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All are true about Cancer breast, except:
Affected sibling is a risk factor
Paget's disease of nipple is intraductal type of CA
Common in aged nulliparous
Increased incidence with prolonged breast feeding
3
1
National program for prevention and control of Cancer, Diabetes, Cardiovascular disease and stroke (NPCDCS), true is -
Separate centre for stroke, DM, cancer
Implementation in some 5 states over 10 districts
District hospital has specialised facilities
Subcentre has facility for diagnosis and treatment
2
2
Hereditary non-polyposis colorectal cancer (HNPCC) has an increased risk of all the following except
Endometrium
Ovary
Stomach
Pancreas
3
3
All the following are the risk factors for cervical cancer except
Young age at first intercourse
Multiple sexual paners
Low parity
Low socioeconomic status
2
4
50 year old male with positive family history of prostate cancer has come to you for a screening test. The screening test done to pickup prostate cancer is
DRE
PSA
DRE + PSA
Endorectal coil MRI with T1 and T2 W images
2
5
A patient with cervix cancer is missed by a screening test and later diagnosed with advanced disease. This time interval is called ?
Lead time
Screening time
Serial interval
Generation time
0
6
Mrs Shikha, 50-years-old woman is diagnosed with cervical cancer. Which lymph node group would be the first involved in metastatic spread of this disease beyond the cervix and uterus? NOT RELATED -anatomy
Common iliac nodes
Parametrial nodes
External iliac node
Paracervical or ureteral nodes
3
7
Drug used in cancer chemotherapy induced vomiting is?
Aprepitant
Dexamethasone
Ondansetrin
All of the above
3
8
Anticoagulant of choice for prophylaxis of venous thromboembolism in patient with cancer surgery is:-
Heparin sulfate
Protamine sulfate
Low molecular weight heparin
Warfarin
2
9
Hypercalcemia is most commonly associated in which of the following cancers?
Renal cell cancer
Carcinoma stomach
Squamous cell carcinoma of lung
Hepatocellular carcinoma
2
10
A female undergone surgery for left breast cancer 3 yrs back now developed blue nodule on same side
Lymphangiosarcoma
Recurrence
Hemangioma
Cellulitis
0
11
16 yr unmarried girl came for vaccination against cervical cancer. Which vaccine to he given:
Gardasil
Rabivac
Biovac
Tvac
0
12
Which of the following anti–cancer drug is NOT 'S'–phase specific ?
Methotrexate
Mercaptopurine
Ifosfamide
Thioguanine
2
13
Krukenberg tumor is associated mostly with which cancer?
Stomach
Breast
Liver
Pancreas
0
14
Which cancer is most commonly associated with increased estrogen levels?
Cervix
Ovarian
Breast
GTN
2
15
The dose of radiation for point A for early and locally advancing cervical cancer during brachytherapy according to ABS guidelines is:
70-75Gy- 75-80Gy
75-75Gy- 80-85Gy
80-85Gy- 85-90Gy
85-90Gy- 90-95Gy
2
16
Most common radiation induced cancer:
Thyroid Carcinoma
Breast Carcinoma
Leukemia
Sarcomas
2
17
30 out of 50 smokers and 10 out of 50 non smokers develop lung cancer. What is odd's Ratio
4
2.8
6
7
2
18
A 70 year old male chronic smoker is diagnosed of having cancer of the urinary bladder. It is confined to the trigone and extention is upto the submucosa. The management would be -
Complete Transurethral resction
Complete Transurethral resection with intravesical chemotherapy
Palliative Radiotherapy
Radical Cystectomy
1
19
Ten days after an exploratory laparotomy and lysis of adhesions, a patient, who previously underwent a low anterior resection for rectal cancer followed by postoperative chemoradiation, is noted to have succus draining from the wound. She appears to have adequate source control--she is afebrile with a normal white blood count. The output from the fistula is approximately 150 cc per day. Which of the following factors is most likely to prevent closure of the enterocutaneous fistula?
