PATENT CLAIM ANALYSIS

Application Number: 16175220
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-02
Patent Classification: ["424", "094300"]

Abstract:
Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules or activated glucocerebrosidase conjugated to the small molecules, which compositions may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease.

Claim (Index 1):
A compound or a salt or solvate thereof having a Formula I: wherein: R 1  is hydrogen or C1-C10 alkyl; n is 0, 1, 2, 3, or 4; and R 2  is hydrogen with the proviso that not both of R 1  and R 2  are hydrogen, a C1-C10 alkyl group (straight chain or branched), a C3-C8 cycloalkyl group, a saturated or unsaturated homocycle or heterocycle group comprising one 5- or 6-membered ring or comprising two or three fused 5- or 6-membered rings, a phenoxy group, a C1-C6-branched or straight chain alkyl-phenoxy group, a 2,3-dihydro-1H-indenyl group, a 1,2,3,4-tetrahydro-naphthalenyl group, a C2-C10 straight chain or branched alkenyl group, a C2-C10 straight chain or branched alkynyl group, a polyethylene oxide group, a pyridinoxy group, an indoloxy group, a benzofuranoxy group, or R 2  has a formula selected from wherein R 8  is hydrogen, C1-C8 alkyoxy, C1-C8 alkyl, halo, or R 8  has a formula selected from p is 1-10 and R 9  is amino or R 9  has a formula selected from wherein R 10  is H, C1-C6 straight chain or branched alkyl, or a succinimidyl group;\n R 2  optionally is substituted at one or more positions with a C1-C8 alkyl group, a C1-C8 alkoxy group, a halo group, a phenyl group, a benzyl group, an amino group, a hydroxyl group, a tert-butyloxycarbonyl (BOC) group, a sulfonylmethylphenyl group, a 2,3-dihydro-1,4-benzodioxine-2-carbaldehyde group, a 2,3-dihydromethyl-1,4-benzodioxin group, an imidazole group, a piperazinyl group, a 1-methylpiperazinyl group, a 4-piperazin-1-yl-benzaldehyde group, a 4-(4-methylpiperazin-1-yl)benzaldehyde group, or an azide group; or \n where n is 0, R 1  and R 2  together form a heterocycle comprising one, two, or three 5- or 6-membered rings; and \n R 3  is pyridinyl, phenyl, thiophenyl, halo, furanyl, pyrimidinyl, and R 3  optionally is substituted at one or more positions with C1-C8 alkyl, halo, amino, amido, or R 3  has a formula, \n wherein R 4  is amino, or R 4  has a formula wherein R 5  is \u2014CH 2 \u2014 or \u2014O\u2014CH 2 \u2014CH 2 \u2014, and m is 0-4, R 6  is H or R 6  has a formula wherein R 7  is H, \u2014OH, C1-C8 alkyl, or C1-C8 alkoxy.

Metadata:
- Claim Count in Document: 59.0
- Percentile: 97.0
- Lexical Diversity: 1.4
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15199207', '16021972', '15199220', '15789645', '10988428']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7145054078611388
- 35 USC 102 Novelty (BERT): 0.5605419345230215
- Combined Prediction Score: 0.699109060527327
- Mean Citation Score: 340.0264140000001
- Max Citation Score: 457.09766
- Similarity Product: 303.8350902471745

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test