PATENT CLAIM ANALYSIS

Application Number: 16197106
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["424", "454000"]

Abstract:
The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 μg/kg body weight/minute and 20 μg/kg body weight/minute.

Claim (Index 1):
A method for treating a subject with heart failure or a stage, class or manifestation of heart failure or at risk of developing or exhibiting symptoms of heart failure or a subject with pulmonary hypertension, said method comprising administering to the subject an oral controlled-release formulation comprising:\n (i) a core comprising a 5-(pyridinyl)-2-(1H)-pyridinone compound of Formula (I): wherein:\n R 1  is hydrogen, \u2014C 1 -C 6  alkyl or \u2014C 1 -C 6  alkyl-OH; \n R 2  is \u2014C 1 -C 6  alkyl; \n R 3  is hydrogen, \u2014NH 2 , \u2014CN, \u2014C(O)NH 2 , halo, \u2014NH(C 1 -C 6  alkyl), \u2014N(C 1 -C 6  alkyl) 2 , \u2014NH(COC 1 -C 6  alkyl), \u2014CO 2 H or \u2014CO 2 C 1 -C 6  alkyl; and \n PY is 4-, 3- or 2-pyridinyl optionally substituted with one or two C 1 -C 6  alkyl groups; \n or a pharmaceutically acceptable salt thereof; \n one or more polymers and one or more excipients; and (ii) a sustained release coating;\n wherein the formulation permits release of the compound of Formula (I) in an amount to achieve steady state plasma levels effective to ameliorate symptoms of heart failure; wherein release of the compound of Formula (I) from the formulation is in the range of between 0.1 \u03bcg/kg body weight/minute to 20 \u03bcg/kg body weight/minute.

Metadata:
- Claim Count in Document: 1.0
- Percentile: 98.0
- Lexical Diversity: 1.6383
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['16029239', '14238961', '15538123', '10586209', '12467214']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6905873420213845
- 35 USC 102 Novelty (BERT): 0.564885287000224
- Combined Prediction Score: 0.6780171365192684
- Mean Citation Score: 304.942146
- Max Citation Score: 452.5346
- Similarity Product: 337.1505789206743

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test