Previous radiation
Previous chemotherapy
Recent surgery
History of malignancy
0
20
The first step when doing a pneumonectomy for cancer of the bronchus is to:
Ligate the pulmonary vein
Ligate pulmonary aery
Divide the bronchus
Perform lymph node clearance
1
21
Which of the following anticancer drug can cause flagellated dermatitis?
Cisplatin
L-asparginase
Doxorubicin
Bleomycin
3
22
In stage III ovarian cancer patient with upper abdominal disease < 5cm, management of choice is
Debulking surgery
Mantle cell irradiation
Abdomino-pelvic radiotherapy
Neo-adjuvant chemotherapy
0
23
The commonest cancer of oral cavity is
Adenocarcinoma
Melanoma
Sarcoma
Squaous cell carcinoma
3
24
Radiation induced thyroid cancer is -
Papillary
Follicular
Anaplastic
Medullary
0
25
The most common histologic type of thyroid cancer is -
Medullary type
Follicular type
Papillary type
Anaplastic type
2
26
Which type of Human papilloma virus is most commonly associated with Cervical cancer ?
HPV 16
HPV 24
HPV 32
HPV 36
0
27
Osteosclerotic metastasis is common in cancer of:
Prostate
Lungs
Malignant melanoma
Renal cell carcinoma
0
28
Hypercalcemia is seen in which cancer
RCC
Carcinoma stomach
Small cell carcinoma lung
Hepatocellular carcinoma
0
29
The following is not one of the 4 key cell cycle regulators which are dysregulated in a variety of human cancers
P16/INK4a
Cyclin D
P21
RB
2
30
About the treatment of esophageal cancer, false statement is:
5% of patients survive 5 years after the diagnosis
The efficacy of primary radiation therapy for squamous cell carcinomas is similar to that of radical surgery
Surgical resection of all gross tumor is feasible in only 45% of cases
Chemotherapy is highly effective and sometimes curable
3
31
Monoclonal antibody used in Head and neck cancer is:-
Pembrolizumab
Trastuzumab
Rituximab
Ocralizumab
0
32
The most common histologic type of thyroid cancer is
Medullary type
Follicular type
Papillary type
Anaplastic type
2
33
High-risk breast cancer female investigation of choice is?
MRI
USG
Mammography
Clinical examination
0
34
Gene associated with autosomal dominant breast cancer?
PTEN and KAI
BRCA 1 and 2
APC
P53
1
35
8000 rads dosage in Cancer cervix is given to -
Point A
Point B
Side walls of pelvis
None of the above
0
36
Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis
Cyclophosphamide
Busulfan
Procarbazine
Mesna
0
37
Precancerous lesion of gall bladder is
Porcelain gall bladder
Mirrizi syndrome
Cholesterosis
Acalculous Cholecystitis
0
38
In cancer colon investigation of choice is:
CT scan
Barium enema
Colonoscopy
X-ray
2
39
Use of oral contraceptives increases the risk of which cancer -
Colon
Ovary
Breast
All of the above
2
40
Which of the following is the most common cancer of thyroid
Anaplastic carcinoma
Follicular carcinoma
Papillary carcinoma
Medullary carcinoma
2
41
M/C ovarian cancer associated with endometriosis:
Endometroid tumor
Clear cell tumor
Germ cell tumor
Brenner tumor
1
42
Antifungal used as cancer chemotherapeutic agent is :
Flucytosine
Nystatin
Voriconazole
Terbinafine
0
43
True about tongue cancer:
Most common type is adenocarcinoma
Cervical lymph node metastasis is universally present
MC site is on Lateral margin
Slurring of speech is a common complaint
2
44
A 69 year old male presents with an episode of slurring of speech which lasted for 12 hours and then resolved.He is heavy smoker having smoked 60 cigarettes per day for 40 years. He had a single episode of haemoptysis 4 weeks previously and has underlying lung cancer with brain metastases and is referred for an urgent CT chest. An ECG was performed which showed new AF. All blood tests including cardiac biomarkers were normal. Chest CT is shown. Which of the following is most probable diagnosis?
