PATENT CLAIM ANALYSIS

Application Number: 15759943
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-09
Patent Classification: ["514", "04400A"]

Abstract:
Disclosed are a pharmaceutical composition for anionic drug delivery, and a preparation method therefor, the pharmaceutical composition for anionic drug delivery containing: an anionic drug as an active ingredient; a cationic compound; an amphiphilic block copolymer; and a polylactate, wherein the anionic drug formed a complex with the cationic lipid, and the complex is encapsulated within a micelle structure formed by the amphiphilic block copolymer and the polylactate.

Claim (Index 1):
A composition for delivering an anionic drug, comprising:\n the anionic drug as an active ingredient; a cationic compound; an amphiphilic block copolymer; and at least one salt of polylactic acid selected from the group consisting of the compounds of Formulae 1 to 6 as below, wherein the anionic drug forms a complex with the cationic compound by electrostatic interaction, and the complex is entrapped in the micelle structure of the amphiphilic block copolymer and the salt of polylactic acid:\n [Formula 1] \n RO\u2014CHZ\u2014[A] n \u2014[B] m \u2014COOM \n wherein A is \u2014COO\u2014CHZ\u2014; B is \u2014COO\u2014CHY\u2014, \u2014COO\u2014CH 2 CH 2 CH 2 CH 2 CH 2 \u2014 or \u2014COO\u2014CH 2 CH 2 OCH 2 , R is a hydrogen atom, or acetyl, benzoyl, decanoyl, palmitoyl, methyl or ethyl; Z and Y each are a hydrogen atom, or methyl or phenyl; M is Na, K or Li; n is an integer from 1 to 30; and m is an integer from 0 to 20;\n [Formula 2] \n RO\u2014CHZ\u2014[COO\u2014CHX] p \u2014[COO\u2014CHY\u2032] q \u2014COO\u2014CHZ\u2014COOM \n wherein X is methyl; Y\u2032 is a hydrogen atom or phenyl; p is an integer from 0 to 25, q is an integer from 0 to 25, with the proviso that p+q is an integer from 5 to 25; R is a hydrogen atom, or acetyl, benzoyl, decanoyl, palmitoyl, methyl or ethyl; M is Na, K or Li; and Z is a hydrogen atom, methyl or phenyl;\n [Formula 3] \n RO\u2014PAD-COO\u2014W-M\u2032 \n wherein W-M\u2032 is PAD is selected from the group consisting of D,L-polylactide, D-polylactide, polymandelic acid, copolymer of D,L-lactide and glycolic acid, copolymer of D,L-lactide and mandelic acid, copolymer of D,L-lactide and caprolactone, and copolymer of D,L-lactide and 1,4-dioxane-2-one; R is a hydrogen atom, or acetyl, benzoyl, decanoyl, palmitoyl, methyl or ethyl; and M is independently Na, K or Li;\n [Formula 4] \n S\u2014O\u2014PAD-COO\u2014Q \n wherein S is L is \u2014NR 1 \u2014 or \u2014O\u2014, wherein R 1  is a hydrogen atom or C 1-10  alkyl; Q is CH 3 , CH 2 CH 3 , CH 2 CH 2 CH 3 , CH 2 CH 2 CH 2 CH 3 , or CH 2 C 6 H5; a is an integer from 0 to 4; b is an integer from 1 to 10; M is Na, K or Li; and PAD is at least one selected from the group consisting of D,L-polylactide, D-polylactide, polymandelic acid, copolymer of D,L-lactide and glycolic acid, copolymer of D,L-lactide and mandelic acid, copolymer of D,L-lactide and caprolactone, and copolymer of D,L-lactide and 1,4-dioxane-2-one; wherein R\u2032 is -PAD-O\u2014C(O)\u2014CH 2 CH 2 \u2014C(O)\u2014OM, wherein PAD is selected from the group consisting of D,L-polylactide, D-polylactide, polymandelic acid, copolymer of D,L-lactide and glycolic acid, copolymer of D,L-lactide and mandelic acid, copolymer of D,L-lactide and caprolactone, and copolymer of D,L-lactide and 1,4-dioxane-2-one, M is Na, K or Li; and a is an integer from 1 to 4; and\n [Formula 6] \n YO\u2014[\u2014C(O)\u2014(CHX) a \u2014O\u2014] m \u2014C(O)\u2014R\u2014C(O)\u2014[\u2014O\u2014(CHX\u2032) b \u2014C(O)\u2014] n \u2014OZ \n wherein X and X\u2032 are independently hydrogen, C 1-10  alkyl or C 6-20  aryl; Y and Z are independently Na, K or Li; m and n are independently an integer from 0 to 95, with the proviso that 5<m+n<100; a and b are independently an integer from 1 to 6; and R is \u2014(CH 2 ) k \u2014, C 2-10  divalent alkenyl, C 6-20  divalent aryl or a combination thereof, wherein k is an integer from 0 to 10.

Metadata:
- Claim Count in Document: 4.0
- Percentile: 90.0
- Lexical Diversity: 1.925
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15137167', '14388043', '10104587', '11974196', '10483826']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7956546758333786
- 35 USC 102 Novelty (BERT): 0.5444893598196036
- Combined Prediction Score: 0.7705381442320011
- Mean Citation Score: 327.367922
- Max Citation Score: 400.70352
- Similarity Product: 339.2538217977333

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test