Patent Document

BACKGROUND OF THE INVENTION  
         [0001]    The present invention relates to an image processing method and apparatus, recording medium and imaging apparatus, and particularly to an image processing method and apparatus for adjusting pixel values constituting an image, a medium recorded with a program for causing a computer to implement such an image processing function, and an imaging apparatus comprising such an image processing apparatus.  
           [0002]    In a magnetic resonance imaging (MRI) apparatus, an object to be imaged is carried into an internal space of a magnet system, i.e., a space in which a static magnetic field is generated; gradient magnetic fields and a high frequency magnetic field is applied to cause spins within the object to generate magnetic resonance signals; and a tomographic image is produced based on the received signals.  
           [0003]    The effect of the gradient magnetic fields and high frequency magnetic field on the spins is different between the spins that move inside the body such as those in blood flow, and the spins that do not move such as those in a tissue. By using this difference, an image of the spins that move inside the body, i.e., for example, a blood flow image, may be captured.  
           [0004]    In capturing the blood flow image, a time-of-flight (TOF) technique, phase contrast (PC) technique or the like is employed.  
           [0005]    A blood flow projection image in a three-dimensional region is obtained by using one of these techniques to capture multi-slice blood flow tomographic images with respect to the three-dimensional region, and performing maximum intensity projection (MIP) on the multi-slice blood flow tomographic images in the slice thickness direction.  
           [0006]    When a projection image of blood flow is obtained as described above, faint blood flow may not be projected because it is obscured by noise. Moreover, when the average signal intensity of an image is different among slices, a blood flow image in an image with a small average signal intensity cannot be projected because it is obscured by noise in an image with a large average signal intensity.  
         SUMMARY OF THE INVENTION  
         [0007]    It is therefore an object of the present invention to provide an image processing method and apparatus that enhance a difference between pixels relating to a substantial structure in an image and other pixels, a medium recorded with a program for causing a computer to implement such an image processing function, and an imaging apparatus comprising such an image processing apparatus.  
           [0008]    (1) The present invention, in one aspect for solving the aforementioned problems, is an image processing method characterized in: with each pixel constituting an image defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; and maintaining the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest.  
           [0009]    (2) The present invention, in another aspect for solving the aforementioned problems, is an image processing apparatus characterized in comprising: variance calculating means for, with each pixel constituting an image defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; and pixel value adjusting means for maintaining the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest.  
           [0010]    (3) The present invention, in still another aspect for solving the aforementioned problems, is a recording medium characterized in being recorded in a computer-readable manner with a program for causing a computer to implement the functions of: with each pixel constituting an image defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; and maintaining the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest.  
           [0011]    (4) The present invention, in still another aspect for solving the aforementioned problems, is an imaging apparatus for producing an image based on signals collected from an object, characterized in comprising: variance calculating means for, with each pixel constituting an image defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; and pixel value adjusting means for maintaining the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest.  
           [0012]    According to the invention in the aspects as described in (1)-(4) above, with each pixel constituting an image defined as a pixel of interest, a variance of pixel values is determined in a local region to which the pixel of interest belongs, and the pixel value of the pixel of interest is maintained when the determined variance is significantly larger than a variance of noise, otherwise the pixel value of the pixel of interest is suppressed; and therefore a difference between pixels relating to a substantial structure in an image and other pixels can be enhanced.  
           [0013]    (5) The present invention, in still another aspect for solving the aforementioned problems, is an image processing method characterized in: with each pixel constituting an image defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; and enhancing the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest.  
           [0014]    (6) The present invention, in still another aspect for solving the aforementioned problems, is an image processing apparatus characterized in comprising: variance calculating means for, with each pixel constituting an image defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; and pixel value adjusting means for enhancing the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest.  
           [0015]    (7) The present invention, in still another aspect for solving the aforementioned problems, is a recording medium characterized in being recorded in a computer-readable manner with a program for causing a computer to implement the functions of: with each pixel constituting an image defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; and enhancing the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest.  
           [0016]    (8) The present invention, in still another aspect for solving the aforementioned problems, is an imaging apparatus for producing an image based on signals collected from an object, characterized in comprising: variance calculating means for, with each pixel constituting an image defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; and pixel value adjusting means for enhancing the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest.  
           [0017]    According to the invention in the aspects as described in (5)-(8) above, with each pixel constituting an image defined as a pixel of interest, a variance of pixel values is determined in a local region to which the pixel of interest belongs, and the pixel value of the pixel of interest is enhanced when the determined variance is significantly larger than a variance of noise, otherwise the pixel value of the pixel of interest is maintained; and therefore a difference between pixels relating to a substantial structure in an image and other pixels can be enhanced.  
           [0018]    Moreover, in the aspects as described in (1)-(8) above, the image may be a blood flow image to thereby enhance a difference between pixels relating to a blood flow image and other pixels.  
           [0019]    Furthermore, according to the invention in the aspects as described in (4) and (8) above, the signals may be magnetic resonance signals to thereby implement the invention for a magnetic resonance image.  
