PATENT CLAIM ANALYSIS

Application Number: 16072686
Application Type: Utility
Filing Date: 2019-03
Publication Date: 2019-06
Patent Classification: ["514", "471000"]

Abstract:
The use of an NLRP3 inhibitor compound is described in the treatment of inflammatory skin disorders, in particular psoriasis and atopic dermatitis.

Claim (Index 17):
The method of claim  1 , wherein the compound is selected from the group consisting of:\n N-((4-chloro-2,6-diisopropylphenyl)carbamoyl)-3-(2-hydroxypropan-2-yl)benzenesulfonamide; N-((2,6-diisopropylphenyl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide; N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide; 4-(1,3-dioxolan-2-yl)-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)furan-2-sulfonamide; N-((1,2,3,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide; N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)thiophene-2-sulfonamide; N-((2,6-diisopropylphenyl)carbamoyl)-4-(2-hydroxypropan-2-yl)thiophene-2-sulfonamide; 4-acetyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)thiophene-2-sulfonamide; N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1H-benzo[d]imidazole-5-sulfonamide; N-((8-chloro-1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide; 4-acetyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)furan-2-sulfonamide; N-((8-fluoro-1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide; N-((4-fluoro-2,6-diisopropylphenyl)carbamoyl)-3-(2-hydroxypropan-2-yl)benzenesulfonamide; 6-fluoro-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1H-benzo[d]imidazole-5-sulfonamide; N-((4-chloro-2,6-diisopropylphenyl)carbamoyl)-1H-indole-6-sulfonamide; N-((4-chloro-2,6-diisopropylphenyl)carbamoyl)-5-fluoro-1H-indole-6-sulfonamide; N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1H-indole-6-sulfonamide; 5-fluoro-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-1H-indole-6-sulfonamide; N-((4-chloro-2,6-diisopropylphenyl)carbamoyl)-2-fluoro-5-(2-methyl-1,3-dioxolan-2-yl)benzenesulfonamide; and 2-fluoro-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-5-(2-methyl-1,3-dioxolan-2-yl)benzenesulfonamide; or the pharmaceutically acceptable salt, solvate or hydrate thereof.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 99.0
- Lexical Diversity: 1.09091
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15551264', '14380078', '12992766', '10559322', '12937006']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7918230277280107
- 35 USC 102 Novelty (BERT): 0.491837859505965
- Combined Prediction Score: 0.7618245109058062
- Mean Citation Score: 225.059508
- Max Citation Score: 256.63382
- Similarity Product: 213.4588294236756

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test