PATENT CLAIM ANALYSIS

Application Number: 16007829
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-10
Patent Classification: ["435", "006120"]

Abstract:
The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.

Claim (Index 24):
A method for nucleic acid sequencing, comprising:\n (a) providing an array comprising a plurality of features in optical communication with a plurality of optical sensors, wherein said array is integrated with said plurality of optical sensors, wherein said plurality of features retains or immobilizes a plurality of nucleic acid molecules, wherein a feature of said plurality of features comprises a nucleic acid molecule of said plurality of nucleic acid molecules, and wherein an optical sensor of said plurality of optical sensors is in optical communication with said feature; (b) contacting said nucleic acid molecule with nucleic acid bases in the presence of a polymerizing enzyme under conditions sufficient to incorporate at least one of said nucleic acid bases into a growing strand complementary to said nucleic acid molecule; (c) using said optical sensor to detect one or more signals indicative of said at least one of said nucleic acid bases incorporated into said growing strand; (d) using said one or more signals detected in (c) to identify said at least one of said nucleic acid bases; and (e) monitoring and correcting for phase error introduced during incorporation of said at least one of said nucleic acid bases into said growing strand, thereby generating a sequence of said nucleic acid molecule.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 94.0
- Lexical Diversity: 1.42
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16007969', '14119859', '13838816', '13481858', '13824129']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.622003464200602
- 35 USC 102 Novelty (BERT): 0.5961090139095104
- Combined Prediction Score: 0.6194140191714929
- Mean Citation Score: 358.6721080000001
- Max Citation Score: 453.87985
- Similarity Product: 373.09222468809486

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test