Left atrial myxoma
Left atrial thrombus
Infective endocarditis
Rhabdomyoma
1
45
A pateint with cervix cancer is mised by a screeing test and later diagnosed with advanced disease. This time interval is called
Lead time
Screening time
Serial interval
Generation time
0
46
Which of the following anticancer drug can result in "disulfiram reaction"
Lomustine
L-Asparginase
Procarbazine
Busulfan
2
47
Several weeks after surgical dissection of her left axilla for the removal of lymph nodes for staging and treatment of her breast cancer, a 32-year-old woman was told by her general physician that she had "winging" of her left scapula when she pushed against resistance during her physical examination. She told the physician that she had also experienced difficulty lately in raising her right arm above her head when she was combing her hair. In a subsequent consult visit with her surgeon, she was told that a nerve was accidentally injured during the diagnostic surgical procedure and that this produced her scapular abnormality and inability to raise her arm normally. What was the origin of this nerve?
The upper trunk of her brachial plexus
The posterior division of the middle trunk
Roots of the brachial plexus
The posterior cord of the brachial plexus
2
48
In exocrine pancreatic cancer, the commonest tumour marker to be elevated as -
CA-125
CEA
CA-15-3
CA-19-9
3
49
Preferred method of contraception for a female with family H/O ovarian cancer :
POP
Cu IUCD
OCP
Barrier method
2
50
Which of the following is a precancerous condition of cancer stomach?
Peptic ulcer
Chronic gastric atrophy
Achalasia cardia
Curling's Ulcer
1
51
All of the following anticancer drugs are cell cycle non-specific except?
Cisplatin
Vincristine
Mitomycin-C
Cyclophosphamide
1
52
All of the following are hormonal agents used against breast cancer except -
Latrazole
Exemestane
Taxol
Tamoxifen
2
53
A 70-year-old man has smoked for years despite a chronic productive cough. One day, he notices blood in his sputum and goes to see his physician. A chest x-ray reveals a mass in the left lung, which is biopsied during a fiberoptic bronchoscopy. Assuming that this patient's cancer is etiologically related to his smoking, which of the following diagnoses are most likely to be returned by the pathology laboratory?
Adenocarcinoma or bronchioloalveolar carcinoma
Adenocarcinoma or small cell carcinoma
Bronchioloalveolar carcinoma or small cell carcinoma
Small cell carcinoma or squamous cell carcinoma
3
54
Which enzymatic mutation is responsible for immortality of cancer cells?
DNA reverse transcriptase
RNA polymerase
Telomerase
DNA polymerase
2
55
Strong correlation with colorectal cancer is seen in
Peutz-Jegher's polyp
Familial polyposis coli
Juvenile polyposis
Hyperplastic polyp
1
56
Which of the following is the investigation of choice for assessment of depth of penetration and perirectal node involvement in rectal cancer?
MRI scan
CT scan pelvis
Double contrast barium enema
Transrectal ultrasound
0
57
Patient because of positive biopsy findings and negative workup undergoes a radical prostatectomy. The pathology repo reveals Gleason score 9/10 and involvement of several pelvic lymph nodes. Which is the most likely site for prostatic cancer metastasis?
Liver
Kidney
Lung
Bone
3
58
The following anticancer drug has high emetogenic potential
Chlorambucil
Vincristine
6-Mercaptopurine
Cisplatin
3
59
The following condition of GB is precancerous -
Cholesterosis
Porcelain gall bladder
Biliary atresia
Choledochal cyst
1
60
Which of the following is a metastasis suppressor gene in relation to prostate cancer
KAI - 1
NM 23
KISS
p53
0
61
The following condition of GB is precancerous
Cholesterosis
Porcelain gall bladder
Biliary atresia
Choledochal cyst
1
62
Smoking is a risk factor for all cancer except:
Esophagus
Urinary bladder
Pancreas
Gallbladder
3
63
Which of the following anticancer drugs acts by hypomethylation?
