PATENT CLAIM ANALYSIS

Application Number: 15771152
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-11
Patent Classification: ["424", "001890"]

Abstract:
The present invention relates to new and improved methods of synthesizing radiolabelling agents which can be used to label biomolecules for use as radiopharmaceuticals. It further relates to certain novel radiolabelling agents and their use in such methods. PET imaging methods and methods of diagnosis employing such radiolabelling agents form a further aspect of the invention.

Claim (Index 24):
A positron emission tomography (PET) imaging method comprising:\n (a) providing a solid stationary phase which comprises a polymeric anion-exchange resin having bound thereto [ 18 F]fluoride anions; (b) contacting said solid stationary phase with a non-aqueous solution of a precursor compound of formula (I): optionally in the presence of an organic non-nucleophilic base, whereby to produce a radiofluorinated compound of formula (II): wherein: in formula (I), L is a positively charged leaving group; and in formulae (I) and (II), R is a group of the formula: wherein R\u2032 is an electron-withdrawing group; (c) reacting the compound of formula (II) with a compound of formula (III):\n H 2 N-biomolecule\u2003\u2003(III) \n to give a radiolabelled biomolecule of formula (IV): (d) administering said radiolabelled biomolecule of formula (IV) to a human or animal subject; and (e) acquiring a PET image of said subject.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 91.0
- Lexical Diversity: 1.51282
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15506351', '13256511', '14153491', '15593538', '12305253']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.712467616447737
- 35 USC 102 Novelty (BERT): 0.5161501734572612
- Combined Prediction Score: 0.6928358721486895
- Mean Citation Score: 228.959258
- Max Citation Score: 299.72873
- Similarity Product: 203.351167763902

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test