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0 | All are true about Cancer breast, except: | Affected sibling is a risk factor | Paget's disease of nipple is intraductal type of CA | Common in aged nulliparous | Increased incidence with prolonged breast feeding | 3 |
1 | National program for prevention and control of Cancer, Diabetes, Cardiovascular disease and stroke (NPCDCS), true is - | Separate centre for stroke, DM, cancer | Implementation in some 5 states over 10 districts | District hospital has specialised facilities | Subcentre has facility for diagnosis and treatment | 2 |
2 | Hereditary non-polyposis colorectal cancer (HNPCC) has an increased risk of all the following except | Endometrium | Ovary | Stomach | Pancreas | 3 |
3 | All the following are the risk factors for cervical cancer except | Young age at first intercourse | Multiple sexual paners | Low parity | Low socioeconomic status | 2 |
4 | 50 year old male with positive family history of prostate cancer has come to you for a screening test. The screening test done to pickup prostate cancer is | DRE | PSA | DRE + PSA | Endorectal coil MRI with T1 and T2 W images | 2 |
5 | A patient with cervix cancer is missed by a screening test and later diagnosed with advanced disease. This time interval is called ? | Lead time | Screening time | Serial interval | Generation time | 0 |
6 | Mrs Shikha, 50-years-old woman is diagnosed with cervical cancer. Which lymph node group would be the first involved in metastatic spread of this disease beyond the cervix and uterus? NOT RELATED -anatomy | Common iliac nodes | Parametrial nodes | External iliac node | Paracervical or ureteral nodes | 3 |
7 | Drug used in cancer chemotherapy induced vomiting is? | Aprepitant | Dexamethasone | Ondansetrin | All of the above | 3 |
8 | Anticoagulant of choice for prophylaxis of venous thromboembolism in patient with cancer surgery is:- | Heparin sulfate | Protamine sulfate | Low molecular weight heparin | Warfarin | 2 |
9 | Hypercalcemia is most commonly associated in which of the following cancers? | Renal cell cancer | Carcinoma stomach | Squamous cell carcinoma of lung | Hepatocellular carcinoma | 2 |
10 | A female undergone surgery for left breast cancer 3 yrs back now developed blue nodule on same side | Lymphangiosarcoma | Recurrence | Hemangioma | Cellulitis | 0 |
11 | 16 yr unmarried girl came for vaccination against cervical cancer. Which vaccine to he given: | Gardasil | Rabivac | Biovac | Tvac | 0 |
12 | Which of the following anti–cancer drug is NOT 'S'–phase specific ? | Methotrexate | Mercaptopurine | Ifosfamide | Thioguanine | 2 |
13 | Krukenberg tumor is associated mostly with which cancer? | Stomach | Breast | Liver | Pancreas | 0 |
14 | Which cancer is most commonly associated with increased estrogen levels? | Cervix | Ovarian | Breast | GTN | 2 |
15 | The dose of radiation for point A for early and locally advancing cervical cancer during brachytherapy according to ABS guidelines is: | 70-75Gy- 75-80Gy | 75-75Gy- 80-85Gy | 80-85Gy- 85-90Gy | 85-90Gy- 90-95Gy | 2 |
16 | Most common radiation induced cancer: | Thyroid Carcinoma | Breast Carcinoma | Leukemia | Sarcomas | 2 |
17 | 30 out of 50 smokers and 10 out of 50 non smokers develop lung cancer. What is odd's Ratio | 4 | 2.8 | 6 | 7 | 2 |
18 | A 70 year old male chronic smoker is diagnosed of having cancer of the urinary bladder. It is confined to the trigone and extention is upto the submucosa. The management would be - | Complete Transurethral resction | Complete Transurethral resection with intravesical chemotherapy | Palliative Radiotherapy | Radical Cystectomy | 1 |
19 | Ten days after an exploratory laparotomy and lysis of adhesions, a patient, who previously underwent a low anterior resection for rectal cancer followed by postoperative chemoradiation, is noted to have succus draining from the wound. She appears to have adequate source control--she is afebrile with a normal white blood count. The output from the fistula is approximately 150 cc per day. Which of the following factors is most likely to prevent closure of the enterocutaneous fistula? | Previous radiation | Previous chemotherapy | Recent surgery | History of malignancy | 0 |
