PATENT CLAIM ANALYSIS

Application Number: 15880029
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["435", "218000"]

Abstract:
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.

Claim (Index 33):
An autoactivating type I pancreatic proelastase protein comprising an amino acid sequence which is at least 90% identical to a reference amino acid sequence consisting of the amino acid sequence of SEQ ID NO:73 linked to the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the first thirteen amino acids of the reference amino acid sequence are designated P10-P9-P8-P7-P6-P5-P4-P3-P2-P1-P1\u2032-P2\u2032-P3\u2032, wherein:\n (a) the amino acid residue at the P5 position in the protein is any natural amino acid; (b) the amino acid residue at the P4 position in the protein is any natural amino acid except glycine, lysine, phenylalanine, tyrosine, tryptophan, or arginine; (c) the amino acid residue at the P3 position in the protein is any natural amino acid except proline or glycine; (d) the amino acid residue at the P2 position in the protein is proline, alanine, leucine, isoleucine, glycine, valine, histidine, or threonine; and (e) the amino acid residue at the P1 position in the protein is alanine, leucine, valine, isoleucine, or serine.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 86.0
- Lexical Diversity: 1.68889
- Patent Class: 435.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['12746509', '12327809', '12676203', '10573821', '10014658']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6447262516045674
- 35 USC 102 Novelty (BERT): 0.6196883228681713
- Combined Prediction Score: 0.6422224587309279
- Mean Citation Score: 430.7415940000001
- Max Citation Score: 695.4899
- Similarity Product: 500.3962398135901

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test