PATENT CLAIM ANALYSIS

Application Number: 16394308
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["514", "253000"]

Abstract:
Compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 14 , W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.

Claim (Index 4):
The method according to  claim 1 , wherein the compound of formula (I) is compound of formula (I-a): wherein\n the ring system \n is selected from the group consisting of: R 1  represents a halogen atom, a linear or branched (C 1 -C 6 )alkyl group, a linear or branched (C 2 -C 6 )alkenyl group, a linear or branched (C 2 -C 6 )alkynyl group, a linear or branched (C 1 -C 6 )polyhaloalkyl group, a hydroxy group, a hydroxy(C 1 -C 6 )alkyl group, a linear or branched (C 1 -C 6 )alkoxy group, \u2014S\u2014(C 1 -C 6 )alkyl, a cyano group, a nitro group, -alkyl(C 0 -C 6 )\u2014NR 11 R 11 \u2032, \u2014O-alkyl(C 1 -C 6 )\u2014NR 11 R 11 \u2032, \u2014O-alkyl(C 1 -C 6 )\u2014R 12 , \u2014C(O)\u2014OR 1 , \u2014O\u2014C(O)\u2014R 11 , \u2014C(O)\u2014NR 11 R 11 \u2032, \u2014NR 11 \u2014C(O)\u2014R 11 \u2032, \u2014NR 11 \u2014C(O)\u2014OR 11 \u2032, -alkyl(C 1 -C 6 )\u2014NR 11 \u2014C(O)\u2014R 11 \u2032, \u2014SO 2 \u2014NR 11 R 11 \u2032, \u2014SO 2 -alkyl(C 1 -C 6 ), R 2 , R 3 , R 4  and R 5  independently of one another represent a hydrogen atom, a halogen atom, a linear or branched (C 1 -C 6 )alkyl group, a linear or branched (C 2 -C 6 )alkenyl group, a linear or branched (C 2 -C 6 )alkynyl group, a linear or branched (C 1 -C 6 )polyhaloalkyl, a hydroxy group, a hydroxy(C 1 -C 6 )alkyl group, a linear or branched (C 1 -C 6 )alkoxy group, a \u2014S\u2014(C 1 -C 6 )alkyl group, a cyano group, a nitro group, -alkyl(C 0 -C 6 )\u2014NR 11 R 11 \u2032, \u2014O-alkyl(C 1 -C 6 )\u2014NR 11 R 11 \u2032, \u2014O-alkyl(C 1 -C 6 )\u2014R 12 , \u2014C(O)\u2014OR 11 , \u2014O\u2014C(O)\u2014R 11 , \u2014C(O)\u2014NR 11 R 11 \u2032, \u2014NR 11 \u2014C(O)\u2014R 11 \u2032, \u2014NR 11 \u2014C(O)\u2014OR 11 \u2032, -alkyl(C 1 -C 6 )\u2014NR 11 \u2014C(O)\u2014R 11 \u2032, \u2014SO 2 \u2014NR 11 R 11 \u2032, or \u2014SO 2 -alkyl(C 1 -C 6 ), or the substituents of the pair (R 1 , R 2 ), together with the carbon atoms carrying them, form an aromatic or non-aromatic ring having from 5 to 7 ring members, which ring may contain from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen, wherein the resulting ring may be substituted by from 1 to 2 groups selected from halogen, linear or branched (C 1 -C 6 )alkyl, -alkyl(C 0 -C 6 )\u2014NR 11 R 11 \u2032, \u2014NR 13 R 13 \u2032, -alkyl(C 0 -C 6 )-Cy 1  and oxo, R 6  and R 7  independently of one another represent a hydrogen atom, a halogen atom, a linear or branched (C 1 -C 6 )alkyl group, a linear or branched (C 2 -C 6 )alkenyl group, a linear or branched (C 2 -C 6 )alkynyl group, a linear or branched (C 1 -C 6 )polyhaloalkyl, a hydroxy group, a linear or branched (C 1 -C 6 )alkoxy group, a \u2014S\u2014(C 1 -C 6 )alkyl group, a cyano group, a nitro group, -alkyl(C 0 -C 6 )\u2014NR 11 R 11 \u2032, \u2014O\u2014Cy 1 , -alkyl(C 0 -C 6 )-Cy 1 , -alkenyl(C 2 -C 6 )-Cy 1 , -alkynyl(C 2 -C 6 )-Cy 1 , \u2014O-alkyl(C 1 -C 6 )\u2014R 12 , \u2014C(O)\u2014OR 11 , \u2014O\u2014C(O)\u2014R 11 , \u2014C(O)\u2014NR 11 R 11 \u2032, \u2014NR 11 \u2014C(O)\u2014R 11 \u2032, \u2014NR 11 \u2014C(O)\u2014OR 11 \u2032, -alkyl(C 1 -C 6 )\u2014NR 11 \u2014C(O)\u2014R 11 \u2032, \u2014SO 2 \u2014NR 11 R 11 \u2032, \u2014SO 2 -alkyl(C 1 -C 6 ), or the substituents of the pair (R 6 , R 7 ), when grafted onto two adjacent carbon atoms, together with the carbon atoms carrying them, form an aromatic or non-aromatic ring composed of from 5 to 7 ring members, which ring may contain from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen, wherein the resulting ring may be substituted by a group selected from a linear or branched (C 1 -C 6 )alkyl group, \u2014NR 13 R 13 \u2032, -alkyl(C 0 -C 6 )-Cy 1  and oxo, W represents a \u2014CH 2 \u2014 group, a \u2014NH\u2014 group or an oxygen atom, R 8  represents a hydrogen atom, a linear or branched (C 1 -C 8 )alkyl group, a \u2014CHR a R b  group, an aryl group, a heteroaryl group, an arylalkyl(C 1 -C 6 ) group, or a heteroarylalkyl(C 1 -C 6 ) group, R 9  represents a hydrogen atom, a linear or branched (C 1 -C 6 )alkyl group, a linear or branched (C 2 -C 6 )alkenyl group, a linear or branched (C 2 -C 6 )alkynyl group, -Cy 2 , -alkyl(C 1 -C 6 )-Cy 2 , -alkenyl(C 2 -C 6 )-Cy 2 , -alkynyl(C 2 -C 6 )-Cy 2 , -Cy 2 -Cy 3 , -alkynyl(C 2 -C 6 )\u2014O\u2014Cy 2 , -Cy 2 -alkyl(C 0 -C 6 )\u2014O-alkyl(C 0 -C 6 )-Cy 3 , a halogen atom, a cyano group, \u2014C(O)\u2014R 15 , or \u2014C(O)\u2014NR 15 R 15 \u2032, R 11  and R 11 \u2032 independently of one another represent a hydrogen atom, a linear or branched (C 1 -C 6 )alkyl group, or the substituents of the pair (R 11 , R 11 \u2032), together with the nitrogen atom carrying them, form an aromatic or non-aromatic ring having from 5 to 7 ring members, which ring may contain, in addition to the nitrogen atom, from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen, wherein the nitrogen may be substituted by a hydrogen atom or a linear or branched (C 1 -C 6 )alkyl group, R 12  represents -Cy 5 , -Cy 5 -alkyl(C 0 -C 6 )\u2014O-alkyl(C 0 -C 6 )-Cy 6 , -Cy 5 -alkyl(C 0 -C 6 )-Cy 6 , -Cy 5 -alkyl(C 0 -C 6 )\u2014NR 11 -alkyl(C 0 -C 6 )-Cy 6 , -Cy 5 -Cy 6 -O-alkyl(C 0 -C 6 )-Cy 7 , \u2014C(O)\u2014NR 11 R 11 \u2032, \u2014NR 11 R 11 \u2032, \u2014OR 11 , \u2014NR 11 \u2014C(O)\u2014R 11 \u2032, \u2014O-alkyl(C 1 -C 6 )\u2014OR 1 , \u2014SO 2 \u2014R 11 , \u2014C(O)\u2014OR 11 , or \u2014NH\u2014C(O)\u2014NH\u2014R 11 , R 13 , R 13 \u2032, R 15  and R 15 \u2032, independently of one another, represent a hydrogen atom, or an optionally substituted linear or branched (C 1 -C 6 )alkyl group, R 14  represents a hydrogen atom, a hydroxy group, or a hydroxy(C 1 -C 6 )alkyl group, R a  represents a hydrogen atom or a linear or branched (C 1 -C 6 )alkyl group, R b  represents a \u2014O\u2014C(O)\u2014O\u2014R c  group, a \u2014O\u2014C(O)\u2014NR c R c \u2032 group, or a \u2014O\u2014P(O)(OR c ) 2  group, R c  and R c \u2032, independently of one another, represent a hydrogen atom, a linear or branched (C 1 -C 8 )alkyl group, a