PATENT CLAIM ANALYSIS

Application Number: 15886559
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-08
Patent Classification: ["540", "560000"]

Abstract:
The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).

Claim (Index 23):
A method of treating a condition in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of formula III: wherein X is N or CR 5 ;\n R 5  is H, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each of which is optionally substituted; \n R B  is H, alkyl, hydroxylalkyl, aminoalkyl, alkoxyalkyl, haloalkyl, hydroxy, alkoxy, or \u2014COO\u2014R 3 , each of which is optionally substituted; \n ring A is aryl or heteroaryl;\n each R A  is independently alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each of which is optionally substituted; or any two R A  together with the atoms to which each is attached, can form a fused aryl or heteroaryl group; \n R is alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each of which is optionally substituted; \n each R 3  is independently selected from the group consisting of: \n (i) H, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; \n (ii) heterocycloalkyl or substituted heterocycloalkyl; \n (iii) \u2014C 1 -C 8  alkyl, \u2014C 2 -C 8  alkenyl or \u2014C 2 -C 8  alkynyl, each containing 0, 1, 2, or 3 heteroatoms selected from O, S, or N; \u2014C 3 -C 12  cycloalkyl, substituted \u2014C 3 -C 12  cycloalkyl, \u2014C 3 -C 12  cycloalkenyl, or substituted \u2014C 3 -C 12  cycloalkenyl, each of which may be optionally substituted; and \n (iv) NH 2 , N\u2550CR 4 R 6 ; \n each R 4  is independently H, alkyl, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each of which is optionally substituted; \n or R 3  and R 4  are taken together with the nitrogen atom to which they are attached to form a 4-10-membered ring; \n R 6  is alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl, or heteroaryl, each of which is optionally substituted; or R 4  and R 6  are taken together with the carbon atom to which they are attached to form a 4-10-membered ring; \n m is 0, 1, 2, or 3;\n provided that: \n (a) if ring A is thienyl, X is N, R is phenyl or substituted phenyl, R B  is methyl, then R 3  and R 4  are not taken together with the nitrogen atom to which they are attached to form a morpholino ring; and \n (b) if ring A is thienyl, X is N, R is substituted phenyl, R 2  is H, R B  is methyl, and one of R 3  and R 4  is H, then the other of R 3  and R 4  is not methyl, hydroxyethyl, alkoxy, phenyl, substituted phenyl, pyridyl or substituted pyridyl; and \n or a salt, solvate or hydrate thereof, wherein the condition is selected from ovarian cancer, Ewing's sarcoma, medulloblastoma, mesothelioma, pancreatic cancer, small cell lung cancer, or melanoma.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.41026
- Patent Class: 540.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14502840', '13698010', '14977343', '13698006', '14907339']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6790005779100661
- 35 USC 102 Novelty (BERT): 0.6062536537178218
- Combined Prediction Score: 0.6717258854908417
- Mean Citation Score: 450.696202
- Max Citation Score: 547.6293
- Similarity Product: 453.4839708375692

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test