20 | The first step when doing a pneumonectomy for cancer of the bronchus is to: | Ligate the pulmonary vein | Ligate pulmonary aery | Divide the bronchus | Perform lymph node clearance | 1 |
21 | Which of the following anticancer drug can cause flagellated dermatitis? | Cisplatin | L-asparginase | Doxorubicin | Bleomycin | 3 |
22 | In stage III ovarian cancer patient with upper abdominal disease < 5cm, management of choice is | Debulking surgery | Mantle cell irradiation | Abdomino-pelvic radiotherapy | Neo-adjuvant chemotherapy | 0 |
23 | The commonest cancer of oral cavity is | Adenocarcinoma | Melanoma | Sarcoma | Squaous cell carcinoma | 3 |
24 | Radiation induced thyroid cancer is - | Papillary | Follicular | Anaplastic | Medullary | 0 |
25 | The most common histologic type of thyroid cancer is - | Medullary type | Follicular type | Papillary type | Anaplastic type | 2 |
26 | Which type of Human papilloma virus is most commonly associated with Cervical cancer ? | HPV 16 | HPV 24 | HPV 32 | HPV 36 | 0 |
27 | Osteosclerotic metastasis is common in cancer of: | Prostate | Lungs | Malignant melanoma | Renal cell carcinoma | 0 |
28 | Hypercalcemia is seen in which cancer | RCC | Carcinoma stomach | Small cell carcinoma lung | Hepatocellular carcinoma | 0 |
29 | The following is not one of the 4 key cell cycle regulators which are dysregulated in a variety of human cancers | P16/INK4a | Cyclin D | P21 | RB | 2 |
30 | About the treatment of esophageal cancer, false statement is: | 5% of patients survive 5 years after the diagnosis | The efficacy of primary radiation therapy for squamous cell carcinomas is similar to that of radical surgery | Surgical resection of all gross tumor is feasible in only 45% of cases | Chemotherapy is highly effective and sometimes curable | 3 |
31 | Monoclonal antibody used in Head and neck cancer is:- | Pembrolizumab | Trastuzumab | Rituximab | Ocralizumab | 0 |
32 | The most common histologic type of thyroid cancer is | Medullary type | Follicular type | Papillary type | Anaplastic type | 2 |
33 | High-risk breast cancer female investigation of choice is? | MRI | USG | Mammography | Clinical examination | 0 |
34 | Gene associated with autosomal dominant breast cancer? | PTEN and KAI | BRCA 1 and 2 | APC | P53 | 1 |
35 | 8000 rads dosage in Cancer cervix is given to - | Point A | Point B | Side walls of pelvis | None of the above | 0 |
36 | Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis | Cyclophosphamide | Busulfan | Procarbazine | Mesna | 0 |
37 | Precancerous lesion of gall bladder is | Porcelain gall bladder | Mirrizi syndrome | Cholesterosis | Acalculous Cholecystitis | 0 |
38 | In cancer colon investigation of choice is: | CT scan | Barium enema | Colonoscopy | X-ray | 2 |
39 | Use of oral contraceptives increases the risk of which cancer - | Colon | Ovary | Breast | All of the above | 2 |
40 | Which of the following is the most common cancer of thyroid | Anaplastic carcinoma | Follicular carcinoma | Papillary carcinoma | Medullary carcinoma | 2 |
41 | M/C ovarian cancer associated with endometriosis: | Endometroid tumor | Clear cell tumor | Germ cell tumor | Brenner tumor | 1 |
42 | Antifungal used as cancer chemotherapeutic agent is : | Flucytosine | Nystatin | Voriconazole | Terbinafine | 0 |
43 | True about tongue cancer: | Most common type is adenocarcinoma | Cervical lymph node metastasis is universally present | MC site is on Lateral margin | Slurring of speech is a common complaint | 2 |
44 | A 69 year old male presents with an episode of slurring of speech which lasted for 12 hours and then resolved.He is heavy smoker having smoked 60 cigarettes per day for 40 years. He had a single episode of haemoptysis 4 weeks previously and has underlying lung cancer with brain metastases and is referred for an urgent CT chest. An ECG was performed which showed new AF. All blood tests including cardiac biomarkers were normal. Chest CT is shown. Which of the following is most probable diagnosis? | Left atrial myxoma | Left atrial thrombus | Infective endocarditis | Rhabdomyoma | 1 |
