PATENT CLAIM ANALYSIS

Application Number: 16016290
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2018-11
Patent Classification: ["514", "217050"]

Abstract:
Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders.

Claim (Index 56):
A method of treating a pulmonary disease or disorder in a subject in need thereof, the method comprising administrating to the subject an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: X is \u2014O\u2014, \u2014NH\u2014 or \u2014S\u2014; n1, n2, n6, n7, n8, and n9 are independently an integer from 0 to 4; m1, m6, m7, m8, m9, v1, v6, v7, v8, and v9 are each independently 1 or 2; R 1  is hydrogen, halogen, \u2014CX 1.1 3 , \u2014CHX 1.1 2 , \u2014CH 2 X 1.1 , \u2014CN, \u2014SO n1 R 1A , \u2014SO v1 NR 1B R 1C , \u2014NHNR 1B R 1C , \u2014ONR 1B R 1C , \u2014NHC(O)NHNR 1B R 1C , \u2014NHC(O)NR 1B R 1C , \u2014N(O) m1 , \u2014NR 1B R 1C , \u2014C(O)R 1D , \u2014C(O)OR 1D , \u2014C(O)NR 1B R 1C , \u2014OR 1A , \u2014NR 1B SO 2 R 1A , \u2014NR 1B C(O)R 1D , \u2014NR 1B C(O)OR 1D , \u2014NR 1B OR 1D , \u2014OCX 1.1 3 , \u2014OCHX 1.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 2  is hydrogen, \u2014CX 2.1 3 , \u2014CHX 2.1 2 , \u2014(CH 2 ) n2 CX 2.1 3 , \u2014OR 2A , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or haloalkyl; R 3  is hydrogen, \u2014C(O)R 3D , \u2014C(O)NHNR 3B R 3C , \u2014C(O)OR 3D , \u2014SO 2 R 3A , \u2014C(O)NR 3B R 3C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; R 4  is hydrogen, \u2014C(O)R 4D , \u2014C(O)NHNR 4B R 4C , \u2014C(O)OR 4D , \u2014SO 2 R 4A , \u2014C(O)NR 4B R 4C -substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, wherein R 3  and R 4  may optionally be joined to form, together with the atoms to which they are attached, a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl, wherein R 3  and R 4  are optionally be joined to form, together with the atoms to which they are attached, a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 5  is hydrogen, \u2014C(O)R 5D , \u2014C(O)NHNR 5B R 5C , \u2014C(O)OR 5D , \u2014SO 2 R 5A , \u2014C(O)NR 5B R 5C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, wherein R 3  and R 4  may optionally be joined to form, together with the atoms to which they are attached, a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R 6  is hydrogen, halogen, \u2014CX 6.1 3 , \u2014CHX 6.1 2 , \u2014CH 2 X 6.1 , \u2014CN, \u2014SO n6 R 6A , \u2014SO v6 NR 6B R 6C , \u2014NHNR 6B R 6C , \u2014ONR 6B R 6C , \u2014NHC(O)NHNR 6B R 6C , \u2014NHC(O)NR 6B R 6C , \u2014N(O) m6 , \u2014NR 5B R 5C , \u2014C(O)R 6D , \u2014C(O)OR 6D , \u2014C(O)NR 6B R 6C , \u2014OR 6A , \u2014NR 6B SO 2 R 6A , \u2014NR 6B C(O)R 6C , \u2014NR 6B C(O)OR 6D , \u2014NR 6B OR 6D , \u2014OCX 6.1 3 , \u2014OCHX 6.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 7  is hydrogen, halogen, \u2014CX 7.1 3 , \u2014CHX 7.1 2 , \u2014CH 2 X 7.1 , \u2014CN, \u2014SO n7 R 7A , \u2014SO v7 NR 7B R 7C , \u2014NHNR 7B R 7C , \u2014ONR 7B R 7C , \u2014NHC(O)NHNR 7B R 7C , \u2014NHC(O)NR 7B R 7C , \u2014N(O) m7 , \u2014NR 7B R 7C , \u2014C(O)R 7D , \u2014C(O)OR 7D , \u2014C(O)NR 7B R 7C , \u2014OR 7A , \u2014NR 7B SO 2 R 7A , \u2014NR 7A C(O)R 7C , \u2014NR 7B C(O)OR 7D , \u2014NR 7B OR 7D , \u2014OCX 7.1 3 , \u2014OCHX 7.