PATENT CLAIM ANALYSIS

Application Number: 16116065
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["514", "217000"]

Abstract:
Described herein are IRE1α inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.

Claim (Index 1):
A compound of formula I, wherein: A and B are each independently a heterocyclyl ring, where the A ring has x R 1  substituents; C is phenyl or pyridinyl; D is heterocyclyl ring; linkage 1  is a single bond between A and B; linkage 2  is a urea, alkylurea, or ureaalkyl with a first and second terminal atom; y is an integer of 0-3, and when y is 0, the linkage between the rings is a single bond; x is an integer of 0-4; v is an integer of 0-2; R 1  substituents on the A ring are selected from amino, optionally substituted C 1 -C 4  alkyl, optionally substituted ether, optionally substituted C 1 -C 4  alkoxy, hydroxy, \u2014NH\u2014SO 2 -phenyl-(R 5 ), and cyano; R 2  substituents on the B ring are selected from amino, and optionally substituted C 1 -C 4  alkyl; R 3  substituents on the C ring are selected from halo, CF 3 , optionally substituted C 1 -C 4  alkyl, and optionally substituted heteroaryl; and R 4  substituents on the D ring are selected from optionally substituted C 1 -C 4  alkyl, optionally substituted C 1 -C 4  alkoxy, (optionally substituted C 1 -C 4  alkylene)-OH, hydroxy, optionally substituted aryl, optionally substituted benzyl, and optionally substituted benzaldehyde; and R 5  is halo; or a pharmaceutically acceptable salt thereof.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 96.0
- Lexical Diversity: 1.30435
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15449547', '13697743', '15506380', '14428546', '12892351']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7735240125828445
- 35 USC 102 Novelty (BERT): 0.5149909310806096
- Combined Prediction Score: 0.7476707044326211
- Mean Citation Score: 233.41375
- Max Citation Score: 289.48477
- Similarity Product: 203.93006866116048

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test