PATENT CLAIM ANALYSIS

Application Number: 16068559
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2019-01
Patent Classification: ["544", "331000"]

Abstract:
The present invention provides compounds of Formula (I) or a subgeneric structure or species thereof or a pharmaceutically acceptable salt, ester, solvate, and/or prodrug thereof and methods and compositions for treating or ameliorating abnormal cell proliferative disorders, such as cancer, wherein A, R 2 , R 3 , R 10 , E 1 , E 2 , E 3 , Y, and Z are as defined herein.

Claim (Index 96):
The compound of  claim 95 , wherein the compound has the structure of formula (XVIIB): or a stereoisomer or a pharmaceutically acceptable salt, solvate, ester, tautomer, or prodrug thereof; wherein:\n Z is CH or N; \n R 1  is selected from hydrogen, methyl, fluoro, chloro, bromo, CF 3 , or cyano; \n R 2  is \u2014OCF 3 , \u2014OCHF 2 , \u2014OCF 2 CF 3 , \u2014OCH 2 CHF 2 , \u2014OCH 2 CF 3 , cyclopropoxy, methoxy, \u2014OCD 3 , ethoxy, or isopropoxy; \n R 3  is N(R 10 )C 2-6  alkyl-NR 10 R 10 ; \n R 4a  and R 4b  are each independently H, halo, \u2014C 1-6  alkyl, or \u2014C 1-6  haloalkyl; \n R 4c  is cyano, \u2014C(\u2550O)NR 8 R 9  or \u2014NR 8 R 9 ; \n R 4N  is H, \u2014C 1-6  alkyl, or \u2014CD 3 ; \n R 8  and R 9  are independently H, \u2014CD 3 , C 1-6  alkyl, C 3-8  cycloalkyl, C 3 , cycloalkyl-(C 1-3  alkyl)-, C 1 -C 6  acyl, phenyl, monocyclic heteroaryl, or monocyclic heterocyclyl; and R 8  and R 9  may be further independently substituted with up to three substituents chosen from hydroxyl, C 1-6  alkoxy, oxo, thiono, cyano or halo; and \n each R 10  is independently H, \u2014CD 3 , or C 1-6  alkyl; or \n alternatively, two R 10  on the same N atom to which they are both attached, form a heterocyclic ring of 5-6 members, containing up to one other heteroatom selected from O, S, or NR 11 ; and \n each R 11  is independently hydrogen or C 1 -C 6  alkyl, which is optionally substituted with up to three substituents selected from hydroxyl, oxo, thiono, cyano and halo.

Metadata:
- Claim Count in Document: 70.0
- Percentile: 95.0
- Lexical Diversity: 1.5098
- Patent Class: 544.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13229178', '12008840', '12842389', '11282119', '12310150']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8095526429971985
- 35 USC 102 Novelty (BERT): 0.5175269534557349
- Combined Prediction Score: 0.7803500740430521
- Mean Citation Score: 314.529296
- Max Citation Score: 321.7707200000001
- Similarity Product: 237.42167445765503

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test