PATENT CLAIM ANALYSIS

Application Number: 16190869
Application Type: Utility
Filing Date: 2018-11
Publication Date: 2019-03
Patent Classification: ["514", "312000"]

Abstract:
The invention relates to administration of various pharmaceutical formulations of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, (cabozantinib) a c-Met inhibitor, and its metabolites, to achieve desirable pharmacokinetic and pharmacodynamic effects.

Claim (Index 6):
A method of treating cancer in a human patient, comprising orally administering to said patient a pharmaceutical formulation comprising a physiologically effective amount of cabozantinib at such a rate to achieve:\n a steady state area under the curve for cabozantinib (average AUC) of at least 35,000 ng\u00b7h/mL for a formulation comprising 100 mg of cabozantinib delivered once daily; an average maximum cabozantinib blood plasma concentration (average C max ) of at least 2400 ng/mL per each 100 mg dosage of cabozantinib delivered; an average minimum cabozantinib blood plasma concentration (average C max ) of at least 1100 ng/mL per each 100 mg dosage of cabozantinib delivered; and a ratio of AUC(cabozantinib) to the AUC of the sum of cabozantinib plus measured cabozantinib metabolites:\n AUC(Caboantinib)/AUC(Cabozantinib+Measured Metabolites) \n of at least 0.35;\n wherein the AUC is measured on day 22.

Metadata:
- Claim Count in Document: 15.0
- Percentile: 98.0
- Lexical Diversity: 1.28205
- Patent Class: 514.0
- Transitional Phrase Type: open
- Component Type: 1
- Foreign Priority: False
- Related Applications: ['15126767', '10706328', '14776337', '12845600', '13714246']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7344287043864542
- 35 USC 102 Novelty (BERT): 0.5936388173328431
- Combined Prediction Score: 0.7203497156810932
- Mean Citation Score: 328.67702799999995
- Max Citation Score: 562.41516
- Similarity Product: 402.53750948152543

Labels:
- Claim Label 101: 0
- Claim Label 102: 0
- Claim Label 103: 0
- Claim Label 112: 0
- Combined Label: 0
- Label 101 Adjusted: 0

Dataset: test