Patent Document ID: 20170193657
Application ID: 15389872
Patent Status: 0

Claim One:
1. A non-transitory computer-readable storage device storing computer executable instructions that when executed by a computer control the computer to perform a method for predicting recurrence of non-small cell lung cancer (NSCLC), the method comprising: accessing an image of a region of tissue demonstrating NSCLC, where the region of tissue includes a cell; defining a segmented cell by segmenting a cell represented in the image from the background of the image; extracting a set of morphological features from the segmented cell, where the set of morphological features includes a shape feature or a color feature; classifying the segmented cell as a tumor infiltrating lymphocyte (TIL) or as a non-TIL based, at least in part, on the set of morphological features; constructing a graph of TIL spatial architecture represented in the image; computing a set of TIL density statistical features based on the graph; providing the set of TIL density statistical features to an automated classifier; receiving, from the automated classifier, a probability that the region of tissue will experience NSCLC recurrence; and controlling a computer aided diagnosis (CADx) system to classify the region of tissue as a non-recurrence region or a recurrence region based, at least in part, on the probability or the graph.