PATENT CLAIM ANALYSIS

Application Number: 15774223
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-11
Patent Classification: ["424", "233100"]

Abstract:
Compositions and methods are provided for modulating adeno-associated virus (AAV) infection. For example, compositions and methods are provided for enhancing permissiveness of a target cell to AAV infection (e.g., by increasing levels of AAVR (KIAA0319L) in the cell), for reducing permissiveness of a target cell to AAV infection (e.g., by reducing levels of AAVR in the cell), and for nucleic acid delivery (e.g., by (i) increasing permissiveness of a target cell to AAV infection, e.g., by increasing the amount of AAVR in the cell; and (ii) contacting the target cell with an AAV particle that includes a nucleic acid of interest). Also provided are screening methods and kits for practicing the methods of the disclosure.

Claim (Index 25):
The genetically modified mammalian cell of  claim 23  or  claim 24 , wherein said protein selected from AAVR, GPR108, TM9SF2, VPS29, VPS54, VPS52, and ATP2C1 comprises a wild type amino acid sequence.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 93.0
- Lexical Diversity: 2.66038
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['10880297', '15367734', '15681267', '15435212', '13840224']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7226541165713992
- 35 USC 102 Novelty (BERT): 0.527273543048421
- Combined Prediction Score: 0.7031160592191014
- Mean Citation Score: 312.9323080000001
- Max Citation Score: 317.23126
- Similarity Product: 226.6550637614536

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test