PATENT CLAIM ANALYSIS

Application Number: 16132928
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-04
Patent Classification: ["424", "138100"]

Abstract:
We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

Claim (Index 20):
The method of  claim 19 , wherein:\n the amplification primer comprises at least 10 but fewer than 600 contiguous nucleotide residues of a coding sequence of a IDH1 protein found in a tumor of the subject, or its complement, the at least 10 contiguous nucleic acid residues comprising: a first nucleotide that is present at a position in a mutant codon that corresponds to a wild type codon that encodes amino acid 132 in the wild type IDH1 polypeptide of SEQ ID NO: 130, wherein the mutant codon comprising the first nucleotide encodes an amino acid selected from the group consisting of: histidine (H), cysteine (C), serine (S), leucine (L), and glycine (G), wherein the amplification primer is labeled with a detectable label; the hybridization probe comprises at least 10 but fewer than 600 contiguous nucleotide residues of a coding sequence of a IDH1 protein found in a tumor of the subject, or its complement, the at least 10 contiguous nucleic acid residues comprising: a second nucleotide that is present at a position in a mutant codon that corresponds to a wild type codon that encodes amino acid 132 in the wild type IDH1 polypeptide of SEQ ID NO: 130, wherein the mutant codon comprising the second nucleotide encodes an amino acid selected from the group consisting of: histidine (H), cysteine (C), serine (S), leucine (L), and glycine (G), wherein the hybridization probe is labeled with a detectable label; or both.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 97.0
- Lexical Diversity: 1.37736
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13060191', '14102730', '15589615', '15238161', '15186188']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7834916015824107
- 35 USC 102 Novelty (BERT): 0.6430847118852346
- Combined Prediction Score: 0.7694509126126932
- Mean Citation Score: 526.99217
- Max Citation Score: 787.84033
- Similarity Product: 559.4979615583777

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test