PATENT CLAIM ANALYSIS

Application Number: 16142907
Application Type: Utility
Filing Date: 2018-09
Publication Date: 2019-03
Patent Classification: ["514", "442000"]

Abstract:
The present invention relates to 1-[1-(benzoyl )-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives having pharmacological activity formula (I) to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of a cognitive disorder.

Claim (Index 24):
The method according to  claim 14 , wherein said compound is selected from the group consisting of:\n (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-fluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-phenylpyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-(methylthio)pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methylpyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-cyanopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S,4S)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-(trifluoromethyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-(tert-butoxy)pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-acetoxypyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S)-1-(4-acetoxy-3,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S)-1-(4-benzoyloxy-3,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S)-1-(3,4-dibenzyloxy-5-methoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S)-1-(3,4-dibenzoyloxy-5-methoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; (S)-1-((2S)-1-(3-acetoxy-4,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; and (S)-1-((2S)-1-(3-pivaloyloxy-4,5-dimethoxybenzoyl)-4,4-difluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile; or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof.

Metadata:
- Claim Count in Document: 56.0
- Percentile: 97.0
- Lexical Diversity: 1.225
- Patent Class: 514.0
- Transitional Phrase Type: closed
- Component Type: 1
- Foreign Priority: True
- Related Applications: ['14436715', '15776296', '12468632', '15738900', '10481543']

Analysis Scores:
- 35 USC 101 Eligibility (BERT): 0.7567101614530063
- 35 USC 102 Novelty (BERT): 0.6396024839927853
- Combined Prediction Score: 0.7449993937069842
- Mean Citation Score: 310.28643
- Max Citation Score: 611.5246
- Similarity Product: 548.8403629518747

Labels:
- Claim Label 101: 1
- Claim Label 102: 1
- Claim Label 103: 1
- Claim Label 112: 0
- Combined Label: 1
- Label 101 Adjusted: 1

Dataset: test