PATENT CLAIM ANALYSIS

Application Number: 16176352
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-08
Patent Classification: ["424", "001730"]

Abstract:
The present invention provides an in vivo imaging method that facilitates the diagnosis of Acute Lymphoblastic Leukemia (ALL) at an early stage. Early diagnosis is particularly advantageous as a tool to select more aggressive therapy, to estimate the success rate for visualizing ALL at the time of diagnosis.

Claim (Index 21):
A method for determining the presence of, or susceptibility to, Acute Lymphoblastic Leukemia (ALL) in a mammalian subject with an in vivo imaging agent including an in vivo imaging moiety comprising a radiolabeled 3\u2032 substituted nucleoside analog, the method comprising the steps of:\n (i) administering to said mammalian subject a detectable quantity of said in vivo imaging agent that incliudes the in vivo imaging moiety comprising the 3\u2032 substituted nucleoside analog; \n (ii) allowing said administered in vivo imaging agent of step (i) to enter cells and become phosphorylated by human thymidine kinase 1, wherein the 3\u2032 substitution of said nucleoside analog prevents further incorporation into DNA of said subject; \n (iii) detecting signals emitted by said in vivo imaging agent of step (ii) that has entered said cells and has become phosphorylated using an in vivo imaging method; \n (iv) generating an image representative of the location and/or amount of said signals; and, \n (v) using the image generated in step (iv) to determine of the presence of, or susceptibility to, ALL.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 97.0
- Lexical Diversity: 1.23256
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12234478', '11629607', '12448102', '14119539', '13596632']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6792880274858158
- 35 USC 102 Novelty (BERT): 0.4717709103142922
- Combined Prediction Score: 0.6585363157686634
- Mean Citation Score: 129.044966
- Max Citation Score: 130.87474
- Similarity Product: 91.55733680750252

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test