PATENT CLAIM ANALYSIS

Application Number: 15941947
Application Type: Utility
Filing Date: 2018-03
Publication Date: 2018-11
Patent Classification: ["544", "367000"]

Abstract:
Compounds of the formula II: wherein     R 1  and R 2  are independently H, F or CH 3 ; or R 1  forms an ethynyl bond and R 2  is H or C 3 -C 6  cycloalkyl which is optionally substituted with one or two substituents independently selected from methyl, CF 3 , OMe or halo; R 3  is C 1 -C 3  alkyl or C 3 -C 6  cycloalkyl, either of which is optionally substituted with one or two methyl and/or a fluoro, trifluoromethyl or methoxy, when R 3  is C 3 -C 6  cycloalkyl it may alternatively be gem substituted with fluoro; R 4  is methyl or fluoro; m is 0, 1 or 2; E is a bond, or thiazolyl, optionally substituted with methyl or fluoro; A 1  is CH or N, A 2  is CR 6 R7 or NR 6 , provided at least one of A 1  and A 2  comprises N; R 6  is H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 1 -C 3  alkyl-O—C 1 -C 3  alkyl, or when A 2  is C, R 6  can also be C 1 -C 4  alkoxy or F; R 7  is H, C 1 -C 4  alkyl or F       or a pharmaceutically acceptable salt, N-oxide or hydrate thereof, have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.

Claim (Index 14):
A process of preparation of the compound according to  claim 13  comprising the step of reacting a compound of the formula with trifluoroacetic acid.

Metadata:
- Claim Count in Document: 26.0
- Percentile: 90.0
- Lexical Diversity: 2.65686
- Patent Class: 544.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['12739489', '14940817', '13831267', '13541519', '14249332']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8019988460854358
- 35 USC 102 Novelty (BERT): 0.5531311055963678
- Combined Prediction Score: 0.777112072036529
- Mean Citation Score: 449.06996
- Max Citation Score: 456.73325
- Similarity Product: 289.00598330459

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test