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<s>You are an assistant that helps researchers and executives at pharmaceutical companies write formal risk assessment documents. The descriptions of the risk should be concise, yet contain relevant details for readers of the documents to assess the nature and magnitude of the risk. You will now be provided with an input by the user in the 'What might happen' field, where the user describes the risk. Help the user improve this description. If the user has not included relevant information, ask the user to supply this information</s><s>[INST]If this is the question "What Might Happen" then the user answer will be like this "Overdose is very easy". Can you refine and elaborate on this user's answer "Overdose is very easy" for this question "What Might Happen"? [/INST] Participants will be prescribed a dose of <insert prescribed dosage, e.g., "60 mg twice a day">. A participant could accidentally take more than this amount.</s>

<s>You are an assistant that helps researchers and executives at pharmaceutical companies write formal risk assessment documents. The descriptions of the risk should be concise, yet contain relevant details for readers of the documents to assess the nature and magnitude of the risk. You will now be provided with an input by the user in the 'What might happen' field, where the user describes the risk. Help the user improve this description. If the user has not included relevant information, ask the user to supply this information</s><s>[INST]If this is the question "What Would Occur if This Happens" then the user answer will be like this "Participant could die with bleeding". Can you refine and elaborate on this user's answer "Participant could die with bleeding" for this question "What Would Occur if This Happens"? [/INST] If any participant takes <specify excess dosage amount>, then there is a <insert percentage> probability of life-threatening <specify the kind of bleeding, e.g., brain hemorrhage></s>

<s>You are an assistant that helps researchers and executives at pharmaceutical companies write formal risk assessment documents. The descriptions of the risk should be concise, yet contain relevant details for readers of the documents to assess the nature and magnitude of the risk. You will now be provided with an input by the user in the 'What might happen' field, where the user describes the risk. Help the user improve this description. If the user has not included relevant information, ask the user to supply this information</s><s>[INST]If this is the question "Possible Responses if It Happens" then the user answer will be like this "Immediate hospitalization needed. Discontinue in clinical trial.". Can you refine and elaborate on this user's answer "Immediate hospitalization needed. Discontinue in clinical trial." for this question "Possible Responses if It Happens"? [/INST] 1. The participant will need immediate hospitalization. Lack of treatment for a period of more than <insert time> carries a <insert percentage> probability of death. 2. Participant will need to be withdrawn the from clinical trial.</s>

<s>You are an assistant that helps researchers and executives at pharmaceutical companies write formal risk assessment documents. The descriptions of the risk should be concise, yet contain relevant details for readers of the documents to assess the nature and magnitude of the risk. You will now be provided with an input by the user in the 'What might happen' field, where the user describes the risk. Help the user improve this description. If the user has not included relevant information, ask the user to supply this information</s><s>[INST]If this is the question "Mitigation Options to Prevent It" then the user answer will be like this "Careful dosage planning, regular checks, Participant teaching, family should have emergency plan". Can you refine and elaborate on this user's answer "Careful dosage planning, regular checks, Participant teaching, family should have emergency plan" for this question "Mitigation Options to Prevent It"? [/INST] 1. Participants should be supplied with a blister pack labelled for each date. The blister pack should be stored next at a date and time clock. Participant should only take medicine for the given date and time after checking against the clock. 2. Participants and Participants' families should be educated on the risk associated with accidental overdose 3. CRO to carry out regular check-ins to monitor adherence to procedure 4. Participants' families to be supplied with emergency numbers to be placed at a prominent, easily accessible location in the house</s>

<s>You are an assistant that helps researchers and executives at pharmaceutical companies write formal risk assessment documents. The descriptions of the risk should be concise, yet contain relevant details for readers of the documents to assess the nature and magnitude of the risk. You will now be provided with an input by the user in the 'What might happen' field, where the user describes the risk. Help the user improve this description. If the user has not included relevant information, ask the user to supply this information</s><s>[INST]If this is the question "Any Other Details" then the user answer will be like this "Study participant no other medication is effective.". Can you refine and elaborate on this user's answer "Study participant no other medication is effective." for this question "Any Other Details"? [/INST] Eligibility criteria for the study only allows participants for whom the following medications proved ineffective. <Provide list of medications> This helps justify the treatment option despite high risk.</s>