PATENT CLAIM ANALYSIS

Application Number: 16135729
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["546", "273400"]

Abstract:
Described are N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)benzamide and acetamide-containing compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

Claim (Index 1):
A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein: R 1  is hydrogen or C 1-4 alkyl; R 2  is hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, or C 3-8 cycloalkyl-C 1-3 alkylene-; X 1  is a bond or \u2014N(R a )\u2014, wherein R a  is hydrogen, C 1-4 alkyl, or C 1-4 haloalkyl; R 3  is C 1-4 alkyl, G 1 , or -L-G 2 ; G 1  and G 2  are C 3-8 cycloalkyl, 4- to 8-membered heterocyclyl, aryl, or heteroaryl, wherein G 1  and G 2  are optionally substituted with 1-5 substituents independently selected from the group consisting of halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, \u2014O\u2014C 1-4 alkyl, \u2014O\u2014C 1-4 haloalkyl, OH, oxo, \u2014C(O)C 1-4 alkyl, \u2014C(O)C 1-4 haloalkyl, \u2014NH 2 , \u2014NH(C 1-4 alkyl), \u2014N(C 1-4 alkyl) 2 , \u2014NHC(O)C 1-4 alkyl, and \u2014N(C 1-4 alkyl)C(O)C 1-4 alkyl; L 1  is \u2014C 1-3 alkylene-; R 4a , at each occurrence, is independently hydrogen, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, \u2014O\u2014C 1-4 alkyl, or OH; R 4b , at each occurrence, is independently hydrogen, halogen, or C 1-4 alkyl; or R 4a  and R 4b  together with the carbon to which they are attached form a C 3-6 cycloalkyl; n is 1 or 2; X 2  is C(R 4a )(R 4b ), O, S, or N(R 5 ); R 5  is hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-3 alkylene-, \u2014C(O)C 1-4 alkyl, \u2014C(O)C 3-6 cycloalkyl, or \u2014C(O)OC 1-4 alkyl; R 6a , R 6b , R 7a , R 7b , R 8a , and R 8b  are each independently selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, halo, and hydroxy; and R 9 , R 10 , and R 11  are each independently selected from the group consisting of hydrogen, halogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, \u2014O\u2014C 1-4 alkyl, and \u2014O\u2014C 1-4 haloalkyl.

Metadata:
- Claim Count in Document: 16.0
- Percentile: 97.0
- Lexical Diversity: 1.28947
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15703289', '14206028', '13828285', '14392200', '13548785']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8021781507388877
- 35 USC 102 Novelty (BERT): 0.5575160203576034
- Combined Prediction Score: 0.7777119377007593
- Mean Citation Score: 349.4888620000001
- Max Citation Score: 432.6185
- Similarity Product: 347.47985244339696

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test