PATENT CLAIM ANALYSIS

Application Number: 15764830
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["348", "080000"]

Abstract:
This application discloses a tools and techniques for using a remote-focusing element (such as an electro-tunable lens) to provide enhanced focusing in an all-optical digital scanning microscopy system. The remote-focusing element can imaging of different sections of the specimen without moving the specimen itself, while at the same time providing the ability to correct for non-uniform indices of refraction in the imaged specimen and/or the surrounding medium which can cause misalignment between the imaged plane and the illuminated plane, which can result in loss focus in the imaged section of the specimen. The remote-focusing element can also obviate the need to move the detection stage and/or the illumination stage of the system to image different sections, eliminating vibration during the imaging process.

Claim (Index 15):
A microscope controller for a remote focusing all-optical digital scanning light sheet microscopy system, the microscope controller in communication with an electro-tunable lens, image detector, the microscope controller comprising:\n at least one processor; non-transitory computer readable media having encoded thereon computer software comprising a set of instructions executable by the at least one processor to:\n align, via the electro-tunable lens, a focal plane of a detection objective to an expected position of an illumination plane of a light sheet, the light sheet illuminating a first section of a specimen; \n capture, via the image detector, a first image of the first section detected by the detection objective; \n determine whether the first image of the first section is within a focus tolerance range, wherein the focus tolerance range specifies a threshold focus level for a captured image; \n identify at least one out-of-focus feature in the first image of the first section; \n adjust, via a driver of the electro-tunable lens, the focal length of the electro-tunable lens, wherein the focal plane of the detection objective is shifted to coincide with the position of the illumination plane of the light sheet at the at least one out-of-focus feature; and \n capture a second image of the first section having the at least one out-of-focus feature in focus.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 90.0
- Lexical Diversity: 1.68831
- Patent Class: 348.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13968220', '15266310', '15719299', '15695484', '15680075']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.594967222968162
- 35 USC 102 Novelty (BERT): 0.4677342564854034
- Combined Prediction Score: 0.5822439263198862
- Mean Citation Score: 189.394448
- Max Citation Score: 194.38135
- Similarity Product: 160.86423586130738

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test