PATENT CLAIM ANALYSIS

Application Number: 15888768
Application Type: Utility
Filing Date: 2018-02
Publication Date: 2018-06
Patent Classification: ["514", "044000"]

Abstract:
The present invention relates generally to immunostimulatory nucleic acids, compositions thereof and methods of using the immunostimulatory nucleic acids. In particular the invention relates to palindrome-containing immunostimulatory nucleic acids and the use of these nucleic acids in treating disease.

Claim (Index 1):
A P-Class immunostimulatory CpG oligonucleotide having the formula\n 5\u2032 X-P1-S-P2-T 3\u2032 \n wherein:\n X is a 5\u2032 TLR activation domain; \n P1 is a 5\u2032 palindromic region that is at least 6 nucleotides in length; \n P2 is a 3\u2032 palindromic region that is at least 8 nucleotides in length; \n S is a spacer disposed between P1 and P2 such that the palindromic regions do not overlap; and \n T is an optional 3\u2032 tail that is 0 or 1 nucleotide in length; further wherein: \n the oligonucleotide includes at least one pyrimidine-purine (YpR) dinucleotide; \n the oligonucleotide has the ability to spontaneously self-assemble under physiological conditions into a concatamer that consists of multiple copies of said oligonucleotide; and \n the oligonucleotide includes at least one stabilized internucleotide linkage selected from the group consisting of phosphorothioate, phosphorodithioate, methylphosphonate, and methylphosphorothioate.

Metadata:
- Claim Count in Document: 17.0
- Percentile: 88.0
- Lexical Diversity: 1.61538
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15165963', '14046044', '12600368', '12442295', '10978283']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8503366872706597
- 35 USC 102 Novelty (BERT): 0.5386781742273078
- Combined Prediction Score: 0.8191708359663246
- Mean Citation Score: 387.509962
- Max Citation Score: 402.00934
- Similarity Product: 276.51498334165814

Labels:
- Claim Label 101: 1
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 1
- Combined Label: 0
- Label 101 Adjusted: 1

Dataset: test