Patent Document ID: 8948846
Application ID: 12678377
Patent Status: 1

Claim One:
1. A method, comprising: obtaining a tissue sample exhibiting intracellular motion; using an optical coherence tomography system to acquire a plurality of frames of the tissue sample, each frame comprising optical information about the composition of the sample through a section of the sample acquired over an acquisition interval t; and selecting a time lapse interval for averaging over at least two of the frames, such that the time lapse τ between the at least two frames is selected based on an extent of the intracellular motion of the tissue sample; wherein τ is sufficiently long to reduce speckle noise in images acquired using the optical coherence tomography system due to the intracellular motion, and sufficiently short to reduce image resolution deterioration in images acquired using the optical coherence tomography system; and averaging over the at least two frames to provide an image of the section of the sample.