Patent Document ID: 10107735
Application ID: 15377659
Patent Status: 1

Claim One:
1. A system for deforming and analyzing a plurality of particles in a sample, the system comprising: a substrate defining a sample inlet; and a fluidic pathway fluidly coupled to the sample inlet, the fluidic pathway comprising: a first focusing region operable to focus particles of the plurality of particles to preferentially align the particles in a first fluid streamline; and a deformation region operable to deform the particles received from the first focusing region, wherein the deformation region is positioned between a first and a second inlet branch substantially coaxially aligned and located on first opposing sides of the deformation region, the first inlet branch fluidly coupled to the first focusing region, and a furcation located upstream of the first focusing region and including a first furcation branch fluidly coupled to the first focusing region and further including a second furcation branch fluidly coupled to the second inlet branch; wherein the deformation region is further positioned between a first and a second outlet branch substantially coaxially aligned and located on second opposing sides of the deformation region, and wherein substantially all of the plurality of particles are shunted to the first furcation branch and wherein substantially particle-free fluid is shunted to the second furcation branch; and wherein the fluidic pathway comprises a second focusing region fluidly coupled to and upstream of the furcation, the second focusing region operable to preferentially align the plurality of particles in a second fluid streamline upstream of the furcation.