PATENT CLAIM ANALYSIS

Application Number: 15756591
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-06
Patent Classification: ["514", "036000"]

Abstract:
Novel pseudo-trisaccharide aminoglycosides, represented by Formula I, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.

Claim (Index 1):
A compound represented by general Formula I: or a pharmaceutically acceptable salt thereof, wherein:\n the dashed lines indicates a stereo-configuration of position 6\u2032 being an R configuration or an S configuration; \n R 1  is selected from hydrogen, alkyl, cycloalkyl or aryl; \n R 2  is selected from a substituted or unsubstituted alkyl, OR\u2032 and NR\u2032R\u2033, wherein each of R\u2032 and R\u2033 is independently selected from hydrogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted alkaryl, and an acyl; \n R 4  is selected from hydrogen, acyl, an amino-substituted alpha-hydroxy acyl, a substituted or unsubstituted alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted alkaryl, and a cell-permealizable group; \n R 5  and R 6  are each independently selected from hydrogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted alkaryl, a substituted or unsubstituted heteroaryl, acyl, and a cell-permealizable group, or, alternatively, R 5  and R 6  form together a heterocyclic ring; and \n R 7  is alkyl, cycloalkyl or aryl, \n provided that: \n when R 2  is hydroxy, R 4  is not hydrogen, AHB or AHP, and/or at least one of R 5  and/or R 6 , if present, is not hydrogen.

Metadata:
- Claim Count in Document: 65.0
- Percentile: 90.0
- Lexical Diversity: 1.42857
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15453990', '14866960', '13885715', '14461477', '10625059']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8029589790365734
- 35 USC 102 Novelty (BERT): 0.5165713943139499
- Combined Prediction Score: 0.7743202205643112
- Mean Citation Score: 310.667372
- Max Citation Score: 319.7449
- Similarity Product: 267.1483129892349

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test