Patent Document ID: 9336430
Application ID: 13922184
Patent Status: 1

Claim One:
1. A method for computer-assisted karyotyping, comprising: inputting a digitized image of metaphase chromosomes into a processor comprising an image processing module and a classifier module, wherein the image processing module comprises: a segmenting function adapted for segmenting the digitized image for extracting individual chromosome images, wherein the segmenting function comprises measuring a contour of a chromosome border to detect extremes corresponding to telomeres and centromeres; a bend correcting function adapted to straighten images of chromosomes that are bent or curved, wherein the bend correction function comprises an algorithm adapted to conformally map an ideal chromosome to the individual chromosome image; a feature selection function adapted for distinguishing between chromosome bands; wherein the classifier module generates a classification of the image as normal or abnormal and generates an output therefrom.