PATENT CLAIM ANALYSIS

Application Number: 16091577
Application Type: Utility
Filing Date: 2018-10
Publication Date: 2019-05
Patent Classification: ["549", "467000"]

Abstract:
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Claim (Index 39):
A compound of formula (I) or a pharmaceutically acceptable salt thereof wherein:\n R 1  is \u2014C 1-3 alkyl or cyclopropyl; \n R 2  is \u2014C 0-3 alkyl-cycloalkyl, wherein the cycloalkyl group is optionally substituted with one, two or three R 5  groups which may be the same or different; \n R 2  is \u2014C 0-4 alkyl-heterocyclyl or \u2014(CH 2 ) p O-heterocyclyl wherein each heterocyclyl is optionally substituted by one or two R 9  groups which may be the same or different; or \n R 2  is H, \u2014CH 3 , C 2-6 alkyl optionally substituted by up to five fluoro, \u2014C 2-6 alkylOR 13 , \u2014C 2-6 alkylNR 11 R 12 , \u2014(CH 2 ) m SO 2 C 1-3 alkyl, \u2014(CH 2 ) m SO 2 NR 11 R 12 , \u2014(CH 2 ) m C(O)NR 11 R 12 , \u2014(CH 2 ) m CN, \u2014(CH 2 ) m CO 2 R 13 , \u2014(CH 2 ) m NHCO 2 C 1-4 alkyl \u2014(CH 2 ) m NHC(O)C 1-4 alkyl or \u2014(CH 2 ) n heteroaryl, wherein heteroaryl is optionally substituted by one or two R 14  groups which may be the same or different; \n R 3  is phenyl optionally substituted with one, two or three R 7  groups which may be the same or different; \n R 4  is \u2014C 1-3 alkyl, \u2014CH 2 OR 6  or \u2014CH 2 F; \n each R 5  is independently halo, \u2014C 0-6 alkyl-R 8 , \u2014O\u2014C 2-6 alkyl-R 8 , \u2014CN or \u2014SO 2 C 1-3 alkyl; \n R 6  is \u2014H or C 1-3 alkyl; \n each R 7  is independently -halo, \u2014C 1-4 alkyl, \u2014C 0-3 alkyl-OR 10 , \u2014C 0-3 alkyl-NR 15 R 16 , \u2014C 0-3 alkyl-CONR 15 R 16 , CN or \u2014SO 2 R 17 ; \n R 8  is \u2014H, \u2014OR 10a , \u2014NR 18 R 19  or heteroaryl; \n each R 9  is independently halo, C 1-4 alkyl, cyclopropyl, cyclobutyl, \u2014CH 2 CF 3 , \u2014CH 2 CHF 2 , \u2014CH 2 CH 2 F,\u2014OCH 2 CH 2 OR 13 , \u2014C 0-3 alkylOR 13 , \u2014C 0-3 alkylNR 11 R 12 , \u2014NHCH 2 CH 2 OR 13 , \u2014NHCO 2 R 13 , oxo, \u2014C(O)R 13 , \u2014C(O)OR 13  or \u2014C(O)NR 11 R 12 ; \n R 10a  is \u2014H, \u2014C 1-3 alkyl, \u2014C 2-3 alkylNR 11 R 12 , or \u2014C 2-3 alkylOH; \n R 10  is \u2014H, \u2014C 1-3 alkyl, \u2014C 2-3 alkylNR 15 R 16 , or \u2014C 2-3 alkylOH; \n R 11  and R 12  are each independently selected from \u2014H and \u2014C 1-3 alkyl; \n or R 11  and R 12  may join together with the nitrogen to which they are attached, to form a 4 to 7-membered heterocyclyl group optionally substituted by one or two substituents independently selected from \u2014C 1-3 alkyl, \u2014OH and F; \n R 13  is \u2014H or C 1-4 alkyl; \n each R 14  is independently halo, C 1-4 alkyl, cyclopropyl, cyclobutyl or \u2014OR 13 ; \n R 15  and R 16  are each independently selected from \u2014H and \u2014C 1-3 alkyl; \n or R 15  and R 16  may join together with the nitrogen to which they are attached, to form a 4 to 7-membered heterocyclyl group optionally substituted by one or two substituents independently selected from \u2014C 1-3 alkyl, \u2014OH and F; \n R 17  is \u2014C 1-3 alkyl or \u2014NR 15 R 16 ; \n R 18  and R 19  are each independently selected from \u2014H, \u2014C(O)OC(CH 3 ) 3 , \u2014C 1-6 alkyl, cycloalkyl, heterocyclyl, \u2014C 2-3 alkylNR 13 COC 1-3 alkyl, C 2-3 alkylNR 15 R 16 , and \u2014C 2-3 alkyl-O\u2014C 1-3 alkyl, wherein the \u2014C 1-6 alkyl and cycloalkyl may be optionally substituted by one, two or three fluoro; \n or R 18  and R 19  may join together with the nitrogen to which they are attached, to form a 4 to 7-membered heterocyclyl group optionally substituted by one or two substituents independently selected from \u2014C 1-3 alkyl, \u2014OH and F; \n m is an integer selected from 2, 3 and 4; \n p is an integer selected from 2, 3 and 4; \n n is an integer selected from 0, 1, 2, 3 and 4.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 97.0
- Lexical Diversity: 1.125
- Patent Class: 549.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: True
- Related Applications: ['15757199', '15762229', '15766222', '15045679', '14546896']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7470503239027846
- 35 USC 102 Novelty (BERT): 0.5680817820226475
- Combined Prediction Score: 0.7291534697147708
- Mean Citation Score: 375.658508
- Max Citation Score: 444.02606
- Similarity Product: 364.2311288984537

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test