PATENT CLAIM ANALYSIS

Application Number: 15971233
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-08
Patent Classification: ["514", "054000"]

Abstract:
The present invention relates to a process for the enzymatic modification of a glycoprotein. The process comprises the step of contacting a glycoprotein comprising a glycan comprising a terminal GlcNAc-moiety, in the presence of glycosyltransferase that is, or is derived from, a β-(1,4)-N-acetylgalactosaminyltransferase, with a non-natural sugar-derivative nucleotide. The non-natural sugar-derivative nucleotide is according to formula (3): wherein A is selected from the group consisting of —N 3 , —C(O)R 3 , —(CH 2 ) i C≡C—R 4 , —SH, —SC(O)R 8 , —SC(O)OR 8 , —SC(S)OR 8 , —F, —Cl, —Br —I, —OS(O) 2 R 5 , terminal C 2 -C 24  alkenyl groups, C 3 -C 5  cycloalkenyl groups, C 4 -C 8  alkadienyl groups, terminal C 3 -C 24  allenyl groups and amino groups. The invention further relates to a glycoprotein obtainable by the process according to the invention, to a bioconjugate that can be obtained by conjugating the glycoprotein with a linker-conjugate, and to β-(1,4)-N-acetylgalactosaminyltransferases that can be used in preparing the glycoprotein according to the invention.

Claim (Index 3):
The bioconjugate according to  claim 1 , wherein D is a cytotoxin.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 93.0
- Lexical Diversity: 2.41758
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15318248', '15029123', '15028874', '14807503', '12840529']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7797732534573666
- 35 USC 102 Novelty (BERT): 0.557999435163234
- Combined Prediction Score: 0.7575958716279534
- Mean Citation Score: 304.351574
- Max Citation Score: 433.21313
- Similarity Product: 344.4932715906805

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test