PATENT CLAIM ANALYSIS

Application Number: 16067319
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["435", "006110"]

Abstract:
The invention relates to a method and means for diagnosing tumors, in particular for an early diagnosis (prevention) and for differentiating between benign and malignant tumors using a PCR, in particular in bodily fluids. The method according to the invention is characterized by a combination of a pre-amplification process using a PCR, wherein methylated DNA sequences are amplified more strongly than non-methylated DNA sequences, and a subsequent quantification process using a special digital PCR, in which significantly more DNA is used than normally in the prior art. As comparison data indicates, the invention advantageously allows a clear reliable conclusion as to whether a malignant tumor disease is present or not. The invention is suitable for screening (prevention), monitoring the progress of a tumor disease, in particular to order to exclude a minimal residual disease (MRD), and for a differential diagnosis between malignant carcinoma and benign tumors.

Claim (Index 5):
Method according to  claim 1 , wherein methylated and unmethylated sequences in the gene(s) AOX-1, SERPINE-1, thrombomodulin and/or septin-9 are additionally pre-amplified in step b) and the primers are selected accordingly, and the methylated and unmethylated DNA sequences in these genes are additionally quantified in step c).

Metadata:
- Claim Count in Document: 5.0
- Percentile: 94.0
- Lexical Diversity: 1.94118
- Patent Class: 435.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14079649', '12159081', '11884406', '13224024', '12219378']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.675646771573561
- 35 USC 102 Novelty (BERT): 0.5333757817502353
- Combined Prediction Score: 0.6614196725912285
- Mean Citation Score: 361.254908
- Max Citation Score: 377.0466
- Similarity Product: 277.8760583969593

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 0

Dataset: test