Patent Document ID: 10064584
Application ID: 11643758
Patent Status: 1

Claim One:
1. A system for creating an optical tomographic image of a target volume of an object, the system comprising: an x-ray source configured to direct x-ray radiation into the object; an x-ray detector configured to detect x-ray radiation transmitted through the object; a light source configured to direct light into the object; a light detector configured to detect light transmitted through and/or emitted from the object, wherein the x-ray detector is configured to detect x-ray radiation at a first plurality of angular projections, collecting one or more images of an x-ray scan data set at each of the first plurality of angular projections, and the light detector is configured to detect light at a second plurality of angular projections, collecting one or more images of a light scan data set at each of the second plurality of angular projections; a memory for storing code that defines a set of instructions; and a processor for executing the set of instructions to create a three-dimensional optical absorption map of the target volume based at least in part on the x-ray scan data set and to use the optical absorption map and light scan data set to construct a forward problem and solve an inverse problem in optical tomographic reconstruction, thereby creating the three dimensional optical tomographic image, wherein the optical absorption map reflects anatomical information obtained from the x-ray scan data by distinguishing a plurality of tissues of various densities within the object, wherein the optical absorption map comprises a plurality of absorption coefficients assigned to regions of different densities, where each of the plurality of absorption coefficients is a perturbation from a background absorption coefficient and is computed as a function of an x-ray-derived measure of density, and where each of the plurality of absorption coefficients provides a measure of optical absorption at a wavelength of the detected light.