Patent Document ID: 8504948
Application ID: 13250043
Patent Status: 1

Claim One:
1. A method for designing a biological circuit, comprising: obtaining a target circuit objective for the biological circuit; determining an objective function corresponding to the target circuit objective; obtaining a number of nodes for the biological circuit; obtaining a set of possible circuit subgraphs using the number of nodes; obtaining, by a processor, a specific dissipation energy (SDE) for each one of the set of possible circuit subgraphs by optimizing the objective function, wherein the SDE is a ratio of the heat dissipation rate (HDR) to input mass flux (J) in a non-equilibrium steady state (NESS) system; selecting at least one circuit subgraph from the set of possible circuit subgraphs with the lowest SDE; and designing the biological circuit using the at least one selected one circuit subgraph.