PATENT CLAIM ANALYSIS

Application Number: 15887214
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["546", "160000"]

Abstract:
Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR 1  or N; B is CR 3  or N; D is CR 4  or N; L 1  is —(CR 7 R 7 ) m —; L 2  is —(CR 7 R 7 ) n —; and X, Z, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6  are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Claim (Index 11):
The compound according to  claim 1  or a salt thereof, where said compound is: 2-(5-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (1); 3-chloro-N-(2,5-dimethylphenyl)-2-(((2,5-dimethylphenyl)amino)methyl)-6-(1-methyl-1H-pyrazol-4-yl)quinolin-4-amine (2); 5-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-(((2,5-dimethylphenyl)amino)methyl)quinolin-6-yl)picolinonitrile (3); 2-(5-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-(hydroxymethyl)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (4); ethyl 3-chloro-6-(6-cyanopyridin-3-yl)-4-((2,5-dimethylphenyl)amino)quinoline-2-carboxylate (5); tert-butyl 4-(4-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-methylquinolin-6-yl)benzyl)piperazine-1-carboxylate (6); 3-chloro-N-(2,5-dimethylphenyl)-2-methyl-6-(4-(piperazin-1-ylmethyl)phenyl)quinolin-4-amine (7); 5-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-methylquinolin-6-yl)-N-methylpicolinamide (8); 5-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-methylquinolin-6-yl)picolinic acid (9); 2-(5-(3-chloro-4-((2-fluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (10); 2-(5-(3-chloro-4-((phenylamino)methyl)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (11); 2-(5-(3-chloro-4-((2-(dimethylamino)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (12); (S)-(4-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)benzyl)glycine (13); methyl (S)-2-(4-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetate (14); (S)-2-(4-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyridin-2-yl)piperazin-1-yl)acetic acid (15); (S)-2-(4-(4-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)piperazin-1-yl)acetic acid (16); (R)-3-chloro-N-(1-(2-fluorophenyl)ethyl)-6-(2-(methylamino)pyrimidin-5-yl)quinolin-4-amine (17); 4-(5-(3,8-dichloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-2-one (18); 3,8-dichloro-N-(1-(2-fluorophenyl)ethyl)-6-(2-(methylamino)pyrimidin-5-yl)quinolin-4-amine (19); 3,8-dichloro-N-(1-(2-fluorophenyl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)quinolin-4-amine (20); 2-(4-(3,8-dichloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (21); 4-(3,8-dichloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)-N-methylbenzenesulfonamide (22); 6-(1-((3-chloro-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl)quinolin-4-yl)amino)propyl)-5-fluoropicolinamide (23); 6-(1-((3-chloro-6-(4-(2-hydroxypropan-2-yl)phenyl)quinolin-4-yl)amino) propyl)-5-fluoropicolinamide (24); 6-(1-((3-chloro-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl) quinolin-4-yl)amino)ethyl)-5-fluoropicolinamide (25 and 26); 6-(1-((3-chloro-6-(4-(2-hydroxypropan-2-yl)phenyl)quinolin-4-yl)amino)ethyl)-5-fluoropicolinamide (27); 6-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-5-fluoropicolinamide (28); (R)-3-chloro-6-(4-((ethylamino)methyl)phenyl)-N-(1-(2-fluorophenyl)ethyl)quinolin-4-amine (29); (R)-6-(4-(azetidin-1-ylmethyl)phenyl)-3-chloro-N-(1-(2-fluorophenyl)ethyl)quinolin-4-amine (30); 3-chloro-6-(6-cyanopyridin-3-yl)-4-((2,5-dimethylphenyl)amino)quinoline-2-carboxylic acid (31); 3-chloro-6-(6-cyanopyridin-3-yl)-4-((2,5-dimethylphenyl)amino)-N-(pyridin-3-yl)quinoline-2-carboxamide (32); 3-chloro-6-(6-cyanopyridin-3-yl)-4-((2,5-dimethylphenyl)amino)-N-methylquinoline-2-carboxamide (33); 3-chloro-6-(6-cyanopyridin-3-yl)-4-((2,5-dimethylphenyl)amino)-N,N-dimethylquinoline-2-carboxamide (34); 3-chloro-6-(6-cyanopyridin-3-yl)-4-((2,5-dimethylphenyl)amino)-N-phenylquinoline-2-carboxamide (35); 3-chloro-6-(6-cyanopyridin-3-yl)-4-((2,5-dimethylphenyl)amino)-N-(pyridin-4-yl)quinoline-2-carboxamide (36); 6-(6-carbamoylpyridin-3-yl)-3-chloro-4-((2,5-dimethylphenyl)amino)-N-(pyridin-3-yl)quinoline-2-carboxamide (37); 6-(1-((3-chloro-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-5-fluoro-N-phenylpicolinamide (38); 6-(1-((3-chloro-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-N-ethyl-5-fluoropicolinamide (39); 5-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-(hydroxymethyl)quinolin-6-yl)picolinonitrile (40); 5-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-((pyridin-3-yloxy)methyl)quinolin-6-yl)picolinonitrile (41); 5-(2-(azidomethyl)-3-chloro-4-((2,5-dimethylphenyl)amino)quinolin-6-yl)picolinonitrile (42); 5-(2-(aminomethyl)-3-chloro-4-((2,5-dimethylphenyl)amino)quinolin-6-yl)picolinonitrile (43); 2-(5-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-(hydroxymethyl)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (44); 2-(4-(5-(2-amino-3-chloro-4-((2,5-dimethylphenyl)amino)quinolin-6-yl)pyrimidin-2-yl) piperazin-1-yl)acetic acid (45); 2-(4-(5-(2-amino-3-chloro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl) acetic acid (46); 2-(5-(3-chloro-4-(indolin-1-ylamino) quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (47); 2-(5-(3-chloro-4-((2-methylindolin-1-yl)amino) quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (48); 1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)-1-(2-fluorophenyl)-2-methylpropan-2-ol (49); 2-(5-(3-chloro-4-((1-cyclobutylpropyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (50); 2-(5-(3-chloro-4-((2-methyl-1-(pyridin-2-yl)propyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (51); 2-(5-(3-chloro-4-((1-(pyridin-2-yl)propyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (52); (R)-2-(5-(3-chloro-4-((1-(2-chloro-5-fluoropyridin-4-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (53); 2-(5-(3-chloro-4-(2-methyl-2-phenylhydrazinyl)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (54); 2-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (55); 2-(5-(4-((4-bromo-2-(1H-pyrazol-1-yl)benzyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl) propan-2-ol (56); 2-(5-(3-chloro-4-((2,2-difluoro-1-phenylethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (57); (R)-2-(5-(3-chloro-4-((1-cyclohexylethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (58); (S)-2-(5-(3-chloro-4-((1-cyclohexylethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (59); tert-butyl (S)-3-((S)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl) quinolin-4-yl)amino)ethyl)piperidine-1-carboxylate (60); tert-butyl (R)-3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)piperidine-1-carboxylate (61); 2-(5-(3-chloro-4-((1-(4-chloropyridin-2-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (62); (R)-2-(5-(3-chloro-4-((1-(4-chloropyridin-2-yl)but-3-en-1-yl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (63); 2-(5-(4-((1-(6-bromo-3-fluoropyridin-2-yl)propyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (64); N-(4-aminobutyl)-5-(3-chloro-4-((2,5-dimethylphenyl)amino)-2-methylquinolin-6-yl)picolinamide (65); 2-(5-(3-chloro-4-((ethyl(phenyl)amino)methyl)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (66); 2-(5-(3-chloro-4-(((2-fluorophenyl)(methyl)amino)methyl) quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (67); 2-(5-(3-chloro-4-((ethyl(2-fluorophenyl)amino)methyl)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (68); 1-((5-(2-amino-3-chloro-4-((2,5-dimethylphenyl)amino)quinolin-6-yl)pyrimidin-2-yl)amino)-2-methylpropan-2-ol (69); 2-((5-(2-amino-3-chloro-4-((2,5-dimethylphenyl)amino)quinolin-6-yl)pyrimidin-2-yl)amino)ethan-1-ol (70); 2-((5-(2-amino-3-chloro-4-((2,5-dimethylphenyl)amino)quinolin-6-yl)pyrimidin-2-yl)amino) propane-1,3-diol (71); 4-(5-(2-amino-3-chloro-4-((2,5-dimethylphenyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-2-one (72); 3-((5-(2-amino-3-chloro-4-((2,5-dimethylphenyl)amino) quinolin-6-yl)pyrimidin-2-yl)amino)propane-1,2-diol (73); (S)-4-(5-(3-chloro-4-(((S)-2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazine-2-carboxylic acid (74); (S)-4-amino-1-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) piperidine-4-carboxylic acid (75); (S)-2-(4-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)-2-oxopiperazin-1-yl)acetic acid (76); 2-(4-(5-(3-chloro-4-(((S)-2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-2-yl) acetic acid (77); (S)-2-(1-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperidin-4-yl)acetic acid (78); (S)-4-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-2-one (79); (S)-1-((5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)amino)-2-methylpropan-2-ol (80); (R)-2-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyridin-2-yl)-2-oxopiperazin-1-yl)acetic acid (81); (R)-2-(1-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyridin-2-yl)piperidin-4-yl)acetic acid (82); ((R)-4-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)pyridin-2-yl)morpholin-2-yl)methanol (83); ((S)-4-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyridin-2-yl)piperazin-2-yl)methanol (84); ((R)-4-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyridin-2-yl)morpholin-3-yl)methanol (85); ((S)-4-(5-(3-chloro-4-(((S)-2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-2-yl)methanol (86); ((S)-4-(5-(3-chloro-4-(((S)-2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)morpholin-2-yl)methanol (87); (R)-3-chloro-N-(1-(2-fluorophenyl)ethyl)-6-(6-(piperazin-1-yl)pyridin-3-yl)quinolin-4-amine (88); (R)-2-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)-N-methylacetamide (89); (R)-2-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetamide (90); (R)-2-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)-N-(methylsulfonyl)acetamide (91); (S)-2-(4-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetic acid (92); (S)-3-((tert-butoxycarbonyl)amino)-2-(4-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)propanoic acid (93); (S)-3-amino-2-(4-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl) propanoic acid (94); (S)-3-acetamido-2-(4-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)propanoic acid (95); 2-(5-(3-chloro-4-(((S)-1-((S)-piperidin-3-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (96 and 97); (R)-2-(5-(3-chloro-4-((1-(piperidin-3-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (98); methyl (S)-3-amino-2-(4-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) piperazin-1-yl)propanoate (99); 2-amino-2-(4-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)phenyl)ethan-1-ol (100); (R)-N-(4-aminobutyl)-5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)picolinamide (101); (R)-6-(4-(1-aminocyclopropyl)phenyl)-3-chloro-N-(1-(2-fluorophenyl)ethyl)quinolin-4-amine (102); (S)-3-((S)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)piperidine-1-carboxamide (103); (R)-3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)piperidine-1-carboxamide (104); 2-(5-(3-chloro-4-(((S)-1-((S)-1-ethylpiperidin-3-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (105); 3-((S)-3-((S)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)piperidin-1-yl)propane-1,2-diol (106); 1-((S)-3-((S)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)piperidin-1-yl) ethanone (107); 1-((R)-3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)piperidin-1-yl)ethan-1-one (108); methyl (S)-3-acetamido-2-(4-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)propanoate (109); (R)-N-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)benzyl)acetamide (110); (R)-N-(1-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)cyclobutyl) methanesulfonamide (111); 3-(4-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-one (112); (R)-N-(1-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)cyclobutyl)acetamide (113); (R)-4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)-4-hydroxycyclohexan-1-one (114); 3-amino-3-(4-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)propanoic acid (115); 2-amino-3-(4-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl) propanoic acid (116); (R)-2-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)-1,3-difluoropropan-2-ol (117); (R)-6-(4-(1-aminocyclobutyl)phenyl)-3-chloro-N-(1-(2-fluorophenyl)ethyl)quinolin-4-amine (118); (R)-3-amino-3-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)phenyl)cyclobutan-1-ol ((119); (R)-1-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl)cyclopentan-1-ol (120); (1R,2R)-1-(5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)cyclopentane-1,2-diol (121); 6-bromo-3,8-dichloro-N-(1-(2-fluorophenyl)ethyl)quinolin-4-amine (122); (R)-1-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyridin-2-yl)piperazin-1-yl)prop-2-en-1-one (123); (R)-N-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)-N-methylacrylamide (124); (R)-1-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyridin-2-yl) piperazin-1-yl)but-2-yn-1-one (125); 2-(5-(3-chloro-4-((1-(3-fluoro-6-vinylpyridin-2-yl)propyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (126); 1-(6-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)propyl)-5-fluoropyridin-2-yl)ethane-1,2-diol (127); 6-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)propyl)-5-fluoropicolinic acid (128); 6-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)propyl)-5-fluoropicolinamide (129); 2-(5-(3-chloro-4-((1-(3-fluoro-6-(hydroxymethyl)pyridin-2-yl)propyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (130); (R)-N-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)-4-hydroxycyclohexyl)acetamide (131 and 132); 2-(5-(3-chloro-4-((1-(furan-2-yl)propan-2-yl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (133); 2-(5-(3-chloro-4-((1-(2,3,3-trimethylcyclopent-1-en-1-yl)propan-2-yl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (134); (R)-2-(5-(3-chloro-4-((1-(3-morpholinophenyl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (136); 2-(5-(3-chloro-4-((1-(4-(trifluoromethoxy)phenyl) propan-2-yl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (137); 4-(2-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)propyl)-2-methylisoquinolin-1(2H)-one (138); 2-(5-(3-chloro-4-((1-cyclopentylpropan-2-yl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (140); 2-(5-(3-chloro-4-((4-(6-methyl-1H-indol-3-yl)butan-2-yl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (141); 2-(5-(3-chloro-4-((1-(1-(4-chlorophenyl)cyclopentyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (142); 3-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)-1,1-diphenylbutan-1-ol (143); 2-(5-(4-((1-(1H-indol-4-yl)propan-2-yl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (144); 2-(5-(3-chloro-4-(4-(trifluoromethyl)benzylamino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (145); 2-(5-(3-chloro-4-((2-(trifluoromethyl)benzyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (146); 2-(5-(3-chloro-4-((1-(3-(trifluoromethyl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (147); 2-(5-(3-chloro-4-((4-(difluoromethoxy)benzyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (148); 