PATENT CLAIM ANALYSIS

Application Number: 15953852
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["514", "221000"]

Abstract:
The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment of cyclophilin-related disorders.

Claim (Index 18):
A method for treating a cyclophilin-mediated disease or disorder in a subject in need thereof, comprising the step of administering to said subject a compound of formula I, or a pharmaceutically acceptable salt thereof, wherein:\n Ring A is \n each R\u2032 is independently \u2014R, halogen, -haloalkyl, -hydroxyalkyl, \u2014OR, \u2014C(O)R, \u2014CO 2 R, \u2014C(O)N(R) 2 , \u2014NRC(O)R, or \u2014N(R) 2 ; each R 1  is independently \u2014H or C 1-6  aliphatic which is optionally substituted; each R 1a  is independently \u2014H or C 1-6  aliphatic which is optionally substituted; or R 1  and R 1a  taken together with the atom to which they are attached form a 3-7 -membered carbocyclic ring optionally having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, which is optionally substituted; each R 2  is independently \u2014H or C 1-6  aliphatic which is optionally substituted; each R 2a  is independently \u2014H or C 1-6  aliphatic which is optionally substituted; X is CH 2  or O; or X and the bonds attached to X are absent; each R is independently hydrogen, C 1-6  aliphatic, C 3-10  aryl, a 3-8 -membered saturated or partially unsaturated carbocyclic ring, a 3-7 -membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 -membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; or two R groups on the same atom are taken together with the atom to which they are attached to form a C 3-10  aryl, a 3-8 -membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 -membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; m is 1 or 2; n is 1 or 2; and p is 1, 2, 3, 4, or 5.

Metadata:
- Claim Count in Document: 44.0
- Percentile: 91.0
- Lexical Diversity: 1.17391
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15474193', '15701842', '15370645', '15620049', '14945610']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7128912170579117
- 35 USC 102 Novelty (BERT): 0.5058481299893971
- Combined Prediction Score: 0.6921869083510602
- Mean Citation Score: 230.281312
- Max Citation Score: 268.14297
- Similarity Product: 215.8534945112604

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test