Gemcitabine
5-FU
Decitabine
Homoharringotonine
2
64
First symptom in vulval cancer is-
Pain
Pruritus
Ulceration
Bloody discharge
1
65
A 58 year old male presents with hematuria. He s diagnosed of having bladder cancer which extends muscle deep. The best treatment is
Intravesical Chemotherapy
Neoadjuvant chemotherapy followed by radical cystectomy
Radiotherapy
Tranurethral resection
1
66
A 56-year-old woman with a history of breast cancer that was treated 5 years ago with lumpectomy and radiation but with no chemotherapy returns with bone pain, fatigue, and weakness. A complete blood count reveals severe anemia, as well as decreased white blood cells and platelets. Examination of a peripheral blood smear reveals small numbers of nucleated red cells, as well as an occasional "blast" cell and myelocyte. A likely cause of the hematologic abnormalities is
chloramphenicol.
Diphyllobothrium latum infestation.
megaloblastic anemia.
myelophthisic anemia.
3
67
All the following are hormonal agents used against breast cancer EXCEPT :
Letrozole
Exemestane
Taxol
Tamoxifen
2
68
Which group of anticancer drugs temozolomide belong to :
Oral alkylating agent
Antitumor Antibiotic
Antimetabolite
Mitotic Spindle Inhibitor
0
69
According to AJCC 8th edition, staging of 2 cm size pancreatic cancer if it involves poal vein in:
T1
T2
T3
T4
0
70
Nanotechnology has found tremendous application in the diagnosis of cancers because of all of following advantages, except
Nanocrystals exibit bright, photostable fluorescence
Nonocrystals have a narrow spectrum wavelength
Peak spectrum wavelength is tunable
Nanocrystals exhibit a narrow difference between their excitation and emission peak spectra
3
71
A 30 year old female presented with unilateral breast cancer associated with axillary lymph node enlargement. Modified radical mastectomy was done, fuher treatment plan will be:
Observation and follow up
Adriamycin based chemotherapy followed by tamoxifen depending on estrogen/progesterone receptor status
Adriamycin based chemotherapy only
Tamoxifen only
1
72
Most common histological subtype of cancer endometrium is :
Mucinous carcinoma
Clear cell carcinoma
Squamous cell carcinoma
Endometrioid adenocarcinoma
3
73
Most common lung cancers in non smokers is
Squamous cell carcinoma
Bronchoalveolar carcinoma
Small cell carcinoma
Adenocarcinoma
3
74
Which of the following is FALSE regarding breast cancer during pregnancy?
Axillary lymph node metastases in 75% of affected women
Mammography is sensitivity during pregnancy
Radiation cannot be considered for treatment
Less than 25% of the breast nodules are cancerous
1
75
A patient with oral cancer, had ipsilateral lymph node measuring 2 cm, single in number with capsular spread. According to TNM staging it is included under:
Nx
N1
N2
N3
3
76
Cell cycle specific anti-cancerous drug is?
Cyclophosphamide
Vincristine
Nitrogen mustard
Doxorubicin.
1
77
Commonest cancer in burn scar is -
Sq. cell Ca
Fibrosarcoma
Adenoa Ca
Adeno-squamous Ca
0
78
The postoperative quality of life (QOL) scores of 200 prostate cancer patients have a mean of 60 and a standard detion of 10. How many patients are expected to have a QOL score between 40 and 80?
190
136
120
140
0
79
Which one of the following is the most sensitive and specific screening test to detect breast cancer?
Regular X-ray
Self breast examination
Mammography
Regular biopsy
2
80
Origin of cancer cells in Krukenberg tumour is from: March 2013
Ovarian carcinoma
Gastric carcinoma
Duodenal carcinoma
Pancreatic carcinoma
1
81
Pseudomyxoma peritonii is seen in which ovarian cancer?
