PATENT CLAIM ANALYSIS

Application Number: 15760783
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-02
Patent Classification: ["435", "007100"]

Abstract:
Disclosed are biomarkers for Parkinson's disease (PD), including idiopathic PD (idPD). The present invention relates generally to assays, kits, compositions, solid supports and methods that measure a decrease in the expression or function of PLA2g6(L) variant of PLA2g6 (PARK 14) gene in a sample from the subject, including non-neuronal cells as a biomarker for preclinical (prodromal) or early stage Parkinson's disease (PD) and idiopathic PD (idPD), as well as assays, kits, compositions and methods that can detect the functional consequences of decreased expression of PLA2g6(L), including decreased store operated Ca2+ entry (SOCE), deficit of Ca2+ in endoplasmic reticulum stores, and autophagic dysfunction in the cells obtained from the subjects in preclinical (prodromal) and early stage PD diagnosis and for monitoring Parkinson's Disease progression.

Claim (Index 9):
The assay of  claim 1 , wherein anti-PLA2g6(L) antibody is selected from:\n (i) an anti-PLA2g6(L) antibody that binds to an epitope at least partially encoded by exon 8b of PLA2g6(L), but is spliced out in PLA2g6(S); (ii) an anti-PLA2g6(L) antibody that binds to an epitope at least partially located in any one of SEQ ID NO: 16, SEQ ID NO: 17 or SEQ ID NO:18.

Metadata:
- Claim Count in Document: 58.0
- Percentile: 90.0
- Lexical Diversity: 2.0641
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15464047', '14213359', '14654998', '13307485', '12279871']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5817986783743285
- 35 USC 102 Novelty (BERT): 0.5436510350408637
- Combined Prediction Score: 0.5779839140409821
- Mean Citation Score: 273.53267800000003
- Max Citation Score: 386.2139
- Similarity Product: 244.29320328742267

Labels:
- Claim Label 101: 0
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test