PATENT CLAIM ANALYSIS

Application Number: 16026397
Application Type: Utility
Filing Date: 2018-07
Publication Date: 2018-11
Patent Classification: ["546", "323000"]

Abstract:
The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from such method of purification.

Claim (Index 4):
The compound of  claim 1 ; wherein PG is utilized for the reversible protection of a thiol functional group; and PG is selected from the group consisting of: wherein:\n the dashed line marked with an asterisk indicates attachment to T and the unmarked dashed line indicates attachment to the rest of the compound; \n Ar is an aromatic moiety which is optionally further substituted; \n R 01 , R 03 , and R 04  are independently of each other a chemical bond or is C 1-50  alkyl, C 2-50  alkenyl, or C 2-50  alkynyl, wherein:\n C 1-50  alkyl, C 2-50  alkenyl, and C 2-50  alkynyl are optionally substituted with one or more R 3 , which are the same or different; and \n C 1-50  alkyl, C 2-50  alkenyl, and C 2-50  alkynyl are optionally interrupted by one or more groups selected from the group consisting of -Q-, \u2014C(O)O\u2014, \u2014O\u2014, \u2014C(O)\u2014, \u2014C(O)N(R 4 )\u2014, \u2014S(O) 2 N(R 4 )\u2014, \u2014S(O)N(R 4 )\u2014, \u2014S(O) 2 \u2014, \u2014S(O)\u2014, \u2014N(R 4 )S(O) 2 N(R 4 ) \u2014, \u2014S\u2014, \u2014N(R 4 )\u2014, \u2014OC(O)R 4 , \u2014N(R 4 )C(O)\u2014, \u2014N(R 4 )S(O) 2 \u2014, \u2014N(R 4 )S(O)\u2014, \u2014N(R 4 )C(O)O\u2014, \u2014N(R 4 )C(O)N(R 4 )\u2014, and \u2014OC(O)N(R 4 R 4a ); \n \n R 02  is \u2014H, C 1-50  alkyl, C 2-50  alkenyl, or C 2-50  alkynyl, wherein:\n C 1-50  alkyl, C 2-50  alkenyl, and C 2-50  alkynyl are optionally substituted with one or more R 3 , which are the same or different; and \n C 1-50  alkyl, C 2-50  alkenyl, and C 2-50  alkynyl are optionally interrupted by one or more groups selected from the group consisting of -Q-, \u2014C(O)O\u2014, \u2014O\u2014, \u2014C(O)\u2014, \u2014C(O)N(R 4 )\u2014, \u2014S(O) 2 N(R 4 )\u2014, \u2014S(O)N(R 4 )\u2014, \u2014S(O)\u2014, \u2014S(O)\u2014, \u2014N(R 4 )S(O) 2 N 4a )\u2014, \u2014S\u2014, \u2014N(R 4 )\u2014, \u2014OC(O)R 4 , \u2014N(R 4 )C(O)\u2014, \u2014N(R 4 )S(O) 2 \u2014, \u2014N(R 4 )S(O)\u2014, \u2014N(R 4 )C(O)O\u2014, \u2014N(R 4 )C(O)N(R 4 )\u2014, and \u2014OC(O)N(R 4 R 4a ); \n \n Q is selected from the group consisting of phenyl, naphthyl, indenyl, indanyl, tetralinyl, C 3-10  cycloalkyl, 4-membered to 7-membered heterocyclyl, and 8 membered to 11-membered heterobicyclyl, wherein T is optionally substituted with one or more R 3 , which are the same or different;\n R 3  is halogen, \u2014CN, oxo (\u2550O), \u2014COOR 5 , \u2014OR 5 , \u2014C(O)R 5 , \u2014C(O)N(R 5 R 5a ), \u2014S(O) 2 N(R 5 R 5a ), \u2014S(O)N(R 5 R 5a ), \u2014S(O) 2 R 5 , S(O)R 5 , \u2014N(R 5 ) S(O) 2 N(R 5a R 5b ), \u2014SR 5 , \u2014N(R 5 R 5a ), \u2014NO 2 , \u2014OC(O)R 5 , \u2014N(R 5 )C(O)R 5a , \u2014N(R 5 )S(O) 2 R 5a , \u2014N(R 5 )S(O)R 5a , \u2014N(R 5 )C(O)OR 5a , \u2014N(R 5 )C(O)N(R 5a R 5b ), \u2014OC(O)N(R 5 R 5a ), or C 1-6  alkyl, wherein: \n C 1-6  alkyl is optionally substituted with one or more halogen, which are the same or different; and \n \n R 4 , R 4a , R 5 , R 5a , and R 5b  are independently selected from the group consisting of \u2014H or C 1-6  alkyl, wherein:\n C 1-6  alkyl is optionally substituted with one or more halogen, which are the same or different.

Metadata:
- Claim Count in Document: 50.0
- Percentile: 95.0
- Lexical Diversity: 1.17391
- Patent Class: 546.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['15027976', '14435350', '12990101', '14238437', '14650175']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8381229986361973
- 35 USC 102 Novelty (BERT): 0.5691920277974412
- Combined Prediction Score: 0.8112299015523218
- Mean Citation Score: 374.628792
- Max Citation Score: 520.1981
- Similarity Product: 364.767221950668

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test