PATENT CLAIM ANALYSIS

Application Number: 15759465
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["424", "489000"]

Abstract:
Improved distribution can be achieved by delivering nanoparticles possessing non-adhesive surfaces via CED in a hyperosmolar infusate solution. This delivery strategy minimizes the hindrances imposed by the brain extracellular matrix and reduces the concentration of therapeutic that is confined within perivascular spaces.

Claim (Index 1):
A composition for delivery of nanoparticles to tissues including brain, the composition comprising\n (i) a hyperosmolar solution; and (ii) a nanoparticle; the nanoparticle comprising a first polymer, and\n a second hydrophilic, neutrally charged polymer, linked to the first polymer to form a conjugate; \n wherein, the second hydrophilic and neutrally charged polymer coats the surface of the nanoparticle, and wherein the concentration of the hyperosmolar solution and the density of the hydrophilic, neutrally charged polymer coating enhance the diffusion and distribution of the nanoparticles within tissues.

Metadata:
- Claim Count in Document: 41.0
- Percentile: 90.0
- Lexical Diversity: 1.1
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15310535', '15914796', '15310643', '13821320', '14726770']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7149179049510538
- 35 USC 102 Novelty (BERT): 0.5022155101465968
- Combined Prediction Score: 0.6936476654706081
- Mean Citation Score: 245.921522
- Max Citation Score: 288.205
- Similarity Product: 243.45486558258528

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test