PATENT CLAIM ANALYSIS

Application Number: 15909096
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "006100"]

Abstract:
Fluorescence quenching nitrodiarylethene analogs are useful in oligonucleotide conjugates and probes. These analogs, whose absorption spectra are substantially blue-shifted relatively to emission spectra of common fluorophores (such as fluorescein), do not need to rely on spectral overlap of quencher absorbance and fluorophore's emission for their quenching abilities. The oligonucleotide-quencher conjugates may be used in detection methods for nucleic acid targets.

Claim (Index 1):
A quencher reagent for oligonucleotide labeling having the formula:\n (R 1 )(R 2 )Y\u2014Ar 1 \u2014(\u2014CR 3 \u2550CR 4 \u2014Ar 2 ) n  wherein Ar 1  and Ar 2  each independently represent a substituted or unsubstituted aryl or heteroaryl group and at least one of Ar 1  and Ar 2  is substituted with one NO 2  group; R 3  and R 4  are independently H or (C 1 -C 8 ) alkyl; n is from 1 to 3; Y is a linking group connecting Ar 1  with R 1  and R 2  and having from 0 to 100 main chain atoms selected from C, N, O, S, P and Si, wherein Y can include acyclic, cyclic, or aromatic groups, or combinations thereof; R 1  is a protected or unprotected functional group or a linking group for attachment to a solid support; and R 2  is H, (C 1 -C 12 )alkyl, aryl, heteroaryl, or a protected or unprotected functional group.

Metadata:
- Claim Count in Document: 75.0
- Percentile: 90.0
- Lexical Diversity: 1.25926
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['12683326', '11338866', '10976365', '12047101', '13383135']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6320231323317947
- 35 USC 102 Novelty (BERT): 0.5577032062001469
- Combined Prediction Score: 0.6245911397186299
- Mean Citation Score: 366.618246
- Max Citation Score: 431.7884
- Similarity Product: 333.43070352578167

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test