           [0020]    (9) The present invention, in still another aspect for solving the aforementioned problems, is an image processing method characterized in: with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; performing pixel value adjustment involving maintaining the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest; and performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0021]    (10) The present invention, in still another aspect for solving the aforementioned problems, is an image processing apparatus characterized in comprising: variance calculating means for, with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; pixel value adjusting means for maintaining the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest; and maximum intensity projecting means for performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0022]    (11) The present invention, in still another aspect for solving the aforementioned problems, is a recording medium characterized in being recorded in a computer-readable manner with a program for causing a computer to implement the functions of: with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; performing pixel value adjustment involving maintaining the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest; and performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0023]    (12) The present invention, in still another aspect for solving the aforementioned problems, is an imaging apparatus for producing an image based on signals collected from an object, characterized in comprising: variance calculating means for, with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; pixel value adjusting means for maintaining the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest; and maximum intensity projecting means for performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0024]    According to the invention in the aspects as described in (9)-(12) above, with each pixel constituting multi-slice images defined as a pixel of interest, a variance of pixel values is determined in a local region to which the pixel of interest belongs, and the pixel value of the pixel of interest is maintained when the determined variance is significantly larger than a variance of noise, otherwise the pixel value of the pixel of interest is suppressed; and therefore a difference between pixels relating to a substantial structure in an image and other pixels can be enhanced. In addition, since the multi-slice images subjected to such difference enhancement are maximum-intensity-projected, a projection image of pixels that have faint signal intensity and relate to a substantial structure in an image can be obtained.  
           [0025]    (13) The present invention, in still another aspect for solving the aforementioned problems, is an image processing method characterized in: with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; performing pixel value adjustment involving enhancing the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest; and performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0026]    (14) The present invention, in still another aspect for solving the aforementioned problems, is an image processing apparatus characterized in comprising: variance calculating means for, with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; pixel value adjusting means for enhancing the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest; and maximum intensity projecting means for performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0027]    (15) The present invention, in still another aspect for solving the aforementioned problems, is a recording medium characterized in being recorded in a computer-readable manner with a program for causing a computer to implement the functions of: with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; performing pixel value adjustment involving enhancing the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest; and performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0028]    (16) The present invention, in still another aspect for solving the aforementioned problems, is an imaging apparatus for producing an image based on signals collected from an object, characterized in comprising: variance calculating means for, with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; pixel value adjusting means for enhancing the pixel value of said pixel of interest when said determined variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest; and maximum intensity projecting means for performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0029]    According to the invention in the aspects as described in (13)-(16) above, with each pixel constituting multi-slice images defined as a pixel of interest, a variance of pixel values is determined in a local region to which the pixel of interest belongs, and the pixel value of the pixel of interest is enhanced when the determined variance is significantly larger than a variance of noise, otherwise the pixel value of the pixel of interest is maintained; and therefore a difference between pixels relating to a substantial structure in an image and other pixels can be enhanced. In addition, since the multi-slice images subjected to such difference enhancement are maximum-intensity-projected, a projection image of pixels that have faint signal intensity and relate to a substantial structure in an image can be obtained.  
           [0030]    Moreover, according to the invention in the aspects as described in (9)-(16) above, the image may be a blood flow image to thereby enhance a difference between pixels relating to a blood flow image and other pixels; and by maximum-intensity-projecting the multi-slice images subjected to such difference enhancement, a projection image of faint blood flow can be obtained.  
           [0031]    Furthermore, according to the invention in the aspects as described in (12) and (16) above, the signals may be magnetic resonance signals to thereby implement the invention for a magnetic resonance image.  
           [0032]    (17) The present invention, in still another aspect for solving the aforementioned problems, is an image processing method characterized in: with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; adding to said determined variance a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs; performing pixel value adjustment involving maintaining the pixel value of said pixel of interest when said added variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest; and performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0033]    (18) The present invention, in still another aspect for solving the aforementioned problems, is an image processing apparatus characterized in comprising: variance calculating means for, with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; adding means for adding to said determined variance a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs; pixel value adjusting means for maintaining the pixel value of said pixel of interest when said added variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest; and maximum intensity projecting means for performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0034]    (19) The present invention, in still another aspect for solving the aforementioned problems, is a recording medium characterized in being recorded in a computer-readable manner with a program for causing a computer to implement the functions of: with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; adding to said determined variance a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs; performing pixel value adjustment involving maintaining the pixel value of said pixel of interest when said added variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest; and performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0035]    (20) The present invention, in still another aspect for solving the aforementioned problems, is an imaging apparatus for producing an image based on signals collected from an object, characterized in comprising: variance calculating means for, with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; adding means for adding to said determined variance a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs; pixel value adjusting means for maintaining the pixel value of said pixel of interest when said added variance is significantly larger than a variance of noise, otherwise suppressing the pixel value of said pixel of interest; and maximum intensity projecting means for performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0036]    According to the invention in the aspects as described in (17)-(20) above, with each pixel constituting multi-slice images defined as a pixel of interest, a variance of pixel values is determined in a local region to which the pixel of interest belongs, a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs is added to the determined variance, and the pixel value of the pixel of interest is maintained when the added value is significantly larger than a variance of noise, otherwise the pixel value of the pixel of interest is suppressed; and therefore a difference between pixels relating to a substantial structure in an image and other pixels can be further enhanced. In addition, since the multi-slice images subjected to such difference enhancement are maximum-intensity-projected, a better projection image of pixels that have faint signal intensity and relate to a substantial structure in an image can be obtained.  