45 | A pateint with cervix cancer is mised by a screeing test and later diagnosed with advanced disease. This time interval is called | Lead time | Screening time | Serial interval | Generation time | 0 |
46 | Which of the following anticancer drug can result in "disulfiram reaction" | Lomustine | L-Asparginase | Procarbazine | Busulfan | 2 |
47 | Several weeks after surgical dissection of her left axilla for the removal of lymph nodes for staging and treatment of her breast cancer, a 32-year-old woman was told by her general physician that she had "winging" of her left scapula when she pushed against resistance during her physical examination. She told the physician that she had also experienced difficulty lately in raising her right arm above her head when she was combing her hair. In a subsequent consult visit with her surgeon, she was told that a nerve was accidentally injured during the diagnostic surgical procedure and that this produced her scapular abnormality and inability to raise her arm normally. What was the origin of this nerve? | The upper trunk of her brachial plexus | The posterior division of the middle trunk | Roots of the brachial plexus | The posterior cord of the brachial plexus | 2 |
48 | In exocrine pancreatic cancer, the commonest tumour marker to be elevated as - | CA-125 | CEA | CA-15-3 | CA-19-9 | 3 |
49 | Preferred method of contraception for a female with family H/O ovarian cancer : | POP | Cu IUCD | OCP | Barrier method | 2 |
50 | Which of the following is a precancerous condition of cancer stomach? | Peptic ulcer | Chronic gastric atrophy | Achalasia cardia | Curling's Ulcer | 1 |
51 | All of the following anticancer drugs are cell cycle non-specific except? | Cisplatin | Vincristine | Mitomycin-C | Cyclophosphamide | 1 |
52 | All of the following are hormonal agents used against breast cancer except - | Latrazole | Exemestane | Taxol | Tamoxifen | 2 |
53 | A 70-year-old man has smoked for years despite a chronic productive cough. One day, he notices blood in his sputum and goes to see his physician. A chest x-ray reveals a mass in the left lung, which is biopsied during a fiberoptic bronchoscopy. Assuming that this patient's cancer is etiologically related to his smoking, which of the following diagnoses are most likely to be returned by the pathology laboratory? | Adenocarcinoma or bronchioloalveolar carcinoma | Adenocarcinoma or small cell carcinoma | Bronchioloalveolar carcinoma or small cell carcinoma | Small cell carcinoma or squamous cell carcinoma | 3 |
54 | Which enzymatic mutation is responsible for immortality of cancer cells? | DNA reverse transcriptase | RNA polymerase | Telomerase | DNA polymerase | 2 |
55 | Strong correlation with colorectal cancer is seen in | Peutz-Jegher's polyp | Familial polyposis coli | Juvenile polyposis | Hyperplastic polyp | 1 |
56 | Which of the following is the investigation of choice for assessment of depth of penetration and perirectal node involvement in rectal cancer? | MRI scan | CT scan pelvis | Double contrast barium enema | Transrectal ultrasound | 0 |
57 | Patient because of positive biopsy findings and negative workup undergoes a radical prostatectomy. The pathology repo reveals Gleason score 9/10 and involvement of several pelvic lymph nodes. Which is the most likely site for prostatic cancer metastasis? | Liver | Kidney | Lung | Bone | 3 |
58 | The following anticancer drug has high emetogenic potential | Chlorambucil | Vincristine | 6-Mercaptopurine | Cisplatin | 3 |
59 | The following condition of GB is precancerous - | Cholesterosis | Porcelain gall bladder | Biliary atresia | Choledochal cyst | 1 |
60 | Which of the following is a metastasis suppressor gene in relation to prostate cancer | KAI - 1 | NM 23 | KISS | p53 | 0 |
