PATENT CLAIM ANALYSIS

Application Number: 16074449
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2019-01
Patent Classification: ["514", "312000"]

Abstract:
The present invention relates to use of pyrroloquinoline quinone (PQQ), a derivative and/or a salt thereof of formula (I) in the preparation of a drug for treating and/or preventing primary Sjogren's syndrome, secondary Sjogren's syndrome as well as dry mouth, dry eye and multiple system damages accompanied by the involvement of other exocrine glands and other organs outside the glands caused by Sjogren's syndrome. In formula (I), R1, R2 and R3 being same or different, each independently representing lower alkyl, lower alkenyl, lower alkynyl, aralkyl, alkaryl, phenyl, a hydrogen atom, sodium atom or a potassium atom; and PQQ or pharmaceutical combinations of PQQ combined with active vitamin D, NAC, resveratrol, epigallocatechin gallate, curcumin, anthocyanin, vitamin E, vitamin C, or vitamin D and the like. The drug and the pharmaceutical combinations can treat Sjogren's syndrome and associated diseases which are derivative of Sjogren's syndrome. The present invention can remove excess oxygen radicals in the body, inhibit NF-kB activation caused by oxidative stress, and inhibit autoimmunity, thereby reducing the inflammatory response of Sjogren's syndrome.

Claim (Index 9):
The pharmaceutical composition according to  claim 5 , further comprising any one of the following substances or a mixture of any two or more of the following substances in any ratios: N-acetyl-L-cysteine, resveratrol, Epigallocatechin gallate, curcumin, anthocyanins, tea polyphenols, vitamin B12, vitamin E, vitamin C or vitamin D.

Metadata:
- Claim Count in Document: 5.0
- Percentile: 96.0
- Lexical Diversity: 1.91892
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['13447243', '11596506', '13814820', '14095026', '14420754']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6982200197134556
- 35 USC 102 Novelty (BERT): 0.5151618432403513
- Combined Prediction Score: 0.6799142020661452
- Mean Citation Score: 184.977068
- Max Citation Score: 220.4356
- Similarity Product: 129.34114686455726

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test