PATENT CLAIM ANALYSIS

Application Number: 15942321
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-10
Patent Classification: ["514", "210020"]

Abstract:
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Claim (Index 31):
The compound of  claim 30 , wherein said C 3-9  heteroaryl is: wherein each of R 14 , R 15 , and R 16  is independently selected from the group consisting of:\n a. branched or linear C 1-6  alkyl, wherein said alkyl can be optionally substituted with hydroxyl, halogen, \u2014CF 2 , \u2014CF 3 , amino, di(C 1-6 )alkylamino, mono(C 1-6 )alkylamino, cyano C 1-6  alkoxy, \u2014SO 2 R\u2032, \u2014SO 2 NR\u2032R\u2033, \u2014(CO)NR w R x , or \u2014NR w (CO)R x , wherein R w  and R x  are independently H or C 1-6  alkyl, or wherein two of R 14 , R 15 , and R 16 , as described herein, when attached to different atoms are taken together with the atom to which each is attached to form a bicyclic; \n b. C 3-7  cycloalkyl; \n c. C 3-7  heterocyclyl; \n d. hydroxyl; \n e. halogen; \n f. \u2014CF 2 ; \n g. \u2014CF 3 ; \n h. amino; \n i. di(C 1-6 )alkylamino; \n j. mono(C 1-6 )alkylamino; \n k. cyano; \n l. \u2014NR y (CO)R z , wherein R y  and R z  are independently H or C 1-6  alkyl; \n m. \u2014(CO)NR y R z , wherein R y  and R z  are independently H or C 1-6  alkyl; \n n. \u2014SO 2 NR y R z , wherein R y  and R z  are independently H or C 1-6  alkyl; and \n o. \u2014(CO)OR y , wherein R y  is H or C 1-6  alkyl; \n wherein two of the R 14 , R 15 , and R 16  attached to different atoms are taken together with the atom to which each is attached to form a bicyclic or tricyclic; wherein said bicyclic or tricyclic is optionally substituted.

Metadata:
- Claim Count in Document: 140.0
- Percentile: 90.0
- Lexical Diversity: 1.83333
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12530648', '13102720', '15281923', '13266976', '15852639']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.785048843813628
- 35 USC 102 Novelty (BERT): 0.511565238348669
- Combined Prediction Score: 0.7577004832671321
- Mean Citation Score: 269.39763800000003
- Max Citation Score: 276.27457000000004
- Similarity Product: 206.1162897259557

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test