PATENT CLAIM ANALYSIS

Application Number: 15949000
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-10
Patent Classification: ["424", "450000"]

Abstract:
A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.

Claim (Index 1):
A method of preparing liposomal statins comprising:\n (a) preparing a lipid solution including phosphatidylcholine in the range of 15 wt. % to 40 wt. %, cholesterol in the range of 1 wt. % to 5 wt. %, vitamin-E in the range of 0 wt. % to 5 wt. a skin penetrating surfactant in the range of 2 wt % to 15 wt. %, and an organic solvent; (b) removing said solvent and forming a lipid cake; (c) hydrating said lipid cake with an aqueous media; (d) mixing said lipid cake in a mixer and subjecting said lipid cake to one or more freeze/thaw cycles; (e) extruding said lipid cake; (f) adding a cryo-protective agent; (g) lyophilizing to provide a powder liposomal statin; and wherein a statin is added to said lipid solution in step (a) or to said aqueous media used in step (c) where said statin comprises simvastatin, lovastatin or pravastatin.

Metadata:
- Claim Count in Document: 38.0
- Percentile: 91.0
- Lexical Diversity: 1.92982
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14477748', '12092628', '10423830', '14798877', '14365798']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.695262410932469
- 35 USC 102 Novelty (BERT): 0.4965010195089426
- Combined Prediction Score: 0.6753862717901163
- Mean Citation Score: 212.741742
- Max Citation Score: 223.69444
- Similarity Product: 151.90919574279786

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test