Serous cystadenocarcinoma
Mucinous cystadenocarcinoma
Brenner Tumor
Fibroma
1
82
EBV is associated with which type of cancer?
Nasopharyngeal carcinoma
Epidermodysplasia
Kaposi sarcoma
null
0
83
Cadmium can cause all cancer except-
Lung
Pancreas
Prostate
Skin
3
84
Most common type of HPV associated with cervical cancer ?
6, 11
5, 8
16, 18
6, 8
2
85
Which of the following pathologic findings is/are the strongest contraindication to breast preservation (lumpectomy with breast radiation) as primary treatment for a newly diagnosed breast cancer?
Grade 3, poorly differentiated, infiltrating ductal carcinoma
Extensive intraductal cancer around the invasive lesion
Tumor size less than 3 cm
Positive surgical margin for invasive cancer
3
86
If a 95% confidence interval for prevalence of cancer smokers aged> 65 years is 56% to 76%, the chance that the prevalence could be less than 56% is-
Nil
44%
2.50%
5%
2
87
Which of the following is a triple negative breast cancer -
Colloid Cancer
Secretory cell cancer
Acinic Cell Carcinoma
Mucinous Carcinoma
1
88
Example for radiation induced cancer is:
Papillary carcinoma thyroid
Follicular carcinoma thyroid
Lymphoma
Hepatoma
0
89
A 70-year-old woman with a history of ovarian cancer presents with diarrhea. She completed radiation therapy for her cancer 3 months ago. Physical examination shows cachexia, hyperactive bowel sounds, and generalized pallor. The stools are found to contain blood. A CBC shows decreased hemoglobin (7.8 g/dL) and decreased mean corpuscular volume (70 mm3). Which of the following is the most likely cause of GI bleeding in this patient?
Angiodysplasia
Hemorrhoids
Ischemic colitis
Radiation enterocolitis
3
90
Arrange the following causes of NCD deaths as per decreasing order of frequency? A. Cancers B. Cardiovascular diseases C. Diabetes D. Respiratory diseases
A>D>C>B
D>A>B>C
B>A>D>C
C>B>D>A
2
91
Virus causing cervical cancer in the ectocervix -
HPV16
HPV17
HPV11
HPV19
0
92
Which of the following strategy has been recommended to reduce the heredity risk for ovarian cancer in women with BRCA -1 and BRCA - 2 mutations :
Use of oral contraceptive pills
Screening with transvaginal ultrasound
Screening with CA - 125
Prophylactic oophorectomy
3
93
Precancerous lesion of bone among the following is
Paget disease
Chronic osteomyelitis
Benign giant cell tumor
All of the above
3
94
Cancer management in which of following malignancies has dramatically increased the survival?
Esophagus carcinoma
Glioblastoma multiforme
ALL in children
Cholangiocarcinoma
2
95
Example for radiation induced cancer is ?
Papillary carcinoma thyroid
Follicular carcinoma thyroid
Lymphoma
Hepatoma
0
96
Smoking predisposes to all of the following cancers except -
Carcinoma larynx
Carcinoma bladder
Carcinoma stomach
Lymphoma
3
97
A 70-year-old male Rohan with advanced visceral cancer dies of extensive myocardial infarction. Autopsy also reveals sterile non-destructive vegetations along the mitral leaflet edges. The pathogenesis of this patient's vegetations is most similar to that of:
Hypercalcemia of malignancy
Distant metastases
Trousseau syndrome
Raynaud's phenomenon
2
98
A patient with cancer developed extreme degree of radiation toxicity. Further history revealed that the dose adjustment of a particular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment during radiotherapy in order to prevent radiation toxicity?
Vincristine
Dactinomycin
Cyclophosphamide
6- Mercaptopurine
1
99
Anticancer drug causing nephrotoxicity: September 2009
Imitanib
Irinotecan
fosfestrol
Cisplatin
3
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