PATENT CLAIM ANALYSIS

Application Number: 15918489
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["435", "007100"]

Abstract:
Disclosed are systems and methods for developing diagnostic tests (e.g., detection, screening, monitoring, and prognostic tests) based on biomarker information from legacy clinical sample sets, for which only small sample volumes (e.g., about 0.05 to about 1.0 mL or less per sample) are typically available. For example, biomarkers (e.g., about 10, 50, 100, 150, 200, 300, or more) may be detected in the clinical samples through the use of single molecule detection and each biomarker may be detected in an assay that includes about 1 or less of a legacy clinical sample.

Claim (Index 1):
A single detection means of evaluating the health state of a human subject, comprising obtaining a measurement of a least one clinical biomarker from at least one live clinical sample isolated from said human subject, and inputting said measurement(s) into a model that calculates an output value correlated to said health state, the improvement comprising using as said model an algorithm that was developed by measurement of multiple development biomarkers comprising said clinical biomarker(s) from at least one legacy clinical sample set annotated for said health state, said measurement comprising use of legacy clinical samples having a sample volume of 1 ml or less, and analyzing said measurement of multiple biomarkers for an association with said health state.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 90.0
- Lexical Diversity: 1.65217
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12300019', '13561913', '14945200', '13504720', '13253578']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6148715690046207
- 35 USC 102 Novelty (BERT): 0.5421218355481873
- Combined Prediction Score: 0.6075965956589774
- Mean Citation Score: 303.710454
- Max Citation Score: 387.223
- Similarity Product: 378.49165729278326

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test