cycloalkyl group, a (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl group, or the substituents of the pair (R c , R c \u2032), together with the nitrogen atom carrying them, form a non-aromatic ring having from 5 to 7 ring members, which ring may contain, in addition to the nitrogen atom, from 1 to 3 heteroatoms selected from oxygen and nitrogen, wherein the nitrogen in question may be substituted by a linear or branched (C 1 -C 6 )alkyl group, Cy 1 , Cy 2 , Cy 3 , Cy 4 , Cy 5 , Cy 6  and Cy 7 , independently of one another, represent a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group, n is an integer equal to 0 or 1, wherein:\n \u201caryl\u201d means a phenyl, naphthyl, biphenyl, indanyl or indenyl group, \n \u201cheteroaryl\u201d means any mono- or bi-cyclic group composed of from 5 to 10 ring members, having at least one aromatic moiety and containing from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen, \n \u201ccycloalkyl\u201d means any mono- or bi-cyclic non-aromatic carbocyclic group containing from 3 to 10 ring members, \n \u201cheterocycloalkyl\u201d means any mono- or bi-cyclic non-aromatic carbocyclic group containing from 3 to 10 ring members, and containing from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen, which may include fused, bridged or spiro ring systems, \n wherein the aryl, heteroaryl, cycloalkyl and heterocycloalkyl groups so defined and the alkyl, alkenyl, alkynyl, alkoxy groups, may be substituted by from 1 to 4 groups selected from optionally substituted linear or branched (C 1 -C 6 )alkyl, optionally substituted linear or branched (C 2 -C 6 )alkenyl, optionally substituted linear or branched (C 2 -C 6 )alkynyl, optionally substituted linear or branched (C 1 -C 6 )alkoxy, optionally substituted (C 1 -C 6 )alkyl-S\u2014, hydroxy, oxo (or N-oxide where appropriate), nitro, cyano, \u2014C(O)\u2014OR\u2032, \u2014O\u2014C(O)\u2014R\u2032, \u2014C(O)\u2014NR\u2032R\u2033, \u2014O\u2014C(O)\u2014NR\u2032R\u2033, \u2014NR\u2032R\u2033, \u2014(C\u2550NR\u2032)\u2014OR\u2033, \u2014O\u2014P(O)(OR\u2032) 2 , \u2014O\u2014P(O)(O \u2212 M + ) 2 , linear or branched (C 1 -C 6 )polyhaloalkyl, trifluoromethoxy, halogen, or an aldohexose of formula: in which each R\u2032 is independent; wherein R\u2032 and R\u2033, independently of one another, represent a hydrogen atom or an optionally substituted linear or branched (C 1 -C 6 )alkyl group, and M +  represents a pharmaceutically acceptable monovalent cation, its enantiomers, diastereoisomers and atropisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.

Metadata:
- Claim Count in Document: 95.0
- Percentile: 100.0
- Lexical Diversity: 1.5
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15738186', '15737479', '15737783', '15738601', '15492306']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8213961890927645
- 35 USC 102 Novelty (BERT): 0.5751873194175037
- Combined Prediction Score: 0.7967753021252384
- Mean Citation Score: 423.82738200000006
- Max Citation Score: 447.99300000000005
- Similarity Product: 436.6454943546654

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test