PATENT CLAIM ANALYSIS

Application Number: 15948798
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-08
Patent Classification: ["506", "004000"]

Abstract:
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.

Claim (Index 13):
A method of selectable recursive genetic engineering comprising\n a) contacting cells comprising a nucleic acid-guided nuclease with a polynucleotide comprising a recorder cassette, said recorder cassette comprising\n i) a nucleic acid sequence that recombines into a unique landing site incorporated during a previous round of engineering, wherein the nucleic acid sequence comprises a barcode; and \n ii) a guide RNA compatible with the nucleic acid-guided nuclease that targets the unique landing site; and \n b) allowing the nucleic acid-guided nuclease to edit the unique landing site, thereby incorporating the barcode into the unique landing site; wherein the nucleic acid-guided nuclease comprises amino acid sequence SEQ ID NO: 2 or SEQ ID NO: 7.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 91.0
- Lexical Diversity: 2.07407
- Patent Class: 506.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15632222', '15948793', '15632001', '15631989', '15896433']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6147435117070329
- 35 USC 102 Novelty (BERT): 0.6905502147031255
- Combined Prediction Score: 0.6223241820066421
- Mean Citation Score: 534.756
- Max Citation Score: 702.1871
- Similarity Product: 692.2061852814197

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test