61 | The following condition of GB is precancerous | Cholesterosis | Porcelain gall bladder | Biliary atresia | Choledochal cyst | 1 |
62 | Smoking is a risk factor for all cancer except: | Esophagus | Urinary bladder | Pancreas | Gallbladder | 3 |
63 | Which of the following anticancer drugs acts by hypomethylation? | Gemcitabine | 5-FU | Decitabine | Homoharringotonine | 2 |
64 | First symptom in vulval cancer is- | Pain | Pruritus | Ulceration | Bloody discharge | 1 |
65 | A 58 year old male presents with hematuria. He s diagnosed of having bladder cancer which extends muscle deep. The best treatment is | Intravesical Chemotherapy | Neoadjuvant chemotherapy followed by radical cystectomy | Radiotherapy | Tranurethral resection | 1 |
66 | A 56-year-old woman with a history of breast cancer that was treated 5 years ago with lumpectomy and radiation but with no chemotherapy returns with bone pain, fatigue, and weakness. A complete blood count reveals severe anemia, as well as decreased white blood cells and platelets. Examination of a peripheral blood smear reveals small numbers of nucleated red cells, as well as an occasional "blast" cell and myelocyte. A likely cause of the hematologic abnormalities is | chloramphenicol. | Diphyllobothrium latum infestation. | megaloblastic anemia. | myelophthisic anemia. | 3 |
67 | All the following are hormonal agents used against breast cancer EXCEPT : | Letrozole | Exemestane | Taxol | Tamoxifen | 2 |
68 | Which group of anticancer drugs temozolomide belong to : | Oral alkylating agent | Antitumor Antibiotic | Antimetabolite | Mitotic Spindle Inhibitor | 0 |
69 | According to AJCC 8th edition, staging of 2 cm size pancreatic cancer if it involves poal vein in: | T1 | T2 | T3 | T4 | 0 |
70 | Nanotechnology has found tremendous application in the diagnosis of cancers because of all of following advantages, except | Nanocrystals exibit bright, photostable fluorescence | Nonocrystals have a narrow spectrum wavelength | Peak spectrum wavelength is tunable | Nanocrystals exhibit a narrow difference between their excitation and emission peak spectra | 3 |
71 | A 30 year old female presented with unilateral breast cancer associated with axillary lymph node enlargement. Modified radical mastectomy was done, fuher treatment plan will be: | Observation and follow up | Adriamycin based chemotherapy followed by tamoxifen depending on estrogen/progesterone receptor status | Adriamycin based chemotherapy only | Tamoxifen only | 1 |
72 | Most common histological subtype of cancer endometrium is : | Mucinous carcinoma | Clear cell carcinoma | Squamous cell carcinoma | Endometrioid adenocarcinoma | 3 |
73 | Most common lung cancers in non smokers is | Squamous cell carcinoma | Bronchoalveolar carcinoma | Small cell carcinoma | Adenocarcinoma | 3 |
74 | Which of the following is FALSE regarding breast cancer during pregnancy? | Axillary lymph node metastases in 75% of affected women | Mammography is sensitivity during pregnancy | Radiation cannot be considered for treatment | Less than 25% of the breast nodules are cancerous | 1 |
75 | A patient with oral cancer, had ipsilateral lymph node measuring 2 cm, single in number with capsular spread. According to TNM staging it is included under: | Nx | N1 | N2 | N3 | 3 |
76 | Cell cycle specific anti-cancerous drug is? | Cyclophosphamide | Vincristine | Nitrogen mustard | Doxorubicin. | 1 |
77 | Commonest cancer in burn scar is - | Sq. cell Ca | Fibrosarcoma | Adenoa Ca | Adeno-squamous Ca | 0 |
78 | The postoperative quality of life (QOL) scores of 200 prostate cancer patients have a mean of 60 and a standard detion of 10. How many patients are expected to have a QOL score between 40 and 80? | 190 | 136 | 120 | 140 | 0 |
79 | Which one of the following is the most sensitive and specific screening test to detect breast cancer? | Regular X-ray | Self breast examination | Mammography | Regular biopsy | 2 |
