PATENT CLAIM ANALYSIS

Application Number: 16040684
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-12
Patent Classification: ["514", "006200"]

Abstract:
The novel insulin derivates delivers, after administration to humans, insulin as a function of the glucose concentration in the tissue.

Claim (Index 1):
An insulin derivative of formula I: (Z 1 \u2014Y 1 \u2014X 1 ) m -Ins-(X\u2014Y\u2014Z) n  wherein n is zero or 1; m is zero or 1; with the proviso that not both n and m are zero;\n Ins represents insulin or an insulin analogue optionally having an A22 lysine, each Ins having an A chain and a B chain having a B29 lysine residue, from which a hydrogen atom has been removed from an \u03f5 amino group present in the B29 lysine residue, from an \u03f5 amino group present in the optional A22 lysine residue, or from the \u03f5 amino groups present in both the B29 and optional A22 lysine residues, and wherein the amino group present in the N terminal amino acid residue in the A chain, B chain, or both A and B chains, optionally, is substituted by one or two alkyl groups, and wherein \u2014X\u2014Y\u2014Z or \u2014X 1 \u2014Y 1 Z 1  is independently attached to the \u03f5 amino group in one or both of the B29 lysine or A22 lysine residues in the insulin or insulin analogue; X and X 1 , independently of each other, is a bond, a moiety of formula \u2014CO\u2014(C 1 -C 3 -alkylene)-CH(COOH)\u2014NH\u2014 wherein the amino group is connected to the Y/Y 1  moiety or a moiety of formula \u2014CO\u2014(C 1 -C 3 -alkylene)-SO 2 \u2014NH\u2014, wherein the amino group is connected to the Y/Y 1  moiety; Y and Y 1 , independently of each other, is \u03c9-amino alkanoyl group is a straight or branched alkyl group containing 6 to 22 carbon atoms and wherein a hydrogen atom has been removed from the \u03c9-amino group; and Z and Z 1 , independently of each other, is \u2014SO 2 \u2014Ar or \u2014CO\u2014Ar, wherein Ar is a phenyl group substituted by one or more \u2014B(OH) 2  groups and, optionally, substituted by one or more halogen atoms; with the proviso that if Z or Z 1  is \u2014SO 2 \u2014Ar, then X or X 1  is not a bond.

Metadata:
- Claim Count in Document: 3.0
- Percentile: 95.0
- Lexical Diversity: 1.15
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['12935438', '14126215', '13224538', '12673516', '15121206']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8370361488181836
- 35 USC 102 Novelty (BERT): 0.5739388590545358
- Combined Prediction Score: 0.8107264198418188
- Mean Citation Score: 445.473044
- Max Citation Score: 501.0652
- Similarity Product: 377.0160513534069

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test