Patent Document ID: 8428319
Application ID: 12764225
Patent Status: 1

Claim One:
1. A method for automatic measurement of morphometric and motion parameters of a coronary target comprising: receiving input data corresponding to the coronary target; extracting reference frames from the input data corresponding to different phases of a cardiac cycle; extracting a three-dimensional centerline model for each phase of the cardiac cycle based on the references frames and projection matrices of the coronary target; tracking a motion of the coronary target through the phases based on the three-dimensional centerline models; and determining a measurement of morphologic and motion parameters of the coronary target based on the motion, wherein the method is embodied in machine readable code executed by a processor, wherein tracking of the motion of the coronary target further comprises: computing a gradient vector flow (GVF) using intermediate images computed from a vesselness filter; formulating a cost function that ensures fidelity to image observations and smooth and cyclic motion priors; and updating, iteratively, tracking parameters and/or deformation models using a first order approximation to a cost function, utilizing a set of linear approximations to a nonlinear cost function.