PATENT CLAIM ANALYSIS

Application Number: 15999505
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-08
Patent Classification: ["504", "116100"]

Abstract:
The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Claim (Index 1):
A compound of formula I: or a pharmaceutically acceptable salt or agriculturally acceptable salt thereof, wherein: X is \u2014O\u2014, \u2014S\u2014, or \u2014NR\u2014; R 1  is hydrogen, C 1-4  aliphatic optionally substituted with 1-4 halogen, \u2014OR, \u2014SR, \u2014N(R) 2 , \u2014N(R)C(O)R, \u2014C(O)N(R) 2 , \u2014N(R)C(O)N(R) 2 , \u2014N(R)C(O)OR, \u2014OC(O)N(R) 2 , \u2014N(R)S(O) 2 R, \u2014S(O) 2 N(R) 2 , \u2014C(O)R, \u2014C(O)OR, \u2014OC(O)R, \u2014S(O)R, or \u2014S(O) 2 R; each instance of R 2 , R 6 , R 7 , and R 8  is independently oxo; halogen; \u2014CN; \u2014OR; \u2014R a , \u2014SR; \u2014N(R) 2 ; \u2014N(R)C(O)R; \u2014C(O)N(R) 2 ; \u2014N(R)C(O)N(R) 2 ; \u2014N(R)C(O)OR; \u2014OC(O)N(R) 2 ; \u2014N(R)S(O) 2 R; \u2014S(O) 2 N(R) 2 ; \u2014C(O)R; \u2014C(O)OR; \u2014OC(O)R; \u2014S(O)R; or \u2014S(O) 2 R; each R is independently hydrogen or R a ; each R a  is independently an optionally substituted group selected from C 1-6  aliphatic, a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; L 1  is a covalent bond; a 1-6 membered straight or branched bivalent hydrocarbon chain; cyclopropylenyl; cyclobutylenyl; or oxetanylenyl; L 2  is a covalent bond or a 1-6 membered straight or branched bivalent hydrocarbon chain; wherein L 2  is substituted by n instances of R 9 ; R 3  is \u2014OR, \u2014C(O)OR, \u2014N(R)C(O)OR, \u2014OC(O)N(R) 2 , \u2014C(O)N(R)OR, \u2014C(O)NH 2 , \u2014C(O)NHR a , C(O)N(R a ) 2 , or \u2014C(O)Hy; Hy is a 3-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein Hy is substituted by p instances of R 6 ; R 4  is selected from a 3-8 membered monocyclic saturated or partially unsaturated carbocyclic ring, a 4-8 membered monocyclic saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, phenyl, an 8-10 membered bicyclic aryl ring, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein R 4  is substituted by q instances of R 7 ; each R 5  is independently hydrogen, C 1-4  aliphatic, a 3-8 membered monocyclic saturated or partially unsaturated carbocyclic ring, a 4-8 membered monocyclic saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, phenyl, an 8-10 membered bicyclic aryl ring, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein each R 5  is substituted with r instances of R 8 ; each R 9  is independently oxo or \u2014OR 5 ; m is 0, 1, 2, or 3; n is 0, 1, or 2; p is 0, 1, 2, 3, or 4; q is 0, 1, 2, 3, 4, or 5; and r is 0, 1, 2, 3, or 4.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 96.0
- Lexical Diversity: 1.08
- Patent Class: 504.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15334955', '13673610', '15917190', '14890344', '14890308']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7518420646747793
- 35 USC 102 Novelty (BERT): 0.5247306989353198
- Combined Prediction Score: 0.7291309281008334
- Mean Citation Score: 282.458722
- Max Citation Score: 297.06076
- Similarity Product: 273.1937924961281

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test