           [0037]    (21) The present invention, in still another aspect for solving the aforementioned problems, is an image processing method characterized in: with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; adding to said determined variance a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs; performing pixel value adjustment involving enhancing the pixel value of said pixel of interest when said added variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest; and performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0038]    (22) The present invention, in still another aspect for solving the aforementioned problems, is an image processing apparatus characterized in comprising: variance calculating means for, with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; adding means for adding to said determined variance a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs; pixel value adjusting means for enhancing the pixel value of said pixel of interest when said added variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest; and maximum intensity projecting means for performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0039]    (23) The present invention, in still another aspect for solving the aforementioned problems, is a recording medium characterized in being recorded in a computer-readable manner with a program for causing a computer to implement the functions of: with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; adding to said determined variance a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs; performing pixel value adjustment involving enhancing the pixel value of said pixel of interest when said added variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest; and performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0040]    (24) The present invention, in still another aspect for solving the aforementioned problems, is an imaging apparatus for producing an image based on signals collected from an object, characterized in comprising: variance calculating means for, with each pixel constituting multi-slice images defined as a pixel of interest, determining a variance of pixel values in a local region to which said pixel of interest belongs; adding means for adding to said determined variance a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs; pixel value adjusting means for enhancing the pixel value of said pixel of interest when said added variance is significantly larger than a variance of noise, otherwise maintaining the pixel value of said pixel of interest; and maximum intensity projecting means for performing maximum intensity projection on the multi-slice images subjected to said pixel value adjustment.  
           [0041]    According to the invention in the aspects as described in (21)-(24) above, with each pixel constituting multi-slice images defined as a pixel of interest, a variance of pixel values is determined in a local region to which the pixel of interest belongs, a variance of pixel values in a local region to which a corresponding pixel of interest in an image of a neighboring slice belongs is added to the determined variance, and the pixel value of the pixel of interest is enhanced when the added value is significantly larger than a variance of noise, otherwise the pixel value of the pixel of interest is maintained; and therefore a difference between pixels relating to a substantial structure in an image and other pixels can be further enhanced. In addition, since the multi-slice images subjected to such difference enhancement are maximum-intensity-projected, a better projection image of pixels that have faint signal intensity and relate to a substantial structure in an image can be obtained.  
           [0042]    Moreover, according to the invention in the aspects as described in (17)-(24) above, the image may be a blood flow image to thereby further enhance a difference between pixels relating to a blood flow image and other pixels; and by maximum-intensity-projecting the multi-slice images subjected to such difference enhancement, a better projection image of faint blood flow can be obtained.  
           [0043]    Furthermore, according to the invention in the aspects as described in (20) and (24) above, the signals may be magnetic resonance signals to thereby implement the invention for a magnetic resonance image.  
           [0044]    In the invention in the aspects as described in (1)-(24) above, it is preferred to determine a residual sum of squares of pixel values for each of a plurality of local regions defined over the entire image, determine a histogram of the residual sums of squares, and then determine the variance of noise based on a residual sum of squares that gives a peak of the histogram, in that the variance of noise can be obtained directly based on an image.  
           [0045]    Therefore, the present invention can provide an image processing method and apparatus that enhance a difference between pixels relating to a substantial structure in an image and other pixels, a medium recorded with a program for causing a computer to implement such an image processing function, and an imaging apparatus comprising such an image processing apparatus. 
       
    
    
       [0046]    Further objects and advantages of the present invention will be apparent from the following description of the preferred embodiments of the invention as illustrated in the accompanying drawings.  
       BRIEF DESCRIPTION OF THE DRAWINGS  
       [0047]    [0047]FIG. 1 is a block diagram of an apparatus in accordance with one embodiment of the present invention.  
         [0048]    [0048]FIG. 2 is a block diagram of an apparatus in accordance with one embodiment of the present invention.  
         [0049]    [0049]FIG. 3 is a flow chart of the operation of the apparatus shown in FIGS.  1  or  2 .  
         [0050]    [0050]FIG. 4 is a conceptual diagram of multi-slice images.  
         [0051]    [0051]FIG. 5 is a detailed flow chart of part of the flow chart shown in FIG. 3.  
         [0052]    [0052]FIG. 6 is a detailed flow chart of part of the flow chart shown in FIG. 5.  
         [0053]    [0053]FIG. 7 is a conceptual diagram of a histogram.  
         [0054]    [0054]FIG. 8 is a conceptual diagram of a histogram.  
         [0055]    [0055]FIG. 9 is a diagram illustrating a relationship between a pixel of interest and a local region.  
         [0056]    [0056]FIG. 10 is a flow chart of a procedure inserted as part of the flow chart shown in FIG. 5.  
