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PUBMED | International journal of audiology | 38690678 | Tone-burst elicited auditory brainstem responses in full-term and pre-term infants. | To investigate the reliability of tone-burst auditory brainstem response (Tuberculosis (TB)-ABR) latencies and thresholds in pre-term and full-term infants | Rance Gary; Tomlin Dani; Graydon Kelley | 2024-01-05 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy | 38690674 | Changes in right ventricular dimensions, function, and pulmonary circulation loading according to the degree of interdialytic weight gain in maintenance hemodialysis patients. | The aim of this study was to investigate changes in echocardiographic right ventricular (Residual Volume (RV)) indices in relation to the degree of fluid accumulation between hemodialysis sessions, evaluated according to the recommended threshold of interdialytic-weight-gain corrected for dry weight (IDWG%) | Anastasiou Vasileios; Theodorakopoulou Marieta P; Kamperidis Vasileios; Daios Stylianos; Tsilonis Konstantinos; Alexandrou Maria-Eleni; Moysidis Dimitrios V; Boutou Afroditi; Giannakoulas George; Ziakas Antonios; Sarafidis Pantelis | 2024-01-05 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Circulation. Arrhythmia and electrophysiology | 38690671 | Impact of Contact Force on Pulsed Field Ablation Outcomes Using Focal Point Catheter. | Conventional focal radiofrequency catheters may be modified to enable multiple energy modalities (radiofrequency or pulsed field [PF]) with the benefit of contact force (Cystic Fibrosis (CF)) feedback, providing greater flexibility in the treatment of arrhythmias. Information on the impact of Cystic Fibrosis (CF) on lesion formation in PF ablations remains limited | Younis Arwa; Santangeli Pasquale; Garrott Kara; Buck Eric; Tabaja Chadi; Wass Sojin Y; Lehn Lauren; Kleve Ryan; Hussein Ayman A; Nakhla Shady; Nakagawa Hiroshi; Taigen Tyler; Kanj Mohamed; Sroubek Jakub; Saliba Walid I; Wazni Oussama M | 2024-01-05 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Thoracic cancer | 38690654 | Pulmonary pleomorphic carcinoma arising in mixed squamous and glandular papilloma: A case report. | Solitary pulmonary papillomas (SPPs) are rare lung neoplasms. Histologically, SPP is classified into three subtypes, and mixed squamous and glandular papilloma (MP) is the rarest subtype. Although SPPs are considered benign tumors, there have been several reports on the synchronous malignant transformation in SPPs. An 82-year-old asymptomatic man was referred to our hospital for further examination of a 2.2 cm-sized left lung tumor. Pathology of bronchoscopic specimens showed the possibility of pulmonary papilloma but did not reveal any malignancy. The patient complained of bloody sputum during the eighth month after the initial visit. The size of the lesion had increased to 4.3 cm. These data suggested the existence of malignancy, and the patient underwent an operation. Histologically, the tumor was composed of fibrovascular cores and papillomatous fronds lined by pseudostratified columnar cells and mucin-filled goblet cells. Keratinizing squamous epithelium was also observed. Overall, the diagnosis of MP was obtained by fundamental histology. In addition, a solid part beneath mild atypical squamous epithelia, which was composed of malignant-appearing squamous cells and spindle-shaped atypical cells, was observed. The spindle portion was positive for cytokeratin AE1/AE3 and vimentin, and focally positive for alpha-smooth muscle actin (αSMA). The final diagnosis was pulmonary pleomorphic carcinoma (PPC) arising in the MP. Only two cases have been reported for atypical spindle tumor cells that are found in MP or bronchiolar adenoma/ciliated muconodular papillary tumor (BA/CMPT), which has histologically similar features to MP. This is the second case report of PPC arising in MP | Nitanda Hiroyuki; Homma Taku; Taguchi Ryo; Umesaki Tetsuya; Ichiki Yoshinobu; Sakaguchi Hirozo; Ishida Hironori | 2024-01-05 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | The Journal of experimental biology | 38690647 | c-fos induction in the choroid plexus, tanycytes and pars tuberalis is an early indicator of spontaneous arousal from torpor in a deep hibernator. | Hibernation is an extreme state of seasonal energy conservation, reducing metabolic rate to as little as 1% of the active state. During the hibernation season, many species of hibernating mammals cycle repeatedly between the active (aroused) and hibernating (torpid) states (T-A cycling), using brown adipose tissue (BAT) to drive cyclical rewarming. The regulatory mechanisms controlling this process remain undefined but are presumed to involve thermoregulatory centres in the hypothalamus. Here, we use the golden hamster (Mesocricetus auratus), and high-resolution monitoring of BAT, core body temperature (Tb), and ventilation rate, to sample at precisely defined phases of the T-A cycle. Using c-fos as a marker of cellular activity we show that although the dorso-medial hypothalamus (DMH) is active during torpor entry, neither it nor the pre-optic area (POA) show any significant changes during the earliest stages of spontaneous arousal. Contrastingly, in 3 non-neuronal sites previously linked to control of metabolic physiology over seasonal and daily time-scales, the choroid plexus (CP), pars tuberalis (PT) and third ventricle tanycytes, peak c-fos expression is seen at arousal initiation. We suggest that through their sensitivity to factors in the blood or cerebrospinal fluid (CSF), these sites may mediate metabolic feedback-based initiation of the spontaneous arousal process | Markussen Fredrik A F; Cázarez-Márquez Fernando; Melum Vebjørn J; Hazlerigg David; Wood Shona | 2024-01-05 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Expert review of respiratory medicine | 38690646 | Preoperative frailty screening in elderly patients with non-small cell lung cancer surgery: an essential step for a good surgical outcome. | Non-small cell lung cancer (NSCLC) is a disease commonly diagnosed in the elderly, often in advanced stages. However, elderly patients with lung cancer can benefit from surgery, provided that postoperative risks are assessed appropriately before surgery. Frailty is a measure of age-related impaired functional status and a predictor of mortality and morbidity. However, its importance as a preoperative marker is not well defined | Antoniu Sabina Antonela; Iacobescu Radu; Popa Alina Delia; Pavel-Tanase Mariana; Stratulat Teodora Alexa | 2024-01-05 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Clinical transplantation | 38690617 | Risk factors for Pneumocystis jirovecii pneumonia after kidney transplantation: A systematic review and meta-analysis. | Pneumocystis jirovecii pneumonia (PJP), an opportunistic infection, often leads to an increase in hospitalization time and mortality rates in kidney transplant (KT) recipients. However, the risk factors associated with PJP in KT recipients remain debatable. Therefore, we conducted this meta-analysis to identify risk factors for PJP, which could potentially help to reduce PJP incidence and improve outcome of KT recipients | Cheng Bingjie; Qi Chang; Zhang Senlin; Wang Xiaowen | 2024-01-05 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Global mental health (Cambridge, England) | 38690575 | " | Stress is a challenge among non-specialist health workers worldwide, particularly in low-resource settings. Understanding and targeting stress is critical for supporting non-specialists and their patients, as stress negatively affects patient care. Further, stigma toward mental health and substance use conditions also impacts patient care. However, there is little information on the intersection of these factors. This sub-analysis aims to explore how substance use and mental health stigma intersect with provider stress and resource constraints to influence the care of people with HIV/Tuberculosis (TB). We conducted semi-structured interviews ( | Hines Abigail C; Rose Alexandra L; Regenauer Kristen S; Brown Imani; Johnson Kim; Bonumwezi Jessica; Ndamase Sibabalwe; Ciya Nonceba; Magidson Jessica F; Myers Bronwyn | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Global mental health (Cambridge, England) | 38690572 | Demographics and risk factors for suicide in Syria: A retrospective media content analysis of online news sources. | Since the beginning of the Syrian conflict in 2011, Syrians have faced violence and displacement causing an increase in mental health issues. The COVID-19 pandemic, the 2023 earthquake, and deteriorating living conditions have exacerbated these issues. Suicide in Syria remains an under-researched topic since accurate data are difficult to obtain. In this study, we aimed to explore the demographics and risk factors of suicide in Syria by performing a retrospective content analysis of selected online news (media) outlets from across Syria. Twelve news outlets from the three regions of Syria were selected and news of suicide cases were searched retrospectively. The age range was between 9 and 79 years old with the average age being 27.1 ± SD 5.9 years. The most reported causes of suicide were harsh living conditions (18.5%) and relationship problems (18.3%). The most common method of suicide was hanging followed by using firearms. More suicides occurred at night and in the summer and spring seasons. Based on our study's results, young adult, male, unmarried, individuals in rural settings and northern governorates were at the highest risk of suicide in Syria. This study highlights the urgent need for mental health interventions that address the unique challenges faced by Syrians | Almidani Salma; Abo Hilal Mohammad; Alghadban Marwa; Abou Helal Omama; Alkourdi Manal; Kannan Juman; Ekzayez Abdulkarim; Patel Preeti; El Achi Nassim | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Computational and structural biotechnology journal | 38690549 | Integrating predictive coding and a user-centric interface for enhanced auditing and quality in cancer registry data. | Data curation for a hospital-based cancer registry heavily relies on the labor-intensive manual abstraction process by cancer registrars to identify cancer-related information from free-text electronic health records. To streamline this process, a natural language processing system incorporating a hybrid of deep learning-based and rule-based approaches for identifying lung cancer registry-related concepts, along with a symbolic expert system that generates registry coding based on weighted rules, was developed. The system is integrated with the hospital information system at a medical center to provide cancer registrars with a patient journey visualization platform. The embedded system offers a comprehensive view of patient reports annotated with significant registry concepts to facilitate the manual coding process and elevate overall quality. Extensive evaluations, including comparisons with state-of-the-art methods, were conducted using a lung cancer dataset comprising 1428 patients from the medical center. The experimental results illustrate the effectiveness of the developed system, consistently achieving F1-scores of 0.85 and 1.00 across 30 coding items. Registrar feedback highlights the system's reliability as a tool for assisting and auditing the abstraction. By presenting key registry items along the timeline of a patient's reports with accurate code predictions, the system improves the quality of registrar outcomes and reduces the labor resources and time required for data abstraction. Our study highlights advancements in cancer registry coding practices, demonstrating that the proposed hybrid weighted neural-symbolic cancer registry system is reliable and efficient for assisting cancer registrars in the coding workflow and contributing to clinical outcomes | Dai Hong-Jie; Chen Chien-Chang; Mir Tatheer Hussain; Wang Ting-Yu; Wang Chen-Kai; Chang Ya-Chen; Yu Shu-Jung; Shen Yi-Wen; Huang Cheng-Jiun; Tsai Chia-Hsuan; Wang Ching-Yun; Chen Hsiao-Jou; Weng Pei-Shan; Lin You-Xiang; Chen Sheng-Wei; Tsai Ming-Ju; Juang Shian-Fei; Wu Su-Ying; Tsai Wen-Tsung; Huang Ming-Yii; Huang Chih-Jen; Yang Chih-Jen; Liu Ping-Zun; Huang Chiao-Wen; Huang Chi-Yen; Wang William Yu Chung; Chong Inn-Wen; Yang Yi-Hsin | 2024-01-12 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Risk management and healthcare policy | 38690537 | Pharmacy-Based Influenza Vaccination: A Study of Patient Acceptance in Romania. | This study explores patient acceptance of influenza vaccination administered by pharmacists in Romania during the 2023 season, considering it a novel strategy to address gaps in knowledge. Pharmacy-based vaccination deviates from traditional methods, providing high-risk patients with full reimbursement and others with 50% reimbursement, allowing a choice between family doctors and pharmacies for vaccine administration | Chirila Sergiu; Hangan Tony; Gurgas Leonard; Costache Monica Georgiana; Vlad Marinela Anisoara; Nitu Bogdan-Florentin; Bittar Sara Melek; Craciun Aurora; Condur Laura; Bjørklund Geir | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Physical therapy research | 38690530 | Early Ambulation Following Lung Resection Surgery: Impact on Short-term Outcomes in Patients with Lung Cancer. | Previous studies indicated that early ambulation following lung resection can prevent postoperative pulmonary complications (PPCs). However, some patients fail to achieve early ambulation owing to factors such as postoperative nausea, vomiting, or pain, particularly on postoperative day 1. This study aimed to address the critical clinical question: Is ambulation for ≥10 m during initial pulmonary rehabilitation necessary after lung resection surgery | Kurata Kazunori; Nagata Yukio; Oki Keisuke; Ono Keishi; Miyake Tomohiro; Inui Kaori; Kobayashi Masashi | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in pediatrics | 38690521 | Adverse respiratory patterns in near-term spontaneously breathing newborn lambs with elevated