PATENT CLAIM ANALYSIS

Application Number: 16064084
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["549", "060000"]

Abstract:
The present invention relates to an improved crystallization procedure to obtain canagliflozin hemihydrate crystals having a narrow particle size distribution by removing a small part of the crystalline suspension in the crystallization vessel from said vessel and subjecting said part to particle size reduction of the formed crystals followed by heating and reintroducting said part of the crystalline suspension again in the crystallization vessel which is kept within a specific temperature range.

Claim (Index 12):
A process for preparing a crystalline drug substance comprising the consecutive steps of\n a) preparing a solution or suspension in a crystallization vessel of said drug substance in a solvent; b) cooling the said solution to a temperature such that the solution is in the metastable zone wherein nucleation is possible; c) cooling the solution of step b) to obtain a suspension of crystalline drug substance; d) removing a part of the crystalline suspension from the crystallization vessel in an amount that is less than the entire content and subjecting said part to particle size reduction, heating said part to a temperature higher than the temperature of the crystalline suspension in the crystallization vessel and returning said part back to the crystallization vessel; e) repeating step d) until the entire content of the crystallization vessel has undergone a sufficient number of turnovers until a desired particle size distribution is obtained.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 94.0
- Lexical Diversity: 1.55319
- Patent Class: 549.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15115440', '14888961', '15776794', '15291202', '15759562']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7029276120274865
- 35 USC 102 Novelty (BERT): 0.4882733995339977
- Combined Prediction Score: 0.6814621907781377
- Mean Citation Score: 191.759966
- Max Citation Score: 223.94632
- Similarity Product: 170.45200339778418

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test