PATENT CLAIM ANALYSIS

Application Number: 15777333
Application Type: Utility
Filing Date: 2018-05
Publication Date: 2018-12
Patent Classification: ["514", "282000"]

Abstract:
The present invention provides a transdermal delivery device comprising a pharmaceutical composition, wherein said composition comprises a N-oxide derivative of an opioid antagonist, or a salt thereof, and an opioid agonist or salt thereof.

Claim (Index 28):
A pharmaceutical composition comprising:\n (i) a N-oxide derivative of an opioid antagonist of formula (I), or a salt thereof; (ii) an opioid agonist or salt thereof; and (iii) an adhesive and/or a matrix-forming polymer, wherein said compound of formula (I) is: wherein R 1  is selected from the group consisting of optionally substituted C 1-8  alkyl and optionally substituted C 2-8  alkenyl; R 2  is selected from the group consisting of OH, H, OC 1-8  alkyl, NHCOR, NR 1 COR, CONR 1 R and CONHR wherein R is a hydrocarbyl group or R 2  forms a bridge to the carbon to which R 3  is attached; R 3  is selected from O, CH 2 , N\u2014NH 2  or a linking group to a second N-oxide derivative of an opioid antagonist or a salt thereof when the dashed bond is present and is selected from OH, H, OC 1-8  alkyl, OCOR 1 , O(CH 2 CH 2 (CH 2 ) y O) x CH 3  wherein x is 1-10 and y is 0-3, N(R 1 ) 2 , NR 1 COR, NHCOR, CONR 1 R, CONHR, wherein R is a hydrocarbyl group, or a linking group to a second N-oxide derivative of an opioid antagonist or a salt thereof, when the dashed bond is absent and R 4  is selected from the group consisting of H, CONHR, CONR 1 R, NHCOR, NR 1 COR and C(OH)(R 1 ) 2 , wherein R is a hydrocarbyl group; or R 3  and R 4 , together with the carbon atoms to which they are attached form a heterocycle or a linking group to a second N-oxide derivative of an opioid antagonist or a salt thereof; R 5  is selected from the group consisting of OH, OC 1-8  alkyl, OCOR 1 , H and CONH 2 ; R 6  and R 7  are each independently selected from the group consisting of H, OH and OC 1-8  alkyl or R 6  and R 7 , together with the carbon atoms to which they are attached, form a dihydrofuran ring; and each dashed bond in the cyclohexyl ring may be present or absent with the proviso that both may not be present.

Metadata:
- Claim Count in Document: 8.0
- Percentile: 93.0
- Lexical Diversity: 1.40741
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15170201', '14585438', '12786686', '12176279', '13543022']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7345341668049693
- 35 USC 102 Novelty (BERT): 0.5042552386139468
- Combined Prediction Score: 0.7115062739858671
- Mean Citation Score: 254.688388
- Max Citation Score: 257.35855
- Similarity Product: 198.32257487332225

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test