418274', '14620721']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8035217475235473
- 35 USC 102 Novelty (BERT): 0.6104234786078584
- Combined Prediction Score: 0.7842119206319785
- Mean Citation Score: 403.533264
- Max Citation Score: 560.4848
- Similarity Product: 490.3261155876159

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test