PATENT CLAIM ANALYSIS

Application Number: 15945768
Application Type: Utility
Filing Date: 2018-04
Publication Date: 2018-10
Patent Classification: ["424", "186100"]

Abstract:
A synthetic, codon-optimized Hantaan virus (HTNV) full-length M gene open reading frame that consists of a unique nucleotide sequence encoding HTNV proteins. This synthetic gene was cloned into a plasmid to form the first optimized HTNV full-length M gene that elicits neutralizing antibodies in animals when delivered in combination with a similarly optimized Puumala virus (PUUV) DNA vaccine. The invention obviates the need for an extraneous gene sequence that was previously required for expression of the non-optimized HTNV gene. The synthetic gene is engineered into a molecular vaccine system to prevent hemorrhagic fever with renal syndrome (HFRS) caused by infection with HTNV, SEOV, or DOBV. Alternatively, it can be combined with the optimized PUUV DNA vaccine to protect against HFRS caused by any hantavirus.

Claim (Index 17):
An isolated nucleic acid sequence set forth in SEQ ID No. 2.

Metadata:
- Claim Count in Document: 2.0
- Percentile: 91.0
- Lexical Diversity: 1.63529
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['14756608', '15400028', '12449504', '13444828', '10394388']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8328000990525891
- 35 USC 102 Novelty (BERT): 0.686031679756129
- Combined Prediction Score: 0.8181232571229432
- Mean Citation Score: 687.648412
- Max Citation Score: 846.5879
- Similarity Product: 659.8300970650196

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test