         [0057]    [0057]FIG. 11 is an example of image profiles showing an effect of pixel value adjustment.  
         [0058]    [0058]FIG. 12 is an example of image profiles showing an effect of pixel value adjustment.  
         [0059]    [0059]FIG. 13 is a detailed flow chart of part of the flow chart shown in FIG. 3.  
         [0060]    [0060]FIG. 14 is an example of image profiles showing an effect of pixel value adjustment.  
         [0061]    [0061]FIG. 15 is an example of image profiles showing an effect of pixel value adjustment.  
         [0062]    [0062]FIG. 16 is a conceptual diagram of maximum intensity projection. 
     
    
     DETAILED DESCRIPTION OF THE INVENTION  
       [0063]    Embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that the present invention is not limited to these embodiments. FIG. 1 shows a block diagram of an imaging apparatus, or a magnetic resonance imaging (MRI) apparatus, which is an embodiment of the present invention. The configuration of the apparatus represents an embodiment of the apparatus in accordance with the present invention. The operation of the apparatus represents an embodiment of the method in accordance with the present invention.  
         [0064]    As shown in FIG. 1, the present apparatus has a magnet system  100 . The magnet system  100  has a main magnetic field coil section  102 , a gradient coil section  106  and an RF (radio frequency) coil section  108 . These coil sections have a generally cylindrical shape and are concentrically disposed. An object to be imaged  300  is rested on a cradle  500  and carried into and out of the generally cylindrical internal space (bore) of the magnet system  100  by carrier means, which is not shown.  
         [0065]    The main magnetic field coil section  102  generates a static magnetic field in the internal space of the magnet system  100 . The direction of the static magnetic field is generally in parallel with the direction of the body axis of the object  300 . That is, a “horizontal” magnetic field is generated. The main magnetic field coil section  102  is made using a superconductive coil, for example. It will be easily recognized that the main magnetic field coil section  102  is not limited to the superconductive coil, but may be made using a normal conductive coil or the like.  
         [0066]    The gradient coil section  106  generates gradient magnetic fields for imparting gradients to the static magnetic field strength. The gradient magnetic fields to be generated are the following three: a slice gradient magnetic field, a readout gradient magnetic field and a phase encoding gradient magnetic field. The gradient coil section  106  has three gradient coils, which are not shown, corresponding to these three gradient magnetic fields.  
         [0067]    The RF coil section  108  generates a high frequency magnetic field for exciting spins within the object  300  in the static magnetic field space. The generation of the high frequency magnetic field will be sometimes referred to as transmission of an RF excitation signal hereinbelow. The RF coil section  108  also receives electromagnetic waves, i.e., magnetic resonance signals, generated by the excited spins.  
         [0068]    The RF coil section  108  has transmitting and receiving coils, which are not shown. For the transmitting and receiving coils, the same coil or separate dedicated coils may be used.  
         [0069]    The gradient coil section  106  is connected with a gradient driving section  130 . The gradient driving section  130  supplies driving signals to the gradient coil section  106  to generate the gradient magnetic fields. The gradient driving section  130  has three driving circuits, which are not shown, corresponding to the three gradient coils in the gradient coil section  106 .  
         [0070]    The RF coil section  108  is connected with an RF driving section  140 . The RF driving section  140  supplies driving signals to the RF coil section  108  to transmit the RF excitation signal, thereby exciting the spins within the object  300 .  
         [0071]    The RF coil section  108  is connected with a data collecting section  150 . The data collecting section  150  gathers receive signals received by the RF coil section  108 , and collects the signals as view data.  
         [0072]    The gradient driving section  130 , RF driving section  140  and data collecting section  150  are connected with a control section  160 . The control section  160  controls the gradient driving section  130 , RF driving section  140  and data collecting section  150  to carry out imaging.  
         [0073]    The output of the data collecting section  150  is connected to a data processing section  170 . The data processing section  170  is, for example, constituted using a computer. The data processing section  170  has a memory, which is not shown. The memory stores programs for the data processing section  170  and several kinds of data. The function of the present apparatus is implemented by the data processing section  170  executing a program stored in the memory.  
         [0074]    The data processing section  170  stores the view data gathered from the data collecting section  150  into the memory. A data space is formed in the memory. The data space constitutes a two-dimensional Fourier space. The two-dimensional Fourier space is sometimes referred to as a k-space. The data processing section  170  performs a two-dimensional inverse Fourier transformation on the data in the two-dimensional Fourier space to produce (reconstruct) an image of the object  300 .  
         [0075]    The image reconstructed by the two-dimensional inverse Fourier transformation has pixel values of a complex number. The absolute value of the complex number is used to construct an absolute-value image. The real part of the complex number can be used to construct a real-part image. The imaginary part of the complex number can be used to construct an imaginary-part image. Both the real part and the imaginary part can be positive and negative values. Such an image is sometimes referred to as a positive-negative image.  
