PATENT CLAIM ANALYSIS

Application Number: 16090766
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["703", "011000"]

Abstract:
Disclosed are computational modeling methods employing RMS fluctuation values associated with energy functions to compute binding properties of a subject biomolecule and an identified target. An energy function (or force field) that relates the molecular structure of a biomolecule to an energy value, modified with terms calculated from sets of RMS fluctuation values of the biomolecule, the target and the complex, are used to identify a potential mutation or modification suitable for imparting a selected property to a biomolecule of interest. Uses of the method in the manufacture of non-native proteins having a selected modified property are also provided. Therapeutic agents (proteins, antibodies, TCRs) enzymes, etc., prepared according to the present methods are also provided. Non-native biomolecules having improved properties, for example, weaker or enhanced binding affinity in a modified TCR, are described. Enzymes, industrial reagents, and the like, created using the disclosed methods are also presented.

Claim (Index 1):
A computational protein modeling method suitable for selectively modulating an activity of an identified property of a native biomolecule of interest to provide a modified biomolecule of interest having a selected mutation, said biomolecule of interest having an identified target, the method comprising:\n obtaining a set of site-specific RMS fluctuation values for a set of sites of the native biomolecule of interest and for a set of sites of the identified target; incorporating the sets of site-specific RMS fluctuation values into an energy function; computing an interaction energy between a structure or model of the native biomolecule of interest and the identified target using the energy function; computing an interaction energy between a structure or model of the modified biomolecule of interest having a mutation or other modification and the identified target using the energy function; and determining an impact of the mutation or other modification on the binding of the biomolecule to the identified target, wherein the modulated activity of the modified biomolecule of interest is different compared to the activity of the native biomolecule of interest.

Metadata:
- Claim Count in Document: 20.0
- Percentile: 97.0
- Lexical Diversity: 1.84783
- Patent Class: 703.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15327984', '14280308', '14248919', '14249904', '15037485']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.2618149154267862
- 35 USC 102 Novelty (BERT): 0.5225065144283357
- Combined Prediction Score: 0.2878840753269412
- Mean Citation Score: 264.96863
- Max Citation Score: 305.4636
- Similarity Product: 181.4846272634983

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test