Patent Document ID: 20140294279
Application ID: 14226226
Patent Status: 0

Claim One:
1. A non-transitory computer-readable storage medium storing computer executable instructions that when executed by a computer cause the computer to perform a method of associating cellular nuclei orientation entropy with malignancy and risk of post-surgical biochemical recurrence (BCR) in a prostate cancer (CaP) patient, the method comprising: accessing a tissue microarray core image (TMA) of a section of a prostate demonstrating pathology associated with CaP in the patient; detecting a cell in a region of interest on the TMA core image; segmenting the boundary of the cell into a set of cell boundary points; calculating a direction of the cell as a function of the set of cell boundary points; constructing a subgraph of a localized cell network within the region of interest by linking individual cells located proximal to each other, where the nodes of the subgraph represent individual cell nuclei centroids, and where the edges of the subgraph are defined between pairs of cells by a probabilistic decaying function; constructing a cellular orientation co-occurrence matrix, where elements of the cellular orientation co-occurrence matrix comprise cell direction pairs, where the cell direction pairs are defined by the subgraph, and where the cellular orientation co-occurrence matrix aggregates co-occurring cell directions as a function of the frequency with which orientations of two individual cells located proximal to each other co-occur; deriving second-order statistics of cell orientations in the localized cell network; selectively differentiating a cancerous tissue region from a non-cancerous tissue region in the image based, at least in part, on the second-order statistics; and establishing a BCR score for the patient based, at least in part, on the second-order statistics.