80 | Origin of cancer cells in Krukenberg tumour is from: March 2013 | Ovarian carcinoma | Gastric carcinoma | Duodenal carcinoma | Pancreatic carcinoma | 1 |
81 | Pseudomyxoma peritonii is seen in which ovarian cancer? | Serous cystadenocarcinoma | Mucinous cystadenocarcinoma | Brenner Tumor | Fibroma | 1 |
82 | EBV is associated with which type of cancer? | Nasopharyngeal carcinoma | Epidermodysplasia | Kaposi sarcoma | null | 0 |
83 | Cadmium can cause all cancer except- | Lung | Pancreas | Prostate | Skin | 3 |
84 | Most common type of HPV associated with cervical cancer ? | 6, 11 | 5, 8 | 16, 18 | 6, 8 | 2 |
85 | Which of the following pathologic findings is/are the strongest contraindication to breast preservation (lumpectomy with breast radiation) as primary treatment for a newly diagnosed breast cancer? | Grade 3, poorly differentiated, infiltrating ductal carcinoma | Extensive intraductal cancer around the invasive lesion | Tumor size less than 3 cm | Positive surgical margin for invasive cancer | 3 |
86 | If a 95% confidence interval for prevalence of cancer smokers aged> 65 years is 56% to 76%, the chance that the prevalence could be less than 56% is- | Nil | 44% | 2.50% | 5% | 2 |
87 | Which of the following is a triple negative breast cancer - | Colloid Cancer | Secretory cell cancer | Acinic Cell Carcinoma | Mucinous Carcinoma | 1 |
88 | Example for radiation induced cancer is: | Papillary carcinoma thyroid | Follicular carcinoma thyroid | Lymphoma | Hepatoma | 0 |
89 | A 70-year-old woman with a history of ovarian cancer presents with diarrhea. She completed radiation therapy for her cancer 3 months ago. Physical examination shows cachexia, hyperactive bowel sounds, and generalized pallor. The stools are found to contain blood. A CBC shows decreased hemoglobin (7.8 g/dL) and decreased mean corpuscular volume (70 mm3). Which of the following is the most likely cause of GI bleeding in this patient? | Angiodysplasia | Hemorrhoids | Ischemic colitis | Radiation enterocolitis | 3 |
90 | Arrange the following causes of NCD deaths as per decreasing order of frequency? A. Cancers B. Cardiovascular diseases C. Diabetes D. Respiratory diseases | A>D>C>B | D>A>B>C | B>A>D>C | C>B>D>A | 2 |
91 | Virus causing cervical cancer in the ectocervix - | HPV16 | HPV17 | HPV11 | HPV19 | 0 |
92 | Which of the following strategy has been recommended to reduce the heredity risk for ovarian cancer in women with BRCA -1 and BRCA - 2 mutations : | Use of oral contraceptive pills | Screening with transvaginal ultrasound | Screening with CA - 125 | Prophylactic oophorectomy | 3 |
93 | Precancerous lesion of bone among the following is | Paget disease | Chronic osteomyelitis | Benign giant cell tumor | All of the above | 3 |
94 | Cancer management in which of following malignancies has dramatically increased the survival? | Esophagus carcinoma | Glioblastoma multiforme | ALL in children | Cholangiocarcinoma | 2 |
95 | Example for radiation induced cancer is ? | Papillary carcinoma thyroid | Follicular carcinoma thyroid | Lymphoma | Hepatoma | 0 |
96 | Smoking predisposes to all of the following cancers except - | Carcinoma larynx | Carcinoma bladder | Carcinoma stomach | Lymphoma | 3 |
97 | A 70-year-old male Rohan with advanced visceral cancer dies of extensive myocardial infarction. Autopsy also reveals sterile non-destructive vegetations along the mitral leaflet edges. The pathogenesis of this patient's vegetations is most similar to that of: | Hypercalcemia of malignancy | Distant metastases | Trousseau syndrome | Raynaud's phenomenon | 2 |
98 | A patient with cancer developed extreme degree of radiation toxicity. Further history revealed that the dose adjustment of a particular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment during radiotherapy in order to prevent radiation toxicity? | Vincristine | Dactinomycin | Cyclophosphamide | 6- Mercaptopurine | 1 |
99 | Anticancer drug causing nephrotoxicity: September 2009 | Imitanib | Irinotecan | fosfestrol | Cisplatin | 3 |
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