PATENT CLAIM ANALYSIS

Application Number: 16025652
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["424", "094300"]

Abstract:
The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related diseases and disorders.

Claim (Index 8):
A cystathionine beta-synthase (CBS) variant protein comprising:\n (a) an amino acid sequence at least 60% identical to SEQ ID NO: 2; (b) a truncation of the C-terminal regulatory region, and (c) at least one polyethylene glycol (PEG) molecule, wherein the protein retains enzymatic activity for at least 24 hours.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 95.0
- Lexical Diversity: 1.06897
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15235355', '14687389', '13803804', '15492671', '15774755']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8507900625768491
- 35 USC 102 Novelty (BERT): 0.6174472488325558
- Combined Prediction Score: 0.8274557812024197
- Mean Citation Score: 653.751418
- Max Citation Score: 741.7077
- Similarity Product: 496.32793900544647

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test