PATENT CLAIM ANALYSIS

Application Number: 15964423
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-09
Patent Classification: ["424", "093200"]

Abstract:
Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.

Claim (Index 1):
A method of immunotherapy for treating cancer in a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising a genetically-modified human T cell and a pharmaceutically acceptable carrier, wherein said genetically-modified human T cell comprises in its genome a modified human T cell receptor (TCR) alpha constant region gene, wherein said modified human TCR alpha constant region gene comprises from 5\u2032 to 3\u2032:\n (a) a 5\u2032 region of a human TCR alpha constant region gene which is endogenous to said T cell; \n (b) an exogenous nucleic acid sequence encoding a chimeric antigen receptor; and \n (c) a 3\u2032 region of said human TCR alpha constant region gene which is endogenous to said T cell; \n wherein said chimeric antigen receptor comprises a ligand-binding domain having specificity for an antigen present on a cancer cell, and wherein said genetically-modified human T cell expresses said chimeric antigen receptor and exhibits reduced cell-surface expression of the endogenous T cell receptor when compared to unmodified control cells.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 91.0
- Lexical Diversity: 1.51163
- Patent Class: 424.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15864984', '15865089', '15964446', '15865075', '15864947']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8536046828208456
- 35 USC 102 Novelty (BERT): 0.7283507019494895
- Combined Prediction Score: 0.84107928473371
- Mean Citation Score: 799.221974
- Max Citation Score: 800.19635
- Similarity Product: 789.6228479100943

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test