PATENT CLAIM ANALYSIS

Application Number: 16020457
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-12
Patent Classification: ["514", "635000"]

Abstract:
Provided herein are methods for treating subjects having conditions related to adrenocortical activity and/or excessive steroid production. In particular, provided herein are methods for treating subjects having conditions related to adrenocortical activity and/or excessive steroid production through administration of at least one of the following agents: 1) an agent capable of inhibiting cholesterol efflux related to ABCA1 and/or ABCG1; 2) an agent capable of inhibiting MDR1 related cortisol secretion and/or MDR1 P-glycoprotein multiple drug transporter activity; and 3) an agent capable of inhibiting mitochondrial activity.

Claim (Index 2):
The method of  claim 1 ,\n wherein the agent capable of inhibiting cholesterol efflux related to ABCA1 and/or ABCG1 is selected from Valspodar, Glyburide, Cyclosporine A, wherein the agent capable of inhibiting MDR1 related cortisol secretion and/or MDR1 P-glycoprotein multiple drug transporter activity is selected from Tariquidar, MK-571 (CAS 115103-85-0), Niguldipine hydrochloride (CAS 113317-61-6), Matairesinol (CAS 580-72-3), Reversin 121 (C 34 H 47 N 3 O 9 ), Elacridar (CAS 143664-11-3), Pyrimethamine (C 12 H 13 ClN 4 ), Pyrimethamine Biotin (C 27 H 39 N 7 O 3 S), Pyrimethamine-d3 (C 12 H 10 D 3 ClN 4 ), 8-isopentenylnaringenin (CAS 68682-02-0), JS-2190 (Boc-Glu(OBzl)-N,N\u2032-dicyclohexylurea, C 30 H 45 N 3 O 6 ), P-Glycoprotein Inhibitor C-4 (C 23 H 18 C1N0 4 ), PGP-4008 (CAS 365565-02-2), Sipholenol A (CAS 365565-02-2), Reversan (CAS 313397-13-6), CP 100356 hydrochloride (CAS 142716-85-6), PSC 833 (CAS121584-18-7), Zosuquidar trihydrochloride (CAS 167465-36-3), and Vismodegib (CAS 879085-55-9), wherein the agent capable of inhibiting mitochondrial activity is selected from rhodamine-123, MKT-077, decoquinate, isoniazid, suramin, erythrosine, toltrazuril, enilconazole, and metformin.

Metadata:
- Claim Count in Document: 33.0
- Percentile: 94.0
- Lexical Diversity: 1.74074
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13802047', '15170682', '14798237', '14894281', '14148241']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7863186732845895
- 35 USC 102 Novelty (BERT): 0.5252906258559615
- Combined Prediction Score: 0.7602158685417267
- Mean Citation Score: 276.233942
- Max Citation Score: 313.12173
- Similarity Product: 189.98008103257305

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test