2-(5-(3-chloro-4-((1-(2,5-dimethylphenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (149); 2-(5-(3-chloro-4-((1-(4-(trifluoromethyl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (150); 2-(5-(3-chloro-4-((1-(2-(trifluoromethyl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (151); 2-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (152); 2-(5-(3-chloro-4-((1-(2-chlorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (153); (R)-2-(5-(3-chloro-4-((1-phenylethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (154); 2-(5-(3-chloro-4-((1-(3-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (155); 2-(5-(3-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (156); 2-(5-(3-chloro-4-((1-(4-fluorophenyl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (157); 2-(5-(3-chloro-4-((1-(2-fluorophenyl)cyclopropyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (158); 2-(5-(3-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (159); 2-(5-(3-chloro-4-((1-(2,5-difluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (160); 2-(5-(3-chloro-4-((1-phenylcyclopropyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (161); 2-(5-(3-chloro-4-((1-(3-fluoropyridin-4-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (162); 2-(5-(3-chloro-4-((1-(2,4-difluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (163); 2-(5-(3-chloro-4-((2,2,2-trifluoro-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (164); 2-(5-(3-chloro-4-((3,3,3-trifluoro-1-phenylpropyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (165); 2-(4-(3-chloro-4-((1-(pyridin-3-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (166); 3-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)-3-(2-fluorophenyl)propan-1-ol (167); 2-(5-(3-chloro-4-((3,3-difluoro-1-(2-fluorophenyl)propyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (168); 2-(5-(3-chloro-4-((3,3,3-trifluoro-1-(2-fluorophenyl)propyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (169); 2-(4-(3-chloro-4-((1-(3-fluoropyridin-2-yl)ethyl)amino) quinolin-6-yl)phenyl)propan-2-ol (170); 2-(5-(3-chloro-4-((1-(3-fluoropyridin-2-yl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (171); 2-(4-(3-chloro-4-((1-(isothiazol-4-yl)ethyl)amino) quinolin-6-yl)phenyl)propan-2-ol (172); 2-(4-(3-chloro-4-((1-(pyrimidin-4-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (173); 2-(4-(3-chloro-4-((1-(isoxazol-3-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (174); 2-(4-(3-chloro-4-((1-(pyridin-2-yl)ethyl)amino)quinolin-6-yl)phenyl) propan-2-ol (175); 2-(4-(3-chloro-4-((1-(pyridin-4-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (176); 2-(4-(3-chloro-4-((1-(pyrimidin-2-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (177); 2-(4-(3-chloro-4-((1-(4-methylpyrimidin-2-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (178); 2-(4-(3-chloro-4-((1-(oxazol-2-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (179); 2-(5-(4-(2,5-dimethylphenylamino)-2-methoxy-3-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (180); 4-((2,5-dimethylphenyl)amino)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-3-methylquinolin-2-ol (181); 2-(5-(3-chloro-4-((2-(3-(trifluoromethyl)phenyl)propan-2-yl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (182); 2-(5-(4-((2,5-dimethylphenyl)amino)-3-fluoro-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (183); 2-(5-(4-((2,5-dimethylphenyl)amino)-2,3-dimethylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (184); 2-(5-(3-chloro-4-((2-(4-(trifluoromethyl)phenyl)propan-2-yl)amino) quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (185); 5-(4-((2,5-dimethylphenyl)amino)-3-fluoro-2-methylquinolin-6-yl)-N-methylpicolinamide (186); 2-(4-(5-(4-((2,5-dimethylphenyl)amino)-3-fluoro-2-methylquinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetic acid (187); (R)-2-(5-(7-chloro-3-fluoro-8-((1-(2-fluoro-5-vinylphenyl)ethyl)amino)-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (188); 2-(5-(3-chloro-4-((1-(2-fluorophenyl)-2-methylpropyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (189); 2-(5-(3-chloro-4-((1-(2-fluorophenyl)propyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (190); 2-(5-(3-chloro-4-((cyclopropyl(2-fluorophenyl)methyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (191); 2-(4-(3-chloro-4-((1-(furan-2-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (192); (R)-2-(5-(7-chloro-3-fluoro-8-((1-phenylethyl)amino)-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (193); 2-(4-(3-chloro-4-((1-(thiazol-2-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (194); 2-(4-(3-chloro-4-((1-(1-methyl-1H-pyrazol-5-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (195); 2-(4-(3-chloro-4-((1-(thiophen-3-yl)ethyl)amino)quinolin-6-yl)phenyl) propan-2-ol (196); 2-(4-(3-chloro-4-((1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (197); 2-(4-(3-chloro-4-((1-(pyrazin-2-yl)ethyl)amino)quinolin-6-yl)phenyl) propan-2-ol (198); 2-(4-(3-chloro-4-((1-(thiophen-2-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (199); 2-(4-(3-chloro-4-((1-(1-methyl-1H-pyrazol-3-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (200); 2-(4-(3-chloro-4-((1-(1-methyl-1H-imidazol-2-yl)ethyl)amino)quinolin-6-yl)phenyl) propan-2-ol (201); 2-(4-(3-chloro-4-((1-(thiazol-4-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (202); 2-(4-(3-chloro-4-((1-(oxazol-5-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (203); 2-(4-(3-chloro-4-((1-(furan-3-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (204); 2-(4-(3-chloro-4-((1-(1-methyl-1H-imidazol-4-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (205); 2-(4-(3-chloro-4-((1-(oxazol-4-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (206); (S)-2-(5-(7-chloro-8-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)-3-fluoro-1,5-naphthyridin-2-yl)pyrimidin-2-yl) propan-2-ol (207); (S)-2-(5-(7-chloro-3-fluoro-8-((1-phenylethyl)amino)-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (208); 2-(5-(7-chloro-3-fluoro-8-((1-(2-fluorophenyl)ethyl)amino)-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (209); 2-(4-(3-chloro-4-((1-(1-methyl-1H-imidazol-5-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (210); 2-(4-(3-chloro-4-((1-(thiazol-5-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (211); 2-(5-(7-chloro-8-((2,2-difluoro-1-phenylethyl)amino)-3-fluoro-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (212); (R)-2-(5-(7-chloro-3-fluoro-6-methyl-8-((1-phenylethyl)amino)-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (213); 2-(5-(7-chloro-8-((2,2-difluoro-1-phenylethyl)amino)-3-fluoro-6-methyl-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (214); (R)-2-(5-(7-chloro-8-((2,2-difluoro-1-(2-fluoro-5-vinylphenyl)ethyl)amino)-3-fluoro-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (215); 2-(5-(7-chloro-8-((2,2-difluoro-1-(3-vinylphenyl)ethyl)amino)-3-fluoro-1,5-naphthyridin-2-yl)pyrimidin-2-yl) propan-2-ol (216); (R)-2-(5-(3-chloro-4-(1-(2-fluorophenyl)ethylamino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (217); 2-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl) pyrimidin-2-yl)propan-2-ol (218); (R)-3-chloro-N-(1-(2-fluorophenyl)ethyl)-6-(2-morpholinopyrimidin-5-yl)quinolin-4-amine (219); (R)-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)methanol (220); (R)-3-chloro-N-(1-(2-fluorophenyl)ethyl)-6-(6-(methylsulfonyl)pyridin-3-yl)quinolin-4-amine (221); (R)-3-chloro-6-(2-ethoxypyrimidin-5-yl)-N-(1-(2-fluorophenyl)ethyl)quinolin-4-amine (222); (R)-3-chloro-6-(2-ethylpyrimidin-5-yl)-N-(1-(2-fluorophenyl)ethyl)quinolin-4-amine (223); methyl (R)-2-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetate (224); (R)-4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)thiomorpholine 1,1-dioxide (225); (R)-4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-2-one (226); (R)-3-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)oxetan-3-ol (227); (R)-2-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (228); 2-(5-(3-chloro-4-((2-fluoro-1-(2-fluorophenyl)-2-methylpropyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (229); 2-(5-(3-chloro-4-((3-fluoro-1-(2-fluorophenyl)propyl)amino) quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (230); 2-(4-(3-chloro-4-((3-fluoro-1-(2-fluorophenyl) propyl)amino)quinolin-6-yl)phenyl)propan-2-ol (232); (R)-2-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetonitrile (233); (R)-6-(2-(4-((2H-tetrazol-5-yl)methyl)piperazin-1-yl)pyrimidin-5-yl)-3-chloro-N-(1-(2-fluorophenyl)ethyl)quinolin-4-amine (237); (R)-2-(5-(3-chloro-4-((3-fluoro-1-(2-fluorophenyl)propyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (238); \u00b1 2-(5-(8-((1-(3-aminophenyl)ethyl)amino)-7-chloro-3-fluoro-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (239); (R)-2-(5-(4-((1-(2-fluorophenyl)ethyl)amino)-3-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (240); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (homochiral) (241); 2-(4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetic acid (242); ethyl-1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperidine-4-carboxylate (243); 1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperidine-4-carboxylic acid (244); 2-(1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperidin-4-yl)propan-2-ol (245); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (246); 2-(5-(3-chloro-8-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (247); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl) pyrimidin-2-yl)propan-2-ol (248); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (249); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (250); 4-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)-4-hydroxycyclohexane-1-carboxylic acid (251); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (252); 2-(5-(3-chloro-5-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (253); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propane-1,2-diol (254); 5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)pyrimidine-2-carbonitrile (255); 1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)ethane-1,2-diol (256); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propane-1,2-diol (257); 2-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)-2-fluorophenyl)propan-2-ol (258); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propane-1,2-diol (259); (4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)(cyclopropyl)methanol (260); (4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)(cyclopropyl) methanol (261); (4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl) (cyclopropyl)methanol (262); (4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)(cyclopropyl)methanol (263); (1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)phenyl)cyclopropyl)methanol (264); (1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)cyclopropyl) methanol (265); 2-(1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperidin-4-yl)acetic acid (266); 2-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)-2,6-difluorophenyl)propan-2-ol (267); 2-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)-2,6-difluorophenyl) propan-2-ol (268); (S)-2-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)-7-fluoroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (269); (S)-2-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)-7-fluoroquinolin-6-yl)pyridin-2-yl)propan-2-ol (270); 2-(5-(3-chloro-7-fluoro-4-(((1S,2R)-2-phenylcyclopropyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (271); 1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)-2-morpholinoethan-1-ol (272); 1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrazin-2-yl)-2-morpholinoethan-1-ol (273); 1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrazin-2-yl)-2-morpholinoethan-1-ol (274); 1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrazin-2-yl)-2-morpholinoethan-1-ol (275); 1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrazin-2-yl)-2-morpholinoethan-1-ol (276); 1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)-2-morpholinoethan-1-ol (277); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)cyclopropyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (278); 2-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)cyclopropyl)amino)quinolin-6-yl)phenyl)propan-2-ol (279); (R)-2-(4-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)phenyl)piperazin-1-yl)acetic acid (280); methyl 1-(5-(3-chloro-7-fluoro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)pyrrolidine-3-carboxylate (281); 1-(5-(3-chloro-7-fluoro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)pyrrolidine-3-carboxylic acid (282); 2-(1-(5-(3-chloro-7-fluoro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)pyrrolidin-3-yl)propan-2-ol (283); 1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrazin-2-yl)pyrrolidin-3-ol (284); (R)-2-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetic acid (285); 1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)-2-morpholinoethan-1-ol (286); 4-(5-(7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)tetrahydro-2H-pyran-4-ol (287); 1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)-2-morpholinoethan-1-ol (288); 4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl)-4-hydroxytetrahydro-2H-thiopyran 1,1-dioxide (289); 1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)ethane-1,2-diol (290); 1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)ethane-1,2-diol (291); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)-1-methoxypropan-2-ol (292); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)-1-methoxypropan-2-ol (293); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrazin-2-yl)propan-2-ol (294); 4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)-4-hydroxycyclohexane-1-carboxylic acid (295); 2-(5-(3,5-dichloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (296); (S)-2-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)-8-fluoroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (297); 2-(5-(3-chloro-8-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (298); (S)-2-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)-8-fluoro-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (299); 1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)ethane-1,2-diol (300); 2-(5-(3-chloro-8-fluoro-4-((1-(4-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (301); (R)-3-(1-((3-chloro-8-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorobenzonitrile (302); (R)-3-(1-((3-chloro-8-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorobenzamide (303); (R)-(2-(4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) piperazin-1-yl)acetyl)glycine (304); (S)-2-(4-(3-chloro-4-((2,2-difluoro-1-(2-fluorophenyl)ethyl)amino)-8-fluoro-2-methylquinolin-6-yl)phenyl)propan-2-ol (305); 2-(5-(3-chloro-8-fluoro-2-methyl-4-((1-phenylethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (306); 