Patent Document ID: 9891108
Application ID: 14432873
Patent Status: 1

Claim One:
1. A method for detecting Alzheimer's disease in a human subject, said method comprising: providing a sample from the human subject, wherein the sample is whole blood, plasma, cerebral spinal fluid, or human serum; subjecting different regions of the sample individually to a Raman spectroscopic analysis to produce a separate Raman spectrum for each of the different regions of the sample, wherein said sample contains biomolecules whose structural, conformational, and compositional variations contribute to differences in the Raman spectra of the sample and wherein said subjecting different regions of the sample individually to a Raman spectroscopic analysis is carried out according to a pre-programmed mapping procedure which detects said variations; subjecting the Raman spectra collected from the different regions of the sample to a statistical analysis; generating a representation of each separate Raman spectrum based on the statistical analysis; preparing Raman spectroscopic signatures for the sample based on the representation for each separate Raman spectrum; determining whether each of the Raman spectroscopic signatures for the sample corresponds to an Alzheimer's disease spectroscopic signature; and identifying a subject as having Alzheimer's disease where the Raman spectroscopic signature for the sample from that subject corresponds to the Raman spectroscopic signature for Alzheimer's disease.