PATENT CLAIM ANALYSIS

Application Number: 15753319
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["424", "094100"]

Abstract:
Described herein are compounds and methods for tethering proteins. For example, dimers of Protein X listed in Table 1 are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization and can be used to treat neurodegenerative diseases (such as, for example, Parkinson's Disease, ALS, Alzheimer's Disease, Huntington's Disease, Epilepsy, Frontotemporal Dementia, and/or DMD), cancer, autoimmune disease, and/or Celiac disease.

Claim (Index 12):
A method of treating or preventing Disease Y, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I or a compound of Formula II, wherein the compound of Formula I is wherein Y is S, S\u2550O, or S(\u2550O) 2 ; n is 0, 1, 2, 3, or 4; and R is independently selected from the group consisting of \u2014H, \u2014OH, \u2014NH 2 , \u2014NHR\u2032, \u2014N(R\u2032) 2 , alkyl, \u2014OMs, \u2014OTs, \u2014OTf, and \u2014CO 2 H; or any two geminal R groups, taken together, form an imine; or any two vicinal R groups, taken together, form a ring; wherein any alkyl or imine may be substituted with a carbamide, a carboxylate, or a hydroxyl; and R\u2032 is alkyl or aryl; and the compound of Formula II is wherein R\u2033 is \u2014H, alkyl, or aryl, or both R\u2033, taken together, form a ring; wherein any alkyl, aryl, or ring may be substituted with \u2014OH, alkyl, or halo, wherein Disease Y is a neurodegenerative disease (such as, for example, Parkinson's Disease, ALS, Alzheimer's Disease, Huntington's Disease, Epilepsy, Frontotemporal Dementia, and/or DMD), cancer, autoimmune disease, Celiac disease, and/or any of the Disease Y listed in Table 1.

Metadata:
- Claim Count in Document: 12.0
- Percentile: 88.0
- Lexical Diversity: 1.52857
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14440978', '15219807', '14236041', '15827497', '11290735']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6864418744698627
- 35 USC 102 Novelty (BERT): 0.5584618985179803
- Combined Prediction Score: 0.6736438768746744
- Mean Citation Score: 302.579392
- Max Citation Score: 457.756
- Similarity Product: 282.1701312308312

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test