Patent Document ID: 6132969
Application ID: 09099722
Patent Status: 1

Claim One:
1. A method for testing or confirming a network model for a biological system, said network model comprising: a plurality of input constituents; and a plurality of output classes represented by boolean functions of values of perturbations or modifications to one or more of said input constituents; said method comprising: (a) assigning one or more cellular constituents to a particular output class having a defined change that best matches a measured change, wherein (i) said measured change is provided by data from one or more network testing experiments, said data comprising measured changes in the one or more cellular constituents from a first input state to a second input state, (ii) said defined change is provided by an influence matrix which defines changes of each output class from the first input state to the second input state according to the network model; and (b) determining an overall goodness of fit of said data to the network model, wherein the network model is tested or confirmed by said overall goodness of fit.