airway liquid volumes at birth. | Recent evidence indicates that respiratory distress (RD) in near-term infants is caused by elevated airway liquid (EL) volume at the beginning of air-breathing after birth. While the adverse effects EL volumes on newborn lung function are known, the effects on respiratory control and breathing patterns shortly after birth (<4 h) are unknown. We investigated the effects of EL volumes on cardiorespiratory function and breathing patterns in spontaneously breathing near-term newborn lambs in the first hours after birth | Davies I M; Crossley K J; McGillick E V; Nitsos I; Rodgers K; Thiel A; Zahra V A; Badurdeen S; Te Pas A B; Hooper S B | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in pediatrics | 38690520 | Risk factors predicting need for the pediatric intensive care unit (PICU) post-hematopoietic cell transplant, PICU utilization, and outcomes following HCT: a single center retrospective analysis. | Hematopoietic cell transplant (HCT) is a curative treatment for multiple malignant and non-malignant disorders. While morbidity and mortality have decreased significantly over the years, some patients still require management in the pediatric intensive care unit (PICU) during their HCT course for additional respiratory, cardiovascular, and/or renal support. We retrospectively reviewed pediatric patients (0-18 years) who underwent HCT from January 2015-December 2020 at our institution to determine risk factors for PICU care and evaluate PICU utilization and outcomes. We also assessed pulmonary function testing (Pulmonary Function Test (PFT)) data to determine if differences were noted between PICU and non-PICU patients as well as potential evolution of pulmonary dysfunction over time. Risk factors of needing PICU care were lower age, lower weight, having an underlying inborn error of metabolism, and receiving busulfan-based conditioning. Nearly half of PICU encounters involved use of each of respiratory support types including high-flow nasal cannula, non-invasive positive pressure ventilation, and mechanical ventilation. Approximately one-fifth of PICU encounters involved renal replacement therapy. Pulmonary function test results largely did not differ between PICU and non-PICU patients at any timepoint aside from individuals who required PICU care having lower Diffusing Capacity of the Lungs for Carbon Monoxide (DLCO) scores at one-year post-HCT. Future directions include consideration of combining our data with other centers for a multi-center retrospective analysis with the goal of gathering and reporting additional multi-center data to work toward continuing to decrease morbidity and mortality for patients undergoing HCT | Johnson Amanda K; Cornea Sinziana; Goldfarb Samuel; Cao Qing; Heneghan Julia A; Gupta Ashish O | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | World journal of stem cells | 38690515 | Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19. | Coronavirus disease 2019 (COVID-19) is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (Severe Acute Respiratory Syndrome (SARS)-CoV-2). Severe Acute Respiratory Syndrome (SARS)-CoV-2 infection typically presents with fever and respiratory symptoms, which can progress to severe respiratory distress syndrome and multiple organ failure. In severe cases, these complications may even lead to death. One of the causes of COVID-19 deaths is the cytokine storm caused by an overactive immune response. Therefore, suppressing the overactive immune response may be an effective strategy for treating COVID-19. Mesenchymal stem cells (MSCs) and their derived exosomes (MSCs-Exo) have potent homing abilities, immunomodulatory functions, regenerative repair, and antifibrotic effects, promising an effective tool in treating COVID-19. In this paper, we review the main mechanisms and potential roles of MSCs and MSCs-Exo in treating COVID-19. We also summarize relevant recent clinical trials, including the source of cells, the dosage and the efficacy, and the clinical value and problems in this field, providing more theoretical references for the clinical use of MSCs and MSCs-Exo in the treatment of COVID-19 | Hou Xiang-Yi; Danzeng La-Mu; Wu Yi-Lin; Ma Qian-Hui; Yu Zheng; Li Mei-Ying; Li Li-Sha | 2024-26-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690504 | Sinus Tachycardia Following COVID-19 and Its Implications. | Background Within the cardiovascular system, sinus tachycardia has been a noted finding in patients with post-COVID-19 syndrome (symptoms persisting beyond 12 weeks post-infection). To better understand post-COVID-19 tachycardia, we examined the prevalence of sinus tachycardia 12-16 weeks after diagnosis of Severe Acute Respiratory Syndrome (SARS)-COV-2 infection and its correlation with intensive care utilization, ventilator use, and mortality in vaccinated and unvaccinated patients. Methods We identified adult patients in the TriNetX COVID-19 Research Network with confirmed Severe Acute Respiratory Syndrome (SARS)-COV-2 diagnosis from January 20th, 2020, to February 14th, 2022, and sinus tachycardia 12-16 weeks after diagnosis. Two cohorts were created: patients who developed tachycardia 12 weeks after initial diagnosis and patients without tachycardia. The tachycardia cohort was divided further based on vaccination status. Results Of 1,363,907 patients included, 30,705 (2.2%) developed tachycardia. The patients with tachycardia had more comorbidities. Using propensity score matching (PSM), two cohorts of 30,702 were created. The Severe Acute Respiratory Syndrome (SARS)-COV-2 tachycardic cohort had higher mortality (5.1% vs 2.1%, pLess than (<)0.001), critical care utilization (5.8% vs 2.2%, pLess than (<)0.001), and ventilator use (1.8% vs 0.5%, pLess than (<)0.001). Out of 22,878 patients with persistent tachycardia and recorded vaccination status, 14,840 (65%) were not vaccinated. Mortality (5.9% vs 2.3%, pLess than (<)0.001), critical care utilization (8.3% vs 3.6%, pLess than (<)0.001), and ventilator use (3.8% vs 0.6%, pLess than (<)0.001) were higher in the non-vaccinated patients compared with the vaccinated patients after PSM. Conclusion The prevalence of persistent tachycardia after Severe Acute Respiratory Syndrome (SARS)-COV-2 infection is notable at 2.2%. Patients with persistent tachycardia have higher mortality rates and demonstrate greater healthcare utilization at one year compared to patients without persistent tachycardia, particularly if unvaccinated | Amir-Kabirian Borna; Annie Frank H; Koontz Morgan; Ihle Rayan | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690500 | Advancements in Tuberculosis Diagnostics: A Comprehensive Review of the Critical Role and Future Prospects of Xpert MTB/RIF Ultra Technology. | Tuberculosis remains a persistent global health challenge, demanding swift and accurate diagnostic methods for effective treatment. The emergence of the Xpert MTB/RIF Ultra system marks a significant milestone in combating tuberculosis, streamlining the identification of | Yadav Sankalp; Rawal Gautam; Jeyaraman Madhan; Jeyaraman Naveen | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690499 | Successful Atrial Septal Defect Closure Subsequent to Medical Pulmonary Preconditioning in an Infant With Severe Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia. | While atrial septal defect (ASD) may contribute to right ventricular decompression in patients with severe pulmonary hypertension (PH), the pulmonary vasculature might be compromised by increased pulmonary blood flow, even though pulmonary vasodilators successfully reduce resistance. ASD closure is a treatment option that may ameliorate PH symptoms associated with bronchopulmonary dysplasia (BPD) in infants. However, the feasibility of ASD closure is obscure in patients with BPD-PH causing right-to-left shunting. Here, we present an eight-month-old girl with ASD complicated by BPD-PH, in which the pulmonary pressure exceeded the systemic pressure; the ASD was successfully closed after pulmonary preconditioning with dexamethasone and high-dose diuretics. Our patient was delivered as the third baby in triplets at a gestational age of 25 weeks, with a birth weight of 344 g. She was diagnosed with BPD at three months of age (37 weeks of postmenstrual age) with a body weight of 1.4 kg. Mild pulmonary hypertension was identified at the age of five months, and oral sildenafil was initiated. While her atrial septal defect was small at the time of PH diagnosis, it became hemodynamically significant when she grew up to 3.4 kg of body weight, at seven months after birth. Her estimated right ventricular pressure was apparently more than the systemic pressure, and oxygen saturation fluctuated between 82% and 97% under oxygen supplementation due to bidirectional interatrial shunt with predominant right-to-left shunting. Pulmonary preconditioning lowered the estimated right ventricular pressure to almost equal the systemic pressure and elevated arterial oxygen saturation while also suppressing right-to-left shunting. Cardiac catheterization after preconditioning revealed a ratio of pulmonary blood pressure to systemic blood pressure ratio (Pp/Ps) of 0.9, pulmonary resistance of 7.3 WU-m | Sato Maki; Saiki Hirofumi; Saito Kanchi; Sato Akira; Kuwata Seiko; Nakano Satoshi; Koizumi Junichi; Oyama Kotaro; Akasaka Manami | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690498 | Ultrasound-Facilitated, Catheter-Directed Thrombolysis for Acute Pulmonary Embolism. | Acute pulmonary embolism (APE) poses a significant risk to patient health, with treatment options varying in efficacy and safety. Ultrasound-facilitated catheter-directed thrombolysis (USCDT) has emerged as a potential alternative to conventional catheter-directed thrombolysis (CDT) for patients with intermediate to high-risk APE. This study aimed to compare the efficacy and safety of USCDT versus conventional CDT in patients with intermediate to high-risk APE | Elheet Ahmed A; Elhadidy Amr F; Farrag Mohamad H; Mahmoud Mohamed A; Ibrahim Ayman A; AlAbdali Ali M; Kazim Hameedullah; Elganainy Mohammed N | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690490 | Malignant Pericardial Effusion Presenting as a Sequela of Lung Adenocarcinoma. | Pericardial effusion is a collection of fluid in the pericardial sac that can result in symptoms such as shortness of breath, pleuritic chest pain, and/or hemodynamic instability. Malignant pleural effusions are seen in a few cancer patients and are associated with poor prognosis. Here, we present the case of a 65-year-old female with a large malignant pericardial effusion in the setting of advanced-stage lung adenocarcinoma | Balaji Nivedha; Velez Oquendo Gabriel; Sun Moyan; Sykalo Christine; Khan Imran | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690487 | An Observational Study of Fungal Infections in COVID-19: Highlighting the Role of Mucormycosis in Tertiary Healthcare Settings. | Background Fungal infections, especially mucormycosis, have remarkably surged during the coronavirus disease 2019 (COVID-19) era, especially during the second wave peak of the pandemic raising the concern of the clinicians for the admitted patients. Steroid therapy, diabetes, and other immunocompromised states are more commonly associated with COVID-19-associated mucormycosis (CAM). Aim and objective The aim of this study is to ascertain the prevalence of fungal infections amidst the second wave of the COVID-19 pandemic and discern the associated risk factors. Materials and methods During the second peak of COVID-19, samples were received in the microbiology laboratory from all clinically suspected mucormycosis patients. These samples underwent processing for potassium hydroxide (KOH) wet mount, fungal culture on Sabouraud's dextrose agar (SDA) medium, and COVID-19 reverse transcription-polymerase chain reaction (RT-Polymerase Chain Reaction (PCR)) testing. All relevant clinical and associated risk factors were tabulated and analyzed. Results Among the 107 suspected cases of mucormycosis, 39 (36.4%) were confirmed positive for COVID-19 via RT-Polymerase Chain Reaction (PCR), while 68 (63.6%) tested negative. Males exhibited a predominant infection rate, with the rhinocerebral system being the most commonly affected site. Significantly higher mortality rates were observed in COVID-19-associated mucormycosis (CAM) patients (33.4%) compared to those without COVID-19 (5.9%), with a notable p-value of 0.0005. CAM patients also demonstrated a higher frequency of Intensive Care Unit (ICU) admissions (77%) compared to non-COVID-19-associated mucormycosis patients (21.4%), a statistically significant finding (p-value of 0.007). Additionally, immunocompromised states, diabetes, and the administration of oxygen therapy were identified as significant risk factors in CAM (p < 0.05). Notably, mucormycosis accounted for the majority of fungal isolates (48.27%) among COVID-19 patients. Conclusion Mucormycosis infection is more commonly seen in COVID-19-infected patients as compared to non-COVID-19 patients, especially with comorbidities such as diabetes mellitus, steroid usage, and other immunocompromised states | Singh Rajender; Mittal Garima; Kakati Barnali; Koul Nupur | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690483 | Impact of COVID-19 Pandemic on Radiology Department Employees and Trainees in Al-Qassim, 2021. | Objectives This study aimed to assess the impact of the COVID-19 pandemic on radiology department employees and trainees. It also compared the impact of COVID-19 to the pre-COVID-19 era in the Al-Qassim region. Methods This was a quantitative observational analytical cross-sectional study conducted in the largest government hospitals under the Ministry of Health (MOH) in Al-Qassim. A pre-determined questionnaire was distributed among radiology staff that included demographic characteristics, the impact of the COVID-19 pandemic among radiology staff, the behavior of staff related to COVID-19 infection, and the assessment of mental health using the patient health questionnaire (PHQ-9). Results Eighty-four radiology staff were recruited (64.3% males vs 35.7% females). Of these, 66.7% were trainees and the rest were employees (33.3%). Of the trainees, 32.1% and 42.9% thought that elective imaging, procedures, and outpatient/clinic exposures were reduced during the pandemic, and 37.5% indicated that their training had been affected negatively. The prevalence of depression among radiology staff was 36.9%. The prevalence of depression was substantially higher among radiology trainees (p=0.038), those who were not infected with COVID-16 (p=0.041), and those who indicated that their studying time increased at the time of the pandemic (p=0.047). However, after conducting multivariate regression analysis, these variables did not seem to have significantly affected depression (pGreater than (>)0.05). Conclusion Training and medical education have been affected negatively because of the outbreak. Studying time and research activities of employees and trainees slowed down, which could be critical to their careers. Trainees complained about the significant reduction in their exposure to clinics and imaging procedures. Therefore, a method to safeguard the well-being of employees and trainees in the radiology department is necessary to limit the impact of such pandemics | Albweady Ali; AlHajji Maryiah; AlBassam Rawaf; Almalki Hala; Almansour Beshair; Alghofaili Renad; Alsubaie Manal | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690482 | Novelty of Physiotherapy Management in a Classic Case of Chronic Obstructive Pulmonary Disease in an 84-Year-Old Male Patient with Hypertension and Well-Controlled Hypothyroidism: A Case Report. | Chronic obstructive pulmonary disease (Chronic Obstructive Pulmonary Disease (COPD)) often coexists with hypertension and hypothyroidism, posing challenges in management. Physiotherapy is crucial for improving respiratory function and quality of life in Chronic Obstructive Pulmonary Disease (COPD) patients. This case report details the physiotherapy management of an 84-year-old male with Chronic Obstructive Pulmonary Disease (COPD), hypertension, and well-controlled hypothyroidism. The patient presented with worsening cough, breathlessness, and barrel chest. Diagnostic investigations confirmed Chronic Obstructive Pulmonary Disease (COPD) with respiratory alkalosis, hypoxemia, and well-controlled hypothyroidism. Pharmaceutical management was initiated alongside intensive physiotherapy interventions. A two-week rehabilitation program was tailored to the patient's Chronic Obstructive Pulmonary Disease (COPD) condition. It included deep breathing exercises, relaxation techniques, and aerobic activities to improve respiratory function and exercise tolerance. Physiotherapy sessions focused on patient education with medical treatment. Significant improvements were noted in dyspnea grading, perceived exertion rate, and thoracic excursion post-rehabilitation. Follow-up assessments showed sustained benefits with improved daily activities and reduced dyspnea. This case underscores the efficacy of multidisciplinary management, highlighting the essential role of physiotherapy in optimizing outcomes for Chronic Obstructive Pulmonary Disease (COPD) patients with comorbidities | Nangliya Radha; Yadav Vaishnavi; Nandanwar Sojwal P | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690481 | Efficacy of Computerized Tomography-Guided Core Biopsy in Identifying the Subtypes of Lung Adenocarcinoma: An Observational Perspective From Pakistan. | Background Lung carcinoma is a leading cause of death worldwide. Histological subtype of lung adenocarcinoma is an important indicator of patient's outcome as it is helpful in surgical planning and guidance of prognosis. Objective To determine the diagnostic efficacy of computerized tomography-guided core needle biopsy (CNB) in identifying the histopathological subtype of lung adenocarcinoma. Methods and materials This is a retrospective, descriptive study including clinical data of 73 patients irrespective of their age and gender, who underwent computerized tomography-guided CNB for lung masses at the Department of Pathology, Aznostics - the Diagnostic Centre, Lahore, Pakistan from January 01, 2019 to June 30, 2023. Data collected was analyzed via Google Form (Google Inc., Mountainview, CA) and Statistical Package for Social Sciences (IBM SPSS Statistics for Windows, Version 24, released 2016; IBM Corp., Armonk, New York, United States) and was sent to statistician for descriptive analysis. Categorical data was used for calculating frequency and percentage, while continuous data was computed as mean and standard deviation. Results Seventy-three patients with adenocarcinoma underwent pulmonary biopsy. The mean age of included patients was 64.88 ± 11.39 year with a male predominance of 61.64%. Upper lobe was commonly affected by adenocarcinoma lung in 57.53% patients and 58.90% cases involved the right lung. The most common subtype was acinar with 51.65% followed by solid with 17.58% cases. Computerized tomography-guided CNB showed a diagnostic yield of 75.34% and identified histological subtypes of lung adenocarcinoma in 55 cases. Conclusion Computerized tomography-guided CNB is a useful, yet minimally invasive diagnostic tool to identify the histological subtype of lung adenocarcinoma. It not only helps in planning the surgical and adjuvant management of the patients, but also guides the patient-prognosis | Yasin Babar; Saeed Hasan; Ahmad Muhammad Awais; Najam Sara; Niazi Mehwish; Tariq Humza; Khan Allah Yar Yahya; Khaliq Shoaib; Zaidi Syeda Gul E Zehra; Mehmood Qadri Haseeb | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690475 | Clinical Features Predicting COVID-19 Severity Risk at the Time of Hospitalization. | The global spread of COVID-19 has led to significant mortality and morbidity worldwide. Early identification of COVID-19 patients who are at high risk of developing severe disease can help in improved patient management, care, and treatment, as well as in the effective allocation of hospital resources. The severity prediction at the time of hospitalization can be extremely helpful in deciding the treatment of COVID-19 patients. To this end, this study presents an interpretable artificial intelligence (AI) model, named COVID-19 severity predictor (CoSP) that predicts COVID-19 severity using the clinical features at the time of hospital admission. We utilized a dataset comprising 64 demographic and laboratory features of 7,416 confirmed COVID-19 patients that were collected at the time of hospital admission. The proposed hierarchical CoSP model performs four-class COVID severity risk prediction into asymptomatic, mild, moderate, and severe categories. CoSP yielded better performance with good interpretability, as observed via Shapley analysis on COVID severity prediction compared to the other popular ML methods, with an area under the received operating characteristic curve (AUC-ROC) of 0.95, an area under the precision-recall curve (AUPRC) of 0.91, and a weighted F1-score of 0.83. Out of 64 initial features, 19 features were inferred as predictive of the severity of COVID-19 disease by the CoSP model. Therefore, an AI model predicting COVID-19 severity may be helpful for early intervention, optimizing resource allocation, and guiding personalized treatments, potentially enabling healthcare professionals to save lives and allocate resources effectively in the fight against the pandemic | Sagar Dikshant; Dwivedi Tanima; Gupta Anubha; Aggarwal Priya; Bhatnagar Sushma; Mohan Anant; Kaur Punit; Gupta Ritu | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690473 | From Campus to Crisis: Psychological Effect of the COVID-19 Pandemic on Indian Management Students. | The COVID-19 pandemic has adversely affected students pursuing higher education, but limited studies highlight student's psychological experiences, especially from Western India | Panchamia Jallavi; Sinha Anamika; Pandya Apurvakumar | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690470 | Multifaceted Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on ST-Elevation Myocardial Infarction (STEMI): A Literature Review of Incidence, Treatment Modalities, and Outcomes. | The global repercussions of coronavirus disease 2019 (COVID-19) include substantial worldwide mortality and have brought to light existing gaps in healthcare systems. Particularly, diseases requiring time-sensitive treatment, such as ST-elevation myocardial infarction (STEMI), have faced significant challenges due to the impact and revelations of the COVID-19 pandemic on healthcare infrastructure. This review addresses the impact of the pandemic on STEMI, exploring incidence, treatment modalities, and clinical outcomes. Through a critical examination of existing literature, the intricate relationship between the pandemic and cardiovascular health, specifically STEMI, is elucidated. The COVID-19 pandemic has had a significant impact on the management of STEMI, with changes in hospitalization rates, treatment strategies, and the presentation of the disease posing significant challenges. The contradictory results of COVID-19 and post-vaccine myocardial infarction, as well as gender differences in reported cases, highlight the need for further research to clarify these relationships | Choi Hoi K; Maity Madhurima; Qureshi Mohammed; Haider Ali; Kapadia Sagar; Fuerte Sofia; Antony Simon; Razzaq Waleed; Akbar Anum | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690469 | A Case of COVID-19 Pneumonia Leading to Acute Respiratory Distress Syndrome (ARDS) and Multi-organ Failure Requiring Extracorporeal Membrane Oxygenation (ECMO) for Six Months and an Associated Critical Limb Ischemia. | This article presents the case of a 57-year-old woman with a history of rheumatoid arthritis who developed severe coronavirus disease 2019 (COVID-19) pneumonia that progressed to acute respiratory distress syndrome (Acute Respiratory Distress Syndrome (ARDS)) and multi-system organ failure. Despite initial slow progression and multiple hospital readmissions, her condition rapidly deteriorated, leading to full respiratory failure requiring intubation and ventilation. She was transferred to a specialized center where she underwent extracorporeal membrane oxygenation (ECMO) and hemodialysis for acute renal failure. Unfortunately, she remained dependent on ECMO for an extended period of six months. Although she made a gradual recovery, the prolonged critical care treatment resulted in critical ischemia of multiple extremities, necessitating a below-knee amputation (BKA) of her left lower extremity and transmetatarsal amputations of her right hand. This case reports one of the longest ECMO treatments for COVID-19 and associated comorbidities in the literature. Clinicians could include a longer duration of treatment and potential associated disabilities in the informed consent | Durrani Kulsoom; Butt Faiza; Atif Syed; Azhar Erum; Waheed Abdul | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690468 | Prevalence of Pulmonary Hypertension in Liver Cirrhosis Patients: A Cross-Sectional Analytical Study. | Liver cirrhosis (LC) is a common complication of chronic liver disease. Its prevalence has increased markedly over the last few years. With liver cirrhosis comes cardiovascular morbidity and mortality. It is important that the detection of the abnormalities by echocardiography be given priority, as this can change the clinical outcome of these patients with cardiovascular abnormalities in liver cirrhosis | Enenche Augustine A; Kweki Anthony G; Aiwuyo Henry O; Akinti Oluwasegun M; Nevolina Anna; Perry Jamal C; Ayinalem Yonael; Osarenkhoe John O; Ukenenye Emmanuel; Poluyi Charles O; Ibrahim Aishatu O | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690457 | Survival and Lung Function Changes in Hypersensitivity Pneumonitis According to Radiological Phenotypes Compared With Idiopathic Pulmonary Fibrosis. | The main objective of this study was to estimate survival and changes in lung function in patients with chronic hypersensitivity pneumonitis (HP), both fibrotic (f-HP) and nonfibrotic (nf-HP), and to compare them with those in patients with idiopathic pulmonary fibrosis (IPF) | Juliá-Serdá Gabriel; Navarro-Esteva Javier; Doreste-Salgado Laura; Véliz-Flores Ibrahim; Pestana-Santana Rubén; González-Martín Jesús María; Rodríguez-de Castro Felipe | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690453 | Post-COVID-19 Pulmonary Inflammatory Pseudotumors Treated With Steroid Taper. | The aftermath of COVID-19 continues to unveil an array of pulmonary complications, extending beyond the acute phase of the viral infection. Among these emerging sequelae, we present the case of a 58-year-old individual who developed pulmonary inflammatory pseudotumors (PIPs) following recovery from COVID-19. PIPs are exceedingly rare benign lesions that can pose a diagnostic challenge due to their clinical and radiological resemblance to malignant neoplasms. Histologically, PIPs are characterized by a proliferation of myofibroblastic spindle cells accompanied by inflammatory infiltrates, including lymphocytes, plasma cells, and histiocytes. As our understanding of post-COVID-19 complications evolves, this case serves as the first exploration into the complex interplay between COVID-19 infections and the subsequent development of inflammatory pseudotumors. In this report, an investigation is performed into the clinical presentation, diagnostic challenges, and successful management of post-COVID-19 PIPs with a focus on the pivotal role of corticosteroid therapy in mitigating the inflammatory response associated with this unique post-viral entity and resolution of the masses | Karimi Rayhan; Adlakha Arun | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Cureus | 38690449 | A Less Invasive Technique for Surfactant Administration in a Full-Term Newborn With Moderate Meconium Aspiration Syndrome. | Meconium aspiration syndrome (MAS) presents significant challenges in neonatal care, particularly