PATENT CLAIM ANALYSIS

Application Number: 16002918
Application Type: Utility
Filing Date: 2018-06
Publication Date: 2019-01
Patent Classification: ["424", "184100"]

Abstract:
The present application relates to the use of bacterial minicells as targeted delivery agents in vivo and in vitro. Described herein are genetically engineered eubacterial minicells designed to preferentially target and deliver therapeutically relevant agents using a minicell surface coupling molecule capable of binding and displaying antibodies or other Fc-containing targeting moiety fusions and conjugates.

Claim (Index 30):
The method of  claim 29 , wherein said protein toxin is selected from the group consisting of gelonin, diphtheria toxin fragment A, diphtheria toxin fragment A/B, tetanus toxin,  E. coli  heat labile toxin LTI,  E. coli  heat labile toxin LTII, cholera toxin,  C. perfringes  iota toxin,  Pseudomonas  exotoxin A, shiga toxin, anthrax toxin, MTX ( B. sphaericus  mosquilicidal toxin), perfringolysin O, streptolysin, barley toxin, mellitin, anthrax toxins LF and EF, adenylate cyclase toxin, botulinolysin B, botulinolysin E3, botulinolysin C, botulinum toxin A, cholera toxin,  clostridium  toxins A, B, and alpha, ricin, shiga A toxin, shiga-like A toxin, cholera A toxin, pertussis S1 toxin,  E. coli  heat labile toxin (LTB), pH stable variants of listeriolysin O, thermostable variants of listeriolysin O, pH and thermostable variants of listeriolysin O, streptolysin O, streptolysin O c, streptolysin O e, sphaericolysin, anthrolysin O, cereolysin, thuringiensilysin O, weihenstephanensilysin, alveolysin, brevilysin, butyriculysin, tetanolysin O, novyilysin, lectinolysin, pneumolysin, mitilysin, pseudopneumolysin, suilysin, intermedilysin, ivanolysin, seeligeriolysin O, vaginolysin, pyolysin, and any combination thereof.

Metadata:
- Claim Count in Document: 53.0
- Percentile: 94.0
- Lexical Diversity: 1.1875
- Patent Class: 424.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['13397313', '15425181', '15044403', '11211098', '14152979']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7128883063873523
- 35 USC 102 Novelty (BERT): 0.6146513101146079
- Combined Prediction Score: 0.7030646067600779
- Mean Citation Score: 365.160398
- Max Citation Score: 559.9877299999998
- Similarity Product: 488.5335547176735

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test