         [0076]    The data processing section  170  has the function of performing image processing for determining the variance of pixel values with respect to a reconstructed image. The data processing section  170  also has the function of performing image processing for determining the variance of noise with respect to the reconstructed image. The data processing section  170  further has the function of performing image processing for adjusting the pixel values with respect to the reconstructed image. The data processing section  170  furthermore has the function of performing image processing for executing maximum intensity projection (MIP) with respect to the image subjected to the pixel value adjustment. Such image processing functions of the data processing section  170  will be described later.  
         [0077]    The data processing section  170  is an embodiment of the image processing apparatus of the present invention. The configuration of the apparatus represents an embodiment of the apparatus in accordance with the present invention. The operation of the apparatus represents an embodiment of the method in accordance with the present invention.  
         [0078]    The data processing section  170  is connected to the control section  160 . The data processing section  170  is above the control section  160  and controls it. The data processing section  170  is connected with a display section  180  and an operating section  190 . The display section  180  comprises a graphic display, etc. The operating section  190  comprises a keyboard, etc., provided with a pointing device.  
         [0079]    The display section  180  displays the reconstructed image and several kinds of information output from the data processing section  170 . The operating section  190  is operated by a human operator, and the section  190  inputs several commands, information and so forth to the data processing section  170 . The operator interactively operates the present apparatus via the display section  180  and operating section  190 .  
         [0080]    [0080]FIG. 2 is a block diagram of an MRI apparatus of another type, which is one embodiment of the present invention. The configuration of the apparatus represents an embodiment of the apparatus in accordance with the present invention.  
         [0081]    The apparatus shown in FIG. 2 has a magnet system  100 ′ of a type different from that in the apparatus shown in FIG. 1. Since the apparatus has a configuration similar to that of the apparatus shown in FIG. 1 except for the magnet system  100 ′, similar portions are designated by similar reference numerals and the explanation thereof will be omitted.  
         [0082]    The magnet system  100 ′ has a main magnetic field magnet section  102 ′, a gradient coil section  106 ′ and an RF coil section  108 ′. The main magnetic field magnet section  102 ′ and the coil sections each consists of a pair of members facing each other across a space. These sections have a generally disk-like shape and are disposed to have a common center axis. The object  300  is rested on the cradle  500  and carried into and out of the internal space (bore) of the magnet system  100 ′ by carrier means, which is not shown.  
         [0083]    The main magnetic field magnet section  102 ′ generates a static magnetic field in the internal space of the magnet system  100 ′. The direction of the static magnetic field is generally orthogonal to the direction of the body axis of the object  300 . That is, a “vertical” magnetic field is generated. The main magnetic field magnet section  102 ′ is made using a permanent magnet, for example. It will be easily recognized that the main magnetic field magnet section  102 ′ is not limited to a permanent magnet, but may be made using a super or normal conductive electromagnet or the like.  
         [0084]    The gradient coil section  106 ′ generates gradient magnetic fields for imparting gradients to the static magnetic field strength. The gradient magnetic fields to be generated are the following three: a slice gradient magnetic field, a readout gradient magnetic field and a phase encoding gradient magnetic field. The gradient coil section  106 ′ has three gradient coils, which are not shown, corresponding to these three gradient magnetic fields.  
         [0085]    The RF coil section  108 ′ transmits an RF excitation signal for exciting spins within the object  300  in the static magnetic field space. The RF coil section  108 ′ also receives magnetic resonance signals generated by the excited spins. The RF coil section  108 ′ has transmitting and receiving coils, which are not shown. For the transmitting and receiving coils, the same coil or separate dedicated coils may be used.  
         [0086]    [0086]FIG. 3 shows a flow chart of the operation of the present apparatus. Both the apparatuses shown in FIGS. 1 and 2 operate in the same way. As shown in FIG. 3, blood flow imaging is performed at Step  302 . For the blood flow imaging, a time-of-flight (TOF) technique, phase contrast (PC) technique or the like is employed. Moreover, the imaging is performed in multi-slice. Thus, multi-slice blood flow tomographic images S 1 , S 2 , S 3 , . . . , Sm are captured with respect to a three-dimensional region of the object  300 , as conceptually shown in FIG. 4.  
         [0087]    Next, at Step  304 , pixel value adjustment is performed on the blood flow tomographic images S 1 , S 2 , S 3 , . . . , Sm. The pixel value adjustment is implemented by the data processing function of the data processing section  170 . The blood flow tomographic image will be referred to simply as an image hereinbelow.  
         [0088]    [0088]FIG. 5 shows a detailed flow chart of the pixel value adjustment. As shown, slice selection is performed at Step  502 . Thus, one of the images S 1 , S 2 , S 3 , . . . , Sm, for example, the image S 1 , is selected.  
         [0089]    Next, at Step  504 , calculation of the variance of noise is performed. The data processing section  170  that calculates the variance of noise at Step  504  is an embodiment of the noise variance calculating means of the present invention. FIG. 6 shows a detailed flow chart of the noise variance calculation. As shown, a local region is defined in an image at Step  602 . The local region is a region to which a pixel value for use in a calculation at the next step belongs. A local region in a center of an image, for example, is defined as the first region.  