2-(5-(3-chloro-8-fluoro-4-((1-(3-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (307); \u00b12-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)phenyl)propan-2-ol (308); 2-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl) acetic acid (309); 4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)thiomorpholine 1,1-dioxide (310); 3-chloro-N-(1-(2-fluorophenyl)ethyl)-2-methyl-6-(2-morpholinopyrimidin-5-yl)quinolin-4-amine (311); (R)-3-(1-((3-chloro-6-(4-(2-hydroxypropan-2-yl)phenyl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorobenzamide (312); (R)-3-(1-((3-chloro-2-methyl-6-(2-morpholinopyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzamide (313); (R)-4-fluoro-3-(1-((6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2,3-dimethylquinolin-4-yl)amino)ethyl)benzonitrile (314); (R)-4-fluoro-3-(1-((6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2,3-dimethylquinolin-4-yl)amino)ethyl)benzamide (315); (R)-2-(5-(4-((1-(5-bromo-2-fluorophenyl)ethyl)amino)-3-chloro-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (316); 2-(5-(3-chloro-4-((1-(2,5-difluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (317); (R)-2-(5-(4-((1-(5-bromo-2-fluorophenyl)ethyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (318); (R)-2-(5-(4-((1-(3-bromophenyl)ethyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl) propan-2-ol (319); (S)-2-(5-(4-((1-(5-bromo-2-fluorophenyl)-2,2-difluoroethyl)amino)-3-chloro-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (320); (R)-2-(5-(4-((1-(5-bromo-2-fluorophenyl)-2,2-difluoroethyl)amino)-3-chloro-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (321); (R)-2-(5-(3-chloro-2-methyl-4-((1-phenylethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (322); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(2-hydroxyethyl)phenyl)ethyl)amino)-2-methylquinolin-6-yl) pyrimidin-2-yl)propan-2-ol (323); (R)-2-(5-(3-chloro-7-fluoro-4-((1-(2-fluoro-5-(2-hydroxyethoxy)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (324); (R)-2-(5-(3-chloro-7-fluoro-4-((1-(2-fluoro-5-(2-hydroxyethyl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (325); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-methoxyphenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (326); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-methoxyphenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (327); (R)-6-bromo-3-chloro-N-(1-(2-fluoro-5-methoxyphenyl)ethyl)-2-methylquinolin-4-amine (328); (R)-3-chloro-N-(1-(2-fluoro-5-methoxyphenyl)ethyl)-2-methylquinolin-4-amine (329); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-vinylphenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (330); (R)-2-(5-(3-chloro-4-((1-(4-fluoro-[1,1\u2032-biphenyl]-3-yl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl) propan-2-ol (331); (R)-2-(5-(3-chloro-4-((1-(4-fluoro-2\u2032-methyl-[1,1\u2032-biphenyl]-3-yl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (332); (R)-2-(5-(3-chloro-4-((1-(5-(cyclopent-1-en-1-yl)-2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (333); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-methylphenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl) propan-2-ol (334); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1H-pyrazol-4-yl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl) propan-2-ol (335); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1H-pyrazol-3-yl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (336); tert-butyl (R)-4-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)-3,6-dihydropyridine-1(2H)-carboxylate (337); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1,2,3,6-tetrahydropyridin-4-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (338); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (339); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (340); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(pyrazin-2-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (341); (R)-2-(4-(5-(3-chloro-4-((1-(2-fluoro-5-(1H-pyrazol-4-yl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetic acid (342); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl) propan-2-ol (343); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (344); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(pyrimidin-2-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (345); (R)-2-(4-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)-1H-pyrazol-1-yl)acetic acid (346); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(thiazol-5-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (347); (R)-2-(5-(4-((1-(5-(6-aminopyridin-3-yl)-2-fluorophenyl)ethyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (348); (R)-1-(4-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol (349); (R)-2-(5-(4-((1-(5-(2-aminopyridin-4-yl)-2-fluorophenyl)ethyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (350); (S)-2-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluoro-5-methylphenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (351); (S)-2-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluoro-5-vinylphenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (352); 2-(5-(4-([1,1\u2032-biphenyl]-2-yl)-3-chloro-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (353); (S)-methyl 3-((S)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl) piperidine-1-carboxylate (354); tert-Butyl (R)-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenyl)carbamate (359); (R)-2-(5-(4-((1-(5-amino-2-fluorophenyl)ethyl)amino)-3-chloro-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (360); (R)-1-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenyl)pyrrolidin-2-one (361); (R)-1-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)pyrrolidin-2-one (362); (R)-1-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)phenyl)pyrrolidin-2-one (363); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(pyrrolidin-1-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (364); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1H-pyrazol-1-yl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (365); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1H-pyrazol-1-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (366); (R)-3-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)oxazolidin-2-one (367); (R)-2-(5-(4-((1-(3-(1H-pyrazol-1-yl)phenyl)ethyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (368); (R)-4-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)morpholin-3-one (369); (R)-1-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)imidazolidin-2-one (370); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(4H-1,2,4-triazol-4-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (371); (S)-1-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-2,2-difluoroethyl)-4-fluorophenyl)imidazolidin-2-one (372); (R)-1-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenyl) imidazolidin-2-one (373); (R)-2-(5-(4-((1-(5-amino-2-fluorophenyl)ethyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (374); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorobenzonitrile (375); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzonitrile (376); (R)-2-(4-(5-(3-chloro-4-((1-(5-cyano-2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl) piperazin-1-yl)acetic acid (377); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzonitrile (378); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzonitrile (379); (S)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzonitrile (380); (S)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzonitrile (381); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl quinolin-4-yl)amino)ethyl)-4-fluorobenzonitrile (382); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)benzonitrile (383); ethyl (R)-3-chloro-4-((1-(5-cyano-2-fluorophenyl)ethyl)amino)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinoline-2-carboxylate (384); (R)-3-chloro-4-((1-(5-cyano-2-fluorophenyl)ethyl)amino)-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-N-(pyridin-3-yl)quinoline-2-carboxamide (385); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)benzonitrile (386); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorobenzamide (387); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzamide (388); (R)-2-(4-(5-(4-((1-(5-carbamoyl-2-fluorophenyl)ethyl)amino)-3-chloro-2-methylquinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)acetic acid (389); (S)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzamide (390); (S)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzamide (391); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzamide (392); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl) pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorobenzamide (393); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)benzamide (394); (R)-4-((1-(5-carbamoyl-2-fluorophenyl)ethyl)amino)-3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-N-(pyridin-3-yl)quinoline-2-carboxamide (395); (R)-2-(5-(4-((1-(5-benzyl-2-fluorophenyl)ethyl)amino)-3-chloro-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (396); 1-(3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenyl)ethane-1,2-diol (397); 1-(3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)ethane-1,2-diol (398); 3-(3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)propane-1,2-diol (399); 1-(3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)ethane-1,2-diol (400); 1-(3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl) ethane-1,2-diol (401); 1-(3-((S)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-2,2-difluoroethyl)-4-fluorophenyl)ethane-1,2-diol (402); 2-(3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenyl)propane-1,2-diol (403); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenol (404); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenol (405); (R)-2-(5-(3-chloro-4-((1-(5-chloro-2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (406); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorobenzoic acid (407); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(2-hydroxypropan-2-yl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol, TFA salt (408); (R)-1-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)ethan-1-one (409); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(2-hydroxypropan-2-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (410); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(phenylethynyl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (411); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1H-tetrazol-5-yl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (412); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(2-methyl-2H-tetrazol-5-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (413); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1H-1,2,4-triazol-5-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (414); Methyl (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzoate (415); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluoro-N-methylbenzamide (416); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluoro-N,N-dimethylbenzamide (417); (S)-2-(5-(3-chloro-4-((2,2-difluoro-1-(2-fluoro-5-(2-hydroxypropan-2-yl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (418); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1H-1,2,3-triazol-4-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (419); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1-methyl-1H-1,2,3-triazol-4-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (420); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(1-methyl-1H-1,2,3-triazol-5-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (421); 5-(3-((R)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)imidazolidine-2,4-dione (422 and 423); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzaldehyde oxime (424); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(methylsulfonyl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (425); (R)-3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzenesulfonamide (426); Methyl (R)-3-((3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)sulfonyl)propanoate (427); (R)-3-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorophenyl)-1H-pyrazole-5-carboxylic acid (428); (R)-2-(5-(4-((1-(5-(aminomethyl)-2-fluorophenyl)ethyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (429); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(hydroxymethyl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (430); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(hydroxymethyl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (431); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(hydroxymethyl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)-4,5-dihydropyrimidin-2-yl)propan-2-ol (432); 2-(5-(3-chloro-4-(((1R)-1-(2-fluoro-5-(1-hydroxyethyl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (433); 2-(5-(4-(((1S)-1-(5-(1-amino-2-hydroxyethyl)-2-fluorophenyl)-2,2-difluoroethyl)amino)-3-chloro-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (434); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(2-hydroxyethoxy)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (435); (R)-2-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenyl)acetic acid (436); (R)-2-(5-(3-chloro-4-((1-(3-(2-hydroxyethoxy)phenyl)ethyl) amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (437); (R)-2-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)phenoxy)acetic acid (438); (R)-2-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenoxy)acetic acid (439); (R)-2-(5-(3-chloro-7-fluoro-4-((1-(2-fluoro-5-(2-hydroxyethoxy)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (440); (R)-2-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (441); (R)-2-(5-(3-chloro-7-fluoro-4-((1-(2-fluoro-5-(2-hydroxyethyl)phenyl)ethyl)amino)-2-methylquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (442); (R)-3-(3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenoxy)propan-1-ol (443); (R)-3-(3-(1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenoxy)propan-1-ol (444); (R)-3-(3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenyl) propanamide (445); (R)-3-(3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenyl)propanoic acid (446); (R)-3-(1-((3-chloro-2-methyl-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzamide (447); (R)-3-(1-((3-chloro-7-fluoro-2-methyl-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzamide (448); (R)-5-(4-((1-(5-bromo-2-fluorophenyl)ethyl)amino)-3-chloro-7-fluoro-2-methylquinolin-6-yl)pyridin-2(1H)-one (449); (R)-3-(1-((3-chloro-7-fluoro-2-methyl-6-(6-oxo-1,6-dihydropyridin-3-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzonitrile (450); (R)-3-chloro-N-(1-(2-fluoro-5-methoxyphenyl)ethyl)quinolin-4-amine (451); (R)-N-(1-(5-allyl-2-fluorophenyl)ethyl)-3-chloroquinolin-4-amine (452); 3-chloro-N-(1-(2-fluorophenyl)propyl) quinolin-4-amine (453); (R)-3-chloro-N-(1-(2-fluoro-5-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl) quinolin-4-amine (454); (R)-3-chloro-N-(1-(2-fluoro-5-(1H-pyrazol-4-yl)phenyl)ethyl)quinolin-4-amine (455); (R)-N-(1-(5-(allyloxy)-2-fluorophenyl)ethyl)-3-chloroquinolin-4-amine (457); (R)-3-(3-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4-fluorophenoxy)propan-1-ol (458); (R)-3-chloro-N-(1-(4-fluoro-[1,1\u2032-biphenyl]-3-yl)ethyl)quinolin-4-amine (459); (R)-3-chloro-N-(1-(2-fluoro-5-(6-methoxypyridin-3-yl)phenyl)ethyl)quinolin-4-amine (460); (R)-3-chloro-N-(1-(2-fluoro-5-(pyridin-3-yl)phenyl)ethyl)quinolin-4-amine (461); (R)-3-chloro-N-(1-(3-methoxyphenyl)ethyl)quinolin-4-amine (462); 3-chloro-N-(1-(2-(trifluoromethyl)phenyl)ethyl)quinolin-4-amine (463); (R)-3-(3-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4-fluorophenyl)propan-1-ol (464); (R)-1-(4-(3-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4-fluorophenyl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol (465); (R)-N-(1-(5-(1-benzyl-1H-pyrazol-4-yl)-2-fluorophenyl)ethyl)-3-chloroquinolin-4-amine (466); (R)-3-chloro-N-(1-(2-fluoro-5-(2-morpholinopyrimidin-5-yl)phenyl)ethyl)quinolin-4-amine (467); (R)-3-chloro-N-(1-(2-fluoro-5-(pyridin-4-yl)phenyl)ethyl)quinolin-4-amine (468); (R)-2-(5-(3-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4-fluorophenyl)pyrimidin-2-yl)propan-2-ol (469); N-(5-bromo-2-methylphenyl)-3-chloro-2-methylquinolin-4-amine (470); (R)-3-chloro-N-(1-(5-(1-(difluoromethyl)-1H-pyrazol-4-yl)-2-fluorophenyl)ethyl)quinolin-4-amine (471); (R)-3-chloro-N-(1-(2-fluoro-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)phenyl)ethyl)quinolin-4-amine (472); (R)-3-chloro-N-(1-(5-(1-ethyl-1H-pyrazol-4-yl)-2-fluorophenyl)ethyl)quinolin-4-amine (473); (R)-3-chloro-N-(1-(5-(1,5-dimethyl-1H-pyrazol-4-yl)-2-fluorophenyl)ethyl)quinolin-4-amine (474); (R)-3-chloro-N-(1-(2-fluoro-5-(2-methylpyridin-3-yl)phenyl)ethyl)quinolin-4-amine (475); (S)-3-chloro-N-(1-(2-fluoro-5-methoxyphenyl)ethyl)quinolin-4-amine (476); (R)-3-chloro-N-(1-(2-fluoro-5-(6-methylpyridazin-4-yl)phenyl)ethyl)quinolin-4-amine (477); (R)-N-(1-(5-(6-aminopyridin-3-yl)-2-fluorophenyl)ethyl)-3-chloroquinolin-4-amine (478); (R)-3-chloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)quinolin-4-amine (479); (R)-3-chloro-N-(1-(2-fluoro-5-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)phenyl)ethyl) quinolin-4-amine (480); (R)-N-(1-(5-(2-aminopyrimidin-5-yl)-2-fluorophenyl)ethyl)-3-chloroquinolin-4-amine (481); N-(1-(4-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)-2-hydroxyethyl)acetamide (482); (R)-1-(1-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)cyclobutyl)urea (483); 4-(5-(3-chloro-4-((1-(3-fluoro-6-methylpyridin-2-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-2-one (484); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzoic acid (485); (R)-2-(5-(7-chloro-8-((2,2-difluoro-1-(2-fluoro-5-(hydroxymethyl)phenyl)ethyl)amino)-3-fluoro-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (486); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzamide (487); 1-(3-((R)-1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorophenyl)ethane-1,2-diol (488); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzonitrile (489); (R)-2-(4-(3-chloro-4-((1-(pyrazin-2-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (490); 1-(3-((S)-1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorophenyl)ethane-1,2-diol (491); 1-(3-((S)-1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorophenyl)ethane-1,2-diol (492); (S)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzamide (493); (S)-2-(5-(7-chloro-8-((2,2-difluoro-1-(2-fluoro-5-vinylphenyl)ethyl)amino)-3-fluoro-6-methyl-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (494); (S)-2-(5-(7-chloro-8-((2,2-difluoro-1-(2-fluoro-5-vinylphenyl)ethyl)amino)-3-fluoro-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (495); (S)-2-(5-(7-chloro-8-((2,2-difluoro-1-(2-fluoro-5-(hydroxymethyl)phenyl)ethyl)amino)-3-fluoro-6-methyl-1,5-naphthyridin-2-yl)pyrimidin-2-yl) propan-2-ol (496); (S)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzamide (497); (S)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzonitrile (498); (S)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1,5-naphthyridin-4-yl)amino)-2,2-difluoroethyl)-4-fluorobenzonitrile (499); (R)-2-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)-2-methylquinolin-6-yl)phenyl)propan-2-ol (500); (S)-2-(5-(7-chloro-8-((2,2-difluoro-1-(2-fluoro-5-(hydroxymethyl)phenyl)ethyl)amino)-3-fluoro-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (501); 2-(4-(3-chloro-2-methyl-4-((1-(thiophen-2-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (502); 2-(4-(3-chloro-2-methyl-4-((1-(thiophen-3-yl)ethyl)amino)quinolin-6-yl)phenyl)propan-2-ol (503); 1-(3-((R)-1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)ethyl)-4-fluorophenyl) ethane-1,2-diol (504); (R)-2-(5-(7-chloro-3-fluoro-8-((1-(2-fluoro-5-(hydroxymethyl)phenyl)ethyl)amino)-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (505); (R)-3-chloro-N-(1-(5-(6-(dimethylamino)pyridin-3-yl)-2-fluorophenyl)ethyl)quinolin-4-amine (506); (R)-3-chloro-N-(1-(2-fluoro-5-(5-methylpyridin-3-yl)phenyl)ethyl)quinolin-4-amine (507); (R)-3-chloro-N-(1-(5-(6-ethylpyridin-3-yl)-2-fluorophenyl)ethyl)quinolin-4-amine (508); (S)-N-(1-(5-bromo-2-fluorophenyl)-2,2-difluoroethyl)-3-chloroquinolin-4-amine (509); (R)-N-(1-(5-bromo-2-fluorophenyl)-2,2-difluoroethyl)-3-chloroquinolin-4-amine (510); (R)-N-(1-(5-(5-aminopyridin-3-yl)-2-fluorophenyl)ethyl)-3-chloroquinolin-4-amine (511); (R)-N-(1-(5-(2-aminopyridin-3-yl)-2-fluorophenyl)ethyl)-3-chloroquinolin-4-amine (512); (R)-3-chloro-N-(1-(5-(3,6-dimethoxypyridazin-4-yl)-2-fluorophenyl)ethyl)quinolin-4-amine (513); (R)-5-(3-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4-fluorophenyl)picolinonitrile (514); (R)-3-chloro-N-(1-(2-fluoro-5-(pyridazin-4-yl)phenyl)ethyl)quinolin-4-amine (515); N-(5-bromo-2-fluorobenzyl)-3-chloroquinolin-4-amine (516); 3-chloro-N-(2-fluoro-5-methoxybenzyl)quinolin-4-amine (517); (R)-3-chloro-N-(1-(2-fluoro-5-(6-methylpyridin-3-yl)phenyl)ethyl)quinolin-4-amine (518); (R)-3-chloro-N-(1-(5-(2-cyclopropylpyrimidin-5-yl)-2-fluorophenyl)ethyl)quinolin-4-amine (519); (R)-5-(3-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4-fluorophenyl)-2-methoxynicotinonitrile (520); (R)-N-(1-(5-(5-amino-6-methoxypyridin-3-yl)-2-fluorophenyl)ethyl)-3-chloroquinolin-4-amine (521); (R)-3-chloro-N-(1-(2-fluoro-5-(5-methoxypyridin-3-yl)phenyl)ethyl)quinolin-4-amine (522); (R)-3-chloro-N-(1-(2-fluoro-5-(4-(methylamino)pyridin-3-yl)phenyl)ethyl)quinolin-4-amine (523); (R)-3-chloro-N-(1-(2-fluoro-5-(1-methyl-1H-imidazol-5-yl)phenyl)ethyl)quinolin-4-amine (524); (R)-3-chloro-N-(1-(2-fluoro-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)ethyl)quinolin-4-amine (525); (R)-N-(1-(3\u2032-amino-4-fluoro-[1,1\u2032-biphenyl]-3-yl)ethyl)-3-chloroquinolin-4-amine (526); (R)-3-chloro-N-(1-(2-fluoro-5-(5-fluoro-2-methoxypyridin-4-yl)phenyl)ethyl)quinolin-4-amine (527); (R)-3-chloro-N-(1-(2-fluoro-5-(1H-indol-2-yl)phenyl)ethyl)quinolin-4-amine (528); (R)-3-chloro-N-(1-(2-fluoro-5-(4-methylpyridin-3-yl)phenyl)ethyl)quinolin-4-amine (529); (R)-3-chloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)-2-methylquinolin-4-amine (530); (R)-3-chloro-N-(1-(2-fluoro-5-(pyridin-3-yl)phenyl)ethyl)-2-methylquinolin-4-amine (531); (R)-6-bromo-3-chloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)quinolin-4-amine (532); (R)-3-chloro-N-(1-(2-fluoro-5-(1H-pyrazol-4-yl)phenyl)ethyl)-2-methylquinolin-4-amine (533); (R)-3-chloro-N-(1-(2-fluoro-5-(2-methylpyrimidin-5-yl)phenyl)ethyl)-2-methylquinolin-4-amine (534); (R)-3-chloro-N-(1-(2-fluoro-5-(2-methylpyrimidin-5-yl)phenyl)ethyl)quinolin-4-amine (535); (R)-3-chloro-N-(1-(5-(2-(dimethylamino)pyrimidin-5-yl)-2-fluorophenyl)ethyl)quinolin-4-amine (536); (R)-3-chloro-N-(1-(2-fluoro-5-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)ethyl)quinolin-4-amine (537); (R)-N-(1-(5-bromo-2-fluorophenyl)ethyl)-3-chloro-2-methylquinolin-4-amine (538); (R)-3\u2032-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4\u2032-fluoro-[1,1\u2032-biphenyl]-3-carbonitrile (539); (R)-3-chloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)-6-(pyridin-4-yl)quinolin-4-amine (540); (R)-5-(3-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4-fluorophenyl)nicotinonitrile (541); (R)-3-chloro-N-(1-(2-fluoro-5-(thiazol-5-yl)phenyl)ethyl) quinolin-4-amine (542); (R)-3-chloro-N-(1-(2-fluoro-5-(2-methoxypyrimidin-5-yl)phenyl)ethyl) quinolin-4-amine (543); (R)-3-chloro-6-fluoro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl) quinolin-4-amine (544); (R)-3,6-dichloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)quinolin-4-amine (545); (R)-6-bromo-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)quinolin-4-amine (546); (R)-N-(1-(2\u2032-amino-4-fluoro-[1,1\u2032-biphenyl]-3-yl)ethyl)-3-chloroquinolin-4-amine (547); (R)-3-chloro-N-(1-(2-fluoro-5-(4-methoxypyridin-3-yl)phenyl)ethyl)quinolin-4-amine (548); (R)-3-chloro-N-(1-(4-fluoro-2\u2032-methoxy-[1,1\u2032-biphenyl]-3-yl)ethyl)quinolin-4-amine (549); (R)-3-chloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)quinolin-4-amine (550); (R)-(5-(3-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4-fluorophenyl)pyridin-3-yl)(morpholino)methanone (551); (R)-3\u2032-(1-((3-chloroquinolin-4-yl)amino)ethyl)-4\u2032-fluoro-[1,1\u2032-biphenyl]-2-carbonitrile (552); (R)-2-(5-(3-chloro-4-((1-(2-fluoro-5-(pyridin-3-yl)phenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (553); (R)-2-(3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methylquinolin-4-yl)amino)ethyl)-4-fluorophenyl)acetamide (554); (R)-3-chloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)-1,5-naphthyridin-4-amine (555); (R)-3-chloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)-2-methyl-1,8-naphthyridin-4-amine (556); (S)-3-chloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)propyl)quinolin-4-amine (557); (R)-3-chloro-N-(1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)propyl)quinolin-4-amine (558); (S)-3-chloro-N-(2,2-difluoro-1-(2-fluoro-5-(pyrimidin-5-yl)phenyl)ethyl)quinolin-4-amine (559); (R)-4-(5-(4-((1-(5-bromo-2-fluorophenyl)ethyl)amino)-3-chloro-7-fluoro-2-methylquinolin-6-yl)pyrimidin-2-yl)piperazin-2-one (560); (R)-3-(1-((3-chloro-7-fluoro-2-methyl-6-(2-(3-oxopiperazin-1-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)-4-fluorobenzonitrile (561); 4-(5-(4-((1-(6-amino-3-fluoropyridin-2-yl)ethyl)amino)-3-chloroquinolin-6-yl)pyrimidin-2-yl)piperazin-2-one (562); 2-(5-(3-chloro-4-(((S)-1-((S)-1-(methylsulfonyl)piperidin-3-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (563); 2-(5-(3-chloro-4-(((S)-1-((S)-1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)piperidin-3-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (564); ((S)-3-((S)-1-((3-chloro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)quinolin-4-yl)amino)ethyl)piperidin-1-yl)(1H-pyrazol-4-yl)methanone (565); 2-(5-(3-chloro-4-(((S)-1-((S)-1-(pyrimidin-5-yl)piperidin-3-yl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) propan-2-ol (567); (R)-2-((1-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)cyclobutyl)amino)ethan-1-ol (568); (R)-1-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)benzyl)urea (569); 1-(3-((R)-1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1,5-naphthyridin-4-yl)amino)ethyl)-4-fluorophenyl)ethane-1,2-diol (570); (R)-2-(5-(7-chloro-3-fluoro-6-methyl-8-((1-(3-vinylphenyl)ethyl)amino)-1,5-naphthyridin-2-yl)pyrimidin-2-yl) propan-2-ol (571); (R)-2-(5-(7-chloro-3-fluoro-8-((1-(2-fluoro-5-vinylphenyl)ethyl)amino)-6-methyl-1,5-naphthyridin-2-yl)pyrimidin-2-yl)propan-2-ol (572); (R)-1-((5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)amino)cyclopropane-1-carboxamide (587); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)ethyl)benzonitrile (588); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-2-methyl-1,5-naphthyridin-4-yl)amino)ethyl)benzonitrile (589); (R)-3-(1-((3-chloro-7-fluoro-6-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-1,5-naphthyridin-4-yl)amino)ethyl)-4-fluorobenzonitrile (590); 2-((5-(3-chloro-4-(((R)-1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)amino)propanamide (591); N-(2-(4-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)phenyl)propan-2-yl)acetamide (592); (R)-2-(4-(5-(3-chloro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperidin-1-yl)acetic acid (593); (R)-2-(4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperidin-1-yl)acetic acid (594); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrazin-2-yl) propan-2-ol (595); 1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)ethane-1,2-diol (596); 1-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino) quinolin-6-yl)pyrimidin-2-yl)ethane-1,2-diol (597); 3-chloro-7-fluoro-N-(1-(2-fluorophenyl)ethyl)-6-(4-(morpholin-3-yl)phenyl)quinolin-4-amine (598); 3-(1-((3-chloro-6-(4-(1,2-dihydroxyethyl)phenyl)-7-fluoroquinolin-4-yl)amino)ethyl)-4-fluorobenzonitrile (599); 1-(4-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)phenyl)-2-(methylamino)ethan-1-ol (600); 3-(1-((3-chloro-6-(4-(1,2-dihydroxyethyl)phenyl)-7-fluoroquinolin-4-yl)amino)ethyl)-4-fluorobenzamide (601); 4-(4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) piperazin-1-yl)-4-oxobutanoic acid (602); 1-(4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)-2-hydroxypropan-1-one (603); (2S)-2-amino-1-(4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)-3-hydroxypropan-1-one (604); (3 S)-3-amino-4-(4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)-4-oxobutanoic acid (605); (2R)-2-amino-1-(4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl) piperazin-1-yl)-3-hydroxypropan-1-one (606); (3R)-3-amino-4-(4-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)piperazin-1-yl)-4-oxobutanoic acid (607); 3-chloro-7-fluoro-N-(1-(2-fluorophenyl)ethyl)-6-(2-(piperazin-1-yl)pyrimidin-5-yl)quinolin-4-amine (608); 2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)cyclobutyl)amino)quinolin-6-yl)pyrimidin-2-yl)propan-2-ol (609); 1-(2-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl) pyrimidin-2-yl)-2-hydroxyethyl)piperidine-4-carboxylic acid (610); (1R,5S,8r)-3-(5-(3-chloro-7-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)quinolin-6-yl)pyrimidin-2-yl)-3-azabicyclo[3.2.1]octane-8-carboxylic acid (611); or 2-(5-(4-((1-(5-bromo-2-fluorophenyl)ethyl)amino)-3-chloro-8-fluoroquinolin-6-yl)pyrimidin-2-yl)propan-2-ol (612).

Metadata:
- Claim Count in Document: 3.0
- Percentile: 88.0
- Lexical Diversity: 2.06897
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15749611', '15558692', '15558708', '15558724', '14588470']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8417942034556745
- 35 USC 102 Novelty (BERT): 0.5652559108658134
- Combined Prediction Score: 0.8141403741966884
- Mean Citation Score: 430.14112400000016
- Max Citation Score: 456.6969
- Similarity Product: 402.3873356276751

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test