PATENT CLAIM ANALYSIS

Application Number: 15907470
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-09
Patent Classification: ["435", "440000"]

Abstract:
The present invention relates to an improved method for cell line development which is generally applicable to production of any therapeutic protein that can be produced using mammalian Cell lines and in particular Chinese Hamster Ovary (CHO) cells. The method combines site directed integration (SDI), expression construct components improving the post-transcriptional processing of the gene of interest (GOI), novel design of the GOI genome target location and the introduction of a onetime pre-CLD host cell line selection workflow to generate a production competent cell line that can then be used in multiple CLD efforts from that point on.

Claim (Index 5):
Method according to  claim 1 , wherein said production traits contain at least one trait selected from the following list; cell growth, cell viability, cell specific productivity for the template protein of interest, template protein of interest aggregate level, level of template protein of interest charge variants, level of truncated protein of interest variants, glycosylation profile for the template protein of interest, glycosylation site occupancy for the template protein of interest, level of tertiary structure heterogeneity for the template protein of interest, level of host cell proteins secreted into the culture medium, level of lactate production, level of ammonium production, level of glucose consumption rate, performance in a pre-defined platform cell culture media, performance in a pre-defined platform bioprocess, fit with a defined host cell proteomic profile, fit with a defined host cell mRNA profile, fit with a defined host cell miRNA profile, fit with a defined host cell line metabolome profile, cellular genome stability.

Metadata:
- Claim Count in Document: 24.0
- Percentile: 88.0
- Lexical Diversity: 1.38462
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14967689', '14092786', '13752647', '12793898', '12507252']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6129361900864408
- 35 USC 102 Novelty (BERT): 0.529459633661426
- Combined Prediction Score: 0.6045885344439395
- Mean Citation Score: 308.898376
- Max Citation Score: 313.97794
- Similarity Product: 180.8442302718198

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test