PATENT CLAIM ANALYSIS

Application Number: 15566418
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-07
Patent Classification: ["514", "210000"]

Abstract:
Compounds of formula I are provided. Also provided are methods of preparing the compounds of formula (I), and methods of using the compounds of formula (I) as a negative allosteric modulator of a metabotropic glutamate receptor (mGluR) subtype 5.

Claim (Index 6):
The compound of  claim 1 , wherein the compound is selected from the following group: No. Name Structure ZD001 2-fluoro-5-(pyridin-2-ethynyl)-N-(4- fluorophenyl)benzamide   ZD002 (2-chloro-5-(pyridin-2-ethynyl)phenyl)(7- oxa-2-aza-spiro[3.5]nonan-2-yl)methanone   ZD003 (2-chloro-5-(pyridin-2-ethynyl)phenyl)(8- oxa-2-aza-spiro[4.5]dec-2-yl)methanone   ZD004 2-fluoro-N-(4-fluorophenyl)-5-((2-methyl- thiaZol-4-yl)ethynyl)benzamide   ZD005 (3-((2-methylthiazol-4-yl)ethynyl)phenyl) (3-trifluoromethyl-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl)methanone   ZD006 5-((1H-indazol-5-yl)ethynyl)-2-fluoro-N- (4-fluorophenyl)benzamide   ZD007 (3-((2-methylthiazol-4-yl)phenyl)(7-oxa-2- aza-spiro[3.5]nonan-2-yl)methanone   ZD008 (3-((2-methylthiazol-4-yl)phenyl)(8-oxa- 2-aza-spiro[4.5]dec-2-yl)methanone   ZD009 N-(4-fluorophenyl)-3-((2-methylthiazol-4- yl)ethynyl)benzamide   ZD010 N-(4-cyanophenyl)-3-((2-methylthiazol-4- yl)ethynyl)benzamide   ZD011 (1-methyl-3,4-dihydro-isoquinolin-2(1H- yl-3-((2-methyl-thiazol-4-yl)ethynyl) phenyl)methanone   ZD012 (3,4-dihydro-isoquinolin-2(1H)-yl)(3-((2- methyl-thiazol-4-yl)ethynyl)phenyl) methanone   ZD013 3-((2-methylthiazol-4-ylethynyl)-N- (pyridin-3-yl)benzamide   ZD014 3-((2-methylthiazol-4-ylethynyl)-N- phenylbenzamide   ZD015 3-((2-methylthiazol-4-ylethynyl)-N-(4- (trifluoromethyl)phenyl)benzamide   ZD017 N-(3-fluorophenyl)-3-((2-methylthiazol-4- yl)ethynyl)benzamide   ZD019 N-(3-cyanophenyl)-3-((2-methylthiazol-4- yl)ethynyl)benzamide   ZD036 2-chloro-N-(4-fluorophenyl)-5-(pyridin-2- ethynyl)benzamide   ZD037 2-chloro-N-(4-fluorophenyl)-5-((2-methyl- thiazol-4-yl)ethynyl)benzamide   ZD038 2-fluoro-N-(4-fluorophenyl)-5-(pyridin-3- ethynyl)benzamide   ZD039 2-fluoro-N-(4-fluorophenyl)-5-(pyridin-4- ethynyl)benzamide   ZD040 N-(4-fluorophenyl)-2-methyl-5-(pyridin-2- ethynyl)benzamide   ZD041 N-(4-fluorophenyl)-2-methyl-5-((2-methyl- thiazol-4-yl)ethynyl)benzamide   ZD042 2-fluoro-5-(pyridin-2-eThynyl)-N- (pyridin-3-yl)benzamide   ZD043 2-fluoro-5-((2-methylthiazol-4-ylethynyl)- N-(pyridin-3-yl)benzamide   ZD044 N-(4-cyanophenyl)-2-fluoro-5-(pyridin-2- ethynyl)benzamide   ZD045 N-(4-cyanophenyl)2-fluoro-5-((2-methyl- thiazol-4-yl)ethynyl)benzamide   ZD046 (3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-(pyridin-2-ylethynyl)phenyl) methanone   ZD047 (3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-((2-methyl-thiazol-4-yl)ethynyl) phenyl)methanone   ZD048 (2-fluoro-5-(pyridin-2-ylethynyl)phenyl) (1-methyl-3,4-dihydro-isoquinolin-2(1H)- yl)methanone   ZD049 (2-fluoro-5-((2-methyl-thiazol-4-yl) ethynyl)phenyl)(1-methyl-3,4-dihydro- isoquinolin-2(1H)-yl)methanone   ZD050 2-fluoro-5-((2-methylthiazol-4-ylethynyl)- N-(pyridin-3-yl)nicotinaMide   ZD051 2-fluoro-N-(4-fluorophenyl)-5-(pyridin-2- ylethynyl)nicotinamide   ZD052 (3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-((2-methyl-thiazol-4-yl)ethynyl) pyridin-3-yl)methanone   ZD053 2-fluoro-N-(4-fluorophenyl)-5-((2-methyl- thiazol-4-yl)ethynyl)nicotinamide   ZD054 2-chloro-N-(4-fluorophenyl)-5-((2-methyl- thiazol-4-yl)ethynyl)nicotinamide   ZD055 2-fluoro-5-(pyridin-2-ylethynyl)-N- (pyridin-3-yl)nicotinamide   ZD056 (3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-(pyridin-2-ylethynyl)pyridin-3-yl) methanone   ZD057 