in the context of respiratory distress. This report explores the efficacy of administering surfactant through a less invasive surfactant administration (LISA) technique in a full-term neonate with MAS. Our case highlights the potential of this method in reducing the need for mechanical ventilation, drawing parallels with its established benefits in preterm neonates with respiratory distress syndrome. The successful application of LISA in this case suggests a promising avenue for managing MAS in full-term neonates, warranting further investigation | Abusallout Nuor; Abdulrahman Sarah; Elhadidi Ahmed; Ben Ayad Aimen | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690443 | The effect of donor-recipient sex matches on lung transplant survival: An analysis of the United Network for Organ Sharing database. | To investigate the impact of donor-recipient (DR) sex matches on survival after lung transplantation while controlling for size difference in the United Network of Organ Sharing (UNOS) database | Profozich Elizabeth; Kashem Abul; Yanagida Roh; Suryapalam Manish; Cheng Ke; Kehara Hiromu; Shigemura Norihisa; Toyoda Yoshiya | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690442 | Mortality index is more accurate than volume in predicting outcome and failure to rescue in Medicare beneficiaries undergoing robotic right upper lobectomy. | Surgical volume is known to influence failure to rescue (FTR), defined as death following a complication. Robotic lung surgery continues to expand and there is variability in outcomes among hospitals. We sought to estimate the contribution of hospital-based factors on outcomes and FTR following robotic right upper lobectomy (RRUL) | Hayanga J W Awori; Tham Elwin; Gomez-Tschrnko Manuel; Mehaffey J Hunter; Lamb Jason; Rothenberg Paul; Badhwar Vinay; Toker Alper | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690441 | Randomized controlled trials in lung cancer surgery: How are we doing? | Randomized control trials are considered the highest level of evidence, yet the scalability and practicality of implementing randomized control trials in the thoracic surgical oncology space are not well described. The aim of this study is to understand what types of randomized control trials have been conducted in thoracic surgical oncology and ascertain their success rate in completing them as originally planned | Wong Lye-Yeng; Li Yanli; Elliott Irmina A; Backhus Leah M; Berry Mark F; Shrager Joseph B; Oh Daniel S | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690438 | Debunking the July Effect in lung transplantation recipients. | The "July Effect" is a theory that the influx of trainees from July to September negatively impacts patient outcomes. We aimed to study this theoretical phenomenon in lung transplant recipients given the highly technical nature of thoracic procedures | Kalra Andrew; Ruck Jessica M; Akbar Armaan F; Zhou Alice L; Leng Albert; Casillan Alfred J; Ha Jinny S; Merlo Christian A; Bush Errol L | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690435 | Surgical pulmonary arterioplasty at bidirectional cavopulmonary anastomosis leads to favorable pulmonary hemodynamics at final stage palliation. | Pulmonary arterioplasty (PA plasty) at bidirectional cavopulmonary anastomosis (BDCA) is associated with increased morbidity, but outcomes to final stage palliation are unknown. We sought to determine the influence of PA plasty on pulmonary artery growth and hemodyamics at Fontan | Olds Anna; Gray W Hampton; Bojko Markian; Weaver Carly; Cleveland John D; Bowdish Michael E; Wells Winfield J; Starnes Vaughn A; Kumar S Ram | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690426 | The cost of lung transplantation in the United States: How high is too high? | To identify patient and process factors that contribute to the high cost of lung transplantation (LTx) in the perioperative period, which may allow transplant centers to evaluate situations in which transplantation is most cost-effective to inform judicious resource allocation, avoid futile care, and reduce costs | Harris Chelsea S; Lee Hui-Jie; Alderete Isaac S; Halpern Samantha E; Gordee Alexander; Jamieson Ian; Scales Charles; Hartwig Matthew G | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690424 | Use of a novel microbiome modulator improves anticancer immunity in a murine model of malignant pleural mesothelioma. | Malignant pleural mesothelioma is a fatal disease and a clinical challenge, as few effective treatment modalities are available. Previous evidence links the gut microbiome to the host immunoreactivity to tumors. We thus evaluated the impact of a novel microbiome modulator compound (MMC) on the gut microbiota composition, tumor immune microenvironment, and cancer control in a model of malignant pleural mesothelioma | Gattlen Christophe; Frank Kirby R; Marie Damien N; Trompette Aurélien; Chriqui Louis-Emmanuel; Hao Yameng; Abdelnour Etienne; Gonzalez Michel; Krueger Thorsten; Dyson Paul J; Siankevich Sviatlana; von Garnier Christophe; Ubags Niki D J; Cavin Sabrina; Perentes Jean Y | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690420 | Oncological feasibility of segmentectomy for inner-located lung cancer. | Oncological feasibility of segmentectomy for internal non-small cell lung cancer (NSCLC) has not been assessed adequately. We assessed the oncological feasibility of segmentectomy for inner-located NSCLC by investigating surgical margins and patient prognosis after undergoing the procedure | Yano Kaito; Yotsukura Masaya; Watanabe Hirokazu; Akamine Takaki; Yoshida Yukihiro; Nakagawa Kazuo; Yatabe Yasushi; Kusumoto Masahiko; Watanabe Shun-Ichi | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690419 | En bloc chest wall resection in locally advanced cT3N2 (stage IIIB) lung cancer involving the chest wall: Revisiting guidelines. | Current National Comprehensive Cancer Network guidelines recommend definitive chemoradiation rather than surgery for patients with locally advanced clinical stage T3 and N2 (stage IIIB) lung cancer involving the chest wall. The data supporting this recommendation are controversial. We studied whether surgery confers a survival advantage over definitive chemoradiation in the National Cancer Database | Zywiciel Joseph F; Verm Raymond A; Raad Wissam; Baker Marshall; Freeman Richard; Abdelsattar Zaid M | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690416 | Determining optimal air leak resolution criteria when using digital pleural drainage device after lung resection. | There is limited clinical evidence to support any specific parenchymal air leak resolution criteria when using digital pleural drainage devices following lung resection. The aim of this study is to determine an optimal air leak resolution criteria, where duration of chest tube drainage is minimized while avoiding complications from premature chest tube removal | Alayche Mohsen; Choueiry Justen; Mekdachi Adnan; Maziak Donna E; Seely Andrew J E; Sundaresan Sudhir R; Villeneuve Patrick J; Jones Daniel; Klement William; Gilbert Sebastien | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690414 | Lung volume reduction surgery is safe and leads to functional improvement in patients who fail or cannot undergo bronchoscopic lung volume reduction. | Bronchoscopic lung volume reduction (BLVR) has supplanted surgery in the treatment of patients with advanced emphysema, but not all patients qualify for it. Our study aimed to investigate the outcomes of lung volume reduction surgery (LVRS) among patients who either failed BLVR or were not candidates for it | Magarinos Jessica; Egelko Aron; Criner Gerard J; Abbas Abbas; Enofe Nosayaba; Thomas JiJi; Carney Kevin; Friedberg Joseph; Bakhos Charles | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690413 | Human immunodeficiency virus infection is associated with greater risk of pneumonia and readmission after cardiac surgery. | Human immunodeficiency virus infection (HIV+) is associated with a 2-fold increased risk of cardiovascular disease. Increasingly, patients who are HIV + are being evaluated to undergo cardiac surgery. Current risk-adjusted scoring systems, including the Society of Thoracic Surgeons Predicted Risk of Mortality score, fail to stratify HIV + risk. Unfortunately, there exists a paucity of cardiac surgery outcomes data in modern patients who are HIV+ | Zadeh Ali Vaeli; Justicz Alexander; Plate Juan; Cortelli Michael; Wang I-Wen; Melvan John Nicholas | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690409 | Tracheostomy is associated with decreased vasoactive-inotropic score in postoperative cardiac surgery patients on prolonged mechanical ventilation. | We sought to quantify the influence that tracheostomy placement has on the hemodynamic stability of postoperative cardiac surgery patients with persistent ventilatory requirements | O'Shea Thomas F; Franko Lynze R; Paneitz Dane C; Shelton Kenneth T; Osho Asishana A; Auchincloss Hugh G | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JTCVS open | 38690408 | An angiotensin system inhibitor (losartan) potentiates antitumor efficacy of cisplatin in a murine model of non-small cell lung cancer. | Previous studies have demonstrated synergistic antitumor effects of angiotensin system inhibition (ASI) combined with cisplatin therapy in pancreatic cancer. This study examines whether or not synergistic antitumor effects occur with combination ASI and cisplatin treatment in lung cancer, and whether or not ASI-induced changes in epithelial-mesenchymal transition play a role in the mechanism of this antitumor phenomenon | Tang Hexiao; Abston Eric; Sojoodi Mozhdeh; Wang Yongtao; Erstad Derek J; Lin Zenan; Fuchs Bryan C; Tanabe Kenneth K; Lanuti Michael | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in microbiology | 38690371 | The airway microbiome of persons with cystic fibrosis correlates with acquisition and microbiological outcomes of incident | Chronic infection with | Bowron Lauren A; Acosta Nicole; Thornton Christina S; Carpentero Jennifer; Waddell Barbara-Jean M; Bharadwaj Lalit; Ebbert Kirsten; Castañeda-Mogollón Daniel; Conly John M; Rabin Harvey R; Surette Michael G; Parkins Michael D | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in cellular and infection microbiology | 38690325 | Infection with the multidrug-resistant Klebsiella pneumoniae New Delhi metallo-B-lactamase strain in patients with COVID-19: | During the coronavirus disease 2019 (COVID-19) pandemic, in patients treated for Severe Acute Respiratory Syndrome (SARS)-CoV-2 infection, infections with the | Janc Jarosław; Słabisz Natalia; Woźniak Anna; Łysenko Lidia; Chabowski Mariusz; Leśnik Patrycja | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Data in brief | 38690314 | Digital skills among youth: A dataset from a three-wave longitudinal survey in six European countries. | This dataset provides longitudinal survey data from a European project, ySKILLS, which was focused on the role of digital skills in youths' development. It contains data from 10,821 participants from Grades 6-10 (in Wave 1) in Estonia, Finland, Germany, Italy, Poland, and Portugal. The data was collected between Spring 2021 and Spring 2023, the participants were recruited through schools, where the data collection also took place, except for online data collections due to restrictions caused by COVID-19. The dataset is novel in its multidimensional approach to the construct of digital literacy. It provides insight into the development of digital skills in youth and the role of digital skills and internet usage in youths' positive and negative online experiences and wellbeing. It also contains data that allows for the analysis of the role of digital skills in class networks. The data are beneficial for researchers interested in the examination of youths' online skills, internet usage, online experiences, and wellbeing from a longitudinal perspective | Machackova Hana; Jaron Bedrosova Marie; Muzik Michal; Zlamal Rostislav; Fikrlova Jana; Literova Anna; Dufkova Eliska; Smahel David; Boomgaarden Hajo; Song Hyunjin; Tolochko Petro; d'Haenens Leen; Joris Willem; Kalmus Veronika; Tikerperi Mari-Liis; Opermann Signe; Napp Marit; Soidla Indrek; Uibos Andre; Soo Kadri; Salmela-Aro Katariina; Järvinen Jussi; Mannerström Rasmus; Suvila Erkki; Waechter Natalia; Brando Christin; Kadera Stepanka; Mascheroni Giovanna; Cino Davide; Lombi Linda; van Deursen Alexander; van Laar Ester; Pyżalski Jacek; Walter Natalia; Iwanicka Agnieszka; Ponte Cristina; Batista Susana; Baptista Rita; Schneider Luc; Helsper Ellen Johanna | 2024-01-06 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in immunology | 38690286 | The effects of | Inflammatory cytokines have crucial roles in the pathogenesis of tuberculosis (Tuberculosis (TB)), and interleukin (Interleukin (IL))-27 and Interleukin (IL)-35 have a pro-inflammatory and anti-inflammatory effect on many diseases, including infectious diseases. Therefore, we evaluated the relationship between | Gao Lei; Xiong Yan-Jun; Liang Ya-Xue; Huang Peng-Fei; Liu Shuang; Xiao Yu; Huang Qian; Wang Hua; Wu Hui-Mei | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in immunology | 38690277 | Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension. | Hypoxia is a common pathological driver contributing to various forms of pulmonary vascular diseases leading to pulmonary hypertension (PH). Pulmonary interstitial macrophages (IMs) play pivotal roles in immune and vascular dysfunction, leading to inflammation, abnormal remodeling, and fibrosis in PH. However, IMs' response to hypoxia and their role in PH progression remain largely unknown. We utilized a murine model of hypoxia-induced PH to investigate the repertoire and functional profiles of IMs in response to acute and prolonged hypoxia, aiming to elucidate their contributions to PH development | Kumar Sushil; Mickael Claudia; Kumar Rahul; Prasad Ram Raj; Campbell Nzali V; Zhang Hui; Li Min; McKeon B Alexandre; Allen Thaddeus E; Graham Brian B; Yu Yen-Rei A; Stenmark Kurt R | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in immunology | 38690274 | Clinical and immunological comparison of COVID-19 disease between critical and non-critical courses: a systematic review and meta-analysis. | Acute Respiratory Syndrome Coronavirus 2 (Severe Acute Respiratory Syndrome (SARS)-CoV-2), which appeared in 2019, has been classified as critical and non-critical according to clinical signs and symptoms. Critical patients require mechanical ventilation and intensive care unit (Intensive Care Unit (ICU)) admission, whereas non-critical patients require neither mechanical ventilation nor Intensive Care Unit (ICU) admission. Several factors have been recently identified as effective factors, including blood cell count, enzymes, blood markers, and underlying diseases. By comparing blood markers, comorbidities, co-infections, and their relationship with mortality, we sought to determine differences between critical and non-critical groups | Hedayati-Ch Mojtaba; Ebrahim-Saraie Hadi Sedigh; Bakhshi Arash | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in immunology | 38690272 | Trivalent mRNA vaccine-candidate against seasonal flu with cross-specific humoral immune response. | Seasonal influenza remains a serious global health problem, leading to high mortality rates among the elderly and individuals with comorbidities. Vaccination is generally accepted as the most effective strategy for influenza prevention. While current influenza vaccines are effective, they still have limitations, including narrow specificity for certain serological variants, which may result in a mismatch between vaccine antigens and circulating strains. Additionally, the rapid variability of the virus poses challenges in providing extended protection beyond a single season. Therefore, messenger Ribonucleic Acid (mRNA) technology is particularly promising for influenza prevention, as it enables the rapid development of multivalent vaccines and allows for quick updates of their antigenic composition. messenger Ribonucleic Acid (mRNA) vaccines have already proven successful in preventing COVID-19 by eliciting rapid cellular and humoral immune responses. In this study, we present the development of a trivalent messenger Ribonucleic Acid (mRNA) vaccine candidate, evaluate its immunogenicity using the hemagglutination inhibition assay, Enzyme-Linked Immunosorbent Assay (ELISA), and assess its efficacy in animals. We demonstrate the higher immunogenicity of the messenger Ribonucleic Acid (mRNA) vaccine candidate compared to the inactivated split influenza vaccine and its enhanced ability to generate a cross-specific humoral immune response. These findings highlight the potential messenger Ribonucleic Acid (mRNA) technology in overcoming current limitations of influenza vaccines and hold promise for ensuring greater efficacy in preventing seasonal influenza outbreaks | Mazunina Elena P; Gushchin Vladimir A; Kleymenov Denis A; Siniavin Andrei E; Burtseva Elena I; Shmarov Maksim M; Mukasheva Evgenya A; Bykonia Evgeniia N; Kozlova Sofia R; Evgrafova Elina A; Zolotar Anastasia N; Shidlovskaya Elena V; Kirillova Elena S; Krepkaia Anastasiya S; Usachev Evgeny V; Kuznetsova Nadezhda A; Ivanov Igor A; Dmitriev Sergey E; Ivanov Roman A; Logunov Denis Y; Gintsburg Alexander L | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in immunology | 38690262 | Critical role of G3BP1 in bovine parainfluenza virus type 3 (BPIV3)-inhibition of stress granules formation and viral replication. | It remains unclear whether BPIV3 infection leads to stress granules formation and whether G3BP1 plays a role in this process and in viral replication. This study aims to clarify the association between BPIV3 and stress granules, explore the effect of G3BP1 on BPIV3 replication, and provide significant insights into the mechanisms by which BPIV3 evades the host's antiviral immunity to support its own survival | Liu Nian; Yang Wei; Luo Lingzhi; Ma Mingshuang; Cui Jin; Dong Xiumei; Li Yijing | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in immunology | 38690261 | Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives. | Extracellular vesicles (EVs) are important cell-to-cell communication mediators. This paper focuses on the regulatory role of tumor-derived EVs on macrophages. It aims to investigate the causes of tumor progression and therapeutic directions. Tumor-derived EVs can cause macrophages to shift to M1 or M2 phenotypes. This indicates they can alter the M1/M2 cell ratio and have pro-tumor and anti-inflammatory effects. This paper discusses several key points: first, the factors that stimulate macrophage polarization and the cytokines released as a result; second, an overview of EVs and the methods used to isolate them; third, how EVs from various cancer cell sources, such as hepatocellular carcinoma, colorectal carcinoma, lung carcinoma, breast carcinoma, and glioblastoma cell sources carcinoma, promote tumor development by inducing M2 polarization in macrophages; and fourth, how EVs from breast carcinoma, pancreatic carcinoma, lungs carcinoma, and glioblastoma cell sources carcinoma also contribute to tumor development by promoting M2 polarization in macrophages. Modified or sourced EVs from breast, pancreatic, and colorectal cancer can repolarize M2 to M1 macrophages. This exhibits anti-tumor activities and offers novel approaches for tumor treatment. Therefore, we discovered that macrophage polarization to either M1 or M2 phenotypes can regulate tumor development. This is based on the description of altering macrophage phenotypes by vesicle contents | Wang Lijuan; Wang Weihua; Hu Die; Liang Yan; Liu Zhanyu; Zhong Tianyu; Wang Xiaoling | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | National journal of maxillofacial surgery | 38690255 | Guidelines for dental implants in the times of COVID-19. | Since the first reported case in December 2019, COVID-19 has become a worldwide pandemic. Although primarily a zoonotic infection, human-to-human transmission is well reported now and the mode of spread is mainly via respiratory droplets during direct contact or via surfaces contaminated with the virus as it remains viable on the surfaces for a long time. Direct communication and consistent exposure to body fluids such as blood and saliva and the fact that routinely done dental procedures generate aerosols predisposing dental professionals to serious risk for COVID-19 infection. Hence, to ensure the smooth working and safety of dental professionals as well as the patients, a set of directives are of paramount importance. Various guidelines have been released for the efficient operation of dental professionals; however, no such recommendations/directives have been laid out pertaining to dental implants in particular. Here, we are presenting a set of recommendations for managing urgent implant-related treatment procedures | Solanki Neeti; Yadav Lakshya Kumar; Singh Mayank; Chand Pooran | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | National journal of maxillofacial surgery | 38690254 | Evaluation of the non-endoscopic and endoscopic-assisted platysma flap - A randomized control trial. | As oral submucous fibrosis (OSMF) is a chronic progressive disorder, the treatment is based on the severity of the disease. Surgical treatment is the only choice for grade III and grade IV OSMF cases because the patient can neither clean his/her mouth nor properly chew. The resulting soft tissue defect requires resurfacing with various well-vascularized tissues such as extraoral flaps, intraoral flaps, microvascular flaps, and allografts that have been used. Reconstruction of the resultant defects proved to be challenging. Till date, none of the flaps has been proven to be effective and is universally accepted for the treatment of OSMF because of various drawbacks of the available techniques. This study was conducted to know whether an endoscopic-assisted platysma flap is associated with better outcomes in terms of ease of operation and postoperative function than the conventional approach | Kumar Sandeep; Pal Uma Shanker; Mohammad Shadab; Singh Vibha; Kumar Vijay; Agrawal Amiya; Singh Aastha | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | National journal of maxillofacial surgery | 38690250 | Comparative efficacy of pre-operative and post-operative administration of amoxicillin in third molar extraction surgery - A systematic review and meta-analysis. | To compare the effectiveness of pre-operative and post-operative administration of amoxicillin in patients undergoing third molar extraction surgery. A systematic search was executed according to PRISMA guidelines for studies published till December 2021. Studies were included based on the pre-eligibility criteria. The risk of bias was assessed using the Cochrane risk of bias tool. The heterogeneity was evaluated, and a random effect model was used for meta-analysis. A total of five studies were included from an initial search of 96 studies. The included studies were randomized controlled trials and comparative studies assessing pre-operative and post-operative administration of antibiotics among patients undergoing third molar extraction surgery. For comparison between pre-operative and post-operative groups, interincisal distance, complications, pain, and swelling were systematically reviewed and meta-analysis was done for interincisal distance and complications. The mean change in interincisal distance ranged from 5.5 to 47.9 and from 4.56 to 46.1 in the pre-operative and post-operative amoxicillin groups, respectively. Complications reported were infections, alveolar osteitis, nausea, diarrhea, gastric pain, rash, and headache with a pooled incidence of 4.3-33% in the pre-operative amoxicillin group and 0-22.7% in the post-operative amoxicillin group. Quantitative synthesis of data carried out from meta-analysis shows a significant difference in the pre-operative and post-operative amoxicillin groups in improving the interincisal distance and incidence of complications post surgery. The qualitative synthesis of data derived from systematic review for pain provides favoring results for post-operative amoxicillin administration. In case of swelling, a non-conclusive result was obtained | Karemore Tapasya V; Ashtankar Kanchan A; Motwani Mukta | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | National journal of maxillofacial surgery | 38690248 | Interim management of Pierre Robin sequence using a custom-made face mask. | Pierre Robin sequence poses a great challenge for anesthesiologists during laryngoscopy and intubation, making oxygenation and ventilation difficult. The role of early surgical intervention is recommended for the improvement of the airway and overall survival of the neonate. The situation becomes even more challenging, when the neonate may not be fit for such surgical interventions. The present case posed such a challenge to the team. To the authors' knowledge, the decision to use a face mask as an interim life-saving measure was considered for the first time. This provided a greater window of opportunity for further course of action, only to be later managed by distraction osteogenesis of the mandible. The unconventional use of orthopedic appliances for the management of threatened airways may provide the clinician with time, where further management may be carried out. The present article will explain such a procedure that was carried out as a life-saving measure | Kulkarni Vishal; Senthil Kumar C; Rath Mukti K; Singh Madhu | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | National journal of maxillofacial surgery | 38690244 | A clinic-pathological research explored the significance of ascorbic acid and iron levels in serum and saliva in premalignant disorder patients at Kanpur, Uttar Pradesh. | Oral submucous fibrosis (OSMF), or OSMF, is a well-known, potentially premalignant condition of the oral cavity. Monitoring OSMF widespread effects necessitate interventions in at-risk individuals, ideally before the disease becomes aggressive. Ascorbic acid and iron, for instance, are significant micronutrients in the pathogenesis of OSMF | Sachdev Rohan; Garg Kriti; Mehrotra Vishal; Shwetam Samiksha; Singh Praveen; Srivastava Akash | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | National journal of maxillofacial surgery | 38690241 | Fabrication of orbital prosthesis by two different methods in patients with post-COVID-19 rhino-orbital maxillary mucormycosis: A case series. | Neoplasms, congenital disorders, fungal infections, and traumatic injuries are the predominant causes of orbital defects. Various retentive mechanisms such as application of adhesive, utilization of mechanical undercuts, and implant-supported attachments are generally used in the maxillofacial prosthesis. In the orbital region, the result of magnet-retained attachments is favorable compared with other mechanisms. Different advantages of the magnet-retained prosthesis are less manual dexterity needed during insertion or removal and better maintenance of hygiene. The skin-implant interface and thick tissues in the maxillofacial region are the critically important points that should be given importance during the planning and placement of implants. Ideally, implant sites for orbital prosthesis are the lateral, infra-, and supraorbital rims of the orbital region. The following case series describes two different methods to rehabilitate patients with an exenterated eye due to mucormycosis by individually designed implant with magnetic attachment and mechanical undercut-retained orbital prosthesis | Bhattacharjee Bappaditya; Srivastava Roopal; Bansal Rajesh; Sharma Naresh K | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | National journal of maxillofacial surgery | 38690233 | Assessment of neurovascular channels in lateral maxillary sinus wall using cone-beam computed tomography: An imperative clinicians guide for implant placements. | The aim of this study is to evaluate the location and radio morphometric features of the posterior superior alveolar