         [0090]    As the local region, an N×N pixel matrix is employed. N is 9, for example. It should be noted that the matrix size is not limited to this value but may be any appropriate one. Moreover, the pixel matrix is not limited to a square matrix but may be any appropriate region centered on a pixel. The local region will sometimes be referred to simply as a region hereinbelow.  
         [0091]    Next, at Step  604 , a residual sum of squares S of pixel values that belong to the region is determined. Specifically,  
               S   =       ∑   i   k            (       P   i     -       P   _     i       )     2         ,           (   1   )                               
 
         [0092]    wherein:  
         [0093]    P i  is a pixel value, and {overscore (P)} i  is an average value of the pixel values in the N×N region centered on P i . Moreover, k is, for example, 81.  
         [0094]    Next, at Step  606 , a decision is made as to whether the above processes are finished for all the local regions, and if not, the local region is shifted at Step  608 . Thus, an adjacent N×N region, for example, is selected as a new local region.  
         [0095]    The process of Step  604  is performed on the new local region to determine the residual sum of squares of pixel values. Thereafter, a residual sum of squares of pixel values is determined for every local region in the image in a similar manner.  
         [0096]    The residual sums of squares thus obtained have a χ 2  distribution, and the average value thereof is κ·σ 2 . When k is large, the χ 2  distribution approximates to a Gaussian distribution, and its peak position lies approximately at κ·σ 2 .  
         [0097]    Next, at Step  610 , a histogram of the residual sums of squares S is generated.  
         [0098]    [0098]FIG. 7 shows the concept of the histogram of the residual sums of squares S when the image is an absolute-value image. As shown, the histogram consists of three distribution curves a, b and c.  
         [0099]    The distribution curve a is a Gaussian distribution curve, resulting from noise in the uniform structure portion. The distribution curve b is a Rayleigh distribution curve, resulting from noise in a portion of an FOV (field of view) that does not contain the object  300 , i.e., noise in a background. Because the image is an absolute-value image, the distribution curve resulting from noise in the background does not conform to the Gaussian distribution but to the Rayleigh distribution. The distribution curve c results from the fine structure of the object, and exhibits an indeterminate distribution, unlike the two other curves.  
         [0100]    At Step  612 , peak position detection is performed for such a histogram. Thus, a peak position s 1  is detected for the Gaussian distribution curve a, and a peak position s 2  is detected for the Rayleigh distribution curve b.  
         [0101]    Since the histogram has discrete values in practice, fitting to a function is preferably performed at Step  612  prior to the peak detection, in that the peak positions can be detected with a good accuracy. The functions employed in the fitting are, for example, a Gaussian distribution function and a Rayleigh distribution function, respectively. However, the functions are not limited thereto but may be any other appropriate one.  
         [0102]    Next, at Step  614 , the variance of noise is calculated. The calculation of the variance of noise is performed based on the peak position s 1  or s 2 .  
         [0103]    Since s 1 , s 2  and σ have respective relationships: 
           S   1     32  κ·σ   2 ,  (2) 
         [0104]    and  
                 S   2     =       (     2   -     π   2       )          k   ·     σ   2           ,           (   3   )                               
 
         [0105]    the value of σ is determined from these relationships. The value of σ is the same whether it is determined from Eq. (2) or from Eq. (3). The determined value of σ is stored in the memory as the variance of noise Vn.  
         [0106]    Under some conditions of the distribution curve c, the peak position s 1  of the Gaussian distribution curve a may not be accurately detected. In this case, the value of σ is determined based on the peak position s 2  of the Rayleigh distribution curve b. Moreover, with respect to an image having a larger proportion of the background portion area, the Rayleigh distribution curve b is more suitable for determining the variance of noise with a good accuracy.  
         [0107]    While the preceding description is made for a case of an absolute-value image, when the image to be processed is a positive-negative image, i.e., a real-part image or an imaginary-part image, noise in the background portion has positive and negative values centered on zero.  
         [0108]    Accordingly, the histogram generated at Step  610  becomes one as exemplarily shown in FIG. 8, and it no longer has the Rayleigh distribution. In this case, the variance of noise is determined based on the peak position s 1  of the Gaussian distribution curve a at Step  614 .  
         [0109]    A value of the variance of noise can thus be obtained directly based on an image that is actually captured. If the variance of noise is previously known, that variance may be used and the calculation may be omitted.  
         [0110]    After the variance of noise Vn is thus determined, a pixel of interest is defined in the image at Step  506  in the flow chart of FIG. 5. The first pixel of interest is, for example, a pixel in the center of the image.  
         [0111]    Next, at Step  508 , the variance of pixel values Vi in a local region that contains the pixel of interest is calculated. The local region that contains the pixel of interest is, for example, a 5×5 matrix centered on the pixel of interest i, as shown in FIG. 9. It should be noted that the matrix size is not limited to this value but may be any appropriate one. Moreover, the pixel matrix is not limited to a square matrix but may be any appropriate region centered on a pixel. The local region will sometimes be referred to simply as a region hereinbelow. The data processing section  170  that calculates the variance of pixel values Vi at Step  508  is an embodiment of the variance calculating means of the present invention.  
