PATENT CLAIM ANALYSIS

Application Number: 16136058
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-01
Patent Classification: ["424", "139100"]

Abstract:
Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease. The peptide compositions contain constant domains from human IgG, camelid IgG, and/or shark IgNAR. The peptide compositions include heavy-chain only single-domain antibodies and compositions with one or more variable antigen binding domain bound to one or more constant domains.

Claim (Index 103):
The composition of  claim 97 , wherein the hinge region comprises an amino acid sequence at least 85% identical to amino acids 128-162 of SEQ ID NO: 11.

Metadata:
- Claim Count in Document: 7.0
- Percentile: 97.0
- Lexical Diversity: 1.76364
- Patent Class: 424.0
- Transitional Phrase Type: none
- Component Type: 0
- Foreign Priority: False
- Related Applications: ['13736852', '13917010', '15507676', '15638820', '10450036']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7197581134754548
- 35 USC 102 Novelty (BERT): 0.5986712347612143
- Combined Prediction Score: 0.7076494256040308
- Mean Citation Score: 367.465558
- Max Citation Score: 623.1730299999998
- Similarity Product: 401.0581078144024

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test