artery (PSAA) in patients undergoing rehabilitation of posterior maxilla and other sinus augmentation surgical procedures by cone-beam computed tomography (CBCT) | Rai Shalu; Misra Deepankar; Misra Akansha; Jain Ankit; Dabas Priyanka; Ali Qaiser; Kumar Manish | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in psychiatry | 38690205 | Stalking, harassment, gendered abuse, and violence towards politicians in the COVID-19 pandemic and recovery era. | High levels of harassment and threats against parliamentarians are being reported internationally, especially in the social media space. This is occurring alongside changes in our social landscape, with increasing political polarisation and the ongoing ramifications from the COVID-19 pandemic. Harassment of politicians has been shown to have implications for psychological wellbeing and physical safety | Every-Palmer Susanna; Hansby Oliver; Barry-Walsh Justin | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in psychiatry | 38690202 | Machine learning models predict the emergence of depression in Argentinean college students during periods of COVID-19 quarantine. | The COVID-19 pandemic has exacerbated mental health challenges, particularly depression among college students. Detecting at-risk students early is crucial but remains challenging, particularly in developing countries. Utilizing data-driven predictive models presents a viable solution to address this pressing need | López Steinmetz Lorena Cecilia; Sison Margarita; Zhumagambetov Rustam; Godoy Juan Carlos; Haufe Stefan | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in psychiatry | 38690200 | Becoming a first-time father during the COVID-19 pandemic in France. | The role of fathers in Western societies has undergone significant change over time. However, their psychopathology remains largely misunderstood and difficult to identify. This study aims to explore the lived experiences of first-time fathers during the COVID-19 pandemic. Twenty-seven first-time French fathers were recruited for the study, which involved a narrative interview, the Rorschach projective test, the Edinburgh Postnatal Depression Scale (EPDS), and a semi-structured interview. Narrative interviews revealed several challenges faced by these fathers, including the pressure of paternal responsibility, the need to be actively involved in the prenatal activities and caregiving (haptonomy, skin-to-skin contact), and concerns about the future of their couple and family as a triad. The Rorschach tests showed numerous perinatal responses and difficulties in identifying phallic representations among the fathers. Additionally, the EPDS scores indicated that 15% of fathers showed signs of depression, while 52% exhibited signs of anxiety. This study also examines the impact of the COVID-19 pandemic and its associated health context on creating the initial triad. Lastly, the case of one father is presented to illustrate the need for diagnostic tools to address the psychopathology of fathers, as narrative or semi-structured interviews have often fallen short of addressing this issue | Jean-Dit-Pannel Romuald; Belot Rose-Angélique; Mellier Denis; Robert Laura; Petersen Célia; Dinet Benoît; Bréhat Cécile; Koliouli Flora | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine | 38690183 | Impact of frailty on long-term survival in patients discharged alive from hospital after an ICU admission with COVID-19. | Though frailty is associated with mortality, its impact on long-term survival after an Intensive Care Unit (ICU) admission with COVID-19 is unclear. We aimed to investigate the association between frailty and long-term survival in patients after an Intensive Care Unit (ICU) admission with COVID-19 | Subramaniam Ashwin; Ling Ryan Ruiyang; Pilcher David | 2024-01-03 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in oncology | 38690167 | Case report: Acquired resistance to crizotinib from a MET Y1230H mutation in a patient with non-small cell lung cancer and | The c-met proto-oncogene ( | Dong Su-Su; Dong Wen; Tan Ya-Fen; Xiao Qiang; Wang Tian-Li | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in oncology | 38690166 | Advancements and trends in exosome research in lung cancer from a bibliometric analysis (2004-2023). | Lung cancer, characterized by its high morbidity and lethality, necessitates thorough research to enhance our understanding of its pathogenesis and discover novel therapeutic approaches. Recent studies increasingly demonstrate that lung cancer cells can modulate the tumor microenvironment, promoting tumor growth, and metastasis through the release of exosomes. Exosomes are small vesicles secreted by cells and contain a variety of bioactive molecules such as proteins, nucleic acids, and metabolites. This paper presents a comprehensive review of exosome research in lung cancer and its progress through bibliometric analysis | Zhong Wen; Zhao Xiaofei; Zhang Xiabiao; Xu Yiwen; Liu Mengqian; Yang Xiaoyun; Jiang Yi; Shen Xiaozhu | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Journal of multidisciplinary healthcare | 38690156 | The Impact of the COVID-19 Pandemic on Orthodontic Adult Patients' Characteristics and Decision on Orthodontic Appliance. | There is an overall paucity of data examining the specific details of orthodontic patients' patterns or orthodontic service disruptions possibly influenced by COVID-19 pandemic. Therefore, this study aimed to explore the impact of the COVID-19 pandemic on orthodontic clinic disruption regarding the change in adult patients' characteristics and decisions of orthodontic treatment devices | Kuo Yun-Yu; Fang Jason Chen-Chieh; Wang I-Kuan; Huang Chiung-Shing; Chen Hui-Ling; Yen Tzung-Hai | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Global health & medicine | 38690136 | Crisis management for the future: Building a platform to provide information on emerging and re-emerging infectious diseases from normal times in Japan. | At the beginning of the mpox (disease caused by monkey pox) epidemic, there was no platform in Japan to provide appropriate information on emerging and re-emerging infectious diseases (EIDs), and the number of accesses to bioterrorism-related information sites increased rapidly. Even though the interest in mpox was much smaller than in coronavirus infectious disease, emerged in late 2019 (COVID-19), the increase in the number of views were much greater than during the COVID-19 epidemic. This may not be because mpox is bioterrorism-related as an analog of smallpox, but rather because there were no other websites providing information on mpox. For future crisis management, there should be a platform to provide information on possible epidemics of EIDs from normal times in Japan | Adachi Eisuke; Otani Amato; Yotsuyanagi Hiroshi; Saijo Masayuki; Saito Tomoya | 2024-30-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Global health & medicine | 38690133 | Proposal to apply a "Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment (PERMA)" based approach to manage the COVID-19-related mental health problems in the era of long COVID. | Long COVID (LC)-related health problems are highly concerned. Many patients seem to have "recovered" from an acute Severe Acute Respiratory Syndrome (SARS)-CoV-2 infection, however, they might experience various symptoms, almost involving all organs and systems. Of those, neuropsychiatric symptoms like depression, anxiety, and post-traumatic stress disorder (PTSD) are not rare. These problems significantly impact the quality of life (QOL) of patients, family, and caregivers, even lead a tragic suicide outcome. Other than the conventional psychological and medical approaches, here, we proposal a positive emotion, engagement, relationships, meaning, and accomplishment (PERMA)-based approach to fight against these COVID-19-related mental health problems (CRMHPs). This approach is characterized by positive psychological interventions and self-achievements, which has been proved to be a powerful tool against mood disorders in common people. Nowadays, abolishment of certain prophylactic measures (such as isolation, lockdown, compulsorily wearing a mask and maintaining social distance, measures to avoid crowding) enables us to have more opportunities to contact patients and implement the PERMA-based approach to the patients with CRMHPs. We believe that application of PERMA-based approach is conducive to alleviate the influence of the CRMHPs and improve their QOL | Sun Kai; Zhou Rongfeng; Xu Fang; Lu Hongzhou; Asakawa Tetsuya | 2024-30-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Global health & medicine | 38690131 | Developments and current challenges in the process of cell culture-based seasonal influenza vaccine manufacture in Japan. | Seasonal influenza is an acute respiratory infection primarily caused by influenza A and B viruses, which circulate annually and cause substantial morbidity and mortality worldwide. Annual influenza vaccination is currently the most effective measure for preventing influenza and greatly reduces the risk of disease severity and the incidence of complications and death. Annual seasonal influenza vaccines are traditionally produced in Japan and many other countries using viruses propagated in embryonated chicken eggs. However, at present, the effectiveness of the seasonal influenza vaccines has some significant limitations, partly because of egg-adaptive mutations in the antigenic sites of the influenza virus haemagglutinin, which are caused by the continued evolution of seasonal influenza viruses. To overcome the limitations of egg-based influenza vaccine production, a mammalian cell culture-based influenza vaccine production system has been developed in Japan in the past decade as an alternative to the current production method. In this review, I have summarised the progress in the development of cell-based seasonal influenza vaccines and discussed the technological challenges encountered in the development of influenza vaccines | Hamamoto Itsuki | 2024-30-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | JBMR plus | 38690127 | Collagen mutation and age contribute to differential craniofacial phenotypes in mouse models of osteogenesis imperfecta. | Craniofacial and dentoalveolar abnormalities are present in all types of osteogenesis imperfecta (OI). Mouse models of the disorder are critical to understand these abnormalities and underlying OI pathogenesis. Previous studies on severely affected OI mice report a broad spectrum of craniofacial phenotypes, exhibiting some similarities to the human disorder. The Brtl/+ and G610c/+ are moderately severe and mild-type IV OI, respectively. Little is known about the aging effects on the craniofacial bones of these models and their homology to human OI. This study aimed to analyze the Brtl/+ and G610c/+ craniofacial morphometries during aging to establish suitability for further OI craniofacial bone intervention studies. We performed morphological measurements on the micro-Computed Tomography (CT)-scanned heads of 3-wk-old, 3-mo-old, and 6-mo-old female Brtl/+ and G610c/+ mice. We observed that Brtl/+ skulls are shorter in length than WT ( | Sung Hsiao H; Spresser Wyatt J; Hoffmann Joseph P; Dai Zongrui; Van der Kraan Peter M; Caird Michelle S; Davidson Esmeralda Blaney; Kozloff Kenneth M | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Oncology letters | 38690101 | Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report. | Pulmonary adenocarcinoma with breast metastasis is rarely encountered in clinical practice. Therefore, precise clinical diagnosis of patients with this disease is crucial when selecting subsequent treatment modalities and for overall prognosis assessment. The present study reported on a case of lung cancer with breast metastasis harboring the | Zhang Wenwen; Zhang Yu; Zhou Lei; Tan Na; Bai Yuju; Xing Shiyun | 2024-01-06 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Arthroplasty today | 38690096 | The Impact of the Coronavirus Disease 2019 Pandemic on US Total Knee and Hip Arthroplasty Procedures in 2020. | The coronoavirus disease 2019 (COVID-19) pandemic had profound impact on elective procedures in the United States. We characterized the longer-term decline and recovery of hip and knee arthroplasty procedures following the onset of the COVID-19 pandemic in the United States | Barnes Matthew R; Zagaria Alexandra B; Werth Paul M; Jevsevar David S | 2024-01-06 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Case reports in neurology | 38690082 | Survival from Rhino-Orbital-Cerebral Mucormycosis in SARS-CoV-2-Positive Diabetic Patients: Two Case Reports. | Rhino-orbital-cerebral mucormycosis (ROCM) is a rare angioinvasive fungal infection known to be associated with high morbidity and over 50% mortality. ROCM is becoming more common due to an increase in predisposing immunocompromising comorbidities as well as COVID-19 | Lädrach Claudia; Wartenberg Martin; Zimmerli Stefan; Anschuetz Lukas; Bohlen Stefan; Ebner Julian; de Gouyon Matignon de Pontouraude Claire M F; Caversaccio Marco; Wagner Franca | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Respirology case reports | 38690063 | Tracheobronchomalacia following allogeneic haematopoietic stem cell transplantation. | Tracheobronchomalacia (TBM) occurs due to the weakening of cartilaginous part of the trachea, resulting in compromised airway function and leading to symptoms such as dyspnea, cough, and inability to clear secretions. Bronchiolitis obliterans syndrome (BOS) is the most prevalent late noninfectious pulmonary complication in patients who underwent allogeneic haematopoietic stem cell transplantation (HSCT). Therefore, patients experiencing progressive dyspnea and chronic cough after allogenic HSCT, with new obstructive pattern on pulmonary function test, are typically diagnosed with post-transplant BOS. However, it is important to note that TBM can also manifest as an obstructive defect pattern on pulmonary function test. Tracheomalacia has been reported as a rare complication of allogenic