PATENT CLAIM ANALYSIS

Application Number: 16269628
Application Type: Utility
Filing Date: 2019-02
Publication Date: 2019-06
Patent Classification: ["514", "158000"]

Abstract:
This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

Claim (Index 15):
A method for slowing progression of aortic valve sclerosis to calcific aortic valve stenosis, wherein said method comprises administering, as the sole active ingredient for slowing said progression, a sGC agonist to a mammal identified as having aortic valve sclerosis, wherein said sGC agonist slows progression of aortic valve sclerosis to calcific aortic valve stenosis within said mammal, and wherein the sGC agonist is BAY 58-2667 (4-[((4-Carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid hydrochloride), BAY 41-2272 (3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine), BAY-41-8543 (2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine), or BAY 63-2521 (methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate).

Metadata:
- Claim Count in Document: 34.0
- Percentile: 99.0
- Lexical Diversity: 1.39535
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15702461', '14652903', '14861428', '12908467', '12227872']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7857573570000689
- 35 USC 102 Novelty (BERT): 0.6654482980928146
- Combined Prediction Score: 0.7737264511093435
- Mean Citation Score: 387.797056
- Max Citation Score: 640.1366
- Similarity Product: 583.0631874724626

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test