PATENT CLAIM ANALYSIS

Application Number: 15756342
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-10
Patent Classification: ["514", "295000"]

Abstract:
Provided are a conjugate of memantine and arctigenin, and a pharmaceutical composition comprising the conjugate. The conjugate can treat diseases associated with Aβ or Tau protein pathways, such as Alzheimer's disease or Parkinson's disease.

Claim (Index 2):
The conjugate according to  claim 1 , which is a compound of general formula (I), or a pharmaceutically acceptable salt, stereoisomer, polymorph, solvate or prodrug thereof: wherein: Linker 1 is selected from the group consisting of \u2014C(O)\u2014, \u2014C(O)L 1 C(O)\u2014, \u2014C(O)OL 1 C(O)\u2014, \u2014C(O)OL 1 OC(O)\u2014, \u2014C(O)OQ 1 L 2 Q 2 -, \u2014C(O)Q 1 L 2 Q 2 N(R 1 )C(O)\u2014, \u2014C(O)Q 1 L 2 Q 2 OC(O)\u2014, \u2014C(O)Q 1 L 2 Q 2 C(O)\u2014, \u2014C(O)OQ 1 L 2 Q 2 OC(O)\u2014, \u2014C(O)OQ 1 L 1 Q 2 N(R 1 )C(O)\u2014, \u2014C(O)OQ 1 L 2 Q 2 N(R 1 )C(O)\u2014 and \u2014C(O)OQ 1 L 2 Q 2 C(O)\u2014; L 1  is a direct bond, or is selected from the group consisting of \u2014O\u2014, \u2014S\u2014, \u2014NR 2 \u2014, substituted or unsubstituted C1-C6 straight or branched alkylene, substituted or unsubstituted C2-C6 straight or branched alkenylene, substituted or unsubstituted C2-C6 straight or branched alkynylene, substituted or unsubstituted C3-C10 cycloalkylene, substituted or unsubstituted C3-C10 non-aromatic heterocyclylene, substituted or unsubstituted C6-C14 arylene, substituted or unsubstituted C6-C14 heteroarylene, and substituted or unsubstituted C6-C20 aralkylene; L 2  is a direct bond, or is selected from the group consisting of \u2014NR 2 \u2014, \u2014O\u2014, \u2014C(O)\u2014, \u2014N(R 3 )C(O)\u2014, \u2014C(O)N(R 3 )\u2014, \u2014C(O)O\u2014, \u2014OC(O)\u2014, \u2014N(R 3 )Q 3 O\u2014, \u2014N(R 3 )C(O)Q 3 O\u2014, \u2014N(R 3 )C(O)Q 3 C(O)\u2014, \u2014N(R 3 )C(O)Q 3 N(R 3 )\u2014, \u2014N(R 3 )C(O)Q 3 C(O)N(R 3 )\u2014, \u2014N(R 3 )C(O)Q 3 N(R 3 )C(O)\u2014, \u2014N(R 3 )C(O)Q 3 C(O)O\u2014, \u2014N(R 3 )C(O)Q 3 OC(O)\u2014, \u2014C(O)N(R 3 )Q 3 C(O)N(R 3 )\u2014, \u2014C(O)N(R 3 )Q 3 C(O)O\u2014, \u2014C(O)N(R 3 )Q 3 N(R 3 )C(O)\u2014, \u2014C(O)N(R 3 )Q 3 OC(O)\u2014, \u2014N(R 3 )Q 3 C(O)N(R 3 )\u2014, \u2014N(R 3 )Q 3 C(O)O\u2014, \u2014N(R 3 )Q 3 N(R 3 )C(O)\u2014, \u2014N(R 3 )Q 3 OC(O)\u2014, -OQ 3 N(R 3 )\u2014, -OQ 3 C(O)N(R 3 )\u2014, -OQ 3 C(O)O\u2014, -OQ 3 N(R 3 )C(O)\u2014, -OQ 3 OC(O)\u2014, \u2014OC(O)Q 3 -, \u2014OC(O)Q 3 C(O)N(R 3 )\u2014, \u2014OC(O)Q 3 C(O)O\u2014, \u2014OC(O)Q 3 N(R 3 )\u2014, \u2014OC(O)Q 3 N(R 3 )C(O)\u2014, \u2014OC(O)Q 3 N(R 3 )L 1 O\u2014, \u2014OC(O)Q 3 OC(O)\u2014, \u2014C(O)OQ 3 -, \u2014C(O)OQ 3 O\u2014, \u2014C(O)OQ 3 C(O)N(R 3 )\u2014, \u2014C(O)OQ 3 C(O)O\u2014, \u2014C(O)OQ 3 N(R 3 )C(O)\u2014 or \u2014C(O)OQ 3 OC(O)\u2014; Q 1 , Q 2  and Q 3  are each independently selected from the group consisting of substituted or unsubstituted C1-C6 straight or branched alkylene, substituted or unsubstituted C3-C10 cycloalkylene, substituted or unsubstituted C2-C6 straight or branched alkenylene, substituted or unsubstituted C2-C6 straight or branched alkynylene, substituted or unsubstituted C3-C10 non-aromatic heterocyclylene, substituted or unsubstituted C6-C14 arylene, substituted or unsubstituted C6-C14 heteroarylene, and substituted or unsubstituted C6-C20 aralkylene; and R 1 , R 2  and R 3  are each independently selected from the group consisting of H and C1-C6 alkyl.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 88.0
- Lexical Diversity: 1.29032
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13063525', '16084979', '13940016', '15552556', '13442244']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7834406071274514
- 35 USC 102 Novelty (BERT): 0.502888406383006
- Combined Prediction Score: 0.755385387053007
- Mean Citation Score: 207.164244
- Max Citation Score: 211.74594
- Similarity Product: 129.2203444541037

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test