stem cell transplantation. We present two patients who developed TBM following allogeneic HSCT and were initially treated for post-transplant BOS but did not experience symptom improvement. However, after treatment with continuous positive airway pressure, their symptom subsided | Panpruang Pitirat; Eksombatchai Dararat; Boonsarngsuk Viboon | 2024-01-05 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | World journal of gastrointestinal surgery | 38690053 | Blastomas of the digestive system in adults: A review. | Blastomas, characterized by a mixture of mesenchymal, epithelial, and undifferentiated blastematous components, are rare malignant neoplasms originating from precursor blast cells. This review focuses on digestive system blastomas in adult patients, including gastroblastoma, hepatoblastoma, and pancreatoblastoma. Gastroblastoma is a biphasic, epitheliomesenchymal tumor, with only sixteen cases reported to date. In addition to the characteristic histology, metastasis-associated lung adenocarcinoma transcript 1 - glioma-associated oncogene homolog 1 gene fusion is typical, although recently novel ewing sarcoma breakpoint region 1 - c-terminal binding protein 1 and patched 1 - glioma-associated oncogene homolog 2 fusions have been described. Hepatoblastoma is exceptionally rare in adults and can show a variety of histologic patterns which may cause diagnostic difficulty. Pancreatoblastoma, primarily a pediatric tumor, displays acinar differentiation and squamoid nests with other lines of differentiation also present, especially neuroendocrine. Diagnostic approaches for these blastomas include a combination of imaging modalities, histopathological examination, and molecular profiling. The treatment generally involves surgical resection, which may be supplemented by chemotherapy or radiotherapy in some cases. Prognoses vary with gastroblastoma generally showing favorable outcomes post-surgery whereas hepatoblastoma and pancreatoblastoma often have poorer outcomes, particularly in the setting of metastases. This review highlights the complexity of diagnosing and managing these rare adult blastomas as well as the need for ongoing research to better understand their pathogenesis and improve treatment strategies | Liu Yu; El Jabbour Tony; Somma Jonathan; Nakanishi Yukihiro; Ligato Saverio; Lee Hwajeong; Fu Zhi-Yan | 2024-27-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Heliyon | 38690000 | Distinguishing optimal candidates for primary tumor resection in patients with metastatic lung adenocarcinoma: A predictive model based on propensity score matching. | Primary tumor resection is associated with survival benefits in patients with metastatic lung adenocarcinoma (mLUAD). However, there are no established methods to determine which individuals would benefit from surgery. Therefore, we developed a model to predict the patients who are likely to benefit from surgery in terms of survival | Qi Yuying; Guo Xiaojin; Li Zijie; Ren Bingzhang; Wang Zhiyu | 2024-15-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Heliyon | 38689973 | L-Thyroxine and L-thyroxine-based antimicrobials against Streptococcus pneumoniae and other Gram-positive bacteria. | The rise of antibiotic-resistant | Galano-Frutos Juan José; Maity Ritwik; Iguarbe Verónica; Aínsa José Antonio; Velázquez-Campoy Adrián; Schaible Ulrich E; Mamat Uwe; Sancho Javier | 2024-15-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Heliyon | 38689964 | HIF1A-dependent overexpression of MTFP1 promotes lung squamous cell carcinoma development by activating the glycolysis pathway. | Mitochondrial fission process 1 ( | Ji Jing; Wang Yasong; Jing Aixin; Ma Ling; Yang Jiayan; Ren Dexu; Lv Jinyu; Lv Mingxiao; Xu Menghan; Yuan Qing; Ma Xinhui; Qian Qilan; Wang Weiling; Geng Ting; Ding Yuanyuan; Qin Jingting; Liu Yuanyuan; Zhou Jiaojiao; Zuo Lingyi; Ma Shaojie; Wang Xiujun; Liu Bin | 2024-15-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Heliyon | 38689951 | Spurring SMEs' performance through business intelligence, organizational and network learning, customer value anticipation, and innovation - Empirical evidence of the creative economy sector in East Java, Indonesia. | Several studies have explored firm performance in the post-Covid-19 pandemic era. However, there is not much research to find reports divulging the complex relationship dynamics between business intelligence, organizational and network learning, customer value anticipation, and creative economy-based small-medium enterprises (SMEs) performance in developing countries. This study aims to uncover the complexity of those relationships. The quantitative data were collected from 313 creative economy-based SMEs in East Java, Indonesia. Using PLS-SEM, this study disclosed that business intelligence practices could not directly impact SMEs' performance. Business intelligence will be crucial to SMEs' performance with the support of organizational learning as a mediator. The finding also confirmed the presence of serial mediation of organizational learning and innovation in the relationship between business intelligence and SMEs' performance. However, the role of network learning and innovation is also important, considering their relatively large direct impact on SMEs' performance. The theoretical implications of this research broke the boundaries of strategic management theory in resource-based view and knowledge-based view in the latest era, where creative economy-based SMEs have been able to mobilize resources to carry out business intelligence to realize innovation and high performance. Further research is suggested to explore the role of business intelligence in promoting specific performance areas, such as marketing performance, financial performance, and human resource management. In addition, it is advisable to choose more specific research subjects, including those in the culinary subsector, and pay attention to other areas, e.g., the demographics of respondents in the model as a control variable | Anjaningrum Widiya Dewi; Azizah Nur; Suryadi Nanang | 2024-15-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | MedEdPublish (2016) | 38689938 | Medical education in Bangladesh from Student and Teacher's Perspective: Impact and challenges of the COVID-19 pandemic. | In low- and middle-income countries like Bangladesh, where medical education faces a range of challenges-such as lack of infrastructure, well-trained educators, and advanced technologies, abrupt changes in methodologies without adequate preparation are more challenging than in higher-income countries. This was worsened during the COVID-19 pandemic and these challenges have resulted in a change in medical education methodology. This study assesses the medical education procedure, impacts and adaptation strategies and challenges of the COVID-19 pandemic in the medical education system of Bangladesh from learners' as well as educators' perspectives | Rahman M Wakilur; Hasan Md Mahfuzul; Palash Md Salauddin; Asaduzzaman Md | 2023-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in nutrition | 38689936 | Exploring food system resilience to the global polycrisis in six Asian countries. | The world is currently in the midst of a global food crisis brought about and exacerbated by a series of mutually reinforcing shocks to food systems This study investigated the resilience of food systems in six Asian countries (Bangladesh, Kyrgyz Republic, Lao PDR, Pakistan, Philippines, and Sri Lanka) amidst the global 'polycrisis' caused by COVID-19, geopolitical conflicts, and climate change. Trend analyses were performed for 19 indicators sourced from global databases and World Food Programme national data, representing the four domains of food system resilience: exposure to shocks; resilience capacities and agro- and food diversity, resilience responses and strategies; and long-term resilience outcomes. The analysis revealed that all six countries experienced the effects of the 'polycrisis', leading to diverse impacts on exchange rates, with Sri Lanka, Pakistan, and Lao PDR facing significant currency depreciation. While most countries increased crop production and decreased food imports during the crisis, government economic support during the pandemic varied widely. Resilience outcomes, including national food price inflation and the proportion of populations facing food insecurity, witnessed upward variations. Overall, countries with higher resilience capacities at the start of the 'polycrisis' showed less severe long-term resilience outcomes. Our findings highlight the varied challenges and resilience capacities across each country, influenced by a complex interplay of economic, political, agricultural, and food affordability factors crucial for determining long-term resilience in their food systems. Recommendations for future research include focusing on resilience assessment in food systems, integrating climate change adaptation measures, and developing early intervention strategies | Favas Caroline; Cresta Chiara; Whelan Elizabeth; Smith Kristie; Manger Mari S; Chandrasenage Damith; Singhkumarwong Anusara; Kawasaki Jintana; Moreno Susana; Goudet Sophie | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | 3D printing and additive manufacturing | 38689930 | Synthesis and Investigation of Mechanical Properties of the Acrylonitrile Butadiene Styrene Fiber Composites Using Fused Deposition Modeling. | Additive manufacturing is becoming a global phenomenon due to its versatile properties and numerous benefits, which is not possible by conventional machining processes. Fused deposition modeling (FDM) shows a huge potential of shift from rapid prototyping toward the rapid manufacturing. Nowadays, the strength of the FDM-printed parts is very important to consider along with all the printing parameters, which affect the strength of these parts. This study includes the investigation of printing parameters (infill density, layer thickness, and shell count) on the strength of FDM-printed parts of acrylonitrile butadiene styrene (ABS) and carbon fiber-reinforced ABS (ABS-Cystic Fibrosis (CF)). These printing parameters directly affect the quality as well as the strength of the 3D-printed parts through FDM. Tensile tests were performed on the universal testing machine on both types of printed parts. The optimized parameters for the 3D-printed samples of the pristine ABS are found to be 0.1045 mm of layer thickness, 57.72% of infill density, and 7.63 numbers of shell count, while the optimum parameters obtained for ABS-Cystic Fibrosis (CF) are 0.2780 mm of layer thickness, 28.37% of infill density, and 9.88 numbers of shell count. The results show that the layer thickness and shell count have a significant effect on the ultimate tensile strength of the 3D-printed parts | Zahid Ali; Anwar Muhammad Tuoqeer; Ahmed Arslan; Raza Yasir; Gohar Ghulam Abbas; Jamshaid Muhammad | 2024-01-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Preventive medicine reports | 38689887 | Short Communication: Radon testing via a state tobacco quitline. | Exposure to radon gas at home is the second largest cause of lung cancer after smoking and dramatically increases smokers' risk of lung cancer. State tobacco quitlines are uniquely positioned to inform smokers about radon, yet, to our knowledge, none does so. We explored the feasibility of introducing free radon tests via the tobacco quitline in North Dakota, a state with one of the highest radon levels in the U.S | Schmitz David; Klug Marilyn G; Schwartz Gary G | 2024-01-06 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in cardiovascular medicine | 38689861 | Atrial fibrillation and COVID-19: an analysis of the ambulatory database. | Atrial fibrillation (AF) is the most common heart rhythm disorder in clinical practice. It worsens the quality of life of patients, leads to an increase in the mortality rate because of its association with a high risk of thromboembolic complications. The current pandemic of a new coronavirus infection, which began in March 2020, was marked by an increase in cardiovascular diseases, including an increase in the number of patients with AF. That is why it is extremely relevant to find answers to questions about the association and mutual influence of AF and coronavirus infection to reduce the risk of vascular complications. However, most research in this area has focused on hospital patients. In this study, an electronic database of outpatients with AF, including patients with a history of COVID-19 infection was analyzed in order to assess the most significant risk factors for complications | Sizova Zhanna M; Zakharova Valeria L; Shindryaeva Natalya N; Lapidus Natalia I; Melnik Mariya V; Shikh Evgenia V; Grebenshchikova Ludmila Y; Beloborodova Alexandra V; Polovikov Ivan P | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Infectious Disease Modelling | 38689855 | An SEIHR model with age group and social contact for analysis of Fuzhou COVID-19 large wave. | The structure of age groups and social contacts of the total population influenced infection scales and hospital-bed requirements, especially influenced severe infections and deaths during the global prevalence of COVID-19. Before the end of the year 2022, Chinese government implemented the national vaccination and had built the herd immunity cross the country, and announced Twenty Measures (November 11) and Ten New Measures (December 7) for further modifications of dynamic zero-COVID polity on the Chinese mainland. With the nation-wide vaccination and modified measures background, Fuzhou COVID-19 large wave (November 19, 2022-February 9, 2023) led by Omicron BA.5.2 variant was recorded and prevailed for three months in Fujian Province | Lan Xiaomin; Chen Guangmin; Zhou Ruiyang; Zheng Kuicheng; Cai Shaojian; Wei Fengying; Jin Zhen; Mao Xuerong | 2024-01-09 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Infectious Disease Modelling | 38689854 | Mathematical modeling for estimating influenza vaccine efficacy: A case study of the Valencian Community, Spain. | Vaccine