PATENT CLAIM ANALYSIS

Application Number: 15763698
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2019-01
Patent Classification: ["548", "513000"]

Abstract:
The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Claim (Index 1):
A compound of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein: R 1  is independently selected from hydroxy, halogen, nitro, nitrile, C 1-4 alkyl, haloC 1-4 alkyl, hydroxyC 1-4 alkyl, C 2-6 alkenyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 2-4 alkynyl, \u2014O 0,1 \u2014(CR x R y ) v \u2014CO 2 H, \u2014(CR x R y ) v \u2014CO 2 C 1-4 alkyl, \u2014(CR x R y ) v \u2014CON(C 1-4 alkyl) 2 , \u2014P(\u2550O)(R x ) 2 , \u2014S(O) d \u2014R x , \u2014S(O) d -heterocyclic group with 3 to 6 ring members and \u2014S(O) d \u2014N(R 8 ) 2 ; R 2  is selected from hydrogen, C 1-4  alkyl, C 2-6 alkenyl, hydroxyC 1-4 alkyl, \u2014(CR x R y ) u \u2014CO 2 H, \u2014(CR x R y ) u \u2014CO 2 C 1-4 alkyl, and \u2014(CR x R y ) u \u2014CONR x R y ; s is selected from 0 and 1; R 3  is hydrogen or -(A) t -(CR x R y ) q \u2014X; t is selected from 0 and 1; q is selected from 0, 1 and 2; wherein when R 3  is -(A) t -(CR x R y ) q \u2014X then (i) at least one of s, t and q is other than 0 and (ii) when t is 0 then s is 1 and q is other than 0; A is a C 3-6 cycloalkyl group or a heterocyclic group with 3 to 6 ring members, wherein the heterocyclic group comprises one or more heteroatoms selected from N, O, S and oxidised forms thereof; X is selected from hydrogen, halogen, \u2014CN, \u2014OR 9 , \u2014(CH 2 ) v \u2014CO 2 H, \u2014(CH 2 ) v \u2014CO 2 C 1-4 alkyl, \u2014S(O) d \u2014R x , \u2014C(\u2550O)\u2014C 1-4 alkyl, \u2014S(O) d \u2014N(H) e (C 1-4 alkyl) 2-e , \u2014NR x R y , \u2014NHSO 2 R x , \u2014NR x COR y , and \u2014C(\u2550O)NR x R y ; R 4  and R 5  are independently selected from halogen, nitrile, C 1-4  alkyl, haloC 1-4 alkyl, C 1-4 alkoxy and haloC 1-4 alkoxy; R 6  and R 7  are independently selected from hydrogen, C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, hydroxy, hydroxyC 1-6 alkyl, \u2014COOC 1-6 alkyl, \u2014(CH 2 ) j \u2014O\u2014C 1-6 alkyl, \u2014(CH 2 ) j \u2014O-(hydroxyC 1-6 alkyl), \u2014C 1-6 alkyl-NR x R y , \u2014(CR x R y ) p \u2014CONR x R y , \u2014(CR x R y ) p \u2014NR x COR y , \u2014(CR x R y ) p \u2014O\u2014CH 2 \u2014CONR x R y , heterocyclic group with 3 to 7 ring members, \u2014CH 2 -heterocyclic group with 3 to 7 ring members, \u2014CH 2 \u2014O-heterocyclic group with 3 to 7 ring members, \u2014CH 2 \u2014NH-heterocyclic group with 3 to 7 ring members, \u2014CH 2 \u2014N(C 1-6 alkyl)-heterocyclic group with 3 to 7 ring members, \u2014C(\u2550O)NH-heterocyclic group with 3 to 7 ring members, C 3-8 cycloalkyl, \u2014CH 2 \u2014C 3-8 cycloalkyl, \u2014CH 2 \u2014O\u2014C 3-8 cycloalkyl, and C 3-8 cycloalkenyl, wherein said cycloalkyl, cycloalkenyl or heterocyclic groups may be optionally substituted by one or more R z  groups, and wherein in each instance the heterocyclic group comprises one or more heteroatoms selected from N, O, S and oxidised forms thereof; or the R 6  and R 7  groups, together with the carbon atom to which they are attached, can join to form a C 3-6 cycloalkyl or heterocyclyl group with 3 to 6 ring