PATENT CLAIM ANALYSIS

Application Number: 16189894
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-02
Patent Classification: ["530", "324000"]

Abstract:
The present invention relates to a chromatography ligand, which comprises Domain C from  Staphylococcus  protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.

Claim (Index 28):
The process of  claim 27 , further comprising (c) eluting the compound(s) by passing a second liquid through the chromatography matrix that releases the compound(s) from the ligand.

Metadata:
- Claim Count in Document: 71.0
- Percentile: 98.0
- Lexical Diversity: 1.57333
- Patent Class: 530.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15603285', '15063471', '13559663', '14164519', '12443011']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7118116644021041
- 35 USC 102 Novelty (BERT): 0.5342899071952031
- Combined Prediction Score: 0.694059488681414
- Mean Citation Score: 357.172208
- Max Citation Score: 377.6914
- Similarity Product: 287.4931822705745

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test