Patent Document ID: 9720001
Application ID: 14283582
Patent Status: 1

Claim One:
1. A method for detecting, within a sample, the presence or quantity of each of two or more biopolymer molecules of a list of known biopolymer molecules, comprising: calculating, for each biopolymer molecule, a respective list of oligomer molecules predicted to be produced by a chemical reaction or processing of the respective biopolymer molecule; calculating a respective predicted chromatographic elution time period for each unique oligomer molecule of the set of lists of oligomer molecules, said predicted chromatographic elution time periods encompassing a finite retention time period over which a value of a number of co-eluting oligomer molecules is variable with time; calculating, for each unique oligomer molecule, a respective weighted oligomer selection probability, wherein a respective weighting factor assigned to each said oligomer molecule is calculated, in part, as an inverse of a respective number of other of said unique oligomer molecules for which elution times are predicted to overlap with the elution of said each oligomer molecule, based on the predicted chromatographic elution time periods; for each biopolymer molecule, assigning one or more unique oligomer molecules selected from the respective list of oligomer molecules as a proxy for the respective biopolymer molecule, wherein the assigning is performed using the set of weighted oligomer selection probabilities; scheduling a plurality of oligomer detection events of a detection system, wherein each oligomer detection event corresponds to a respective one of the predicted chromatographic elution time periods of the assigned oligomer molecules; performing the chemical reaction or processing of the sample so as to generate a processed sample; introducing the processed sample into a chromatographic system such that oligomers eluting from the chromatographic system, if any, are introduced into the detection system; and operating the detection system so as to search for the presence or quantity of each of the assigned oligomer molecules over the finite retention time period in accordance with the plurality of scheduled oligomer detection events.