PATENT CLAIM ANALYSIS

Application Number: 15890374
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["424", "001110"]

Abstract:
The present disclosure provides methods of treating a biological tissue using a proton beam. A method includes the steps of: irradiating a proton beam to a biological tissue containing a reactant. The reactant includes a composite. The composite reacts with at least one proton from the proton beam and releases at least one α particle or γ rays. The α particle or γ rays reacts with the biological tissue. Another method includes the steps of: providing a reactant, the reactant comprising a composite; introducing the reactant into a biological tissue, the reactant being distributed in the biological tissue; and irradiating the biological tissue with the proton beam. The composite reacts with at least one proton from the proton beam to release at least one α particle or γ rays, and the α particle or the γ rays reacts with the biological tissue.

Claim (Index 3):
The method of treating biological tissues using a proton beam according to  claim 2 , wherein the composite is selected from a group consisting of (L)-4-dihydroxy-borylphenylalanine (BPA), sodium mercaptoun decahydro-closo-dodecaborate (BSH), carbohydrate derivatives of BSH, sodium salt of closo-B10H102-(GB-10), \u03b2-5-o-carboranyl-2V-deoxyuridine (D-CDU), 3-(dihydroxypropyl-carboranyl-pentyl) thymidine derivative (N5-2OH), boron-containing porphyrins (H2DCP), dequalinium derivatives (DEQ-B), derivatives of trimethoxyindoles, aziridines, derivatives of acridines, phenanthridines, carboranyl polyamines, Pt(II)-amine complexes, dibenzimidazoles, tribenzimidazoles, glucose molecules, mannose molecules, ribose molecules, gulose molecules, fucose molecules, galactose molecules, maltose molecules, lactose molecules, phosphates, phosphonates, phenylureas, thioureas, nitroimidazoles, amines, benzamides, isocyanates, nicotinamides, or azulenes.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 88.0
- Lexical Diversity: 3.18367
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14488293', '13663212', '13658843', '13311025', '11885707']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.689526008666647
- 35 USC 102 Novelty (BERT): 0.5447677897560255
- Combined Prediction Score: 0.6750501867755849
- Mean Citation Score: 167.5734188
- Max Citation Score: 390.17535
- Similarity Product: 374.485186487031

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test