PATENT CLAIM ANALYSIS

Application Number: 15769754
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2019-01
Patent Classification: ["514", "210160"]

Abstract:
The present invention relates to oxa-diazaspiro compounds having pharmacological activity towards the sigma (σ) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

Claim (Index 32):
A process for the preparation of the compound according to  claim 18 ,\n wherein R 1  is \u2014(CR 4 R 4\u2032 ) p R 1\u2032 , which process comprises:\n a) an intramolecular cyclization of a compound of formula VIIa \n wherein LG represents a leaving group, including halogen, mesylate, tosylate and triflate, with the proviso that when Y\u2550CO, LG represents chloro or bromo, or\n b) the reaction of a compound of formula VIIIH \n with a compound of formula IX, X or XI, wherein LG represents a leaving group, including halogen, mesylate, tosylate and triflate, or c1) when Y is CH 2 , by the alkylation of a compound of formula XIV with a compound of formula XV wherein the compound of formula XV is an alkylating agent and V is a leaving group, or alternatively by the reductive amination reaction of a compound of formula XIV with a compound of formula XV, wherein the compound of formula XV is an aldehyde and V is a C(O)H group; or c2) when Y is C(O), by the alkylation of a compound of formula XIV with a compound of formula XV wherein the compound of formula XV is an alkylating agent and V is a leaving group, and wherein R 1\u2032 , R 2 , R 3 , R 3\u2032 , R 4 , R 4\u2032 , R 5 , R 5\u2032 , R 6 , R 6\u2032 , R 7 , R 8 , R 9 , R 10 , R x , R x\u2032 , X, Y, m, n, p, q and r have the meanings as defined in  claim 18  for the compound of Formula (I).

Metadata:
- Claim Count in Document: 29.0
- Percentile: 91.0
- Lexical Diversity: 1.30556
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15769502', '15769520', '15315486', '15315095', '15569939']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8078969410348669
- 35 USC 102 Novelty (BERT): 0.5837390492574921
- Combined Prediction Score: 0.7854811518571294
- Mean Citation Score: 443.37464400000016
- Max Citation Score: 477.3474
- Similarity Product: 418.8622987627745

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test