PATENT CLAIM ANALYSIS

Application Number: 15761995
Application Type: Utility
Filing Date: 2018-08
Publication Date: 2018-09
Patent Classification: ["514", "210180"]

Abstract:
Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

Claim (Index 159):
A compound selected from:\n (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-5-(oxetan-3-yloxy)-1H-benzo[d]imidazol-2-yl)-2-(trifluoromethyl)isonicotinamide A14; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-5-(oxetan-3-yloxy)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide A15; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-5-(oxetan-3-yloxy)-1H-benzo[d]imidazol-2-yl)-2-(difluoromethyl)isonicotinamide A16; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-5-((tetrahydro-2H-pyran-4-yl)oxy)-1H-benzo[d]imidazol-2-yl)-2-(trifluoromethyl)isonicotinamide A17; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-5-((tetrahydro-2H-pyran-4-yl)oxy)-1H-benzo[d]imidazol-2-yl)-2-(difluoromethyl)isonicotinamide A18; (S)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-5-((tetrahydro-2H-pyran-4-yl)oxy)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide A19; (R)\u2014N-(5-((1-acetylpiperidin-4-yl)oxy)-1-(1-acryloylazepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-(trifluoromethyl)isonicotinamide A20; (R)\u2014N-(5-((1-acetylpiperidin-4-yl)oxy)-1-(1-acryloylazepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-(difluoromethyl)isonicotinamide A21; (R)\u2014N-(5-((1-acetylpiperidin-4-yl)oxy)-1-(1-acryloylazepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide A22; (R)-1-(1-acryloylazepan-3-yl)-7-chloro-2-(2-methylisonicotinamido)-1H-benzo[d]imidazol-5-yl morpholine-4-carboxylate A23; (R)-1-(1-acryloylazepan-3-yl)-7-chloro-2-(2-methylisonicotinamido)-1H-benzo[d]imidazol-5-yl azetidine-1-carboxylate A24; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(oxetan-3-yloxy)-1H-benzo[d]imidazol-2-yl)-2-(trifluoromethyl)isonicotinamide C19; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(oxetan-3-yloxy)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide C20; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(oxetan-3-yloxy)-1H-benzo[d]imidazol-2-yl)-2-(difluoromethyl)isonicotinamide C21; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(oxetan-3-yloxy)-1H-benzo[d]imidazol-2-yl)imidazo[1,5-a]pyridine-7-carboxamide C22; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(oxetan-3-yloxy)-1H-benzo[d]imidazol-2-yl)imidazo[1,2-a]pyridine-7-carboxamide C23; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(oxetan-3-yloxy)-1H-benzo[d]imidazol-2-yl)-[1,2,4]triazolo[4,3-a]pyridine-7-carboxamide C24; (R)-1-(1-acryloylazepan-3-yl)-7-chloro-2-(2-methylisonicotinamido)-1H-benzo[d]imidazol-6-yl morpholine-4-carboxylate C25; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-((tetrahydro-2H-pyran-4-yl)oxy)-1H-benzo[d]imidazol-2-yl)-2-(trifluoromethyl)isonicotinamide D12; (R)\u2014N-(1-(1-acryloylazepan-3-yl)-7-(piperidin-4-yloxy)-1H-benzo[d]imidazol-2-yl)-2-(trifluoromethyl)isonicotinamide D13; and (R)\u2014N-(7-((1-acetylpiperidin-4-yl)oxy)-1-(1-acryloylazepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-(difluoromethyl)isonicotinamide D14; and single enantiomers, racemic mixtures, mixtures of diastereomers, and isotopic variants thereof; and pharmaceutically acceptable salts, solvates, and prodrugs thereof.

Metadata:
- Claim Count in Document: 86.0
- Percentile: 96.0
- Lexical Diversity: 2.025
- Patent Class: 514.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['15127000', '16005490', '14489231', '13431716', '13830712']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.8107196642225711
- 35 USC 102 Novelty (BERT): 0.5709480859725818
- Combined Prediction Score: 0.7867425063975721
- Mean Citation Score: 435.272624
- Max Citation Score: 474.12836
- Similarity Product: 348.0614084439087

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 1
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test