2-fluoro-5-((2-methylthiazol-4-yl)ethynyl)- N-benzoylaniline   ZD058 2-cyano-5-((2-methylthiazol-4-ylethynyl)- N-(pyridin-3-yl)benzamide   ZD059 5-((2-methylthiazol-4-ylethynyl)-N- (pyridin-3-yl)-2-(trifluoromethyl)benzamide   ZD060 N-(4-fluorophenyl)-5-((2-methylthiazol-4- yl)ethynyl)-2-(trifluoromethyl)benzamide   ZD061 2-cyano-N-(4-f!uorophenyl)-5-((2- methylthiazol-4-yl)ethynyl)benzamide   ZD062 4-((2-methylthiazol-4-yl)ethynyl)-2- (1,2,3,4-dihydroisoquinolin-2-carbonyl) benzonitrile   ZD063 (3,4-dihydro-isoquinolin-2(1H)-yl)(5-((2- methyl-thiazol-4-yl)ethynyl)-2- (trifluoromethyl)phenyl)methanone   ZD064 2-fluoro-N-(2-fluorophenyl)-5-((2- methylthiazol-4-yl)ethynyl)benzamide   ZD065 2-fluoro-N-(3-fluorophenyl)-5-((2- methylthiazol-4-yl)ethynyl)benzamide   ZD066 N-(3,4-difluorophenyl)-2-fluoro-5-((2- methylthiazol-4-yl)ethynyl)benzamide   ZD067 N-(2,4-difluorophenyl)-2-fluoro-5-((2- methylthiazol-4-yl)ethynyl)benzamide   ZD068 N-(4-chlorophenyl)-2-fluoro-5-((2-methyl- thiazol-4-yl)ethynyl)benzamide   ZD069 2-fluoro-5-((2-methylthiazol-4-ylethynyl)- N-(4-(trifluoromethyl)phenyl)benzamide   ZD070 2-fluoro-N-(4-methoxyphenyl)-5-((2- methylthiazol-4-yl)ethynyl)benzamide   ZD071 2-fluoro-5-((2-methylthiazol-4-ylethynyl)- N-(pyridin-2-yl)benzamide   ZD072 2-fluoro-5-((2-methylthiazol-4-ylethynyl)- N-(pyridin-4-yl)benzamide   ZD073 2-fluoro-N-(6-fluoropyridin-3-yl)-5-((2- methylthiazol-4-yl)ethynyl)benzamide   ZD074 N-(6-chloropyridin-3-yl)-2-fluoro-5-((2- methylthiazol-4-yl)ethynyl)benzamide   ZD075 2-fluoro-5-((2-methylthiazol-4-ylethynyl)- N-(p-methylphenyl)benzamide   ZD076 2-fluoro-N-(pyridin-3-yl)-5-(thiazol-4- ylethynyl)benzamide   ZD077 2-fluoro-5-((2-fluorothiazol-4-yl)ethynyl)- N-(pyridin-3-yl)benzamide   ZD078 5-((2-chlorothiazol-4-ylethynyl)-2-fluoro- N-(pyridin-3-yl)benzamide   ZD079 2-fluoro-N-(pyridin-3-yl)-5-((2- (trifluoromethyl)thiazol-4-yl)ethynyl) benzamide   ZD080 2-fluoro-5-((6-methylpyridin-2-yl) ethynyl)-N-(pyridin-3-yl)benzamide   ZD081 2-fluoro-5-((6-fluoropyridin-2-yl) ethynyl)-N-(pyridin-3-yl)benzamide   ZD082 5-((6-chloropyridin-2-yl)ethynyl)-2- fluoro-N-(pyridin-3-yl)benzamide   ZD083 2-fluoro-N-(pyridin-3-yl)-5-((6-(trifluoro- methyl)pyridin-2-yl)ethynyl)benzamide   ZD084 5-((6-cyanopyridin-2-yl)ethynyl)-2- fluoro-N-(pyridin-3-yl)benzamide   ZD085 2-fluoro-N-(pyridin-3-yl)-5-(pyrimidin-5- ylethynyl)benzamide   ZD086 2-fluoro-5-((2-methylpyrimidin-5-yl) ethynyl)-N-(pyridin-3-yl)benzaMide   ZD087 2-fluoro-N-(4-fluorophenyl)-5-((2- methylpyrimidin-5-yl)ethynyl)benzamide   ZD088 (3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-((2-methylpyrimidin-5-yl)ethynyl) phenylmethanone   ZD089 2-fluoro-5-((2-methyloxazol-4-ylethynyl)- N-(pyridin-3-yl)benzamide   ZD090 2-fluoro-N-(4-fluorophenyl)-5-((2- methyloxazol-4-yl)ethynyl)benzamide   ZD091 (3,4-dihydro-isoquinolin-2(1H)-yl)(2- fluoro-5-((2-methyloxazol-4-yl)ethynyl) phenyl)methanone   ZD092 (3,4-dihydro-isoquinolin-2(1H)-yl)(5-((3- 5-dimethylisoxazol-4-yl)ethynyl)-2- fluorophenyl)methanone   ZD093 5-((3,5-dimethylisoxazol-4-ylethynyl)-2- fluoro-N-(pyridin-3-yl)benzamide   ZD094 5-((3,5-dimethylisoxazol-4-ylethynyl)-2- fluoro-N-(4-fluorophenyl)benzamide

Metadata:
- Claim Count in Document: 22.0
- Percentile: 88.0
- Lexical Diversity: 1.71429
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14344957', '12908588', '15771920', '12912124', '13542234']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8164676172635366
- 35 USC 102 Novelty (BERT): 0.5297032247206943
- Combined Prediction Score: 0.7877911780092524
- Mean Citation Score: 333.88199999999995
- Max Citation Score: 349.1565
- Similarity Product: 295.70344458720086

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test