PATENT CLAIM ANALYSIS

Application Number: 15879664
Application Type: Utility
Filing Date: 2018-01
Publication Date: 2018-06
Patent Classification: ["435", "007400"]

Abstract:
Disclosed are improved cell-permeable Parkin recombinant proteins (iCP-Parkin) which have been developed as a protein-based anti-neurodegenerative agent for efficient BBB-penetration to effectively deliver the recombinant protein into the brain. A Parkin protein, a dopaminergic neuronal cell death inhibitor, has been fused with a newly developed advanced macromolecule transduction domain (aMTD) and preferably with a solubilization domain (SD) to increase the solubility/yield and cell-/tissue-permeability of the recombinant protein. In addition, the aMTD/SD-fused recombinant iCP-Parkin protein has shown BBB-permeability. Both in vitro and in vivo, the iCP-Parkin recombinant protein improved motor skills, a typical phenotype of Parkinson's disease, by increasing dopamine level in the brain by suppressing apoptosis of dopaminergic neuron cells. It also can be applicable as a protein-based anti-neurodegenerative agent to treat Parkinson's disease by protecting dopaminergic neuron cells and regulating the secretion of dopamine.

Claim (Index 1):
A recombinant protein, which comprises a Parkin protein and an advanced macromolecule transduction domain (aMTD) being composed of 9\u02dc13 amino acid sequences and having improved cell or tissue permeability,\n wherein the aMTD is fused to one end or both ends of the Parkin protein and has the following features of: (a) being composed of 3 or more amino acids sequences selected from the group consisting of Ala, Val, Ile, Leu, and Pro; (b) having Proline at one or more of 7\u2032 and 8\u2032 positions, and 12\u2032 position of an amino acid sequence of the aMTD; and (c) having an instability index of 40-60; an aliphatic index of 180-220; and a grand average of hydropathy (GRAVY) of 2.1-2.6, as measured by Protparam.

Metadata:
- Claim Count in Document: 34.0
- Percentile: 86.0
- Lexical Diversity: 1.77011
- Patent Class: 435.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15432662', '15503117', '10622817', '14424762', '09785548']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.6584976366407703
- 35 USC 102 Novelty (BERT): 0.6391302728443525
- Combined Prediction Score: 0.6565609002611286
- Mean Citation Score: 423.1425860000001
- Max Citation Score: 726.3612
- Similarity Product: 536.3369146733522

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test