         [0112]    The following equation is employed for the calculation of the variance of pixel values Vi:  
                 V   i     =         ∑   i   k            (       P   i     -       P   _     i       )     2       k       ,           (   4   )                               
 
         [0113]    wherein k=25.  
         [0114]    Next, at Step  510 , a decision is made as to whether the variance of pixel values Vi is significantly larger than the variance of noise Vn. The decision is made using the following formula:  
                   V   i       V   n       &gt;   γ     ,           (   5   )                               
 
         [0115]    wherein:  
         [0116]    γ: a threshold value.  
         [0117]    For the value of the threshold γ, an appropriate value greater than one is employed.  
         [0118]    If the variance of pixel values in the local region that contains the pixel of interest is not significantly greater than the variance of noise, the image in the local region probably has no prominent structure, and the variance of pixel values probably originates from noise.  
         [0119]    Hence, in this case, the pixel value of the pixel of interest is suppressed at Step  512 . The suppression of the pixel value is achieved by, for example, multiplying the pixel value by a coefficient α. The value of the coefficient α is a positive number less than one, for example, 0.8. Thus, the pixel value of the pixel of interest is reduced by, for example, 0.8 times the original value. However, the value of the coefficient a is not limited to 0.8 but may be any appropriate one. Moreover, the suppression of the pixel value may be achieved by, for example, subtracting a certain predefined value from the pixel value. It should be noted that the constant value does not exceed the minimum of the pixel values.  
         [0120]    If the variance of pixel values Vi in the local region that contains the pixel of interest is significantly greater than the variance of noise Vn, the image in the local region probably has a specific structure, such as an edge, and the variance of pixel values probably originates from the structure of the image. In this case, no special operation is applied to the pixel value. Thus, the pixel value of the pixel of interest maintains its original value. The data processing section  170  that performs such pixel value adjustment is an embodiment of the pixel value adjusting means of the present invention.  
         [0121]    Next, at Step  514 , a decision is made as to whether the above processes are finished for all the pixels of interest, and if not, the pixel of interest is shifted to, for example, the adjacent one at Step  516 , and the processes from Step  508  are performed. Thereafter, the same processes are repeated to adjust the pixel value for every pixel in the image S 1 .  
         [0122]    Then, at Step  518 , a decision is made as to whether the above processes are finished for all the slices, and if not, the slice is shifted at Step  520 , and the same processes are performed on the image of that slice. Thereafter, the same processes are repeated to perform the pixel value adjustment on the pixels in all the images S 1 -Sm.  
         [0123]    Between Steps  508  and  510 , steps as shown in the flow chart of FIG. 10 may be added. Specifically, the variance of pixel values Vi′ is calculated for a local region that contains a corresponding pixel of interest in a neighboring slice at Step  702 .  
         [0124]    The term ‘neighboring slice’ implies one or more slices adjoining the slice for which the variance of pixel values Vi has been determined at Step  508 . For such slices, a slice adjoining the front or the rear, or slices adjoining the front and rear may be employed, for example.  
         [0125]    At Step  704 , the variance(s) of pixel values Vi′ is added to Vi, and the added value is defined as a variance of pixel values Vi for use in the decision at next Step  510 . An appropriate weight may be applied to Vi′ in the addition. The data processing section  170  that calculates the variances of pixel values at Step  702  is an embodiment of the pixel value variance calculating means of the present invention. The data processing section  170  that adds the variances of pixel values at Step  704  is an embodiment of the adding means of the present invention.  
         [0126]    Thus, a structure across a plurality of slices is reflected in the variance of pixel values Vi obtained by the above processing. Therefore, for example, if a blood flow image exists in a direction passing through slices, which image should appear as one point on one image, a variance of pixel values exactly reflecting such a structure can be obtained, and more exact pixel value adjustment can be achieved based on the variance.  
         [0127]    [0127]FIG. 11 shows an effect of such pixel value adjustment as a change in a pixel value profile. The symbol B in FIG. 11 denotes a profile before the pixel value adjustment, and there exist a distinct blood flow image b 1  and a faint blood flow image b 2  over background noise.  
         [0128]    As a result of the above-described pixel value adjustment, such a profile has pixel values of the background noise suppressed by, for example, 0.8 times while maintaining pixel values of the blood flow images b 1  and b 2 , resulting in a profile as shown at A in FIG. 11. In the profile A, the blood flow image b 2  which was faint in the original image exhibits an enlarged difference from the background noise and becomes distinct, not to mention the blood flow image b 1 . Thus, elicitability of the blood flow image b 2  that was faint in the original image can be enhanced.  
         [0129]    [0129]FIG. 12 shows another effect of the pixel value adjustment. The symbols P and Q in FIG. 12 denote profiles of two images of different slices, and the background noise level of the profile Q is larger than the signal intensity of a distinct blood flow image b 1  in the profile P.  
         [0130]    By the aforementioned pixel value adjustment, such profiles have pixel values of the background noise suppressed by, for example, 0.8 times and therefore a profile can be obtained that has the noise level reduced relative to the signal intensity of the blood flow images b 1  and b 2 , as shown at Q′ in FIG. 12. Thus, a difference of the blood flow images b 1  and b 2  from the noise level of the image of the slice Q also becomes distinct, and both images can be elicited.  