members, wherein the heterocyclic group comprises one or more heteroatoms selected from N, O, S and oxidised forms thereof, and wherein said C 3-6 cycloalkyl and heterocyclyl groups may be optionally substituted by one or more R z  groups; R 8  and R 9  are independently selected from hydrogen, C 1-6 alkyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, \u2014(CH 2 ) k \u2014O\u2014C 1-6 alkyl, \u2014(CH 2 ) k \u2014O-(hydroxyC 1-6 alkyl), hydroxyC 1-6 alkoxy, \u2014(CH 2 ) k \u2014CO 2 C 1-6 alkyl, \u2014(CH 2 ) k \u2014CO 2 H, \u2014C 1-6  alkyl-N(H) e (C 1-4 alkyl) 2-e , \u2014(CH 2 ) j \u2014C 3-8 cycloalkyl and \u2014(CH 2 ) j \u2014C 3-8 cycloalkenyl; R x  and R y  are independently selected from hydrogen, halogen, nitro, nitrile, C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, hydroxy, hydroxyC 1-6 alkyl, C 1-6 alkoxy, \u2014(CH 2 ) k \u2014O\u2014C 1-6 alkyl, hydroxyC 1-6 alkoxy, \u2014COOC 1-6 alkyl, \u2014N(H) e (C 1-4 alkyl) 2-e , \u2014C 1-6 alkyl-N(H) e (C 1-4 alkyl) 2-e , \u2014(CH 2 ) k \u2014C(\u2550O)N(H) e (C 1-4 alkyl) 2-e , C 3-8 cycloalkyl and C 3-8 cycloalkenyl; or the R x  and R y  groups, together with the carbon or nitrogen atom to which they are attached, can join to form a C 3-6 cycloalkyl or saturated heterocyclyl group with 3 to 6 ring members which may be optionally fused to an aromatic heterocyclyl group of 3 to 5 ring members; or when on a carbon atom the R x  and R y  groups can join together to form a \u2550CH 2  group; R z  is independently selected from halogen, nitro, nitrile, C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, \u2550O, hydroxy, hydroxyC 1-6 alkyl, C 1-6 alkoxy, \u2014(CH 2 ) k \u2014O\u2014C 1-6 alkyl, hydroxyC 1-6 alkoxy, \u2014C(\u2550O)C 1-6 alkyl, \u2014C(\u2550O)C 1-6 alkyl-OH, \u2014C(\u2550O)C 1-6 alkyl-N(H) e (C 1-4 alkyl) 2-e , \u2014C(\u2550O)N(H) e (C 1-4 alkyl) 2-e , \u2014(CH 2 ) r \u2014CO 2 C 1-6 alkyl, \u2014(CH 2 ) r \u2014CO 2 H, \u2014N(H) e (C 1-4 alkyl) 2-e , \u2014C 1-6 alkyl-N(H) e (C 1-4 alkyl) 2-e , heterocyclyl group with 3 to 6 ring members, heterocyclyl group with 3 to 6 ring members substituted by \u2014C(\u2550O)C 1-4 alkyl, heterocyclyl group with 3 to 6 ring members substituted by \u2014C(\u2550O)OC 1-4 alkyl, heterocyclyl group with 3 to 6 ring members substituted by \u2014C(\u2550O)N(H) e (C 1-4 alkyl) 2-e , \u2014C(\u2550O)heterocyclyl group with 3 to 6 ring members, C 3-8 cycloalkyl and C 3-8 cycloalkenyl, wherein if R 7  is pyridine then R z  is other then \u2014NH 2 ; a, j, d, e, n, r and p are independently selected from 0, 1 and 2; k and m are independently selected from 1 and 2; u is selected from 0, 1, 2 and 3; and v and w are independently selected from 0 and 1.

Metadata:
- Claim Count in Document: 11.0
- Percentile: 90.0
- Lexical Diversity: 1.4878
- Patent Class: 548.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15763724', '15767775', '14788675', '14982127', '13748790']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7682439800463502
- 35 USC 102 Novelty (BERT): 0.5928368941006992
- Combined Prediction Score: 0.7507032714517851
- Mean Citation Score: 361.395318
- Max Citation Score: 495.61688
- Similarity Product: 461.1537087009765

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test