PATENT CLAIM ANALYSIS

Application Number: 16343271
Application Type: Utility
Filing Date: 2019-04
Publication Date: 2019-08
Patent Classification: ["546", "153000"]

Abstract:
The present application provides a quinolyl-substituted carboxylic acid compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, as well as a method for preparing the compound, a use of the compound, and a formulation containing the quinolyl-substituted carboxylic acid compound or the pharmaceutically acceptable salt thereof. This type of compounds are inhibitors for AXL and/or VEGFR2 protein kinase, and can be used to treat diseases caused by abnormality of the two protein kinases, such as, tumor, etc.;

Claim (Index 1):
A quinolyl-substituted carboxylic acid compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, wherein V 1  and V 2  are each independently selected from hydrogen, deuterium, halogen, C 1-6  alkyl and C 1-6  alkoxy; R is hydrogen, C 1-12  alkyl, or C 1-12  alkoxy, and hydrogen of R is selectively substituted by G 1 ; L is C 1-12  alkylene, and hydrogen of L is selectively substituted by G 2 ; M is selected from: (a) hydrogen, deuterium, C 2-12  alkyl, C 3-12  cycloalkyl, C 6-12  aryl, C 5-12  heteroaryl, and C 3-12  heteroalicyclic group, wherein hydrogen of M is selectively substituted by G 3 ; or (b) monovalent, divalent, trivalent, and tetravalent metal ions, preferably monovalent and divalent metal ions, and more preferably lithium ion, sodium ion, potassium ion, rubidium ion, cesium ion, magnesium ion, calcium ion, strontium ion, and barium ion; or (c) ammonium ion and an organic amine being protonated, the organic amine including, but not limited to, aliphatic amines substituted with C 1-12  alkyl, C 3-12  cycloalkyl, or C 3-12  heteroalicyclic group, the aliphatic amines being selectively substituted with one or more halogens or hydroxyls; wherein G 1 , G 2  and G 3  are each independently selected from hydrogen, deuterium, \u2014CN, \u2014CF 3 , \u2014CO 2 H, halogen, C 1-12  alkyl, C 3-12  cycloalkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 6-12  aryl, C 5-12  heteroaryl, C 3-12  heteroalicyclic group, R 1 O\u2014, R 1 R 2 N\u2014, R 1 S(\u2550O) m \u2014, R 1 R 2 NS(\u2550O) m \u2014, R 3 C(\u2550O)\u2014, R 1 R 2 NC(\u2550O)\u2014, R 1 OC(\u2550O)\u2014, R 3 C(\u2550O)O\u2014, R 1 R 2 NC(\u2550O)O\u2014, R 3 C(\u2550O)NR 1 \u2014, R 1 R 2 NC(\u2550O)NR 4 \u2014, R 1 OC(\u2550O)NR 4 \u2014, R 1 S(\u2550O) m NR 4 \u2014, R 1 R 2 NS(\u2550O) m NR 4 \u2014, R 1 R 2 NC(\u2550NR 5 )NR 4 \u2014, R 1 R 2 NC(\u2550CHNO 2 )NR 4 \u2014, R 1 R 2 NC(\u2550N\u2014CN)NR 4 \u2014, R 1 R 2 NC(\u2550NR 5 )\u2014, R 1 S(\u2550O)(\u2550NR 5 )NR 4 \u2014, and R 1 R 2 NS(\u2550O)(\u2550NR 5 )\u2014; R 1 , R 2 , R 3 , R 4  and R 5  are each independently selected from hydrogen, deuterium, C 1-12  alkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 3-12  cycloalkyl, C 6-12  aryl, C 5-12  heteroaryl, and C 3-12  heteroalicyclic group; R 1  and R 2 , when being bonded to a same nitrogen atom, form a C 3-12  heteroalicyclic ring together with the nitrogen atom, wherein the C 3-12  heteroalicyclic ring selectively contains a hetero atom of O, N, S(\u2550O) m ; hydrogen of R 1 , R 2 , R 3 , R 4  and R 5  is selectively substituted by halogen, CN, C 1-12  alkyl or C 3-12  cycloalkyl; and m is from 0 to 2.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 100.0
- Lexical Diversity: 1.58621
- Patent Class: 546.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['14345922', '13819560', '13308287', '10420466', '12228421']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.804835572840459
- 35 USC 102 Novelty (BERT): 0.5181624524116173
- Combined Prediction Score: 0.7761682607975748
- Mean Citation Score: 286.6710240000001
- Max Citation Score: 328.88113
- Similarity Product: 257.1802818942189

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test