Patent Document ID: 9028859
Application ID: 11482599
Patent Status: 1

Claim One:
1. A medical device comprising a phase-separated block copolymer of two or more polymer blocks and the medical device comprising two or more active agents; wherein the phase-separated block copolymer comprises two or more phase domains; wherein a first active agent is preferentially incorporated in a first phase domain and a second active agent is preferentially incorporated in a second phase domain, and wherein the first and the second active agents have different release-rate profiles from the two or more phase domains in the phase-separated block copolymer; wherein the two or more phase domains of the phase-separated block copolymer comprise a hydrophobic phase domain which comprises a hydrophobic block and a hydrophilic phase domain which comprises a hydrophilic block; wherein the first phase domain comprises the hydrophobic phase domain and the second phase domain comprises the hydrophilic phase domain; or the first phase domain comprises the hydrophilic phase domain and the second phase domain comprises the hydrophobic phase domain; wherein the hydrophilic block of the block copolymer comprises a hydrophilic constituent monomer selected from the group consisting of PEG acrylate (PEGA), PEG methacrylate, 2-methacryloyloxyethyl-phosphorylcholine (MPC), n-vinyl pyrrolidone (VP), alkoxymethacrylates, alkoxyacrylates, 2-methacryloylethyl phosphoryl choline, phosphoryl choline methacrylate, 2-acrylamido-2-methyl-1-propanesulfonic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate (SPMA), vinylsulfonic acid, 4-styrenesulfonic acid, 2-allyoxy-2-hydroxypropanesulfonic acid, and combinations thereof; and wherein the hydrophobic block of the block copolymer comprises a hydrophobic constituent monomer selected from the group consisting of 3-hydroxyhexanoate, 4-hydroxyhexanoate, and combinations thereof.