PATENT CLAIM ANALYSIS

Application Number: 16198902
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["435", "006120"]

Abstract:
The present invention provides methods, compositions and kits for enriching and determining nucleotide sequences of a plurality of target loci from a sample comprising nucleic acids. The methods comprise one or more cycles of primer extension followed by PCR amplification of target sequences using nested target-specific primers.

Claim (Index 14):
A method of detecting a sequence variant at a locus of interest in a nucleic acid sample comprising a nucleic acid template comprising a target nucleotide sequence having the locus of interest, the method comprising:\n (1) determining the target sequence having the locus of interest using the method of  claim 8 ; and (2) detecting the sequence variant in the target nucleotide sequence, optionally, wherein: (a) the sequence variant is present at an allele frequency of no more than about 1:100; (b) the sequence variant is inherited in germline DNA; (c) the sequence variant is a somatic mutation or chromosomal rearrangement; (d) a plurality of sequence variants are detected, for example, wherein the plurality of sequence variants are selected from the group consisting of chromosomal rearrangements, splice variants, SNP, deletions, insertions, copy number variants (CNV), and combinations thereof; and/or (e) the method simultaneously detects a chromosomal rearrangement based on cDNA sequences, and a mutation based on gDNA sequences.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 98.0
- Lexical Diversity: 1.25
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14463498', '13793564', '15269448', '12069174', '14300048']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.5629846000727453
- 35 USC 102 Novelty (BERT): 0.5333006315275518
- Combined Prediction Score: 0.5600162032182259
- Mean Citation Score: 339.0472660000001
- Max Citation Score: 356.35602
- Similarity Product: 231.70103077753544

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test