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 8  is hydrogen, halogen, \u2014CX 8.1 3 , \u2014CHX 8.1 2 , \u2014CH 2 X 8.1 , \u2014CN, \u2014SO n8 R 8A , \u2014SO v8 NR 8B R 8C , \u2014NHNR 8B R 8C , \u2014ONR 8B R 8C , \u2014NHC(O)NHNR 8B R 8C , \u2014NHC(O)NR 8B R 8C , \u2014N(O) m8 , \u2014NR 8B R 8C , \u2014C(O)R 8D , \u2014C(O)OR 8D , \u2014C(O)NR 8B R 8C , \u2014OR 8A , \u2014NR 8B SO 2 R 8A , \u2014NR 8B C(O)R 8D , \u2014NR 8B C(O)OR 8D , \u2014NR 8B OR 8D , \u2014OCX 8.1 3 , \u2014OCHX 8.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 9  is hydrogen, halogen, \u2014CX 9.1 3 , \u2014CHX 9.1 2 , \u2014CH 2 X 9.1 , \u2014CN, \u2014SO n9 R 9A , \u2014SO v9 NR 9B R 9C , \u2014NHNR 9B R 9C , \u2014ONR 9B R 9C , \u2014NHC(O)NHNR 9B R 9C , \u2014NHC(O)NR 9B R 9C , \u2014N(O), \u2014NR 9B R 9C , \u2014C(O)R 9D , \u2014C(O)OR, \u2014C(O)NR 9B R 9C , \u2014OR 9A , \u2014NR 9B SO 2 R 9A , \u2014NR 9B C(O)R 9D , \u2014NR 9B C(O)OR 9D , \u2014NR 9B OR 9D , \u2014OCX 9.1 3 , \u2014OCHX 9.1 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 1  and R 6 , R 6  and R 7 , R 1  and R 9 , or R 8 , and R 9  are optionally joined to form, together with the atoms to which they are attached, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 1A , R 1B , R 1C , R 1D , R 2A , R 2B , R 2C , R 2D , R 3A , R 3B , R 3C , R 3D , R 4A , R 4B , R 4C , R 4D , R 5A , R 5B , R 5C , R 5D , R 6A , R 6B , R 6C , R 6D , R 7A , R 7B , R 7C , R 7D , R 8A , R 8B , R 8C , R 8D , R 9A , R 9B , R 9C  and R 9D  are independently hydrogen, halogen, \u2014CF 3 , \u2014CCl 3 , \u2014CBr 3 , \u2014CBr 3 , \u2014CI 3 , \u2014OH, \u2014NH 2 , \u2014COOH, \u2014CONH 2 , \u2014NO 2 , \u2014SH, \u2014SO 3 H, \u2014SO 4 H, \u2014SO 2 NH 2 , \u2014NHNH 2 , \u2014ONH 2 , \u2014NHC(O)NHNH 2 , \u2014NHC(O)NH 2 , \u2014NHSO 2 H, \u2014NHC(O)H, \u2014NHC(O)\u2014OH, \u2014NHOH, \u2014OCF 3 , \u2014OCCl 3 , \u2014OCBr 3 , \u2014OCI 3 , \u2014OCHF 2 , \u2014OCHCl 2 , \u2014OCHBr 2 , \u2014OCHI 2 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 1B , R 1C , R 2B , R 2C , R 3B , R 3C , R 4B , R 4C , R 5B , R 5C , R 6B , R 6C , R 7B , R 7C , R 8B , R 8C , R 9B  and R 9C  substituents bonded to the same nitrogen atom may optionally be joined to form, together with the atoms to which they are attached, a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; and X 1.1 , X 2.1 , X 6.1 , X 7.1 , X 8.1  and X 9.1  are independently \u2014Cl, \u2014Br, \u2014I or \u2014F; with the proviso that when X is \u2014O\u2014; R 2  is \u2014(CH 2 ) n2 CX 2.1 3 ; n2 is 1; X 21  is fluorine; R 3  is hydrogen; and R 1  is \u2014CH 3 , then R 6  is not \u2014NO 2 ; and when X is \u2014O\u2014; R 2  is \u2014(CH 2 ) n2 CX 2.1 3 ; n2 is 1; X 21  is fluorine; R 3  is hydrogen; and R 1  is \u2014CH 3 , then R 9  is not \u2014NO 2 .

Metadata:
- Claim Count in Document: 23.0
- Percentile: 94.0
- Lexical Diversity: 1.21053
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15662861', '15700040', '15757238', '15214282', '15760959']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8463808056038716
- 35 USC 102 Novelty (BERT): 0.6703254358773004
- Combined Prediction Score: 0.8287752686312145
- Mean Citation Score: 616.71942
- Max Citation Score: 802.6446
- Similarity Product: 634.6564582241892

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test