efficacy and its quantification is a crucial concept for the proper design of public health vaccination policies. In this work we proposed a mathematical model to estimate the efficacy of the influenza vaccine in a real-word scenario. In particular, our model is a SEIR-type epidemiological model, which distinguishes vaccinated and unvaccinated populations. Mathematically, its dynamics is governed by a nonlinear system of ordinary differential equations, where the non-linearity arises from the effective contacts between susceptible and infected individuals. Two key aspects of this study is that we use a vaccine distribution over time that is based on real data specific to the elderly people in the Valencian Community and the calibration process takes into account that over one influenza season a specific proportion of the population becomes infected with influenza. To consider the effectiveness of the vaccine, the model incorporates a parameter, the vaccine attenuation factor, which is related with the vaccine efficacy against the influenza virus. With this framework, in order to calibrate the model parameters and to obtain an influenza vaccine efficacy estimation, we considered the 2016-2017 influenza season in the Valencian Community, Spain, using the influenza reported cases of vaccinated and unvaccinated. In order to ensure the model identifiability, we choose to deterministically calibrate the parameters for different scenarios and we find the one with the minimum error in order to determine the vaccine efficacy. The calibration results suggest that the influenza vaccine developed for 2016-2017 influenza season has an efficacy of approximately 76.7%, and that the risk of becoming infected is five times higher for an unvaccinated individual in comparison with a vaccinated one. This estimation partially agrees with some previous studies related to the influenza vaccine. This study presents a new integrated mathematical approach to study the influenza vaccine efficacy and gives further insight into this important public health topic | Andreu-Vilarroig Carlos; Villanueva Rafael J; González-Parra Gilberto | 2024-01-09 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Contemporary clinical trials communications | 38689829 | A randomised clinical trial of awake prone positioning in COVID-19 suspects with acute hypoxemic respiratory failure. | Awake prone position (APP) has been reported to improve oxygenation in patients with COVID-19 disease and to reduce the requirement for invasive mechanical ventilation for patients requiring support with high flow nasal cannula. There is conflicting data for patients requiring lower-level oxygen support | Harris Tim R E; Bhutta Zain A; Qureshi Isma; Kharma Nadir; Raza Tasleem; Hssain Ali Ait; Pathare Ankush Suresh; D'Silva Ashwin; Khatib Mohamad Yahya; Mohamedali Mohamed Gafar Hussein; Macineira Ignacio Miguel Gomez; Garcia Hernandez Victor Ramon; Garcia Jorge Rosales; Thomas Stephen H; Pathan Sameer A | 2024-01-06 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Archive of clinical cases | 38689819 | Recurrent diffuse alveolar hemorrhage and extracorporeal membrane oxygenation utilization in a hematopoietic stem cell transplant patient with Hunter's syndrome. | We describe the natural history of a three-month-old patient with Hunter Syndrome with hematopoietic stem cell transplant (HSCT) who developed recurrent diffuse alveolar hemorrhage (DAH) requiring extracorporeal membrane oxygenation (ECMO). The patient underwent HSCT with several complications, including veno-occlusive disease and DAH. He was managed with ECMO. Unfortunately, despite initial success he developed recurrent DAH and ultimately died. This is a novel report of this severe adverse event requiring ECMO following the use of HSCT in this rare patient population. We share the clinical strategies employed to address the complications associated with HSCT and the progression of his disease over his hospitalization | Noor Nasreen; Peir Gene; Wagner Ásdís Finnsdóttir; Rilinger Jay; Miller Jenna | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Radiology case reports | 38689808 | Extrinsic compression of left main coronary artery due to pulmonary artery aneurysm and pulmonary hypertension. | Idiopathic pulmonary arterial hypertension is a serious condition that carries a poor prognosis. While exertional dyspnea is the most common symptom, angina like chest pain, most often due to right ventricle ischemia, may occur at advanced stages. We present a patient with pulmonary hypertension symptomatic for dyspnea and angina in whom computed coronary tomography angiography showed compression of the left main coronary artery by a large pulmonary artery aneurysm. Percutaneous coronary intervention and stenting was performed resulting in significant clinical improvement. This case emphasizes the role of different cardiovascular imaging modalities for the diagnosis of rare conditions | Dallapé de la Reta Nicolás; Oscos Martín; Pedroni Pablo; Giachello Federico; Hauqui Agustín; Scaglia Juan; Grinfeld Diego; Acevedo Ramiro; Sarmiento Ricardo; Solernó Raúl | 2024-01-07 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Radiology case reports | 38689807 | Two cases of vertebral perfusion disturbances in computer tomography imitating metastatic lesions in the course of superior vena cava thrombosis. | Skeletal metastases are frequently observed in various malignancies. In some cases, they are asymptomatic and can be found incidentally in various imaging methods in patients without known malignant tumors. In this case study 2 cases of vertebral perfusion disturbances are presented that imitate vertebral metastatic lesions in computer tomography in the course of superior vena cava thrombosis. The first patient was referred to our clinic for chest and abdominal computer tomography (Computed Tomography (CT)) for staging due to a known tumor in the anterior mediastinum. The second patient was referred for chest Computed Tomography (CT) due to swelling in the upper extremity and neck, with the suspected diagnosis of a tumor or pulmonary embolism. In both cases, Computed Tomography (CT) scans showed metastases suspected lesions in the upper thoracic vertebral bodies. In both cases, additionally, the thrombosis of superior vena cava (SVC) and vena brachiocephalica was confirmed (in the first case due to tumor compression in the upper mediastinum, in the second case due to the presence of pacemaker leads). In control Computed Tomography (CT) scans after anticoagulation treatment, there were no suspected lesions in the vertebral bodies, which confirmed the diagnosis of vertebral perfusion disturbances in the course of SVC thrombosis in both patients. In conclusion, in rare cases of metastases suspected lesions of thoracic vertebral bodies in contrast-enhanced computer tomography among patients with a diagnosis of superior vena cava thrombosis vertebral perfusion disturbances should be included in differential diagnosis protocol | Gruszka Wojciech; Pietruschka Sascha A | 2024-01-07 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in public health | 38689777 | Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study. | Four years after the onset of the COVID-19 pandemic, the frequency of long-term post-COVID-19 cognitive symptoms is a matter of concern given the impact it may have on the work and quality of life of affected people | Bonfim Lívia Paula Freire; Correa Thais Rotsen; Freire Bruno Cabaleiro Cortizo; Pedroso Thais Marques; Pereira Daniella Nunes; Fernandes Thalita Baptisteli; Kopittke Luciane; de Oliveira Clara Rodrigues Alves; Teixeira Antonio Lucio; Marcolino Milena Soriano | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in public health | 38689776 | Analysis of care-seeking and diagnosis delay among pulmonary tuberculosis patients in Beijing, China. | Tuberculosis (Tuberculosis (TB)) remains a significant public health challenge in China. Early detection and diagnosis of Tuberculosis (TB) cases are crucial to interrupt disease transmission and prevent its progression. This study aims to describe the delay in seeking care and diagnosis among patients with pulmonary tuberculosis (PTB) and identify the influencing factors in two counties in Beijing | Zhang Lijie; Ma Xiaoge; Gao Hanqing; Bao Cheng; Wu Yue; Wu Sihui; Liu Menghan; Liu Yuhong; Li Liang | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in public health | 38689774 | Quality of life of patients with hip fracture was better during the COVID-19 period than before, an ancillary study from the HiFIT multicenter study. | The COVID-19 pandemic had a global impact on people life, notably because of lockdown periods. This could particularly affected patients suffering from hip fracture, who could have been more isolated during these periods. We aim at evaluating the impact of the COVID-19 period (including lockdown periods) on quality of life (QOL) in older adult patients 90 days after a surgery for a hip fracture | Lasocki Sigismond; Capdevila Xavier; Bijok Benjamin; Lahlou-Casulli Maria; Collange Vincent; Grillot Nicolas; Loupec Thibault; Rineau Emmanuel; Léger Maxime | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in public health | 38689771 | A systematic review of economic evaluations of pharmacological treatments for active tuberculosis. | The continuing spread of tuberculosis (Tuberculosis (TB)) worldwide, especially drug-resistant Tuberculosis (TB), poses a major challenge to healthcare systems globally. Addressing this requires appraising the cost effectiveness of existing pharmacological interventions against Tuberculosis (TB) to identify key drivers of cost effectiveness and value and guide pharmaceutical innovation and novel drug regimen development | Nagar Sarosh; Nicholls David; Dawoud Dalia | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | Frontiers in public health | 38689764 | Exploring behavioral intention to use telemedicine services post COVID-19: a cross sectional study in Saudi Arabia. | While telemedicine offers significant benefits, there remain substantial knowledge gaps in the literature, particularly regarding its use in Saudi Arabia. This study aims to explore health consumers' behavioral intention to use telemedicine examining the associated factors such as eHealth literacy and attitudes toward telemedicine services | Aldekhyyel Raniah N; Alshuaibi Faisal; Alsaaid Osama; Bin Moammar Faisal; Alanazy Talal; Namshah Abdulmajeed; Altassan Kholood; Aldekhyyel Reem; Jamal Amr | 2024-01-01 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | World journal of hepatology | 38689748 | Spectrum of COVID-19 induced liver injury: A review report. | The coronavirus disease 2019 (COVID-19) pandemic has caused changes in the global health system, causing significant setbacks in healthcare systems worldwide. This pandemic has also shown resilience, flexibility, and creativity in reacting to the tragedy. The severe acute respiratory syndrome coronavirus 2 (Severe Acute Respiratory Syndrome (SARS)-CoV-2) infection targets most of the respiratory tract, resulting in a severe sickness called acute respiratory distress syndrome that may be fatal in some individuals. Although the lung is the primary organ targeted by COVID-19 viruses, the clinical aspect of the disease is varied and ranges from asymptomatic to respiratory failure. However, due to an unorganized immune response and several affected mechanisms, the liver may also experience liver cell injury, ischemic liver dysfunction, and drug-induced liver injury, which can result in respiratory failure because of the immune system's disordered response and other compromised processes that can end in multisystem organ failure. Patients with liver cirrhosis or those who have impaired immune systems may be more likely than other groups to experience worse results from the Severe Acute Respiratory Syndrome (SARS)-CoV-2 infection. We thus intend to examine the pathogenesis, current therapy, and consequences of liver damage concerning COVID-19 | Singh Lokjan; Kumar Anil; Rai Maya; Basnet Bibek; Rai Nishant; Khanal Pukar; Lai Kok-Song; Cheng Wan-Hee; Asaad Ahmed Morad; Ansari Shamshul | 2024-27-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
PUBMED | World journal of hepatology | 38689745 | Quantitative hepatitis B core antibody and quantitative hepatitis B surface antigen: Novel viral biomarkers for chronic hepatitis B management. | The management of hepatitis B virus (HBV) infection now involves regular and appropriate monitoring of viral activity, disease progression, and treatment response. Traditional HBV infection biomarkers are limited in their ability to predict clinical outcomes or therapeutic effectiveness. Quantitation of HBV core antibodies (qAnti-HBc) is a novel non-invasive biomarker that may help with a variety of diagnostic issues. It was shown to correlate strongly with infection stages, hepatic inflammation and fibrosis, chronic infection exacerbations, and the presence of occult infection. Furthermore, qAnti-HBc levels were shown to be predictive of spontaneous or treatment-induced HBeAg and HBsAg seroclearance, relapse after medication termination, re-infection following liver transplantation, and viral reactivation in the presence of immunosuppression. qAnti-HBc, on the other hand, cannot be relied on as a single diagnostic test to address all problems, and its diagnostic and prognostic potential may be greatly increased when paired with qHBsAg. Commercial qAnti-HBc diagnostic kits are currently not widely available. Because many methodologies are only semi-quantitative, comparing data from various studies and defining universal cut-off values remains difficult. This review focuses on the clinical utility of qAnti-HBc and qHBsAg in chronic hepatitis B management | Leowattana Wattana; Leowattana Pathomthep; Leowattana Tawithep | 2024-27-04 | {'Introduction': '', 'Methodology': '', 'Findings': '', 'Discussion': '', 'Conclusion': '', 'Other Texts': ''} |
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