PATENT CLAIM ANALYSIS

Application Number: 16403183
Application Type: Utility
Filing Date: 2019-05
Publication Date: 2019-08
Patent Classification: ["424", "009200"]

Abstract:
A composition containing biocompatible hydrogel encapsulating mammalian cells and anti-inflammatory drugs is disclosed. The encapsulated cells have reduced fibrotic overgrowth after implantation in a subject. The compositions contain a biocompatible hydrogel having encapsulated therein mammalian cells and anti-inflammatory drugs or polymeric particles loaded with anti-inflammatory drugs. The anti-inflammatory drugs are released from the composition after transplantation in an amount effective to inhibit fibrosis of the composition for at least ten days. Methods for identifying and selecting suitable anti-inflammatory drug-loaded particles to prevent fibrosis of encapsulated cells are also described. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Claim (Index 9):
The composition of  claim 1 , wherein the biocompatible, biodegradable polymer is selected from the group consisting of polylactic acid (PLA), polyglycolic acid (PGA), poly(lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL), polyhydroxyalkanoate (PHA), poly(lactic acid)-poly(ethylene oxide) (PLA-PEG), polyanhydrides, poly(ester anhydrides), and copolymers and blends thereof.

Metadata:
- Claim Count in Document: 32.0
- Percentile: 100.0
- Lexical Diversity: 1.86154
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15831570', '13400382', '13831250', '14776639', '14394147']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7821973261149577
- 35 USC 102 Novelty (BERT): 0.6506352126593672
- Combined Prediction Score: 0.7690411147693987
- Mean Citation Score: 487.78897
- Max Citation Score: 620.57025
- Similarity Product: 595.6095691680907

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test