PATENT CLAIM ANALYSIS

Application Number: 16399821
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-10
Patent Classification: ["514", "233800"]

Abstract:
The present invention relates generally to therapeutics targeting the bacterium  Porphyromonas gingivalis , including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with  P. gingivalis  infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.

Claim (Index 46):
A method for treating periodontal disease, the method comprising administering to a subject an effective amount of a compound according to Formula I: or a pharmaceutically acceptable salt thereof, wherein: Z is halogen-substituted aryloxymethyl-carbonyl; A is \u2014CH 2 \u2014; B, D, R 1 , and R 2  are hydrogen; R 3  is selected from the group consisting of C 6-10  aryl, 5-to-12 membered heteroaryl, C 3-8  cycloalkyl, 5-to-12 membered saturated heterocyclyl, and -L-R 5 , wherein L is selected from the group consisting of \u2014O\u2014, \u2014NR\u2014, C 1-4  alkylene, and 2- to 4-membered heteroalkylene, wherein R is selected from the group consisting of hydrogen and C 1-8  alkyl, R 5  is selected from the group consisting of C 6-10  aryl, 5-to-12 membered heteroaryl, C 3-8  cycloalkyl, and 5-to-12 membered saturated heterocyclyl, and wherein R 3  is optionally substituted with one or more substituents selected from the group consisting of halo, \u2014CN, \u2014NO 2 , \u2014N 3 , \u2014OH, R a , R b , \u2014OR a , \u2014OR b , \u2014(CH 2 ) k C(O)R c , \u2014NR d (CH 2 ) u C(O)R c , \u2014O(CH 2 ) u C(O)R c , \u2014(CH 2 ) k CONR d R d , \u2014(CH 2 ) k NR d C(O)R c , \u2014NR d (CH 2 ) u CONR d R d , \u2014NR d (CH 2 ) u NR d C(O)R c , \u2014O(CH 2 ) u CONR d R d , \u2014O(CH 2 ) u NR d C(O)R c , \u2014(CH 2 ) k S(O) 2 NR d R d , \u2014(CH 2 ) k NR d S(O) 2 R c , \u2014(CH 2 ) k S(0) 2 R c , \u2014(CH 2 ) k S(O)R c , \u2014(CH 2 ) k SR d , \u2014NR d (CH 2 ) u S(O) 2 NR d R d , \u2014NR d (CH 2 ) u NR d S(O) 2 R c , \u2014NR d (CH 2 ) u S(O) 2 R c , \u2014NR d (CH 2 ) u S(O)R c , \u2014NR d (CH 2 ) u SR d , \u2014O(CH 2 ) u S(O) 2 NR d R d , \u2014O(CH 2 ) u NR d S(O) 2 R c , \u2014O(CH 2 ) u S(O) 2 R c , \u2014O(CH 2 ) u S(O)R c , and \u2014O(CH 2 ) u SR c , wherein: each R a  is independently selected from the group consisting of C 1-4  alkyl and C 1-4  haloalkyl, each R b  is independently selected from the group consisting of C 3-6  cycloalkyl, C 3-6  halocycloalkyl, C 6-10  aryl, 5-to-12 membered heteroaryl, and 5-to-12 membered saturated heterocyclyl, each R c  is independently selected from the group consisting of \u2014OH, C 1-8  alkyl, C 1-8  haloalkyl, C 3-8  cycloalkyl, C 3-8  halocycloalkyl, C 6-10  aryl, (C 6-10  aryl)-(C 1-8  alkyl), 5-to-12 membered heteroaryl, and 5-to-12 membered saturated heterocyclyl, each R d  is independently selected from the group consisting of hydrogen and C 1-8  alkyl, each subscript k is independently selected from 0, 1, 2, 3, 4, 5, and 6, and each subscript u is independently selected from 1, 2, 3, 4, 5, and 6; and R 4  is selected from the group consisting of hydrogen, halogen, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, and C 1-4  haloalkoxy; provided that when A is \u2014CH 2 \u2014, and B and D are hydrogen, then R 3  is other than (2-phenyl)ethyl or substituted (2-phenyl)ethyl.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 100.0
- Lexical Diversity: 1.28302
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['14875416', '15996660', '15683348', '12446763', '11431696']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7937636016945776
- 35 USC 102 Novelty (BERT): 0.5948195741509276
- Combined Prediction Score: 0.7738691989402127
- Mean Citation Score: 442.096682
- Max Citation Score: 570.5591400000002
- Similarity Product: 436.40182813819183

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test