PATENT CLAIM ANALYSIS

Application Number: 15915554
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-07
Patent Classification: ["435", "007920"]

Abstract:
Methods and kits are provided for amplifying and detecting misfolded proteins from samples, for example, from patients having Alzheimer's Disease, Parkinson's Disease, and the like. For example, a method for determining a presence of soluble, misfolded protein in a sample may include contacting the sample with a monomeric, folded protein to form an incubation mixture; conducting an incubation cycle two or more times effective to form an amplified portion of misfolded protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded protein; physically disrupting the incubation mixture effective to break up at least a portion of any protein aggregate present; and determining the presence of the soluble, misfolded protein in the sample by detecting at least a portion of the soluble, misfolded protein. The monomeric, folded protein and the soluble, misfolded protein may exclude prion protein (PrP) and isoforms thereof.

Claim (Index 18):
The method of  claim 17 , the solid phase comprising one or more of a magnetic bead and a multiwell plate.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 90.0
- Lexical Diversity: 2.24675
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14852471', '12177012', '13833008', '15424444', '14330445']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5926086685643467
- 35 USC 102 Novelty (BERT): 0.626375637487541
- Combined Prediction Score: 0.5959853654566661
- Mean Citation Score: 334.639886
- Max Citation Score: 699.6428
- Similarity Product: 514.5433101872443

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test