         [0131]    [0131]FIG. 13 shows a flow chart of another procedure of the pixel value adjustment. In FIG. 13, similar steps to those shown in FIG. 5 are designated by similar reference numerals and the explanation thereof will be omitted. The difference between the procedures shown in FIGS. 5 and 13 is in pixel value processing after the decision at Step  510 .  
         [0132]    Specifically, if the variance of pixel values is significantly larger than the variance of noise in a local region that contains a pixel of interest, the pixel value of the pixel of interest is enhanced at Step  512 ′. The enhancement of the pixel value is achieved by, for example, multiplying the pixel value by a coefficient β. The value of the coefficient β is a positive number greater than one, for example, 1.2. Thus, the pixel value of the pixel of interest is enlarged by, for example, 1.2 times the original value. It should be noted that the value of the coefficient β is not limited to 1.2 but may be any appropriate one. Moreover, instead of multiplying by a coefficient, the enhancement of the pixel value may be achieved by, for example, adding a certain predefined value to the pixel value.  
         [0133]    If the variance of pixel values Vi in the local region that contains the pixel of interest is not significantly greater than the variance of noise Vn, no special operation is applied to the pixel value. Thus, the pixel value of the pixel of interest maintains its original value. The data processing section  170  that performs such pixel value adjustment is an embodiment of the pixel value adjusting means of the present invention.  
         [0134]    [0134]FIG. 14 shows an effect of such pixel value adjustment by a change in a profile of pixel values. As shown, blood flow images b 1  and b 2  in a profile before the pixel value adjustment will have enlarged pixel values as a result of the aforementioned pixel value adjustment, as shown by blood flow images b 1 ′ and b 2 ′. Thus, the difference from the background noise is enlarged and elicitability is enhanced.  
         [0135]    [0135]FIG. 15 shows another effect of the pixel value adjustment. The symbols P and Q in FIG. 15 denote profiles of two images of different slices. Even when the background noise level of the profile Q is larger than the signal intensity of a distinct blood flow image b 1  in the profile P, the pixel values of the blood flow images b 1  and b 2  in the profile P is enlarged by, for example, 1.2 times by the aforementioned pixel value adjustment, resulting in blood flow images b 1 ′ and b 2 ′. Thus, the blood flow images b 1 ′ and b 2 ′ can also be elicited relative to the noise level of the image of the slice Q.  
         [0136]    For the multi-slice images after the pixel adjustment as described above, maximum intensity projection (MIP) is performed at Step  306  in the flow chart of FIG. 3. The data processing section  170  that performs the maximum intensity projection at Step  306  is an embodiment of the maximum intensity projecting means of the present invention.  
         [0137]    A program for a computer to implement the functions as described above is recorded on a recording medium in a computer-readable manner. For the recording medium, for example, any one of a magnetic recording medium, an optical recording medium, a magneto-optical recording medium and any other appropriate type of recording medium is employed. The recording medium may be a semiconductor storage medium. A storage medium is synonymous with a recording medium in the present specification.  
         [0138]    [0138]FIG. 16 shows a conceptual diagram of the maximum intensity projection. As shown, the maximum of pixel values is extracted along a line of sight E passing through the multi-slice images S 1 -Sm, and the extracted value is used as a pixel value for a projection image R. A number of lines of sight that is equal to the number of pixels in the projection image R are employed as the line of sight E.  
         [0139]    According to the pixel value adjustment as described above, since a difference between a blood flow image and noise is enhanced for every image S 1 -Sm, even a faint blood flow image can be distinctly rendered without being obscured by noise. Therefore, an MIP image having a distinct blood flow image can be obtained even if the blood flow image is faint. Such an MIP image is displayed on the display section  180  at Step  308 .  
         [0140]    The preceding description has been made on an example in which the image processing is performed by a data processing section in a magnetic resonance imaging apparatus; however, it will be easily recognized that the image processing may be performed by a data processing apparatus separate from the magnetic resonance imaging apparatus, such as an EWS (engineering workstation) or PC (personal computer).  
         [0141]    Moreover, although the imaging apparatus has been described as being an MRI apparatus, the imaging apparatus is not limited thereto but may be any other type of imaging apparatus, such as an X-ray CT (computed tomography) apparatus, an X-ray imaging apparatus, PET (positron emission tomography) or a γ-camera.  
         [0142]    Furthermore, while the description has been made with reference to an example of processing a medical image, the object to be processed is not limited to a medical image, but image processing on a variety of images, such as a digital image captured by an optical instrument, can be performed.  
         [0143]    While the present invention has been described with reference to preferred embodiments hereinabove, various changes or substitutions may be made on these embodiments by those ordinarily skilled in the art pertinent to the present invention without departing from the scope of the present invention. Therefore, the technical scope of the present invention encompasses not only those embodiments described above but all the embodiments that fall within the scope of the appended claims.

Technology Category: 3