PATENT CLAIM ANALYSIS

Application Number: 15765860
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["435", "455000"]

Abstract:
The present invention provides methods and compositions to improve the efficiency of somatic cell nuclear transfer (SCNT) of human cells and the consequent production of human nuclear transfer ESC (hNT-ESCs). More specifically, the present invention relates to the discovery that trimethylation of Histone H3-Lysine 9 (H3K9me3) in reprogramming resistant regions (RRRs) in the nuclear genetic material of human donor somatic cells prevents efficient human somatic cell nuclear reprogramming or SCNT. The present invention provide methods and compositions to decrease H3K9me3 in methods to improve efficacy of hSCNT by exogenous or overexpression of the demethylase KDM4 family and/or inhibiting methylation of H3K9me3 by inhibiting the histone methyltransferases SUV39h1 and/or SUV39h2.

Claim (Index 8):
The method of  claim 1 , wherein the agent increases the expression or activity of at least one of: KDM4A (JMJD2A), KDM4B (JMJD2B), KDM4C (JMJD2C), KDM4D (JMJD4D) or KDM4E (JMJD2E).

Metadata:
- Claim Count in Document: 28.0
- Percentile: 91.0
- Lexical Diversity: 1.86154
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14276810', '12122557', '15895976', '14775594', '11968745']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6213986132882408
- 35 USC 102 Novelty (BERT): 0.5463970027159976
- Combined Prediction Score: 0.6138984522310165
- Mean Citation Score: 340.354036
- Max Citation Score: 444.93427
- Similarity Product: 211.81781000328303

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test